# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Cytochrom_B_N_2 PF13631.1 ESL04761.1 - 8e-26 90.8 29.7 8e-26 90.8 20.6 3.3 3 1 0 4 4 4 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.12 ESL04761.1 - 2.7e-11 43.6 13.9 2.7e-11 43.6 9.7 4.4 2 1 1 3 3 3 1 Cytochrome b(C-terminal)/b6/petD Cytochrom_B_N PF00033.14 ESL04761.1 - 4.7e-05 22.8 35.3 4.7e-05 22.8 24.5 3.6 2 2 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB COX2 PF00116.15 ESL04764.1 - 2.4e-09 37.0 0.2 2.4e-09 37.0 0.1 1.9 2 0 0 2 2 2 1 Cytochrome C oxidase subunit II, periplasmic domain COX1 PF00115.15 ESL04766.1 - 3.6e-123 411.4 76.5 3.6e-123 411.4 53.0 1.8 1 1 1 2 2 2 1 Cytochrome C and Quinol oxidase polypeptide I Oxidored_q1 PF00361.15 ESL04767.1 - 4.4e-24 85.1 62.6 4.4e-24 85.1 43.4 3.5 1 1 3 4 4 4 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1 PF00361.15 ESL04768.1 - 7.9e-62 208.9 51.0 7.9e-62 208.9 35.4 5.7 1 1 3 5 5 5 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Ribosomal_L19e PF01280.15 ESL04769.1 - 9e-62 207.2 14.4 9e-62 207.2 10.0 2.2 1 1 1 2 2 2 1 Ribosomal protein L19e DUF2202 PF09968.4 ESL04769.1 - 0.038 13.6 0.9 0.059 13.0 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) BASP1 PF05466.7 ESL04769.1 - 6.3 6.5 51.3 9 6.0 35.5 1.2 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) Asp-B-Hydro_N PF05279.6 ESL04769.1 - 8.7 6.1 11.7 13 5.5 8.1 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Ribosomal_L7Ae PF01248.21 ESL04770.1 - 2.9e-17 61.9 0.1 3.8e-17 61.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family VirionAssem_T7 PF11653.3 ESL04770.1 - 0.05 14.3 0.6 0.076 13.7 0.4 1.4 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein DUF3443 PF11925.3 ESL04770.1 - 0.083 11.5 0.0 0.096 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3443) tRNA-synt_1g PF09334.6 ESL04771.1 - 5.2e-113 377.6 0.0 7e-113 377.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ESL04771.1 - 2.9e-20 71.8 0.3 1.6e-10 39.6 0.8 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 ESL04771.1 - 7.5e-07 28.5 0.0 0.014 14.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 ESL04771.1 - 0.045 12.5 0.0 0.16 10.7 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (R) DUF1641 PF07849.6 ESL04771.1 - 0.082 12.5 0.1 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) DUF3487 PF11990.3 ESL04773.1 - 0.3 10.4 1.2 0.36 10.2 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) DUF4638 PF15472.1 ESL04775.1 - 0.039 13.5 0.5 0.041 13.4 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) BLVR PF06375.6 ESL04775.1 - 0.064 13.0 2.7 0.076 12.8 1.9 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Mem_trans PF03547.13 ESL04775.1 - 0.11 10.7 0.0 0.11 10.7 0.0 1.0 1 0 0 1 1 1 0 Membrane transport protein NinE PF05322.6 ESL04775.1 - 2.6 7.8 7.1 1.2 8.9 0.1 2.3 1 1 1 2 2 2 0 NINE Protein Glucos_trans_II PF14264.1 ESL04778.1 - 0.017 14.1 5.8 0.019 13.9 4.0 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII Pex24p PF06398.6 ESL04778.1 - 0.94 8.2 3.8 1 8.0 2.7 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF4662 PF15578.1 ESL04780.1 - 0.95 8.9 5.9 1.1 8.8 4.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) DUF4407 PF14362.1 ESL04780.1 - 2.3 7.0 5.8 2.9 6.7 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CM_2 PF01817.16 ESL04783.1 - 0.69 10.0 3.5 0.99 9.5 2.4 1.2 1 0 0 1 1 1 0 Chorismate mutase type II Band_3_cyto PF07565.8 ESL04783.1 - 3.9 6.9 7.7 4.3 6.7 5.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NdhL PF10716.4 ESL04786.1 - 3.3 7.5 6.9 0.12 12.1 0.7 1.6 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit RRM_3 PF08777.6 ESL04790.1 - 0.055 13.3 2.7 0.067 13.0 1.9 1.1 1 0 0 1 1 1 0 RNA binding motif DUF4604 PF15377.1 ESL04790.1 - 1 9.5 10.9 1.1 9.4 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Filo_glycop PF01611.11 ESL04790.1 - 1 8.0 6.8 1.1 8.0 4.7 1.1 1 0 0 1 1 1 0 Filovirus glycoprotein DUF1418 PF07214.7 ESL04791.1 - 0.25 11.0 1.1 0.28 10.8 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) Mito_fiss_reg PF05308.6 ESL04797.1 - 0.0056 16.0 0.5 0.0056 16.0 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial fission regulator AA_permease_2 PF13520.1 ESL04799.1 - 0.024 13.1 2.0 0.028 12.9 0.1 1.6 1 1 1 2 2 2 0 Amino acid permease 7TM_GPCR_Srv PF10323.4 ESL04799.1 - 0.1 11.7 1.9 0.12 11.5 1.3 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF4131 PF13567.1 ESL04799.1 - 0.48 9.7 2.8 0.55 9.6 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) GCK PF07802.6 ESL04800.1 - 0.071 13.2 0.5 0.14 12.2 0.1 1.6 2 0 0 2 2 2 0 GCK domain TNFR_c6 PF00020.13 ESL04800.1 - 0.077 13.0 2.9 0.15 12.1 1.5 1.8 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region Tmemb_185A PF10269.4 ESL04802.1 - 0.23 11.0 4.8 0.23 11.0 3.3 1.0 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein Pox_P21 PF05313.7 ESL04802.1 - 0.58 9.3 2.9 0.62 9.2 2.0 1.0 1 0 0 1 1 1 0 Poxvirus P21 membrane protein Got1 PF04178.7 ESL04802.1 - 0.75 9.9 7.2 0.81 9.8 5.0 1.1 1 0 0 1 1 1 0 Got1/Sft2-like family DUF4131 PF13567.1 ESL04802.1 - 1.7 8.0 5.5 1.8 7.9 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PAP2 PF01569.16 ESL04804.1 - 0.0082 15.8 2.5 0.0091 15.6 1.7 1.1 1 0 0 1 1 1 1 PAP2 superfamily YwiC PF14256.1 ESL04806.1 - 0.031 14.3 0.3 0.034 14.2 0.2 1.0 1 0 0 1 1 1 0 YwiC-like protein GPI2 PF06432.6 ESL04806.1 - 0.19 11.0 4.3 0.21 10.8 3.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Peptidase_S49_N PF08496.5 ESL04807.1 - 0.91 9.2 3.8 1.1 9.0 2.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3043 PF11241.3 ESL04808.1 - 0.049 13.2 0.0 0.057 13.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF2244 PF10003.4 ESL04808.1 - 0.073 12.4 1.7 0.086 12.2 1.2 1.1 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) DUF1212 PF06738.7 ESL04808.1 - 0.11 11.9 1.9 0.12 11.8 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) CoA_binding_3 PF13727.1 ESL04808.1 - 0.16 11.7 1.2 0.19 11.5 0.8 1.1 1 0 0 1 1 1 0 CoA-binding domain DUF4131 PF13567.1 ESL04808.1 - 0.23 10.8 3.2 0.3 10.4 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) FtsX PF02687.16 ESL04810.1 - 2.8 7.7 6.0 3.7 7.3 4.2 1.1 1 0 0 1 1 1 0 FtsX-like permease family DUF3405 PF11885.3 ESL04811.1 - 0.24 9.5 2.4 0.29 9.3 1.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF3043 PF11241.3 ESL04811.1 - 5 6.6 7.5 6.5 6.3 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4220 PF13968.1 ESL04815.1 - 0.0053 15.9 0.6 0.0062 15.6 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4220) DRY_EERY PF09750.4 ESL04815.1 - 0.0085 16.1 2.8 0.012 15.6 1.9 1.2 1 0 0 1 1 1 1 Alternative splicing regulator DUF1764 PF08576.5 ESL04815.1 - 0.03 15.1 3.5 0.03 15.1 2.4 1.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Nucleo_P87 PF07267.6 ESL04815.1 - 0.31 9.6 3.1 0.36 9.4 2.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF3451 PF11933.3 ESL04815.1 - 1 9.1 8.2 1.2 8.9 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3451) DUF2781 PF10914.3 ESL04816.1 - 0.43 10.3 8.7 0.55 9.9 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) TraG_N PF07916.6 ESL04816.1 - 4.8 5.5 8.6 5 5.4 6.0 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region DUF2418 PF10332.4 ESL04816.1 - 5.2 7.4 6.0 6.1 7.2 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) DUF4557 PF15101.1 ESL04820.1 - 0.34 10.7 3.9 0.31 10.8 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF4131 PF13567.1 ESL04821.1 - 0.9 8.9 9.3 6.5 6.1 3.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SMAP PF15477.1 ESL04823.1 - 0.13 12.5 4.1 0.18 12.0 2.8 1.2 1 0 0 1 1 1 0 Small acidic protein family GAGA_bind PF06217.7 ESL04823.1 - 0.17 11.8 3.9 0.2 11.6 2.7 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family RSN1_TM PF13967.1 ESL04824.1 - 0.022 14.3 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Mucin PF01456.12 ESL04826.1 - 0.002 17.8 0.1 0.0023 17.7 0.1 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF1230 PF06799.6 ESL04827.1 - 0.19 11.5 0.3 0.22 11.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1230) NAP PF00956.13 ESL04828.1 - 0.025 13.6 1.1 0.031 13.3 0.8 1.0 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) Peptidase_M35 PF02102.10 ESL04828.1 - 0.057 12.0 0.1 0.07 11.7 0.1 1.0 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family DBC1 PF14443.1 ESL04828.1 - 0.13 11.8 0.1 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 DBC1 WBP-1 PF11669.3 ESL04828.1 - 2.2 8.3 6.5 0.36 10.9 0.9 2.0 1 1 1 2 2 2 0 WW domain-binding protein 1 Mito_fiss_reg PF05308.6 ESL04829.1 - 0.0055 16.1 0.6 0.0067 15.8 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator NBP1 PF08537.5 ESL04829.1 - 3.5 6.7 8.1 3.9 6.6 5.6 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 5TM-5TMR_LYT PF07694.7 ESL04830.1 - 0.0037 16.6 0.0 0.0043 16.4 0.0 1.1 1 0 0 1 1 1 1 5TMR of 5TMR-LYT DUF3328 PF11807.3 ESL04830.1 - 0.21 11.2 0.8 0.25 10.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Microvir_lysis PF04517.7 ESL04830.1 - 0.48 10.1 3.2 1.4 8.7 2.2 1.8 1 0 0 1 1 1 0 Microvirus lysis protein (E), C terminus DUF4118 PF13493.1 ESL04831.1 - 0.053 13.7 2.4 0.061 13.5 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) Cytochrom_B_N PF00033.14 ESL04832.1 - 0.11 11.7 1.2 0.12 11.6 0.8 1.1 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB DUF4280 PF14107.1 ESL04834.1 - 0.01 16.1 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4280) v110 PF01639.12 ESL04837.1 - 7 6.2 8.9 7.6 6.1 5.9 1.4 1 1 0 1 1 1 0 Viral family 110 SLBP_RNA_bind PF15247.1 ESL04838.1 - 0.4 10.4 4.3 0.53 10.0 3.0 1.3 1 1 0 1 1 1 0 Histone RNA hairpin-binding protein RNA-binding domain Dicty_REP PF05086.7 ESL04838.1 - 2.8 5.5 9.0 3 5.4 6.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4583 PF15190.1 ESL04839.1 - 0.087 12.4 1.1 0.11 12.1 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4583) DUF912 PF06024.7 ESL04839.1 - 0.36 10.8 1.5 0.49 10.4 1.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Tetraspannin PF00335.15 ESL04839.1 - 6.8 5.9 9.0 8.3 5.6 6.2 1.2 1 0 0 1 1 1 0 Tetraspanin family UPF0542 PF15086.1 ESL04841.1 - 0.74 9.5 0.0 0.74 9.5 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 DUF1364 PF07102.7 ESL04846.1 - 0.21 11.4 1.6 0.39 10.6 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1364) DUF1183 PF06682.7 ESL04849.1 - 4.4 6.8 8.5 5 6.6 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) BLVR PF06375.6 ESL04849.1 - 10 5.9 13.1 18 5.1 5.1 2.1 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) FAR1 PF03101.10 ESL04851.1 - 0.2 12.1 3.1 0.26 11.8 2.1 1.2 1 0 0 1 1 1 0 FAR1 DNA-binding domain DUF612 PF04747.7 ESL04854.1 - 0.017 14.0 1.1 0.018 13.9 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF612 DUF4131 PF13567.1 ESL04861.1 - 9.1 5.6 9.5 11 5.3 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3413 PF11893.3 ESL04862.1 - 0.051 12.4 0.7 0.052 12.4 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3413) FixQ PF05545.6 ESL04862.1 - 0.5 10.0 0.2 0.5 10.0 0.1 2.7 2 1 1 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ ETRAMP PF09716.5 ESL04863.1 - 0.14 12.1 0.2 0.16 11.9 0.1 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Transposase_28 PF04195.7 ESL04867.1 - 2.7 7.2 5.5 2.9 7.1 3.8 1.2 1 0 0 1 1 1 0 Putative gypsy type transposon DUF4227 PF14004.1 ESL04867.1 - 6.2 6.7 7.4 1.8 8.4 1.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) AF-4 PF05110.8 ESL04873.1 - 0.036 11.9 3.0 0.041 11.7 2.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TT_ORF1 PF02956.9 ESL04873.1 - 0.39 9.1 9.7 0.44 8.9 6.7 1.2 1 0 0 1 1 1 0 TT viral orf 1 Nucleocapsid-N PF11030.3 ESL04873.1 - 0.99 9.1 4.2 1.3 8.8 2.9 1.2 1 0 0 1 1 1 0 Nucleocapsid protein N Sigma70_ECF PF07638.6 ESL04873.1 - 2.2 7.8 6.1 3.2 7.3 4.3 1.3 1 0 0 1 1 1 0 ECF sigma factor Asp-B-Hydro_N PF05279.6 ESL04878.1 - 0.21 11.3 0.6 0.23 11.2 0.4 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DAP10 PF07213.6 ESL04883.1 - 2.5 7.9 6.4 2.4 7.9 3.7 1.5 1 1 1 2 2 2 0 DAP10 membrane protein YwiC PF14256.1 ESL04884.1 - 0.07 13.2 2.4 0.089 12.8 1.7 1.2 1 0 0 1 1 1 0 YwiC-like protein zf-DHHC PF01529.15 ESL04884.1 - 0.55 9.6 4.5 0.6 9.4 3.1 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase Tower PF09121.5 ESL04885.1 - 0.6 10.1 0.0 0.6 10.1 0.0 2.8 3 0 0 3 3 3 0 Tower Dpy19 PF10034.4 ESL04886.1 - 0.12 10.5 6.5 0.14 10.2 4.5 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF1673 PF07895.6 ESL04886.1 - 2.2 7.7 5.2 2.6 7.5 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Sulfate_transp PF00916.15 ESL04889.1 - 0.021 13.8 1.1 0.022 13.7 0.8 1.1 1 0 0 1 1 1 0 Sulfate transporter family DUF443 PF04276.7 ESL04896.1 - 0.19 11.1 2.6 0.26 10.6 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF443) TcpE PF12648.2 ESL04896.1 - 0.34 11.0 2.7 0.45 10.6 1.9 1.3 1 1 0 1 1 1 0 TcpE family DUF1700 PF08006.6 ESL04896.1 - 0.46 9.7 2.5 0.51 9.6 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Ndc1_Nup PF09531.5 ESL04896.1 - 3.6 5.9 6.6 3.8 5.8 4.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDO_I PF05995.7 ESL04901.1 - 0.037 13.1 0.3 0.046 12.8 0.2 1.0 1 0 0 1 1 1 0 Cysteine dioxygenase type I Peptidase_S49_N PF08496.5 ESL04901.1 - 0.047 13.4 0.5 0.053 13.3 0.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MRP-L46 PF11788.3 ESL04901.1 - 0.089 13.4 0.8 0.1 13.2 0.6 1.1 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 BLVR PF06375.6 ESL04901.1 - 0.11 12.3 3.7 0.13 12.0 2.6 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Vps4_C PF09336.5 ESL04905.1 - 1.1e-05 25.2 0.1 1.6e-05 24.7 0.1 1.3 1 1 0 1 1 1 1 Vps4 C terminal oligomerisation domain HTH_44 PF14641.1 ESL04905.1 - 0.037 14.0 0.0 0.037 14.0 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 Rrn6 PF10214.4 ESL04906.1 - 0.078 11.0 1.9 0.088 10.8 1.3 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor ETRAMP PF09716.5 ESL04907.1 - 0.049 13.5 0.1 0.049 13.5 0.0 2.0 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) OapA_N PF08525.6 ESL04911.1 - 0.1 12.4 0.6 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif SPC12 PF06645.8 ESL04917.1 - 7.4 6.4 6.2 16 5.4 3.6 1.8 1 1 1 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF1625 PF07787.7 ESL04919.1 - 0.24 10.6 1.5 0.26 10.4 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1625) DUF4131 PF13567.1 ESL04921.1 - 0.03 13.7 0.2 0.036 13.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Fig1 PF12351.3 ESL04921.1 - 0.076 12.8 0.1 0.095 12.5 0.0 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 FixQ PF05545.6 ESL04921.1 - 1.8 8.2 8.4 0.67 9.6 0.4 2.3 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ NapE PF06796.6 ESL04922.1 - 0.19 11.0 0.7 0.23 10.7 0.5 1.2 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Yip1 PF04893.12 ESL04922.1 - 7.3 6.0 7.1 27 4.1 0.9 1.9 1 1 1 2 2 2 0 Yip1 domain ABC2_membrane_3 PF12698.2 ESL04923.1 - 0.76 8.7 6.1 0.99 8.3 4.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein PknH_C PF14032.1 ESL04925.1 - 0.071 12.6 0.2 0.071 12.6 0.1 1.1 1 0 0 1 1 1 0 PknH-like extracellular domain ABC2_membrane_5 PF13346.1 ESL04926.1 - 0.046 13.0 3.7 0.062 12.5 2.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF2306 PF10067.4 ESL04926.1 - 0.17 11.9 1.9 0.21 11.7 0.5 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) DUF2207 PF09972.4 ESL04926.1 - 0.32 9.5 2.0 0.34 9.4 1.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SCAMP PF04144.8 ESL04926.1 - 2.5 7.9 9.5 5.8 6.7 6.7 1.6 1 1 0 1 1 1 0 SCAMP family TMEM151 PF14857.1 ESL04927.1 - 0.14 10.7 0.1 0.12 10.9 0.1 1.1 1 0 0 1 1 1 0 TMEM151 family Mito_fiss_reg PF05308.6 ESL04930.1 - 0.023 14.0 1.5 0.028 13.7 1.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Dscam_C PF12355.3 ESL04930.1 - 0.11 12.7 1.6 0.13 12.5 1.1 1.2 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Tcf25 PF04910.9 ESL04936.1 - 0.055 12.4 0.0 0.056 12.3 0.0 1.0 1 0 0 1 1 1 0 Transcriptional repressor TCF25 PBP1_TM PF14812.1 ESL04937.1 - 3.2 8.1 7.3 4.6 7.6 0.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PsbI PF02532.9 ESL04941.1 - 0.32 10.6 3.0 0.69 9.5 2.1 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) MFS_1 PF07690.11 ESL04949.1 - 0.08 11.6 0.1 0.087 11.5 0.1 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF3987 PF13148.1 ESL04950.1 - 3.5 6.0 10.7 4.2 5.8 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF3464 PF11947.3 ESL04950.1 - 7.3 6.0 7.3 8.7 5.7 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) DUF2217 PF10265.4 ESL04953.1 - 0.025 13.3 0.4 0.027 13.2 0.3 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) NOZZLE PF08744.5 ESL04953.1 - 0.083 12.2 0.1 0.086 12.1 0.1 1.0 1 0 0 1 1 1 0 Plant transcription factor NOZZLE DsbD_2 PF13386.1 ESL04956.1 - 0.05 13.3 1.5 0.054 13.2 1.0 1.1 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region NAD_binding_6 PF08030.7 ESL04957.1 - 0.091 12.6 5.1 0.12 12.2 3.5 1.1 1 0 0 1 1 1 0 Ferric reductase NAD binding domain DUF2390 PF09523.5 ESL04957.1 - 0.12 12.5 0.1 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) DUF1764 PF08576.5 ESL04957.1 - 9.6 7.0 10.6 14 6.5 7.3 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) SelP_N PF04592.9 ESL04958.1 - 5.1 6.4 8.5 4.9 6.4 5.9 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CoA_binding_3 PF13727.1 ESL04959.1 - 7.4 6.3 6.9 10 5.9 4.8 1.1 1 0 0 1 1 1 0 CoA-binding domain Paf67 PF10255.4 ESL04963.1 - 0.013 14.3 0.5 0.015 14.2 0.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 DUF4638 PF15472.1 ESL04963.1 - 0.71 9.4 4.5 0.73 9.3 3.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Peptidase_S30 PF01577.11 ESL04963.1 - 5.6 6.2 7.4 6.2 6.1 5.2 1.0 1 0 0 1 1 1 0 Potyvirus P1 protease Deltaretro_Tax PF05599.6 ESL04965.1 - 0.02 15.2 1.6 0.025 14.8 1.1 1.3 1 1 0 1 1 1 0 Deltaretrovirus Tax protein GCM PF03615.10 ESL04966.1 - 0.0087 15.6 2.1 0.011 15.3 1.5 1.1 1 0 0 1 1 1 1 GCM motif protein DUF4131 PF13567.1 ESL04967.1 - 7.6 5.9 8.9 9.5 5.5 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3667 PF12412.3 ESL04971.1 - 0.0066 15.7 1.7 0.011 15.0 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3667) DEADboxA PF12343.3 ESL04971.1 - 6.1 7.1 6.0 1.3 9.3 1.1 1.9 2 0 0 2 2 2 0 Cold shock protein DEAD box A MASE2 PF05230.6 ESL04977.1 - 0.023 14.6 0.1 0.036 14.0 0.1 1.3 1 0 0 1 1 1 0 MASE2 domain DUF2306 PF10067.4 ESL04980.1 - 1.3 9.1 4.5 0.18 11.9 0.6 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2306) Plasmodium_Vir PF05795.6 ESL04983.1 - 0.15 11.2 0.7 0.15 11.2 0.5 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ABC2_membrane_3 PF12698.2 ESL04986.1 - 0.2 10.6 6.6 0.25 10.3 4.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4131 PF13567.1 ESL04986.1 - 1.3 8.4 4.5 1.5 8.2 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) MRAP PF15183.1 ESL04986.1 - 1.5 8.4 4.5 1.1 8.8 0.4 2.0 1 1 1 2 2 2 0 Melanocortin-2 receptor accessory protein family RGM_N PF06535.7 ESL04987.1 - 0.023 14.7 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus DAGK_cat PF00781.19 ESL04987.1 - 0.042 13.2 0.2 0.063 12.7 0.1 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Cad PF03596.8 ESL04989.1 - 0.0087 15.7 0.5 0.011 15.4 0.3 1.1 1 0 0 1 1 1 1 Cadmium resistance transporter Phtf-FEM1B_bdg PF12129.3 ESL04989.1 - 0.094 12.0 1.4 0.11 11.8 1.0 1.2 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor DUF3435 PF11917.3 ESL04990.1 - 0.54 8.9 4.1 0.85 8.2 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) YgbA_NO PF11756.3 ESL04991.1 - 0.016 15.2 0.2 0.02 14.9 0.1 1.1 1 0 0 1 1 1 0 Nitrous oxide-stimulated promoter MtN3_slv PF03083.11 ESL04991.1 - 0.17 11.7 0.5 0.29 11.0 0.3 1.3 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange EF-hand_7 PF13499.1 ESL04995.1 - 0.0024 17.9 0.0 0.0028 17.7 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.1 ESL04995.1 - 0.0027 17.5 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain DUF4117 PF13491.1 ESL04997.1 - 0.24 10.8 1.8 0.26 10.6 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4117) DUF4131 PF13567.1 ESL04997.1 - 0.92 8.8 4.9 0.94 8.8 3.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) OPT PF03169.10 ESL05002.1 - 0.091 11.1 2.1 0.1 11.0 1.5 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein Gemini_mov PF01708.11 ESL05003.1 - 0.062 12.8 4.2 2.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Geminivirus putative movement protein DUF2721 PF11026.3 ESL05003.1 - 0.23 11.1 0.0 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF912 PF06024.7 ESL05003.1 - 0.3 11.1 2.4 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) mRNA_triPase PF02940.10 ESL05004.1 - 2.9e-10 40.2 0.0 9.3e-10 38.5 0.0 1.7 1 1 0 1 1 1 1 mRNA capping enzyme, beta chain 60KD_IMP PF02096.15 ESL05006.1 - 0.053 13.1 0.2 0.053 13.1 0.1 1.1 1 0 0 1 1 1 0 60Kd inner membrane protein MarC PF01914.12 ESL05006.1 - 0.061 12.4 0.0 0.068 12.2 0.0 1.0 1 0 0 1 1 1 0 MarC family integral membrane protein SCF PF02404.10 ESL05006.1 - 0.098 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Stem cell factor Oxidored_q3 PF00499.15 ESL05006.1 - 0.12 12.1 2.9 0.14 11.8 2.0 1.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 UPF0220 PF05255.6 ESL05008.1 - 0.00031 20.0 0.2 0.00034 19.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF4094 PF13334.1 ESL05010.1 - 0.18 12.2 0.9 0.78 10.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) EI24 PF07264.6 ESL05013.1 - 0.15 11.4 5.5 0.17 11.3 3.8 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF4285 PF14113.1 ESL05015.1 - 0.045 13.7 0.7 0.053 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4285) GD_AH_C PF04295.8 ESL05015.1 - 0.22 10.1 1.4 0.26 9.9 1.0 1.0 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus PCI PF01399.22 ESL05017.1 - 0.1 12.9 0.1 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 PCI domain Mucin PF01456.12 ESL05022.1 - 0.13 12.0 3.6 0.17 11.6 2.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein ABC2_membrane_4 PF12730.2 ESL05025.1 - 7.5 5.6 12.7 1.2 8.1 5.9 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein DnaJ PF00226.26 ESL05029.1 - 1.9e-08 33.9 0.0 3.5e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain ATP-synt_8 PF00895.15 ESL05035.1 - 0.67 10.1 4.0 1.6 9.0 2.8 1.6 1 1 0 1 1 1 0 ATP synthase protein 8 DPM2 PF07297.7 ESL05035.1 - 9 6.6 7.2 26 5.1 5.0 1.8 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF1560 PF07597.6 ESL05042.1 - 0.12 12.3 0.2 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1560) Se-cys_synth_N PF12390.3 ESL05043.1 - 0.065 13.3 0.0 17 5.6 0.0 2.3 2 0 0 2 2 2 0 Selenocysteine synthase N terminal DNA_pol_phi PF04931.8 ESL05043.1 - 0.2 9.3 1.9 2.5 5.7 0.1 2.0 2 0 0 2 2 2 0 DNA polymerase phi DUF1180 PF06679.7 ESL05045.1 - 0.075 12.9 0.1 0.097 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) ATG22 PF11700.3 ESL05045.1 - 0.18 10.2 0.0 0.21 10.0 0.0 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Strabismus PF06638.6 ESL05047.1 - 6.5 4.9 6.5 8.5 4.5 4.5 1.1 1 0 0 1 1 1 0 Strabismus protein DUF340 PF03956.8 ESL05048.1 - 0.028 13.6 0.5 0.029 13.6 0.3 1.1 1 0 0 1 1 1 0 Membrane protein of unknown function (DUF340) DUF2463 PF09591.5 ESL05048.1 - 0.084 12.4 4.3 0.089 12.3 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) YrzO PF14142.1 ESL05048.1 - 0.097 12.3 1.0 0.19 11.3 0.7 1.5 1 0 0 1 1 1 0 YrzO-like protein MerT PF02411.10 ESL05050.1 - 0.036 13.8 0.6 0.041 13.6 0.4 1.2 1 0 0 1 1 1 0 MerT mercuric transport protein MrpF_PhaF PF04066.8 ESL05050.1 - 0.051 13.8 0.8 0.064 13.5 0.6 1.2 1 0 0 1 1 1 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) DUF2628 PF10947.3 ESL05050.1 - 0.15 11.8 1.9 0.19 11.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) DUF2142 PF09913.4 ESL05050.1 - 0.16 10.6 2.1 0.17 10.5 1.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) OapA_N PF08525.6 ESL05052.1 - 0.28 11.0 2.9 0.39 10.5 2.0 1.3 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif DUF3262 PF11660.3 ESL05053.1 - 4.5 7.4 6.4 6.1 7.0 4.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3262) DctQ PF04290.7 ESL05055.1 - 0.2 11.4 3.0 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Methyltransf_11 PF08241.7 ESL05056.1 - 4.7e-07 30.2 0.0 8.5e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL05056.1 - 0.00091 18.9 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESL05056.1 - 0.0026 17.3 0.0 0.0052 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 ESL05056.1 - 0.0034 16.9 0.0 0.0061 16.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL05056.1 - 0.017 15.1 0.0 0.061 13.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 ESL05056.1 - 0.018 14.1 0.1 0.026 13.6 0.1 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 ESL05056.1 - 0.029 13.5 0.0 0.038 13.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESL05056.1 - 0.048 14.2 0.0 0.11 13.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 ESL05056.1 - 0.086 13.2 0.1 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Tetraspannin PF00335.15 ESL05059.1 - 3.5e-11 42.8 9.8 5.5e-11 42.1 6.8 1.3 1 0 0 1 1 1 1 Tetraspanin family Herpes_BMRF2 PF04633.7 ESL05060.1 - 0.026 13.5 2.3 0.031 13.2 1.6 1.1 1 0 0 1 1 1 0 Herpesvirus BMRF2 protein FAM176 PF14851.1 ESL05061.1 - 0.14 11.8 0.3 0.19 11.4 0.2 1.2 1 0 0 1 1 1 0 FAM176 family NADH_B2 PF14813.1 ESL05062.1 - 0.084 12.5 2.1 0.11 12.1 1.5 1.2 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 DUF594 PF04578.8 ESL05062.1 - 0.15 11.5 2.3 0.23 10.9 1.6 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF594 DUF123 PF01986.11 ESL05062.1 - 3.4 7.8 8.7 5.8 7.1 6.0 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF123 DUF740 PF05340.7 ESL05062.1 - 3.7 5.8 6.6 3.8 5.7 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) LETM1 PF07766.8 ESL05063.1 - 8.8e-07 28.2 0.0 1.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 LETM1-like protein CDP-OH_P_tran_2 PF08009.6 ESL05065.1 - 1.3 8.8 6.4 0.2 11.3 1.0 2.1 2 1 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 DUF2417 PF10329.4 ESL05066.1 - 0.16 11.3 9.7 0.16 11.3 6.7 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF2207 PF09972.4 ESL05066.1 - 2.5 6.6 5.1 3.1 6.2 3.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SET PF00856.23 ESL05067.1 - 2.9e-07 30.9 0.0 0.00038 20.7 0.0 2.4 1 1 0 1 1 1 1 SET domain Cut8_N PF14482.1 ESL05067.1 - 0.15 12.0 2.7 0.31 11.0 1.9 1.4 1 0 0 1 1 1 0 Cut8 proteasome-binding domain Vma12 PF11712.3 ESL05069.1 - 0.057 13.1 0.3 0.11 12.1 0.2 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase ESCRT-II PF05871.7 ESL05070.1 - 1.2e-12 47.8 0.0 3.2e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 ESCRT-II complex subunit TMPIT PF07851.8 ESL05070.1 - 0.37 9.8 1.9 0.5 9.3 1.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4409 PF14365.1 ESL05071.1 - 0.039 14.1 3.0 0.042 14.0 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4409) zf-H2C2_5 PF13909.1 ESL05071.1 - 0.71 10.2 5.2 5.6 7.4 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF4131 PF13567.1 ESL05072.1 - 0.31 10.4 1.8 0.36 10.2 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) UPF0203 PF05254.7 ESL05073.1 - 0.00062 19.5 6.6 2.5 8.0 0.1 3.5 3 0 0 3 3 3 3 Uncharacterised protein family (UPF0203) COX6B PF02297.12 ESL05073.1 - 0.0064 16.4 2.9 0.0064 16.4 2.0 2.8 1 1 1 2 2 2 1 Cytochrome oxidase c subunit VIb Complex1_LYR PF05347.10 ESL05073.1 - 0.01 15.6 0.2 0.035 13.9 0.1 2.0 1 0 0 1 1 1 0 Complex 1 protein (LYR family) DUF4475 PF14753.1 ESL05073.1 - 0.11 11.9 6.4 0.16 11.4 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4475) Pet191_N PF10203.4 ESL05073.1 - 0.23 11.5 6.2 0.67 10.0 0.7 2.6 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DUF3369 PF11849.3 ESL05073.1 - 0.31 10.9 2.3 0.2 11.5 0.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3369) CHCH PF06747.8 ESL05073.1 - 0.35 10.8 3.7 10 6.1 0.4 3.2 2 1 0 2 2 2 0 CHCH domain Cytochrom_C1 PF02167.10 ESL05074.1 - 0.075 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C1 family TAN PF11640.3 ESL05074.1 - 0.1 12.3 0.4 1.3 8.7 0.0 2.7 2 2 1 3 3 3 0 Telomere-length maintenance and DNA damage repair Potassium_chann PF11404.3 ESL05075.1 - 0.25 11.1 2.1 0.38 10.5 1.4 1.3 1 0 0 1 1 1 0 Potassium voltage-gated channel FWWh PF14922.1 ESL05076.1 - 0.04 13.4 0.1 0.05 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF4149 PF13664.1 ESL05080.1 - 0.33 11.0 2.8 0.43 10.6 0.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) DUF1212 PF06738.7 ESL05080.1 - 2.9 7.3 5.7 0.28 10.6 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1212) 7tm_6 PF02949.15 ESL05081.1 - 0.023 13.5 1.1 0.024 13.5 0.8 1.0 1 0 0 1 1 1 0 7tm Odorant receptor DUF2180 PF09947.4 ESL05085.1 - 0.071 12.8 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) DUF2919 PF11143.3 ESL05087.1 - 0.032 14.0 0.2 0.038 13.8 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) 7TM-7TMR_HD PF07698.6 ESL05088.1 - 0.86 9.0 17.9 1.1 8.6 12.4 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF4199 PF13858.1 ESL05090.1 - 0.026 14.4 1.9 0.026 14.4 1.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF3593 PF12159.3 ESL05090.1 - 0.92 9.3 3.7 1.3 8.8 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3593) MRAP PF15183.1 ESL05090.1 - 3.1 7.4 5.0 0.93 9.1 1.1 1.8 1 1 1 2 2 2 0 Melanocortin-2 receptor accessory protein family GASA PF02704.9 ESL05091.1 - 0.031 14.2 4.4 0.042 13.8 3.0 1.3 1 0 0 1 1 1 0 Gibberellin regulated protein DHC PF09626.5 ESL05092.1 - 0.072 13.7 0.2 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 Dihaem cytochrome c Methyltransf_29 PF03141.11 ESL05092.1 - 0.081 11.2 0.3 0.11 10.7 0.2 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF2614 PF11023.3 ESL05094.1 - 0.096 12.4 1.8 0.11 12.3 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2614) DAP10 PF07213.6 ESL05094.1 - 4.5 7.1 6.0 0.4 10.4 0.3 2.1 2 1 0 2 2 2 0 DAP10 membrane protein AgrB PF04647.10 ESL05095.1 - 0.012 14.6 0.3 0.012 14.6 0.2 2.4 3 0 0 3 3 3 0 Accessory gene regulator B DUF2140 PF09911.4 ESL05095.1 - 0.022 13.9 0.2 0.31 10.1 0.0 2.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) MarC PF01914.12 ESL05095.1 - 0.079 12.0 0.0 0.26 10.3 0.0 1.8 2 1 0 2 2 2 0 MarC family integral membrane protein Tr-sialidase_C PF11052.3 ESL05095.1 - 0.23 11.3 3.8 0.51 10.2 2.6 1.5 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3328 PF11807.3 ESL05095.1 - 0.41 10.2 3.9 3.1 7.4 0.3 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF3328) 7tm_1 PF00001.16 ESL05095.1 - 0.98 8.5 5.6 14 4.6 3.9 2.2 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7tm_7 PF08395.7 ESL05095.1 - 8.7 5.2 14.3 7 5.5 5.4 2.1 2 0 0 2 2 2 0 7tm Chemosensory receptor DUF791 PF05631.9 ESL05096.1 - 6.9e-84 281.5 12.9 1.1e-83 280.8 8.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 ESL05096.1 - 5.7e-06 25.2 49.1 0.0038 15.9 13.6 2.9 1 1 2 3 3 3 2 Major Facilitator Superfamily HAMP PF00672.20 ESL05096.1 - 9.7 6.4 10.8 4.4 7.5 0.1 3.8 3 1 1 4 4 4 0 HAMP domain ARF7EP_C PF14949.1 ESL05097.1 - 0.017 15.5 1.4 0.027 14.9 0.2 1.8 2 0 0 2 2 2 0 ARF7 effector protein C-terminus ATG27 PF09451.5 ESL05097.1 - 0.029 13.6 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 Autophagy-related protein 27 NapE PF06796.6 ESL05097.1 - 0.52 9.6 2.7 0.39 10.0 0.2 2.0 1 1 1 2 2 2 0 Periplasmic nitrate reductase protein NapE OST3_OST6 PF04756.8 ESL05098.1 - 0.18 11.3 6.0 0.21 11.1 4.2 1.2 1 0 0 1 1 1 0 OST3 / OST6 family DUF3366 PF11846.3 ESL05098.1 - 1.4 8.7 5.7 1.6 8.6 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) DUF2142 PF09913.4 ESL05098.1 - 6.1 5.4 10.2 6.6 5.2 7.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) PalH PF08733.5 ESL05098.1 - 6.7 5.4 8.9 7 5.3 6.2 1.1 1 0 0 1 1 1 0 PalH/RIM21 Aminotran_4 PF01063.14 ESL05101.1 - 4.3e-21 75.4 0.0 6.3e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV 2OG-FeII_Oxy_2 PF13532.1 ESL05102.1 - 1.6e-12 47.6 0.0 2.4e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESL05102.1 - 1e-06 28.9 0.0 3.3e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 ESL05102.1 - 0.061 13.8 0.0 0.23 12.0 0.0 1.9 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF106 PF01956.11 ESL05104.1 - 0.017 14.6 0.3 0.018 14.5 0.2 1.0 1 0 0 1 1 1 0 Integral membrane protein DUF106 7TM_GPCR_Srb PF02175.11 ESL05104.1 - 0.094 12.2 0.2 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srb DUF916 PF06030.7 ESL05104.1 - 8.2 6.2 10.5 2.8 7.7 5.7 1.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) Cwf_Cwc_15 PF04889.7 ESL05107.1 - 0.085 12.5 3.2 0.1 12.3 2.2 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-CCCH PF00642.19 ESL05110.1 - 9.3e-08 31.5 7.2 0.00029 20.4 1.7 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHC PF00098.18 ESL05110.1 - 1.4e-06 27.9 0.5 1.4e-06 27.9 0.3 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESL05110.1 - 0.00015 21.1 0.8 0.00029 20.2 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle RRM_1 PF00076.17 ESL05110.1 - 0.0083 15.7 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_4 PF14392.1 ESL05110.1 - 0.089 12.4 1.8 0.22 11.2 1.2 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.1 ESL05110.1 - 0.15 11.8 4.6 0.5 10.1 0.2 2.8 3 0 0 3 3 3 0 Zinc knuckle Apis_Csd PF11671.3 ESL05110.1 - 0.21 11.3 5.6 0.73 9.6 3.1 2.0 2 0 0 2 2 2 0 Complementary sex determiner protein LRV_FeS PF05484.6 ESL05110.1 - 1.8 8.1 5.8 15 5.2 0.3 2.5 2 0 0 2 2 2 0 LRV protein FeS4 cluster UPF0561 PF10573.4 ESL05111.1 - 1.6 8.5 5.6 0.33 10.7 1.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 DUF3953 PF13129.1 ESL05112.1 - 0.11 12.0 0.2 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) Glucan_synthase PF02364.10 ESL05114.1 - 7.5 4.2 7.7 8.6 4.0 5.3 1.0 1 0 0 1 1 1 0 1,3-beta-glucan synthase component Macro PF01661.16 ESL05115.1 - 2.9e-29 101.3 0.0 4.1e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Macro domain DUF1265 PF06887.9 ESL05115.1 - 0.026 14.2 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) PALP PF00291.20 ESL05124.1 - 0.0091 15.2 0.0 0.0091 15.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4626 PF15422.1 ESL05125.1 - 0.0084 16.0 1.7 0.0096 15.8 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4626) UCH_1 PF13423.1 ESL05127.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Acp26Ab PF05777.7 ESL05127.1 - 0.026 14.9 0.0 0.071 13.5 0.0 1.7 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) vMSA PF00695.14 ESL05128.1 - 2.2 7.4 5.7 2.3 7.3 4.0 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Rrn6 PF10214.4 ESL05128.1 - 7.1 4.5 10.7 7 4.6 7.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SelR PF01641.13 ESL05130.1 - 0.0024 17.5 0.0 0.011 15.4 0.0 2.1 1 1 0 1 1 1 1 SelR domain Exosortase_EpsH PF09721.5 ESL05131.1 - 0.36 9.9 3.0 0.39 9.8 2.1 1.0 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) YqaJ PF09588.5 ESL05132.1 - 2.4e-39 134.7 0.0 3.7e-39 134.1 0.0 1.3 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain Mucin PF01456.12 ESL05134.1 - 0.00046 19.9 4.8 0.00046 19.9 3.3 1.8 2 0 0 2 2 2 1 Mucin-like glycoprotein ABC2_membrane_4 PF12730.2 ESL05135.1 - 0.0012 18.0 0.4 0.0014 17.7 0.3 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Bromodomain PF00439.20 ESL05138.1 - 1.7e-14 53.4 0.0 2.6e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain Cas1_AcylT PF07779.7 ESL05139.1 - 4.8e-64 216.6 33.3 5.4e-64 216.4 20.9 2.3 1 1 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p HemY_N PF07219.8 ESL05140.1 - 0.031 13.8 0.1 0.039 13.4 0.1 1.1 1 0 0 1 1 1 0 HemY protein N-terminus Fe-ADH PF00465.14 ESL05141.1 - 1.8e-47 161.7 0.7 2.3e-47 161.3 0.5 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 ESL05141.1 - 2.5e-25 89.2 0.0 3.1e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.15 ESL05141.1 - 6.3e-05 22.0 0.1 0.084 11.7 0.1 2.2 2 0 0 2 2 2 2 3-dehydroquinate synthase Colipase_C PF02740.9 ESL05141.1 - 0.13 12.0 0.5 0.27 10.9 0.4 1.5 1 0 0 1 1 1 0 Colipase, C-terminal domain PPR_2 PF13041.1 ESL05142.1 - 1.9e-23 82.1 7.4 4.1e-07 29.8 0.1 7.2 4 2 3 7 7 7 6 PPR repeat family PPR_3 PF13812.1 ESL05142.1 - 9.2e-12 44.2 15.2 0.042 14.1 0.0 9.3 10 1 0 10 10 10 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESL05142.1 - 4.8e-06 25.9 1.4 0.0039 16.6 0.0 5.2 6 0 0 6 6 6 1 PPR repeat PPR PF01535.15 ESL05142.1 - 2.8e-05 23.8 12.2 0.0015 18.4 0.1 7.5 9 1 0 9 9 9 1 PPR repeat RPM2 PF08579.6 ESL05142.1 - 0.00073 19.6 1.8 33 4.6 0.0 5.3 4 3 2 6 6 6 0 Mitochondrial ribonuclease P subunit (RPM2) ECSIT PF06239.6 ESL05142.1 - 0.041 12.7 3.1 4 6.2 0.2 4.1 2 2 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway DAG_kinase_N PF14513.1 ESL05142.1 - 0.1 12.8 0.6 1.4 9.1 0.1 2.3 1 1 1 2 2 2 0 Diacylglycerol kinase N-terminus Exostosin PF03016.10 ESL05145.1 - 0.085 11.8 0.0 0.096 11.7 0.0 1.0 1 0 0 1 1 1 0 Exostosin family zf-U1 PF06220.7 ESL05147.1 - 0.021 14.3 14.4 0.18 11.3 0.1 4.5 4 0 0 4 4 4 0 U1 zinc finger SET PF00856.23 ESL05150.1 - 0.11 12.7 0.1 19 5.4 0.0 2.9 2 1 0 2 2 2 0 SET domain DUF1738 PF08401.6 ESL05153.1 - 4.9e-07 29.5 0.0 0.0035 17.0 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF1738) Peptidase_M50B PF13398.1 ESL05155.1 - 0.067 12.5 0.5 0.076 12.3 0.3 1.2 1 0 0 1 1 1 0 Peptidase M50B-like SapA PF02199.10 ESL05156.1 - 0.076 12.7 0.6 0.16 11.7 0.4 1.6 1 0 0 1 1 1 0 Saposin A-type domain YopE PF03545.8 ESL05156.1 - 0.093 12.6 1.8 0.1 12.5 0.3 1.7 1 1 1 2 2 2 0 Yersinia virulence determinant (YopE) IncA PF04156.9 ESL05156.1 - 0.69 9.4 6.1 0.83 9.2 4.3 1.1 1 0 0 1 1 1 0 IncA protein RasGEF PF00617.14 ESL05157.1 - 1.6e-20 73.6 0.0 3.2e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 ESL05157.1 - 0.00039 20.4 1.5 0.00092 19.2 0.2 2.3 3 0 0 3 3 3 1 RasGEF N-terminal motif DUF3395 PF11875.3 ESL05163.1 - 1.4e-46 157.8 0.0 2.1e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) EGF PF00008.22 ESL05164.1 - 0.3 11.0 4.9 2 8.4 1.3 2.3 2 0 0 2 2 2 0 EGF-like domain DUF3888 PF13027.1 ESL05166.1 - 0.071 12.9 0.2 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) WD40 PF00400.27 ESL05173.1 - 1.8e-06 27.5 7.9 0.15 11.9 0.1 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat peroxidase PF00141.18 ESL05174.1 - 5.9e-06 25.9 0.0 1.2e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Peroxidase LRR_4 PF12799.2 ESL05175.1 - 1.7e-11 43.4 22.7 0.11 12.0 0.1 8.4 7 2 1 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL05175.1 - 1.1e-10 40.4 31.8 0.062 13.3 0.0 11.4 13 0 0 13 13 13 5 Leucine Rich repeat LRR_1 PF00560.28 ESL05175.1 - 4.7e-07 28.9 16.1 15 6.0 0.0 10.7 10 2 1 11 11 11 2 Leucine Rich Repeat Vfa1 PF08432.5 ESL05175.1 - 0.37 10.7 24.4 0.13 12.3 14.4 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SDA1 PF05285.7 ESL05175.1 - 0.71 9.0 36.1 0.44 9.7 19.7 2.4 2 0 0 2 2 2 0 SDA1 LRR_7 PF13504.1 ESL05175.1 - 1 9.8 30.2 7.1 7.3 0.2 10.1 12 0 0 12 12 12 0 Leucine rich repeat DUF2413 PF10310.4 ESL05175.1 - 1.8 7.3 22.7 3.5 6.3 15.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) RHSP PF07999.6 ESL05178.1 - 1.5e-86 290.7 0.6 2.1e-86 290.2 0.4 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESL05178.1 - 0.088 12.9 0.0 0.86 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 ESL05178.1 - 0.22 10.9 0.7 1.4 8.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain Extensin_2 PF04554.8 ESL05179.1 - 2.9e-09 36.6 89.4 6.2e-06 25.9 31.6 3.5 1 1 1 2 2 2 2 Extensin-like region Pro-rich PF15240.1 ESL05179.1 - 7.4e-05 22.9 35.0 9.1e-05 22.6 24.3 1.2 1 0 0 1 1 1 1 Proline-rich DUF3481 PF11980.3 ESL05179.1 - 0.0071 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3481) Herpes_gE PF02480.11 ESL05179.1 - 0.014 13.7 0.0 0.018 13.3 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF3040 PF11239.3 ESL05179.1 - 0.021 14.8 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) TMEM154 PF15102.1 ESL05179.1 - 0.091 12.4 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family MbeD_MobD PF04899.7 ESL05180.1 - 0.38 10.6 4.5 1.1 9.2 0.1 2.8 3 0 0 3 3 3 0 MbeD/MobD like Acyl-CoA_ox_N PF14749.1 ESL05180.1 - 5.7 7.2 6.9 1.4 9.2 0.1 2.8 2 1 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Nucleoside_tran PF01733.13 ESL05184.1 - 3.3e-10 39.6 1.5 6.3e-10 38.7 0.0 1.9 2 0 0 2 2 2 1 Nucleoside transporter DUF951 PF06107.6 ESL05184.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) Claudin_2 PF13903.1 ESL05184.1 - 2.4 7.8 8.3 0.53 9.9 2.3 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction BNR_3 PF13859.1 ESL05185.1 - 3.8e-50 170.7 0.0 3.8e-50 170.7 0.0 1.7 3 0 0 3 3 3 1 BNR repeat-like domain Peptidase_M8 PF01457.11 ESL05186.1 - 3.1e-128 428.4 0.0 3.8e-128 428.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_3 PF13582.1 ESL05186.1 - 0.0019 18.7 0.0 0.0042 17.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 ESL05186.1 - 0.079 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 GSHPx PF00255.14 ESL05187.1 - 5.5e-40 135.0 0.2 7.1e-40 134.7 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 ESL05187.1 - 1.9e-07 30.7 0.0 3.4e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESL05187.1 - 8.7e-05 22.0 0.0 0.00018 21.0 0.0 1.6 1 1 0 1 1 1 1 Redoxin Lipoprotein_15 PF03640.10 ESL05187.1 - 0.11 11.9 0.1 1.5 8.3 0.0 2.6 3 0 0 3 3 3 0 Secreted repeat of unknown function DUF423 PF04241.10 ESL05188.1 - 2.9e-21 75.1 3.5 2.9e-21 75.1 2.4 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF423) NfeD PF01957.13 ESL05188.1 - 0.076 13.1 0.4 0.076 13.1 0.3 2.1 2 1 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF1761 PF08570.5 ESL05188.1 - 0.48 10.4 5.9 0.12 12.3 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1761) Aa_trans PF01490.13 ESL05189.1 - 8.3e-40 136.5 26.0 1.2e-39 136.0 18.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Methyltransf_16 PF10294.4 ESL05189.1 - 0.039 13.3 0.0 0.11 11.8 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Ribosomal_L21e PF01157.13 ESL05190.1 - 2.1e-36 123.6 2.3 3e-36 123.1 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e Peptidase_M16_C PF05193.16 ESL05191.1 - 6.2e-09 35.7 0.0 0.00057 19.6 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ESL05191.1 - 6.3e-07 29.2 0.1 1.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) EspA PF03433.8 ESL05191.1 - 0.28 10.6 0.0 0.5 9.7 0.0 1.3 1 0 0 1 1 1 0 EspA-like secreted protein DUF2910 PF11139.3 ESL05192.1 - 0.0025 16.9 0.0 0.0026 16.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2910) BatA PF07584.6 ESL05192.1 - 0.077 13.2 0.0 0.45 10.7 0.0 1.9 1 1 0 1 1 1 0 Aerotolerance regulator N-terminal Imm_superinfect PF14373.1 ESL05192.1 - 0.088 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Superinfection immunity protein DUF3366 PF11846.3 ESL05192.1 - 0.099 12.5 0.1 0.2 11.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3366) Lig_chan PF00060.21 ESL05192.1 - 0.11 12.2 0.1 0.35 10.5 0.0 1.7 1 1 1 2 2 2 0 Ligand-gated ion channel DUF2029 PF09594.5 ESL05192.1 - 0.12 11.8 0.3 0.18 11.2 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2029) Aa_trans PF01490.13 ESL05193.1 - 2.5e-38 131.6 28.0 2.8e-38 131.4 19.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL05193.1 - 0.00018 20.4 9.1 0.00018 20.4 6.3 2.2 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Mito_carr PF00153.22 ESL05194.1 - 5.4e-69 227.9 4.9 1.5e-25 88.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF4257 PF14074.1 ESL05194.1 - 0.00092 18.8 0.0 0.68 9.6 0.1 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF4257) Nodulin-like PF06813.8 ESL05195.1 - 1.5e-12 47.3 15.3 1.5e-12 47.3 10.6 2.6 2 1 0 2 2 2 2 Nodulin-like DGF-1_5 PF11038.3 ESL05198.1 - 1.3e-102 342.7 10.9 2e-102 342.1 7.6 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 BNR_3 PF13859.1 ESL05199.1 - 6.4e-56 189.6 0.0 8e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05199.1 - 1e-05 24.9 0.1 1.8e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESL05199.1 - 0.061 13.1 1.4 7.5 6.8 0.2 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat Abhydrolase_5 PF12695.2 ESL05200.1 - 2.9e-15 56.3 0.0 5.6e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL05200.1 - 2.9e-08 33.8 0.0 6.3e-06 26.2 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESL05200.1 - 4e-07 29.4 0.0 8.5e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 ESL05200.1 - 3.1e-06 26.9 0.0 5.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PEX-2N PF09263.5 ESL05200.1 - 0.0021 18.3 0.1 0.7 10.2 0.0 2.8 3 0 0 3 3 3 1 Peroxisome biogenesis factor 1, N-terminal DUF818 PF05677.7 ESL05200.1 - 0.0022 16.7 0.0 0.0035 16.1 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) DLH PF01738.13 ESL05200.1 - 0.011 14.9 0.0 0.061 12.5 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Topoisom_bac PF01131.15 ESL05201.1 - 4.4e-93 312.2 0.0 5.8e-93 311.8 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 ESL05201.1 - 1.8e-14 53.5 0.0 3.2e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Metallophos PF00149.23 ESL05203.1 - 0.0022 17.4 0.1 0.0099 15.2 0.0 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase SKG6 PF08693.5 ESL05203.1 - 0.048 12.9 3.6 0.12 11.6 2.5 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF3926 PF13080.1 ESL05203.1 - 0.052 13.0 0.6 7.1 6.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) TMEM154 PF15102.1 ESL05203.1 - 0.094 12.4 0.0 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family SIT PF15330.1 ESL05203.1 - 0.46 10.6 0.0 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Peptidase_M8 PF01457.11 ESL05204.1 - 5.1e-17 61.4 2.0 2.3e-15 55.9 1.4 2.0 1 1 0 1 1 1 1 Leishmanolysin Ribosomal_L22 PF00237.14 ESL05205.1 - 1.1e-30 105.6 0.2 1.4e-30 105.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e EMP70 PF02990.11 ESL05208.1 - 2e-146 488.5 8.4 2.6e-146 488.1 5.8 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Ribosomal_S17 PF00366.15 ESL05209.1 - 1.7e-22 79.2 0.6 2.1e-22 78.9 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 DUF3405 PF11885.3 ESL05210.1 - 1.1 7.4 6.3 1.2 7.2 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Peripla_BP_6 PF13458.1 ESL05211.1 - 2.3e-13 50.2 3.1 1.9e-09 37.3 0.1 2.5 2 0 0 2 2 2 2 Periplasmic binding protein DUF3819 PF12842.2 ESL05212.1 - 1.2e-27 96.4 2.1 3.4e-27 94.9 1.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) Nodulin-like PF06813.8 ESL05213.1 - 6.1e-12 45.3 20.6 1.1e-10 41.1 14.3 2.0 1 1 0 1 1 1 1 Nodulin-like MFS_1 PF07690.11 ESL05213.1 - 9.4e-12 44.3 25.7 9.4e-12 44.3 17.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Pox_A14 PF05767.7 ESL05213.1 - 8.3 6.4 7.7 1 9.3 0.7 2.9 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 Peptidase_M20 PF01546.23 ESL05215.1 - 2.2e-20 72.9 0.0 4.1e-20 72.0 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL05215.1 - 4.3e-13 48.9 0.0 6.9e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain ADIP PF11559.3 ESL05216.1 - 0.039 13.8 2.3 0.067 13.0 1.6 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding GCIP PF13324.1 ESL05216.1 - 0.11 11.6 0.1 3.4 6.8 0.0 2.1 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting DUF2984 PF11203.3 ESL05216.1 - 0.27 11.3 2.6 0.37 10.9 0.4 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2984) TBPIP PF07106.8 ESL05216.1 - 0.36 10.3 2.0 1.4 8.4 0.5 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PHO4 PF01384.15 ESL05217.1 - 1.2e-105 352.7 25.6 1.6e-105 352.3 17.8 1.1 1 0 0 1 1 1 1 Phosphate transporter family Myco_arth_vir_N PF09610.5 ESL05217.1 - 0.08 12.9 0.4 0.68 9.9 0.0 2.9 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimer_Tnp_hAT PF05699.9 ESL05217.1 - 0.11 12.1 1.2 0.94 9.1 0.0 2.3 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Enolase_C PF00113.17 ESL05219.1 - 1.7e-134 447.4 0.0 2.3e-134 446.9 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 ESL05219.1 - 1.2e-57 193.5 0.0 2e-57 192.7 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 ESL05219.1 - 6.9e-05 22.7 0.0 0.00018 21.4 0.0 1.7 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.6 ESL05219.1 - 0.0035 16.3 0.6 0.0062 15.4 0.1 1.6 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus MR_MLE PF01188.16 ESL05219.1 - 0.024 15.1 0.0 0.065 13.7 0.0 1.8 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Sugar_tr PF00083.19 ESL05220.1 - 1e-82 278.1 27.7 1.2e-81 274.5 19.2 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL05220.1 - 2.9e-13 49.2 24.1 3.7e-13 48.9 16.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Paramecium_SA PF01508.11 ESL05220.1 - 4.7 7.4 14.5 1.2e+02 3.0 10.0 2.4 1 1 0 1 1 1 0 Paramecium surface antigen domain DUF3522 PF12036.3 ESL05220.1 - 4.8 6.9 13.5 16 5.2 4.1 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) Peptidase_M8 PF01457.11 ESL05221.1 - 4.3e-93 312.4 0.0 5.1e-93 312.1 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin DUF4131 PF13567.1 ESL05221.1 - 0.00035 20.0 0.3 0.001 18.5 0.2 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4131) Astacin PF01400.19 ESL05221.1 - 0.21 10.9 0.3 0.37 10.1 0.2 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) HMG_box PF00505.14 ESL05222.1 - 4.7e-38 129.2 10.8 5.9e-20 71.3 0.6 2.6 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESL05222.1 - 1e-24 86.6 11.9 3.6e-13 49.6 3.7 2.6 2 0 0 2 2 2 2 HMG-box domain DEK_C PF08766.6 ESL05222.1 - 1.1e-05 25.0 2.4 1.5e-05 24.6 0.2 2.2 2 0 0 2 2 2 1 DEK C terminal domain DUF1074 PF06382.6 ESL05222.1 - 0.019 14.9 8.2 0.026 14.5 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1074) YABBY PF04690.8 ESL05222.1 - 0.037 14.2 0.3 0.037 14.2 0.2 2.0 1 1 1 2 2 2 0 YABBY protein Securin PF04856.8 ESL05222.1 - 0.046 13.4 2.5 0.087 12.5 1.7 1.5 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor CKAP2_C PF15297.1 ESL05222.1 - 0.67 8.7 9.4 0.057 12.2 2.4 2.0 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus HMG_box_5 PF14887.1 ESL05222.1 - 1.3 8.9 13.8 0.83 9.4 1.0 2.9 3 0 0 3 3 3 0 HMG (high mobility group) box 5 Ribosomal_L18_c PF14204.1 ESL05222.1 - 8.4 7.0 11.1 0.76 10.3 0.6 3.4 3 1 0 3 3 3 0 Ribosomal L18 C-terminal region HSP70 PF00012.15 ESL05223.1 - 1.6e-268 891.6 6.9 1.8e-268 891.4 4.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL05223.1 - 3.8e-14 52.0 0.2 5.9e-13 48.1 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 ESL05223.1 - 0.00025 20.7 0.1 0.0019 17.8 0.0 2.3 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Asp_decarbox PF02261.11 ESL05223.1 - 0.07 12.7 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Aspartate decarboxylase SRI PF08236.6 ESL05223.1 - 0.094 12.6 0.7 0.23 11.4 0.1 1.9 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain Glycos_transf_2 PF00535.21 ESL05224.1 - 1.3e-05 24.9 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESL05224.1 - 0.00076 19.3 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESL05224.1 - 0.0015 17.7 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESL05224.1 - 0.0026 17.4 0.1 0.0065 16.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 UIM PF02809.15 ESL05224.1 - 4.4 7.1 5.3 2.2 8.0 0.9 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Peptidase_M8 PF01457.11 ESL05225.1 - 1.8e-102 343.3 4.1 1.2e-101 340.6 2.9 1.8 1 1 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESL05225.1 - 0.019 14.9 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF3810 PF12725.2 ESL05225.1 - 0.12 11.2 0.2 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Peripla_BP_6 PF13458.1 ESL05226.1 - 0.00096 18.5 0.4 0.0012 18.2 0.3 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Aminotran_1_2 PF00155.16 ESL05227.1 - 8.4e-74 248.6 0.0 9.7e-74 248.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 ESL05227.1 - 0.012 14.6 0.0 4.1 6.3 0.0 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 ESL05227.1 - 0.089 11.9 0.0 0.21 10.6 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase DGF-1_5 PF11038.3 ESL05228.1 - 1.3e-147 490.4 16.3 2.1e-147 489.7 11.3 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05228.1 - 2.6e-20 72.0 0.3 9.8e-20 70.2 0.2 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESL05228.1 - 9e-14 51.6 14.6 2e-13 50.5 10.1 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF4227 PF14004.1 ESL05228.1 - 0.015 15.0 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) TPR_11 PF13414.1 ESL05230.1 - 5.1e-08 32.4 0.1 0.0022 17.5 0.0 2.6 1 1 2 3 3 3 2 TPR repeat TPR_2 PF07719.12 ESL05230.1 - 0.012 15.4 0.7 0.73 9.8 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.2 ESL05230.1 - 0.017 14.9 0.1 0.097 12.4 0.0 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_9 PF13371.1 ESL05230.1 - 0.067 13.0 0.4 1.3 8.9 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL05230.1 - 0.11 12.3 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL05230.1 - 0.15 11.7 0.4 6.3 6.5 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat BNR_3 PF13859.1 ESL05231.1 - 3.5e-80 269.3 0.2 9.6e-80 267.9 0.0 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESL05231.1 - 7.1e-12 45.8 1.1 1.8e-11 44.5 0.8 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESL05231.1 - 5.1e-05 22.7 0.5 0.00022 20.6 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain DUF3757 PF12582.3 ESL05231.1 - 0.066 13.3 0.6 0.17 12.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3757) Peripla_BP_6 PF13458.1 ESL05232.1 - 1.3e-14 54.2 2.5 1.6e-14 54.0 1.7 1.1 1 0 0 1 1 1 1 Periplasmic binding protein SEP PF08059.8 ESL05233.1 - 1.2e-05 25.4 0.0 3.6e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 ESL05233.1 - 0.00035 20.5 0.0 0.00083 19.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain Ubiquitin_2 PF14560.1 ESL05233.1 - 0.0016 18.6 0.1 2.4 8.4 0.0 3.7 4 1 0 4 4 4 1 Ubiquitin-like domain Tho2 PF11262.3 ESL05233.1 - 0.72 8.8 3.2 1.1 8.2 2.2 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 CR6_interact PF10147.4 ESL05233.1 - 3.4 6.9 13.7 7.5 5.8 9.5 1.6 1 1 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Aa_trans PF01490.13 ESL05234.1 - 2.6e-34 118.4 20.0 3e-34 118.2 13.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Syndecan PF01034.15 ESL05234.1 - 7.7 6.2 9.3 4.9 6.8 0.2 3.9 2 1 2 4 4 4 0 Syndecan domain BNR_3 PF13859.1 ESL05235.1 - 1.4e-72 244.4 0.0 6.8e-72 242.1 0.0 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESL05235.1 - 4e-12 46.6 1.2 8.3e-12 45.6 0.8 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESL05235.1 - 0.00043 19.6 0.1 0.0024 17.2 0.0 2.0 2 0 0 2 2 2 1 BNR repeat-like domain EB_dh PF09459.5 ESL05235.1 - 0.062 12.7 0.1 0.099 12.0 0.1 1.4 1 0 0 1 1 1 0 Ethylbenzene dehydrogenase DUF3757 PF12582.3 ESL05235.1 - 0.083 13.0 0.1 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3757) DGF-1_5 PF11038.3 ESL05236.1 - 5e-147 488.4 16.3 5e-147 488.4 11.3 2.5 2 1 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05236.1 - 1.6e-21 75.9 0.2 5.6e-21 74.2 0.1 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESL05236.1 - 1e-07 32.2 27.3 1e-06 28.9 19.0 2.4 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF4227 PF14004.1 ESL05236.1 - 0.029 14.1 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) Peptidase_M8 PF01457.11 ESL05237.1 - 3.9e-123 411.5 0.1 4.8e-123 411.2 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESL05237.1 - 0.0063 16.2 0.0 0.009 15.7 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.1 ESL05237.1 - 0.012 16.1 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.3 ESL05237.1 - 0.039 13.2 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.19 ESL05237.1 - 0.075 12.4 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.1 ESL05237.1 - 0.096 12.2 0.0 0.63 9.5 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF4457 PF14652.1 ESL05237.1 - 0.27 10.1 0.0 0.42 9.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) DGF-1_5 PF11038.3 ESL05238.1 - 5e-147 488.4 16.3 5e-147 488.4 11.3 2.6 2 1 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05238.1 - 2.8e-22 78.4 0.2 9.4e-22 76.7 0.2 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESL05238.1 - 2.3e-13 50.3 13.5 5.4e-13 49.1 9.3 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF4227 PF14004.1 ESL05238.1 - 0.029 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) Pkinase PF00069.20 ESL05239.1 - 1.8e-39 135.4 0.0 4.4e-25 88.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05239.1 - 2.8e-18 65.9 0.1 2.7e-09 36.4 0.1 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESL05239.1 - 0.00012 21.9 0.0 0.0014 18.3 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL05239.1 - 0.00041 19.4 0.0 0.00095 18.2 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL05239.1 - 0.00053 19.0 0.2 0.017 14.0 0.0 2.5 3 0 0 3 3 3 1 Kinase-like EcKinase PF02958.15 ESL05239.1 - 0.0045 16.1 0.0 0.0073 15.4 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Pilt PF15453.1 ESL05239.1 - 0.016 14.9 0.6 0.022 14.4 0.4 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions YrbL-PhoP_reg PF10707.4 ESL05239.1 - 0.029 13.6 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL NCD1 PF04904.8 ESL05239.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) Ribosomal_L44 PF00935.14 ESL05240.1 - 1.3e-31 108.3 8.0 2e-31 107.8 5.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 RNHCP PF12647.2 ESL05240.1 - 0.17 11.6 2.8 0.35 10.7 0.1 2.0 1 1 1 2 2 2 0 RNHCP domain PseudoU_synth_1 PF01416.15 ESL05241.1 - 1.5e-19 70.3 0.0 4.3e-10 39.9 0.0 2.9 2 1 0 2 2 2 2 tRNA pseudouridine synthase Dynein_heavy PF03028.10 ESL05242.1 - 8.7e-172 572.7 0.8 1.5e-171 572.0 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 ESL05242.1 - 1.3e-71 240.6 0.0 3.2e-71 239.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESL05242.1 - 5.4e-46 156.2 0.6 1.3e-44 151.7 0.4 2.5 1 1 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 ESL05242.1 - 7.5e-44 149.8 0.0 1.2e-43 149.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 ESL05242.1 - 4.2e-37 127.6 6.5 4.2e-37 127.6 4.5 1.5 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESL05242.1 - 4.5e-13 49.1 0.0 0.00053 19.7 0.0 4.5 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL05242.1 - 9.4e-06 25.7 4.1 0.026 14.5 0.0 5.1 4 1 1 5 5 5 1 AAA ATPase domain AAA_22 PF13401.1 ESL05242.1 - 0.00079 19.5 0.0 0.061 13.4 0.0 3.7 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.21 ESL05242.1 - 0.032 13.7 0.0 0.21 11.0 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_14 PF13173.1 ESL05242.1 - 0.032 14.1 0.0 0.36 10.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 ESL05242.1 - 0.66 9.7 10.3 0.63 9.8 0.9 3.6 5 0 0 5 5 5 0 Domain of unknown function DUF87 TMA7 PF09072.5 ESL05243.1 - 1e-19 70.7 14.2 1.2e-19 70.4 9.9 1.1 1 0 0 1 1 1 1 Translation machinery associated TMA7 PKK PF12474.3 ESL05243.1 - 0.019 14.6 3.6 0.021 14.5 2.5 1.0 1 0 0 1 1 1 0 Polo kinase kinase AMP-binding PF00501.23 ESL05244.1 - 1.6e-77 260.6 0.0 2e-77 260.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme STT3 PF02516.9 ESL05245.1 - 6.9e-49 167.1 32.0 2.9e-46 158.4 20.4 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Beta_helix PF13229.1 ESL05246.1 - 4.9e-10 39.3 1.7 0.0017 18.1 0.2 4.5 3 1 0 3 3 3 2 Right handed beta helix region ABC2_membrane PF01061.19 ESL05247.1 - 1.5e-36 125.5 23.1 1.6e-36 125.4 15.2 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESL05247.1 - 6.9e-19 68.5 0.0 1e-18 67.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL05247.1 - 0.00024 20.4 0.0 0.0015 17.7 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESL05247.1 - 0.00076 19.8 0.0 0.0012 19.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 ESL05247.1 - 0.00081 19.4 0.0 1.2 8.9 0.1 2.2 1 1 0 2 2 2 2 AAA domain AAA_15 PF13175.1 ESL05247.1 - 0.00084 18.4 0.0 0.3 10.0 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 ESL05247.1 - 0.0016 17.9 0.5 0.0032 16.9 0.4 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.1 ESL05247.1 - 0.0088 15.7 0.6 0.036 13.7 0.1 2.2 3 0 0 3 3 3 1 Part of AAA domain DUF258 PF03193.11 ESL05247.1 - 0.015 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESL05247.1 - 0.015 16.1 0.0 0.03 15.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESL05247.1 - 0.018 15.1 0.1 0.043 13.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL05247.1 - 0.023 14.0 0.0 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 ESL05247.1 - 0.042 13.4 0.4 0.075 12.5 0.3 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESL05247.1 - 0.066 12.9 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 NTPase NB-ARC PF00931.17 ESL05247.1 - 0.093 11.5 0.1 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.1 ESL05247.1 - 0.096 12.6 0.1 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.2 ESL05247.1 - 0.097 12.0 0.3 0.18 11.1 0.2 1.4 1 0 0 1 1 1 0 AAA-like domain NACHT PF05729.7 ESL05247.1 - 0.13 11.9 0.1 0.24 11.0 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 ESL05247.1 - 0.14 12.3 0.3 0.55 10.4 0.2 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.13 ESL05247.1 - 0.15 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.18 ESL05247.1 - 0.15 12.0 0.1 0.29 11.1 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase TIP49 PF06068.8 ESL05247.1 - 0.3 9.7 0.1 0.46 9.1 0.1 1.1 1 0 0 1 1 1 0 TIP49 C-terminus DUF87 PF01935.12 ESL05247.1 - 0.32 10.7 0.6 0.57 9.9 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 Hydrolase PF00702.21 ESL05249.1 - 1.8e-24 87.3 0.0 9.7e-24 84.9 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL05249.1 - 1.5e-14 54.6 0.0 2.8e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ESL05249.1 - 2.5e-12 46.3 8.2 1.6e-11 43.7 2.4 3.3 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.7 ESL05249.1 - 1.2e-05 25.0 0.1 0.00068 19.2 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ion_trans_2 PF07885.11 ESL05249.1 - 0.052 13.2 0.3 0.052 13.2 0.2 2.5 2 1 0 2 2 2 0 Ion channel Aa_trans PF01490.13 ESL05250.1 - 3.2e-38 131.2 26.9 4.1e-38 130.9 18.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Galactosyl_T PF01762.16 ESL05251.1 - 8.4e-09 35.3 0.0 0.00045 19.8 0.0 3.3 3 1 1 4 4 4 3 Galactosyltransferase RHSP PF07999.6 ESL05252.1 - 2e-31 109.0 0.0 2.8e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3184 PF11380.3 ESL05253.1 - 4.5e-262 871.0 18.6 4.8e-121 404.9 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3184) BCL_N PF04714.8 ESL05253.1 - 0.19 11.3 1.2 0.41 10.2 0.1 2.1 2 0 0 2 2 2 0 BCL7, N-terminal conserver region Galactosyl_T PF01762.16 ESL05254.1 - 3.3e-09 36.6 0.0 0.0015 18.1 0.0 3.7 4 0 0 4 4 4 2 Galactosyltransferase BNR_3 PF13859.1 ESL05255.1 - 3.8e-59 200.2 0.0 4.7e-59 199.9 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05255.1 - 7.8e-09 35.2 0.0 1.8e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESL05255.1 - 3.2e-05 23.1 0.4 0.44 10.5 0.0 2.8 2 0 0 2 2 2 2 BNR/Asp-box repeat Kelch_6 PF13964.1 ESL05255.1 - 0.12 12.5 0.6 2.6 8.3 0.0 3.1 3 0 0 3 3 3 0 Kelch motif ubiquitin PF00240.18 ESL05256.1 - 2.8e-54 180.4 1.7 4.4e-33 112.5 0.2 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESL05256.1 - 2.1e-32 110.6 2.0 5.9e-20 70.7 0.2 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESL05256.1 - 8.4e-11 41.9 0.2 0.00015 21.9 0.0 2.8 2 1 0 2 2 2 2 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ESL05256.1 - 5.1e-07 29.5 0.0 0.0029 17.3 0.0 2.0 2 0 0 2 2 2 2 Telomere stability and silencing DUF2407 PF10302.4 ESL05256.1 - 0.0014 18.7 0.0 0.15 12.2 0.0 2.1 1 1 1 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESL05256.1 - 0.0037 17.1 0.2 0.065 13.1 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like FlgD_ig PF13860.1 ESL05256.1 - 0.0046 16.6 0.3 3.6 7.3 0.0 2.2 2 0 0 2 2 2 2 FlgD Ig-like domain Plexin_cytopl PF08337.7 ESL05256.1 - 0.014 13.7 3.6 1.2 7.3 0.3 2.8 1 1 2 3 3 3 0 Plexin cytoplasmic RasGAP domain CTDII PF01556.13 ESL05256.1 - 0.019 14.8 1.3 2.3 8.1 0.1 2.2 1 1 1 2 2 2 0 DnaJ C terminal domain TUG-UBL1 PF11470.3 ESL05256.1 - 0.022 14.6 0.0 2.5 8.0 0.0 2.2 2 0 0 2 2 2 0 GLUT4 regulating protein TUG USP7_C2 PF14533.1 ESL05256.1 - 0.066 12.6 0.1 8.8 5.6 0.0 2.0 1 1 0 2 2 2 0 Ubiquitin-specific protease C-terminal DUF2870 PF11069.3 ESL05256.1 - 0.075 13.0 0.1 0.4 10.7 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2870) Big_3_3 PF13750.1 ESL05256.1 - 0.13 11.7 0.0 14 5.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) DUF3781 PF12636.2 ESL05256.1 - 0.14 12.1 0.2 22 5.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3781) PHO4 PF01384.15 ESL05257.1 - 1.1e-104 349.6 24.9 1.4e-104 349.2 17.3 1.1 1 0 0 1 1 1 1 Phosphate transporter family Myco_arth_vir_N PF09610.5 ESL05257.1 - 0.086 12.8 0.4 0.68 9.9 0.0 2.8 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimer_Tnp_hAT PF05699.9 ESL05257.1 - 0.11 12.0 1.4 0.87 9.2 0.0 2.3 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Peptidase_M14 PF00246.19 ESL05258.1 - 2.6e-26 92.8 0.0 4.6e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESL05258.1 - 0.017 14.0 0.0 0.028 13.3 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family DUF1510 PF07423.6 ESL05258.1 - 6 6.1 11.1 13 5.0 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4217 PF13959.1 ESL05259.1 - 0.0012 18.2 0.1 0.0024 17.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) DUF2249 PF10006.4 ESL05259.1 - 0.27 10.8 2.0 17 5.1 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2249) FMN_dh PF01070.13 ESL05260.1 - 1.2e-28 99.9 0.2 3.7e-21 75.3 0.3 2.0 2 0 0 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.20 ESL05260.1 - 8.3e-08 31.5 0.4 1e-05 24.6 0.1 2.8 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 ESL05260.1 - 0.0042 16.0 1.0 0.0075 15.2 0.7 1.4 1 1 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.16 ESL05260.1 - 0.0089 15.3 0.0 0.021 14.1 0.0 1.6 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.10 ESL05260.1 - 0.032 13.3 0.1 0.051 12.7 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase PDEase_I PF00233.14 ESL05261.1 - 9.1e-12 45.2 0.1 2.8e-11 43.6 0.0 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase IncA PF04156.9 ESL05261.1 - 0.0014 18.3 2.0 0.0014 18.3 1.4 3.3 3 0 0 3 3 3 2 IncA protein DUF948 PF06103.6 ESL05261.1 - 0.043 13.6 0.8 0.42 10.4 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.10 ESL05261.1 - 0.34 10.6 2.1 1.2 8.8 1.1 2.1 2 0 0 2 2 2 0 Sec34-like family DUF4446 PF14584.1 ESL05261.1 - 0.95 9.2 3.8 7.6 6.3 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) TMF_DNA_bd PF12329.3 ESL05261.1 - 1.3 8.8 22.2 1.2 8.9 6.9 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding MFS_1 PF07690.11 ESL05262.1 - 6e-19 67.9 31.5 5.5e-16 58.2 15.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05262.1 - 9.3e-13 47.9 20.1 2.5e-11 43.3 13.9 2.5 1 1 0 1 1 1 1 Nodulin-like Ribosomal_S9 PF00380.14 ESL05263.1 - 1.6e-28 99.4 2.3 2.7e-28 98.6 1.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CBM-like PF14683.1 ESL05263.1 - 0.13 11.8 0.9 0.35 10.4 0.2 1.8 1 1 1 2 2 2 0 Polysaccharide lyase family 4, domain III RRM_1 PF00076.17 ESL05264.1 - 4e-19 68.0 0.0 2.5e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL05264.1 - 2.7e-15 56.0 0.0 1.7e-09 37.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL05264.1 - 8.6e-11 41.5 0.0 0.00031 20.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 ESL05264.1 - 0.079 12.9 0.0 0.44 10.5 0.0 2.0 2 0 0 2 2 2 0 RNA binding domain Nup35_RRM_2 PF14605.1 ESL05264.1 - 0.09 12.5 0.1 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PALP PF00291.20 ESL05265.1 - 2.7e-40 138.5 0.0 3.2e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Bmp PF02608.9 ESL05265.1 - 0.04 12.6 0.0 3.9 6.1 0.0 2.1 2 0 0 2 2 2 0 Basic membrane protein Laminin_G_3 PF13385.1 ESL05266.1 - 2.3e-13 50.6 0.5 4.6e-13 49.6 0.3 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESL05266.1 - 0.00085 19.1 1.0 0.00085 19.1 0.7 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESL05266.1 - 0.0023 17.0 0.1 0.0053 15.8 0.0 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Glycos_transf_2 PF00535.21 ESL05267.1 - 1.3e-05 24.9 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESL05267.1 - 0.00076 19.3 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESL05267.1 - 0.0015 17.7 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESL05267.1 - 0.0026 17.4 0.1 0.0065 16.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 UIM PF02809.15 ESL05267.1 - 4.4 7.1 5.3 2.2 8.0 0.9 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif SYS1 PF09801.4 ESL05268.1 - 1.6e-30 105.9 4.3 2.1e-30 105.6 3.0 1.2 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network GP38 PF05268.6 ESL05268.1 - 0.43 9.9 13.8 0.64 9.4 9.6 1.2 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 Sugar_tr PF00083.19 ESL05269.1 - 3.1e-103 345.7 36.5 3.2e-102 342.4 25.3 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL05269.1 - 3e-18 65.6 26.3 7.3e-15 54.5 18.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Syndecan PF01034.15 ESL05269.1 - 0.43 10.2 4.0 0.44 10.2 0.0 3.1 2 0 0 2 2 2 0 Syndecan domain Paramecium_SA PF01508.11 ESL05269.1 - 7.7 6.8 14.5 30 4.9 8.4 2.4 1 1 1 2 2 2 0 Paramecium surface antigen domain Ribosomal_L7Ae PF01248.21 ESL05270.1 - 3.6e-21 74.4 1.6 5.7e-21 73.8 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 ESL05270.1 - 8.4e-05 22.4 0.1 0.00014 21.7 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 PAP_assoc PF03828.14 ESL05271.1 - 2.1e-10 40.3 0.0 6.1e-10 38.8 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESL05271.1 - 6.6e-07 29.5 0.0 1.3e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain RRM_1 PF00076.17 ESL05272.1 - 1.9e-22 78.6 0.0 2.6e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL05272.1 - 5.7e-16 58.2 0.0 9.8e-16 57.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL05272.1 - 2.1e-13 49.9 0.0 3.2e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM209 PF15206.1 ESL05272.1 - 0.12 12.2 0.2 14 5.4 0.4 2.2 2 0 0 2 2 2 0 FAM209 family PAT1 PF09770.4 ESL05272.1 - 0.18 9.9 15.6 0.21 9.7 10.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BNR_3 PF13859.1 ESL05273.1 - 2.2e-74 250.3 0.5 3.3e-74 249.7 0.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05273.1 - 2.9e-18 66.1 0.3 1.1e-17 64.2 0.2 1.9 1 1 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESL05273.1 - 1.6e-14 54.4 0.1 1.6e-14 54.4 0.1 2.4 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESL05273.1 - 1.1e-06 27.5 7.4 0.35 10.8 0.2 4.7 3 0 0 3 3 3 3 BNR/Asp-box repeat Prominin PF05478.6 ESL05274.1 - 0.03 11.8 4.1 0.038 11.5 2.9 1.1 1 0 0 1 1 1 0 Prominin DUF3481 PF11980.3 ESL05274.1 - 5.3 6.9 6.4 4.6 7.1 2.4 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3481) RNase_T PF00929.19 ESL05275.1 - 8.4e-24 84.7 0.0 1.3e-23 84.1 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Galactosyl_T PF01762.16 ESL05276.1 - 1e-08 35.0 0.3 0.0011 18.5 0.1 3.4 3 1 0 3 3 3 2 Galactosyltransferase EF-hand_1 PF00036.27 ESL05277.1 - 4.7e-24 81.8 2.4 2.6e-07 29.4 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESL05277.1 - 1.7e-21 76.1 7.3 3.1e-11 43.2 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL05277.1 - 5.7e-20 69.3 4.9 0.00017 21.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 ESL05277.1 - 9.5e-18 62.6 7.4 0.00012 21.2 0.0 4.6 5 0 0 5 5 4 4 EF hand EF-hand_8 PF13833.1 ESL05277.1 - 2e-15 56.1 7.3 7.7e-06 25.4 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain pair zf-C3HC4_3 PF13920.1 ESL05277.1 - 4.7e-09 35.7 7.3 4.7e-09 35.7 5.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL05277.1 - 9.6e-08 31.7 8.0 2.5e-07 30.3 5.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL05277.1 - 1.2e-07 31.6 9.3 1.2e-07 31.6 6.5 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL05277.1 - 4e-07 29.5 5.0 4e-07 29.5 3.5 2.1 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 ESL05277.1 - 2.1e-06 27.4 6.3 2.1e-06 27.4 4.4 1.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 ESL05277.1 - 2.3e-06 27.3 6.8 2.5e-06 27.2 1.5 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 ESL05277.1 - 6e-06 25.8 9.3 6e-06 25.8 6.4 1.9 2 0 0 2 2 2 1 zinc-RING finger domain SPARC_Ca_bdg PF10591.4 ESL05277.1 - 7.8e-06 25.8 0.0 0.011 15.7 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region zf-RING_UBOX PF13445.1 ESL05277.1 - 7.7e-05 22.3 9.5 0.0019 17.8 1.3 2.4 2 0 0 2 2 2 2 RING-type zinc-finger zf-Nse PF11789.3 ESL05277.1 - 0.066 12.7 3.4 0.21 11.1 2.4 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.1 ESL05277.1 - 0.11 12.0 5.3 0.24 10.9 3.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-MIZ PF02891.15 ESL05277.1 - 0.14 11.7 10.6 0.26 10.8 5.7 2.6 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger Rtf2 PF04641.7 ESL05277.1 - 0.14 11.3 1.4 0.21 10.7 1.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_4 PF14570.1 ESL05277.1 - 0.72 9.4 7.5 2.3 7.8 5.2 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.2 ESL05277.1 - 1.7 8.7 8.9 4.1 7.5 5.6 2.1 1 1 1 2 2 2 0 RING-H2 zinc finger IBR PF01485.16 ESL05277.1 - 4.2 7.3 11.3 13 5.7 0.2 3.2 2 1 1 3 3 3 0 IBR domain OrfB_Zn_ribbon PF07282.6 ESL05277.1 - 8.4 6.1 7.1 9.1 6.0 1.1 3.0 2 1 1 3 3 3 0 Putative transposase DNA-binding domain DGF-1_5 PF11038.3 ESL05280.1 - 9.5e-139 461.2 16.9 1.3e-138 460.8 11.7 1.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05280.1 - 8.4e-22 76.8 0.7 1.7e-21 75.8 0.1 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SHR3_chaperone PF08229.6 ESL05280.1 - 0.0011 17.9 0.4 0.0022 16.9 0.3 1.4 1 0 0 1 1 1 1 ER membrane protein SH3 DUF4227 PF14004.1 ESL05280.1 - 0.072 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) Herpes_LMP1 PF05297.6 ESL05280.1 - 3.4 6.4 12.2 0.67 8.8 5.2 1.8 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Galactosyl_T PF01762.16 ESL05281.1 - 2.3e-05 24.0 0.8 0.00047 19.8 0.1 2.6 2 1 0 2 2 2 1 Galactosyltransferase Aa_trans PF01490.13 ESL05282.1 - 5.5e-46 156.8 31.5 6.4e-46 156.6 21.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL05282.1 - 1e-12 47.5 12.2 1e-12 47.5 8.5 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Fumarate_red_D PF02313.12 ESL05282.1 - 6.6 6.6 11.9 3.3 7.6 0.7 3.2 3 0 0 3 3 3 0 Fumarate reductase subunit D Peptidase_S9 PF00326.16 ESL05283.1 - 4e-35 120.9 0.0 6.7e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.16 ESL05283.1 - 3e-17 62.2 0.0 4e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_5 PF12695.2 ESL05283.1 - 3.1e-06 27.0 0.0 6.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL05283.1 - 0.002 18.0 0.0 0.0037 17.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family GRAM PF02893.15 ESL05283.1 - 0.0031 17.0 0.0 0.16 11.5 0.0 2.6 2 0 0 2 2 2 1 GRAM domain Esterase PF00756.15 ESL05283.1 - 0.013 14.9 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Peptidase_S15 PF02129.13 ESL05283.1 - 0.034 13.5 0.0 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.13 ESL05283.1 - 0.074 12.3 0.1 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF3141 PF11339.3 ESL05283.1 - 0.11 10.7 0.1 0.17 10.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) DUF2007 PF09413.5 ESL05283.1 - 0.17 11.7 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2007) zf-CCCH PF00642.19 ESL05285.1 - 0.0046 16.6 3.2 0.0046 16.6 2.3 3.8 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nucleoside_tran PF01733.13 ESL05286.1 - 1.1e-30 106.9 0.8 1.1e-30 106.9 0.6 2.0 2 1 0 2 2 2 1 Nucleoside transporter Vma12 PF11712.3 ESL05286.1 - 0.14 11.8 2.6 2.4 7.8 0.2 2.8 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Peptidase_M8 PF01457.11 ESL05287.1 - 5.1e-126 421.0 0.0 6.7e-126 420.6 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin BRE1 PF08647.6 ESL05288.1 - 2.2e-19 69.2 15.7 2.2e-19 69.2 10.9 7.7 6 2 2 9 9 9 4 BRE1 E3 ubiquitin ligase TMF_TATA_bd PF12325.3 ESL05288.1 - 4.3e-05 23.2 16.8 4.3e-05 23.2 11.6 7.7 2 2 5 8 8 8 4 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESL05288.1 - 0.0078 15.8 22.8 0.0078 15.8 15.8 5.9 1 1 3 5 5 5 2 IncA protein gpW PF02831.10 ESL05288.1 - 0.23 11.0 3.2 0.41 10.2 0.1 3.1 3 0 0 3 3 3 0 gpW Reo_sigmaC PF04582.7 ESL05288.1 - 0.29 10.2 28.5 2.2 7.3 0.0 4.9 2 2 2 4 4 4 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 ESL05288.1 - 2.9 6.2 80.2 0.015 13.7 13.8 4.4 1 1 2 3 3 3 0 AAA domain MtrB PF05440.7 ESL05288.1 - 8.3 6.5 14.1 2.9 7.9 0.1 5.2 6 0 0 6 6 6 0 Tetrahydromethanopterin S-methyltransferase subunit B Peptidase_C2 PF00648.16 ESL05289.1 - 2.2e-24 86.0 0.0 3.1e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 ESL05289.1 - 2.8e-13 49.7 0.0 5.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III PC_rep PF01851.17 ESL05290.1 - 2.3e-27 93.6 13.8 2.1e-06 27.6 0.0 8.0 7 0 0 7 7 7 5 Proteasome/cyclosome repeat HEAT_2 PF13646.1 ESL05290.1 - 0.084 13.1 4.0 3.6 7.9 0.8 3.7 2 2 2 4 4 4 0 HEAT repeats TPR_5 PF12688.2 ESL05290.1 - 0.1 12.6 1.4 0.78 9.7 0.1 2.8 2 1 0 2 2 2 0 Tetratrico peptide repeat IFRD PF05004.8 ESL05290.1 - 0.41 9.6 2.8 0.56 9.2 0.3 2.3 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) TPR_11 PF13414.1 ESL05291.1 - 2.7e-13 49.3 12.9 2.7e-09 36.5 0.1 4.9 4 1 2 6 6 6 3 TPR repeat TPR_2 PF07719.12 ESL05291.1 - 7.9e-10 37.8 8.5 0.017 14.9 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESL05291.1 - 7.3e-09 35.1 1.8 0.00017 21.4 0.2 4.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL05291.1 - 1.3e-08 34.0 2.2 0.29 10.8 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL05291.1 - 1e-06 28.7 16.7 0.19 12.4 0.0 6.8 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESL05291.1 - 1.9e-05 24.1 0.5 8 6.5 0.0 5.7 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL05291.1 - 0.00015 22.0 0.8 0.31 11.4 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL05291.1 - 0.00041 20.9 6.6 0.044 14.4 0.1 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESL05291.1 - 0.00096 18.2 3.3 0.011 14.8 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL05291.1 - 0.0033 17.3 12.8 0.7 9.8 0.0 5.4 5 1 0 5 5 5 2 Tetratricopeptide repeat OGG_N PF07934.7 ESL05291.1 - 0.021 14.7 0.5 2.8 7.9 0.1 3.6 3 1 0 3 3 3 0 8-oxoguanine DNA glycosylase, N-terminal domain Clathrin PF00637.15 ESL05291.1 - 0.066 12.8 1.4 0.24 11.0 0.2 2.4 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_7 PF13176.1 ESL05291.1 - 1.4 8.9 9.6 15 5.7 0.0 5.0 5 1 0 5 5 4 0 Tetratricopeptide repeat Abhydrolase_6 PF12697.2 ESL05292.1 - 1.7e-26 93.4 2.1 2.5e-26 93.0 1.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL05292.1 - 1.2e-19 70.8 0.0 3.2e-18 66.1 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESL05292.1 - 7.6e-13 48.4 0.0 1.2e-05 25.1 0.0 2.3 2 1 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 ESL05292.1 - 5.7e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Ndr PF03096.9 ESL05292.1 - 0.00071 18.1 0.0 0.0063 15.0 0.0 2.1 2 1 0 2 2 2 1 Ndr family Esterase_phd PF10503.4 ESL05292.1 - 0.0025 17.1 0.2 0.4 9.9 0.1 2.3 2 0 0 2 2 2 2 Esterase PHB depolymerase Hydrolase_4 PF12146.3 ESL05292.1 - 0.0032 17.2 0.0 0.0082 15.9 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 ESL05292.1 - 0.004 16.4 0.0 0.089 12.0 0.0 2.3 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF2048 PF09752.4 ESL05292.1 - 0.017 13.9 0.3 0.057 12.2 0.2 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Esterase PF00756.15 ESL05292.1 - 0.018 14.5 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_2 PF02230.11 ESL05292.1 - 0.018 14.4 0.0 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Histone PF00125.19 ESL05294.1 - 1.7e-23 82.5 1.5 1.9e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL05294.1 - 7.1e-06 25.9 0.7 9.9e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESL05294.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated CENP-S PF15630.1 ESL05294.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore component CENP-S YihI PF04220.7 ESL05294.1 - 0.52 9.6 2.3 0.69 9.2 1.6 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) FH2 PF02181.18 ESL05295.1 - 4e-51 174.0 1.6 6.2e-51 173.4 1.1 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain RsgI_N PF12791.2 ESL05295.1 - 0.18 11.4 0.2 0.34 10.6 0.1 1.4 1 0 0 1 1 1 0 Anti-sigma factor N-terminus PIGA PF08288.7 ESL05296.1 - 1.1e-36 124.9 0.1 2.2e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 ESL05296.1 - 9.7e-27 93.4 0.0 1.4e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 ESL05296.1 - 7.3e-18 64.9 1.4 7.9e-17 61.5 1.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 ESL05296.1 - 4.6e-17 62.6 0.3 3.4e-16 59.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 ESL05296.1 - 5.8e-11 42.6 0.0 1.4e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 ESL05296.1 - 8.4e-05 22.4 0.0 0.00022 21.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 ESL05296.1 - 0.034 14.4 0.0 0.085 13.1 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 Actin PF00022.14 ESL05297.1 - 8.3e-148 492.0 0.0 9.7e-148 491.7 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ESL05297.1 - 0.012 16.0 0.1 0.13 12.6 0.0 2.2 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ribosomal_S3Ae PF01015.13 ESL05298.1 - 4.2e-59 199.1 3.8 5.4e-59 198.7 2.6 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family 7tm_7 PF08395.7 ESL05298.1 - 0.0013 17.8 0.2 0.0027 16.8 0.2 1.5 1 0 0 1 1 1 1 7tm Chemosensory receptor Sre PF03125.13 ESL05298.1 - 0.015 14.2 0.4 0.024 13.5 0.3 1.2 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor Frag1 PF10277.4 ESL05298.1 - 0.072 12.5 5.6 0.12 11.8 3.9 1.3 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family Anticodon_1 PF08264.8 ESL05299.1 - 8.3e-37 126.2 0.0 1.2e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1 PF00133.17 ESL05299.1 - 1e-34 119.5 0.0 1.7e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESL05299.1 - 0.013 14.1 0.0 0.037 12.6 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (M) tRNA-synt_1b PF00579.20 ESL05299.1 - 0.033 13.2 0.0 0.07 12.2 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.13 ESL05299.1 - 0.065 11.9 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (K) TRAM_LAG1_CLN8 PF03798.11 ESL05299.1 - 0.18 11.3 0.1 0.18 11.3 0.0 2.2 3 0 0 3 3 3 0 TLC domain DGF-1_5 PF11038.3 ESL05300.1 - 1.3e-147 490.3 16.3 2.1e-147 489.7 11.3 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05300.1 - 8.6e-22 76.8 0.2 3e-21 75.0 0.1 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESL05300.1 - 1.7e-09 37.9 32.3 8.3e-07 29.3 22.4 2.6 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF4227 PF14004.1 ESL05300.1 - 0.015 15.0 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) START PF01852.14 ESL05301.1 - 8.1e-07 28.5 0.0 1.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 START domain Aa_trans PF01490.13 ESL05302.1 - 1.3e-50 172.0 32.3 1.5e-50 171.8 22.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Peptidase_M8 PF01457.11 ESL05304.1 - 1.2e-74 251.6 3.0 1.4e-74 251.3 2.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Galactosyl_T PF01762.16 ESL05305.1 - 4.8e-09 36.0 0.3 0.0011 18.6 0.1 3.4 3 1 0 3 3 3 2 Galactosyltransferase Galactosyl_T PF01762.16 ESL05307.1 - 0.0019 17.8 0.0 0.47 10.0 0.0 3.0 3 0 0 3 3 3 2 Galactosyltransferase Peptidase_M8 PF01457.11 ESL05308.1 - 4.5e-135 450.9 0.0 5e-135 450.7 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Mito_carr PF00153.22 ESL05310.1 - 3.5e-37 125.9 1.7 9.5e-18 63.7 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein MFS_1 PF07690.11 ESL05311.1 - 2.2e-09 36.4 26.5 2.2e-09 36.4 18.4 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF1673 PF07895.6 ESL05311.1 - 0.57 9.6 5.0 0.43 10.0 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) DnaJ PF00226.26 ESL05312.1 - 0.054 13.2 14.9 0.068 12.9 3.2 3.9 3 1 0 3 3 3 0 DnaJ domain DUF4439 PF14530.1 ESL05312.1 - 0.41 11.1 3.2 2 8.8 2.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4439) Glycos_transf_2 PF00535.21 ESL05313.1 - 1.3e-05 24.9 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESL05313.1 - 0.00074 19.3 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESL05313.1 - 0.0028 17.3 0.1 0.0065 16.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_2 PF10111.4 ESL05313.1 - 0.0043 16.1 0.0 1.3 8.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 UIM PF02809.15 ESL05313.1 - 4.4 7.1 5.3 2.2 8.0 0.9 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif PTS_2-RNA PF01885.11 ESL05314.1 - 1.1e-51 174.7 0.0 1.7e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family RNase_T PF00929.19 ESL05314.1 - 1.4e-19 71.0 0.0 2.1e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Peptidase_M8 PF01457.11 ESL05316.1 - 3.2e-115 385.4 0.0 3.7e-115 385.2 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_3 PF13582.1 ESL05316.1 - 0.037 14.5 0.1 0.074 13.5 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like EF-hand_1 PF00036.27 ESL05317.1 - 5.9e-43 140.9 12.3 2e-10 39.2 0.7 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESL05317.1 - 2.5e-38 130.0 4.2 2.2e-21 75.7 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL05317.1 - 2.2e-33 113.6 11.2 2.3e-16 59.1 0.5 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 ESL05317.1 - 2e-31 105.0 6.7 1.2e-09 37.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 ESL05317.1 - 2.9e-29 99.0 8.0 1.7e-07 30.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 ESL05317.1 - 8.6e-15 54.4 0.1 7.5e-08 32.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 ESL05317.1 - 1.1e-09 37.9 0.9 4.5e-05 23.1 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESL05317.1 - 3e-08 33.6 0.0 0.00049 20.0 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 ESL05317.1 - 1.9e-06 27.3 1.8 0.18 11.4 0.0 3.9 4 1 1 5 5 5 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 ESL05317.1 - 4.8e-06 26.4 1.2 5.9e-05 22.9 0.2 2.3 2 0 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.8 ESL05317.1 - 0.00022 20.9 0.3 0.082 12.6 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.8 ESL05317.1 - 0.00025 20.6 0.1 0.013 15.0 0.1 2.5 1 1 0 1 1 1 1 Caleosin related protein EF-hand_like PF09279.6 ESL05317.1 - 0.00033 20.6 1.2 0.0031 17.5 0.1 2.4 2 1 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like RNA_pol_Rpb4 PF03874.11 ESL05317.1 - 0.0038 17.2 0.5 1.7 8.6 0.1 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb4 DUF1103 PF06513.6 ESL05317.1 - 0.0051 16.2 1.1 0.0059 16.0 0.8 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) MotA_activ PF09114.5 ESL05317.1 - 0.021 14.5 0.1 4.2 7.1 0.0 2.3 2 0 0 2 2 2 0 Transcription factor MotA, activation domain Poly_export PF02563.11 ESL05317.1 - 0.042 13.6 0.2 11 5.8 0.0 3.1 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein LNS2 PF08235.8 ESL05317.1 - 0.045 13.3 0.1 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) Tenui_NCP PF04876.7 ESL05317.1 - 0.064 12.8 0.1 0.95 8.9 0.0 2.1 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein Toprim_2 PF13155.1 ESL05317.1 - 0.065 13.5 0.8 14 6.0 0.3 2.6 1 1 2 3 3 3 0 Toprim-like SpoVIF PF14069.1 ESL05317.1 - 0.077 12.7 0.8 1.6 8.5 0.1 2.6 3 0 0 3 3 3 0 Stage VI sporulation protein F DUF1880 PF08976.6 ESL05317.1 - 0.13 12.3 0.0 0.84 9.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1880) PHO4 PF01384.15 ESL05318.1 - 1.3e-105 352.6 25.6 1.3e-105 352.6 17.7 1.7 2 0 0 2 2 2 1 Phosphate transporter family Myco_arth_vir_N PF09610.5 ESL05318.1 - 0.1 12.5 0.4 0.77 9.7 0.0 2.8 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimer_Tnp_hAT PF05699.9 ESL05318.1 - 0.23 11.0 1.3 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Glyco_hydro_47 PF01532.15 ESL05320.1 - 5.3e-115 384.6 0.0 7e-115 384.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Guanylate_cyc PF00211.15 ESL05321.1 - 2.8e-46 157.2 0.0 5.1e-46 156.3 0.0 1.4 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Podoplanin PF05808.6 ESL05321.1 - 0.056 12.9 1.9 0.15 11.6 1.3 1.7 1 0 0 1 1 1 0 Podoplanin EphA2_TM PF14575.1 ESL05321.1 - 0.16 12.3 0.4 0.42 11.0 0.3 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4006 PF13179.1 ESL05321.1 - 0.34 10.4 1.9 0.78 9.3 1.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF4006) WD40 PF00400.27 ESL05322.1 - 5.2e-12 45.1 10.2 2.5e-05 23.9 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESL05322.1 - 1.3e-06 28.1 2.1 0.0085 15.8 0.1 3.8 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.11 ESL05322.1 - 0.00042 18.7 1.1 0.027 12.7 0.3 2.9 3 0 0 3 3 3 1 Cytochrome D1 heme domain Nup160 PF11715.3 ESL05322.1 - 0.0054 14.9 0.2 0.013 13.6 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Lgl_C PF08596.5 ESL05322.1 - 0.039 12.4 0.2 1.1 7.6 0.0 2.8 2 1 1 3 3 3 0 Lethal giant larvae(Lgl) like, C-terminal Hira PF07569.6 ESL05322.1 - 0.068 12.3 0.0 7 5.8 0.0 2.8 2 1 0 2 2 2 0 TUP1-like enhancer of split PQQ_3 PF13570.1 ESL05322.1 - 0.22 11.8 3.1 1e+02 3.3 0.0 4.9 4 0 0 4 4 4 0 PQQ-like domain Lamp PF01299.12 ESL05322.1 - 1.1 8.3 5.4 3.7 6.6 3.8 1.9 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) PLRV_ORF5 PF01690.12 ESL05322.1 - 4.3 6.3 17.6 7.2 5.6 12.2 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein ELO PF01151.13 ESL05323.1 - 3.9e-82 275.3 19.1 4.5e-82 275.1 13.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family OTCace_N PF02729.16 ESL05324.1 - 4.5e-42 143.0 0.1 8.4e-42 142.1 0.1 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 ESL05324.1 - 8.5e-36 123.2 0.5 3e-35 121.4 0.2 1.8 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain LAT PF15234.1 ESL05326.1 - 0.045 13.2 0.1 0.078 12.4 0.0 1.5 1 0 0 1 1 1 0 Linker for activation of T-cells Rhabdo_glycop PF00974.13 ESL05326.1 - 0.049 11.8 0.1 0.082 11.1 0.1 1.3 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein DUF3481 PF11980.3 ESL05326.1 - 0.16 11.8 0.3 0.55 10.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3481) Prominin PF05478.6 ESL05326.1 - 0.99 6.8 2.5 1.3 6.4 1.7 1.1 1 0 0 1 1 1 0 Prominin Kelch_4 PF13418.1 ESL05327.1 - 1.2e-17 63.3 16.5 0.077 12.7 0.6 8.1 8 0 0 8 8 8 7 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL05327.1 - 4.7e-17 61.6 0.7 0.031 14.4 0.0 7.6 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL05327.1 - 2.7e-16 59.1 8.5 0.0011 18.8 0.1 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESL05327.1 - 3.4e-14 51.9 13.0 0.055 13.2 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 ESL05327.1 - 1.6e-12 46.7 8.9 0.00045 19.7 0.0 6.9 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 ESL05327.1 - 4.2e-12 45.6 9.1 0.2 11.8 0.0 6.9 5 2 1 6 6 6 4 Kelch motif ABC_tran PF00005.22 ESL05328.1 - 4.7e-24 85.2 0.0 9.1e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL05328.1 - 0.00039 19.7 0.0 0.0021 17.3 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ESL05328.1 - 0.0072 17.1 0.0 0.02 15.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL05328.1 - 0.011 15.6 0.0 0.029 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 ESL05328.1 - 0.071 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ESL05328.1 - 0.073 13.0 0.0 0.8 9.6 0.0 2.4 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.1 ESL05328.1 - 0.085 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESL05328.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 ESL05328.1 - 0.12 11.4 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.1 ESL05328.1 - 0.14 12.0 0.0 16 5.3 0.0 2.2 1 1 1 2 2 2 0 AAA domain Mito_carr PF00153.22 ESL05329.1 - 1.4e-43 146.5 0.5 2.4e-18 65.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1126 PF06565.7 ESL05330.1 - 1.5e-21 75.5 5.8 1.1e-10 40.7 0.1 3.4 3 0 0 3 3 3 2 Repeat of unknown function (DUF1126) Pkinase PF00069.20 ESL05331.1 - 1.4e-43 148.9 0.0 1.8e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05331.1 - 4.4e-13 48.8 0.0 1.6e-12 47.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1227 PF06777.6 ESL05332.1 - 1.2e-43 148.2 0.1 2.3e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 ESL05332.1 - 1.1e-39 135.5 0.0 2.5e-39 134.4 0.0 1.6 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 ESL05332.1 - 2.1e-39 135.1 0.0 4.6e-39 134.0 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.24 ESL05332.1 - 0.00015 21.3 0.2 0.075 12.5 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESL05332.1 - 0.00038 20.3 0.2 0.0021 17.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESL05332.1 - 0.0019 17.8 0.1 0.0075 15.9 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain SNF2_N PF00176.18 ESL05332.1 - 0.0074 15.1 1.3 0.14 10.9 0.9 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 ESL05332.1 - 0.029 14.5 0.2 0.22 11.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_11 PF13086.1 ESL05332.1 - 0.055 13.0 0.1 0.13 11.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain F_actin_bind PF08919.5 ESL05332.1 - 0.07 12.8 0.3 0.5 10.1 0.0 2.3 2 0 0 2 2 2 0 F-actin binding Flavi_DEAD PF07652.9 ESL05332.1 - 0.085 12.6 0.3 1.9 8.2 0.0 2.6 2 0 0 2 2 2 0 Flavivirus DEAD domain DivIC PF04977.10 ESL05332.1 - 0.19 11.2 0.8 0.33 10.4 0.1 1.7 2 0 0 2 2 2 0 Septum formation initiator Retrotrans_gag PF03732.12 ESL05333.1 - 8.8 6.4 15.2 3.4 7.8 0.8 3.8 4 1 0 4 4 4 0 Retrotransposon gag protein CAP_GLY PF01302.20 ESL05334.1 - 0.015 15.0 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 CAP-Gly domain BNR_3 PF13859.1 ESL05335.1 - 2.3e-74 250.2 0.5 3.3e-74 249.7 0.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05335.1 - 2.9e-18 66.1 0.3 1.1e-17 64.2 0.2 1.9 1 1 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESL05335.1 - 1.6e-14 54.4 0.1 1.6e-14 54.4 0.1 2.4 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESL05335.1 - 1.1e-06 27.5 7.4 0.35 10.8 0.2 4.7 3 0 0 3 3 3 3 BNR/Asp-box repeat MFS_1 PF07690.11 ESL05336.1 - 2.9e-20 72.2 9.8 4.2e-20 71.7 6.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESL05336.1 - 8.3e-08 31.2 8.5 1.7e-06 26.9 6.3 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 ESL05336.1 - 0.00093 17.5 2.9 0.0013 17.0 2.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ATG22 PF11700.3 ESL05336.1 - 0.0068 14.9 9.2 0.0081 14.6 5.9 1.5 1 1 1 2 2 2 1 Vacuole effluxer Atg22 like MFS_2 PF13347.1 ESL05336.1 - 0.026 12.9 7.7 0.0053 15.2 1.5 2.1 1 1 1 2 2 2 0 MFS/sugar transport protein DUF3760 PF12586.3 ESL05336.1 - 0.032 14.0 0.1 7.1 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) MFS_1_like PF12832.2 ESL05336.1 - 0.059 13.1 0.2 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 MFS_1 like family HSP70 PF00012.15 ESL05338.1 - 1.6e-268 891.6 6.9 1.8e-268 891.4 4.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL05338.1 - 3.8e-14 52.0 0.2 5.9e-13 48.1 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 ESL05338.1 - 0.00025 20.7 0.1 0.0019 17.8 0.0 2.3 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Asp_decarbox PF02261.11 ESL05338.1 - 0.07 12.7 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Aspartate decarboxylase SRI PF08236.6 ESL05338.1 - 0.094 12.6 0.7 0.23 11.4 0.1 1.9 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain Guanylate_cyc PF00211.15 ESL05339.1 - 5.1e-34 117.2 0.0 7.7e-34 116.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peptidase_M8 PF01457.11 ESL05340.1 - 2.5e-113 379.2 0.0 2.8e-113 379.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Zip PF02535.17 ESL05341.1 - 3.8e-34 118.1 23.6 5.5e-34 117.6 16.3 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Sugar_tr PF00083.19 ESL05342.1 - 1.4e-92 310.6 41.4 1.8e-91 306.9 28.7 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL05342.1 - 3.7e-16 58.7 28.6 1.3e-12 47.1 19.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Syndecan PF01034.15 ESL05342.1 - 0.3 10.7 0.0 0.3 10.7 0.0 3.2 5 0 0 5 5 5 0 Syndecan domain V_ATPase_I PF01496.14 ESL05343.1 - 0.79 7.5 5.7 1.1 7.0 3.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4404 PF14357.1 ESL05343.1 - 1.1 9.7 9.2 0.14 12.6 1.8 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) DUF1451 PF07295.6 ESL05343.1 - 1.3 8.8 8.6 2.4 7.9 2.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) DUF1664 PF07889.7 ESL05343.1 - 1.3 8.7 4.0 1.2 8.9 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SlyX PF04102.7 ESL05343.1 - 1.7 9.1 6.5 1.2 9.5 0.9 2.6 2 0 0 2 2 2 0 SlyX Sec63 PF02889.11 ESL05344.1 - 5.8e-39 134.1 0.0 9.3e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 ESL05344.1 - 1.7e-25 89.5 0.0 2.8e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL05344.1 - 8.7e-06 25.5 0.0 2.2e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL05344.1 - 6.4e-05 22.8 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 ESL05344.1 - 0.0012 17.8 0.0 0.0022 16.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 ESL05344.1 - 0.0054 16.4 0.8 0.027 14.2 0.6 2.3 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 ESL05344.1 - 0.016 15.2 0.2 0.1 12.5 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain UvrD-helicase PF00580.16 ESL05344.1 - 0.023 14.0 0.0 0.29 10.4 0.0 2.0 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain HHH_5 PF14520.1 ESL05344.1 - 0.026 14.7 0.1 0.078 13.1 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain AAA_22 PF13401.1 ESL05344.1 - 0.038 14.1 0.0 0.36 10.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain Ribosom_S12_S23 PF00164.20 ESL05345.1 - 4.5e-39 132.6 0.6 6e-39 132.2 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Peripla_BP_6 PF13458.1 ESL05346.1 - 4.3e-11 42.7 0.4 6e-11 42.2 0.3 1.2 1 0 0 1 1 1 1 Periplasmic binding protein PDH PF02153.12 ESL05346.1 - 0.18 10.6 0.0 4.5 6.0 0.0 2.1 2 0 0 2 2 2 0 Prephenate dehydrogenase GET2 PF08690.5 ESL05347.1 - 0.39 9.9 3.6 0.46 9.6 2.5 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 HMG_box PF00505.14 ESL05347.1 - 0.69 10.2 10.0 3.9 7.8 0.1 2.6 2 1 0 2 2 2 0 HMG (high mobility group) box Aa_trans PF01490.13 ESL05348.1 - 1.3e-31 109.5 6.5 1.6e-31 109.2 4.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL05348.1 - 4.8e-07 28.9 8.4 5.9e-07 28.6 5.8 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESL05348.1 - 0.00021 19.9 9.5 0.00021 19.9 6.6 1.5 1 1 0 1 1 1 1 Amino acid permease Glyco_trans_2_3 PF13632.1 ESL05349.1 - 0.0013 18.4 0.1 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Peptidase_M8 PF01457.11 ESL05350.1 - 7.5e-92 308.3 0.0 2.6e-91 306.5 0.0 1.6 1 1 1 2 2 2 1 Leishmanolysin Reprolysin_3 PF13582.1 ESL05350.1 - 0.00042 20.8 0.0 0.00086 19.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 ESL05350.1 - 0.033 14.2 0.1 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF982 PF06169.7 ESL05350.1 - 0.067 12.9 0.1 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF982) Peptidase_M10 PF00413.19 ESL05350.1 - 0.12 12.1 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Matrixin RHSP PF07999.6 ESL05351.1 - 3.2e-08 32.5 0.1 5.5e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein IZUMO PF15005.1 ESL05352.1 - 0.11 12.5 0.0 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Izumo sperm-egg fusion NOSIC PF08060.8 ESL05355.1 - 5.7e-22 77.2 0.0 1.3e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 ESL05355.1 - 5.5e-18 64.8 0.0 1.1e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Nop PF01798.13 ESL05355.1 - 6.1e-13 48.3 0.1 1.2e-12 47.3 0.1 1.5 1 0 0 1 1 1 1 Putative snoRNA binding domain Ribosomal_S17 PF00366.15 ESL05356.1 - 3.2e-25 87.9 1.3 3.2e-25 87.9 0.9 1.9 2 0 0 2 2 2 1 Ribosomal protein S17 CAF1 PF04857.15 ESL05358.1 - 1e-43 149.6 2.6 1e-43 149.6 1.8 1.5 2 0 0 2 2 2 1 CAF1 family ribonuclease Peptidase_C1 PF00112.18 ESL05360.1 - 1.8e-43 148.9 1.8 2.8e-43 148.3 1.2 1.3 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.3 ESL05360.1 - 1.1e-23 82.9 8.4 1.1e-23 82.9 5.8 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3586) Peptidase_C1_2 PF03051.10 ESL05360.1 - 0.00094 17.8 0.1 0.0012 17.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase C1-like family M20_dimer PF07687.9 ESL05361.1 - 1.3e-13 50.6 0.0 1.9e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESL05361.1 - 0.00087 18.8 0.0 0.00089 18.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 S1FA PF04689.8 ESL05362.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 DNA binding protein S1FA DUF3040 PF11239.3 ESL05362.1 - 0.69 9.9 2.6 1.8 8.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) PMP22_Claudin PF00822.15 ESL05362.1 - 0.91 9.1 3.2 17 5.0 0.1 2.5 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin family DUF3185 PF11381.3 ESL05362.1 - 5.8 6.7 11.2 1.6 8.5 2.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) HSP70 PF00012.15 ESL05364.1 - 2.1e-259 861.4 12.9 2.5e-259 861.2 8.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL05364.1 - 1.3e-19 69.9 0.6 8.1e-17 60.8 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 ESL05364.1 - 0.00018 21.1 0.0 0.00066 19.3 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 ESL05364.1 - 0.0021 17.2 0.1 0.0021 17.2 0.1 2.6 4 0 0 4 4 4 1 Hydantoinase/oxoprolinase RE_HindIII PF09518.5 ESL05364.1 - 0.12 11.3 2.6 0.17 10.7 0.5 2.0 2 0 0 2 2 2 0 HindIII restriction endonuclease Prominin PF05478.6 ESL05365.1 - 0.0058 14.2 2.3 0.0081 13.7 1.6 1.1 1 0 0 1 1 1 1 Prominin Shisa PF13908.1 ESL05365.1 - 0.044 13.9 2.6 0.077 13.1 1.8 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator AJAP1_PANP_C PF15298.1 ESL05365.1 - 0.056 13.3 1.5 0.089 12.6 1.0 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF3481 PF11980.3 ESL05365.1 - 0.078 12.8 3.5 0.12 12.1 0.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3481) TMEM154 PF15102.1 ESL05365.1 - 0.14 11.8 0.1 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Corona_S2 PF01601.11 ESL05365.1 - 1.6 6.7 3.8 2.4 6.1 2.7 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein TPPK_C PF12555.3 ESL05366.1 - 0.0033 17.1 0.1 0.0065 16.1 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphokinase C terminal His_Phos_2 PF00328.17 ESL05366.1 - 0.0046 16.3 0.1 0.0061 15.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Rab3-GTPase_cat PF13890.1 ESL05366.1 - 0.072 12.4 0.0 0.097 12.0 0.0 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit Phage_Coat_B PF05356.6 ESL05366.1 - 2.3 7.9 5.9 2.6 7.7 3.5 1.5 1 1 0 1 1 1 0 Phage Coat protein B Clathrin PF00637.15 ESL05369.1 - 8.2e-09 35.1 2.1 0.18 11.4 0.0 4.3 3 1 1 4 4 4 3 Region in Clathrin and VPS TPR_7 PF13176.1 ESL05369.1 - 0.047 13.5 11.6 7.9 6.5 0.1 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat DZR PF12773.2 ESL05369.1 - 0.14 11.9 7.1 0.67 9.8 4.9 2.2 1 1 0 1 1 1 0 Double zinc ribbon PRP21_like_P PF12230.3 ESL05369.1 - 0.17 11.3 0.7 0.36 10.3 0.5 1.5 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein TPR_11 PF13414.1 ESL05369.1 - 1.6 8.3 18.2 0.91 9.2 0.3 6.0 6 1 1 7 7 7 0 TPR repeat TPR_14 PF13428.1 ESL05369.1 - 1.8 9.4 15.4 8.3 7.3 0.1 7.0 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL05369.1 - 6.5 6.7 15.8 39 4.2 0.1 6.3 5 1 2 7 7 7 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL05370.1 - 2.2e-34 118.8 0.0 2.6e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05370.1 - 3.3e-15 55.8 0.0 3.8e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL05370.1 - 3.2e-06 27.0 0.1 0.00073 19.3 0.0 2.9 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL05370.1 - 0.015 14.4 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL05370.1 - 0.041 12.8 0.0 0.2 10.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESL05370.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TPR_12 PF13424.1 ESL05371.1 - 4.8e-06 26.4 0.2 0.14 12.1 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL05371.1 - 0.00068 19.2 0.0 0.2 11.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL05371.1 - 0.001 18.7 0.0 0.055 13.4 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat IQ PF00612.22 ESL05371.1 - 0.0041 16.6 0.0 0.015 14.9 0.0 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif TPR_11 PF13414.1 ESL05371.1 - 0.0045 16.5 0.1 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 ESL05371.1 - 0.031 13.8 0.0 0.65 9.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Amidinotransf PF02274.12 ESL05372.1 - 2.1e-05 23.7 0.0 7.4e-05 21.9 0.0 1.7 1 1 0 1 1 1 1 Amidinotransferase Pkinase PF00069.20 ESL05373.1 - 2e-55 187.7 0.0 2.8e-55 187.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05373.1 - 1.8e-32 112.4 0.0 2.9e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05373.1 - 0.044 12.7 0.0 0.074 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RYDR_ITPR PF01365.16 ESL05373.1 - 0.51 9.5 0.0 0.86 8.7 0.0 1.2 1 0 0 1 1 1 0 RIH domain zf-DHHC PF01529.15 ESL05375.1 - 2e-26 92.4 7.6 4e-26 91.4 5.2 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase zf-C2H2_2 PF12756.2 ESL05376.1 - 2.5e-16 59.6 4.7 7.4e-13 48.4 0.1 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) CENP-B_dimeris PF09026.5 ESL05376.1 - 0.016 15.3 0.2 0.034 14.3 0.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GSHPx PF00255.14 ESL05377.1 - 5e-37 125.5 0.0 6.5e-37 125.2 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 ESL05377.1 - 0.0081 15.8 0.0 0.014 15.0 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESL05377.1 - 0.081 12.4 0.0 0.16 11.5 0.0 1.6 1 1 0 1 1 1 0 Redoxin Peptidase_M8 PF01457.11 ESL05378.1 - 1.6e-127 426.0 0.0 2e-127 425.7 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_3 PF13582.1 ESL05378.1 - 0.00034 21.1 0.1 0.00072 20.0 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 ESL05378.1 - 0.023 14.2 0.1 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.3 ESL05378.1 - 0.025 13.8 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.1 ESL05378.1 - 0.11 12.3 0.3 0.25 11.2 0.2 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12 Astacin PF01400.19 ESL05378.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Aa_trans PF01490.13 ESL05379.1 - 5e-50 170.1 32.0 5.8e-50 169.9 22.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TPR_14 PF13428.1 ESL05380.1 - 1.2e-09 37.8 3.0 0.0019 18.6 0.0 5.7 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESL05380.1 - 1.8e-08 33.8 4.5 3.5e-05 23.3 0.0 4.7 5 0 0 5 5 5 1 TPR repeat TPR_19 PF14559.1 ESL05380.1 - 1.2e-07 31.9 0.3 0.052 13.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL05380.1 - 1.9e-05 25.2 3.6 0.08 13.6 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL05380.1 - 0.00012 21.7 6.1 0.37 10.8 0.0 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL05380.1 - 0.0039 16.7 0.4 17 5.2 0.0 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL05380.1 - 0.011 15.4 0.6 0.25 11.2 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESL05380.1 - 0.018 15.2 6.2 0.16 12.2 0.0 4.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL05380.1 - 0.04 14.3 0.1 3.2 8.4 0.0 3.7 2 1 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.11 ESL05381.1 - 1.7e-22 79.6 39.8 9.1e-22 77.2 27.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 ESL05381.1 - 1.3e-11 43.2 24.5 1e-05 23.8 2.4 3.4 2 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.19 ESL05381.1 - 5e-07 28.6 35.7 6.9e-05 21.5 24.8 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter Lig_chan PF00060.21 ESL05381.1 - 0.062 13.0 1.4 0.7 9.5 0.1 2.9 2 1 0 2 2 2 0 Ligand-gated ion channel GalKase_gal_bdg PF10509.4 ESL05382.1 - 1.1e-18 66.1 0.1 2.8e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 ESL05382.1 - 4.7e-09 36.3 0.0 1e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESL05382.1 - 0.00037 20.5 0.0 0.00087 19.3 0.0 1.6 1 1 0 1 1 1 1 GHMP kinases N terminal domain Cation_efflux PF01545.16 ESL05383.1 - 7.6e-57 192.5 5.3 9e-57 192.3 3.7 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ESL05383.1 - 0.00042 19.4 4.4 0.00087 18.3 3.0 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Peptidase_M8 PF01457.11 ESL05384.1 - 2.9e-89 299.7 0.4 3.5e-89 299.5 0.2 1.0 1 0 0 1 1 1 1 Leishmanolysin ATP-grasp_2 PF08442.5 ESL05385.1 - 9.6e-63 211.2 0.9 1.5e-62 210.5 0.6 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 ESL05385.1 - 6.4e-23 81.0 0.4 1.6e-22 79.7 0.1 1.8 2 0 0 2 2 2 1 CoA-ligase GARS_A PF01071.14 ESL05385.1 - 0.0036 16.9 0.7 0.014 15.0 0.5 1.9 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pkinase PF00069.20 ESL05386.1 - 4.5e-27 94.8 0.0 8.1e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05386.1 - 5e-22 78.2 0.0 2e-21 76.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05386.1 - 0.00012 21.1 0.0 0.0002 20.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like eIF2A PF08662.6 ESL05388.1 - 8.7e-41 139.7 0.1 1.1e-32 113.3 0.0 3.1 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A FCP1_C PF09309.5 ESL05388.1 - 0.1 11.8 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 FCP1, C-terminal Laminin_G_3 PF13385.1 ESL05389.1 - 1.7e-11 44.6 1.3 1.7e-11 44.5 0.2 1.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Histone PF00125.19 ESL05390.1 - 2.6e-17 62.6 0.6 3.9e-17 62.1 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL05390.1 - 0.00063 19.7 0.2 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pex24p PF06398.6 ESL05390.1 - 0.02 13.6 0.0 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Ctr PF04145.10 ESL05390.1 - 0.061 13.3 0.5 0.083 12.9 0.3 1.3 1 1 0 1 1 1 0 Ctr copper transporter family Galactosyl_T PF01762.16 ESL05391.1 - 0.0067 16.0 0.0 6.7 6.2 0.0 3.0 3 0 0 3 3 3 2 Galactosyltransferase HECT PF00632.20 ESL05392.1 - 5.9e-09 35.5 0.0 0.0015 17.7 0.0 3.9 3 1 0 4 4 4 3 HECT-domain (ubiquitin-transferase) CpeS PF09367.5 ESL05392.1 - 0.00027 20.8 0.0 0.00042 20.2 0.0 1.2 1 0 0 1 1 1 1 CpeS-like protein FAD_binding_1 PF00667.15 ESL05392.1 - 0.04 13.3 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Glycos_transf_2 PF00535.21 ESL05394.1 - 1.1e-05 25.1 0.0 2.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESL05394.1 - 0.00079 19.2 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESL05394.1 - 0.0012 18.0 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESL05394.1 - 0.0026 17.4 0.1 0.0065 16.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 UIM PF02809.15 ESL05394.1 - 4.3 7.1 5.3 2.2 8.0 0.9 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Beta_helix PF13229.1 ESL05396.1 - 0.00052 19.7 7.3 0.029 14.1 0.1 5.0 4 2 2 6 6 6 2 Right handed beta helix region CCDC144C PF14915.1 ESL05397.1 - 0.021 13.7 9.2 0.035 13.0 6.3 1.3 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF2207 PF09972.4 ESL05397.1 - 0.029 12.9 0.0 0.041 12.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1381 PF07129.6 ESL05397.1 - 0.099 12.0 0.2 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1381) DUF3752 PF12572.3 ESL05397.1 - 1.4 9.0 9.0 0.077 13.1 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3752) MFS_1 PF07690.11 ESL05399.1 - 5.9e-17 61.4 39.1 6.6e-12 44.7 17.3 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05399.1 - 2.5e-09 36.7 22.7 1.2e-08 34.5 14.0 2.7 2 1 0 2 2 2 1 Nodulin-like EGF_2 PF07974.8 ESL05400.1 - 7.7 6.7 72.8 0.059 13.5 7.9 6.0 5 2 0 5 5 5 0 EGF-like domain BNR_3 PF13859.1 ESL05402.1 - 7.2e-21 74.5 0.0 9.3e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Ribosomal_L30 PF00327.15 ESL05403.1 - 4.1e-18 64.7 1.0 1e-17 63.4 0.7 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 ESL05403.1 - 9.1e-17 60.8 12.4 1.7e-16 60.0 8.6 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Nudix_N_2 PF14803.1 ESL05404.1 - 2.6 7.8 5.5 20 4.9 3.7 2.4 1 1 1 2 2 2 0 Nudix N-terminal DUF21 PF01595.15 ESL05405.1 - 3.5e-14 52.4 0.0 8.3e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESL05405.1 - 2.2e-05 24.1 0.0 0.1 12.4 0.0 3.2 2 2 0 2 2 2 2 CBS domain Myotub-related PF06602.9 ESL05406.1 - 1.5e-67 227.8 0.6 1.7e-39 135.6 0.2 2.4 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Y_phosphatase PF00102.22 ESL05406.1 - 0.45 9.8 0.0 0.8 8.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FtsX PF02687.16 ESL05407.1 - 4.1 7.2 12.4 6.8 6.4 0.1 2.5 2 0 0 2 2 2 0 FtsX-like permease family DUF898 PF05987.8 ESL05407.1 - 6.5 5.5 13.1 0.13 11.1 0.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) EF-hand_6 PF13405.1 ESL05408.1 - 0.00059 19.5 0.1 0.65 10.0 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain Clathrin PF00637.15 ESL05409.1 - 2.7e-157 516.5 31.2 4.8e-26 91.0 0.1 8.2 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 ESL05409.1 - 9.4e-21 73.4 0.0 3.9e-20 71.5 0.0 2.2 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.15 ESL05409.1 - 1.5e-19 68.8 0.8 0.015 15.5 0.0 7.0 7 0 0 7 7 7 4 Clathrin propeller repeat Clathrin-link PF09268.5 ESL05409.1 - 8.6e-10 37.4 0.0 3.3e-09 35.5 0.0 2.1 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_14 PF13428.1 ESL05409.1 - 7.7e-06 26.0 14.1 1.4 9.7 0.0 9.7 10 1 0 10 10 10 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL05409.1 - 0.00014 21.3 0.1 9.9 6.2 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL05409.1 - 0.0028 17.2 2.8 7.2 6.4 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF3114 PF11311.3 ESL05409.1 - 0.15 11.4 0.0 0.15 11.4 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3114) Ribosomal_L10 PF00466.15 ESL05410.1 - 3.4e-25 87.8 0.2 6.6e-25 86.9 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 ESL05410.1 - 4.2e-16 59.1 10.7 4.2e-16 59.1 7.4 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein DIOX_N PF14226.1 ESL05411.1 - 4.3e-34 117.5 0.0 5.9e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESL05411.1 - 6.6e-24 84.0 0.0 1e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HECT PF00632.20 ESL05412.1 - 4.1e-56 190.4 0.0 8e-56 189.4 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESL05412.1 - 2.9e-37 127.5 2.9 3.8e-17 62.5 0.1 3.7 3 0 0 3 3 3 3 SPRY domain Laminin_G_3 PF13385.1 ESL05412.1 - 1e-07 32.3 0.5 0.0058 16.8 0.0 3.0 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily DIOX_N PF14226.1 ESL05413.1 - 3.3e-33 114.6 0.0 4.8e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESL05413.1 - 1.1e-24 86.5 0.0 1.8e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Arf PF00025.16 ESL05415.1 - 3.8e-58 195.5 0.0 4.3e-58 195.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 ESL05415.1 - 8.2e-10 39.2 0.0 1.1e-09 38.8 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 ESL05415.1 - 6.6e-09 34.9 0.4 2e-06 26.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 ESL05415.1 - 1.1e-08 34.5 0.0 1.4e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 ESL05415.1 - 1.2e-08 34.5 0.0 1.4e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 ESL05415.1 - 6.3e-07 29.3 0.0 9.4e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL05415.1 - 3.8e-06 26.4 0.2 0.0016 17.9 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL05415.1 - 9.9e-05 21.5 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.13 ESL05415.1 - 0.0011 18.2 0.1 0.0092 15.2 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B cobW PF02492.14 ESL05415.1 - 0.013 14.9 0.1 0.86 9.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 ESL05415.1 - 0.024 14.1 0.0 0.06 12.8 0.0 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.17 ESL05415.1 - 0.032 13.6 0.1 0.058 12.8 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.1 ESL05415.1 - 0.034 14.1 0.1 0.38 10.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain Abhydrolase_6 PF12697.2 ESL05416.1 - 6.7e-17 62.1 0.0 8.9e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL05416.1 - 1.2e-11 44.6 0.0 2.5e-11 43.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL05416.1 - 1.1e-06 28.4 0.0 1.1e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESL05416.1 - 0.00037 19.7 0.0 0.14 11.3 0.0 2.7 2 1 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.13 ESL05416.1 - 0.0061 15.8 0.0 0.93 8.7 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Kinesin PF00225.18 ESL05417.1 - 2.3e-45 154.7 6.8 3.3e-45 154.2 0.0 2.6 2 1 0 2 2 2 1 Kinesin motor domain DUF4410 PF14366.1 ESL05417.1 - 0.78 9.4 6.3 1.2 8.8 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) FliL PF03748.9 ESL05417.1 - 5.4 7.0 18.2 0.083 12.8 4.2 3.5 3 1 0 3 3 3 0 Flagellar basal body-associated protein FliL Peptidase_M8 PF01457.11 ESL05418.1 - 8.2e-117 390.6 0.9 5.5e-59 199.8 0.8 2.0 2 0 0 2 2 2 2 Leishmanolysin Astacin PF01400.19 ESL05418.1 - 0.096 12.0 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) FANCL_C PF11793.3 ESL05419.1 - 0.07 13.1 3.8 0.25 11.3 2.6 2.0 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.1 ESL05419.1 - 0.19 11.3 3.8 0.66 9.6 2.6 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL05419.1 - 0.29 10.8 3.8 0.9 9.2 2.6 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 ESL05419.1 - 1.6 8.8 5.4 3.9 7.5 3.8 1.8 1 0 0 1 1 1 0 RING-variant domain BUD22 PF09073.5 ESL05419.1 - 8.2 5.3 6.8 13 4.6 4.7 1.2 1 0 0 1 1 1 0 BUD22 ECH PF00378.15 ESL05420.1 - 1.3e-54 184.8 0.0 1.6e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Cpn60_TCP1 PF00118.19 ESL05421.1 - 1.4e-05 23.9 0.0 1.9e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family STT3 PF02516.9 ESL05422.1 - 1.2e-34 120.1 26.7 3.3e-33 115.3 18.5 2.0 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT PF02366.13 ESL05422.1 - 2.7e-05 23.6 13.1 2.7e-05 23.6 9.0 2.5 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PGK PF00162.14 ESL05423.1 - 6.8e-103 344.1 0.1 7.6e-103 344.0 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase NIF PF03031.13 ESL05424.1 - 6.5e-49 165.6 0.0 9.4e-49 165.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Peptidase_M8 PF01457.11 ESL05425.1 - 6e-101 338.3 0.0 7.5e-101 338.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Caenor_Her-1 PF09232.5 ESL05425.1 - 0.089 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis elegans Her-1 Med15 PF09606.5 ESL05426.1 - 0.00053 18.3 4.5 0.00071 17.9 3.1 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.3 ESL05426.1 - 0.045 13.1 0.3 0.22 10.8 0.2 1.9 2 0 0 2 2 2 0 Spt20 family Activator_LAG-3 PF11498.3 ESL05426.1 - 0.91 8.2 13.8 1.4 7.5 9.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med3 PF11593.3 ESL05426.1 - 5.3 6.1 10.7 8.1 5.5 7.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Methyltransf_PK PF05891.7 ESL05427.1 - 1.9e-33 115.5 0.0 2.4e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_11 PF08241.7 ESL05427.1 - 8.8e-05 22.9 0.0 0.00013 22.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESL05427.1 - 0.0036 16.7 0.0 0.0045 16.3 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_31 PF13847.1 ESL05427.1 - 0.0059 16.2 0.0 0.011 15.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL05427.1 - 0.045 14.3 0.0 0.07 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_S5_C PF03719.10 ESL05428.1 - 8e-25 85.9 0.0 1.3e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 ESL05428.1 - 3.5e-19 68.3 2.0 4.9e-19 67.8 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain eIF3g PF12353.3 ESL05429.1 - 0.00014 21.8 6.7 0.021 14.7 1.8 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_3 PF13917.1 ESL05429.1 - 0.01 15.5 7.8 0.032 13.9 0.0 2.7 3 0 0 3 3 3 0 Zinc knuckle zf-C4pol PF14260.1 ESL05429.1 - 0.29 11.1 5.6 2.2 8.3 2.2 2.4 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Zn_Tnp_IS1595 PF12760.2 ESL05429.1 - 1.4 8.7 8.4 22 4.9 0.0 3.4 3 0 0 3 3 3 0 Transposase zinc-ribbon domain EMP70 PF02990.11 ESL05430.1 - 9.1e-100 334.5 12.4 1.2e-99 334.2 8.6 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF3976 PF13121.1 ESL05430.1 - 0.17 11.7 3.2 5.7 6.8 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3976) ABC_membrane PF00664.18 ESL05431.1 - 1.4e-53 182.1 25.1 2.6e-30 105.7 9.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESL05431.1 - 1e-45 155.3 0.0 1.2e-26 93.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESL05431.1 - 3.6e-11 42.7 0.5 0.00082 18.6 0.0 4.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESL05431.1 - 1.3e-08 34.2 1.4 0.00014 21.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 ESL05431.1 - 1.3e-07 31.1 0.5 0.01 15.2 0.0 3.0 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 ESL05431.1 - 1.1e-06 27.9 0.3 0.0013 17.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESL05431.1 - 1.2e-06 28.6 1.5 0.011 15.6 0.1 3.1 2 1 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 ESL05431.1 - 2.5e-05 24.7 0.2 0.26 11.8 0.1 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_21 PF13304.1 ESL05431.1 - 3.1e-05 24.0 0.0 1.8 8.4 0.0 4.1 2 2 1 4 4 4 2 AAA domain MMR_HSR1 PF01926.18 ESL05431.1 - 3.7e-05 23.6 0.8 0.26 11.2 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF87 PF01935.12 ESL05431.1 - 0.00022 21.1 4.4 0.18 11.5 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function DUF87 T2SE PF00437.15 ESL05431.1 - 0.00042 19.3 0.3 0.72 8.6 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_23 PF13476.1 ESL05431.1 - 0.00044 20.6 0.3 0.038 14.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 ESL05431.1 - 0.00047 19.6 1.4 0.31 10.4 0.1 2.4 2 0 0 2 2 2 2 AAA-like domain Dynamin_N PF00350.18 ESL05431.1 - 0.0008 19.2 0.2 0.81 9.4 0.0 2.3 2 0 0 2 2 2 2 Dynamin family AAA_22 PF13401.1 ESL05431.1 - 0.001 19.2 0.0 1.5 8.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.20 ESL05431.1 - 0.0028 17.2 0.1 0.65 9.4 0.0 2.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ArgK PF03308.11 ESL05431.1 - 0.0028 16.4 1.7 0.083 11.6 0.1 2.2 2 0 0 2 2 2 1 ArgK protein Viral_helicase1 PF01443.13 ESL05431.1 - 0.0035 16.8 0.0 2.2 7.7 0.1 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.1 ESL05431.1 - 0.0049 17.6 0.7 5.6 7.7 0.6 2.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESL05431.1 - 0.0052 16.2 1.6 1.2 8.6 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family MobB PF03205.9 ESL05431.1 - 0.0057 16.3 2.5 1.8 8.3 0.3 2.8 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 ESL05431.1 - 0.058 13.2 3.3 0.34 10.7 0.2 2.9 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 ESL05431.1 - 0.11 12.2 4.3 1.8 8.2 0.1 3.4 3 0 0 3 3 3 0 NACHT domain AAA_18 PF13238.1 ESL05431.1 - 0.17 12.2 1.7 9.1 6.5 0.3 2.4 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.10 ESL05431.1 - 0.19 10.3 0.1 4.7 5.7 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein cobW PF02492.14 ESL05431.1 - 0.19 11.1 3.9 2.9 7.2 0.3 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.4 ESL05431.1 - 0.24 9.9 1.6 5.9 5.4 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain WD40 PF00400.27 ESL05432.1 - 5e-13 48.3 6.0 0.00014 21.5 0.3 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Aa_trans PF01490.13 ESL05433.1 - 1.4e-38 132.4 14.9 2e-38 131.9 10.4 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL05433.1 - 6.9e-05 21.8 12.2 0.00013 20.9 8.5 1.3 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Nucleoside_tran PF01733.13 ESL05434.1 - 1e-18 67.5 0.3 1e-18 67.5 0.2 1.4 2 0 0 2 2 2 1 Nucleoside transporter AIG1 PF04548.11 ESL05434.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.4 1 0 0 1 1 1 0 AIG1 family PHO4 PF01384.15 ESL05435.1 - 7e-106 353.5 25.6 9.1e-106 353.1 17.7 1.1 1 0 0 1 1 1 1 Phosphate transporter family Myco_arth_vir_N PF09610.5 ESL05435.1 - 0.08 12.9 0.4 0.68 9.9 0.0 2.9 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimer_Tnp_hAT PF05699.9 ESL05435.1 - 0.19 11.3 1.3 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region BT1 PF03092.11 ESL05436.1 - 6.1e-151 502.9 7.7 7.5e-151 502.6 5.4 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 ESL05436.1 - 0.01 14.5 0.3 0.01 14.5 0.2 4.7 2 2 2 4 4 4 0 Major Facilitator Superfamily DUF2475 PF10629.4 ESL05437.1 - 0.0029 17.8 1.4 0.0073 16.5 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2475) DUF1989 PF09347.5 ESL05438.1 - 0.11 11.9 0.1 1.6 8.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1989) MAAL_C PF07476.6 ESL05439.1 - 0.079 11.8 0.1 0.23 10.3 0.0 1.7 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus DUF148 PF02520.12 ESL05439.1 - 0.58 9.9 7.4 2.6 7.8 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function DUF148 NPV_P10 PF05531.7 ESL05439.1 - 3.6 7.9 7.3 8.7 6.6 0.1 3.9 3 3 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Peptidase_M90 PF06167.7 ESL05440.1 - 0.091 12.1 0.2 0.13 11.6 0.2 1.3 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Cytochrom_C PF00034.16 ESL05441.1 - 2.1e-10 41.2 0.0 2.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 ESL05441.1 - 0.00018 21.6 2.3 0.00088 19.3 1.6 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III CLN3 PF02487.12 ESL05442.1 - 3.7e-33 114.9 33.9 1.2e-17 63.7 3.4 4.0 3 1 0 3 3 3 3 CLN3 protein Gp_dh_C PF02800.15 ESL05443.1 - 5e-73 243.7 0.1 6.1e-73 243.4 0.1 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL05443.1 - 3.3e-10 40.1 0.0 7.9e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GATase PF00117.23 ESL05444.1 - 5e-10 39.1 0.0 6.7e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESL05444.1 - 5.1e-07 29.3 1.3 1.1e-05 25.0 0.2 2.6 2 1 0 2 2 2 1 Peptidase C26 E1-E2_ATPase PF00122.15 ESL05445.1 - 1.2e-43 148.8 1.9 1.3e-43 148.6 0.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESL05445.1 - 1e-23 84.9 0.0 6.8e-23 82.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 ESL05445.1 - 1.3e-18 67.2 0.1 1.3e-18 67.2 0.1 1.6 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase_like2 PF13246.1 ESL05445.1 - 2.4e-10 40.2 0.0 5.9e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESL05445.1 - 1.9e-09 37.9 0.0 6.5e-09 36.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL05445.1 - 3.4e-05 23.5 0.0 0.00064 19.3 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Peptidase_C14 PF00656.17 ESL05447.1 - 1.6e-59 201.5 0.0 2e-59 201.2 0.0 1.0 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.1 ESL05447.1 - 0.045 13.5 0.1 7.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain Peptidase_M8 PF01457.11 ESL05448.1 - 1.3e-53 182.2 0.2 1.4e-53 182.0 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESL05448.1 - 0.07 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Matrixin Hexokinase_1 PF00349.16 ESL05450.1 - 4.6e-64 215.5 0.1 6.9e-64 214.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 ESL05450.1 - 4.2e-58 196.4 0.1 5.9e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase CDC73 PF05179.9 ESL05451.1 - 2.1e-16 60.1 0.0 2.6e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family ATP-synt_ab PF00006.20 ESL05453.1 - 2.3e-49 167.8 0.0 1.2e-48 165.4 0.0 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL05453.1 - 2.4e-22 79.5 0.4 4e-22 78.8 0.3 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain S4 PF01479.20 ESL05454.1 - 0.22 10.9 1.0 0.59 9.6 0.6 1.8 1 1 0 1 1 1 0 S4 domain zf-MYND PF01753.13 ESL05455.1 - 2.4e-05 24.0 8.0 7.5e-05 22.5 5.6 1.9 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.1 ESL05455.1 - 0.31 10.9 3.8 0.85 9.5 2.6 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Pex19 PF04614.7 ESL05457.1 - 1.3e-13 51.1 7.8 3.8e-13 49.6 0.6 2.9 1 1 1 2 2 2 1 Pex19 protein family IBB PF01749.15 ESL05457.1 - 0.0045 17.1 0.3 0.01 15.9 0.2 1.6 1 0 0 1 1 1 1 Importin beta binding domain Flagellin_N PF00669.15 ESL05457.1 - 0.013 15.2 2.4 0.035 13.9 1.1 1.9 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region MCPsignal PF00015.16 ESL05457.1 - 0.022 14.3 0.1 0.056 12.9 0.0 1.6 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Reo_sigmaC PF04582.7 ESL05457.1 - 0.022 13.9 0.3 0.82 8.7 0.1 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Leader_Thr PF08254.6 ESL05457.1 - 1.4 8.7 4.9 0.38 10.4 0.3 2.3 2 0 0 2 2 2 0 Threonine leader peptide FUSC PF04632.7 ESL05457.1 - 2 6.7 4.2 0.63 8.4 0.1 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family Lipoprotein_6 PF01441.14 ESL05458.1 - 0.026 14.3 0.5 0.07 12.9 0.4 1.6 1 0 0 1 1 1 0 Lipoprotein DUF4081 PF13312.1 ESL05458.1 - 0.069 13.0 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) DUF1664 PF07889.7 ESL05458.1 - 0.32 10.7 5.7 0.15 11.8 1.0 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) TBPIP PF07106.8 ESL05458.1 - 0.89 9.0 8.5 0.51 9.8 1.7 3.0 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF342 PF03961.8 ESL05458.1 - 2 6.7 10.6 0.21 9.9 2.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF342) DUF904 PF06005.7 ESL05458.1 - 3.4 8.0 15.3 0.088 13.1 1.7 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF904) MFS_1 PF07690.11 ESL05459.1 - 1.1e-19 70.3 32.3 8.4e-16 57.6 22.4 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05459.1 - 8.9e-13 48.0 20.1 2.5e-11 43.3 13.9 2.6 1 1 0 1 1 1 1 Nodulin-like RHSP PF07999.6 ESL05461.1 - 1.1e-11 43.9 0.0 1.6e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Ldh_1_C PF02866.13 ESL05463.1 - 3.3e-28 98.5 0.0 4.5e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 ESL05463.1 - 2.8e-08 33.6 0.0 5.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain BNR_3 PF13859.1 ESL05464.1 - 1.5e-48 165.4 0.0 2.2e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESL05464.1 - 2.4e-13 50.6 0.3 7.5e-13 49.0 0.1 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESL05464.1 - 3.3e-10 39.7 0.1 5.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESL05464.1 - 2.4e-05 23.5 1.7 0.2 11.5 0.2 3.2 2 0 0 2 2 2 2 BNR/Asp-box repeat Radial_spoke PF04712.7 ESL05465.1 - 1.2e-115 387.1 20.2 7e-113 377.9 14.0 2.1 1 1 0 1 1 1 1 Radial spokehead-like protein Ribosomal_L3 PF00297.17 ESL05466.1 - 6.1e-13 48.7 0.1 1e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L3 Peptidase_M8 PF01457.11 ESL05467.1 - 5.6e-102 341.7 5.4 3.6e-101 339.0 3.7 1.9 1 1 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESL05467.1 - 0.019 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF1469 PF07332.6 ESL05467.1 - 0.063 13.0 9.6 0.33 10.7 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF3810 PF12725.2 ESL05467.1 - 0.12 11.2 0.2 0.2 10.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) NeuB PF03102.9 ESL05468.1 - 0.0012 18.0 0.0 0.0016 17.6 0.0 1.1 1 0 0 1 1 1 1 NeuB family Pro_isomerase PF00160.16 ESL05469.1 - 1.7e-07 31.5 0.0 2.2e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_L19e PF01280.15 ESL05470.1 - 0.025 14.3 1.1 3.9 7.2 0.3 2.3 2 0 0 2 2 2 0 Ribosomal protein L19e Ribosomal_S3_C PF00189.15 ESL05471.1 - 4.6e-17 62.0 0.9 5.4e-17 61.7 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain BNR_3 PF13859.1 ESL05472.1 - 1.8e-86 289.9 0.1 2.5e-86 289.5 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain YchF-GTPase_C PF06071.8 ESL05473.1 - 3.6e-38 129.2 1.2 6.8e-38 128.3 0.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 ESL05473.1 - 8.8e-06 25.6 0.0 2e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 ESL05473.1 - 0.0029 17.3 0.0 0.0086 15.8 0.0 1.8 1 0 0 1 1 1 1 TGS domain Aldose_epim PF01263.15 ESL05475.1 - 1.6e-50 171.9 0.0 2.1e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase FUSC_2 PF13515.1 ESL05476.1 - 0.0015 18.4 15.5 0.003 17.4 10.8 1.5 1 0 0 1 1 1 1 Fusaric acid resistance protein-like DUF939 PF06081.6 ESL05476.1 - 1.8 8.4 13.7 0.73 9.6 5.7 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF939) Dzip-like_N PF13815.1 ESL05477.1 - 3e-38 130.2 2.5 3e-38 130.2 1.7 2.3 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal zf-C2H2 PF00096.21 ESL05477.1 - 0.00061 19.9 0.8 0.0012 19.0 0.5 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESL05477.1 - 0.0093 16.2 0.3 0.02 15.1 0.2 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESL05477.1 - 0.086 12.9 1.2 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF3505 PF12013.3 ESL05477.1 - 2.4 8.4 8.0 0.16 12.2 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3505) Ribosomal_S7 PF00177.16 ESL05478.1 - 1.7e-36 125.0 0.2 2e-36 124.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Aa_trans PF01490.13 ESL05479.1 - 5e-29 101.0 14.7 5.7e-29 100.8 10.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Isochorismatase PF00857.15 ESL05480.1 - 1.6e-23 83.5 0.0 1.9e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family EF-hand_1 PF00036.27 ESL05481.1 - 1.9e-09 36.1 1.2 1.8e-08 33.0 0.0 2.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 ESL05481.1 - 6e-09 35.9 0.2 8.4e-09 35.4 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL05481.1 - 1.3e-07 31.0 0.6 0.0016 18.0 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL05481.1 - 6.4e-07 28.7 0.3 5.3e-06 25.8 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 ESL05481.1 - 9e-06 24.7 0.6 2.3e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 EF hand Colicin_Pyocin PF01320.13 ESL05481.1 - 0.049 13.5 0.2 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 Colicin immunity protein / pyocin immunity protein LNS2 PF08235.8 ESL05481.1 - 0.067 12.7 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Baculo_p48 PF04878.8 ESL05481.1 - 0.074 11.9 0.0 0.12 11.2 0.0 1.2 1 1 0 1 1 1 0 Baculovirus P48 protein DAP3 PF10236.4 ESL05481.1 - 0.14 11.0 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Peptidase_M20 PF01546.23 ESL05482.1 - 2e-20 73.0 0.0 3e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL05482.1 - 5.2e-13 48.7 0.0 8.1e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF3522 PF12036.3 ESL05483.1 - 1.7e-55 187.7 2.9 2e-55 187.4 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) ASFV_L11L PF05293.6 ESL05483.1 - 0.012 15.7 2.4 0.024 14.7 0.7 2.1 2 0 0 2 2 2 0 African swine fever virus (ASFV) L11L protein Ceramidase PF05875.7 ESL05483.1 - 7.6 5.5 10.7 0.24 10.4 1.0 2.5 2 1 0 2 2 2 0 Ceramidase Transket_pyr PF02779.19 ESL05485.1 - 6.4e-46 156.0 0.0 2e-45 154.4 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESL05485.1 - 3.3e-39 133.6 0.1 3.6e-37 127.0 0.0 2.3 2 0 0 2 2 2 2 Transketolase, C-terminal domain Ribosomal_L44 PF00935.14 ESL05487.1 - 1.3e-31 108.3 8.0 2e-31 107.8 5.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 RNHCP PF12647.2 ESL05487.1 - 0.17 11.6 2.8 0.35 10.7 0.1 2.0 1 1 1 2 2 2 0 RNHCP domain Peptidase_M20 PF01546.23 ESL05488.1 - 9.9e-26 90.4 0.2 1.4e-25 89.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL05488.1 - 9.4e-09 35.0 0.0 1.8e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 ESL05488.1 - 0.014 15.1 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 TMEM247 PF15444.1 ESL05490.1 - 7e-05 22.7 1.7 7e-05 22.7 1.2 3.0 3 0 0 3 3 3 1 Transmembrane protein 247 Tmemb_cc2 PF10267.4 ESL05490.1 - 0.0018 16.9 7.7 0.0018 16.9 5.4 3.0 2 1 1 3 3 3 1 Predicted transmembrane and coiled-coil 2 protein Helicase_RecD PF05127.9 ESL05490.1 - 0.098 12.2 3.2 0.2 11.2 0.4 2.3 2 0 0 2 2 2 0 Helicase DUF641 PF04859.7 ESL05490.1 - 0.43 10.3 22.6 0.042 13.6 0.7 3.6 2 1 2 4 4 4 0 Plant protein of unknown function (DUF641) ERM PF00769.14 ESL05490.1 - 1.4 8.4 41.6 0.018 14.6 2.4 3.2 2 1 1 3 3 3 0 Ezrin/radixin/moesin family DUF342 PF03961.8 ESL05490.1 - 2.8 6.2 17.7 1.5 7.1 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF342) Allexi_40kDa PF05549.6 ESL05490.1 - 8.7 5.5 13.6 8.8 5.5 3.4 3.1 2 1 0 2 2 2 0 Allexivirus 40kDa protein Pkinase PF00069.20 ESL05491.1 - 1.4e-60 204.6 0.0 2.3e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05491.1 - 3.1e-45 154.2 0.0 6.5e-45 153.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL05491.1 - 0.042 13.5 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESL05491.1 - 0.096 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mito_carr PF00153.22 ESL05492.1 - 5.4e-69 227.9 4.9 1.5e-25 88.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF4257 PF14074.1 ESL05492.1 - 0.00092 18.8 0.0 0.68 9.6 0.1 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF4257) ELO PF01151.13 ESL05493.1 - 2.5e-75 253.0 20.1 3.1e-75 252.7 14.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family GTP_EFTU PF00009.22 ESL05495.1 - 1.1e-61 207.5 0.2 1.8e-61 206.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESL05495.1 - 9.3e-36 122.0 0.0 2.2e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 ESL05495.1 - 3.3e-21 74.9 0.0 8.2e-21 73.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 ESL05495.1 - 7e-14 51.4 0.1 2.3e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESL05495.1 - 6.3e-13 48.6 0.1 2.1e-12 46.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Rep_fac_C PF08542.6 ESL05497.1 - 1.2e-15 57.2 0.0 2.3e-15 56.3 0.0 1.5 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESL05497.1 - 3.9e-05 23.3 0.1 6.3e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.8 ESL05497.1 - 0.00038 19.9 0.0 0.00076 19.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF3834 PF12916.2 ESL05497.1 - 0.011 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) Rad17 PF03215.10 ESL05497.1 - 0.073 11.7 0.0 0.097 11.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein zf-CCHC_2 PF13696.1 ESL05498.1 - 1.8e-06 27.3 5.5 1.8e-06 27.3 3.8 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 ESL05498.1 - 0.037 13.9 4.0 0.037 13.9 2.8 2.3 3 0 0 3 3 3 0 Zinc knuckle zf-RING_5 PF14634.1 ESL05498.1 - 0.12 12.1 8.7 0.27 11.0 1.7 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Zn-ribbon_8 PF09723.5 ESL05498.1 - 0.14 12.0 4.4 1 9.3 0.4 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-C3HC4_2 PF13923.1 ESL05498.1 - 2.8 8.0 8.5 0.3 11.1 1.6 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ENTH PF01417.15 ESL05499.1 - 1e-26 93.2 0.0 1.7e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 ENTH domain DUF572 PF04502.8 ESL05499.1 - 0.31 10.2 7.8 0.48 9.5 5.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Pox_I5 PF04713.7 ESL05501.1 - 0.036 13.7 0.3 0.067 12.9 0.2 1.4 1 0 0 1 1 1 0 Poxvirus protein I5 AAA_13 PF13166.1 ESL05502.1 - 3 6.1 17.5 4 5.7 12.1 1.2 1 0 0 1 1 1 0 AAA domain CAF-1_p150 PF11600.3 ESL05502.1 - 3.1 7.1 48.4 4.7 6.5 33.6 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal LMBR1 PF04791.11 ESL05502.1 - 7.4 5.0 11.1 9.8 4.6 7.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Laminin_G_3 PF13385.1 ESL05503.1 - 0.00051 20.3 1.6 0.00057 20.1 1.1 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pkinase PF00069.20 ESL05504.1 - 9.4e-65 218.3 0.0 1.3e-64 217.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05504.1 - 1e-40 139.4 0.0 1.5e-40 138.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05504.1 - 8.4e-09 34.7 0.0 1.3e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL05504.1 - 0.031 14.0 1.2 0.4 10.3 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Actin PF00022.14 ESL05505.1 - 8.3e-148 492.0 0.0 9.7e-148 491.7 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ESL05505.1 - 0.012 16.0 0.1 0.13 12.6 0.0 2.2 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ABC_membrane PF00664.18 ESL05506.1 - 6.2e-52 176.6 24.1 3.7e-29 101.9 4.3 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESL05506.1 - 4.5e-49 166.2 0.0 3.3e-24 85.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESL05506.1 - 3.9e-11 42.5 0.1 0.019 14.1 0.0 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESL05506.1 - 1.7e-10 40.2 0.5 3e-05 23.4 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 ESL05506.1 - 7.8e-10 38.4 0.1 2e-06 27.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.1 ESL05506.1 - 2.3e-09 37.6 0.0 0.0047 16.9 0.0 4.0 4 0 0 4 4 4 2 AAA domain T2SE PF00437.15 ESL05506.1 - 1.6e-07 30.4 0.1 0.0022 16.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_23 PF13476.1 ESL05506.1 - 1.9e-07 31.6 3.8 4.2e-05 23.9 0.0 2.4 3 0 0 3 3 2 2 AAA domain AAA_10 PF12846.2 ESL05506.1 - 2.2e-06 27.3 0.4 0.016 14.6 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain DUF258 PF03193.11 ESL05506.1 - 5.7e-06 25.6 1.1 0.0029 16.8 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 ESL05506.1 - 6.3e-06 26.1 0.1 0.055 13.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_17 PF13207.1 ESL05506.1 - 7.8e-06 26.7 0.0 0.14 12.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESL05506.1 - 9.1e-06 25.7 1.1 0.0041 17.1 0.2 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESL05506.1 - 9.1e-06 25.8 0.1 0.014 15.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain Miro PF08477.8 ESL05506.1 - 1.8e-05 25.2 0.4 0.35 11.3 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_33 PF13671.1 ESL05506.1 - 3e-05 23.9 0.3 0.1 12.4 0.0 3.6 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.13 ESL05506.1 - 3.2e-05 23.5 0.1 0.25 10.8 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family Dynamin_N PF00350.18 ESL05506.1 - 0.00011 22.0 0.1 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.12 ESL05506.1 - 0.0003 20.6 0.8 0.41 10.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function DUF87 MobB PF03205.9 ESL05506.1 - 0.00063 19.4 1.1 0.72 9.5 0.1 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ESL05506.1 - 0.0011 18.6 0.2 0.037 13.7 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 ESL05506.1 - 0.0011 18.5 0.2 1.8 8.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ESL05506.1 - 0.0012 19.1 0.3 1.6 9.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 ESL05506.1 - 0.0028 16.4 0.3 1.6 7.4 0.0 2.3 2 0 0 2 2 2 2 ArgK protein AAA_14 PF13173.1 ESL05506.1 - 0.0036 17.2 0.1 0.11 12.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 ESL05506.1 - 0.0045 16.4 1.4 0.36 10.2 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.4 ESL05506.1 - 0.0046 15.6 0.2 1.2 7.6 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.7 ESL05506.1 - 0.0047 16.6 1.8 0.75 9.4 0.1 2.6 2 0 0 2 2 2 1 NACHT domain ABC_ATPase PF09818.4 ESL05506.1 - 0.0087 14.6 0.2 0.063 11.8 0.1 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class Arch_ATPase PF01637.13 ESL05506.1 - 0.0091 15.7 0.5 0.75 9.4 0.0 2.5 3 0 0 3 3 2 1 Archaeal ATPase AAA_28 PF13521.1 ESL05506.1 - 0.011 15.6 0.6 0.46 10.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.7 ESL05506.1 - 0.018 14.1 0.0 2.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.12 ESL05506.1 - 0.033 13.7 0.4 4.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.17 ESL05506.1 - 0.035 12.9 0.5 2.2 7.0 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain Polyoma_lg_T_C PF06431.6 ESL05506.1 - 0.045 12.4 0.0 0.11 11.1 0.0 1.5 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus Viral_helicase1 PF01443.13 ESL05506.1 - 0.055 12.9 0.0 6.5 6.2 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.12 ESL05506.1 - 0.077 12.4 0.1 3.2 7.1 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Guanylate_kin PF00625.16 ESL05506.1 - 0.078 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Guanylate kinase Adeno_IVa2 PF02456.10 ESL05506.1 - 0.08 11.5 0.1 0.47 9.0 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_15 PF13175.1 ESL05506.1 - 0.15 11.0 0.0 0.7 8.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain DAP3 PF10236.4 ESL05506.1 - 0.19 10.6 1.8 10 4.9 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.17 ESL05506.1 - 0.24 11.6 0.0 14 5.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Pox_A32 PF04665.7 ESL05506.1 - 0.31 10.3 1.3 9.3 5.4 0.1 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein ResIII PF04851.10 ESL05506.1 - 0.42 10.4 0.0 23 4.7 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.11 ESL05506.1 - 0.59 9.3 2.9 2.9 7.0 0.0 2.7 3 0 0 3 3 2 0 PhoH-like protein Pho88 PF10032.4 ESL05507.1 - 2.3e-49 167.2 0.0 2.6e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Kinesin PF00225.18 ESL05508.1 - 1e-79 267.6 0.0 1.7e-79 266.9 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain ATG16 PF08614.6 ESL05508.1 - 0.00035 20.4 1.4 0.00035 20.4 1.0 2.4 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Peptidase_S49_N PF08496.5 ESL05508.1 - 0.23 11.2 2.4 6.1 6.6 1.5 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF607 PF04678.8 ESL05508.1 - 0.81 9.5 5.2 1.8 8.4 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF607 ADIP PF11559.3 ESL05508.1 - 0.91 9.4 15.3 1.6 8.6 4.3 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Seryl_tRNA_N PF02403.17 ESL05508.1 - 1.3 9.1 9.7 1.3 9.0 2.3 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3522 PF12036.3 ESL05509.1 - 1.3e-06 28.3 0.3 1.7e-06 27.9 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3522) Ceramidase PF05875.7 ESL05509.1 - 0.0087 15.2 1.6 0.017 14.2 1.1 1.4 1 0 0 1 1 1 1 Ceramidase AAA_5 PF07728.9 ESL05510.1 - 1.3e-89 297.1 0.0 5.9e-33 113.5 0.0 3.6 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL05510.1 - 2.3e-08 34.2 2.1 0.0024 17.8 0.0 4.1 4 0 0 4 4 3 2 AAA ATPase domain VWA_2 PF13519.1 ESL05510.1 - 3e-07 30.7 0.0 7.8e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_14 PF13173.1 ESL05510.1 - 9.4e-07 28.7 0.0 0.0006 19.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESL05510.1 - 4.2e-06 26.7 0.0 0.053 13.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESL05510.1 - 6.9e-06 26.2 0.0 0.007 16.5 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 ESL05510.1 - 7e-06 25.4 0.0 0.059 12.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_tran PF00005.22 ESL05510.1 - 1.3e-05 25.4 0.1 0.00087 19.5 0.0 3.2 3 0 0 3 3 3 1 ABC transporter AAA_22 PF13401.1 ESL05510.1 - 1.5e-05 25.1 0.6 0.0014 18.7 0.0 3.4 2 1 0 2 2 2 1 AAA domain MCM PF00493.18 ESL05510.1 - 8.8e-05 21.4 0.4 0.097 11.4 0.0 3.4 3 0 0 3 3 3 1 MCM2/3/5 family AAA_17 PF13207.1 ESL05510.1 - 0.00034 21.4 0.0 0.0064 17.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 ESL05510.1 - 0.00056 19.4 0.0 0.012 15.1 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.6 ESL05510.1 - 0.00076 19.0 0.0 0.19 11.3 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESL05510.1 - 0.0025 18.1 0.0 0.022 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 ESL05510.1 - 0.0038 15.9 0.0 0.008 14.9 0.0 1.4 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_28 PF13521.1 ESL05510.1 - 0.0044 16.9 0.0 0.022 14.7 0.0 2.2 2 0 0 2 2 1 1 AAA domain Arch_ATPase PF01637.13 ESL05510.1 - 0.0056 16.4 0.0 0.016 14.9 0.0 1.6 2 0 0 2 2 1 1 Archaeal ATPase VWA PF00092.23 ESL05510.1 - 0.0065 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Mg_chelatase PF01078.16 ESL05510.1 - 0.011 14.9 3.9 0.015 14.4 0.0 3.1 5 0 0 5 5 3 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESL05510.1 - 0.012 15.4 0.0 0.19 11.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.14 ESL05510.1 - 0.013 14.7 0.0 0.1 11.8 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESL05510.1 - 0.019 15.3 0.0 0.05 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 ESL05510.1 - 0.026 14.1 0.1 0.8 9.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 DUF815 PF05673.8 ESL05510.1 - 0.029 13.3 0.0 4.5 6.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) DUF258 PF03193.11 ESL05510.1 - 0.03 13.5 0.0 3.7 6.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 NACHT PF05729.7 ESL05510.1 - 0.04 13.5 0.0 0.22 11.1 0.0 2.4 2 0 0 2 2 1 0 NACHT domain SRP54 PF00448.17 ESL05510.1 - 0.045 13.1 0.2 0.37 10.2 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Arf PF00025.16 ESL05510.1 - 0.061 12.5 0.1 3.3 6.9 0.0 2.9 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA_21 PF13304.1 ESL05510.1 - 0.069 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 ESL05510.1 - 0.08 11.9 0.0 1.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus G-alpha PF00503.15 ESL05510.1 - 0.094 11.3 0.0 0.17 10.4 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit ATP-synt_ab PF00006.20 ESL05510.1 - 0.1 12.1 0.0 0.42 10.0 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.17 ESL05510.1 - 0.13 12.3 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase TIP49 PF06068.8 ESL05510.1 - 0.69 8.5 0.0 2.4 6.8 0.0 1.7 2 0 0 2 2 2 0 TIP49 C-terminus AAA_13 PF13166.1 ESL05510.1 - 5 5.4 0.0 7.7 4.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain Glyco_hydro_47 PF01532.15 ESL05511.1 - 2e-115 386.0 0.0 2.5e-115 385.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Nup54 PF13874.1 ESL05512.1 - 1.2e-31 109.2 0.3 2.4e-31 108.3 0.2 1.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 DUF1875 PF08961.5 ESL05512.1 - 0.00038 19.8 0.1 0.00058 19.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1875) FliJ PF02050.11 ESL05512.1 - 0.0072 16.3 0.5 1.5 8.8 0.0 2.4 2 0 0 2 2 2 2 Flagellar FliJ protein Ribosomal_L1 PF00687.16 ESL05513.1 - 8.4e-33 113.5 2.3 9.2e-33 113.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Antimicrobial_4 PF08024.6 ESL05513.1 - 1.2 9.0 3.6 2.2 8.2 0.4 2.4 2 0 0 2 2 2 0 Ant antimicrobial peptide Pkinase PF00069.20 ESL05514.1 - 6.2e-17 61.5 0.1 7.3e-17 61.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05514.1 - 5.4e-11 42.0 0.1 6.6e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1636 PF07845.6 ESL05514.1 - 0.0055 16.9 0.1 0.015 15.4 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1636) SBDS_C PF09377.5 ESL05515.1 - 1.3e-29 102.4 0.5 2.3e-29 101.6 0.4 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.13 ESL05515.1 - 1.3e-26 92.2 0.3 2.3e-26 91.4 0.2 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein BP28CT PF08146.7 ESL05515.1 - 0.016 14.8 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 BP28CT (NUC211) domain MFS_1 PF07690.11 ESL05516.1 - 3e-18 65.6 34.0 4.1e-15 55.3 15.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05516.1 - 2.2e-10 40.2 19.6 2.2e-10 40.2 13.6 2.7 2 2 0 2 2 2 1 Nodulin-like HlyIII PF03006.15 ESL05516.1 - 0.75 9.1 28.1 0.48 9.7 5.3 3.8 2 2 1 3 3 3 0 Haemolysin-III related HSP33 PF01430.14 ESL05517.1 - 5.1e-07 29.0 0.1 4.4e-05 22.7 0.0 2.2 2 1 0 2 2 2 2 Hsp33 protein BNR_3 PF13859.1 ESL05519.1 - 0.0035 16.4 0.0 0.0044 16.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain DGF-1_5 PF11038.3 ESL05520.1 - 5.9e-38 130.6 8.6 1e-37 129.8 5.9 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05520.1 - 0.048 13.5 0.3 0.089 12.6 0.2 1.4 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus YfhO PF09586.5 ESL05520.1 - 0.15 10.0 0.9 0.18 9.8 0.6 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO PHO4 PF01384.15 ESL05520.1 - 1.8 7.1 4.6 1.2 7.7 1.7 1.6 1 1 0 1 1 1 0 Phosphate transporter family Laminin_G_3 PF13385.1 ESL05522.1 - 1.7e-16 60.8 0.7 3e-16 60.0 0.5 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESL05522.1 - 2.7e-07 30.3 0.9 2.7e-07 30.3 0.6 2.8 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal EGF_alliinase PF04863.8 ESL05522.1 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain SPRY PF00622.23 ESL05523.1 - 2e-10 40.8 0.3 5.8e-08 32.8 0.1 2.9 3 0 0 3 3 3 2 SPRY domain MBT PF02820.13 ESL05523.1 - 0.076 12.9 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 mbt repeat HEAT PF02985.17 ESL05524.1 - 0.0054 16.6 2.4 28 5.1 0.0 5.6 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.2 ESL05524.1 - 0.022 14.6 0.2 0.11 12.2 0.0 2.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 FKBP_C PF00254.23 ESL05525.1 - 2e-09 37.3 0.0 7.1e-09 35.5 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase PCP_red PF08369.5 ESL05525.1 - 0.11 12.3 0.2 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit Thioredoxin_6 PF13848.1 ESL05526.1 - 0.062 13.1 0.0 0.081 12.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Ribosomal_L7Ae PF01248.21 ESL05529.1 - 1.6e-21 75.6 0.4 3e-21 74.7 0.2 1.5 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 ESL05529.1 - 4.6e-05 23.2 0.1 7.4e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 CBFD_NFYB_HMF PF00808.18 ESL05531.1 - 1.8e-05 24.6 0.0 2.6e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ESL05531.1 - 0.017 15.2 0.3 0.036 14.1 0.2 1.7 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 His_binding PF02098.11 ESL05532.1 - 0.012 15.4 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Tick histamine binding protein HECT PF00632.20 ESL05533.1 - 2.9e-55 187.6 0.0 5.9e-55 186.6 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESL05533.1 - 1.6e-42 144.4 1.6 3.3e-18 65.9 0.0 4.0 3 1 0 3 3 3 3 SPRY domain Laminin_G_3 PF13385.1 ESL05533.1 - 2.5e-21 76.5 0.0 3e-09 37.2 0.0 3.1 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily UBA PF00627.26 ESL05533.1 - 0.037 13.8 0.2 0.094 12.5 0.1 1.7 1 0 0 1 1 1 0 UBA/TS-N domain TRAPPC-Trs85 PF12739.2 ESL05534.1 - 5.1e-49 167.0 0.2 8.7e-49 166.2 0.2 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_11 PF13414.1 ESL05534.1 - 0.076 12.6 2.6 1.4 8.6 0.0 2.6 2 0 0 2 2 2 0 TPR repeat TPR_12 PF13424.1 ESL05534.1 - 0.14 12.1 3.0 2.2 8.2 0.1 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL05534.1 - 0.28 11.0 1.6 15 5.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TRAPPC9-Trs120 PF08626.6 ESL05534.1 - 0.7 7.1 0.0 1.5 6.0 0.0 1.4 2 0 0 2 2 2 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit HSP70 PF00012.15 ESL05535.1 - 1.5e-190 634.1 0.2 1.8e-190 633.9 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL05535.1 - 1.4e-18 66.6 0.1 1.9e-18 66.1 0.1 1.2 1 0 0 1 1 1 1 MreB/Mbl protein DDR PF08841.5 ESL05535.1 - 0.017 13.9 0.5 3.1 6.5 0.2 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.6 ESL05535.1 - 0.023 13.6 0.1 0.085 11.7 0.0 1.8 1 1 0 2 2 2 0 StbA protein DUF1464 PF07318.7 ESL05535.1 - 0.033 12.9 0.0 0.057 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) DUF3094 PF11293.3 ESL05537.1 - 0.0046 16.3 0.1 0.0081 15.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3094) Peptidase_M8 PF01457.11 ESL05537.1 - 0.014 13.7 0.0 0.016 13.5 0.0 1.1 1 0 0 1 1 1 0 Leishmanolysin PsiA PF06952.6 ESL05537.1 - 0.14 11.1 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 PsiA protein Tubulin PF00091.20 ESL05538.1 - 2.1e-45 155.2 0.0 2.9e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.1 ESL05538.1 - 0.012 14.5 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 Tubulin like ArfGap PF01412.13 ESL05539.1 - 7e-37 125.7 1.0 7e-37 125.7 0.7 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf DnaJ PF00226.26 ESL05541.1 - 1.1e-21 76.2 0.0 2.5e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESL05541.1 - 9.9e-11 41.2 0.2 2e-09 37.0 0.0 2.2 1 1 1 2 2 2 1 X-domain of DnaJ-containing DUF3487 PF11990.3 ESL05541.1 - 0.81 9.1 3.4 1.3 8.4 1.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3487) EF-hand_7 PF13499.1 ESL05542.1 - 3.5e-09 36.6 0.7 7e-08 32.4 0.2 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL05542.1 - 0.0001 21.8 2.1 0.04 13.5 0.1 3.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL05542.1 - 0.00014 20.9 5.8 0.01 15.0 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 ESL05542.1 - 0.018 14.8 5.6 0.063 13.2 0.0 3.7 4 0 0 4 4 4 0 EF-hand domain EF-hand_5 PF13202.1 ESL05542.1 - 0.027 13.8 0.8 0.069 12.5 0.0 2.1 2 0 0 2 2 2 0 EF hand Aa_trans PF01490.13 ESL05544.1 - 3.4e-49 167.4 29.0 3.9e-49 167.2 20.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL05544.1 - 3.5e-12 45.8 11.4 3.5e-12 45.8 7.9 2.2 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESL05544.1 - 5.1e-07 28.5 19.1 5.1e-07 28.5 13.3 2.1 2 0 0 2 2 2 1 Amino acid permease HSP70 PF00012.15 ESL05545.1 - 4.2e-113 378.3 1.2 4.6e-113 378.2 0.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL05545.1 - 5.7e-13 48.1 0.0 6.7e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 MreB/Mbl protein DDR PF08841.5 ESL05545.1 - 0.0059 15.4 0.4 0.7 8.6 0.1 2.2 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain StbA PF06406.6 ESL05545.1 - 0.055 12.4 0.1 0.083 11.8 0.1 1.4 1 1 0 1 1 1 0 StbA protein Glycos_transf_2 PF00535.21 ESL05546.1 - 0.00059 19.5 0.0 0.0008 19.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 UIM PF02809.15 ESL05546.1 - 0.54 9.9 4.7 0.8 9.4 0.9 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Flagellar_rod PF05149.7 ESL05547.1 - 4.6e-100 334.5 20.4 6e-100 334.1 14.1 1.2 1 0 0 1 1 1 1 Paraflagellar rod protein Sipho_Gp157 PF05565.6 ESL05547.1 - 0.011 15.3 2.3 0.011 15.3 1.6 2.4 2 1 1 3 3 3 0 Siphovirus Gp157 SpoIISA_toxin PF14171.1 ESL05547.1 - 0.02 14.1 1.0 0.054 12.7 0.7 1.6 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system DDE_Tnp_1 PF01609.16 ESL05547.1 - 0.42 10.1 3.5 0.88 9.0 2.4 1.7 1 1 0 1 1 1 0 Transposase DDE domain DUF883 PF05957.8 ESL05547.1 - 6.3 7.2 17.0 2.5 8.5 0.2 3.7 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF883) HECT PF00632.20 ESL05548.1 - 6.7e-44 150.3 0.1 1.2e-43 149.5 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESL05548.1 - 0.00017 21.6 0.0 0.31 11.1 0.0 3.7 3 0 0 3 3 3 1 SPRY domain MA-Mit PF09245.5 ESL05548.1 - 4 6.6 0.0 7.9 5.6 0.0 1.3 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen BNR_3 PF13859.1 ESL05549.1 - 2e-31 109.2 0.0 2.7e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05549.1 - 0.00049 19.4 0.0 0.0027 17.0 0.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Mucin PF01456.12 ESL05550.1 - 1.5e-21 76.6 56.1 1.5e-21 76.6 38.9 2.5 2 0 0 2 2 2 1 Mucin-like glycoprotein Otopetrin PF03189.8 ESL05550.1 - 0.0097 14.9 0.3 0.012 14.6 0.2 1.2 1 0 0 1 1 1 1 Otopetrin UPF0114 PF03350.11 ESL05550.1 - 0.13 12.1 2.7 2.4 8.1 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized protein family, UPF0114 DUF812 PF05667.6 ESL05550.1 - 0.15 10.5 7.1 0.18 10.2 4.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) PAP1 PF08601.5 ESL05550.1 - 1 9.0 12.8 1.2 8.7 8.8 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 DUF2413 PF10310.4 ESL05550.1 - 2.8 6.6 10.8 3.7 6.2 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Glyco_transf_22 PF03901.12 ESL05550.1 - 3 6.7 13.1 4.2 6.2 9.1 1.2 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family Zip PF02535.17 ESL05551.1 - 1.4e-36 126.0 20.6 1.4e-36 126.0 14.3 2.3 2 1 0 2 2 2 1 ZIP Zinc transporter DUF2796 PF10986.3 ESL05551.1 - 1.1 9.2 11.8 2.2 8.2 8.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) HSP90 PF00183.13 ESL05552.1 - 2.5e-262 871.0 32.5 2.9e-262 870.8 22.5 1.0 1 0 0 1 1 1 1 Hsp90 protein DUF1510 PF07423.6 ESL05552.1 - 0.0078 15.5 12.6 0.0078 15.5 8.8 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) LOH1CR12 PF10158.4 ESL05552.1 - 0.023 14.4 0.4 0.071 12.9 0.3 1.8 1 0 0 1 1 1 0 Tumour suppressor protein Flagellar_rod PF05149.7 ESL05554.1 - 1.2e-108 362.7 33.1 1.2e-108 362.7 23.0 3.0 2 1 1 3 3 3 2 Paraflagellar rod protein WD40 PF00400.27 ESL05555.1 - 0.0012 18.6 0.0 1.6 8.7 0.0 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat CHAP PF05257.11 ESL05558.1 - 1.1e-07 31.5 0.7 1.1e-06 28.2 0.1 2.0 2 0 0 2 2 2 1 CHAP domain 2-Hacid_dh_C PF02826.14 ESL05559.1 - 8.2e-43 145.6 0.0 1.1e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESL05559.1 - 1.2e-06 28.0 0.0 1.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_10 PF13460.1 ESL05559.1 - 5.3e-05 23.3 0.0 7.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 ESL05559.1 - 0.00011 22.1 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESL05559.1 - 0.00039 20.2 0.1 0.00056 19.7 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESL05559.1 - 0.0013 19.0 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 ESL05559.1 - 0.0027 17.5 0.1 0.0081 16.0 0.0 1.8 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.14 ESL05559.1 - 0.0046 15.6 0.0 0.0065 15.1 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.16 ESL05559.1 - 0.011 15.2 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Saccharop_dh PF03435.13 ESL05559.1 - 0.017 14.1 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase XdhC_C PF13478.1 ESL05559.1 - 0.028 14.7 0.0 0.043 14.1 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain NAD_binding_7 PF13241.1 ESL05559.1 - 0.034 14.3 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Gp_dh_N PF00044.19 ESL05559.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESL05559.1 - 0.089 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peptidase_M20 PF01546.23 ESL05560.1 - 2.1e-24 86.0 0.0 2.7e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL05560.1 - 4.5e-18 65.0 0.0 6.6e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain zf-PHD-like PF15446.1 ESL05560.1 - 0.076 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Pkinase PF00069.20 ESL05561.1 - 4.2e-69 232.5 0.0 4.8e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05561.1 - 3.1e-32 111.6 0.0 3.9e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05561.1 - 0.0001 21.3 0.0 0.00015 20.8 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.19 ESL05561.1 - 0.066 13.7 0.1 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain CTP_synth_N PF06418.9 ESL05562.1 - 9.4e-81 270.9 0.0 1.3e-80 270.4 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 ESL05562.1 - 4.5e-36 124.1 0.0 9.1e-36 123.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESL05562.1 - 5.9e-08 32.4 0.1 1.8e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Peptidase C26 DHO_dh PF01180.16 ESL05563.1 - 1.1e-69 234.6 0.0 1.3e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 ESL05563.1 - 0.0032 16.3 0.0 0.15 10.8 0.0 2.2 2 0 0 2 2 2 2 FMN-dependent dehydrogenase PcrB PF01884.12 ESL05563.1 - 0.021 14.1 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 PcrB family F_bP_aldolase PF01116.15 ESL05563.1 - 0.17 10.9 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II ELO PF01151.13 ESL05564.1 - 4.9e-41 140.6 15.4 6.9e-41 140.1 10.7 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family 5TM-5TMR_LYT PF07694.7 ESL05564.1 - 0.078 12.3 4.9 0.1 11.8 0.6 2.2 2 0 0 2 2 2 0 5TMR of 5TMR-LYT Lipase_3 PF01764.20 ESL05565.1 - 1.6e-29 102.3 0.0 2.9e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) MIG-14_Wnt-bd PF06664.7 ESL05565.1 - 2.2e-05 23.4 8.0 2.2e-05 23.4 5.5 2.9 2 1 1 3 3 3 1 Wnt-binding factor required for Wnt secretion CT47 PF15623.1 ESL05565.1 - 0.0082 15.9 2.9 0.014 15.1 2.0 1.3 1 0 0 1 1 1 1 Cancer/testis gene family 47 DUF2974 PF11187.3 ESL05565.1 - 0.011 15.0 0.0 0.094 12.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Ribosomal_60s PF00428.14 ESL05565.1 - 3.9 7.9 8.5 1.9 8.9 1.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein LCM PF04072.9 ESL05567.1 - 1.2e-25 90.1 0.0 1.7e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase PGM_PMM_I PF02878.11 ESL05567.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Peptidase_M8 PF01457.11 ESL05568.1 - 2.2e-91 306.7 1.5 8e-91 304.9 1.0 1.7 1 1 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESL05568.1 - 0.016 15.1 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF3810 PF12725.2 ESL05568.1 - 0.088 11.6 0.2 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) BNR_3 PF13859.1 ESL05570.1 - 2.3e-07 30.1 0.2 3.1e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Internalin_N PF12354.3 ESL05570.1 - 0.069 12.7 0.2 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal DUF2933 PF11666.3 ESL05570.1 - 3.2 7.3 0.0 3.2 7.3 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2933) RepA1_leader PF08048.7 ESL05570.1 - 8.5 6.5 9.5 5.3 7.1 2.3 2.5 2 0 0 2 2 2 0 Tap RepA1 leader peptide Ribosomal_L2_C PF03947.13 ESL05571.1 - 9.5e-41 138.6 1.3 2.4e-40 137.3 1.0 1.5 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 ESL05571.1 - 6.1e-09 35.7 0.0 1.6e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Colicin PF01024.14 ESL05572.1 - 0.12 11.9 11.5 0.5 9.9 0.3 2.8 3 0 0 3 3 3 0 Colicin pore forming domain Baculo_PEP_C PF04513.7 ESL05572.1 - 0.99 9.2 11.9 3.3 7.5 0.2 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ESL05572.1 - 2.9 7.8 6.4 18 5.2 0.7 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BNR_3 PF13859.1 ESL05573.1 - 1.4e-40 139.3 0.0 1.8e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05573.1 - 0.00086 18.6 0.0 0.0016 17.7 0.0 1.5 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESL05573.1 - 0.0063 16.1 0.1 0.32 10.9 0.0 2.8 2 0 0 2 2 2 1 BNR/Asp-box repeat JAB PF01398.16 ESL05574.1 - 3.6e-13 49.2 0.0 7.3e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESL05574.1 - 0.00071 19.1 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain WW PF00397.21 ESL05575.1 - 1.5e-13 50.3 7.8 2.4e-06 27.2 0.2 2.5 2 0 0 2 2 2 2 WW domain MFS_1 PF07690.11 ESL05576.1 - 4.7e-13 48.5 43.4 8.8e-11 41.1 16.0 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05576.1 - 0.00023 20.4 18.0 0.0053 16.0 12.5 2.3 1 1 0 1 1 1 1 Nodulin-like OTU PF02338.14 ESL05577.1 - 2.8e-15 56.9 0.1 4.8e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Mito_carr PF00153.22 ESL05578.1 - 1.1e-52 175.7 1.6 2.7e-20 71.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1632 PF07857.7 ESL05578.1 - 0.032 13.4 0.0 0.069 12.4 0.0 1.5 1 0 0 1 1 1 0 CEO family (DUF1632) GTP_EFTU PF00009.22 ESL05580.1 - 5.9e-55 185.6 0.0 1e-54 184.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL05580.1 - 5.2e-36 122.7 0.1 3.1e-35 120.3 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL05580.1 - 7.5e-18 64.4 0.6 7.5e-18 64.4 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 ESL05580.1 - 1.1e-05 24.9 0.1 4.3e-05 23.0 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 ESL05580.1 - 2.1e-05 24.4 0.0 0.00052 19.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL05580.1 - 0.0023 18.3 0.2 0.068 13.6 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL05580.1 - 0.024 13.8 0.0 0.055 12.6 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Semialdhyde_dhC PF02774.13 ESL05580.1 - 0.025 14.4 0.1 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Dynamin_N PF00350.18 ESL05580.1 - 0.11 12.3 0.0 16 5.2 0.0 2.5 2 0 0 2 2 2 0 Dynamin family TPR_12 PF13424.1 ESL05581.1 - 4.9e-08 32.7 15.5 0.00016 21.5 1.4 6.6 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESL05581.1 - 1.2e-05 25.4 15.3 2.8 8.8 0.1 7.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESL05581.1 - 1.8e-05 24.3 14.7 0.27 10.8 0.1 5.8 6 0 0 6 6 6 3 TPR repeat TPR_2 PF07719.12 ESL05581.1 - 2.4e-05 23.9 19.3 0.83 9.7 0.8 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL05581.1 - 5.1e-05 23.5 18.3 0.059 13.7 0.4 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat Apc3 PF12895.2 ESL05581.1 - 0.00083 19.4 14.0 0.0052 16.8 0.2 5.0 4 2 1 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESL05581.1 - 0.00084 18.9 15.9 0.35 10.7 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.9 ESL05581.1 - 0.0011 19.1 7.2 2.5 8.7 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL05581.1 - 0.12 13.0 19.5 0.86 10.3 1.9 6.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL05581.1 - 0.16 11.6 16.5 2.7 7.7 0.6 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL05581.1 - 1.9 8.5 9.0 18 5.4 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL05581.1 - 5.8 6.9 16.1 13 5.8 0.2 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat BSMAP PF12280.3 ESL05582.1 - 0.028 14.3 1.6 0.036 13.9 1.1 1.2 1 0 0 1 1 1 0 Brain specific membrane anchored protein DGF-1_5 PF11038.3 ESL05583.1 - 1.6e-139 463.8 17.2 2.3e-139 463.3 11.9 1.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05583.1 - 6e-22 77.3 0.2 1.8e-21 75.7 0.1 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4227 PF14004.1 ESL05583.1 - 0.0087 15.8 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4227) Tubulin PF00091.20 ESL05584.1 - 8e-72 241.5 0.0 1.1e-71 241.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESL05584.1 - 5.1e-14 52.4 0.1 7.9e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESL05584.1 - 2.3e-05 24.4 0.0 3.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESL05584.1 - 0.0011 18.5 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Ribosomal_S13 PF00416.17 ESL05585.1 - 6.4e-23 81.2 0.4 7.4e-23 81.0 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 DNA_pol_A PF00476.15 ESL05588.1 - 1.1e-34 119.7 0.0 2.1e-34 118.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A Helicase_C PF00271.26 ESL05589.1 - 8.1e-15 54.4 0.0 8.9e-14 51.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL05589.1 - 1.3e-13 50.7 0.0 3.3e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase HRDC PF00570.18 ESL05589.1 - 1.3e-07 31.1 0.0 2.4e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 HRDC domain CNH PF00780.17 ESL05591.1 - 8.1e-08 32.0 0.0 1.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 CNH domain Glyco_hydro_63 PF03200.11 ESL05592.1 - 2.5e-26 91.8 0.4 1.1e-12 46.6 0.0 2.0 1 1 1 2 2 2 2 Mannosyl oligosaccharide glucosidase Aminotran_5 PF00266.14 ESL05593.1 - 1.4e-11 43.8 0.0 1.9e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V YadA_anchor PF03895.10 ESL05595.1 - 0.16 12.0 2.3 0.66 10.0 0.2 2.8 2 0 0 2 2 2 0 YadA-like C-terminal region MMR_HSR1 PF01926.18 ESL05596.1 - 3.1e-17 62.5 0.1 3.8e-14 52.6 0.0 2.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL05596.1 - 1.2e-06 27.9 0.0 4.6e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.11 ESL05596.1 - 0.00012 21.2 0.0 0.00026 20.1 0.0 1.5 1 0 0 1 1 1 1 AIG1 family DUF258 PF03193.11 ESL05596.1 - 0.031 13.4 0.2 0.15 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Miro PF08477.8 ESL05596.1 - 0.055 13.9 0.0 0.26 11.7 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein Dynamin_N PF00350.18 ESL05596.1 - 4.7 6.9 6.3 0.73 9.6 0.1 2.8 3 1 0 3 3 3 0 Dynamin family PIP5K PF01504.13 ESL05597.1 - 9.5e-61 205.0 0.0 1.4e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase RabGAP-TBC PF00566.13 ESL05598.1 - 6e-10 38.9 0.9 9.2e-10 38.3 0.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF1G PF00647.14 ESL05599.1 - 1.6e-47 159.6 0.0 6.8e-47 157.6 0.1 1.9 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 ESL05599.1 - 9.6e-15 54.3 0.7 1.9e-14 53.3 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESL05599.1 - 6.7e-11 42.2 0.0 1.7e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESL05599.1 - 1.8e-06 28.3 1.0 3.1e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESL05599.1 - 3.2e-06 27.2 0.0 6.9e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESL05599.1 - 2.7e-05 23.9 0.3 2.7e-05 23.9 0.2 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESL05599.1 - 0.0064 16.4 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF3487 PF11990.3 ESL05600.1 - 0.0075 15.6 2.4 0.016 14.5 0.6 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3487) Peptidase_M8 PF01457.11 ESL05601.1 - 6.2e-123 410.8 0.1 7.8e-123 410.5 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESL05601.1 - 0.0078 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.1 ESL05601.1 - 0.014 15.9 0.0 0.031 14.8 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.3 ESL05601.1 - 0.047 13.0 0.0 0.076 12.3 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.19 ESL05601.1 - 0.091 12.1 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.1 ESL05601.1 - 0.13 11.7 0.0 0.77 9.2 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF4457 PF14652.1 ESL05601.1 - 0.33 9.8 0.0 0.5 9.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) SNARE PF05739.14 ESL05602.1 - 1.1e-18 66.5 0.8 1.1e-18 66.5 0.6 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESL05602.1 - 0.0017 18.4 1.5 0.0017 18.4 1.1 2.1 2 0 0 2 2 2 1 Syntaxin Syntaxin-6_N PF09177.6 ESL05602.1 - 1.9 8.9 8.6 0.46 10.9 1.7 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.7 ESL05602.1 - 2.8 7.7 6.3 5.3 6.8 0.2 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Ribosomal_L4 PF00573.17 ESL05603.1 - 3.9e-25 88.3 0.0 6.3e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 ESL05603.1 - 2.5e-14 52.9 7.2 2.7e-14 52.7 3.7 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Pkinase PF00069.20 ESL05604.1 - 2.8e-40 138.1 0.0 3.7e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05604.1 - 2.5e-14 52.9 0.0 3.8e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL05604.1 - 0.00097 18.9 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESL05604.1 - 0.083 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESL05604.1 - 0.17 10.8 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ribosomal_L37ae PF01780.14 ESL05605.1 - 2e-36 123.6 5.0 2.2e-36 123.5 3.4 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family C1_1 PF00130.17 ESL05605.1 - 0.0022 17.7 2.5 0.0032 17.1 1.7 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.5 ESL05605.1 - 0.0062 15.9 0.7 1.8 8.1 0.0 2.1 2 0 0 2 2 2 2 A2L zinc ribbon domain Carla_C4 PF01623.12 ESL05605.1 - 0.079 12.7 1.2 0.096 12.4 0.9 1.3 1 1 0 1 1 1 0 Carlavirus putative nucleic acid binding protein NOB1_Zn_bind PF08772.6 ESL05605.1 - 0.11 12.3 4.2 1.3 8.8 2.9 2.2 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Zn_Tnp_IS1595 PF12760.2 ESL05605.1 - 0.11 12.2 2.5 0.17 11.6 1.7 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.8 ESL05605.1 - 6.2 6.4 6.9 1.2 8.7 2.1 1.8 2 0 0 2 2 2 0 ClpX C4-type zinc finger GTP_EFTU_D3 PF03143.12 ESL05607.1 - 2.6e-36 123.7 0.1 1.9e-35 120.9 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.22 ESL05607.1 - 2.1e-19 69.7 0.0 4e-19 68.7 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 ESL05607.1 - 5e-18 64.9 0.6 5e-18 64.9 0.4 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 ESL05607.1 - 1e-05 25.0 0.4 2.8e-05 23.6 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.13 ESL05607.1 - 0.012 15.4 0.2 0.21 11.4 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Kelch_6 PF13964.1 ESL05608.1 - 2.8e-09 36.7 0.5 0.00052 20.0 0.0 4.5 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 ESL05608.1 - 3.8e-07 29.9 0.0 0.012 15.5 0.0 4.0 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 ESL05608.1 - 6.3e-05 22.4 0.1 0.082 12.4 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 ESL05608.1 - 0.011 15.5 3.5 0.37 10.6 0.0 4.5 5 0 0 5 5 5 0 Kelch motif Galactosyl_T PF01762.16 ESL05609.1 - 5.7e-09 35.8 0.3 0.0011 18.6 0.1 3.3 3 1 0 3 3 3 2 Galactosyltransferase Aminotran_1_2 PF00155.16 ESL05610.1 - 2.7e-45 154.8 0.0 3.4e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II MPC PF03650.8 ESL05610.1 - 0.091 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0041) PI3_PI4_kinase PF00454.22 ESL05611.1 - 0.02 14.3 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase AAA_12 PF13087.1 ESL05612.1 - 3.2e-52 176.8 0.0 5.4e-52 176.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESL05612.1 - 2.2e-45 155.0 0.8 1.7e-44 152.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESL05612.1 - 2.9e-10 40.0 0.9 0.00017 21.2 0.4 3.1 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.1 ESL05612.1 - 7.1e-10 38.5 4.2 8.3e-10 38.2 0.1 3.3 4 0 0 4 4 4 1 Part of AAA domain UvrD-helicase PF00580.16 ESL05612.1 - 7.9e-05 22.0 0.0 0.0058 15.9 0.0 2.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain ResIII PF04851.10 ESL05612.1 - 0.002 17.9 0.0 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESL05612.1 - 0.0089 16.1 0.0 0.13 12.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 ESL05612.1 - 0.034 13.1 0.1 4.7 6.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SH3_1 PF00018.23 ESL05613.1 - 6.5e-09 35.0 0.0 1.2e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESL05613.1 - 2e-08 33.6 0.0 3.5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 ESL05613.1 - 2.1e-07 30.4 0.0 3.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TBPIP PF07106.8 ESL05613.1 - 0.031 13.8 13.0 0.56 9.7 0.4 3.0 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1664 PF07889.7 ESL05613.1 - 0.051 13.3 2.7 8.3 6.2 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) APG6 PF04111.7 ESL05613.1 - 0.16 11.0 11.5 0.12 11.3 0.2 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 FlaC_arch PF05377.6 ESL05613.1 - 0.28 11.1 3.9 18 5.3 0.1 3.7 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.15 ESL05613.1 - 0.85 9.4 11.5 10 5.9 0.0 3.7 3 1 0 3 3 3 0 Prefoldin subunit DUF342 PF03961.8 ESL05613.1 - 2.9 6.1 4.3 3.4 5.9 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Adeno_PIX PF03955.9 ESL05613.1 - 6.9 7.2 5.6 7.3 7.1 0.3 2.9 3 0 0 3 3 3 0 Adenovirus hexon-associated protein (IX) Jnk-SapK_ap_N PF09744.4 ESL05613.1 - 9 6.2 15.2 1.5 8.8 0.7 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FYVE PF01363.16 ESL05617.1 - 6e-14 51.6 16.3 1.2e-13 50.7 11.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 ESL05617.1 - 5.9 6.8 19.3 5.4 6.9 10.3 2.8 1 1 1 2 2 2 0 FYVE-type zinc finger MFS_1 PF07690.11 ESL05618.1 - 9.6e-19 67.2 33.0 5.8e-16 58.1 15.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05618.1 - 2.5e-11 43.3 20.1 2.5e-11 43.3 13.9 2.6 2 2 0 2 2 2 1 Nodulin-like EF-hand_1 PF00036.27 ESL05619.1 - 2.1e-29 98.5 13.0 0.00018 20.5 0.1 9.9 10 0 0 10 10 10 6 EF hand EF-hand_7 PF13499.1 ESL05619.1 - 4e-29 100.5 19.7 1.9e-08 34.3 1.3 6.3 5 2 1 6 6 6 3 EF-hand domain pair EF-hand_6 PF13405.1 ESL05619.1 - 3.5e-21 73.1 20.2 0.00026 20.5 0.1 9.2 10 0 0 10 10 10 6 EF-hand domain EF-hand_8 PF13833.1 ESL05619.1 - 1.5e-20 72.5 12.1 0.1 12.2 0.0 9.3 8 1 1 9 9 9 6 EF-hand domain pair EF-hand_5 PF13202.1 ESL05619.1 - 9.2e-18 62.7 7.7 2.5e-05 23.3 0.2 6.2 6 0 0 6 6 6 4 EF hand SPARC_Ca_bdg PF10591.4 ESL05619.1 - 3.8e-05 23.6 1.3 0.51 10.3 0.1 4.3 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region Excalibur PF05901.6 ESL05619.1 - 0.01 16.1 2.0 6.9 7.1 0.0 3.9 4 0 0 4 4 4 0 Excalibur calcium-binding domain Brix PF04427.13 ESL05619.1 - 0.085 12.4 0.0 0.23 11.0 0.0 1.7 1 1 0 1 1 1 0 Brix domain Reo_sigmaC PF04582.7 ESL05620.1 - 0.38 9.8 15.7 1.5 7.8 0.1 5.1 2 1 3 6 6 6 0 Reovirus sigma C capsid protein DUF948 PF06103.6 ESL05620.1 - 6.9 6.6 13.0 64 3.5 0.1 5.1 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) RabGAP-TBC PF00566.13 ESL05621.1 - 1.7e-36 125.7 0.0 2.4e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TPR_11 PF13414.1 ESL05622.1 - 1.5e-27 95.0 19.8 3.4e-11 42.6 2.3 6.7 4 2 1 6 6 6 6 TPR repeat TPR_12 PF13424.1 ESL05622.1 - 1.5e-27 95.2 21.5 7.7e-08 32.1 0.8 7.5 4 3 3 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.12 ESL05622.1 - 3.5e-19 67.1 26.5 0.0063 16.3 0.0 10.4 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESL05622.1 - 1e-18 67.4 11.1 1.3e-05 25.6 0.1 6.6 4 2 3 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESL05622.1 - 4.6e-17 60.8 31.2 0.00039 19.9 0.0 9.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.1 ESL05622.1 - 1.3e-15 56.4 2.9 0.54 11.0 0.0 9.7 4 3 6 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESL05622.1 - 1.1e-14 54.5 11.7 0.00094 19.4 0.2 6.7 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.1 ESL05622.1 - 1.2e-14 53.6 12.7 0.0067 16.8 0.0 9.4 11 0 0 11 11 11 3 Tetratricopeptide repeat Apc3 PF12895.2 ESL05622.1 - 1.8e-11 43.9 21.0 0.00019 21.5 0.1 6.2 4 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESL05622.1 - 2.8e-11 42.3 15.7 0.3 11.0 0.0 9.0 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL05622.1 - 8.9e-11 40.7 28.3 0.071 12.9 0.1 9.3 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_10 PF13374.1 ESL05622.1 - 3.3e-09 36.3 11.9 0.3 11.0 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESL05622.1 - 4.8e-09 35.6 9.2 0.064 13.4 0.6 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat PPR PF01535.15 ESL05622.1 - 0.00032 20.4 6.8 2 8.5 0.0 5.8 6 0 0 6 6 6 2 PPR repeat TPR_21 PF09976.4 ESL05622.1 - 0.00054 19.9 1.8 0.003 17.4 0.4 2.8 3 1 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL05622.1 - 0.068 13.0 15.4 8 6.4 0.1 6.8 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat FERM_M PF00373.13 ESL05623.1 - 9.2e-18 64.6 0.0 2e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 FERM central domain LRR_4 PF12799.2 ESL05623.1 - 2e-12 46.4 0.0 0.21 11.2 0.0 7.1 3 2 6 9 9 9 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL05623.1 - 3.1e-11 41.6 1.0 25 5.3 0.0 9.7 11 0 0 11 11 11 0 Leucine Rich Repeat LRR_6 PF13516.1 ESL05623.1 - 4.4e-10 38.5 2.9 5.2 7.4 0.0 8.9 11 0 0 11 11 11 2 Leucine Rich repeat FERM_N PF09379.5 ESL05623.1 - 6.5e-08 32.5 0.0 1.2e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain LRR_7 PF13504.1 ESL05623.1 - 2.7e-05 23.6 11.6 30 5.4 0.0 9.8 12 0 0 12 12 12 0 Leucine rich repeat LRR_8 PF13855.1 ESL05623.1 - 0.00052 19.7 3.9 1.4 8.6 0.1 5.5 3 2 3 6 6 6 2 Leucine rich repeat Gluconate_2-dh3 PF13618.1 ESL05623.1 - 0.28 11.3 2.4 20 5.3 0.0 2.7 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 YliH PF10799.3 ESL05623.1 - 0.67 9.6 3.7 4.8 6.8 0.3 3.1 3 0 0 3 3 3 0 Biofilm formation protein (YliH/bssR) Chorein_N PF12624.2 ESL05624.1 - 1.4e-17 63.2 0.0 3.1e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter ATP-synt_ab PF00006.20 ESL05625.1 - 1.7e-69 233.5 0.1 2.7e-69 232.9 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL05625.1 - 0.017 15.5 0.0 0.042 14.3 0.0 1.7 1 0 0 1 1 1 0 ATP synthase alpha/beta chain, C terminal domain PGAP1 PF07819.8 ESL05626.1 - 4.4e-21 75.4 0.0 6.6e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 ESL05626.1 - 1e-05 25.5 0.1 1.8e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL05626.1 - 1.2e-05 25.1 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 ESL05626.1 - 5.5e-05 22.7 0.1 0.00018 21.1 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) DUF676 PF05057.9 ESL05626.1 - 0.00015 21.1 0.1 0.00037 19.8 0.1 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) DUF900 PF05990.7 ESL05626.1 - 0.01 15.1 0.1 0.04 13.2 0.1 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Thioesterase PF00975.15 ESL05626.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain DUF2048 PF09752.4 ESL05626.1 - 0.095 11.5 0.1 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Mnd1 PF03962.10 ESL05627.1 - 0.0023 17.6 24.7 0.12 12.0 3.2 2.3 2 1 0 2 2 2 2 Mnd1 family DUF1843 PF08898.5 ESL05627.1 - 0.0047 16.9 9.6 0.044 13.8 0.5 4.0 3 1 0 3 3 3 1 Domain of unknown function (DUF1843) TPR_MLP1_2 PF07926.7 ESL05627.1 - 0.0064 16.2 5.2 0.0064 16.2 3.6 3.7 1 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.7 ESL05627.1 - 0.018 14.2 10.6 0.039 13.1 2.6 2.5 1 1 2 3 3 3 0 Reovirus sigma C capsid protein YlqD PF11068.3 ESL05627.1 - 0.019 15.0 24.9 0.21 11.6 4.2 3.2 2 1 1 3 3 3 0 YlqD protein DUF972 PF06156.8 ESL05627.1 - 0.022 15.1 25.3 0.79 10.0 3.9 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF972) RPA_interact_C PF14768.1 ESL05627.1 - 0.052 13.9 3.0 0.31 11.4 0.1 2.6 2 1 0 2 2 2 0 Replication protein A interacting C-terminal COMPASS-Shg1 PF05205.7 ESL05627.1 - 0.065 13.5 1.0 0.065 13.5 0.7 2.6 3 1 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 Filament PF00038.16 ESL05627.1 - 0.11 11.9 29.9 12 5.2 20.6 3.3 1 1 0 1 1 1 0 Intermediate filament protein DUF4407 PF14362.1 ESL05627.1 - 0.2 10.5 22.6 0.6 9.0 5.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.6 ESL05627.1 - 0.23 11.3 8.2 16 5.4 0.6 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) APG6 PF04111.7 ESL05627.1 - 0.25 10.3 30.4 0.39 9.7 4.3 2.4 1 1 2 3 3 3 0 Autophagy protein Apg6 TMF_TATA_bd PF12325.3 ESL05627.1 - 0.3 10.8 32.6 0.025 14.3 5.0 4.2 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 ESL05627.1 - 0.31 10.8 25.5 0.9 9.3 1.1 4.7 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.4 ESL05627.1 - 0.5 10.5 16.0 0.17 12.0 0.3 3.8 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.15 ESL05627.1 - 0.5 10.1 23.8 0.58 9.9 2.3 4.3 2 1 1 3 3 3 0 Prefoldin subunit Leu_zip PF15294.1 ESL05627.1 - 0.54 9.3 25.0 0.047 12.8 7.1 2.7 1 1 0 2 2 2 0 Leucine zipper Seryl_tRNA_N PF02403.17 ESL05627.1 - 0.61 10.1 21.9 1.1 9.2 2.8 3.7 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Fib_alpha PF08702.5 ESL05627.1 - 1.4 9.0 19.1 2.6 8.1 2.2 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Ax_dynein_light PF10211.4 ESL05627.1 - 1.4 8.6 25.3 0.64 9.8 2.3 3.2 1 1 1 3 3 3 0 Axonemal dynein light chain DivIVA PF05103.8 ESL05627.1 - 1.7 8.7 27.3 2.5 8.1 3.5 3.5 1 1 2 3 3 3 0 DivIVA protein HALZ PF02183.13 ESL05627.1 - 1.9 8.2 22.2 0.36 10.5 0.8 5.9 6 0 0 6 6 6 0 Homeobox associated leucine zipper IncA PF04156.9 ESL05627.1 - 2.5 7.6 40.2 1 8.9 7.9 3.0 1 1 2 3 3 3 0 IncA protein HOOK PF05622.7 ESL05627.1 - 2.6 5.7 31.8 5.6 4.6 22.1 1.5 1 1 0 1 1 1 0 HOOK protein Baculo_PEP_C PF04513.7 ESL05627.1 - 3 7.6 12.1 3.2 7.5 0.4 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.10 ESL05627.1 - 5.2 6.6 28.9 1.4 8.4 2.3 5.4 2 2 5 7 7 7 0 Septum formation initiator Sin3_corepress PF08295.7 ESL05627.1 - 6.1 6.6 8.4 0.51 10.1 1.0 2.7 3 1 0 3 3 3 0 Sin3 family co-repressor FlaC_arch PF05377.6 ESL05627.1 - 7.4 6.5 15.5 4.9 7.1 0.0 4.6 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.4 ESL05627.1 - 8.4 6.0 16.6 1.6 8.3 0.6 3.7 3 1 1 4 4 4 0 Predicted coiled-coil protein (DUF2205) Phage_GP20 PF06810.6 ESL05627.1 - 9.6 5.6 21.8 3.8 6.9 1.7 4.0 1 1 4 5 5 5 0 Phage minor structural protein GP20 R3H PF01424.17 ESL05628.1 - 2.1e-11 43.3 0.0 4.2e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 ESL05628.1 - 1.1e-08 34.7 220.6 4e-05 23.4 8.1 15.4 15 2 0 15 15 15 9 NF-X1 type zinc finger Erythro-docking PF09277.6 ESL05629.1 - 0.031 13.9 1.2 0.53 10.0 0.1 2.6 2 0 0 2 2 2 0 Erythronolide synthase, docking Abhydrolase_6 PF12697.2 ESL05630.1 - 1.7e-26 93.4 2.1 2.5e-26 93.0 1.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL05630.1 - 1.2e-19 70.8 0.0 3.2e-18 66.1 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESL05630.1 - 7.6e-13 48.4 0.0 1.2e-05 25.1 0.0 2.3 2 1 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 ESL05630.1 - 5.7e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Ndr PF03096.9 ESL05630.1 - 0.00071 18.1 0.0 0.0063 15.0 0.0 2.1 2 1 0 2 2 2 1 Ndr family Esterase_phd PF10503.4 ESL05630.1 - 0.0025 17.1 0.2 0.4 9.9 0.1 2.3 2 0 0 2 2 2 2 Esterase PHB depolymerase Hydrolase_4 PF12146.3 ESL05630.1 - 0.0032 17.2 0.0 0.0082 15.9 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 ESL05630.1 - 0.004 16.4 0.0 0.089 12.0 0.0 2.3 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF2048 PF09752.4 ESL05630.1 - 0.017 13.9 0.3 0.057 12.2 0.2 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Esterase PF00756.15 ESL05630.1 - 0.018 14.5 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_2 PF02230.11 ESL05630.1 - 0.018 14.4 0.0 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Nodulin-like PF06813.8 ESL05631.1 - 1.9 7.6 15.4 0.93 8.7 6.1 2.8 2 2 0 2 2 2 0 Nodulin-like Ribosomal_L16 PF00252.13 ESL05632.1 - 2.4e-17 62.9 0.3 3.3e-17 62.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e TCTP PF00838.12 ESL05634.1 - 5.6e-38 130.5 2.9 6.3e-38 130.3 2.0 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF3384 PF11864.3 ESL05634.1 - 0.02 13.3 0.0 0.024 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) BOP1NT PF08145.7 ESL05634.1 - 0.032 13.9 0.1 0.038 13.7 0.1 1.1 1 0 0 1 1 1 0 BOP1NT (NUC169) domain Ribosomal_S20p PF01649.13 ESL05634.1 - 0.043 14.2 0.9 0.066 13.5 0.6 1.3 1 0 0 1 1 1 0 Ribosomal protein S20 Mus7 PF09462.5 ESL05634.1 - 0.052 12.3 0.1 0.06 12.1 0.1 1.0 1 0 0 1 1 1 0 Mus7/MMS22 family AlaDh_PNT_C PF01262.16 ESL05634.1 - 0.055 13.0 0.4 0.078 12.5 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF273 PF03314.9 ESL05634.1 - 0.072 12.3 0.4 0.16 11.2 0.2 1.5 1 1 1 2 2 2 0 Protein of unknown function, DUF273 IQ PF00612.22 ESL05636.1 - 1.7e-06 27.1 90.1 8.3e-05 21.8 0.9 11.4 12 0 0 12 12 12 7 IQ calmodulin-binding motif TRAP_alpha PF03896.11 ESL05636.1 - 5.9 5.7 19.4 16 4.3 13.5 1.7 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit EF-hand_1 PF00036.27 ESL05637.1 - 2.1e-14 51.6 14.7 4.8e-06 25.4 0.0 5.0 4 1 1 5 5 5 3 EF hand EF-hand_6 PF13405.1 ESL05637.1 - 1.6e-13 49.3 8.0 0.00024 20.7 0.2 4.3 4 1 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 ESL05637.1 - 1.8e-12 47.1 4.4 6.5e-07 29.3 0.3 3.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL05637.1 - 9.6e-09 34.7 11.0 0.00034 20.1 0.2 3.9 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 ESL05637.1 - 1e-08 34.0 0.3 0.00036 19.7 0.0 5.0 5 1 0 5 5 5 2 EF hand EF-hand_10 PF14788.1 ESL05637.1 - 0.0063 16.1 1.8 3.6 7.3 0.0 3.5 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.4 ESL05637.1 - 0.057 13.4 0.4 0.2 11.6 0.1 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Ribosomal_L30 PF00327.15 ESL05638.1 - 4.1e-18 64.7 1.0 1e-17 63.4 0.7 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 ESL05638.1 - 9.1e-17 60.8 12.4 1.7e-16 60.0 8.6 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L4 PF00573.17 ESL05639.1 - 9.1e-10 38.2 0.0 2.2e-09 36.9 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family Gp_dh_C PF02800.15 ESL05641.1 - 1.8e-63 212.6 0.1 2.8e-63 212.0 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL05641.1 - 1.6e-55 187.1 0.1 2.8e-55 186.4 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 ESL05641.1 - 0.0045 16.8 0.7 0.014 15.3 0.1 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 ESL05641.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Keratin_matx PF04579.7 ESL05642.1 - 0.085 13.1 0.2 0.15 12.3 0.2 1.4 1 0 0 1 1 1 0 Keratin, high-sulphur matrix protein WD40 PF00400.27 ESL05643.1 - 7.6e-37 123.8 20.7 1.7e-05 24.5 1.7 9.6 9 0 0 9 9 9 8 WD domain, G-beta repeat AAA_19 PF13245.1 ESL05643.1 - 0.012 15.3 0.0 0.046 13.4 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain DUF819 PF05684.7 ESL05644.1 - 0.0054 15.6 1.0 0.0069 15.2 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF819) Pterin_4a PF01329.14 ESL05644.1 - 0.087 12.5 1.2 0.26 11.0 0.0 2.2 3 0 0 3 3 3 0 Pterin 4 alpha carbinolamine dehydratase Ribosomal_L23 PF00276.15 ESL05645.1 - 1.5e-20 72.8 2.6 1.5e-20 72.8 1.8 2.5 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.8 ESL05645.1 - 9.8e-12 44.7 16.1 9.8e-12 44.7 11.2 2.3 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain P2 PF07194.6 ESL05645.1 - 0.051 13.4 0.4 0.096 12.5 0.3 1.4 1 0 0 1 1 1 0 P2 response regulator binding domain TusA PF01206.12 ESL05645.1 - 0.061 12.9 0.8 0.11 12.1 0.1 1.8 2 0 0 2 2 2 0 Sulfurtransferase TusA YmdB PF13277.1 ESL05645.1 - 0.12 11.3 0.1 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 YmdB-like protein DnaJ PF00226.26 ESL05645.1 - 0.15 11.7 1.6 10 5.9 0.0 2.9 3 0 0 3 3 3 0 DnaJ domain UFD1 PF03152.9 ESL05647.1 - 4.6e-48 162.6 0.0 5.5e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ZZ PF00569.12 ESL05648.1 - 7.6e-08 31.7 11.2 7.6e-08 31.7 7.7 2.6 2 0 0 2 2 2 1 Zinc finger, ZZ type TOM_sub5 PF15178.1 ESL05648.1 - 0.046 13.4 0.3 0.25 11.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial import receptor subunit TOM5 homolog GCC2_GCC3 PF07699.8 ESL05648.1 - 0.13 11.8 3.0 0.087 12.4 0.2 2.1 2 0 0 2 2 2 0 GCC2 and GCC3 Histone PF00125.19 ESL05649.1 - 9.5e-19 67.3 0.1 1.4e-18 66.7 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone PF00125.19 ESL05651.1 - 1.7e-23 82.5 1.5 1.9e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL05651.1 - 7.1e-06 25.9 0.7 9.9e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESL05651.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated CENP-S PF15630.1 ESL05651.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore component CENP-S YihI PF04220.7 ESL05651.1 - 0.52 9.6 2.3 0.69 9.2 1.6 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) DAGAT PF03982.8 ESL05652.1 - 1.3e-27 96.2 0.0 1.7e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase BNR_3 PF13859.1 ESL05654.1 - 6e-54 183.2 2.0 6.7e-54 183.0 1.4 1.0 1 0 0 1 1 1 1 BNR repeat-like domain Ribosomal_L15e PF00827.12 ESL05656.1 - 9.9e-88 292.6 10.8 1.1e-87 292.4 7.5 1.0 1 0 0 1 1 1 1 Ribosomal L15 Flagellar_rod PF05149.7 ESL05657.1 - 8.2e-109 363.2 33.1 8.2e-109 363.2 23.0 3.0 2 1 1 3 3 3 2 Paraflagellar rod protein Dynein_heavy PF03028.10 ESL05658.1 - 4.1e-191 636.6 0.0 1.1e-189 631.8 0.0 2.3 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESL05658.1 - 4.2e-117 391.1 11.5 4.2e-117 391.1 8.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESL05658.1 - 6.9e-95 316.9 0.0 1.7e-94 315.6 0.0 1.7 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESL05658.1 - 2.6e-69 233.1 0.1 1.2e-68 231.0 0.1 2.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESL05658.1 - 7.7e-56 188.4 0.8 1.9e-55 187.1 0.3 1.9 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 ESL05658.1 - 1e-50 172.4 5.3 2e-50 171.4 3.7 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESL05658.1 - 2.8e-31 108.6 0.0 7.4e-31 107.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESL05658.1 - 7e-22 77.6 0.0 2.9e-06 27.0 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL05658.1 - 2e-07 31.2 1.0 1.1 9.2 0.0 6.2 5 1 1 6 6 5 2 AAA ATPase domain AAA_22 PF13401.1 ESL05658.1 - 3.4e-06 27.2 0.3 1.9 8.6 0.0 5.3 4 0 0 4 4 4 2 AAA domain AAA PF00004.24 ESL05658.1 - 0.00035 20.7 0.0 1.4 9.1 0.0 4.5 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 ESL05658.1 - 0.00036 20.1 0.3 0.72 9.3 0.0 3.6 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.21 ESL05658.1 - 0.00055 19.4 3.1 0.19 11.2 0.1 3.8 5 0 0 5 5 5 1 Sigma-54 interaction domain AAA_19 PF13245.1 ESL05658.1 - 0.00073 19.2 0.4 2.9 7.6 0.0 3.8 3 0 0 3 3 3 2 Part of AAA domain FtsK_SpoIIIE PF01580.13 ESL05658.1 - 0.0011 18.4 0.2 1.2 8.6 0.0 3.2 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_17 PF13207.1 ESL05658.1 - 0.0024 18.6 0.0 16 6.2 0.0 4.8 4 0 0 4 4 3 0 AAA domain AAA_18 PF13238.1 ESL05658.1 - 0.011 16.0 0.1 27 5.0 0.0 4.8 5 0 0 5 5 3 0 AAA domain RNA_helicase PF00910.17 ESL05658.1 - 0.034 14.3 0.4 5.5 7.2 0.0 4.0 4 0 0 4 4 4 0 RNA helicase Mg_chelatase PF01078.16 ESL05658.1 - 0.057 12.5 0.1 20 4.2 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 ESL05658.1 - 0.16 11.4 1.0 5.7 6.5 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Aa_trans PF01490.13 ESL05659.1 - 6.8e-35 120.3 17.8 8.3e-35 120.0 12.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Dabb PF07876.7 ESL05660.1 - 3.7e-09 36.9 0.0 5.1e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF952 PF06108.7 ESL05660.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF952) Ribosomal_L6 PF00347.18 ESL05661.1 - 7.2e-24 84.0 1.7 3.4e-14 53.1 0.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF1551 PF07585.6 ESL05661.1 - 0.026 13.4 0.1 0.032 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1551) Hormone_2 PF00123.15 ESL05661.1 - 0.093 12.5 0.0 30 4.5 0.0 3.2 3 0 0 3 3 3 0 Peptide hormone HSP20 PF00011.16 ESL05661.1 - 0.094 12.5 0.4 0.3 10.9 0.0 2.0 2 1 0 2 2 2 0 Hsp20/alpha crystallin family Ribosom_S12_S23 PF00164.20 ESL05662.1 - 5.4e-30 103.3 0.1 7.8e-30 102.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 KMP11 PF03037.11 ESL05663.1 - 4.6e-56 187.3 17.3 5.1e-56 187.2 12.0 1.0 1 0 0 1 1 1 1 Kinetoplastid membrane protein 11 Apolipoprotein PF01442.13 ESL05663.1 - 0.0092 15.5 4.3 0.018 14.5 3.0 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain FCH PF00611.18 ESL05663.1 - 0.012 15.7 1.9 0.012 15.7 1.3 1.9 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Lyase_8_N PF08124.6 ESL05663.1 - 0.013 14.3 1.8 0.014 14.3 1.2 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain AAA_32 PF13654.1 ESL05663.1 - 0.018 13.7 3.9 0.02 13.5 2.7 1.0 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 ESL05663.1 - 0.048 11.0 4.5 0.058 10.7 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TroA PF01297.12 ESL05663.1 - 0.056 12.6 1.9 2.3 7.3 0.1 2.0 1 1 1 2 2 2 0 Periplasmic solute binding protein family THP2 PF09432.5 ESL05663.1 - 0.059 13.2 1.7 0.073 12.9 1.2 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 Metal_resist PF13801.1 ESL05663.1 - 0.072 13.0 1.1 0.24 11.3 0.1 1.8 1 1 1 2 2 2 0 Heavy-metal resistance Brr6_like_C_C PF10104.4 ESL05663.1 - 0.089 12.3 0.5 0.096 12.1 0.4 1.1 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain FliD_C PF07195.7 ESL05663.1 - 0.15 11.3 1.9 0.24 10.6 1.3 1.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus GrpE PF01025.14 ESL05663.1 - 0.2 11.1 5.8 0.22 11.0 4.1 1.1 1 0 0 1 1 1 0 GrpE T5orf172 PF10544.4 ESL05663.1 - 0.2 12.0 2.6 0.24 11.8 1.8 1.2 1 0 0 1 1 1 0 T5orf172 domain Herpes_BLRF2 PF05812.7 ESL05663.1 - 0.29 10.9 2.2 0.38 10.5 1.6 1.3 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein DUF4404 PF14357.1 ESL05663.1 - 0.32 11.4 3.7 1.1 9.7 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) NYD-SP28 PF14772.1 ESL05663.1 - 0.36 10.9 7.3 4.1 7.5 0.2 2.4 2 1 0 2 2 2 0 Sperm tail DIOX_N PF14226.1 ESL05663.1 - 0.58 10.7 4.8 0.71 10.4 3.4 1.1 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal ARL2_Bind_BART PF11527.3 ESL05663.1 - 0.69 9.7 9.5 1.1 9.0 6.5 1.3 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART YlqD PF11068.3 ESL05663.1 - 0.7 9.9 7.4 1.6 8.8 5.2 1.5 1 1 0 1 1 1 0 YlqD protein MRP-S27 PF10037.4 ESL05663.1 - 0.73 8.6 5.9 0.76 8.6 4.1 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF2884 PF11101.3 ESL05663.1 - 0.85 8.9 8.7 2.2 7.6 0.3 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2884) DUF922 PF06037.6 ESL05663.1 - 0.96 8.7 5.4 0.81 8.9 2.8 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF922) YtxH PF12732.2 ESL05663.1 - 1.4 9.3 3.4 3.9 7.9 2.3 1.8 1 1 0 1 1 1 0 YtxH-like protein DUF1140 PF06600.6 ESL05663.1 - 1.5 8.9 5.2 2.8 8.0 3.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1140) DUF3829 PF12889.2 ESL05663.1 - 2.1 7.4 9.6 3.1 6.9 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) TipAS PF07739.8 ESL05663.1 - 6.5 7.1 9.4 1.8 8.9 2.1 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain OMPdecase PF00215.19 ESL05664.1 - 2e-40 138.6 0.0 2.8e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.22 ESL05664.1 - 4.8e-16 58.6 2.5 1.4e-15 57.1 1.7 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.1 ESL05664.1 - 0.00082 18.7 0.0 0.0017 17.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.1 ESL05664.1 - 0.0017 17.5 0.0 0.0031 16.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase BRX PF08381.6 ESL05664.1 - 0.02 13.9 0.0 0.051 12.6 0.0 1.6 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 DXP_synthase_N PF13292.1 ESL05664.1 - 0.061 12.2 0.1 0.089 11.7 0.1 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Whirly PF08536.6 ESL05664.1 - 0.085 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Whirly transcription factor Phage_Coat_Gp8 PF05371.7 ESL05664.1 - 0.2 11.2 3.1 0.15 11.6 0.4 2.2 3 0 0 3 3 3 0 Phage major coat protein, Gp8 Diphthamide_syn PF01866.12 ESL05665.1 - 4.4e-31 108.2 0.9 7.4e-16 58.2 0.0 2.9 3 0 0 3 3 3 2 Putative diphthamide synthesis protein Peptidase_S80 PF07230.6 ESL05665.1 - 0.057 11.7 0.1 0.087 11.1 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage T4-like capsid assembly protein (Gp20) PI3_PI4_kinase PF00454.22 ESL05666.1 - 4.9e-48 163.6 0.1 1e-47 162.5 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESL05666.1 - 1.3e-41 142.8 3.0 9e-41 140.0 2.1 2.1 1 1 0 1 1 1 1 FAT domain Rapamycin_bind PF08771.6 ESL05666.1 - 8.1e-30 102.8 2.2 8.1e-30 102.8 1.5 2.4 2 0 0 2 2 2 1 Rapamycin binding domain DUF3385 PF11865.3 ESL05666.1 - 5.5e-23 81.6 1.2 3.3e-22 79.1 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) FATC PF02260.15 ESL05666.1 - 8e-11 41.1 0.8 9.3e-10 37.7 0.3 2.6 2 0 0 2 2 2 1 FATC domain HEAT PF02985.17 ESL05666.1 - 0.0034 17.3 5.9 2.9 8.1 0.1 6.4 7 0 0 7 7 7 1 HEAT repeat TPR_11 PF13414.1 ESL05666.1 - 0.69 9.5 8.0 0.25 11.0 1.2 3.0 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESL05666.1 - 1.9 8.6 4.7 11 6.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_C2 PF00648.16 ESL05667.1 - 5.4e-43 147.0 0.0 8e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESL05667.1 - 7.1e-24 83.7 0.0 1.6e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Dimerisation PF08100.6 ESL05667.1 - 0.17 11.7 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Dimerisation domain PPR_2 PF13041.1 ESL05669.1 - 0.0001 22.1 1.0 0.023 14.6 0.0 2.5 2 0 0 2 2 2 2 PPR repeat family DUF904 PF06005.7 ESL05670.1 - 0.015 15.6 6.3 0.015 15.6 4.4 5.5 2 2 3 5 5 5 0 Protein of unknown function (DUF904) TraH PF06122.6 ESL05670.1 - 0.95 8.1 6.1 5.1 5.8 0.1 2.4 2 0 0 2 2 2 0 Conjugative relaxosome accessory transposon protein MCPsignal PF00015.16 ESL05670.1 - 1.1 8.7 10.4 2.2 7.7 0.7 2.7 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.7 ESL05670.1 - 2.2 8.0 24.5 0.35 10.6 3.1 3.3 2 1 1 3 3 3 0 Laminin Domain II ATG16 PF08614.6 ESL05670.1 - 6.4 6.5 48.9 0.24 11.2 2.7 4.7 1 1 1 4 4 4 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.7 ESL05670.1 - 8.2 6.7 13.9 40 4.5 0.9 4.9 2 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein BNR_3 PF13859.1 ESL05671.1 - 6.2e-58 196.3 0.0 7.6e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05671.1 - 3e-07 30.0 0.0 5.6e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESL05671.1 - 2.1e-05 23.6 0.4 0.38 10.7 0.0 2.9 2 0 0 2 2 2 2 BNR/Asp-box repeat Vps4_C PF09336.5 ESL05672.1 - 3.9e-07 29.8 0.2 1.2e-06 28.3 0.1 1.9 2 1 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA PF00004.24 ESL05672.1 - 1.3e-05 25.3 0.0 6.9e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) tRNA_NucTransf2 PF09249.6 ESL05672.1 - 0.032 14.1 0.1 0.048 13.5 0.1 1.3 1 1 0 1 1 1 0 tRNA nucleotidyltransferase, second domain DUF3089 PF11288.3 ESL05672.1 - 0.09 11.9 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PUF PF00806.14 ESL05673.1 - 2.2e-09 36.2 0.1 0.0077 15.6 0.0 4.1 4 0 0 4 4 4 2 Pumilio-family RNA binding repeat RabGAP-TBC PF00566.13 ESL05675.1 - 1.5e-42 145.4 3.1 2e-42 145.0 2.2 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.3 ESL05675.1 - 0.0032 16.8 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3548) Aa_trans PF01490.13 ESL05676.1 - 1e-49 169.1 33.8 1.3e-49 168.7 23.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL05676.1 - 6.1e-10 38.4 18.6 1.3e-09 37.3 12.9 1.4 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESL05676.1 - 5.7e-08 31.7 22.0 5.7e-08 31.7 15.3 2.2 2 0 0 2 2 2 1 Amino acid permease Pyridoxal_deC PF00282.14 ESL05677.1 - 4.7e-27 94.4 0.0 9.4e-25 86.8 0.0 2.9 2 1 1 3 3 3 2 Pyridoxal-dependent decarboxylase conserved domain MORN PF02493.15 ESL05678.1 - 1.6e-57 187.8 140.6 0.0012 18.4 0.0 26.8 27 0 0 27 27 27 20 MORN repeat FYVE PF01363.16 ESL05678.1 - 9.5e-23 79.8 22.8 2e-18 66.0 7.3 2.5 2 0 0 2 2 2 2 FYVE zinc finger FYVE_2 PF02318.11 ESL05678.1 - 0.033 14.0 19.7 0.29 11.0 2.3 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger IBR PF01485.16 ESL05678.1 - 8.1 6.3 16.5 10 6.0 3.1 2.5 2 0 0 2 2 2 0 IBR domain LRR_4 PF12799.2 ESL05679.1 - 4.2e-57 188.9 61.2 1e-07 31.4 0.0 14.8 9 3 6 16 16 16 13 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL05679.1 - 7.1e-38 128.1 76.9 7e-06 25.7 0.7 12.2 9 3 5 15 15 15 12 Leucine rich repeat LRR_9 PF14580.1 ESL05679.1 - 1.1e-32 112.9 14.8 3.4e-06 26.7 0.0 8.8 3 3 5 8 8 8 7 Leucine-rich repeat LRR_1 PF00560.28 ESL05679.1 - 2.7e-07 29.6 64.8 7.7 6.9 0.1 19.4 19 2 0 19 19 19 5 Leucine Rich Repeat LRR_7 PF13504.1 ESL05679.1 - 1.1e-06 27.8 50.5 3.6 8.2 0.1 17.6 19 0 0 19 19 19 2 Leucine rich repeat LRR_6 PF13516.1 ESL05679.1 - 4.4e-06 26.2 56.4 2 8.7 0.7 17.7 16 3 4 20 20 20 2 Leucine Rich repeat DSBA PF01323.15 ESL05679.1 - 0.035 13.6 0.0 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 DSBA-like thioredoxin domain LRR_2 PF07723.8 ESL05679.1 - 0.8 10.3 10.5 19 5.9 0.4 5.4 5 1 0 5 5 5 0 Leucine Rich Repeat Kelch_4 PF13418.1 ESL05680.1 - 2.3e-34 116.9 7.2 1.5e-08 34.2 0.0 6.8 4 1 2 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL05680.1 - 1.9e-33 113.8 4.8 2.8e-07 30.4 0.1 7.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESL05680.1 - 6.9e-23 79.8 11.4 0.00068 19.7 0.0 6.4 4 2 2 6 6 6 6 Kelch motif Kelch_5 PF13854.1 ESL05680.1 - 2.8e-22 78.2 3.1 0.00018 21.3 0.0 6.5 6 0 0 6 6 6 5 Kelch motif DUF4110 PF13422.1 ESL05680.1 - 1.3e-18 66.5 8.6 1.3e-18 66.5 6.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4110) Kelch_1 PF01344.20 ESL05680.1 - 1.6e-18 65.9 10.8 0.0042 16.6 0.0 7.0 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESL05680.1 - 1.9e-14 52.7 7.3 0.017 14.8 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Plant_vir_prot PF01307.12 ESL05680.1 - 0.14 11.9 0.0 0.42 10.3 0.0 1.8 2 0 0 2 2 2 0 Plant viral movement protein Cyclin_N PF00134.18 ESL05681.1 - 3.8e-05 23.2 0.0 6.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain AAA PF00004.24 ESL05683.1 - 1.9e-39 134.8 0.0 3.9e-39 133.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL05683.1 - 1.4e-05 24.8 0.0 0.00017 21.3 0.0 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL05683.1 - 2.1e-05 24.5 0.1 0.015 15.3 0.0 2.4 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.9 ESL05683.1 - 0.00024 21.0 0.7 0.0012 18.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL05683.1 - 0.00047 20.2 0.4 0.028 14.5 0.2 2.6 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 ESL05683.1 - 0.00074 18.6 0.0 0.0015 17.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ESL05683.1 - 0.0012 17.8 0.0 0.0023 16.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 ESL05683.1 - 0.0023 17.3 0.7 0.016 14.5 0.2 2.2 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 ESL05683.1 - 0.0033 17.3 0.1 0.025 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 ESL05683.1 - 0.0049 16.0 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESL05683.1 - 0.0061 16.2 0.1 0.014 15.0 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 ESL05683.1 - 0.013 14.6 0.0 0.023 13.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin CPT PF07931.7 ESL05683.1 - 0.015 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein IstB_IS21 PF01695.12 ESL05683.1 - 0.018 14.4 0.1 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.11 ESL05683.1 - 0.023 13.9 0.0 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.7 ESL05683.1 - 0.024 14.2 0.1 0.54 9.9 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_3 PF07726.6 ESL05683.1 - 0.025 14.1 0.0 0.086 12.4 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 ESL05683.1 - 0.03 13.4 0.0 0.11 11.5 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_17 PF13207.1 ESL05683.1 - 0.037 14.8 2.5 0.047 14.5 0.2 2.4 2 2 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 ESL05683.1 - 0.051 13.0 0.0 0.33 10.4 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.1 ESL05683.1 - 0.064 12.8 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL05683.1 - 0.068 13.3 0.0 0.19 11.9 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_28 PF13521.1 ESL05683.1 - 0.069 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 ESL05683.1 - 0.18 10.6 0.0 0.4 9.5 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_18 PF13238.1 ESL05683.1 - 0.26 11.6 4.2 0.55 10.5 0.1 2.7 2 2 0 2 2 2 0 AAA domain Peptidase_M8 PF01457.11 ESL05684.1 - 1.8e-114 382.9 0.0 2.1e-114 382.7 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Ank_2 PF12796.2 ESL05685.1 - 4.9e-39 132.5 18.5 2.7e-08 34.0 0.0 10.4 8 2 2 10 10 10 6 Ankyrin repeats (3 copies) Ank PF00023.25 ESL05685.1 - 7.7e-23 79.1 41.9 0.02 14.7 0.1 13.6 14 0 0 14 14 14 9 Ankyrin repeat Ank_4 PF13637.1 ESL05685.1 - 3.7e-18 65.5 18.0 0.00046 20.6 0.3 9.7 8 3 2 10 10 10 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL05685.1 - 6e-18 64.4 21.4 0.00043 20.4 0.1 11.8 10 1 1 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL05685.1 - 1.1e-13 49.9 34.1 0.15 12.3 0.0 13.4 14 0 0 14 14 14 6 Ankyrin repeat SPRY PF00622.23 ESL05685.1 - 8.5e-08 32.3 0.3 6.1e-07 29.5 0.2 2.4 1 1 0 1 1 1 1 SPRY domain Bromo_TP PF07524.8 ESL05686.1 - 0.024 14.3 0.0 8.9 6.1 0.0 2.8 2 0 0 2 2 2 0 Bromodomain associated HECT PF00632.20 ESL05687.1 - 1.6e-38 132.6 0.0 3.1e-38 131.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESL05687.1 - 1.5e-25 89.7 0.9 2.7e-09 37.1 0.0 4.5 4 0 0 4 4 4 3 SPRY domain ZZ PF00569.12 ESL05687.1 - 0.003 17.0 11.7 0.012 15.1 8.1 2.0 1 0 0 1 1 1 1 Zinc finger, ZZ type B9-C2 PF07162.6 ESL05688.1 - 0.023 14.4 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein Ribosomal_L13 PF00572.13 ESL05690.1 - 1.3e-20 73.7 1.2 1.7e-20 73.3 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L13 TP53IP5 PF15331.1 ESL05690.1 - 0.11 12.4 3.3 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 RNB PF00773.14 ESL05691.1 - 2.7e-92 309.5 0.0 4.8e-92 308.7 0.0 1.4 2 0 0 2 2 2 1 RNB domain TCTP PF00838.12 ESL05691.1 - 0.018 15.0 0.3 0.035 14.0 0.2 1.4 1 0 0 1 1 1 0 Translationally controlled tumour protein Peptidase_S49_N PF08496.5 ESL05691.1 - 0.46 10.2 4.6 0.44 10.3 2.2 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TPR_7 PF13176.1 ESL05692.1 - 0.0024 17.5 9.7 0.29 11.0 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat DnaJ PF00226.26 ESL05693.1 - 6.1e-06 25.8 0.0 1.3e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain MutL_C PF08676.6 ESL05694.1 - 2.1e-28 98.7 0.0 4.2e-28 97.7 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 ESL05694.1 - 4.1e-13 48.8 0.0 7.9e-13 47.9 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 ESL05694.1 - 5.2e-08 32.6 0.0 9.9e-08 31.7 0.0 1.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESL05694.1 - 1.1e-07 31.5 0.0 2.2e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GvpH PF05455.6 ESL05694.1 - 0.029 14.0 0.1 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 GvpH Endonuclease_NS PF01223.18 ESL05695.1 - 3.7e-60 203.0 0.0 5e-60 202.6 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.1 ESL05695.1 - 0.014 15.3 0.4 0.036 14.1 0.3 1.6 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease TruD PF01142.13 ESL05696.1 - 1.5e-32 112.7 0.0 1.3e-31 109.5 0.0 2.1 2 1 0 2 2 2 1 tRNA pseudouridine synthase D (TruD) Cyt-b5 PF00173.23 ESL05697.1 - 3.3e-09 36.3 0.1 3.5e-07 29.9 0.0 2.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 ESL05697.1 - 0.00021 20.8 11.2 0.00029 20.3 7.7 1.2 1 0 0 1 1 1 1 Fatty acid desaturase PHB_acc_N PF07879.6 ESL05697.1 - 0.15 11.8 0.0 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain PI-PLC-X PF00388.14 ESL05699.1 - 2e-63 212.1 0.0 4.3e-63 211.0 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 ESL05699.1 - 2.6e-34 117.7 0.0 5.2e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 ESL05699.1 - 6.6e-12 45.1 0.0 1.2e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.1 ESL05699.1 - 1.4e-06 27.6 0.6 0.024 14.5 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain EF-hand_like PF09279.6 ESL05699.1 - 0.00012 22.0 0.1 0.00045 20.1 0.0 2.0 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.27 ESL05699.1 - 0.00015 20.7 0.5 0.03 13.6 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 ESL05699.1 - 0.00051 20.1 0.0 0.0023 18.0 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 ESL05699.1 - 0.017 14.4 0.5 1.9 7.9 0.0 2.6 2 0 0 2 2 2 0 EF hand IncA PF04156.9 ESL05700.1 - 5.4 6.5 85.8 0.29 10.6 15.8 4.4 3 1 1 4 4 4 0 IncA protein Peptidase_M22 PF00814.20 ESL05701.1 - 3.9e-85 285.5 0.0 5.1e-85 285.2 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family DUF2002 PF09400.5 ESL05701.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) CCDC84 PF14968.1 ESL05702.1 - 0.013 15.0 0.3 0.017 14.6 0.2 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 DUF3020 PF11223.3 ESL05702.1 - 1.8 8.9 9.3 0.8 10.1 3.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3020) Ribosomal_L14 PF00238.14 ESL05703.1 - 1.4e-36 124.8 0.0 1.6e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e tRNA_anti-codon PF01336.20 ESL05704.1 - 0.00054 19.7 0.1 0.00086 19.1 0.1 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SSB PF00436.20 ESL05704.1 - 0.0067 16.2 0.1 0.04 13.7 0.1 2.0 1 1 0 1 1 1 1 Single-strand binding protein family Ten1_2 PF15490.1 ESL05704.1 - 0.089 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit Cyclase PF04199.8 ESL05705.1 - 4.9e-09 36.1 0.0 6.9e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase DUF3429 PF11911.3 ESL05705.1 - 0.047 13.6 2.4 0.09 12.7 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) DUF2917 PF11142.3 ESL05705.1 - 0.17 11.1 1.9 0.16 11.1 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2917) Nucleoside_tran PF01733.13 ESL05707.1 - 1.1e-30 106.9 0.8 1.1e-30 106.9 0.6 2.0 2 1 0 2 2 2 1 Nucleoside transporter Vma12 PF11712.3 ESL05707.1 - 0.14 11.8 2.6 2.4 7.8 0.2 2.8 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase LRV PF01816.12 ESL05709.1 - 4.6 7.6 6.4 0.68 10.2 0.3 2.8 3 0 0 3 3 3 0 Leucine rich repeat variant Adap_comp_sub PF00928.16 ESL05711.1 - 3.2e-11 42.8 0.0 3.8e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Abhydrolase_5 PF12695.2 ESL05713.1 - 0.0022 17.7 0.0 0.01 15.5 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family DnaJ PF00226.26 ESL05714.1 - 0.011 15.3 0.2 0.062 13.0 0.0 2.2 2 0 0 2 2 2 0 DnaJ domain Ribosomal_L13 PF00572.13 ESL05718.1 - 0.052 13.6 0.6 0.19 11.7 0.0 2.0 1 1 1 2 2 2 0 Ribosomal protein L13 alpha-hel2 PF14456.1 ESL05718.1 - 0.12 11.1 0.8 0.14 10.9 0.6 1.1 1 0 0 1 1 1 0 Alpha-helical domain 2 DUF4455 PF14643.1 ESL05718.1 - 0.16 10.5 3.1 0.2 10.2 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) RRM_1 PF00076.17 ESL05719.1 - 0.00024 20.6 0.0 0.00052 19.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL05719.1 - 0.004 17.0 0.0 0.0099 15.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL05719.1 - 0.078 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aa_trans PF01490.13 ESL05720.1 - 4.9e-42 143.8 15.1 6.2e-41 140.2 10.5 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2583 PF10762.4 ESL05720.1 - 2 8.5 5.3 1 9.5 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) Ribonuc_red_sm PF00268.16 ESL05721.1 - 1e-113 379.0 0.2 1.2e-113 378.8 0.1 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain HECT PF00632.20 ESL05722.1 - 6.2e-37 127.4 0.0 1.2e-36 126.5 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESL05722.1 - 7.4e-14 51.9 0.1 1.3e-10 41.3 0.0 2.6 2 0 0 2 2 2 2 SPRY domain zf-RanBP PF00641.13 ESL05722.1 - 0.00067 18.7 1.9 0.00067 18.7 1.3 3.2 2 1 1 3 3 3 1 Zn-finger in Ran binding protein and others GCR PF02155.10 ESL05723.1 - 0.0037 16.0 4.2 0.85 8.2 2.2 2.6 2 1 1 3 3 3 3 Glucocorticoid receptor BAR_3_WASP_bdg PF10456.4 ESL05723.1 - 0.041 13.1 3.0 0.6 9.3 0.7 2.9 3 0 0 3 3 3 0 WASP-binding domain of Sorting nexin protein Pup PF05639.6 ESL05723.1 - 0.12 12.8 0.6 0.35 11.4 0.4 1.8 1 0 0 1 1 1 0 Pup-like protein PSK_trans_fac PF07704.6 ESL05723.1 - 0.15 12.7 2.2 0.25 12.0 0.4 2.3 1 1 0 1 1 1 0 Rv0623-like transcription factor Med11 PF10280.4 ESL05723.1 - 0.69 9.9 9.0 3.3 7.7 5.6 2.5 1 1 0 1 1 1 0 Mediator complex protein zf-C2HC_2 PF13913.1 ESL05724.1 - 3.8e-21 74.2 14.1 1.5e-09 37.2 0.3 3.6 3 0 0 3 3 3 3 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.1 ESL05724.1 - 8.5e-05 21.6 1.1 8.5e-05 21.6 0.8 3.7 4 0 0 4 4 4 1 zinc-ribbon domain DZR PF12773.2 ESL05724.1 - 0.0001 22.0 0.6 0.0001 22.0 0.4 4.1 3 1 0 3 3 3 1 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESL05724.1 - 0.00026 20.3 2.6 0.00026 20.3 1.8 3.1 3 0 0 3 3 3 1 zinc-ribbon domain DUF164 PF02591.10 ESL05724.1 - 0.036 13.9 4.8 1.6 8.5 0.1 3.5 4 0 0 4 4 4 0 Putative zinc ribbon domain zf-NADH-PPase PF09297.6 ESL05724.1 - 0.071 12.6 6.1 0.081 12.4 0.1 3.6 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain Sgf11 PF08209.6 ESL05724.1 - 0.17 11.2 8.0 1.8 7.9 0.1 3.1 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) NinF PF05810.7 ESL05724.1 - 0.28 10.9 2.6 2.3 8.0 0.2 2.9 2 0 0 2 2 2 0 NinF protein HypA PF01155.14 ESL05724.1 - 2 8.1 10.0 2.1 8.0 0.0 3.4 4 0 0 4 4 4 0 Hydrogenase expression/synthesis hypA family zf-C2H2 PF00096.21 ESL05724.1 - 7.2 7.1 18.8 0.085 13.2 0.6 3.8 4 0 0 4 4 3 0 Zinc finger, C2H2 type DUF35_N PF12172.3 ESL05724.1 - 8.6 6.4 12.6 0.1 12.5 0.3 3.2 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) WD40 PF00400.27 ESL05726.1 - 1.5e-17 62.7 21.1 2.8e-05 23.8 0.1 8.9 10 0 0 10 10 10 5 WD domain, G-beta repeat PQQ_3 PF13570.1 ESL05726.1 - 0.069 13.4 5.2 4.4 7.7 0.0 5.0 5 0 0 5 5 5 0 PQQ-like domain Ras PF00071.17 ESL05727.1 - 2.7e-59 199.2 0.2 3.2e-59 198.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL05727.1 - 1.8e-22 80.0 0.0 2.7e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL05727.1 - 1.3e-13 50.6 0.0 1.6e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL05727.1 - 4.3e-05 23.0 0.0 0.00024 20.5 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL05727.1 - 0.00026 20.1 0.0 0.00032 19.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESL05727.1 - 0.00032 19.9 0.0 0.00054 19.2 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL05727.1 - 0.0022 17.9 0.0 0.0037 17.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESL05727.1 - 0.026 14.6 0.0 2.8 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESL05727.1 - 0.026 13.9 0.1 0.28 10.6 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NRDE PF05742.7 ESL05727.1 - 0.053 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 NRDE protein CPT PF07931.7 ESL05727.1 - 0.17 11.5 1.0 0.37 10.3 0.0 2.1 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Vps23_core PF09454.5 ESL05731.1 - 1.7e-21 75.5 0.1 2.9e-21 74.8 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain UEV PF05743.8 ESL05731.1 - 0.021 14.5 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 UEV domain Ribosomal_S5_C PF03719.10 ESL05732.1 - 8e-25 85.9 0.0 1.3e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 ESL05732.1 - 3.5e-19 68.3 2.0 4.9e-19 67.8 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Peptidase_M32 PF02074.10 ESL05733.1 - 1.4e-83 281.2 0.0 1.6e-83 281.0 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase DUF1767 PF08585.7 ESL05734.1 - 0.00057 20.0 0.6 0.0012 19.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1767) FAM178 PF14816.1 ESL05735.1 - 0.2 10.3 4.1 0.23 10.1 2.9 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 DUF4610 PF15384.1 ESL05735.1 - 0.36 10.3 4.5 0.4 10.1 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4610) DUF3619 PF12279.3 ESL05735.1 - 1.1 9.3 3.5 1 9.4 2.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3619) DUF501 PF04417.7 ESL05735.1 - 3.2 7.5 5.6 3.8 7.3 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Cyclin PF08613.6 ESL05736.1 - 1.6e-22 80.5 0.2 2e-22 80.2 0.1 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESL05736.1 - 9.9e-08 31.6 0.3 1.3e-07 31.2 0.2 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain NUDIX PF00293.23 ESL05737.1 - 9.8e-14 51.1 0.0 1.6e-13 50.4 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain Borrelia_REV PF03978.8 ESL05737.1 - 0.13 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Enolase_C PF00113.17 ESL05740.1 - 1e-82 277.4 0.0 1.4e-82 277.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 ESL05740.1 - 8.1e-58 194.0 0.0 1.3e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE PF01188.16 ESL05740.1 - 0.017 15.6 0.0 0.045 14.2 0.0 1.8 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Ribosomal_S15 PF00312.17 ESL05742.1 - 8.6e-24 83.1 0.3 9.7e-24 82.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S15 DSPc PF00782.15 ESL05743.1 - 1.5e-25 89.2 0.1 2.7e-09 36.7 0.1 3.2 3 0 0 3 3 3 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL05743.1 - 0.056 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase UCR_hinge PF02320.11 ESL05744.1 - 4.8e-21 74.4 3.7 5.4e-21 74.2 2.6 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Tr-sialidase_C PF11052.3 ESL05745.1 - 1.4e-06 28.0 1.8 2.5e-06 27.2 1.3 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESL05745.1 - 0.038 14.2 0.5 0.062 13.5 0.0 1.5 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily Peptidase_M8 PF01457.11 ESL05746.1 - 6.5e-41 140.2 0.5 6.9e-41 140.1 0.3 1.0 1 0 0 1 1 1 1 Leishmanolysin Chorein_N PF12624.2 ESL05747.1 - 3.6e-31 107.1 0.0 8.3e-31 105.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter 2-Hacid_dh_C PF02826.14 ESL05748.1 - 2.1e-45 154.0 0.0 2.8e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESL05748.1 - 1.5e-05 24.4 0.0 2.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_10 PF13460.1 ESL05748.1 - 2.3e-05 24.4 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding F420_oxidored PF03807.12 ESL05748.1 - 8.6e-05 22.9 0.0 0.00088 19.6 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 ESL05748.1 - 0.00026 20.9 0.1 0.00054 19.9 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESL05748.1 - 0.00069 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.1 ESL05748.1 - 0.0091 16.2 0.0 0.059 13.6 0.0 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding AdoHcyase_NAD PF00670.16 ESL05748.1 - 0.013 15.3 0.1 0.043 13.6 0.0 1.7 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.14 ESL05748.1 - 0.023 13.3 0.0 0.034 12.8 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.16 ESL05748.1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Gp_dh_N PF00044.19 ESL05748.1 - 0.057 13.3 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESL05748.1 - 0.058 13.0 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 ESL05748.1 - 0.079 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase XdhC_C PF13478.1 ESL05748.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain Ribosomal_L40e PF01020.12 ESL05749.1 - 2.7e-34 116.5 13.0 2.9e-34 116.4 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L40e family zf-CHY PF05495.7 ESL05749.1 - 0.014 15.4 3.3 0.017 15.2 2.3 1.1 1 0 0 1 1 1 0 CHY zinc finger VWC PF00093.13 ESL05749.1 - 0.017 15.2 2.8 0.02 14.9 2.0 1.1 1 0 0 1 1 1 0 von Willebrand factor type C domain SBP PF03110.9 ESL05749.1 - 0.023 14.9 2.7 0.025 14.7 1.9 1.1 1 0 0 1 1 1 0 SBP domain DZR PF12773.2 ESL05749.1 - 0.034 13.9 2.9 0.047 13.5 2.0 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS91 PF14319.1 ESL05749.1 - 0.037 13.5 4.1 0.04 13.4 2.9 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-DHHC PF01529.15 ESL05749.1 - 0.58 9.5 3.5 0.65 9.3 2.5 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF4428 PF14471.1 ESL05749.1 - 0.69 9.7 3.3 18 5.1 2.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) FYVE PF01363.16 ESL05749.1 - 2.4 8.1 8.5 5.4 6.9 0.4 2.0 1 1 1 2 2 2 0 FYVE zinc finger KOW PF00467.24 ESL05750.1 - 2.1e-06 27.1 1.4 4e-06 26.3 0.3 2.2 2 1 0 2 2 2 1 KOW motif RNA_ligase PF09414.5 ESL05751.1 - 1.8e-51 174.5 0.0 2.9e-51 173.9 0.0 1.3 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_M PF01068.16 ESL05751.1 - 0.002 17.5 0.0 0.0042 16.4 0.0 1.6 2 0 0 2 2 2 1 ATP dependent DNA ligase domain FLILHELTA PF10306.4 ESL05751.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA Nup96 PF12110.3 ESL05752.1 - 6.9e-31 107.4 0.0 1e-30 106.8 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 ESL05752.1 - 1.3e-21 76.8 0.0 3.2e-21 75.6 0.0 1.7 1 1 0 1 1 1 1 Nucleoporin autopeptidase Dynein_heavy PF03028.10 ESL05753.1 - 7.3e-226 751.5 5.3 8.5e-225 748.0 0.0 3.7 4 0 0 4 4 3 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESL05753.1 - 6.7e-127 423.3 13.0 6.7e-127 423.3 9.0 3.7 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESL05753.1 - 2.1e-91 305.5 0.0 7.5e-91 303.7 0.0 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESL05753.1 - 1.2e-64 217.9 0.7 2.3e-64 216.9 0.5 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESL05753.1 - 3.8e-57 192.7 0.2 8.9e-57 191.5 0.1 1.7 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESL05753.1 - 9.1e-45 152.8 9.9 1.4e-44 152.2 6.9 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESL05753.1 - 9.5e-41 139.6 0.0 1.7e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESL05753.1 - 9.5e-15 54.5 0.1 0.00066 19.4 0.0 6.5 5 2 1 6 6 6 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESL05753.1 - 1.6e-09 38.0 0.0 0.0011 19.0 0.0 5.8 5 0 0 5 5 5 1 AAA domain AAA PF00004.24 ESL05753.1 - 6.2e-07 29.6 0.0 0.26 11.4 0.0 4.7 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ESL05753.1 - 2.9e-06 27.3 0.0 0.05 13.7 0.0 4.4 4 0 0 4 4 4 2 RNA helicase AAA_16 PF13191.1 ESL05753.1 - 2.8e-05 24.1 4.7 0.72 9.8 0.0 5.4 4 1 1 5 5 5 2 AAA ATPase domain NACHT PF05729.7 ESL05753.1 - 4.7e-05 23.1 0.3 0.0098 15.5 0.0 3.5 3 0 0 3 3 2 1 NACHT domain AAA_17 PF13207.1 ESL05753.1 - 0.00011 23.0 0.0 1.8 9.3 0.0 5.3 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.1 ESL05753.1 - 0.0021 17.4 0.5 1.4 8.2 0.0 3.6 3 0 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.20 ESL05753.1 - 0.011 15.2 0.0 0.37 10.2 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.1 ESL05753.1 - 0.011 16.0 0.0 12 6.2 0.0 4.4 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 ESL05753.1 - 0.015 15.0 1.7 0.67 9.7 0.1 3.4 4 0 0 4 4 3 0 Part of AAA domain AAA_33 PF13671.1 ESL05753.1 - 0.035 13.9 0.2 2.4 8.0 0.0 3.5 3 0 0 3 3 2 0 AAA domain Miro PF08477.8 ESL05753.1 - 0.057 13.9 0.1 2 8.9 0.0 3.4 3 0 0 3 3 2 0 Miro-like protein Mg_chelatase PF01078.16 ESL05753.1 - 0.2 10.7 1.6 32 3.6 0.0 4.3 5 0 0 5 5 5 0 Magnesium chelatase, subunit ChlI DUF853 PF05872.7 ESL05753.1 - 9.4 4.4 10.6 1.7 6.9 0.0 3.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF853) Metallophos PF00149.23 ESL05754.1 - 0.0022 17.4 0.1 0.0099 15.2 0.0 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase SKG6 PF08693.5 ESL05754.1 - 0.048 12.9 3.6 0.12 11.6 2.5 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF3926 PF13080.1 ESL05754.1 - 0.052 13.0 0.6 7.1 6.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) TMEM154 PF15102.1 ESL05754.1 - 0.094 12.4 0.0 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family SIT PF15330.1 ESL05754.1 - 0.46 10.6 0.0 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT zf-rbx1 PF12678.2 ESL05755.1 - 5e-11 42.5 4.6 9.6e-11 41.6 3.2 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESL05755.1 - 9e-11 41.4 10.0 1.9e-10 40.4 6.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL05755.1 - 3.9e-07 29.9 11.1 7.9e-07 28.9 7.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL05755.1 - 2.5e-06 27.0 6.9 5e-06 26.0 4.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL05755.1 - 4.4e-06 26.3 8.6 9.8e-06 25.2 6.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL05755.1 - 1.1e-05 24.9 11.2 2.1e-05 24.0 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL05755.1 - 0.00065 19.4 6.8 0.0022 17.8 4.7 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ESL05755.1 - 0.0018 17.9 2.6 0.0018 17.9 1.8 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.3 ESL05755.1 - 0.15 11.5 3.4 0.27 10.7 2.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 ESL05755.1 - 0.31 10.9 8.1 1 9.2 5.6 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.24 ESL05755.1 - 0.63 9.7 8.5 1.5 8.6 5.9 1.7 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.2 ESL05755.1 - 1.7 8.7 9.8 3.4 7.7 6.8 1.5 1 0 0 1 1 1 0 RING-variant domain Nodulin-like PF06813.8 ESL05756.1 - 2.4e-11 43.3 7.4 2.4e-11 43.3 5.1 2.4 2 0 0 2 2 2 1 Nodulin-like SpoU_methylase PF00588.14 ESL05757.1 - 2e-05 24.4 0.0 5.5e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 SpoU rRNA Methylase family Beach PF02138.13 ESL05758.1 - 6.7e-100 333.9 0.0 1.3e-99 333.0 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 ESL05758.1 - 6.7e-13 48.4 0.0 1.6e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 ESL05758.1 - 3.7e-11 43.4 0.0 1.2e-10 41.8 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.27 ESL05758.1 - 5.4e-10 38.7 1.6 0.004 16.9 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESL05758.1 - 0.081 12.4 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Myc_N PF01056.13 ESL05758.1 - 5.1 6.1 6.1 0.47 9.5 0.3 1.9 2 0 0 2 2 2 0 Myc amino-terminal region Tex_N PF09371.5 ESL05759.1 - 2.3e-43 147.7 0.5 4.3e-43 146.8 0.3 1.4 1 0 0 1 1 1 1 Tex-like protein N-terminal domain HHH_3 PF12836.2 ESL05759.1 - 1.5e-08 34.4 0.3 5.6e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif YqgF PF14639.1 ESL05759.1 - 9.5e-06 25.2 0.0 2.3e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 S1 PF00575.18 ESL05759.1 - 0.0013 18.7 0.3 0.0032 17.5 0.2 1.7 1 0 0 1 1 1 1 S1 RNA binding domain HHH_7 PF14635.1 ESL05759.1 - 0.0046 17.0 0.0 0.0096 16.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif Latarcin PF10279.4 ESL05759.1 - 0.3 11.2 1.2 1.1 9.5 0.8 1.9 1 0 0 1 1 1 0 Latarcin precursor LSM PF01423.17 ESL05760.1 - 9.1e-10 37.9 0.0 1.2e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain Ribos_L4_asso_C PF14374.1 ESL05761.1 - 7.9e-15 54.5 4.0 7.9e-15 54.5 2.7 2.1 2 1 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ribosomal_L4 PF00573.17 ESL05761.1 - 1.1e-13 51.0 0.0 2e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family MBOAT PF03062.14 ESL05762.1 - 2.7e-36 125.3 25.5 2.7e-36 125.3 17.7 2.0 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family PapD_N PF00345.15 ESL05764.1 - 7e-09 35.5 0.7 0.041 13.6 0.0 6.8 9 0 0 9 9 9 2 Pili and flagellar-assembly chaperone, PapD N-terminal domain Motile_Sperm PF00635.21 ESL05764.1 - 2.1e-07 30.5 2.1 3 7.5 0.0 7.7 8 0 0 8 8 8 2 MSP (Major sperm protein) domain MYCBPAP PF14646.1 ESL05764.1 - 5e-07 28.7 0.0 0.43 9.2 0.0 3.7 3 0 0 3 3 3 3 MYCBP-associated protein family FixG_C PF11614.3 ESL05764.1 - 7.6e-05 22.7 0.1 1.2 9.2 0.0 5.8 7 0 0 7 7 7 1 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF3651 PF12371.3 ESL05764.1 - 0.0012 18.8 0.1 6.1 6.9 0.0 5.7 5 0 0 5 5 5 1 Protein of unknown function (DUF3651) GreA_GreB PF01272.14 ESL05764.1 - 0.1 12.3 0.0 7.5 6.3 0.0 3.4 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term DUF1735 PF08522.5 ESL05764.1 - 0.34 11.3 0.0 28 5.1 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1735) Pox_I5 PF04713.7 ESL05765.1 - 0.035 13.8 0.3 0.074 12.7 0.2 1.5 1 0 0 1 1 1 0 Poxvirus protein I5 Pkinase PF00069.20 ESL05766.1 - 6.5e-70 235.2 0.0 9.6e-70 234.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05766.1 - 1.2e-36 126.0 0.0 1.8e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05766.1 - 8.7e-10 38.0 0.0 1.6e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 ESL05766.1 - 0.023 13.5 0.1 0.083 11.7 0.1 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 APH PF01636.18 ESL05766.1 - 0.061 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESL05766.1 - 0.13 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinesin PF00225.18 ESL05768.1 - 8.2e-91 304.1 0.0 1.1e-90 303.7 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain RecO_C PF02565.10 ESL05768.1 - 0.055 13.3 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Recombination protein O C terminal Acyl-ACP_TE PF01643.12 ESL05769.1 - 6.1e-05 22.0 0.0 0.00038 19.4 0.0 1.9 1 1 1 2 2 2 1 Acyl-ACP thioesterase 4HBT_2 PF13279.1 ESL05769.1 - 0.015 15.7 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 Thioesterase-like superfamily Aa_trans PF01490.13 ESL05770.1 - 1.8e-29 102.4 14.9 2.1e-29 102.2 10.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ribosomal_S19 PF00203.16 ESL05771.1 - 5.3e-28 96.4 0.3 9.4e-28 95.6 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S19 PmbA_TldD PF01523.11 ESL05771.1 - 0.023 13.9 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Ribosomal_S21e PF01249.13 ESL05772.1 - 1e-29 102.2 0.2 1.4e-29 101.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S21e U79_P34 PF03064.11 ESL05772.1 - 8.3 5.8 12.4 11 5.4 8.6 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DSPc PF00782.15 ESL05774.1 - 0.00018 21.1 0.1 0.0019 17.7 0.0 2.8 5 0 0 5 5 5 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL05774.1 - 0.0009 18.6 0.2 1.7 7.9 0.0 2.9 3 0 0 3 3 3 2 Protein-tyrosine phosphatase Rotamase_3 PF13616.1 ESL05775.1 - 1.8e-22 79.7 0.0 2.2e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.16 ESL05775.1 - 3.9e-22 78.7 0.0 6e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 ESL05775.1 - 2.2e-09 37.9 0.0 3.3e-09 37.4 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain UCH PF00443.24 ESL05776.1 - 2.1e-27 95.9 0.0 3.1e-27 95.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL05776.1 - 3e-16 59.7 0.0 4e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FAT PF02259.18 ESL05777.1 - 7.1e-58 196.2 5.4 1.5e-57 195.2 3.8 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 ESL05777.1 - 7.5e-58 195.7 0.1 1.5e-57 194.8 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.3 ESL05777.1 - 3.4e-30 105.0 0.4 3.4e-30 105.0 0.3 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) Rapamycin_bind PF08771.6 ESL05777.1 - 9.5e-25 86.5 0.6 9.5e-25 86.5 0.4 3.0 3 1 0 3 3 3 1 Rapamycin binding domain FATC PF02260.15 ESL05777.1 - 5.5e-16 57.6 0.1 1.5e-15 56.2 0.0 1.8 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.1 ESL05777.1 - 3.4e-05 24.1 14.6 1.3 9.5 0.3 8.9 8 1 1 9 9 9 2 HEAT-like repeat UME PF08064.8 ESL05777.1 - 4.5e-05 23.3 2.9 0.088 12.7 0.0 4.8 4 1 0 4 4 4 2 UME (NUC010) domain DUF3856 PF12968.2 ESL05777.1 - 0.098 12.4 0.7 0.98 9.2 0.1 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_19 PF14559.1 ESL05777.1 - 0.13 12.6 4.1 11 6.4 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat AKAP7_NLS PF10469.4 ESL05778.1 - 5.1e-40 137.4 0.0 6e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 ESL05778.1 - 8.1e-09 35.3 0.0 1.1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.11 ESL05778.1 - 0.00047 20.0 0.0 0.1 12.6 0.0 2.4 2 0 0 2 2 2 2 LigT like Phosphoesterase DUF1275 PF06912.6 ESL05779.1 - 0.61 9.2 9.7 0.92 8.6 6.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1275) Galactosyl_T PF01762.16 ESL05780.1 - 2e-09 37.3 0.0 0.0015 18.1 0.0 3.7 4 0 0 4 4 4 2 Galactosyltransferase Filament PF00038.16 ESL05781.1 - 0.018 14.5 38.7 0.046 13.2 3.7 4.2 3 1 0 3 3 3 0 Intermediate filament protein DUF3658 PF12395.3 ESL05781.1 - 3.7 7.1 10.0 0.96 9.0 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function Galactosyl_T PF01762.16 ESL05783.1 - 0.00073 19.1 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 2 2 Galactosyltransferase Gp_dh_C PF02800.15 ESL05784.1 - 5.3e-64 214.4 0.1 6.4e-64 214.1 0.1 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL05784.1 - 0.0017 18.3 0.1 0.004 17.1 0.1 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain MFS_1 PF07690.11 ESL05785.1 - 1.1e-19 70.4 33.4 8.1e-16 57.6 23.2 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05785.1 - 2.5e-11 43.3 20.1 2.5e-11 43.3 13.9 2.6 2 2 0 2 2 2 1 Nodulin-like zf-B_box PF00643.19 ESL05786.1 - 4.9e-06 26.3 2.0 1.1e-05 25.1 1.4 1.6 1 0 0 1 1 1 1 B-box zinc finger Exonuc_VII_L PF02601.10 ESL05786.1 - 0.006 15.8 0.5 0.0093 15.1 0.3 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit AAA_13 PF13166.1 ESL05786.1 - 0.056 11.9 0.7 0.076 11.4 0.5 1.1 1 0 0 1 1 1 0 AAA domain DUF2317 PF10079.4 ESL05786.1 - 0.095 11.2 2.5 0.13 10.8 1.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) PilJ PF13675.1 ESL05786.1 - 0.096 13.0 0.7 0.22 11.8 0.2 1.9 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Lectin_N PF03954.9 ESL05786.1 - 0.14 11.5 0.5 0.68 9.3 0.2 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain GST_C_2 PF13410.1 ESL05786.1 - 0.27 11.1 2.7 6.6 6.6 0.4 3.3 2 2 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF2205 PF10224.4 ESL05786.1 - 0.47 10.0 3.4 0.82 9.2 1.2 2.0 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Sugar_tr PF00083.19 ESL05788.1 - 4.7e-95 318.8 42.6 6.3e-94 315.0 29.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL05788.1 - 3.6e-17 62.1 29.5 1.2e-13 50.4 20.2 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Syndecan PF01034.15 ESL05788.1 - 0.33 10.6 0.0 0.33 10.6 0.0 3.3 5 0 0 5 5 5 0 Syndecan domain Peptidase_C1 PF00112.18 ESL05789.1 - 4.7e-67 226.0 4.2 6.9e-67 225.5 2.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.3 ESL05789.1 - 2.4e-23 81.9 8.4 2.4e-23 81.9 5.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.7 ESL05789.1 - 2.3e-10 40.6 0.0 3.4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 ESL05789.1 - 0.0001 20.9 0.4 0.0023 16.5 0.0 2.0 2 0 0 2 2 2 1 Peptidase C1-like family Kinesin PF00225.18 ESL05790.1 - 1.8e-103 345.8 0.0 4.5e-103 344.4 0.0 1.7 1 0 0 1 1 1 1 Kinesin motor domain TMF_DNA_bd PF12329.3 ESL05790.1 - 0.0065 16.2 2.8 0.0065 16.2 1.9 6.5 6 2 0 6 6 6 2 TATA element modulatory factor 1 DNA binding DUF1846 PF08903.6 ESL05790.1 - 0.033 12.6 3.2 0.062 11.7 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) Rox3 PF08633.5 ESL05790.1 - 0.11 12.8 7.0 0.047 13.9 0.4 2.9 2 2 1 3 3 3 0 Rox3 mediator complex subunit AAA_22 PF13401.1 ESL05790.1 - 0.27 11.3 0.0 0.27 11.3 0.0 3.7 4 1 0 4 4 4 0 AAA domain DUF3802 PF12290.3 ESL05790.1 - 2.1 8.6 15.7 7.4 6.9 0.3 4.9 3 2 1 4 4 4 0 Protein of unknown function (DUF3802) tRNA-synt_1c PF00749.16 ESL05790.1 - 2.8 6.5 14.2 0.067 11.8 2.6 2.7 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF641 PF04859.7 ESL05790.1 - 3.5 7.4 42.2 2.5 7.8 4.5 6.1 5 1 1 6 6 6 0 Plant protein of unknown function (DUF641) AAA PF00004.24 ESL05790.1 - 4.2 7.5 8.1 3.7 7.7 0.0 3.8 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) Ribosomal_L10 PF00466.15 ESL05794.1 - 3.8e-25 87.7 0.2 7.3e-25 86.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 ESL05794.1 - 1.3e-05 25.5 0.7 1.3e-05 25.5 0.5 2.2 2 1 0 2 2 2 1 60s Acidic ribosomal protein zf-C2H2 PF00096.21 ESL05796.1 - 0.0049 17.1 2.5 0.018 15.3 1.2 2.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESL05796.1 - 0.026 14.8 0.7 0.11 12.8 0.5 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger DivIC PF04977.10 ESL05796.1 - 0.026 14.0 0.4 0.026 14.0 0.3 2.4 3 0 0 3 3 3 0 Septum formation initiator Dzip-like_N PF13815.1 ESL05796.1 - 0.041 13.6 2.1 0.13 12.0 1.4 1.8 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Kinesin-relat_1 PF12711.2 ESL05796.1 - 0.22 11.9 4.7 6.3 7.2 0.6 3.3 3 0 0 3 3 3 0 Kinesin motor Mnd1 PF03962.10 ESL05796.1 - 1.1 8.8 4.1 1.1 8.9 0.9 2.3 2 0 0 2 2 2 0 Mnd1 family HALZ PF02183.13 ESL05796.1 - 4.5 7.0 5.3 7.2 6.4 0.0 2.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper TMF_TATA_bd PF12325.3 ESL05796.1 - 4.8 6.9 11.0 0.089 12.5 1.8 2.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding ORC6 PF05460.8 ESL05798.1 - 0.056 12.5 1.1 0.26 10.3 0.6 1.8 1 1 1 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Dynamin_N PF00350.18 ESL05798.1 - 0.16 11.8 0.0 0.3 10.8 0.0 1.5 1 1 0 1 1 1 0 Dynamin family Lactamase_B PF00753.22 ESL05799.1 - 2.3e-14 53.4 1.9 2.3e-08 33.9 0.1 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESL05799.1 - 0.0024 17.4 0.5 0.01 15.3 0.3 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Phage_XkdX PF09693.5 ESL05799.1 - 0.19 11.3 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Phage uncharacterised protein (Phage_XkdX) Aminotran_1_2 PF00155.16 ESL05800.1 - 1.7e-78 264.1 0.0 1.9e-78 263.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 ESL05800.1 - 0.00022 20.4 0.0 0.076 12.0 0.0 2.1 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 ESL05800.1 - 0.00039 19.2 0.0 0.00088 18.1 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESL05800.1 - 0.00084 18.5 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.2 ESL05800.1 - 0.0047 15.5 0.0 0.007 14.9 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Cys_Met_Meta_PP PF01053.15 ESL05800.1 - 0.0072 14.6 0.0 0.011 14.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PSP1 PF04468.7 ESL05801.1 - 6.3e-28 96.6 0.4 1.5e-27 95.4 0.2 1.7 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Pox_I5 PF04713.7 ESL05802.1 - 0.039 13.6 0.3 0.073 12.7 0.2 1.4 1 0 0 1 1 1 0 Poxvirus protein I5 Peptidase_C1 PF00112.18 ESL05803.1 - 4.5e-67 226.1 4.2 6.7e-67 225.5 2.9 1.3 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.3 ESL05803.1 - 2.3e-23 82.0 8.4 2.3e-23 82.0 5.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.7 ESL05803.1 - 2.2e-10 40.6 0.0 3.4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 ESL05803.1 - 0.0001 21.0 0.3 0.0022 16.5 0.0 2.0 2 0 0 2 2 2 2 Peptidase C1-like family AAA_28 PF13521.1 ESL05804.1 - 2.6e-06 27.4 0.0 2.6e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain U79_P34 PF03064.11 ESL05804.1 - 0.53 9.7 8.6 1.2 8.6 6.0 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 FancD2 PF14631.1 ESL05804.1 - 7.8 3.4 6.5 11 3.0 4.5 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Ion_trans PF00520.26 ESL05805.1 - 9e-105 348.2 95.6 5.3e-34 117.2 8.8 5.1 5 0 0 5 5 5 4 Ion transport protein Na_trans_assoc PF06512.8 ESL05805.1 - 0.46 10.4 0.1 1.3 8.9 0.1 1.8 1 0 0 1 1 1 0 Sodium ion transport-associated DRIM PF07539.7 ESL05809.1 - 0.012 15.0 0.1 0.031 13.6 0.1 1.6 1 0 0 1 1 1 0 Down-regulated in metastasis DEAD PF00270.24 ESL05810.1 - 6.7e-39 133.0 0.0 4.6e-38 130.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase GUCT PF08152.7 ESL05810.1 - 1.8e-25 88.7 0.0 3.4e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 GUCT (NUC152) domain Helicase_C PF00271.26 ESL05810.1 - 1.4e-23 82.5 0.0 2.8e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL05810.1 - 0.0067 16.2 0.1 0.16 11.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PI3_PI4_kinase PF00454.22 ESL05811.1 - 2.4e-40 138.4 0.0 2.3e-39 135.2 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 ESL05811.1 - 1e-09 37.6 0.8 2.5e-09 36.3 0.2 2.1 2 0 0 2 2 2 1 FATC domain UPF0242 PF06785.6 ESL05811.1 - 0.28 9.7 0.8 0.48 9.0 0.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) DUF1917 PF08939.5 ESL05811.1 - 0.31 10.7 1.0 0.76 9.4 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) Cyt-b5 PF00173.23 ESL05812.1 - 1.2e-20 73.0 0.0 1.6e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rhabdo_glycop PF00974.13 ESL05813.1 - 0.025 12.8 0.1 0.035 12.3 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein LAT PF15234.1 ESL05813.1 - 0.039 13.4 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Linker for activation of T-cells DUF3481 PF11980.3 ESL05813.1 - 0.14 11.9 0.1 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) DUF4381 PF14316.1 ESL05813.1 - 0.16 12.0 0.3 0.27 11.3 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) Prominin PF05478.6 ESL05813.1 - 0.35 8.3 2.0 0.44 8.0 1.4 1.0 1 0 0 1 1 1 0 Prominin BNR_3 PF13859.1 ESL05815.1 - 1.3e-69 234.6 0.6 1.9e-69 234.1 0.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL05815.1 - 2.5e-18 66.3 0.3 8.6e-18 64.5 0.2 1.9 1 1 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESL05815.1 - 7e-15 55.5 0.1 7e-15 55.5 0.1 2.5 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESL05815.1 - 1.3e-05 24.3 12.1 0.26 11.2 0.2 4.9 4 0 0 4 4 4 3 BNR/Asp-box repeat Peptidase_M24 PF00557.19 ESL05817.1 - 1.4e-41 142.3 0.1 1.8e-41 142.0 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-MYND PF01753.13 ESL05817.1 - 0.00015 21.5 6.2 0.00036 20.3 4.3 1.7 1 0 0 1 1 1 1 MYND finger DUF3331 PF11811.3 ESL05820.1 - 0.43 10.1 7.4 5.3 6.7 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3331) Thioredoxin PF00085.15 ESL05821.1 - 4.6e-24 84.0 0.0 7.7e-24 83.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin ERp29 PF07749.7 ESL05821.1 - 8.9e-15 55.1 0.8 1.7e-14 54.2 0.6 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.1 ESL05821.1 - 2.7e-09 37.2 0.3 1.4e-08 34.9 0.1 2.2 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESL05821.1 - 2.1e-06 27.6 0.0 4.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 ESL05821.1 - 2.9e-06 27.2 0.1 0.0025 17.8 0.0 2.7 1 1 1 2 2 2 2 Thioredoxin-like Redoxin PF08534.5 ESL05821.1 - 0.00023 20.7 0.0 0.00043 19.8 0.0 1.5 1 0 0 1 1 1 1 Redoxin Put_DNA-bind_N PF06971.8 ESL05821.1 - 0.0075 16.0 0.2 0.16 11.7 0.0 2.8 3 1 0 3 3 3 1 Putative DNA-binding protein N-terminus TraF PF13728.1 ESL05821.1 - 0.026 13.9 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_9 PF14595.1 ESL05821.1 - 0.039 13.5 0.0 0.094 12.2 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.16 ESL05821.1 - 0.055 13.1 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 AhpC/TSA family GAT PF03127.9 ESL05821.1 - 0.078 12.9 0.4 9.2 6.3 0.0 2.5 2 1 0 2 2 2 0 GAT domain Glutaredoxin PF00462.19 ESL05821.1 - 0.085 12.8 0.1 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 Glutaredoxin IZUMO PF15005.1 ESL05821.1 - 0.19 11.7 0.7 0.4 10.7 0.1 1.7 2 0 0 2 2 2 0 Izumo sperm-egg fusion PP28 PF10252.4 ESL05821.1 - 2 8.4 7.2 0.94 9.5 0.7 2.3 1 1 1 2 2 2 0 Casein kinase substrate phosphoprotein PP28 PqiA PF04403.8 ESL05824.1 - 3.6e-13 49.4 11.6 3.6e-13 49.4 8.0 3.6 2 1 1 3 3 3 2 Paraquat-inducible protein A TMEM237 PF15383.1 ESL05824.1 - 0.1 11.7 0.2 0.1 11.7 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 237 PsbR PF04725.7 ESL05824.1 - 2.1 8.3 4.4 1.4 9.0 0.2 2.3 2 0 0 2 2 2 0 Photosystem II 10 kDa polypeptide PsbR Ribosomal_S30 PF04758.9 ESL05825.1 - 3.7e-28 97.0 8.0 4.2e-28 96.8 5.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 SKIP_SNW PF02731.10 ESL05826.1 - 1.1e-09 37.9 4.6 1.1e-09 37.9 3.2 2.7 2 1 1 3 3 3 1 SKIP/SNW domain Amidohydro_2 PF04909.9 ESL05826.1 - 0.06 12.8 1.3 0.1 12.1 0.2 1.8 2 0 0 2 2 2 0 Amidohydrolase Macoilin PF09726.4 ESL05826.1 - 4.5 5.4 10.8 6.3 4.9 7.5 1.2 1 0 0 1 1 1 0 Transmembrane protein Pkinase PF00069.20 ESL05827.1 - 3.4e-22 78.8 0.0 6.7e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05827.1 - 1.5e-07 30.7 0.0 2.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05827.1 - 0.004 16.1 0.0 0.0091 14.9 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Y_phosphatase2 PF03162.8 ESL05829.1 - 4.1e-48 162.8 0.0 5.7e-48 162.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family 5_3_exonuc_N PF02739.11 ESL05829.1 - 0.19 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain AA_kinase PF00696.23 ESL05830.1 - 2.3e-36 125.5 0.0 4.1e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family Aldedh PF00171.17 ESL05830.1 - 0.0087 14.4 0.7 0.013 13.8 0.5 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LRR_8 PF13855.1 ESL05833.1 - 3.1e-16 58.8 9.7 3.8e-15 55.3 1.1 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ESL05833.1 - 4.9e-12 45.1 7.2 3.6e-05 23.2 0.2 4.0 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL05833.1 - 9.5e-06 24.9 12.8 0.23 11.6 0.5 6.4 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.1 ESL05833.1 - 1.9e-05 24.2 3.6 11 6.4 0.0 5.6 5 0 0 5 5 5 2 Leucine Rich repeat LRR_9 PF14580.1 ESL05833.1 - 0.00065 19.2 1.3 0.00088 18.8 0.2 1.7 2 0 0 2 2 2 1 Leucine-rich repeat LRR_7 PF13504.1 ESL05833.1 - 1 9.8 14.8 8.9 7.0 0.4 6.1 5 2 1 6 6 6 0 Leucine rich repeat COLFI PF01410.13 ESL05833.1 - 2.6 7.4 8.2 6.3 6.1 0.1 2.3 2 0 0 2 2 2 0 Fibrillar collagen C-terminal domain PIN_4 PF13638.1 ESL05834.1 - 3.5e-15 56.2 0.0 8.6e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 PIN domain Abhydrolase_6 PF12697.2 ESL05836.1 - 8e-20 71.6 0.1 1.3e-19 70.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESL05836.1 - 1.2e-19 69.9 0.1 2.5e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 ESL05836.1 - 3.5e-17 62.5 0.0 1.4e-16 60.5 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL05836.1 - 6.9e-10 38.8 0.0 6.4e-09 35.7 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESL05836.1 - 4.4e-05 22.7 0.0 0.008 15.4 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.15 ESL05836.1 - 0.00021 20.8 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 ESL05836.1 - 0.0062 16.0 0.0 0.37 10.2 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.13 ESL05836.1 - 0.0075 15.5 0.1 0.088 12.0 0.0 2.3 2 1 0 2 2 2 1 Dienelactone hydrolase family PGAP1 PF07819.8 ESL05836.1 - 0.02 14.4 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2305 PF10230.4 ESL05836.1 - 0.028 13.8 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Peptidase_S15 PF02129.13 ESL05836.1 - 0.041 13.2 0.0 0.13 11.6 0.0 1.8 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.15 ESL05836.1 - 0.085 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 ESL05836.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PhoPQ_related PF10142.4 ESL05836.1 - 0.18 10.2 0.0 0.6 8.5 0.0 1.8 3 0 0 3 3 3 0 PhoPQ-activated pathogenicity-related protein zf-CCHH PF10283.4 ESL05837.1 - 0.039 13.7 0.2 0.076 12.8 0.2 1.5 1 0 0 1 1 1 0 Zinc-finger (CX5CX6HX5H) motif Exo_endo_phos PF03372.18 ESL05838.1 - 1.5e-16 61.1 0.0 1.9e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESL05838.1 - 0.0021 17.6 0.0 0.011 15.3 0.0 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Acetyltransf_1 PF00583.19 ESL05839.1 - 9.9e-14 51.1 0.0 1.4e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL05839.1 - 1.5e-06 28.2 0.0 2e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL05839.1 - 9.9e-05 22.0 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 ESL05839.1 - 0.0011 19.1 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESL05839.1 - 0.0026 17.6 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL05839.1 - 0.0091 15.8 0.1 0.019 14.8 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Ribosomal_S27 PF01599.14 ESL05840.1 - 3.5e-21 74.7 2.8 7.1e-21 73.7 1.9 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 ESL05840.1 - 1.9e-06 27.4 1.0 1.1e-05 25.0 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESL05840.1 - 9.5e-05 21.7 0.9 0.0026 17.1 0.0 2.8 2 1 0 2 2 2 1 Ubiquitin family IBR PF01485.16 ESL05840.1 - 0.0024 17.6 0.7 0.0042 16.9 0.5 1.4 1 0 0 1 1 1 1 IBR domain G6PD_C PF02781.11 ESL05841.1 - 8.7e-99 330.0 0.0 3.9e-98 327.9 0.0 1.8 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 ESL05841.1 - 3.9e-22 79.3 0.0 6.2e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Pkinase PF00069.20 ESL05842.1 - 1.4e-54 184.9 0.0 1.7e-54 184.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05842.1 - 4.7e-35 120.8 0.0 6.4e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05842.1 - 5.6e-07 28.8 0.0 7.1e-06 25.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Uteroglobin PF01099.12 ESL05843.1 - 0.091 12.5 0.0 10 6.0 0.0 3.1 3 1 0 3 3 3 0 Uteroglobin family PI3_PI4_kinase PF00454.22 ESL05845.1 - 8.3e-41 139.9 0.1 1.7e-40 138.9 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESL05845.1 - 3.1e-15 56.0 7.8 9.6e-14 51.1 2.0 3.0 1 1 1 2 2 2 1 FAT domain FATC PF02260.15 ESL05845.1 - 4.6e-13 48.3 1.0 1.3e-12 46.8 0.7 1.9 1 0 0 1 1 1 1 FATC domain UME PF08064.8 ESL05845.1 - 0.0014 18.5 3.1 0.0021 17.9 0.9 2.4 2 0 0 2 2 2 1 UME (NUC010) domain Myb_DNA-binding PF00249.26 ESL05847.1 - 3e-18 65.5 4.3 5e-09 36.0 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESL05847.1 - 1e-15 57.5 6.3 7e-08 32.4 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ESL05847.1 - 0.002 18.2 3.7 1.5 8.9 0.0 3.7 3 0 0 3 3 3 2 Myb/SANT-like DNA-binding domain tRNA-synt_2 PF00152.15 ESL05848.1 - 2.2e-42 145.0 0.1 2.7e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Sin_N PF04801.8 ESL05849.1 - 8.3e-89 298.3 0.0 2.9e-88 296.5 0.0 1.7 2 0 0 2 2 2 1 Sin-like protein conserved region BUD22 PF09073.5 ESL05850.1 - 5e-06 25.8 15.6 6.5e-06 25.4 10.8 1.2 1 0 0 1 1 1 1 BUD22 DUF2457 PF10446.4 ESL05850.1 - 0.00061 18.6 37.3 0.0008 18.2 25.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Nop14 PF04147.7 ESL05850.1 - 0.00098 17.1 30.2 0.0013 16.7 20.9 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.7 ESL05850.1 - 0.0049 16.1 28.3 0.0061 15.8 19.6 1.2 1 0 0 1 1 1 1 SDA1 CobT PF06213.7 ESL05850.1 - 0.016 14.3 23.3 0.024 13.8 16.1 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SAPS PF04499.10 ESL05850.1 - 0.037 12.6 6.5 0.037 12.6 4.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Daxx PF03344.10 ESL05850.1 - 0.04 12.4 30.0 0.053 12.0 20.8 1.2 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESL05850.1 - 0.05 11.6 22.9 0.073 11.1 15.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.5 ESL05850.1 - 0.055 13.4 9.2 0.091 12.7 6.4 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CENP-T PF15511.1 ESL05850.1 - 0.064 12.5 18.7 0.084 12.1 13.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Ycf1 PF05758.7 ESL05850.1 - 0.064 10.9 1.2 0.074 10.7 0.9 1.0 1 0 0 1 1 1 0 Ycf1 CDC27 PF09507.5 ESL05850.1 - 0.086 12.0 10.6 0.12 11.6 7.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RRN3 PF05327.6 ESL05850.1 - 0.13 10.3 15.0 0.18 9.8 10.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF1510 PF07423.6 ESL05850.1 - 0.25 10.6 21.6 0.36 10.1 14.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) VID27 PF08553.5 ESL05850.1 - 0.37 8.9 13.8 0.44 8.6 9.5 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein DUF2201_N PF13203.1 ESL05850.1 - 0.44 9.6 6.2 0.71 8.9 4.3 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain Osteopontin PF00865.13 ESL05850.1 - 0.55 9.4 34.5 1.1 8.4 23.9 1.5 1 0 0 1 1 1 0 Osteopontin eIF-3c_N PF05470.7 ESL05850.1 - 1.2 7.1 12.6 1.7 6.6 8.8 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Utp14 PF04615.8 ESL05850.1 - 2.6 6.0 18.2 3.3 5.7 12.6 1.2 1 0 0 1 1 1 0 Utp14 protein DUF3449 PF11931.3 ESL05850.1 - 3.9 6.9 8.4 7 6.1 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Spc97_Spc98 PF04130.8 ESL05850.1 - 4.4 5.5 7.7 6.4 4.9 5.3 1.1 1 0 0 1 1 1 0 Spc97 / Spc98 family CKAP2_C PF15297.1 ESL05850.1 - 5.5 5.7 6.2 8.5 5.0 4.3 1.2 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF2796 PF10986.3 ESL05850.1 - 6 6.8 15.7 3.7 7.4 9.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) FYVE PF01363.16 ESL05851.1 - 2e-13 49.9 14.1 2.6e-13 49.6 7.5 2.5 2 1 0 2 2 2 1 FYVE zinc finger Pkinase PF00069.20 ESL05852.1 - 1.7e-33 115.9 0.0 1.7e-26 92.9 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05852.1 - 4.9e-05 22.5 0.0 1.3 8.0 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase APH PF01636.18 ESL05852.1 - 0.011 15.4 0.6 0.023 14.4 0.2 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESL05852.1 - 0.069 11.9 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 ESL05852.1 - 0.11 11.5 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3678 PF12435.3 ESL05852.1 - 7.4 6.2 9.5 0.96 9.0 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3678) PPK2 PF03976.9 ESL05853.1 - 0.044 13.0 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) CRAL_TRIO PF00650.15 ESL05854.1 - 5.9e-13 48.6 0.0 9.4e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain AhpC-TSA PF00578.16 ESL05855.1 - 4.7e-27 94.1 0.0 6.7e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.4 ESL05855.1 - 6.4e-11 41.7 0.1 1.1e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.5 ESL05855.1 - 2.1e-09 37.0 0.0 3.2e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Redoxin ABC_tran PF00005.22 ESL05858.1 - 1.5e-56 190.4 0.0 1.2e-29 103.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 ESL05858.1 - 2.1e-44 151.9 43.5 3.7e-29 101.8 12.8 3.2 3 1 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.1 ESL05858.1 - 6.4e-17 62.4 0.1 0.0017 18.3 0.0 4.2 3 1 1 4 4 4 3 AAA domain SMC_N PF02463.14 ESL05858.1 - 2.1e-07 30.3 1.5 0.022 13.9 0.1 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESL05858.1 - 3.6e-05 23.1 2.0 0.021 14.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 ESL05858.1 - 5.4e-05 23.6 0.2 0.021 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 ESL05858.1 - 0.00013 21.4 0.5 0.1 12.0 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain SbcCD_C PF13558.1 ESL05858.1 - 0.0014 18.5 0.0 1.3 9.0 0.0 3.1 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA PF00004.24 ESL05858.1 - 0.0015 18.6 0.1 2.5 8.3 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.1 ESL05858.1 - 0.0019 17.3 0.0 5.9 5.8 0.0 3.5 4 0 0 4 4 4 2 AAA ATPase domain DUF258 PF03193.11 ESL05858.1 - 0.0044 16.2 0.2 4 6.6 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_13 PF13166.1 ESL05858.1 - 0.0083 14.6 0.1 0.1 11.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESL05858.1 - 0.0088 15.6 1.7 0.48 9.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 ESL05858.1 - 0.014 15.2 0.9 1.4 8.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.1 ESL05858.1 - 0.024 14.3 1.1 1.6 8.5 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain AAA_25 PF13481.1 ESL05858.1 - 0.032 13.6 0.4 3.9 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 ESL05858.1 - 0.061 12.9 1.0 6.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_14 PF13173.1 ESL05858.1 - 0.082 12.8 0.0 18 5.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 ESL05858.1 - 0.13 12.3 2.1 8.4 6.5 0.2 3.1 2 1 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 ESL05858.1 - 0.29 10.8 0.1 0.92 9.1 0.0 1.8 2 0 0 2 2 1 0 Archaeal ATPase AAA_10 PF12846.2 ESL05858.1 - 0.32 10.3 0.5 6.5 6.0 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain Cullin_Nedd8 PF10557.4 ESL05859.1 - 1.4e-18 66.4 0.0 2.9e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.17 ESL05859.1 - 6e-06 25.0 0.0 1e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Cullin family LRR_8 PF13855.1 ESL05860.1 - 6.1e-17 61.1 14.0 4.9e-15 55.0 1.0 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ESL05860.1 - 3.1e-13 48.9 3.8 4.2e-05 23.0 0.1 4.0 2 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL05860.1 - 5.4e-05 22.6 13.5 0.3 11.2 0.5 6.4 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.1 ESL05860.1 - 6.1e-05 22.6 3.6 15 6.0 0.0 5.6 5 0 0 5 5 5 1 Leucine Rich repeat LRR_9 PF14580.1 ESL05860.1 - 0.00049 19.7 0.3 0.0012 18.4 0.2 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_7 PF13504.1 ESL05860.1 - 0.19 12.0 10.9 12 6.6 0.4 5.9 4 2 1 5 5 5 0 Leucine rich repeat COLFI PF01410.13 ESL05860.1 - 1.8 7.8 6.2 8.8 5.6 0.1 2.3 2 0 0 2 2 2 0 Fibrillar collagen C-terminal domain WD40 PF00400.27 ESL05861.1 - 6.3e-60 197.0 19.8 1.1e-11 44.1 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESL05861.1 - 1.6e-05 23.2 11.3 0.0025 16.0 0.1 4.4 2 2 2 4 4 4 2 Nucleoporin Nup120/160 DUF1513 PF07433.6 ESL05861.1 - 0.0001 21.3 0.1 0.11 11.3 0.0 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.6 ESL05861.1 - 0.0099 14.6 0.3 0.55 8.9 0.0 2.8 1 1 0 2 2 2 1 Nup133 N terminal like PD40 PF07676.7 ESL05861.1 - 0.019 14.6 0.2 19 5.0 0.0 4.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 ESL05861.1 - 0.021 13.1 0.0 0.32 9.2 0.0 2.4 2 1 1 3 3 3 0 Cytochrome D1 heme domain Pkinase PF00069.20 ESL05862.1 - 3.2e-54 183.7 0.0 4.7e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05862.1 - 8.9e-35 119.9 0.0 1.7e-34 119.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05862.1 - 1.5e-06 27.3 0.0 1.5e-05 24.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Peripla_BP_6 PF13458.1 ESL05864.1 - 9.8e-14 51.4 6.0 1.4e-13 50.9 4.2 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Pkinase PF00069.20 ESL05865.1 - 1.3e-63 214.5 0.0 1.6e-63 214.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05865.1 - 5.6e-39 133.7 0.0 7.4e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05865.1 - 5.6e-09 35.3 0.0 3.5e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL05865.1 - 0.0003 20.6 0.2 0.00091 19.0 0.1 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESL05865.1 - 0.022 13.5 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 PDEase_I PF00233.14 ESL05866.1 - 1.7e-13 50.8 0.0 2.6e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DnaJ PF00226.26 ESL05867.1 - 1.2e-14 53.7 0.8 2.1e-14 52.9 0.6 1.4 1 0 0 1 1 1 1 DnaJ domain AAA_17 PF13207.1 ESL05867.1 - 0.21 12.3 1.1 3.5 8.4 0.0 2.6 2 2 0 2 2 2 0 AAA domain DUF3666 PF12408.3 ESL05867.1 - 0.22 10.6 1.2 3.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase Pkinase PF00069.20 ESL05869.1 - 2.5e-55 187.4 0.0 1.4e-35 122.6 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05869.1 - 1.6e-30 106.0 0.0 2.4e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05869.1 - 9.9e-06 24.7 0.0 1.7e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Tbf5 PF06331.7 ESL05869.1 - 0.2 11.4 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 HA2 PF04408.18 ESL05870.1 - 5.8e-05 23.0 0.0 0.00017 21.5 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) PPR_3 PF13812.1 ESL05871.1 - 5.4e-12 44.9 0.2 1.8e-05 24.6 0.0 4.4 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.15 ESL05871.1 - 4.6e-11 41.9 0.1 0.0095 15.8 0.0 4.9 5 0 0 5 5 5 4 PPR repeat PPR_2 PF13041.1 ESL05871.1 - 7.6e-11 41.8 0.0 4.6e-05 23.3 0.0 3.8 2 1 2 4 4 4 3 PPR repeat family dsrm PF00035.20 ESL05872.1 - 0.0022 18.5 0.0 3.9 8.1 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif FAD_binding_2 PF00890.19 ESL05872.1 - 0.11 11.2 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Peripla_BP_6 PF13458.1 ESL05872.1 - 0.2 10.9 0.0 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Periplasmic binding protein GCD14 PF08704.5 ESL05874.1 - 5.2e-26 91.6 0.0 2.1e-23 83.1 0.0 2.1 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 ESL05874.1 - 0.056 13.0 0.0 0.073 12.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain KMP11 PF03037.11 ESL05875.1 - 2e-56 188.5 17.0 2.2e-56 188.4 11.8 1.0 1 0 0 1 1 1 1 Kinetoplastid membrane protein 11 Apolipoprotein PF01442.13 ESL05875.1 - 0.0068 15.9 3.3 0.016 14.7 2.3 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain AAA_32 PF13654.1 ESL05875.1 - 0.012 14.3 3.6 0.013 14.2 2.5 1.0 1 0 0 1 1 1 0 AAA domain FCH PF00611.18 ESL05875.1 - 0.012 15.7 1.0 0.012 15.7 0.7 1.9 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Lyase_8_N PF08124.6 ESL05875.1 - 0.021 13.6 1.7 0.022 13.6 1.2 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF3584 PF12128.3 ESL05875.1 - 0.058 10.7 4.0 0.07 10.4 2.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TroA PF01297.12 ESL05875.1 - 0.075 12.2 1.8 2.2 7.4 0.1 2.0 1 1 1 2 2 2 0 Periplasmic solute binding protein family Brr6_like_C_C PF10104.4 ESL05875.1 - 0.086 12.3 0.5 0.093 12.2 0.3 1.1 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Metal_resist PF13801.1 ESL05875.1 - 0.099 12.6 1.3 0.32 10.9 0.2 1.9 1 1 1 2 2 2 0 Heavy-metal resistance THP2 PF09432.5 ESL05875.1 - 0.11 12.3 1.6 0.13 12.0 1.1 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 FliD_C PF07195.7 ESL05875.1 - 0.15 11.3 1.9 0.23 10.7 1.3 1.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus T5orf172 PF10544.4 ESL05875.1 - 0.17 12.2 2.2 0.2 12.0 1.5 1.2 1 0 0 1 1 1 0 T5orf172 domain Mating_N PF12731.2 ESL05875.1 - 0.17 11.7 1.2 0.25 11.2 0.8 1.3 1 0 0 1 1 1 0 Mating-type protein beta 1 GrpE PF01025.14 ESL05875.1 - 0.21 11.1 5.5 0.22 11.0 3.8 1.1 1 0 0 1 1 1 0 GrpE DIOX_N PF14226.1 ESL05875.1 - 0.32 11.5 4.6 0.38 11.2 3.2 1.1 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal DUF4404 PF14357.1 ESL05875.1 - 0.34 11.3 3.5 1.1 9.6 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) NYD-SP28 PF14772.1 ESL05875.1 - 0.44 10.6 6.7 4.1 7.5 0.2 2.4 2 1 0 2 2 2 0 Sperm tail ARL2_Bind_BART PF11527.3 ESL05875.1 - 0.52 10.1 9.1 0.85 9.4 6.3 1.3 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART YlqD PF11068.3 ESL05875.1 - 0.56 10.2 6.8 1.2 9.1 4.7 1.5 1 1 0 1 1 1 0 YlqD protein Vps54 PF07928.7 ESL05875.1 - 0.83 9.7 3.7 0.56 10.3 1.2 1.6 2 0 0 2 2 2 0 Vps54-like protein DUF2884 PF11101.3 ESL05875.1 - 1.1 8.5 8.3 2 7.7 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) Mitofilin PF09731.4 ESL05875.1 - 9.2 4.7 10.4 11 4.5 7.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Pkinase PF00069.20 ESL05876.1 - 2.2e-34 118.8 0.0 2.7e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05876.1 - 3.3e-15 55.8 0.0 3.8e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL05876.1 - 3.3e-06 26.9 0.0 0.00073 19.3 0.0 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL05876.1 - 0.013 14.5 0.2 0.028 13.5 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL05876.1 - 0.041 12.8 0.0 0.2 10.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESL05876.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ribosomal_L1 PF00687.16 ESL05877.1 - 8.4e-33 113.5 2.3 9.2e-33 113.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Antimicrobial_4 PF08024.6 ESL05877.1 - 1.2 9.0 3.6 2.2 8.2 0.4 2.4 2 0 0 2 2 2 0 Ant antimicrobial peptide IRK PF01007.15 ESL05879.1 - 0.00075 18.3 0.1 0.00075 18.3 0.1 3.0 2 2 0 2 2 2 1 Inward rectifier potassium channel DUF3595 PF12166.3 ESL05881.1 - 1.7e-112 376.3 0.2 1.3e-111 373.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3595) Galactosyl_T PF01762.16 ESL05882.1 - 3e-09 36.7 0.0 0.00077 19.1 0.0 3.2 2 1 1 3 3 3 2 Galactosyltransferase Gp_dh_C PF02800.15 ESL05883.1 - 9.9e-73 242.7 0.1 1.4e-72 242.3 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL05883.1 - 1.2e-61 207.1 0.2 2.2e-61 206.2 0.2 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 ESL05883.1 - 9e-05 22.3 2.8 0.00065 19.6 0.9 2.8 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.14 ESL05883.1 - 0.09 11.9 0.1 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.17 ESL05883.1 - 0.094 13.2 0.1 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Tr-sialidase_C PF11052.3 ESL05884.1 - 5.1e-05 23.0 8.1 9.9e-05 22.1 5.6 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MFS_1 PF07690.11 ESL05885.1 - 2.6e-08 32.9 29.8 2.6e-08 32.9 20.6 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF1673 PF07895.6 ESL05885.1 - 0.84 9.1 5.4 0.48 9.9 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) RabGAP-TBC PF00566.13 ESL05886.1 - 1.1e-58 198.2 0.1 1.4e-58 197.9 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HECT PF00632.20 ESL05887.1 - 3.9e-70 236.5 0.0 6.2e-70 235.8 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) GST_C PF00043.20 ESL05888.1 - 4.2e-15 55.5 0.1 9.1e-15 54.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESL05888.1 - 3.9e-11 42.9 0.0 8.7e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESL05888.1 - 7.7e-07 29.5 0.2 1.5e-06 28.5 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESL05888.1 - 1.7e-06 28.1 0.0 3.5e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESL05888.1 - 1.4e-05 24.8 1.3 2.6e-05 24.0 0.9 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESL05888.1 - 0.0049 16.8 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain EF1G PF00647.14 ESL05888.1 - 0.022 14.4 0.0 0.15 11.8 0.1 2.1 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain MYCBPAP PF14646.1 ESL05890.1 - 2.2e-06 26.6 2.5 0.41 9.2 0.0 6.1 8 0 0 8 8 8 2 MYCBP-associated protein family AAA_17 PF13207.1 ESL05890.1 - 0.00012 22.8 0.0 0.00033 21.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL05890.1 - 0.0016 18.4 0.1 0.0043 17.0 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain ADK PF00406.17 ESL05890.1 - 0.0021 17.9 0.0 0.0042 16.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase AAA_22 PF13401.1 ESL05890.1 - 0.0021 18.2 0.1 0.0055 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESL05890.1 - 0.009 15.9 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESL05890.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase NB-ARC PF00931.17 ESL05890.1 - 0.032 13.0 0.0 0.059 12.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain KTI12 PF08433.5 ESL05890.1 - 0.037 13.2 0.0 0.068 12.3 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.1 ESL05890.1 - 0.042 13.7 0.0 0.095 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 ESL05891.1 - 1.5e-42 145.5 0.0 2.2e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05891.1 - 7.5e-24 84.1 0.0 1.1e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESL05891.1 - 2.8e-13 49.5 12.2 9.3e-13 47.8 8.5 2.0 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESL05891.1 - 0.00055 19.7 0.0 0.00095 18.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESL05891.1 - 0.0017 17.7 0.1 0.0026 17.1 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 ESL05891.1 - 0.092 12.3 0.1 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Dynein_heavy PF03028.10 ESL05892.1 - 1.3e-214 714.3 0.0 5.5e-214 712.2 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 ESL05892.1 - 2.4e-143 478.6 0.8 1.6e-142 475.8 0.0 2.9 2 1 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 ESL05892.1 - 9.1e-119 396.5 8.4 9.1e-119 396.5 5.8 4.1 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESL05892.1 - 1.4e-100 335.6 0.0 2.7e-100 334.6 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESL05892.1 - 3.3e-74 249.2 0.0 5.7e-74 248.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.2 ESL05892.1 - 4.2e-53 180.1 0.0 1.5e-52 178.3 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_9 PF12781.2 ESL05892.1 - 7.8e-48 162.2 0.0 1.8e-47 161.0 0.0 1.7 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESL05892.1 - 5.7e-40 137.1 9.7 1.2e-39 136.0 6.7 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESL05892.1 - 1.9e-27 95.6 2.7 7e-07 29.0 0.0 7.0 6 1 0 6 6 5 4 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESL05892.1 - 2.2e-08 34.3 0.1 0.72 10.0 0.0 6.2 6 0 0 6 6 5 2 AAA domain DUF258 PF03193.11 ESL05892.1 - 4.1e-07 29.3 0.3 0.0019 17.3 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA PF00004.24 ESL05892.1 - 1.3e-06 28.6 4.2 0.87 9.7 0.0 5.7 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 ESL05892.1 - 1.3e-05 25.5 2.4 0.4 10.9 0.0 4.5 4 0 0 4 4 3 1 ABC transporter AAA_17 PF13207.1 ESL05892.1 - 1.4e-05 25.8 0.0 3.7 8.3 0.0 5.4 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.1 ESL05892.1 - 1.8e-05 24.8 17.3 0.15 12.0 0.0 7.5 8 1 0 8 8 6 2 AAA ATPase domain AAA_30 PF13604.1 ESL05892.1 - 0.00012 21.6 5.7 0.48 9.9 0.0 4.4 5 0 0 5 5 4 1 AAA domain T2SE PF00437.15 ESL05892.1 - 0.00042 19.3 4.0 0.51 9.1 0.0 3.7 4 0 0 4 4 4 2 Type II/IV secretion system protein Sigma54_activat PF00158.21 ESL05892.1 - 0.0015 18.0 0.1 0.56 9.6 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_19 PF13245.1 ESL05892.1 - 0.0046 16.6 0.2 13 5.6 0.0 4.5 4 0 0 4 4 4 0 Part of AAA domain AAA_29 PF13555.1 ESL05892.1 - 0.0063 16.0 0.1 1 8.9 0.0 3.3 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_33 PF13671.1 ESL05892.1 - 0.0079 16.0 0.7 6.4 6.6 0.0 4.9 6 0 0 6 6 4 0 AAA domain RNA_helicase PF00910.17 ESL05892.1 - 0.0084 16.2 0.1 6.2 7.0 0.0 3.7 3 0 0 3 3 3 0 RNA helicase MobB PF03205.9 ESL05892.1 - 0.028 14.1 1.3 3.8 7.1 0.1 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ESL05892.1 - 0.038 13.4 0.9 0.27 10.6 0.0 3.0 3 0 0 3 3 3 0 AAA-like domain MMR_HSR1 PF01926.18 ESL05892.1 - 0.32 10.9 0.8 2.4 8.1 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL05892.1 - 0.74 9.6 3.2 3.7 7.3 0.0 3.0 2 0 0 2 2 2 0 Dynamin family Gon7 PF08738.5 ESL05892.1 - 3.1 7.8 8.7 8.5 6.4 0.1 3.1 2 0 0 2 2 2 0 Gon7 family AAA PF00004.24 ESL05893.1 - 7e-36 123.3 0.0 1.4e-35 122.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESL05893.1 - 8.7e-05 21.6 0.1 0.00066 18.8 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESL05893.1 - 0.0024 18.0 0.0 0.028 14.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL05893.1 - 0.0059 15.3 0.0 0.0092 14.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 ESL05893.1 - 0.015 15.1 0.1 0.16 11.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ESL05893.1 - 0.02 15.7 0.0 0.037 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 ESL05893.1 - 0.022 14.4 0.1 0.086 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 ESL05893.1 - 0.028 13.8 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESL05893.1 - 0.19 10.9 0.0 0.19 10.9 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 ESL05893.1 - 0.23 11.0 0.0 0.43 10.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Njmu-R1 PF15053.1 ESL05894.1 - 0.057 12.1 0.0 0.094 11.4 0.0 1.4 1 0 0 1 1 1 0 Mjmu-R1-like protein family Vps5 PF09325.5 ESL05894.1 - 0.25 10.5 8.4 3.4 6.8 0.1 2.0 2 0 0 2 2 2 0 Vps5 C terminal like IncA PF04156.9 ESL05894.1 - 0.9 9.1 7.6 2.7 7.5 2.9 2.1 2 0 0 2 2 2 0 IncA protein Mem_trans PF03547.13 ESL05895.1 - 6.4e-10 37.8 3.1 8.4e-10 37.4 2.1 1.1 1 0 0 1 1 1 1 Membrane transport protein Gemini_mov PF01708.11 ESL05895.1 - 0.88 9.1 2.7 1.3 8.6 0.6 1.9 2 0 0 2 2 2 0 Geminivirus putative movement protein FAT PF02259.18 ESL05896.1 - 3.6e-27 95.2 8.6 5.2e-27 94.7 5.1 2.0 2 1 0 2 2 2 1 FAT domain KNOX2 PF03791.8 ESL05896.1 - 0.068 12.4 0.3 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 KNOX2 domain cNMP_binding PF00027.24 ESL05897.1 - 1.6e-22 79.1 0.0 6.2e-14 51.5 0.0 3.2 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain C2 PF00168.25 ESL05897.1 - 3.1e-11 42.9 0.0 0.018 14.8 0.0 4.5 4 0 0 4 4 4 4 C2 domain Viral_helicase1 PF01443.13 ESL05898.1 - 0.0046 16.4 0.0 0.0089 15.5 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Miro PF08477.8 ESL05898.1 - 0.02 15.3 0.0 0.19 12.2 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein AAA_16 PF13191.1 ESL05898.1 - 0.022 14.7 0.0 0.086 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.18 ESL05898.1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Dynamin family MMR_HSR1 PF01926.18 ESL05898.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 ESL05898.1 - 0.066 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESL05898.1 - 0.08 13.0 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESL05898.1 - 0.16 10.8 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_32 PF13654.1 ESL05898.1 - 0.38 9.3 0.0 0.57 8.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESL05898.1 - 0.59 9.8 0.0 1.1 9.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 DUF3096 PF11295.3 ESL05899.1 - 8.2 6.0 15.0 1.1 8.8 1.4 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3096) 4HBT PF03061.17 ESL05900.1 - 0.00091 19.3 0.1 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 ESL05900.1 - 0.0049 16.6 0.1 0.015 15.0 0.1 1.7 1 1 1 2 2 2 2 Thioesterase-like superfamily Rad51 PF08423.6 ESL05901.1 - 1.6e-28 99.3 0.2 8.2e-20 70.7 0.0 4.1 4 0 0 4 4 4 3 Rad51 AAA_25 PF13481.1 ESL05901.1 - 6e-12 45.3 0.0 4e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 ESL05901.1 - 3.3e-06 26.3 0.0 4.9e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 KaiC RecA PF00154.16 ESL05901.1 - 8.2e-05 21.8 0.0 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_19 PF13245.1 ESL05901.1 - 0.0068 16.1 0.0 0.069 12.9 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA PF00004.24 ESL05901.1 - 0.023 14.9 0.0 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ESL05901.1 - 0.028 14.3 0.1 0.085 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain Septum_form PF13845.1 ESL05901.1 - 0.033 13.7 0.3 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 Septum formation AAA_22 PF13401.1 ESL05901.1 - 0.051 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESL05901.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Hydrolase_6 PF13344.1 ESL05902.1 - 3.9e-19 68.3 0.0 7.8e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESL05902.1 - 4.1e-15 55.2 0.0 1e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ESL05902.1 - 5.3e-08 33.5 0.0 0.013 15.9 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESL05902.1 - 9.7e-06 25.9 0.0 0.0017 18.6 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 ESL05902.1 - 5.8e-05 22.5 0.0 0.00014 21.2 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase DSPc PF00782.15 ESL05903.1 - 9.6e-20 70.5 0.0 1.4e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ESSS PF10183.4 ESL05904.1 - 1.1e-14 54.7 3.8 1.2e-14 54.5 2.7 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Peptidase_M20 PF01546.23 ESL05905.1 - 5.1e-13 48.9 0.1 6.1e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL05905.1 - 2.7e-08 33.5 0.1 4.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.9 ESL05905.1 - 0.0002 20.2 0.1 0.0033 16.2 0.0 2.2 2 1 0 2 2 2 1 M42 glutamyl aminopeptidase ATP-synt_ab PF00006.20 ESL05906.1 - 4.3e-66 222.4 0.1 5.6e-66 222.1 0.1 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL05906.1 - 0.0057 17.1 0.1 0.022 15.2 0.0 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain Carn_acyltransf PF00755.15 ESL05907.1 - 2.2e-38 131.7 0.5 2.8e-38 131.3 0.4 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase AAA PF00004.24 ESL05908.1 - 3.7e-39 133.9 0.0 2e-36 125.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL05908.1 - 5.3e-06 26.5 2.5 0.0049 16.8 0.0 3.8 3 2 1 4 4 4 1 AAA ATPase domain AAA_14 PF13173.1 ESL05908.1 - 0.0031 17.4 0.0 0.014 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESL05908.1 - 0.0038 16.9 0.1 0.036 13.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESL05908.1 - 0.0075 17.0 0.0 0.018 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESL05908.1 - 0.02 14.3 0.0 1.2 8.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.9 ESL05908.1 - 0.035 14.0 0.0 0.091 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL05908.1 - 0.041 14.0 0.0 2.6 8.1 0.0 2.8 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.10 ESL05908.1 - 0.061 12.0 0.0 0.097 11.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 ESL05908.1 - 0.08 12.6 0.0 8.9 5.9 0.0 2.7 2 1 1 3 3 3 0 Archaeal ATPase Mg_chelatase PF01078.16 ESL05908.1 - 0.13 11.4 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 ESL05908.1 - 0.17 10.8 0.0 0.31 9.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Ribosomal_L34e PF01199.13 ESL05909.1 - 2.6e-29 101.3 4.6 2.6e-29 101.3 3.2 2.3 2 1 0 2 2 2 1 Ribosomal protein L34e DUF2762 PF10960.3 ESL05909.1 - 7.7 6.3 7.5 14 5.5 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) Aa_trans PF01490.13 ESL05910.1 - 5.5e-33 114.0 21.9 6e-33 113.9 15.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Cytochrom_B_C PF00032.12 ESL05910.1 - 0.12 12.5 0.4 0.12 12.5 0.3 3.3 2 1 2 4 4 4 0 Cytochrome b(C-terminal)/b6/petD RHSP PF07999.6 ESL05911.1 - 1.6e-77 260.9 0.1 2.3e-77 260.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESL05911.1 - 0.052 12.9 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 ESL05911.1 - 0.13 12.3 0.0 0.89 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain DZR PF12773.2 ESL05912.1 - 4.1e-09 36.1 62.6 0.00041 20.1 7.0 7.3 5 3 1 6 6 6 5 Double zinc ribbon RRM_1 PF00076.17 ESL05913.1 - 2.1e-10 40.0 0.0 3.5e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL05913.1 - 7.4e-09 35.4 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL05913.1 - 4.3e-07 29.6 0.0 8e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESL05913.1 - 1.1e-05 25.2 0.3 2.8e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 RNA binding motif Limkain-b1 PF11608.3 ESL05913.1 - 0.0021 17.7 0.0 0.0036 17.0 0.0 1.4 1 1 0 1 1 1 1 Limkain b1 NID PF07292.8 ESL05913.1 - 0.062 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Nmi/IFP 35 domain (NID) SPOR PF05036.8 ESL05913.1 - 0.11 12.6 0.0 0.62 10.2 0.0 2.2 1 1 1 2 2 2 0 Sporulation related domain DREPP PF05558.7 ESL05913.1 - 0.18 11.6 1.1 0.52 10.1 0.8 1.8 1 1 0 1 1 1 0 DREPP plasma membrane polypeptide Glyco_transf_28 PF03033.15 ESL05915.1 - 0.053 13.2 0.1 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain DUF2962 PF11176.3 ESL05916.1 - 1.8e-30 105.5 0.0 1.8e-30 105.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2962) PipA PF07108.6 ESL05918.1 - 0.045 13.1 0.1 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 PipA protein DUF2096 PF09869.4 ESL05918.1 - 6.5 6.6 9.2 0.35 10.7 0.1 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) PEPCK_ATP PF01293.15 ESL05920.1 - 5.1e-156 519.8 0.0 6e-156 519.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 ESL05920.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESL05920.1 - 0.04 13.8 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.1 ESL05920.1 - 0.073 12.4 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESL05920.1 - 0.13 11.8 0.1 0.29 10.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DGF-1_5 PF11038.3 ESL05922.1 - 4.9e-71 239.1 13.9 7.7e-71 238.5 9.6 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL05922.1 - 4.2e-22 77.8 0.2 1.1e-21 76.4 0.1 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4227 PF14004.1 ESL05922.1 - 0.0051 16.6 0.0 0.016 15.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4227) Pkinase PF00069.20 ESL05923.1 - 6.1e-42 143.5 0.0 1.4e-27 96.5 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05923.1 - 1.2e-18 67.1 0.0 3.3e-10 39.4 0.1 3.3 3 1 0 3 3 3 2 Protein tyrosine kinase APH PF01636.18 ESL05923.1 - 0.0011 18.8 0.0 0.012 15.3 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL05923.1 - 0.0016 17.5 0.0 0.0035 16.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL05923.1 - 0.0043 16.0 0.1 0.056 12.4 0.0 2.5 3 0 0 3 3 3 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESL05923.1 - 0.096 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL NCD1 PF04904.8 ESL05923.1 - 0.13 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) FA_desaturase PF00487.19 ESL05924.1 - 7.3e-26 91.1 34.0 9.6e-26 90.7 23.6 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Peptidase_M8 PF01457.11 ESL05925.1 - 3.3e-115 385.4 0.0 4.3e-115 385.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESL05925.1 - 0.0045 16.9 0.0 0.0072 16.2 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M57 PF12388.3 ESL05925.1 - 0.0081 15.5 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.1 ESL05925.1 - 0.02 15.4 0.2 0.042 14.3 0.0 1.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.19 ESL05925.1 - 0.029 13.7 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.1 ESL05925.1 - 0.099 12.6 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like HECT PF00632.20 ESL05926.1 - 9.3e-71 238.5 0.0 2.5e-70 237.1 0.0 1.7 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF1930 PF09122.5 ESL05927.1 - 1.4e-23 82.4 0.3 1.1e-22 79.5 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1930) Rhodanese PF00581.15 ESL05927.1 - 7.4e-19 68.1 0.0 2e-11 44.2 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Peptidase_C97 PF05903.9 ESL05928.1 - 2.7e-24 85.6 0.2 4.3e-24 85.0 0.1 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 ESL05928.1 - 0.0093 15.9 0.1 0.025 14.5 0.1 1.7 1 0 0 1 1 1 1 Lecithin retinol acyltransferase ubiquitin PF00240.18 ESL05929.1 - 0.047 13.0 0.0 0.088 12.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Hydrolase PF00702.21 ESL05930.1 - 3.3e-18 66.8 0.0 4.5e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 ESL05930.1 - 4.1e-18 65.5 0.0 6.2e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus HAD PF12710.2 ESL05930.1 - 2.6e-06 27.7 0.0 3.7e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL05930.1 - 5.9e-06 26.0 0.0 0.00024 20.7 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase bcl-2I13 PF12201.3 ESL05930.1 - 0.05 13.0 2.2 1.9 7.9 0.1 2.4 1 1 1 2 2 2 0 Bcl2-interacting killer, BH3-domain containing UPF0066 PF01980.11 ESL05931.1 - 5.6e-30 103.7 0.0 1.3e-29 102.6 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family UPF0066 PWWP PF00855.12 ESL05931.1 - 4.3e-05 23.6 0.2 0.0001 22.4 0.1 1.7 1 1 0 1 1 1 1 PWWP domain EmrE PF13536.1 ESL05931.1 - 0.087 13.0 3.1 0.11 12.6 0.6 2.0 2 0 0 2 2 2 0 Multidrug resistance efflux transporter Rho_RNA_bind PF07497.7 ESL05931.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Rho termination factor, RNA-binding domain Gp_dh_C PF02800.15 ESL05933.1 - 6.9e-30 103.5 0.1 7.9e-30 103.3 0.0 1.0 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain F_bP_aldolase PF01116.15 ESL05933.1 - 0.037 13.1 0.1 0.046 12.8 0.0 1.1 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II ACC_central PF08326.7 ESL05934.1 - 2.7e-104 349.7 0.0 1.5e-96 324.1 0.0 2.1 2 0 0 2 2 2 2 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.12 ESL05934.1 - 5.7e-47 159.7 0.0 1.8e-46 158.1 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESL05934.1 - 9.6e-23 80.3 0.0 2.5e-22 79.0 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESL05934.1 - 1.6e-21 76.2 0.0 5.5e-21 74.5 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 ESL05934.1 - 5.7e-12 45.7 0.0 1.2e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 ESL05934.1 - 4e-10 39.1 0.0 9e-10 38.0 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 ESL05934.1 - 3.2e-09 36.0 0.0 1.2e-05 24.2 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 ESL05934.1 - 0.00012 21.5 0.0 0.00027 20.3 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 ESL05934.1 - 0.00079 18.8 0.0 0.0022 17.3 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESL05934.1 - 0.064 12.9 0.0 0.29 10.8 0.0 2.0 2 0 0 2 2 2 0 Biotin-lipoyl like BAAT_C PF08840.6 ESL05934.1 - 0.072 12.7 0.0 5.8 6.5 0.0 3.0 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal ATPgrasp_ST PF14397.1 ESL05934.1 - 0.3 10.1 0.0 0.6 9.1 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp CesT PF05932.8 ESL05935.1 - 1.8e-16 60.0 2.2 2e-16 59.9 0.7 1.7 2 0 0 2 2 2 1 Tir chaperone protein (CesT) family ubiquitin PF00240.18 ESL05935.1 - 2e-07 30.3 0.1 6.2e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESL05935.1 - 0.0019 17.8 0.1 0.0045 16.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF3437 PF11919.3 ESL05936.1 - 4.8e-18 64.6 0.0 1.6e-17 63.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) Histone PF00125.19 ESL05937.1 - 1.7e-18 66.4 0.1 2.7e-18 65.8 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF3413 PF11893.3 ESL05937.1 - 0.077 11.8 4.2 0.13 11.1 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) NUC194 PF08163.7 ESL05938.1 - 4.6e-17 61.9 0.0 3.1e-08 32.9 0.0 2.2 2 0 0 2 2 2 2 NUC194 domain DUF4003 PF13170.1 ESL05938.1 - 2.1 7.5 0.0 4.6 6.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) PPK2 PF03976.9 ESL05940.1 - 0.058 12.6 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) Syja_N PF02383.13 ESL05942.1 - 5.4e-72 242.2 0.0 9e-72 241.5 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain DUF547 PF04784.9 ESL05942.1 - 3.9e-13 49.2 0.0 8.2e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF547 TPR_11 PF13414.1 ESL05943.1 - 1.1e-05 24.9 0.1 2.3e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 TPR repeat TPR_9 PF13371.1 ESL05943.1 - 0.00093 19.0 2.4 0.001 18.8 0.3 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.3 ESL05943.1 - 0.048 12.4 0.0 0.083 11.6 0.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_14 PF13428.1 ESL05943.1 - 2.1 9.2 5.3 0.42 11.3 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL05945.1 - 3.3e-16 59.2 0.0 7.2e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05945.1 - 1.7e-10 40.4 0.0 4e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05945.1 - 0.0015 17.5 0.0 0.003 16.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.27 ESL05946.1 - 4.1e-13 48.6 14.0 0.0031 17.3 0.0 8.1 8 0 0 8 8 8 3 WD domain, G-beta repeat DUF3832 PF12909.2 ESL05946.1 - 0.016 15.2 0.0 0.054 13.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3832) Citrate_synt PF00285.16 ESL05947.1 - 6.3e-89 298.1 0.0 7e-89 298.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase Ras PF00071.17 ESL05948.1 - 5.2e-57 191.7 0.1 6.1e-57 191.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL05948.1 - 8.6e-23 81.0 0.1 1.2e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL05948.1 - 1.4e-15 57.0 0.1 1.7e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL05948.1 - 3.7e-06 26.2 0.0 4.4e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL05948.1 - 1.8e-05 24.6 0.0 2.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESL05948.1 - 0.00036 20.6 0.0 0.0013 18.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESL05948.1 - 0.00085 18.5 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ESL05948.1 - 0.00097 19.1 0.1 0.0011 18.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.22 ESL05948.1 - 0.0011 18.3 0.1 0.0047 16.3 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESL05948.1 - 0.0063 15.7 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 PduV-EutP PF10662.4 ESL05948.1 - 0.0078 15.7 0.0 0.015 14.7 0.0 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.13 ESL05948.1 - 0.0089 15.0 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_24 PF13479.1 ESL05948.1 - 0.012 15.2 0.1 0.036 13.6 0.1 1.8 1 1 1 2 2 2 0 AAA domain NACHT PF05729.7 ESL05948.1 - 0.025 14.2 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain MCM PF00493.18 ESL05948.1 - 0.031 13.0 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family ABC_tran PF00005.22 ESL05948.1 - 0.031 14.5 0.1 0.046 14.0 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 ESL05948.1 - 0.053 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.8 ESL05948.1 - 0.056 12.3 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.9 ESL05948.1 - 0.058 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AIG1 PF04548.11 ESL05948.1 - 0.077 12.0 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Zeta_toxin PF06414.7 ESL05948.1 - 0.14 11.2 0.0 0.75 8.8 0.0 2.1 1 1 0 1 1 1 0 Zeta toxin G-alpha PF00503.15 ESL05948.1 - 0.21 10.2 1.1 1 7.9 0.2 2.0 1 1 1 2 2 2 0 G-protein alpha subunit PHO4 PF01384.15 ESL05950.1 - 7e-106 353.5 25.6 9.1e-106 353.1 17.7 1.1 1 0 0 1 1 1 1 Phosphate transporter family Myco_arth_vir_N PF09610.5 ESL05950.1 - 0.08 12.9 0.4 0.68 9.9 0.0 2.9 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimer_Tnp_hAT PF05699.9 ESL05950.1 - 0.19 11.3 1.3 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Peptidase_C1 PF00112.18 ESL05951.1 - 4.7e-67 226.0 4.2 6.9e-67 225.5 2.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.3 ESL05951.1 - 2.4e-23 81.9 8.4 2.4e-23 81.9 5.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.7 ESL05951.1 - 2.3e-10 40.6 0.0 3.4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 ESL05951.1 - 0.0001 20.9 0.4 0.0023 16.5 0.0 2.0 2 0 0 2 2 2 1 Peptidase C1-like family Ribosomal_S8 PF00410.14 ESL05952.1 - 6.7e-14 51.8 0.0 9.8e-14 51.3 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Metallophos PF00149.23 ESL05953.1 - 2.1e-22 79.5 0.1 3.6e-22 78.7 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF913 PF06025.7 ESL05953.1 - 0.0054 15.5 0.1 0.0086 14.8 0.1 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) EF-hand_7 PF13499.1 ESL05953.1 - 0.0079 16.3 0.1 0.1 12.7 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESL05953.1 - 0.15 12.0 0.1 1.8 8.6 0.0 2.9 4 0 0 4 4 4 0 EF-hand domain Sgf11 PF08209.6 ESL05953.1 - 2.4 7.5 8.5 1.6 8.1 0.0 3.1 2 1 1 3 3 3 0 Sgf11 (transcriptional regulation protein) DM PF00751.13 ESL05953.1 - 8.1 6.0 11.2 0.22 11.0 3.2 1.8 2 0 0 2 2 2 0 DM DNA binding domain IBR PF01485.16 ESL05953.1 - 9.9 6.1 11.5 1.1e+02 2.7 8.0 2.3 1 1 0 1 1 1 0 IBR domain Pkinase PF00069.20 ESL05954.1 - 1e-48 165.7 0.0 1.7e-48 165.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05954.1 - 1.2e-23 83.5 0.0 3.6e-22 78.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05954.1 - 1.1e-06 27.7 0.0 0.0033 16.4 0.0 2.8 3 0 0 3 3 3 2 Kinase-like Seadorna_VP7 PF07387.6 ESL05954.1 - 0.01 14.6 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 ESL05954.1 - 0.025 13.6 0.0 0.032 13.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Galactosyl_T PF01762.16 ESL05955.1 - 5.3e-09 35.9 0.3 0.0011 18.5 0.1 3.4 3 1 0 3 3 3 2 Galactosyltransferase Thioredoxin PF00085.15 ESL05957.1 - 1.3e-36 124.3 0.2 1.1e-17 63.6 0.0 4.2 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.1 ESL05957.1 - 6.5e-24 84.7 0.0 2e-16 60.3 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 ESL05957.1 - 1.2e-10 41.5 0.0 0.00044 20.4 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESL05957.1 - 7.2e-07 29.2 0.0 0.013 15.6 0.0 3.4 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.1 ESL05957.1 - 1.6e-06 28.0 0.1 0.00072 19.5 0.0 3.5 4 0 0 4 4 4 1 Thioredoxin-like AhpC-TSA PF00578.16 ESL05957.1 - 4.5e-06 26.3 0.1 0.0018 17.9 0.0 2.7 2 1 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 ESL05957.1 - 5.6e-06 25.9 0.2 0.0043 16.6 0.0 2.8 2 2 0 2 2 2 2 Redoxin Calsequestrin PF01216.12 ESL05957.1 - 0.00088 18.1 0.0 0.0014 17.4 0.0 1.2 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_4 PF13462.1 ESL05957.1 - 0.0026 17.7 0.0 0.86 9.5 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_9 PF14595.1 ESL05957.1 - 0.013 15.0 0.0 0.034 13.7 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin HyaE PF07449.6 ESL05957.1 - 0.042 13.7 0.0 0.19 11.6 0.0 2.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Pkinase PF00069.20 ESL05960.1 - 1.1e-37 129.6 0.0 1.9e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05960.1 - 1.2e-19 70.3 0.0 2.3e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL05960.1 - 8.7e-06 24.8 0.0 2.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL05960.1 - 0.032 13.9 0.1 0.071 12.8 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family IL4 PF00727.13 ESL05960.1 - 0.049 13.5 0.1 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 Interleukin 4 Seadorna_VP7 PF07387.6 ESL05960.1 - 0.17 10.6 0.1 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 zf-RING_4 PF14570.1 ESL05960.1 - 6.4 6.4 15.1 12 5.5 10.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Cyclin_N PF00134.18 ESL05962.1 - 0.0052 16.3 0.0 0.016 14.7 0.0 1.8 1 1 0 1 1 1 1 Cyclin, N-terminal domain DUF2300 PF10062.4 ESL05964.1 - 0.14 11.8 0.5 0.24 11.1 0.3 1.3 1 0 0 1 1 1 0 Predicted secreted protein (DUF2300) BRCT PF00533.21 ESL05966.1 - 0.0047 17.0 0.0 0.018 15.2 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain tRNA_Me_trans PF03054.11 ESL05967.1 - 4.9e-46 156.9 0.0 2.6e-36 124.9 0.0 3.3 3 0 0 3 3 3 3 tRNA methyl transferase Asn_synthase PF00733.16 ESL05967.1 - 0.00058 19.4 0.0 0.0012 18.3 0.0 1.8 1 1 0 1 1 1 1 Asparagine synthase Pkinase PF00069.20 ESL05968.1 - 2.2e-34 118.8 0.0 2.6e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05968.1 - 3.3e-15 55.8 0.0 3.8e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL05968.1 - 3.2e-06 27.0 0.1 0.00073 19.3 0.0 2.9 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL05968.1 - 0.015 14.4 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL05968.1 - 0.041 12.8 0.0 0.2 10.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESL05968.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Gp_dh_C PF02800.15 ESL05969.1 - 1.5e-63 212.9 0.1 2.1e-63 212.4 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL05969.1 - 1.1e-39 135.7 0.0 2.1e-39 134.9 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain RINGv PF12906.2 ESL05970.1 - 5.8e-12 45.4 10.9 1.1e-11 44.6 7.5 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 ESL05970.1 - 0.021 14.6 5.7 0.041 13.7 3.9 1.5 1 0 0 1 1 1 0 Ring finger domain zf-P11 PF03854.9 ESL05970.1 - 0.12 11.9 0.3 0.34 10.4 0.2 1.8 1 0 0 1 1 1 0 P-11 zinc finger PHD PF00628.24 ESL05970.1 - 0.47 10.1 6.7 1.1 8.9 4.7 1.7 1 1 0 1 1 1 0 PHD-finger FANCL_C PF11793.3 ESL05970.1 - 1.3 8.9 4.9 2.7 8.0 3.4 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.1 ESL05970.1 - 3.1 7.5 5.5 6 6.6 3.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Nucleoside_tran PF01733.13 ESL05971.1 - 2.4e-31 109.0 0.8 4e-31 108.3 0.6 1.3 1 1 0 1 1 1 1 Nucleoside transporter DUF951 PF06107.6 ESL05971.1 - 0.13 11.7 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) Vma12 PF11712.3 ESL05971.1 - 0.59 9.8 5.5 1.3 8.6 0.0 2.5 2 1 1 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Claudin_2 PF13903.1 ESL05971.1 - 9.5 5.8 11.8 2.4 7.8 2.3 2.6 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction MFS_1 PF07690.11 ESL05973.1 - 1.8e-17 63.0 32.4 5.1e-15 55.0 15.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL05973.1 - 5.3e-10 38.9 19.7 5.3e-10 38.9 13.7 2.7 2 2 0 2 2 2 1 Nodulin-like CLN3 PF02487.12 ESL05974.1 - 1.3e-28 99.9 17.5 1e-17 64.0 3.6 3.0 3 0 0 3 3 3 3 CLN3 protein Mito_carr PF00153.22 ESL05975.1 - 5.4e-69 227.9 4.9 1.5e-25 88.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF4257 PF14074.1 ESL05975.1 - 0.00092 18.8 0.0 0.68 9.6 0.1 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF4257) Las1 PF04031.8 ESL05976.1 - 7.2e-37 126.4 0.0 1.3e-36 125.6 0.0 1.4 2 0 0 2 2 2 1 Las1-like Calpain_III PF01067.17 ESL05977.1 - 3.3e-37 127.3 0.0 5.4e-08 32.5 0.0 8.5 7 1 0 7 7 7 6 Calpain large subunit, domain III Peptidase_C2 PF00648.16 ESL05977.1 - 3.1e-30 105.2 0.1 5.3e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease HECT PF00632.20 ESL05978.1 - 2e-12 46.9 0.0 0.0027 16.9 0.0 4.8 4 1 1 5 5 5 4 HECT-domain (ubiquitin-transferase) CpeS PF09367.5 ESL05978.1 - 0.00054 19.8 0.0 0.00094 19.1 0.0 1.3 1 0 0 1 1 1 1 CpeS-like protein FAD_binding_1 PF00667.15 ESL05978.1 - 0.065 12.6 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain DERM PF14704.1 ESL05979.1 - 0.058 13.3 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Dermatopontin Trypsin_2 PF13365.1 ESL05980.1 - 1.8e-06 27.9 0.0 3.4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Atx10homo_assoc PF09759.4 ESL05980.1 - 0.1 12.3 0.1 0.34 10.6 0.0 1.8 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain POX PF07526.6 ESL05981.1 - 0.041 14.1 6.0 0.046 13.9 0.9 2.5 2 1 1 3 3 3 0 Associated with HOX DUF1387 PF07139.6 ESL05981.1 - 0.096 12.2 1.0 0.18 11.4 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Lipase_3 PF01764.20 ESL05982.1 - 1.2e-38 131.9 0.0 1.5e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESL05982.1 - 0.00053 19.4 0.0 0.0023 17.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.2 ESL05982.1 - 0.0049 16.7 0.1 0.0054 16.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2048 PF09752.4 ESL05982.1 - 0.029 13.2 0.0 0.036 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Abhydrolase_5 PF12695.2 ESL05982.1 - 0.031 14.0 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL05982.1 - 0.12 11.8 0.1 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_M20 PF01546.23 ESL05983.1 - 2.4e-26 92.3 0.2 2.9e-26 92.1 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL05983.1 - 5.1e-09 35.8 0.0 1.2e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 ESL05983.1 - 0.0074 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M8 PF01457.11 ESL05984.1 - 3.8e-92 309.3 0.0 4.3e-92 309.1 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESL05984.1 - 0.0036 17.2 0.0 0.007 16.3 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 ESL05984.1 - 0.027 15.0 0.1 0.055 13.9 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 ESL05984.1 - 0.044 13.3 0.1 0.069 12.6 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.3 ESL05984.1 - 0.064 12.5 0.1 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.19 ESL05984.1 - 0.2 11.0 0.5 0.36 10.1 0.3 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) GTP_EFTU PF00009.22 ESL05986.1 - 1.1e-61 207.5 0.2 1.8e-61 206.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESL05986.1 - 9.3e-36 122.0 0.0 2.2e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 ESL05986.1 - 3.3e-21 74.9 0.0 8.2e-21 73.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 ESL05986.1 - 7e-14 51.4 0.1 2.3e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESL05986.1 - 6.3e-13 48.6 0.1 2.1e-12 46.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Pkinase PF00069.20 ESL05987.1 - 6.2e-60 202.5 0.0 1.5e-57 194.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL05987.1 - 1.2e-40 139.1 0.3 8.6e-38 129.8 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.9 ESL05987.1 - 0.00014 21.0 0.4 0.00035 19.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL05987.1 - 0.02 14.6 0.0 0.054 13.2 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family MCM PF00493.18 ESL05988.1 - 1.4e-120 402.0 0.2 2e-120 401.5 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 ESL05988.1 - 7.5e-08 31.7 0.0 2.8e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.1 ESL05988.1 - 3.1e-06 27.6 0.0 9.1e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.9 ESL05988.1 - 0.0009 18.9 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESL05988.1 - 0.0038 16.8 0.0 0.0092 15.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_2 PF13335.1 ESL05988.1 - 0.0044 17.3 1.9 0.2 12.0 0.1 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESL05988.1 - 0.016 14.6 0.1 0.038 13.4 0.1 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF188 PF02639.9 ESL05988.1 - 0.079 12.4 1.2 6 6.3 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 ABC2_membrane PF01061.19 ESL05990.1 - 3.7e-30 104.6 15.5 3.7e-30 104.6 10.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESL05990.1 - 6.6e-20 71.7 0.0 1.1e-19 71.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESL05990.1 - 2.5e-05 24.3 0.4 0.094 12.6 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 ESL05990.1 - 0.00061 19.8 0.2 0.0022 17.9 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 ESL05990.1 - 0.0019 17.4 0.0 0.0094 15.2 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ESL05990.1 - 0.0023 18.7 0.0 0.0066 17.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain DUF258 PF03193.11 ESL05990.1 - 0.0046 16.1 0.0 0.0095 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 ESL05990.1 - 0.0086 16.0 0.0 0.027 14.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.7 ESL05990.1 - 0.0097 15.5 0.3 0.024 14.2 0.0 1.8 2 0 0 2 2 1 1 NACHT domain AAA_29 PF13555.1 ESL05990.1 - 0.011 15.2 0.2 0.034 13.6 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SE PF00437.15 ESL05990.1 - 0.016 14.1 0.0 0.048 12.5 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.1 ESL05990.1 - 0.018 14.7 0.1 0.048 13.4 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 ESL05990.1 - 0.02 15.0 0.0 0.072 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain PDR_assoc PF08370.6 ESL05990.1 - 0.026 14.0 2.9 0.13 11.8 0.0 3.0 3 0 0 3 3 3 0 Plant PDR ABC transporter associated AAA_28 PF13521.1 ESL05990.1 - 0.027 14.4 0.0 0.073 13.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESL05990.1 - 0.038 13.4 0.2 0.075 12.4 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family NTPase_1 PF03266.10 ESL05990.1 - 0.044 13.5 0.0 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.1 ESL05990.1 - 0.094 12.2 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 ESL05990.1 - 0.14 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.12 ESL05990.1 - 0.14 11.9 0.4 0.28 10.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_10 PF12846.2 ESL05990.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain ATP_bind_1 PF03029.12 ESL05990.1 - 0.16 11.4 0.1 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein cobW PF02492.14 ESL05990.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.1 ESL05990.1 - 0.18 12.0 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.4 ESL05990.1 - 0.21 10.1 0.0 0.34 9.4 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class ABC2_membrane_3 PF12698.2 ESL05990.1 - 1.6 7.6 19.3 0.017 14.1 6.0 2.3 2 1 0 2 2 2 0 ABC-2 family transporter protein DUF812 PF05667.6 ESL05991.1 - 0.052 12.0 0.1 0.072 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ETF PF01012.16 ESL05992.1 - 3.7e-37 127.5 0.1 4.7e-37 127.2 0.1 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Atg14 PF10186.4 ESL05993.1 - 0.23 10.3 6.4 0.34 9.8 4.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DHHA2 PF02833.9 ESL05995.1 - 1.8e-19 70.1 0.0 2.9e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 ESL05995.1 - 1.7e-11 43.9 0.0 3.4e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 DHH family UDPG_MGDP_dh_N PF03721.9 ESL05996.1 - 3.8e-49 166.5 0.1 7.2e-49 165.6 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 ESL05996.1 - 5.6e-35 119.6 0.1 3.3e-34 117.2 0.1 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 ESL05996.1 - 5.5e-30 103.4 0.0 1.3e-29 102.2 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Saccharop_dh PF03435.13 ESL05996.1 - 0.049 12.6 0.0 0.074 12.0 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Ldh_1_N PF00056.18 ESL05996.1 - 0.11 12.3 0.1 1.4 8.7 0.0 2.5 3 0 0 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain DUF3439 PF11921.3 ESL05997.1 - 0.27 10.9 7.8 0.052 13.2 1.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Robl_LC7 PF03259.12 ESL06000.1 - 0.095 12.2 0.0 0.17 11.5 0.0 1.6 1 1 0 1 1 1 0 Roadblock/LC7 domain Abhydrolase_6 PF12697.2 ESL06001.1 - 6e-27 94.9 0.1 7.6e-27 94.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL06001.1 - 1.2e-08 34.7 0.1 4.3e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.8 ESL06001.1 - 2.7e-06 27.1 0.0 3.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.15 ESL06001.1 - 6.3e-06 25.9 0.2 2.7e-05 23.8 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 ESL06001.1 - 0.00052 19.6 0.0 0.0009 18.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Peptidase_S9 PF00326.16 ESL06001.1 - 0.00082 18.6 0.0 0.002 17.3 0.0 1.5 1 1 1 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 ESL06001.1 - 0.0019 17.1 0.0 0.0031 16.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_9 PF10081.4 ESL06001.1 - 0.014 14.1 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Thioesterase PF00975.15 ESL06001.1 - 0.015 15.5 0.1 2.8 8.1 0.0 2.5 1 1 1 2 2 2 0 Thioesterase domain DUF2974 PF11187.3 ESL06001.1 - 0.027 13.8 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Esterase PF00756.15 ESL06001.1 - 0.028 13.8 0.0 0.059 12.7 0.0 1.4 1 0 0 1 1 1 0 Putative esterase PAF-AH_p_II PF03403.8 ESL06001.1 - 0.053 11.8 0.0 0.077 11.2 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Cutinase PF01083.17 ESL06001.1 - 0.073 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Cutinase DUF676 PF05057.9 ESL06001.1 - 0.13 11.5 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF3989 PF13150.1 ESL06002.1 - 0.01 15.2 0.1 0.017 14.5 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) DUF1211 PF06736.6 ESL06002.1 - 0.03 14.4 0.3 0.039 14.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) AA_permease PF00324.16 ESL06002.1 - 0.052 11.8 0.1 0.064 11.5 0.1 1.0 1 0 0 1 1 1 0 Amino acid permease Utp13 PF08625.6 ESL06003.1 - 0.097 12.3 2.0 0.15 11.6 0.1 2.2 3 0 0 3 3 3 0 Utp13 specific WD40 associated domain R3H PF01424.17 ESL06005.1 - 3.1e-10 39.5 0.0 8.6e-10 38.1 0.0 1.8 1 0 0 1 1 1 1 R3H domain UPF0547 PF10571.4 ESL06006.1 - 5.3e-07 29.2 0.1 3e-05 23.6 0.0 3.3 3 1 0 3 3 3 1 Uncharacterised protein family UPF0547 DnaJ PF00226.26 ESL06006.1 - 5.2e-06 26.1 0.0 1.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain zinc_ribbon_2 PF13240.1 ESL06006.1 - 2.7 7.5 8.9 5 6.7 0.0 3.7 3 1 0 3 3 3 0 zinc-ribbon domain Rad50_zn_hook PF04423.9 ESL06006.1 - 5.9 6.4 7.5 1.2 8.6 0.3 2.8 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RING_3 PF14369.1 ESL06006.1 - 6.5 6.8 12.2 6.7 6.7 0.2 3.8 3 1 1 4 4 4 0 zinc-finger zinc_ribbon_5 PF13719.1 ESL06006.1 - 7.1 6.2 18.4 6.2 6.5 0.1 4.9 5 0 0 5 5 5 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 ESL06006.1 - 9.7 5.9 17.8 13 5.5 0.1 5.0 5 0 0 5 5 5 0 zinc-ribbon domain adh_short PF00106.20 ESL06007.1 - 4.2e-27 95.0 3.9 7.4e-27 94.3 2.7 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESL06007.1 - 9.2e-18 64.8 0.0 1.1e-17 64.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESL06007.1 - 2.6e-17 63.0 2.5 1e-16 61.1 1.8 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 ESL06007.1 - 1.3e-08 34.5 0.1 4.1e-08 32.9 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESL06007.1 - 0.0021 18.0 0.1 0.0041 17.1 0.1 1.5 2 1 0 2 2 2 1 NADH(P)-binding RmlD_sub_bind PF04321.12 ESL06007.1 - 0.017 14.0 0.1 0.024 13.5 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NAD_binding_4 PF07993.7 ESL06007.1 - 0.04 12.8 0.0 3.2 6.6 0.0 2.4 1 1 1 3 3 3 0 Male sterility protein 2-Hacid_dh_C PF02826.14 ESL06008.1 - 9.2e-46 155.2 0.0 1.1e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESL06008.1 - 2.7e-06 26.8 0.0 3.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_10 PF13460.1 ESL06008.1 - 9.5e-06 25.7 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 ESL06008.1 - 0.00011 22.1 0.1 0.00025 21.0 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESL06008.1 - 0.0002 21.2 0.0 0.00026 20.8 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESL06008.1 - 0.00021 21.6 0.0 0.00039 20.8 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 ESL06008.1 - 0.0011 18.7 0.1 0.003 17.4 0.1 1.7 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.14 ESL06008.1 - 0.003 16.2 0.0 0.0036 15.9 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.16 ESL06008.1 - 0.0059 16.2 0.1 0.013 15.1 0.0 1.4 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.1 ESL06008.1 - 0.01 16.0 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Gp_dh_N PF00044.19 ESL06008.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESL06008.1 - 0.034 13.8 0.4 0.056 13.0 0.3 1.4 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 ESL06008.1 - 0.034 13.1 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase XdhC_C PF13478.1 ESL06008.1 - 0.059 13.6 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain DUF2360 PF10152.4 ESL06009.1 - 0.073 13.3 0.1 0.089 13.0 0.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Thioredoxin PF00085.15 ESL06010.1 - 3.2e-20 71.7 0.0 3.5e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL06010.1 - 0.00012 22.2 0.1 0.0011 19.1 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Phosducin PF02114.11 ESL06010.1 - 0.00028 19.6 0.0 0.00033 19.4 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin_8 PF13905.1 ESL06010.1 - 0.015 15.4 0.3 1.1 9.3 0.1 2.1 1 1 1 2 2 2 0 Thioredoxin-like HyaE PF07449.6 ESL06010.1 - 0.044 13.6 0.0 0.065 13.1 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.16 ESL06010.1 - 0.05 13.2 0.1 0.11 12.2 0.1 1.5 1 1 0 1 1 1 0 AhpC/TSA family Glutaredoxin PF00462.19 ESL06010.1 - 0.066 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin TMEM164 PF14808.1 ESL06011.1 - 3.6e-10 39.4 11.2 4.5e-10 39.1 7.7 1.1 1 0 0 1 1 1 1 TMEM164 family DUF2973 PF11189.3 ESL06011.1 - 0.32 10.8 0.1 0.32 10.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) Pkinase PF00069.20 ESL06012.1 - 1.7e-50 171.6 0.0 3.2e-50 170.6 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06012.1 - 2e-28 99.2 0.0 3e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_1 PF00560.28 ESL06012.1 - 1.7e-09 36.4 2.0 0.58 10.4 0.0 6.3 6 0 0 6 6 5 2 Leucine Rich Repeat LRR_4 PF12799.2 ESL06012.1 - 3.7e-09 35.9 0.2 0.0025 17.3 0.2 3.7 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL06012.1 - 4.4e-06 26.3 0.7 0.0038 16.9 0.1 3.2 1 1 1 3 3 3 2 Leucine rich repeat APH PF01636.18 ESL06012.1 - 0.038 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL06012.1 - 0.039 12.9 0.0 0.063 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like zf-B_box PF00643.19 ESL06012.1 - 0.063 13.1 37.6 0.13 12.1 8.1 4.1 4 0 0 4 4 4 0 B-box zinc finger LRR_6 PF13516.1 ESL06012.1 - 0.074 13.1 2.2 3.9 7.8 0.0 3.8 3 1 1 4 4 4 0 Leucine Rich repeat Ribosomal_L27 PF01016.14 ESL06012.1 - 0.088 12.6 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Ribosomal L27 protein LRR_7 PF13504.1 ESL06012.1 - 0.14 12.4 2.9 13 6.5 0.0 4.8 6 0 0 6 6 4 0 Leucine rich repeat TPR_11 PF13414.1 ESL06013.1 - 2.4e-95 312.2 44.5 2.4e-17 62.3 0.8 9.0 5 2 3 9 9 9 9 TPR repeat TPR_1 PF00515.23 ESL06013.1 - 1.8e-84 274.1 36.7 1.5e-08 33.9 0.0 14.8 14 1 0 14 14 14 13 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06013.1 - 3.9e-69 223.0 37.6 9.4e-08 31.4 0.0 14.9 15 0 0 15 15 14 13 Tetratricopeptide repeat TPR_17 PF13431.1 ESL06013.1 - 4e-51 167.0 26.4 3.7e-05 23.5 0.0 13.0 13 0 0 13 13 13 10 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06013.1 - 6.9e-45 150.8 33.5 4.8e-06 27.0 0.2 9.8 7 3 3 10 10 9 9 Tetratricopeptide repeat TPR_9 PF13371.1 ESL06013.1 - 1.3e-35 121.1 20.5 5.4e-05 22.9 0.0 11.3 4 3 7 11 11 11 9 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06013.1 - 5.2e-35 119.2 40.3 1.1e-07 31.6 0.1 9.7 3 2 7 10 10 9 8 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06013.1 - 1.3e-29 99.7 28.6 0.013 15.2 0.4 14.0 12 2 2 14 14 14 7 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06013.1 - 3.2e-24 85.0 13.3 0.00059 20.1 0.1 9.2 7 2 2 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06013.1 - 1.2e-22 78.3 20.6 0.08 13.6 0.0 13.3 6 4 8 14 14 14 6 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06013.1 - 3.4e-21 74.1 21.8 0.047 14.1 0.0 12.1 14 0 0 14 14 11 5 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06013.1 - 4.6e-21 72.8 22.5 0.22 11.3 0.1 13.7 13 1 1 14 14 14 4 Tetratricopeptide repeat Apc3 PF12895.2 ESL06013.1 - 2e-15 56.6 19.2 0.0015 18.6 0.5 6.9 4 2 3 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.4 ESL06013.1 - 7e-13 47.5 13.3 0.24 10.6 0.0 10.0 10 0 0 10 10 10 3 SHNi-TPR NARP1 PF12569.3 ESL06013.1 - 2e-07 30.1 14.9 0.0042 15.9 0.1 6.3 3 2 3 7 7 7 3 NMDA receptor-regulated protein 1 TPR_15 PF13429.1 ESL06013.1 - 4.1e-07 29.3 7.9 0.037 13.1 0.1 7.6 3 2 1 7 7 7 1 Tetratricopeptide repeat TPR_5 PF12688.2 ESL06013.1 - 2.4e-06 27.5 15.1 0.018 15.1 0.2 6.7 6 2 0 6 6 6 1 Tetratrico peptide repeat BTAD PF03704.12 ESL06013.1 - 0.00011 22.4 15.3 2.3 8.5 0.6 6.4 2 2 2 6 6 6 1 Bacterial transcriptional activator domain MIT PF04212.13 ESL06013.1 - 0.0014 18.4 24.4 7.8 6.4 0.0 9.8 8 2 0 9 9 9 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.4 ESL06013.1 - 0.002 17.5 3.8 1.3 8.3 0.0 4.9 4 2 0 5 5 5 1 26S proteasome subunit RPN7 TPR_20 PF14561.1 ESL06013.1 - 0.0073 16.4 14.4 0.055 13.5 0.1 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL06013.1 - 0.014 15.2 9.0 6.7 6.6 0.0 5.7 6 1 0 6 6 4 0 Fis1 C-terminal tetratricopeptide repeat NYD-SP12_N PF15015.1 ESL06013.1 - 0.02 13.1 0.0 0.039 12.2 0.0 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal FAT PF02259.18 ESL06013.1 - 0.022 13.7 0.3 0.17 10.8 0.0 2.6 2 1 0 2 2 2 0 FAT domain TPR_4 PF07721.9 ESL06013.1 - 0.36 11.3 18.5 4.9 7.8 0.4 8.0 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL06013.1 - 6.4 6.8 26.3 10 6.2 0.0 8.8 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06014.1 - 9e-17 60.4 30.3 5.2e-11 42.0 0.6 6.4 6 1 0 6 6 6 4 TPR repeat TPR_12 PF13424.1 ESL06014.1 - 8.8e-10 38.3 34.1 0.00018 21.4 0.6 7.5 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06014.1 - 1.3e-07 30.9 8.7 0.0016 18.0 0.2 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06014.1 - 4.3e-07 30.4 45.2 3.6e-05 24.3 0.3 7.4 5 3 1 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06014.1 - 0.00034 20.2 41.1 0.0009 18.9 0.6 8.3 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06014.1 - 0.0051 16.3 1.0 0.0051 16.3 0.7 7.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL06014.1 - 0.0067 16.2 0.0 0.0067 16.2 0.0 4.9 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06014.1 - 0.025 14.9 1.2 0.025 14.9 0.8 5.4 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06014.1 - 0.4 11.4 36.3 0.3 11.8 0.1 8.0 7 2 2 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06014.1 - 3.5 7.6 15.4 11 6.1 0.1 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Glutaredoxin PF00462.19 ESL06016.1 - 7.4e-20 70.7 1.4 2.6e-14 52.9 0.0 3.0 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.15 ESL06016.1 - 5.7e-16 58.0 0.1 1e-15 57.2 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESL06016.1 - 3.5e-05 23.8 0.5 0.00036 20.5 0.1 2.4 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.1 ESL06016.1 - 4.7e-05 23.3 0.1 9.6e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 ESL06016.1 - 0.0061 16.7 0.7 0.026 14.7 0.5 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain GST_N_3 PF13417.1 ESL06016.1 - 0.065 13.4 0.0 0.85 9.8 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Redoxin PF08534.5 ESL06016.1 - 0.073 12.6 0.0 0.29 10.6 0.0 1.9 2 0 0 2 2 2 0 Redoxin AhpC-TSA PF00578.16 ESL06016.1 - 0.083 12.5 0.2 0.27 10.9 0.1 1.9 1 1 2 3 3 3 0 AhpC/TSA family Glyco_hydro_53 PF07745.8 ESL06016.1 - 0.14 10.9 0.1 0.68 8.6 0.0 2.0 1 1 2 3 3 3 0 Glycosyl hydrolase family 53 Flagellin_N PF00669.15 ESL06017.1 - 0.024 14.4 3.2 0.05 13.4 1.7 2.1 1 1 0 1 1 1 0 Bacterial flagellin N-terminal helical region Vps52 PF04129.7 ESL06017.1 - 0.16 10.5 0.3 0.21 10.0 0.2 1.2 1 0 0 1 1 1 0 Vps52 / Sac2 family DUF972 PF06156.8 ESL06017.1 - 0.17 12.2 1.8 0.38 11.1 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CALCOCO1 PF07888.6 ESL06017.1 - 0.4 8.9 4.2 0.53 8.5 2.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like NUDIX PF00293.23 ESL06018.1 - 2.6e-14 52.9 0.0 4.7e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Aa_trans PF01490.13 ESL06020.1 - 4.8e-29 101.0 11.9 5.3e-29 100.9 8.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein WD40 PF00400.27 ESL06021.1 - 3.1e-21 74.3 9.0 4e-07 29.6 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Utp21 PF04192.7 ESL06021.1 - 7.2e-21 74.3 0.0 1.1e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain PQQ_2 PF13360.1 ESL06021.1 - 2e-06 27.4 0.0 0.00013 21.5 0.0 2.8 2 1 0 2 2 2 1 PQQ-like domain Nup160 PF11715.3 ESL06021.1 - 0.018 13.1 0.2 3 5.8 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Peptidase_C50 PF03568.12 ESL06022.1 - 6.1e-34 117.3 0.0 3.2e-28 98.5 0.0 2.1 2 0 0 2 2 2 2 Peptidase family C50 CHAT PF12770.2 ESL06022.1 - 1e-05 24.8 0.0 0.00027 20.1 0.0 2.5 2 0 0 2 2 2 1 CHAT domain Ank_2 PF12796.2 ESL06023.1 - 2.4e-51 172.0 12.7 5.3e-16 58.7 0.1 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 ESL06023.1 - 4.1e-42 139.9 4.7 6.4e-09 35.1 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 ESL06023.1 - 2.3e-36 123.5 1.5 9.5e-08 32.3 0.0 4.9 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL06023.1 - 2.3e-33 113.4 4.2 1.5e-09 37.7 0.0 4.9 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL06023.1 - 2.2e-29 98.5 3.8 0.0015 18.6 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat TPR_11 PF13414.1 ESL06023.1 - 8.4e-16 57.3 1.7 4.8e-09 35.7 1.1 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESL06023.1 - 7.8e-08 31.6 1.8 1.9e-05 24.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06023.1 - 5.2e-06 25.9 5.1 0.0011 18.7 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL06023.1 - 0.0016 18.5 0.5 10 6.6 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06023.1 - 0.0052 17.3 0.0 0.064 13.9 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06023.1 - 0.013 15.2 0.5 7.6 6.6 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06023.1 - 0.032 14.9 0.3 1.1 10.0 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL06023.1 - 0.046 13.8 0.3 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESL06023.1 - 0.048 13.5 0.9 0.15 11.9 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06023.1 - 0.11 12.9 1.3 0.42 10.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06024.1 - 4.4e-06 26.5 3.7 3.9e-05 23.4 0.6 3.2 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06024.1 - 0.019 15.5 2.9 43 5.1 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06024.1 - 0.036 13.6 0.7 1.1 8.9 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06024.1 - 0.037 13.6 1.9 1.9 8.1 0.2 2.8 1 1 1 2 2 2 0 TPR repeat TPR_2 PF07719.12 ESL06024.1 - 0.042 13.7 8.0 0.14 12.1 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06024.1 - 0.13 12.7 2.0 1.7 9.3 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06024.1 - 0.18 11.6 1.2 1.6 8.6 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TFIIA PF03153.8 ESL06025.1 - 1.2 8.9 14.3 1.9 8.2 9.6 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IncA PF04156.9 ESL06025.1 - 6.3 6.3 10.4 12 5.3 7.2 1.4 1 0 0 1 1 1 0 IncA protein LRR_4 PF12799.2 ESL06027.1 - 3.3e-17 61.6 11.5 2.1e-07 30.4 1.6 4.4 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESL06027.1 - 2e-07 30.7 1.2 2.9e-05 23.7 0.2 3.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.1 ESL06027.1 - 8.2e-07 28.6 12.2 0.0029 17.3 1.9 3.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 ESL06027.1 - 0.00038 20.1 10.2 0.79 10.1 0.0 5.6 6 0 0 6 6 6 2 Leucine rich repeat LRR_6 PF13516.1 ESL06027.1 - 0.00048 19.9 13.9 0.3 11.2 0.3 4.8 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.28 ESL06027.1 - 0.0024 17.6 16.0 1.2 9.4 0.1 5.9 5 1 1 6 6 6 2 Leucine Rich Repeat DnaJ PF00226.26 ESL06028.1 - 1.1e-13 50.6 0.0 2.4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain TraG-D_C PF12696.2 ESL06028.1 - 0.047 13.5 2.1 0.54 10.1 0.0 2.8 2 1 1 3 3 3 0 TraM recognition site of TraD and TraG SOG2 PF10428.4 ESL06028.1 - 0.072 11.7 2.2 0.094 11.3 1.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Dynein_light PF01221.13 ESL06029.1 - 4.4e-27 93.9 1.4 5.3e-27 93.6 1.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 YtxH PF12732.2 ESL06029.1 - 0.054 13.8 0.0 0.07 13.5 0.0 1.2 1 0 0 1 1 1 0 YtxH-like protein TruD PF01142.13 ESL06030.1 - 0.0012 17.5 0.0 0.0022 16.7 0.0 1.3 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) Vault PF01505.13 ESL06031.1 - 2.5e-59 197.0 6.9 7.8e-14 51.4 0.0 6.6 6 0 0 6 6 6 5 Major Vault Protein repeat MVP_shoulder PF11978.3 ESL06031.1 - 1.1e-51 173.6 0.1 4.5e-51 171.6 0.1 2.2 2 0 0 2 2 2 1 Shoulder domain DUF3601 PF12208.3 ESL06031.1 - 0.00079 19.3 0.0 2.5 8.0 0.0 4.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3601) His_Phos_2 PF00328.17 ESL06034.1 - 3.4e-06 26.6 0.1 0.00012 21.5 0.1 2.7 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) MORN PF02493.15 ESL06035.1 - 7.3e-08 31.6 9.3 0.0013 18.3 0.1 3.3 3 0 0 3 3 3 2 MORN repeat CbiZ PF01955.13 ESL06035.1 - 0.046 13.4 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Adenosylcobinamide amidohydrolase Peptidase_M20 PF01546.23 ESL06036.1 - 2.7e-35 121.5 0.1 3.8e-35 121.1 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL06036.1 - 3.9e-18 65.2 0.0 8.1e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.9 ESL06036.1 - 0.049 12.3 0.1 1.1 7.8 0.0 2.3 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase zf-PHD-like PF15446.1 ESL06036.1 - 0.076 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain DBINO PF13892.1 ESL06038.1 - 0.079 13.0 0.1 0.096 12.7 0.0 1.1 1 0 0 1 1 1 0 DNA-binding domain Acyl-CoA_dh_N PF02771.11 ESL06039.1 - 6.7e-09 36.3 0.0 2.2e-08 34.6 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESL06039.1 - 9.1e-09 34.7 0.1 1.9e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain PPR_2 PF13041.1 ESL06040.1 - 6.7e-08 32.3 0.1 0.034 14.1 0.0 4.1 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.15 ESL06040.1 - 1e-07 31.4 0.5 0.00019 21.1 0.1 5.5 7 0 0 7 7 7 1 PPR repeat PPR_3 PF13812.1 ESL06040.1 - 0.0011 19.0 0.1 11 6.5 0.0 5.5 5 0 0 5 5 5 1 Pentatricopeptide repeat domain DUF928 PF06051.7 ESL06040.1 - 0.015 14.9 0.1 0.97 8.9 0.0 2.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF928) UCH PF00443.24 ESL06041.1 - 1.7e-46 158.5 0.0 2.5e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL06041.1 - 1.6e-11 44.2 0.0 4e-11 42.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 ESL06041.1 - 2.7e-06 26.6 0.2 9.4e-06 24.9 0.1 1.9 2 1 0 2 2 2 1 Ubiquitin family YukD PF08817.5 ESL06041.1 - 0.00073 20.0 0.0 0.0018 18.8 0.0 1.7 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.1 ESL06041.1 - 0.052 13.8 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain Peptidase_C28 PF05408.6 ESL06041.1 - 0.11 11.9 0.0 5.6 6.3 0.0 2.3 2 0 0 2 2 2 0 Foot-and-mouth virus L-proteinase DnaJ PF00226.26 ESL06042.1 - 3.4e-08 33.1 0.0 6.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Lar_restr_allev PF14354.1 ESL06042.1 - 0.26 11.5 3.6 0.75 10.1 2.5 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar zinc_ribbon_4 PF13717.1 ESL06042.1 - 0.43 10.3 3.9 1.8 8.3 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESL06042.1 - 1 9.0 4.9 2.3 7.8 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_3 PF14369.1 ESL06042.1 - 1.5 8.9 8.9 1.5 8.8 0.7 2.6 1 1 1 2 2 2 0 zinc-finger Chromo PF00385.19 ESL06043.1 - 0.0017 18.0 0.0 0.0034 17.0 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Oxidored_q6 PF01058.17 ESL06044.1 - 3.4e-19 68.7 0.1 4.6e-19 68.3 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit ADIP PF11559.3 ESL06045.1 - 7.8 6.3 53.0 0.058 13.3 2.3 5.5 4 2 1 6 6 6 0 Afadin- and alpha -actinin-Binding Aa_trans PF01490.13 ESL06046.1 - 3.6e-58 196.9 35.8 4.3e-58 196.7 24.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL06046.1 - 2.4e-08 33.2 11.0 2.4e-08 33.2 7.6 2.7 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family AAA PF00004.24 ESL06047.1 - 5.1e-36 123.7 0.0 8e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESL06047.1 - 3.7e-06 26.7 0.0 8.3e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.7 ESL06047.1 - 8.1e-06 25.0 0.0 1.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESL06047.1 - 1.4e-05 25.2 0.1 0.00024 21.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL06047.1 - 0.00077 18.2 0.0 0.0013 17.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESL06047.1 - 0.0012 18.3 0.0 0.0023 17.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 ESL06047.1 - 0.0024 17.5 0.1 0.0069 16.1 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 ESL06047.1 - 0.0024 18.6 0.0 0.0061 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL06047.1 - 0.0031 17.7 0.0 0.012 15.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 ESL06047.1 - 0.0049 16.2 0.3 0.25 10.7 0.2 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 ESL06047.1 - 0.0057 16.6 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 ESL06047.1 - 0.0066 16.3 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL06047.1 - 0.0086 15.8 0.1 0.019 14.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESL06047.1 - 0.012 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 ESL06047.1 - 0.017 14.7 0.1 0.043 13.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL06047.1 - 0.025 14.7 0.0 0.056 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 ESL06047.1 - 0.036 13.9 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESL06047.1 - 0.048 13.6 0.1 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.9 ESL06047.1 - 0.05 13.5 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) KaiC PF06745.8 ESL06047.1 - 0.054 12.6 0.1 1.1 8.3 0.0 2.2 1 1 1 2 2 2 0 KaiC PhoH PF02562.11 ESL06047.1 - 0.056 12.6 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein LisH PF08513.6 ESL06047.1 - 0.081 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 LisH Sigma54_activat PF00158.21 ESL06047.1 - 0.1 12.0 0.0 1.6 8.1 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain zf-DHHC PF01529.15 ESL06048.1 - 6.5e-31 107.0 12.0 6.5e-31 107.0 8.3 2.1 1 1 0 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.1 ESL06048.1 - 0.1 12.4 2.8 0.23 11.2 1.9 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily FYVE PF01363.16 ESL06048.1 - 0.1 12.4 8.0 0.24 11.3 5.6 1.6 1 0 0 1 1 1 0 FYVE zinc finger HemY_N PF07219.8 ESL06048.1 - 0.13 11.8 1.4 0.32 10.5 0.0 2.2 1 1 1 2 2 2 0 HemY protein N-terminus PPI_Ypi1 PF07491.6 ESL06049.1 - 3.6e-17 61.7 1.1 6.4e-17 60.9 0.7 1.6 1 1 0 1 1 1 1 Protein phosphatase inhibitor Lipoprotein_21 PF14041.1 ESL06049.1 - 0.047 13.6 0.1 0.091 12.7 0.1 1.5 1 1 0 1 1 1 0 LppP/LprE lipoprotein Peptidase_M8 PF01457.11 ESL06050.1 - 6.8e-35 120.4 1.5 7.3e-35 120.2 1.0 1.0 1 0 0 1 1 1 1 Leishmanolysin YopX PF09643.5 ESL06051.1 - 0.05 13.5 0.1 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 YopX protein SET PF00856.23 ESL06052.1 - 1.8e-08 34.8 0.0 8.7e-05 22.8 0.0 4.1 3 1 1 4 4 4 2 SET domain WD40 PF00400.27 ESL06053.1 - 1.8e-11 43.4 8.9 5e-06 26.1 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat EF-hand_7 PF13499.1 ESL06054.1 - 0.00014 21.8 0.0 0.00036 20.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 ESL06054.1 - 0.061 13.2 0.1 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.27 ESL06054.1 - 0.16 11.3 0.1 0.51 9.7 0.1 1.8 1 1 0 1 1 1 0 EF hand Metallophos PF00149.23 ESL06055.1 - 5.7e-08 32.3 0.1 9.2e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL06055.1 - 0.0029 17.4 0.0 0.0038 17.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LMBR1 PF04791.11 ESL06057.1 - 1.1e-36 126.4 28.8 1.1e-21 76.9 6.9 2.1 2 0 0 2 2 2 2 LMBR1-like membrane protein Lig_chan PF00060.21 ESL06057.1 - 0.22 11.2 1.9 0.8 9.4 0.1 2.8 2 0 0 2 2 2 0 Ligand-gated ion channel DHC_N2 PF08393.8 ESL06059.1 - 4e-83 279.2 0.0 1.3e-82 277.5 0.0 1.9 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESL06059.1 - 1.1e-23 83.9 0.0 2e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 DUF1932 PF09130.6 ESL06059.1 - 0.0052 16.5 0.3 0.042 13.5 0.2 2.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) Apolipoprotein PF01442.13 ESL06059.1 - 0.011 15.2 10.4 0.096 12.1 5.5 3.8 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain AAA_17 PF13207.1 ESL06059.1 - 0.016 16.0 0.1 0.22 12.3 0.0 3.1 2 0 0 2 2 2 0 AAA domain YlqD PF11068.3 ESL06059.1 - 0.017 15.1 4.7 0.072 13.1 3.3 2.1 1 0 0 1 1 1 0 YlqD protein AAA PF00004.24 ESL06059.1 - 0.018 15.2 0.0 0.075 13.2 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL06059.1 - 0.078 13.1 0.3 3.2 7.8 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESL06059.1 - 0.11 12.5 0.0 0.11 12.5 0.0 4.3 4 0 0 4 4 4 0 AAA ATPase domain CRA_rpt PF07046.6 ESL06062.1 - 0.18 11.8 2.7 0.34 10.9 1.9 1.4 1 0 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat DUF3024 PF11225.3 ESL06063.1 - 0.31 10.9 2.3 25 4.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3024) DSPc PF00782.15 ESL06064.1 - 8.6e-20 70.6 0.2 1.2e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL06064.1 - 0.00022 20.6 0.3 0.00046 19.5 0.2 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESL06064.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate PEP-utilizers_C PF02896.13 ESL06065.1 - 2.5e-99 331.8 0.0 4e-99 331.2 0.0 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.14 ESL06065.1 - 7.8e-62 209.2 0.0 1.6e-61 208.1 0.0 1.5 1 0 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.18 ESL06065.1 - 2.8e-22 78.0 0.1 6.7e-22 76.8 0.0 1.6 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain Sigma70_r4 PF04545.11 ESL06065.1 - 0.069 12.4 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_24 PF13412.1 ESL06065.1 - 0.16 11.3 0.0 0.39 10.1 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Planc_extracel PF07595.7 ESL06067.1 - 0.011 15.3 1.1 0.011 15.3 0.8 3.0 2 0 0 2 2 2 0 Planctomycete extracellular ENTH PF01417.15 ESL06068.1 - 8.2e-27 93.5 0.0 1.4e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 ENTH domain DUF572 PF04502.8 ESL06068.1 - 0.049 12.8 4.5 0.069 12.3 3.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) CCDC50_N PF15295.1 ESL06068.1 - 0.12 12.2 10.7 1.3 8.9 7.4 2.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Peptidase_C2 PF00648.16 ESL06069.1 - 5.4e-43 147.0 0.0 8e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESL06069.1 - 7.2e-24 83.7 0.0 1.6e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) WPP PF13943.1 ESL06069.1 - 0.063 13.4 0.4 0.17 12.0 0.3 1.7 1 0 0 1 1 1 0 WPP domain Dimerisation PF08100.6 ESL06069.1 - 0.17 11.7 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Dimerisation domain BNR_3 PF13859.1 ESL06070.1 - 0.016 14.2 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 BNR repeat-like domain DUF1993 PF09351.5 ESL06071.1 - 0.0081 16.0 1.7 0.014 15.3 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) Syntaxin PF00804.20 ESL06071.1 - 0.016 15.3 3.9 0.016 15.3 2.7 2.1 2 1 0 2 2 2 0 Syntaxin Flu_NS2 PF00601.14 ESL06071.1 - 0.044 13.9 0.2 0.091 12.9 0.1 1.6 1 1 0 1 1 1 0 Influenza non-structural protein (NS2) DUF3450 PF11932.3 ESL06071.1 - 0.42 9.8 11.4 0.13 11.5 4.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.14 ESL06071.1 - 2.1 6.0 4.2 2.9 5.6 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FUSC PF04632.7 ESL06071.1 - 3.9 5.7 8.4 6.1 5.1 5.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family IncA PF04156.9 ESL06071.1 - 9.9 5.7 18.8 4.3 6.8 8.8 2.6 2 1 1 3 3 3 0 IncA protein C_GCAxxG_C_C PF09719.5 ESL06072.1 - 0.061 13.1 0.1 0.099 12.4 0.1 1.4 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) Peptidase_C70 PF12385.3 ESL06072.1 - 0.12 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 Gly-zipper_OmpA PF13436.1 ESL06072.1 - 3.8 7.2 7.0 8.4 6.0 4.5 1.8 1 1 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Rick_17kDa_Anti PF05433.10 ESL06072.1 - 5 6.8 13.7 13 5.5 9.5 1.7 1 0 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.1 ESL06072.1 - 7.7 6.1 12.4 24 4.5 8.6 1.9 1 1 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.1 ESL06072.1 - 8.5 6.1 12.7 34 4.1 8.8 2.0 1 1 0 1 1 1 0 Glycine zipper Ank PF00023.25 ESL06073.1 - 0.0076 16.0 0.1 0.017 14.9 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.1 ESL06073.1 - 0.0078 16.4 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESL06073.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) WD40 PF00400.27 ESL06074.1 - 1.5e-12 46.8 0.2 0.00017 21.3 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.3 ESL06074.1 - 0.039 12.1 0.1 0.063 11.4 0.1 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESL06074.1 - 0.1 11.3 0.0 0.21 10.2 0.0 1.7 1 0 0 1 1 1 0 Nup133 N terminal like AMP-binding PF00501.23 ESL06075.1 - 1.1e-19 70.1 0.0 4.9e-10 38.3 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme Ribosomal_L4 PF00573.17 ESL06076.1 - 2.5e-39 134.6 0.1 3.7e-39 134.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 ESL06076.1 - 2.2e-14 53.1 6.1 2.6e-14 52.8 3.1 2.0 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Grp1_Fun34_YaaH PF01184.14 ESL06077.1 - 9.5e-40 136.1 8.0 1.2e-39 135.7 5.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3693 PF12472.3 ESL06077.1 - 3.3 7.3 6.2 7.2 6.2 0.1 3.2 3 0 0 3 3 3 0 Phage related protein Aminotran_1_2 PF00155.16 ESL06078.1 - 9.6e-48 162.9 0.0 1.3e-47 162.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 ESL06078.1 - 0.0027 16.8 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 ESL06078.1 - 0.005 16.0 0.0 0.0077 15.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 ESL06078.1 - 0.025 13.3 0.0 0.08 11.6 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V FixQ PF05545.6 ESL06078.1 - 0.066 12.8 1.0 0.15 11.7 0.7 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ TGT PF01702.13 ESL06079.1 - 4.6e-33 114.4 0.3 2.1e-32 112.2 0.2 1.8 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase Aminotran_1_2 PF00155.16 ESL06081.1 - 6.1e-35 120.8 0.0 6.8e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SHMT PF00464.14 ESL06081.1 - 9.6e-06 24.2 0.0 4.8e-05 21.8 0.0 1.8 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 ESL06081.1 - 0.018 13.7 0.1 0.12 11.1 0.0 1.9 2 0 0 2 2 2 0 Aminotransferase class-V DENN PF02141.16 ESL06082.1 - 4.2e-12 46.1 0.2 7.6e-12 45.3 0.1 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain AMP-binding PF00501.23 ESL06084.1 - 5.6e-56 189.7 0.5 8.5e-56 189.1 0.3 1.2 1 0 0 1 1 1 1 AMP-binding enzyme FeoA PF04023.9 ESL06084.1 - 0.088 12.7 0.2 0.63 10.0 0.0 2.4 2 0 0 2 2 2 0 FeoA domain Cyclin PF08613.6 ESL06086.1 - 6.1e-20 72.1 0.3 6.1e-20 72.1 0.2 1.3 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 ESL06086.1 - 2.9e-09 36.5 0.1 4.9e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF1052 PF06319.7 ESL06086.1 - 0.025 13.8 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1052) E1-E2_ATPase PF00122.15 ESL06087.1 - 1e-63 214.4 1.2 1e-63 214.4 0.8 1.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 ESL06087.1 - 1.3e-18 66.2 0.2 1.4e-17 62.9 0.0 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.21 ESL06087.1 - 0.00087 19.7 0.0 0.0019 18.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL06087.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Polysacc_synt_C PF14667.1 ESL06087.1 - 2 8.1 7.0 3.1 7.6 1.2 2.3 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Complex1_LYR_2 PF13233.1 ESL06089.1 - 5.6e-14 52.4 0.0 1.1e-13 51.4 0.0 1.6 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 ESL06089.1 - 0.067 12.9 0.6 0.2 11.4 0.4 1.8 1 1 0 1 1 1 0 Complex 1 protein (LYR family) DUF1269 PF06897.7 ESL06090.1 - 0.069 13.1 0.7 0.54 10.3 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) DUF4650 PF15509.1 ESL06090.1 - 0.11 11.3 0.7 0.12 11.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) GNT-I PF03071.10 ESL06090.1 - 0.28 9.6 2.1 0.34 9.4 1.4 1.0 1 0 0 1 1 1 0 GNT-I family zf-ZPR1 PF03367.8 ESL06091.1 - 1.2e-105 349.5 0.0 2.3e-53 179.6 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Zn-ribbon_8 PF09723.5 ESL06091.1 - 0.00059 19.7 6.6 6.2 6.8 0.0 4.5 4 0 0 4 4 4 1 Zinc ribbon domain HypA PF01155.14 ESL06091.1 - 0.0027 17.3 2.2 0.65 9.6 0.1 2.7 2 1 0 2 2 2 2 Hydrogenase expression/synthesis hypA family zf-ISL3 PF14690.1 ESL06091.1 - 0.014 15.4 4.9 9.6 6.3 0.1 4.3 4 0 0 4 4 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-RING_3 PF14369.1 ESL06091.1 - 0.035 14.1 2.7 18 5.4 0.0 3.6 3 0 0 3 3 3 0 zinc-finger zf-DNA_Pol PF08996.5 ESL06091.1 - 0.048 13.0 2.1 2.2 7.5 0.2 2.5 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger zf-ribbon_3 PF13248.1 ESL06091.1 - 0.055 12.6 15.3 0.66 9.2 0.2 4.5 5 0 0 5 5 5 0 zinc-ribbon domain DnaJ_CXXCXGXG PF00684.14 ESL06091.1 - 0.097 12.7 4.1 2.7 8.0 0.2 2.6 2 0 0 2 2 2 0 DnaJ central domain UPF0547 PF10571.4 ESL06091.1 - 0.1 12.3 14.5 0.11 12.1 0.2 4.1 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 Zn_Tnp_IS1595 PF12760.2 ESL06091.1 - 0.17 11.7 10.1 5.2 6.9 0.5 3.6 2 2 2 4 4 4 0 Transposase zinc-ribbon domain zf-Di19 PF05605.7 ESL06091.1 - 0.34 11.0 6.4 1.5 9.0 0.1 3.8 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Cys_rich_KTR PF14205.1 ESL06091.1 - 0.86 9.1 7.8 0.75 9.2 0.1 3.3 2 1 0 2 2 2 0 Cysteine-rich KTR Elf1 PF05129.8 ESL06091.1 - 0.94 9.2 9.5 5.7 6.7 0.1 3.4 2 2 1 3 3 3 0 Transcription elongation factor Elf1 like DUF329 PF03884.9 ESL06091.1 - 0.99 9.0 3.6 21 4.7 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF329) zf-H2C2_2 PF13465.1 ESL06091.1 - 1.4 9.3 11.5 11 6.5 0.2 4.2 4 0 0 4 4 4 0 Zinc-finger double domain DZR PF12773.2 ESL06091.1 - 2.1 8.2 11.2 3.2 7.6 1.5 3.4 2 2 1 3 3 3 0 Double zinc ribbon zf-AN1 PF01428.11 ESL06091.1 - 3.9 7.4 7.0 71 3.4 0.0 3.9 4 0 0 4 4 4 0 AN1-like Zinc finger Lar_restr_allev PF14354.1 ESL06091.1 - 4.2 7.7 10.5 16 5.9 1.5 3.8 2 2 2 4 4 4 0 Restriction alleviation protein Lar DUF1935 PF09149.5 ESL06092.1 - 5e-20 71.4 0.0 6.3e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Pribosyltran_N PF13793.1 ESL06093.1 - 1.1e-34 118.6 0.1 4.8e-34 116.5 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESL06093.1 - 1.4e-14 54.2 0.0 3e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ESL06093.1 - 4.2e-07 29.7 0.1 1.7e-06 27.7 0.0 2.1 2 1 0 2 2 2 1 Phosphoribosyl transferase domain Peptidase_M16_C PF05193.16 ESL06093.1 - 0.054 13.1 0.0 3.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Peptidase M16 inactive domain PP2C PF00481.16 ESL06094.1 - 2.7e-29 102.3 0.0 1.5e-26 93.3 0.0 3.1 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL06094.1 - 0.04 13.3 0.0 15 4.8 0.0 2.9 2 1 0 2 2 2 0 Protein phosphatase 2C SpoIIE PF07228.7 ESL06094.1 - 0.064 12.9 0.8 0.39 10.3 0.0 2.6 3 1 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) DZR PF12773.2 ESL06095.1 - 0.035 13.9 9.2 0.046 13.5 3.5 2.5 1 1 1 2 2 2 0 Double zinc ribbon mRNA_cap_enzyme PF01331.14 ESL06097.1 - 9.4e-07 28.7 1.0 5.3e-06 26.2 0.7 2.1 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain AAA_17 PF13207.1 ESL06097.1 - 5.2e-06 27.2 0.0 1.5e-05 25.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL06097.1 - 2.7e-05 24.4 0.0 6.4e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ADK PF00406.17 ESL06097.1 - 8.8e-05 22.4 0.0 0.00041 20.2 0.0 1.9 1 1 1 2 2 2 1 Adenylate kinase mRNA_cap_C PF03919.10 ESL06097.1 - 0.00085 19.6 0.0 0.0026 18.0 0.0 1.9 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain PAM2 PF07145.10 ESL06097.1 - 0.0016 17.8 0.2 0.0033 16.8 0.1 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region AAA_22 PF13401.1 ESL06097.1 - 0.0095 16.0 0.0 0.029 14.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.12 ESL06097.1 - 0.013 14.9 0.1 0.71 9.2 0.0 2.4 1 1 1 2 2 2 0 Thymidylate kinase AAA_14 PF13173.1 ESL06097.1 - 0.029 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESL06097.1 - 0.042 12.9 0.0 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.1 ESL06097.1 - 0.051 13.4 0.0 0.12 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESL06097.1 - 0.071 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase SRP54 PF00448.17 ESL06097.1 - 0.076 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Cyt-b5 PF00173.23 ESL06098.1 - 8e-40 134.5 1.1 7e-20 70.6 0.1 2.5 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Sec2p PF06428.6 ESL06099.1 - 0.93 9.3 7.9 8.9 6.2 0.0 3.4 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p DMPK_coil PF08826.5 ESL06099.1 - 3.6 7.5 11.3 0.1 12.5 1.9 2.9 3 0 0 3 3 3 0 DMPK coiled coil domain like IncA PF04156.9 ESL06099.1 - 6.8 6.2 12.5 4.4 6.8 1.0 2.8 3 0 0 3 3 3 0 IncA protein Peptidase_M8 PF01457.11 ESL06100.1 - 3.3e-44 151.1 4.4 3.4e-35 121.3 1.7 2.0 1 1 1 2 2 2 2 Leishmanolysin AMP-binding PF00501.23 ESL06101.1 - 5.9e-83 278.5 0.2 7e-83 278.3 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESL06101.1 - 2.9e-18 66.5 1.7 8.9e-18 65.0 1.2 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glycos_transf_3 PF00591.16 ESL06101.1 - 0.066 12.6 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Glutaredoxin PF00462.19 ESL06103.1 - 2.3e-14 53.1 0.1 2.8e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 ESL06103.1 - 3.5e-06 26.7 0.0 4.7e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_2 PF13098.1 ESL06103.1 - 0.00021 21.4 0.1 0.001 19.2 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.1 ESL06103.1 - 0.0016 18.4 0.1 0.26 11.2 0.0 2.0 1 1 1 2 2 2 2 Thioredoxin GST_N_3 PF13417.1 ESL06103.1 - 0.009 16.2 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.9 ESL06103.1 - 0.016 15.4 0.1 0.021 15.0 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DSBA PF01323.15 ESL06103.1 - 0.056 12.9 0.3 5.3 6.5 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF953 PF06110.6 ESL06103.1 - 0.079 12.3 0.2 0.18 11.2 0.1 1.5 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF953) ATP_bind_1 PF03029.12 ESL06104.1 - 4e-70 236.0 0.2 5.1e-70 235.7 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 ESL06104.1 - 1.7e-08 34.1 0.0 3.7e-08 33.0 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL06104.1 - 3.2e-06 27.6 0.0 0.031 14.7 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein SRP54 PF00448.17 ESL06104.1 - 1.2e-05 24.8 0.0 6.3e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_24 PF13479.1 ESL06104.1 - 2.3e-05 24.1 0.0 3.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL06104.1 - 4.4e-05 23.3 0.4 0.00013 21.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESL06104.1 - 5.3e-05 23.2 0.0 0.00017 21.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.18 ESL06104.1 - 0.00015 21.2 0.1 0.00037 19.9 0.0 1.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.18 ESL06104.1 - 0.00016 21.6 0.1 0.00034 20.5 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL06104.1 - 0.00025 20.3 0.0 0.091 12.0 0.0 3.2 3 0 0 3 3 3 1 Ferrous iron transport protein B AAA_22 PF13401.1 ESL06104.1 - 0.00029 20.9 0.0 0.0011 19.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESL06104.1 - 0.00074 19.2 0.2 0.0017 18.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESL06104.1 - 0.00082 19.0 0.0 0.0022 17.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain ArgK PF03308.11 ESL06104.1 - 0.0011 17.8 0.0 0.078 11.7 0.0 2.4 3 0 0 3 3 2 1 ArgK protein MobB PF03205.9 ESL06104.1 - 0.0014 18.3 0.0 0.0091 15.7 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 ESL06104.1 - 0.0015 18.1 0.3 0.0041 16.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 ESL06104.1 - 0.0015 18.0 0.4 0.021 14.2 0.3 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 ESL06104.1 - 0.0028 17.1 0.0 0.043 13.3 0.0 2.6 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 ESL06104.1 - 0.0035 17.0 0.3 0.0065 16.1 0.2 1.8 1 1 0 1 1 1 1 NACHT domain SRPRB PF09439.5 ESL06104.1 - 0.0037 16.4 0.0 0.48 9.6 0.0 2.2 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.7 ESL06104.1 - 0.0037 16.3 0.0 0.0064 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Arf PF00025.16 ESL06104.1 - 0.004 16.4 0.0 0.11 11.7 0.0 2.5 2 1 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.1 ESL06104.1 - 0.0048 16.8 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.17 ESL06104.1 - 0.0051 15.7 0.0 0.0079 15.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Ras PF00071.17 ESL06104.1 - 0.0071 15.7 0.1 0.21 10.9 0.0 2.4 1 1 1 2 2 2 1 Ras family AAA_17 PF13207.1 ESL06104.1 - 0.0082 16.9 0.0 0.016 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 ESL06104.1 - 0.0096 14.9 0.0 0.024 13.6 0.0 1.7 1 1 0 1 1 1 1 KAP family P-loop domain Sigma54_activat PF00158.21 ESL06104.1 - 0.017 14.6 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Septin PF00735.13 ESL06104.1 - 0.019 14.0 0.1 0.069 12.1 0.1 1.9 1 1 0 1 1 1 0 Septin PhoH PF02562.11 ESL06104.1 - 0.023 13.9 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.12 ESL06104.1 - 0.028 13.8 0.0 0.063 12.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein G-alpha PF00503.15 ESL06104.1 - 0.04 12.5 0.0 1.9 7.1 0.0 2.5 2 0 0 2 2 2 0 G-protein alpha subunit DUF2075 PF09848.4 ESL06104.1 - 0.051 12.5 0.0 0.075 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 ESL06104.1 - 0.058 12.5 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.10 ESL06104.1 - 0.071 12.8 0.1 0.18 11.5 0.1 1.8 1 1 0 1 1 1 0 NTPase AAA_35 PF14516.1 ESL06104.1 - 0.073 11.6 0.0 0.17 10.4 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain DUF258 PF03193.11 ESL06104.1 - 0.075 12.2 0.1 0.85 8.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA PF00004.24 ESL06104.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.15 ESL06104.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase LSM PF01423.17 ESL06105.1 - 1.5e-10 40.4 0.1 1.9e-10 40.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESL06105.1 - 1e-05 25.3 0.2 1.4e-05 24.8 0.2 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Tail_tube PF10618.4 ESL06105.1 - 0.1 12.3 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Phage tail tube protein PUF PF00806.14 ESL06106.1 - 0.0063 15.9 0.0 9.2 5.9 0.0 4.2 4 0 0 4 4 4 1 Pumilio-family RNA binding repeat TMCO5 PF14992.1 ESL06107.1 - 0.13 11.3 6.1 0.15 11.1 3.4 1.6 1 1 0 1 1 1 0 TMCO5 family DUF972 PF06156.8 ESL06107.1 - 1.1 9.6 7.8 4.7 7.5 3.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF972) DUF3138 PF11336.3 ESL06107.1 - 2.5 6.1 7.7 0.48 8.5 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) DUF342 PF03961.8 ESL06107.1 - 3.5 5.9 5.1 2.4 6.4 2.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF342) zf-DHHC PF01529.15 ESL06109.1 - 3e-28 98.3 5.6 3e-28 98.3 3.9 2.4 1 1 1 2 2 2 2 DHHC palmitoyltransferase UCH PF00443.24 ESL06110.1 - 6.4e-48 163.1 0.0 9.4e-48 162.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL06110.1 - 4.2e-18 65.8 0.0 9e-18 64.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 ESL06110.1 - 1.3e-16 60.4 5.9 1.3e-16 60.4 4.1 5.0 5 0 0 5 5 5 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 ESL06110.1 - 1.2e-07 31.3 0.6 3.2e-07 29.9 0.4 1.8 1 0 0 1 1 1 1 UBA/TS-N domain ThiI PF02568.9 ESL06110.1 - 0.0055 16.1 0.0 0.068 12.6 0.0 2.2 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) PolC_DP2 PF03833.8 ESL06110.1 - 1.2 6.7 3.8 1.8 6.1 2.7 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 60KD_IMP PF02096.15 ESL06111.1 - 1.5e-13 50.8 0.0 2e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Complex1_LYR PF05347.10 ESL06113.1 - 7.6e-05 22.4 0.3 7.6e-05 22.4 0.2 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESL06113.1 - 0.00027 21.0 0.3 0.0005 20.2 0.2 1.4 1 0 0 1 1 1 1 Complex1_LYR-like Kinesin PF00225.18 ESL06114.1 - 1.4e-53 181.7 2.0 1.6e-53 181.6 1.4 1.0 1 0 0 1 1 1 1 Kinesin motor domain Pkinase PF00069.20 ESL06116.1 - 2.1e-50 171.3 0.0 3.3e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06116.1 - 1.3e-21 76.8 0.0 3.2e-20 72.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESL06116.1 - 0.01 14.6 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase PF00069.20 ESL06117.1 - 2.4e-48 164.5 0.0 3.1e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06117.1 - 1e-23 83.7 0.0 1.5e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06117.1 - 7.2e-07 28.4 0.0 1.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL06117.1 - 6.5e-06 26.0 1.1 1.4e-05 24.9 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESL06117.1 - 0.0018 17.1 0.0 0.0029 16.4 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Choline_kinase PF01633.15 ESL06117.1 - 0.095 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.17 ESL06117.1 - 0.12 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 RIO1 family eRF1_2 PF03464.10 ESL06118.1 - 1.3e-35 122.5 0.0 7.7e-35 120.1 0.0 2.0 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_1 PF03463.10 ESL06118.1 - 5e-23 81.1 0.1 7.2e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 eRF1 domain 1 TPK_B1_binding PF04265.9 ESL06119.1 - 5.2e-12 45.2 0.0 9.3e-12 44.4 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.11 ESL06119.1 - 5.4e-09 35.6 0.0 0.0033 17.0 0.0 3.2 3 0 0 3 3 3 3 Thiamin pyrophosphokinase, catalytic domain MAPKK1_Int PF08923.5 ESL06121.1 - 0.043 13.4 0.0 7.1 6.2 0.0 2.1 2 0 0 2 2 2 0 Mitogen-activated protein kinase kinase 1 interacting SLBP_RNA_bind PF15247.1 ESL06123.1 - 3.1e-24 84.5 3.8 9.7e-24 82.9 2.6 1.8 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain GRASP55_65 PF04495.9 ESL06125.1 - 5.1e-44 149.6 0.0 8.2e-30 103.5 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.1 ESL06125.1 - 0.0044 16.8 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 ESL06125.1 - 0.0049 17.0 0.1 0.05 13.7 0.0 2.5 3 0 0 3 3 3 1 PDZ domain (Also known as DHR or GLGF) CRM1_C PF08767.6 ESL06126.1 - 8.8e-61 205.5 1.3 2.4e-60 204.1 0.0 2.3 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.7 ESL06126.1 - 3.6e-27 95.0 0.1 3.4e-25 88.6 0.0 3.4 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.14 ESL06126.1 - 8e-08 32.0 0.1 2.3e-07 30.6 0.1 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain FHA PF00498.21 ESL06127.1 - 7.9e-10 38.7 0.0 1.6e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain BRCT PF00533.21 ESL06127.1 - 7.6e-06 25.9 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 ESL06127.1 - 0.031 14.1 0.0 0.075 12.9 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain Mo25 PF08569.6 ESL06128.1 - 3.3e-73 246.6 0.0 3.9e-73 246.3 0.0 1.0 1 0 0 1 1 1 1 Mo25-like Peptidase_M8 PF01457.11 ESL06130.1 - 4.1e-54 183.8 0.0 4.6e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin COQ7 PF03232.8 ESL06131.1 - 0.016 14.6 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 Abhydrolase_9 PF10081.4 ESL06131.1 - 0.03 13.0 0.1 0.038 12.7 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family IFT20 PF14931.1 ESL06132.1 - 1.8e-39 134.3 7.7 2.1e-39 134.1 5.3 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 Pex19 PF04614.7 ESL06132.1 - 0.058 13.0 0.7 0.071 12.7 0.5 1.2 1 0 0 1 1 1 0 Pex19 protein family DUF3025 PF11227.3 ESL06132.1 - 0.098 12.1 0.1 0.13 11.7 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3025) 4HB_MCP_1 PF12729.2 ESL06132.1 - 0.18 11.1 4.4 0.36 10.1 2.8 1.7 1 1 0 1 1 1 0 Four helix bundle sensory module for signal transduction Latarcin PF10279.4 ESL06132.1 - 0.82 9.9 4.7 8 6.7 0.1 2.2 1 1 1 2 2 2 0 Latarcin precursor TPR_2 PF07719.12 ESL06133.1 - 0.0014 18.3 1.1 0.084 12.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06133.1 - 0.0025 17.4 0.4 0.054 13.1 0.1 2.3 1 1 0 2 2 2 1 TPR repeat GTPase_Cys_C PF12631.2 ESL06133.1 - 0.11 12.8 0.8 25 5.3 0.0 2.9 3 0 0 3 3 3 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE CEP44 PF15007.1 ESL06134.1 - 0.0029 17.3 0.0 0.0036 17.0 0.0 1.1 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 Arf PF00025.16 ESL06135.1 - 8.5e-64 213.9 0.0 9.4e-64 213.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESL06135.1 - 3.4e-16 58.9 0.0 4.1e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 ESL06135.1 - 2e-14 53.3 0.0 2.2e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 ESL06135.1 - 3.2e-14 52.4 0.3 5.3e-11 41.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 ESL06135.1 - 5.1e-12 45.4 0.0 5.9e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESL06135.1 - 1e-11 45.3 0.0 1.4e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESL06135.1 - 6.8e-10 38.9 0.0 9.2e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL06135.1 - 5.3e-05 22.7 0.0 0.00077 18.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 ESL06135.1 - 0.027 13.9 0.0 0.053 13.0 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.24 ESL06135.1 - 0.062 13.5 0.0 0.2 11.8 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 ESL06135.1 - 0.082 11.6 0.1 0.77 8.4 0.1 2.1 1 1 0 1 1 1 0 ArgK protein AAA_16 PF13191.1 ESL06135.1 - 0.086 12.8 0.1 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Arch_ATPase PF01637.13 ESL06135.1 - 0.11 12.1 0.1 0.21 11.2 0.0 1.4 2 0 0 2 2 2 0 Archaeal ATPase AAA_18 PF13238.1 ESL06135.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain Ribosomal_S11 PF00411.14 ESL06136.1 - 2.1e-30 105.1 1.4 2.4e-30 104.9 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 zf-CCCH PF00642.19 ESL06137.1 - 0.051 13.2 7.3 5.3 6.8 2.8 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RmlD_sub_bind PF04321.12 ESL06138.1 - 2e-05 23.6 0.0 0.034 13.0 0.0 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.1 ESL06138.1 - 5.4e-05 23.2 0.0 9.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESL06138.1 - 0.064 12.5 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Dynamin_N PF00350.18 ESL06139.1 - 6.7e-17 61.8 0.0 1.2e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESL06139.1 - 1.2e-09 38.0 0.0 3.2e-09 36.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL06139.1 - 7.6e-05 23.1 0.0 0.0078 16.7 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein DUF258 PF03193.11 ESL06139.1 - 0.00014 21.0 0.3 0.0021 17.2 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESL06139.1 - 0.00064 19.2 0.2 0.2 11.0 0.0 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESL06139.1 - 0.0049 16.1 0.0 0.69 9.1 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.11 ESL06139.1 - 0.0092 15.1 0.1 3.6 6.6 0.0 2.7 3 0 0 3 3 3 2 AIG1 family AAA_33 PF13671.1 ESL06139.1 - 0.024 14.5 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESL06139.1 - 0.048 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Arf PF00025.16 ESL06139.1 - 0.16 11.2 0.0 0.66 9.1 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family MSP1_C PF07462.6 ESL06139.1 - 0.57 8.4 1.5 0.83 7.9 1.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Kinesin PF00225.18 ESL06140.1 - 6.3e-91 304.5 0.0 8.3e-91 304.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain RecO_C PF02565.10 ESL06140.1 - 0.047 13.5 0.1 0.095 12.5 0.0 1.4 1 0 0 1 1 1 0 Recombination protein O C terminal PPR_2 PF13041.1 ESL06142.1 - 6.9e-07 29.1 0.0 1.3e-05 25.0 0.0 2.5 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.1 ESL06142.1 - 1.5e-05 24.8 2.5 1.6 9.1 0.0 5.5 6 1 0 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESL06142.1 - 0.003 16.9 0.3 0.73 9.3 0.0 2.8 2 1 0 2 2 2 2 PPR repeat LicD PF04991.8 ESL06143.1 - 2.7e-17 63.5 0.0 6.6e-16 59.0 0.0 2.6 1 1 0 1 1 1 1 LicD family Shal-type PF11601.3 ESL06143.1 - 2.9 7.4 8.3 0.19 11.2 0.6 2.8 2 0 0 2 2 2 0 Shal-type voltage-gated potassium channels EF-hand_1 PF00036.27 ESL06144.1 - 2.1e-14 51.6 14.7 4.8e-06 25.4 0.0 5.0 4 1 1 5 5 5 3 EF hand EF-hand_6 PF13405.1 ESL06144.1 - 1.6e-13 49.3 8.0 0.00024 20.7 0.2 4.3 4 1 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 ESL06144.1 - 1.8e-12 47.1 4.4 6.5e-07 29.3 0.3 3.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL06144.1 - 9.6e-09 34.7 11.0 0.00034 20.1 0.2 3.9 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 ESL06144.1 - 1e-08 34.0 0.3 0.00036 19.7 0.0 5.0 5 1 0 5 5 5 2 EF hand EF-hand_10 PF14788.1 ESL06144.1 - 0.0063 16.1 1.8 3.6 7.3 0.0 3.5 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.4 ESL06144.1 - 0.057 13.4 0.4 0.2 11.6 0.1 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region STOP PF05217.7 ESL06145.1 - 5.7e-06 26.2 2.7 0.00035 20.3 0.1 2.2 1 1 1 2 2 2 2 STOP protein Ribosomal_L15e PF00827.12 ESL06149.1 - 9.9e-88 292.6 10.8 1.1e-87 292.4 7.5 1.0 1 0 0 1 1 1 1 Ribosomal L15 Pkinase PF00069.20 ESL06151.1 - 1.7e-66 224.0 0.0 1.7e-66 224.0 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06151.1 - 6.5e-43 146.6 0.0 1.2e-42 145.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06151.1 - 1.1e-06 27.8 0.0 2.9e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.27 ESL06153.1 - 3e-07 30.0 7.3 0.014 15.2 0.1 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat LRR_6 PF13516.1 ESL06153.1 - 0.045 13.8 0.1 39 4.7 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich repeat RRM_1 PF00076.17 ESL06154.1 - 9.3e-05 21.9 0.0 0.1 12.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06154.1 - 0.0077 16.1 0.1 0.24 11.3 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06154.1 - 0.0094 15.7 0.1 0.059 13.2 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_2 PF07716.10 ESL06154.1 - 0.19 11.5 4.5 16 5.3 0.0 2.9 2 0 0 2 2 2 0 Basic region leucine zipper DUF972 PF06156.8 ESL06154.1 - 0.23 11.7 2.2 20 5.5 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Tropomyosin_1 PF12718.2 ESL06154.1 - 0.39 10.5 14.6 0.045 13.5 3.4 2.7 3 0 0 3 3 3 0 Tropomyosin like CK2S PF15011.1 ESL06154.1 - 0.99 9.1 11.7 0.43 10.3 3.0 2.4 2 0 0 2 2 2 0 Casein Kinase 2 substrate DUF724 PF05266.9 ESL06154.1 - 4.8 6.7 10.3 0.47 10.0 2.8 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Viral_P18 PF04521.8 ESL06154.1 - 4.9 6.6 6.3 1.2 8.5 0.2 2.6 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Laminin_II PF06009.7 ESL06154.1 - 5.1 6.8 15.7 3 7.6 2.3 2.9 3 0 0 3 3 3 0 Laminin Domain II DivIC PF04977.10 ESL06154.1 - 9.5 5.7 9.1 6.1 6.4 0.1 3.2 2 2 0 2 2 2 0 Septum formation initiator DUF914 PF06027.7 ESL06155.1 - 2e-09 36.7 8.5 2.3e-09 36.5 5.9 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) Ndc1_Nup PF09531.5 ESL06155.1 - 0.088 11.2 9.7 0.1 10.9 6.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EamA PF00892.15 ESL06155.1 - 0.18 11.8 14.2 0.23 11.4 9.8 1.1 1 0 0 1 1 1 0 EamA-like transporter family Ureide_permease PF07168.6 ESL06155.1 - 0.32 9.6 5.8 0.21 10.1 3.3 1.2 1 1 0 1 1 1 0 Ureide permease Iso_dh PF00180.15 ESL06156.1 - 1.2e-67 228.3 0.0 1.4e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase FAM194 PF14977.1 ESL06156.1 - 0.12 11.3 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 FAM194 protein DUF4206 PF13901.1 ESL06157.1 - 6.8e-18 64.9 17.1 1.2e-13 51.0 0.3 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF4206) UPF0449 PF15136.1 ESL06157.1 - 0.17 12.0 1.3 0.33 11.1 0.2 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF4200 PF13863.1 ESL06157.1 - 0.61 10.0 6.4 1.2 9.0 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) NUC153 PF08159.7 ESL06158.1 - 0.13 11.8 0.9 0.72 9.5 0.1 2.6 2 1 0 2 2 2 0 NUC153 domain DUF3748 PF12566.3 ESL06158.1 - 0.2 11.5 2.6 2 8.3 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3748) PGA2 PF07543.7 ESL06158.1 - 8.7 6.1 13.2 0.13 12.0 3.2 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 Ribosomal_L3 PF00297.17 ESL06159.1 - 1.5e-84 283.5 7.8 1.9e-84 283.1 5.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 WD40 PF00400.27 ESL06160.1 - 5.2e-10 38.8 3.2 0.00056 19.6 0.1 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat DUF3522 PF12036.3 ESL06160.1 - 0.036 13.8 0.5 0.063 13.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3522) ADK PF00406.17 ESL06161.1 - 1.7e-25 89.6 0.0 2.9e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESL06161.1 - 1.6e-08 35.4 0.0 7.6e-08 33.1 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 ESL06161.1 - 4.8e-07 29.7 0.0 1.3e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain SKI PF01202.17 ESL06161.1 - 0.00058 19.7 0.3 0.057 13.2 0.0 3.0 3 1 1 4 4 4 1 Shikimate kinase Thymidylate_kin PF02223.12 ESL06161.1 - 0.0012 18.3 0.0 1.1 8.5 0.0 3.1 2 1 0 3 3 3 1 Thymidylate kinase AAA_18 PF13238.1 ESL06161.1 - 0.0026 18.0 0.0 0.0067 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL06161.1 - 0.013 15.4 0.0 0.053 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.10 ESL06161.1 - 0.015 14.0 0.0 0.02 13.5 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 ESL06161.1 - 0.015 15.0 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ADK_lid PF05191.9 ESL06161.1 - 0.019 14.6 0.1 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid AAA PF00004.24 ESL06161.1 - 0.027 14.6 0.0 0.053 13.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 ESL06161.1 - 0.044 13.7 0.1 0.15 11.9 0.0 2.0 3 0 0 3 3 3 0 AAA domain CoaE PF01121.15 ESL06161.1 - 0.06 12.7 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_19 PF13245.1 ESL06161.1 - 0.089 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain RIIa PF02197.12 ESL06161.1 - 0.1 12.0 1.8 0.2 11.1 0.2 2.3 1 1 1 2 2 2 0 Regulatory subunit of type II PKA R-subunit Zeta_toxin PF06414.7 ESL06161.1 - 0.13 11.3 0.0 0.31 10.1 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin DKCLD PF08068.7 ESL06163.1 - 2.1e-27 94.7 0.1 5.8e-26 90.1 0.1 2.7 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 ESL06163.1 - 1.4e-22 80.4 2.3 3.2e-19 69.5 1.6 3.1 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 ESL06163.1 - 4.8e-19 67.8 0.6 1.2e-18 66.5 0.4 1.7 1 0 0 1 1 1 1 PUA domain AAA_18 PF13238.1 ESL06164.1 - 1.1e-08 35.4 0.0 1.7e-07 31.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL06164.1 - 1.4e-05 25.8 0.1 2.9e-05 24.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 ESL06164.1 - 4.5e-05 23.1 0.0 0.21 11.1 0.0 2.1 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 ESL06164.1 - 0.00013 21.1 0.0 0.00027 20.0 0.0 1.5 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.17 ESL06164.1 - 0.00066 18.6 0.0 0.025 13.4 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain RuvB_N PF05496.7 ESL06164.1 - 0.00068 18.7 0.0 0.00096 18.2 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus ArgK PF03308.11 ESL06164.1 - 0.0014 17.4 0.1 0.0024 16.6 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_19 PF13245.1 ESL06164.1 - 0.0029 17.3 0.0 0.0055 16.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain ABC_tran PF00005.22 ESL06164.1 - 0.0038 17.5 0.0 0.005 17.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.1 ESL06164.1 - 0.0053 16.6 0.0 0.011 15.6 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA PF00004.24 ESL06164.1 - 0.0062 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.5 ESL06164.1 - 0.0086 15.3 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Sigma54_activ_2 PF14532.1 ESL06164.1 - 0.018 15.0 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain Thymidylate_kin PF02223.12 ESL06164.1 - 0.02 14.2 0.0 0.69 9.2 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_16 PF13191.1 ESL06164.1 - 0.027 14.4 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Torsin PF06309.6 ESL06164.1 - 0.028 14.2 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Torsin AAA_30 PF13604.1 ESL06164.1 - 0.047 13.2 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL06164.1 - 0.053 13.7 0.0 0.093 12.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase T2SE PF00437.15 ESL06164.1 - 0.053 12.4 0.0 0.08 11.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 ESL06164.1 - 0.06 13.4 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESL06164.1 - 0.062 12.0 0.1 0.092 11.4 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus NTPase_1 PF03266.10 ESL06164.1 - 0.073 12.7 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 1 0 NTPase SKI PF01202.17 ESL06164.1 - 0.079 12.8 0.0 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase CoaE PF01121.15 ESL06164.1 - 0.08 12.3 0.2 0.17 11.2 0.1 1.8 2 1 0 2 2 2 0 Dephospho-CoA kinase AAA_25 PF13481.1 ESL06164.1 - 0.081 12.3 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 ESL06164.1 - 0.082 11.5 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DnaB_C PF03796.10 ESL06164.1 - 0.15 10.8 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Vps51 PF08700.6 ESL06165.1 - 4.6e-14 52.0 4.8 1.1e-12 47.6 0.1 2.9 2 0 0 2 2 2 2 Vps51/Vps67 HORMA PF02301.13 ESL06166.1 - 5.4e-51 173.0 0.0 7.1e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 HORMA domain RRM_1 PF00076.17 ESL06167.1 - 9.1e-19 66.8 0.2 2.1e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06167.1 - 3.4e-10 39.7 0.1 7.1e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06167.1 - 5.5e-08 32.5 0.1 1.2e-05 25.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CPSF_A PF03178.10 ESL06168.1 - 1.6e-16 60.3 0.0 4e-15 55.7 0.0 2.6 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.4 ESL06168.1 - 8.5e-15 53.8 0.0 2.5e-05 22.6 0.0 3.3 3 0 0 3 3 3 3 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF2428 PF10350.4 ESL06170.1 - 6.7e-54 182.5 0.1 1.3e-53 181.6 0.0 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HR1 PF02185.11 ESL06170.1 - 0.02 14.6 2.1 0.066 12.9 1.4 1.9 1 0 0 1 1 1 0 Hr1 repeat HEAT PF02985.17 ESL06170.1 - 0.035 14.1 3.4 15 5.9 0.2 5.9 5 0 0 5 5 5 0 HEAT repeat HlyIII PF03006.15 ESL06171.1 - 1e-52 178.7 26.2 1.2e-52 178.5 18.2 1.0 1 0 0 1 1 1 1 Haemolysin-III related NfeD PF01957.13 ESL06171.1 - 0.55 10.3 2.5 2.9 8.0 0.1 2.6 3 0 0 3 3 3 0 NfeD-like C-terminal, partner-binding SET PF00856.23 ESL06172.1 - 1.9e-11 44.5 0.0 3.8e-11 43.5 0.0 1.5 1 1 0 1 1 1 1 SET domain GNAT_acetyltr_2 PF13718.1 ESL06173.1 - 4.6e-71 238.1 0.0 8.4e-71 237.3 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 ESL06173.1 - 6.9e-61 204.9 0.0 2.5e-60 203.1 0.0 2.0 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 ESL06173.1 - 1.8e-36 123.6 0.1 7.1e-36 121.7 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 ESL06173.1 - 8.9e-21 73.8 0.2 2.2e-20 72.6 0.1 1.7 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 ESL06173.1 - 0.00042 20.4 0.0 0.002 18.2 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_22 PF13401.1 ESL06173.1 - 0.01 15.9 0.0 1.1 9.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 ESL06173.1 - 0.033 13.7 4.5 3.3 7.2 0.3 3.4 3 1 0 3 3 3 0 AAA domain zf-RING_2 PF13639.1 ESL06174.1 - 2.2e-11 43.3 17.9 5e-11 42.2 12.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESL06174.1 - 7.9e-07 29.1 11.3 7.9e-07 29.1 7.8 1.7 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESL06174.1 - 2.1e-06 27.6 13.7 4.4e-06 26.6 9.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL06174.1 - 0.00011 21.7 14.3 0.00011 21.7 9.9 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL06174.1 - 0.00039 20.0 13.9 0.00076 19.0 9.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESL06174.1 - 0.0012 18.5 8.3 0.0026 17.4 5.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESL06174.1 - 0.0027 17.4 16.4 0.0067 16.1 11.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Rtf2 PF04641.7 ESL06174.1 - 0.0045 16.2 1.1 0.0071 15.5 0.8 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Apc11 PF12861.2 ESL06174.1 - 0.0056 16.4 7.5 0.013 15.3 5.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 ESL06174.1 - 0.0064 16.4 12.8 0.096 12.6 8.8 2.3 1 1 0 1 1 1 1 FANCL C-terminal domain Peptidase_S15 PF02129.13 ESL06176.1 - 4.1e-59 200.2 1.6 5.8e-59 199.7 1.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 ESL06176.1 - 7e-34 117.6 0.1 1e-33 117.0 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_6 PF12697.2 ESL06176.1 - 3.1e-13 50.1 0.4 8.5e-13 48.7 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL06176.1 - 7.3e-10 38.7 0.0 3.8e-09 36.4 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESL06176.1 - 3.4e-09 36.2 1.3 3.4e-08 32.9 0.5 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 ESL06176.1 - 1.7e-05 24.5 0.1 4.6e-05 23.0 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESL06176.1 - 0.0001 22.0 0.0 0.00022 21.0 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase AXE1 PF05448.7 ESL06176.1 - 0.00018 20.0 0.0 0.0015 17.1 0.0 2.0 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) DLH PF01738.13 ESL06176.1 - 0.12 11.5 0.0 0.3 10.3 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family GET2 PF08690.5 ESL06177.1 - 0.21 10.7 2.7 0.24 10.6 1.8 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 HMG_box PF00505.14 ESL06177.1 - 1.2 9.3 9.3 12 6.3 0.1 2.6 2 1 0 2 2 2 0 HMG (high mobility group) box MFS_1 PF07690.11 ESL06180.1 - 3.3e-26 91.8 48.2 2e-25 89.3 33.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 ESL06180.1 - 4.6e-10 38.1 33.5 1.1e-05 23.7 2.4 4.4 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family Lig_chan PF00060.21 ESL06180.1 - 0.072 12.8 1.4 0.78 9.4 0.1 2.9 2 1 0 2 2 2 0 Ligand-gated ion channel DUF3639 PF12341.3 ESL06181.1 - 0.01 15.8 0.2 0.095 12.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3639) HEAT_2 PF13646.1 ESL06182.1 - 3.6e-29 100.8 8.8 4.4e-16 58.9 1.7 3.5 1 1 2 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 ESL06182.1 - 1.4e-19 68.4 7.8 0.00034 20.8 0.2 6.7 7 0 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT PF02985.17 ESL06182.1 - 3.6e-06 26.6 4.9 0.0085 16.0 0.1 5.1 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.1 ESL06182.1 - 0.0033 17.8 9.1 0.01 16.2 2.1 4.2 4 1 1 5 5 5 1 HEAT-like repeat TPR_11 PF13414.1 ESL06183.1 - 1.1e-26 92.2 26.1 1.8e-10 40.3 3.4 4.4 2 2 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 ESL06183.1 - 2.4e-24 83.8 11.0 9.1e-06 25.0 0.1 5.8 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06183.1 - 4.4e-24 82.4 15.7 1.6e-05 24.4 0.0 5.8 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06183.1 - 2.6e-13 49.7 14.7 3.5e-05 23.6 0.7 4.7 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06183.1 - 3.7e-12 45.1 6.8 0.0032 17.1 0.0 5.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06183.1 - 7.5e-12 44.7 15.3 0.0013 19.1 0.1 6.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06183.1 - 1.5e-10 41.4 13.6 6.2e-05 23.5 3.6 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06183.1 - 9e-10 38.7 12.1 6.6e-05 23.1 3.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL06183.1 - 4.2e-05 23.6 13.8 0.0032 17.5 3.4 3.3 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESL06183.1 - 0.0001 22.2 16.3 0.45 10.8 0.1 6.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL06183.1 - 0.00017 21.4 9.1 0.0076 16.0 0.7 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06183.1 - 0.0016 18.8 9.0 0.062 13.7 0.0 4.9 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06183.1 - 0.0039 16.8 13.7 9.1 6.3 0.1 6.0 5 1 1 6 6 6 0 Tetratricopeptide repeat MIT PF04212.13 ESL06183.1 - 0.017 14.9 5.6 0.14 12.0 0.6 3.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_20 PF14561.1 ESL06183.1 - 0.027 14.6 13.3 0.17 12.0 0.4 4.0 3 1 2 5 5 5 0 Tetratricopeptide repeat MAS20 PF02064.10 ESL06183.1 - 0.028 14.3 1.2 0.2 11.5 0.0 2.6 2 1 1 3 3 3 0 MAS20 protein import receptor zf-CCHC PF00098.18 ESL06183.1 - 0.052 13.5 1.4 0.052 13.5 1.0 1.8 2 0 0 2 2 1 0 Zinc knuckle OSCP PF00213.13 ESL06183.1 - 0.094 12.5 1.2 0.13 12.0 0.1 1.8 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit BTAD PF03704.12 ESL06183.1 - 0.23 11.7 16.1 1.7 8.8 1.9 3.9 2 2 0 2 2 2 0 Bacterial transcriptional activator domain Apc5 PF12862.2 ESL06183.1 - 0.24 11.2 3.9 0.075 12.8 0.3 2.1 2 2 1 3 3 2 0 Anaphase-promoting complex subunit 5 U1snRNP70_N PF12220.3 ESL06183.1 - 0.27 11.5 2.9 1.1 9.6 1.0 2.4 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Adeno_VII PF03228.9 ESL06183.1 - 0.3 11.6 4.3 0.14 12.7 0.8 2.0 2 0 0 2 2 2 0 Adenoviral core protein VII TPR_10 PF13374.1 ESL06183.1 - 3.2 7.8 20.9 0.33 10.9 0.4 5.3 6 1 1 7 7 6 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL06184.1 - 9.2e-79 264.2 0.0 1e-78 264.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06184.1 - 3.5e-36 124.5 0.0 5.2e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL06184.1 - 0.00049 19.9 0.2 0.0026 17.5 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESL06184.1 - 0.053 12.8 0.0 0.082 12.2 0.0 1.3 1 1 0 1 1 1 0 RIO1 family RRM_1 PF00076.17 ESL06185.1 - 2e-12 46.5 0.0 3.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06185.1 - 6.4e-08 32.4 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06185.1 - 4.5e-07 29.6 0.0 7.8e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_14 PF13173.1 ESL06186.1 - 0.0019 18.1 0.0 0.0041 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL06186.1 - 0.021 14.7 0.0 0.051 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RecA PF00154.16 ESL06186.1 - 0.03 13.4 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Arch_ATPase PF01637.13 ESL06186.1 - 0.034 13.8 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_25 PF13481.1 ESL06186.1 - 0.079 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain CobU PF02283.11 ESL06186.1 - 0.13 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Myosin_head PF00063.16 ESL06188.1 - 4.4e-160 534.0 0.0 7.4e-160 533.2 0.0 1.4 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_30 PF13604.1 ESL06188.1 - 0.017 14.7 0.1 0.017 14.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 ESL06188.1 - 0.022 14.8 0.0 0.091 12.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESL06188.1 - 0.027 14.2 0.2 0.47 10.2 0.0 3.1 3 0 0 3 3 3 0 Part of AAA domain AAA_10 PF12846.2 ESL06188.1 - 0.076 12.4 0.9 6.5 6.0 0.3 2.5 2 0 0 2 2 2 0 AAA-like domain Cnl2_NKP2 PF09447.5 ESL06188.1 - 0.13 11.9 1.3 2.3 7.9 0.6 2.6 2 0 0 2 2 2 0 Cnl2/NKP2 family protein Arf PF00025.16 ESL06189.1 - 2.7e-30 104.8 0.0 3.9e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESL06189.1 - 9.1e-10 37.7 0.0 1.9e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.5 ESL06189.1 - 4.5e-08 32.5 0.0 7.8e-08 31.7 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL06189.1 - 2.2e-07 30.8 0.0 5.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 ESL06189.1 - 2.1e-05 24.0 0.0 3.6e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Ras family GTP_EFTU PF00009.22 ESL06189.1 - 0.00028 20.3 1.1 0.009 15.4 0.2 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL06189.1 - 0.00059 20.3 0.0 0.0039 17.6 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL06189.1 - 0.023 13.8 0.0 0.043 12.9 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Radial_spoke PF04712.7 ESL06189.1 - 0.073 11.8 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 Radial spokehead-like protein FeoB_N PF02421.13 ESL06189.1 - 0.099 11.9 0.1 0.2 10.8 0.1 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Methyltransf_26 PF13659.1 ESL06191.1 - 4.1e-05 23.5 0.1 0.00019 21.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain ERG4_ERG24 PF01222.12 ESL06192.1 - 5e-103 344.9 19.3 6.3e-103 344.6 13.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Metallophos PF00149.23 ESL06193.1 - 2.6e-33 115.1 0.0 3.5e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF59 PF01883.14 ESL06194.1 - 0.016 15.2 0.2 3.8 7.5 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function DUF59 Pkinase PF00069.20 ESL06195.1 - 4e-43 147.4 0.0 4.4e-38 130.9 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06195.1 - 2.3e-21 76.0 0.0 5.9e-21 74.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 ESL06195.1 - 0.011 14.7 0.0 0.03 13.3 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EIAV_Rev PF11129.3 ESL06196.1 - 0.035 14.1 1.3 0.093 12.7 0.3 1.9 2 0 0 2 2 2 0 Rev protein of equine infectious anaemia virus Herpes_capsid PF06112.6 ESL06196.1 - 0.12 12.4 4.1 0.34 10.9 0.6 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein APC_CDC26 PF10471.4 ESL06196.1 - 0.71 10.6 8.6 0.16 12.7 1.7 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex APC subunit 1 4HBT_2 PF13279.1 ESL06197.1 - 2.3e-08 34.5 0.0 3.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 ESL06197.1 - 3.5e-06 27.0 0.0 6.4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.12 ESL06197.1 - 0.049 12.5 0.0 0.067 12.1 0.0 1.3 1 0 0 1 1 1 0 Acyl-ACP thioesterase Sec20 PF03908.8 ESL06199.1 - 2.2e-07 30.4 2.3 5.1e-07 29.3 1.6 1.6 1 0 0 1 1 1 1 Sec20 Hpt PF01627.18 ESL06199.1 - 5.8 6.9 8.6 6.1 6.9 2.7 2.8 2 1 0 2 2 2 0 Hpt domain Nrap PF03813.9 ESL06200.1 - 4.8e-68 229.6 0.1 3.2e-64 217.0 0.0 2.5 2 1 0 2 2 2 2 Nrap protein Cnd1 PF12717.2 ESL06202.1 - 7.3e-42 143.2 8.8 4.9e-37 127.4 0.0 5.2 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 ESL06202.1 - 1.6e-06 27.6 11.1 1.4 9.2 0.0 7.5 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.1 ESL06202.1 - 2.9e-06 27.4 0.4 0.64 10.3 0.0 4.9 3 1 1 4 4 4 3 HEAT repeats Cnd1_N PF12922.2 ESL06202.1 - 4.9e-06 26.2 0.2 1.2e-05 25.0 0.1 1.7 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_EZ PF13513.1 ESL06202.1 - 0.00021 21.6 0.1 0.013 15.9 0.0 4.0 4 0 0 4 4 4 1 HEAT-like repeat V-ATPase_H_C PF11698.3 ESL06202.1 - 0.03 14.2 2.3 25 4.8 0.0 4.0 3 0 0 3 3 3 0 V-ATPase subunit H UQ_con PF00179.21 ESL06203.1 - 6.6e-23 80.6 0.0 1.5e-22 79.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF834 PF05754.9 ESL06203.1 - 0.071 12.9 0.1 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF834) eIF2A PF08662.6 ESL06204.1 - 7.9e-08 32.2 0.0 3e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A adh_short PF00106.20 ESL06205.1 - 1.6e-07 31.4 0.2 2.4e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL06205.1 - 0.0071 16.0 0.0 0.016 14.8 0.0 1.5 2 0 0 2 2 2 1 KR domain Nfu_N PF08712.6 ESL06206.1 - 1.3e-23 82.3 0.0 2.4e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 ESL06206.1 - 1.5e-23 82.3 0.2 3e-23 81.3 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain Oxidored_FMN PF00724.15 ESL06207.1 - 4.2e-69 233.1 0.0 5e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Cation_efflux PF01545.16 ESL06208.1 - 1.6e-32 112.7 10.4 8.4e-32 110.3 7.2 1.9 1 1 0 1 1 1 1 Cation efflux family DUF705 PF05152.7 ESL06208.1 - 0.12 11.3 0.2 0.18 10.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) BAF1_ABF1 PF04684.8 ESL06208.1 - 0.27 10.0 6.8 0.47 9.2 4.7 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2946 PF11162.3 ESL06208.1 - 0.29 11.3 4.7 0.12 12.5 1.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) OsmC PF02566.14 ESL06209.1 - 2.1e-08 34.2 0.2 3.9e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 OsmC-like protein GLTSCR1 PF15249.1 ESL06209.1 - 0.097 12.7 1.5 7.9 6.6 1.3 2.5 2 1 0 2 2 2 0 Glioma tumor suppressor candidate region FliE PF02049.13 ESL06209.1 - 0.21 11.6 1.7 0.8 9.7 0.7 2.4 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE zf-Tim10_DDP PF02953.10 ESL06212.1 - 9.4e-06 24.8 1.6 1.3e-05 24.4 1.1 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger CENP-F_leu_zip PF10473.4 ESL06213.1 - 0.002 18.0 21.8 0.0021 17.8 1.8 4.0 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.15 ESL06213.1 - 0.002 17.2 16.3 0.002 17.2 11.3 1.5 1 1 0 1 1 1 1 Tropomyosin Lectin_N PF03954.9 ESL06213.1 - 0.0073 15.7 8.5 0.029 13.7 0.9 3.2 1 1 1 2 2 2 1 Hepatic lectin, N-terminal domain Laminin_II PF06009.7 ESL06213.1 - 0.0077 15.9 10.5 2.9 7.6 0.0 3.7 1 1 3 4 4 4 1 Laminin Domain II Baculo_PEP_C PF04513.7 ESL06213.1 - 0.0093 15.7 8.8 1.3 8.8 0.0 3.1 2 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.8 ESL06213.1 - 0.017 14.2 6.9 0.77 8.7 0.1 2.5 2 1 1 3 3 3 0 TMPIT-like protein DUF1664 PF07889.7 ESL06213.1 - 0.036 13.8 10.2 1.3 8.8 1.5 3.5 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) DUF2365 PF10157.4 ESL06213.1 - 0.063 13.1 2.0 0.3 10.9 0.2 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2365) NumbF PF06311.7 ESL06213.1 - 0.068 13.2 1.4 0.46 10.6 0.1 2.5 2 0 0 2 2 2 0 NUMB domain GCR PF02155.10 ESL06213.1 - 0.088 11.5 0.1 0.19 10.4 0.1 1.5 1 0 0 1 1 1 0 Glucocorticoid receptor GAS PF13851.1 ESL06213.1 - 0.16 11.1 13.8 0.3 10.2 2.5 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding THP2 PF09432.5 ESL06213.1 - 0.17 11.7 4.3 7.8 6.3 0.7 2.7 2 1 0 2 2 2 0 Tho complex subunit THP2 AcylCoA_dehyd_C PF12186.3 ESL06213.1 - 0.18 11.6 3.5 0.18 11.6 0.2 2.6 2 2 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal Spc7 PF08317.6 ESL06213.1 - 0.22 10.1 16.4 0.33 9.5 0.5 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Bacillus_HBL PF05791.6 ESL06213.1 - 0.35 10.2 8.5 1.3 8.3 1.4 2.4 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Fib_alpha PF08702.5 ESL06213.1 - 0.56 10.3 10.2 16 5.5 2.3 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.2 ESL06213.1 - 0.74 9.6 23.9 0.95 9.3 6.1 3.2 2 1 1 3 3 3 0 Tropomyosin like DUF4618 PF15397.1 ESL06213.1 - 1.1 8.5 14.8 0.62 9.3 5.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) PspB PF06667.7 ESL06213.1 - 1.1 9.2 9.8 1.9 8.4 0.7 3.4 2 1 1 3 3 3 0 Phage shock protein B NPV_P10 PF05531.7 ESL06213.1 - 1.3 9.3 10.8 23 5.3 0.1 4.2 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein PMC2NT PF08066.7 ESL06213.1 - 1.8 8.9 5.9 1.1 9.5 1.8 2.2 2 0 0 2 2 2 0 PMC2NT (NUC016) domain AAA_13 PF13166.1 ESL06213.1 - 2.5 6.4 10.7 4.2 5.7 4.5 2.0 1 1 1 2 2 2 0 AAA domain TetR PF13972.1 ESL06213.1 - 2.6 7.4 10.4 0.76 9.2 0.7 3.1 3 1 0 3 3 3 0 Bacterial transcriptional repressor TBPIP PF07106.8 ESL06213.1 - 2.6 7.5 17.0 2.2 7.8 4.9 2.9 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIVA PF05103.8 ESL06213.1 - 3.1 7.8 17.2 12 5.9 2.2 3.8 2 1 1 3 3 3 0 DivIVA protein Hemerythrin PF01814.18 ESL06213.1 - 3.2 7.9 13.8 11 6.1 1.0 4.0 1 1 2 3 3 3 0 Hemerythrin HHE cation binding domain ApoLp-III PF07464.6 ESL06213.1 - 4.1 7.4 10.0 12 5.9 3.5 3.1 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF2802 PF10975.3 ESL06213.1 - 4.1 7.2 15.0 2.5 7.9 0.1 4.8 2 2 3 5 5 5 0 Protein of unknown function (DUF2802) GP41 PF00517.12 ESL06213.1 - 4.4 6.8 7.5 7.3 6.0 0.5 2.9 2 1 0 3 3 3 0 Retroviral envelope protein TLD PF07534.11 ESL06214.1 - 5.2e-13 49.1 0.0 5.4e-07 29.6 0.0 2.9 3 1 0 3 3 3 2 TLD DNA_pol_A PF00476.15 ESL06215.1 - 1.1e-26 93.4 0.0 1.9e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A RNase_T PF00929.19 ESL06215.1 - 1.2e-17 64.7 0.0 6.6e-17 62.2 0.0 2.2 2 0 0 2 2 2 1 Exonuclease NAD_binding_3 PF03447.11 ESL06215.1 - 0.0085 16.4 0.0 0.052 13.9 0.0 2.4 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain GSHPx PF00255.14 ESL06216.1 - 0.0033 16.7 0.0 0.005 16.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase Lipoprotein_15 PF03640.10 ESL06216.1 - 0.063 12.7 0.0 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 Secreted repeat of unknown function DUF1801 PF08818.6 ESL06216.1 - 0.13 12.3 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DU1801) ParcG PF10274.4 ESL06217.1 - 1.1e-77 260.1 0.1 1.3e-77 259.8 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein Rootletin PF15035.1 ESL06218.1 - 0.0003 20.8 2.0 0.00055 19.9 1.4 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion ERM PF00769.14 ESL06218.1 - 2.6 7.5 11.5 5.1 6.5 5.2 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family XRN_N PF03159.13 ESL06219.1 - 0.0011 18.4 0.0 0.01 15.2 0.0 2.3 1 1 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Pkinase PF00069.20 ESL06220.1 - 2.9e-60 203.6 0.0 3.7e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06220.1 - 2e-41 141.7 0.0 2.9e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06220.1 - 3.9e-09 35.9 0.0 1.4e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PH PF00169.24 ESL06220.1 - 0.00088 19.4 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 PH domain DUF1636 PF07845.6 ESL06220.1 - 0.042 14.0 0.1 0.1 12.8 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1636) PH_9 PF15410.1 ESL06220.1 - 0.049 13.7 0.8 0.72 10.0 0.5 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain Pox_ser-thr_kin PF05445.6 ESL06220.1 - 0.053 12.3 0.1 0.081 11.7 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Atg14 PF10186.4 ESL06221.1 - 0.0087 15.0 0.0 0.024 13.6 0.0 1.6 1 1 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 C2 PF00168.25 ESL06221.1 - 0.01 15.6 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 C2 domain DUF1989 PF09347.5 ESL06221.1 - 0.13 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) LRR_6 PF13516.1 ESL06223.1 - 3e-23 79.2 22.9 0.99 9.6 0.0 14.6 14 1 1 15 15 15 9 Leucine Rich repeat LRR_4 PF12799.2 ESL06223.1 - 1.8e-20 72.0 18.9 0.00012 21.6 0.0 10.5 7 3 5 12 12 12 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL06223.1 - 2.9e-14 50.8 21.0 6.8 7.1 0.1 14.2 15 0 0 15 15 15 3 Leucine Rich Repeat LRR_7 PF13504.1 ESL06223.1 - 5.2e-07 28.8 28.1 5.5 7.6 0.6 13.7 16 0 0 16 16 16 1 Leucine rich repeat LRR_8 PF13855.1 ESL06223.1 - 3e-05 23.6 32.1 0.014 15.1 2.1 9.8 8 3 2 11 11 11 4 Leucine rich repeat UPF0154 PF03672.8 ESL06223.1 - 0.039 13.5 0.0 6.7 6.4 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) YqfD PF06898.6 ESL06223.1 - 0.33 9.6 0.0 0.51 8.9 0.0 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD zf-CCHC_4 PF14392.1 ESL06224.1 - 0.075 12.7 0.7 0.16 11.6 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF4153 PF13687.1 ESL06225.1 - 0.001 18.6 0.5 0.1 12.1 0.4 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4153) Amnionless PF14828.1 ESL06225.1 - 0.18 10.2 5.7 1.6 7.1 1.0 2.0 1 1 1 2 2 2 0 Amnionless zf-DHHC PF01529.15 ESL06225.1 - 0.42 9.9 2.1 0.8 9.0 1.4 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase Nol1_Nop2_Fmu PF01189.12 ESL06226.1 - 3.1e-16 59.5 0.1 1.6e-06 27.7 0.0 4.0 3 1 0 3 3 3 3 NOL1/NOP2/sun family PCMT PF01135.14 ESL06226.1 - 0.0022 17.5 0.0 0.015 14.8 0.0 2.0 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 ESL06226.1 - 0.021 14.4 0.0 0.27 10.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 ESL06226.1 - 0.13 12.2 0.0 0.46 10.4 0.0 1.9 1 1 0 1 1 1 0 FtsJ-like methyltransferase Kinesin PF00225.18 ESL06227.1 - 2.1e-92 309.3 1.4 2.4e-92 309.1 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain KH_1 PF00013.24 ESL06228.1 - 0.0022 17.6 0.1 0.005 16.4 0.1 1.6 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ESL06228.1 - 0.013 15.1 0.0 0.031 13.9 0.0 1.6 1 0 0 1 1 1 0 KH domain DUF3586 PF12131.3 ESL06229.1 - 5.3e-24 84.0 8.4 5.3e-24 84.0 5.8 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3586) Peptidase_C1 PF00112.18 ESL06229.1 - 4.2e-22 79.1 1.4 7.5e-22 78.2 1.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 ESL06229.1 - 0.00057 18.5 0.1 0.00072 18.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase C1-like family PPR_3 PF13812.1 ESL06230.1 - 5e-19 66.9 5.3 5.4e-05 23.1 0.0 7.3 7 0 0 7 7 7 3 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESL06230.1 - 6e-18 64.5 3.9 4.3e-07 29.7 0.0 6.1 6 1 1 7 7 7 3 PPR repeat family PPR PF01535.15 ESL06230.1 - 2.7e-07 30.1 6.0 0.11 12.5 0.1 5.9 6 0 0 6 6 6 2 PPR repeat PPR_1 PF12854.2 ESL06230.1 - 2.5e-06 26.8 0.1 0.076 12.4 0.0 4.4 4 1 0 4 4 4 2 PPR repeat TPR_12 PF13424.1 ESL06231.1 - 2.1e-09 37.1 10.4 5.5e-05 23.0 1.8 3.6 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06231.1 - 1.9e-08 33.8 13.0 0.0001 21.8 0.7 3.6 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.1 ESL06231.1 - 1.6e-05 25.4 7.1 0.00021 21.8 0.1 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06231.1 - 3.7e-05 23.1 0.5 0.4 10.6 0.0 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06231.1 - 7.9e-05 22.2 12.6 1.7 8.7 0.0 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06231.1 - 0.00018 20.9 15.9 0.063 12.9 0.0 4.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06231.1 - 0.00083 18.9 5.7 0.97 9.3 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06231.1 - 0.0011 19.2 7.0 0.72 10.4 0.1 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06231.1 - 0.0059 17.1 1.9 7.9 7.4 0.0 4.8 3 1 3 6 6 4 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL06231.1 - 0.078 13.1 0.1 0.078 13.1 0.1 3.1 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESL06231.1 - 0.26 11.5 5.2 75 3.9 0.2 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat LRR_4 PF12799.2 ESL06234.1 - 4.6e-15 54.8 2.3 0.01 15.4 0.0 5.7 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL06234.1 - 5.7e-08 32.3 10.5 0.0014 18.3 0.7 4.8 3 2 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 ESL06234.1 - 3.5e-06 26.2 8.4 0.15 12.1 0.1 5.4 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.1 ESL06234.1 - 0.00074 19.3 5.6 2 8.7 0.1 4.7 4 1 0 4 4 4 2 Leucine Rich repeat LRR_7 PF13504.1 ESL06234.1 - 0.016 15.2 8.8 11 6.7 0.0 5.1 5 0 0 5 5 5 0 Leucine rich repeat PI3_PI4_kinase PF00454.22 ESL06235.1 - 1.2e-45 155.8 0.2 4e-45 154.1 0.1 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESL06235.1 - 4.3e-28 98.3 0.6 1.5e-27 96.5 0.4 2.0 1 1 0 1 1 1 1 FAT domain Rapamycin_bind PF08771.6 ESL06235.1 - 4.5e-21 74.8 0.3 2.4e-20 72.4 0.2 2.4 1 0 0 1 1 1 1 Rapamycin binding domain DUF3385 PF11865.3 ESL06235.1 - 1.8e-19 70.2 0.2 1.8e-19 70.2 0.2 3.7 6 0 0 6 6 6 1 Domain of unknown function (DUF3385) FATC PF02260.15 ESL06235.1 - 3.6e-15 55.0 0.1 8.9e-15 53.8 0.1 1.7 1 0 0 1 1 1 1 FATC domain PDZ PF00595.19 ESL06235.1 - 3.8e-06 27.0 0.1 8e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) HEAT_2 PF13646.1 ESL06235.1 - 0.00034 20.8 9.9 0.017 15.3 0.8 4.6 4 0 0 4 4 4 2 HEAT repeats TPR_11 PF13414.1 ESL06235.1 - 0.00044 19.8 0.0 0.0063 16.1 0.0 3.0 3 0 0 3 3 3 1 TPR repeat HEAT PF02985.17 ESL06235.1 - 0.0014 18.5 2.9 0.15 12.1 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat PDZ_2 PF13180.1 ESL06235.1 - 0.0016 18.3 0.1 0.0036 17.1 0.1 1.5 1 0 0 1 1 1 1 PDZ domain TPR_17 PF13431.1 ESL06235.1 - 0.054 13.7 0.0 2.7 8.4 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Tricorn_PDZ PF14685.1 ESL06235.1 - 0.092 12.5 0.0 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 Tricorn protease PDZ domain HAS-barrel PF09378.5 ESL06235.1 - 0.51 10.2 1.1 28 4.6 0.0 3.1 3 0 0 3 3 3 0 HAS barrel domain Pkinase PF00069.20 ESL06236.1 - 9.6e-56 188.7 0.0 1.6e-55 188.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06236.1 - 3.1e-25 88.7 0.0 2.5e-22 79.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESL06236.1 - 0.00014 21.6 0.2 0.0032 17.2 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESL06236.1 - 0.00085 18.7 1.6 0.002 17.4 1.1 1.5 1 1 1 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESL06236.1 - 0.11 11.8 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 ESL06236.1 - 0.13 11.2 0.0 0.29 10.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HHH_5 PF14520.1 ESL06237.1 - 0.00043 20.3 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 ESL06237.1 - 0.0078 16.0 0.0 0.022 14.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.18 ESL06237.1 - 0.082 12.6 0.1 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif Bystin PF05291.6 ESL06239.1 - 7.5e-108 360.0 0.1 1.1e-107 359.4 0.1 1.1 1 0 0 1 1 1 1 Bystin DUF3299 PF11736.3 ESL06239.1 - 0.074 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) LRR_4 PF12799.2 ESL06240.1 - 1.1e-07 31.2 0.1 0.51 10.0 0.1 5.0 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL06240.1 - 8.8e-06 25.3 1.9 0.041 13.6 0.2 4.2 3 2 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESL06240.1 - 0.0002 20.9 0.5 36 4.9 0.0 6.1 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.1 ESL06240.1 - 0.00025 20.7 0.2 21 5.5 0.0 5.9 6 0 0 6 6 6 1 Leucine Rich repeat LRR_7 PF13504.1 ESL06240.1 - 0.24 11.7 3.1 96 3.8 0.0 5.4 6 0 0 6 6 6 0 Leucine rich repeat DUF1664 PF07889.7 ESL06240.1 - 1.3 8.8 4.6 15 5.4 3.2 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) PHD PF00628.24 ESL06241.1 - 6.1e-07 29.0 9.0 1.5e-06 27.7 6.2 1.7 1 0 0 1 1 1 1 PHD-finger Acetyltransf_1 PF00583.19 ESL06241.1 - 3.5e-05 23.7 0.1 0.00067 19.6 0.0 2.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESL06241.1 - 0.00034 20.7 0.3 0.007 16.4 0.2 2.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESL06241.1 - 0.0026 17.8 0.0 0.0071 16.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL06241.1 - 0.049 13.4 0.7 3.5 7.5 0.1 3.0 2 1 1 3 3 3 0 Acetyltransferase (GNAT) domain Dpy-30 PF05186.8 ESL06243.1 - 1.3e-05 24.5 0.0 2.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Dpy-30 motif MR_MLE PF01188.16 ESL06243.1 - 0.1 13.1 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain TerB PF05099.8 ESL06244.1 - 0.078 12.7 0.1 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TerB SNAP PF14938.1 ESL06245.1 - 1e-23 83.9 9.4 1.5e-23 83.4 6.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP GreA_GreB_N PF03449.10 ESL06245.1 - 0.022 14.8 0.1 0.051 13.6 0.0 1.6 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Tachystatin_B PF11478.3 ESL06245.1 - 0.065 12.9 1.2 0.13 11.9 0.1 2.1 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B TPR_12 PF13424.1 ESL06245.1 - 0.12 12.3 2.2 0.88 9.5 1.4 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06245.1 - 2.5 7.8 6.1 1.2 8.8 0.7 3.0 3 1 0 3 3 3 0 TPR repeat PPR_3 PF13812.1 ESL06246.1 - 4.1e-06 26.6 1.4 0.17 12.2 0.0 5.7 5 1 1 6 6 6 2 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESL06246.1 - 0.0022 17.9 0.1 4.1 7.4 0.1 4.6 4 1 1 5 5 5 2 PPR repeat family PPR PF01535.15 ESL06246.1 - 0.0048 16.7 0.0 2.2 8.4 0.0 4.1 4 0 0 4 4 4 1 PPR repeat Patatin PF01734.17 ESL06246.1 - 0.087 12.7 0.0 7.2 6.4 0.0 2.5 3 0 0 3 3 3 0 Patatin-like phospholipase TPR_10 PF13374.1 ESL06246.1 - 0.19 11.6 4.3 3.4 7.7 0.9 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat RabGAP-TBC PF00566.13 ESL06247.1 - 1.7e-52 178.0 0.5 2.2e-52 177.6 0.3 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3051 PF11252.3 ESL06247.1 - 0.068 12.6 0.1 1.2 8.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3051) DUF2453 PF10507.4 ESL06248.1 - 6.2e-45 151.5 7.6 9.2e-45 151.0 5.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2453) EF-hand_7 PF13499.1 ESL06248.1 - 1.5e-07 31.4 0.4 0.022 14.9 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL06248.1 - 1.5e-05 23.9 0.1 0.2 11.0 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 ESL06248.1 - 0.00018 21.0 0.8 3.8 7.6 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain DUF2336 PF10098.4 ESL06248.1 - 0.044 13.0 0.1 0.22 10.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2336) SGT1 PF07093.6 ESL06248.1 - 0.16 10.2 0.1 0.21 9.9 0.1 1.1 1 0 0 1 1 1 0 SGT1 protein Enkurin PF13864.1 ESL06249.1 - 4e-23 81.4 2.7 5.8e-23 80.9 1.8 1.2 1 0 0 1 1 1 1 Calmodulin-binding DUF4482 PF14818.1 ESL06249.1 - 0.094 13.3 5.1 0.16 12.6 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) PilJ PF13675.1 ESL06249.1 - 0.11 12.8 3.6 0.22 11.8 2.4 1.5 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term AMP-binding PF00501.23 ESL06250.1 - 4.5e-43 147.2 0.1 5.3e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme GOLGA2L5 PF15070.1 ESL06251.1 - 0.007 14.9 1.7 0.011 14.2 1.2 1.2 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 NTR2 PF15458.1 ESL06251.1 - 0.0093 15.2 0.5 0.016 14.4 0.3 1.4 1 0 0 1 1 1 1 Nineteen complex-related protein 2 Spc7 PF08317.6 ESL06251.1 - 0.026 13.1 0.2 0.043 12.4 0.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.6 ESL06251.1 - 0.029 14.2 4.4 0.039 13.7 2.3 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) FH2 PF02181.18 ESL06251.1 - 0.044 12.6 0.6 0.064 12.1 0.4 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain APG6 PF04111.7 ESL06251.1 - 0.056 12.4 1.8 0.084 11.9 1.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF812 PF05667.6 ESL06251.1 - 0.083 11.3 3.3 1.1 7.6 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) CENP-Q PF13094.1 ESL06251.1 - 1.9 8.4 7.5 0.21 11.6 2.2 1.8 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Mnd1 PF03962.10 ESL06251.1 - 3 7.4 5.4 0.53 9.9 1.0 1.8 2 0 0 2 2 2 0 Mnd1 family HSP70 PF00012.15 ESL06252.1 - 6e-183 609.0 2.4 6.7e-183 608.8 1.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL06252.1 - 1.1e-14 53.8 0.1 2.4e-13 49.3 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 ESL06252.1 - 0.0023 17.7 0.3 0.26 11.1 0.2 3.2 1 1 0 1 1 1 1 Cell division protein FtsA DDR PF08841.5 ESL06252.1 - 0.016 14.0 0.3 1.4 7.6 0.0 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.6 ESL06252.1 - 0.026 13.4 0.1 0.04 12.8 0.0 1.4 1 1 0 1 1 1 0 StbA protein FGGY_C PF02782.11 ESL06252.1 - 0.029 13.9 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain SRI PF08236.6 ESL06252.1 - 0.034 14.0 0.2 0.11 12.4 0.2 1.8 1 1 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Asp_decarbox PF02261.11 ESL06252.1 - 0.035 13.6 0.1 0.065 12.8 0.1 1.5 1 0 0 1 1 1 0 Aspartate decarboxylase Hydantoinase_A PF01968.13 ESL06252.1 - 0.048 12.7 0.1 4.3 6.3 0.0 2.5 1 1 1 2 2 2 0 Hydantoinase/oxoprolinase Pro_CA PF00484.14 ESL06254.1 - 6 6.8 8.3 1.3 9.0 0.2 2.7 2 0 0 2 2 2 0 Carbonic anhydrase WD40 PF00400.27 ESL06256.1 - 2.5e-12 46.1 6.8 0.0012 18.5 0.3 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat Lgl_C PF08596.5 ESL06256.1 - 0.19 10.1 0.0 0.9 7.9 0.0 1.9 2 0 0 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal Pescadillo_N PF06732.6 ESL06257.1 - 6.4e-94 314.3 5.5 6.4e-94 314.3 3.8 1.8 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT PF00533.21 ESL06257.1 - 6.4e-10 39.0 0.0 2.2e-09 37.2 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain DUF3479 PF11965.3 ESL06257.1 - 0.01 15.6 4.4 2.7 7.7 2.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3479) SNF2_N PF00176.18 ESL06258.1 - 9.1e-60 201.9 0.0 1.5e-59 201.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL06258.1 - 2.1e-15 56.3 0.0 4.9e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL06258.1 - 3e-11 43.0 0.0 5.8e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ATP-synt_ab PF00006.20 ESL06259.1 - 5.3e-109 362.7 0.0 9.1e-109 361.9 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL06259.1 - 3.5e-25 88.6 0.1 5.6e-25 88.0 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESL06259.1 - 1e-13 51.2 1.6 1e-13 51.2 1.1 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_16 PF13191.1 ESL06259.1 - 0.12 12.3 0.0 0.64 9.9 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 ESL06259.1 - 0.13 12.2 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain LRR_4 PF12799.2 ESL06260.1 - 6.2e-16 57.6 5.9 0.00039 19.9 2.6 4.4 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL06260.1 - 1.7e-15 56.4 6.9 1.3e-06 28.0 3.6 3.5 3 0 0 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESL06260.1 - 1.4e-08 33.5 10.3 1.2 9.4 0.0 6.8 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 ESL06260.1 - 6.9e-06 25.4 12.0 1.3 9.5 0.1 6.3 6 0 0 6 6 6 2 Leucine rich repeat LRR_6 PF13516.1 ESL06260.1 - 4.6e-05 23.0 12.1 0.78 10.0 0.4 5.1 4 1 1 5 5 5 3 Leucine Rich repeat LRR_9 PF14580.1 ESL06260.1 - 0.014 14.9 1.0 9.1 5.7 0.2 3.3 3 1 0 3 3 3 0 Leucine-rich repeat DUF2580 PF10824.3 ESL06260.1 - 0.041 14.2 1.8 0.11 12.7 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2580) UvrD-helicase PF00580.16 ESL06261.1 - 1.7e-42 145.8 0.0 3.8e-40 138.1 0.0 2.2 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 ESL06261.1 - 1.5e-26 93.7 0.0 5.7e-14 52.3 0.0 2.7 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 ESL06261.1 - 8.9e-11 41.3 1.0 9.4e-10 38.1 0.1 2.7 2 0 0 2 2 2 1 Part of AAA domain UvrD_C_2 PF13538.1 ESL06261.1 - 2e-10 40.7 0.0 7.9e-10 38.8 0.0 2.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 ESL06261.1 - 7e-08 32.2 0.2 0.0018 17.8 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 ESL06261.1 - 2.8e-05 24.2 0.1 0.39 10.8 0.0 3.8 4 0 0 4 4 4 2 AAA domain AAA_12 PF13087.1 ESL06261.1 - 0.00048 19.5 0.0 0.021 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain PhoH PF02562.11 ESL06261.1 - 0.0046 16.2 0.1 0.17 11.0 0.0 2.8 2 1 0 2 2 2 1 PhoH-like protein AAA_16 PF13191.1 ESL06261.1 - 0.048 13.6 7.0 0.017 15.0 1.1 2.9 3 1 0 3 3 3 0 AAA ATPase domain ResIII PF04851.10 ESL06261.1 - 0.11 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Nop14 PF04147.7 ESL06262.1 - 0.54 8.1 7.4 0.71 7.7 5.1 1.1 1 0 0 1 1 1 0 Nop14-like family SNARE PF05739.14 ESL06263.1 - 1.3e-18 66.4 1.0 1.3e-18 66.4 0.7 2.6 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESL06263.1 - 0.0011 19.1 6.6 0.077 13.1 1.2 2.4 2 0 0 2 2 2 2 Syntaxin MCPsignal PF00015.16 ESL06263.1 - 0.1 12.1 5.8 0.1 12.0 0.9 2.6 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SlyX PF04102.7 ESL06263.1 - 3 8.2 7.9 1.2 9.6 0.1 3.6 2 2 2 4 4 4 0 SlyX ACPS PF01648.15 ESL06265.1 - 0.038 13.7 0.0 0.099 12.4 0.0 1.7 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase superfamily SPRY PF00622.23 ESL06266.1 - 2.2e-05 24.5 0.0 4.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 SPRY domain UPF0016 PF01169.14 ESL06267.1 - 3.4e-43 145.6 23.4 8.4e-23 80.3 4.9 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Abhydrolase_9_N PF15420.1 ESL06267.1 - 0.42 10.3 8.1 0.28 10.9 0.2 2.3 1 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus IncA PF04156.9 ESL06268.1 - 0.039 13.5 8.4 0.051 13.1 5.4 1.4 1 1 0 1 1 1 0 IncA protein Mnd1 PF03962.10 ESL06268.1 - 0.04 13.5 3.4 0.071 12.7 2.3 1.3 1 0 0 1 1 1 0 Mnd1 family KH_1 PF00013.24 ESL06268.1 - 0.067 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 KH domain Glyco_hydro_2_C PF02836.12 ESL06268.1 - 0.1 11.4 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain DUF793 PF05633.6 ESL06268.1 - 0.22 10.2 4.0 0.075 11.7 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF793) Peripla_BP_6 PF13458.1 ESL06269.1 - 6.2e-11 42.2 1.3 8.6e-11 41.7 0.9 1.2 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.23 ESL06269.1 - 0.064 12.0 0.0 0.098 11.4 0.0 1.3 1 0 0 1 1 1 0 Receptor family ligand binding region Thioredoxin_7 PF13899.1 ESL06270.1 - 0.0012 18.7 0.0 0.0034 17.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like zf-B_box PF00643.19 ESL06271.1 - 2.4e-08 33.7 1.5 2.4e-08 33.7 1.0 1.8 2 0 0 2 2 2 1 B-box zinc finger Myosin_tail_1 PF01576.14 ESL06271.1 - 0.032 11.9 0.1 0.047 11.4 0.1 1.1 1 0 0 1 1 1 0 Myosin tail DUF4457 PF14652.1 ESL06272.1 - 7e-30 104.1 0.0 7.8e-11 41.5 0.0 5.1 5 0 0 5 5 5 5 Domain of unknown function (DUF4457) zf-C3HC4_2 PF13923.1 ESL06273.1 - 2.3e-11 43.5 9.3 2.3e-11 43.5 6.4 3.8 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL06273.1 - 3.9e-09 36.0 7.5 3.9e-09 36.0 5.2 4.3 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL06273.1 - 9.1e-08 31.8 8.6 9.1e-08 31.8 5.9 4.6 5 0 0 5 5 5 1 Ring finger domain zf-RING_5 PF14634.1 ESL06273.1 - 6.8e-07 28.9 8.6 6.8e-07 28.9 5.9 3.9 4 1 0 4 4 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL06273.1 - 3.4e-06 26.6 6.4 3.4e-06 26.6 4.4 4.1 5 0 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESL06273.1 - 2.4e-05 23.9 2.4 0.00014 21.5 1.7 2.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESL06273.1 - 7.3e-05 22.5 9.2 7.3e-05 22.5 6.4 3.3 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 ESL06273.1 - 0.00064 19.4 5.4 0.00064 19.4 3.7 2.5 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 ESL06273.1 - 0.011 15.8 2.1 0.011 15.8 1.4 3.5 2 1 1 3 3 2 0 RING-H2 zinc finger U-box PF04564.10 ESL06273.1 - 0.069 13.1 0.0 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 U-box domain Rad50_zn_hook PF04423.9 ESL06273.1 - 0.19 11.2 4.6 22 4.6 0.1 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif Peptidase_C1 PF00112.18 ESL06275.1 - 5.2e-67 225.9 4.2 7.6e-67 225.3 2.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.3 ESL06275.1 - 2.5e-23 81.8 8.4 2.5e-23 81.8 5.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.7 ESL06275.1 - 2.4e-10 40.5 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 ESL06275.1 - 0.00012 20.8 0.4 0.0024 16.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase C1-like family Trypsin_2 PF13365.1 ESL06276.1 - 0.0011 18.8 1.1 0.0021 18.0 0.8 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.8 ESL06276.1 - 0.0015 17.5 0.2 0.0024 16.8 0.0 1.4 2 0 0 2 2 2 1 Equine arteritis virus serine endopeptidase S32 Peptidase_S29 PF02907.10 ESL06276.1 - 0.024 14.1 0.2 0.039 13.4 0.1 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Ribosomal_L18e PF00828.14 ESL06278.1 - 6.7e-36 123.5 0.5 7.9e-36 123.2 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Cytochrom_C PF00034.16 ESL06279.1 - 2.1e-10 41.2 0.0 2.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 ESL06279.1 - 0.00018 21.6 2.3 0.00088 19.3 1.6 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III zf-AN1 PF01428.11 ESL06280.1 - 1.2e-07 31.4 4.2 1.7e-07 30.9 2.9 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger zf-C2HC5 PF06221.8 ESL06280.1 - 0.015 15.0 3.1 0.022 14.4 2.1 1.3 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Fumerase PF05681.9 ESL06281.1 - 4.7e-86 288.2 0.0 6.4e-86 287.7 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.7 ESL06281.1 - 1.2e-78 263.0 0.0 1.9e-78 262.3 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus Pkinase PF00069.20 ESL06282.1 - 2.8e-76 256.1 0.0 3.8e-76 255.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06282.1 - 5.9e-38 130.4 0.0 5.9e-37 127.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06282.1 - 0.00084 18.3 0.0 0.0027 16.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL06282.1 - 0.022 14.4 0.3 0.38 10.4 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESL06282.1 - 0.18 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Endonuclease_5 PF04493.9 ESL06283.1 - 5.5e-49 166.3 0.0 8.1e-49 165.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease V UvrC_HhH_N PF08459.6 ESL06283.1 - 0.0066 15.9 0.0 0.016 14.7 0.0 1.6 1 1 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal Ribosomal_L14 PF00238.14 ESL06284.1 - 1.4e-36 124.8 0.0 1.6e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e 3HCDH_N PF02737.13 ESL06285.1 - 2.2e-43 147.9 0.7 3.2e-43 147.4 0.0 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH PF00378.15 ESL06285.1 - 4.5e-42 143.8 0.0 1.1e-41 142.6 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family 3HCDH PF00725.17 ESL06285.1 - 1.1e-24 86.6 0.0 3.4e-13 49.7 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_3 PF03447.11 ESL06285.1 - 0.00041 20.7 0.2 0.0012 19.2 0.2 1.8 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain TrkA_N PF02254.13 ESL06285.1 - 0.0012 18.7 0.1 0.0032 17.4 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain Saccharop_dh PF03435.13 ESL06285.1 - 0.041 12.8 0.1 0.068 12.1 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_2 PF03446.10 ESL06285.1 - 0.058 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.9 ESL06285.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CLP_protease PF00574.18 ESL06285.1 - 0.12 11.9 1.5 4.7 6.8 0.0 3.0 3 0 0 3 3 3 0 Clp protease NAD_Gly3P_dh_N PF01210.18 ESL06285.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AAA_14 PF13173.1 ESL06288.1 - 0.02 14.7 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL06288.1 - 0.021 14.2 0.1 0.042 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.20 ESL06289.1 - 5.6e-42 143.6 0.0 6.3e-42 143.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06289.1 - 5.5e-13 48.5 0.0 7.8e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06289.1 - 2.1e-05 23.6 0.0 2.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Kinase-like HhH-GPD PF00730.20 ESL06290.1 - 3.3e-17 62.7 0.0 6.1e-17 61.8 0.0 1.5 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 ESL06290.1 - 2.8e-08 33.0 0.0 6.8e-08 31.7 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.1 ESL06290.1 - 0.0034 17.5 0.1 0.27 11.4 0.0 2.1 1 1 1 2 2 2 2 Helix-hairpin-helix domain DUF763 PF05559.6 ESL06290.1 - 0.0069 15.3 0.1 2.5 6.9 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF763) EndIII_4Fe-2S PF10576.4 ESL06290.1 - 0.021 14.9 8.8 0.021 14.9 6.1 1.8 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III Synaptobrevin PF00957.16 ESL06291.1 - 6.2e-18 64.1 0.3 9.9e-18 63.5 0.2 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 ESL06291.1 - 9.1e-07 28.3 0.0 1.4e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Bromo_coat PF01318.13 ESL06291.1 - 0.017 14.8 0.1 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Bromovirus coat protein HpcH_HpaI PF03328.9 ESL06293.1 - 1.6e-06 27.1 0.0 6.3e-06 25.2 0.0 2.2 2 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 ESL06293.1 - 0.00019 20.3 0.0 0.00053 18.8 0.0 1.7 2 0 0 2 2 2 1 C-C_Bond_Lyase of the TIM-Barrel fold Kinesin PF00225.18 ESL06294.1 - 1.3e-85 287.0 0.0 2.9e-85 285.9 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain ResIII PF04851.10 ESL06294.1 - 0.8 9.5 6.7 2.5 7.8 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Ribosomal_S4e PF00900.15 ESL06295.1 - 1e-24 85.9 0.4 2.1e-24 85.0 0.3 1.5 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.7 ESL06295.1 - 2e-18 65.9 2.6 6.8e-18 64.2 1.8 2.0 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 ESL06295.1 - 8e-11 41.1 0.0 1.7e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 ESL06295.1 - 5.6e-06 25.8 0.5 2.2e-05 23.9 0.1 2.2 2 0 0 2 2 2 1 KOW motif Acetyltransf_13 PF13880.1 ESL06296.1 - 1.2e-24 85.8 0.0 1.5e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase DUF3681 PF12442.3 ESL06296.1 - 0.00067 19.8 0.4 0.0013 18.9 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3681) Acetyltransf_1 PF00583.19 ESL06296.1 - 0.00095 19.1 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESL06296.1 - 0.032 14.3 0.0 0.032 14.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESL06296.1 - 0.044 13.9 0.0 0.053 13.6 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL06296.1 - 0.14 11.9 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein zf-UBR PF02207.15 ESL06297.1 - 4.6e-15 55.0 12.8 9.4e-15 54.0 8.9 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) N1221 PF07923.8 ESL06297.1 - 0.12 11.1 0.1 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 N1221-like protein LSM PF01423.17 ESL06298.1 - 1.6e-11 43.5 0.0 2.1e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF3247 PF11607.3 ESL06298.1 - 0.042 14.0 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) TPR_19 PF14559.1 ESL06299.1 - 6.5e-15 55.2 31.4 9.4e-05 22.6 0.0 8.6 8 1 0 9 9 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06299.1 - 2.2e-13 50.4 26.3 0.18 12.5 0.9 9.0 8 2 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06299.1 - 1.5e-10 40.5 19.9 0.0053 16.3 0.0 6.9 6 2 2 8 8 7 5 TPR repeat TPR_2 PF07719.12 ESL06299.1 - 6.3e-09 35.0 15.7 0.29 11.1 0.0 8.8 9 0 0 9 9 8 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL06299.1 - 1.4e-08 34.7 15.7 0.24 11.5 0.0 6.8 5 2 2 8 8 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESL06299.1 - 2.2e-08 33.9 37.0 0.0065 17.0 0.5 10.5 7 4 4 11 11 11 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06299.1 - 3.3e-05 23.2 9.0 4 7.2 0.2 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat NARP1 PF12569.3 ESL06299.1 - 5.6e-05 22.0 0.4 0.00085 18.1 0.0 2.7 4 0 0 4 4 4 1 NMDA receptor-regulated protein 1 TPR_17 PF13431.1 ESL06299.1 - 0.00016 21.5 6.3 11 6.4 0.0 6.5 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06299.1 - 0.00044 20.5 25.2 1.8 9.2 0.5 9.1 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06299.1 - 0.00047 20.0 28.7 0.14 12.1 0.2 7.6 5 3 4 9 9 9 4 Tetratricopeptide repeat TPR_4 PF07721.9 ESL06299.1 - 0.0017 18.6 16.7 7.8 7.2 0.1 7.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06299.1 - 0.0017 17.9 9.1 8.3 6.4 0.1 6.9 9 0 0 9 9 7 0 Tetratricopeptide repeat SNAP PF14938.1 ESL06299.1 - 0.0075 15.4 0.3 4.2 6.4 0.0 3.4 3 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 ESL06299.1 - 0.018 14.8 14.6 3 7.8 0.3 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL06299.1 - 0.024 14.5 4.6 7.9 6.4 0.1 4.4 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.1 ESL06299.1 - 0.39 9.7 18.2 0.16 10.9 0.6 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat Apc5 PF12862.2 ESL06299.1 - 0.45 10.3 6.9 7.6 6.4 2.1 4.3 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 5 MIT PF04212.13 ESL06299.1 - 0.98 9.3 4.6 7.4 6.5 0.2 4.0 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESL06300.1 - 6.8e-10 38.4 1.1 1.3e-08 34.3 0.7 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESL06300.1 - 3.6e-08 32.7 1.1 0.00082 19.1 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06300.1 - 5.6e-08 32.6 1.0 0.0017 18.2 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06300.1 - 1.7e-07 30.5 0.3 0.00015 21.2 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06300.1 - 1e-06 28.0 0.2 0.0019 17.8 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06300.1 - 0.00079 19.8 0.2 0.86 10.4 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06300.1 - 0.00084 19.9 0.5 0.21 12.3 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat SET PF00856.23 ESL06300.1 - 0.0012 19.1 0.2 0.1 12.9 0.2 2.5 2 0 0 2 2 2 1 SET domain TPR_7 PF13176.1 ESL06300.1 - 0.0014 18.2 0.5 0.058 13.2 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Mu-like_Com PF10122.4 ESL06300.1 - 3.2 6.8 6.1 3.2 6.8 0.4 2.8 1 1 1 2 2 2 0 Mu-like prophage protein Com BLYB PF05289.6 ESL06301.1 - 0.009 15.8 0.0 0.056 13.2 0.0 2.0 2 0 0 2 2 2 1 Borrelia hemolysin accessory protein PTR2 PF00854.16 ESL06303.1 - 1.6e-14 53.4 1.9 1.8e-14 53.2 0.7 1.5 2 0 0 2 2 2 1 POT family Peptidase_M8 PF01457.11 ESL06304.1 - 3.5e-42 144.4 0.6 4e-42 144.2 0.4 1.0 1 0 0 1 1 1 1 Leishmanolysin TruD PF01142.13 ESL06305.1 - 2.2e-38 131.9 0.0 7.9e-36 123.5 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) PriCT_2 PF08707.6 ESL06306.1 - 2.9e-16 59.0 0.5 6e-16 58.0 0.4 1.5 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) RRM_1 PF00076.17 ESL06307.1 - 2.9e-30 103.7 0.0 3.1e-15 55.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06307.1 - 2e-20 72.5 0.0 1.6e-10 40.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06307.1 - 4.9e-13 48.7 0.1 6.6e-07 29.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ArfGap PF01412.13 ESL06309.1 - 1.5 8.5 9.1 0.61 9.8 2.3 2.7 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf NicO PF03824.11 ESL06310.1 - 0.093 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein Tmemb_185A PF10269.4 ESL06311.1 - 2.8e-08 33.6 15.9 0.00013 21.6 5.7 2.3 2 0 0 2 2 2 2 Transmembrane Fragile-X-F protein ATPase_gene1 PF09527.5 ESL06311.1 - 1.7 8.5 12.6 5.2 6.9 0.9 2.8 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit (ATPase_gene1) zf-DHHC PF01529.15 ESL06311.1 - 4.1 6.7 11.8 14 5.0 0.1 3.4 2 2 1 3 3 3 0 DHHC palmitoyltransferase DUF2207 PF09972.4 ESL06311.1 - 7.3 5.0 7.9 0.76 8.2 1.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ank_2 PF12796.2 ESL06313.1 - 1.7e-91 300.7 26.8 3.9e-15 55.9 0.2 17.1 9 6 7 17 17 17 12 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL06313.1 - 7e-64 211.1 39.3 2.1e-09 37.6 0.0 18.2 15 3 4 20 20 20 12 Ankyrin repeats (many copies) Ank PF00023.25 ESL06313.1 - 2.1e-57 188.1 64.7 2.4e-07 30.1 0.0 24.1 24 0 0 24 24 24 16 Ankyrin repeat Ank_5 PF13857.1 ESL06313.1 - 1.8e-46 155.1 54.3 3.2e-10 39.9 0.1 19.7 14 5 7 21 21 21 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL06313.1 - 5.9e-44 143.6 44.0 0.0001 22.1 0.0 24.1 25 0 0 25 25 25 10 Ankyrin repeat Pex24p PF06398.6 ESL06313.1 - 1.2 7.9 0.0 1.8 7.2 0.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin HpcH_HpaI PF03328.9 ESL06314.1 - 6.8e-60 201.6 0.0 8e-60 201.4 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Response_reg PF00072.19 ESL06314.1 - 0.0072 16.3 0.0 0.019 14.9 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain DHQS PF01959.11 ESL06314.1 - 0.025 13.2 0.0 0.039 12.6 0.0 1.3 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) TPR_11 PF13414.1 ESL06315.1 - 2.3e-24 84.8 10.5 2.1e-10 40.0 0.2 4.4 3 1 1 4 4 4 3 TPR repeat TPR_2 PF07719.12 ESL06315.1 - 7.7e-14 50.4 12.7 0.0088 15.8 0.6 5.9 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06315.1 - 3.4e-11 43.5 6.0 1.7e-08 34.9 0.6 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06315.1 - 2e-09 36.6 10.6 0.072 12.7 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06315.1 - 2.1e-08 33.9 11.1 0.0022 17.9 0.5 4.3 3 2 1 4 4 4 3 Tetratricopeptide repeat CS PF04969.11 ESL06315.1 - 4.6e-08 33.4 0.0 7.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 CS domain TPR_19 PF14559.1 ESL06315.1 - 3e-07 30.6 5.0 2.1e-05 24.7 0.3 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06315.1 - 1.7e-06 28.1 5.2 0.71 10.6 0.1 5.2 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06315.1 - 2.2e-05 23.9 6.7 0.074 12.8 0.1 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL06315.1 - 0.00068 19.4 10.6 0.35 10.8 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06315.1 - 0.012 15.3 0.9 14 5.7 0.0 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESL06315.1 - 0.018 14.8 7.0 3.2 7.6 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06315.1 - 0.023 15.1 1.1 3.9 8.1 0.2 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESL06315.1 - 0.024 14.7 2.6 0.042 13.9 0.1 2.8 3 1 0 3 3 2 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESL06315.1 - 0.046 13.9 3.7 2.6 8.2 0.2 2.7 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_17 PF13431.1 ESL06315.1 - 0.076 13.2 1.2 0.22 11.7 0.0 2.6 3 0 0 3 3 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL06315.1 - 0.18 11.6 2.5 0.2 11.5 0.1 2.4 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat Apc3 PF12895.2 ESL06315.1 - 0.25 11.5 13.6 0.37 10.9 0.5 4.1 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF1282 PF06930.7 ESL06316.1 - 0.14 11.7 0.0 0.16 11.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) DUF1049 PF06305.6 ESL06317.1 - 0.023 14.1 1.0 0.073 12.5 0.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Adeno_E3B PF03376.9 ESL06317.1 - 0.073 12.9 3.3 5.3 7.0 0.0 3.3 3 0 0 3 3 3 0 Adenovirus E3B protein AAA_25 PF13481.1 ESL06318.1 - 3.1e-06 26.7 0.4 1.4e-05 24.5 0.3 1.9 1 1 0 1 1 1 1 AAA domain RecA PF00154.16 ESL06318.1 - 1.4e-05 24.3 0.0 2.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.6 ESL06318.1 - 7e-05 21.8 0.0 0.00024 20.1 0.0 1.8 2 0 0 2 2 2 1 Rad51 AAA_16 PF13191.1 ESL06318.1 - 0.0055 16.7 0.1 0.014 15.3 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 ESL06318.1 - 0.021 14.7 0.0 0.053 13.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESL06318.1 - 0.022 14.9 0.0 0.7 10.0 0.0 2.4 1 1 0 1 1 1 0 AAA domain ArgK PF03308.11 ESL06318.1 - 0.077 11.7 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 ArgK protein Sigma70_r3 PF04539.11 ESL06319.1 - 0.14 12.0 0.9 0.31 10.9 0.6 1.6 1 0 0 1 1 1 0 Sigma-70 region 3 Atg14 PF10186.4 ESL06320.1 - 0.99 8.2 31.4 0.12 11.2 8.0 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Y_phosphatase3C PF13348.1 ESL06321.1 - 0.012 15.7 0.1 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family C-terminal region SET PF00856.23 ESL06322.1 - 2e-09 37.9 0.0 4e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.13 ESL06322.1 - 1.5e-05 24.7 7.8 6.6e-05 22.6 5.4 2.3 1 0 0 1 1 1 1 MYND finger TPR_2 PF07719.12 ESL06322.1 - 0.038 13.8 1.4 0.68 9.9 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06322.1 - 0.04 13.5 2.6 0.17 11.5 0.1 2.6 2 1 0 2 2 2 0 TPR repeat TPR_1 PF00515.23 ESL06322.1 - 0.18 11.4 1.0 1 9.0 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06322.1 - 0.36 11.5 1.6 1 10.1 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.2 ESL06325.1 - 2.4e-42 141.8 37.7 0.00017 21.1 0.0 14.8 8 4 10 19 19 19 14 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL06325.1 - 2.3e-28 95.0 58.8 0.03 14.3 0.0 20.4 21 1 1 22 22 22 11 Leucine Rich repeat LRR_8 PF13855.1 ESL06325.1 - 3e-28 97.3 54.3 0.0015 18.2 0.4 12.0 5 4 8 14 14 14 12 Leucine rich repeat LRR_1 PF00560.28 ESL06325.1 - 4.2e-12 44.3 65.8 0.97 9.7 0.1 19.1 19 3 1 20 20 20 7 Leucine Rich Repeat LRR_5 PF13306.1 ESL06325.1 - 2.4e-06 27.2 1.1 0.33 10.6 0.1 5.1 2 1 2 6 6 6 1 Leucine rich repeats (6 copies) LRR_7 PF13504.1 ESL06325.1 - 4.3e-06 26.0 69.6 2.5 8.6 0.1 19.6 21 2 0 21 21 21 3 Leucine rich repeat LRR_9 PF14580.1 ESL06325.1 - 5.8 6.4 18.1 0.99 8.9 0.8 4.8 2 2 3 5 5 5 0 Leucine-rich repeat ThiF PF00899.16 ESL06326.1 - 7e-33 113.3 1.1 1.2e-32 112.5 0.8 1.3 1 0 0 1 1 1 1 ThiF family KR PF08659.5 ESL06326.1 - 0.021 14.4 0.6 0.052 13.2 0.1 1.8 2 0 0 2 2 2 0 KR domain adh_short PF00106.20 ESL06326.1 - 0.043 13.7 0.6 0.1 12.4 0.2 1.8 2 0 0 2 2 2 0 short chain dehydrogenase TTL PF03133.10 ESL06327.1 - 1.5e-35 122.6 0.0 1.7e-35 122.3 0.0 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family AAA_2 PF07724.9 ESL06328.1 - 4.4e-54 182.9 1.2 1.6e-52 177.8 0.0 3.4 3 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESL06328.1 - 4.7e-28 98.0 0.0 7.8e-15 55.2 0.0 3.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL06328.1 - 2.4e-17 62.9 0.1 1.2e-11 44.5 0.0 3.6 2 2 1 3 3 3 2 AAA domain (dynein-related subfamily) Clp_N PF02861.15 ESL06328.1 - 3.9e-17 61.9 1.2 5.6e-08 32.5 0.5 3.1 2 0 0 2 2 2 2 Clp amino terminal domain ClpB_D2-small PF10431.4 ESL06328.1 - 6.9e-14 51.5 5.7 2.8e-13 49.5 0.0 3.8 3 0 0 3 3 3 1 C-terminal, D2-small domain, of ClpB protein Sigma54_activat PF00158.21 ESL06328.1 - 3.2e-10 39.7 0.0 9.1e-07 28.4 0.0 3.2 2 2 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.1 ESL06328.1 - 1.6e-09 38.0 8.6 0.0042 17.0 0.0 5.1 3 2 2 5 5 5 2 AAA ATPase domain AAA_22 PF13401.1 ESL06328.1 - 3.2e-09 37.0 1.6 0.0013 18.8 0.0 4.1 2 1 2 4 4 4 2 AAA domain IstB_IS21 PF01695.12 ESL06328.1 - 8e-09 35.1 0.1 0.0031 16.9 0.0 3.0 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_14 PF13173.1 ESL06328.1 - 1.3e-08 34.8 0.1 0.0088 15.9 0.0 3.8 4 0 0 4 4 4 2 AAA domain NACHT PF05729.7 ESL06328.1 - 2.4e-07 30.5 0.0 0.023 14.3 0.0 3.7 3 0 0 3 3 3 2 NACHT domain Zeta_toxin PF06414.7 ESL06328.1 - 5e-07 29.0 0.4 0.00019 20.6 0.0 4.0 5 0 0 5 5 4 1 Zeta toxin AAA_17 PF13207.1 ESL06328.1 - 1.5e-06 29.0 5.4 0.0069 17.1 0.0 4.0 2 2 0 3 3 2 2 AAA domain AAA_19 PF13245.1 ESL06328.1 - 1.1e-05 25.1 0.1 0.14 11.9 0.0 3.2 2 1 0 2 2 2 2 Part of AAA domain AAA_25 PF13481.1 ESL06328.1 - 1.8e-05 24.2 1.6 0.074 12.4 0.0 4.1 4 1 0 4 4 4 2 AAA domain AAA_18 PF13238.1 ESL06328.1 - 6.9e-05 23.1 5.1 0.066 13.5 0.0 3.8 3 1 1 4 4 3 2 AAA domain Mg_chelatase PF01078.16 ESL06328.1 - 0.00028 20.0 0.1 0.88 8.6 0.0 3.5 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 ESL06328.1 - 0.0006 18.9 3.3 0.35 9.8 0.0 3.9 3 1 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus Bac_DnaA PF00308.13 ESL06328.1 - 0.00072 19.2 0.0 2.1 7.9 0.0 3.9 3 0 0 3 3 3 1 Bacterial dnaA protein TIP49 PF06068.8 ESL06328.1 - 0.00081 18.2 0.1 0.12 11.0 0.0 3.0 2 1 1 3 3 3 1 TIP49 C-terminus RNA_helicase PF00910.17 ESL06328.1 - 0.00083 19.5 0.0 1.9 8.6 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA_3 PF07726.6 ESL06328.1 - 0.0011 18.5 0.1 0.44 10.1 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 ESL06328.1 - 0.0013 18.5 8.1 1.3 8.7 0.0 4.5 3 2 0 3 3 3 1 Archaeal ATPase MMR_HSR1 PF01926.18 ESL06328.1 - 0.0013 18.6 0.1 0.074 13.0 0.0 3.2 3 1 0 3 3 2 1 50S ribosome-binding GTPase DUF815 PF05673.8 ESL06328.1 - 0.003 16.5 0.0 2.5 6.9 0.0 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.1 ESL06328.1 - 0.0056 16.5 0.0 0.8 9.5 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESL06328.1 - 0.0056 16.1 0.0 4.2 6.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF258 PF03193.11 ESL06328.1 - 0.011 14.9 0.0 3.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ResIII PF04851.10 ESL06328.1 - 0.011 15.6 0.0 1.4 8.7 0.0 3.5 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_23 PF13476.1 ESL06328.1 - 0.011 16.0 23.4 1.4 9.2 0.0 4.7 4 1 1 5 5 4 0 AAA domain PhoH PF02562.11 ESL06328.1 - 0.015 14.5 0.3 0.24 10.6 0.0 2.7 3 0 0 3 3 2 0 PhoH-like protein AAA_28 PF13521.1 ESL06328.1 - 0.022 14.6 1.1 7.5 6.4 0.0 3.5 3 1 0 3 3 3 0 AAA domain ABC_tran PF00005.22 ESL06328.1 - 0.025 14.8 5.0 2 8.6 0.0 4.1 5 1 0 5 5 3 0 ABC transporter UPF0079 PF02367.12 ESL06328.1 - 0.029 13.9 0.2 13 5.3 0.0 2.9 3 0 0 3 3 2 0 Uncharacterised P-loop hydrolase UPF0079 NTPase_1 PF03266.10 ESL06328.1 - 0.034 13.8 3.8 5.3 6.7 0.0 3.9 4 0 0 4 4 4 0 NTPase Miro PF08477.8 ESL06328.1 - 0.042 14.3 0.0 3.5 8.1 0.0 3.2 2 0 0 2 2 2 0 Miro-like protein MobB PF03205.9 ESL06328.1 - 0.045 13.4 0.0 4.1 7.0 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.24 ESL06328.1 - 0.046 13.2 0.0 2.3 7.6 0.0 3.1 2 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_10 PF12846.2 ESL06328.1 - 0.089 12.2 5.0 2.1 7.7 0.0 4.1 4 1 0 5 5 4 0 AAA-like domain V_ATPase_I PF01496.14 ESL06328.1 - 0.26 9.1 8.5 0.43 8.3 5.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.1 ESL06328.1 - 0.7 8.2 9.9 1.6 7.1 6.9 1.5 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 ESL06328.1 - 2.5 7.6 26.2 0.077 12.5 13.2 2.1 2 1 0 2 2 1 0 IncA protein DDR PF08841.5 ESL06329.1 - 0.0037 16.1 1.4 0.0052 15.6 1.0 1.1 1 0 0 1 1 1 1 Diol dehydratase reactivase ATPase-like domain GAS PF13851.1 ESL06329.1 - 0.0049 16.0 15.8 0.02 14.1 0.7 2.1 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding DUF1967 PF09269.6 ESL06329.1 - 0.035 13.7 1.1 2.7 7.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) BTV_NS2 PF04514.7 ESL06329.1 - 0.4 9.5 8.1 0.47 9.2 5.6 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 UPF0184 PF03670.8 ESL06329.1 - 3.9 7.7 5.3 5.2 7.3 0.4 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) DUF972 PF06156.8 ESL06329.1 - 4.6 7.6 13.4 1.5 9.2 2.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Abhydrolase_5 PF12695.2 ESL06330.1 - 0.0012 18.6 0.0 0.005 16.5 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family WD40 PF00400.27 ESL06332.1 - 1.8e-40 135.3 14.5 8.7e-11 41.2 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat NLE PF08154.7 ESL06332.1 - 1e-15 57.4 0.0 1.9e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 ESL06332.1 - 0.018 13.1 0.8 0.16 10.0 0.1 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.7 ESL06332.1 - 0.2 11.3 0.5 1.1e+02 2.6 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat SPRY PF00622.23 ESL06333.1 - 1.3e-08 34.9 0.0 3.2e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 SPRY domain DUF4150 PF13665.1 ESL06336.1 - 0.27 11.1 1.6 6.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4150) Tubulin_C PF03953.12 ESL06337.1 - 6.9e-43 145.6 0.1 8.8e-43 145.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Ribosomal_S19e PF01090.14 ESL06338.1 - 3.4e-43 146.4 0.0 4e-43 146.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19e DUF1323 PF07037.6 ESL06339.1 - 0.011 15.9 0.1 0.041 14.0 0.0 2.0 2 1 1 3 3 3 0 Putative transcription regulator (DUF1323) Nup54 PF13874.1 ESL06339.1 - 0.047 13.3 0.4 0.13 11.9 0.1 1.9 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 YopR_core PF09025.5 ESL06339.1 - 0.076 13.0 0.8 0.42 10.5 0.3 2.1 2 0 0 2 2 2 0 YopR Core DEAD PF00270.24 ESL06340.1 - 4.4e-17 62.0 0.0 8.6e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06340.1 - 1.5e-10 40.7 0.0 3.5e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 ESL06340.1 - 0.00085 19.4 0.0 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.1 ESL06340.1 - 0.00087 19.2 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) ResIII PF04851.10 ESL06340.1 - 0.006 16.4 0.0 0.018 14.8 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Cdd1 PF11731.3 ESL06340.1 - 0.16 11.9 0.0 0.51 10.2 0.0 1.8 2 0 0 2 2 2 0 Pathogenicity locus DUF1761 PF08570.5 ESL06341.1 - 0.019 14.9 5.5 0.041 13.9 3.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1761) NMD3 PF04981.8 ESL06342.1 - 3.3e-72 242.4 3.0 4.9e-72 241.8 2.0 1.3 1 0 0 1 1 1 1 NMD3 family zf-TFIIB PF13453.1 ESL06342.1 - 4.1 6.6 7.9 1.8 7.8 1.1 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger DZR PF12773.2 ESL06342.1 - 7.7 6.4 12.0 6.8 6.5 3.0 2.8 2 1 0 2 2 2 0 Double zinc ribbon Pkinase PF00069.20 ESL06343.1 - 1.7e-24 86.3 0.0 2.2e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06343.1 - 1e-10 41.1 0.0 1.7e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESL06343.1 - 8.6e-05 21.6 0.0 0.00013 21.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESL06343.1 - 0.0057 16.0 0.1 0.0085 15.4 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESL06343.1 - 0.0082 15.9 0.4 0.026 14.2 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL06343.1 - 0.011 14.7 0.0 0.016 14.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Exo_endo_phos PF03372.18 ESL06344.1 - 5.3e-08 33.1 0.0 1.3e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GTP_EFTU PF00009.22 ESL06345.1 - 1.9e-58 197.0 0.0 4.1e-58 195.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 ESL06345.1 - 2.3e-25 88.2 0.1 7.6e-25 86.5 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.19 ESL06345.1 - 2.3e-20 72.2 0.1 6.8e-20 70.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.13 ESL06345.1 - 2.3e-14 52.9 0.0 7e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.20 ESL06345.1 - 8.2e-08 32.2 0.2 3.9e-07 30.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESL06345.1 - 0.0062 16.4 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF442 PF04273.8 ESL06345.1 - 0.028 14.2 0.0 9.7 6.1 0.0 2.6 2 0 0 2 2 2 0 Putative phosphatase (DUF442) AIG1 PF04548.11 ESL06345.1 - 0.037 13.1 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 AIG1 family CLAMP PF14769.1 ESL06346.1 - 1.9e-05 24.7 0.2 0.00075 19.5 0.0 2.9 3 0 0 3 3 3 1 Flagellar C1a complex subunit C1a-32 Fe_dep_repr_C PF02742.10 ESL06346.1 - 8.3 6.1 7.8 19 5.0 0.5 3.6 3 1 1 4 4 4 0 Iron dependent repressor, metal binding and dimerisation domain UVR PF02151.14 ESL06347.1 - 3e-08 32.9 6.6 0.00084 18.7 1.9 2.6 2 0 0 2 2 2 2 UvrB/uvrC motif HEAT PF02985.17 ESL06347.1 - 5.2e-07 29.2 2.1 0.52 10.5 0.0 4.3 4 0 0 4 4 4 3 HEAT repeat zf-Di19 PF05605.7 ESL06347.1 - 0.00016 21.7 11.5 0.00038 20.5 2.7 3.2 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding CLASP_N PF12348.3 ESL06347.1 - 0.0017 17.7 0.0 0.0052 16.1 0.0 1.7 1 1 0 1 1 1 1 CLASP N terminal HEAT_2 PF13646.1 ESL06347.1 - 0.0049 17.1 0.2 1.9 8.8 0.0 2.9 2 1 1 3 3 3 1 HEAT repeats HEAT_EZ PF13513.1 ESL06347.1 - 0.008 16.6 1.0 3.3 8.3 0.0 3.7 2 1 1 3 3 3 1 HEAT-like repeat ApoA-II PF04711.8 ESL06348.1 - 0.12 12.3 0.1 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) Amastin PF07344.6 ESL06350.1 - 7.2e-06 25.6 10.4 7.2e-06 25.6 7.2 2.0 1 1 1 2 2 2 1 Amastin surface glycoprotein PMP22_Claudin PF00822.15 ESL06350.1 - 4.2e-05 23.2 8.6 5.7e-05 22.8 6.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.1 ESL06350.1 - 0.092 12.4 17.4 0.01 15.5 7.2 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF3040 PF11239.3 ESL06350.1 - 3.3 7.8 7.6 0.23 11.5 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Arginase PF00491.16 ESL06351.1 - 4.4e-49 167.2 0.0 5e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family NUDIX PF00293.23 ESL06352.1 - 2.1e-08 33.8 0.1 7.1e-08 32.1 0.1 1.8 1 1 0 1 1 1 1 NUDIX domain RNA_pol_Rpb4 PF03874.11 ESL06353.1 - 6.4e-05 22.9 0.0 0.00014 21.8 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb4 A_deaminase PF00962.17 ESL06354.1 - 4.5e-42 144.1 0.0 6.1e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Dmrt1 PF12374.3 ESL06354.1 - 0.52 10.6 5.4 8.5 6.8 0.6 3.5 3 0 0 3 3 3 0 Double-sex mab3 related transcription factor 1 DUF607 PF04678.8 ESL06355.1 - 8.4e-21 74.6 0.2 8.8e-21 74.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF607 Snf7 PF03357.16 ESL06358.1 - 3.1e-33 114.5 17.2 3.7e-33 114.3 11.9 1.1 1 0 0 1 1 1 1 Snf7 WEMBL PF05701.6 ESL06358.1 - 3.9e-05 22.3 7.8 4.7e-05 22.0 5.4 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light NPV_P10 PF05531.7 ESL06358.1 - 0.0012 19.0 2.9 0.0027 17.9 0.9 2.3 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Arena_RNA_pol PF06317.6 ESL06358.1 - 0.0025 14.5 1.2 0.0029 14.3 0.8 1.0 1 0 0 1 1 1 1 Arenavirus RNA polymerase DUF3584 PF12128.3 ESL06358.1 - 0.06 10.6 11.2 0.075 10.3 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Ndr PF03096.9 ESL06358.1 - 0.19 10.1 1.5 0.26 9.7 1.1 1.2 1 0 0 1 1 1 0 Ndr family AAA_23 PF13476.1 ESL06358.1 - 0.99 9.6 4.3 1.1 9.5 3.0 1.2 1 0 0 1 1 1 0 AAA domain VIT1 PF01988.14 ESL06358.1 - 3.8 6.9 6.6 2.2 7.6 0.8 2.0 1 1 1 2 2 2 0 VIT family DUF1664 PF07889.7 ESL06358.1 - 6.2 6.6 11.0 11 5.8 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CNH PF00780.17 ESL06359.1 - 1.1e-07 31.6 0.0 2e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 CNH domain RNase_HII PF01351.13 ESL06360.1 - 7e-41 140.0 0.0 1e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII RFX5_DNA_bdg PF14621.1 ESL06360.1 - 0.046 13.3 0.6 0.12 11.9 0.0 1.9 2 1 0 2 2 2 0 RFX5 DNA-binding domain MutS_V PF00488.16 ESL06361.1 - 1.9e-31 109.2 0.1 3.6e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESL06361.1 - 7.5e-25 87.9 0.3 1.4e-24 87.0 0.1 1.6 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.13 ESL06361.1 - 0.00036 20.6 0.0 0.00077 19.5 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_22 PF13401.1 ESL06361.1 - 0.0026 17.9 0.0 0.0067 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ESL06361.1 - 0.0061 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 ESL06361.1 - 0.011 15.7 0.0 0.026 14.4 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.14 ESL06361.1 - 0.015 14.5 0.1 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_19 PF13245.1 ESL06361.1 - 0.033 13.9 0.1 0.24 11.1 0.1 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_23 PF13476.1 ESL06361.1 - 0.035 14.4 0.0 0.062 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESL06361.1 - 0.065 12.7 0.1 0.27 10.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.1 ESL06361.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.4 ESL06361.1 - 0.12 11.2 0.0 0.89 8.4 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 MIT PF04212.13 ESL06363.1 - 0.0012 18.6 0.1 0.002 17.9 0.1 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain NifU PF01106.12 ESL06364.1 - 1.7e-18 66.1 0.1 2.8e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.6 ESL06364.1 - 1.2e-05 24.8 0.0 2.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal zf-C2H2_2 PF12756.2 ESL06365.1 - 5.9e-28 96.9 8.8 1.6e-19 69.8 0.0 3.3 2 1 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 ESL06365.1 - 2.2e-08 34.0 13.3 8e-06 25.8 0.8 4.5 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESL06365.1 - 6.2e-07 29.1 6.6 0.007 16.2 0.6 4.0 3 1 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.2 ESL06365.1 - 0.00036 20.6 12.9 0.00074 19.6 1.5 3.6 4 0 0 4 4 4 2 Zinc-finger of C2H2 type Activator_LAG-3 PF11498.3 ESL06365.1 - 0.0011 17.8 6.4 0.014 14.1 0.6 2.1 2 0 0 2 2 2 2 Transcriptional activator LAG-3 zf-C2H2 PF00096.21 ESL06365.1 - 0.0014 18.8 17.2 0.15 12.4 1.0 4.6 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-FCS PF06467.9 ESL06365.1 - 0.049 13.2 3.0 8.9 6.0 0.1 3.3 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 PF13894.1 ESL06365.1 - 0.084 13.2 21.0 0.4 11.1 0.8 4.7 5 1 0 5 5 5 0 C2H2-type zinc finger SID-1_RNA_chan PF13965.1 ESL06365.1 - 0.27 9.3 0.6 0.46 8.6 0.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AKAP95 PF04988.7 ESL06365.1 - 0.34 10.6 9.0 3.5 7.3 0.0 3.1 3 1 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Antimicrobial10 PF08105.6 ESL06367.1 - 0.1 12.2 3.4 4.4 6.9 0.3 2.5 2 0 0 2 2 2 0 Metchnikowin family NAD_binding_11 PF14833.1 ESL06369.1 - 0.00038 20.5 0.5 0.0013 18.7 0.1 2.1 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DnaJ PF00226.26 ESL06370.1 - 4.7e-15 55.0 0.8 8.3e-15 54.2 0.6 1.4 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.27 ESL06371.1 - 5.7e-15 54.5 5.0 0.012 15.5 0.0 8.4 8 0 0 8 8 8 4 WD domain, G-beta repeat DUF3312 PF11768.3 ESL06371.1 - 0.013 13.7 0.1 0.033 12.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) Pkinase PF00069.20 ESL06372.1 - 7.5e-79 264.5 0.0 1.2e-78 263.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06372.1 - 1.6e-43 148.6 0.0 2.9e-43 147.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.1 ESL06372.1 - 4.4e-12 46.1 0.1 0.00058 20.0 0.0 4.2 3 1 1 4 4 4 2 HEAT repeats Arm PF00514.18 ESL06372.1 - 8e-10 38.1 0.4 0.00028 20.5 0.0 5.2 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT PF02985.17 ESL06372.1 - 1.1e-08 34.4 0.4 0.032 14.3 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 ESL06372.1 - 2.1e-07 31.2 0.1 0.068 13.6 0.0 5.0 4 1 1 5 5 4 1 HEAT-like repeat Kinase-like PF14531.1 ESL06372.1 - 9.1e-07 28.1 0.0 4.4e-06 25.8 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESL06372.1 - 0.0012 17.9 0.0 0.0022 17.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL06372.1 - 0.0044 16.7 0.0 0.053 13.2 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESL06372.1 - 0.0053 16.1 1.0 0.016 14.5 0.7 1.7 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESL06372.1 - 0.0054 16.0 0.1 0.014 14.7 0.1 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIX1 PF08167.7 ESL06372.1 - 0.064 12.9 0.0 0.22 11.2 0.0 1.9 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis NEMO PF11577.3 ESL06372.1 - 4.6 7.0 6.8 1.5 8.6 0.2 3.1 3 0 0 3 3 3 0 NF-kappa-B essential modulator NEMO RNA_pol_Rpb6 PF01192.17 ESL06374.1 - 3.3e-20 71.5 0.2 5.3e-20 70.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 TrkH PF02386.11 ESL06375.1 - 6.3e-18 64.4 25.4 1.1e-08 34.1 2.3 4.1 3 1 1 4 4 4 4 Cation transport protein DUF3969 PF13108.1 ESL06375.1 - 0.12 12.0 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3969) DEAD PF00270.24 ESL06376.1 - 1.1e-45 155.1 0.3 1e-44 152.0 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06376.1 - 1.4e-23 82.5 0.1 2.8e-23 81.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06376.1 - 0.00011 22.0 0.9 0.00064 19.6 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESL06376.1 - 0.0014 17.4 0.0 0.0025 16.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain EF-hand_7 PF13499.1 ESL06377.1 - 3.7e-08 33.3 0.1 0.26 11.4 0.0 4.7 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.1 ESL06377.1 - 8.4e-05 22.1 0.1 11 6.2 0.0 4.7 5 0 0 5 5 5 2 EF-hand domain Aa_trans PF01490.13 ESL06379.1 - 2.2e-40 138.4 26.8 2.6e-40 138.1 18.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Autophagy_N PF03986.8 ESL06380.1 - 2.5e-34 118.1 1.6 2.8e-34 117.9 0.3 1.6 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 ESL06380.1 - 6.2e-23 80.7 0.3 1.4e-22 79.5 0.2 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 ESL06380.1 - 7.2e-14 50.5 1.4 1.4e-13 49.6 1.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal RRP7 PF12923.2 ESL06380.1 - 0.14 12.1 1.8 7 6.6 0.1 2.2 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) Anoctamin PF04547.7 ESL06381.1 - 0.097 11.3 1.3 0.22 10.1 0.9 1.5 1 1 0 1 1 1 0 Calcium-activated chloride channel Pkinase PF00069.20 ESL06382.1 - 6.1e-75 251.7 0.0 9.2e-75 251.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06382.1 - 7e-41 140.0 0.0 1.1e-40 139.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06382.1 - 1.1e-07 31.1 0.0 4.7e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESL06382.1 - 0.00025 20.1 0.0 0.00048 19.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL06382.1 - 0.07 12.8 0.0 1.7 8.3 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family VHS PF00790.14 ESL06383.1 - 1.8e-15 56.7 0.1 5.8e-15 55.1 0.0 1.7 2 0 0 2 2 2 1 VHS domain 5_3_exonuc_N PF02739.11 ESL06383.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain HipA_C PF07804.7 ESL06383.1 - 0.099 12.7 0.1 0.31 11.1 0.1 1.9 1 0 0 1 1 1 0 HipA-like C-terminal domain SpoU_methylase PF00588.14 ESL06384.1 - 1.1e-07 31.7 0.0 3.1e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 SpoU rRNA Methylase family Ku PF02735.11 ESL06385.1 - 0.072 12.4 0.1 0.22 10.9 0.1 1.8 1 1 1 2 2 2 0 Ku70/Ku80 beta-barrel domain HEAT PF02985.17 ESL06387.1 - 1.6e-27 93.0 12.0 0.011 15.8 0.0 10.7 10 0 0 10 10 10 9 HEAT repeat HEAT_2 PF13646.1 ESL06387.1 - 1.9e-20 72.9 2.8 0.00031 20.9 0.0 7.1 4 1 4 8 8 8 8 HEAT repeats HEAT_EZ PF13513.1 ESL06387.1 - 0.006 17.0 7.8 29 5.3 0.1 6.0 7 1 0 7 7 7 1 HEAT-like repeat Skp1_POZ PF03931.10 ESL06387.1 - 0.094 12.8 0.3 3.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Skp1 PF01466.14 ESL06388.1 - 0.0047 16.9 0.0 0.0079 16.1 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain PNK3P PF08645.6 ESL06389.1 - 9.5e-08 31.6 0.0 1.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Arv1 PF04161.8 ESL06390.1 - 1e-22 81.0 8.2 1.4e-22 80.6 5.7 1.1 1 0 0 1 1 1 1 Arv1-like family FAM70 PF14967.1 ESL06390.1 - 0.0037 16.5 2.9 0.0051 16.0 1.8 1.3 1 1 0 1 1 1 1 FAM70 protein Methyltransf_23 PF13489.1 ESL06391.1 - 0.009 15.7 0.0 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF2849 PF11011.3 ESL06391.1 - 0.024 14.8 0.9 12 6.2 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2849) HSP90 PF00183.13 ESL06393.1 - 1.2e-144 482.6 8.0 2.3e-142 475.1 3.5 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.1 ESL06393.1 - 9.3e-09 35.0 0.0 2.1e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESL06393.1 - 1.4e-06 27.9 0.0 2.8e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HTH_17 PF12728.2 ESL06394.1 - 0.0083 16.3 0.0 0.042 14.1 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain SF3b10 PF07189.6 ESL06395.1 - 3.5e-13 49.1 0.0 3.9e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) TauE PF01925.14 ESL06397.1 - 1.6e-14 53.9 28.9 1e-09 38.2 3.2 2.3 1 1 1 2 2 2 2 Sulfite exporter TauE/SafE DUF3844 PF12955.2 ESL06397.1 - 0.066 13.3 2.9 0.22 11.6 2.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) ECH PF00378.15 ESL06398.1 - 1.5e-55 187.9 0.4 1.7e-55 187.7 0.3 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family DUF4031 PF13223.1 ESL06398.1 - 0.28 11.3 1.3 0.8 9.8 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4031) EB1 PF03271.12 ESL06399.1 - 6.9e-10 38.8 0.0 1.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif Kinesin PF00225.18 ESL06400.1 - 2.5e-58 197.4 0.0 2.7e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 ESL06400.1 - 0.049 13.7 0.0 0.074 13.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESL06400.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain PEPCK_ATP PF01293.15 ESL06402.1 - 5.7e-197 654.8 0.0 7e-197 654.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 ESL06402.1 - 0.015 15.1 0.0 0.071 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESL06402.1 - 0.051 13.5 0.0 0.22 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.1 ESL06402.1 - 0.095 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESL06402.1 - 0.16 11.5 0.1 0.4 10.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.24 ESL06403.1 - 1.1e-37 129.1 0.0 2.1e-37 128.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESL06403.1 - 5.1e-07 29.4 0.0 2.2e-06 27.4 0.0 2.1 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.9 ESL06403.1 - 1.1e-06 28.3 0.0 6.2e-06 25.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESL06403.1 - 0.00013 21.1 0.0 0.00051 19.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL06403.1 - 0.00021 21.3 0.1 0.0018 18.2 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 ESL06403.1 - 0.00029 20.5 0.1 0.00069 19.3 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 ESL06403.1 - 0.00044 20.4 0.1 0.0076 16.3 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESL06403.1 - 0.00072 20.3 0.0 0.0014 19.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESL06403.1 - 0.00079 19.3 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.1 ESL06403.1 - 0.0018 17.7 0.1 0.0048 16.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 ESL06403.1 - 0.0021 17.9 0.0 0.0032 17.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_14 PF13173.1 ESL06403.1 - 0.0029 17.4 0.0 0.0055 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESL06403.1 - 0.0029 17.2 0.1 1.1 8.8 0.0 2.3 1 1 1 2 2 2 1 NACHT domain IstB_IS21 PF01695.12 ESL06403.1 - 0.0041 16.5 0.0 0.0074 15.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESL06403.1 - 0.011 14.9 0.1 0.032 13.3 0.0 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESL06403.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESL06403.1 - 0.016 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESL06403.1 - 0.018 13.7 0.0 0.029 13.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus ABC_tran PF00005.22 ESL06403.1 - 0.02 15.1 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF815 PF05673.8 ESL06403.1 - 0.024 13.5 0.0 0.034 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.11 ESL06403.1 - 0.031 13.5 0.0 0.058 12.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 ESL06403.1 - 0.037 13.1 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 KaiC DAP3 PF10236.4 ESL06403.1 - 0.037 12.9 0.0 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.17 ESL06403.1 - 0.056 13.6 0.2 0.12 12.5 0.0 1.8 2 1 0 2 2 1 0 RNA helicase AAA_11 PF13086.1 ESL06403.1 - 0.092 12.3 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESL06403.1 - 0.11 11.9 0.0 0.43 10.0 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 ESL06403.1 - 0.13 12.3 0.1 1.3 9.1 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.1 ESL06403.1 - 0.14 12.1 0.0 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 ESL06403.1 - 0.15 10.9 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RCC1 PF00415.13 ESL06404.1 - 1.1e-28 99.1 16.8 2.3e-08 34.0 0.0 8.0 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL06404.1 - 4e-09 35.8 29.6 4.1e-05 23.0 1.3 6.9 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Cullin_binding PF03556.10 ESL06406.1 - 3.4e-20 72.3 1.6 6.2e-20 71.4 1.1 1.5 1 0 0 1 1 1 1 Cullin binding PCI PF01399.22 ESL06409.1 - 4.3e-13 49.4 0.3 1.7e-12 47.5 0.0 2.1 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 ESL06409.1 - 0.011 15.5 0.0 0.032 13.9 0.0 1.8 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 GCS PF03074.11 ESL06410.1 - 7.3e-167 555.0 0.0 1e-166 554.6 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase Peptidase_C11 PF03415.9 ESL06411.1 - 8.6e-09 34.8 0.1 1.2e-08 34.3 0.1 1.1 1 0 0 1 1 1 1 Clostripain family BEN PF10523.4 ESL06411.1 - 0.13 12.2 0.0 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 BEN domain AAA PF00004.24 ESL06412.1 - 2.2e-24 86.1 0.1 7.8e-24 84.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESL06412.1 - 5.3e-06 25.6 0.2 0.0012 17.9 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESL06412.1 - 6.6e-05 22.6 0.4 0.00031 20.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL06412.1 - 8.2e-05 22.6 1.4 0.011 15.6 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.8 ESL06412.1 - 0.00084 18.3 0.0 0.0019 17.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) KaiC PF06745.8 ESL06412.1 - 0.0017 17.5 0.8 0.088 11.9 0.0 2.6 3 0 0 3 3 3 1 KaiC Mg_chelatase PF01078.16 ESL06412.1 - 0.0034 16.5 0.0 0.0091 15.1 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESL06412.1 - 0.0054 16.4 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 ESL06412.1 - 0.0055 16.5 0.3 0.022 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESL06412.1 - 0.0085 15.2 0.6 0.019 14.0 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.12 ESL06412.1 - 0.012 15.0 0.1 0.032 13.6 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 ESL06412.1 - 0.012 15.0 4.0 0.012 14.9 0.2 2.5 2 1 1 3 3 3 0 AAA domain CPT PF07931.7 ESL06412.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.1 ESL06412.1 - 0.025 14.7 5.1 0.032 14.3 0.1 2.9 2 2 1 3 3 3 0 AAA domain AAA_3 PF07726.6 ESL06412.1 - 0.031 13.8 0.0 0.07 12.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL06412.1 - 0.041 14.7 0.8 0.19 12.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESL06412.1 - 0.041 14.0 0.0 0.15 12.2 0.0 1.9 2 1 0 2 2 2 0 RNA helicase PhoH PF02562.11 ESL06412.1 - 0.044 12.9 0.0 0.093 11.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Bacillus_HBL PF05791.6 ESL06412.1 - 0.046 13.1 4.1 0.077 12.3 2.9 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) AAA_2 PF07724.9 ESL06412.1 - 0.046 13.6 1.4 0.25 11.2 0.0 2.7 2 2 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.1 ESL06412.1 - 0.055 13.4 0.6 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 ESL06412.1 - 0.065 12.8 1.1 0.13 11.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.1 ESL06412.1 - 0.081 13.2 1.8 1.4 9.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 ESL06412.1 - 0.088 12.4 0.0 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 NACHT domain TMF_DNA_bd PF12329.3 ESL06412.1 - 0.25 11.1 12.0 0.19 11.5 6.6 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding APG6 PF04111.7 ESL06412.1 - 2.3 7.1 8.6 3.5 6.5 6.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF972 PF06156.8 ESL06412.1 - 6.6 7.1 9.1 18 5.7 4.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Actin PF00022.14 ESL06413.1 - 2.7e-34 118.2 0.0 2.9e-34 118.1 0.0 1.0 1 0 0 1 1 1 1 Actin Baculo_PEP_C PF04513.7 ESL06414.1 - 0.04 13.7 6.4 1.2 8.9 0.2 3.6 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2181 PF10223.4 ESL06415.1 - 7.7e-09 35.2 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) zf-MYND PF01753.13 ESL06416.1 - 1.6e-10 40.6 10.1 3e-10 39.8 7.0 1.5 1 0 0 1 1 1 1 MYND finger Peptidase_A22B PF04258.8 ESL06417.1 - 1.3e-49 169.3 19.5 2.4e-49 168.3 9.9 2.1 1 1 1 2 2 2 2 Signal peptide peptidase TcpE PF12648.2 ESL06417.1 - 0.01 15.9 2.6 0.01 15.9 1.8 3.4 2 1 1 3 3 3 0 TcpE family DUF1119 PF06550.6 ESL06417.1 - 0.015 14.4 21.5 0.11 11.5 14.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1119) SieB PF14163.1 ESL06417.1 - 2 7.9 6.4 2.2 7.8 0.0 2.7 2 1 1 3 3 3 0 Superinfection exclusion protein B NIF PF03031.13 ESL06418.1 - 2.3e-30 105.3 0.1 3.2e-20 72.3 0.0 2.2 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase DUF4189 PF13827.1 ESL06418.1 - 0.058 13.6 2.0 0.14 12.3 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4189) Mago_nashi PF02792.9 ESL06419.1 - 1.9e-55 186.5 0.4 2.2e-55 186.2 0.3 1.0 1 0 0 1 1 1 1 Mago nashi protein GTP_EFTU PF00009.22 ESL06421.1 - 2.2e-49 167.4 0.1 3.8e-49 166.6 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 ESL06421.1 - 3.5e-13 49.2 0.0 1.1e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 ESL06421.1 - 0.0002 21.2 0.1 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.13 ESL06421.1 - 0.0023 16.9 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Septin GTP_EFTU_D2 PF03144.20 ESL06421.1 - 0.0066 16.5 0.4 0.026 14.6 0.3 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 ESL06421.1 - 0.0084 16.5 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein DUF2293 PF10056.4 ESL06421.1 - 0.009 15.9 0.1 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) Mucin PF01456.12 ESL06421.1 - 0.16 11.7 1.3 0.25 11.1 0.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2605 PF10792.4 ESL06423.1 - 0.0038 16.8 2.7 0.034 13.8 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2605) Catalase-rel PF06628.7 ESL06423.1 - 0.027 14.3 0.0 0.077 12.8 0.0 1.8 1 0 0 1 1 1 0 Catalase-related immune-responsive Mit_ribos_Mrp51 PF11709.3 ESL06423.1 - 0.033 13.4 1.0 0.043 13.0 0.7 1.2 1 1 0 1 1 1 0 Mitochondrial ribosomal protein subunit DUF2756 PF10956.3 ESL06423.1 - 0.14 12.4 2.5 1.4 9.2 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) AAA_18 PF13238.1 ESL06424.1 - 1.5e-12 47.9 0.0 3.6e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_lig_T4_1 PF09511.5 ESL06424.1 - 1.9e-12 47.1 0.0 3.7e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 RNA ligase AAA_33 PF13671.1 ESL06424.1 - 9e-12 45.0 0.1 2.2e-11 43.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL06424.1 - 0.0011 19.8 0.1 0.0069 17.1 0.0 2.5 3 2 0 3 3 2 1 AAA domain NACHT PF05729.7 ESL06424.1 - 0.0019 17.8 0.0 0.004 16.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Zeta_toxin PF06414.7 ESL06424.1 - 0.006 15.7 0.0 0.015 14.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.5 ESL06424.1 - 0.0094 15.1 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_25 PF13481.1 ESL06424.1 - 0.019 14.3 0.0 0.047 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESL06424.1 - 0.02 15.0 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL06424.1 - 0.025 14.6 0.0 0.091 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESL06424.1 - 0.026 14.5 0.3 0.088 12.7 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain SRP54 PF00448.17 ESL06424.1 - 0.034 13.5 0.3 0.14 11.6 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.14 ESL06424.1 - 0.049 13.0 0.1 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CPT PF07931.7 ESL06424.1 - 0.056 13.0 0.1 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein UPF0079 PF02367.12 ESL06424.1 - 0.06 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 PduV-EutP PF10662.4 ESL06424.1 - 0.16 11.4 0.2 0.4 10.1 0.2 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Pro_isomerase PF00160.16 ESL06426.1 - 6.4e-38 130.3 0.0 1.1e-37 129.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CIDE-N PF02017.10 ESL06426.1 - 0.05 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 CIDE-N domain Ras PF00071.17 ESL06427.1 - 5.3e-44 149.4 0.6 6.2e-44 149.2 0.4 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL06427.1 - 8.9e-12 45.5 0.0 1.7e-11 44.6 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESL06427.1 - 1.2e-10 40.9 0.2 1.4e-10 40.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL06427.1 - 3.2e-05 23.1 0.1 3.9e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESL06427.1 - 0.00057 19.3 0.0 0.00069 19.1 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HTS PF04204.11 ESL06427.1 - 0.021 13.5 0.0 0.026 13.2 0.0 1.1 1 0 0 1 1 1 0 Homoserine O-succinyltransferase CC2D2AN-C2 PF15625.1 ESL06428.1 - 1.6e-08 34.2 0.0 3.1e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.25 ESL06428.1 - 0.0071 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF1768 PF08719.6 ESL06429.1 - 2.4e-39 134.5 0.0 2.8e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Aminotran_1_2 PF00155.16 ESL06430.1 - 9.3e-62 209.0 0.0 1.1e-61 208.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SHMT PF00464.14 ESL06430.1 - 1.2e-06 27.1 0.0 1.1e-05 23.9 0.0 2.4 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 ESL06430.1 - 4.8e-05 22.2 0.1 0.00017 20.4 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESL06430.1 - 0.00017 20.8 0.2 0.00026 20.2 0.2 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 ESL06430.1 - 0.0029 15.9 0.0 0.0058 14.9 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme HATPase_c_5 PF14501.1 ESL06430.1 - 0.067 12.9 0.0 0.2 11.3 0.0 1.8 2 0 0 2 2 2 0 GHKL domain Pkinase PF00069.20 ESL06431.1 - 5.5e-07 28.9 0.0 9.4e-07 28.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06431.1 - 5.9e-06 25.5 0.0 8.9e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.17 ESL06431.1 - 2.3e-05 24.1 0.1 0.031 14.3 0.0 4.3 5 0 0 5 5 5 1 HEAT repeat Kinase-like PF14531.1 ESL06431.1 - 6.8e-05 21.9 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like HEAT_2 PF13646.1 ESL06431.1 - 0.022 15.0 0.0 1.9 8.8 0.0 2.9 2 1 0 2 2 2 0 HEAT repeats DUF2413 PF10310.4 ESL06431.1 - 1.3 7.7 6.7 2.1 7.0 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Arginase PF00491.16 ESL06432.1 - 3.4e-34 118.3 0.0 7.5e-34 117.2 0.0 1.4 1 1 0 1 1 1 1 Arginase family GAS PF13851.1 ESL06434.1 - 0.0075 15.4 8.0 0.0075 15.4 5.5 4.4 2 1 2 4 4 4 1 Growth-arrest specific micro-tubule binding APG6 PF04111.7 ESL06434.1 - 0.039 13.0 45.7 0.018 14.1 1.8 3.3 3 0 0 3 3 3 0 Autophagy protein Apg6 Peptidase_M20 PF01546.23 ESL06435.1 - 3.6e-26 91.8 0.2 4.5e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL06435.1 - 6.4e-09 35.5 0.0 1.4e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 ESL06435.1 - 0.0094 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 mRNA_triPase PF02940.10 ESL06436.1 - 4.3e-20 72.3 0.0 5.1e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain DUF3756 PF12581.3 ESL06436.1 - 0.093 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) TF_Zn_Ribbon PF08271.7 ESL06437.1 - 8.8e-05 21.7 0.7 0.00016 20.8 0.5 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 ESL06437.1 - 0.00086 18.8 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.14 ESL06437.1 - 0.003 17.3 0.2 0.0066 16.2 0.1 1.6 1 0 0 1 1 1 1 Transcription factor TFIIB repeat DUF2387 PF09526.5 ESL06437.1 - 0.032 14.1 2.0 0.047 13.6 0.3 2.1 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Lar_restr_allev PF14354.1 ESL06437.1 - 0.05 13.8 0.3 0.12 12.7 0.2 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.1 ESL06437.1 - 0.2 10.9 1.0 0.59 9.4 0.0 2.0 2 0 0 2 2 2 0 zinc-ribbon domain PP2C PF00481.16 ESL06438.1 - 5.6e-50 170.1 0.0 6.6e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL06438.1 - 0.032 13.6 0.0 0.049 13.0 0.0 1.4 1 1 0 1 1 1 0 Protein phosphatase 2C RepA_C PF04796.7 ESL06439.1 - 0.12 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Plasmid encoded RepA protein OMPdecase PF00215.19 ESL06440.1 - 5.3e-37 127.4 0.0 7.6e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.22 ESL06440.1 - 3.9e-16 58.8 2.5 1.2e-15 57.3 1.7 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.1 ESL06440.1 - 0.00074 18.8 0.0 0.0015 17.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.1 ESL06440.1 - 0.0015 17.7 0.0 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase BRX PF08381.6 ESL06440.1 - 0.018 14.1 0.0 0.046 12.7 0.0 1.6 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 DXP_synthase_N PF13292.1 ESL06440.1 - 0.054 12.4 0.1 0.078 11.8 0.1 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Whirly PF08536.6 ESL06440.1 - 0.065 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Whirly transcription factor Phage_Coat_Gp8 PF05371.7 ESL06440.1 - 0.13 11.8 2.7 0.14 11.7 0.4 2.2 3 0 0 3 3 3 0 Phage major coat protein, Gp8 OSCP PF00213.13 ESL06441.1 - 7.7e-09 35.6 0.3 2.2e-08 34.1 0.2 1.7 1 1 0 1 1 1 1 ATP synthase delta (OSCP) subunit Corona_NS4 PF03905.8 ESL06441.1 - 0.12 12.2 0.2 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Coronavirus non-structural protein NS4 cNMP_binding PF00027.24 ESL06442.1 - 2.4e-25 88.1 0.1 1.5e-13 50.3 0.0 4.0 3 1 0 3 3 3 3 Cyclic nucleotide-binding domain DUF2408 PF10303.4 ESL06443.1 - 0.002 18.2 0.9 0.0025 17.9 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) BicD PF09730.4 ESL06443.1 - 0.0047 15.3 1.9 0.0047 15.3 1.3 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Mnd1 PF03962.10 ESL06443.1 - 0.0053 16.4 3.1 0.0061 16.2 2.2 1.1 1 0 0 1 1 1 1 Mnd1 family HOOK PF05622.7 ESL06443.1 - 0.0075 14.1 1.4 0.0079 14.0 1.0 1.1 1 0 0 1 1 1 1 HOOK protein CorA PF01544.13 ESL06443.1 - 0.011 14.8 2.4 0.013 14.5 1.7 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Rab5-bind PF09311.6 ESL06443.1 - 0.012 15.5 4.4 0.014 15.3 3.0 1.2 1 0 0 1 1 1 0 Rabaptin-like protein DUF1395 PF07160.7 ESL06443.1 - 0.012 15.0 0.4 0.024 14.1 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1395) APG6 PF04111.7 ESL06443.1 - 0.015 14.3 4.8 0.017 14.2 3.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Bacillus_HBL PF05791.6 ESL06443.1 - 0.018 14.3 0.4 0.021 14.1 0.3 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) GAS PF13851.1 ESL06443.1 - 0.021 14.0 3.7 0.024 13.8 2.6 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 ESL06443.1 - 0.024 13.8 0.7 0.029 13.5 0.5 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CCDC144C PF14915.1 ESL06443.1 - 0.025 13.5 6.6 0.071 12.0 4.6 1.6 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region DUF3584 PF12128.3 ESL06443.1 - 0.054 10.8 3.4 0.055 10.8 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TFR_dimer PF04253.10 ESL06443.1 - 0.056 13.0 0.5 0.071 12.6 0.3 1.4 1 1 0 1 1 1 0 Transferrin receptor-like dimerisation domain MCC-bdg_PDZ PF10506.4 ESL06443.1 - 0.056 13.2 2.7 0.36 10.7 0.2 2.6 1 1 2 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF342 PF03961.8 ESL06443.1 - 0.059 11.7 4.8 0.11 10.8 3.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) PEPcase PF00311.12 ESL06443.1 - 0.06 11.1 1.6 0.071 10.9 1.1 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Seryl_tRNA_N PF02403.17 ESL06443.1 - 0.061 13.3 8.0 0.11 12.5 5.3 1.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AAA_13 PF13166.1 ESL06443.1 - 0.07 11.5 2.0 0.077 11.4 1.4 1.0 1 0 0 1 1 1 0 AAA domain Apolipoprotein PF01442.13 ESL06443.1 - 0.07 12.6 6.1 0.12 11.8 4.2 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain ADIP PF11559.3 ESL06443.1 - 0.07 13.0 4.3 0.083 12.7 3.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF3422 PF11902.3 ESL06443.1 - 0.07 11.9 1.9 0.086 11.7 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) ERM PF00769.14 ESL06443.1 - 0.076 12.5 6.3 0.081 12.4 4.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family HAUS-augmin3 PF14932.1 ESL06443.1 - 0.087 12.0 2.4 0.099 11.8 1.7 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 FTCD_C PF04961.7 ESL06443.1 - 0.098 12.0 0.9 0.12 11.7 0.6 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase YkuI_C PF10388.4 ESL06443.1 - 0.1 12.2 0.8 0.13 11.9 0.5 1.1 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain RasGAP_C PF03836.10 ESL06443.1 - 0.11 12.1 2.5 0.15 11.7 1.5 1.4 1 1 0 1 1 1 0 RasGAP C-terminus DUF4062 PF13271.1 ESL06443.1 - 0.12 12.4 1.2 3.6 7.6 0.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4062) Baculo_PEP_C PF04513.7 ESL06443.1 - 0.12 12.1 1.5 0.16 11.7 1.0 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4140 PF13600.1 ESL06443.1 - 0.13 12.6 8.0 0.075 13.4 3.7 1.8 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) FimP PF09766.4 ESL06443.1 - 0.19 10.7 1.9 0.26 10.3 1.3 1.1 1 0 0 1 1 1 0 Fms-interacting protein KR PF08659.5 ESL06443.1 - 0.2 11.3 1.4 0.35 10.5 1.0 1.5 1 1 0 1 1 1 0 KR domain Herpes_U30 PF04523.8 ESL06443.1 - 0.2 9.0 1.6 0.23 8.8 1.1 1.0 1 0 0 1 1 1 0 Herpes virus tegument protein U30 DUF148 PF02520.12 ESL06443.1 - 0.21 11.3 2.5 0.36 10.6 1.7 1.5 1 1 0 1 1 1 0 Domain of unknown function DUF148 Cauli_AT PF03233.8 ESL06443.1 - 0.21 11.2 2.1 0.32 10.7 1.1 1.4 1 1 0 1 1 1 0 Aphid transmission protein V_ATPase_I PF01496.14 ESL06443.1 - 0.32 8.8 1.8 0.35 8.6 1.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF972 PF06156.8 ESL06443.1 - 0.35 11.2 4.6 0.45 10.8 3.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 ESL06443.1 - 0.36 10.4 9.1 2 7.9 1.6 1.9 1 1 1 2 2 2 0 IncA protein HisKA_3 PF07730.8 ESL06443.1 - 0.41 11.0 5.3 0.28 11.5 0.6 2.1 1 1 1 2 2 2 0 Histidine kinase COG2 PF06148.6 ESL06443.1 - 0.48 10.2 6.7 2.2 8.1 0.7 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3086 PF11285.3 ESL06443.1 - 0.62 8.8 4.5 1.9 7.2 3.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3086) Spc24 PF08286.6 ESL06443.1 - 1.2 8.8 5.9 3.7 7.2 3.9 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Vps51 PF08700.6 ESL06443.1 - 1.2 8.9 4.7 4 7.3 2.0 2.3 1 1 1 2 2 2 0 Vps51/Vps67 Atg14 PF10186.4 ESL06443.1 - 1.5 7.7 5.4 1.6 7.5 3.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FlgN PF05130.7 ESL06443.1 - 1.6 8.9 7.8 5.7 7.1 5.6 1.7 1 1 0 1 1 1 0 FlgN protein Spc7 PF08317.6 ESL06443.1 - 1.7 7.2 6.9 2.2 6.8 4.1 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.10 ESL06443.1 - 2.8 7.4 7.9 8.6 5.9 0.9 2.2 1 1 1 2 2 2 0 Septum formation initiator FadA PF09403.5 ESL06443.1 - 3 7.8 8.3 17 5.4 1.7 2.0 1 1 1 2 2 2 0 Adhesion protein FadA PUF PF00806.14 ESL06444.1 - 1.8e-44 146.7 4.9 2.1e-06 26.8 0.1 7.3 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat DUF3231 PF11553.3 ESL06444.1 - 0.07 12.6 0.2 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) eIF-4B PF06273.6 ESL06444.1 - 0.31 9.7 4.9 0.47 9.1 3.4 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B DUF2763 PF10961.3 ESL06444.1 - 1.5 9.3 8.5 1.9 8.9 5.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) zf-C3HC4_3 PF13920.1 ESL06445.1 - 4.8e-11 42.1 10.6 1e-10 41.1 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Plus-3 PF03126.13 ESL06445.1 - 1.7e-07 31.2 0.0 3.3e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Plus-3 domain zf-C3HC4_2 PF13923.1 ESL06445.1 - 0.0053 16.7 13.3 0.013 15.5 9.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL06445.1 - 0.036 13.9 12.5 0.095 12.5 8.6 1.8 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.1 ESL06445.1 - 0.41 10.2 6.5 1.7 8.2 3.8 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.1 ESL06445.1 - 0.65 9.7 10.3 1.5 8.6 7.2 1.7 1 0 0 1 1 1 0 zinc-RING finger domain RabGAP-TBC PF00566.13 ESL06448.1 - 1.5e-35 122.6 1.1 3.2e-34 118.2 0.2 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Mito_carr PF00153.22 ESL06449.1 - 6.1e-42 141.2 1.1 7.4e-14 51.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PUF PF00806.14 ESL06450.1 - 4.2e-06 25.9 0.0 0.0088 15.4 0.0 2.2 2 0 0 2 2 2 2 Pumilio-family RNA binding repeat Radical_SAM PF04055.16 ESL06451.1 - 1.9e-20 73.6 0.3 4.5e-20 72.4 0.2 1.7 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.15 ESL06451.1 - 9.2e-20 70.3 0.0 2e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.15 ESL06451.1 - 6.5e-05 22.6 0.1 0.00011 21.8 0.1 1.4 1 0 0 1 1 1 1 TRAM domain Peptidase_M28 PF04389.12 ESL06452.1 - 2e-22 79.8 1.4 1.2e-06 28.4 0.0 3.2 3 0 0 3 3 3 3 Peptidase family M28 Hemerythrin PF01814.18 ESL06454.1 - 0.14 12.3 0.9 0.44 10.6 0.3 2.1 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain AMP-binding PF00501.23 ESL06455.1 - 2.2e-34 118.5 0.2 2.9e-34 118.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Zip PF02535.17 ESL06457.1 - 3.5e-30 105.1 17.5 5.1e-30 104.5 12.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter 2OG-FeII_Oxy_2 PF13532.1 ESL06458.1 - 9.5e-50 169.1 0.0 1.2e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2039 PF10217.4 ESL06460.1 - 6e-26 90.2 16.3 1.1e-25 89.5 11.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) DUF2797 PF10977.3 ESL06460.1 - 0.073 12.6 5.3 0.13 11.8 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) HMG_box PF00505.14 ESL06461.1 - 0.12 12.6 4.5 0.13 12.5 0.0 3.0 2 1 0 2 2 2 0 HMG (high mobility group) box DUF1525 PF07511.6 ESL06461.1 - 0.87 9.5 4.1 1.2 9.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) DUF3106 PF11304.3 ESL06461.1 - 1.4 9.3 12.3 1.8 8.9 6.5 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) RusA PF05866.6 ESL06461.1 - 3.2 8.1 10.6 1.9 8.9 1.5 2.3 1 1 1 2 2 2 0 Endodeoxyribonuclease RusA WD40 PF00400.27 ESL06463.1 - 3.2e-64 210.6 20.9 2.7e-12 46.0 0.3 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 ESL06463.1 - 0.00013 21.7 0.0 0.0018 17.9 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A zf-UBP PF02148.14 ESL06464.1 - 9.1e-11 41.7 9.7 9.1e-11 41.7 6.7 2.4 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 ESL06464.1 - 6e-09 35.5 8.2 6e-09 35.5 5.7 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL06464.1 - 7.7e-07 29.0 8.4 7.7e-07 29.0 5.8 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESL06464.1 - 1.2e-05 25.2 4.4 1.2e-05 25.2 3.1 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 ESL06464.1 - 1.8e-05 24.3 7.5 1.8e-05 24.3 5.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESL06464.1 - 3.9e-05 23.3 2.8 0.00012 21.7 1.9 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 ESL06464.1 - 0.00021 20.8 7.9 0.00021 20.8 5.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 ESL06464.1 - 0.028 14.0 3.2 0.077 12.5 2.2 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Exo_endo_phos PF03372.18 ESL06465.1 - 3.2e-23 82.9 0.1 4.8e-23 82.3 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESL06465.1 - 0.0013 18.2 0.0 0.0073 15.9 0.0 2.3 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase DnaJ PF00226.26 ESL06467.1 - 1.6e-21 75.8 0.4 3.6e-21 74.6 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESL06467.1 - 2.3e-12 46.6 0.0 4.5e-06 26.0 0.1 2.5 1 1 1 2 2 2 2 X-domain of DnaJ-containing DUF4379 PF14311.1 ESL06469.1 - 1.8e-20 72.4 7.4 5e-15 55.0 2.4 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4379) NAD_binding_10 PF13460.1 ESL06470.1 - 1.6e-10 41.3 0.0 7.2e-05 22.8 0.0 2.3 1 1 1 2 2 2 2 NADH(P)-binding Epimerase PF01370.16 ESL06470.1 - 1.4e-07 31.2 0.0 2.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 ESL06470.1 - 0.00036 19.5 0.0 0.018 13.9 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.20 ESL06470.1 - 0.025 14.4 0.0 0.074 12.9 0.0 1.9 1 1 0 1 1 1 0 short chain dehydrogenase RmlD_sub_bind PF04321.12 ESL06470.1 - 0.092 11.6 0.0 0.27 10.0 0.0 1.8 1 1 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.8 ESL06470.1 - 0.18 11.0 0.1 0.47 9.6 0.0 1.7 2 0 0 2 2 2 0 NmrA-like family ATP-synt_C PF00137.16 ESL06471.1 - 1.9e-17 62.8 12.0 2.7e-17 62.4 8.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit C Peptidase_M14 PF00246.19 ESL06472.1 - 1.2e-26 93.9 0.0 2e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESL06472.1 - 9.6e-05 21.3 0.0 0.00016 20.6 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Nucleotid_trans PF03407.11 ESL06474.1 - 8e-50 169.5 0.1 1.1e-49 169.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Kinesin PF00225.18 ESL06476.1 - 9.5e-100 333.5 0.0 1.7e-99 332.7 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain GETHR PF05671.6 ESL06477.1 - 0.042 12.9 5.2 0.092 11.9 3.6 1.5 1 0 0 1 1 1 0 GETHR pentapeptide repeat (5 copies) Cation_efflux PF01545.16 ESL06478.1 - 1.1e-31 110.0 0.1 1.3e-31 109.7 0.1 1.0 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ESL06478.1 - 0.0047 15.9 7.9 0.011 14.7 5.5 1.6 1 1 1 2 2 2 1 ZIP Zinc transporter Clp1 PF06807.9 ESL06478.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 Med9 PF07544.8 ESL06479.1 - 0.43 10.3 4.0 0.97 9.2 2.8 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 zf-CCHC_2 PF13696.1 ESL06480.1 - 0.00036 19.9 0.3 0.0014 18.0 0.2 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.1 ESL06480.1 - 0.00064 19.1 0.4 0.00064 19.1 0.3 2.9 4 0 0 4 4 4 1 GAG-polyprotein viral zinc-finger zf-C2H2_jaz PF12171.3 ESL06480.1 - 0.015 15.4 1.5 0.033 14.3 1.0 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding NUFIP1 PF10453.4 ESL06480.1 - 0.082 12.4 0.3 0.32 10.5 0.0 2.1 2 0 0 2 2 2 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Zn-ribbon_8 PF09723.5 ESL06480.1 - 6.9 6.7 8.7 34 4.5 0.1 2.7 2 0 0 2 2 2 0 Zinc ribbon domain dCMP_cyt_deam_1 PF00383.17 ESL06481.1 - 3.6e-12 45.8 0.7 5.2e-12 45.2 0.5 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 ESL06481.1 - 1.8e-07 31.2 0.1 0.00012 22.0 0.0 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region XFP PF03894.10 ESL06481.1 - 0.024 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase LmjF365940-deam PF14421.1 ESL06481.1 - 0.058 12.7 0.6 0.12 11.7 0.4 1.4 1 1 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases Fer2_4 PF13510.1 ESL06481.1 - 0.25 11.1 1.4 5.9 6.7 0.3 2.2 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Aminotran_1_2 PF00155.16 ESL06482.1 - 1.2e-68 231.6 0.0 1.4e-68 231.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PX PF00787.19 ESL06483.1 - 2.4e-20 72.4 0.0 1.6e-10 40.7 0.0 2.7 2 0 0 2 2 2 2 PX domain DUF4476 PF14771.1 ESL06483.1 - 0.057 13.4 0.0 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) ADIP PF11559.3 ESL06484.1 - 0.0003 20.7 0.7 0.00034 20.5 0.5 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding HALZ PF02183.13 ESL06484.1 - 0.0084 15.7 4.3 0.059 13.0 0.1 2.7 2 1 1 3 3 3 1 Homeobox associated leucine zipper HlyD PF00529.15 ESL06484.1 - 0.021 14.1 5.5 0.028 13.7 3.8 1.2 1 0 0 1 1 1 0 HlyD family secretion protein TMF_DNA_bd PF12329.3 ESL06484.1 - 0.037 13.8 2.1 0.057 13.2 1.4 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CCDC155 PF14662.1 ESL06484.1 - 0.049 13.2 1.8 0.066 12.8 1.3 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 Taxilin PF09728.4 ESL06484.1 - 0.065 12.3 0.5 0.079 12.0 0.4 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Scaffolding_pro PF11418.3 ESL06484.1 - 0.071 13.4 0.5 0.18 12.1 0.3 1.6 1 1 1 2 2 2 0 Phi29 scaffolding protein ATG_C PF09333.6 ESL06484.1 - 0.13 12.4 0.9 1 9.5 0.1 2.2 1 1 0 2 2 2 0 ATG C terminal domain E2R135 PF11570.3 ESL06484.1 - 1.2 9.2 7.2 2 8.5 1.3 2.2 1 1 1 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 Complex1_LYR PF05347.10 ESL06485.1 - 0.0098 15.6 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) tRNA-synt_2b PF00587.20 ESL06486.1 - 6.9e-31 107.1 0.0 9.8e-31 106.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) PDEase_I PF00233.14 ESL06487.1 - 1.1e-11 44.9 0.1 3.2e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase IncA PF04156.9 ESL06487.1 - 0.0015 18.1 2.0 0.0015 18.1 1.4 3.4 3 0 0 3 3 3 2 IncA protein DUF948 PF06103.6 ESL06487.1 - 0.051 13.4 0.8 0.47 10.3 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.10 ESL06487.1 - 0.4 10.3 2.1 1.3 8.6 1.1 2.0 2 0 0 2 2 2 0 Sec34-like family DUF4446 PF14584.1 ESL06487.1 - 1.1 9.0 3.8 8.4 6.2 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) TMF_DNA_bd PF12329.3 ESL06487.1 - 1.8 8.4 22.2 1.3 8.8 6.9 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding APG6 PF04111.7 ESL06487.1 - 5.9 5.8 15.1 0.32 9.9 1.9 2.4 2 0 0 2 2 2 0 Autophagy protein Apg6 MORN PF02493.15 ESL06488.1 - 3.1e-35 117.7 50.8 7.5e-06 25.3 0.0 10.8 11 1 0 11 11 11 10 MORN repeat PH PF00169.24 ESL06488.1 - 9.8e-06 25.7 0.1 1.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Spc7 PF08317.6 ESL06490.1 - 8.4e-05 21.3 1.3 0.00017 20.3 0.9 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Tropomyosin PF00261.15 ESL06490.1 - 9.9e-05 21.5 4.5 9.9e-05 21.5 3.1 2.2 3 1 0 3 3 3 1 Tropomyosin TMF_DNA_bd PF12329.3 ESL06490.1 - 0.0046 16.7 4.2 0.0046 16.7 2.9 2.8 2 1 1 3 3 3 1 TATA element modulatory factor 1 DNA binding Orthopox_A5L PF06193.6 ESL06490.1 - 0.013 15.4 0.1 0.031 14.2 0.0 1.7 2 0 0 2 2 2 0 Orthopoxvirus A5L protein-like UPF0240 PF06784.6 ESL06490.1 - 0.021 14.4 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) Herpes_U30 PF04523.8 ESL06490.1 - 0.071 10.5 1.6 0.042 11.3 0.1 1.4 2 0 0 2 2 2 0 Herpes virus tegument protein U30 Dak2 PF02734.12 ESL06490.1 - 0.071 12.7 1.4 0.59 9.7 0.1 2.3 1 1 1 2 2 2 0 DAK2 domain Tropomyosin_1 PF12718.2 ESL06490.1 - 0.13 12.1 10.6 1.6 8.5 6.8 2.4 1 1 1 2 2 2 0 Tropomyosin like TFIIA PF03153.8 ESL06490.1 - 0.13 12.1 1.2 0.16 11.8 0.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fib_alpha PF08702.5 ESL06490.1 - 0.15 12.1 1.6 0.2 11.7 0.2 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF607 PF04678.8 ESL06490.1 - 0.17 11.7 4.5 0.27 11.1 2.7 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF607 DUF342 PF03961.8 ESL06490.1 - 0.21 9.9 3.0 0.3 9.4 2.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Vps5 PF09325.5 ESL06490.1 - 0.21 10.8 6.0 0.26 10.5 3.3 1.8 2 0 0 2 2 2 0 Vps5 C terminal like Med30 PF11315.3 ESL06490.1 - 0.38 10.8 4.6 2 8.5 3.6 1.7 1 1 1 2 2 2 0 Mediator complex subunit 30 KIAA1430 PF13879.1 ESL06490.1 - 0.4 11.1 7.1 0.19 12.1 2.2 2.2 2 0 0 2 2 2 0 KIAA1430 homologue Caps_synth_GfcC PF06251.6 ESL06490.1 - 0.43 9.7 3.7 0.84 8.7 2.6 1.4 1 0 0 1 1 1 0 Capsule biosynthesis GfcC YlqD PF11068.3 ESL06490.1 - 0.77 9.7 11.1 0.57 10.2 4.5 2.4 2 1 0 2 2 2 0 YlqD protein OmpH PF03938.9 ESL06490.1 - 0.78 9.6 8.7 1.9 8.3 6.0 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TBPIP PF07106.8 ESL06490.1 - 0.95 8.9 8.4 0.3 10.6 3.2 2.1 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Bap31 PF05529.7 ESL06490.1 - 0.96 8.8 4.3 2.1 7.7 3.0 1.6 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Lge1 PF11488.3 ESL06490.1 - 1.1 9.5 5.0 25 5.1 0.0 3.1 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 DUF4446 PF14584.1 ESL06490.1 - 1.9 8.2 7.4 10 5.9 1.0 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF4446) UPF0242 PF06785.6 ESL06490.1 - 2.3 6.8 7.2 0.55 8.8 2.1 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) Med9 PF07544.8 ESL06490.1 - 4.7 7.0 9.8 40 4.0 6.8 2.4 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 UCH PF00443.24 ESL06491.1 - 8.8e-46 156.1 0.0 1.5e-45 155.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL06491.1 - 5.5e-22 78.5 0.0 1.9e-21 76.7 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-RanBP PF00641.13 ESL06491.1 - 0.058 12.5 6.0 0.013 14.6 0.8 2.5 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others NTR2 PF15458.1 ESL06491.1 - 0.14 11.4 3.9 0.095 11.9 0.8 1.9 1 1 1 2 2 2 0 Nineteen complex-related protein 2 FtsX PF02687.16 ESL06492.1 - 8.6e-24 83.6 70.2 8.7e-16 57.7 7.6 5.3 5 0 0 5 5 5 3 FtsX-like permease family DUF3186 PF11382.3 ESL06492.1 - 2.2 7.3 7.2 0.24 10.4 1.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3186) TMEMspv1-c74-12 PF11044.3 ESL06492.1 - 5.5 6.6 8.7 40 3.8 6.0 2.6 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein LCAT PF02450.10 ESL06493.1 - 1.2e-50 172.6 0.0 1.2e-48 166.0 0.0 2.1 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 ESL06493.1 - 0.019 14.8 0.2 0.036 13.9 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family LRR_4 PF12799.2 ESL06494.1 - 2.9e-15 55.4 0.3 2.5e-08 33.3 0.1 3.2 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL06494.1 - 1.9e-07 30.7 0.1 3.3e-06 26.7 0.0 2.6 3 0 0 3 3 3 1 Leucine rich repeat LRR_9 PF14580.1 ESL06494.1 - 1.9e-07 30.8 0.1 5.1e-07 29.4 0.0 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_7 PF13504.1 ESL06494.1 - 0.00011 21.8 1.1 3.1 8.4 0.0 5.0 5 0 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 ESL06494.1 - 0.031 14.2 0.4 4 7.8 0.0 3.5 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.1 ESL06494.1 - 0.076 13.1 0.6 3.5 7.9 0.0 3.6 5 0 0 5 5 5 0 Leucine Rich repeat ubiquitin PF00240.18 ESL06495.1 - 0.0016 17.7 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family EF-hand_5 PF13202.1 ESL06496.1 - 9.9e-09 34.1 0.5 0.00073 18.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 ESL06496.1 - 1.4e-07 30.3 1.1 0.011 14.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 ESL06496.1 - 8.3e-07 28.3 1.1 0.044 13.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 ESL06496.1 - 0.00015 21.8 1.4 0.0049 16.9 1.0 2.5 1 1 0 1 1 1 1 EF-hand domain pair Dockerin_1 PF00404.13 ESL06496.1 - 0.00094 18.7 1.8 0.26 11.0 0.0 2.6 2 0 0 2 2 2 2 Dockerin type I repeat EF-hand_8 PF13833.1 ESL06496.1 - 0.0011 18.4 0.6 0.46 10.1 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair FUN14 PF04930.10 ESL06496.1 - 0.1 12.8 0.8 0.21 11.9 0.6 1.6 1 1 0 1 1 1 0 FUN14 family Ribonuc_2-5A PF06479.7 ESL06497.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease 2-5A RNase_H_2 PF13482.1 ESL06497.1 - 0.16 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 RNase_H superfamily RRM_1 PF00076.17 ESL06498.1 - 3.2e-30 103.5 0.0 3.4e-09 36.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06498.1 - 6e-24 83.8 0.1 2.2e-09 37.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06498.1 - 2.1e-20 72.3 0.1 2.8e-07 30.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESL06498.1 - 0.0022 17.6 0.6 0.37 10.6 0.0 2.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 ESL06498.1 - 0.0083 15.9 0.0 1.5 8.7 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif RNA_bind PF08675.6 ESL06498.1 - 0.0092 15.9 0.0 0.61 10.1 0.0 2.8 3 0 0 3 3 3 1 RNA binding domain Ribonuclease_3 PF00636.21 ESL06499.1 - 0.14 12.6 0.0 1.3 9.4 0.0 2.5 2 1 0 2 2 2 0 Ribonuclease III domain Glyco_transf_22 PF03901.12 ESL06500.1 - 4.1e-29 101.8 21.2 8.3e-29 100.8 14.7 1.5 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family APG6 PF04111.7 ESL06503.1 - 0.066 12.2 5.8 0.11 11.5 4.0 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Hemerythrin PF01814.18 ESL06503.1 - 0.11 12.6 4.0 0.19 11.8 2.8 1.3 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain Spc7 PF08317.6 ESL06503.1 - 0.18 10.4 6.2 0.26 9.9 4.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein YlqD PF11068.3 ESL06503.1 - 0.21 11.6 4.7 0.096 12.7 1.1 1.8 1 1 1 2 2 2 0 YlqD protein V_ATPase_I PF01496.14 ESL06503.1 - 0.56 7.9 2.1 0.67 7.7 1.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 ESL06503.1 - 2 7.9 16.3 3.1 7.3 8.5 2.1 1 1 1 2 2 2 0 IncA protein FHA PF00498.21 ESL06505.1 - 2.8e-12 46.5 0.1 5.6e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 FHA domain zf-C3HC4 PF00097.20 ESL06505.1 - 8.5e-07 28.5 8.2 8.5e-07 28.5 5.7 4.2 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL06505.1 - 2.7e-05 23.7 9.1 2.7e-05 23.7 6.3 3.8 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESL06505.1 - 5.7e-05 23.0 11.8 5.7e-05 23.0 8.2 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL06505.1 - 0.00022 20.9 10.5 0.00022 20.9 7.3 4.4 3 2 0 3 3 3 1 Ring finger domain zf-RING_6 PF14835.1 ESL06505.1 - 0.0049 16.6 7.6 0.0049 16.6 5.3 2.8 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 ESL06505.1 - 0.021 14.5 7.3 0.075 12.7 5.0 2.0 1 0 0 1 1 1 0 RING-type zinc-finger IMPDH PF00478.20 ESL06509.1 - 1.3e-133 445.3 1.6 1.4e-133 445.1 1.1 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 ESL06509.1 - 1.4e-12 47.1 0.1 2.8e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 ESL06509.1 - 9.8e-11 41.0 1.2 9.8e-11 41.0 0.1 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.10 ESL06509.1 - 2e-10 40.3 1.8 3.5e-06 26.3 0.1 2.4 3 0 0 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.16 ESL06509.1 - 0.00017 20.8 0.1 0.048 12.9 0.0 2.5 2 1 1 3 3 3 2 Histidine biosynthesis protein Glu_synthase PF01645.12 ESL06509.1 - 0.0035 16.3 1.1 0.0061 15.5 0.8 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase Aldolase PF01081.14 ESL06509.1 - 0.024 13.8 0.1 0.063 12.4 0.1 1.6 1 0 0 1 1 1 0 KDPG and KHG aldolase NanE PF04131.9 ESL06509.1 - 0.034 13.1 0.1 0.082 11.8 0.1 1.7 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Skp1 PF01466.14 ESL06510.1 - 8.9e-34 115.3 0.9 8.9e-34 115.3 0.6 1.5 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 ESL06510.1 - 9.6e-13 48.0 0.0 3.4e-12 46.2 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF1981 PF09324.5 ESL06511.1 - 0.028 13.9 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) RIB43A PF05914.7 ESL06512.1 - 5.8e-100 334.5 63.7 7e-100 334.2 44.1 1.0 1 0 0 1 1 1 1 RIB43A DUF563 PF04577.9 ESL06514.1 - 7.6e-18 65.1 0.4 1.2e-17 64.5 0.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF563) RPA_C PF08784.6 ESL06515.1 - 1.6e-19 70.2 0.1 3.2e-19 69.2 0.1 1.5 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 ESL06515.1 - 8.2e-08 31.9 0.1 1.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain GntR PF00392.16 ESL06515.1 - 0.014 14.8 0.0 0.053 12.9 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Peptidase_C39 PF03412.10 ESL06515.1 - 0.045 13.5 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase C39 family Tubulin PF00091.20 ESL06516.1 - 1.2e-71 241.0 0.0 1.9e-71 240.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESL06516.1 - 5.1e-40 136.4 0.0 7.6e-40 135.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESL06516.1 - 2.7e-05 24.1 0.0 5.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESL06516.1 - 0.0015 18.0 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.1 ESL06516.1 - 0.19 10.6 0.2 0.49 9.2 0.0 1.7 2 0 0 2 2 2 0 Tubulin like RNase_PH PF01138.16 ESL06517.1 - 7.9e-28 97.3 0.7 1.1e-27 96.9 0.5 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 TBPIP PF07106.8 ESL06519.1 - 0.0031 17.0 12.9 0.022 14.2 1.3 3.7 3 0 0 3 3 3 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HalX PF08663.5 ESL06519.1 - 0.027 14.4 8.7 0.03 14.2 2.1 3.6 2 1 1 3 3 3 0 HalX domain DUF604 PF04646.7 ESL06519.1 - 0.045 12.9 0.0 0.12 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF604 DivIC PF04977.10 ESL06519.1 - 6.5 6.3 11.0 5.8 6.4 0.3 3.6 3 0 0 3 3 3 0 Septum formation initiator AA_permease_2 PF13520.1 ESL06520.1 - 5e-30 104.3 26.4 5.9e-30 104.1 18.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESL06520.1 - 6.6e-14 51.1 18.0 8.3e-14 50.7 12.5 1.2 1 0 0 1 1 1 1 Amino acid permease CorA PF01544.13 ESL06521.1 - 0.00077 18.5 2.2 0.0092 15.0 1.9 2.4 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF4650 PF15509.1 ESL06521.1 - 0.1 11.5 0.1 0.16 10.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) Myotub-related PF06602.9 ESL06522.1 - 5.1e-90 301.7 0.0 7.6e-90 301.2 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.15 ESL06522.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 ESL06522.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family FYVE PF01363.16 ESL06522.1 - 1 9.2 20.0 0.021 14.7 8.4 2.3 2 0 0 2 2 2 0 FYVE zinc finger Grp1_Fun34_YaaH PF01184.14 ESL06523.1 - 3.6e-43 147.3 8.3 4.9e-43 146.8 5.7 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3784 PF12650.2 ESL06523.1 - 5.8 6.9 10.3 1.6 8.7 2.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3784) V-ATPase_G PF03179.10 ESL06525.1 - 1.9e-18 66.6 15.8 2e-18 66.5 10.9 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit MalF_P2 PF14785.1 ESL06525.1 - 0.031 14.1 6.1 0.037 13.9 4.2 1.1 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain CFTR_R PF14396.1 ESL06525.1 - 0.096 12.0 1.5 0.14 11.5 1.1 1.2 1 1 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain DUF3154 PF11351.3 ESL06525.1 - 0.24 11.1 8.1 0.088 12.5 3.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3154) AIF-MLS PF14962.1 ESL06525.1 - 0.27 10.8 3.7 0.32 10.6 2.6 1.1 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Drf_GBD PF06371.8 ESL06525.1 - 0.64 9.3 4.6 0.8 9.0 3.2 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain DUF2072 PF09845.4 ESL06525.1 - 0.75 9.7 3.6 0.86 9.5 2.5 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) vATP-synt_E PF01991.13 ESL06525.1 - 1 8.6 17.7 2.9 7.1 12.3 1.7 1 1 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Pinin_SDK_memA PF04696.8 ESL06525.1 - 1.1 8.8 10.6 1.4 8.5 7.4 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region APG6 PF04111.7 ESL06525.1 - 9.1 5.2 12.0 11 4.9 8.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 ATP-synt_B PF00430.13 ESL06525.1 - 10 5.9 19.8 3.7 7.3 11.7 1.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Pkinase PF00069.20 ESL06526.1 - 1e-38 132.9 0.1 2.1e-33 115.5 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06526.1 - 1.8e-16 59.9 0.0 4.3e-16 58.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06526.1 - 0.0015 17.5 0.0 0.0032 16.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF4599 PF15371.1 ESL06526.1 - 0.0089 16.0 0.1 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4599) Racemase_4 PF13615.1 ESL06527.1 - 1.4e-20 73.4 0.1 3.3e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 Putative alanine racemase MCM_bind PF09739.4 ESL06527.1 - 1.1e-11 44.2 0.0 3.4e-11 42.7 0.0 1.7 1 1 0 1 1 1 1 Mini-chromosome maintenance replisome factor STAS_2 PF13466.1 ESL06527.1 - 0.011 15.7 0.9 0.63 10.1 0.2 2.6 2 0 0 2 2 2 0 STAS domain AAA_16 PF13191.1 ESL06528.1 - 0.0003 20.8 0.4 0.0017 18.3 0.3 2.1 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 ESL06528.1 - 0.00056 19.6 0.0 0.53 9.9 0.0 2.5 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 ESL06528.1 - 0.014 14.2 0.0 0.024 13.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF258 PF03193.11 ESL06528.1 - 0.028 13.5 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_14 PF13173.1 ESL06528.1 - 0.033 14.0 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL06528.1 - 0.091 12.1 0.0 0.23 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESL06528.1 - 0.1 12.3 0.0 0.39 10.5 0.0 2.0 1 0 0 1 1 1 0 Part of AAA domain Arch_ATPase PF01637.13 ESL06528.1 - 0.2 11.2 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase 3HCDH PF00725.17 ESL06529.1 - 0.0079 16.5 0.0 0.026 14.9 0.0 1.9 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DUF4194 PF13835.1 ESL06530.1 - 0.15 11.4 0.1 0.26 10.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) Mito_carr PF00153.22 ESL06532.1 - 2.3e-13 49.6 0.2 5.2e-09 35.6 0.1 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Pkinase PF00069.20 ESL06533.1 - 2.5e-26 92.3 0.0 4e-21 75.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06533.1 - 5.4e-08 32.2 0.0 0.014 14.4 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Kdo PF06293.9 ESL06533.1 - 0.00092 18.3 0.1 0.0019 17.2 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NosD PF05048.8 ESL06534.1 - 0.022 13.9 8.0 14 4.7 0.6 4.3 3 1 1 4 4 4 0 Periplasmic copper-binding protein (NosD) PS_Dcarbxylase PF02666.10 ESL06535.1 - 2e-30 105.6 0.0 2.4e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase BORA_N PF15280.1 ESL06537.1 - 0.0059 15.9 0.4 0.0059 15.9 0.3 2.2 2 0 0 2 2 2 1 Protein aurora borealis N-terminus EF-hand_like PF09279.6 ESL06537.1 - 0.15 12.0 0.9 6.7 6.8 0.7 2.4 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like Pkinase PF00069.20 ESL06539.1 - 1.5e-61 207.8 0.0 2.1e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06539.1 - 5.3e-32 110.9 0.0 7.8e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06539.1 - 0.00035 19.6 0.0 0.00062 18.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL06539.1 - 0.0042 16.8 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL06539.1 - 0.05 12.6 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NAS PF03059.11 ESL06540.1 - 0.029 13.5 0.8 2.2 7.3 0.0 2.7 3 0 0 3 3 3 0 Nicotianamine synthase protein DGF-1_C PF11040.3 ESL06541.1 - 2e-22 78.8 0.3 3.7e-22 77.9 0.2 1.5 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4227 PF14004.1 ESL06541.1 - 0.0021 17.8 0.2 0.0064 16.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4227) SHR3_chaperone PF08229.6 ESL06541.1 - 0.013 14.5 0.5 0.017 14.0 0.3 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 DUF1183 PF06682.7 ESL06541.1 - 0.1 12.1 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) SID-1_RNA_chan PF13965.1 ESL06541.1 - 8.2 4.4 11.8 16 3.5 8.2 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Glyco_transf_25 PF01755.12 ESL06542.1 - 6.2e-16 58.6 0.0 2.7e-13 50.0 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) IU_nuc_hydro PF01156.14 ESL06543.1 - 1.7e-52 178.6 0.0 1.9e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF59 PF01883.14 ESL06544.1 - 0.03 14.2 0.3 2.4 8.1 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function DUF59 Baculo_gp64 PF03273.8 ESL06545.1 - 0.17 10.0 0.4 0.3 9.1 0.3 1.4 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family SDA1 PF05285.7 ESL06546.1 - 0.0012 18.2 10.3 0.0016 17.8 7.1 1.1 1 0 0 1 1 1 1 SDA1 TFIIA PF03153.8 ESL06546.1 - 0.087 12.7 5.7 0.1 12.4 4.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 ESL06546.1 - 0.094 10.6 12.4 0.11 10.4 8.6 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 ESL06546.1 - 0.14 10.5 13.3 0.17 10.3 9.2 1.1 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESL06546.1 - 0.27 9.2 8.1 0.32 8.9 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 ESL06546.1 - 0.34 10.2 12.4 0.01 15.1 4.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) DNA_pol_phi PF04931.8 ESL06546.1 - 0.42 8.3 18.3 0.61 7.7 12.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.7 ESL06546.1 - 1.9 7.6 8.2 2.9 7.0 5.7 1.2 1 0 0 1 1 1 0 NOA36 protein eIF-3c_N PF05470.7 ESL06546.1 - 1.9 6.5 6.2 2.3 6.2 4.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus RRN3 PF05327.6 ESL06546.1 - 5 5.1 5.1 6.2 4.8 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pox_Ag35 PF03286.9 ESL06546.1 - 8.2 5.9 9.6 0.29 10.6 2.5 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PA26 PF04636.8 ESL06547.1 - 3.7e-31 108.3 0.0 1.2e-20 73.6 0.0 2.2 1 1 1 2 2 2 2 PA26 p53-induced protein (sestrin) DUF2592 PF10766.4 ESL06548.1 - 8.4 5.8 8.5 0.11 11.8 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2592) UNC-50 PF05216.8 ESL06549.1 - 6.4e-79 264.4 15.6 7.5e-79 264.1 10.8 1.0 1 0 0 1 1 1 1 UNC-50 family PIRT PF15099.1 ESL06549.1 - 0.099 11.8 5.6 0.86 8.8 3.8 2.3 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family DUF1712 PF08217.6 ESL06550.1 - 0.00012 20.5 0.0 0.00016 20.1 0.0 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) DUF1674 PF07896.7 ESL06552.1 - 8.2e-13 48.3 0.0 1.1e-12 47.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) TGS PF02824.16 ESL06553.1 - 1.4e-20 72.8 0.1 2.4e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 ESL06553.1 - 8.2e-18 64.4 0.1 2.4e-17 62.9 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL06553.1 - 2.2e-10 40.0 0.0 3.8e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESL06553.1 - 0.00058 19.7 0.4 0.027 14.3 0.0 2.4 1 1 0 2 2 2 1 Dynamin family Miro PF08477.8 ESL06553.1 - 0.00098 19.6 0.0 0.0026 18.2 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 ESL06553.1 - 0.014 15.4 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AIG1 PF04548.11 ESL06553.1 - 0.062 12.4 0.0 0.14 11.2 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Ank_2 PF12796.2 ESL06554.1 - 1.7e-23 82.7 0.2 3.9e-13 49.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESL06554.1 - 1.4e-22 78.2 0.5 9.2e-06 25.2 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 ESL06554.1 - 7.7e-21 74.0 1.3 1.3e-09 38.2 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL06554.1 - 5.7e-19 67.7 1.4 5.1e-07 29.7 0.0 3.8 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL06554.1 - 3.1e-16 57.8 0.4 0.0012 18.9 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Peptidase_S46 PF10459.4 ESL06554.1 - 0.27 9.6 5.5 0.32 9.3 3.8 1.1 1 0 0 1 1 1 0 Peptidase S46 Pkinase PF00069.20 ESL06556.1 - 3.1e-59 200.2 0.0 3.9e-59 199.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06556.1 - 2.6e-26 92.2 0.0 4e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL06556.1 - 0.0061 16.3 0.2 0.27 10.9 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL06556.1 - 0.13 11.1 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like GTP_EFTU PF00009.22 ESL06558.1 - 1.9e-26 92.6 0.2 1e-25 90.2 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL06558.1 - 7.8e-07 29.6 0.0 2.1e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESL06558.1 - 8.8e-07 28.8 0.0 2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ESL06558.1 - 0.0001 21.7 0.3 0.0011 18.4 0.2 2.6 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.17 ESL06558.1 - 0.00025 20.4 0.1 0.00055 19.3 0.0 1.6 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.18 ESL06558.1 - 0.0064 16.3 0.0 4.2 7.1 0.0 2.8 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.5 ESL06558.1 - 0.016 14.4 0.0 0.043 13.0 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit IF-2 PF11987.3 ESL06558.1 - 0.041 13.7 0.0 0.51 10.2 0.0 2.2 2 0 0 2 2 2 0 Translation-initiation factor 2 ATP_bind_1 PF03029.12 ESL06558.1 - 0.062 12.8 0.3 0.2 11.1 0.1 1.9 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.9 ESL06558.1 - 0.071 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Plasmid_RAQPRD PF09686.5 ESL06559.1 - 0.23 11.5 2.0 0.66 10.0 0.5 2.5 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Prenyltransf PF01255.14 ESL06559.1 - 0.8 8.7 8.0 0.25 10.4 2.8 2.1 2 0 0 2 2 2 0 Putative undecaprenyl diphosphate synthase Latarcin PF10279.4 ESL06559.1 - 2.7 8.2 8.6 0.26 11.5 0.1 3.3 3 2 0 3 3 3 0 Latarcin precursor TF_Zn_Ribbon PF08271.7 ESL06560.1 - 0.029 13.6 0.5 0.076 12.3 0.4 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Trm112p PF03966.11 ESL06560.1 - 0.051 13.9 0.2 0.09 13.1 0.2 1.4 1 0 0 1 1 1 0 Trm112p-like protein Unstab_antitox PF09720.5 ESL06564.1 - 0.038 13.6 0.1 0.075 12.7 0.1 1.5 1 0 0 1 1 1 0 Putative addiction module component COG5 PF10392.4 ESL06565.1 - 8.3e-12 45.2 13.7 4.2e-11 42.9 3.3 3.5 3 0 0 3 3 3 2 Golgi transport complex subunit 5 COG2 PF06148.6 ESL06565.1 - 0.0003 20.6 1.8 0.0026 17.6 1.3 2.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Sec5 PF15469.1 ESL06565.1 - 0.0034 17.1 0.5 0.033 13.9 0.2 2.4 2 0 0 2 2 2 1 Exocyst complex component Sec5 Borrelia_orfA PF02414.10 ESL06565.1 - 0.22 10.6 0.1 0.35 9.9 0.1 1.2 1 0 0 1 1 1 0 Borrelia ORF-A Vps51 PF08700.6 ESL06565.1 - 0.45 10.3 5.3 6.3 6.7 0.0 3.8 2 1 2 4 4 4 0 Vps51/Vps67 DUF2450 PF10475.4 ESL06565.1 - 0.99 8.2 8.2 0.61 8.9 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function N-terminal domain (DUF2450) AAA_12 PF13087.1 ESL06566.1 - 4.1e-63 212.3 0.0 6.6e-63 211.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain UPF1_Zn_bind PF09416.5 ESL06566.1 - 1.5e-59 199.9 3.7 2.7e-59 199.1 2.6 1.4 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_11 PF13086.1 ESL06566.1 - 2.7e-53 180.9 0.0 4.3e-53 180.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL06566.1 - 1.8e-15 56.4 2.3 9.3e-15 54.1 1.2 2.6 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 ESL06566.1 - 4.6e-13 49.1 0.1 5.7e-12 45.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.16 ESL06566.1 - 0.00021 20.7 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain PhoH PF02562.11 ESL06566.1 - 0.00039 19.7 0.0 0.00077 18.7 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.4 ESL06566.1 - 0.0024 16.9 0.1 0.009 15.0 0.0 2.1 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 ESL06566.1 - 0.0033 17.0 0.1 0.011 15.4 0.0 1.8 2 0 0 2 2 2 1 Helicase ResIII PF04851.10 ESL06566.1 - 0.0081 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESL06566.1 - 0.013 15.5 0.0 0.036 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 ESL06566.1 - 0.022 14.9 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL06566.1 - 0.025 14.6 0.1 1.1 9.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain Viral_helicase1 PF01443.13 ESL06566.1 - 0.026 14.0 0.0 1.2 8.6 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase TIP49 PF06068.8 ESL06566.1 - 0.038 12.7 0.0 0.058 12.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus DEAD PF00270.24 ESL06566.1 - 0.043 13.3 0.0 0.1 12.1 0.0 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase T2SE PF00437.15 ESL06566.1 - 0.11 11.3 0.0 0.21 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Peptidase_M29 PF02073.10 ESL06568.1 - 0.097 11.4 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) DUF4464 PF14713.1 ESL06569.1 - 1.5e-86 289.6 0.7 1.7e-86 289.4 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) Kelch_4 PF13418.1 ESL06571.1 - 4.2e-18 64.8 9.5 6.9e-06 25.7 0.0 7.5 7 2 0 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL06571.1 - 6.4e-16 58.0 8.1 1.5e-05 24.9 0.0 7.6 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL06571.1 - 5.8e-14 51.6 9.4 1.5e-05 24.8 0.1 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.1 ESL06571.1 - 9.5e-12 44.5 4.3 0.21 11.8 0.0 6.8 6 1 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESL06571.1 - 3.5e-10 39.2 2.5 0.16 11.5 0.1 6.0 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESL06571.1 - 4.2e-05 23.1 18.8 0.0041 16.8 0.0 7.2 7 1 0 7 7 7 1 Kelch motif TPT PF03151.11 ESL06572.1 - 1.7e-10 40.7 6.7 1.7e-10 40.7 4.6 2.3 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 ESL06572.1 - 2.5e-06 26.6 16.6 4.5e-06 25.7 11.5 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESL06572.1 - 0.00049 20.1 1.5 0.00049 20.1 1.1 2.5 2 1 0 2 2 2 1 EamA-like transporter family MORN PF02493.15 ESL06573.1 - 2.1e-25 86.8 36.3 4.2e-08 32.4 1.5 6.7 6 0 0 6 6 6 6 MORN repeat TFIIIC_sub6 PF10419.4 ESL06573.1 - 1.7 8.1 4.7 33 4.0 0.1 3.7 4 0 0 4 4 4 0 TFIIIC subunit Methyltransf_16 PF10294.4 ESL06575.1 - 7.5e-16 58.0 0.0 2.6e-15 56.2 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESL06575.1 - 0.0032 18.0 0.0 0.0052 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FAM86 PF14904.1 ESL06575.1 - 0.067 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function DUF1798 PF08807.5 ESL06575.1 - 0.14 11.9 0.1 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) zf-MYND PF01753.13 ESL06576.1 - 0.00024 20.9 2.9 0.00049 19.9 2.0 1.5 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.11 ESL06576.1 - 0.038 13.6 1.2 0.06 13.0 0.9 1.3 1 0 0 1 1 1 0 HIT zinc finger DUF2293 PF10056.4 ESL06576.1 - 0.11 12.4 1.7 3.1 7.8 0.2 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2293) P2 PF07194.6 ESL06576.1 - 0.19 11.6 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 P2 response regulator binding domain PIG-X PF08320.7 ESL06577.1 - 0.16 11.2 0.3 0.36 10.0 0.0 1.6 2 0 0 2 2 2 0 PIG-X / PBN1 IPK PF03770.11 ESL06578.1 - 3.6e-41 140.9 0.0 6.4e-41 140.1 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase TRAM_LAG1_CLN8 PF03798.11 ESL06579.1 - 3.7e-38 131.0 9.2 6.7e-38 130.2 6.4 1.4 1 1 0 1 1 1 1 TLC domain Nop PF01798.13 ESL06581.1 - 5.4e-13 48.4 0.4 8.7e-13 47.8 0.3 1.3 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 ESL06581.1 - 0.0011 19.3 1.9 0.0019 18.6 1.3 1.4 1 0 0 1 1 1 1 Prp31 C terminal domain CENP-U PF13097.1 ESL06581.1 - 0.13 12.2 1.2 0.2 11.5 0.8 1.2 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit Cofilin_ADF PF00241.15 ESL06582.1 - 1.3e-10 41.2 0.1 1.6e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Pkinase PF00069.20 ESL06584.1 - 3.4e-36 124.7 0.0 5.9e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06584.1 - 2.2e-17 62.9 0.0 8e-17 61.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESL06584.1 - 0.0079 15.0 0.1 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kinase-like PF14531.1 ESL06584.1 - 0.17 10.8 0.1 1.6 7.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like Fe-ADH PF00465.14 ESL06585.1 - 1.2e-117 392.6 4.2 1.4e-117 392.4 2.9 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 ESL06585.1 - 1.8e-18 66.7 1.5 5.5e-16 58.6 1.1 2.2 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Inositol_P PF00459.20 ESL06585.1 - 0.032 13.5 0.0 0.06 12.6 0.0 1.4 1 0 0 1 1 1 0 Inositol monophosphatase family PBP_GOBP PF01395.17 ESL06586.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 PBP/GOBP family Hexapep_2 PF14602.1 ESL06587.1 - 7.7e-06 25.3 0.1 0.00029 20.3 0.0 2.8 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.19 ESL06587.1 - 4.2e-05 22.8 0.3 0.0063 15.9 0.0 3.7 4 1 1 5 5 5 2 Bacterial transferase hexapeptide (six repeats) Y_phosphatase2 PF03162.8 ESL06588.1 - 1.2e-20 73.5 0.0 2.6e-20 72.4 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family Peptidase_M16 PF00675.15 ESL06591.1 - 3e-25 88.7 0.0 4.1e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESL06591.1 - 1.9e-11 44.0 0.0 4.4e-11 42.7 0.0 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain Spt5_N PF11942.3 ESL06592.1 - 0.054 14.1 7.3 0.51 10.9 0.9 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal GAGA PF09237.6 ESL06592.1 - 0.093 12.3 2.0 0.21 11.2 1.4 1.5 1 0 0 1 1 1 0 GAGA factor E1_dh PF00676.15 ESL06593.1 - 2.7e-78 262.7 0.0 3.9e-78 262.1 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DUF2802 PF10975.3 ESL06593.1 - 0.14 11.9 1.0 0.31 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) Pkinase PF00069.20 ESL06594.1 - 1.5e-66 224.2 0.0 2e-66 223.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06594.1 - 2.1e-36 125.3 0.0 2.9e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06594.1 - 2e-05 23.6 0.0 6.3e-05 22.0 0.0 1.8 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESL06594.1 - 0.021 14.5 0.1 1.4 8.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family MKT1_C PF12246.3 ESL06595.1 - 6.5e-51 172.6 0.0 9.8e-51 172.0 0.0 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 ESL06595.1 - 2.4e-21 75.8 0.0 7.1e-21 74.3 0.0 1.8 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 ESL06595.1 - 0.041 13.9 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 XPG I-region XPG_N PF00752.12 ESL06595.1 - 0.067 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 XPG N-terminal domain RuvB_N PF05496.7 ESL06596.1 - 0.016 14.2 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Sec20 PF03908.8 ESL06596.1 - 0.034 13.8 1.6 0.068 12.8 0.1 2.2 3 0 0 3 3 3 0 Sec20 Atg14 PF10186.4 ESL06596.1 - 0.53 9.1 7.5 0.66 8.8 3.5 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 ATP-synt_10 PF05176.9 ESL06598.1 - 2.8e-05 23.5 0.0 4.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 ATP10 protein AAA_19 PF13245.1 ESL06599.1 - 0.013 15.1 0.0 0.15 11.8 0.0 2.8 2 1 0 2 2 2 0 Part of AAA domain Ubiquitin_3 PF14836.1 ESL06600.1 - 0.13 11.9 0.2 0.32 10.7 0.0 1.6 2 0 0 2 2 2 0 Ubiquitin-like domain Rav1p_C PF12234.3 ESL06601.1 - 2.6e-40 138.2 0.0 5.3e-40 137.2 0.0 1.3 1 1 0 1 1 1 1 RAVE protein 1 C terminal Rhomboid PF01694.17 ESL06602.1 - 0.019 14.9 6.7 0.089 12.8 4.6 1.9 1 1 0 1 1 1 0 Rhomboid family COX6C PF02937.10 ESL06606.1 - 0.011 15.6 0.1 0.17 11.7 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc SHQ1 PF04925.10 ESL06607.1 - 2.7e-54 183.5 0.0 6.1e-54 182.3 0.0 1.5 2 0 0 2 2 2 1 SHQ1 protein KfrA_N PF11740.3 ESL06608.1 - 0.026 14.9 4.8 0.055 13.9 3.3 1.5 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term AKAP95 PF04988.7 ESL06608.1 - 0.11 12.2 0.2 0.11 12.2 0.2 2.3 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) DUF2312 PF10073.4 ESL06608.1 - 0.12 11.7 0.8 0.22 10.8 0.6 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) OmpH PF03938.9 ESL06608.1 - 4.2 7.2 8.1 8.8 6.2 5.6 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2453 PF10507.4 ESL06609.1 - 4.7e-41 139.0 3.2 4.7e-41 139.0 2.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2453) DUF883 PF05957.8 ESL06609.1 - 0.075 13.4 1.6 12 6.4 0.0 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DPBB_1 PF03330.13 ESL06609.1 - 0.65 10.0 3.0 16 5.5 2.1 2.3 1 1 0 1 1 1 0 Rare lipoprotein A (RlpA)-like double-psi beta-barrel EAP30 PF04157.11 ESL06611.1 - 2.9e-37 127.9 0.0 3.8e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 ESL06611.1 - 7.9e-16 57.6 0.0 1.6e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.15 ESL06611.1 - 0.058 12.9 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 GRAM domain WWbp PF10349.4 ESL06611.1 - 0.1 13.4 0.0 0.22 12.3 0.0 1.5 1 0 0 1 1 1 0 WW-domain ligand protein DUF2630 PF10944.3 ESL06611.1 - 0.11 12.6 0.2 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) Vps39_2 PF10367.4 ESL06612.1 - 4.2e-05 23.6 3.5 0.019 15.1 0.2 2.2 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 2 RecR PF02132.10 ESL06612.1 - 0.24 10.8 1.5 0.38 10.2 0.0 1.9 2 0 0 2 2 2 0 RecR protein Cupin_5 PF06172.6 ESL06613.1 - 6.3e-52 175.1 0.0 7.4e-52 174.9 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) zf-C3HC4_3 PF13920.1 ESL06614.1 - 7.6e-07 28.7 9.2 7.6e-07 28.7 6.4 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL06614.1 - 0.0096 15.7 12.2 0.0096 15.7 8.5 3.6 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL06614.1 - 0.014 15.3 12.5 0.014 15.3 8.6 3.8 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 ESL06615.1 - 2.2e-35 121.6 0.2 1.8e-34 118.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06615.1 - 5.5e-21 74.2 0.3 2.1e-20 72.3 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06615.1 - 1.3e-06 28.3 0.0 2.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 ESL06615.1 - 7.7e-05 21.8 0.0 0.00031 19.8 0.0 2.0 3 0 0 3 3 3 1 U3-containing 90S pre-ribosomal complex subunit Frataxin_Cyay PF01491.11 ESL06616.1 - 1.4e-25 89.2 0.0 1.7e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain FIST PF08495.5 ESL06616.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 FIST N domain Methyltransf_28 PF02636.12 ESL06617.1 - 8.6e-59 198.9 0.0 1.2e-58 198.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase tRNA-synt_1b PF00579.20 ESL06618.1 - 3.1e-19 69.1 0.0 6.5e-19 68.1 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) HATPase_c PF02518.21 ESL06619.1 - 3.9e-15 55.5 0.0 1.2e-14 53.9 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 ESL06619.1 - 0.046 13.5 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain zf-Dof PF02701.10 ESL06619.1 - 0.066 13.1 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Dof domain, zinc finger FOP_dimer PF09398.5 ESL06620.1 - 0.0055 16.6 0.0 0.0094 15.9 0.0 1.3 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LRR_6 PF13516.1 ESL06621.1 - 5.4e-28 93.8 15.0 8.5e-05 22.2 0.0 8.9 8 1 1 9 9 9 7 Leucine Rich repeat LRR_4 PF12799.2 ESL06621.1 - 8.7e-13 47.5 13.3 0.0012 18.3 0.1 5.8 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL06621.1 - 1.3e-09 36.7 14.9 1.6 9.0 0.0 8.2 7 2 0 7 7 7 3 Leucine Rich Repeat LRR_8 PF13855.1 ESL06621.1 - 1.9e-09 37.1 15.8 0.032 13.9 0.1 6.1 4 2 0 5 5 5 4 Leucine rich repeat LRR_7 PF13504.1 ESL06621.1 - 2.3e-07 29.9 15.3 3.9 8.1 0.0 8.8 8 1 0 8 8 8 1 Leucine rich repeat LRR_4 PF12799.2 ESL06625.1 - 8.2e-07 28.5 0.2 0.0019 17.7 0.0 3.2 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL06625.1 - 0.00016 21.4 5.0 7 7.0 0.0 5.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.1 ESL06625.1 - 0.00026 20.6 5.8 0.048 13.4 0.4 3.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 ESL06625.1 - 0.016 15.1 9.1 0.57 10.4 0.3 4.5 4 1 1 5 5 5 0 Leucine Rich Repeat Lectin_leg-like PF03388.8 ESL06626.1 - 7.3e-11 41.6 0.0 0.0001 21.5 0.0 4.4 5 0 0 5 5 5 2 Legume-like lectin family PBP1_TM PF14812.1 ESL06626.1 - 0.6 10.4 5.1 1.6 9.0 3.5 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mito_carr PF00153.22 ESL06627.1 - 1.1e-33 114.8 9.7 4.7e-20 71.0 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Pep_deformylase PF01327.16 ESL06629.1 - 2.1e-30 105.1 0.0 3.4e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Polypeptide deformylase Ras PF00071.17 ESL06631.1 - 1.9e-49 167.1 0.1 2.3e-49 166.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL06631.1 - 2.7e-21 76.2 0.1 3.8e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL06631.1 - 5.6e-15 55.0 0.1 7e-15 54.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL06631.1 - 1.5e-05 24.5 0.2 0.00031 20.2 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL06631.1 - 5.4e-05 22.4 0.0 6.7e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL06631.1 - 0.00022 21.1 0.0 0.00034 20.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESL06631.1 - 0.0016 17.6 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 ESL06631.1 - 0.036 13.6 0.1 0.084 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESL06631.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain Ribosomal_L18ae PF01775.12 ESL06632.1 - 1.8e-08 34.3 0.0 2.9e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain IncA PF04156.9 ESL06633.1 - 0.3 10.6 7.8 0.13 11.8 2.9 2.1 2 0 0 2 2 2 0 IncA protein Fib_alpha PF08702.5 ESL06633.1 - 5 7.2 7.3 17 5.5 2.4 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF904 PF06005.7 ESL06634.1 - 0.0012 19.1 11.6 0.013 15.8 4.6 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF904) HALZ PF02183.13 ESL06634.1 - 0.012 15.3 2.6 0.014 15.0 0.6 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper TMF_DNA_bd PF12329.3 ESL06634.1 - 0.018 14.8 7.9 0.084 12.6 0.7 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Transcrip_act PF04949.8 ESL06634.1 - 0.12 11.9 5.0 0.16 11.5 3.5 1.2 1 1 0 1 1 1 0 Transcriptional activator SlyX PF04102.7 ESL06634.1 - 0.48 10.8 5.4 5.7 7.3 3.7 2.5 1 1 0 1 1 1 0 SlyX DUF972 PF06156.8 ESL06634.1 - 5.4 7.4 7.6 3.7 7.9 2.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ATP-synt PF00231.14 ESL06635.1 - 4.9e-34 118.0 1.7 5.6e-34 117.8 1.2 1.0 1 0 0 1 1 1 1 ATP synthase Adaptin_binding PF10199.4 ESL06635.1 - 0.086 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Kinesin PF00225.18 ESL06636.1 - 2.6e-62 210.5 0.0 4.3e-62 209.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain AAA_16 PF13191.1 ESL06636.1 - 0.0002 21.4 0.0 0.00067 19.6 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESL06636.1 - 0.0098 16.0 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain RIIa PF02197.12 ESL06637.1 - 0.00043 19.6 0.0 0.0008 18.7 0.0 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit IQ PF00612.22 ESL06637.1 - 0.044 13.4 1.9 0.13 12.0 1.3 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif ARD PF03079.9 ESL06638.1 - 1.7e-26 93.0 0.2 1.7e-26 93.0 0.1 2.1 2 0 0 2 2 2 1 ARD/ARD' family AraC_binding PF02311.14 ESL06638.1 - 4.8e-05 23.0 0.0 9.6e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.6 ESL06638.1 - 0.0046 16.4 0.0 0.0075 15.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AAA_17 PF13207.1 ESL06638.1 - 0.037 14.8 3.5 0.078 13.8 0.2 2.3 2 0 0 2 2 2 0 AAA domain ARGLU PF15346.1 ESL06638.1 - 0.31 10.8 26.0 0.65 9.7 18.0 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 PV-1 PF06637.6 ESL06638.1 - 0.56 8.7 6.8 0.82 8.1 4.7 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) AAA_18 PF13238.1 ESL06638.1 - 0.64 10.3 7.5 0.37 11.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF2773 PF10971.3 ESL06638.1 - 1.3 9.0 4.3 14 5.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) DDRGK PF09756.4 ESL06638.1 - 3.5 6.9 22.2 5.9 6.2 15.4 1.3 1 0 0 1 1 1 0 DDRGK domain zf-Tim10_DDP PF02953.10 ESL06639.1 - 0.16 11.2 1.8 0.16 11.2 0.1 1.8 2 0 0 2 2 2 0 Tim10/DDP family zinc finger UQ_con PF00179.21 ESL06640.1 - 6.7e-45 151.9 0.0 7.6e-45 151.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESL06640.1 - 1.6e-05 24.6 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 ESL06640.1 - 0.0089 15.7 0.2 0.019 14.6 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 ESL06640.1 - 0.014 15.3 0.1 0.018 14.9 0.1 1.3 1 0 0 1 1 1 0 RWD domain Helicase_C_2 PF13307.1 ESL06643.1 - 8.5e-44 149.4 0.0 2.8e-43 147.7 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESL06643.1 - 2.2e-35 121.6 0.1 3.2e-35 121.0 0.1 1.3 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 ESL06643.1 - 0.00048 19.6 0.0 0.34 10.3 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESL06643.1 - 0.0011 18.8 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Prenyltrans PF00432.16 ESL06644.1 - 3.1e-16 58.6 8.6 1.2e-09 37.5 0.2 5.3 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESL06644.1 - 1.2e-06 28.8 0.0 0.00051 20.4 0.0 3.0 1 1 1 2 2 2 2 Prenyltransferase-like Ribosomal_60s PF00428.14 ESL06646.1 - 1 9.8 4.0 3.4 8.1 2.8 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pkinase PF00069.20 ESL06647.1 - 6.6e-64 215.5 0.0 7.9e-64 215.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06647.1 - 2e-28 99.2 0.0 1.3e-27 96.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06647.1 - 0.00047 19.2 0.0 0.00075 18.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESL06647.1 - 0.0011 18.1 0.1 0.0021 17.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL06647.1 - 0.0062 16.2 0.6 0.0094 15.7 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESL06647.1 - 0.077 11.8 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 CysG_dimeriser PF10414.4 ESL06647.1 - 0.15 11.5 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region TPR_11 PF13414.1 ESL06648.1 - 3.5e-32 109.8 12.4 4.5e-18 64.6 0.2 5.1 5 0 0 5 5 5 4 TPR repeat TPR_16 PF13432.1 ESL06648.1 - 8.6e-20 70.8 16.5 4.9e-08 33.4 0.1 5.2 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06648.1 - 8.9e-19 65.8 17.6 1.5e-06 27.6 0.0 6.0 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06648.1 - 1.8e-17 62.1 13.1 3e-06 26.5 0.0 5.7 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06648.1 - 5.3e-16 58.7 9.4 8.5e-06 26.0 0.4 5.1 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06648.1 - 2.1e-13 49.6 6.8 0.011 16.2 0.0 6.2 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06648.1 - 1.7e-10 39.8 8.9 0.034 13.9 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06648.1 - 2.9e-09 36.7 14.0 0.023 14.6 0.0 4.6 3 2 1 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06648.1 - 1.9e-08 33.4 6.6 0.034 13.9 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESL06648.1 - 1.1e-05 25.2 13.2 0.037 14.2 0.1 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESL06648.1 - 6.4e-05 22.7 2.3 0.1 12.4 0.0 4.6 5 1 1 6 6 6 1 Tetratricopeptide repeat MIT PF04212.13 ESL06648.1 - 0.00056 19.7 4.2 3.4 7.6 0.1 4.2 4 1 0 4 4 4 1 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.1 ESL06648.1 - 0.00082 19.2 3.5 0.013 15.3 0.2 3.6 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.1 ESL06648.1 - 0.0013 17.8 6.1 0.0071 15.4 0.1 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL06648.1 - 0.0014 18.4 5.3 3.4 7.7 0.3 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL06648.1 - 0.013 15.8 13.6 0.6 10.6 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat ChAPs PF09295.5 ESL06648.1 - 0.024 13.4 0.1 0.93 8.1 0.1 2.2 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) PPR PF01535.15 ESL06648.1 - 0.062 13.2 0.3 0.54 10.3 0.0 2.8 3 0 0 3 3 2 0 PPR repeat TPM PF04536.9 ESL06648.1 - 0.23 11.3 1.6 38 4.1 0.2 3.3 2 1 1 3 3 3 0 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase EF-hand_7 PF13499.1 ESL06649.1 - 8.6e-18 64.2 0.2 1.6e-07 31.3 0.2 4.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 ESL06649.1 - 2.1e-16 59.2 5.9 5.7e-07 29.0 0.2 4.9 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 ESL06649.1 - 4.8e-15 53.6 9.2 3.4e-05 22.8 0.8 5.0 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 ESL06649.1 - 1.1e-14 52.9 7.2 0.002 17.8 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 ESL06649.1 - 0.0076 15.5 9.6 0.028 13.7 0.3 4.0 4 0 0 4 4 4 1 EF hand EF-hand_4 PF12763.2 ESL06649.1 - 0.14 11.9 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand BCS1_N PF08740.6 ESL06650.1 - 1e-41 142.5 5.5 1.5e-41 142.0 3.8 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 ESL06650.1 - 2.5e-18 66.5 0.0 5.9e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL06650.1 - 0.0028 17.6 1.2 0.019 14.9 0.7 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESL06650.1 - 0.0028 18.4 0.0 0.006 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 ESL06650.1 - 0.0041 16.0 0.0 0.017 14.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 ESL06650.1 - 0.0061 16.2 0.0 0.021 14.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 ESL06650.1 - 0.0064 16.6 0.0 0.048 13.8 0.0 2.3 2 0 0 2 2 2 1 RNA helicase ABC_tran PF00005.22 ESL06650.1 - 0.012 15.8 0.0 0.091 13.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.1 ESL06650.1 - 0.012 15.4 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL06650.1 - 0.042 13.2 0.0 0.15 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESL06650.1 - 0.044 13.5 0.1 0.47 10.2 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain RuvB_N PF05496.7 ESL06650.1 - 0.056 12.4 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Rad17 PF03215.10 ESL06650.1 - 0.056 12.1 0.0 0.2 10.3 0.0 1.7 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESL06650.1 - 0.089 12.9 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESL06650.1 - 0.14 11.6 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF1857 PF08982.6 ESL06651.1 - 0.023 14.3 2.4 0.038 13.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1857) adh_short PF00106.20 ESL06652.1 - 5.4e-18 65.4 0.0 1.1e-17 64.5 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL06652.1 - 3.3e-08 33.4 0.0 6.8e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESL06652.1 - 9.2e-07 28.5 0.0 1.7e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESL06652.1 - 8.4e-06 25.7 0.0 1.6e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESL06652.1 - 0.0051 16.8 0.0 0.11 12.4 0.0 2.3 1 1 0 1 1 1 1 NADH(P)-binding GTP_EFTU PF00009.22 ESL06653.1 - 1.5e-24 86.4 0.0 2.5e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL06653.1 - 2.6e-14 53.1 0.4 1.1e-13 51.1 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL06653.1 - 1.2e-05 25.2 3.2 1.4e-05 25.0 0.2 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESL06653.1 - 0.0036 17.2 0.1 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase MobB PF03205.9 ESL06653.1 - 0.048 13.3 0.3 0.33 10.6 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 ESL06653.1 - 0.061 12.8 0.2 4.6 6.7 0.0 2.9 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DnaJ PF00226.26 ESL06654.1 - 1.3e-21 76.1 0.0 2.7e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESL06654.1 - 1.2e-10 41.0 0.2 2.1e-09 36.9 0.0 2.2 1 1 1 2 2 2 1 X-domain of DnaJ-containing DUF3487 PF11990.3 ESL06654.1 - 0.93 8.9 3.4 1.5 8.2 1.1 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3487) zf-C2H2_2 PF12756.2 ESL06655.1 - 5.8e-07 29.5 5.0 0.0025 17.9 0.1 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) CENP-B_dimeris PF09026.5 ESL06655.1 - 0.0094 16.1 0.2 0.02 15.1 0.1 1.6 1 0 0 1 1 1 1 Centromere protein B dimerisation domain zf-C2H2 PF00096.21 ESL06655.1 - 0.14 12.5 3.7 1.6 9.1 0.2 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Acyl_transf_1 PF00698.16 ESL06657.1 - 5.2e-23 81.8 0.4 6.9e-23 81.4 0.2 1.1 1 0 0 1 1 1 1 Acyl transferase domain Thymidylate_kin PF02223.12 ESL06658.1 - 2.3e-16 59.6 0.0 3.9e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Thymidylate kinase PPK2 PF03976.9 ESL06658.1 - 0.017 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) AAA_16 PF13191.1 ESL06658.1 - 0.023 14.7 0.2 0.046 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 ESL06658.1 - 0.028 14.1 0.1 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain Torsin PF06309.6 ESL06658.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Torsin AAA_22 PF13401.1 ESL06658.1 - 0.08 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-DHHC PF01529.15 ESL06659.1 - 2.1e-31 108.6 7.3 2.1e-31 108.6 5.0 1.6 1 1 0 1 1 1 1 DHHC palmitoyltransferase WW PF00397.21 ESL06660.1 - 4.7e-08 32.7 0.8 4.7e-08 32.7 0.6 2.0 2 0 0 2 2 2 1 WW domain HDAC4_Gln PF12203.3 ESL06660.1 - 0.062 13.2 2.4 0.27 11.2 1.7 2.1 1 1 0 1 1 1 0 Glutamine rich N terminal domain of histone deacetylase 4 Orbi_VP1 PF05788.7 ESL06660.1 - 0.079 10.1 0.0 0.1 9.7 0.0 1.1 1 0 0 1 1 1 0 Orbivirus RNA-dependent RNA polymerase (VP1) ATP-synt_D PF01813.12 ESL06663.1 - 0.14 11.6 0.6 0.74 9.3 0.4 2.1 1 1 0 1 1 1 0 ATP synthase subunit D ECH PF00378.15 ESL06665.1 - 3.9e-74 248.8 3.7 4.4e-74 248.6 2.6 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 ESL06665.1 - 0.00023 20.9 0.3 0.018 14.8 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 ECH_C PF13766.1 ESL06665.1 - 0.069 13.2 0.1 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 2-enoyl-CoA Hydratase C-terminal region Nitroreductase PF00881.19 ESL06666.1 - 4.1e-27 95.0 0.1 1.3e-26 93.4 0.1 1.7 1 1 0 1 1 1 1 Nitroreductase family NAPRTase PF04095.11 ESL06667.1 - 1.5e-65 220.8 0.0 2e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family CENP-F_leu_zip PF10473.4 ESL06669.1 - 0.014 15.2 1.0 0.028 14.2 0.7 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4472 PF14739.1 ESL06669.1 - 0.053 13.9 0.3 0.11 12.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) TruD PF01142.13 ESL06670.1 - 9.6e-05 21.2 0.0 0.00014 20.6 0.0 1.3 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) Pro_dh PF01619.13 ESL06671.1 - 2e-55 187.9 0.2 3.8e-55 187.0 0.2 1.4 1 0 0 1 1 1 1 Proline dehydrogenase EF-hand_8 PF13833.1 ESL06671.1 - 0.015 14.8 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair FAD_binding_5 PF00941.16 ESL06673.1 - 0.0041 16.5 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Peptidase_C2 PF00648.16 ESL06674.1 - 2.4e-47 161.3 0.0 3.1e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESL06674.1 - 2.8e-30 104.3 0.0 5.4e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) SLX9 PF15341.1 ESL06675.1 - 0.83 10.0 8.0 0.33 11.3 3.2 2.1 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 DNA_pol3_delta2 PF13177.1 ESL06676.1 - 6e-14 52.0 0.0 9e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 ESL06676.1 - 5.3e-13 49.3 0.1 8.3e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESL06676.1 - 4.8e-09 35.4 0.0 4e-05 22.5 0.0 2.1 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESL06676.1 - 5.2e-08 33.1 0.1 1.3e-07 31.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 ESL06676.1 - 1.2e-06 28.2 0.2 2.9e-06 27.0 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL06676.1 - 1.3e-05 25.2 0.5 0.0014 18.6 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 ESL06676.1 - 1.7e-05 24.4 0.1 4.6e-05 23.0 0.1 1.9 1 1 0 1 1 1 1 Part of AAA domain Mg_chelatase PF01078.16 ESL06676.1 - 2.4e-05 23.5 0.1 0.00059 19.0 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 ESL06676.1 - 2.6e-05 24.1 0.0 3.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.8 ESL06676.1 - 8.4e-05 22.1 0.7 0.00015 21.3 0.5 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.7 ESL06676.1 - 0.00018 20.6 0.0 0.00058 18.9 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_24 PF13479.1 ESL06676.1 - 0.00019 21.1 0.2 0.0032 17.0 0.1 2.2 1 1 1 2 2 2 1 AAA domain KTI12 PF08433.5 ESL06676.1 - 0.00026 20.2 0.0 0.00056 19.2 0.0 1.5 2 0 0 2 2 1 1 Chromatin associated protein KTI12 AAA_25 PF13481.1 ESL06676.1 - 0.00043 19.7 0.3 0.0014 18.0 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL06676.1 - 0.00048 19.8 0.4 0.0026 17.4 0.3 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DEAD PF00270.24 ESL06676.1 - 0.0007 19.1 0.6 0.063 12.7 0.1 2.3 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_11 PF13086.1 ESL06676.1 - 0.0011 18.5 0.3 0.0016 18.0 0.2 1.5 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 ESL06676.1 - 0.0023 17.4 0.0 0.0073 15.7 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 ESL06676.1 - 0.0032 16.9 0.0 0.0056 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA-like domain DUF2075 PF09848.4 ESL06676.1 - 0.0037 16.3 0.0 0.0054 15.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.8 ESL06676.1 - 0.005 15.5 0.4 1.7 7.2 0.0 2.6 3 0 0 3 3 3 2 TIP49 C-terminus IstB_IS21 PF01695.12 ESL06676.1 - 0.0079 15.6 0.5 0.047 13.1 0.4 2.1 1 1 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL06676.1 - 0.012 15.7 0.0 0.037 14.2 0.0 1.9 1 1 0 1 1 1 0 RNA helicase DUF3834 PF12916.2 ESL06676.1 - 0.013 14.4 0.0 0.033 13.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) ABC_tran PF00005.22 ESL06676.1 - 0.018 15.3 0.0 0.041 14.1 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.1 ESL06676.1 - 0.021 14.7 0.6 0.044 13.6 0.4 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 ESL06676.1 - 0.03 13.5 0.1 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein SRP54 PF00448.17 ESL06676.1 - 0.033 13.6 0.3 0.072 12.5 0.2 1.5 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.10 ESL06676.1 - 0.037 13.7 0.5 1.1 8.8 0.0 2.3 1 1 0 2 2 2 0 NTPase NACHT PF05729.7 ESL06676.1 - 0.045 13.4 0.1 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.1 ESL06676.1 - 0.061 13.2 0.7 0.2 11.6 0.4 1.9 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.6 ESL06676.1 - 0.094 12.3 0.3 2.8 7.5 0.2 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.18 ESL06676.1 - 0.1 11.3 0.5 2.6 6.7 0.0 2.2 1 1 0 2 2 2 0 SNF2 family N-terminal domain ArgK PF03308.11 ESL06676.1 - 0.12 11.1 0.4 9.6 4.8 0.0 2.3 1 1 1 2 2 2 0 ArgK protein AAA_18 PF13238.1 ESL06676.1 - 0.18 12.0 1.6 0.26 11.5 0.5 1.8 2 1 0 2 2 1 0 AAA domain DnaJ PF00226.26 ESL06678.1 - 6.2e-16 57.8 1.3 6.2e-16 57.8 0.9 2.4 3 0 0 3 3 3 1 DnaJ domain ADK PF00406.17 ESL06679.1 - 1.1 9.0 8.7 0.97 9.3 1.9 2.9 2 1 0 2 2 2 0 Adenylate kinase DnaJ PF00226.26 ESL06680.1 - 6.1e-21 73.9 1.2 6.1e-21 73.9 0.8 1.7 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.1 ESL06680.1 - 1e-05 25.0 3.9 3.8e-05 23.2 2.7 2.0 1 1 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 ESL06680.1 - 0.00027 20.3 7.1 0.00063 19.2 0.6 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06680.1 - 0.00059 19.5 1.3 0.00059 19.5 0.9 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06680.1 - 0.015 15.1 0.6 0.015 15.1 0.4 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL06680.1 - 0.06 13.1 0.4 0.06 13.1 0.3 3.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06680.1 - 0.11 13.1 1.5 0.49 11.1 0.8 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06680.1 - 0.21 11.4 2.0 0.32 10.8 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Lant_dehyd_N PF04737.8 ESL06681.1 - 0.021 14.8 0.2 0.053 13.5 0.1 1.7 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus UPF0506 PF11703.3 ESL06681.1 - 0.13 12.2 2.8 0.24 11.3 1.9 1.3 1 0 0 1 1 1 0 UPF0506 Vma12 PF11712.3 ESL06682.1 - 0.0013 18.4 1.3 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase TPR_12 PF13424.1 ESL06683.1 - 2.6e-10 40.0 1.2 8.7e-09 35.2 0.1 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06683.1 - 3.8e-05 23.2 0.1 3.8e-05 23.2 0.1 2.4 3 0 0 3 3 3 1 TPR repeat TPR_1 PF00515.23 ESL06683.1 - 0.00014 21.3 0.7 0.038 13.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL06683.1 - 0.00042 20.1 0.1 0.00042 20.1 0.1 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06683.1 - 0.0053 16.5 1.8 0.044 13.7 0.0 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06683.1 - 0.033 14.5 0.8 0.13 12.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL06683.1 - 0.045 13.5 2.0 0.24 11.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat THRAP3_BCLAF1 PF15440.1 ESL06683.1 - 0.72 8.4 14.2 1.2 7.7 9.8 1.2 1 0 0 1 1 1 0 THRAP3/BCLAF1 family zf-C3HC4_3 PF13920.1 ESL06685.1 - 3.3e-13 49.0 16.2 5.6e-13 48.3 11.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL06685.1 - 1.1e-05 25.3 18.4 2e-05 24.4 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL06685.1 - 0.00016 21.4 17.6 0.00031 20.5 12.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESL06685.1 - 0.015 14.9 18.7 0.027 14.1 12.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 ESL06685.1 - 0.032 13.7 8.2 0.063 12.8 5.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Vps52 PF04129.7 ESL06686.1 - 9.7e-09 34.2 3.9 0.0002 20.0 0.8 2.9 2 1 0 2 2 2 2 Vps52 / Sac2 family Imm35 PF15581.1 ESL06687.1 - 1.8 8.6 6.5 0.99 9.4 0.7 2.3 2 0 0 2 2 2 0 Immunity protein 35 Calici_MSP PF05752.6 ESL06687.1 - 1.8 8.1 7.2 1.3 8.5 0.5 2.3 2 0 0 2 2 2 0 Calicivirus minor structural protein IPK PF03770.11 ESL06689.1 - 9.3e-21 74.3 0.0 1.5e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase L27_1 PF09058.5 ESL06689.1 - 0.13 12.1 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 L27_1 DUF1126 PF06565.7 ESL06690.1 - 3.8e-31 106.2 0.1 6.5e-13 47.9 0.0 3.7 3 0 0 3 3 3 3 Repeat of unknown function (DUF1126) EF-hand_6 PF13405.1 ESL06690.1 - 7.6e-06 25.3 0.2 0.011 15.5 0.2 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 ESL06690.1 - 1.7e-05 23.8 0.9 0.00041 19.4 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 ESL06690.1 - 6.3e-05 23.0 0.0 0.31 11.2 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL06690.1 - 0.0002 20.8 0.6 0.01 15.4 0.2 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 ESL06690.1 - 0.035 13.4 0.3 0.096 12.0 0.2 1.8 1 0 0 1 1 1 0 EF hand ASF1_hist_chap PF04729.8 ESL06691.1 - 3.3e-49 166.4 0.0 3.9e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Tymo_coat PF00983.13 ESL06691.1 - 0.084 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Tymovirus coat protein ELFV_dehydrog PF00208.16 ESL06692.1 - 8.4e-46 156.5 0.0 1.5e-45 155.7 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 ESL06692.1 - 1e-15 56.3 0.1 1.8e-07 29.0 0.1 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 ESL06692.1 - 0.017 14.6 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain HlyIII PF03006.15 ESL06693.1 - 1.1e-21 77.2 18.1 1.5e-21 76.8 12.5 1.2 1 0 0 1 1 1 1 Haemolysin-III related Methyltransf_18 PF12847.2 ESL06694.1 - 1.8e-05 25.2 0.0 7.5e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESL06694.1 - 2e-05 23.8 0.4 3.1e-05 23.2 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 ESL06694.1 - 0.0007 19.0 0.1 0.0013 18.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ESL06694.1 - 0.0016 18.4 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 ESL06694.1 - 0.016 13.9 0.0 0.023 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.7 ESL06694.1 - 0.056 13.9 0.0 0.48 10.9 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.1 ESL06694.1 - 0.14 11.8 0.0 0.5 10.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain COQ9 PF08511.6 ESL06695.1 - 1.9e-05 24.0 0.0 0.0016 17.8 0.0 2.3 2 0 0 2 2 2 2 COQ9 AMP-binding PF00501.23 ESL06696.1 - 3.4e-82 276.0 0.1 4.7e-82 275.6 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Pkinase PF00069.20 ESL06699.1 - 2.2e-57 194.1 0.0 3.6e-57 193.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06699.1 - 3.9e-37 127.7 0.0 6.1e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.19 ESL06699.1 - 4.1e-05 23.3 0.0 0.00011 21.9 0.0 1.7 1 0 0 1 1 1 1 PAS fold Kinase-like PF14531.1 ESL06699.1 - 8.6e-05 21.6 0.0 0.22 10.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 ESL06699.1 - 0.0055 15.7 0.0 0.0096 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL06699.1 - 0.023 14.4 0.0 0.052 13.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SUR7 PF06687.7 ESL06699.1 - 1.8 8.0 10.0 0.53 9.8 3.9 2.2 2 0 0 2 2 2 0 SUR7/PalI family Prok-RING_1 PF14446.1 ESL06700.1 - 0.068 12.9 1.3 0.29 10.8 0.9 2.1 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Kinesin PF00225.18 ESL06702.1 - 1.6e-80 270.3 0.4 4.7e-80 268.7 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain ATP-synt_F6 PF05511.6 ESL06702.1 - 0.0049 16.7 0.9 0.31 10.9 0.2 2.7 2 0 0 2 2 2 1 Mitochondrial ATP synthase coupling factor 6 DUF1759 PF03564.10 ESL06702.1 - 0.17 11.7 11.5 0.054 13.3 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) TMF_DNA_bd PF12329.3 ESL06702.1 - 0.4 10.5 25.7 0.24 11.2 1.6 4.4 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding Gp58 PF07902.6 ESL06702.1 - 0.7 8.0 10.1 0.99 7.5 7.0 1.2 1 0 0 1 1 1 0 gp58-like protein CENP-F_leu_zip PF10473.4 ESL06702.1 - 0.75 9.6 23.2 0.2 11.5 3.0 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sulfatase_C PF14707.1 ESL06702.1 - 1.5 9.1 4.1 2.3 8.5 0.1 2.6 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase AAA_13 PF13166.1 ESL06702.1 - 1.7 6.9 15.6 2.8 6.2 10.8 1.3 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.7 ESL06702.1 - 2.7 7.7 24.0 9.9 5.9 6.2 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 ESL06702.1 - 4.7 6.7 24.2 5.7 6.4 3.0 2.5 1 1 1 2 2 2 0 IncA protein DUF3359 PF11839.3 ESL06702.1 - 5.1 7.4 9.5 0.33 11.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3359) Ded_cyto PF06920.8 ESL06703.1 - 0.034 13.4 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Dedicator of cytokinesis OB_NTP_bind PF07717.11 ESL06704.1 - 1e-24 86.5 0.0 2.3e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESL06704.1 - 3.5e-21 75.1 0.0 1.1e-20 73.5 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESL06704.1 - 4e-12 45.8 0.0 1.3e-11 44.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL06704.1 - 7.4e-09 35.3 0.7 1.8e-08 34.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESL06704.1 - 1.8e-06 28.0 0.5 7.7e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESL06704.1 - 0.0032 17.1 0.0 0.0097 15.6 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain SRP54 PF00448.17 ESL06704.1 - 0.016 14.6 0.1 0.058 12.8 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.1 ESL06704.1 - 0.021 14.3 0.1 0.089 12.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ResIII PF04851.10 ESL06704.1 - 0.056 13.2 0.9 9.7 5.9 0.0 2.6 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Arch_ATPase PF01637.13 ESL06704.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase cobW PF02492.14 ESL06704.1 - 0.091 12.1 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 ESL06704.1 - 0.091 12.6 0.1 1.2 9.0 0.1 2.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESL06704.1 - 0.11 12.7 0.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.1 ESL06704.1 - 0.2 11.9 0.0 0.2 11.9 0.0 2.1 2 1 0 2 2 1 0 AAA domain DnaJ PF00226.26 ESL06705.1 - 6.7e-10 38.5 0.0 1.7e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain SSXT PF05030.7 ESL06705.1 - 0.072 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 SSXT protein (N-terminal region) HEAT PF02985.17 ESL06706.1 - 1.8e-05 24.4 9.0 0.092 12.8 0.0 5.5 6 1 1 7 7 7 2 HEAT repeat Aldedh PF00171.17 ESL06707.1 - 2.6e-152 507.3 0.3 2.9e-152 507.2 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ESL06707.1 - 0.0034 16.6 0.1 0.0076 15.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) TruD PF01142.13 ESL06709.1 - 1.4e-05 24.0 0.0 0.0093 14.6 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) SPOUT_MTase_2 PF14419.1 ESL06709.1 - 0.14 11.3 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP E1-E2_ATPase PF00122.15 ESL06711.1 - 2.3e-19 69.3 0.0 6.5e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESL06711.1 - 2.9e-13 50.7 0.0 9.2e-12 45.8 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL06711.1 - 1.1e-12 48.4 0.1 2.7e-12 47.2 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL06711.1 - 2.5e-09 36.9 0.0 5.2e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESL06711.1 - 0.003 17.1 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S4_2 PF13275.1 ESL06711.1 - 0.016 14.8 0.2 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 S4 domain S4 PF01479.20 ESL06711.1 - 0.018 14.4 0.7 0.035 13.5 0.5 1.5 1 0 0 1 1 1 0 S4 domain API5 PF05918.6 ESL06712.1 - 0.0038 15.8 0.2 0.0038 15.8 0.1 2.5 2 1 1 3 3 3 1 Apoptosis inhibitory protein 5 (API5) HA2 PF04408.18 ESL06713.1 - 1.5e-15 57.0 0.0 3.9e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESL06713.1 - 1.7e-11 43.8 0.0 5.6e-11 42.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL06713.1 - 1e-08 34.8 0.0 4.2e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.11 ESL06713.1 - 0.0006 19.6 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.1 ESL06713.1 - 0.0026 17.9 0.1 0.011 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain dsrm PF00035.20 ESL06713.1 - 0.0061 17.1 4.5 0.021 15.3 0.0 3.7 4 0 0 4 4 4 1 Double-stranded RNA binding motif T2SE PF00437.15 ESL06713.1 - 0.0067 15.3 0.0 0.019 13.8 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein NB-ARC PF00931.17 ESL06713.1 - 0.023 13.5 0.0 0.043 12.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.11 ESL06713.1 - 0.027 13.7 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.1 ESL06713.1 - 0.082 12.6 5.0 0.39 10.5 0.0 4.0 4 0 0 4 4 4 0 Part of AAA domain KaiC PF06745.8 ESL06713.1 - 0.085 11.9 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 KaiC SCAN PF02023.12 ESL06713.1 - 0.13 11.7 1.0 0.28 10.6 0.1 2.0 2 0 0 2 2 2 0 SCAN domain Ribosomal_L12 PF00542.14 ESL06714.1 - 6.8e-17 61.2 0.9 6.8e-17 61.2 0.6 1.5 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.14 ESL06714.1 - 0.015 15.7 10.7 0.015 15.7 7.4 1.9 2 1 1 3 3 3 0 60s Acidic ribosomal protein DUF3824 PF12868.2 ESL06714.1 - 0.22 12.4 1.9 0.29 12.0 1.3 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF663 PF04950.7 ESL06715.1 - 4.8e-66 222.7 0.0 4.8e-66 222.7 0.0 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF663) DUF2992 PF11208.3 ESL06715.1 - 0.0058 16.5 5.0 0.0058 16.5 3.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2992) ABC2_membrane PF01061.19 ESL06716.1 - 1.4e-42 145.2 19.8 2.1e-42 144.7 13.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESL06716.1 - 2.7e-25 89.2 0.0 3.9e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESL06716.1 - 5.7e-08 33.0 0.2 6.6e-06 26.2 0.2 2.2 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESL06716.1 - 0.00015 21.0 0.0 0.00024 20.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESL06716.1 - 0.00038 19.9 0.1 0.0013 18.1 0.1 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 ESL06716.1 - 0.00051 20.0 0.4 0.0011 18.9 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESL06716.1 - 0.0025 17.9 0.0 0.0092 16.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 ESL06716.1 - 0.0041 16.3 0.7 7.5 5.7 0.0 3.1 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 ESL06716.1 - 0.0048 16.3 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL06716.1 - 0.013 16.2 0.0 0.03 15.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 ESL06716.1 - 0.017 13.9 0.1 0.027 13.2 0.1 1.4 1 0 0 1 1 1 0 ArgK protein Rad17 PF03215.10 ESL06716.1 - 0.031 12.9 0.0 0.044 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ABC2_membrane_3 PF12698.2 ESL06716.1 - 0.034 13.1 23.3 0.45 9.4 16.2 2.1 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA_28 PF13521.1 ESL06716.1 - 0.039 13.9 0.2 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL06716.1 - 0.04 14.2 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESL06716.1 - 0.045 14.0 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL06716.1 - 0.053 13.3 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 ESL06716.1 - 0.08 11.9 0.0 9.4 5.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.7 ESL06716.1 - 0.11 12.2 0.1 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_10 PF12846.2 ESL06716.1 - 0.15 11.4 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain TMEM95 PF15203.1 ESL06716.1 - 0.16 11.3 0.1 0.38 10.1 0.0 1.6 2 0 0 2 2 1 0 TMEM95 family DUF2254 PF10011.4 ESL06716.1 - 2.5 6.4 7.3 0.088 11.2 0.9 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) HEAT PF02985.17 ESL06718.1 - 9.3e-31 103.1 31.8 0.00041 20.1 0.1 12.3 12 0 0 12 12 12 9 HEAT repeat HEAT_2 PF13646.1 ESL06718.1 - 9.5e-28 96.3 16.1 5.4e-06 26.5 1.4 6.6 3 1 4 7 7 7 7 HEAT repeats HEAT_EZ PF13513.1 ESL06718.1 - 2.7e-12 46.7 26.0 0.0047 17.3 0.1 9.7 6 2 3 10 10 10 4 HEAT-like repeat Adaptin_N PF01602.15 ESL06718.1 - 5.9e-08 31.4 2.3 0.00024 19.5 1.8 4.6 2 1 1 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 ESL06718.1 - 4.6e-07 30.1 0.9 0.37 11.2 0.0 6.0 3 1 5 8 8 8 2 Vacuolar 14 Fab1-binding region Hypoth_Ymh PF09509.5 ESL06718.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (Hypoth_ymh) Arm PF00514.18 ESL06718.1 - 0.31 10.9 3.8 21 5.1 0.0 4.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Peptidase_M8 PF01457.11 ESL06720.1 - 1.6e-14 53.1 2.3 2e-14 52.8 1.6 1.1 1 0 0 1 1 1 1 Leishmanolysin RRM_6 PF14259.1 ESL06721.1 - 1.6e-13 50.3 0.0 2.9e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL06721.1 - 4.7e-11 42.1 0.0 7.2e-11 41.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06721.1 - 2.2e-05 24.2 0.0 3.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRM PF02005.11 ESL06722.1 - 1.2e-100 337.0 4.2 2.4e-71 240.6 1.6 3.0 2 1 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Brix PF04427.13 ESL06723.1 - 4.7e-41 140.5 0.0 6.7e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain DUF1682 PF07946.9 ESL06723.1 - 6.4 5.5 10.3 10 4.8 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) UCH PF00443.24 ESL06724.1 - 4.1e-27 94.9 0.0 1.7e-26 92.9 0.0 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL06724.1 - 0.00021 20.8 3.5 0.05 13.0 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Cas_CXXC_CXXC PF09706.5 ESL06724.1 - 0.024 14.8 0.2 0.41 10.8 0.0 2.8 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_CXXC_CXXC) HEAT_EZ PF13513.1 ESL06724.1 - 0.29 11.6 1.5 50 4.5 0.0 3.7 3 0 0 3 3 3 0 HEAT-like repeat Dicty_REP PF05086.7 ESL06724.1 - 1 7.0 0.3 1.6 6.3 0.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SpoIIE PF07228.7 ESL06726.1 - 3.1e-14 53.1 0.5 9.4e-13 48.3 0.4 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESL06726.1 - 4.1e-07 29.6 0.2 8.3e-07 28.6 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 ESL06726.1 - 3.6e-05 23.2 0.0 0.00013 21.4 0.0 1.8 2 0 0 2 2 2 1 Protein phosphatase 2C AIRS_C PF02769.17 ESL06727.1 - 3.9e-16 59.4 0.1 8e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 ESL06727.1 - 5.9e-07 29.6 0.0 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain Extensin-like_C PF06904.7 ESL06727.1 - 0.055 13.2 0.0 0.099 12.4 0.0 1.3 1 0 0 1 1 1 0 Extensin-like protein C-terminus PEPCK_ATP PF01293.15 ESL06728.1 - 0.15 10.5 0.0 0.21 10.0 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase F-box-like PF12937.2 ESL06729.1 - 0.013 15.2 2.7 0.14 11.8 0.2 2.5 2 0 0 2 2 2 0 F-box-like 7TM_GPCR_Sri PF10327.4 ESL06729.1 - 0.12 11.2 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri FG-GAP PF01839.18 ESL06731.1 - 0.0033 17.0 1.3 0.0065 16.1 0.4 2.0 2 0 0 2 2 2 1 FG-GAP repeat ABC_tran PF00005.22 ESL06732.1 - 2.1e-34 118.7 0.0 6.1e-34 117.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.18 ESL06732.1 - 5.8e-20 71.8 2.2 7.4e-20 71.5 1.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 ESL06732.1 - 7.4e-07 28.6 0.2 2.3e-05 23.7 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESL06732.1 - 3.4e-05 23.9 0.0 0.024 14.5 0.0 2.3 1 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESL06732.1 - 0.003 17.0 0.2 0.009 15.5 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 ESL06732.1 - 0.0033 17.4 0.0 0.0083 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 ESL06732.1 - 0.044 12.9 0.0 0.095 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 CbiA PF01656.18 ESL06732.1 - 0.055 12.8 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 ESL06732.1 - 0.071 13.9 0.0 0.21 12.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.1 ESL06732.1 - 0.079 12.8 0.1 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 ESL06732.1 - 0.13 12.0 1.1 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF87 G-alpha PF00503.15 ESL06732.1 - 0.22 10.1 0.0 0.45 9.1 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit AAA_23 PF13476.1 ESL06732.1 - 3.3 7.9 5.2 2 8.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain polyprenyl_synt PF00348.12 ESL06733.1 - 4.3e-23 81.4 0.1 5.3e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.14 ESL06733.1 - 4e-05 23.0 0.5 5.4e-05 22.6 0.4 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase MORN PF02493.15 ESL06734.1 - 7.6e-45 148.0 68.0 2.2e-08 33.3 0.2 10.4 10 0 0 10 10 10 10 MORN repeat Arm PF00514.18 ESL06736.1 - 1.1e-05 25.1 0.3 3.6 7.5 0.0 5.2 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat Kdo PF06293.9 ESL06738.1 - 1e-09 37.8 0.1 1.4e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESL06738.1 - 3.6e-08 32.8 0.0 4.4e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESL06738.1 - 6.8e-07 28.8 0.0 1.9e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.12 ESL06738.1 - 0.00029 19.9 0.0 0.00037 19.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL06738.1 - 0.0029 17.3 0.6 1 9.0 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.20 ESL06739.1 - 1e-64 218.1 0.0 3e-64 216.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06739.1 - 4.5e-44 150.4 0.0 6.4e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06739.1 - 0.012 14.6 0.0 0.032 13.1 0.0 1.6 1 1 0 1 1 1 0 Kinase-like APH PF01636.18 ESL06739.1 - 0.038 13.7 0.2 7.9 6.1 0.1 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family tRNA_anti-codon PF01336.20 ESL06740.1 - 4.2e-05 23.3 0.1 6.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain EspB PF05802.6 ESL06740.1 - 0.011 14.7 1.8 0.012 14.5 1.3 1.2 1 0 0 1 1 1 0 Enterobacterial EspB protein GET2 PF08690.5 ESL06742.1 - 0.21 10.7 2.7 0.24 10.6 1.8 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 HMG_box PF00505.14 ESL06742.1 - 1.2 9.3 9.3 12 6.3 0.1 2.6 2 1 0 2 2 2 0 HMG (high mobility group) box GTP_EFTU PF00009.22 ESL06743.1 - 9.1e-55 185.0 0.0 1.5e-54 184.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL06743.1 - 8.6e-36 122.0 0.1 4.1e-35 119.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL06743.1 - 3.2e-18 65.6 0.6 9.6e-18 64.0 0.4 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 ESL06743.1 - 1.6e-05 24.4 0.1 5.6e-05 22.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 ESL06743.1 - 3.5e-05 23.7 0.0 0.00072 19.5 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL06743.1 - 0.0037 17.7 0.2 0.087 13.3 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL06743.1 - 0.031 13.3 0.0 0.074 12.1 0.0 1.6 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Semialdhyde_dhC PF02774.13 ESL06743.1 - 0.04 13.7 0.1 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Pkinase PF00069.20 ESL06744.1 - 2e-46 158.2 0.0 7.3e-34 117.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06744.1 - 7.8e-26 90.6 0.0 4.6e-22 78.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DSPc PF00782.15 ESL06744.1 - 9.3e-24 83.5 0.0 2e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.2 ESL06744.1 - 2.6e-17 62.0 14.0 1.1e-08 34.4 1.3 4.2 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL06744.1 - 1e-11 44.3 9.0 1e-09 37.9 1.2 4.1 4 1 1 5 5 5 2 Leucine rich repeat LRR_1 PF00560.28 ESL06744.1 - 4.7e-11 41.1 5.2 0.046 13.7 0.0 5.4 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 ESL06744.1 - 1.8e-07 30.1 1.1 0.36 11.2 0.1 5.0 4 0 0 4 4 4 2 Leucine rich repeat Kinase-like PF14531.1 ESL06744.1 - 0.00052 19.0 0.0 0.0078 15.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Y_phosphatase PF00102.22 ESL06744.1 - 0.01 15.1 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase LRR_6 PF13516.1 ESL06744.1 - 0.038 14.0 2.1 44 4.5 0.0 4.3 3 1 0 3 3 3 0 Leucine Rich repeat WD40 PF00400.27 ESL06745.1 - 7.2e-19 66.8 6.5 0.0093 15.8 0.0 10.1 11 0 0 11 11 11 6 WD domain, G-beta repeat Sod_Fe_C PF02777.13 ESL06746.1 - 1.4e-44 150.2 2.0 8.1e-44 147.8 0.3 2.0 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 ESL06746.1 - 4e-21 75.0 1.5 4.5e-21 74.9 0.1 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Aldose_epim PF01263.15 ESL06747.1 - 6.4e-60 202.7 0.0 9.1e-60 202.2 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase Metallophos PF00149.23 ESL06748.1 - 1.9e-11 43.7 0.1 3.5e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL06748.1 - 4.4e-10 39.6 0.0 6.3e-10 39.1 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2891 PF11199.3 ESL06748.1 - 0.14 10.6 0.0 0.19 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) Nterm_IS4 PF13006.2 ESL06749.1 - 0.042 13.8 0.0 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal DUF1767 PF08585.7 ESL06751.1 - 5.4e-16 58.6 0.0 9e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1767) FoP_duplication PF13865.1 ESL06751.1 - 6.5 7.2 6.0 11 6.6 4.2 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 PIH1 PF08190.7 ESL06753.1 - 1e-107 360.4 0.0 1e-107 360.4 0.0 1.6 2 0 0 2 2 2 1 pre-RNA processing PIH1/Nop17 HALZ PF02183.13 ESL06754.1 - 0.014 15.0 2.0 0.014 15.0 1.4 3.8 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF4415 PF14384.1 ESL06754.1 - 0.1 12.7 0.1 0.37 10.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4415) LSM PF01423.17 ESL06755.1 - 2.1e-09 36.8 0.1 3.1e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESL06755.1 - 0.044 13.6 0.2 0.15 11.9 0.0 1.8 1 1 1 2 2 2 0 Ataxin 2 SM domain DUF1900 PF08954.6 ESL06756.1 - 1.6e-41 141.0 0.0 3.2e-41 140.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1900) WD40 PF00400.27 ESL06756.1 - 2.2e-19 68.5 0.3 1.1e-05 25.1 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat DUF1899 PF08953.6 ESL06756.1 - 7e-08 32.0 0.0 1.4e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) DUF2780 PF11075.3 ESL06757.1 - 0.017 15.1 0.6 2.5 8.1 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function VcgC/VcgE (DUF2780) DnaB_2 PF07261.6 ESL06757.1 - 0.082 12.5 0.0 4.7 6.8 0.0 2.9 2 0 0 2 2 2 0 Replication initiation and membrane attachment PhageMin_Tail PF10145.4 ESL06757.1 - 0.16 11.5 7.8 1.8 8.1 0.1 3.5 3 1 2 5 5 5 0 Phage-related minor tail protein plasmid_Toxin PF12703.2 ESL06757.1 - 0.64 9.8 5.9 2.4 8.0 0.1 3.8 4 0 0 4 4 4 0 Toxin of toxin-antitoxin type 1 system DUF4570 PF15134.1 ESL06758.1 - 0.16 11.8 2.4 0.32 10.8 1.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) WD40 PF00400.27 ESL06758.1 - 1.8 8.5 4.3 9.9 6.2 0.1 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat Ribosomal_60s PF00428.14 ESL06758.1 - 4.8 7.6 12.0 9.7 6.6 6.5 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DEAD PF00270.24 ESL06759.1 - 6.6e-16 58.2 0.0 2e-15 56.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06759.1 - 2.7e-14 52.7 0.7 1.4e-13 50.4 0.4 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pkinase PF00069.20 ESL06760.1 - 1.8e-08 33.8 0.2 0.0024 17.0 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain zf-CCCH PF00642.19 ESL06761.1 - 0.011 15.4 13.2 0.2 11.3 2.1 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DEAD PF00270.24 ESL06763.1 - 5e-19 68.4 0.0 1.6e-18 66.7 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06763.1 - 7.4e-07 28.9 0.2 3.4e-06 26.8 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06763.1 - 2.7e-06 27.3 0.4 6e-05 22.9 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2404 PF10296.4 ESL06764.1 - 0.0025 17.9 0.0 0.006 16.6 0.0 1.6 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Fes1 PF08609.5 ESL06765.1 - 0.0096 16.3 0.0 0.032 14.7 0.0 1.9 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 ESL06765.1 - 0.016 15.4 5.5 2.6 8.3 0.1 3.5 3 1 0 3 3 3 0 HEAT repeats FlaG PF03646.10 ESL06765.1 - 0.07 13.2 0.1 6.1 7.0 0.0 2.6 3 0 0 3 3 3 0 FlaG protein TarH PF02203.10 ESL06766.1 - 0.11 12.3 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue TRAM_LAG1_CLN8 PF03798.11 ESL06767.1 - 4.5e-11 42.6 16.2 4.5e-11 42.6 11.2 2.2 1 1 0 1 1 1 1 TLC domain CorA PF01544.13 ESL06769.1 - 5.5e-41 140.5 0.0 7.5e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1478 PF07349.6 ESL06769.1 - 0.061 12.7 0.0 0.17 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1478) DUF572 PF04502.8 ESL06770.1 - 0.15 11.2 4.6 0.18 10.9 3.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TPR_2 PF07719.12 ESL06771.1 - 8e-06 25.3 0.4 1.5 8.9 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06771.1 - 0.00025 21.3 2.6 0.087 13.5 0.2 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06771.1 - 0.00049 19.9 0.3 0.013 15.4 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL06771.1 - 0.0018 17.8 1.5 0.12 12.0 0.6 2.8 1 1 3 4 4 4 2 TPR repeat TPR_1 PF00515.23 ESL06771.1 - 0.007 15.9 0.3 3 7.6 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESL06771.1 - 0.036 13.1 0.2 0.17 10.9 0.2 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06771.1 - 0.038 14.3 1.5 0.49 10.7 0.2 2.8 1 1 1 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL06771.1 - 0.067 13.3 0.0 0.56 10.3 0.0 2.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.2 ESL06771.1 - 0.12 12.3 0.2 1.2 9.1 0.0 2.2 1 1 0 2 2 2 0 Tetratrico peptide repeat Pho88 PF10032.4 ESL06772.1 - 8.5e-30 103.4 0.0 9.8e-30 103.1 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Pex2_Pex12 PF04757.9 ESL06773.1 - 1.1e-28 100.1 8.6 1.5e-28 99.8 6.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.20 ESL06773.1 - 0.13 11.9 10.5 0.24 11.0 7.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL06773.1 - 1.3 8.8 9.4 3 7.6 6.5 1.6 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESL06773.1 - 1.7 8.3 9.2 3.2 7.5 6.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL06773.1 - 2.9 7.9 10.4 7.5 6.6 7.2 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IGR PF09597.5 ESL06774.1 - 0.0042 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 IGR protein motif FUSC PF04632.7 ESL06779.1 - 0.11 10.8 3.9 0.15 10.4 2.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family ABC1 PF03109.11 ESL06782.1 - 4.2e-22 78.3 0.0 1e-21 77.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family TrbI_Ftype PF09677.5 ESL06782.1 - 0.093 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) RRS1 PF04939.7 ESL06783.1 - 6.1e-47 159.1 7.6 8.6e-47 158.6 5.3 1.2 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) UPF0016 PF01169.14 ESL06784.1 - 2.5e-24 85.1 13.0 4.5e-23 81.1 4.9 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF1212 PF06738.7 ESL06784.1 - 0.46 9.9 5.2 0.72 9.2 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) RCC1 PF00415.13 ESL06785.1 - 1.4e-30 105.2 16.0 1.4e-14 54.0 0.1 7.4 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL06785.1 - 3.6e-14 51.9 7.4 0.00037 20.0 0.1 5.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat SAC3_GANP PF03399.11 ESL06786.1 - 0.04 13.4 0.1 0.93 9.0 0.1 2.4 2 0 0 2 2 2 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family NLE PF08154.7 ESL06786.1 - 0.059 13.4 0.1 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 NLE (NUC135) domain Prefoldin PF02996.12 ESL06787.1 - 3.9e-21 74.9 1.0 5e-21 74.5 0.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 ESL06787.1 - 0.014 15.1 1.5 0.16 11.7 0.1 2.2 2 0 0 2 2 2 0 Prefoldin subunit KxDL PF10241.4 ESL06787.1 - 0.016 15.0 0.4 0.09 12.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein End3 PF12761.2 ESL06787.1 - 0.1 12.2 2.2 0.29 10.7 1.4 2.0 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Sec2p PF06428.6 ESL06787.1 - 0.12 12.2 5.4 2.1 8.2 1.2 2.3 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF972 PF06156.8 ESL06787.1 - 0.22 11.8 3.3 2.1 8.7 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DASH_Dam1 PF08653.5 ESL06787.1 - 0.34 10.7 1.5 18 5.2 0.1 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF2962 PF11176.3 ESL06788.1 - 0.3 10.6 3.5 1.7 8.2 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2962) Herpes_UL6 PF01763.11 ESL06790.1 - 0.038 12.1 0.0 0.04 12.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like NAD_binding_1 PF00175.16 ESL06791.1 - 1e-26 93.6 0.0 3.4e-26 91.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL06791.1 - 1.3e-24 86.1 0.0 2.1e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESL06791.1 - 2.5e-06 27.5 0.0 0.0011 18.8 0.0 2.4 1 1 0 2 2 2 2 Ferric reductase NAD binding domain zf-RING_2 PF13639.1 ESL06792.1 - 3e-12 46.1 8.6 5.1e-12 45.4 6.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESL06792.1 - 4.8e-10 39.3 9.4 8e-10 38.6 6.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESL06792.1 - 1e-05 25.0 6.7 1.8e-05 24.2 4.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL06792.1 - 5.8e-05 23.0 8.4 0.00012 22.0 5.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL06792.1 - 0.00013 21.7 6.1 0.00023 20.9 4.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 ESL06792.1 - 0.00033 20.3 8.8 0.00062 19.4 6.0 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL06792.1 - 0.00036 20.1 8.0 0.00064 19.3 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 ESL06792.1 - 0.19 11.3 4.5 0.38 10.2 3.1 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESL06792.1 - 0.44 10.3 5.9 2.8 7.7 4.1 2.3 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.3 ESL06792.1 - 0.47 10.4 9.9 2.2 8.2 6.9 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 ESL06792.1 - 2.1 8.4 9.9 5.1 7.2 6.9 1.7 1 1 0 1 1 1 0 RING-variant domain MORN PF02493.15 ESL06793.1 - 1.1e-18 65.7 40.4 3.9e-06 26.2 0.3 9.9 10 1 1 11 11 11 5 MORN repeat WW PF00397.21 ESL06793.1 - 0.0077 16.0 0.3 0.0077 16.0 0.2 2.1 2 0 0 2 2 2 1 WW domain ERM PF00769.14 ESL06793.1 - 0.75 9.2 37.9 0.033 13.7 19.2 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family SUI1 PF01253.17 ESL06794.1 - 1.1e-19 70.0 0.1 1.9e-19 69.2 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 CENP-B_N PF04218.8 ESL06794.1 - 0.071 12.5 1.3 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain JAB PF01398.16 ESL06795.1 - 7.1e-31 106.3 0.0 1.1e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESL06795.1 - 1.6e-09 37.2 0.0 2.5e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.1 ESL06795.1 - 1.1e-08 35.1 0.0 2.3e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.8 ESL06795.1 - 0.0025 17.3 0.0 0.0061 16.0 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) DEAD PF00270.24 ESL06796.1 - 6.9e-39 133.0 0.0 4.7e-38 130.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase GUCT PF08152.7 ESL06796.1 - 1.8e-25 88.7 0.0 3.5e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 GUCT (NUC152) domain Helicase_C PF00271.26 ESL06796.1 - 1.4e-23 82.5 0.0 2.9e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06796.1 - 0.0069 16.2 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ANF_receptor PF01094.23 ESL06798.1 - 5.6e-05 22.0 0.1 6.1e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region MrpF_PhaF PF04066.8 ESL06798.1 - 0.49 10.7 4.9 0.68 10.2 1.2 2.2 2 0 0 2 2 2 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) Ribosomal_S4 PF00163.14 ESL06799.1 - 1.2e-27 96.1 0.5 1.2e-27 96.1 0.3 1.6 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 ESL06799.1 - 7.6e-13 47.6 0.4 1.7e-12 46.5 0.3 1.6 1 0 0 1 1 1 1 S4 domain SPO22 PF08631.5 ESL06800.1 - 0.027 13.5 0.1 0.031 13.3 0.1 1.1 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF1847 PF08901.6 ESL06800.1 - 0.1 12.1 0.2 1.5 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1847) TPR_20 PF14561.1 ESL06800.1 - 0.17 12.0 1.4 0.59 10.2 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat IFT57 PF10498.4 ESL06801.1 - 0.0037 16.0 0.0 0.0063 15.2 0.0 1.3 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Y_phosphatase2 PF03162.8 ESL06802.1 - 2.7e-53 179.7 0.0 3.6e-53 179.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESL06802.1 - 1.1e-08 35.5 0.0 3.4e-08 33.9 0.0 1.7 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESL06802.1 - 0.00024 20.5 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 ESL06802.1 - 0.0052 16.3 0.0 0.0078 15.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Myotub-related PF06602.9 ESL06802.1 - 0.033 12.9 0.0 0.046 12.4 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain PTPlike_phytase PF14566.1 ESL06802.1 - 0.06 13.3 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate ENT PF03735.9 ESL06803.1 - 0.00069 19.2 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 ENT domain RRM_1 PF00076.17 ESL06804.1 - 3.6e-29 100.2 0.0 8.2e-13 47.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06804.1 - 2.9e-24 84.8 0.0 7e-11 41.9 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06804.1 - 6e-12 45.2 0.1 0.00058 19.6 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESL06804.1 - 8.2e-06 25.4 0.0 0.0011 18.7 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.6 ESL06804.1 - 3.1e-05 23.8 0.1 0.0019 18.1 0.0 2.5 2 1 0 2 2 2 1 RNA binding domain Nup35_RRM PF05172.8 ESL06804.1 - 0.00035 20.2 0.1 0.62 9.8 0.0 2.8 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Kin17_mid PF10357.4 ESL06804.1 - 0.0067 16.0 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein RRM_3 PF08777.6 ESL06804.1 - 0.025 14.4 0.1 11 5.8 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif HECT PF00632.20 ESL06805.1 - 1.5e-47 162.3 0.0 3.5e-47 161.1 0.0 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Rad51 PF08423.6 ESL06806.1 - 1.5e-134 446.7 0.2 2.2e-134 446.2 0.1 1.2 1 0 0 1 1 1 1 Rad51 RecA PF00154.16 ESL06806.1 - 4.5e-13 48.9 0.2 5.9e-13 48.5 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.1 ESL06806.1 - 7.4e-10 38.5 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 ESL06806.1 - 5.4e-07 29.6 1.1 1.4e-06 28.3 0.7 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain KaiC PF06745.8 ESL06806.1 - 1.3e-06 27.7 0.0 2.3e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 KaiC DnaB_C PF03796.10 ESL06806.1 - 0.023 13.6 0.1 0.046 12.6 0.1 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Lysine_decarbox PF03641.9 ESL06807.1 - 6.9e-24 84.1 0.0 1.3e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase DUF778 PF05608.7 ESL06809.1 - 5.3e-44 149.4 0.0 6.3e-44 149.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF778) Peptidase_C97 PF05903.9 ESL06809.1 - 0.031 14.0 0.1 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain FhuF PF06276.7 ESL06809.1 - 0.039 13.9 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 Ferric iron reductase FhuF-like transporter DUF4105 PF13387.1 ESL06809.1 - 0.068 12.3 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) HSP70 PF00012.15 ESL06810.1 - 2e-72 244.0 0.1 3.1e-72 243.3 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL06810.1 - 2.3e-05 23.1 0.0 8.1e-05 21.3 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein DUF4582 PF15189.1 ESL06810.1 - 0.028 13.6 1.6 0.038 13.2 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4582) LSM PF01423.17 ESL06811.1 - 1.7e-13 49.8 1.0 2.3e-13 49.4 0.7 1.1 1 0 0 1 1 1 1 LSM domain HA2 PF04408.18 ESL06812.1 - 1e-17 63.9 0.0 3.1e-17 62.4 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESL06812.1 - 1.2e-15 57.2 0.0 1.5e-14 53.8 0.0 2.5 2 1 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESL06812.1 - 4e-14 52.2 0.0 1e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL06812.1 - 6.5e-10 38.7 0.0 1.9e-09 37.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESL06812.1 - 0.0006 19.9 0.7 0.0052 16.9 0.5 2.5 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 ESL06812.1 - 0.0052 17.2 0.0 0.052 14.0 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein T2SE PF00437.15 ESL06812.1 - 0.018 13.9 0.9 0.038 12.8 0.6 1.6 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.1 ESL06812.1 - 0.028 14.1 0.0 0.091 12.5 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain KaiC PF06745.8 ESL06812.1 - 0.036 13.1 0.0 0.1 11.6 0.0 1.7 1 0 0 1 1 1 0 KaiC cobW PF02492.14 ESL06812.1 - 0.043 13.2 0.1 1.5 8.2 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 ESL06812.1 - 0.048 13.0 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESL06812.1 - 0.084 13.1 0.1 0.26 11.5 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.1 ESL06812.1 - 0.12 12.2 1.2 3.2 7.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 ESL06812.1 - 0.16 12.3 0.1 0.16 12.3 0.1 2.5 1 1 1 2 2 1 0 AAA domain Rep_1 PF01446.12 ESL06813.1 - 0.081 12.2 0.1 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Replication protein Baculo_PEP_C PF04513.7 ESL06813.1 - 0.18 11.6 5.4 0.34 10.7 0.6 2.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Gsf2 PF11055.3 ESL06814.1 - 0.2 10.1 0.1 0.35 9.3 0.0 1.3 1 0 0 1 1 1 0 Glucose signalling factor 2 TFIIS_M PF07500.9 ESL06815.1 - 0.007 16.4 0.2 0.029 14.4 0.2 1.9 1 1 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain EF-hand_1 PF00036.27 ESL06816.1 - 1.9e-10 39.2 0.3 2.3e-06 26.5 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 ESL06816.1 - 1.3e-09 38.0 1.3 8.8e-06 25.7 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL06816.1 - 1.3e-08 33.9 0.3 9e-05 22.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 ESL06816.1 - 1.4e-05 24.1 0.1 4.3e-05 22.6 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 ESL06816.1 - 0.00011 21.7 2.3 0.0024 17.4 0.1 3.3 3 0 0 3 3 3 1 EF-hand domain pair Peptidase_M1 PF01433.15 ESL06817.1 - 4.9e-48 164.1 0.0 6e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M1 zf-CCCH PF00642.19 ESL06818.1 - 2.3e-07 30.3 4.1 4.6e-07 29.3 2.8 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Serglycin PF04360.7 ESL06818.1 - 0.0098 15.6 1.1 0.017 14.8 0.0 1.9 2 0 0 2 2 2 1 Serglycin zf-CCCH_2 PF14608.1 ESL06818.1 - 0.033 14.1 7.2 0.061 13.3 5.0 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type UvdE PF03851.9 ESL06819.1 - 0.004 16.2 0.1 0.0069 15.4 0.0 1.3 1 0 0 1 1 1 1 UV-endonuclease UvdE Histone PF00125.19 ESL06820.1 - 6.1e-24 83.9 0.2 1.2e-23 82.9 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL06820.1 - 1.1e-06 28.6 0.0 2.2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESL06820.1 - 0.0056 16.3 0.1 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated CENP-S PF15630.1 ESL06820.1 - 0.01 16.0 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Kinetochore component CENP-S TFIID-31kDa PF02291.10 ESL06820.1 - 0.032 14.0 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit UPF0179 PF03684.8 ESL06820.1 - 0.089 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0179) Ras PF00071.17 ESL06821.1 - 7.5e-52 174.9 0.0 8.7e-52 174.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL06821.1 - 1.2e-16 61.2 0.0 1.8e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL06821.1 - 1.5e-12 47.1 0.0 1.8e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.1 ESL06821.1 - 4.3e-05 23.5 0.3 0.00054 19.9 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 ESL06821.1 - 5.7e-05 22.8 0.0 9.7e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DUF258 PF03193.11 ESL06821.1 - 0.00012 21.3 0.0 0.00019 20.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESL06821.1 - 0.00014 22.0 0.0 0.00047 20.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.7 ESL06821.1 - 0.0002 20.5 0.0 0.00034 19.8 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL06821.1 - 0.00029 20.7 0.0 0.00048 20.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESL06821.1 - 0.00064 18.9 0.0 0.0012 18.1 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 ESL06821.1 - 0.00089 18.9 0.1 0.0014 18.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 ESL06821.1 - 0.0018 17.7 0.0 0.005 16.3 0.0 1.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 ESL06821.1 - 0.0068 16.7 0.0 0.0091 16.2 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_5 PF07728.9 ESL06821.1 - 0.011 15.4 0.0 0.028 14.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESL06821.1 - 0.014 15.6 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 ESL06821.1 - 0.02 14.3 0.0 0.6 9.5 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain cobW PF02492.14 ESL06821.1 - 0.035 13.5 0.0 0.57 9.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.13 ESL06821.1 - 0.044 13.3 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family KAP_NTPase PF07693.9 ESL06821.1 - 0.047 12.6 0.0 0.071 12.0 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain IstB_IS21 PF01695.12 ESL06821.1 - 0.052 12.9 0.0 0.063 12.6 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein UPF0079 PF02367.12 ESL06821.1 - 0.056 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 FeoB_N PF02421.13 ESL06821.1 - 0.06 12.6 0.0 4.2 6.6 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_28 PF13521.1 ESL06821.1 - 0.061 13.2 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_32 PF13654.1 ESL06821.1 - 0.072 11.7 0.0 0.13 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESL06821.1 - 0.074 12.9 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain Septin PF00735.13 ESL06821.1 - 0.078 11.9 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Septin G-alpha PF00503.15 ESL06821.1 - 0.09 11.4 0.2 7.8 5.0 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit RNA_helicase PF00910.17 ESL06821.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.20 ESL06821.1 - 0.1 12.0 0.0 0.13 11.7 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MobB PF03205.9 ESL06821.1 - 0.12 12.0 0.1 0.5 10.0 0.0 1.9 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 ESL06821.1 - 0.14 12.3 0.0 0.34 11.0 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESL06821.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain SET PF00856.23 ESL06822.1 - 7.3e-11 42.6 0.0 1.9e-10 41.2 0.0 1.7 1 0 0 1 1 1 1 SET domain WD40 PF00400.27 ESL06823.1 - 5.8e-05 22.8 7.0 0.056 13.3 0.0 5.0 6 0 0 6 6 6 2 WD domain, G-beta repeat PQQ_3 PF13570.1 ESL06823.1 - 0.47 10.7 5.1 1.5 9.1 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain DUF4058 PF13267.1 ESL06824.1 - 0.027 13.6 1.3 0.088 11.9 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4058) Ribosomal_L24e PF01246.15 ESL06825.1 - 6.1e-31 106.1 1.7 6.1e-31 106.1 1.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e zf-FCS PF06467.9 ESL06825.1 - 0.11 12.1 5.6 0.19 11.3 3.9 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-ribbon_3 PF13248.1 ESL06825.1 - 0.3 10.3 2.2 0.53 9.5 1.6 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Atg14 PF10186.4 ESL06825.1 - 2.6 6.8 12.2 3 6.7 8.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Pro_isomerase PF00160.16 ESL06826.1 - 2e-20 73.5 0.1 2.4e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Kinesin PF00225.18 ESL06827.1 - 4.4e-90 301.7 0.1 4.4e-90 301.7 0.1 3.7 4 1 0 4 4 4 1 Kinesin motor domain Urm1 PF09138.6 ESL06828.1 - 5.7e-29 100.0 0.0 6.4e-29 99.9 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 ESL06828.1 - 1.6e-05 25.2 0.0 2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 ThiS family cwf21 PF08312.7 ESL06829.1 - 0.073 12.9 3.0 0.093 12.5 0.1 2.3 2 0 0 2 2 2 0 cwf21 domain Aldedh PF00171.17 ESL06830.1 - 1.2e-98 330.5 0.0 1.4e-98 330.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_L2_C PF03947.13 ESL06831.1 - 1.9e-40 137.6 1.7 3.9e-40 136.6 1.0 1.6 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 ESL06831.1 - 2.5e-14 53.0 0.0 6.1e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain HALZ PF02183.13 ESL06832.1 - 2e-05 24.2 0.2 4e-05 23.2 0.2 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.10 ESL06832.1 - 0.0067 15.8 0.4 0.049 13.1 0.0 2.0 2 0 0 2 2 2 1 Septum formation initiator DivIVA PF05103.8 ESL06832.1 - 0.017 15.1 1.2 0.021 14.8 0.2 1.7 1 1 1 2 2 2 0 DivIVA protein Kinetocho_Slk19 PF12709.2 ESL06832.1 - 0.033 14.2 0.4 0.04 13.9 0.3 1.2 1 0 0 1 1 1 0 Central kinetochore-associated DUF2594 PF10769.4 ESL06832.1 - 0.04 13.9 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2594) EcoEI_R_C PF08463.5 ESL06832.1 - 0.056 13.2 0.1 0.081 12.7 0.0 1.2 1 1 0 1 1 1 0 EcoEI R protein C-terminal Dpy-30 PF05186.8 ESL06832.1 - 0.063 12.7 0.4 0.17 11.4 0.3 1.7 1 1 0 1 1 1 0 Dpy-30 motif Antimicrobial20 PF08256.6 ESL06832.1 - 0.17 12.3 1.0 0.32 11.4 0.7 1.5 1 0 0 1 1 1 0 Aurein-like antibiotic peptide bZIP_2 PF07716.10 ESL06832.1 - 0.3 10.9 0.4 0.3 10.9 0.3 1.9 2 0 0 2 2 2 0 Basic region leucine zipper VIT1 PF01988.14 ESL06833.1 - 3.9e-29 101.6 3.5 4.5e-29 101.4 2.4 1.1 1 0 0 1 1 1 1 VIT family NIF PF03031.13 ESL06834.1 - 2.8e-29 101.8 0.0 5.1e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RXT2_N PF08595.6 ESL06834.1 - 0.045 13.5 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal ABC_tran PF00005.22 ESL06835.1 - 3e-31 108.5 0.0 8.1e-31 107.1 0.0 1.7 2 0 0 2 2 2 1 ABC transporter ABC2_membrane PF01061.19 ESL06835.1 - 1.6e-23 83.0 25.8 1.3e-22 79.9 12.8 3.0 3 0 0 3 3 3 2 ABC-2 type transporter AAA_21 PF13304.1 ESL06835.1 - 7e-07 29.4 0.0 0.015 15.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 ESL06835.1 - 0.00072 18.6 10.5 0.00072 18.6 7.3 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.1 ESL06835.1 - 0.00096 19.1 0.0 0.0022 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 ESL06835.1 - 0.0011 18.4 0.0 0.0027 17.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ESL06835.1 - 0.0032 16.6 0.0 0.0082 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_23 PF13476.1 ESL06835.1 - 0.0078 16.5 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESL06835.1 - 0.016 14.6 0.0 0.039 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESL06835.1 - 0.034 13.8 0.0 2.4 7.8 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase AAA_17 PF13207.1 ESL06835.1 - 0.044 14.6 0.1 0.11 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL06835.1 - 0.05 13.4 0.0 0.13 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 ESL06835.1 - 0.058 13.3 0.1 0.28 11.1 0.0 2.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ArgK PF03308.11 ESL06835.1 - 0.058 12.1 0.1 0.13 10.9 0.1 1.5 2 0 0 2 2 2 0 ArgK protein AAA_22 PF13401.1 ESL06835.1 - 0.059 13.5 0.1 0.18 11.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 ESL06835.1 - 0.11 11.9 0.2 0.19 11.1 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF3742 PF12553.3 ESL06835.1 - 4.4 7.8 6.1 0.93 10.0 0.1 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF3742) PriCT_2 PF08707.6 ESL06836.1 - 1.7e-16 59.8 0.3 3.4e-16 58.8 0.2 1.5 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) MADF_DNA_bdg PF10545.4 ESL06836.1 - 0.036 14.2 0.4 6.1 7.1 0.1 2.6 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Ribosomal_L24e PF01246.15 ESL06838.1 - 1.3e-13 50.5 0.6 1.3e-13 50.5 0.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e WW PF00397.21 ESL06839.1 - 1.1e-06 28.3 0.3 2.7e-06 27.1 0.2 1.7 1 0 0 1 1 1 1 WW domain M20_dimer PF07687.9 ESL06841.1 - 9.9e-19 67.1 0.0 2.3e-18 65.9 0.0 1.6 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESL06841.1 - 4.4e-09 36.1 0.1 5.3e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 zf-PHD-like PF15446.1 ESL06841.1 - 0.024 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain DUF1619 PF07773.6 ESL06843.1 - 3.3e-68 230.6 0.0 8.7e-66 222.7 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) tRNA_bind PF01588.15 ESL06844.1 - 1.9e-26 91.7 0.0 4.1e-26 90.6 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain WD40 PF00400.27 ESL06845.1 - 2.3e-53 176.2 15.1 1.4e-10 40.6 0.0 10.0 10 0 0 10 10 10 8 WD domain, G-beta repeat eIF2A PF08662.6 ESL06845.1 - 4.4e-08 33.0 0.0 0.0036 17.0 0.0 3.5 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 ESL06845.1 - 2.8e-05 22.1 0.3 0.00055 17.9 0.0 2.4 2 1 0 3 3 3 1 IKI3 family CPSF_A PF03178.10 ESL06845.1 - 0.011 14.8 0.0 0.6 9.1 0.0 3.1 3 2 0 3 3 3 0 CPSF A subunit region Apc4_WD40 PF12894.2 ESL06845.1 - 0.042 13.3 0.0 0.39 10.2 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain PPR_2 PF13041.1 ESL06848.1 - 5.5e-09 35.8 0.0 0.0019 18.1 0.0 3.7 3 1 1 4 4 4 3 PPR repeat family PPR PF01535.15 ESL06848.1 - 2.5e-07 30.2 0.1 0.002 17.9 0.0 3.5 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.1 ESL06848.1 - 1.9e-06 27.6 4.5 0.04 14.2 0.0 5.5 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESL06848.1 - 0.00013 21.3 0.7 0.00078 18.8 0.1 2.5 3 0 0 3 3 3 1 PPR repeat DEAD PF00270.24 ESL06849.1 - 7.7e-40 136.1 0.0 1.7e-37 128.5 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06849.1 - 6.4e-26 90.0 0.0 1.2e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06849.1 - 1.8e-06 27.8 0.0 1.6e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3322 PF11795.3 ESL06849.1 - 0.023 14.3 0.1 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) DUF2491 PF10679.4 ESL06849.1 - 0.12 11.3 0.2 0.2 10.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2491) YcgL PF05166.8 ESL06849.1 - 0.13 12.3 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 YcgL domain LRR_4 PF12799.2 ESL06851.1 - 0.00027 20.5 4.1 2 8.1 0.0 4.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) DUF972 PF06156.8 ESL06851.1 - 0.067 13.5 0.3 0.067 13.5 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF972) LRR_7 PF13504.1 ESL06851.1 - 0.18 12.0 8.6 40 5.0 0.0 6.4 7 0 0 7 7 7 0 Leucine rich repeat LRR_6 PF13516.1 ESL06851.1 - 0.26 11.4 3.1 9.5 6.6 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeat CSTF_C PF14304.1 ESL06852.1 - 1.5 8.1 7.3 0.081 12.2 1.0 2.0 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal DEAD PF00270.24 ESL06853.1 - 1.9e-39 134.8 0.0 4.5e-39 133.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06853.1 - 1.6e-20 72.7 0.0 8.7e-20 70.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06853.1 - 0.00012 21.9 0.2 0.0075 16.1 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Tub_2 PF04525.7 ESL06853.1 - 0.099 12.0 1.3 0.16 11.3 0.9 1.2 1 0 0 1 1 1 0 Tubby C 2 DUF2422 PF10337.4 ESL06853.1 - 1.6 7.4 4.6 2.1 7.0 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) PDEase_I PF00233.14 ESL06854.1 - 1.8e-61 207.9 0.2 2.5e-61 207.4 0.1 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.21 ESL06854.1 - 4e-42 143.9 0.1 1.3e-19 70.8 0.0 2.8 3 0 0 3 3 3 2 GAF domain GAF_2 PF13185.1 ESL06854.1 - 1.7e-15 57.7 0.1 5.3e-08 33.4 0.1 2.6 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.1 ESL06854.1 - 4.7e-15 55.8 0.0 2.4e-09 37.3 0.0 2.4 2 0 0 2 2 2 2 GAF domain DUF1546 PF07571.8 ESL06855.1 - 0.11 12.6 0.1 0.92 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1546) PDZ PF00595.19 ESL06856.1 - 0.073 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) TPR_11 PF13414.1 ESL06857.1 - 8.9e-17 60.5 13.2 7.9e-07 28.6 0.1 5.1 4 1 1 5 5 5 4 TPR repeat DnaJ PF00226.26 ESL06857.1 - 1.1e-12 47.5 0.1 2e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.23 ESL06857.1 - 6.6e-07 28.6 3.0 5.6 6.7 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06857.1 - 1.9e-06 28.4 18.3 0.17 12.5 0.1 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_15 PF13429.1 ESL06857.1 - 0.00017 20.7 0.1 0.00042 19.4 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL06857.1 - 0.00022 20.8 23.3 0.88 9.6 0.0 7.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL06857.1 - 0.00024 21.3 10.4 0.17 12.2 0.1 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL06857.1 - 0.0031 17.9 13.3 4.1 8.3 0.0 6.4 5 1 1 6 6 6 2 Tetratricopeptide repeat MIT PF04212.13 ESL06857.1 - 0.016 15.0 0.1 0.1 12.4 0.0 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Cohesin_HEAT PF12765.2 ESL06857.1 - 0.056 13.4 0.0 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion TPR_17 PF13431.1 ESL06857.1 - 0.1 12.8 0.7 21 5.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06857.1 - 0.2 11.6 5.6 19 5.2 0.0 4.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Peptidase_C2 PF00648.16 ESL06858.1 - 2.8e-18 65.9 0.0 6.2e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 ESL06858.1 - 0.05 13.2 0.4 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 Calpain large subunit, domain III DUF525 PF04379.9 ESL06859.1 - 1.8e-29 101.4 0.0 4.2e-29 100.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF525) His_Phos_2 PF00328.17 ESL06860.1 - 1.4e-14 54.2 0.0 3.8e-11 42.9 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) AWPM-19 PF05512.6 ESL06861.1 - 0.00075 19.5 0.6 0.00075 19.5 0.4 1.7 2 0 0 2 2 2 1 AWPM-19-like family EamA PF00892.15 ESL06861.1 - 0.0013 18.7 12.6 0.0031 17.5 7.9 2.2 1 1 1 2 2 2 1 EamA-like transporter family TPT PF03151.11 ESL06861.1 - 0.43 10.2 6.8 1.2 8.7 4.7 1.9 1 1 0 1 1 1 0 Triose-phosphate Transporter family EmrE PF13536.1 ESL06861.1 - 2 8.6 15.6 0.89 9.7 8.1 2.1 1 1 1 2 2 2 0 Multidrug resistance efflux transporter DUF1304 PF06993.7 ESL06861.1 - 4.1 7.1 8.8 4.3 7.0 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1304) DTW PF03942.10 ESL06862.1 - 1.9e-27 95.7 0.0 3.3e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 DTW domain zf-B_box PF00643.19 ESL06862.1 - 0.021 14.6 1.4 0.039 13.8 0.9 1.5 1 0 0 1 1 1 0 B-box zinc finger zf-RING_3 PF14369.1 ESL06862.1 - 0.15 12.0 1.7 0.19 11.7 0.3 1.9 2 0 0 2 2 2 0 zinc-finger zf-dskA_traR PF01258.12 ESL06862.1 - 0.38 10.5 4.3 0.13 12.0 1.2 1.6 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger PAP2 PF01569.16 ESL06863.1 - 6.6e-23 80.7 1.0 6.6e-23 80.7 0.7 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 ESL06863.1 - 0.014 14.9 2.7 0.06 12.8 0.6 2.6 2 1 0 2 2 2 0 PAP2 superfamily AMOP PF03782.12 ESL06863.1 - 0.054 13.4 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 AMOP domain DUF1772 PF08592.6 ESL06863.1 - 0.29 10.8 3.9 2.6 7.7 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF4117 PF13491.1 ESL06863.1 - 3.9 6.8 9.9 0.31 10.4 0.8 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4117) Metallophos PF00149.23 ESL06865.1 - 2.3e-27 95.6 0.5 3.2e-27 95.2 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ClpB_D2-small PF10431.4 ESL06866.1 - 2.6e-23 81.7 0.0 3.8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_2 PF07724.9 ESL06866.1 - 0.00056 19.8 0.0 0.00099 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) LacI PF00356.16 ESL06866.1 - 0.038 13.6 0.5 0.083 12.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Aldose_epim PF01263.15 ESL06868.1 - 1.1e-50 172.5 0.0 1.3e-50 172.2 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase WD40 PF00400.27 ESL06869.1 - 1.5e-82 268.8 24.6 1.1e-11 44.1 0.0 8.4 8 1 0 8 8 8 8 WD domain, G-beta repeat Nup160 PF11715.3 ESL06869.1 - 9.6e-09 33.9 2.9 0.0022 16.2 0.0 4.2 1 1 3 4 4 4 3 Nucleoporin Nup120/160 eIF2A PF08662.6 ESL06869.1 - 7.6e-06 25.7 0.0 0.098 12.3 0.0 3.3 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 ESL06869.1 - 3.7e-05 23.2 3.7 7.2 6.3 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.1 ESL06869.1 - 8.5e-05 21.7 0.3 0.78 8.7 0.0 3.5 2 2 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.4 ESL06869.1 - 0.0096 15.3 0.9 0.032 13.6 0.0 2.1 2 0 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.4 ESL06869.1 - 1.9 7.9 3.5 98 2.4 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Arf PF00025.16 ESL06871.1 - 7.6e-08 31.7 0.0 1.3e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family ABC_tran PF00005.22 ESL06871.1 - 0.00036 20.8 0.0 0.00038 20.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 ESL06871.1 - 0.0019 18.3 0.0 0.0025 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 ESL06871.1 - 0.0019 17.8 0.0 0.0024 17.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL06871.1 - 0.0039 17.1 0.1 0.0059 16.6 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain Miro PF08477.8 ESL06871.1 - 0.0046 17.4 0.0 0.0063 16.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein ATP_bind_1 PF03029.12 ESL06871.1 - 0.0061 16.1 0.0 0.1 12.1 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Arch_ATPase PF01637.13 ESL06871.1 - 0.0064 16.2 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase NACHT PF05729.7 ESL06871.1 - 0.0065 16.1 0.0 0.04 13.5 0.0 2.2 3 0 0 3 3 3 1 NACHT domain AAA_5 PF07728.9 ESL06871.1 - 0.027 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESL06871.1 - 0.035 13.9 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESL06871.1 - 0.042 13.4 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESL06871.1 - 0.047 13.3 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_21 PF13304.1 ESL06871.1 - 0.076 12.9 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL06871.1 - 0.077 13.3 0.0 0.1 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.15 ESL06871.1 - 0.1 11.2 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_28 PF13521.1 ESL06871.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 ESL06871.1 - 0.14 11.6 0.0 0.5 9.8 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 ESL06871.1 - 0.15 11.2 0.0 0.3 10.3 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_PrkA PF08298.6 ESL06871.1 - 0.16 10.6 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain RNA_pol_Rpb1_1 PF04997.7 ESL06872.1 - 1.6e-99 333.3 0.2 4e-99 332.0 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 ESL06872.1 - 6.2e-85 284.7 0.0 1.5e-84 283.5 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ESL06872.1 - 9.2e-65 217.6 0.2 2.7e-64 216.1 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 ESL06872.1 - 1.1e-42 145.8 0.6 2.2e-42 144.9 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 ESL06872.1 - 4.1e-42 143.5 0.0 1e-41 142.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESL06872.1 - 7.7e-28 96.3 0.1 2.3e-27 94.8 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_7 PF04990.7 ESL06872.1 - 2.9e-27 95.0 0.7 2.9e-27 95.0 0.5 2.3 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 7 PspA_IM30 PF04012.7 ESL06872.1 - 0.045 13.1 2.3 0.097 12.0 1.6 1.4 1 0 0 1 1 1 0 PspA/IM30 family Mitovir_RNA_pol PF05919.6 ESL06872.1 - 0.089 11.7 0.1 0.18 10.7 0.1 1.4 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase AAA_18 PF13238.1 ESL06873.1 - 0.061 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain 2OG-FeII_Oxy PF03171.15 ESL06874.1 - 2.6e-13 50.0 0.0 5.3e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 ESL06874.1 - 0.00078 19.9 0.0 0.37 11.3 0.0 2.8 3 0 0 3 3 3 2 non-haem dioxygenase in morphine synthesis N-terminal Gaa1 PF04114.9 ESL06875.1 - 5.9e-05 21.9 0.7 9.6e-05 21.2 0.5 1.4 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component MFS_1 PF07690.11 ESL06877.1 - 9.6e-24 83.7 30.5 5.6e-17 61.4 4.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESL06877.1 - 1e-15 57.3 31.1 2.9e-15 55.8 21.5 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.15 ESL06877.1 - 4e-11 41.6 11.9 1.2e-08 33.5 0.2 3.2 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family zf-CSL PF05207.8 ESL06878.1 - 1.6e-16 59.5 0.4 2e-16 59.2 0.3 1.2 1 0 0 1 1 1 1 CSL zinc finger PALP PF00291.20 ESL06879.1 - 2.7e-40 138.5 0.0 3.2e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Bmp PF02608.9 ESL06879.1 - 0.04 12.6 0.0 3.9 6.1 0.0 2.1 2 0 0 2 2 2 0 Basic membrane protein Sec16_C PF12931.2 ESL06880.1 - 9.7e-16 58.3 0.0 1.7e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Ribosomal_L21e PF01157.13 ESL06883.1 - 2.1e-36 123.6 2.3 3e-36 123.1 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e 2OG-FeII_Oxy_3 PF13640.1 ESL06884.1 - 4.8e-14 52.6 0.0 8.9e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 ESL06884.1 - 3.7e-05 23.2 0.0 6.7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.8 ESL06884.1 - 0.00039 20.5 0.0 0.0016 18.5 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Pox_C4_C10 PF03336.8 ESL06884.1 - 0.0019 17.0 0.0 0.0033 16.2 0.0 1.5 2 0 0 2 2 2 1 Poxvirus C4/C10 protein TPR_6 PF13174.1 ESL06884.1 - 0.078 13.4 0.1 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Cir_N PF10197.4 ESL06885.1 - 0.002 18.0 3.2 0.002 18.0 2.2 3.2 3 1 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR YliH PF10799.3 ESL06885.1 - 0.057 13.1 0.2 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) CENP-Q PF13094.1 ESL06885.1 - 1.4 8.9 12.0 0.077 13.0 0.8 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Host_attach PF10116.4 ESL06885.1 - 1.9 8.7 8.6 0.2 11.8 0.8 2.5 2 1 0 2 2 2 0 Protein required for attachment to host cells DUF2381 PF09544.5 ESL06885.1 - 2.9 6.9 8.9 0.54 9.3 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) Peptidase_S8 PF00082.17 ESL06886.1 - 2.4e-17 63.0 0.0 6.6e-17 61.5 0.0 1.8 2 0 0 2 2 2 1 Subtilase family CUB PF00431.15 ESL06886.1 - 2.9e-11 43.4 0.0 7.4e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 CUB domain EGF_2 PF07974.8 ESL06886.1 - 0.0075 16.4 12.7 0.0075 16.4 8.8 5.6 4 1 1 5 5 5 4 EGF-like domain Ribosomal_L21p PF00829.16 ESL06887.1 - 1.3e-18 66.8 0.0 1.9e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Ras PF00071.17 ESL06888.1 - 8.7e-37 126.0 0.0 1.1e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL06888.1 - 1.6e-20 73.8 0.0 2.3e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL06888.1 - 1.5e-16 60.1 0.0 3.4e-16 58.9 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL06888.1 - 0.00019 20.6 0.0 0.00029 20.0 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL06888.1 - 0.00089 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 ESL06888.1 - 0.0026 16.4 0.0 0.015 13.9 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.4 ESL06888.1 - 0.014 14.8 0.0 0.033 13.6 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 ESL06888.1 - 0.1 12.4 0.0 1.3 8.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESL06888.1 - 0.15 11.9 0.0 0.72 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain DUF89 PF01937.14 ESL06889.1 - 4.4e-41 140.8 0.0 9.8e-32 110.1 0.0 5.1 4 1 0 4 4 4 4 Protein of unknown function DUF89 Put_Phosphatase PF06888.7 ESL06889.1 - 8.9e-33 113.4 0.0 2.5e-32 111.9 0.0 1.8 1 1 0 1 1 1 1 Putative Phosphatase HAD PF12710.2 ESL06889.1 - 3.8e-05 23.9 0.0 0.00012 22.3 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CTP_transf_2 PF01467.21 ESL06891.1 - 1.2e-32 113.1 0.1 3.8e-17 62.7 0.1 2.6 2 1 0 2 2 2 2 Cytidylyltransferase FAD_syn PF06574.7 ESL06891.1 - 0.00014 21.5 1.0 0.56 9.8 0.0 3.5 2 1 0 2 2 2 2 FAD synthetase DUF2294 PF10057.4 ESL06891.1 - 0.098 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) FAD-oxidase_C PF02913.14 ESL06892.1 - 5.7e-43 147.0 0.0 1.8e-42 145.3 0.0 1.7 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 ESL06892.1 - 5.6e-09 35.6 2.0 1.5e-08 34.2 0.9 2.1 2 0 0 2 2 2 1 FAD binding domain SET PF00856.23 ESL06893.1 - 2.1e-06 28.1 0.0 5.4e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 SET domain Ribosomal_L24e PF01246.15 ESL06894.1 - 7.8e-14 51.2 0.5 7.8e-14 51.2 0.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e WD40 PF00400.27 ESL06895.1 - 1e-49 164.6 13.3 6.1e-11 41.7 0.1 10.2 10 0 0 10 10 10 8 WD domain, G-beta repeat Utp13 PF08625.6 ESL06895.1 - 1e-40 138.6 0.9 1.7e-40 137.9 0.4 1.5 2 0 0 2 2 2 1 Utp13 specific WD40 associated domain Utp12 PF04003.7 ESL06895.1 - 0.00018 21.3 0.7 0.00032 20.5 0.5 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family UTP15_C PF09384.5 ESL06895.1 - 0.0003 20.5 0.6 0.00058 19.5 0.4 1.4 1 0 0 1 1 1 1 UTP15 C terminal Nucleoporin_N PF08801.6 ESL06895.1 - 0.0018 17.1 0.0 0.24 10.0 0.0 3.6 2 1 1 3 3 3 1 Nup133 N terminal like Cytochrom_D1 PF02239.11 ESL06895.1 - 0.094 10.9 0.0 0.55 8.4 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain TT_ORF2 PF02957.10 ESL06897.1 - 0.045 14.4 4.1 0.15 12.7 0.1 3.0 2 1 1 3 3 3 0 TT viral ORF2 CTP_transf_2 PF01467.21 ESL06897.1 - 0.16 12.0 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase Motile_Sperm PF00635.21 ESL06899.1 - 0.00053 19.6 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PPR_2 PF13041.1 ESL06900.1 - 8.5e-05 22.4 2.4 0.012 15.5 0.0 2.5 2 1 0 2 2 2 2 PPR repeat family RPM2 PF08579.6 ESL06900.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) TFIIS_C PF01096.13 ESL06901.1 - 3.5e-16 58.5 3.5 3.5e-16 58.5 2.4 2.9 3 1 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 ESL06901.1 - 1.9e-07 30.6 1.3 7.5e-07 28.7 0.1 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.7 ESL06901.1 - 9.8e-06 24.7 0.2 0.018 14.3 0.2 2.6 2 0 0 2 2 2 2 TFIIB zinc-binding DZR PF12773.2 ESL06901.1 - 0.045 13.5 5.3 0.084 12.7 0.2 2.4 2 1 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 ESL06901.1 - 0.054 13.3 6.3 0.25 11.1 0.3 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Baculo_LEF5_C PF11792.3 ESL06901.1 - 0.089 12.1 0.2 0.089 12.1 0.1 1.8 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain Runt PF00853.14 ESL06901.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Runt domain OrfB_Zn_ribbon PF07282.6 ESL06901.1 - 0.14 11.8 4.7 4.2 7.1 0.4 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.1 ESL06901.1 - 0.21 10.8 0.5 0.21 10.8 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain DUF2296 PF10058.4 ESL06901.1 - 0.26 11.0 5.0 5 6.9 0.0 3.2 3 0 0 3 3 3 0 Predicted integral membrane metal-binding protein (DUF2296) zf-piccolo PF05715.8 ESL06901.1 - 0.48 10.4 4.9 0.28 11.2 0.7 2.4 2 1 0 2 2 2 0 Piccolo Zn-finger Nudix_N_2 PF14803.1 ESL06901.1 - 0.58 9.8 6.9 0.51 10.0 2.0 2.6 2 1 0 2 2 2 0 Nudix N-terminal UPF0547 PF10571.4 ESL06901.1 - 0.64 9.7 6.8 2.1 8.1 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 IBR PF01485.16 ESL06901.1 - 2.1 8.2 6.6 5.8 6.8 0.1 2.7 2 1 0 2 2 2 0 IBR domain zf-Mss51 PF13824.1 ESL06901.1 - 2.2 8.1 5.7 15 5.4 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-H2C2_2 PF13465.1 ESL06901.1 - 5.1 7.5 9.2 4.3 7.8 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain RabGAP-TBC PF00566.13 ESL06902.1 - 6.6e-50 169.5 0.0 8.2e-50 169.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Glyco_tran_WecB PF03808.8 ESL06902.1 - 0.024 14.0 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family CRA_rpt PF07046.6 ESL06904.1 - 0.14 12.1 2.7 0.28 11.2 1.9 1.4 1 0 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat AsnA PF03590.10 ESL06905.1 - 7.8e-103 343.1 0.1 8.3e-102 339.7 0.1 2.0 1 1 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.15 ESL06905.1 - 0.0001 21.2 0.0 0.0042 15.8 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II (D, K and N) DUF4392 PF14336.1 ESL06905.1 - 0.16 10.7 0.0 0.27 9.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) RMP PF14996.1 ESL06907.1 - 2.3e-08 34.0 5.4 2.3e-08 34.0 3.7 2.3 2 1 0 2 2 2 1 Retinal Maintenance Aa_trans PF01490.13 ESL06908.1 - 2.1e-40 138.4 24.7 2.9e-40 138.0 17.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EMP70 PF02990.11 ESL06909.1 - 2.4e-122 409.0 0.1 2.9e-122 408.7 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 PUB PF09409.5 ESL06911.1 - 2.9e-12 46.1 0.0 5.9e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 PUB domain DUF3005 PF11448.3 ESL06911.1 - 0.0082 15.7 0.0 0.035 13.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3005) Glyco_hydro_47 PF01532.15 ESL06912.1 - 1.3e-115 386.6 0.0 1.7e-115 386.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4159 PF13709.1 ESL06912.1 - 0.15 11.2 0.0 0.29 10.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) DEAD PF00270.24 ESL06913.1 - 4.1e-29 101.2 0.1 2.4e-14 53.1 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL06913.1 - 3.6e-13 49.1 0.0 8.1e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL06913.1 - 3.5e-09 36.7 0.0 1.6e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESL06913.1 - 0.02 15.0 0.3 2.6 8.1 0.4 2.9 2 1 0 2 2 2 0 AAA domain Flavi_DEAD PF07652.9 ESL06913.1 - 0.044 13.5 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain PilJ PF13675.1 ESL06914.1 - 5.3 7.4 6.3 1.7 8.9 2.2 1.9 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pyr_redox_2 PF07992.9 ESL06915.1 - 9.6e-27 94.1 0.0 2e-26 93.1 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESL06915.1 - 9.5e-17 61.0 0.1 2.8e-16 59.5 0.0 1.9 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ESL06915.1 - 3.7e-13 49.6 2.0 2e-10 40.8 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESL06915.1 - 1.7e-09 38.0 0.1 4.8e-09 36.5 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESL06915.1 - 2.3e-08 33.5 0.7 9.4e-08 31.5 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 ESL06915.1 - 4.5e-07 29.0 0.3 0.00018 20.4 0.1 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESL06915.1 - 5.8e-07 29.4 0.9 0.0022 17.9 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 ESL06915.1 - 1.8e-06 26.7 0.6 0.0002 19.9 0.1 2.7 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.19 ESL06915.1 - 2.3e-05 23.4 4.3 0.0018 17.2 0.2 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 ESL06915.1 - 0.0003 19.8 0.2 0.052 12.4 0.0 3.1 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 ESL06915.1 - 0.00031 19.7 1.6 0.0045 15.8 0.1 2.8 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.12 ESL06915.1 - 0.00049 19.2 0.1 0.011 14.8 0.0 2.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 ESL06915.1 - 0.00095 18.3 0.3 0.29 10.1 0.0 3.1 3 0 0 3 3 3 1 FAD binding domain 3HCDH_N PF02737.13 ESL06915.1 - 0.0033 17.0 3.3 0.026 14.1 0.0 2.7 3 0 0 3 3 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 ESL06915.1 - 0.0046 16.7 0.1 0.022 14.5 0.0 2.1 2 0 0 2 2 2 1 ThiF family K_oxygenase PF13434.1 ESL06915.1 - 0.007 15.3 0.0 0.033 13.0 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.14 ESL06915.1 - 0.024 13.8 0.0 0.17 10.9 0.0 2.3 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 ESL06915.1 - 0.066 13.4 0.1 2.5 8.3 0.0 2.9 2 1 0 2 2 2 0 Putative NAD(P)-binding RRM_1 PF00076.17 ESL06917.1 - 1.4e-18 66.3 0.0 1.9e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL06917.1 - 9.3e-12 44.7 0.0 1.4e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL06917.1 - 4.7e-11 42.3 0.0 6.8e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L44 PF00935.14 ESL06918.1 - 1.3e-31 108.3 8.0 2e-31 107.8 5.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 RNHCP PF12647.2 ESL06918.1 - 0.17 11.6 2.8 0.35 10.7 0.1 2.0 1 1 1 2 2 2 0 RNHCP domain UPF0020 PF01170.13 ESL06919.1 - 2.1e-14 53.5 0.1 5.9e-10 39.0 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 ESL06919.1 - 5.4e-13 49.0 0.2 2.4e-12 46.9 0.1 2.2 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 ESL06919.1 - 1.6e-05 24.5 0.0 0.00074 19.0 0.0 2.2 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.11 ESL06919.1 - 0.0011 18.1 0.0 0.021 13.9 0.0 2.4 2 1 0 3 3 3 1 N-6 DNA Methylase Choline_kinase PF01633.15 ESL06920.1 - 1.6e-22 80.1 0.0 3.1e-22 79.2 0.0 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESL06920.1 - 5.2e-10 39.4 0.1 1.2e-09 38.2 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESL06920.1 - 0.049 12.7 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain SecE PF00584.15 ESL06922.1 - 5.2e-11 41.9 0.3 6.3e-11 41.6 0.2 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CobD_Cbib PF03186.8 ESL06922.1 - 0.048 12.7 0.1 0.051 12.6 0.0 1.0 1 0 0 1 1 1 0 CobD/Cbib protein GDPD PF03009.12 ESL06923.1 - 4.2e-25 88.7 0.9 3e-21 76.0 0.6 3.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family BBS2_N PF14781.1 ESL06924.1 - 0.0036 16.9 0.2 0.73 9.4 0.0 3.1 2 2 1 3 3 3 2 Ciliary BBSome complex subunit 2, N-terminal LRR_4 PF12799.2 ESL06926.1 - 0.11 12.1 0.1 7.1 6.3 0.0 3.0 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF789 PF05623.7 ESL06927.1 - 1.8e-07 30.9 0.1 1.8e-07 30.9 0.1 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF789) 7TMR-DISM_7TM PF07695.6 ESL06928.1 - 0.027 14.1 0.9 0.033 13.8 0.6 1.3 1 1 0 1 1 1 0 7TM diverse intracellular signalling SPC25 PF06703.6 ESL06928.1 - 0.057 12.9 0.0 0.66 9.5 0.0 2.1 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) WTF PF03303.8 ESL06928.1 - 0.068 12.5 0.2 0.088 12.2 0.1 1.1 1 0 0 1 1 1 0 WTF protein DUF378 PF04070.7 ESL06928.1 - 0.092 12.3 0.1 0.19 11.3 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF378) DUF4131 PF13567.1 ESL06928.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PrgI PF12666.2 ESL06928.1 - 0.16 12.1 0.6 0.26 11.4 0.4 1.3 1 0 0 1 1 1 0 PrgI family protein HSP70 PF00012.15 ESL06929.1 - 3.9e-52 176.9 0.1 4.5e-52 176.7 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein PALP PF00291.20 ESL06933.1 - 1.7e-29 103.0 3.3 2e-29 102.8 2.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TRAPP PF04051.11 ESL06934.1 - 0.00057 19.4 0.0 0.00068 19.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component FAM194 PF14977.1 ESL06934.1 - 0.11 11.4 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 FAM194 protein Metallophos PF00149.23 ESL06935.1 - 1.7e-38 132.0 0.1 2e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sec63 PF02889.11 ESL06936.1 - 3.8e-42 144.6 0.0 5.2e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.26 ESL06936.1 - 0.0022 17.8 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 ESL06936.1 - 0.038 14.1 0.1 0.089 12.9 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain BphX PF06139.7 ESL06937.1 - 0.021 14.3 0.0 0.059 12.9 0.0 1.7 1 0 0 1 1 1 0 BphX-like MORN PF02493.15 ESL06939.1 - 2.5e-19 67.7 12.9 1.2e-06 27.8 0.1 4.7 4 0 0 4 4 4 4 MORN repeat Ferrochelatase PF00762.14 ESL06940.1 - 0.09 11.7 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Ferrochelatase Vps16_C PF04840.7 ESL06942.1 - 1.2e-22 80.2 0.0 4.5e-17 61.9 0.0 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region Vps16_N PF04841.8 ESL06942.1 - 3.9e-22 78.3 0.0 9.6e-15 54.0 0.0 2.4 2 1 0 2 2 2 2 Vps16, N-terminal region PseudoU_synth_2 PF00849.17 ESL06945.1 - 6.9e-24 84.5 0.6 1.8e-23 83.1 0.4 1.7 1 1 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_S9_N PF02897.10 ESL06947.1 - 4.3e-97 325.3 0.0 5.1e-97 325.0 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.16 ESL06947.1 - 1.1e-64 217.6 0.0 2e-64 216.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.15 ESL06947.1 - 3.6e-05 23.3 0.0 6.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 ESL06947.1 - 0.00036 20.2 0.0 0.00079 19.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 ESL06947.1 - 0.0041 16.8 0.0 0.0066 16.1 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.13 ESL06947.1 - 0.0083 15.5 0.6 0.18 11.1 0.0 2.4 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 ESL06947.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 ESL06947.1 - 0.079 12.5 0.0 0.18 11.3 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold ParA PF10609.4 ESL06948.1 - 4.1e-35 119.5 0.1 8.3e-35 118.5 0.0 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESL06948.1 - 1.2e-15 57.4 0.1 1.7e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 ESL06948.1 - 6.6e-09 35.2 1.2 4.2e-08 32.5 0.8 1.9 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.13 ESL06948.1 - 6.7e-06 25.4 0.1 0.0029 16.8 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_31 PF13614.1 ESL06948.1 - 1.9e-05 24.6 0.1 0.00016 21.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 ESL06948.1 - 0.00022 20.3 2.1 0.00032 19.8 0.3 2.0 2 1 0 2 2 2 1 Anion-transporting ATPase VirC1 PF07015.6 ESL06948.1 - 0.00047 19.2 0.1 0.00094 18.3 0.1 1.5 1 0 0 1 1 1 1 VirC1 protein YhjQ PF06564.7 ESL06948.1 - 0.039 13.3 0.2 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 YhjQ protein AAA_26 PF13500.1 ESL06948.1 - 0.12 11.9 0.1 8 6.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sdh5 PF03937.11 ESL06949.1 - 4.7e-22 77.4 0.2 1.1e-21 76.2 0.1 1.7 1 1 0 1 1 1 1 Flavinator of succinate dehydrogenase Macoilin PF09726.4 ESL06950.1 - 1.8 6.7 8.7 3.1 5.9 6.0 1.3 1 0 0 1 1 1 0 Transmembrane protein Glycos_transf_1 PF00534.15 ESL06951.1 - 5.1e-16 58.5 0.0 7.5e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESL06951.1 - 2e-11 44.1 0.0 4.4e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 ESL06951.1 - 7.8e-10 39.1 2.3 7.8e-10 39.1 1.6 2.3 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 ESL06951.1 - 2.7e-09 36.9 3.1 1.6e-08 34.4 2.1 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 ESL06951.1 - 2.1e-06 27.9 0.0 6e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 BSD PF03909.12 ESL06952.1 - 1.2e-07 31.3 0.0 3e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 BSD domain Sec7 PF01369.15 ESL06953.1 - 4e-46 157.0 0.0 7.9e-46 156.1 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESL06953.1 - 0.00013 21.4 2.9 0.026 13.9 0.2 3.4 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Mito_carr PF00153.22 ESL06954.1 - 4.8e-22 77.4 5.4 6.1e-10 38.6 0.3 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Metallophos PF00149.23 ESL06955.1 - 2.9e-44 150.8 0.2 3.5e-44 150.5 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1448 PF07289.6 ESL06956.1 - 1.6e-125 418.5 0.0 1.8e-125 418.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1448) Vps36_ESCRT-II PF11605.3 ESL06956.1 - 0.063 13.0 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 Voldacs PF03517.8 ESL06956.1 - 0.086 12.6 0.1 0.73 9.6 0.0 2.1 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling TPR_11 PF13414.1 ESL06957.1 - 4.1e-06 26.3 1.4 9.8e-06 25.1 0.2 2.1 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 ESL06957.1 - 0.00011 21.7 3.2 0.027 14.3 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL06957.1 - 0.00088 19.8 2.6 0.0026 18.3 1.8 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL06957.1 - 0.0015 18.0 1.2 0.0057 16.2 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL06957.1 - 0.031 14.1 3.0 0.04 13.8 0.5 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2153 PF09921.4 ESL06957.1 - 0.067 12.8 0.3 0.15 11.7 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) Pap_E4 PF02711.9 ESL06957.1 - 0.45 11.3 1.9 0.86 10.4 1.3 1.4 1 0 0 1 1 1 0 E4 protein DUF1771 PF08590.5 ESL06957.1 - 2.1 8.3 6.6 0.3 11.1 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) SnoaL_2 PF12680.2 ESL06958.1 - 4.8e-06 26.9 0.4 1.8e-05 25.0 0.3 2.0 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.1 ESL06958.1 - 0.011 15.7 0.1 0.058 13.4 0.0 2.1 1 1 0 2 2 2 0 SnoaL-like domain DUF4440 PF14534.1 ESL06958.1 - 0.023 14.9 0.1 0.17 12.1 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) NTF2 PF02136.15 ESL06958.1 - 0.033 14.5 0.1 0.09 13.1 0.0 1.7 2 0 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain DUF1253 PF06862.7 ESL06960.1 - 3.7e-129 430.9 0.0 5.3e-129 430.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DEAD PF00270.24 ESL06960.1 - 0.02 14.3 0.0 0.54 9.7 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase CobA_CobO_BtuR PF02572.10 ESL06960.1 - 0.036 13.7 0.1 0.075 12.6 0.0 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP PIF1 PF05970.9 ESL06962.1 - 1.8e-38 132.4 0.1 6.9e-32 110.7 0.0 3.0 3 0 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 ESL06962.1 - 6.7e-11 42.1 0.0 1.4e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL06962.1 - 7.3e-06 26.1 0.0 2.6e-05 24.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain UvrD_C_2 PF13538.1 ESL06962.1 - 9.8e-06 25.6 0.0 4.9e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 ESL06962.1 - 1e-05 25.1 0.7 3.2e-05 23.6 0.5 1.9 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 ESL06962.1 - 0.00026 20.5 0.6 0.88 9.0 0.2 3.3 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 ESL06962.1 - 0.0031 16.5 0.1 0.0085 15.1 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Herpes_Helicase PF02689.9 ESL06962.1 - 0.0042 14.9 0.5 0.2 9.3 0.1 2.2 2 0 0 2 2 2 1 Helicase AAA_16 PF13191.1 ESL06962.1 - 0.0081 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Helicase_RecD PF05127.9 ESL06962.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Helicase AAA_25 PF13481.1 ESL06962.1 - 0.017 14.5 0.9 0.64 9.3 0.1 2.4 1 1 1 2 2 2 0 AAA domain NACHT PF05729.7 ESL06962.1 - 0.048 13.3 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 ESL06962.1 - 0.081 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.13 ESL06962.1 - 0.13 11.8 0.0 0.5 9.9 0.0 1.8 2 0 0 2 2 2 0 Bacterial dnaA protein MobB PF03205.9 ESL06962.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B PhoH PF02562.11 ESL06962.1 - 0.15 11.2 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF853 PF05872.7 ESL06962.1 - 0.24 9.6 0.1 0.38 9.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Actin PF00022.14 ESL06963.1 - 2.9e-89 299.2 0.0 3.8e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Actin Pkinase PF00069.20 ESL06964.1 - 1.1e-34 119.7 0.0 1.9e-27 96.0 0.0 3.1 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESL06964.1 - 1.6e-14 53.6 0.0 1.7e-13 50.2 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL06964.1 - 0.0017 17.3 0.0 0.003 16.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.6 ESL06964.1 - 0.0026 16.6 0.1 0.0044 15.8 0.1 1.3 1 1 0 1 1 1 1 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.15 ESL06964.1 - 0.069 12.7 0.0 0.15 11.6 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase DnaJ PF00226.26 ESL06965.1 - 0.0074 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Hydrolase_6 PF13344.1 ESL06966.1 - 3.9e-19 68.3 0.0 7.8e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESL06966.1 - 4.1e-15 55.2 0.0 1e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ESL06966.1 - 5.3e-08 33.5 0.0 0.013 15.9 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESL06966.1 - 9.7e-06 25.9 0.0 0.0017 18.6 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 ESL06966.1 - 5.8e-05 22.5 0.0 0.00014 21.2 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase DNA_binding_1 PF01035.15 ESL06967.1 - 1.6e-27 95.0 0.1 2.2e-27 94.6 0.1 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain IFT57 PF10498.4 ESL06968.1 - 5.4e-126 420.1 0.9 6.3e-126 419.9 0.6 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 AAA_13 PF13166.1 ESL06968.1 - 0.0018 16.8 6.4 0.0025 16.3 4.4 1.1 1 0 0 1 1 1 1 AAA domain Tropomyosin PF00261.15 ESL06968.1 - 0.0021 17.2 10.5 0.0035 16.4 7.0 1.5 1 1 0 1 1 1 1 Tropomyosin DUF1978 PF09321.5 ESL06968.1 - 0.0054 16.2 6.5 0.01 15.3 4.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1978) AKNA PF12443.3 ESL06968.1 - 0.02 14.8 9.9 0.41 10.6 0.5 2.7 1 1 1 2 2 2 0 AT-hook-containing transcription factor DUF2408 PF10303.4 ESL06968.1 - 0.035 14.2 5.0 0.066 13.3 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) IncA PF04156.9 ESL06968.1 - 0.041 13.4 13.9 0.15 11.6 2.2 2.2 1 1 1 2 2 2 0 IncA protein Spc7 PF08317.6 ESL06968.1 - 0.045 12.4 9.5 0.077 11.6 6.6 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Fzo_mitofusin PF04799.8 ESL06968.1 - 0.046 13.0 6.2 0.074 12.4 4.0 1.6 1 1 0 1 1 1 0 fzo-like conserved region Reo_sigmaC PF04582.7 ESL06968.1 - 0.054 12.6 4.9 0.089 11.9 3.4 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 ESL06968.1 - 0.084 12.6 12.3 0.092 12.4 7.6 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.7 ESL06968.1 - 0.088 12.6 5.8 1.2 9.0 2.4 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCPsignal PF00015.16 ESL06968.1 - 0.088 12.3 6.8 0.066 12.7 2.2 1.9 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.7 ESL06968.1 - 0.088 12.5 12.2 0.56 9.9 7.4 2.5 1 1 1 2 2 2 0 Laminin Domain II CR6_interact PF10147.4 ESL06968.1 - 0.089 12.1 4.7 0.083 12.1 2.4 1.6 1 1 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 V_ATPase_I PF01496.14 ESL06968.1 - 0.098 10.5 7.3 0.13 10.1 5.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MutS_III PF05192.13 ESL06968.1 - 0.15 11.8 2.7 0.26 11.0 1.9 1.4 1 0 0 1 1 1 0 MutS domain III DUF4404 PF14357.1 ESL06968.1 - 0.18 12.2 7.0 2.2 8.7 1.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF1664 PF07889.7 ESL06968.1 - 0.2 11.4 10.7 0.85 9.4 1.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Mnd1 PF03962.10 ESL06968.1 - 0.23 11.1 10.0 0.54 9.9 6.9 1.6 1 1 0 1 1 1 0 Mnd1 family Apolipoprotein PF01442.13 ESL06968.1 - 0.23 10.9 14.7 0.66 9.4 10.2 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF745 PF05335.8 ESL06968.1 - 0.4 10.1 9.0 0.33 10.4 2.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) FUSC PF04632.7 ESL06968.1 - 0.44 8.9 2.1 0.6 8.4 1.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family COG2 PF06148.6 ESL06968.1 - 0.76 9.6 10.8 3.5 7.4 1.8 2.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 GAS PF13851.1 ESL06968.1 - 1.1 8.4 13.8 0.38 9.9 5.5 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.1 ESL06968.1 - 1.5 8.7 11.3 4 7.4 7.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF948 PF06103.6 ESL06968.1 - 1.7 8.5 10.1 0.33 10.8 1.9 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) CCDC-167 PF15188.1 ESL06968.1 - 1.7 8.6 5.5 0.72 9.8 0.5 2.6 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF342 PF03961.8 ESL06968.1 - 2 6.7 10.2 0.24 9.7 3.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DUF2203 PF09969.4 ESL06968.1 - 2.8 8.1 8.3 6.5 7.0 2.2 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Seryl_tRNA_N PF02403.17 ESL06968.1 - 3 7.8 10.4 8.5 6.4 6.4 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TBCA PF02970.11 ESL06968.1 - 4.7 7.3 11.5 8.1 6.5 1.5 2.8 1 1 1 2 2 2 0 Tubulin binding cofactor A OmpH PF03938.9 ESL06968.1 - 5 7.0 12.6 11 5.9 8.8 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) HEAT_2 PF13646.1 ESL06969.1 - 1.7e-11 44.2 4.3 0.24 11.6 0.1 5.8 6 2 1 7 7 7 4 HEAT repeats HEAT PF02985.17 ESL06969.1 - 1.4e-10 40.2 6.2 3.1 8.1 0.0 9.2 10 0 0 10 10 10 4 HEAT repeat IBN_N PF03810.14 ESL06969.1 - 2.6e-10 40.0 1.6 4.3e-09 36.1 0.0 3.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 ESL06969.1 - 9.4e-07 29.1 10.2 0.015 15.8 0.0 7.0 5 1 2 7 7 7 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 ESL06969.1 - 9e-06 25.9 3.6 0.046 14.1 0.0 5.4 3 2 2 5 5 5 1 Vacuolar 14 Fab1-binding region Arm PF00514.18 ESL06969.1 - 0.00023 20.8 3.8 10 6.0 0.0 5.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat DUF3677 PF12432.3 ESL06969.1 - 0.0038 17.6 3.0 0.047 14.1 0.0 4.0 4 0 0 4 4 4 1 Protein of unknown function (DUF3677) Xpo1 PF08389.7 ESL06969.1 - 0.019 14.8 6.5 0.4 10.5 0.0 4.9 4 1 0 4 4 4 0 Exportin 1-like protein DUF2454 PF10521.4 ESL06969.1 - 0.13 11.2 3.7 2.2 7.2 0.6 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2454) AAA_17 PF13207.1 ESL06971.1 - 2.7e-06 28.2 0.0 5.3e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL06971.1 - 9.6e-05 22.6 0.1 0.0002 21.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL06971.1 - 0.00023 21.2 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.5 ESL06971.1 - 0.0021 17.3 0.0 0.011 15.0 0.0 1.9 1 1 1 2 2 2 1 Chromatin associated protein KTI12 Thymidylate_kin PF02223.12 ESL06971.1 - 0.0099 15.2 0.2 0.14 11.5 0.1 2.3 2 0 0 2 2 2 1 Thymidylate kinase AAA PF00004.24 ESL06971.1 - 0.042 14.0 0.0 0.091 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ESL06971.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain Ribosomal_L14 PF00238.14 ESL06972.1 - 2.9e-36 123.9 0.0 3.4e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SNARE_assoc PF09335.6 ESL06974.1 - 1.6e-18 67.1 7.9 1.6e-18 67.1 5.5 3.1 3 1 0 3 3 3 1 SNARE associated Golgi protein DUF2206 PF09971.4 ESL06974.1 - 0.051 12.3 1.4 0.078 11.7 1.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Spo7 PF03907.8 ESL06974.1 - 0.09 12.3 0.2 0.17 11.4 0.2 1.5 1 0 0 1 1 1 0 Spo7-like protein OsmC PF02566.14 ESL06975.1 - 1.2e-08 35.0 0.1 1.5e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 OsmC-like protein DUF773 PF05600.7 ESL06976.1 - 1.3e-17 63.7 6.7 5.2e-11 42.0 3.1 3.0 1 1 1 2 2 2 2 Protein of unknown function (DUF773) Myosin_tail_1 PF01576.14 ESL06976.1 - 0.034 11.8 9.9 0.095 10.4 1.4 2.2 2 0 0 2 2 2 0 Myosin tail Lebercilin PF15619.1 ESL06976.1 - 0.035 13.5 0.1 0.035 13.5 0.1 2.5 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Lipoprotein_20 PF13942.1 ESL06976.1 - 0.23 11.0 4.9 4.1 6.8 0.2 2.5 2 0 0 2 2 2 0 YfhG lipoprotein LOH1CR12 PF10158.4 ESL06977.1 - 0.38 10.5 6.8 0.31 10.8 0.3 3.4 2 1 0 3 3 3 0 Tumour suppressor protein DUF1664 PF07889.7 ESL06977.1 - 3.3 7.5 13.4 0.21 11.3 0.2 3.7 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) TruB_N PF01509.13 ESL06977.1 - 4.3 7.4 7.3 1.4 9.0 0.1 2.9 2 1 1 3 3 3 0 TruB family pseudouridylate synthase (N terminal domain) Thioredoxin PF00085.15 ESL06978.1 - 1.6e-07 30.9 0.0 2.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.11 ESL06978.1 - 0.00031 19.5 0.2 0.00045 19.0 0.1 1.2 1 0 0 1 1 1 1 Phosducin DUF4417 PF14386.1 ESL06978.1 - 0.14 11.4 0.4 0.28 10.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4417) SNF2_N PF00176.18 ESL06979.1 - 6.1e-59 199.2 0.0 1.6e-58 197.9 0.0 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL06979.1 - 7.7e-11 41.7 0.0 1.8e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.1 ESL06979.1 - 8.6e-06 25.3 8.3 2e-05 24.1 5.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL06979.1 - 5.2e-05 23.1 10.0 0.00013 21.9 6.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 ESL06979.1 - 6.3e-05 22.5 0.0 0.00013 21.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.20 ESL06979.1 - 0.00013 21.4 9.1 0.00038 20.0 6.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL06979.1 - 0.00025 20.8 9.0 0.00075 19.2 6.2 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESL06979.1 - 0.0037 16.9 9.8 0.0099 15.5 6.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.10 ESL06979.1 - 0.0061 16.4 0.4 0.052 13.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4_4 PF15227.1 ESL06979.1 - 0.047 13.5 9.0 0.099 12.5 6.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESL06979.1 - 0.086 12.5 6.9 0.27 10.9 4.4 2.2 1 1 1 2 2 2 0 RING-type zinc-finger zf-4CXXC_R1 PF10497.4 ESL06979.1 - 0.11 12.7 10.9 0.032 14.3 5.0 2.0 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DUF607 PF04678.8 ESL06980.1 - 9.1e-43 146.2 0.0 1.3e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF607 Ribosomal_S2 PF00318.15 ESL06981.1 - 2.5e-43 147.7 0.6 5.4e-22 78.0 0.0 2.0 1 1 1 2 2 2 2 Ribosomal protein S2 Mito_carr PF00153.22 ESL06982.1 - 1.5e-28 98.3 0.3 1.1e-13 50.6 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein DoxX_2 PF13564.1 ESL06982.1 - 0.15 12.0 3.3 0.12 12.3 0.6 2.1 2 0 0 2 2 2 0 DoxX-like family XRN_N PF03159.13 ESL06983.1 - 1.1e-18 67.4 0.0 1.4e-11 44.2 0.0 2.4 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus PS_Dcarbxylase PF02666.10 ESL06984.1 - 1.6e-27 96.1 0.0 1.8e-27 95.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase HeH PF12949.2 ESL06985.1 - 0.045 13.2 0.0 7.2 6.2 0.0 2.6 2 0 0 2 2 2 0 HeH/LEM domain Metallophos PF00149.23 ESL06988.1 - 1e-21 77.2 0.0 3.3e-21 75.6 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase RIC1 PF07064.8 ESL06989.1 - 8.3e-54 182.7 0.0 1.4e-53 182.0 0.0 1.3 1 0 0 1 1 1 1 RIC1 eIF2A PF08662.6 ESL06989.1 - 0.14 11.8 0.0 17 5.0 0.0 3.1 2 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A UQ_con PF00179.21 ESL06990.1 - 5.7e-43 145.7 0.0 7.3e-43 145.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.6 ESL06990.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Methyltransf_31 PF13847.1 ESL06991.1 - 2.5e-14 53.1 0.0 4.5e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESL06991.1 - 2.9e-13 49.5 0.0 4.8e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 ESL06991.1 - 7.7e-11 42.5 0.1 1.7e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL06991.1 - 5e-10 39.4 0.1 1.5e-09 37.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESL06991.1 - 4.8e-09 35.8 0.2 7.7e-09 35.1 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 ESL06991.1 - 7.1e-09 36.0 0.1 3.5e-08 33.8 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL06991.1 - 8.3e-09 35.3 0.0 1.7e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL06991.1 - 3.1e-07 30.7 0.0 6.6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 ESL06991.1 - 4.2e-07 29.2 0.0 4.9e-07 29.0 0.0 1.0 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.7 ESL06991.1 - 6.8e-07 29.6 0.0 1.4e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESL06991.1 - 7e-07 28.6 0.2 1.2e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.9 ESL06991.1 - 7.6e-06 25.2 0.1 1.4e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 ESL06991.1 - 7.8e-06 24.7 0.1 1.2e-05 24.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) FtsJ PF01728.14 ESL06991.1 - 0.00095 19.1 0.4 0.0018 18.2 0.2 1.3 1 1 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.14 ESL06991.1 - 0.0022 17.5 0.1 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 ESL06991.1 - 0.0031 17.1 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESL06991.1 - 0.0036 16.4 0.0 0.0056 15.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Met_10 PF02475.11 ESL06991.1 - 0.0038 16.8 0.0 0.0061 16.1 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_4 PF02390.12 ESL06991.1 - 0.034 13.1 0.0 0.051 12.6 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_24 PF13578.1 ESL06991.1 - 0.053 14.3 0.1 0.22 12.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain ADH_zinc_N PF00107.21 ESL06991.1 - 0.069 12.6 0.3 0.13 11.8 0.2 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Cons_hypoth95 PF03602.10 ESL06991.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Kelch_6 PF13964.1 ESL06993.1 - 1.8e-28 97.4 21.4 3.2e-05 23.8 0.3 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_5 PF13854.1 ESL06993.1 - 2.1e-23 81.8 22.3 2.4e-07 30.5 0.1 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 ESL06993.1 - 2.6e-22 78.4 17.9 0.00069 19.7 0.2 7.4 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.1 ESL06993.1 - 4.9e-21 74.2 17.8 0.0005 19.7 0.0 6.6 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.20 ESL06993.1 - 4.2e-15 55.0 25.8 4.7e-05 22.8 0.0 7.5 6 2 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESL06993.1 - 5.2e-15 54.5 18.3 0.00064 19.3 0.0 6.5 6 1 0 6 6 6 4 Kelch motif FtsX PF02687.16 ESL06995.1 - 2.3e-25 88.7 35.7 9.2e-17 60.9 5.9 4.6 4 1 0 4 4 4 2 FtsX-like permease family Podoplanin PF05808.6 ESL06995.1 - 6.7 6.2 6.2 3.1 7.3 0.1 2.8 2 0 0 2 2 2 0 Podoplanin HOOK PF05622.7 ESL06996.1 - 2.1 6.0 49.4 0.33 8.6 18.3 2.4 2 0 0 2 2 2 0 HOOK protein GAF_2 PF13185.1 ESL06997.1 - 0.00026 21.4 0.0 0.059 13.8 0.0 2.5 2 0 0 2 2 2 2 GAF domain zf-RING_2 PF13639.1 ESL06998.1 - 0.16 11.8 2.4 28 4.6 0.1 3.1 3 0 0 3 3 3 0 Ring finger domain Arf PF00025.16 ESL06999.1 - 6.3e-55 185.0 0.0 7.3e-55 184.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ESL06999.1 - 6.5e-15 54.8 0.0 7.5e-15 54.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL06999.1 - 8.1e-10 39.2 0.0 1.8e-09 38.0 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein SRPRB PF09439.5 ESL06999.1 - 1.5e-09 37.3 0.0 1.7e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 ESL06999.1 - 2.3e-08 33.1 0.5 3.5e-05 22.6 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 ESL06999.1 - 3.3e-08 32.9 0.0 4.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL06999.1 - 7.1e-06 25.9 0.0 1.4e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL06999.1 - 0.00095 18.6 0.1 0.011 15.1 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 ESL06999.1 - 0.1 12.7 0.1 0.36 10.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain Acetyltransf_1 PF00583.19 ESL07000.1 - 1e-05 25.4 0.2 0.0013 18.6 0.1 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL07000.1 - 0.0028 17.7 0.1 0.044 13.9 0.1 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL07000.1 - 0.0092 15.8 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESL07000.1 - 0.065 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL07000.1 - 0.074 12.8 0.1 0.22 11.3 0.1 1.7 2 0 0 2 2 2 0 FR47-like protein GlcNAc PF11397.3 ESL07001.1 - 1.2e-121 406.0 0.0 1.3e-121 405.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) PolyA_pol_RNAbd PF12627.2 ESL07002.1 - 0.0051 16.3 0.6 0.0083 15.6 0.4 1.3 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A FUSC_2 PF13515.1 ESL07003.1 - 0.00042 20.2 8.1 0.00042 20.2 5.6 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 ESL07003.1 - 0.004 15.8 6.2 0.52 8.9 3.5 2.4 2 0 0 2 2 2 2 Aluminium activated malate transporter RRM_1 PF00076.17 ESL07005.1 - 0.00027 20.5 0.0 0.0018 17.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07005.1 - 0.00055 19.7 0.0 0.0024 17.6 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL07005.1 - 0.0032 17.4 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESL07005.1 - 0.015 15.0 0.0 4.2 7.1 0.0 2.1 2 0 0 2 2 2 0 Limkain b1 DUF1866 PF08952.6 ESL07005.1 - 0.017 14.6 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) 2-Hacid_dh_C PF02826.14 ESL07007.1 - 9.2e-46 155.2 0.0 1.1e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESL07007.1 - 2.7e-06 26.8 0.0 3.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_10 PF13460.1 ESL07007.1 - 9.5e-06 25.7 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 ESL07007.1 - 0.00011 22.1 0.1 0.00025 21.0 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESL07007.1 - 0.0002 21.2 0.0 0.00026 20.8 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESL07007.1 - 0.00021 21.6 0.0 0.00039 20.8 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 ESL07007.1 - 0.0011 18.7 0.1 0.003 17.4 0.1 1.7 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.14 ESL07007.1 - 0.003 16.2 0.0 0.0036 15.9 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.16 ESL07007.1 - 0.0059 16.2 0.1 0.013 15.1 0.0 1.4 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.1 ESL07007.1 - 0.01 16.0 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Gp_dh_N PF00044.19 ESL07007.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESL07007.1 - 0.034 13.8 0.4 0.056 13.0 0.3 1.4 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 ESL07007.1 - 0.034 13.1 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase XdhC_C PF13478.1 ESL07007.1 - 0.059 13.6 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain WD40 PF00400.27 ESL07008.1 - 0.0083 15.9 0.1 0.068 13.0 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF4638 PF15472.1 ESL07008.1 - 0.019 14.5 3.0 0.025 14.1 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Tol_Tol_Ttg2 PF05494.7 ESL07008.1 - 0.078 12.5 1.6 0.13 11.8 1.1 1.3 1 0 0 1 1 1 0 Toluene tolerance, Ttg2 PQQ_3 PF13570.1 ESL07008.1 - 0.13 12.6 0.3 1 9.7 0.0 2.4 2 0 0 2 2 2 0 PQQ-like domain DDRGK PF09756.4 ESL07008.1 - 0.26 10.6 10.0 0.38 10.1 7.0 1.2 1 0 0 1 1 1 0 DDRGK domain RNase_H2-Ydr279 PF09468.5 ESL07008.1 - 4.8 6.2 5.9 7 5.7 4.1 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Lectin_C PF00059.16 ESL07010.1 - 2.6e-07 31.2 0.0 0.11 13.1 0.0 3.8 3 1 0 3 3 3 3 Lectin C-type domain SR-25 PF10500.4 ESL07012.1 - 2.3 7.6 12.5 0.93 8.9 6.8 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein tRNA-synt_2c PF01411.14 ESL07014.1 - 1e-07 30.6 0.0 2.2e-07 29.5 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 ESL07014.1 - 4.5e-06 26.4 2.0 6.9e-06 25.8 0.6 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain GHMP_kinases_N PF00288.21 ESL07015.1 - 7.8e-07 29.0 3.0 1.9e-06 27.8 2.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain Tubulin PF00091.20 ESL07017.1 - 1.7e-52 178.4 0.0 2.3e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.1 ESL07017.1 - 0.0056 15.6 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin like DUF4499 PF14934.1 ESL07018.1 - 0.00014 21.6 2.0 0.00015 21.6 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4499) DZR PF12773.2 ESL07019.1 - 3.7e-09 36.2 147.9 0.013 15.2 12.0 12.3 7 2 6 14 14 14 12 Double zinc ribbon MAM33 PF02330.11 ESL07020.1 - 1.9e-18 66.9 0.3 1.1e-17 64.4 0.1 1.9 1 1 1 2 2 2 1 Mitochondrial glycoprotein MbtH PF03621.8 ESL07020.1 - 0.0064 15.8 0.2 0.12 11.7 0.0 2.3 2 0 0 2 2 2 1 MbtH-like protein FBPase PF00316.15 ESL07021.1 - 2e-110 368.6 0.0 2.3e-110 368.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase DUF3733 PF12534.3 ESL07021.1 - 0.11 11.7 0.1 0.38 10.0 0.1 1.8 2 0 0 2 2 2 0 Leucine-rich repeat containing protein 8 Flg_bb_rod PF00460.15 ESL07021.1 - 4.3 7.1 5.5 0.86 9.3 1.0 1.9 2 0 0 2 2 2 0 Flagella basal body rod protein HEAT_2 PF13646.1 ESL07022.1 - 1.6e-12 47.5 1.4 0.0011 19.1 0.0 6.2 4 1 3 7 7 7 4 HEAT repeats HEAT PF02985.17 ESL07022.1 - 1.8e-10 39.9 21.8 0.011 15.7 0.0 8.9 8 1 1 9 9 9 3 HEAT repeat Orthoreo_P10 PF07204.6 ESL07022.1 - 0.0048 16.5 1.5 0.018 14.7 0.0 2.6 3 0 0 3 3 3 1 Orthoreovirus membrane fusion protein p10 CLASP_N PF12348.3 ESL07022.1 - 0.26 10.6 1.5 25 4.1 0.0 3.8 5 0 0 5 5 5 0 CLASP N terminal Cnd1 PF12717.2 ESL07022.1 - 0.34 10.7 2.1 5.8 6.7 0.1 3.3 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Coq4 PF05019.8 ESL07023.1 - 4.3e-71 238.3 0.0 5.2e-71 238.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF1289 PF06945.8 ESL07023.1 - 0.038 13.4 0.1 0.088 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) DUF4331 PF14224.1 ESL07023.1 - 0.053 12.6 0.0 0.063 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4331) SNAP PF14938.1 ESL07024.1 - 5.1e-11 42.2 17.4 0.0024 17.0 5.7 3.3 2 1 1 3 3 3 3 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 ESL07024.1 - 0.0012 18.4 4.1 0.41 10.5 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL07024.1 - 0.007 16.2 1.8 0.36 10.7 0.2 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07024.1 - 0.031 14.8 3.2 1.1 10.0 0.0 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat NSF PF02071.15 ESL07024.1 - 0.4 11.4 11.2 8.9 7.3 1.4 4.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat CRAL_TRIO PF00650.15 ESL07025.1 - 1.5e-21 76.5 0.2 2.6e-21 75.7 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESL07025.1 - 2.3e-09 37.2 0.4 5e-09 36.1 0.3 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain zf-piccolo PF05715.8 ESL07025.1 - 2.2 8.3 4.8 0.78 9.7 0.2 2.5 3 0 0 3 3 3 0 Piccolo Zn-finger Carn_acyltransf PF00755.15 ESL07026.1 - 4.7e-112 375.0 0.0 6.9e-112 374.4 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF3639 PF12341.3 ESL07027.1 - 4.6e-05 23.3 1.5 0.00015 21.6 1.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3639) WD40 PF00400.27 ESL07027.1 - 0.00042 20.0 1.2 3.5 7.6 0.0 4.8 3 1 0 3 3 3 2 WD domain, G-beta repeat Nop52 PF05997.7 ESL07028.1 - 2.5e-34 118.6 1.7 1.7e-28 99.5 0.8 3.1 3 0 0 3 3 3 3 Nucleolar protein,Nop52 BCD PF15461.1 ESL07028.1 - 0.058 12.7 0.1 0.088 12.2 0.1 1.2 1 0 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase Clp1 PF06807.9 ESL07029.1 - 6e-07 29.4 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA_22 PF13401.1 ESL07029.1 - 0.0058 16.7 0.0 0.02 15.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL07029.1 - 0.01 15.5 1.2 0.05 13.3 0.1 2.5 2 0 0 2 2 2 0 Part of AAA domain T2SE PF00437.15 ESL07029.1 - 0.07 12.0 0.1 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.7 ESL07029.1 - 0.13 11.9 0.0 5.6 6.5 0.0 2.3 2 0 0 2 2 2 0 NACHT domain MatE PF01554.13 ESL07030.1 - 8.8e-41 139.2 26.3 3.7e-21 75.4 5.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 ESL07030.1 - 0.00059 19.6 8.3 0.00059 19.6 5.8 4.4 2 1 2 4 4 4 1 Polysaccharide biosynthesis C-terminal domain Alkyl_sulf_C PF14864.1 ESL07031.1 - 0.08 12.9 6.9 0.13 12.2 0.0 3.0 4 0 0 4 4 4 0 Alkyl sulfatase C-terminal Cpn60_TCP1 PF00118.19 ESL07034.1 - 2.3e-103 346.4 2.9 2.6e-103 346.2 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DNA_RNApol_7kD PF03604.8 ESL07035.1 - 2.1e-05 23.8 0.9 3.3e-05 23.2 0.6 1.4 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf-UBR PF02207.15 ESL07035.1 - 0.014 15.0 1.1 0.017 14.8 0.8 1.1 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) FYVE_2 PF02318.11 ESL07035.1 - 0.053 13.4 0.4 0.061 13.2 0.3 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger NinF PF05810.7 ESL07035.1 - 0.16 11.8 0.7 0.23 11.2 0.5 1.3 1 0 0 1 1 1 0 NinF protein TFIIS_C PF01096.13 ESL07035.1 - 0.71 9.5 5.3 0.98 9.1 0.2 2.7 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) PAP_assoc PF03828.14 ESL07036.1 - 2.4e-10 40.1 0.0 7.1e-10 38.6 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESL07036.1 - 7.5e-07 29.3 0.0 1.6e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cullin_binding PF03556.10 ESL07037.1 - 2e-27 95.6 0.5 2.7e-27 95.2 0.3 1.2 1 0 0 1 1 1 1 Cullin binding DNA_primase_lrg PF04104.9 ESL07037.1 - 0.074 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit DUF972 PF06156.8 ESL07038.1 - 1.5 9.2 16.1 2.4 8.5 0.2 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF972) IFT57 PF10498.4 ESL07038.1 - 1.6 7.3 6.9 9.3 4.8 1.7 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 XPC-binding PF09280.6 ESL07039.1 - 7.7e-05 22.0 0.0 0.00022 20.6 0.0 1.8 1 0 0 1 1 1 1 XPC-binding domain TPR_11 PF13414.1 ESL07041.1 - 1.2e-17 63.3 15.5 1.6e-06 27.6 1.3 6.1 3 2 3 6 6 6 5 TPR repeat TPR_16 PF13432.1 ESL07041.1 - 8.3e-16 58.1 0.4 5.9e-06 26.7 0.0 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07041.1 - 1.2e-14 54.3 11.2 0.00011 22.4 0.0 6.4 6 2 2 8 8 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESL07041.1 - 9.6e-14 50.1 15.2 0.00089 18.9 0.0 8.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL07041.1 - 2.6e-12 46.5 7.9 0.0015 18.3 0.1 6.6 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07041.1 - 3.9e-09 36.3 3.0 0.0016 18.8 0.0 6.9 4 3 4 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07041.1 - 7.7e-08 31.5 2.8 1.7 8.6 0.0 7.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL07041.1 - 2.5e-07 30.6 8.5 0.016 15.6 0.0 7.9 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07041.1 - 2.8e-07 29.8 16.2 0.032 13.8 0.0 8.0 8 0 0 8 8 8 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL07041.1 - 4.3e-07 29.9 14.6 0.0003 20.8 2.9 4.7 2 2 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESL07041.1 - 8.5e-05 22.3 1.5 0.0045 16.8 0.7 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL07041.1 - 0.00059 19.6 5.4 3.8 7.5 0.0 5.7 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL07041.1 - 0.0028 17.7 0.6 5.4 7.4 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL07041.1 - 0.0041 16.9 15.3 0.28 11.1 0.0 5.1 4 1 2 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.12 ESL07041.1 - 0.06 13.6 0.5 0.3 11.3 0.1 2.4 3 0 0 3 3 2 0 Bacterial transcriptional activator domain TPR_8 PF13181.1 ESL07041.1 - 0.1 12.4 12.1 1.3 8.9 0.0 6.7 9 0 0 9 9 9 0 Tetratricopeptide repeat PPR_2 PF13041.1 ESL07041.1 - 0.12 12.3 0.4 6.9 6.7 0.0 3.9 4 0 0 4 4 4 0 PPR repeat family Oxidored-like PF09791.4 ESL07041.1 - 0.17 11.3 0.4 0.55 9.7 0.1 2.0 2 0 0 2 2 2 0 Oxidoreductase-like protein, N-terminal RPN7 PF10602.4 ESL07041.1 - 0.25 10.7 3.3 4.3 6.6 0.1 3.7 2 1 1 3 3 3 0 26S proteasome subunit RPN7 PPR PF01535.15 ESL07041.1 - 0.91 9.6 8.5 5.9 7.0 0.1 4.9 7 0 0 7 7 4 0 PPR repeat DUF3689 PF12463.3 ESL07043.1 - 0.0033 16.2 0.0 0.95 8.1 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF3689) SLA_LP_auto_ag PF05889.8 ESL07044.1 - 4.5e-94 315.1 0.0 1.1e-54 185.4 0.0 2.9 2 2 0 2 2 2 2 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Beta_elim_lyase PF01212.16 ESL07044.1 - 0.007 15.5 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Hus1 PF04005.7 ESL07046.1 - 1.3e-67 227.8 0.0 1.4e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein DUF3549 PF12069.3 ESL07048.1 - 0.011 14.5 0.6 0.09 11.5 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3549) Chlorophyllase PF07224.6 ESL07049.1 - 0.0031 16.3 0.1 0.0051 15.6 0.1 1.3 1 0 0 1 1 1 1 Chlorophyllase CENP-F_leu_zip PF10473.4 ESL07049.1 - 0.0044 16.8 8.8 0.0044 16.8 6.1 5.1 3 3 2 5 5 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin-6_N PF09177.6 ESL07049.1 - 0.038 14.3 0.9 0.038 14.3 0.6 5.8 3 2 2 5 5 5 0 Syntaxin 6, N-terminal Reo_sigmaC PF04582.7 ESL07049.1 - 0.27 10.3 18.2 0.52 9.4 0.1 3.6 2 1 2 4 4 4 0 Reovirus sigma C capsid protein Cast PF10174.4 ESL07049.1 - 1.4 6.8 56.4 2.7 5.9 32.4 2.3 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone DUF1042 PF06294.6 ESL07052.1 - 8.3e-32 109.9 0.0 1.1e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 ESL07052.1 - 1.1e-26 92.3 0.0 1.6e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.26 ESL07052.1 - 1.2e-05 25.3 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Myosin_HC-like PF07058.6 ESL07052.1 - 0.017 14.2 0.0 0.021 13.9 0.0 1.1 1 0 0 1 1 1 0 Myosin II heavy chain-like CSTF2_hinge PF14327.1 ESL07053.1 - 0.022 14.8 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 Ribosomal_L13 PF00572.13 ESL07054.1 - 9.3e-29 100.0 0.0 1.2e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Isy1 PF06246.7 ESL07055.1 - 2.3e-13 50.1 6.9 1.2e-12 47.8 4.8 1.8 1 1 0 1 1 1 1 Isy1-like splicing family DNA_alkylation PF08713.6 ESL07055.1 - 0.019 14.5 0.1 0.036 13.5 0.0 1.5 2 0 0 2 2 2 0 DNA alkylation repair enzyme CAP_GLY PF01302.20 ESL07056.1 - 9.9e-17 60.4 0.8 1.7e-16 59.6 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain Mito_carr PF00153.22 ESL07057.1 - 5.9e-58 192.5 6.9 8.2e-22 76.7 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein IBN_N PF03810.14 ESL07058.1 - 0.004 17.0 0.0 0.0081 16.0 0.0 1.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF106 PF01956.11 ESL07059.1 - 1.8e-45 154.4 2.4 2.4e-45 154.1 1.7 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 Glycos_transf_4 PF00953.16 ESL07060.1 - 8.6e-38 129.6 5.8 8.6e-38 129.6 4.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 4 FKBP_C PF00254.23 ESL07061.1 - 5.4e-32 109.6 0.0 1.5e-30 105.0 0.0 2.3 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 ESL07061.1 - 2.6e-16 59.0 9.9 2.8e-09 36.4 0.7 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESL07061.1 - 3.8e-11 42.0 8.0 0.008 16.0 1.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07061.1 - 8.7e-06 25.1 5.9 0.013 15.1 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07061.1 - 4.9e-05 23.8 8.8 0.054 14.1 0.3 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL07061.1 - 0.00033 20.4 4.7 0.0087 15.9 0.4 2.9 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.1 ESL07061.1 - 0.00041 20.2 3.3 0.028 14.3 0.6 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07061.1 - 0.0071 16.8 6.0 10 7.0 0.4 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL07061.1 - 0.014 15.5 1.9 0.041 14.0 1.3 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESL07061.1 - 0.094 12.5 1.8 0.79 9.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESL07061.1 - 0.097 12.9 0.2 18 5.8 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07061.1 - 0.26 11.6 6.1 0.64 10.3 1.9 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07061.1 - 0.99 9.3 3.4 87 3.2 0.0 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL07063.1 - 2.5e-24 85.8 0.1 1.8e-12 47.0 0.0 4.1 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07063.1 - 0.00039 19.5 0.2 0.5 9.3 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase DUF2404 PF10296.4 ESL07064.1 - 2.4e-21 75.6 0.0 4.5e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) LrgA PF03788.9 ESL07065.1 - 0.036 13.7 0.1 5.4 6.7 0.0 2.2 2 0 0 2 2 2 0 LrgA family CYTH PF01928.16 ESL07066.1 - 2.1e-11 43.8 0.0 1.5e-07 31.2 0.0 2.9 3 1 0 3 3 3 2 CYTH domain PX PF00787.19 ESL07067.1 - 1.1e-11 44.5 0.1 3.4e-11 42.9 0.0 1.9 1 0 0 1 1 1 1 PX domain SAB PF04382.8 ESL07067.1 - 0.035 13.8 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 SAB domain Cnd3 PF12719.2 ESL07071.1 - 9.2e-23 80.6 0.1 9.2e-23 80.6 0.1 2.5 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 ESL07071.1 - 7.1e-07 29.4 2.7 0.0025 18.0 0.2 5.4 5 2 2 7 7 7 3 HEAT repeats HEAT PF02985.17 ESL07071.1 - 0.003 17.4 8.4 4.2 7.7 0.2 5.7 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 ESL07071.1 - 0.0081 16.6 4.3 0.5 10.9 0.1 3.6 3 0 0 3 3 3 2 HEAT-like repeat MMS19_C PF12460.3 ESL07071.1 - 0.51 8.9 3.9 11 4.6 0.1 3.2 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal GTP1_OBG PF01018.17 ESL07072.1 - 0.022 14.4 0.1 0.055 13.1 0.1 1.7 1 0 0 1 1 1 0 GTP1/OBG PilJ PF13675.1 ESL07073.1 - 0.12 12.7 4.3 3.8 7.8 0.2 2.8 3 1 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Spectrin PF00435.16 ESL07073.1 - 1.9 8.8 12.4 2.9 8.2 0.4 4.1 3 1 1 4 4 4 0 Spectrin repeat RAB3GAP2_N PF14655.1 ESL07075.1 - 5.1e-13 48.8 0.0 1.1e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus tRNA-synt_1b PF00579.20 ESL07076.1 - 2.2e-19 69.6 0.0 1.8e-18 66.6 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) CorA PF01544.13 ESL07077.1 - 9e-26 90.5 0.6 6.5e-23 81.1 0.4 2.2 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SHOCT PF09851.4 ESL07077.1 - 3.4e-06 26.3 0.1 6.5e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Short C-terminal domain Macoilin PF09726.4 ESL07077.1 - 0.37 9.0 9.7 0.59 8.3 6.7 1.2 1 0 0 1 1 1 0 Transmembrane protein DNA_pol_viral_N PF00242.12 ESL07077.1 - 1.9 7.4 13.3 3.5 6.5 9.2 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain KAR9 PF08580.5 ESL07078.1 - 0.011 14.1 0.1 0.011 14.1 0.1 1.8 2 1 0 2 2 2 0 Yeast cortical protein KAR9 ADIP PF11559.3 ESL07078.1 - 1.1 9.1 7.4 7.7 6.4 3.8 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Phage_Mu_Gam PF07352.7 ESL07078.1 - 2.3 7.7 5.8 11 5.5 3.0 2.1 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein ALS_ss_C PF10369.4 ESL07079.1 - 0.042 13.5 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Small subunit of acetolactate synthase DUF553 PF04473.7 ESL07079.1 - 0.084 12.1 0.5 0.12 11.6 0.3 1.2 1 0 0 1 1 1 0 Transglutaminase-like domain Kelch_5 PF13854.1 ESL07080.1 - 1.9e-25 88.3 0.3 1.1e-07 31.5 0.0 5.9 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.1 ESL07080.1 - 1.7e-23 82.1 19.1 5.4e-07 29.2 0.4 7.2 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL07080.1 - 4.5e-21 74.4 17.7 0.00013 22.0 0.0 8.0 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESL07080.1 - 2.7e-20 71.6 6.3 3.6e-06 26.4 0.0 6.4 7 0 0 7 7 7 3 Kelch motif Kelch_6 PF13964.1 ESL07080.1 - 4.5e-19 67.7 5.3 2.8e-05 24.0 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESL07080.1 - 6.8e-15 54.1 14.4 0.0005 19.7 0.1 6.3 6 1 0 6 6 6 4 Kelch motif BTB PF00651.26 ESL07080.1 - 7.4e-08 32.3 0.0 0.00013 21.8 0.0 4.2 3 2 0 3 3 3 1 BTB/POZ domain GRAM PF02893.15 ESL07083.1 - 4.3e-10 38.9 0.0 1.4e-09 37.3 0.0 1.9 2 0 0 2 2 2 1 GRAM domain Kinesin PF00225.18 ESL07084.1 - 3.4e-101 338.3 0.3 4.6e-101 337.8 0.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Ras PF00071.17 ESL07084.1 - 5.6e-05 22.5 0.0 0.00022 20.6 0.0 2.1 2 0 0 2 2 2 1 Ras family FHA PF00498.21 ESL07084.1 - 0.00039 20.4 0.0 0.0012 18.9 0.0 1.9 2 0 0 2 2 2 1 FHA domain Miro PF08477.8 ESL07084.1 - 0.019 15.4 0.0 0.11 13.0 0.0 2.3 3 0 0 3 3 3 0 Miro-like protein AAA_22 PF13401.1 ESL07084.1 - 0.081 13.0 0.1 19 5.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESL07084.1 - 0.16 11.5 0.7 8.5 5.9 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Mito_fiss_reg PF05308.6 ESL07085.1 - 2.3 7.5 6.2 4.2 6.6 4.3 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Slu7 PF11708.3 ESL07087.1 - 0.064 12.9 9.3 0.12 12.1 3.3 2.7 1 1 1 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor AAA PF00004.24 ESL07088.1 - 4.3e-32 111.0 0.0 6.8e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL07088.1 - 5.2e-07 29.8 0.1 4.2e-06 26.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESL07088.1 - 2.8e-06 27.6 0.0 5.6e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL07088.1 - 4.2e-06 26.8 0.1 1.3e-05 25.2 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 ESL07088.1 - 1.2e-05 24.7 0.6 0.002 17.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 ESL07088.1 - 1.4e-05 25.8 0.0 3.1e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESL07088.1 - 6.5e-05 22.6 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESL07088.1 - 0.00014 21.6 0.0 0.12 12.0 0.0 2.2 1 1 1 2 2 2 2 Archaeal ATPase AAA_19 PF13245.1 ESL07088.1 - 0.0003 20.4 0.0 0.0012 18.5 0.0 2.0 2 0 0 2 2 1 1 Part of AAA domain AAA_33 PF13671.1 ESL07088.1 - 0.0004 20.2 0.1 0.0021 17.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.1 ESL07088.1 - 0.00062 19.8 0.0 0.0023 18.0 0.0 1.9 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.9 ESL07088.1 - 0.00063 19.4 0.1 0.0019 17.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 ESL07088.1 - 0.00095 18.6 0.0 0.006 16.0 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL07088.1 - 0.0013 18.8 0.0 0.0024 18.0 0.0 1.6 1 1 0 1 1 1 1 RNA helicase DUF815 PF05673.8 ESL07088.1 - 0.0033 16.3 0.0 0.02 13.8 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESL07088.1 - 0.0041 16.2 0.0 0.0074 15.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus UPF0079 PF02367.12 ESL07088.1 - 0.0061 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_14 PF13173.1 ESL07088.1 - 0.0088 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESL07088.1 - 0.014 15.3 0.0 0.037 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 ESL07088.1 - 0.029 13.0 0.0 0.044 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NACHT PF05729.7 ESL07088.1 - 0.03 13.9 0.1 0.075 12.6 0.0 1.8 2 1 0 2 2 1 0 NACHT domain Mg_chelatase PF01078.16 ESL07088.1 - 0.032 13.3 0.0 0.068 12.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.9 ESL07088.1 - 0.032 13.2 0.0 0.11 11.5 0.0 1.7 1 1 0 1 1 1 0 KAP family P-loop domain TIP49 PF06068.8 ESL07088.1 - 0.035 12.8 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_21 PF13304.1 ESL07088.1 - 0.04 13.8 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad51 PF08423.6 ESL07088.1 - 0.042 12.7 0.3 0.18 10.6 0.1 1.9 1 1 1 2 2 2 0 Rad51 ABC_tran PF00005.22 ESL07088.1 - 0.045 14.0 0.0 0.084 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 ESL07088.1 - 0.067 12.7 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESL07088.1 - 0.071 12.6 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 ESL07088.1 - 0.12 12.0 0.0 0.27 10.8 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 ESL07088.1 - 0.15 11.2 0.0 0.36 9.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Parvo_NS1 PF01057.12 ESL07088.1 - 0.18 10.6 0.0 0.42 9.4 0.0 1.5 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 dCMP_cyt_deam_1 PF00383.17 ESL07089.1 - 8.8e-06 25.3 0.3 2e-05 24.1 0.2 1.6 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region NDUFA12 PF05071.11 ESL07090.1 - 5.2e-06 26.8 1.3 1.1e-05 25.7 0.4 1.9 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 IQ PF00612.22 ESL07092.1 - 0.91 9.3 9.3 4 7.3 0.8 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif TB2_DP1_HVA22 PF03134.14 ESL07094.1 - 1.3e-05 24.8 0.3 2.4e-05 23.9 0.2 1.6 1 1 0 1 1 1 1 TB2/DP1, HVA22 family Abhydrolase_6 PF12697.2 ESL07095.1 - 3.1e-12 46.8 0.0 4.8e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL07095.1 - 3e-06 27.0 0.0 8.9e-06 25.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL07095.1 - 0.00017 21.2 0.1 0.0079 15.7 0.0 2.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pkinase PF00069.20 ESL07097.1 - 1.9e-62 210.7 0.0 1.1e-60 204.9 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07097.1 - 3.5e-28 98.3 0.2 2e-21 76.2 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESL07097.1 - 0.00068 18.7 0.5 0.0031 16.6 0.4 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family UQ_con PF00179.21 ESL07098.1 - 1.1e-35 122.0 0.0 1.5e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RRM_1 PF00076.17 ESL07099.1 - 1.2e-15 56.9 0.1 2.8e-15 55.7 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL07099.1 - 1.1e-11 44.4 0.0 2.3e-11 43.5 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07099.1 - 1.5e-05 24.7 0.1 2.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med15 PF09606.5 ESL07099.1 - 0.089 10.9 13.1 0.11 10.7 9.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2076 PF09849.4 ESL07099.1 - 0.13 12.2 10.7 0.17 11.9 7.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CMV_1a PF12467.3 ESL07099.1 - 0.67 10.3 4.4 0.53 10.6 2.1 1.6 1 1 1 2 2 2 0 Cucumber mosaic virus 1a protein family Siah-Interact_N PF09032.6 ESL07099.1 - 0.85 9.7 9.6 0.14 12.2 2.8 2.1 2 0 0 2 2 2 0 Siah interacting protein, N terminal PAT1 PF09770.4 ESL07099.1 - 6.8 4.7 14.0 7.7 4.6 9.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-5_eIF-2B PF01873.12 ESL07100.1 - 1.4e-23 82.9 3.1 3e-23 81.8 0.6 2.1 2 0 0 2 2 2 1 Domain found in IF2B/IF5 WW PF00397.21 ESL07104.1 - 8e-15 54.3 7.8 5.2e-07 29.4 0.2 2.4 2 0 0 2 2 2 2 WW domain TFIIA PF03153.8 ESL07104.1 - 0.74 9.6 5.9 0.8 9.5 4.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TP53IP5 PF15331.1 ESL07104.1 - 1.9 8.3 6.3 0.42 10.4 1.3 1.8 1 1 1 2 2 2 0 Cellular tumour antigen p53-inducible 5 Sec1 PF00995.18 ESL07106.1 - 2.2e-20 72.8 0.0 2.5e-20 72.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Leu_Phe_trans PF03588.9 ESL07108.1 - 1.8e-06 27.1 0.0 2.9e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase NuA4 PF09340.5 ESL07109.1 - 0.24 11.0 3.4 0.83 9.3 0.3 2.5 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 AAA_12 PF13087.1 ESL07110.1 - 9.3e-35 119.8 0.0 1.5e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESL07110.1 - 3.3e-21 75.9 0.0 1.2e-20 74.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 ESL07110.1 - 8.5e-09 35.2 0.1 0.0018 17.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESL07110.1 - 1.2e-05 24.9 0.0 9.4e-05 22.0 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain Viral_helicase1 PF01443.13 ESL07110.1 - 0.0028 17.2 0.4 1.1 8.7 0.1 3.1 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 ESL07110.1 - 0.0083 16.2 0.3 0.54 10.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 ESL07110.1 - 0.021 15.6 0.8 0.19 12.5 0.1 2.8 2 1 0 2 2 2 0 AAA domain PhoH PF02562.11 ESL07110.1 - 0.022 14.0 0.0 0.2 10.8 0.0 2.5 3 0 0 3 3 3 0 PhoH-like protein AAA_16 PF13191.1 ESL07110.1 - 0.073 13.0 1.1 1.1 9.2 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain zf-CCHC_4 PF14392.1 ESL07110.1 - 0.12 12.0 1.4 0.27 10.9 1.0 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF2075 PF09848.4 ESL07110.1 - 0.15 10.9 0.0 0.33 9.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Adeno_E3_CR2 PF02439.10 ESL07111.1 - 0.55 9.8 9.4 1.1 8.8 6.5 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 S-methyl_trans PF02574.11 ESL07112.1 - 1e-31 110.3 0.0 1.2e-22 80.6 0.0 3.9 2 1 0 2 2 2 2 Homocysteine S-methyltransferase DUF1331 PF07048.6 ESL07112.1 - 0.039 13.4 0.1 0.08 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Pkinase PF00069.20 ESL07114.1 - 1.5e-68 230.7 0.0 1.8e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07114.1 - 5.4e-35 120.7 0.0 7.4e-34 116.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase DUF2656 PF10847.3 ESL07114.1 - 0.0089 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2656) Arf PF00025.16 ESL07115.1 - 1.4e-44 151.3 0.0 1.6e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESL07115.1 - 1.8e-09 37.0 0.0 2.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL07115.1 - 1.3e-08 34.8 0.0 1.8e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 ESL07115.1 - 1.1e-06 28.1 0.0 1.4e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 ESL07115.1 - 3.3e-06 26.0 1.1 0.00012 20.8 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 ESL07115.1 - 1.2e-05 24.6 0.0 1.3e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESL07115.1 - 2.6e-05 24.6 0.0 4.7e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 ESL07115.1 - 0.00011 21.6 0.0 0.0048 16.3 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESL07115.1 - 0.029 13.6 0.0 0.091 12.0 0.0 1.8 2 1 0 2 2 2 0 Ferrous iron transport protein B ATP-synt_Eps PF04627.8 ESL07116.1 - 2.7e-08 33.2 0.4 3.4e-08 32.9 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Gp_dh_C PF02800.15 ESL07117.1 - 1e-32 112.7 0.0 1.2e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain EF_TS PF00889.14 ESL07118.1 - 2.7e-16 59.5 0.2 4e-16 59.0 0.2 1.3 1 0 0 1 1 1 1 Elongation factor TS UBA PF00627.26 ESL07118.1 - 0.0084 15.9 0.1 0.023 14.5 0.0 1.8 2 0 0 2 2 2 1 UBA/TS-N domain PMEI PF04043.10 ESL07118.1 - 0.23 11.3 2.3 0.58 10.0 0.2 2.1 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Mpp10 PF04006.7 ESL07119.1 - 1.1e-56 192.4 42.6 9.6e-55 186.0 29.6 2.9 1 1 0 1 1 1 1 Mpp10 protein AAA PF00004.24 ESL07120.1 - 2.3e-38 131.4 0.0 4.3e-38 130.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL07120.1 - 6.5e-07 29.1 0.2 1.2e-05 25.0 0.1 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESL07120.1 - 1.4e-06 28.5 0.1 7.2e-05 22.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain Vps4_C PF09336.5 ESL07120.1 - 4.2e-06 26.5 0.0 9.2e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.7 ESL07120.1 - 1.2e-05 24.5 0.0 2.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESL07120.1 - 9.6e-05 22.0 0.2 0.0012 18.5 0.0 2.8 3 1 0 3 3 3 1 Part of AAA domain AAA_17 PF13207.1 ESL07120.1 - 0.00017 22.4 0.0 0.00032 21.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL07120.1 - 0.00024 19.9 0.0 0.00056 18.7 0.0 1.5 1 1 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESL07120.1 - 0.00069 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 ESL07120.1 - 0.0011 18.9 0.0 0.0064 16.4 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 ESL07120.1 - 0.0019 18.1 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 ESL07120.1 - 0.0025 16.9 0.0 0.0058 15.8 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 ESL07120.1 - 0.0025 17.2 0.2 0.13 11.6 0.0 2.3 1 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESL07120.1 - 0.0034 16.5 0.0 0.0077 15.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 ESL07120.1 - 0.0049 16.7 0.0 0.016 15.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.1 ESL07120.1 - 0.012 15.5 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESL07120.1 - 0.033 13.1 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.1 ESL07120.1 - 0.033 14.4 0.0 0.082 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESL07120.1 - 0.039 13.4 0.0 0.54 9.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 ESL07120.1 - 0.05 12.4 0.0 0.084 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.17 ESL07120.1 - 0.058 13.5 0.0 0.15 12.2 0.0 1.7 2 0 0 2 2 1 0 RNA helicase AAA_28 PF13521.1 ESL07120.1 - 0.061 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESL07120.1 - 0.077 13.2 0.0 2.7 8.3 0.0 2.4 1 1 1 2 2 2 0 ABC transporter NACHT PF05729.7 ESL07120.1 - 0.079 12.6 0.0 0.42 10.2 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.1 ESL07120.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cullin PF00888.17 ESL07121.1 - 3.7e-78 263.5 0.0 5.3e-78 263.0 0.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESL07121.1 - 3.9e-16 58.6 0.4 6.4e-15 54.7 0.0 3.0 3 0 0 3 3 3 1 Cullin protein neddylation domain HTH_20 PF12840.2 ESL07121.1 - 0.00025 20.7 0.0 0.022 14.5 0.0 2.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_9 PF08221.6 ESL07121.1 - 0.021 14.7 0.7 0.12 12.2 0.2 2.5 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain LexA_DNA_bind PF01726.11 ESL07121.1 - 0.057 12.9 0.0 0.21 11.1 0.0 2.0 2 0 0 2 2 2 0 LexA DNA binding domain TrmB PF01978.14 ESL07121.1 - 0.057 13.1 0.1 2.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HbrB PF08539.6 ESL07121.1 - 0.089 12.6 1.6 0.14 11.9 0.3 2.0 2 0 0 2 2 2 0 HbrB-like SET PF00856.23 ESL07123.1 - 1.1e-13 51.7 0.0 1.4e-12 48.1 0.0 2.7 2 1 0 2 2 2 1 SET domain zf-RING_4 PF14570.1 ESL07123.1 - 0.058 12.9 2.8 0.18 11.3 1.9 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Exc PF07825.6 ESL07124.1 - 0.011 15.4 0.2 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 Excisionase-like protein Sec1 PF00995.18 ESL07127.1 - 2.7e-92 310.2 0.4 3.1e-92 310.0 0.3 1.0 1 0 0 1 1 1 1 Sec1 family SET PF00856.23 ESL07128.1 - 0.00012 22.4 0.0 0.00025 21.4 0.0 1.7 1 1 0 1 1 1 1 SET domain Tmemb_cc2 PF10267.4 ESL07131.1 - 4.8e-05 22.1 6.9 5.7e-05 21.8 4.8 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein DUF3811 PF11656.3 ESL07131.1 - 0.014 15.4 1.7 0.014 15.4 1.2 2.7 1 1 1 2 2 2 0 YjbD family (DUF3811) NAM-associated PF14303.1 ESL07131.1 - 0.015 15.6 5.0 0.018 15.3 3.5 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Cob_adeno_trans PF01923.13 ESL07131.1 - 0.022 14.5 5.8 0.026 14.2 4.0 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Clusterin PF01093.12 ESL07131.1 - 0.044 12.5 3.8 0.2 10.4 0.0 2.0 1 1 1 2 2 2 0 Clusterin MRP-S27 PF10037.4 ESL07131.1 - 0.055 12.3 2.7 0.061 12.2 1.8 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Bacillus_HBL PF05791.6 ESL07131.1 - 0.07 12.4 0.3 0.31 10.3 0.1 1.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Tup_N PF08581.5 ESL07131.1 - 0.094 12.9 5.0 0.87 9.8 1.7 2.4 2 0 0 2 2 2 0 Tup N-terminal SseC PF04888.7 ESL07131.1 - 0.13 11.5 1.0 0.14 11.5 0.7 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF4391 PF14335.1 ESL07131.1 - 0.15 11.4 2.7 0.2 11.0 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Apolipoprotein PF01442.13 ESL07131.1 - 0.23 10.9 14.1 0.29 10.6 9.8 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain KR PF08659.5 ESL07131.1 - 0.24 11.0 3.1 0.33 10.6 2.2 1.3 1 0 0 1 1 1 0 KR domain DUF1664 PF07889.7 ESL07131.1 - 0.36 10.6 4.3 3.7 7.3 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2317 PF10079.4 ESL07131.1 - 0.45 9.0 6.6 0.51 8.8 4.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) APG6 PF04111.7 ESL07131.1 - 0.58 9.1 7.7 0.71 8.8 5.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF641 PF04859.7 ESL07131.1 - 0.86 9.3 7.7 0.32 10.7 3.3 1.9 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF4404 PF14357.1 ESL07131.1 - 1.7 9.0 9.7 1.9 8.9 3.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Iron_permease PF04120.7 ESL07131.1 - 2.1 7.9 4.5 2.1 7.9 2.6 1.5 1 1 0 1 1 1 0 Low affinity iron permease ERM PF00769.14 ESL07131.1 - 2.2 7.7 15.3 4 6.9 10.6 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family CorA PF01544.13 ESL07131.1 - 2.3 7.1 6.1 2.8 6.8 4.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF16 PF01519.11 ESL07131.1 - 3.5 7.9 5.1 6.5 7.0 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4349 PF14257.1 ESL07131.1 - 5.2 6.2 12.1 15 4.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) HAUS6_N PF14661.1 ESL07131.1 - 6.5 6.0 8.9 7.6 5.8 6.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus SlyX PF04102.7 ESL07131.1 - 7.9 6.9 12.0 13 6.2 2.1 3.2 1 1 3 4 4 4 0 SlyX TPD52 PF04201.10 ESL07131.1 - 8.1 6.1 7.5 49 3.6 0.3 2.2 1 1 1 2 2 2 0 Tumour protein D52 family DSPc PF00782.15 ESL07132.1 - 1.6e-18 66.6 0.1 6.4e-18 64.6 0.0 2.0 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain AAA PF00004.24 ESL07133.1 - 2.4e-43 147.4 0.0 5.3e-43 146.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL07133.1 - 4.3e-08 33.3 0.5 0.00023 21.2 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 ESL07133.1 - 6.1e-07 29.2 0.0 3.3e-06 26.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESL07133.1 - 6.2e-07 29.6 0.3 0.00033 20.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESL07133.1 - 3.6e-06 27.0 0.0 7.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ESL07133.1 - 1.2e-05 24.5 0.0 2.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESL07133.1 - 1.4e-05 24.5 0.3 0.0024 17.3 0.1 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.8 ESL07133.1 - 0.00021 20.3 0.0 0.00042 19.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESL07133.1 - 0.00025 20.7 0.1 0.00067 19.3 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 ESL07133.1 - 0.00055 20.2 0.1 0.0028 17.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESL07133.1 - 0.00058 19.7 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL07133.1 - 0.00074 20.3 0.5 0.0022 18.8 0.1 2.2 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESL07133.1 - 0.00083 18.8 0.0 0.0019 17.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 ESL07133.1 - 0.0015 17.3 0.0 0.0029 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus RNA_helicase PF00910.17 ESL07133.1 - 0.0015 18.6 0.0 0.0039 17.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 ESL07133.1 - 0.0023 17.1 0.0 0.0046 16.1 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.12 ESL07133.1 - 0.0036 16.2 0.0 0.0068 15.3 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 ESL07133.1 - 0.0062 16.2 0.2 0.1 12.2 0.0 2.5 2 1 0 2 2 2 1 Archaeal ATPase KaiC PF06745.8 ESL07133.1 - 0.0082 15.2 0.7 0.13 11.3 0.0 2.7 2 1 1 3 3 3 1 KaiC AAA_24 PF13479.1 ESL07133.1 - 0.0087 15.6 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 ESL07133.1 - 0.0097 15.5 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESL07133.1 - 0.017 14.5 0.1 0.081 12.3 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.7 ESL07133.1 - 0.018 14.7 0.0 0.085 12.5 0.0 2.0 1 1 1 2 2 2 0 NACHT domain ABC_tran PF00005.22 ESL07133.1 - 0.019 15.2 0.1 0.15 12.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.1 ESL07133.1 - 0.021 14.7 0.0 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL07133.1 - 0.022 14.6 0.0 0.09 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESL07133.1 - 0.034 13.2 0.1 0.088 11.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 ESL07133.1 - 0.042 13.0 0.1 0.12 11.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein UPF0079 PF02367.12 ESL07133.1 - 0.067 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activ_2 PF14532.1 ESL07133.1 - 0.074 13.1 0.1 0.23 11.5 0.0 2.0 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_11 PF13086.1 ESL07133.1 - 0.091 12.3 1.1 0.41 10.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 ESL07133.1 - 0.53 10.5 3.8 3.6 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Chol_subst-bind PF09129.6 ESL07134.1 - 0.017 14.2 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 Cholesterol oxidase, substrate-binding Acyl-CoA_dh_1 PF00441.19 ESL07134.1 - 0.28 11.2 4.0 0.42 10.7 0.5 2.3 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain SET PF00856.23 ESL07135.1 - 2.9e-13 50.4 0.0 1.6e-12 48.0 0.0 2.0 1 1 0 1 1 1 1 SET domain MMR_HSR1 PF01926.18 ESL07136.1 - 9.4e-38 128.7 0.0 1.3e-17 63.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL07136.1 - 7.8e-22 77.6 0.0 3e-11 43.0 0.0 3.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESL07136.1 - 2.7e-16 59.2 0.0 2.1e-08 33.5 0.0 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.18 ESL07136.1 - 5.9e-16 58.7 0.1 5.4e-05 23.0 0.0 4.3 3 1 1 4 4 4 3 Dynamin family KH_dom-like PF14714.1 ESL07136.1 - 1.6e-15 56.7 0.3 3.5e-15 55.7 0.2 1.6 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal Miro PF08477.8 ESL07136.1 - 2.5e-13 50.5 0.0 3.1e-06 27.6 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AIG1 PF04548.11 ESL07136.1 - 5.7e-13 48.4 0.0 2.6e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 AIG1 family SRPRB PF09439.5 ESL07136.1 - 6.4e-10 38.5 0.0 4.5e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit DUF258 PF03193.11 ESL07136.1 - 8e-08 31.6 0.0 0.0076 15.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Ras PF00071.17 ESL07136.1 - 1.2e-06 28.0 0.0 0.00033 20.0 0.0 2.7 2 1 0 2 2 2 1 Ras family PduV-EutP PF10662.4 ESL07136.1 - 2.3e-06 27.1 0.0 0.011 15.2 0.0 3.3 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 ESL07136.1 - 1.6e-05 25.2 0.0 0.2 11.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter MobB PF03205.9 ESL07136.1 - 3.4e-05 23.5 0.0 0.069 12.8 0.0 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 ESL07136.1 - 0.00012 22.3 0.0 0.68 10.2 0.0 2.9 2 1 0 2 2 2 2 AAA domain GBP PF02263.14 ESL07136.1 - 0.00023 20.3 0.0 0.49 9.4 0.0 2.3 2 0 0 2 2 2 2 Guanylate-binding protein, N-terminal domain IIGP PF05049.8 ESL07136.1 - 0.0016 17.2 0.0 0.12 11.1 0.0 2.5 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_17 PF13207.1 ESL07136.1 - 0.0028 18.4 0.4 4.7 8.0 0.0 3.5 2 2 0 2 2 2 1 AAA domain Septin PF00735.13 ESL07136.1 - 0.0033 16.4 0.0 0.36 9.8 0.0 2.4 2 0 0 2 2 2 1 Septin AAA_29 PF13555.1 ESL07136.1 - 0.0035 16.8 0.0 2.2 7.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_10 PF12846.2 ESL07136.1 - 0.011 15.1 0.0 2.6 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain Arch_ATPase PF01637.13 ESL07136.1 - 0.02 14.5 0.0 4.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Archaeal ATPase YqgF PF14639.1 ESL07138.1 - 1.8e-12 47.0 0.0 5.7e-12 45.4 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SH2_2 PF14633.1 ESL07138.1 - 1.6e-08 33.8 0.0 2.7e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 SH2 domain HHH_7 PF14635.1 ESL07138.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif 2H-phosphodiest PF08975.5 ESL07141.1 - 0.11 12.2 0.1 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) Flagellar_rod PF05149.7 ESL07142.1 - 1e-10 41.3 23.5 1e-10 41.3 16.3 2.3 3 0 0 3 3 3 1 Paraflagellar rod protein DUF4319 PF14203.1 ESL07142.1 - 0.022 14.3 0.7 0.082 12.4 0.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4319) DUF2383 PF09537.5 ESL07142.1 - 6.9 6.9 9.7 0.75 10.0 0.0 3.9 4 1 1 5 5 5 0 Domain of unknown function (DUF2383) WD40 PF00400.27 ESL07143.1 - 6.8e-15 54.2 13.0 0.023 14.5 0.0 7.9 9 0 0 9 9 9 5 WD domain, G-beta repeat ELK PF03789.8 ESL07143.1 - 0.0096 15.6 0.5 0.11 12.2 0.0 3.1 3 0 0 3 3 3 1 ELK domain DUF948 PF06103.6 ESL07143.1 - 0.054 13.3 2.8 6.4 6.7 0.0 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 ESL07143.1 - 0.15 11.1 5.2 3.7 6.6 0.6 3.0 2 1 1 3 3 3 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 ESL07144.1 - 0.0089 15.7 9.5 0.0089 15.7 6.6 4.3 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein MCPsignal PF00015.16 ESL07144.1 - 0.026 14.0 0.1 0.026 14.0 0.1 2.4 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF342 PF03961.8 ESL07144.1 - 0.27 9.6 9.8 0.65 8.3 2.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF342) ThiS PF02597.15 ESL07144.1 - 0.86 10.0 5.8 11 6.5 0.0 4.2 3 1 1 4 4 4 0 ThiS family F_actin_bind PF08919.5 ESL07144.1 - 1.4 8.6 6.0 0.76 9.5 1.5 2.6 2 1 0 2 2 2 0 F-actin binding HlyD_2 PF12700.2 ESL07144.1 - 2 7.4 6.9 1.3 8.1 2.3 2.1 2 0 0 2 2 2 0 HlyD family secretion protein DUF972 PF06156.8 ESL07144.1 - 2.6 8.4 26.8 2.4 8.5 0.1 5.0 3 2 1 4 4 4 0 Protein of unknown function (DUF972) Herpes_UL6 PF01763.11 ESL07144.1 - 6.9 4.7 10.6 0.63 8.1 3.9 1.8 1 1 1 2 2 2 0 Herpesvirus UL6 like Scm3 PF10384.4 ESL07145.1 - 0.064 12.7 0.3 2 7.9 0.0 2.9 3 0 0 3 3 3 0 Centromere protein Scm3 DUF4404 PF14357.1 ESL07145.1 - 0.24 11.8 4.5 1.2 9.6 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4404) Kinesin PF00225.18 ESL07146.1 - 4.8e-104 347.6 0.0 4.8e-104 347.6 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain HAUS5 PF14817.1 ESL07146.1 - 0.0017 17.0 11.3 0.0023 16.5 7.8 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 DUF3573 PF12097.3 ESL07146.1 - 0.16 10.5 6.1 0.13 10.8 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) TMF_DNA_bd PF12329.3 ESL07146.1 - 0.3 10.9 18.5 0.3 10.9 6.0 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.1 ESL07146.1 - 0.95 7.8 9.8 2 6.7 6.8 1.4 1 0 0 1 1 1 0 AAA domain DUF904 PF06005.7 ESL07146.1 - 1.1 9.6 16.1 1.6e+03 -0.6 11.2 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Fib_alpha PF08702.5 ESL07146.1 - 1.8 8.6 10.5 10 6.2 6.3 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.7 ESL07146.1 - 2.3 8.6 17.1 5.9 7.3 5.5 3.3 1 1 2 3 3 3 0 SlyX GAS PF13851.1 ESL07146.1 - 2.6 7.1 17.6 1.1 8.4 6.6 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.1 ESL07146.1 - 5.3 7.0 19.3 1.5 8.8 4.9 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) LSM PF01423.17 ESL07147.1 - 3.7e-18 64.8 0.0 4.2e-18 64.6 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESL07147.1 - 2.5e-05 24.0 0.0 2.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.2 ESL07147.1 - 0.094 12.5 0.0 0.12 12.1 0.0 1.4 1 1 0 1 1 1 0 Scd6-like Sm domain Pkinase PF00069.20 ESL07148.1 - 1.5e-54 184.8 0.0 1.8e-54 184.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07148.1 - 3.4e-37 127.9 0.0 4.2e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_3 PF08239.6 ESL07148.1 - 9.3e-06 25.7 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Kinase-like PF14531.1 ESL07148.1 - 1.5e-05 24.1 0.0 9.5e-05 21.4 0.0 2.1 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESL07148.1 - 0.045 13.4 0.0 1.9 8.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family SH3_5 PF08460.5 ESL07148.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain UIM PF02809.15 ESL07149.1 - 7.3e-09 34.4 8.9 0.00048 19.4 2.6 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif VWA_2 PF13519.1 ESL07149.1 - 0.00015 21.9 0.1 0.00023 21.3 0.0 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain KH_5 PF13184.1 ESL07149.1 - 0.078 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 NusA-like KH domain MUG2_C PF08593.5 ESL07149.1 - 0.081 13.1 0.1 0.23 11.7 0.1 1.8 1 0 0 1 1 1 0 Meiotically up-regulated glycoproteins C-terminal CS PF04969.11 ESL07150.1 - 1e-10 42.0 0.0 1.7e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 CS domain Rhabdo_ncap_2 PF03216.8 ESL07151.1 - 0.11 11.1 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein FKBP_C PF00254.23 ESL07152.1 - 2.3e-27 94.8 0.0 2.6e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF155 PF02582.9 ESL07153.1 - 1.4e-37 129.3 0.0 2e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 HA2 PF04408.18 ESL07154.1 - 1.2e-23 83.0 0.0 2.2e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESL07154.1 - 1.3e-16 60.4 0.0 3.2e-16 59.1 0.0 1.7 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESL07154.1 - 2.7e-13 49.5 0.0 6.5e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL07154.1 - 1.3e-07 31.3 0.1 5.8e-07 29.1 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESL07154.1 - 8.6e-06 25.9 0.0 2.4e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESL07154.1 - 0.00072 18.5 0.0 0.0016 17.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.22 ESL07154.1 - 0.045 14.0 0.1 0.52 10.5 0.0 2.3 1 1 0 1 1 1 0 ABC transporter SRP54 PF00448.17 ESL07154.1 - 0.055 12.8 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.1 ESL07154.1 - 0.062 12.8 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.10 ESL07154.1 - 0.066 13.0 0.6 13 5.5 0.0 2.6 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESL07154.1 - 0.088 12.7 0.3 0.77 9.7 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 ESL07154.1 - 0.11 11.6 0.1 0.36 9.8 0.0 1.9 1 1 1 2 2 2 0 Zeta toxin KaiC PF06745.8 ESL07154.1 - 0.15 11.1 0.0 0.27 10.2 0.0 1.4 1 0 0 1 1 1 0 KaiC Zot PF05707.7 ESL07154.1 - 0.16 11.3 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) G-alpha PF00503.15 ESL07154.1 - 0.19 10.3 0.0 0.32 9.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Cortex-I_coil PF09304.5 ESL07155.1 - 0.012 15.6 1.6 0.02 14.9 1.1 1.3 1 0 0 1 1 1 0 Cortexillin I, coiled coil SDP_N PF12278.3 ESL07155.1 - 0.026 14.1 0.1 0.045 13.3 0.1 1.3 1 0 0 1 1 1 0 Sex determination protein N terminal SAC3_GANP PF03399.11 ESL07156.1 - 0.00033 20.2 0.5 0.0033 17.0 0.0 2.4 2 1 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SNF2_N PF00176.18 ESL07157.1 - 2.4e-29 102.1 0.0 3.8e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL07157.1 - 5.3e-06 26.2 0.0 1.1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL07157.1 - 1.3e-05 24.7 0.0 2.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESL07157.1 - 0.0018 18.1 0.0 0.0082 15.9 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 ESL07157.1 - 0.052 12.5 0.0 0.074 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Ecotin PF03974.8 ESL07158.1 - 1.3e-38 131.5 0.1 1.6e-38 131.2 0.1 1.0 1 0 0 1 1 1 1 Ecotin Exo_endo_phos PF03372.18 ESL07160.1 - 1.5e-15 57.8 0.2 3.6e-15 56.5 0.2 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GspL_C PF12693.2 ESL07160.1 - 0.081 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 GspL periplasmic domain Exo_endo_phos PF03372.18 ESL07161.1 - 2.2e-13 50.7 0.0 4.1e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TrbC PF04956.8 ESL07162.1 - 0.07 13.1 0.4 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family IU_nuc_hydro PF01156.14 ESL07163.1 - 1.4e-54 185.4 0.0 1.7e-54 185.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Mannosyl_trans PF05007.8 ESL07164.1 - 3.2e-86 289.1 13.9 6e-86 288.2 9.6 1.4 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 ESL07164.1 - 4.5e-10 38.9 24.0 4.5e-10 38.9 16.6 1.6 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 ESL07164.1 - 8.9e-08 31.9 16.7 8.9e-08 31.9 11.6 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2029) PsbT PF01405.12 ESL07164.1 - 4 7.1 7.5 2 8.0 0.9 3.2 2 1 0 2 2 2 0 Photosystem II reaction centre T protein MFS_1 PF07690.11 ESL07165.1 - 1.6e-23 82.9 7.1 1.9e-23 82.7 4.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESL07165.1 - 0.00052 18.7 7.3 0.00061 18.4 5.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter BT1 PF03092.11 ESL07165.1 - 0.0057 15.4 0.6 0.0094 14.7 0.2 1.6 1 1 1 2 2 2 1 BT1 family Gar1 PF04410.9 ESL07165.1 - 0.019 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region ATG22 PF11700.3 ESL07165.1 - 0.85 8.0 9.0 1.6 7.1 6.3 1.4 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like Ribosomal_S3_C PF00189.15 ESL07166.1 - 1.7e-16 60.2 0.9 3.5e-16 59.1 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 ESL07166.1 - 6.7e-09 35.1 0.1 1.4e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 KH domain FAD_binding_1 PF00667.15 ESL07168.1 - 3.1e-32 111.7 0.0 1.1e-29 103.4 0.0 2.6 2 1 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.20 ESL07168.1 - 6.6e-20 71.5 0.0 1.8e-18 66.8 0.0 2.3 1 1 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 ESL07168.1 - 4.8e-06 27.1 0.0 1.5e-05 25.4 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL07168.1 - 0.0026 17.8 0.0 0.0055 16.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain PQQ_3 PF13570.1 ESL07169.1 - 0.49 10.7 3.4 1.4 9.2 1.0 2.6 1 1 1 2 2 2 0 PQQ-like domain Ank PF00023.25 ESL07170.1 - 5.4e-05 22.7 1.5 0.35 10.7 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 ESL07170.1 - 0.0018 18.5 0.2 5.9 7.3 0.0 3.6 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL07170.1 - 0.08 13.4 0.1 3.3 8.3 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL07170.1 - 0.096 12.9 0.0 30 5.2 0.0 3.4 2 0 0 2 2 2 0 Ankyrin repeat HEAT_2 PF13646.1 ESL07171.1 - 0.032 14.5 0.2 0.032 14.5 0.1 4.2 4 1 2 6 6 6 0 HEAT repeats HEAT PF02985.17 ESL07171.1 - 2.1 8.6 6.8 3 8.1 0.1 4.7 4 0 0 4 4 4 0 HEAT repeat Ribosomal_S25 PF03297.10 ESL07172.1 - 1.8e-36 124.3 4.5 2e-36 124.2 3.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein RNA_pol_Rpc34 PF05158.7 ESL07172.1 - 0.044 12.9 0.2 0.046 12.9 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit EAP30 PF04157.11 ESL07172.1 - 0.088 11.9 0.0 6.9 5.7 0.0 2.0 1 1 1 2 2 2 0 EAP30/Vps36 family DUF3516 PF12029.3 ESL07172.1 - 0.11 11.3 0.4 0.11 11.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) zf-CCCH PF00642.19 ESL07173.1 - 6.3e-05 22.5 9.3 7.2e-05 22.3 2.4 3.2 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESL07173.1 - 6.2 6.9 8.7 20 5.4 2.6 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type 6PF2K PF01591.13 ESL07174.1 - 3e-30 104.9 0.0 4.1e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Ank_2 PF12796.2 ESL07174.1 - 1.3e-17 63.9 0.1 1e-16 61.0 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) His_Phos_1 PF00300.17 ESL07174.1 - 2.3e-15 57.0 0.0 4.7e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ank PF00023.25 ESL07174.1 - 5.7e-14 51.1 0.7 5.2e-09 35.4 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESL07174.1 - 1e-10 41.5 0.1 9.2e-10 38.4 0.0 2.6 2 1 1 3 3 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESL07174.1 - 2.9e-09 37.2 0.1 7.8e-07 29.4 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) AAA_33 PF13671.1 ESL07174.1 - 3.2e-06 27.0 0.0 6.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Ank_3 PF13606.1 ESL07174.1 - 4.5e-06 26.3 0.0 8.6e-05 22.4 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat KTI12 PF08433.5 ESL07174.1 - 3.8e-05 23.0 0.0 8.1e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 ESL07174.1 - 0.00023 21.9 0.0 0.0016 19.2 0.0 2.3 2 1 1 3 3 2 1 AAA domain AAA_5 PF07728.9 ESL07174.1 - 0.00063 19.4 0.0 0.0016 18.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ESL07174.1 - 0.0014 17.8 0.0 0.0028 16.7 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA PF00004.24 ESL07174.1 - 0.025 14.8 0.0 0.22 11.7 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL07174.1 - 0.083 13.0 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESL07174.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain CSD PF00313.17 ESL07176.1 - 1.9e-10 40.3 0.1 4.2e-07 29.6 0.0 2.3 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain ThiF PF00899.16 ESL07177.1 - 3e-33 114.5 0.1 7.3e-33 113.2 0.1 1.6 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 ESL07177.1 - 1.3e-32 111.2 3.8 8e-27 92.6 0.4 2.8 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ESL07177.1 - 1.3e-15 56.4 0.0 2.6e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Rhamno_transf PF11316.3 ESL07177.1 - 0.0037 16.4 0.5 0.022 13.9 0.1 2.1 2 0 0 2 2 2 1 Putative rhamnosyl transferase Arm PF00514.18 ESL07179.1 - 2.3e-62 204.8 14.6 2.9e-09 36.4 0.0 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 ESL07179.1 - 1e-18 67.2 1.6 0.0047 17.3 0.0 6.5 6 2 1 7 7 7 5 HEAT-like repeat HEAT_2 PF13646.1 ESL07179.1 - 1.5e-15 57.2 0.0 2.4e-05 24.5 0.0 5.6 1 1 6 7 7 7 6 HEAT repeats HEAT PF02985.17 ESL07179.1 - 1.3e-12 46.6 2.1 0.79 9.9 0.0 7.5 7 1 0 7 7 7 4 HEAT repeat RICTOR_V PF14668.1 ESL07179.1 - 2.6e-05 24.0 1.8 0.41 10.6 0.0 5.1 4 2 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_PBS PF03130.11 ESL07179.1 - 0.06 13.8 3.4 48 4.8 0.1 5.5 5 2 0 5 5 5 0 PBS lyase HEAT-like repeat CECR6_TMEM121 PF14997.1 ESL07181.1 - 2.5e-08 33.7 0.3 2.5e-08 33.7 0.2 3.0 3 1 0 3 3 3 1 CECR6/TMEM121 family LRR_4 PF12799.2 ESL07182.1 - 1e-30 104.7 24.1 1.1e-10 40.8 0.4 6.8 5 2 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL07182.1 - 1e-16 60.4 25.9 3.4e-07 29.9 0.6 6.3 4 2 2 6 6 6 4 Leucine rich repeat LRR_1 PF00560.28 ESL07182.1 - 1.2e-13 49.0 25.8 0.2 11.8 0.1 10.2 10 0 0 10 10 10 5 Leucine Rich Repeat LRR_9 PF14580.1 ESL07182.1 - 3e-12 46.4 11.1 0.00016 21.3 1.4 5.2 1 1 4 5 5 5 4 Leucine-rich repeat LRR_7 PF13504.1 ESL07182.1 - 7.1e-10 37.4 15.2 0.36 11.2 0.0 9.1 9 1 1 10 10 10 2 Leucine rich repeat LRR_6 PF13516.1 ESL07182.1 - 1.1e-09 37.3 17.9 0.41 10.8 0.0 9.7 7 3 3 10 10 10 3 Leucine Rich repeat DUF310 PF03750.8 ESL07182.1 - 0.016 15.3 0.0 0.042 14.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF310) DnaJ PF00226.26 ESL07183.1 - 5.9e-19 67.5 0.1 1e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Prok-JAB PF14464.1 ESL07183.1 - 0.073 12.6 0.6 0.14 11.6 0.4 1.5 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain DnaJ PF00226.26 ESL07184.1 - 2.2e-15 56.1 0.2 4.5e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain BBS2_C PF14782.1 ESL07185.1 - 3.7e-130 434.3 0.0 5e-130 433.9 0.0 1.1 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_N PF14781.1 ESL07185.1 - 5.4e-34 116.7 0.0 1.2e-33 115.6 0.0 1.6 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, N-terminal BBS2_Mid PF14783.1 ESL07185.1 - 1.3e-32 111.8 0.0 5.1e-32 109.9 0.0 2.0 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.18 ESL07185.1 - 0.077 12.7 0.0 0.22 11.2 0.0 1.8 1 0 0 1 1 1 0 FG-GAP repeat CENP-Q PF13094.1 ESL07185.1 - 0.085 12.8 1.2 8.9 6.3 0.1 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit C2 PF00168.25 ESL07186.1 - 2.9e-12 46.2 0.0 1.3e-11 44.2 0.0 2.1 2 0 0 2 2 2 1 C2 domain DUF2404 PF10296.4 ESL07186.1 - 0.022 14.8 0.0 0.17 11.9 0.0 2.5 2 0 0 2 2 2 0 Putative integral membrane protein conserved region (DUF2404) Frizzled PF01534.12 ESL07186.1 - 0.095 11.4 0.3 0.35 9.5 0.2 1.8 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region SLX9 PF15341.1 ESL07187.1 - 7.3e-07 29.6 5.4 1.7e-06 28.4 3.7 1.7 1 1 0 1 1 1 1 Ribosome biogenesis protein SLX9 Plasmodium_Vir PF05795.6 ESL07189.1 - 0.87 8.7 1.4 1.1 8.3 0.0 1.8 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Adeno_E3_14_5 PF04834.7 ESL07189.1 - 1 9.8 0.0 1 9.8 0.0 3.8 4 1 0 4 4 4 0 Early E3 14.5 kDa protein Phage_Gp23 PF10669.4 ESL07189.1 - 3.9 7.5 5.5 27 4.8 1.7 2.5 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) BCAS2 PF05700.6 ESL07190.1 - 1.3 8.4 5.9 8.1 5.8 0.1 2.2 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) DUF2269 PF10027.4 ESL07191.1 - 0.076 12.7 6.1 0.096 12.4 4.3 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) FA_desaturase PF00487.19 ESL07191.1 - 0.17 11.2 3.4 0.21 11.0 2.4 1.1 1 0 0 1 1 1 0 Fatty acid desaturase Ank_2 PF12796.2 ESL07192.1 - 1.9e-27 95.4 2.3 9.6e-13 48.2 1.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESL07192.1 - 5.4e-24 82.7 13.2 7.4e-06 25.5 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.1 ESL07192.1 - 9.9e-23 79.6 10.2 2.5e-08 33.9 0.0 5.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESL07192.1 - 2.1e-22 79.0 3.1 3.1e-06 27.5 0.1 6.2 4 2 2 6 6 6 5 Ankyrin repeats (many copies) zf-DHHC PF01529.15 ESL07192.1 - 2.6e-17 62.7 0.0 5.3e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ank_3 PF13606.1 ESL07192.1 - 8.9e-17 59.5 8.9 0.0023 18.0 0.0 7.1 6 1 0 6 6 6 5 Ankyrin repeat CK_II_beta PF01214.13 ESL07192.1 - 0.19 11.1 0.3 0.32 10.4 0.2 1.2 1 0 0 1 1 1 0 Casein kinase II regulatory subunit zf-HIT PF04438.11 ESL07193.1 - 2.6e-06 26.9 9.1 5.2e-06 25.9 6.3 1.4 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.13 ESL07193.1 - 0.14 12.0 8.5 0.38 10.6 5.9 1.8 1 0 0 1 1 1 0 MYND finger zf-CCHC PF00098.18 ESL07194.1 - 1.2e-25 88.1 70.4 0.0003 20.5 0.3 11.1 12 0 0 12 12 12 9 Zinc knuckle NYN PF01936.13 ESL07194.1 - 3.3e-07 30.7 0.0 1.2e-06 28.8 0.0 1.9 1 1 0 1 1 1 1 NYN domain zf-CCHC_2 PF13696.1 ESL07194.1 - 2.2e-06 27.0 47.4 0.00023 20.5 1.4 7.6 3 2 4 7 7 7 6 Zinc knuckle zf-CCHC_4 PF14392.1 ESL07194.1 - 0.027 14.1 62.6 0.11 12.2 1.8 9.2 8 1 1 9 9 9 0 Zinc knuckle Methyltransf_PK PF05891.7 ESL07195.1 - 4e-63 212.6 0.0 4.9e-63 212.3 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_11 PF08241.7 ESL07195.1 - 1.4e-08 35.1 0.0 2.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL07195.1 - 1.9e-05 24.2 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESL07195.1 - 0.00031 20.0 0.0 0.00037 19.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 ESL07195.1 - 0.0006 20.3 0.0 0.001 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL07195.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESL07195.1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_12 PF08242.7 ESL07195.1 - 0.0025 18.2 0.0 0.0042 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL07195.1 - 0.0091 16.3 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Succ_CoA_lig PF13607.1 ESL07195.1 - 0.022 14.3 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain MTS PF05175.9 ESL07195.1 - 0.15 11.4 0.0 0.36 10.1 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase small domain Actin PF00022.14 ESL07196.1 - 4.1e-68 229.6 0.0 4.9e-68 229.3 0.0 1.1 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESL07196.1 - 0.0098 14.5 0.0 0.014 14.0 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Seryl_tRNA_N PF02403.17 ESL07198.1 - 0.0041 17.1 1.3 0.0041 17.1 0.9 6.3 3 2 5 8 8 8 3 Seryl-tRNA synthetase N-terminal domain DUF4373 PF14297.1 ESL07198.1 - 0.062 13.6 0.0 0.9 9.8 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) zf-C2H2 PF00096.21 ESL07198.1 - 0.18 12.2 0.1 0.42 11.0 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESL07198.1 - 0.24 11.5 0.0 0.45 10.6 0.0 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding RNA_pol_N PF01194.12 ESL07199.1 - 9.9e-27 92.7 0.7 9.9e-27 92.7 0.5 1.5 2 0 0 2 2 2 1 RNA polymerases N / 8 kDa subunit Yippee-Mis18 PF03226.9 ESL07199.1 - 0.26 11.3 4.1 0.72 9.9 2.8 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Calreticulin PF00262.13 ESL07200.1 - 5.4e-112 374.0 8.1 8.2e-112 373.4 5.6 1.3 1 0 0 1 1 1 1 Calreticulin family PBP_sp32 PF07222.7 ESL07200.1 - 6.1 5.9 8.6 9.7 5.2 5.9 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 eIF3_subunit PF08597.5 ESL07202.1 - 1.2e-07 31.5 12.8 1.6e-07 31.1 8.9 1.2 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit BRF1 PF07741.8 ESL07202.1 - 4.2 7.6 12.1 4.7 7.4 0.2 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Ribosomal_L7Ae PF01248.21 ESL07206.1 - 2.9e-25 87.6 0.1 3.4e-25 87.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.1 ESL07206.1 - 0.00039 20.1 0.0 0.00051 19.7 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.6 ESL07206.1 - 0.00092 19.0 0.1 0.001 18.9 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PgaD PF13994.1 ESL07207.1 - 0.64 9.4 4.0 0.8 9.1 1.2 2.0 1 1 1 2 2 2 0 PgaD-like protein Methyltransf_11 PF08241.7 ESL07208.1 - 1.6e-10 41.3 0.0 9.5e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 ESL07208.1 - 1.9e-07 31.4 0.0 1.7e-06 28.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain WBS_methylT PF12589.3 ESL07208.1 - 4.1e-07 30.4 13.5 4.1e-07 30.4 9.4 2.9 3 1 0 3 3 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_31 PF13847.1 ESL07208.1 - 9.4e-07 28.5 0.0 2.8e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL07208.1 - 1.3e-06 28.7 0.0 9.5e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL07208.1 - 2.8e-06 27.1 0.0 4.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL07208.1 - 1.6e-05 25.4 0.1 2.8e-05 24.6 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL07208.1 - 5.3e-05 23.2 0.0 8.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESL07208.1 - 0.0034 16.9 0.0 0.0052 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 ESL07208.1 - 0.018 14.1 0.0 0.042 12.9 0.0 1.5 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.8 ESL07208.1 - 0.044 13.9 0.0 0.087 12.9 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase N6_N4_Mtase PF01555.13 ESL07208.1 - 0.099 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 DNA methylase NOA36 PF06524.7 ESL07208.1 - 0.51 9.5 6.6 0.91 8.7 1.9 2.1 2 0 0 2 2 2 0 NOA36 protein CTNNB1_binding PF08347.6 ESL07208.1 - 1.4 9.1 6.8 0.73 10.0 0.2 2.3 2 0 0 2 2 2 0 N-terminal CTNNB1 binding PGA2 PF07543.7 ESL07208.1 - 7.8 6.2 9.6 0.4 10.4 1.3 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 LRR_4 PF12799.2 ESL07209.1 - 3.7e-08 32.8 11.7 7.3e-06 25.4 2.6 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESL07209.1 - 5.7e-07 29.2 1.3 1.6e-06 27.8 0.9 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 ESL07209.1 - 4.3e-06 26.3 18.0 6.6e-05 22.5 1.6 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.1 ESL07209.1 - 0.0064 16.4 5.8 5.1 7.4 0.5 4.5 2 1 2 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.28 ESL07209.1 - 0.015 15.2 8.6 6.2 7.2 1.0 4.1 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_7 PF13504.1 ESL07209.1 - 1.3 9.5 11.3 14 6.4 0.7 4.5 4 1 1 5 5 5 0 Leucine rich repeat PMSR PF01625.16 ESL07210.1 - 6.3e-43 146.3 0.0 8.1e-43 145.9 0.0 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Suf PF05843.9 ESL07212.1 - 0.00013 21.8 0.3 0.056 13.1 0.1 3.2 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) TPR_14 PF13428.1 ESL07212.1 - 0.0014 19.0 8.5 2 9.3 0.0 6.0 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESL07212.1 - 0.0052 16.4 0.5 3.6 7.3 0.4 3.6 3 1 0 3 3 3 1 TPR repeat TPR_16 PF13432.1 ESL07212.1 - 0.006 17.2 2.7 4.5 8.0 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL07212.1 - 0.01 15.9 0.0 9.6 6.6 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07212.1 - 0.3 11.4 5.9 2.9 8.3 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat HSP70 PF00012.15 ESL07213.1 - 1.3e-112 376.7 0.0 1.6e-112 376.4 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL07213.1 - 4.1e-06 25.6 0.2 0.0028 16.3 0.0 2.6 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.1 ESL07213.1 - 4.7e-05 23.1 0.3 0.0017 18.1 0.0 2.8 2 1 0 2 2 2 1 Cell division protein FtsA Hydantoinase_A PF01968.13 ESL07213.1 - 0.36 9.8 2.1 0.88 8.6 0.3 2.4 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase IncA PF04156.9 ESL07214.1 - 0.038 13.5 0.2 0.039 13.5 0.2 1.1 1 0 0 1 1 1 0 IncA protein MMR_HSR1_C PF08438.5 ESL07215.1 - 9.9e-21 74.0 0.0 1.5e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 ESL07215.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase LexA_DNA_bind PF01726.11 ESL07215.1 - 0.14 11.7 0.0 0.55 9.8 0.0 2.0 2 0 0 2 2 2 0 LexA DNA binding domain ARL2_Bind_BART PF11527.3 ESL07216.1 - 1.4e-30 105.5 0.0 2.8e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART UIM PF02809.15 ESL07216.1 - 0.4 10.3 11.8 0.15 11.7 2.2 3.0 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF4565 PF15127.1 ESL07216.1 - 1.4 9.2 4.2 0.62 10.4 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4565) Kinesin PF00225.18 ESL07217.1 - 6.2e-92 307.8 0.0 4.6e-88 295.1 0.0 3.3 3 0 0 3 3 3 2 Kinesin motor domain WEMBL PF05701.6 ESL07217.1 - 0.00022 19.8 36.4 0.00022 19.8 25.3 3.8 4 0 0 4 4 4 1 Weak chloroplast movement under blue light CitMHS PF03600.11 ESL07220.1 - 0.089 11.3 1.0 0.1 11.1 0.7 1.2 1 0 0 1 1 1 0 Citrate transporter DUF4131 PF13567.1 ESL07220.1 - 8.5 5.7 7.4 12 5.2 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) WW PF00397.21 ESL07221.1 - 0.029 14.2 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 WW domain Ras PF00071.17 ESL07221.1 - 0.055 12.8 0.0 0.2 11.0 0.0 1.9 2 0 0 2 2 2 0 Ras family DUF1963 PF09234.5 ESL07221.1 - 1.3 9.1 6.3 0.91 9.7 2.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1963) Pkinase PF00069.20 ESL07223.1 - 6.4e-42 143.5 0.0 8.6e-42 143.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07223.1 - 1.1e-31 109.8 0.0 1.6e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07223.1 - 8e-10 38.1 0.0 1.2e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PH_9 PF15410.1 ESL07223.1 - 6.4e-09 35.9 0.1 3.3e-07 30.4 0.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESL07223.1 - 6.6e-09 35.9 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESL07223.1 - 2.4e-05 24.5 0.6 0.013 15.7 0.0 3.0 2 1 1 3 3 3 2 Pleckstrin homology domain BTB PF00651.26 ESL07225.1 - 3.5e-10 39.8 0.3 0.0017 18.3 0.1 3.1 2 1 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESL07225.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 BTB And C-terminal Kelch EmrE PF13536.1 ESL07226.1 - 0.042 14.0 29.1 0.05 13.7 9.4 3.0 3 0 0 3 3 3 0 Multidrug resistance efflux transporter Symplekin_C PF12295.3 ESL07228.1 - 0.00025 20.9 0.0 0.002 18.0 0.0 2.1 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal WD40 PF00400.27 ESL07229.1 - 0.58 10.1 5.2 4.7 7.2 0.1 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat INO80_Ies4 PF08193.6 ESL07229.1 - 2.3 8.1 12.2 0.21 11.4 1.3 2.2 2 0 0 2 2 2 0 INO80 complex subunit Ies4 zf-C3HC4_4 PF15227.1 ESL07230.1 - 3.9e-07 29.8 9.0 7.2e-07 28.9 6.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 ESL07230.1 - 4e-07 29.5 2.4 6.8e-07 28.8 1.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL07230.1 - 2.7e-06 26.9 4.6 4.6e-06 26.2 3.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL07230.1 - 5.9e-06 25.8 4.0 1.3e-05 24.6 2.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL07230.1 - 1e-05 25.4 7.7 1e-05 25.4 5.4 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESL07230.1 - 0.00027 20.5 2.7 0.00068 19.3 1.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 ESL07230.1 - 0.00072 19.3 7.7 0.00072 19.3 5.3 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_4 PF14570.1 ESL07230.1 - 0.013 15.0 1.5 0.026 14.0 1.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain HypA PF01155.14 ESL07230.1 - 0.064 12.9 1.1 0.21 11.2 0.8 1.9 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-RING_6 PF14835.1 ESL07230.1 - 0.19 11.5 3.6 0.48 10.2 2.5 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 ESL07230.1 - 0.21 11.7 1.9 0.48 10.5 1.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger RabGAP-TBC PF00566.13 ESL07231.1 - 6.4e-24 84.6 3.6 6.4e-24 84.6 2.5 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain AATF-Che1 PF13339.1 ESL07232.1 - 0.03 14.4 0.8 0.03 14.4 0.6 1.6 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor Amidohydro_4 PF13147.1 ESL07234.1 - 2.2e-25 90.2 3.4 4.5e-25 89.2 2.4 1.8 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 ESL07234.1 - 1.1e-15 58.1 0.1 5e-14 52.6 0.1 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 ESL07234.1 - 1.4e-12 47.5 6.0 1.6e-07 30.9 0.0 3.3 2 1 1 3 3 3 3 Amidohydrolase family Amidohydro_5 PF13594.1 ESL07234.1 - 9.8e-10 38.1 0.1 3.9e-09 36.1 0.1 2.1 1 1 0 1 1 1 1 Amidohydrolase zf-CCCH PF00642.19 ESL07235.1 - 7.2e-05 22.3 0.3 0.00012 21.6 0.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Adap_comp_sub PF00928.16 ESL07236.1 - 5e-79 265.0 0.0 6.3e-79 264.7 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESL07236.1 - 6.1e-05 22.7 0.2 9.8e-05 22.1 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain IQ PF00612.22 ESL07239.1 - 1.1e-06 27.6 58.3 0.0077 15.7 1.3 10.6 10 0 0 10 10 10 8 IQ calmodulin-binding motif SWIB PF02201.13 ESL07240.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 SWIB/MDM2 domain Kinesin PF00225.18 ESL07241.1 - 2.1e-19 69.4 0.0 1.3e-08 33.9 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain LdpA_C PF12617.3 ESL07241.1 - 0.0052 16.0 0.1 0.014 14.6 0.0 1.8 2 0 0 2 2 2 1 Iron-Sulfur binding protein C terminal NAD_binding_8 PF13450.1 ESL07243.1 - 1.7e-06 27.9 0.0 7.5e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESL07243.1 - 6.4e-05 22.9 0.0 0.0024 17.7 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESL07243.1 - 0.0001 22.5 0.0 0.13 12.6 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESL07243.1 - 0.0018 18.3 0.0 0.23 11.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESL07243.1 - 0.003 16.6 0.0 0.071 12.1 0.0 2.3 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.1 ESL07243.1 - 0.0033 17.2 0.0 0.008 15.9 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.19 ESL07243.1 - 0.04 12.8 0.0 0.3 9.9 0.0 2.4 3 0 0 3 3 3 0 FAD dependent oxidoreductase K_oxygenase PF13434.1 ESL07243.1 - 0.26 10.1 0.0 0.52 9.1 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) E1_dh PF00676.15 ESL07244.1 - 9.6e-84 280.6 0.0 1.1e-83 280.4 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 ESL07244.1 - 0.0007 18.6 0.2 0.0012 17.8 0.0 1.5 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase CoaE PF01121.15 ESL07246.1 - 9.2e-43 145.7 0.0 1.7e-42 144.8 0.0 1.4 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 ESL07246.1 - 0.00073 20.3 0.0 0.0012 19.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL07246.1 - 0.002 17.9 0.0 0.035 13.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain PRK PF00485.13 ESL07246.1 - 0.0082 15.7 0.1 2.7 7.5 0.0 2.2 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.1 ESL07246.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ldr_toxin PF13940.1 ESL07246.1 - 0.28 10.9 2.7 0.48 10.2 0.0 2.7 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system Med21 PF11221.3 ESL07247.1 - 0.0024 17.8 0.3 0.0024 17.8 0.2 4.5 5 1 2 7 7 7 1 Subunit 21 of Mediator complex Mga PF05043.8 ESL07247.1 - 0.014 15.6 0.5 0.067 13.4 0.2 2.4 1 1 0 1 1 1 0 Mga helix-turn-helix domain IFT46_B_C PF12317.3 ESL07247.1 - 3.6 6.8 7.4 0.82 8.9 2.3 2.0 2 1 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal PFU PF09070.6 ESL07248.1 - 1.9e-30 105.2 0.1 3e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 ESL07248.1 - 2.9e-30 103.0 27.0 6.8e-06 25.7 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat PUL PF08324.6 ESL07248.1 - 0.00041 19.2 0.0 0.00073 18.4 0.0 1.3 1 0 0 1 1 1 1 PUL domain EMP24_GP25L PF01105.19 ESL07248.1 - 0.042 13.5 0.1 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD ABC_tran PF00005.22 ESL07249.1 - 2.2e-17 63.6 0.0 1.3e-16 61.1 0.0 2.2 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL07249.1 - 2.5e-06 26.8 0.0 0.025 13.7 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESL07249.1 - 2.7e-06 27.5 0.0 0.0075 16.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ESL07249.1 - 2.3e-05 25.2 0.3 0.0001 23.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESL07249.1 - 9.9e-05 21.8 0.0 0.00059 19.3 0.0 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.1 ESL07249.1 - 0.00098 19.5 0.1 0.002 18.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL07249.1 - 0.0012 18.9 0.1 0.0078 16.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESL07249.1 - 0.071 12.2 0.0 0.27 10.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_19 PF13245.1 ESL07249.1 - 0.077 12.7 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 ESL07249.1 - 0.078 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL07249.1 - 0.08 12.8 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESL07249.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.12 ESL07249.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 SIS PF01380.17 ESL07250.1 - 8.9e-48 161.2 0.3 2.8e-25 88.4 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 ESL07250.1 - 7.7e-22 77.4 0.3 4.7e-15 55.1 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 ESL07250.1 - 8.2e-18 64.6 0.0 2.2e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 ESL07250.1 - 1.1e-11 44.5 0.0 2.8e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 ESL07250.1 - 5.8e-07 28.4 0.0 1.4e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 ESL07250.1 - 0.0025 17.5 0.1 0.011 15.4 0.0 2.1 2 0 0 2 2 2 1 SIS domain DUF4358 PF14270.1 ESL07250.1 - 0.086 12.7 0.1 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) NIF PF03031.13 ESL07251.1 - 1e-32 113.0 0.0 1.4e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.7 ESL07251.1 - 0.074 12.0 0.0 0.13 11.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF705) HAD_2 PF13419.1 ESL07251.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL07251.1 - 0.12 12.4 0.1 0.18 11.9 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Mito_carr PF00153.22 ESL07252.1 - 3e-60 199.9 1.0 9.6e-22 76.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PCIF1_WW PF12237.3 ESL07253.1 - 2.8e-49 166.7 0.0 4.4e-49 166.1 0.0 1.3 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain cNMP_binding PF00027.24 ESL07254.1 - 5.7e-10 38.8 0.0 7.8e-07 28.8 0.0 3.3 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain Sel1 PF08238.7 ESL07255.1 - 0.015 15.9 0.2 0.025 15.2 0.1 1.4 1 0 0 1 1 1 0 Sel1 repeat zf-C2H2_3 PF13878.1 ESL07256.1 - 3.1e-10 39.4 0.2 9.4e-10 37.8 0.1 1.9 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO IQ PF00612.22 ESL07257.1 - 3.5 7.5 15.2 4.3 7.2 2.7 3.8 3 0 0 3 3 3 0 IQ calmodulin-binding motif AAA_4 PF04326.9 ESL07258.1 - 5.8e-05 23.2 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 Divergent AAA domain DEAD PF00270.24 ESL07260.1 - 5.6e-41 139.8 0.1 1.6e-38 131.8 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL07260.1 - 1.6e-28 98.4 0.0 3.3e-28 97.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 ESL07260.1 - 0.0025 17.8 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain CMS1 PF14617.1 ESL07260.1 - 0.0036 16.3 0.0 0.0074 15.3 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit BMFP PF04380.8 ESL07260.1 - 0.12 12.5 1.4 23 5.2 0.0 3.6 2 1 1 3 3 3 0 Membrane fusogenic activity ResIII PF04851.10 ESL07260.1 - 0.12 12.1 0.0 0.84 9.4 0.0 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit MFS_1 PF07690.11 ESL07261.1 - 4.8e-29 101.1 21.1 4.4e-21 74.9 2.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESL07261.1 - 3.8e-06 25.7 20.8 5.3e-06 25.2 5.8 3.0 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.8 ESL07261.1 - 0.03 12.5 6.4 0.0061 14.8 2.0 1.5 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DUF3760 PF12586.3 ESL07261.1 - 0.16 11.8 0.4 22 5.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3760) XPC-binding PF09280.6 ESL07262.1 - 7.6e-19 66.9 2.9 1.8e-18 65.7 2.0 1.6 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.26 ESL07262.1 - 5e-13 48.4 1.6 6.5e-07 28.9 0.0 2.8 3 0 0 3 3 3 2 UBA/TS-N domain ubiquitin PF00240.18 ESL07262.1 - 3.4e-06 26.3 0.0 5.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESL07262.1 - 0.003 17.1 0.1 0.0062 16.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.5 ESL07262.1 - 0.07 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain DUF4266 PF14086.1 ESL07262.1 - 0.39 11.2 2.8 16 6.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) Mo25 PF08569.6 ESL07263.1 - 0.072 12.1 0.5 0.12 11.3 0.4 1.2 1 0 0 1 1 1 0 Mo25-like Pex2_Pex12 PF04757.9 ESL07265.1 - 9.4e-20 70.9 4.0 5.4e-16 58.7 2.8 2.3 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 ESL07265.1 - 8.3e-08 31.9 10.4 1.3e-07 31.2 7.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL07265.1 - 1.1e-07 31.7 10.7 1.6e-07 31.2 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL07265.1 - 1.4e-07 31.0 6.9 2.2e-07 30.4 4.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL07265.1 - 1.3e-06 27.9 9.6 2.1e-06 27.3 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL07265.1 - 2e-06 27.4 7.6 3.2e-06 26.7 5.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESL07265.1 - 2.1e-06 27.4 8.2 3.3e-06 26.8 5.7 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 ESL07265.1 - 0.00015 21.4 3.9 0.00026 20.7 2.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESL07265.1 - 0.00041 20.3 4.5 0.0007 19.6 3.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 ESL07265.1 - 0.0035 17.0 3.5 0.0074 15.9 2.2 1.7 1 1 0 1 1 1 1 RING-type zinc-finger Herpes_LMP1 PF05297.6 ESL07265.1 - 0.039 12.8 0.1 0.069 12.0 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) TerY-C PF15616.1 ESL07265.1 - 0.045 13.6 0.8 0.07 13.0 0.6 1.2 1 0 0 1 1 1 0 TerY-C metal binding domain zf-Nse PF11789.3 ESL07265.1 - 0.05 13.1 1.8 0.087 12.3 1.3 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Pex26 PF07163.7 ESL07265.1 - 0.08 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Pex26 protein zf-RING_4 PF14570.1 ESL07265.1 - 0.12 11.9 6.0 0.31 10.6 4.2 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.1 ESL07265.1 - 0.25 11.1 4.0 0.45 10.3 2.7 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FANCL_C PF11793.3 ESL07265.1 - 0.65 10.0 7.5 3.5 7.6 5.2 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.1 ESL07265.1 - 1.2 8.7 6.9 3.4 7.3 4.8 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 IBR PF01485.16 ESL07265.1 - 1.3 8.9 7.0 1.4 8.8 3.6 1.9 1 1 0 1 1 1 0 IBR domain CCDC-167 PF15188.1 ESL07266.1 - 0.051 13.5 0.3 0.085 12.8 0.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Actin PF00022.14 ESL07267.1 - 1.4e-07 30.3 0.5 0.047 12.1 0.1 3.0 3 0 0 3 3 3 3 Actin Ribosomal_L36e PF01158.13 ESL07268.1 - 2.2e-18 66.0 0.0 2.6e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e RNA_pol_Rpb2_6 PF00562.23 ESL07269.1 - 2.2e-121 405.2 0.0 3e-121 404.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 ESL07269.1 - 7.4e-41 139.3 0.0 1.1e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 ESL07269.1 - 3.7e-28 97.5 0.0 9.8e-28 96.2 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 ESL07269.1 - 5e-24 83.8 2.1 1e-23 82.8 1.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.9 ESL07269.1 - 1.9e-23 82.8 0.1 3.6e-23 81.9 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 ESL07269.1 - 6.5e-21 73.8 1.7 7.1e-21 73.7 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 ESL07269.1 - 1.3e-07 31.4 0.4 2.7e-07 30.4 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 OrfB_Zn_ribbon PF07282.6 ESL07269.1 - 0.25 11.0 4.6 0.15 11.7 1.5 1.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain FtsJ PF01728.14 ESL07270.1 - 1.5e-54 184.7 0.1 3.1e-54 183.7 0.1 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.3 ESL07270.1 - 1.1e-28 99.6 1.4 1.1e-28 99.6 1.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3381) SET PF00856.23 ESL07272.1 - 1.6e-09 38.2 0.0 7e-08 32.9 0.0 2.6 1 1 0 1 1 1 1 SET domain UBA PF00627.26 ESL07272.1 - 0.0078 16.0 0.1 1.4 8.8 0.0 2.4 2 0 0 2 2 2 2 UBA/TS-N domain NPR2 PF06218.6 ESL07273.1 - 0.0011 17.8 0.0 0.018 13.7 0.0 2.1 2 0 0 2 2 2 1 Nitrogen permease regulator 2 Olfactory_mark PF06554.7 ESL07273.1 - 0.0051 16.3 0.3 0.018 14.5 0.2 1.8 2 0 0 2 2 2 1 Olfactory marker protein Kinesin PF00225.18 ESL07275.1 - 5.3e-75 252.2 1.9 1.5e-43 148.8 0.0 3.1 3 0 0 3 3 3 2 Kinesin motor domain AAA_16 PF13191.1 ESL07275.1 - 0.2 11.6 2.5 34 4.3 0.0 3.4 3 0 0 3 3 3 0 AAA ATPase domain DUF3292 PF11696.3 ESL07276.1 - 0.013 13.3 0.4 0.018 12.9 0.2 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3292) Aa_trans PF01490.13 ESL07277.1 - 1.2e-12 47.0 7.1 1.3e-12 46.9 4.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF21 PF01595.15 ESL07277.1 - 0.34 10.1 2.6 0.46 9.7 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function DUF21 Cyd_oper_YbgE PF09600.5 ESL07277.1 - 0.49 10.5 8.3 3.1 8.0 0.6 2.2 2 0 0 2 2 2 0 Cyd operon protein YbgE (Cyd_oper_YbgE) RRM_1 PF00076.17 ESL07278.1 - 2.3e-39 132.8 0.3 5.9e-13 48.2 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL07278.1 - 2.5e-31 107.4 0.1 1e-10 41.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07278.1 - 5.8e-11 42.0 0.0 0.001 18.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESL07278.1 - 1.8e-07 30.8 0.0 0.034 13.9 0.0 3.1 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif DUF4651 PF15513.1 ESL07278.1 - 0.0016 17.8 0.0 6.4 6.3 0.0 3.6 3 0 0 3 3 3 2 Domain of unknown function (DUF4651) RRM_3 PF08777.6 ESL07278.1 - 0.0026 17.5 0.2 0.33 10.8 0.1 3.2 3 0 0 3 3 3 1 RNA binding motif zf-CCHC PF00098.18 ESL07278.1 - 0.0041 16.9 1.1 0.0041 16.9 0.7 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.1 ESL07278.1 - 0.013 15.1 0.4 0.028 14.1 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle Smg4_UPF3 PF03467.10 ESL07278.1 - 0.018 15.0 0.1 0.63 10.0 0.0 2.9 3 0 0 3 3 3 0 Smg-4/UPF3 family DNA_ligase_IV PF11411.3 ESL07278.1 - 0.88 9.3 0.0 0.88 9.3 0.0 4.3 5 0 0 5 5 5 0 DNA ligase IV ERO1 PF04137.10 ESL07279.1 - 2.3e-96 322.9 0.3 2.9e-96 322.5 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) OpgC_C PF10129.4 ESL07280.1 - 0.0031 16.2 0.6 0.0041 15.8 0.4 1.2 1 0 0 1 1 1 1 OpgC protein TPR_19 PF14559.1 ESL07281.1 - 0.0064 16.8 0.6 0.016 15.4 0.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat Microtub_assoc PF07989.6 ESL07281.1 - 0.018 14.8 2.2 0.037 13.8 1.5 1.5 1 0 0 1 1 1 0 Microtubule associated Fis1_TPR_C PF14853.1 ESL07281.1 - 0.043 13.7 0.3 0.17 11.8 0.2 2.0 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.1 ESL07281.1 - 0.059 14.0 1.4 0.18 12.5 0.9 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat RabGAP-TBC PF00566.13 ESL07282.1 - 4.1e-24 85.2 1.8 1e-22 80.6 1.1 2.5 2 1 0 2 2 2 1 Rab-GTPase-TBC domain TRAM1 PF08390.6 ESL07282.1 - 0.037 13.5 0.1 0.078 12.4 0.1 1.6 1 0 0 1 1 1 0 TRAM1-like protein Peptidase_M41 PF01434.13 ESL07283.1 - 5.7e-43 146.8 2.7 9.1e-43 146.2 1.9 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESL07283.1 - 3.6e-39 133.9 0.0 7.8e-39 132.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL07283.1 - 0.00011 22.9 0.1 0.00073 20.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL07283.1 - 0.00034 20.3 0.4 0.0023 17.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESL07283.1 - 0.00035 20.7 0.1 0.0042 17.2 0.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL07283.1 - 0.00053 20.0 3.0 0.0014 18.6 0.0 2.9 2 2 1 3 3 3 1 AAA ATPase domain AAA_19 PF13245.1 ESL07283.1 - 0.00059 19.5 0.2 0.0019 17.8 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 ESL07283.1 - 0.0029 16.3 0.0 0.0059 15.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 ESL07283.1 - 0.0044 16.4 1.6 0.051 12.9 0.2 2.4 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 ESL07283.1 - 0.005 16.7 2.8 0.0088 15.9 0.2 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ESL07283.1 - 0.015 14.3 0.0 0.035 13.1 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Peptidase_M50B PF13398.1 ESL07283.1 - 0.018 14.4 0.1 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like IstB_IS21 PF01695.12 ESL07283.1 - 0.022 14.1 0.1 0.048 13.0 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.21 ESL07283.1 - 0.026 13.9 0.0 0.1 12.0 0.0 2.1 1 1 1 2 2 2 0 Sigma-54 interaction domain THUMP PF02926.12 ESL07283.1 - 0.038 13.8 0.5 4.5 7.1 0.0 2.8 2 0 0 2 2 2 0 THUMP domain DUF2075 PF09848.4 ESL07283.1 - 0.042 12.8 0.0 0.072 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 ESL07283.1 - 0.079 12.0 0.1 0.24 10.4 0.1 1.8 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.1 ESL07283.1 - 0.08 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL07283.1 - 0.099 12.9 0.0 0.43 10.8 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.1 ESL07283.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain SpoU_methylase PF00588.14 ESL07285.1 - 1.1e-09 38.3 0.0 1.2e-06 28.4 0.0 3.5 3 1 0 3 3 3 2 SpoU rRNA Methylase family Mem_trans PF03547.13 ESL07287.1 - 2.1e-10 39.4 11.8 2.5e-10 39.2 8.2 1.0 1 0 0 1 1 1 1 Membrane transport protein DUF751 PF05421.6 ESL07287.1 - 0.013 15.8 1.4 0.013 15.8 1.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF751) DnaJ PF00226.26 ESL07288.1 - 9.3e-19 66.9 0.1 1.7e-18 66.0 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.27 ESL07289.1 - 2.1e-08 33.6 0.0 7.7e-07 28.7 0.0 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat Myosin_tail_1 PF01576.14 ESL07289.1 - 0.00033 18.5 7.1 0.00057 17.7 4.9 1.3 1 0 0 1 1 1 1 Myosin tail CorA PF01544.13 ESL07289.1 - 0.12 11.3 3.7 0.22 10.5 2.6 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein zf-CCCH PF00642.19 ESL07291.1 - 0.00095 18.7 15.6 0.093 12.4 1.6 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nucleoporin_C PF03177.9 ESL07292.1 - 0.073 11.5 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Non-repetitive/WGA-negative nucleoporin C-terminal NSP11 PF06471.7 ESL07292.1 - 0.1 10.8 0.0 0.14 10.2 0.0 1.1 1 0 0 1 1 1 0 NSP11 Lipase_3 PF01764.20 ESL07293.1 - 6.7e-05 22.5 0.3 0.00019 21.0 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) PGAP1 PF07819.8 ESL07293.1 - 0.011 15.3 0.1 0.022 14.3 0.1 1.5 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.2 ESL07293.1 - 0.033 13.9 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.7 ESL07293.1 - 0.075 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) CECR6_TMEM121 PF14997.1 ESL07298.1 - 0.00015 21.4 0.4 0.00015 21.4 0.2 2.9 3 0 0 3 3 3 2 CECR6/TMEM121 family Mito_carr PF00153.22 ESL07299.1 - 1.4e-56 188.1 6.3 2.3e-20 72.0 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Abi PF02517.11 ESL07300.1 - 6.5e-19 67.8 0.3 1.7e-18 66.5 0.2 1.7 1 0 0 1 1 1 1 CAAX protease self-immunity DUF4421 PF14391.1 ESL07300.1 - 0.16 11.1 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4421) Peptidase_S9 PF00326.16 ESL07301.1 - 9.2e-42 142.6 0.0 1.8e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.10 ESL07301.1 - 2.7e-35 121.7 0.0 7.8e-27 93.8 0.0 3.1 3 0 0 3 3 3 3 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S15 PF02129.13 ESL07301.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Cyclin_N PF00134.18 ESL07302.1 - 2.3e-38 130.6 0.1 4.4e-38 129.7 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESL07302.1 - 1.1e-30 105.9 0.2 2.7e-30 104.7 0.0 1.7 2 1 0 2 2 2 1 Cyclin, C-terminal domain FtsJ PF01728.14 ESL07303.1 - 6e-48 163.2 0.1 7.3e-48 162.9 0.1 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 ESL07303.1 - 8.8e-05 22.2 0.0 0.00016 21.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain NSP13 PF06460.7 ESL07303.1 - 0.076 11.8 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Coronavirus NSP13 Methyltransf_31 PF13847.1 ESL07303.1 - 0.078 12.5 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Abhydrolase_5 PF12695.2 ESL07304.1 - 1.1e-26 93.2 0.0 1.9e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL07304.1 - 1.7e-17 64.0 0.0 3.3e-17 63.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESL07304.1 - 6.7e-11 41.8 0.3 1.4e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Ank_2 PF12796.2 ESL07304.1 - 4.8e-09 36.4 0.3 3.1e-08 33.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL07304.1 - 2.1e-08 34.4 0.5 1.8e-07 31.4 0.1 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL07304.1 - 2.4e-06 27.6 1.1 0.00026 21.1 0.1 3.5 4 1 0 4 4 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL07304.1 - 1.1e-05 25.1 0.0 0.00016 21.5 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat AXE1 PF05448.7 ESL07304.1 - 1.2e-05 23.9 0.5 0.0062 15.0 0.2 2.9 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) Ank PF00023.25 ESL07304.1 - 3.1e-05 23.5 0.0 0.0002 21.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Peptidase_S15 PF02129.13 ESL07304.1 - 5e-05 22.8 0.0 0.072 12.5 0.0 2.2 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.3 ESL07304.1 - 0.00015 21.5 0.7 0.00064 19.5 0.1 2.2 2 0 0 2 2 2 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 ESL07304.1 - 0.0044 16.6 0.1 0.85 9.1 0.0 2.3 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ESL07304.1 - 0.01 15.2 0.2 0.037 13.4 0.1 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF829 PF05705.9 ESL07304.1 - 0.014 15.0 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) DcuC PF03606.10 ESL07304.1 - 0.024 12.9 0.0 0.044 12.0 0.0 1.3 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier BAAT_C PF08840.6 ESL07304.1 - 0.039 13.6 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydro_lipase PF04083.11 ESL07304.1 - 0.043 13.1 0.1 1.4 8.3 0.0 2.5 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Thymidylate_kin PF02223.12 ESL07304.1 - 0.12 11.7 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Thymidylate kinase UPF0113 PF03657.8 ESL07305.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0113) LSM PF01423.17 ESL07306.1 - 8.7e-15 54.0 0.2 1.1e-14 53.7 0.1 1.1 1 0 0 1 1 1 1 LSM domain Cullin PF00888.17 ESL07307.1 - 5.7e-18 64.7 0.0 1.1e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Cullin family FragX_IP PF05994.6 ESL07307.1 - 0.11 10.2 0.0 0.17 9.6 0.0 1.2 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family DUF788 PF05620.6 ESL07308.1 - 3e-34 118.3 0.0 3.5e-34 118.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) TMEM107 PF14995.1 ESL07308.1 - 0.091 12.8 2.1 1.4 9.0 0.0 2.2 1 1 1 2 2 2 0 Transmembrane protein Ribosomal_L17 PF01196.14 ESL07310.1 - 2.1e-13 50.6 0.0 3.2e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 DUF4061 PF13270.1 ESL07311.1 - 0.057 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) Flagellar_rod PF05149.7 ESL07312.1 - 7.4e-68 228.8 5.0 1.1e-67 228.3 3.5 1.2 1 0 0 1 1 1 1 Paraflagellar rod protein Sipho_Gp157 PF05565.6 ESL07312.1 - 0.0055 16.2 2.5 0.0055 16.2 1.8 1.7 1 1 1 2 2 2 1 Siphovirus Gp157 SpoIISA_toxin PF14171.1 ESL07312.1 - 0.015 14.5 1.2 0.028 13.6 0.8 1.3 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system DUF883 PF05957.8 ESL07312.1 - 0.066 13.6 8.9 1.3 9.5 0.2 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DDE_Tnp_1 PF01609.16 ESL07312.1 - 0.26 10.7 2.7 0.1 12.1 0.2 1.5 2 0 0 2 2 2 0 Transposase DDE domain ERp29 PF07749.7 ESL07312.1 - 0.71 10.5 6.0 3 8.5 1.0 2.6 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain ScpA_ScpB PF02616.9 ESL07312.1 - 1.3 8.5 13.5 0.065 12.7 4.0 1.9 1 1 1 2 2 2 0 ScpA/B protein DUF4200 PF13863.1 ESL07312.1 - 3 7.8 19.6 0.12 12.2 5.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF1043 PF06295.7 ESL07312.1 - 4.6 6.8 9.6 1.1 8.8 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Atg14 PF10186.4 ESL07312.1 - 7 5.4 12.3 0.19 10.6 1.9 2.0 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 ING PF12998.2 ESL07312.1 - 9.4 6.5 9.5 0.53 10.5 2.1 2.1 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding CPSF_A PF03178.10 ESL07313.1 - 1.6e-57 195.0 0.0 3e-57 194.1 0.0 1.5 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.4 ESL07313.1 - 0.0043 15.2 0.0 0.12 10.4 0.0 2.7 2 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term BBS2_C PF14782.1 ESL07313.1 - 0.093 11.2 0.1 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF3655 PF12379.3 ESL07313.1 - 0.097 12.6 1.3 0.22 11.4 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3655) WD40 PF00400.27 ESL07314.1 - 0.00064 19.5 0.1 5 7.1 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat PI3_PI4_kinase PF00454.22 ESL07315.1 - 5.6e-36 124.1 0.0 4.7e-34 117.9 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.1 ESL07315.1 - 0.057 12.4 0.0 0.086 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Thioredoxin_8 PF13905.1 ESL07318.1 - 1.1e-07 31.8 0.0 0.015 15.4 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin-like Carb_kinase PF01256.12 ESL07319.1 - 2.8e-51 174.1 3.1 4.5e-50 170.2 2.1 2.1 1 1 0 1 1 1 1 Carbohydrate kinase YjeF_N PF03853.10 ESL07319.1 - 8.8e-43 145.8 0.0 1.9e-42 144.7 0.0 1.6 1 0 0 1 1 1 1 YjeF-related protein N-terminus NAD_binding_10 PF13460.1 ESL07319.1 - 0.045 13.7 0.2 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 NADH(P)-binding NHR2 PF08788.6 ESL07319.1 - 0.091 12.2 0.1 17 4.9 0.0 2.6 3 0 0 3 3 3 0 NHR2 domain like tRNA-synt_2d PF01409.15 ESL07320.1 - 1.5e-81 273.2 0.3 2.1e-81 272.7 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 ESL07320.1 - 2.4e-06 26.5 0.4 4.5e-05 22.3 0.1 2.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) MarR PF01047.17 ESL07320.1 - 0.0022 17.6 0.0 0.0052 16.4 0.0 1.7 1 0 0 1 1 1 1 MarR family tRNA-synt_2b PF00587.20 ESL07320.1 - 0.0027 17.2 0.6 0.0027 17.2 0.4 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HTH_34 PF13601.1 ESL07320.1 - 0.0087 16.0 0.1 0.035 14.1 0.0 2.0 2 0 0 2 2 2 1 Winged helix DNA-binding domain RPA_C PF08784.6 ESL07320.1 - 0.015 15.7 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 Replication protein A C terminal MarR_2 PF12802.2 ESL07320.1 - 0.016 14.8 0.1 0.11 12.1 0.0 2.4 3 0 0 3 3 3 0 MarR family TrmB PF01978.14 ESL07320.1 - 0.02 14.5 0.0 0.062 13.0 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.7 ESL07320.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 HTH domain Phage_pRha PF09669.5 ESL07320.1 - 0.15 12.3 0.6 0.9 9.9 0.0 2.6 2 1 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Kinesin PF00225.18 ESL07321.1 - 4.6e-74 249.1 0.0 7.8e-74 248.3 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain SlyX PF04102.7 ESL07321.1 - 6.9 7.1 7.6 47 4.4 0.0 4.0 4 0 0 4 4 4 0 SlyX Ste5_C PF12194.3 ESL07322.1 - 0.017 14.7 0.0 0.8 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein kinase Fus3-binding RRM_6 PF14259.1 ESL07322.1 - 0.017 15.0 0.0 0.043 13.8 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Mre11_DNA_bind PF04152.9 ESL07323.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Mre11 DNA-binding presumed domain TPR_11 PF13414.1 ESL07324.1 - 1.9e-08 33.8 5.2 5.5e-05 22.7 1.2 2.5 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESL07324.1 - 3.4e-06 26.5 10.8 0.67 10.0 0.4 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESL07324.1 - 1e-05 25.3 1.4 0.47 10.7 0.0 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL07324.1 - 0.00014 21.7 14.3 0.01 15.7 2.3 4.3 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07324.1 - 0.00019 21.6 3.8 0.016 15.5 0.4 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07324.1 - 0.00033 21.2 5.4 0.0044 17.6 0.4 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07324.1 - 0.0014 18.1 5.0 7.2 6.4 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL07324.1 - 0.003 17.6 9.3 0.6 10.2 0.0 3.9 1 1 3 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESL07324.1 - 0.0074 16.6 1.1 21 5.8 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat B PF02216.11 ESL07324.1 - 0.015 15.0 0.2 0.22 11.3 0.1 2.3 2 0 0 2 2 2 0 B domain TPR_20 PF14561.1 ESL07324.1 - 0.077 13.1 0.6 1.6 8.8 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07324.1 - 0.081 13.6 13.3 5.1 8.0 0.1 5.4 4 2 3 7 7 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07324.1 - 0.25 11.2 11.6 0.32 10.8 0.0 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat PEPCK_ATP PF01293.15 ESL07325.1 - 3.5e-196 652.2 0.0 4.4e-196 651.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.1 ESL07325.1 - 0.03 14.2 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.1 ESL07325.1 - 0.034 14.0 0.0 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESL07325.1 - 0.12 11.9 0.1 0.3 10.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain GHMP_kinases_C PF08544.8 ESL07326.1 - 1.7e-18 66.6 0.3 3.7e-18 65.4 0.2 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESL07326.1 - 3.3e-15 55.9 2.6 7.2e-15 54.8 1.8 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain TPR_12 PF13424.1 ESL07327.1 - 5.8e-09 35.7 4.0 0.0052 16.6 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07327.1 - 7.2e-08 31.6 0.9 0.0025 17.4 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESL07327.1 - 1.6e-07 30.7 3.8 0.0013 18.5 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESL07327.1 - 1.7e-06 27.5 3.9 1.7e-05 24.3 0.2 3.0 2 1 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 ESL07327.1 - 1.9e-05 24.0 0.8 0.023 14.3 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07327.1 - 0.00042 20.8 3.3 0.005 17.4 0.5 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESL07327.1 - 0.00066 19.2 0.5 0.17 11.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07327.1 - 0.0016 18.7 0.3 0.0072 16.6 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07327.1 - 0.0019 18.6 2.1 0.57 10.9 0.1 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL07327.1 - 0.041 14.3 0.1 0.43 11.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESL07327.1 - 0.099 11.9 3.5 0.23 10.7 0.3 2.7 2 0 0 2 2 2 0 SHNi-TPR Voltage_CLC PF00654.15 ESL07330.1 - 5.6e-08 32.1 0.1 5.7e-05 22.3 0.0 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel FA_desaturase PF00487.19 ESL07330.1 - 0.047 13.1 1.1 0.073 12.5 0.7 1.3 1 0 0 1 1 1 0 Fatty acid desaturase Wzy_C PF04932.10 ESL07330.1 - 0.12 12.1 0.4 0.19 11.5 0.1 1.4 2 0 0 2 2 2 0 O-Antigen ligase DUF3094 PF11293.3 ESL07330.1 - 0.15 11.5 0.6 0.51 9.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) zf-U1 PF06220.7 ESL07332.1 - 1.2e-05 24.7 0.7 3.4e-05 23.3 0.5 1.8 1 0 0 1 1 1 1 U1 zinc finger NOA36 PF06524.7 ESL07332.1 - 0.036 13.3 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 NOA36 protein zf-C2H2_jaz PF12171.3 ESL07332.1 - 0.053 13.6 0.2 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding RasGEF_N PF00618.15 ESL07333.1 - 7.6e-11 42.0 0.0 1.7e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.14 ESL07333.1 - 2.2e-05 24.3 0.0 4.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain EMP24_GP25L PF01105.19 ESL07338.1 - 4.6e-25 88.3 0.0 6.3e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD 14-3-3 PF00244.15 ESL07339.1 - 0.00041 19.5 0.0 0.26 10.3 0.0 2.4 2 0 0 2 2 2 2 14-3-3 protein TAP42 PF04177.7 ESL07341.1 - 1.7e-32 112.7 3.9 2.2e-32 112.3 2.7 1.2 1 0 0 1 1 1 1 TAP42-like family DUF3584 PF12128.3 ESL07342.1 - 0.0052 14.1 38.1 0.0097 13.3 26.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) TLE_N PF03920.10 ESL07343.1 - 0.00097 18.9 0.2 0.0021 17.8 0.1 1.5 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain HALZ PF02183.13 ESL07343.1 - 0.0035 17.0 0.3 0.0035 17.0 0.2 1.8 2 0 0 2 2 2 1 Homeobox associated leucine zipper Rab5-bind PF09311.6 ESL07343.1 - 0.022 14.6 0.5 0.022 14.6 0.4 2.9 4 0 0 4 4 4 0 Rabaptin-like protein SlyX PF04102.7 ESL07343.1 - 2.1 8.8 9.9 0.55 10.6 0.3 2.9 3 0 0 3 3 3 0 SlyX FadA PF09403.5 ESL07343.1 - 2.4 8.1 6.7 9.3 6.2 0.5 3.1 3 0 0 3 3 3 0 Adhesion protein FadA Prefoldin_2 PF01920.15 ESL07343.1 - 4.2 7.1 9.0 0.67 9.7 0.3 2.7 3 0 0 3 3 3 0 Prefoldin subunit Vma12 PF11712.3 ESL07343.1 - 7.9 6.1 7.7 2.9e+02 1.1 5.3 2.3 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Viral_P18 PF04521.8 ESL07343.1 - 8.4 5.8 7.9 0.36 10.2 0.1 2.4 3 0 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein BTB_2 PF02214.17 ESL07344.1 - 4.1e-13 49.3 0.0 8.2e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Tyr_Deacylase PF02580.11 ESL07345.1 - 1.5e-40 138.5 0.0 1.7e-40 138.3 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase ECIST_Cterm PF14784.1 ESL07346.1 - 0.029 14.3 0.1 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 C-terminal domain of the ECSIT protein ProQ PF04352.8 ESL07346.1 - 0.062 12.9 0.2 0.37 10.4 0.0 2.3 3 0 0 3 3 3 0 ProQ/FINO family Serinc PF03348.10 ESL07346.1 - 0.087 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) ENTH PF01417.15 ESL07347.1 - 0.00015 21.5 0.0 0.033 14.0 0.0 2.3 2 0 0 2 2 2 2 ENTH domain DDE_Tnp_1_assoc PF13808.1 ESL07347.1 - 0.033 13.8 0.0 0.28 10.8 0.0 2.3 2 0 0 2 2 2 0 DDE_Tnp_1-associated ANTH PF07651.11 ESL07347.1 - 0.11 11.1 0.0 0.31 9.6 0.0 1.7 2 0 0 2 2 2 0 ANTH domain IF4E PF01652.13 ESL07348.1 - 4.1e-05 23.1 0.0 4.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E AFG1_ATPase PF03969.11 ESL07349.1 - 2.7e-55 187.6 0.0 1.5e-52 178.6 0.0 2.9 2 1 1 3 3 3 2 AFG1-like ATPase Sigma54_activ_2 PF14532.1 ESL07349.1 - 0.11 12.5 0.0 0.54 10.3 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain GST_C_2 PF13410.1 ESL07349.1 - 0.12 12.3 0.3 13 5.8 0.1 2.9 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain BCIP PF13862.1 ESL07350.1 - 6.5e-28 97.5 0.0 8.4e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DUF2076 PF09849.4 ESL07350.1 - 8.7 6.3 8.7 19 5.2 6.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) tRNA_m1G_MT PF01746.16 ESL07351.1 - 2e-24 86.2 0.0 3.4e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Atrophin-1 PF03154.10 ESL07351.1 - 2.5 6.1 6.5 3.1 5.8 4.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pep3_Vps18 PF05131.9 ESL07352.1 - 4.7e-14 52.0 0.4 4.2e-06 26.2 0.0 3.0 2 1 0 2 2 2 2 Pep3/Vps18/deep orange family Clathrin PF00637.15 ESL07352.1 - 4.4e-08 32.8 0.1 6.2e-07 29.1 0.0 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS PE-PPE PF08237.6 ESL07352.1 - 0.12 11.7 0.1 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Ribosomal_L14e PF01929.12 ESL07353.1 - 1.9e-24 85.8 5.1 1.9e-24 85.8 3.5 2.2 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.24 ESL07353.1 - 0.00012 21.6 2.3 0.00022 20.7 1.6 1.5 1 0 0 1 1 1 1 KOW motif NTF2 PF02136.15 ESL07354.1 - 7.6e-05 23.0 0.0 0.00013 22.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain IncA PF04156.9 ESL07355.1 - 0.00074 19.1 1.3 0.00074 19.1 0.9 2.1 3 0 0 3 3 3 1 IncA protein CCDC155 PF14662.1 ESL07355.1 - 0.0018 17.9 4.5 0.0018 17.9 3.1 1.8 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 ADIP PF11559.3 ESL07355.1 - 0.0027 17.6 5.1 0.0077 16.1 3.5 1.8 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Microtub_assoc PF07989.6 ESL07355.1 - 0.012 15.4 3.9 0.03 14.1 0.1 3.2 3 1 1 4 4 4 0 Microtubule associated Ly49 PF08391.5 ESL07355.1 - 0.13 12.3 4.7 0.21 11.6 0.4 2.8 3 1 0 3 3 3 0 Ly49-like protein, N-terminal region Tropomyosin_1 PF12718.2 ESL07355.1 - 0.64 9.8 7.9 1.8 8.3 2.8 2.7 3 0 0 3 3 3 0 Tropomyosin like bZIP_1 PF00170.16 ESL07355.1 - 0.82 9.6 6.8 1.9 8.5 0.7 3.7 3 1 1 4 4 4 0 bZIP transcription factor GAS PF13851.1 ESL07355.1 - 0.89 8.7 5.7 2.6 7.1 3.4 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIC PF04977.10 ESL07355.1 - 1.3 8.6 6.4 1.2 8.6 0.4 3.1 2 1 1 3 3 3 0 Septum formation initiator CENP-Q PF13094.1 ESL07355.1 - 1.6 8.7 7.4 8.6 6.3 4.1 2.3 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TMF_DNA_bd PF12329.3 ESL07355.1 - 2.2 8.1 6.9 1.3 8.8 0.1 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF972 PF06156.8 ESL07355.1 - 2.2 8.6 6.3 5 7.5 2.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF972) DUF4200 PF13863.1 ESL07355.1 - 9.7 6.1 10.0 28 4.6 6.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Ank_2 PF12796.2 ESL07356.1 - 1.3e-32 111.9 1.3 1.1e-09 38.4 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL07356.1 - 4e-30 103.6 0.2 2e-10 40.8 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 ESL07356.1 - 1.9e-25 87.3 0.8 4.1e-05 23.1 0.0 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 ESL07356.1 - 5.9e-21 72.4 1.7 0.00055 19.9 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.1 ESL07356.1 - 9e-18 63.9 0.8 0.00028 21.0 0.0 5.3 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Strep_his_triad PF04270.8 ESL07357.1 - 0.15 11.8 0.2 0.22 11.2 0.2 1.2 1 0 0 1 1 1 0 Streptococcal histidine triad protein Pribosyltran_N PF13793.1 ESL07358.1 - 5.5e-25 87.3 0.2 1.2e-22 79.8 0.0 2.6 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESL07358.1 - 6.6e-21 74.8 1.4 1.3e-19 70.6 0.1 2.5 3 0 0 3 3 3 1 Phosphoribosyl synthetase-associated domain SPX PF03105.14 ESL07358.1 - 9.8e-09 35.3 2.6 7.5e-05 22.6 0.1 2.3 1 1 1 2 2 2 2 SPX domain LRR_4 PF12799.2 ESL07359.1 - 2.6e-05 23.7 0.1 0.0014 18.2 0.0 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL07359.1 - 0.0002 21.0 0.1 0.00047 19.8 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.28 ESL07359.1 - 0.00067 19.3 2.2 0.076 13.0 0.1 3.1 3 0 0 3 3 3 2 Leucine Rich Repeat Herpes_BTRF1 PF04682.7 ESL07359.1 - 0.16 11.2 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region LRR_6 PF13516.1 ESL07360.1 - 0.0018 18.1 0.3 0.29 11.3 0.2 3.2 3 0 0 3 3 3 1 Leucine Rich repeat LRR_8 PF13855.1 ESL07360.1 - 0.0032 17.1 0.3 0.0032 17.1 0.2 1.8 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 ESL07360.1 - 0.17 11.5 1.0 9 6.0 0.0 3.2 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) MCD PF05292.6 ESL07361.1 - 9.9e-60 202.0 0.1 2.3e-36 125.2 0.0 3.0 2 1 0 2 2 2 2 Malonyl-CoA decarboxylase (MCD) Tetraspannin PF00335.15 ESL07362.1 - 1.2e-20 73.7 12.2 1.6e-20 73.3 8.4 1.1 1 0 0 1 1 1 1 Tetraspanin family UPF0104 PF03706.8 ESL07362.1 - 4.6 6.4 20.1 6.2 6.0 7.8 2.8 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0104) DUF1625 PF07787.7 ESL07362.1 - 5 6.2 5.6 11 5.2 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1625) Radial_spoke PF04712.7 ESL07363.1 - 1.4e-128 429.8 0.2 1.8e-128 429.3 0.2 1.0 1 0 0 1 1 1 1 Radial spokehead-like protein SIR2 PF02146.12 ESL07364.1 - 1.7e-45 154.9 0.0 2.1e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Glutaredoxin PF00462.19 ESL07365.1 - 1.1e-13 50.9 0.1 1.5e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Citrate_synt PF00285.16 ESL07366.1 - 4.3e-92 308.5 0.0 5e-92 308.3 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase Mannosyl_trans2 PF04188.8 ESL07367.1 - 2.4e-33 115.7 28.8 3.4e-26 92.1 15.3 2.2 2 0 0 2 2 2 2 Mannosyltransferase (PIG-V)) DSPc PF00782.15 ESL07368.1 - 7.6e-31 106.4 0.1 1.1e-30 105.9 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL07368.1 - 0.00017 21.0 0.0 0.0002 20.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESL07368.1 - 0.0012 18.9 0.1 0.0022 18.0 0.1 1.6 2 1 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.8 ESL07368.1 - 0.0043 16.4 0.1 0.0071 15.7 0.1 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family TFIIIC_sub6 PF10419.4 ESL07368.1 - 0.079 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 TFIIIC subunit AAA PF00004.24 ESL07369.1 - 3.5e-42 143.7 0.0 7.8e-42 142.5 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESL07369.1 - 1.2e-06 28.5 0.0 2.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL07369.1 - 6.7e-06 26.2 0.2 0.00068 19.7 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL07369.1 - 4.8e-05 23.4 0.0 0.00021 21.3 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESL07369.1 - 5.3e-05 22.9 0.2 0.00021 21.0 0.0 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 ESL07369.1 - 0.00031 19.7 0.0 0.00051 19.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESL07369.1 - 0.00053 19.0 0.0 0.00099 18.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESL07369.1 - 0.002 17.9 0.0 0.0041 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL07369.1 - 0.0033 18.2 0.1 0.0094 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL07369.1 - 0.0044 16.8 0.0 0.0086 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESL07369.1 - 0.0059 16.2 0.2 0.41 10.2 0.1 2.6 1 1 1 2 2 2 1 NACHT domain AAA_3 PF07726.6 ESL07369.1 - 0.0065 16.0 0.0 0.014 14.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ESL07369.1 - 0.0071 16.5 0.0 0.017 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 ESL07369.1 - 0.0089 15.7 0.6 0.018 14.7 0.4 1.4 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 ESL07369.1 - 0.011 15.1 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 ESL07369.1 - 0.015 15.6 0.0 0.034 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 ESL07369.1 - 0.016 14.0 0.0 0.059 12.2 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_28 PF13521.1 ESL07369.1 - 0.024 14.5 0.3 0.069 13.1 0.1 1.9 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.4 ESL07369.1 - 0.038 12.9 0.6 0.16 10.9 0.2 2.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 ESL07369.1 - 0.038 13.1 0.3 0.49 9.4 0.1 2.2 1 1 1 2 2 2 0 KaiC Zeta_toxin PF06414.7 ESL07369.1 - 0.042 12.9 0.0 0.072 12.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 ESL07369.1 - 0.044 13.1 0.6 1.9 7.8 0.2 2.3 1 1 1 2 2 2 0 AAA domain TIP49 PF06068.8 ESL07369.1 - 0.05 12.3 0.0 0.095 11.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.16 ESL07369.1 - 0.09 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhyH PF05721.8 ESL07370.1 - 0.0074 16.3 0.1 4 7.4 0.1 2.8 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) ERp29 PF07749.7 ESL07370.1 - 0.15 12.7 0.8 0.26 11.9 0.5 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF2207 PF09972.4 ESL07371.1 - 0.069 11.7 0.0 0.098 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3377 PF11857.3 ESL07371.1 - 0.085 12.4 0.5 0.17 11.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.1 ESL07371.1 - 0.18 11.4 1.5 0.84 9.3 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family Fumble PF03630.9 ESL07373.1 - 4.4e-70 236.2 0.0 6.8e-70 235.5 0.0 1.2 1 0 0 1 1 1 1 Fumble AMP-binding PF00501.23 ESL07373.1 - 1.6e-18 66.3 0.3 2.6e-18 65.6 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Exo_endo_phos PF03372.18 ESL07373.1 - 1.9e-10 41.1 0.1 4.7e-10 39.8 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family CSD PF00313.17 ESL07374.1 - 6e-12 45.1 1.1 2.2e-07 30.5 0.4 4.1 4 0 0 4 4 4 2 'Cold-shock' DNA-binding domain S1-like PF14444.1 ESL07374.1 - 0.057 13.1 0.2 0.2 11.4 0.1 2.0 1 0 0 1 1 1 0 S1-like HN PF00423.14 ESL07374.1 - 0.26 9.5 0.0 0.35 9.0 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase TPR_11 PF13414.1 ESL07375.1 - 1.6e-29 101.3 13.9 1e-12 47.4 0.5 5.0 2 2 3 5 5 5 5 TPR repeat TPR_16 PF13432.1 ESL07375.1 - 1.7e-21 76.3 16.0 1.3e-07 32.0 0.1 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESL07375.1 - 3.9e-19 66.9 11.5 1.3e-05 24.7 0.1 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESL07375.1 - 9.6e-19 65.9 9.4 4.1e-05 23.4 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07375.1 - 1.7e-16 59.0 9.5 2.1e-07 30.2 0.1 6.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07375.1 - 3.7e-14 51.9 17.2 0.0069 16.9 0.1 7.3 4 1 3 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07375.1 - 9.2e-12 45.1 12.5 0.00069 19.9 0.2 4.8 2 2 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL07375.1 - 3e-11 43.0 0.5 1.5e-05 24.8 0.0 3.9 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL07375.1 - 1.5e-08 33.8 2.4 0.025 14.3 0.0 5.7 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESL07375.1 - 1.6e-05 24.6 9.8 0.013 15.3 0.2 4.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07375.1 - 6.3e-05 22.4 1.3 2 8.4 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESL07375.1 - 0.0012 18.9 6.1 6.5 6.9 0.7 4.4 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL07375.1 - 0.0014 18.9 5.3 9.5 6.9 0.0 5.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Nbs1_C PF08599.5 ESL07375.1 - 0.025 14.4 0.2 0.078 12.9 0.1 1.9 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 Glyco_hyd_65N_2 PF14498.1 ESL07375.1 - 0.026 14.1 1.0 7.3 6.2 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, N-terminal domain TPR_10 PF13374.1 ESL07375.1 - 0.063 13.2 3.1 2.9 7.9 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat NDUF_B5 PF09781.4 ESL07376.1 - 0.035 13.3 0.6 0.058 12.6 0.4 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit Pyrid_oxidase_2 PF13883.1 ESL07376.1 - 0.037 13.7 0.1 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Peptidase_S6 PF02395.11 ESL07376.1 - 0.12 10.4 0.0 0.15 10.1 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin A1 protease Chromo PF00385.19 ESL07377.1 - 0.081 12.6 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Pkinase PF00069.20 ESL07378.1 - 2.9e-63 213.4 0.0 3.5e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07378.1 - 1.5e-41 142.2 0.0 1.8e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07378.1 - 0.00012 21.1 0.0 0.00034 19.6 0.0 1.7 1 1 0 1 1 1 1 Kinase-like YjcZ PF13990.1 ESL07378.1 - 0.058 12.5 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 YjcZ-like protein Choline_kinase PF01633.15 ESL07378.1 - 0.071 12.6 0.1 3.4 7.1 0.1 2.2 1 1 1 2 2 2 0 Choline/ethanolamine kinase APH PF01636.18 ESL07378.1 - 0.086 12.5 0.0 0.19 11.4 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family COG7 PF10191.4 ESL07379.1 - 2.8e-23 81.7 13.9 3.5e-18 64.9 8.2 2.2 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) PilJ PF13675.1 ESL07379.1 - 0.0082 16.4 10.8 6.2 7.1 0.1 5.1 3 2 2 5 5 5 1 Type IV pili methyl-accepting chemotaxis transducer N-term Mis12 PF05859.7 ESL07379.1 - 0.017 14.9 0.5 0.062 13.1 0.3 2.0 1 0 0 1 1 1 0 Mis12 protein G6PD_C PF02781.11 ESL07379.1 - 0.064 12.1 0.5 0.1 11.4 0.4 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, C-terminal domain Baculo_PEP_C PF04513.7 ESL07379.1 - 0.11 12.2 8.3 4 7.2 0.7 3.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran_2 PF12848.2 ESL07379.1 - 2.5 8.0 5.1 2.1 8.2 0.4 2.9 1 1 2 3 3 3 0 ABC transporter FAD_binding_2 PF00890.19 ESL07380.1 - 4e-32 111.5 0.0 5.6e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 ESL07380.1 - 2.3e-09 37.7 0.0 4.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL07380.1 - 0.00091 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Pkinase PF00069.20 ESL07381.1 - 6.2e-34 117.3 0.0 8.4e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07381.1 - 8.6e-15 54.5 0.0 1.1e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL07381.1 - 1e-05 25.4 0.1 0.0013 18.5 0.0 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL07381.1 - 0.029 13.4 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL07381.1 - 0.11 11.3 0.0 0.43 9.4 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Ufm1 PF03671.9 ESL07382.1 - 1.9e-28 98.0 0.1 2.2e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Kinesin PF00225.18 ESL07383.1 - 2e-91 306.2 0.0 3.3e-91 305.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3883 PF13020.1 ESL07384.1 - 9.6e-18 63.7 0.0 2e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) DUF463 PF04317.7 ESL07384.1 - 0.084 11.4 0.0 0.15 10.5 0.0 1.4 1 0 0 1 1 1 0 YcjX-like family, DUF463 Cluap1 PF10234.4 ESL07385.1 - 1.2e-101 339.4 10.3 1.5e-101 339.0 7.2 1.1 1 0 0 1 1 1 1 Clusterin-associated protein-1 SseC PF04888.7 ESL07385.1 - 0.078 12.2 6.9 0.13 11.5 4.8 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family SPT16 PF08644.6 ESL07385.1 - 0.19 11.5 7.1 0.085 12.6 0.8 2.2 1 1 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) NPV_P10 PF05531.7 ESL07385.1 - 2.1 8.6 6.3 0.32 11.2 0.9 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Cortex-I_coil PF09304.5 ESL07385.1 - 2.4 8.2 12.0 0.23 11.5 2.8 2.6 2 1 0 2 2 2 0 Cortexillin I, coiled coil COG2 PF06148.6 ESL07385.1 - 2.4 8.0 8.5 0.89 9.4 2.0 2.7 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.9 ESL07385.1 - 2.7 7.5 18.6 8.6 5.8 12.8 1.9 1 1 0 1 1 1 0 IncA protein LSM PF01423.17 ESL07386.1 - 0.057 12.9 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 LSM domain Ion_trans_2 PF07885.11 ESL07387.1 - 0.0027 17.3 0.5 0.024 14.3 0.1 2.8 2 1 0 2 2 2 1 Ion channel Methyltransf_23 PF13489.1 ESL07388.1 - 2.5e-14 53.3 0.1 2.6e-13 50.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL07388.1 - 1.4e-13 51.0 0.2 7.9e-13 48.7 0.0 2.3 2 1 1 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESL07388.1 - 3.6e-10 39.3 0.0 5.9e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESL07388.1 - 7.5e-07 29.5 0.0 0.00035 20.9 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.1 ESL07388.1 - 7e-05 22.4 0.0 0.00017 21.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL07388.1 - 0.00064 20.0 0.0 0.0048 17.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain RRM_5 PF13893.1 ESL07389.1 - 0.00047 19.9 0.5 0.0011 18.7 0.3 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) S10_plectin PF03501.10 ESL07390.1 - 1.6e-33 114.4 0.0 1.9e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 Plectin/S10 domain API5 PF05918.6 ESL07390.1 - 7.2 4.9 14.9 9.7 4.5 10.3 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DnaJ PF00226.26 ESL07391.1 - 2.4e-09 36.8 0.1 5.5e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DDE_Tnp_ISL3 PF01610.12 ESL07391.1 - 0.0024 17.4 0.3 0.0035 16.9 0.2 1.2 1 0 0 1 1 1 1 Transposase YrzO PF14142.1 ESL07391.1 - 0.11 12.1 2.5 0.21 11.2 0.0 2.5 2 1 0 2 2 2 0 YrzO-like protein UreE_N PF02814.10 ESL07391.1 - 0.38 10.2 3.5 1.6 8.2 0.1 2.5 2 0 0 2 2 2 0 UreE urease accessory protein, N-terminal domain Ion_trans_2 PF07885.11 ESL07392.1 - 7.3e-06 25.6 3.0 7.3e-06 25.6 2.1 2.3 2 1 0 2 2 2 1 Ion channel Cep57_CLD PF14073.1 ESL07392.1 - 0.0055 16.5 0.3 0.0085 15.9 0.2 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 Lig_chan PF00060.21 ESL07392.1 - 1.3 8.7 4.7 0.58 9.8 1.2 2.0 2 0 0 2 2 2 0 Ligand-gated ion channel Histone PF00125.19 ESL07394.1 - 1.7e-23 82.5 1.5 1.9e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL07394.1 - 7.1e-06 25.9 0.7 9.9e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESL07394.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated CENP-S PF15630.1 ESL07394.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore component CENP-S YihI PF04220.7 ESL07394.1 - 0.52 9.6 2.3 0.69 9.2 1.6 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) HMGL-like PF00682.14 ESL07396.1 - 7.1e-07 29.1 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 HMGL-like EF-hand_7 PF13499.1 ESL07396.1 - 1.2e-05 25.3 0.1 1.9e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL07396.1 - 0.0006 18.9 0.1 0.016 14.4 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 ESL07396.1 - 0.00094 18.8 0.2 0.029 14.2 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 ESL07396.1 - 0.0031 17.0 0.5 0.19 11.3 0.3 2.6 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_4 PF12763.2 ESL07396.1 - 0.06 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Ten_N PF06484.7 ESL07397.1 - 0.019 14.1 0.1 0.033 13.3 0.1 1.3 1 0 0 1 1 1 0 Teneurin Intracellular Region Radical_SAM PF04055.16 ESL07398.1 - 0.032 14.3 0.3 13 5.9 0.0 4.4 4 0 0 4 4 4 0 Radical SAM superfamily zf-CCHC_4 PF14392.1 ESL07398.1 - 0.2 11.3 20.3 0.065 12.9 0.3 4.0 4 0 0 4 4 4 0 Zinc knuckle WD40 PF00400.27 ESL07400.1 - 2.5e-07 30.3 2.2 0.33 10.8 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESL07400.1 - 0.06 12.8 0.1 39 3.8 0.0 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain tRNA-synt_2 PF00152.15 ESL07401.1 - 4.4e-68 229.5 0.0 6e-68 229.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_synt_1c_R1 PF04558.10 ESL07401.1 - 6.4e-38 129.8 0.0 1e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_anti-codon PF01336.20 ESL07401.1 - 5.2e-11 42.2 0.0 1e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PPR PF01535.15 ESL07402.1 - 0.032 14.1 0.2 2 8.5 0.0 3.7 4 0 0 4 4 4 0 PPR repeat TPR_12 PF13424.1 ESL07402.1 - 0.067 13.1 0.4 1.8 8.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR_3 PF13812.1 ESL07402.1 - 0.17 12.2 8.5 3.1 8.3 0.0 4.6 6 0 0 6 6 6 0 Pentatricopeptide repeat domain WD40 PF00400.27 ESL07403.1 - 0.063 13.1 0.1 0.42 10.5 0.1 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat MIF4G PF02854.14 ESL07404.1 - 1.6e-08 34.2 0.0 2.2e-07 30.5 0.0 2.5 2 0 0 2 2 2 1 MIF4G domain PPP4R2 PF09184.6 ESL07404.1 - 2 7.8 21.1 4.1 6.8 14.6 1.4 1 0 0 1 1 1 0 PPP4R2 Ycf1 PF05758.7 ESL07404.1 - 3.5 5.2 2.7 5.3 4.6 1.9 1.2 1 0 0 1 1 1 0 Ycf1 FAD_binding_1 PF00667.15 ESL07405.1 - 7.1e-37 126.9 0.0 9.4e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 ESL07405.1 - 5.9e-14 52.5 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.20 ESL07405.1 - 5.3e-11 42.6 0.1 1.3e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Flavodoxin NAD_binding_3 PF03447.11 ESL07407.1 - 0.11 12.8 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GCD14 PF08704.5 ESL07408.1 - 5.2e-39 134.2 0.0 6.7e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 ESL07408.1 - 0.00016 21.2 0.0 0.00023 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESL07408.1 - 0.0013 18.3 0.0 0.0017 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 ESL07408.1 - 0.0047 16.9 0.2 0.01 15.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Nuc_sug_transp PF04142.10 ESL07409.1 - 2.4e-46 157.8 10.8 5.1e-46 156.7 7.5 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter EmrE PF13536.1 ESL07409.1 - 3.9e-05 23.8 5.4 3.9e-05 23.8 3.7 3.1 4 1 0 4 4 4 1 Multidrug resistance efflux transporter TPT PF03151.11 ESL07409.1 - 0.00095 18.8 2.8 0.00095 18.8 2.0 3.2 3 1 0 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 ESL07409.1 - 0.0012 18.8 3.5 0.0012 18.8 2.4 3.7 4 0 0 4 4 4 1 EamA-like transporter family NADH-u_ox-rdase PF10785.4 ESL07409.1 - 5.9 7.2 9.1 0.37 11.0 0.5 2.9 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit PIF1 PF05970.9 ESL07410.1 - 7.7e-21 74.4 0.7 1.5e-12 47.1 0.0 2.7 3 0 0 3 3 3 2 PIF1-like helicase Herpes_Helicase PF02689.9 ESL07410.1 - 2.9e-08 31.9 0.0 5e-08 31.1 0.0 1.3 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESL07410.1 - 5.9e-05 23.1 0.0 0.00025 21.1 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain PIN_4 PF13638.1 ESL07410.1 - 0.064 13.3 0.0 0.24 11.5 0.0 2.0 1 1 0 1 1 1 0 PIN domain AAA_11 PF13086.1 ESL07410.1 - 0.26 10.8 1.9 0.24 10.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain PRMT5 PF05185.11 ESL07411.1 - 6.2e-70 236.3 0.0 8.5e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase tRNA-synt_2 PF00152.15 ESL07412.1 - 4.9e-89 298.4 0.1 6.4e-89 298.0 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESL07412.1 - 2.3e-12 46.5 0.0 4.4e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESL07412.1 - 5.7e-08 32.2 0.0 0.00041 19.6 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ESL07412.1 - 0.0034 17.0 0.1 0.97 8.9 0.0 3.1 3 0 0 3 3 3 1 tRNA synthetase class II core domain (G, H, P, S and T) ALF PF03752.8 ESL07412.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Short repeats of unknown function PP2C PF00481.16 ESL07414.1 - 1.3e-50 172.2 0.0 1.4e-50 172.0 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL07414.1 - 3.6e-05 23.2 0.0 8.9e-05 21.9 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C META PF03724.11 ESL07415.1 - 3.6e-10 39.5 0.0 4.5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 META domain Reo_sigmaC PF04582.7 ESL07417.1 - 2.4 7.2 21.2 2.1 7.4 1.7 3.6 2 2 2 4 4 4 0 Reovirus sigma C capsid protein Activator_LAG-3 PF11498.3 ESL07418.1 - 0.1 11.2 0.6 0.2 10.3 0.1 1.7 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Spt4 PF06093.8 ESL07420.1 - 6.2e-13 48.4 0.1 1.1e-12 47.6 0.0 1.5 1 1 0 1 1 1 1 Spt4/RpoE2 zinc finger CobT PF06213.7 ESL07420.1 - 0.0053 15.9 2.2 0.0065 15.6 1.5 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Nucleoplasmin PF03066.10 ESL07420.1 - 0.028 13.9 2.7 0.039 13.4 1.8 1.2 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 ESL07420.1 - 0.12 11.9 1.3 0.14 11.7 0.9 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2072 PF09845.4 ESL07420.1 - 0.13 12.1 0.6 0.82 9.6 0.1 1.9 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) NOA36 PF06524.7 ESL07420.1 - 7.4 5.7 6.8 11 5.1 4.7 1.2 1 0 0 1 1 1 0 NOA36 protein CAP_N PF01213.14 ESL07421.1 - 2.3 7.4 7.2 0.13 11.5 0.4 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal SET PF00856.23 ESL07422.1 - 0.00086 19.6 0.0 0.0019 18.5 0.0 1.5 1 0 0 1 1 1 1 SET domain Methyltransf_23 PF13489.1 ESL07424.1 - 0.0021 17.7 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RRM_6 PF14259.1 ESL07425.1 - 0.00087 19.2 0.0 0.062 13.2 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL07425.1 - 0.0017 17.9 0.0 0.13 11.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CH PF00307.26 ESL07427.1 - 8.1e-09 35.5 0.1 0.0027 17.7 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain TRAPP PF04051.11 ESL07429.1 - 3.6e-26 91.5 0.0 4.4e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ribonuc_red_sm PF00268.16 ESL07430.1 - 1e-113 379.0 0.2 1.2e-113 378.8 0.1 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Transposase_20 PF02371.11 ESL07433.1 - 0.12 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family RIC3 PF15361.1 ESL07434.1 - 7.1 6.8 6.0 4.1 7.6 0.2 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 UDG PF03167.14 ESL07435.1 - 2.8e-20 72.3 0.1 3.7e-20 71.9 0.1 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily ADK PF00406.17 ESL07436.1 - 1.1e-39 135.7 0.0 1.4e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 ESL07436.1 - 4.1e-07 30.3 0.0 1.3e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESL07436.1 - 2.8e-06 28.1 0.0 1.1e-05 26.2 0.0 1.8 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.9 ESL07436.1 - 0.00034 20.2 0.0 0.00081 19.0 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Zeta_toxin PF06414.7 ESL07436.1 - 0.0013 17.8 0.1 0.011 14.8 0.1 2.3 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 ESL07436.1 - 0.0033 17.3 0.0 0.012 15.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL07436.1 - 0.0095 14.6 0.0 2.9 6.5 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA PF00004.24 ESL07436.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DREV PF05219.7 ESL07437.1 - 5e-60 202.6 0.0 6e-60 202.3 0.0 1.0 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.1 ESL07437.1 - 1.9e-09 37.4 0.0 8.4e-09 35.3 0.0 2.0 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL07437.1 - 3.4e-07 30.6 0.0 2.9e-06 27.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL07437.1 - 0.00023 21.6 0.3 0.0055 17.2 0.2 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL07437.1 - 0.0018 18.6 0.0 0.005 17.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL07437.1 - 0.031 13.8 0.0 0.66 9.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Kinesin PF00225.18 ESL07438.1 - 8.5e-84 281.1 0.0 9.6e-83 277.6 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain AAA_22 PF13401.1 ESL07438.1 - 0.15 12.1 2.4 0.33 11.0 0.0 2.7 3 1 1 4 4 4 0 AAA domain HNF-1_N PF04814.8 ESL07438.1 - 0.38 10.8 10.0 0.88 9.6 6.9 1.6 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF87 PF01935.12 ESL07438.1 - 0.93 9.2 6.8 0.97 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 DUF342 PF03961.8 ESL07438.1 - 1.5 7.1 10.5 2.7 6.3 7.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PH_11 PF15413.1 ESL07439.1 - 8.8e-05 22.7 0.0 0.00028 21.0 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESL07439.1 - 0.025 14.7 0.0 0.069 13.3 0.0 1.8 1 0 0 1 1 1 0 PH domain TPR_2 PF07719.12 ESL07440.1 - 8.6e-05 22.1 6.5 0.2 11.6 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07440.1 - 0.0017 18.8 22.9 0.039 14.5 1.0 5.7 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL07440.1 - 0.083 12.8 7.6 9.4 6.2 0.3 4.0 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07440.1 - 0.13 11.9 1.7 30 4.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07440.1 - 0.46 11.2 22.7 0.33 11.6 1.9 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESL07440.1 - 1.4 8.8 8.8 1.7 8.5 0.5 4.0 3 2 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESL07440.1 - 1.6 8.4 10.3 1.8 8.2 0.1 3.7 4 2 2 6 6 6 0 TPR repeat TPR_19 PF14559.1 ESL07440.1 - 8.6 6.7 14.5 0.27 11.6 1.3 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat Nol1_Nop2_Fmu PF01189.12 ESL07441.1 - 1e-21 77.5 0.0 8.3e-21 74.5 0.0 2.3 3 0 0 3 3 3 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 ESL07441.1 - 0.045 13.7 0.0 0.19 11.7 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 ESL07441.1 - 0.092 12.7 0.0 0.25 11.2 0.0 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase BTB_2 PF02214.17 ESL07442.1 - 4e-09 36.5 0.0 1.5e-08 34.7 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Phage_rep_org_N PF09681.5 ESL07442.1 - 0.05 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) RRM_1 PF00076.17 ESL07443.1 - 5.8e-15 54.6 0.0 1.1e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.16 ESL07443.1 - 9.5e-11 42.1 0.0 3.7e-10 40.2 0.0 2.0 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_6 PF14259.1 ESL07443.1 - 5.8e-10 39.0 0.1 1.6e-09 37.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07443.1 - 4.6e-08 32.8 0.2 1.1e-07 31.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BLYB PF05289.6 ESL07445.1 - 0.011 15.4 0.0 0.053 13.3 0.0 2.0 2 0 0 2 2 2 0 Borrelia hemolysin accessory protein Peptidase_C65 PF10275.4 ESL07446.1 - 1.7e-60 204.3 0.0 1.9e-60 204.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.14 ESL07446.1 - 5.3e-08 33.4 0.1 1.6e-05 25.4 0.1 2.2 1 1 0 1 1 1 1 OTU-like cysteine protease UCH PF00443.24 ESL07447.1 - 3.1e-54 183.8 0.3 3.1e-54 183.8 0.2 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL07447.1 - 1.1e-22 80.8 1.5 1.6e-22 80.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase NMD3 PF04981.8 ESL07447.1 - 0.063 12.3 0.0 0.063 12.3 0.0 2.1 2 0 0 2 2 2 0 NMD3 family Sgf11 PF08209.6 ESL07447.1 - 0.24 10.7 0.1 0.24 10.7 0.0 2.2 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) DivIVA PF05103.8 ESL07447.1 - 0.29 11.1 0.1 0.29 11.1 0.1 2.3 2 0 0 2 2 2 0 DivIVA protein zf-C3HC4_3 PF13920.1 ESL07447.1 - 7.4 6.3 6.9 16 5.2 0.8 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) GHMP_kinases_N PF00288.21 ESL07448.1 - 0.69 10.0 4.6 1.7 8.7 3.2 1.7 1 0 0 1 1 1 0 GHMP kinases N terminal domain Kinesin PF00225.18 ESL07449.1 - 2.9e-57 193.8 0.1 1.1e-55 188.7 0.1 2.7 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESL07449.1 - 0.034 13.0 0.3 0.14 11.0 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF4559 PF15112.1 ESL07449.1 - 0.06 12.5 2.2 0.11 11.6 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) AAA_22 PF13401.1 ESL07449.1 - 0.064 13.3 0.6 0.71 10.0 0.1 2.8 2 0 0 2 2 2 0 AAA domain RRM_1 PF00076.17 ESL07450.1 - 1.6e-12 46.8 0.0 2.3e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL07450.1 - 5.8e-10 39.0 0.0 8.7e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07450.1 - 1.5e-05 24.7 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3807 PF12720.2 ESL07451.1 - 5.7 7.0 14.6 0.71 10.0 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) NAD-GH PF10712.4 ESL07453.1 - 3.7e-14 51.9 4.8 4.4e-14 51.6 3.4 1.1 1 0 0 1 1 1 1 NAD-specific glutamate dehydrogenase FAD_binding_2 PF00890.19 ESL07454.1 - 6.9e-114 380.9 1.0 9.9e-114 380.4 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 ESL07454.1 - 3.4e-43 146.5 1.0 5e-43 146.0 0.7 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term DAO PF01266.19 ESL07454.1 - 2.3e-05 23.4 0.4 0.021 13.7 0.1 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESL07454.1 - 2.6e-05 24.1 0.0 0.01 15.7 0.1 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESL07454.1 - 0.00013 21.1 0.1 0.038 13.0 0.1 2.9 3 0 0 3 3 3 1 Thi4 family GIDA PF01134.17 ESL07454.1 - 0.0025 16.7 2.5 0.1 11.4 1.7 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.9 ESL07454.1 - 0.016 13.6 0.2 0.032 12.6 0.1 1.5 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.7 ESL07454.1 - 0.028 13.3 2.2 1 8.2 0.4 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Epimerase PF01370.16 ESL07455.1 - 2e-66 223.8 0.0 2.5e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL07455.1 - 1.8e-06 27.0 0.0 2.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESL07455.1 - 0.0072 15.2 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein zf-UBP PF02148.14 ESL07455.1 - 0.049 13.7 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein NAD_binding_10 PF13460.1 ESL07455.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding adh_short PF00106.20 ESL07457.1 - 1e-23 84.0 4.1 5.4e-23 81.7 2.9 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL07457.1 - 3e-11 43.3 0.6 4.6e-11 42.7 0.4 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESL07457.1 - 4e-09 36.6 0.1 6.4e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ESL07457.1 - 1.5e-07 31.1 0.2 2e-07 30.7 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESL07457.1 - 7.2e-05 22.8 0.1 0.00013 21.9 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESL07457.1 - 0.069 12.3 1.7 0.16 11.1 0.2 1.9 2 0 0 2 2 2 0 NmrA-like family NAP PF00956.13 ESL07458.1 - 3e-74 249.2 7.7 3e-74 249.2 5.4 3.2 3 1 0 3 3 3 1 Nucleosome assembly protein (NAP) Spt5_N PF11942.3 ESL07458.1 - 0.0041 17.6 4.7 0.0041 17.6 3.3 5.9 5 1 1 6 6 6 1 Spt5 transcription elongation factor, acidic N-terminal Herpes_UL36 PF03586.8 ESL07458.1 - 0.01 14.9 0.8 0.017 14.2 0.6 1.3 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein Ctf8 PF09696.5 ESL07458.1 - 4.5 7.0 13.4 1.1 9.1 3.1 3.2 3 1 1 4 4 4 0 Ctf8 ACC_epsilon PF13822.1 ESL07458.1 - 8.7 6.7 9.4 0.45 10.8 2.2 2.2 2 1 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit MOZ_SAS PF01853.13 ESL07459.1 - 1.6e-44 151.3 0.0 2.1e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_1 PF00583.19 ESL07459.1 - 0.00011 22.1 0.0 0.00027 20.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL07459.1 - 0.071 13.2 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4339 PF14237.1 ESL07461.1 - 7.9e-12 44.5 0.5 1.6e-11 43.5 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) CDC14 PF08045.6 ESL07461.1 - 0.0064 15.6 3.8 0.19 10.8 0.1 2.5 2 0 0 2 2 2 2 Cell division control protein 14, SIN component Arm PF00514.18 ESL07461.1 - 0.008 15.9 2.7 0.082 12.7 0.0 3.3 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat TBCC PF07986.7 ESL07463.1 - 1.2e-34 118.2 3.9 2.1e-34 117.4 2.7 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Band_7 PF01145.20 ESL07464.1 - 2.5e-23 82.8 0.7 3.7e-23 82.3 0.5 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family HIGH_NTase1 PF05636.6 ESL07464.1 - 0.063 12.3 0.5 0.08 11.9 0.3 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase Topoisom_bac PF01131.15 ESL07465.1 - 1.8e-95 320.1 0.0 2.2e-95 319.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 ESL07465.1 - 5.6e-12 45.5 0.0 1.1e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Toprim domain zf-GRF PF06839.7 ESL07465.1 - 1.4e-07 31.3 0.5 1.4e-07 31.3 0.3 2.5 2 0 0 2 2 2 1 GRF zinc finger zf-C4_Topoisom PF01396.14 ESL07465.1 - 3.2e-05 23.3 2.0 3.2e-05 23.3 1.4 3.3 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger Cullin_Nedd8 PF10557.4 ESL07465.1 - 0.25 11.1 0.0 7.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Cullin protein neddylation domain PRP38 PF03371.10 ESL07466.1 - 2.3e-16 59.9 0.0 2.8e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Phytochelatin PF05023.9 ESL07467.1 - 1.7e-08 33.6 0.0 0.0017 17.3 0.0 4.0 4 0 0 4 4 4 2 Phytochelatin synthase zf-C3HC4_2 PF13923.1 ESL07469.1 - 3.9e-09 36.3 9.7 9.5e-09 35.1 6.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL07469.1 - 1.2e-06 28.2 9.2 4.3e-06 26.4 6.4 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESL07469.1 - 2.4e-06 27.1 8.2 2.4e-06 27.1 5.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL07469.1 - 6.7e-05 22.5 8.4 0.00019 21.1 5.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESL07469.1 - 0.0002 21.1 9.5 0.0002 21.1 6.6 2.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 ESL07469.1 - 0.0018 17.9 7.0 0.0045 16.6 4.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 ESL07469.1 - 0.0022 17.6 7.1 0.0052 16.4 4.9 1.7 1 0 0 1 1 1 1 PHD-finger zf-RING_UBOX PF13445.1 ESL07469.1 - 0.0041 16.7 3.6 0.013 15.2 2.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESL07469.1 - 0.0089 15.7 3.0 0.029 14.1 2.1 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-MIZ PF02891.15 ESL07469.1 - 0.01 15.3 5.6 0.03 13.8 3.9 1.8 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Nse PF11789.3 ESL07469.1 - 0.017 14.6 1.8 0.041 13.4 1.3 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit HIT PF01230.18 ESL07469.1 - 0.1 13.1 0.3 0.1 13.1 0.2 3.8 3 1 1 4 4 4 0 HIT domain FlaC_arch PF05377.6 ESL07469.1 - 3.5 7.6 9.4 28 4.7 0.1 5.4 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) Totivirus_coat PF05518.6 ESL07470.1 - 0.23 9.2 2.3 0.27 8.9 1.6 1.1 1 0 0 1 1 1 0 Totivirus coat protein Peptidase_C48 PF02902.14 ESL07471.1 - 4.2e-14 52.6 0.2 3.1e-13 49.8 0.1 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Nudc_N PF14050.1 ESL07473.1 - 4.2e-18 65.0 0.1 9e-18 63.9 0.1 1.6 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.11 ESL07473.1 - 8.9e-16 58.2 0.0 1.5e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 CS domain Bindin PF02084.10 ESL07473.1 - 0.38 10.7 4.8 0.62 10.0 3.3 1.3 1 0 0 1 1 1 0 Bindin Vfa1 PF08432.5 ESL07473.1 - 1.3 9.0 9.9 0.78 9.7 3.7 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 FUSC PF04632.7 ESL07473.1 - 2.3 6.5 6.1 0.79 8.0 2.5 1.4 2 0 0 2 2 2 0 Fusaric acid resistance protein family SBP_bac_7 PF03480.8 ESL07473.1 - 7.7 5.5 12.5 2.3 7.2 5.9 1.9 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 SEP PF08059.8 ESL07474.1 - 9.6e-09 35.4 0.0 2.2e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 SEP domain Cpn60_TCP1 PF00118.19 ESL07475.1 - 1.8e-114 383.0 9.4 2.2e-114 382.7 6.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EABR PF12180.3 ESL07475.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 TSG101 and ALIX binding domain of CEP55 Sec63 PF02889.11 ESL07477.1 - 3.2e-09 36.4 0.0 1e-05 24.9 0.0 2.4 2 1 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 ESL07477.1 - 6.5e-07 28.9 0.0 1.5e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PAF-AH_p_II PF03403.8 ESL07478.1 - 2.2e-25 88.7 0.0 3.2e-24 84.9 0.0 2.0 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 ESL07478.1 - 1.5e-10 41.0 0.0 2.2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL07478.1 - 2e-06 27.8 1.8 5.3e-06 26.4 1.3 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 ESL07478.1 - 7.8e-05 21.6 0.0 0.00058 18.8 0.0 2.0 1 1 0 1 1 1 1 Chlorophyllase enzyme Lipase_3 PF01764.20 ESL07478.1 - 0.001 18.6 0.0 0.0024 17.4 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.15 ESL07478.1 - 0.006 16.1 0.0 0.0095 15.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase PF07224.6 ESL07478.1 - 0.0061 15.4 0.1 1.5 7.5 0.0 2.2 2 0 0 2 2 2 2 Chlorophyllase Abhydrolase_3 PF07859.8 ESL07478.1 - 0.033 13.7 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.13 ESL07478.1 - 0.052 12.8 0.0 0.25 10.5 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family Esterase PF00756.15 ESL07478.1 - 0.089 12.2 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Mito_carr PF00153.22 ESL07479.1 - 4.1e-46 154.6 0.4 1.7e-16 59.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3815 PF12821.2 ESL07479.1 - 0.021 14.7 1.0 0.042 13.7 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3815) LRR_8 PF13855.1 ESL07480.1 - 5.4e-06 26.0 2.1 1.6e-05 24.5 1.4 1.9 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.1 ESL07480.1 - 0.00016 21.2 0.2 0.00044 19.8 0.1 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 ESL07480.1 - 0.0002 20.8 4.3 0.00022 20.7 0.4 2.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL07480.1 - 0.23 11.6 4.3 16 6.0 0.0 4.1 3 1 0 3 3 3 0 Leucine Rich Repeat Pkinase PF00069.20 ESL07481.1 - 7.8e-59 198.9 0.1 1.1e-58 198.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07481.1 - 1.5e-23 83.2 0.1 3.1e-23 82.1 0.1 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07481.1 - 1.7e-05 23.9 0.0 3.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like AbfB PF05270.8 ESL07481.1 - 0.076 12.7 0.4 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase B (ABFB) APH PF01636.18 ESL07481.1 - 0.29 10.8 0.0 0.29 10.8 0.0 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family CRAL_TRIO PF00650.15 ESL07482.1 - 2.3e-27 95.4 0.0 3.2e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 ESL07482.1 - 8.9e-06 25.6 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESL07482.1 - 1.7e-05 24.8 0.6 9.2e-05 22.5 0.1 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Gp_dh_C PF02800.15 ESL07483.1 - 1.8e-63 212.6 0.1 2.8e-63 212.0 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL07483.1 - 1.6e-55 187.1 0.1 2.8e-55 186.4 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 ESL07483.1 - 0.0045 16.8 0.7 0.014 15.3 0.1 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 ESL07483.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold PPR_3 PF13812.1 ESL07484.1 - 1.7e-08 34.0 10.6 0.24 11.7 0.0 6.8 7 0 0 7 7 7 3 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESL07484.1 - 1.4e-06 28.1 0.0 0.11 12.5 0.0 3.6 2 1 0 2 2 2 2 PPR repeat family PPR PF01535.15 ESL07484.1 - 0.00069 19.4 0.4 9 6.5 0.0 4.9 5 0 0 5 5 5 1 PPR repeat TPR_12 PF13424.1 ESL07484.1 - 0.022 14.6 3.9 0.37 10.7 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat HECT PF00632.20 ESL07485.1 - 9.8e-84 281.2 0.0 1.1e-83 281.0 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) M20_dimer PF07687.9 ESL07485.1 - 0.042 13.5 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase dimerisation domain Cytidylate_kin PF02224.13 ESL07486.1 - 0.011 15.1 1.1 0.024 14.0 0.8 1.5 1 0 0 1 1 1 0 Cytidylate kinase RimM PF01782.13 ESL07486.1 - 0.099 12.5 0.1 0.45 10.4 0.0 2.3 2 1 0 2 2 2 0 RimM N-terminal domain PPR PF01535.15 ESL07487.1 - 4.7e-07 29.3 3.2 0.26 11.3 0.0 5.9 6 0 0 6 6 6 2 PPR repeat PPR_2 PF13041.1 ESL07487.1 - 1.3e-06 28.2 0.0 0.12 12.3 0.0 5.5 6 0 0 6 6 6 1 PPR repeat family TPR_7 PF13176.1 ESL07487.1 - 3.5e-06 26.3 2.8 33 4.6 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat PPR_3 PF13812.1 ESL07487.1 - 1.3e-05 25.0 9.7 0.048 13.9 0.0 6.8 8 0 0 8 8 8 1 Pentatricopeptide repeat domain Apc3 PF12895.2 ESL07487.1 - 1.3e-05 25.2 0.1 1.7 8.8 0.0 4.5 3 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESL07487.1 - 3e-05 24.2 13.1 3.1 8.6 0.5 7.6 3 1 5 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07487.1 - 0.00043 20.5 2.8 0.85 10.0 0.0 4.2 2 2 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07487.1 - 0.00094 19.7 0.8 8.5 7.1 0.3 4.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.9 ESL07487.1 - 7.4 7.3 8.3 7.4 7.3 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Pro_isomerase PF00160.16 ESL07488.1 - 1.1e-15 58.1 0.0 1.4e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cytochrom_B561 PF03188.11 ESL07489.1 - 3e-11 43.2 10.8 5.6e-11 42.4 7.5 1.4 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 SdpI PF13630.1 ESL07489.1 - 0.00012 21.6 2.5 0.00012 21.6 1.8 3.3 3 2 1 4 4 4 1 SdpI/YhfL protein family DUF3413 PF11893.3 ESL07489.1 - 0.014 14.3 0.3 0.014 14.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) PepSY_TM_1 PF13172.1 ESL07489.1 - 0.036 13.8 0.1 0.036 13.8 0.0 3.4 3 0 0 3 3 3 0 PepSY-associated TM helix Surp PF01805.15 ESL07490.1 - 1.3e-12 47.1 0.1 2.2e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 Surp module DUF3948 PF13134.1 ESL07490.1 - 0.16 11.4 0.0 0.67 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3948) Cornichon PF03311.9 ESL07491.1 - 1.4e-12 47.8 6.0 1.4e-12 47.8 4.1 2.2 1 1 2 3 3 3 1 Cornichon protein HEAT PF02985.17 ESL07491.1 - 0.12 12.4 0.6 0.7 10.1 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat Rad51 PF08423.6 ESL07492.1 - 5.4e-08 32.0 1.2 0.0037 16.1 0.0 2.6 2 1 0 2 2 2 2 Rad51 AAA_25 PF13481.1 ESL07492.1 - 2.9e-06 26.8 3.0 1.7e-05 24.3 2.1 1.9 1 1 0 1 1 1 1 AAA domain KaiC PF06745.8 ESL07492.1 - 0.0057 15.7 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 KaiC RecA PF00154.16 ESL07492.1 - 0.013 14.5 0.3 0.069 12.2 0.0 1.9 2 0 0 2 2 2 0 recA bacterial DNA recombination protein Ipi1_N PF12333.3 ESL07493.1 - 0.00011 22.1 3.7 0.0035 17.2 0.2 2.9 3 0 0 3 3 3 2 Rix1 complex component involved in 60S ribosome maturation DUF4445 PF14574.1 ESL07493.1 - 0.066 11.4 0.0 0.1 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4445) HEAT PF02985.17 ESL07493.1 - 0.1 12.7 0.1 0.51 10.5 0.1 2.3 2 0 0 2 2 2 0 HEAT repeat HSP70 PF00012.15 ESL07494.1 - 3.8e-148 494.0 0.6 4.6e-148 493.8 0.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL07494.1 - 1.9e-14 53.0 0.2 1.8e-12 46.5 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.1 ESL07494.1 - 0.00049 19.9 2.4 0.21 11.4 0.0 3.5 2 1 0 2 2 2 2 Cell division protein FtsA Hydantoinase_A PF01968.13 ESL07494.1 - 0.027 13.5 6.1 1 8.3 0.4 2.9 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase Aldo_ket_red PF00248.16 ESL07495.1 - 3.3e-36 124.5 0.0 4.5e-36 124.1 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family ENT PF03735.9 ESL07495.1 - 0.02 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 ENT domain NCKAP5 PF15246.1 ESL07496.1 - 0.045 13.1 0.9 0.078 12.3 0.7 1.3 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Cytochrom_C_2 PF01322.15 ESL07496.1 - 0.074 13.5 2.0 5.4 7.5 0.2 3.2 2 1 1 3 3 3 0 Cytochrome C' CDC37_N PF03234.9 ESL07496.1 - 2.4 8.4 9.2 6 7.1 4.3 2.4 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Leu_zip PF15294.1 ESL07497.1 - 0.0024 17.0 5.6 0.0024 17.0 3.9 2.0 2 0 0 2 2 2 1 Leucine zipper eIF3g PF12353.3 ESL07497.1 - 2 8.3 4.7 0.41 10.5 0.8 1.6 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G APG6 PF04111.7 ESL07497.1 - 3.5 6.5 8.7 0.074 12.0 0.6 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 TBPIP PF07106.8 ESL07497.1 - 4.6 6.7 9.7 0.32 10.5 3.2 1.6 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Kinesin PF00225.18 ESL07498.1 - 2.1e-90 302.8 0.1 4.7e-90 301.6 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain SRPRB PF09439.5 ESL07498.1 - 0.074 12.2 1.4 0.23 10.6 1.0 1.8 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Atg14 PF10186.4 ESL07498.1 - 0.79 8.6 15.6 2.1 7.2 10.8 1.7 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 NAD_binding_5 PF07994.7 ESL07498.1 - 0.99 8.8 2.9 1 8.8 1.1 1.6 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase DUF4248 PF14053.1 ESL07498.1 - 1.8 8.2 4.6 6.6 6.3 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) DUF1323 PF07037.6 ESL07498.1 - 5.6 7.1 10.9 5.9 7.0 3.9 3.2 2 1 1 3 3 3 0 Putative transcription regulator (DUF1323) Sec7 PF01369.15 ESL07499.1 - 1.2e-29 103.3 0.0 2e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESL07499.1 - 7.8e-16 57.9 0.8 1.6e-15 56.9 0.1 1.9 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3380 PF11860.3 ESL07499.1 - 0.028 14.4 1.8 0.051 13.6 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3380) Flagellar_rod PF05149.7 ESL07500.1 - 1.2e-108 362.7 33.1 1.2e-108 362.7 23.0 3.0 2 1 1 3 3 3 2 Paraflagellar rod protein PAF-AH_p_II PF03403.8 ESL07501.1 - 3.7e-14 51.8 0.0 8.5e-14 50.6 0.0 1.5 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 ESL07501.1 - 0.0013 18.4 0.0 0.003 17.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESL07501.1 - 0.0065 16.3 0.1 0.014 15.2 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 ESL07501.1 - 0.018 14.6 0.0 0.028 13.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ESL07501.1 - 0.045 13.6 0.4 0.083 12.7 0.2 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family NUDIX_2 PF13869.1 ESL07502.1 - 8.7e-45 152.3 0.0 2.1e-44 151.1 0.0 1.6 1 1 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.23 ESL07502.1 - 0.0021 17.7 0.0 0.0069 16.0 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain IATP PF04568.7 ESL07502.1 - 0.086 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP MitMem_reg PF13012.1 ESL07503.1 - 3.2e-19 69.0 0.0 5.1e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 ESL07503.1 - 8.7e-19 67.3 0.0 4.9e-18 64.9 0.0 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease OsmC PF02566.14 ESL07503.1 - 0.075 13.2 0.1 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 OsmC-like protein Dicty_REP PF05086.7 ESL07504.1 - 5.4 4.6 3.9 8 4.0 2.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pkinase PF00069.20 ESL07506.1 - 5.9e-46 156.7 0.0 8.8e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07506.1 - 4.9e-33 114.2 0.0 6.6e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07506.1 - 3e-05 23.1 0.0 4.8e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL07506.1 - 0.0018 18.0 0.0 0.0044 16.7 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family TLD PF07534.11 ESL07507.1 - 4.3e-14 52.6 0.0 5.6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 TLD Ribosomal_S7 PF00177.16 ESL07508.1 - 3.8e-38 130.3 0.3 4.6e-38 130.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Pkinase PF00069.20 ESL07509.1 - 4.3e-35 121.1 0.2 8.8e-30 103.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07509.1 - 1.2e-22 80.2 0.2 2e-22 79.5 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL07509.1 - 0.00044 20.0 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family ABC2_membrane PF01061.19 ESL07510.1 - 2.1e-07 30.3 26.1 3.4e-07 29.6 18.1 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESL07510.1 - 8.4e-06 26.1 0.0 1.5e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter PDR_CDR PF06422.7 ESL07510.1 - 2.1 8.0 4.6 4.1 7.1 0.0 3.3 4 0 0 4 4 4 0 CDR ABC transporter DUF2614 PF11023.3 ESL07510.1 - 3.2 7.5 11.4 0.67 9.7 4.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) TruD PF01142.13 ESL07513.1 - 4.7e-47 160.4 0.0 5.8e-45 153.5 0.0 3.2 2 1 0 2 2 2 1 tRNA pseudouridine synthase D (TruD) PIG-H PF10181.4 ESL07514.1 - 5e-16 58.1 0.4 1.3e-15 56.7 0.2 1.8 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component MerC PF03203.9 ESL07514.1 - 0.11 12.8 0.5 0.11 12.8 0.3 2.0 2 0 0 2 2 2 0 MerC mercury resistance protein Dynein_light PF01221.13 ESL07515.1 - 3.5e-35 119.8 0.2 3.9e-35 119.7 0.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ground-like PF04155.13 ESL07515.1 - 0.078 13.2 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Ground-like domain Dynein_light PF01221.13 ESL07516.1 - 4.1e-44 148.4 0.7 4.9e-44 148.2 0.5 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Imm28 PF15574.1 ESL07516.1 - 0.0081 15.7 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Immunity protein 28 ECSIT PF06239.6 ESL07516.1 - 0.021 13.7 0.1 0.026 13.3 0.1 1.2 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway Peptidase_C3 PF00548.15 ESL07516.1 - 0.026 14.3 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) Vasohibin PF14822.1 ESL07516.1 - 0.076 12.0 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Vasohibin WIYLD PF10440.4 ESL07516.1 - 0.088 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain HTH_33 PF13592.1 ESL07516.1 - 0.1 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix DEAD PF00270.24 ESL07517.1 - 1e-31 109.6 0.0 2.7e-31 108.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL07517.1 - 2.6e-24 84.8 0.1 5.8e-24 83.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL07517.1 - 7.2e-06 25.9 0.0 2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESL07517.1 - 0.0057 15.5 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C_2 PF13307.1 ESL07517.1 - 0.073 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Helicase C-terminal domain DUF4137 PF13593.1 ESL07517.1 - 0.09 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) PUF PF00806.14 ESL07518.1 - 0.01 15.2 0.0 17 5.1 0.0 4.7 6 0 0 6 6 6 0 Pumilio-family RNA binding repeat TPR_11 PF13414.1 ESL07518.1 - 0.26 10.9 1.7 1.1 8.9 0.0 2.6 3 0 0 3 3 3 0 TPR repeat Arm PF00514.18 ESL07519.1 - 3.8e-52 172.4 28.0 7.5e-09 35.0 0.1 16.0 15 1 0 15 15 15 8 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 ESL07519.1 - 1.6e-06 27.4 1.8 0.003 16.7 0.0 4.8 3 1 4 7 7 7 3 Armadillo-like Atx10homo_assoc PF09759.4 ESL07519.1 - 5.1e-06 26.1 0.8 7.6 6.3 0.0 5.9 5 0 0 5 5 5 1 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.1 ESL07519.1 - 2.6e-05 24.4 14.9 0.33 11.2 0.0 6.7 6 1 1 7 7 7 3 HEAT repeats HEAT PF02985.17 ESL07519.1 - 0.0057 16.6 11.5 0.57 10.4 0.1 5.8 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 ESL07519.1 - 0.023 15.2 12.8 1.7 9.2 0.0 6.1 5 1 1 6 6 6 0 HEAT-like repeat Adaptin_N PF01602.15 ESL07519.1 - 0.024 12.9 0.1 1.5 7.0 0.0 2.9 3 0 0 3 3 3 0 Adaptin N terminal region E3_UbLigase_R4 PF13764.1 ESL07519.1 - 0.053 11.4 0.6 4.6 5.0 0.0 3.2 2 1 1 4 4 4 0 E3 ubiquitin-protein ligase UBR4 DUF1843 PF08898.5 ESL07519.1 - 0.082 12.9 3.2 0.35 10.9 2.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) Radical_SAM PF04055.16 ESL07520.1 - 3.8e-17 62.9 0.0 5.8e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Lipid_bd PF12888.2 ESL07521.1 - 0.0048 16.7 0.0 0.0073 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipid-binding putative hydrolase Fib_alpha PF08702.5 ESL07524.1 - 0.13 12.3 13.0 0.22 11.6 4.2 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Mit_ribos_Mrp51 PF11709.3 ESL07524.1 - 0.14 11.3 2.7 0.22 10.7 1.9 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit Lebercilin PF15619.1 ESL07524.1 - 0.17 11.2 23.4 0.07 12.5 12.5 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Bacillus_HBL PF05791.6 ESL07524.1 - 0.55 9.5 7.1 0.3 10.4 0.1 2.5 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Pkinase PF00069.20 ESL07525.1 - 7.3e-64 215.4 0.0 9.1e-64 215.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07525.1 - 2e-39 135.2 0.0 2.8e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase zinc_ribbon_2 PF13240.1 ESL07525.1 - 1.4e-05 24.3 2.5 2.9e-05 23.4 1.7 1.5 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESL07525.1 - 2.8e-05 23.1 2.6 6.2e-05 22.0 1.8 1.5 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 ESL07525.1 - 0.0041 16.9 5.4 0.0094 15.7 3.8 1.6 1 0 0 1 1 1 1 Double zinc ribbon Kinase-like PF14531.1 ESL07525.1 - 0.013 14.5 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESL07525.1 - 0.014 15.1 0.0 0.15 11.7 0.0 2.3 1 1 2 3 3 3 0 Phosphotransferase enzyme family UPF0547 PF10571.4 ESL07525.1 - 0.052 13.2 7.3 36 4.1 5.0 2.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 NOB1_Zn_bind PF08772.6 ESL07525.1 - 0.08 12.7 3.4 0.17 11.7 2.4 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.6 ESL07525.1 - 0.46 10.0 7.6 0.088 12.3 0.5 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HEAT PF02985.17 ESL07527.1 - 0.0013 18.5 2.9 0.035 14.1 0.2 4.1 3 0 0 3 3 3 1 HEAT repeat RA PF00788.18 ESL07528.1 - 0.16 12.4 2.1 0.3 11.5 0.2 2.2 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain SHIPPO-rpt PF07004.7 ESL07530.1 - 1.5e-08 35.1 41.7 0.017 16.0 0.2 10.5 10 1 0 10 10 10 6 Sperm-tail PG-rich repeat Kelch_6 PF13964.1 ESL07532.1 - 2.3e-17 62.3 7.2 0.00059 19.8 0.1 6.7 4 2 2 6 6 6 5 Kelch motif Kelch_5 PF13854.1 ESL07532.1 - 1.2e-15 57.0 8.2 0.0015 18.4 0.1 6.7 5 2 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESL07532.1 - 2.8e-15 55.8 10.4 2.5e-07 30.3 0.0 6.8 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL07532.1 - 6.3e-15 54.8 12.1 0.00038 20.5 0.0 6.3 5 2 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESL07532.1 - 1.1e-14 53.7 3.5 7.2e-06 25.4 0.1 5.9 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESL07532.1 - 5.5e-13 48.1 4.4 0.03 14.0 0.0 6.1 5 1 0 5 5 5 4 Kelch motif HA2 PF04408.18 ESL07533.1 - 1.8e-15 56.8 0.1 4e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESL07533.1 - 2.5e-11 43.2 0.1 8e-11 41.6 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain R3H PF01424.17 ESL07533.1 - 1.5e-10 40.6 0.0 4.5e-10 39.0 0.0 1.9 1 0 0 1 1 1 1 R3H domain DEAD PF00270.24 ESL07533.1 - 1.6e-08 34.2 0.0 4.8e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESL07533.1 - 0.0012 19.0 0.0 0.003 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESL07533.1 - 0.014 14.3 0.0 0.029 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.10 ESL07533.1 - 0.13 12.1 0.0 18 5.1 0.0 3.6 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit DUF4604 PF15377.1 ESL07533.1 - 1.2 9.3 4.1 0.92 9.7 1.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Pep_deformylase PF01327.16 ESL07534.1 - 6.5e-23 80.8 0.0 9.6e-23 80.3 0.0 1.2 1 0 0 1 1 1 1 Polypeptide deformylase Pkinase PF00069.20 ESL07536.1 - 8.5e-66 221.7 0.0 1.2e-65 221.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07536.1 - 2.2e-47 161.3 0.0 3.2e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07536.1 - 9.8e-07 28.0 0.1 2.5e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL07536.1 - 0.01 15.5 0.0 2.3 7.9 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family PBP1_TM PF14812.1 ESL07537.1 - 1.1 9.6 4.7 2.4 8.5 3.2 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BNR_3 PF13859.1 ESL07538.1 - 7.1e-17 61.4 0.0 1.1e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain AAA PF00004.24 ESL07539.1 - 3.6e-96 318.4 0.0 2.1e-47 160.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 ESL07539.1 - 3.6e-20 71.7 0.4 1.1e-19 70.1 0.1 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.7 ESL07539.1 - 2.2e-13 49.7 0.0 9.8e-06 24.7 0.0 2.6 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL07539.1 - 5e-13 49.4 0.1 2.8e-05 24.1 0.0 3.5 2 2 1 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 ESL07539.1 - 2.3e-12 47.7 0.1 5.7e-05 23.9 0.0 3.4 3 1 0 3 3 2 2 AAA domain AAA_33 PF13671.1 ESL07539.1 - 3.8e-12 46.2 0.0 4.5e-06 26.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 ESL07539.1 - 2.9e-11 43.5 0.0 3.8e-06 26.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL07539.1 - 8.3e-11 42.1 0.1 0.0013 18.8 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESL07539.1 - 1e-10 41.5 0.4 7.9e-05 22.4 0.0 3.9 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.12 ESL07539.1 - 3.7e-10 39.3 0.0 8.1e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_14 PF13173.1 ESL07539.1 - 3.6e-09 36.6 0.0 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ESL07539.1 - 4.2e-09 35.7 0.0 0.0019 17.3 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin TIP49 PF06068.8 ESL07539.1 - 1.5e-08 33.7 0.0 0.00042 19.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_18 PF13238.1 ESL07539.1 - 7.6e-08 32.7 0.0 0.0064 16.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 ESL07539.1 - 9.5e-08 31.6 2.6 0.016 14.6 0.1 4.0 2 2 1 3 3 3 2 AAA domain IstB_IS21 PF01695.12 ESL07539.1 - 1.6e-07 30.9 0.1 0.012 14.9 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL07539.1 - 3e-07 30.5 0.0 0.0059 16.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.16 ESL07539.1 - 4.6e-07 29.2 0.2 0.028 13.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESL07539.1 - 1.1e-06 28.2 0.6 0.032 13.9 0.1 2.7 2 0 0 2 2 2 2 Part of AAA domain AAA_28 PF13521.1 ESL07539.1 - 2.8e-06 27.3 0.0 0.16 11.8 0.0 3.2 3 0 0 3 3 2 2 AAA domain Arch_ATPase PF01637.13 ESL07539.1 - 4.6e-06 26.5 0.0 0.15 11.7 0.1 3.3 2 1 1 3 3 3 2 Archaeal ATPase NACHT PF05729.7 ESL07539.1 - 1.5e-05 24.6 0.1 0.14 11.7 0.0 3.4 3 1 1 4 4 3 2 NACHT domain ResIII PF04851.10 ESL07539.1 - 1.7e-05 24.6 0.0 0.0054 16.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ABC_tran PF00005.22 ESL07539.1 - 1.9e-05 24.9 0.0 0.052 13.8 0.0 3.0 2 1 0 2 2 2 1 ABC transporter Sigma54_activ_2 PF14532.1 ESL07539.1 - 2.5e-05 24.3 0.0 0.057 13.4 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.12 ESL07539.1 - 3.3e-05 22.9 0.0 0.047 12.5 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 ESL07539.1 - 5.1e-05 22.7 0.0 0.11 11.9 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_24 PF13479.1 ESL07539.1 - 7.3e-05 22.4 0.0 0.33 10.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.13 ESL07539.1 - 8.2e-05 22.3 0.0 0.13 11.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial dnaA protein Viral_helicase1 PF01443.13 ESL07539.1 - 8.9e-05 22.1 0.0 0.012 15.1 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Vps4_C PF09336.5 ESL07539.1 - 9.3e-05 22.2 0.1 0.0027 17.5 0.0 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain KaiC PF06745.8 ESL07539.1 - 0.00012 21.2 2.0 1.3 8.0 0.0 3.7 3 1 1 4 4 4 1 KaiC NB-ARC PF00931.17 ESL07539.1 - 0.00027 19.8 0.1 0.59 8.9 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_3 PF07726.6 ESL07539.1 - 0.00057 19.5 0.0 1.3 8.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESL07539.1 - 0.00064 19.4 1.6 2.6 7.7 0.0 4.2 3 1 1 4 4 4 1 NTPase PhoH PF02562.11 ESL07539.1 - 0.0011 18.2 0.2 0.73 9.0 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein Cytidylate_kin2 PF13189.1 ESL07539.1 - 0.0034 17.2 0.0 0.38 10.6 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family DUF2075 PF09848.4 ESL07539.1 - 0.0035 16.3 0.0 0.94 8.3 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) SKI PF01202.17 ESL07539.1 - 0.0051 16.6 0.0 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase AAA_23 PF13476.1 ESL07539.1 - 0.0054 17.0 0.0 4.9 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESL07539.1 - 0.0058 16.1 0.2 4.3 6.6 0.0 3.6 3 1 1 4 4 4 0 AAA-like domain UPF0079 PF02367.12 ESL07539.1 - 0.013 15.1 0.0 6.5 6.4 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 DEAD PF00270.24 ESL07539.1 - 0.015 14.8 0.1 7.2 6.0 0.0 3.3 3 1 0 4 4 3 0 DEAD/DEAH box helicase DUF815 PF05673.8 ESL07539.1 - 0.026 13.4 0.0 4.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SE PF00437.15 ESL07539.1 - 0.027 13.3 0.0 9.3 5.0 0.0 3.1 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_21 PF13304.1 ESL07539.1 - 0.031 14.2 0.4 13 5.6 0.3 3.2 2 1 0 2 2 2 0 AAA domain KTI12 PF08433.5 ESL07539.1 - 0.046 12.9 0.1 8.1 5.5 0.1 2.5 2 1 0 2 2 2 0 Chromatin associated protein KTI12 AAA_29 PF13555.1 ESL07539.1 - 0.061 12.8 0.0 9.1 5.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Molydop_binding PF01568.16 ESL07539.1 - 0.064 13.0 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain AAA_30 PF13604.1 ESL07539.1 - 0.15 11.6 0.0 20 4.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.11 ESL07539.1 - 0.16 10.7 0.0 11 4.7 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase ArfGap PF01412.13 ESL07540.1 - 2e-24 85.6 0.0 3.1e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase PF00069.20 ESL07542.1 - 3.2e-54 183.8 0.0 4.6e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07542.1 - 8.8e-35 120.0 0.0 1.7e-34 119.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07542.1 - 1.5e-06 27.4 0.0 1.5e-05 24.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like PH PF00169.24 ESL07542.1 - 5.9e-06 26.4 0.0 5.6e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 PH domain PH_9 PF15410.1 ESL07542.1 - 0.011 15.8 0.0 0.048 13.8 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Actin PF00022.14 ESL07543.1 - 4e-88 295.4 0.0 4.5e-88 295.3 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESL07543.1 - 0.025 13.1 0.0 1.5 7.3 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein VRR_NUC PF08774.6 ESL07545.1 - 5e-15 55.3 0.0 2.4e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 VRR-NUC domain MFS_1 PF07690.11 ESL07546.1 - 3.3e-14 52.3 16.4 9.7e-07 27.8 0.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 ESL07546.1 - 0.0034 15.5 0.0 0.0052 14.9 0.0 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF4131 PF13567.1 ESL07546.1 - 0.004 16.5 4.6 6.2 6.2 0.2 3.3 3 0 0 3 3 3 3 Domain of unknown function (DUF4131) YfhO PF09586.5 ESL07546.1 - 4 5.3 7.1 0.75 7.7 2.0 1.8 2 0 0 2 2 2 0 Bacterial membrane protein YfhO Cpn60_TCP1 PF00118.19 ESL07547.1 - 5.4e-149 496.9 0.4 6.2e-149 496.7 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ATP-synt_ab PF00006.20 ESL07548.1 - 4.6e-15 55.6 0.1 7e-15 55.1 0.1 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL07548.1 - 0.0019 18.6 0.2 0.0069 16.8 0.1 2.0 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain Nol1_Nop2_Fmu PF01189.12 ESL07549.1 - 7.8e-24 84.5 0.0 1.1e-22 80.7 0.0 2.3 1 1 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 ESL07549.1 - 0.00062 19.7 0.0 0.0044 17.0 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain FtsJ PF01728.14 ESL07549.1 - 0.051 13.5 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF211 PF02680.9 ESL07549.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 AdoHcyase PF05221.12 ESL07551.1 - 9.2e-140 464.1 0.0 1e-139 463.9 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 ESL07551.1 - 2.7e-86 287.4 1.2 3.8e-86 286.9 0.9 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 ESL07551.1 - 8.5e-10 38.0 0.0 1.6e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESL07551.1 - 2.2e-05 23.8 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 ESL07551.1 - 2.4e-05 24.3 0.2 0.00012 22.0 0.1 2.1 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.1 ESL07551.1 - 0.0015 18.7 0.1 0.0034 17.6 0.1 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Oxidored_nitro PF00148.14 ESL07551.1 - 0.008 14.8 0.1 0.15 10.6 0.0 2.1 1 1 1 2 2 2 1 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.16 ESL07551.1 - 0.017 14.6 0.1 0.04 13.5 0.0 1.7 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.15 ESL07551.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF4267 PF14087.1 ESL07552.1 - 0.088 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) zf-rbx1 PF12678.2 ESL07553.1 - 1.4e-06 28.2 4.2 2.3e-06 27.6 2.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESL07553.1 - 4.3e-06 26.4 5.0 9.1e-06 25.4 3.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL07553.1 - 0.00017 21.5 4.7 0.00036 20.4 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL07553.1 - 0.00062 19.4 2.0 0.0011 18.6 1.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL07553.1 - 0.0014 18.2 4.4 0.0025 17.4 3.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL07553.1 - 0.0016 18.2 1.7 0.0026 17.5 1.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 ESL07553.1 - 0.0024 17.5 1.9 0.004 16.7 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESL07553.1 - 0.33 10.8 3.9 1.1 9.1 2.9 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.6 ESL07553.1 - 0.47 10.4 3.3 0.89 9.6 2.3 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.3 ESL07553.1 - 0.72 9.8 3.8 1.4 8.9 0.8 2.2 1 1 1 2 2 2 0 FANCL C-terminal domain Zip PF02535.17 ESL07554.1 - 5e-21 75.0 16.8 5.6e-21 74.8 11.7 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF3360 PF11840.3 ESL07554.1 - 0.13 10.5 8.0 0.14 10.4 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3360) DnaJ PF00226.26 ESL07556.1 - 4.5e-19 67.9 1.0 1.8e-18 65.9 0.0 2.6 2 0 0 2 2 2 1 DnaJ domain Actin PF00022.14 ESL07557.1 - 3.7e-122 407.5 0.0 4.3e-122 407.3 0.0 1.0 1 0 0 1 1 1 1 Actin Transket_pyr PF02779.19 ESL07558.1 - 6.4e-46 156.0 0.0 2e-45 154.4 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESL07558.1 - 3.3e-39 133.6 0.1 3.6e-37 127.0 0.0 2.3 2 0 0 2 2 2 2 Transketolase, C-terminal domain HEAT PF02985.17 ESL07559.1 - 9.8e-10 37.6 23.5 0.08 13.0 0.2 9.7 9 1 1 10 10 10 3 HEAT repeat HEAT_2 PF13646.1 ESL07559.1 - 1.2e-05 25.4 27.2 0.19 12.0 0.4 7.2 5 2 1 6 6 6 3 HEAT repeats HEAT_EZ PF13513.1 ESL07559.1 - 0.81 10.2 23.9 1 9.9 0.1 7.2 8 0 0 8 8 8 0 HEAT-like repeat AAA_33 PF13671.1 ESL07560.1 - 2.7e-09 37.0 1.0 2.1e-08 34.1 0.1 2.7 2 1 0 2 2 2 1 AAA domain tRNA_lig_kinase PF08303.6 ESL07560.1 - 9.1e-08 32.1 0.0 1.4e-06 28.2 0.0 2.1 1 1 0 1 1 1 1 tRNA ligase kinase domain AAA_16 PF13191.1 ESL07560.1 - 1.8e-06 28.1 0.3 7.5e-05 22.7 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain tRNA_lig_CPD PF08302.6 ESL07560.1 - 5.1e-06 25.8 0.0 9.6e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 Fungal tRNA ligase phosphodiesterase domain AAA_22 PF13401.1 ESL07560.1 - 0.00044 20.3 0.1 0.1 12.7 0.0 3.1 2 1 1 3 3 3 1 AAA domain MobB PF03205.9 ESL07560.1 - 0.0027 17.4 0.0 0.0051 16.5 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.12 ESL07560.1 - 0.0064 16.0 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 ESL07560.1 - 0.027 14.7 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.1 ESL07560.1 - 0.05 14.4 0.0 0.1 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 ESL07560.1 - 0.061 13.2 0.0 0.081 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESL07560.1 - 0.082 11.9 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.1 ESL07560.1 - 0.1 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.17 ESL07560.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 ESL07560.1 - 0.16 11.8 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Skp1 PF01466.14 ESL07562.1 - 4.2e-19 68.3 0.2 6.3e-19 67.7 0.2 1.2 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Strumpellin PF10266.4 ESL07563.1 - 0.13 9.6 0.2 0.19 9.1 0.1 1.2 1 0 0 1 1 1 0 Hereditary spastic paraplegia protein strumpellin CCDC-167 PF15188.1 ESL07564.1 - 1.6 8.7 4.8 1.2 9.1 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 RPN7 PF10602.4 ESL07565.1 - 1.2e-51 174.6 0.8 2.2e-51 173.7 0.1 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 ESL07565.1 - 1.3e-11 44.7 0.0 2.7e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 ESL07565.1 - 0.052 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 COP9 signalosome, subunit CSN8 FeoC PF09012.5 ESL07565.1 - 0.12 12.0 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 FeoC like transcriptional regulator SapB_1 PF05184.10 ESL07566.1 - 0.014 15.1 2.0 0.26 11.1 0.2 2.8 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF3981 PF13139.1 ESL07567.1 - 2.3 8.2 5.1 0.48 10.4 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3981) ERCC4 PF02732.10 ESL07568.1 - 3.7e-20 72.1 0.0 5.9e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain DUF2072 PF09845.4 ESL07569.1 - 0.44 10.4 0.5 0.87 9.5 0.3 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) DUF4618 PF15397.1 ESL07570.1 - 0.064 12.5 37.5 0.031 13.6 18.9 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) APG6 PF04111.7 ESL07570.1 - 6.6 5.6 35.8 0.48 9.4 9.1 2.5 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF775 PF05603.7 ESL07571.1 - 2.8e-29 102.1 0.0 3.4e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Peptidase_M8 PF01457.11 ESL07572.1 - 3e-127 425.1 0.0 3.6e-127 424.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_3 PF13582.1 ESL07572.1 - 0.00026 21.4 0.1 0.00059 20.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.3 ESL07572.1 - 0.021 14.1 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_4 PF13583.1 ESL07572.1 - 0.048 13.1 0.1 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.19 ESL07572.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.1 ESL07572.1 - 0.31 10.9 2.1 0.2 11.5 0.2 1.5 2 0 0 2 2 2 0 Metallo-peptidase family M12 Thioredoxin_8 PF13905.1 ESL07573.1 - 1.8e-27 95.3 0.0 2.4e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 ESL07573.1 - 6.5e-10 38.7 0.0 1.5e-09 37.5 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.15 ESL07573.1 - 8.4e-10 38.2 0.0 1.1e-07 31.5 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin Redoxin PF08534.5 ESL07573.1 - 9e-09 35.0 0.0 1.2e-08 34.6 0.0 1.2 1 1 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.1 ESL07573.1 - 7.4e-07 29.3 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 ESL07573.1 - 6.4e-05 22.5 0.0 0.0015 18.0 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 ESL07573.1 - 8.3e-05 22.5 0.0 0.00013 21.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.1 ESL07573.1 - 0.0002 20.8 0.0 0.00066 19.2 0.0 1.8 1 1 0 1 1 1 1 F plasmid transfer operon protein DUF953 PF06110.6 ESL07573.1 - 0.019 14.4 0.0 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) NADH_4Fe-4S PF10589.4 ESL07573.1 - 0.085 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Aldo_ket_red PF00248.16 ESL07574.1 - 7e-63 212.0 0.0 8.1e-63 211.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Arm PF00514.18 ESL07575.1 - 1.3e-23 81.9 22.7 0.0024 17.6 0.0 13.1 15 0 0 15 15 15 9 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 ESL07575.1 - 7.9e-11 41.5 13.1 0.13 12.0 0.1 8.0 6 3 1 7 7 7 4 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.1 ESL07575.1 - 1.2e-09 38.2 12.7 0.29 11.4 0.1 7.0 2 2 2 6 6 6 5 HEAT repeats V-ATPase_H_C PF11698.3 ESL07575.1 - 0.044 13.6 1.0 11 5.9 0.0 4.0 4 0 0 4 4 4 0 V-ATPase subunit H Cullin PF00888.17 ESL07576.1 - 1.8e-62 211.7 2.3 2e-62 211.5 0.6 1.6 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 ESL07576.1 - 1.7e-13 50.1 0.0 5e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain TYW3 PF02676.9 ESL07577.1 - 1.1e-41 142.1 0.0 2.9e-41 140.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase TYW3 tRNA-synt_1b PF00579.20 ESL07578.1 - 2.8e-49 167.8 0.0 6.4e-47 160.0 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (W and Y) LRR_4 PF12799.2 ESL07580.1 - 1.2e-12 47.1 20.4 3.3e-07 29.7 2.4 3.9 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL07580.1 - 2e-10 40.2 16.0 4.1e-07 29.6 4.6 3.1 2 1 1 3 3 3 2 Leucine rich repeat LRR_9 PF14580.1 ESL07580.1 - 5.4e-09 35.8 3.6 2.8e-08 33.5 0.8 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 ESL07580.1 - 7.1e-05 22.3 10.4 0.22 11.7 0.1 5.4 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.1 ESL07580.1 - 0.00016 21.4 13.5 0.023 14.7 0.1 4.7 3 1 1 4 4 4 2 Leucine Rich repeat LRR_7 PF13504.1 ESL07580.1 - 0.022 14.8 13.2 5.3 7.6 0.0 5.7 6 0 0 6 6 6 0 Leucine rich repeat PAC2 PF09754.4 ESL07580.1 - 0.11 12.3 0.2 0.4 10.5 0.1 1.9 2 0 0 2 2 2 0 PAC2 family Fib_alpha PF08702.5 ESL07580.1 - 1.1 9.3 12.9 0.74 9.9 1.3 3.0 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Pkinase PF00069.20 ESL07581.1 - 1.9e-33 115.6 0.1 2.5e-15 56.3 0.0 3.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07581.1 - 2.6e-08 33.2 0.1 2e-05 23.8 0.1 3.5 4 0 0 4 4 4 2 Protein tyrosine kinase Kinase-like PF14531.1 ESL07581.1 - 0.0013 17.7 0.2 0.03 13.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Ribul_P_3_epim PF00834.14 ESL07582.1 - 2.7e-69 232.3 0.3 3.2e-69 232.0 0.2 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.19 ESL07582.1 - 0.00044 19.7 0.6 0.002 17.5 0.2 2.1 2 1 0 2 2 2 1 Orotidine 5'-phosphate decarboxylase / HUMPS family His_biosynth PF00977.16 ESL07582.1 - 0.0021 17.3 0.1 0.043 13.0 0.0 2.1 1 1 1 2 2 2 1 Histidine biosynthesis protein PcrB PF01884.12 ESL07582.1 - 0.0044 16.2 0.3 0.0064 15.7 0.2 1.3 1 1 0 1 1 1 1 PcrB family QRPTase_C PF01729.14 ESL07582.1 - 0.019 14.5 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Peptidase_C12 PF01088.16 ESL07583.1 - 2.6e-56 190.1 0.0 3.8e-56 189.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 BBP1_C PF15272.1 ESL07583.1 - 0.12 11.8 1.9 0.2 11.1 1.3 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Ras PF00071.17 ESL07584.1 - 3.1e-48 163.2 0.5 3.8e-48 162.9 0.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL07584.1 - 1.2e-17 64.4 0.1 2.4e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL07584.1 - 9.1e-08 31.5 0.1 1.2e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESL07584.1 - 1.3e-05 25.1 0.0 1.8e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ESL07584.1 - 0.00088 18.7 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.7 ESL07584.1 - 0.0033 16.5 0.1 0.0079 15.3 0.0 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.13 ESL07584.1 - 0.0084 15.3 0.2 0.25 10.6 0.1 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.5 ESL07584.1 - 0.025 13.8 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UPF0066 PF01980.11 ESL07586.1 - 7.3e-31 106.6 0.0 1.2e-30 105.8 0.0 1.4 1 1 0 1 1 1 1 Uncharacterised protein family UPF0066 Kinesin PF00225.18 ESL07587.1 - 6.4e-84 281.5 0.0 7.4e-84 281.3 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain DUF4201 PF13870.1 ESL07588.1 - 2e-35 121.8 27.2 2e-35 121.8 18.9 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4201) DUF4062 PF13271.1 ESL07588.1 - 0.5 10.4 3.8 14 5.7 0.0 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4062) Ribosomal_60s PF00428.14 ESL07588.1 - 1.4 9.3 14.6 0.37 11.1 7.3 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Tnp_P_element PF12017.3 ESL07588.1 - 1.9 7.6 8.5 1.2 8.3 1.1 2.5 1 1 1 2 2 2 0 Transposase protein PI3_PI4_kinase PF00454.22 ESL07590.1 - 0.066 12.6 0.0 0.24 10.8 0.0 1.9 1 1 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase IU_nuc_hydro PF01156.14 ESL07592.1 - 5.2e-28 98.1 0.1 6.3e-28 97.9 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Fringe PF02434.11 ESL07593.1 - 0.00012 21.3 0.2 0.0012 18.1 0.1 2.1 1 1 0 1 1 1 1 Fringe-like DUF2721 PF11026.3 ESL07594.1 - 0.0017 18.0 1.6 0.0017 18.0 1.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2721) DUF1430 PF07242.6 ESL07594.1 - 9.9 6.2 8.1 1.9 8.6 2.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1430) Ribosomal_L3 PF00297.17 ESL07595.1 - 3e-07 30.1 0.8 3.6e-07 29.8 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L3 TPR_11 PF13414.1 ESL07596.1 - 2e-11 43.3 12.6 0.0017 17.9 0.0 6.6 6 1 0 6 6 6 3 TPR repeat TPR_2 PF07719.12 ESL07596.1 - 1.5e-08 33.9 15.3 0.22 11.5 0.0 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL07596.1 - 1.6e-08 34.7 6.6 0.0015 18.7 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL07596.1 - 4.1e-06 26.1 0.0 0.023 14.4 0.0 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07596.1 - 7e-06 26.2 24.8 0.33 11.7 0.0 9.8 9 1 2 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07596.1 - 1.4e-05 25.6 26.4 0.0072 16.9 0.0 7.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07596.1 - 5.8e-05 22.5 3.7 6.3 6.8 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL07596.1 - 0.0012 18.8 0.0 2.7 8.4 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat DEAD PF00270.24 ESL07597.1 - 1.5e-47 161.2 0.0 8.2e-46 155.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL07597.1 - 3.3e-25 87.7 0.1 8e-25 86.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 ESL07597.1 - 0.00079 19.1 0.0 0.54 10.0 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain ResIII PF04851.10 ESL07597.1 - 0.0014 18.5 0.0 0.012 15.4 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 ESL07597.1 - 0.0019 17.8 0.0 0.096 12.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain A_deaminase PF00962.17 ESL07600.1 - 5.9e-07 28.7 2.2 0.17 10.7 0.0 3.5 4 0 0 4 4 4 3 Adenosine/AMP deaminase Formyl_trans_N PF00551.14 ESL07601.1 - 9.6e-20 70.8 0.0 1.7e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase DnaJ PF00226.26 ESL07602.1 - 2e-05 24.2 0.0 5.6e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain ECH_C PF13766.1 ESL07603.1 - 1.5e-07 31.5 0.0 0.00052 20.1 0.0 3.4 3 0 0 3 3 3 2 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 ESL07603.1 - 3.1e-07 29.7 0.0 1.1e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family DUF4136 PF13590.1 ESL07603.1 - 0.0034 17.4 0.0 0.0071 16.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4136) tRNA-synt_1e PF01406.14 ESL07604.1 - 4.8e-111 370.6 0.0 1.5e-110 369.0 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 ESL07604.1 - 4.8e-05 22.1 0.3 0.0049 15.5 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ESL07604.1 - 6.7e-05 21.0 0.1 0.021 12.8 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.6 ESL07604.1 - 0.037 14.2 0.1 0.27 11.5 0.0 2.5 2 0 0 2 2 2 0 DALR domain NAGidase PF07555.8 ESL07604.1 - 0.038 12.9 0.9 0.067 12.1 0.6 1.3 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase Sec1 PF00995.18 ESL07605.1 - 8.6e-77 259.0 0.1 9.9e-77 258.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family UPF0167 PF03691.9 ESL07605.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) DHC_N2 PF08393.8 ESL07605.1 - 0.083 11.3 0.1 0.17 10.3 0.1 1.4 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 DUF2106 PF09879.4 ESL07605.1 - 0.09 12.1 0.0 0.31 10.3 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2106) 2OG-FeII_Oxy_2 PF13532.1 ESL07607.1 - 2.5e-10 40.5 0.0 3.7e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESL07607.1 - 2.5e-08 34.0 0.0 5.3e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ribosomal_S8 PF00410.14 ESL07609.1 - 2.8e-23 82.1 0.0 3.9e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 FGGY_N PF00370.16 ESL07610.1 - 7.5e-62 208.8 0.0 1e-61 208.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 ESL07610.1 - 7e-55 185.7 1.8 1.2e-54 185.0 1.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.15 ESL07610.1 - 0.0034 16.7 0.0 2.2 7.5 0.0 2.3 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family OST-HTH PF12872.2 ESL07611.1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 OST-HTH/LOTUS domain Pkinase PF00069.20 ESL07612.1 - 2.1e-44 151.6 0.0 2.8e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07612.1 - 6.9e-22 77.7 0.0 4e-21 75.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESL07612.1 - 0.037 13.0 0.1 0.068 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_A PF00476.15 ESL07612.1 - 0.22 10.1 0.0 0.33 9.5 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase family A BT1 PF03092.11 ESL07613.1 - 4.6e-75 252.9 4.2 5e-75 252.8 2.9 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 ESL07613.1 - 2e-06 26.7 8.1 0.00032 19.5 0.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Na_Ca_ex PF01699.19 ESL07613.1 - 0.0012 18.4 4.4 0.0035 16.9 1.5 2.1 2 0 0 2 2 2 1 Sodium/calcium exchanger protein Thia_YuaJ PF09515.5 ESL07613.1 - 0.0095 15.7 6.3 0.013 15.2 4.3 1.1 1 0 0 1 1 1 1 Thiamine transporter protein (Thia_YuaJ) DUF846 PF05832.7 ESL07613.1 - 0.29 10.8 4.6 3.9 7.1 0.1 2.5 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF846) Pkinase PF00069.20 ESL07614.1 - 1e-57 195.2 0.0 3.2e-57 193.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07614.1 - 2.9e-36 124.8 0.0 6.2e-36 123.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 ESL07614.1 - 1.9e-07 31.1 0.4 1.7e-06 28.0 0.1 2.7 2 1 0 2 2 2 1 FHA domain Kinase-like PF14531.1 ESL07614.1 - 2.6e-05 23.3 0.0 5.6e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PAS PF00989.19 ESL07614.1 - 0.0047 16.6 0.0 5.6 6.7 0.0 3.3 3 0 0 3 3 3 2 PAS fold DUF572 PF04502.8 ESL07616.1 - 4.5e-15 55.7 10.2 7.9e-15 54.8 7.1 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF572) Zn_Tnp_IS1595 PF12760.2 ESL07616.1 - 1.7 8.4 7.9 0.35 10.6 0.7 2.7 3 0 0 3 3 3 0 Transposase zinc-ribbon domain WD40 PF00400.27 ESL07617.1 - 5.1e-13 48.3 3.6 6.9e-06 25.7 0.0 5.7 7 0 0 7 7 7 4 WD domain, G-beta repeat DUF4539 PF15072.1 ESL07618.1 - 8.6e-24 83.0 0.1 1.5e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) Prenyltransf PF01255.14 ESL07619.1 - 4.1e-51 173.2 0.5 1.3e-48 165.0 0.0 2.1 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase Maf1 PF09174.5 ESL07619.1 - 0.057 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Maf1 regulator PAP_assoc PF03828.14 ESL07620.1 - 3.3e-11 42.9 0.1 6.2e-11 42.0 0.1 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase LacAB_rpiB PF02502.13 ESL07621.1 - 3.1e-50 169.4 0.4 3.6e-50 169.2 0.3 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase MPC PF03650.8 ESL07622.1 - 1.5e-14 53.9 0.4 1.8e-14 53.6 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) HSP20 PF00011.16 ESL07623.1 - 9.1e-19 67.2 0.0 1e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family CEP76-C2 PF15627.1 ESL07625.1 - 1.8e-38 131.5 0.0 2.7e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 CEP76 C2 domain BDM PF10684.4 ESL07625.1 - 0.13 12.5 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative biofilm-dependent modulation protein Nrap PF03813.9 ESL07629.1 - 6.5e-22 76.9 0.0 7.3e-22 76.8 0.0 1.1 1 0 0 1 1 1 1 Nrap protein SET PF00856.23 ESL07630.1 - 1.3e-12 48.3 0.0 4.1e-12 46.6 0.0 1.7 1 1 0 1 1 1 1 SET domain RRM_1 PF00076.17 ESL07631.1 - 6.2e-16 57.7 0.0 7.6e-16 57.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL07631.1 - 5.5e-11 42.2 0.0 6.9e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07631.1 - 3.9e-05 23.4 0.0 5.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.17 ESL07632.1 - 1.9e-23 82.9 9.3 2.3e-23 82.7 6.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Peptidase_C1 PF00112.18 ESL07633.1 - 9.2e-58 195.7 1.3 1.1e-57 195.4 0.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.8 ESL07633.1 - 2.5e-08 33.3 0.1 4.3e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.10 ESL07633.1 - 0.0094 14.5 1.6 0.022 13.2 0.3 1.8 2 0 0 2 2 2 1 Peptidase C1-like family Arf PF00025.16 ESL07634.1 - 4e-42 143.4 0.0 4.5e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ESL07634.1 - 1.3e-16 60.4 0.0 1.5e-16 60.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL07634.1 - 1.1e-11 45.2 0.0 2.9e-11 43.9 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL07634.1 - 5.2e-08 32.3 0.0 5.7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESL07634.1 - 2.2e-07 30.2 0.0 2.7e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL07634.1 - 1e-06 28.6 0.0 1.5e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 ESL07634.1 - 3.5e-05 22.6 0.2 0.00016 20.5 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.22 ESL07634.1 - 0.00058 19.3 0.0 0.014 14.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain NACHT PF05729.7 ESL07634.1 - 0.00059 19.5 0.4 0.016 14.9 0.3 2.1 1 1 0 1 1 1 1 NACHT domain AAA_29 PF13555.1 ESL07634.1 - 0.0081 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain cobW PF02492.14 ESL07634.1 - 0.0084 15.5 0.0 0.13 11.6 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 ESL07634.1 - 0.0093 16.2 0.0 0.011 15.9 0.0 1.3 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.1 ESL07634.1 - 0.018 14.9 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 ESL07634.1 - 0.032 13.7 0.0 1.9 7.9 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SRP54 PF00448.17 ESL07634.1 - 0.038 13.4 0.1 0.059 12.8 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain FeoB_N PF02421.13 ESL07634.1 - 0.049 12.9 0.1 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_23 PF13476.1 ESL07634.1 - 0.064 13.5 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ribosom_S12_S23 PF00164.20 ESL07635.1 - 4.5e-39 132.6 0.6 6e-39 132.2 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ATG27 PF09451.5 ESL07637.1 - 0.0074 15.5 0.1 0.0095 15.1 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 DUF4013 PF13197.1 ESL07637.1 - 0.037 13.3 1.6 0.049 12.9 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) ATG27 PF09451.5 ESL07638.1 - 1.5e-05 24.4 0.0 2.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 Pox_TAP PF03355.9 ESL07640.1 - 0.15 11.3 0.1 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Viral Trans-Activator Protein Glyco_transf_28 PF03033.15 ESL07641.1 - 0.032 13.9 0.1 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Helicase_C PF00271.26 ESL07642.1 - 1.5e-08 34.3 0.0 4.1e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL07642.1 - 3.6e-06 26.5 0.1 1.1e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF914 PF06027.7 ESL07643.1 - 5.5e-48 163.5 3.7 6.8e-48 163.2 2.6 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 ESL07643.1 - 0.00032 20.7 8.9 0.00049 20.1 5.9 1.5 1 1 0 1 1 1 1 EamA-like transporter family UAA PF08449.6 ESL07643.1 - 0.0012 17.8 1.8 0.0018 17.2 1.2 1.3 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 ESL07643.1 - 0.0013 18.8 6.0 0.0013 18.8 4.1 1.7 2 0 0 2 2 2 1 Multidrug resistance efflux transporter Mg_trans_NIPA PF05653.9 ESL07643.1 - 0.002 17.1 2.7 0.002 17.1 1.9 1.7 1 1 1 2 2 2 1 Magnesium transporter NIPA TPT PF03151.11 ESL07643.1 - 0.03 13.9 7.6 0.093 12.3 4.2 2.2 2 1 0 2 2 2 0 Triose-phosphate Transporter family FUSC-like PF12805.2 ESL07643.1 - 0.046 12.6 0.2 0.089 11.7 0.1 1.4 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS MTS PF05175.9 ESL07644.1 - 0.00019 20.8 0.2 0.00052 19.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESL07644.1 - 0.00033 20.9 0.1 0.014 15.7 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL07644.1 - 0.0039 17.6 0.0 0.012 16.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL07644.1 - 0.0082 16.1 0.7 0.019 14.9 0.5 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL07644.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 ESL07644.1 - 0.027 15.0 0.0 0.056 14.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESL07644.1 - 0.046 14.2 0.0 0.14 12.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ESL07644.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CIAPIN1 PF05093.8 ESL07645.1 - 4.4e-17 62.0 16.7 1.1e-15 57.5 11.6 2.1 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis TTL PF03133.10 ESL07647.1 - 1.9e-44 151.7 0.0 2.8e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Pribosyltran PF00156.22 ESL07648.1 - 3.4e-11 42.9 0.0 7.3e-11 41.8 0.0 1.5 2 0 0 2 2 2 1 Phosphoribosyl transferase domain RRM_1 PF00076.17 ESL07650.1 - 2e-31 107.3 0.0 6.3e-20 70.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL07650.1 - 1.2e-23 82.8 0.0 3.4e-12 46.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07650.1 - 2.1e-10 40.2 0.0 8.9e-07 28.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESL07650.1 - 0.00026 20.6 0.0 0.00093 18.9 0.0 2.0 1 1 0 1 1 1 1 Limkain b1 RNA_bind PF08675.6 ESL07650.1 - 0.0023 17.9 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 2 RNA binding domain FAD_binding_6 PF00970.19 ESL07651.1 - 1.7e-06 28.0 0.0 2.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESL07651.1 - 3.9e-06 27.4 0.0 1.1e-05 25.9 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain C2 PF00168.25 ESL07653.1 - 2.3e-19 69.0 0.0 9.8e-06 25.3 0.0 4.4 4 0 0 4 4 4 4 C2 domain DUF1978 PF09321.5 ESL07653.1 - 0.95 8.8 7.8 2.5 7.4 5.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1978) zf-RING_2 PF13639.1 ESL07654.1 - 3.9e-16 58.6 21.5 1.5e-08 34.3 6.7 3.2 3 0 0 3 3 3 2 Ring finger domain zf-RING_5 PF14634.1 ESL07654.1 - 6e-09 35.4 21.6 5.2e-05 22.8 6.4 3.3 3 0 0 3 3 3 2 zinc-RING finger domain zf-rbx1 PF12678.2 ESL07654.1 - 3.7e-07 30.1 15.0 0.00057 19.9 4.2 3.5 3 1 1 4 4 4 2 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESL07654.1 - 4.8e-06 26.1 21.2 0.0057 16.3 6.1 3.3 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL07654.1 - 1.7e-05 24.7 20.7 0.019 15.0 0.8 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) IQ PF00612.22 ESL07654.1 - 3.6e-05 23.0 3.1 0.00013 21.2 2.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Rtf2 PF04641.7 ESL07654.1 - 0.014 14.5 9.6 2.3 7.3 2.5 3.2 2 1 1 3 3 3 0 Rtf2 RING-finger zf-C3HC4 PF00097.20 ESL07654.1 - 0.043 13.4 23.9 0.29 10.8 6.4 3.8 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL07654.1 - 0.073 12.9 15.8 0.61 9.9 0.5 3.6 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn-ribbon_8 PF09723.5 ESL07654.1 - 0.42 10.5 12.1 0.12 12.3 0.6 3.8 3 1 0 3 3 3 0 Zinc ribbon domain FANCL_C PF11793.3 ESL07654.1 - 0.48 10.4 16.7 0.37 10.7 0.3 3.2 3 0 0 3 3 3 0 FANCL C-terminal domain RRM_6 PF14259.1 ESL07655.1 - 8.2e-17 60.9 0.2 5.4e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL07655.1 - 2e-14 52.9 1.0 5.3e-06 25.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL07655.1 - 9.1e-09 35.0 1.0 2.1e-05 24.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 ESL07657.1 - 5.2e-30 102.2 2.5 1.9e-06 27.5 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 ESL07657.1 - 0.035 12.2 2.8 0.12 10.5 0.3 2.6 1 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF4205 PF13898.1 ESL07660.1 - 7.7e-26 90.6 0.0 1.3e-25 89.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) MutS_V PF00488.16 ESL07661.1 - 3.6e-42 144.3 0.0 6.3e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESL07661.1 - 5.4e-21 75.3 0.2 1.1e-20 74.2 0.1 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 ESL07661.1 - 7.4e-06 26.0 0.1 3e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 MutS family domain IV AAA_22 PF13401.1 ESL07661.1 - 0.0022 18.1 0.2 0.019 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESL07661.1 - 0.012 15.5 1.5 0.041 13.8 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 ESL07661.1 - 0.02 14.6 2.0 0.087 12.5 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain AAA_29 PF13555.1 ESL07661.1 - 0.051 13.1 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 ESL07661.1 - 0.06 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESL07661.1 - 0.097 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 ESL07661.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESL07661.1 - 0.28 10.8 0.0 0.63 9.6 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_21 PF13304.1 ESL07661.1 - 0.44 10.4 0.0 0.71 9.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sec23_trunk PF04811.10 ESL07662.1 - 5.2e-39 134.0 0.0 8.4e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.10 ESL07662.1 - 3.1e-17 61.8 6.3 7.1e-17 60.6 4.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 ESL07662.1 - 2.6e-16 59.8 0.0 6.7e-16 58.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.10 ESL07662.1 - 5.5e-13 48.2 0.0 3.9e-12 45.4 0.0 2.4 2 0 0 2 2 2 1 Sec23/Sec24 helical domain TFIIA PF03153.8 ESL07662.1 - 9.1 6.0 14.1 12 5.6 9.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Thrombin_light PF09396.5 ESL07664.1 - 0.079 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Thrombin light chain ABC_tran_2 PF12848.2 ESL07665.1 - 4.4 7.2 13.7 0.71 9.7 5.9 2.4 2 1 0 2 2 2 0 ABC transporter ATP-grasp_4 PF13535.1 ESL07666.1 - 4.6e-10 39.5 0.1 1.1e-09 38.2 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESL07666.1 - 5.7e-07 29.1 0.0 8.2e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 ESL07666.1 - 0.00013 21.3 0.0 0.00021 20.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESL07666.1 - 0.024 13.3 0.0 0.05 12.3 0.0 1.5 1 1 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.14 ESL07666.1 - 0.072 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PLAC8 PF04749.12 ESL07667.1 - 0.0056 17.2 30.8 0.0056 17.2 21.4 1.4 2 0 0 2 2 2 1 PLAC8 family FERM_M PF00373.13 ESL07668.1 - 7.4e-18 64.9 0.0 1.3e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 FERM central domain LRR_1 PF00560.28 ESL07668.1 - 9.5e-12 43.2 0.7 18 5.8 0.0 8.9 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.2 ESL07668.1 - 3.2e-11 42.5 0.0 0.15 11.7 0.0 5.8 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL07668.1 - 6.6e-11 41.1 2.3 3.6 7.9 0.0 8.4 9 0 0 9 9 9 2 Leucine Rich repeat FERM_N PF09379.5 ESL07668.1 - 4.5e-08 33.0 0.0 8e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 FERM N-terminal domain LRR_7 PF13504.1 ESL07668.1 - 1.2e-07 30.7 6.1 21 5.9 0.0 9.1 10 0 0 10 10 10 1 Leucine rich repeat LRR_8 PF13855.1 ESL07668.1 - 0.0027 17.4 5.0 1 9.1 0.1 4.8 3 2 2 5 5 5 2 Leucine rich repeat WD40 PF00400.27 ESL07672.1 - 6e-07 29.1 10.9 0.084 12.7 0.1 5.6 4 1 0 4 4 4 3 WD domain, G-beta repeat ATP-synt_F PF01990.12 ESL07673.1 - 5.9e-31 106.7 0.2 8.5e-31 106.2 0.1 1.3 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Phage_glycop_gL PF11108.3 ESL07674.1 - 1.4 8.9 4.6 4.8 7.2 2.1 2.7 2 1 0 2 2 2 0 Viral glycoprotein L TPR_12 PF13424.1 ESL07675.1 - 1.6e-11 44.0 15.9 2.2e-06 27.4 0.8 5.1 3 2 1 5 5 5 3 Tetratricopeptide repeat DUF2743 PF10899.3 ESL07675.1 - 0.0021 17.4 0.1 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2743) TPR_11 PF13414.1 ESL07675.1 - 0.3 10.7 17.8 0.42 10.3 1.2 4.5 4 0 0 4 4 4 0 TPR repeat Apc5 PF12862.2 ESL07675.1 - 0.69 9.7 6.7 1.9 8.4 0.5 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_1 PF00515.23 ESL07675.1 - 0.7 9.6 7.8 5.6 6.7 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.16 ESL07676.1 - 2.7e-17 62.7 0.0 2.9e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pox_vIL-18BP PF05566.7 ESL07676.1 - 0.026 14.5 0.0 0.032 14.2 0.0 1.1 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein Reo_sigmaC PF04582.7 ESL07677.1 - 0.041 13.0 0.5 0.074 12.2 0.3 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein OmpH PF03938.9 ESL07677.1 - 0.82 9.5 7.4 1.3 8.9 5.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4129 PF13559.1 ESL07679.1 - 0.0013 18.6 0.7 0.0053 16.6 0.5 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) Pex19 PF04614.7 ESL07680.1 - 1.1e-13 51.3 0.1 3.7e-13 49.6 0.1 1.7 1 1 0 1 1 1 1 Pex19 protein family Leader_Thr PF08254.6 ESL07680.1 - 0.21 11.3 0.4 0.21 11.3 0.3 2.1 2 0 0 2 2 2 0 Threonine leader peptide TPR_MLP1_2 PF07926.7 ESL07681.1 - 8.4e-05 22.3 0.0 0.26 11.0 0.0 2.3 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Sugarporin_N PF11471.3 ESL07681.1 - 0.00015 21.3 3.9 0.011 15.3 0.1 2.9 2 1 0 2 2 2 2 Maltoporin periplasmic N-terminal extension HisKA_3 PF07730.8 ESL07681.1 - 0.008 16.5 3.1 1.3 9.4 0.0 3.1 4 0 0 4 4 4 1 Histidine kinase CENP-F_leu_zip PF10473.4 ESL07681.1 - 0.053 13.3 17.4 0.036 13.9 8.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FAM104 PF15434.1 ESL07681.1 - 0.14 12.3 1.4 0.24 11.6 0.0 2.0 2 1 0 2 2 2 0 Family 104 ACCA PF03255.9 ESL07681.1 - 0.14 11.7 4.2 0.14 11.6 1.2 2.0 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit WD40_alt PF14077.1 ESL07681.1 - 0.14 11.7 10.2 2.9 7.6 0.1 3.6 4 0 0 4 4 4 0 Alternative WD40 repeat motif AKNA PF12443.3 ESL07681.1 - 0.26 11.2 5.9 0.44 10.5 0.4 2.8 2 1 0 2 2 2 0 AT-hook-containing transcription factor ADIP PF11559.3 ESL07681.1 - 0.31 10.9 12.2 0.28 11.0 5.0 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4164 PF13747.1 ESL07681.1 - 0.37 10.9 10.1 0.12 12.4 1.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) APG6 PF04111.7 ESL07681.1 - 0.49 9.3 8.0 0.053 12.5 2.5 1.5 2 0 0 2 2 2 0 Autophagy protein Apg6 DivIC PF04977.10 ESL07681.1 - 0.97 8.9 9.5 3.6 7.1 0.7 3.2 2 1 1 3 3 3 0 Septum formation initiator DUF972 PF06156.8 ESL07681.1 - 7.3 6.9 12.2 18 5.7 3.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Med21 PF11221.3 ESL07681.1 - 8.1 6.4 9.4 2.4 8.1 1.5 2.6 2 1 0 2 2 2 0 Subunit 21 of Mediator complex DSPc PF00782.15 ESL07682.1 - 4.4e-31 107.2 0.0 7.6e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.1 ESL07682.1 - 1.4e-10 40.7 3.0 2.2e-05 24.0 1.5 3.5 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.2 ESL07682.1 - 2.8e-09 36.3 7.0 9.5e-05 21.9 0.6 3.2 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL07682.1 - 1.4e-06 27.5 7.7 0.057 13.4 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 ESL07682.1 - 0.0001 21.9 4.0 0.94 9.9 0.1 4.7 5 0 0 5 5 5 2 Leucine rich repeat Y_phosphatase PF00102.22 ESL07682.1 - 0.00041 19.7 0.0 0.00058 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_6 PF13516.1 ESL07682.1 - 0.014 15.3 2.3 10 6.5 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich repeat CDKN3 PF05706.7 ESL07682.1 - 0.04 13.3 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) RNB PF00773.14 ESL07683.1 - 1e-92 310.9 0.6 1.7e-92 310.1 0.4 1.3 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 ESL07683.1 - 3.5e-08 33.6 0.1 9.1e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 PIN domain His_Phos_1 PF00300.17 ESL07684.1 - 1.6e-28 99.8 0.0 2e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 ESL07684.1 - 0.046 13.0 0.0 0.1 11.8 0.0 1.5 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Mob1_phocein PF03637.12 ESL07685.1 - 9e-62 207.8 0.1 1.1e-61 207.5 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Tcp11 PF05794.8 ESL07686.1 - 7.7e-23 80.9 0.0 2.4e-22 79.3 0.0 1.8 1 1 0 1 1 1 1 T-complex protein 11 HAND PF09110.6 ESL07686.1 - 0.0077 16.6 1.3 0.025 14.9 0.9 1.8 1 0 0 1 1 1 1 HAND p25-alpha PF05517.7 ESL07687.1 - 4.4e-47 160.1 1.9 5.7e-47 159.8 1.3 1.1 1 0 0 1 1 1 1 p25-alpha Kinesin PF00225.18 ESL07688.1 - 7e-09 34.8 0.0 0.00037 19.2 0.0 2.6 2 0 0 2 2 2 2 Kinesin motor domain Mnd1 PF03962.10 ESL07688.1 - 0.35 10.4 24.8 0.12 11.9 7.7 2.6 1 1 2 3 3 3 0 Mnd1 family Spc7 PF08317.6 ESL07689.1 - 0.00077 18.2 2.0 0.0015 17.2 1.4 1.6 1 0 0 1 1 1 1 Spc7 kinetochore protein PDZ_2 PF13180.1 ESL07689.1 - 0.00085 19.1 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain MutS_III PF05192.13 ESL07689.1 - 0.0052 16.5 0.1 0.0091 15.7 0.1 1.5 1 0 0 1 1 1 1 MutS domain III PDZ PF00595.19 ESL07689.1 - 0.015 15.4 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) IncA PF04156.9 ESL07689.1 - 0.43 10.1 7.8 0.091 12.3 2.0 2.2 2 0 0 2 2 2 0 IncA protein Mnd1 PF03962.10 ESL07689.1 - 1.1 8.9 9.5 0.1 12.2 3.0 1.9 2 0 0 2 2 2 0 Mnd1 family MOZ_SAS PF01853.13 ESL07690.1 - 3.6e-37 127.4 0.5 6.7e-36 123.2 0.4 2.2 1 1 0 1 1 1 1 MOZ/SAS family MOZ_SAS PF01853.13 ESL07691.1 - 4.2e-61 205.4 0.0 6.6e-61 204.8 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 ESL07691.1 - 8.7e-09 34.9 0.1 2e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.19 ESL07691.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family zf-C2H2_4 PF13894.1 ESL07691.1 - 0.075 13.4 2.8 0.26 11.7 1.9 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger Sulfolobus_pRN PF05584.6 ESL07691.1 - 0.09 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein zf-C2H2 PF00096.21 ESL07691.1 - 0.17 12.2 2.2 0.49 10.8 1.5 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type MAGE_N PF12440.3 ESL07692.1 - 0.11 12.7 0.6 0.23 11.7 0.4 1.5 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal SRP54 PF00448.17 ESL07693.1 - 1.6e-72 243.1 0.8 1.6e-72 243.1 0.5 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 ESL07693.1 - 9.2e-27 93.3 1.9 9.2e-27 93.3 1.3 3.9 2 1 2 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.14 ESL07693.1 - 3.1e-13 49.6 0.5 8.7e-13 48.1 0.3 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 ESL07693.1 - 1.1e-07 31.4 0.1 3.5e-07 29.8 0.1 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 ESL07693.1 - 2.2e-06 27.5 0.1 5.3e-06 26.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain CbiA PF01656.18 ESL07693.1 - 1e-05 25.0 0.1 3.9e-05 23.1 0.1 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 ESL07693.1 - 5.3e-05 22.9 0.4 0.00052 19.7 0.1 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 ESL07693.1 - 5.7e-05 23.2 0.7 0.0014 18.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain ArgK PF03308.11 ESL07693.1 - 0.00011 21.1 1.6 0.0084 14.9 0.1 3.1 2 1 1 3 3 3 1 ArgK protein Zeta_toxin PF06414.7 ESL07693.1 - 0.00076 18.6 0.0 0.0018 17.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_31 PF13614.1 ESL07693.1 - 0.00097 19.1 0.0 2.3 8.1 0.0 3.1 3 0 0 3 3 3 2 AAA domain Methyltransf_24 PF13578.1 ESL07693.1 - 0.0038 18.0 0.0 0.01 16.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain AAA_16 PF13191.1 ESL07693.1 - 0.0039 17.2 0.0 0.0077 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.1 ESL07693.1 - 0.0052 16.3 0.1 0.017 14.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.15 ESL07693.1 - 0.0058 16.3 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_17 PF13207.1 ESL07693.1 - 0.012 16.4 0.0 0.024 15.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESL07693.1 - 0.018 15.2 0.5 0.17 12.0 0.1 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESL07693.1 - 0.018 14.4 0.0 0.068 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 ESL07693.1 - 0.024 14.1 0.2 0.11 12.0 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SRPRB PF09439.5 ESL07693.1 - 0.026 13.7 0.7 4.2 6.5 0.1 2.5 1 1 0 2 2 2 0 Signal recognition particle receptor beta subunit ATP-cone PF03477.11 ESL07693.1 - 0.064 13.6 0.9 0.19 12.2 0.1 2.1 2 0 0 2 2 1 0 ATP cone domain SWIB PF02201.13 ESL07693.1 - 0.14 11.8 0.8 0.51 10.0 0.1 2.3 2 0 0 2 2 2 0 SWIB/MDM2 domain NTPase_1 PF03266.10 ESL07693.1 - 3.9 7.1 6.4 12 5.5 1.2 2.9 2 1 0 2 2 2 0 NTPase DUF3613 PF12266.3 ESL07695.1 - 0.0026 17.2 0.0 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3613) zf-rbx1 PF12678.2 ESL07696.1 - 2e-22 79.0 13.4 3.4e-14 52.6 2.1 2.4 2 0 0 2 2 2 2 RING-H2 zinc finger zf-Apc11 PF12861.2 ESL07696.1 - 2.2e-11 43.4 16.5 2.1e-09 37.1 1.8 2.5 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 ESL07696.1 - 4.8e-09 35.9 4.6 4.8e-09 35.9 3.2 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL07696.1 - 0.0011 18.9 7.4 0.0011 18.9 5.2 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL07696.1 - 0.0017 18.0 2.4 0.0017 18.0 1.7 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL07696.1 - 0.0024 17.5 3.2 0.0024 17.5 2.2 2.9 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL07696.1 - 0.0031 17.1 4.6 0.0031 17.1 3.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DiS_P_DiS PF06750.8 ESL07696.1 - 0.026 14.3 0.3 0.026 14.3 0.2 2.1 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain FANCL_C PF11793.3 ESL07696.1 - 0.15 12.0 8.7 3.7 7.5 2.6 3.1 2 1 1 3 3 3 0 FANCL C-terminal domain zf-Nse PF11789.3 ESL07696.1 - 0.37 10.3 6.0 0.14 11.7 1.6 2.2 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESL07696.1 - 1.3 8.7 8.7 1.3 8.8 1.6 3.3 3 1 0 3 3 3 0 RING-type zinc-finger SRPRB PF09439.5 ESL07697.1 - 2.6e-25 88.6 0.1 7.2e-24 83.9 0.1 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 ESL07697.1 - 4.2e-09 36.1 0.0 5e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 ESL07697.1 - 5e-08 32.3 0.0 1.2e-06 27.8 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESL07697.1 - 7.5e-06 25.8 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL07697.1 - 0.00046 20.6 0.0 0.0009 19.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein AAA_33 PF13671.1 ESL07697.1 - 0.00061 19.6 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 ESL07697.1 - 0.00085 18.8 0.2 0.033 13.6 0.1 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NAD_binding_3 PF03447.11 ESL07697.1 - 0.015 15.6 0.6 0.085 13.2 0.1 2.0 1 1 1 2 2 2 0 Homoserine dehydrogenase, NAD binding domain DUF258 PF03193.11 ESL07697.1 - 0.023 13.8 0.1 0.06 12.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 cobW PF02492.14 ESL07697.1 - 0.024 14.0 0.1 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 ESL07697.1 - 0.029 14.0 0.7 1 8.9 0.1 2.2 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.1 ESL07697.1 - 0.033 14.1 1.9 0.25 11.2 1.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.13 ESL07697.1 - 0.043 12.8 0.0 0.066 12.2 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_22 PF13401.1 ESL07697.1 - 0.051 13.7 0.0 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESL07697.1 - 0.072 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP_bind_1 PF03029.12 ESL07697.1 - 0.085 12.3 0.8 5.4 6.4 0.2 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.4 ESL07697.1 - 0.09 12.2 0.1 0.82 9.1 0.0 2.3 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 ESL07697.1 - 0.13 11.9 0.1 0.29 10.8 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 ESL07697.1 - 0.13 11.3 0.0 0.31 10.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.1 ESL07697.1 - 0.27 10.7 0.0 0.27 10.7 0.0 1.9 2 0 0 2 2 1 0 P-loop containing region of AAA domain RabGAP-TBC PF00566.13 ESL07698.1 - 4.4e-07 29.6 0.1 1.1e-06 28.2 0.1 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1507 PF07408.6 ESL07698.1 - 0.035 13.8 0.0 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1507) GTP_EFTU PF00009.22 ESL07699.1 - 7.4e-35 120.0 0.0 1.5e-34 119.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 ESL07699.1 - 1e-28 99.2 0.2 2.6e-28 97.8 0.1 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 ESL07699.1 - 7.1e-05 22.8 0.3 0.00066 19.7 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Zn-ribbon_8 PF09723.5 ESL07699.1 - 0.0002 21.2 1.2 0.0005 19.9 0.9 1.7 1 0 0 1 1 1 1 Zinc ribbon domain MMR_HSR1 PF01926.18 ESL07699.1 - 0.00035 20.4 0.0 0.00085 19.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 ESL07699.1 - 0.056 12.6 0.2 0.35 10.0 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family Dynamin_N PF00350.18 ESL07699.1 - 0.069 12.9 0.1 0.42 10.3 0.0 2.3 2 0 0 2 2 2 0 Dynamin family DZR PF12773.2 ESL07699.1 - 0.68 9.7 3.8 0.92 9.3 1.5 1.9 2 0 0 2 2 2 0 Double zinc ribbon zf-C4_Topoisom PF01396.14 ESL07699.1 - 1 8.9 4.0 0.31 10.5 0.2 2.0 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Pkinase PF00069.20 ESL07700.1 - 2.6e-45 154.6 0.0 5.4e-40 137.1 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07700.1 - 2.5e-12 46.4 0.0 1e-09 37.8 0.0 3.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 ESL07700.1 - 0.00032 19.8 0.1 0.0006 18.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL07700.1 - 0.0061 15.5 0.0 0.095 11.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESL07700.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Vps39_2 PF10367.4 ESL07701.1 - 1.2e-22 80.0 0.2 2.8e-22 78.9 0.2 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 ESL07701.1 - 7.3e-06 25.6 0.0 0.14 11.7 0.0 2.9 3 0 0 3 3 3 2 Region in Clathrin and VPS MFS_1 PF07690.11 ESL07702.1 - 1.9e-14 53.1 33.9 1.9e-14 53.1 23.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESL07702.1 - 8.6e-06 24.5 10.1 8.6e-06 24.5 7.0 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter Beta_helix PF13229.1 ESL07704.1 - 0.0021 17.8 9.4 0.029 14.1 0.1 5.0 5 2 2 7 7 7 2 Right handed beta helix region NAD_binding_10 PF13460.1 ESL07705.1 - 9.9e-17 61.5 0.1 1.6e-16 60.8 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESL07705.1 - 8e-07 28.7 0.1 3.9e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 ESL07705.1 - 0.026 13.7 0.0 0.12 11.5 0.0 2.1 3 0 0 3 3 3 0 NmrA-like family Pkinase PF00069.20 ESL07706.1 - 1.9e-45 155.0 0.0 5.8e-45 153.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07706.1 - 1.8e-16 60.0 0.0 1.9e-14 53.3 0.0 2.9 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07706.1 - 3.9e-08 32.5 0.0 6.2e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL07706.1 - 0.016 14.9 0.0 0.016 14.9 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESL07706.1 - 0.025 14.1 0.1 0.42 10.1 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.20 ESL07707.1 - 1.6e-58 197.9 0.0 2.2e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07707.1 - 9.1e-31 106.8 0.0 1.4e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_6 PF13405.1 ESL07707.1 - 5.7e-05 22.6 0.7 0.72 9.8 0.1 3.6 2 1 1 3 3 3 2 EF-hand domain Kinase-like PF14531.1 ESL07707.1 - 0.0049 15.8 0.0 0.14 11.0 0.0 2.5 2 1 0 2 2 2 1 Kinase-like EF-hand_7 PF13499.1 ESL07707.1 - 0.041 14.0 0.2 2.4 8.3 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair Kdo PF06293.9 ESL07707.1 - 0.057 12.4 0.0 0.17 10.8 0.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESL07707.1 - 0.12 11.7 0.0 0.56 9.5 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Methyltransf_23 PF13489.1 ESL07708.1 - 3.8e-22 78.7 0.0 6.5e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL07708.1 - 8.1e-18 64.4 0.0 3.3e-17 62.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL07708.1 - 3e-17 62.8 0.0 6.1e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL07708.1 - 7.5e-13 48.8 0.0 2e-12 47.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL07708.1 - 2.7e-12 47.2 0.1 4.4e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESL07708.1 - 5.7e-11 42.0 0.0 8e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 ESL07708.1 - 1.2e-08 35.0 0.0 2.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESL07708.1 - 1.6e-07 30.7 0.0 2.1e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 ESL07708.1 - 4.8e-07 30.0 0.1 1.1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESL07708.1 - 2.8e-06 26.8 0.1 4.3e-05 22.9 0.1 2.0 1 1 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.1 ESL07708.1 - 7.2e-06 25.7 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESL07708.1 - 1.1e-05 24.6 0.0 4.4e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.9 ESL07708.1 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 ESL07708.1 - 0.00015 21.3 0.0 0.00022 20.8 0.0 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pox_MCEL PF03291.11 ESL07708.1 - 0.0015 17.4 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme MetW PF07021.7 ESL07708.1 - 0.0083 15.5 1.3 0.044 13.1 0.9 2.1 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.6 ESL07708.1 - 0.018 13.7 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) TPMT PF05724.6 ESL07708.1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Ubie_methyltran PF01209.13 ESL07708.1 - 0.025 13.6 0.0 0.055 12.5 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family RrnaAD PF00398.15 ESL07708.1 - 0.038 13.0 0.0 0.051 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase WD40 PF00400.27 ESL07709.1 - 1.4e-07 31.0 0.1 1.4e-07 31.0 0.1 4.8 5 1 0 5 5 5 1 WD domain, G-beta repeat eIF2A PF08662.6 ESL07709.1 - 0.016 14.9 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Me-amine-dh_H PF06433.6 ESL07709.1 - 0.066 11.8 0.0 0.61 8.6 0.0 2.0 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.3 ESL07709.1 - 0.079 11.0 2.3 0.15 10.1 1.6 1.5 1 1 0 1 1 1 0 Nucleoporin Nup120/160 DNA_pol_A_exo1 PF01612.15 ESL07711.1 - 1.1e-10 41.2 0.0 2.5e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease Synaptobrevin PF00957.16 ESL07712.1 - 2.5e-15 55.8 0.3 4.8e-15 54.9 0.2 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 ESL07712.1 - 5.3e-13 48.3 0.0 8.5e-13 47.6 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Ank PF00023.25 ESL07713.1 - 4e-27 92.6 5.0 1e-09 37.7 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.2 ESL07713.1 - 1.5e-25 89.2 2.8 6.2e-14 52.1 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESL07713.1 - 1.4e-23 82.3 6.0 7.6e-09 35.5 0.8 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESL07713.1 - 1.7e-22 79.3 5.8 1.5e-09 38.1 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL07713.1 - 8e-19 65.8 1.6 1.4e-05 24.8 0.0 4.0 5 0 0 5 5 5 3 Ankyrin repeat PIP49_N PF14875.1 ESL07713.1 - 0.024 14.3 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 NAD_binding_10 PF13460.1 ESL07714.1 - 5.4e-11 42.8 0.0 0.00011 22.3 0.0 2.2 1 1 1 2 2 2 2 NADH(P)-binding 3Beta_HSD PF01073.14 ESL07714.1 - 9.4e-07 27.7 0.0 5e-06 25.4 0.0 1.9 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 ESL07714.1 - 0.00033 20.0 0.1 0.0013 18.0 0.1 1.8 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 ESL07714.1 - 0.0067 15.8 0.0 0.061 12.7 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 ESL07714.1 - 0.039 14.3 0.0 0.082 13.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.20 ESL07714.1 - 0.086 12.7 0.4 1.3 8.9 0.1 2.3 1 1 1 2 2 2 0 short chain dehydrogenase NAD_binding_4 PF07993.7 ESL07714.1 - 0.11 11.4 0.1 0.2 10.5 0.1 1.6 1 1 0 1 1 1 0 Male sterility protein TPR_2 PF07719.12 ESL07715.1 - 0.00032 20.4 0.0 0.00077 19.1 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07715.1 - 0.0061 16.1 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TctB PF07331.6 ESL07715.1 - 0.017 14.7 0.0 0.017 14.7 0.0 2.2 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family HemY_N PF07219.8 ESL07715.1 - 0.064 12.8 1.0 0.2 11.2 0.0 2.1 2 0 0 2 2 2 0 HemY protein N-terminus TPR_11 PF13414.1 ESL07715.1 - 0.082 12.5 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 TPR repeat TPR_8 PF13181.1 ESL07715.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07715.1 - 0.15 12.7 0.1 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Ribosomal_L10 PF00466.15 ESL07716.1 - 0.077 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L10 Glycos_transf_2 PF00535.21 ESL07717.1 - 1.4e-31 109.4 0.0 1.7e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESL07717.1 - 1.3e-11 44.7 0.0 1.7e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESL07717.1 - 3e-05 23.2 0.0 3.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 ESL07717.1 - 0.00047 19.5 0.0 0.00086 18.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 ESL07717.1 - 0.05 13.9 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 ESL07717.1 - 0.09 12.4 2.6 0.23 11.1 0.0 2.2 1 1 1 2 2 2 0 Glycosyl transferase family group 2 RHH_4 PF13467.1 ESL07719.1 - 0.037 13.8 0.1 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix domain Alpha-2-MRAP_C PF06401.6 ESL07719.1 - 0.092 12.5 6.5 0.11 12.3 4.5 1.1 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain ICEA PF05315.6 ESL07719.1 - 0.28 10.4 2.5 0.36 10.0 1.8 1.1 1 0 0 1 1 1 0 ICEA Protein APO_RNA-bind PF05634.6 ESL07719.1 - 0.6 9.2 6.5 0.36 9.9 3.0 1.7 1 1 1 2 2 2 0 APO RNA-binding DUF883 PF05957.8 ESL07719.1 - 1.1 9.7 8.0 0.13 12.6 0.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DMPK_coil PF08826.5 ESL07719.1 - 2.3 8.1 9.6 3.4 7.6 0.2 2.4 1 1 1 2 2 2 0 DMPK coiled coil domain like HWE_HK PF07536.9 ESL07720.1 - 0.023 15.1 0.3 0.051 14.0 0.2 1.5 1 0 0 1 1 1 0 HWE histidine kinase Abi_C PF14355.1 ESL07720.1 - 0.032 14.1 0.1 0.13 12.1 0.0 2.1 2 1 0 2 2 2 0 Abortive infection C-terminus Peptidase_M8 PF01457.11 ESL07722.1 - 2.4e-76 257.1 0.0 2.9e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESL07722.1 - 0.0029 17.5 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M57 PF12388.3 ESL07722.1 - 0.0051 16.1 0.0 0.0079 15.5 0.0 1.2 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.1 ESL07722.1 - 0.017 15.6 0.0 0.026 15.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.19 ESL07722.1 - 0.019 14.3 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.1 ESL07722.1 - 0.064 13.3 0.1 0.095 12.7 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 ESL07722.1 - 0.14 11.6 0.0 1 8.8 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like RNA_pol_N PF01194.12 ESL07723.1 - 1.4e-25 89.0 0.3 1.6e-25 88.8 0.2 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.7 ESL07723.1 - 0.14 12.2 0.8 0.28 11.2 0.5 1.5 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Phage_int_SAM_4 PF13495.1 ESL07724.1 - 0.065 13.5 0.3 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Choline_transpo PF04515.7 ESL07727.1 - 1.3e-51 175.2 38.5 1.3e-51 175.2 26.7 2.7 3 0 0 3 3 3 2 Plasma-membrane choline transporter tRNA_edit PF04073.10 ESL07728.1 - 7.6e-08 32.2 0.0 2.7e-07 30.4 0.0 1.8 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain Ran_BP1 PF00638.13 ESL07729.1 - 6.5e-28 97.2 0.4 8.6e-28 96.8 0.3 1.1 1 0 0 1 1 1 1 RanBP1 domain PDDEXK_1 PF12705.2 ESL07730.1 - 0.068 12.5 4.4 0.12 11.7 3.1 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Oxygenase-NA PF09859.4 ESL07730.1 - 0.12 11.6 1.9 3 7.1 0.7 2.2 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA DUF2205 PF10224.4 ESL07731.1 - 0.016 14.7 1.2 0.016 14.7 0.8 2.8 3 1 1 4 4 4 0 Predicted coiled-coil protein (DUF2205) LTXXQ PF07813.7 ESL07731.1 - 0.023 15.1 7.5 0.051 14.0 5.2 1.5 1 0 0 1 1 1 0 LTXXQ motif family protein DUF724 PF05266.9 ESL07731.1 - 0.67 9.5 5.9 1.4 8.5 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) GTP_EFTU PF00009.22 ESL07732.1 - 5.2e-55 185.8 0.0 6.2e-55 185.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL07732.1 - 1.4e-05 25.0 0.0 0.00031 20.6 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL07732.1 - 0.0016 18.9 0.2 0.05 14.1 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL07732.1 - 0.014 14.5 0.0 0.037 13.1 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 ESL07732.1 - 0.086 12.6 0.0 13 5.5 0.0 2.3 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.13 ESL07732.1 - 0.087 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Pox_MCEL PF03291.11 ESL07733.1 - 1.1e-06 27.8 0.0 1.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.1 ESL07733.1 - 2.3e-05 24.6 0.0 9.5e-05 22.6 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain mRNA_cap_enzyme PF01331.14 ESL07733.1 - 0.022 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain Radial_spoke PF04712.7 ESL07735.1 - 7.2e-06 25.0 0.0 0.0031 16.3 0.0 2.7 2 1 0 2 2 2 2 Radial spokehead-like protein Ribosomal_L11_N PF03946.9 ESL07736.1 - 3.1e-15 55.3 0.3 5.5e-15 54.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 ESL07736.1 - 4.7e-10 39.4 0.5 8.6e-10 38.6 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Pkinase PF00069.20 ESL07737.1 - 1.6e-35 122.5 0.0 3.9e-35 121.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07737.1 - 2.3e-20 72.7 0.0 2.9e-19 69.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL07737.1 - 0.0009 18.2 0.0 0.015 14.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like LRR_6 PF13516.1 ESL07738.1 - 8.4e-17 59.3 11.9 0.0065 16.4 0.0 10.3 11 0 0 11 11 11 3 Leucine Rich repeat LRR_4 PF12799.2 ESL07738.1 - 5.9e-09 35.3 6.1 0.56 9.9 0.0 6.5 5 2 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL07738.1 - 0.00047 19.8 6.9 0.77 9.5 0.0 4.9 5 2 0 5 5 5 2 Leucine rich repeat LRR_1 PF00560.28 ESL07738.1 - 0.0039 17.0 10.3 12 6.3 0.0 7.0 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_7 PF13504.1 ESL07738.1 - 0.0061 16.5 14.2 13 6.4 0.0 7.4 9 1 1 10 10 10 2 Leucine rich repeat G_glu_transpept PF01019.16 ESL07738.1 - 2.9 6.2 6.4 0.41 9.0 0.8 1.8 2 0 0 2 2 2 0 Gamma-glutamyltranspeptidase AhpC-TSA PF00578.16 ESL07739.1 - 1.8e-38 131.0 0.0 2.4e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESL07739.1 - 3.6e-15 55.7 0.0 5.2e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 ESL07739.1 - 1.1e-10 40.9 0.1 2.1e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DNA_pol_A PF00476.15 ESL07740.1 - 2.1e-69 234.0 0.0 1.9e-66 224.2 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase family A Glucos_trans_II PF14264.1 ESL07741.1 - 1.3 7.9 6.9 0.092 11.7 0.6 1.8 2 0 0 2 2 2 0 Glucosyl transferase GtrII HEAT_EZ PF13513.1 ESL07742.1 - 0.0022 18.4 2.2 0.2 12.2 0.0 4.3 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.17 ESL07742.1 - 0.0091 15.9 2.4 0.39 10.9 0.1 4.5 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 ESL07742.1 - 0.011 16.0 2.0 0.14 12.4 0.0 3.6 3 1 0 3 3 3 0 HEAT repeats BSP_II PF05432.6 ESL07742.1 - 0.018 14.3 13.7 0.028 13.6 9.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Vac14_Fab1_bd PF12755.2 ESL07742.1 - 0.038 14.3 0.0 0.39 11.1 0.0 2.6 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF2435 PF10363.4 ESL07742.1 - 0.078 12.8 0.1 0.38 10.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2435) Daxx PF03344.10 ESL07742.1 - 8.2 4.7 10.6 14 3.9 7.3 1.3 1 0 0 1 1 1 0 Daxx Family Kelch_3 PF13415.1 ESL07743.1 - 2.8e-49 164.2 3.6 7.7e-09 35.4 0.0 7.2 7 0 0 7 7 7 7 Galactose oxidase, central domain Kelch_4 PF13418.1 ESL07743.1 - 1.2e-44 149.8 4.7 1.2e-06 28.2 0.0 6.9 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL07743.1 - 2.5e-34 116.6 6.8 4.3e-06 26.5 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 ESL07743.1 - 3.1e-32 109.8 13.4 8.7e-07 28.3 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 ESL07743.1 - 2.2e-30 103.5 7.9 6.3e-05 22.9 0.0 6.2 4 2 2 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESL07743.1 - 9.6e-26 88.5 12.9 9.6e-06 25.1 0.1 6.9 6 2 0 6 6 6 5 Kelch motif Rax2 PF12768.2 ESL07743.1 - 0.0023 17.2 0.0 0.088 12.0 0.0 2.7 3 1 0 3 3 3 1 Cortical protein marker for cell polarity PQQ_3 PF13570.1 ESL07743.1 - 0.059 13.6 0.0 11 6.4 0.0 2.7 2 0 0 2 2 2 0 PQQ-like domain PCNA_N PF00705.13 ESL07745.1 - 6.2e-43 145.3 1.2 1.4e-42 144.2 0.9 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 ESL07745.1 - 1e-35 122.4 0.0 7.6e-17 61.4 0.0 2.3 1 1 1 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 ESL07745.1 - 5.3e-08 32.2 0.0 7.7e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.11 ESL07745.1 - 1.1e-05 24.3 0.2 0.00018 20.3 0.2 2.2 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 DS PF01916.12 ESL07747.1 - 6.6e-61 206.0 0.0 1.1e-50 172.4 0.0 3.2 3 1 0 3 3 3 3 Deoxyhypusine synthase WD40 PF00400.27 ESL07748.1 - 0.058 13.3 2.0 9.6 6.2 0.0 4.8 4 0 0 4 4 4 0 WD domain, G-beta repeat Carboxyl_trans PF01039.17 ESL07749.1 - 2.7e-148 494.3 0.0 3.5e-148 494.0 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 ESL07749.1 - 3.1e-07 29.8 0.0 0.00043 19.5 0.0 2.2 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) A_deaminase PF00962.17 ESL07750.1 - 7.5e-36 123.6 0.0 1.2e-34 119.6 0.0 2.3 2 0 0 2 2 2 2 Adenosine/AMP deaminase DUF747 PF05346.6 ESL07751.1 - 3e-74 250.0 11.7 3e-74 250.0 8.1 1.3 2 0 0 2 2 2 1 Eukaryotic membrane protein family JAB PF01398.16 ESL07752.1 - 6.7e-31 106.3 0.0 1.1e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESL07752.1 - 1.5e-09 37.3 0.0 2.4e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.1 ESL07752.1 - 6.6e-08 32.6 0.0 1.4e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.8 ESL07752.1 - 0.0024 17.4 0.0 0.0059 16.1 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) WD40 PF00400.27 ESL07753.1 - 9.2e-25 85.5 2.8 4.1e-07 29.6 0.0 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat ERM PF00769.14 ESL07754.1 - 0.0054 16.2 22.3 0.0054 16.2 15.4 4.2 2 2 2 4 4 4 1 Ezrin/radixin/moesin family DUF2968 PF11180.3 ESL07754.1 - 0.0094 15.3 16.6 0.0094 15.3 11.5 5.4 2 2 3 5 5 5 1 Protein of unknown function (DUF2968) ATG16 PF08614.6 ESL07754.1 - 1.1 9.1 63.6 0.21 11.3 6.2 5.5 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 ESL07754.1 - 1.4 7.9 13.9 9.1 5.3 0.4 3.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF812 PF05667.6 ESL07754.1 - 2.1 6.7 45.4 0.71 8.3 9.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF812) AAA_13 PF13166.1 ESL07754.1 - 5.4 5.3 38.5 0.057 11.8 8.5 3.0 2 1 1 3 3 3 0 AAA domain MBOAT PF03062.14 ESL07755.1 - 1.6e-36 126.0 25.6 1.6e-36 126.0 17.7 2.0 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family STT3 PF02516.9 ESL07756.1 - 1.4e-34 119.8 27.5 1.1e-31 110.3 17.3 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT PF02366.13 ESL07756.1 - 2.7e-05 23.6 13.1 2.7e-05 23.6 9.0 2.4 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF35_N PF12172.3 ESL07757.1 - 0.11 12.4 3.8 7.2 6.6 0.1 2.7 2 1 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) SMC_N PF02463.14 ESL07758.1 - 1.1e-62 211.1 0.0 1.7e-62 210.5 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESL07758.1 - 3.3e-26 91.6 0.1 2.3e-25 88.8 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 ESL07758.1 - 1.6e-16 61.2 4.7 1.6e-16 61.2 3.3 5.8 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.1 ESL07758.1 - 6.1e-15 55.9 13.6 4.3e-09 36.7 0.1 3.8 3 1 0 4 4 4 2 AAA domain AAA_29 PF13555.1 ESL07758.1 - 1.8e-06 27.3 0.0 4.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 ESL07758.1 - 0.12 10.7 0.0 0.12 10.7 0.0 5.3 3 2 1 5 5 5 0 AAA domain DUF4250 PF14056.1 ESL07758.1 - 0.18 11.5 2.4 1.8 8.3 0.1 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4250) ABC_tran PF00005.22 ESL07758.1 - 0.57 10.4 0.0 0.57 10.4 0.0 5.6 3 2 0 3 3 3 0 ABC transporter Transaldolase PF00923.14 ESL07759.1 - 1.6e-91 306.4 0.0 1.8e-91 306.2 0.0 1.0 1 0 0 1 1 1 1 Transaldolase Peptidase_M16_C PF05193.16 ESL07760.1 - 1e-25 90.5 0.0 1.1e-14 54.4 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain M16C_assoc PF08367.6 ESL07760.1 - 7.1e-25 87.2 0.0 1.8e-24 85.9 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16C associated Peptidase_M16 PF00675.15 ESL07760.1 - 8.4e-09 35.3 0.0 6.5e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF724 PF05266.9 ESL07760.1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DEAD PF00270.24 ESL07762.1 - 1.2e-34 119.2 0.0 2e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL07762.1 - 7.3e-20 70.6 0.0 9.7e-19 67.0 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESL07762.1 - 0.0011 19.0 0.6 0.011 15.8 0.2 2.8 3 1 0 3 3 3 1 AAA domain SecA_DEAD PF07517.9 ESL07762.1 - 0.0052 16.1 0.0 0.074 12.3 0.0 2.2 2 0 0 2 2 2 1 SecA DEAD-like domain DegV PF02645.11 ESL07762.1 - 0.078 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 HMG_box PF00505.14 ESL07763.1 - 4.2e-05 23.7 4.6 0.0055 16.9 0.9 3.6 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESL07763.1 - 0.01 16.1 0.9 0.01 16.1 0.7 2.9 2 2 0 2 2 2 0 HMG-box domain Wx5_PLAF3D7 PF09688.5 ESL07764.1 - 0.5 10.3 15.0 0.86 9.5 0.4 3.6 2 1 1 3 3 3 0 Protein of unknown function (Wx5_PLAF3D7) Med15 PF09606.5 ESL07765.1 - 0.002 16.4 17.2 0.0033 15.7 11.9 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.3 ESL07765.1 - 0.0022 17.3 1.3 0.0033 16.7 0.9 1.2 1 0 0 1 1 1 1 Spt20 family DUF4557 PF15101.1 ESL07765.1 - 0.0039 17.0 9.1 0.0091 15.8 6.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4557) Suf PF05843.9 ESL07765.1 - 0.0062 16.2 2.6 0.0092 15.7 1.8 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DNA_pol3_tau_4 PF12168.3 ESL07765.1 - 0.14 12.5 12.5 0.028 14.8 4.5 2.5 2 1 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding Activator_LAG-3 PF11498.3 ESL07765.1 - 0.36 9.5 22.3 0.55 8.9 15.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 BBS2_C PF14782.1 ESL07765.1 - 1.4 7.4 7.4 2.3 6.6 5.1 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF3154 PF11351.3 ESL07765.1 - 2.9 7.6 6.9 7 6.4 2.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3154) BAF1_ABF1 PF04684.8 ESL07765.1 - 7.2 5.3 16.2 11 4.7 11.3 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor LSM PF01423.17 ESL07767.1 - 0.00016 21.1 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 LSM domain TPR_11 PF13414.1 ESL07768.1 - 0.069 12.8 0.0 0.46 10.1 0.0 2.4 1 0 0 1 1 1 0 TPR repeat TPR_2 PF07719.12 ESL07768.1 - 0.085 12.8 0.2 1.9 8.6 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat UQ_con PF00179.21 ESL07770.1 - 1.9e-17 62.9 0.0 2.1e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESL07770.1 - 0.0045 16.8 0.0 0.0053 16.6 0.0 1.3 1 1 0 1 1 1 1 RWD domain DUF2763 PF10961.3 ESL07771.1 - 1.6e-07 31.6 0.0 1.7e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2763) Sec10 PF07393.6 ESL07772.1 - 3.7e-28 98.1 0.0 3.6e-25 88.2 0.0 2.2 1 1 0 2 2 2 2 Exocyst complex component Sec10 Fumerase PF05681.9 ESL07774.1 - 2.2e-87 292.5 0.0 2.9e-87 292.1 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.7 ESL07774.1 - 3.5e-79 264.7 0.0 6.8e-79 263.7 0.0 1.5 2 0 0 2 2 2 1 Fumarase C-terminus MMR_HSR1 PF01926.18 ESL07775.1 - 4.8e-17 61.9 0.0 9.6e-17 61.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 ESL07775.1 - 3e-16 59.0 0.0 6.8e-16 57.8 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 ESL07775.1 - 4.8e-10 38.9 0.0 2.5e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESL07775.1 - 0.0011 18.4 0.1 2.9 7.2 0.0 3.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain ArgK PF03308.11 ESL07775.1 - 0.0027 16.5 0.1 0.0096 14.7 0.1 1.8 2 0 0 2 2 2 1 ArgK protein Dynamin_N PF00350.18 ESL07775.1 - 0.0066 16.2 0.2 0.89 9.3 0.0 2.3 1 1 1 2 2 2 1 Dynamin family Miro PF08477.8 ESL07775.1 - 0.034 14.6 0.0 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein AAA_28 PF13521.1 ESL07775.1 - 0.046 13.6 0.1 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Arf PF00025.16 ESL07775.1 - 0.081 12.1 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family Trichoplein PF13868.1 ESL07776.1 - 6.3e-15 54.4 45.8 7.1e-15 54.2 31.7 1.0 1 0 0 1 1 1 1 Tumour suppressor, Mitostatin R-HINP1I PF11463.3 ESL07776.1 - 0.011 15.1 0.7 0.016 14.5 0.2 1.5 1 1 1 2 2 2 0 R.HinP1I restriction endonuclease PXA PF02194.10 ESL07776.1 - 0.9 9.0 7.9 1.2 8.7 5.4 1.2 1 0 0 1 1 1 0 PXA domain IncFII_repA PF02387.10 ESL07776.1 - 3 6.9 15.3 4 6.5 10.6 1.2 1 0 0 1 1 1 0 IncFII RepA protein family Atg14 PF10186.4 ESL07776.1 - 7.6 5.3 16.8 10 4.9 11.7 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IF4E PF01652.13 ESL07777.1 - 1.3e-55 187.3 0.3 4.1e-54 182.5 0.2 2.0 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E Serglycin PF04360.7 ESL07778.1 - 0.0042 16.8 0.6 0.0042 16.8 0.4 2.0 2 0 0 2 2 2 1 Serglycin MCRS_N PF13325.1 ESL07779.1 - 3.1e-05 23.5 0.0 5.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein Myb_DNA-bind_6 PF13921.1 ESL07779.1 - 0.0028 17.7 0.0 0.0072 16.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESL07779.1 - 0.003 17.5 0.0 0.0078 16.2 0.0 1.8 1 1 0 1 1 1 1 Myb-like DNA-binding domain CobW_C PF07683.9 ESL07779.1 - 0.13 12.0 0.1 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain ELO PF01151.13 ESL07780.1 - 4e-70 235.9 15.7 4.6e-70 235.7 10.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Bestrophin PF01062.16 ESL07780.1 - 0.25 10.2 5.9 0.47 9.3 4.1 1.4 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Ribosomal_L3 PF00297.17 ESL07782.1 - 1.8e-23 83.3 0.4 2.5e-23 82.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L3 MgtE PF01769.11 ESL07783.1 - 2.4e-14 53.7 2.7 2.4e-14 53.7 1.9 1.6 2 0 0 2 2 2 1 Divalent cation transporter Adaptin_N PF01602.15 ESL07784.1 - 2.8e-71 240.4 12.8 3.6e-71 240.0 8.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 ESL07784.1 - 2.5e-35 121.5 3.2 7e-35 120.0 2.2 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 ESL07784.1 - 0.00033 20.8 5.6 0.65 10.3 0.0 4.2 3 3 0 3 3 3 2 HEAT repeats Cnd1 PF12717.2 ESL07784.1 - 0.0038 17.1 3.4 4 7.2 2.4 3.1 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Ins_P5_2-kin PF06090.7 ESL07785.1 - 2e-16 59.9 0.0 2.5e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase CoA_trans PF01144.18 ESL07787.1 - 3.2e-32 111.4 0.2 3.6e-32 111.3 0.2 1.0 1 0 0 1 1 1 1 Coenzyme A transferase AcetylCoA_hyd_C PF13336.1 ESL07787.1 - 0.00011 21.9 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Rhabdo_glycop PF00974.13 ESL07788.1 - 0.024 12.8 0.0 0.036 12.3 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Use1 PF09753.4 ESL07788.1 - 0.05 13.0 0.1 0.63 9.4 0.0 2.2 2 0 0 2 2 2 0 Membrane fusion protein Use1 DUF4461 PF14688.1 ESL07788.1 - 0.089 12.1 0.0 0.23 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4461) DLIC PF05783.6 ESL07789.1 - 8.5e-07 27.9 0.1 1.7e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) EFG_IV PF03764.13 ESL07790.1 - 1.5e-36 124.5 0.0 3.4e-36 123.4 0.0 1.5 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 ESL07790.1 - 8.6e-22 76.8 0.0 1.5e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus MCM PF00493.18 ESL07792.1 - 5.6e-85 285.0 0.0 7.5e-85 284.6 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 ESL07792.1 - 5.3e-08 32.2 0.1 8.8e-06 25.0 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESL07792.1 - 1.9e-07 30.8 0.0 3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESL07792.1 - 0.036 13.6 0.0 0.082 12.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESL07792.1 - 0.045 13.2 0.0 0.63 9.4 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain MS_channel PF00924.13 ESL07793.1 - 4.1e-20 72.0 0.2 4.9e-20 71.7 0.2 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel Arylesterase PF01731.15 ESL07793.1 - 0.11 12.5 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Arylesterase Hrs_helical PF12210.3 ESL07794.1 - 0.082 13.1 0.6 0.12 12.6 0.1 1.6 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF179 PF02622.10 ESL07795.1 - 8.4e-27 93.7 0.0 1.4e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Clathrin PF00637.15 ESL07797.1 - 5.2e-12 45.5 24.4 0.04 13.5 0.0 10.5 4 2 6 11 11 11 3 Region in Clathrin and VPS TPR_14 PF13428.1 ESL07797.1 - 8e-05 22.9 27.0 26 5.8 0.1 14.2 12 6 5 17 17 17 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07797.1 - 0.00025 20.6 21.6 36 4.4 0.0 12.1 12 2 1 13 13 13 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.9 ESL07797.1 - 0.0034 16.2 0.2 0.0034 16.2 0.1 3.9 4 1 1 5 5 5 1 Coatomer WD associated region PPR PF01535.15 ESL07797.1 - 0.0035 17.2 8.3 22 5.2 0.1 7.7 9 0 0 9 9 9 0 PPR repeat Utp13 PF08625.6 ESL07797.1 - 0.033 13.8 0.8 1.8 8.2 0.2 3.4 3 1 0 3 3 3 0 Utp13 specific WD40 associated domain TPR_1 PF00515.23 ESL07797.1 - 0.046 13.3 34.7 11 5.8 0.0 12.1 14 1 1 15 15 15 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL07797.1 - 0.17 11.9 37.8 10 6.3 0.1 12.8 13 1 0 13 13 12 0 Tetratricopeptide repeat zf-ribbon_3 PF13248.1 ESL07797.1 - 0.2 10.9 0.6 0.39 9.9 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain TPR_11 PF13414.1 ESL07797.1 - 0.21 11.2 43.8 13 5.5 0.3 12.7 10 4 2 12 12 12 0 TPR repeat TPR_12 PF13424.1 ESL07797.1 - 0.29 11.1 36.0 0.66 9.9 0.1 10.8 9 3 1 10 10 10 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 ESL07797.1 - 1.4 8.7 13.4 1.6 8.5 1.0 4.9 6 1 0 6 6 6 0 Mad3/BUB1 homology region 1 YL1 PF05764.8 ESL07799.1 - 4.3e-11 42.8 9.6 6e-11 42.4 6.6 1.2 1 0 0 1 1 1 1 YL1 nuclear protein WD40 PF00400.27 ESL07800.1 - 0.00045 19.9 15.2 0.47 10.4 0.0 6.7 7 1 0 7 7 7 4 WD domain, G-beta repeat Pkinase PF00069.20 ESL07802.1 - 2.5e-24 85.8 0.0 7.4e-10 38.4 0.0 4.5 4 2 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07802.1 - 8.8e-13 47.9 0.0 0.0027 16.7 0.0 3.8 4 1 0 4 4 4 3 Protein tyrosine kinase Kinesin PF00225.18 ESL07803.1 - 7.8e-45 153.0 0.0 4.1e-19 68.4 0.0 3.3 3 0 0 3 3 3 3 Kinesin motor domain CBF PF03914.12 ESL07805.1 - 3e-32 111.3 1.2 3e-32 111.3 0.8 2.7 3 1 0 3 3 3 1 CBF/Mak21 family TFIIA PF03153.8 ESL07805.1 - 0.052 13.4 5.5 0.085 12.7 3.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.5 ESL07805.1 - 9.7 5.1 15.7 16 4.4 10.9 1.3 1 0 0 1 1 1 0 BUD22 ADK PF00406.17 ESL07806.1 - 1.3e-25 90.0 0.0 1.5e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 ESL07806.1 - 1.8e-13 49.8 0.0 3.8e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 ESL07806.1 - 7.3e-08 33.2 0.0 3.6e-07 31.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL07806.1 - 0.00091 19.5 0.0 0.0016 18.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL07806.1 - 0.0015 18.4 0.0 0.0049 16.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESL07806.1 - 0.0018 18.2 0.0 0.003 17.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL07806.1 - 0.0025 17.5 0.1 0.019 14.7 0.0 2.3 2 1 0 2 2 2 1 Part of AAA domain AAA_5 PF07728.9 ESL07806.1 - 0.029 14.0 0.0 0.079 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.12 ESL07806.1 - 0.036 13.4 0.0 0.51 9.6 0.0 2.5 3 0 0 3 3 3 0 Thymidylate kinase Sulfotransfer_3 PF13469.1 ESL07806.1 - 0.052 14.4 3.8 0.13 13.2 2.6 1.7 1 1 0 1 1 1 0 Sulfotransferase family RuvB_N PF05496.7 ESL07806.1 - 0.059 12.3 0.0 0.096 11.7 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus ATP-sulfurylase PF01747.12 ESL07806.1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 ATP-sulfurylase AAA PF00004.24 ESL07806.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CPSF100_C PF13299.1 ESL07807.1 - 4.1e-24 85.5 0.0 1e-23 84.2 0.0 1.6 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 ESL07807.1 - 1.2e-09 38.1 0.0 2.6e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Paf1 PF03985.8 ESL07809.1 - 0.0052 15.5 2.4 0.0072 15.1 1.7 1.1 1 0 0 1 1 1 1 Paf1 Nop14 PF04147.7 ESL07809.1 - 0.011 13.7 5.8 0.014 13.3 4.0 1.1 1 0 0 1 1 1 0 Nop14-like family Osteopontin PF00865.13 ESL07809.1 - 0.011 14.9 10.2 0.018 14.2 7.0 1.3 1 0 0 1 1 1 0 Osteopontin CDC45 PF02724.9 ESL07809.1 - 0.027 12.5 5.8 0.043 11.8 4.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Hairy_orange PF07527.8 ESL07809.1 - 0.032 13.9 1.3 0.08 12.6 0.1 2.2 2 0 0 2 2 2 0 Hairy Orange FAM176 PF14851.1 ESL07809.1 - 0.032 13.9 1.8 0.054 13.1 1.2 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.6 ESL07809.1 - 0.042 13.6 2.7 0.076 12.8 1.9 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Myc_N PF01056.13 ESL07809.1 - 0.05 12.7 2.3 0.074 12.2 1.6 1.3 1 0 0 1 1 1 0 Myc amino-terminal region TCTP PF00838.12 ESL07809.1 - 0.098 12.6 0.3 0.22 11.5 0.2 1.6 1 0 0 1 1 1 0 Translationally controlled tumour protein Pox_RNA_Pol_19 PF05320.7 ESL07809.1 - 0.12 12.1 2.9 0.18 11.5 2.0 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Nucleoplasmin PF03066.10 ESL07809.1 - 0.15 11.5 6.5 0.28 10.6 4.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin CobT PF06213.7 ESL07809.1 - 0.86 8.6 14.0 1.4 7.9 9.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.11 ESL07809.1 - 1.5 7.7 5.8 2.3 7.1 4.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cwf_Cwc_15 PF04889.7 ESL07809.1 - 2.4 7.8 11.3 20 4.7 7.8 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Daxx PF03344.10 ESL07809.1 - 3.5 5.9 11.0 5.7 5.3 7.6 1.2 1 0 0 1 1 1 0 Daxx Family PBP1_TM PF14812.1 ESL07809.1 - 5 7.4 19.5 18 5.7 13.5 2.0 2 1 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.8 ESL07809.1 - 8.3 5.9 9.7 13 5.3 6.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region NAP PF00956.13 ESL07810.1 - 0.0003 19.9 2.2 0.01 14.9 1.6 2.1 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) EF-hand_6 PF13405.1 ESL07812.1 - 2.5e-11 42.4 0.5 0.0033 17.1 0.0 4.6 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 ESL07812.1 - 1.6e-09 36.3 0.3 0.11 11.8 0.0 5.1 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.1 ESL07812.1 - 2.7e-09 37.0 1.2 0.00034 20.7 0.4 3.1 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL07812.1 - 6e-08 32.1 3.7 0.014 14.9 0.0 4.6 2 1 3 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.1 ESL07812.1 - 0.029 14.2 0.0 0.38 10.6 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain HTH_29 PF13551.1 ESL07812.1 - 0.075 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix EFhand_Ca_insen PF08726.5 ESL07812.1 - 0.087 12.8 0.0 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Ca2+ insensitive EF hand EF-hand_5 PF13202.1 ESL07812.1 - 0.13 11.6 5.5 15 5.1 0.0 4.6 5 0 0 5 5 5 0 EF hand Pox_MCEL PF03291.11 ESL07814.1 - 1.6e-40 138.9 0.0 2.1e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme mRNA_cap_C PF03919.10 ESL07814.1 - 2.4e-10 40.6 0.1 4.6e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain mRNA_cap_enzyme PF01331.14 ESL07814.1 - 8.2e-10 38.6 0.0 1.8e-05 24.5 0.0 3.0 3 1 0 3 3 3 2 mRNA capping enzyme, catalytic domain NNMT_PNMT_TEMT PF01234.12 ESL07814.1 - 0.098 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF948 PF06103.6 ESL07815.1 - 0.018 14.8 0.0 0.045 13.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FimP PF09766.4 ESL07815.1 - 0.036 13.1 0.2 0.051 12.6 0.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein DUF4145 PF13643.1 ESL07815.1 - 0.065 13.0 0.3 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) DUF4200 PF13863.1 ESL07815.1 - 0.47 10.3 5.3 2.9 7.8 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) IncA PF04156.9 ESL07815.1 - 0.51 9.9 7.7 0.44 10.1 1.0 2.2 2 0 0 2 2 2 0 IncA protein Sigma70_ner PF04546.8 ESL07815.1 - 0.52 9.8 4.9 0.93 9.0 2.7 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region APG6 PF04111.7 ESL07815.1 - 2.5 7.0 7.9 6.2 5.7 2.4 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Methyltransf_18 PF12847.2 ESL07816.1 - 0.0029 18.1 0.0 0.0049 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL07816.1 - 0.035 13.6 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RHD3 PF05879.7 ESL07817.1 - 5.3e-109 365.2 6.6 5.9e-97 325.3 0.2 3.0 3 0 0 3 3 3 3 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.18 ESL07817.1 - 0.00053 19.8 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESL07817.1 - 0.0076 16.1 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1870 PF08965.5 ESL07817.1 - 0.034 13.8 0.1 1.5 8.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1870) ABC_tran PF00005.22 ESL07817.1 - 0.053 13.8 0.1 0.3 11.3 0.0 2.2 2 1 0 2 2 2 0 ABC transporter AAA_28 PF13521.1 ESL07817.1 - 0.057 13.3 0.1 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ESL07817.1 - 0.095 13.1 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein DUF3492 PF11997.3 ESL07819.1 - 0.66 9.4 4.6 0.67 9.4 0.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF3492) WD40 PF00400.27 ESL07821.1 - 3.7e-07 29.7 12.2 0.032 14.1 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat Dynein_heavy PF03028.10 ESL07821.1 - 0.00099 17.2 0.0 0.0014 16.7 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor RNA_pol_Rpb1_5 PF04998.12 ESL07822.1 - 1.9e-25 89.6 0.0 2.5e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_7 PF04990.7 ESL07822.1 - 9.2e-05 22.1 0.2 0.00014 21.6 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 SlyX PF04102.7 ESL07823.1 - 0.039 14.3 1.9 0.083 13.2 0.2 2.1 1 1 1 2 2 2 0 SlyX DUF4094 PF13334.1 ESL07823.1 - 0.048 14.0 6.1 0.055 13.8 3.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) FliD_C PF07195.7 ESL07823.1 - 0.062 12.5 0.6 0.072 12.3 0.4 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus PRP1_N PF06424.7 ESL07823.1 - 0.09 13.0 9.1 0.11 12.8 6.3 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Seryl_tRNA_N PF02403.17 ESL07823.1 - 0.15 12.0 9.6 0.39 10.7 6.6 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.6 ESL07823.1 - 0.25 10.7 6.7 0.057 12.8 2.2 1.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 MRP-L28 PF09812.4 ESL07823.1 - 0.6 9.9 6.6 0.39 10.5 3.5 1.3 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L28 Bap31 PF05529.7 ESL07823.1 - 1.7 8.0 5.0 2.4 7.5 3.4 1.3 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF2870 PF11069.3 ESL07823.1 - 1.9 8.5 8.5 0.41 10.6 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2870) IATP PF04568.7 ESL07823.1 - 2 8.5 13.3 9.9 6.2 9.1 2.3 1 1 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP DUF4140 PF13600.1 ESL07823.1 - 4.1 7.9 5.3 17 5.9 3.7 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HSP70 PF00012.15 ESL07823.1 - 7.7 4.2 7.5 8.4 4.1 5.2 1.0 1 0 0 1 1 1 0 Hsp70 protein Atg14 PF10186.4 ESL07823.1 - 8.1 5.2 10.4 23 3.7 7.4 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_2 PF07724.9 ESL07824.1 - 2.8e-41 141.2 1.6 6.3e-33 114.0 0.1 2.7 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESL07824.1 - 1.4e-13 51.1 0.2 3.9e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL07824.1 - 2e-08 34.0 0.5 2.3e-05 24.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESL07824.1 - 1.4e-06 28.4 0.1 0.00021 21.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESL07824.1 - 9.5e-06 25.7 0.4 2.6e-05 24.2 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESL07824.1 - 1e-05 26.3 0.1 3.8e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain MCM PF00493.18 ESL07824.1 - 3.8e-05 22.6 0.1 0.0016 17.3 0.0 2.5 2 0 0 2 2 2 1 MCM2/3/5 family AAA_18 PF13238.1 ESL07824.1 - 7e-05 23.1 0.2 0.00022 21.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain ClpB_D2-small PF10431.4 ESL07824.1 - 9.5e-05 22.2 0.6 0.00035 20.4 0.0 2.3 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein Mg_chelatase PF01078.16 ESL07824.1 - 0.00039 19.6 0.0 0.0025 16.9 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 ESL07824.1 - 0.00044 20.1 0.0 0.85 9.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 ESL07824.1 - 0.00053 18.8 0.2 0.0011 17.7 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus T2SE PF00437.15 ESL07824.1 - 0.00057 18.8 0.0 0.0013 17.6 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.1 ESL07824.1 - 0.00098 19.0 0.1 0.0087 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESL07824.1 - 0.0011 18.0 0.1 0.0051 15.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 ESL07824.1 - 0.0021 17.1 0.1 0.0073 15.4 0.1 1.8 1 1 1 2 2 2 1 Zeta toxin NTPase_1 PF03266.10 ESL07824.1 - 0.0028 17.3 1.3 0.45 10.2 0.0 2.5 2 0 0 2 2 2 1 NTPase DEAD PF00270.24 ESL07824.1 - 0.0047 16.4 0.2 0.24 10.8 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase ATP-synt_ab PF00006.20 ESL07824.1 - 0.0089 15.5 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain IstB_IS21 PF01695.12 ESL07824.1 - 0.015 14.7 0.0 0.038 13.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein UPF0079 PF02367.12 ESL07824.1 - 0.016 14.8 0.0 0.4 10.3 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 ABC_tran PF00005.22 ESL07824.1 - 0.017 15.3 0.0 0.049 13.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.21 ESL07824.1 - 0.02 14.3 0.1 0.057 12.8 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain CPT PF07931.7 ESL07824.1 - 0.035 13.7 0.2 0.23 11.0 0.0 2.4 3 0 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.1 ESL07824.1 - 0.042 13.8 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 ESL07824.1 - 0.044 13.7 0.0 0.35 10.8 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF258 PF03193.11 ESL07824.1 - 0.048 12.8 0.0 0.086 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RNA_helicase PF00910.17 ESL07824.1 - 0.056 13.6 0.0 0.77 9.9 0.0 2.7 3 0 0 3 3 3 0 RNA helicase RNase_Zc3h12a PF11977.3 ESL07825.1 - 0.084 12.6 0.0 0.74 9.6 0.0 2.4 2 1 0 2 2 2 0 Zc3h12a-like Ribonuclease NYN domain Nup35_RRM_2 PF14605.1 ESL07826.1 - 5.1e-18 64.5 0.1 7.9e-18 63.9 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 ESL07826.1 - 0.085 12.6 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif NdhL PF10716.4 ESL07826.1 - 0.35 10.6 1.9 0.64 9.8 1.3 1.3 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit Elf1 PF05129.8 ESL07827.1 - 0.073 12.7 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like WD40 PF00400.27 ESL07828.1 - 9.5e-10 37.9 1.7 0.00059 19.6 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat MFS_1 PF07690.11 ESL07829.1 - 2.1e-16 59.6 43.9 5.4e-08 31.9 13.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESL07829.1 - 7.3e-05 21.5 31.4 7.6e-05 21.4 3.9 3.4 3 1 0 3 3 3 2 Sugar (and other) transporter DnaJ PF00226.26 ESL07830.1 - 9.2e-15 54.1 0.0 2.1e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Mito_carr PF00153.22 ESL07831.1 - 2.7e-54 180.8 2.4 5.8e-21 74.0 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 ESL07831.1 - 0.0009 19.2 0.2 2.7 8.0 0.1 3.6 2 1 2 4 4 4 4 Tim17/Tim22/Tim23/Pmp24 family Pkinase PF00069.20 ESL07832.1 - 2.7e-63 213.5 0.0 3.9e-63 213.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07832.1 - 4.2e-31 107.9 0.1 1e-30 106.7 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESL07832.1 - 6.6e-07 28.6 0.3 1.1e-06 27.9 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL07832.1 - 1.1e-05 24.6 0.0 2.4e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESL07832.1 - 0.016 14.5 0.5 0.032 13.5 0.3 1.6 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.6 ESL07832.1 - 0.027 13.3 0.1 0.046 12.5 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 ESL07832.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_19 PF14559.1 ESL07833.1 - 1e-14 54.5 0.0 0.00075 19.7 0.0 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESL07833.1 - 3.1e-12 46.8 0.0 0.00011 22.7 0.0 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL07833.1 - 4.3e-10 39.3 0.9 0.14 12.8 0.0 5.7 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESL07833.1 - 4.6e-10 38.6 18.2 0.021 14.6 0.1 6.9 7 0 0 7 7 6 4 Tetratricopeptide repeat Apc3 PF12895.2 ESL07833.1 - 1.9e-09 37.5 15.7 0.0012 18.9 2.1 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 ESL07833.1 - 4.5e-09 35.8 9.6 0.00017 21.1 0.0 4.5 4 1 0 4 4 4 2 TPR repeat Coatomer_E PF04733.9 ESL07833.1 - 0.00048 19.3 1.4 0.53 9.4 0.2 3.2 3 0 0 3 3 3 2 Coatomer epsilon subunit TPR_6 PF13174.1 ESL07833.1 - 0.00051 20.3 4.9 19 6.0 0.0 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07833.1 - 0.0008 18.9 14.0 0.31 10.7 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL07833.1 - 0.0023 17.8 10.5 0.64 9.9 0.1 6.1 4 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL07833.1 - 0.0034 17.0 2.0 0.36 10.7 0.1 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL07833.1 - 0.0049 16.6 0.2 0.3 10.9 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.9 ESL07833.1 - 0.0052 17.0 0.0 1.8 9.2 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL07833.1 - 0.017 14.9 3.0 1.2 9.0 0.2 3.7 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 ESL07833.1 - 0.36 10.8 5.1 5.4 7.1 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat DGF-1_C PF11040.3 ESL07834.1 - 1.1e-22 79.7 0.3 2.2e-22 78.7 0.2 1.5 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4227 PF14004.1 ESL07834.1 - 0.0014 18.4 0.2 0.0038 17.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4227) DUF1183 PF06682.7 ESL07834.1 - 0.063 12.8 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Tweety PF04906.8 ESL07834.1 - 0.07 11.5 0.1 0.12 10.7 0.0 1.3 1 0 0 1 1 1 0 Tweety NfeD PF01957.13 ESL07834.1 - 0.13 12.3 1.0 0.18 11.9 0.7 1.1 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding Glycos_transf_4 PF00953.16 ESL07834.1 - 0.14 11.9 5.9 0.19 11.4 4.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 4 ArfGap PF01412.13 ESL07835.1 - 9.8e-31 105.9 0.1 1.7e-30 105.2 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf 60KD_IMP PF02096.15 ESL07836.1 - 2.4e-29 102.4 0.3 3.6e-29 101.8 0.2 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein TetR_C_7 PF14246.1 ESL07836.1 - 0.052 13.7 0.1 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal region FAM178 PF14816.1 ESL07836.1 - 0.3 9.7 1.0 0.48 9.0 0.7 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 HTH_Tnp_Tc3_2 PF01498.13 ESL07839.1 - 0.12 12.3 0.1 0.39 10.7 0.1 1.8 1 0 0 1 1 1 0 Transposase DUF3669 PF12417.3 ESL07841.1 - 0.052 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Zinc finger protein NAD_binding_4 PF07993.7 ESL07842.1 - 1.8e-62 210.5 0.0 2.6e-62 209.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.14 ESL07842.1 - 2.2e-10 40.6 0.2 4.2e-10 39.7 0.2 1.5 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 ESL07842.1 - 6e-07 29.1 0.0 6.8e-06 25.6 0.0 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL07842.1 - 3.6e-05 22.7 0.0 0.044 12.6 0.0 2.4 2 0 0 2 2 2 2 RmlD substrate binding domain 3Beta_HSD PF01073.14 ESL07842.1 - 0.0099 14.6 2.5 0.94 8.1 0.0 3.7 5 0 0 5 5 5 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF533 PF04391.7 ESL07842.1 - 0.049 13.0 2.1 0.084 12.2 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Metallophos PF00149.23 ESL07843.1 - 4.4e-22 78.4 0.0 1.1e-21 77.2 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1691 PF07950.6 ESL07844.1 - 0.025 14.5 0.6 0.025 14.5 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1691) DcuC PF03606.10 ESL07844.1 - 0.17 10.1 0.1 0.23 9.6 0.0 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier F-actin_cap_A PF01267.12 ESL07846.1 - 8.4e-26 90.6 0.0 1.8e-24 86.2 0.0 2.5 1 1 0 1 1 1 1 F-actin capping protein alpha subunit DUF1279 PF06916.8 ESL07848.1 - 0.00012 22.3 0.0 0.00019 21.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) WW PF00397.21 ESL07848.1 - 0.00018 21.3 1.0 0.00036 20.3 0.7 1.5 1 0 0 1 1 1 1 WW domain Clat_adaptor_s PF01217.15 ESL07849.1 - 6.2e-49 165.3 3.9 6.9e-49 165.2 2.7 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain LRR_6 PF13516.1 ESL07850.1 - 2.9e-07 29.8 3.0 0.16 12.1 0.0 3.8 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.28 ESL07850.1 - 0.001 18.7 3.4 2.6 8.4 0.3 3.7 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_4 PF12799.2 ESL07850.1 - 0.043 13.4 4.8 2.6 7.7 0.7 3.2 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESL07850.1 - 3 8.4 9.7 20 5.9 0.5 4.3 4 0 0 4 4 4 0 Leucine rich repeat PGK PF00162.14 ESL07851.1 - 6.7e-131 436.3 0.0 8.3e-131 436.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase PAS PF00989.19 ESL07851.1 - 9.1e-06 25.4 0.0 2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 ESL07851.1 - 6.5e-05 23.2 0.0 0.00028 21.2 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.1 ESL07851.1 - 0.00035 20.3 0.0 0.0014 18.4 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.5 ESL07851.1 - 0.021 14.8 0.0 0.061 13.3 0.0 1.8 1 0 0 1 1 1 0 PAS fold Flavokinase PF01687.12 ESL07852.1 - 8.7e-31 106.3 0.0 1.1e-30 106.1 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase tRNA-synt_1 PF00133.17 ESL07853.1 - 2e-20 72.3 0.0 1.4e-09 36.5 0.0 2.0 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESL07853.1 - 3.7e-08 32.4 0.0 7.2e-08 31.4 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (M) PRKCSH_1 PF13015.1 ESL07854.1 - 1.8e-22 79.4 0.1 1.8e-22 79.4 0.1 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 ESL07854.1 - 1e-09 39.0 2.8 2.6e-09 37.7 1.9 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein MAP65_ASE1 PF03999.7 ESL07854.1 - 0.011 14.4 1.1 0.013 14.1 0.7 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TBPIP PF07106.8 ESL07854.1 - 0.096 12.2 0.8 0.13 11.8 0.6 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) RmuC PF02646.11 ESL07854.1 - 0.16 10.7 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 RmuC family Ribosomal_L38e PF01781.13 ESL07855.1 - 4.1e-30 103.3 4.3 4.9e-30 103.0 3.0 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family DUF2359 PF10151.4 ESL07855.1 - 0.023 13.2 0.1 0.023 13.2 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2359) US22 PF02393.11 ESL07856.1 - 0.084 12.9 0.5 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 US22 like HSP90 PF00183.13 ESL07857.1 - 2.5e-262 871.0 32.5 2.9e-262 870.8 22.5 1.0 1 0 0 1 1 1 1 Hsp90 protein DUF1510 PF07423.6 ESL07857.1 - 0.0078 15.5 12.6 0.0078 15.5 8.8 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) LOH1CR12 PF10158.4 ESL07857.1 - 0.023 14.4 0.4 0.071 12.9 0.3 1.8 1 0 0 1 1 1 0 Tumour suppressor protein Acyltransferase PF01553.16 ESL07858.1 - 5.5e-09 35.5 0.0 1.1e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase GDPD PF03009.12 ESL07860.1 - 1.7e-18 67.0 0.0 1.1e-17 64.4 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Peptidase_M16_C PF05193.16 ESL07861.1 - 3.8e-16 59.3 0.0 7.4e-16 58.3 0.0 1.5 1 1 0 1 1 1 1 Peptidase M16 inactive domain Pyr_redox_2 PF07992.9 ESL07862.1 - 4.2e-42 144.3 1.5 7.8e-42 143.4 1.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESL07862.1 - 2.3e-40 137.0 0.3 6.9e-40 135.4 0.2 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ESL07862.1 - 7.1e-21 74.4 7.0 4.7e-18 65.3 0.3 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESL07862.1 - 8.9e-11 41.5 0.5 8.9e-11 41.5 0.4 3.3 3 1 1 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESL07862.1 - 2.7e-10 40.6 1.0 1e-05 25.7 0.2 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESL07862.1 - 3.1e-09 36.2 9.4 2.6e-06 26.5 4.6 3.1 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.19 ESL07862.1 - 1.3e-07 30.8 14.8 4.7e-07 28.9 2.1 3.5 3 1 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.1 ESL07862.1 - 1.6e-06 28.0 4.2 0.00048 20.1 0.4 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESL07862.1 - 5.2e-06 25.7 0.5 0.00025 20.2 0.0 2.7 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 ESL07862.1 - 1.6e-05 24.1 11.4 0.2 10.6 0.0 3.2 2 1 1 3 3 3 3 FAD binding domain K_oxygenase PF13434.1 ESL07862.1 - 7.7e-05 21.7 0.2 0.046 12.6 0.0 2.6 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 ESL07862.1 - 0.00025 19.6 13.7 0.00074 18.0 0.9 3.8 3 1 1 4 4 4 1 HI0933-like protein AlaDh_PNT_C PF01262.16 ESL07862.1 - 0.0021 17.6 2.0 0.25 10.9 0.0 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 ESL07862.1 - 0.0035 17.0 0.2 0.0035 17.0 0.1 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 ESL07862.1 - 0.0041 16.0 19.9 0.046 12.6 1.9 4.0 2 2 1 4 4 4 2 FAD dependent oxidoreductase XdhC_C PF13478.1 ESL07862.1 - 0.0064 16.7 0.0 0.4 10.9 0.0 2.3 2 0 0 2 2 2 1 XdhC Rossmann domain NAD_binding_7 PF13241.1 ESL07862.1 - 0.084 13.1 1.2 1.6 9.0 0.1 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.7 ESL07862.1 - 4.2 6.1 8.9 0.88 8.4 0.5 2.8 2 1 1 3 3 3 0 Lycopene cyclase protein WD40 PF00400.27 ESL07863.1 - 2.2e-38 128.7 5.2 3.2e-06 26.8 0.2 10.3 11 0 0 11 11 11 7 WD domain, G-beta repeat Utp12 PF04003.7 ESL07863.1 - 0.00013 21.8 0.2 0.00048 20.0 0.1 1.9 1 1 0 1 1 1 1 Dip2/Utp12 Family RAB3GAP2_N PF14655.1 ESL07863.1 - 0.0035 16.4 0.0 0.025 13.5 0.0 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus YscO PF07321.7 ESL07864.1 - 6.3e-15 55.3 11.1 6.3e-15 55.3 7.7 13.9 12 5 3 15 15 15 3 Type III secretion protein YscO Cullin PF00888.17 ESL07865.1 - 4.1e-80 269.9 0.0 5.7e-80 269.5 0.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESL07865.1 - 4.8e-26 90.3 1.0 2.3e-25 88.1 0.1 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain DUF2012 PF09430.5 ESL07866.1 - 2.8e-31 107.9 0.0 3.8e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.1 ESL07866.1 - 4.8e-05 23.3 0.1 9.6e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Pcc1 PF09341.5 ESL07867.1 - 3e-17 62.4 0.2 4.1e-17 61.9 0.2 1.2 1 0 0 1 1 1 1 Transcription factor Pcc1 HA2 PF04408.18 ESL07868.1 - 1.2e-18 67.0 0.0 3.2e-18 65.6 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESL07868.1 - 3.9e-14 52.4 0.0 1.2e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESL07868.1 - 1.1e-11 44.3 0.2 2.5e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL07868.1 - 0.0099 15.3 0.0 0.039 13.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Ras PF00071.17 ESL07869.1 - 7.1e-19 67.7 0.0 1.1e-09 37.8 0.0 2.2 2 0 0 2 2 2 2 Ras family Miro PF08477.8 ESL07869.1 - 2.9e-05 24.5 0.0 0.23 11.9 0.0 2.9 2 1 0 2 2 2 2 Miro-like protein Aminotran_5 PF00266.14 ESL07870.1 - 2.3e-11 43.0 0.0 3.3e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.20 ESL07871.1 - 2e-46 158.2 0.0 2e-41 141.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07871.1 - 3.1e-15 55.9 0.0 5.3e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL07871.1 - 0.0017 18.1 0.0 0.0039 16.9 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESL07871.1 - 0.17 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Glutaredoxin PF00462.19 ESL07872.1 - 2.1e-12 46.8 0.1 2.8e-12 46.4 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 ESL07872.1 - 9.3e-05 22.1 0.1 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin PF00085.15 ESL07872.1 - 0.066 12.9 0.0 0.073 12.7 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin EF-hand_7 PF13499.1 ESL07873.1 - 1.1e-08 35.0 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL07873.1 - 9.1e-06 25.1 0.0 0.00017 21.1 0.0 2.8 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESL07873.1 - 4.1e-05 23.1 0.0 0.002 17.8 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_9 PF14658.1 ESL07873.1 - 0.018 14.9 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.27 ESL07873.1 - 0.021 14.0 0.0 0.35 10.2 0.0 2.6 2 0 0 2 2 2 0 EF hand TPR_8 PF13181.1 ESL07874.1 - 0.0013 18.3 0.0 0.17 11.7 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL07874.1 - 0.0067 16.2 0.0 0.047 13.6 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL07874.1 - 0.0072 15.9 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.1 ESL07874.1 - 0.012 15.5 0.0 0.12 12.3 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL07874.1 - 0.09 12.4 0.0 0.56 9.9 0.0 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Ras PF00071.17 ESL07875.1 - 7.4e-51 171.7 0.0 9.1e-51 171.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL07875.1 - 1.2e-19 70.9 0.0 1.7e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL07875.1 - 2.7e-11 43.0 0.0 3.8e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL07875.1 - 7.4e-05 22.2 0.0 0.00017 21.0 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL07875.1 - 9.9e-05 21.5 0.0 0.00011 21.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL07875.1 - 0.00056 19.8 0.0 0.00092 19.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESL07875.1 - 0.043 13.0 0.0 0.11 11.7 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.13 ESL07875.1 - 0.19 10.7 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Septin Aminotran_5 PF00266.14 ESL07878.1 - 1.5e-23 83.1 0.0 2.1e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 ESL07878.1 - 0.11 10.7 0.1 0.17 10.1 0.1 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pet191_N PF10203.4 ESL07879.1 - 1e-15 57.5 2.5 1.3e-15 57.1 1.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Gemin6 PF06372.7 ESL07879.1 - 0.042 13.1 0.1 0.053 12.8 0.1 1.2 1 0 0 1 1 1 0 Gemin6 protein TBPIP_N PF15517.1 ESL07880.1 - 0.19 11.3 0.7 1.8 8.2 0.2 2.4 2 0 0 2 2 2 0 TBP-interacting protein N-terminus NDUFA12 PF05071.11 ESL07880.1 - 0.58 10.6 7.8 0.044 14.2 1.3 2.3 2 1 1 3 3 3 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Ribosomal_L14 PF00238.14 ESL07881.1 - 5.2e-13 48.8 0.0 1.6e-12 47.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L14p/L23e DAP10 PF07213.6 ESL07882.1 - 0.65 9.7 4.2 1.7 8.4 2.9 1.7 1 0 0 1 1 1 0 DAP10 membrane protein Methyltransf_31 PF13847.1 ESL07883.1 - 1.5e-06 27.8 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 ESL07883.1 - 0.0035 16.3 0.0 0.0037 16.2 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Response_reg PF00072.19 ESL07883.1 - 0.014 15.4 0.1 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Response regulator receiver domain Methyltransf_26 PF13659.1 ESL07883.1 - 0.029 14.3 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 ESL07883.1 - 0.034 14.9 0.0 0.068 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF2838 PF10998.3 ESL07884.1 - 5.2e-23 81.0 15.6 1.9e-21 76.0 1.4 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF2838) DUF788 PF05620.6 ESL07884.1 - 0.0075 16.1 0.1 0.0075 16.1 0.1 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF788) SseB PF07179.7 ESL07885.1 - 0.04 13.7 0.0 12 5.7 0.0 2.6 3 0 0 3 3 3 0 SseB protein N-terminal domain Pkinase PF00069.20 ESL07887.1 - 8.5e-54 182.4 0.0 1.2e-53 181.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07887.1 - 6.6e-35 120.4 0.0 1.1e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 ESL07887.1 - 1.4e-09 38.0 0.0 2.9e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 ESL07887.1 - 4.4e-08 32.4 0.0 8.4e-08 31.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Mcp5_PH PF12814.2 ESL07887.1 - 0.01 15.7 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Sybindin PF04099.7 ESL07888.1 - 7.6e-15 54.8 0.0 8.7e-15 54.6 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family DUF819 PF05684.7 ESL07889.1 - 0.0051 15.6 1.0 0.0063 15.3 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF819) Pterin_4a PF01329.14 ESL07889.1 - 0.11 12.3 1.6 0.24 11.1 0.0 2.2 3 0 0 3 3 3 0 Pterin 4 alpha carbinolamine dehydratase Arf PF00025.16 ESL07890.1 - 9.9e-50 168.1 0.0 1.3e-49 167.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESL07890.1 - 4.9e-16 58.4 0.0 6.5e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 ESL07890.1 - 3.6e-12 46.8 0.0 5.1e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESL07890.1 - 1.3e-11 44.4 0.0 1.9e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 ESL07890.1 - 5.2e-10 38.9 0.0 6.7e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 ESL07890.1 - 7.3e-09 34.7 0.0 1.3e-06 27.4 0.0 2.2 2 1 0 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.22 ESL07890.1 - 1.9e-06 27.4 0.0 3.6e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL07890.1 - 5.9e-05 22.3 0.0 9.7e-05 21.6 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.13 ESL07890.1 - 6.1e-05 22.3 0.0 0.00019 20.7 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.13 ESL07890.1 - 0.00073 18.6 0.0 0.001 18.1 0.0 1.3 1 1 0 1 1 1 1 Septin Arch_ATPase PF01637.13 ESL07890.1 - 0.0031 17.2 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase cobW PF02492.14 ESL07890.1 - 0.0048 16.3 0.0 0.3 10.4 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 ESL07890.1 - 0.011 15.9 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESL07890.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 ESL07890.1 - 0.018 14.9 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 ESL07890.1 - 0.02 14.7 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Dynamin family ABC_tran PF00005.22 ESL07890.1 - 0.021 15.1 0.0 0.029 14.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 ESL07890.1 - 0.055 13.4 0.0 0.08 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 ESL07890.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family CdhD PF03599.11 ESL07890.1 - 0.075 11.5 0.0 0.099 11.1 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit ATP_bind_1 PF03029.12 ESL07890.1 - 0.13 11.7 0.0 1.6 8.1 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein APH PF01636.18 ESL07891.1 - 4.8e-16 59.2 0.0 1.4e-15 57.7 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family HAD_2 PF13419.1 ESL07891.1 - 6.1e-05 23.3 0.1 0.0056 16.9 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase WD40 PF00400.27 ESL07893.1 - 2.7e-25 87.2 19.4 6.1e-05 22.7 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat B_lectin PF01453.19 ESL07893.1 - 0.0091 15.8 0.0 0.041 13.7 0.0 2.1 2 0 0 2 2 2 1 D-mannose binding lectin HpaB PF03241.8 ESL07893.1 - 0.055 12.3 0.1 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal 2-Hacid_dh_C PF02826.14 ESL07894.1 - 2.3e-42 144.1 0.0 2.6e-42 143.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESL07894.1 - 1.2e-06 27.9 0.0 1.5e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_10 PF13460.1 ESL07894.1 - 4.3e-06 26.8 0.0 5.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 ESL07894.1 - 6.5e-05 22.9 0.1 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESL07894.1 - 8.1e-05 22.5 0.1 9.7e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESL07894.1 - 0.0001 22.6 0.0 0.00018 21.8 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 ESL07894.1 - 0.00057 19.7 0.2 0.0018 18.1 0.1 1.8 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.14 ESL07894.1 - 0.0032 16.1 0.0 0.0032 16.1 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase NAD_binding_7 PF13241.1 ESL07894.1 - 0.0059 16.8 0.0 0.0083 16.3 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding ELFV_dehydrog PF00208.16 ESL07894.1 - 0.015 14.8 0.3 0.035 13.6 0.1 1.5 1 1 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Saccharop_dh PF03435.13 ESL07894.1 - 0.016 14.2 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Gp_dh_N PF00044.19 ESL07894.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESL07894.1 - 0.016 14.8 0.4 0.027 14.1 0.3 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 ESL07894.1 - 0.032 14.5 0.0 0.039 14.2 0.0 1.2 1 0 0 1 1 1 0 XdhC Rossmann domain Ribosomal_S24e PF01282.14 ESL07896.1 - 1.6e-28 98.3 0.0 2.9e-28 97.4 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e BPL_LplA_LipB PF03099.14 ESL07897.1 - 1.1e-17 64.1 0.0 2e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Proteasome PF00227.21 ESL07899.1 - 1e-41 142.2 0.3 1.3e-41 141.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit zf-RanBP PF00641.13 ESL07900.1 - 0.0041 16.1 2.7 0.0041 16.1 1.9 7.4 7 0 0 7 7 7 2 Zn-finger in Ran binding protein and others RNA_ligase PF09414.5 ESL07901.1 - 4.8e-50 169.9 0.0 7.2e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 RNA ligase DUF1886 PF09171.5 ESL07901.1 - 0.0065 15.5 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1886) tRNA-synt_1c PF00749.16 ESL07903.1 - 4.2e-98 327.8 0.0 6.7e-98 327.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 ESL07903.1 - 1.9e-37 128.5 0.2 3.3e-37 127.8 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.14 ESL07903.1 - 0.038 13.0 0.1 0.24 10.4 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain E1-E2_ATPase PF00122.15 ESL07904.1 - 1.9e-47 161.2 1.2 1.9e-47 161.2 0.8 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESL07904.1 - 3e-39 135.6 0.7 6.2e-39 134.6 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL07904.1 - 4.1e-18 66.2 0.0 7e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 ESL07904.1 - 2.1e-16 59.8 1.6 2.2e-07 30.9 0.1 2.9 3 0 0 3 3 3 2 Heavy-metal-associated domain Hydrolase_3 PF08282.7 ESL07904.1 - 2.1e-06 27.5 0.0 9.4e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Nicastrin PF05450.10 ESL07905.1 - 8.9e-08 31.6 0.0 1.5e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.12 ESL07905.1 - 0.00019 21.2 0.0 0.00036 20.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 ESL07905.1 - 0.03 13.8 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Adap_comp_sub PF00928.16 ESL07907.1 - 7.6e-52 175.9 0.0 1e-51 175.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESL07907.1 - 1.5e-05 24.7 0.3 2.8e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Clathrin adaptor complex small chain TruD PF01142.13 ESL07908.1 - 3e-08 32.7 0.0 4.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) DNA_pol_delta_4 PF04081.8 ESL07908.1 - 0.1 12.8 0.0 16 5.8 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase delta, subunit 4 Peptidase_M16_C PF05193.16 ESL07910.1 - 2e-22 79.7 0.1 3.9e-22 78.8 0.0 1.5 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ESL07910.1 - 0.00015 21.5 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Ribosomal_L29 PF00831.18 ESL07911.1 - 1.5e-17 62.9 5.4 1.5e-17 62.9 3.7 2.1 2 1 0 2 2 2 1 Ribosomal L29 protein MRP-L47 PF06984.8 ESL07911.1 - 0.023 14.5 1.3 0.023 14.5 0.9 1.7 2 0 0 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF2935 PF11155.3 ESL07911.1 - 0.13 12.3 1.0 0.14 12.2 0.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) Ribosomal_S9 PF00380.14 ESL07911.1 - 0.29 11.3 8.2 0.52 10.5 5.6 1.5 1 1 0 1 1 1 0 Ribosomal protein S9/S16 DUF2448 PF10476.4 ESL07912.1 - 0.043 13.3 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Pribosyl_synth PF14572.1 ESL07914.1 - 7.4e-23 81.2 0.3 3.6e-22 79.0 0.1 1.8 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ESL07914.1 - 7.5e-12 45.0 0.3 1.4e-11 44.1 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESL07914.1 - 0.034 13.3 0.1 0.044 12.9 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Clathrin PF00637.15 ESL07915.1 - 3.5e-48 162.8 7.5 8.3e-23 80.5 0.0 3.2 3 0 0 3 3 3 3 Region in Clathrin and VPS NDUF_B7 PF05676.8 ESL07917.1 - 1.5e-05 24.3 0.2 2.3e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Rhomboid PF01694.17 ESL07919.1 - 0.00021 21.3 5.1 0.00021 21.3 3.5 2.1 2 1 0 2 2 2 1 Rhomboid family RtcB PF01139.12 ESL07920.1 - 4.7e-122 408.0 0.1 5.3e-122 407.8 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DUF4460 PF14687.1 ESL07921.1 - 2.7e-09 36.7 0.2 6.1e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF4461 PF14688.1 ESL07921.1 - 5.7e-05 22.6 1.0 0.04 13.2 0.0 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF4461) vATP-synt_E PF01991.13 ESL07921.1 - 0.11 11.7 0.0 0.11 11.7 0.0 2.2 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit RNA_pol_Rpb2_6 PF00562.23 ESL07922.1 - 3.2e-106 355.3 0.0 3.8e-106 355.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.15 ESL07922.1 - 2.3e-28 98.2 0.0 4.4e-28 97.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Pkinase PF00069.20 ESL07923.1 - 1.9e-55 187.8 0.0 3.7e-54 183.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07923.1 - 1.8e-39 135.3 0.0 5.3e-24 84.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESL07923.1 - 9.6e-05 21.4 0.1 0.052 12.5 0.0 2.8 3 0 0 3 3 3 2 Kinase-like APH PF01636.18 ESL07923.1 - 0.00025 20.8 2.2 0.00041 20.1 0.2 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL07923.1 - 0.076 12.0 0.2 0.22 10.5 0.1 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PNK3P PF08645.6 ESL07925.1 - 1e-46 158.3 0.0 2.1e-46 157.2 0.0 1.5 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 ESL07925.1 - 3.2e-14 53.0 0.0 1.7e-13 50.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL07925.1 - 0.00024 20.2 0.0 0.00051 19.1 0.0 1.5 1 1 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 ESL07925.1 - 0.064 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESL07925.1 - 0.069 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.1 ESL07925.1 - 0.08 13.7 0.0 0.22 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESL07925.1 - 0.086 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 ESL07925.1 - 0.091 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.5 ESL07925.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL07925.1 - 0.17 11.8 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF498 PF04430.9 ESL07926.1 - 1e-22 79.7 0.0 1.9e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) zf-Sec23_Sec24 PF04810.10 ESL07928.1 - 4.2e-14 51.8 5.3 4.2e-14 51.8 3.7 2.4 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_trunk PF04811.10 ESL07928.1 - 8.8e-13 48.1 0.3 1.4e-12 47.5 0.1 1.4 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Robl_LC7 PF03259.12 ESL07929.1 - 0.0011 18.4 0.4 0.092 12.3 0.3 2.5 1 1 0 1 1 1 1 Roadblock/LC7 domain PMP22_Claudin PF00822.15 ESL07929.1 - 0.051 13.2 0.1 0.059 13.0 0.1 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family LT-IIB PF06453.6 ESL07929.1 - 0.078 12.6 0.1 0.31 10.7 0.0 1.7 1 1 1 2 2 2 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) Dynein_heavy PF03028.10 ESL07930.1 - 0.17 9.9 0.0 0.17 9.9 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor ATP_synt_H PF05493.8 ESL07931.1 - 0.0085 16.1 2.2 0.0085 16.1 1.5 2.1 2 0 0 2 2 2 1 ATP synthase subunit H 5TM-5TMR_LYT PF07694.7 ESL07931.1 - 0.047 13.0 0.7 0.081 12.2 0.5 1.5 1 1 0 1 1 1 0 5TMR of 5TMR-LYT DUF1751 PF08551.5 ESL07931.1 - 0.14 12.5 1.6 0.42 10.9 0.3 2.2 2 1 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) RNase_PH PF01138.16 ESL07932.1 - 3.2e-15 56.5 0.1 4.8e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESL07932.1 - 0.065 13.1 0.5 0.16 11.8 0.1 1.8 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 Lipase_GDSL_2 PF13472.1 ESL07933.1 - 2.1e-11 44.2 0.0 6e-11 42.7 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ESL07933.1 - 1e-07 32.0 0.0 6.6e-07 29.3 0.0 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Cu-binding_MopE PF11617.3 ESL07933.1 - 0.002 17.8 7.7 0.0045 16.7 5.3 1.6 1 0 0 1 1 1 1 Protein metal binding site Acyl-CoA_dh_1 PF00441.19 ESL07937.1 - 2.4e-40 138.0 2.9 2.4e-40 138.0 2.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESL07937.1 - 2.9e-29 101.9 0.0 9.1e-29 100.3 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESL07937.1 - 6.3e-19 67.2 0.3 1.2e-18 66.3 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESL07937.1 - 4.7e-18 65.7 1.3 1e-17 64.6 0.9 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.1 ESL07937.1 - 0.002 18.4 0.0 0.0034 17.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal SlyX PF04102.7 ESL07938.1 - 0.031 14.6 5.3 0.2 12.0 0.3 3.0 3 0 0 3 3 3 0 SlyX BMFP PF04380.8 ESL07938.1 - 0.055 13.5 4.1 3.2 7.9 0.2 2.9 2 1 0 2 2 2 0 Membrane fusogenic activity DUF4482 PF14818.1 ESL07938.1 - 0.059 14.0 0.9 0.059 14.0 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Paramyx_P_V_C PF03210.8 ESL07938.1 - 0.097 12.5 0.4 0.22 11.3 0.1 1.7 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal Tropomyosin_1 PF12718.2 ESL07938.1 - 0.4 10.5 3.7 0.81 9.5 2.0 1.8 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.3 ESL07938.1 - 2.2 8.1 6.3 12 5.7 3.7 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Mnd1 PF03962.10 ESL07938.1 - 2.5 7.7 7.4 6.8 6.3 1.8 2.3 1 1 2 3 3 3 0 Mnd1 family GDI PF00996.13 ESL07940.1 - 7.9e-32 110.1 0.0 6.5e-23 80.7 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor Methyltransf_16 PF10294.4 ESL07940.1 - 4e-14 52.4 0.0 1.7e-07 30.8 0.0 2.4 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_18 PF12847.2 ESL07940.1 - 0.0031 18.0 0.0 0.018 15.6 0.0 2.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESL07940.1 - 0.016 14.3 0.0 0.031 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NNMT_PNMT_TEMT PF01234.12 ESL07940.1 - 0.03 13.3 0.0 0.076 11.9 0.0 1.6 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family GAF_3 PF13492.1 ESL07940.1 - 0.081 13.0 0.4 23 5.0 0.0 3.5 4 0 0 4 4 4 0 GAF domain Ras PF00071.17 ESL07941.1 - 1.5e-09 37.4 0.0 3e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 ESL07941.1 - 0.00075 18.7 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESL07941.1 - 0.0014 19.0 0.0 0.0029 18.0 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein IBR PF01485.16 ESL07941.1 - 0.004 16.9 0.1 0.0094 15.8 0.1 1.5 1 0 0 1 1 1 1 IBR domain MMR_HSR1 PF01926.18 ESL07941.1 - 0.22 11.5 0.0 0.46 10.4 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase EXOSC1 PF10447.4 ESL07942.1 - 0.001 18.9 0.2 0.042 13.8 0.0 3.0 2 1 1 3 3 3 1 Exosome component EXOSC1/CSL4 DUF1937 PF09152.5 ESL07945.1 - 0.028 14.9 0.1 11 6.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1937) Ribosomal_L13 PF00572.13 ESL07946.1 - 1.3e-20 73.7 1.2 1.7e-20 73.3 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L13 TP53IP5 PF15331.1 ESL07946.1 - 0.11 12.4 3.3 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 SelR PF01641.13 ESL07948.1 - 1.9e-36 124.4 0.0 2.9e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 SelR domain GATA PF00320.22 ESL07948.1 - 0.00098 18.4 0.6 1.6 8.0 0.0 2.8 2 0 0 2 2 2 2 GATA zinc finger Endonuclease_7 PF02945.10 ESL07948.1 - 0.15 11.7 3.3 0.55 9.9 2.3 1.9 1 1 0 1 1 1 0 Recombination endonuclease VII zf-UBR PF02207.15 ESL07948.1 - 0.35 10.6 7.8 0.31 10.7 0.4 3.1 3 0 0 3 3 3 0 Putative zinc finger in N-recognin (UBR box) DZR PF12773.2 ESL07948.1 - 0.63 9.9 4.4 6.6 6.6 3.1 2.5 1 1 0 1 1 1 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.1 ESL07948.1 - 0.79 10.1 3.5 35 4.9 1.3 2.6 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Wyosine_form PF08608.7 ESL07949.1 - 2.7e-16 59.3 0.0 4.4e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Wyosine base formation DSPc PF00782.15 ESL07950.1 - 1e-28 99.5 0.0 2e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL07950.1 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Mito_carr PF00153.22 ESL07951.1 - 1.9e-30 104.4 2.8 1.1e-15 57.1 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein AAA_17 PF13207.1 ESL07952.1 - 6.8e-07 30.1 0.0 1.7e-06 28.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 ESL07952.1 - 4.2e-06 26.4 0.0 0.0013 18.3 0.0 2.2 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 ESL07952.1 - 0.00039 20.7 0.0 0.00079 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.7 ESL07952.1 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.1 ESL07952.1 - 0.015 15.1 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESL07952.1 - 0.07 13.2 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESL07952.1 - 0.079 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MobB PF03205.9 ESL07952.1 - 0.18 11.5 0.0 0.4 10.3 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B WD40 PF00400.27 ESL07953.1 - 1.2e-14 53.5 7.9 6.5e-06 25.8 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat 5-FTHF_cyc-lig PF01812.15 ESL07954.1 - 8e-17 61.6 0.2 1.8e-14 53.9 0.2 2.2 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family PSI PF01437.20 ESL07955.1 - 0.0028 17.7 4.9 0.0028 17.7 3.4 3.7 4 1 0 4 4 4 1 Plexin repeat Pex14_N PF04695.8 ESL07955.1 - 0.0056 16.7 0.4 0.012 15.6 0.1 1.7 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2371 PF10177.4 ESL07955.1 - 1.1 9.1 8.3 5.9 6.7 0.0 3.2 3 1 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) RR_TM4-6 PF06459.7 ESL07955.1 - 2.1 8.1 4.4 3.6 7.4 3.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Proteasome PF00227.21 ESL07957.1 - 5e-30 104.1 0.0 6.4e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Tfb2 PF03849.9 ESL07959.1 - 1.1e-25 90.1 0.0 1.5e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 ESL07959.1 - 0.00019 21.1 0.1 0.00065 19.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Miro PF08477.8 ESL07960.1 - 2.7e-05 24.6 0.0 0.00014 22.3 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein ABC_tran PF00005.22 ESL07960.1 - 0.0052 17.0 0.0 0.027 14.7 0.0 2.0 2 0 0 2 2 2 1 ABC transporter DLIC PF05783.6 ESL07960.1 - 0.017 13.8 0.1 0.04 12.5 0.0 1.7 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) FtsK_SpoIIIE PF01580.13 ESL07960.1 - 0.019 14.4 0.1 0.06 12.8 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESL07960.1 - 0.02 15.0 0.1 0.25 11.5 0.1 2.4 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESL07960.1 - 0.021 14.0 0.1 0.046 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESL07960.1 - 0.035 14.0 0.1 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Sigma54_activat PF00158.21 ESL07960.1 - 0.092 12.2 0.0 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Pox_A32 PF04665.7 ESL07960.1 - 0.11 11.7 0.0 0.25 10.6 0.0 1.6 1 0 0 1 1 1 0 Poxvirus A32 protein SRPRB PF09439.5 ESL07960.1 - 0.14 11.3 0.0 0.14 11.3 0.0 2.4 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit zf-C3HC4_3 PF13920.1 ESL07961.1 - 0.00012 21.6 6.5 0.00017 21.2 4.5 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C2HC5 PF06221.8 ESL07961.1 - 0.0055 16.4 4.5 0.0055 16.4 3.1 1.6 1 1 1 2 2 2 1 Putative zinc finger motif, C2HC5-type zf-RING_5 PF14634.1 ESL07961.1 - 0.0077 15.9 7.6 0.011 15.4 5.2 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESL07961.1 - 0.46 10.5 7.7 0.96 9.5 5.3 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL07961.1 - 1.3 8.9 11.5 4.2 7.2 7.9 1.8 1 1 0 1 1 1 0 Ring finger domain TerY-C PF15616.1 ESL07961.1 - 1.8 8.4 6.8 5 7.0 4.8 1.6 1 1 1 2 2 2 0 TerY-C metal binding domain FANCL_C PF11793.3 ESL07961.1 - 4 7.4 8.3 4.6 7.2 0.2 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain UPF0506 PF11703.3 ESL07961.1 - 6.9 6.7 9.4 0.91 9.5 3.5 1.7 1 1 1 2 2 2 0 UPF0506 Ras PF00071.17 ESL07963.1 - 5.7e-09 35.5 0.0 0.0028 17.0 0.0 2.9 3 0 0 3 3 3 2 Ras family Miro PF08477.8 ESL07963.1 - 6.7e-06 26.5 0.0 0.013 16.0 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein Arf PF00025.16 ESL07963.1 - 0.0011 18.2 0.0 1.6 7.9 0.0 2.6 3 0 0 3 3 3 2 ADP-ribosylation factor family Tubulin PF00091.20 ESL07964.1 - 8.7e-73 244.7 0.0 1.3e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESL07964.1 - 1.1e-44 151.5 0.2 1.1e-44 151.5 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESL07964.1 - 1.3e-05 25.2 0.0 4.5e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.1 ESL07964.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Metallophos PF00149.23 ESL07965.1 - 6.1e-40 136.7 0.7 7.5e-40 136.4 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SNARE PF05739.14 ESL07966.1 - 3.1e-06 26.7 0.0 4.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 SNARE domain DUF3375 PF11855.3 ESL07966.1 - 0.063 12.0 2.4 0.08 11.6 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) SIMPL PF04402.9 ESL07966.1 - 0.17 11.7 0.5 0.37 10.6 0.2 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF541) Plasmid_stab_B PF10784.4 ESL07966.1 - 0.45 10.1 2.5 1 8.9 0.2 2.0 2 0 0 2 2 2 0 Plasmid stability protein DUF3618 PF12277.3 ESL07966.1 - 2.8 8.0 7.0 0.38 10.8 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3618) DNA_ligase_OB_2 PF14743.1 ESL07967.1 - 9.3e-21 73.2 0.3 1.6e-20 72.5 0.2 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.16 ESL07967.1 - 1.4e-15 57.1 0.0 2.2e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DUF4379 PF14311.1 ESL07967.1 - 2.4e-13 49.6 4.3 4.9e-13 48.6 2.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) PseudoU_synth_2 PF00849.17 ESL07969.1 - 5.8e-19 68.5 0.1 5.5e-09 36.0 0.0 2.3 2 0 0 2 2 2 2 RNA pseudouridylate synthase PEX11 PF05648.9 ESL07970.1 - 0.0067 15.7 0.1 0.0075 15.5 0.1 1.3 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DEAD PF00270.24 ESL07971.1 - 6.7e-43 146.1 0.0 3e-42 143.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL07971.1 - 2.5e-26 91.3 0.2 9.4e-26 89.4 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bac_surface_Ag PF01103.18 ESL07972.1 - 1.3e-17 64.3 0.6 1.9e-17 63.7 0.4 1.3 1 0 0 1 1 1 1 Surface antigen Surf_Ag_VNR PF07244.10 ESL07972.1 - 0.12 12.8 0.0 0.48 10.8 0.0 2.1 2 1 0 2 2 2 0 Surface antigen variable number repeat Cpn60_TCP1 PF00118.19 ESL07973.1 - 2.7e-55 187.9 1.0 3e-55 187.7 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HAD_2 PF13419.1 ESL07976.1 - 3.9e-06 27.2 0.0 0.00011 22.4 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESL07976.1 - 0.00025 20.6 0.0 0.00045 19.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DZR PF12773.2 ESL07977.1 - 0.0029 17.3 0.3 0.0084 15.9 0.2 1.8 1 0 0 1 1 1 1 Double zinc ribbon zf-RanBP PF00641.13 ESL07977.1 - 0.016 14.3 1.6 0.037 13.1 1.1 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Clat_adaptor_s PF01217.15 ESL07980.1 - 5e-42 142.9 0.5 5.6e-42 142.8 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PMP22_Claudin PF00822.15 ESL07981.1 - 1.1e-05 25.2 9.1 1.4e-05 24.7 6.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Amastin PF07344.6 ESL07981.1 - 5.3e-05 22.8 19.4 7.5e-05 22.3 11.2 2.0 1 1 1 2 2 2 1 Amastin surface glycoprotein Claudin_2 PF13903.1 ESL07981.1 - 0.0029 17.3 10.7 0.0029 17.3 7.4 2.0 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction LRR19-TM PF15176.1 ESL07981.1 - 2.2 8.0 4.2 6.1 6.6 0.0 2.5 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF3040 PF11239.3 ESL07981.1 - 4.3 7.4 6.8 0.37 10.8 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) zf-RING_2 PF13639.1 ESL07982.1 - 8.6e-12 44.7 5.7 8.6e-12 44.7 4.0 2.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESL07982.1 - 2.8e-07 30.0 5.5 5.4e-07 29.1 2.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL07982.1 - 4.2e-07 29.5 2.6 4.2e-07 29.5 1.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 ESL07982.1 - 4.6e-07 29.8 3.8 4.6e-07 29.8 2.6 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESL07982.1 - 6.5e-07 29.2 5.1 6.5e-07 29.2 3.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL07982.1 - 9.2e-07 28.6 1.8 2.3e-06 27.3 1.3 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 ESL07982.1 - 0.00018 21.0 3.7 0.00018 21.0 2.5 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 ESL07982.1 - 0.00051 19.4 1.4 0.00086 18.7 0.3 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.6 ESL07982.1 - 0.00091 19.1 3.1 0.0036 17.2 2.1 2.1 1 0 0 1 1 1 1 RING-like domain zf-RING_4 PF14570.1 ESL07982.1 - 0.0033 16.9 5.6 0.022 14.3 2.1 2.7 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain PHD PF00628.24 ESL07982.1 - 0.0042 16.7 4.5 0.013 15.1 3.1 1.9 1 0 0 1 1 1 1 PHD-finger zf-RING_UBOX PF13445.1 ESL07982.1 - 0.061 13.0 3.7 0.091 12.5 0.5 2.6 2 1 1 3 3 2 0 RING-type zinc-finger Flexi_CP PF00286.15 ESL07982.1 - 0.063 12.9 0.2 0.12 12.1 0.1 1.6 1 1 0 1 1 1 0 Viral coat protein zf-HC5HC2H PF13771.1 ESL07982.1 - 0.16 12.1 3.3 0.53 10.4 2.3 1.9 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C3HC4_4 PF15227.1 ESL07982.1 - 0.35 10.7 7.9 1.4 8.8 3.6 2.8 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 ESL07982.1 - 0.42 10.4 6.5 0.2 11.4 2.4 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-P11 PF03854.9 ESL07982.1 - 0.78 9.2 10.1 0.39 10.2 3.2 2.9 2 1 1 3 3 2 0 P-11 zinc finger Prok-RING_1 PF14446.1 ESL07982.1 - 3.6 7.4 9.7 0.39 10.4 1.8 2.6 2 1 1 3 3 2 0 Prokaryotic RING finger family 1 N_Asn_amidohyd PF14736.1 ESL07985.1 - 0.11 11.3 0.0 0.72 8.6 0.0 2.3 4 0 0 4 4 4 0 Protein N-terminal asparagine amidohydrolase Pyr_redox_2 PF07992.9 ESL07986.1 - 7.9e-23 81.3 0.1 1.1e-22 80.8 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESL07986.1 - 1.1e-20 73.8 0.3 3.2e-16 59.4 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESL07986.1 - 2e-13 50.3 0.0 3.7e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.1 ESL07986.1 - 2.4e-10 40.8 0.5 4.1e-05 23.7 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESL07986.1 - 5.4e-10 38.9 0.5 5.4e-10 38.9 0.3 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 ESL07986.1 - 3.2e-07 29.5 0.2 0.00015 20.7 0.1 2.8 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESL07986.1 - 6.9e-07 29.1 1.6 0.0018 18.2 0.0 3.4 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 ESL07986.1 - 1.5e-06 26.9 1.6 0.00074 18.1 0.3 3.1 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.19 ESL07986.1 - 1.4e-05 24.2 7.7 0.00073 18.5 0.6 3.8 3 1 1 4 4 4 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESL07986.1 - 0.00024 20.0 5.0 0.00061 18.7 0.4 3.0 3 0 0 3 3 3 1 FAD binding domain ThiF PF00899.16 ESL07986.1 - 0.0017 18.1 0.1 0.0045 16.8 0.1 1.7 1 0 0 1 1 1 1 ThiF family Lycopene_cycl PF05834.7 ESL07986.1 - 0.0021 17.0 0.1 0.16 10.8 0.0 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.12 ESL07986.1 - 0.0024 16.9 0.0 0.029 13.4 0.0 2.3 2 0 0 2 2 2 1 Thi4 family ApbA PF02558.11 ESL07986.1 - 0.013 14.9 0.0 0.035 13.5 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.14 ESL07986.1 - 0.025 13.6 2.9 0.13 11.3 0.0 2.7 3 0 0 3 3 3 0 FAD binding domain 3HCDH_N PF02737.13 ESL07986.1 - 0.046 13.3 0.0 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 ESL07986.1 - 0.052 13.8 0.0 3.1 8.1 0.0 2.5 2 0 0 2 2 2 0 XdhC Rossmann domain Glyco_trans_1_3 PF13528.1 ESL07986.1 - 0.13 11.4 0.1 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 1 PC_rep PF01851.17 ESL07987.1 - 1e-07 31.7 0.4 1.6e-05 24.8 0.0 3.0 2 0 0 2 2 2 2 Proteasome/cyclosome repeat TPR_5 PF12688.2 ESL07987.1 - 0.092 12.7 0.4 0.2 11.7 0.2 1.6 1 1 0 1 1 1 0 Tetratrico peptide repeat GDPD PF03009.12 ESL07988.1 - 3.1e-21 76.0 0.0 4.1e-21 75.6 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.14 ESL07988.1 - 0.045 13.1 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Pkinase PF00069.20 ESL07989.1 - 6.3e-73 245.1 0.0 7.3e-73 244.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL07989.1 - 1.1e-31 109.9 0.0 1.4e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL07989.1 - 0.00063 19.5 0.1 0.22 11.2 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESL07989.1 - 0.037 12.8 0.0 0.058 12.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 ESL07989.1 - 0.073 12.1 0.1 0.18 10.8 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.27 ESL07990.1 - 1.1e-52 174.1 20.1 7.9e-11 41.4 0.0 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESL07990.1 - 1.1e-10 40.9 0.0 3.8e-10 39.1 0.0 1.8 2 0 0 2 2 2 1 Coatomer WD associated region Nup160 PF11715.3 ESL07990.1 - 0.023 12.8 8.5 0.96 7.5 0.2 4.1 2 2 3 5 5 5 0 Nucleoporin Nup120/160 His_Phos_2 PF00328.17 ESL07991.1 - 4.9e-09 35.9 0.0 6.6e-08 32.2 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Aminotran_4 PF01063.14 ESL07992.1 - 7.7e-26 90.9 0.0 1e-25 90.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV AAA PF00004.24 ESL07993.1 - 1.5e-05 25.2 3.1 0.0002 21.5 0.2 3.5 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL07993.1 - 0.00012 22.9 0.0 0.00048 20.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL07993.1 - 0.00028 20.9 0.1 0.00083 19.3 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 ESL07993.1 - 0.02 14.8 0.0 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 ESL07993.1 - 0.025 14.2 0.0 0.1 12.2 0.0 2.0 2 1 0 2 2 2 0 Archaeal ATPase AAA_22 PF13401.1 ESL07993.1 - 0.099 12.7 0.0 1.3 9.1 0.0 2.7 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.10 ESL07993.1 - 0.29 9.7 0.0 0.89 8.1 0.0 1.6 1 1 1 2 2 2 0 Rad17 cell cycle checkpoint protein Hydrolase_like2 PF13246.1 ESL07994.1 - 2.9e-08 33.5 0.0 9.7e-08 31.8 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 ESL07994.1 - 1.7e-07 31.8 0.0 4.3e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL07994.1 - 8.9e-07 29.2 0.0 1.5e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL07994.1 - 0.0018 17.9 0.0 0.0045 16.5 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase zf-C2HC_2 PF13913.1 ESL07995.1 - 2.3e-43 145.0 48.1 5.9e-10 38.5 0.9 8.3 8 0 0 8 8 8 6 zinc-finger of a C2HC-type zinc_ribbon_2 PF13240.1 ESL07995.1 - 8.6e-17 60.0 44.4 1.6e-05 24.1 1.8 8.2 8 0 0 8 8 8 5 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESL07995.1 - 9.3e-17 59.6 44.7 2.8e-05 23.1 0.7 8.2 9 0 0 9 9 9 5 zinc-ribbon domain DZR PF12773.2 ESL07995.1 - 2.5e-14 52.7 47.4 5.1e-09 35.8 6.3 8.0 6 3 0 6 6 6 4 Double zinc ribbon Sgf11 PF08209.6 ESL07995.1 - 2.2e-05 23.6 40.2 0.029 13.6 0.8 7.3 8 0 0 8 8 8 5 Sgf11 (transcriptional regulation protein) NOB1_Zn_bind PF08772.6 ESL07995.1 - 0.005 16.6 0.1 0.005 16.6 0.1 5.9 5 1 1 6 6 6 2 Nin one binding (NOB1) Zn-ribbon like zf-C2H2 PF00096.21 ESL07995.1 - 0.0083 16.4 0.1 0.0083 16.4 0.1 9.1 11 0 0 11 11 11 4 Zinc finger, C2H2 type Cript PF10235.4 ESL07995.1 - 0.012 15.9 18.8 0.2 12.0 0.2 5.7 5 1 1 6 6 6 0 Microtubule-associated protein CRIPT Rad50_zn_hook PF04423.9 ESL07995.1 - 0.17 11.3 14.5 2.8 7.4 0.2 5.3 5 0 0 5 5 5 0 Rad50 zinc hook motif Evr1_Alr PF04777.8 ESL07995.1 - 1.5 8.7 8.7 13 5.7 0.0 4.9 4 1 0 4 4 4 0 Erv1 / Alr family SET PF00856.23 ESL07996.1 - 2e-05 24.9 0.0 0.0012 19.1 0.0 2.4 1 1 0 1 1 1 1 SET domain SR-25 PF10500.4 ESL07996.1 - 0.15 11.5 4.1 0.23 10.8 2.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UL73_N PF12522.3 ESL07996.1 - 9.2 5.9 17.4 0.059 12.9 6.2 1.7 2 0 0 2 2 2 0 Cytomegalovirus glycoprotein N terminal PIP5K PF01504.13 ESL07998.1 - 1.5e-59 201.1 0.0 3.3e-59 200.0 0.0 1.5 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Daxx PF03344.10 ESL07998.1 - 0.011 14.2 1.4 0.018 13.5 1.0 1.2 1 0 0 1 1 1 0 Daxx Family Auxin_repressed PF05564.7 ESL07998.1 - 0.015 15.8 0.5 0.34 11.5 0.2 2.7 2 0 0 2 2 2 0 Dormancy/auxin associated protein VID27 PF08553.5 ESL07998.1 - 0.71 8.0 3.9 0.95 7.6 2.7 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein PBP_sp32 PF07222.7 ESL07998.1 - 0.81 8.8 7.4 0.15 11.2 2.5 1.7 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Proteasome PF00227.21 ESL07999.1 - 5.8e-50 169.2 0.4 7.4e-50 168.8 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.27 ESL08000.1 - 5.9e-14 51.3 3.3 7.9e-05 22.3 0.0 5.6 6 1 0 6 6 6 3 WD domain, G-beta repeat L71 PF02448.10 ESL08000.1 - 0.084 12.7 1.1 0.23 11.3 0.2 2.1 2 0 0 2 2 2 0 L71 family MFS_1 PF07690.11 ESL08001.1 - 5.5e-09 35.1 42.7 5.5e-09 35.1 29.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily IQ PF00612.22 ESL08002.1 - 2.2e-09 36.0 19.0 0.00065 19.1 1.5 4.1 3 0 0 3 3 3 3 IQ calmodulin-binding motif Lactamase_B_2 PF12706.2 ESL08003.1 - 1.2e-35 122.8 0.1 2.1e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESL08003.1 - 0.001 18.7 0.0 0.0063 16.1 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.1 ESL08003.1 - 0.0048 16.3 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 tRNase Z endonuclease Sulfate_transp PF00916.15 ESL08004.1 - 1.1e-33 116.4 7.9 3.1e-33 114.9 5.5 1.8 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 ESL08004.1 - 2.3e-15 56.0 3.1 2.3e-15 56.0 2.1 3.4 5 0 0 5 5 5 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 ESL08004.1 - 0.0013 18.1 0.0 0.0031 16.9 0.0 1.6 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 ESL08004.1 - 0.098 12.7 0.6 2.8 8.0 0.0 2.6 2 0 0 2 2 2 0 STAS domain SKI PF01202.17 ESL08005.1 - 1.3e-11 44.6 0.0 1.6e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.1 ESL08005.1 - 5.7e-08 32.7 0.0 7.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL08005.1 - 7.5e-08 33.2 0.0 9.5e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL08005.1 - 0.00017 21.8 0.0 0.00026 21.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESL08005.1 - 0.0012 19.0 0.0 0.0032 17.6 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL08005.1 - 0.0018 18.3 0.3 0.0051 16.8 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 ESL08005.1 - 0.0023 17.9 0.0 0.0042 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL08005.1 - 0.0064 15.6 0.0 0.0099 14.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 ESL08005.1 - 0.0069 16.5 0.0 0.013 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESL08005.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 RNA helicase DUF258 PF03193.11 ESL08005.1 - 0.027 13.6 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESL08005.1 - 0.036 14.3 0.0 0.054 13.7 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.9 ESL08005.1 - 0.043 13.5 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 ESL08005.1 - 0.059 12.3 0.0 0.082 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 ESL08005.1 - 0.059 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 ESL08005.1 - 0.091 12.5 0.1 0.84 9.4 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_25 PF13481.1 ESL08005.1 - 0.1 11.9 0.0 0.2 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESL08005.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 ESL08005.1 - 0.14 11.6 0.2 0.46 9.9 0.1 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family PRK PF00485.13 ESL08005.1 - 0.14 11.6 0.1 0.44 10.0 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.15 ESL08005.1 - 0.15 11.7 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase KOW PF00467.24 ESL08006.1 - 3.1e-06 26.6 0.6 3.1e-06 26.6 0.4 2.3 2 2 0 2 2 2 1 KOW motif START PF01852.14 ESL08010.1 - 9.3e-11 41.4 0.0 1.9e-10 40.3 0.0 1.4 1 1 0 1 1 1 1 START domain Rabaptin PF03528.10 ESL08011.1 - 1.7 8.5 12.0 0.036 13.9 1.4 3.0 2 1 1 3 3 3 0 Rabaptin TylF PF05711.6 ESL08012.1 - 9.7e-19 67.4 0.0 1.5e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 ESL08012.1 - 9.6e-08 32.8 0.1 5.9e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain CmcI PF04989.7 ESL08012.1 - 0.0023 17.2 0.0 0.0062 15.8 0.0 1.8 2 0 0 2 2 2 1 Cephalosporin hydroxylase ApbE PF02424.10 ESL08013.1 - 0.05 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 ApbE family TPR_11 PF13414.1 ESL08014.1 - 1.3e-27 95.1 16.2 5e-13 48.4 1.4 5.2 3 2 2 5 5 5 3 TPR repeat TPR_1 PF00515.23 ESL08014.1 - 1.8e-18 65.2 8.5 0.00022 20.6 0.1 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08014.1 - 2.7e-17 61.1 13.4 2.2e-05 24.0 0.0 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat DnaJ PF00226.26 ESL08014.1 - 1.7e-14 53.2 0.0 4.6e-14 51.8 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_17 PF13431.1 ESL08014.1 - 7.9e-09 35.0 7.0 0.0037 17.3 0.2 5.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08014.1 - 2e-08 33.3 1.7 0.019 14.7 0.0 4.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL08014.1 - 7.9e-06 26.0 10.3 0.067 13.8 0.1 5.9 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL08014.1 - 0.00028 21.4 0.2 0.0024 18.5 0.1 5.9 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESL08014.1 - 0.00083 19.1 12.0 0.73 9.7 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL08014.1 - 0.0018 18.5 8.6 0.0068 16.7 0.2 4.9 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08014.1 - 0.0024 17.5 5.4 0.39 10.6 0.0 4.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08014.1 - 0.0082 16.5 3.7 6.4 7.4 0.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat adh_short PF00106.20 ESL08015.1 - 1.4e-20 73.8 0.0 1.9e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESL08015.1 - 7.1e-12 45.6 0.0 1.1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESL08015.1 - 2.6e-06 27.2 0.0 4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 ESL08015.1 - 0.0011 18.7 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1776 PF08643.5 ESL08015.1 - 0.022 13.8 0.1 0.12 11.5 0.0 1.9 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.1 ESL08015.1 - 0.04 13.9 0.1 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 ESL08015.1 - 0.045 12.6 0.1 0.061 12.2 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Glyco_hydro_3 PF00933.16 ESL08015.1 - 0.055 12.4 0.0 0.09 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 N terminal domain Epimerase PF01370.16 ESL08015.1 - 0.071 12.5 0.1 0.12 11.7 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF3646 PF12362.3 ESL08015.1 - 0.14 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal ELO PF01151.13 ESL08017.1 - 1.2e-72 244.2 11.5 1.4e-72 243.9 8.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Transmemb_17 PF09799.4 ESL08017.1 - 0.89 9.9 10.4 0.095 13.0 3.6 2.0 2 0 0 2 2 2 0 Predicted membrane protein SUI1 PF01253.17 ESL08018.1 - 8.8e-24 83.1 0.1 1.1e-23 82.8 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 RIP PF00161.14 ESL08018.1 - 0.0016 17.6 0.1 0.0021 17.2 0.1 1.1 1 0 0 1 1 1 1 Ribosome inactivating protein YcgR PF07317.7 ESL08018.1 - 0.072 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Flagellar regulator YcgR Ssl1 PF04056.9 ESL08019.1 - 1.4e-26 93.2 0.0 1.3e-12 47.7 0.0 2.1 2 0 0 2 2 2 2 Ssl1-like Tfb4 PF03850.9 ESL08019.1 - 0.006 15.8 0.0 0.0096 15.2 0.0 1.3 1 0 0 1 1 1 1 Transcription factor Tfb4 C1_4 PF07975.7 ESL08019.1 - 0.0078 16.2 7.4 0.0078 16.2 5.2 2.5 2 1 0 2 2 2 1 TFIIH C1-like domain Abhydrolase_6 PF12697.2 ESL08020.1 - 2.2e-29 102.9 0.1 2.7e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL08020.1 - 7.1e-19 68.2 0.0 1.7e-18 67.0 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESL08020.1 - 2e-15 56.7 0.0 1.1e-14 54.4 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESL08020.1 - 9.6e-05 21.6 0.2 0.0011 18.2 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.13 ESL08020.1 - 0.0001 21.6 0.0 0.049 12.9 0.0 2.9 2 1 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 ESL08020.1 - 0.00034 20.1 0.0 0.0036 16.7 0.0 2.0 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Ndr PF03096.9 ESL08020.1 - 0.00057 18.4 0.0 0.00076 18.0 0.0 1.1 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.3 ESL08020.1 - 0.0012 18.5 0.0 0.006 16.4 0.0 2.1 2 0 0 2 2 2 1 Putative lysophospholipase FSH1 PF03959.8 ESL08020.1 - 0.0034 16.8 0.0 0.0044 16.4 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Esterase_phd PF10503.4 ESL08020.1 - 0.007 15.6 0.1 1 8.5 0.0 2.1 2 0 0 2 2 2 1 Esterase PHB depolymerase Abhydrolase_4 PF08386.5 ESL08020.1 - 0.077 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein DUF2048 PF09752.4 ESL08020.1 - 0.097 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) ELMO_CED12 PF04727.8 ESL08021.1 - 1.2e-43 148.6 0.4 1.8e-43 148.0 0.3 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family SAP18 PF06487.7 ESL08024.1 - 0.053 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) S-AdoMet_synt_C PF02773.11 ESL08025.1 - 9.7e-65 216.4 0.2 1.6e-64 215.7 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 ESL08025.1 - 1.7e-46 157.0 0.0 2e-45 153.6 0.0 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 ESL08025.1 - 4.3e-38 129.5 0.1 8e-38 128.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain GSH_synth_ATP PF03917.12 ESL08026.1 - 2.7e-63 213.8 0.0 4.6e-63 213.0 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 ESL08026.1 - 9.2e-35 118.9 0.0 1.7e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase WD40 PF00400.27 ESL08028.1 - 1.5e-34 116.6 23.5 6.3e-09 35.3 0.1 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat Sof1 PF04158.9 ESL08028.1 - 1.7e-11 43.9 6.3 3.1e-11 43.1 4.4 1.4 1 0 0 1 1 1 1 Sof1-like domain Nup160 PF11715.3 ESL08028.1 - 0.0024 16.0 2.4 0.12 10.5 0.0 2.7 2 1 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESL08028.1 - 0.011 14.4 1.0 0.65 8.6 0.1 2.7 1 1 1 2 2 2 0 Nup133 N terminal like ABC2_membrane PF01061.19 ESL08029.1 - 2.1e-05 23.8 15.1 2.1e-05 23.8 10.5 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESL08029.1 - 0.00021 21.6 0.1 0.0004 20.6 0.0 1.6 2 0 0 2 2 2 1 ABC transporter Pkinase PF00069.20 ESL08030.1 - 6.8e-40 136.8 0.0 9.7e-39 133.0 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08030.1 - 2.3e-20 72.7 0.0 2.7e-13 49.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESL08030.1 - 0.00078 19.2 0.0 0.011 15.5 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL08030.1 - 0.054 12.4 0.0 0.95 8.3 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RSS_P20 PF11757.3 ESL08030.1 - 0.12 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like FAD_binding_7 PF03441.9 ESL08031.1 - 1.7e-39 135.6 0.3 2.6e-39 135.0 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase Pkinase PF00069.20 ESL08033.1 - 3e-46 157.6 0.0 5.4e-35 120.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Beta_helix PF13229.1 ESL08033.1 - 1.3e-35 122.4 37.3 1.2e-17 64.1 4.9 3.7 1 1 2 3 3 3 3 Right handed beta helix region Pkinase_Tyr PF07714.12 ESL08033.1 - 1.5e-31 109.4 0.0 2e-25 89.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase NosD PF05048.8 ESL08033.1 - 4.9e-21 74.9 0.8 1.2e-10 41.0 0.1 2.3 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) Kinase-like PF14531.1 ESL08033.1 - 1.5e-06 27.4 0.0 1.9e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like zf-B_box PF00643.19 ESL08033.1 - 6.7e-06 25.8 7.0 6.7e-06 25.8 4.9 2.5 3 0 0 3 3 3 1 B-box zinc finger DUF1565 PF07602.6 ESL08033.1 - 4.2e-05 22.8 6.3 0.00017 20.8 3.4 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1565) APH PF01636.18 ESL08033.1 - 0.0038 16.9 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family UPF0147 PF03685.8 ESL08034.1 - 0.0077 16.0 0.0 0.03 14.1 0.0 2.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0147) KxDL PF10241.4 ESL08034.1 - 0.11 12.4 4.5 0.47 10.3 2.5 2.6 1 1 0 1 1 1 0 Uncharacterized conserved protein Cauli_AT PF03233.8 ESL08034.1 - 3 7.5 4.5 1.2 8.8 0.9 1.9 2 0 0 2 2 2 0 Aphid transmission protein FliD_C PF07195.7 ESL08034.1 - 6.3 6.0 11.3 3.3 6.9 1.4 3.0 2 2 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus WD40 PF00400.27 ESL08035.1 - 2.1e-15 55.9 0.2 1.4e-05 24.7 0.0 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESL08035.1 - 0.0058 16.1 0.0 4.3 6.9 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Sec1 PF00995.18 ESL08037.1 - 7.3e-92 308.8 0.4 9.1e-92 308.4 0.3 1.0 1 0 0 1 1 1 1 Sec1 family Methyltransf_18 PF12847.2 ESL08038.1 - 9.4e-11 42.2 0.0 1.5e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL08038.1 - 2.6e-10 40.6 0.0 4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL08038.1 - 5.6e-10 39.0 0.0 7.2e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL08038.1 - 2.2e-08 34.4 0.0 3.7e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESL08038.1 - 4.8e-06 26.1 0.0 1.2e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 Nodulation protein S (NodS) TPMT PF05724.6 ESL08038.1 - 1.2e-05 24.8 0.0 2.1e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.1 ESL08038.1 - 1.7e-05 24.5 0.0 3.9e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL08038.1 - 0.00046 20.5 0.0 0.00099 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESL08038.1 - 0.00068 19.3 0.0 1 8.9 0.0 2.1 2 0 0 2 2 2 2 Hypothetical methyltransferase Pox_MCEL PF03291.11 ESL08038.1 - 0.0039 16.1 0.0 0.0052 15.6 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_32 PF13679.1 ESL08038.1 - 0.0089 15.7 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL08038.1 - 0.013 14.8 0.0 0.029 13.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_26 PF13659.1 ESL08038.1 - 0.014 15.4 0.0 0.1 12.6 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 ESL08038.1 - 0.015 14.4 0.0 0.028 13.5 0.0 1.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family TehB PF03848.9 ESL08038.1 - 0.043 12.9 0.0 0.081 12.0 0.0 1.4 1 1 0 1 1 1 0 Tellurite resistance protein TehB RrnaAD PF00398.15 ESL08038.1 - 0.059 12.3 0.0 0.078 11.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase SHS2_Rpb7-N PF03876.12 ESL08039.1 - 1.8e-26 92.0 0.0 3.2e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.7 ESL08039.1 - 3.7e-24 85.2 0.0 5.8e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Acyltransferase PF01553.16 ESL08040.1 - 6.2e-14 51.5 0.0 2.9e-13 49.3 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase PRP21_like_P PF12230.3 ESL08040.1 - 0.0056 16.2 0.6 0.0089 15.5 0.4 1.2 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Beta-Casp PF10996.3 ESL08042.1 - 5.3e-32 110.4 0.0 1.2e-31 109.3 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 ESL08042.1 - 2e-17 63.5 0.0 3.9e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESL08042.1 - 5.1e-10 39.2 0.1 1.3e-09 37.8 0.1 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 ESL08042.1 - 1.6e-09 37.4 0.1 3.3e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase CPSF73-100_C PF11718.3 ESL08042.1 - 3.2e-09 36.4 0.1 1.1e-08 34.7 0.0 1.8 1 1 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_3 PF13483.1 ESL08042.1 - 0.0017 18.0 0.0 0.0098 15.6 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain DUF3701 PF12482.3 ESL08045.1 - 0.087 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Phage integrase protein Shisa PF13908.1 ESL08045.1 - 0.11 12.6 0.1 0.42 10.7 0.0 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Papilloma_E5A PF05776.7 ESL08045.1 - 2 8.6 6.0 3.1 7.9 4.1 1.3 1 0 0 1 1 1 0 Papillomavirus E5A protein PepSY_TM PF03929.11 ESL08045.1 - 3.6 8.1 5.0 7 7.2 3.5 1.5 1 0 0 1 1 1 0 PepSY-associated TM helix Jnk-SapK_ap_N PF09744.4 ESL08046.1 - 0.043 13.8 7.9 0.14 12.1 0.1 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4051 PF13260.1 ESL08046.1 - 0.21 10.9 1.3 2.7 7.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) Isochorismatase PF00857.15 ESL08047.1 - 1.6e-23 83.5 0.0 1.9e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family WD40 PF00400.27 ESL08049.1 - 1.6e-58 192.6 24.8 5e-11 42.0 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESL08049.1 - 0.00071 17.8 5.8 0.65 8.0 4.0 3.0 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Cluap1 PF10234.4 ESL08049.1 - 0.011 15.0 7.6 0.017 14.3 5.2 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 DASH_Spc34 PF08657.5 ESL08049.1 - 0.014 15.1 4.5 0.021 14.4 3.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Spc34 Taxilin PF09728.4 ESL08049.1 - 0.041 12.9 12.0 0.069 12.2 8.3 1.3 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DUF3312 PF11768.3 ESL08049.1 - 0.045 11.9 0.3 0.67 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) Tropomyosin PF00261.15 ESL08049.1 - 0.084 11.9 14.2 0.17 10.9 9.5 1.5 1 1 0 1 1 1 0 Tropomyosin FmdE PF02663.9 ESL08049.1 - 0.13 12.1 1.2 0.4 10.5 0.1 2.3 2 0 0 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Phage_GPO PF05929.6 ESL08049.1 - 0.53 9.4 4.2 0.87 8.7 2.9 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FlxA PF14282.1 ESL08049.1 - 1.8 8.5 9.1 6.7 6.7 2.5 2.3 1 1 1 2 2 2 0 FlxA-like protein DUF3584 PF12128.3 ESL08049.1 - 2 5.6 14.5 2.7 5.1 10.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) V_ATPase_I PF01496.14 ESL08049.1 - 2 6.1 7.9 2.9 5.6 5.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TBPIP PF07106.8 ESL08049.1 - 3.7 7.0 9.6 9.9 5.6 6.7 1.6 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 ESL08049.1 - 5.7 7.3 8.6 1.9 8.8 3.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) PIG-S PF10510.4 ESL08050.1 - 0.00064 18.5 0.4 0.0023 16.6 0.3 1.8 1 1 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein 7tm_1 PF00001.16 ESL08050.1 - 0.1 11.7 0.4 0.54 9.3 0.0 2.0 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Leu_zip PF15294.1 ESL08051.1 - 4.6e-09 35.7 10.7 0.00025 20.2 5.6 2.3 1 1 1 2 2 2 2 Leucine zipper CorA PF01544.13 ESL08051.1 - 0.072 12.1 1.9 1.1 8.2 0.0 2.7 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein FlaC_arch PF05377.6 ESL08051.1 - 0.15 11.9 1.2 4.6 7.2 0.1 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Rab5-bind PF09311.6 ESL08051.1 - 0.53 10.1 9.5 4.7 7.0 2.1 2.3 1 1 1 2 2 2 0 Rabaptin-like protein RBD-FIP PF09457.5 ESL08051.1 - 0.67 9.7 6.1 1.6 8.5 0.3 3.3 4 0 0 4 4 4 0 FIP domain Cep57_CLD_2 PF14197.1 ESL08051.1 - 1.4 8.8 7.5 0.66 9.9 0.4 2.9 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Syntaxin PF00804.20 ESL08051.1 - 1.9 8.7 8.3 2.1 8.5 4.5 2.0 2 1 0 2 2 2 0 Syntaxin CENP-Q PF13094.1 ESL08051.1 - 2.4 8.1 11.6 14 5.7 8.0 2.1 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Fez1 PF06818.10 ESL08051.1 - 3.6 7.5 11.2 6.2 6.7 6.2 2.2 2 1 1 3 3 3 0 Fez1 Apolipoprotein PF01442.13 ESL08051.1 - 6.2 6.2 14.8 14 5.1 7.7 2.5 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Toprim_3 PF13362.1 ESL08051.1 - 6.7 7.0 8.5 1.5 9.1 0.9 2.7 2 1 1 3 3 3 0 Toprim domain SlyX PF04102.7 ESL08051.1 - 8 6.9 9.4 2.4 8.6 0.4 3.0 2 1 0 2 2 2 0 SlyX HisKA_3 PF07730.8 ESL08051.1 - 9.2 6.6 13.1 0.24 11.7 0.3 3.8 3 2 0 3 3 3 0 Histidine kinase NAD_Gly3P_dh_N PF01210.18 ESL08052.1 - 1.7e-06 27.8 0.0 1.9e-05 24.4 0.0 2.3 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 ESL08052.1 - 0.019 14.7 0.0 0.052 13.2 0.0 1.7 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus ApbA PF02558.11 ESL08052.1 - 0.042 13.2 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DEAD PF00270.24 ESL08053.1 - 2.1e-41 141.2 0.2 4e-41 140.3 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL08053.1 - 6.1e-23 80.4 0.0 9.9e-22 76.6 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UMPH-1 PF05822.7 ESL08053.1 - 0.055 12.7 1.7 0.14 11.4 0.0 2.0 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) XRN_N PF03159.13 ESL08055.1 - 0.09 12.1 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Apc3 PF12895.2 ESL08056.1 - 0.0073 16.4 1.9 0.61 10.2 0.1 3.1 2 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESL08056.1 - 0.22 11.8 6.7 0.29 11.5 0.4 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL08056.1 - 0.52 11.1 8.0 3.6 8.4 0.2 4.7 3 1 2 5 5 5 0 Tetratricopeptide repeat TRAP_alpha PF03896.11 ESL08057.1 - 4.4e-15 55.4 0.1 5.1e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF4106 PF13388.1 ESL08058.1 - 0.57 9.0 2.8 0.9 8.4 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) DOT1 PF08123.8 ESL08059.1 - 7e-23 81.0 0.0 9.7e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 ESL08059.1 - 9.3e-07 29.4 0.0 1.4e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL08059.1 - 1.1e-06 28.3 0.0 2.8e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL08059.1 - 1.1e-05 25.7 0.0 0.0007 20.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL08059.1 - 0.00018 21.5 0.0 0.00032 20.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL08059.1 - 0.0015 18.9 0.0 0.0029 17.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESL08059.1 - 0.012 14.7 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 ESL08059.1 - 0.021 15.2 0.0 0.054 13.9 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_4 PF02390.12 ESL08059.1 - 0.038 13.0 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase MetW PF07021.7 ESL08059.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.8 ESL08059.1 - 0.091 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_9 PF08003.6 ESL08059.1 - 0.094 11.3 0.1 1.3 7.6 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) Ribosomal_L12 PF00542.14 ESL08060.1 - 3.6e-16 58.9 0.8 5.4e-16 58.3 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Bac_DNA_binding PF00216.16 ESL08060.1 - 0.091 12.7 0.2 14 5.8 0.2 2.2 2 0 0 2 2 2 0 Bacterial DNA-binding protein Trichoplein PF13868.1 ESL08061.1 - 1.7e-11 43.1 129.7 1.7e-11 43.1 89.9 2.0 1 1 1 2 2 2 2 Tumour suppressor, Mitostatin DUF624 PF04854.9 ESL08062.1 - 0.05 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF624 RNA_pol_Rpb1_5 PF04998.12 ESL08063.1 - 9.6e-61 205.4 0.0 7.7e-60 202.4 0.0 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ESL08063.1 - 7.1e-47 159.4 0.0 7.1e-47 159.4 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 ESL08063.1 - 3.5e-32 111.3 0.0 6.6e-32 110.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESL08063.1 - 2.7e-15 56.0 0.0 2.7e-15 56.0 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 BACK PF07707.10 ESL08064.1 - 0.036 13.8 0.3 0.062 13.1 0.2 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch L27 PF02828.11 ESL08064.1 - 0.12 12.1 0.4 0.24 11.1 0.3 1.4 1 0 0 1 1 1 0 L27 domain Mito_carr PF00153.22 ESL08065.1 - 1.1e-53 178.9 4.6 3.2e-18 65.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.27 ESL08067.1 - 0.014 15.2 0.5 0.24 11.3 0.0 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat PLRV_ORF5 PF01690.12 ESL08067.1 - 2.7 7.0 17.6 4.6 6.2 12.2 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Sld5 PF05916.6 ESL08068.1 - 2e-08 34.4 0.1 3.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Peptidase_U49 PF10463.4 ESL08068.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase U49 Acetyltransf_1 PF00583.19 ESL08070.1 - 7e-13 48.4 0.1 1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 ESL08070.1 - 4.1e-09 36.0 0.1 8.2e-09 35.1 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 ESL08070.1 - 5.7e-06 26.3 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESL08070.1 - 0.00027 21.0 0.0 0.00047 20.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA PF00004.24 ESL08073.1 - 1.3e-32 112.7 0.0 8.3e-29 100.4 0.0 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL08073.1 - 1.1e-11 45.1 7.8 7.9e-05 22.7 0.1 5.1 3 2 2 5 5 5 2 AAA ATPase domain NACHT PF05729.7 ESL08073.1 - 6.1e-09 35.7 0.1 0.28 10.8 0.0 4.4 3 1 1 4 4 4 2 NACHT domain AAA_22 PF13401.1 ESL08073.1 - 4.5e-08 33.3 1.0 0.0029 17.7 0.0 4.1 3 2 0 3 3 3 2 AAA domain AAA_19 PF13245.1 ESL08073.1 - 4.6e-08 32.6 4.8 0.062 13.0 0.0 4.2 4 0 0 4 4 3 3 Part of AAA domain AAA_14 PF13173.1 ESL08073.1 - 1.8e-05 24.6 0.0 0.00043 20.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESL08073.1 - 2.6e-05 24.1 0.4 0.026 14.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESL08073.1 - 3.9e-05 23.3 0.1 0.011 15.4 0.0 3.8 3 2 0 3 3 2 1 AAA domain (dynein-related subfamily) T2SE PF00437.15 ESL08073.1 - 8e-05 21.6 0.0 0.047 12.5 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_17 PF13207.1 ESL08073.1 - 0.00043 21.0 0.3 0.27 12.0 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.1 ESL08073.1 - 0.00048 19.7 0.5 0.032 13.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 ESL08073.1 - 0.00073 19.2 0.0 2.2 7.8 0.0 3.7 2 1 2 4 4 4 1 Archaeal ATPase AAA_29 PF13555.1 ESL08073.1 - 0.0014 18.0 0.1 0.67 9.5 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Sigma54_activat PF00158.21 ESL08073.1 - 0.0017 17.8 0.0 0.21 11.0 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.16 ESL08073.1 - 0.0017 17.5 0.6 0.13 11.3 0.1 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 ESL08073.1 - 0.0026 17.2 0.0 0.43 9.9 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 ESL08073.1 - 0.0039 16.3 0.0 1.7 7.6 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.17 ESL08073.1 - 0.0058 15.5 0.0 1.5 7.6 0.0 2.9 2 1 1 3 3 3 1 NB-ARC domain AFG1_ATPase PF03969.11 ESL08073.1 - 0.0081 15.0 0.9 0.075 11.8 0.6 2.5 1 1 0 1 1 1 1 AFG1-like ATPase RNA_helicase PF00910.17 ESL08073.1 - 0.026 14.6 0.1 3 8.0 0.0 3.1 4 0 0 4 4 2 0 RNA helicase AAA_18 PF13238.1 ESL08073.1 - 0.036 14.3 0.3 1.9 8.8 0.0 2.8 3 0 0 3 3 3 0 AAA domain PhoH PF02562.11 ESL08073.1 - 0.054 12.7 0.1 3.8 6.6 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein DUF815 PF05673.8 ESL08073.1 - 0.06 12.2 0.1 5.7 5.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.13 ESL08073.1 - 0.061 12.7 0.0 3.4 7.0 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Gtr1_RagA PF04670.7 ESL08073.1 - 0.065 12.3 0.0 0.44 9.6 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Sigma54_activ_2 PF14532.1 ESL08073.1 - 0.067 13.2 0.0 3.1 7.8 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.1 ESL08073.1 - 0.076 12.5 0.1 5.3 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.9 ESL08073.1 - 0.086 12.7 0.0 5.4 6.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) DUF2075 PF09848.4 ESL08073.1 - 0.1 11.5 0.1 9 5.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UPF0079 PF02367.12 ESL08073.1 - 0.12 12.0 0.1 1.5 8.4 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 ESL08073.1 - 0.17 11.8 1.0 15 5.4 0.0 3.5 3 1 1 4 4 4 0 AAA domain DEAD PF00270.24 ESL08073.1 - 0.18 11.3 0.4 9.3 5.7 0.0 3.0 3 1 0 3 3 3 0 DEAD/DEAH box helicase KaiC PF06745.8 ESL08073.1 - 0.18 10.8 0.2 4.7 6.2 0.0 2.6 3 0 0 3 3 3 0 KaiC AAA_23 PF13476.1 ESL08073.1 - 0.2 11.9 1.8 24 5.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_10 PF12846.2 ESL08073.1 - 0.23 10.8 2.9 6 6.2 0.0 2.8 3 1 1 4 4 3 0 AAA-like domain EAP30 PF04157.11 ESL08074.1 - 2.3e-75 252.5 0.1 2.8e-75 252.2 0.1 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Aldedh PF00171.17 ESL08075.1 - 4.7e-19 68.0 3.8 1.4e-06 26.9 0.0 3.0 3 0 0 3 3 3 3 Aldehyde dehydrogenase family DNA_pol_E_B PF04042.11 ESL08076.1 - 1.1e-29 103.1 0.1 5.4e-29 100.9 0.1 1.9 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pkinase PF00069.20 ESL08077.1 - 8.3e-62 208.6 0.0 1e-61 208.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08077.1 - 2e-42 145.0 0.0 3e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08077.1 - 0.085 11.7 0.0 0.35 9.7 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.9 ESL08077.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESL08078.1 - 1.5e-54 184.8 0.0 1.8e-54 184.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08078.1 - 3.4e-37 127.9 0.0 4.2e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_3 PF08239.6 ESL08078.1 - 9.3e-06 25.7 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Kinase-like PF14531.1 ESL08078.1 - 1.5e-05 24.1 0.0 9.5e-05 21.4 0.0 2.1 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESL08078.1 - 0.045 13.4 0.0 1.9 8.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family SH3_5 PF08460.5 ESL08078.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain LRRNT_2 PF08263.7 ESL08079.1 - 0.11 12.4 1.3 0.24 11.4 0.9 1.5 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain DUF3446 PF11928.3 ESL08079.1 - 0.32 11.2 5.5 0.9 9.7 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) AAA PF00004.24 ESL08080.1 - 1.2e-12 48.2 0.0 3.2e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL08080.1 - 0.0012 19.7 0.0 0.016 15.9 0.0 2.9 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESL08080.1 - 0.0036 16.3 0.0 0.0072 15.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IQ PF00612.22 ESL08080.1 - 0.011 15.2 0.5 0.011 15.2 0.3 3.8 4 0 0 4 4 4 0 IQ calmodulin-binding motif Bac_DnaA PF00308.13 ESL08080.1 - 0.013 15.1 0.0 0.063 12.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_16 PF13191.1 ESL08080.1 - 0.017 15.1 0.0 0.017 15.1 0.0 3.0 2 2 1 3 3 3 0 AAA ATPase domain AAA_19 PF13245.1 ESL08080.1 - 0.02 14.6 0.3 0.17 11.6 0.0 2.8 3 0 0 3 3 3 0 Part of AAA domain cobW PF02492.14 ESL08080.1 - 0.034 13.5 0.0 0.08 12.3 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 ESL08080.1 - 0.039 13.3 0.3 0.22 10.9 0.0 2.4 2 1 1 3 3 3 0 AAA domain Viral_helicase1 PF01443.13 ESL08080.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 ESL08080.1 - 0.071 13.2 0.0 0.41 10.7 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 ESL08080.1 - 0.086 12.7 0.0 0.086 12.7 0.0 3.1 4 0 0 4 4 4 0 AAA domain AAA_16 PF13191.1 ESL08081.1 - 3e-07 30.5 0.2 3.2e-06 27.2 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain DUF2791 PF10923.3 ESL08081.1 - 0.05 12.1 0.0 0.083 11.4 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) NB-ARC PF00931.17 ESL08081.1 - 0.053 12.3 0.0 0.089 11.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.1 ESL08081.1 - 0.054 13.6 0.0 0.18 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 ESL08081.1 - 0.078 12.6 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Rep_fac-A_3 PF08661.6 ESL08081.1 - 0.084 12.7 0.0 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Replication factor A protein 3 Zeta_toxin PF06414.7 ESL08081.1 - 0.093 11.8 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin cobW PF02492.14 ESL08081.1 - 0.14 11.5 0.0 0.4 10.1 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_M22 PF00814.20 ESL08082.1 - 2.6e-63 214.0 0.0 3.4e-63 213.6 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family DUF2779 PF11074.3 ESL08084.1 - 1e-18 67.6 0.0 1.5e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function(DUF2779) Tropomyosin_1 PF12718.2 ESL08085.1 - 0.00026 20.8 1.2 0.00026 20.8 0.8 8.0 4 3 3 7 7 7 3 Tropomyosin like NPV_P10 PF05531.7 ESL08085.1 - 0.016 15.4 0.2 0.016 15.4 0.1 8.4 8 1 1 9 9 9 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 ESL08085.1 - 0.45 9.6 26.6 2.6 7.1 0.3 5.6 3 2 3 6 6 6 0 Reovirus sigma C capsid protein WD40 PF00400.27 ESL08086.1 - 5.9e-17 60.8 8.8 6e-09 35.4 0.2 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat CPSF_A PF03178.10 ESL08086.1 - 0.009 15.1 0.0 0.18 10.8 0.0 2.4 2 0 0 2 2 2 1 CPSF A subunit region DUF3312 PF11768.3 ESL08086.1 - 0.044 12.0 0.1 7.1 4.7 0.0 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF3312) HEAT_2 PF13646.1 ESL08087.1 - 6.5e-08 32.7 3.5 0.037 14.3 0.0 5.8 4 1 2 6 6 6 4 HEAT repeats HEAT PF02985.17 ESL08087.1 - 1.4e-06 27.8 18.2 1.5 9.1 0.1 10.0 10 0 0 10 10 10 2 HEAT repeat Arm PF00514.18 ESL08087.1 - 0.13 12.1 4.2 82 3.2 0.0 5.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Rtt106 PF08512.7 ESL08088.1 - 7.7e-14 51.4 0.0 7e-12 45.1 0.0 2.3 2 0 0 2 2 2 1 Histone chaperone Rttp106-like CDC45 PF02724.9 ESL08088.1 - 0.018 13.0 31.5 0.027 12.5 21.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Iso_dh PF00180.15 ESL08088.1 - 0.021 13.7 0.0 0.034 13.0 0.0 1.2 1 0 0 1 1 1 0 Isocitrate/isopropylmalate dehydrogenase Nop14 PF04147.7 ESL08088.1 - 0.034 12.0 36.9 0.05 11.5 25.6 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 ESL08088.1 - 0.69 9.1 39.8 1.1 8.5 27.6 1.3 1 0 0 1 1 1 0 SDA1 Daxx PF03344.10 ESL08088.1 - 2.5 6.5 35.9 3.6 5.9 24.9 1.2 1 0 0 1 1 1 0 Daxx Family Trypan_PARP PF05887.6 ESL08088.1 - 2.7 7.8 16.5 1.8 8.3 9.7 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) YL1 PF05764.8 ESL08088.1 - 5.3 6.5 36.6 8.5 5.9 25.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Paf1 PF03985.8 ESL08088.1 - 5.5 5.6 28.6 8.4 5.0 19.8 1.2 1 0 0 1 1 1 0 Paf1 Pkinase PF00069.20 ESL08089.1 - 4.2e-62 209.6 0.0 5.3e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08089.1 - 1.6e-40 138.8 0.0 2.3e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL08089.1 - 2.4e-05 24.1 0.0 0.0014 18.3 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL08089.1 - 6.3e-05 22.0 0.0 0.00078 18.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RRM_1 PF00076.17 ESL08090.1 - 0.052 13.1 0.1 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_12 PF13424.1 ESL08091.1 - 3.5e-13 49.2 12.7 4.1e-06 26.6 0.9 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08091.1 - 4e-06 26.3 9.1 0.81 9.7 0.2 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESL08091.1 - 6.8e-06 25.6 6.3 0.18 11.4 0.1 3.5 3 0 0 3 3 3 2 TPR repeat SNAP PF14938.1 ESL08091.1 - 3.5e-05 23.0 9.6 0.003 16.7 3.8 2.4 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_14 PF13428.1 ESL08091.1 - 9.6e-05 22.6 18.6 1.7 9.4 0.7 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08091.1 - 0.00011 21.6 4.1 3 7.8 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL08091.1 - 0.00033 21.2 2.2 0.00033 21.2 1.6 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08091.1 - 0.00055 19.4 9.4 1.5 8.5 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat Apc5 PF12862.2 ESL08091.1 - 0.0045 16.7 2.4 0.02 14.7 1.5 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 5 TPR_7 PF13176.1 ESL08091.1 - 0.0089 15.7 10.9 0.84 9.5 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL08091.1 - 0.015 15.1 2.2 0.069 13.0 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL08091.1 - 0.028 14.3 10.6 3.5 7.6 0.1 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESL08091.1 - 0.18 12.0 1.4 67 4.0 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ChaB PF06150.7 ESL08091.1 - 0.27 11.0 6.9 8 6.3 0.0 4.0 3 1 1 4 4 4 0 ChaB TPR_15 PF13429.1 ESL08091.1 - 0.51 9.3 15.5 0.25 10.3 8.1 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08091.1 - 3.9 8.1 15.6 9.8 6.8 0.1 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF349 PF03993.7 ESL08091.1 - 4.1 7.6 6.8 0.33 11.1 0.2 2.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) CENP-F_leu_zip PF10473.4 ESL08092.1 - 0.00049 19.9 19.4 0.00049 19.9 13.5 8.1 3 3 6 9 9 9 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3539 PF12058.3 ESL08092.1 - 0.053 13.3 7.2 0.94 9.3 0.9 3.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3539) Acid_PPase PF12689.2 ESL08092.1 - 0.33 10.5 3.4 0.39 10.3 0.0 2.6 3 0 0 3 3 3 0 Acid Phosphatase RRM_1 PF00076.17 ESL08093.1 - 5.3e-05 22.7 0.0 0.00012 21.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08093.1 - 0.022 14.5 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DOR PF14839.1 ESL08093.1 - 0.067 12.9 2.1 0.11 12.2 1.5 1.3 1 0 0 1 1 1 0 DOR family KduI PF04962.7 ESL08094.1 - 0.098 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 KduI/IolB family CENP-F_leu_zip PF10473.4 ESL08095.1 - 0.002 17.9 10.9 0.002 17.9 7.6 3.0 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 ESL08095.1 - 0.0034 17.0 22.4 0.0044 16.6 9.1 2.2 2 0 0 2 2 2 1 IncA protein CCDC-167 PF15188.1 ESL08095.1 - 0.024 14.5 8.4 0.024 14.5 5.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Tropomyosin_1 PF12718.2 ESL08095.1 - 0.05 13.4 22.7 0.44 10.3 8.6 2.6 2 1 0 2 2 2 0 Tropomyosin like DUF4472 PF14739.1 ESL08095.1 - 0.075 13.4 13.6 0.038 14.4 5.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) NPV_P10 PF05531.7 ESL08095.1 - 0.21 11.8 1.2 90 3.4 0.1 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMCO5 PF14992.1 ESL08095.1 - 0.25 10.4 14.9 0.068 12.3 5.8 2.1 2 0 0 2 2 2 0 TMCO5 family Mod_r PF07200.8 ESL08095.1 - 0.41 10.5 19.7 0.98 9.3 1.9 3.0 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Filament PF00038.16 ESL08095.1 - 0.42 10.0 25.4 0.14 11.6 0.6 3.0 1 1 1 3 3 3 0 Intermediate filament protein IKKbetaNEMObind PF12179.3 ESL08095.1 - 0.53 10.1 2.5 0.68 9.8 0.5 2.1 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Occludin_ELL PF07303.8 ESL08095.1 - 0.54 11.0 13.0 28 5.5 3.6 3.4 2 1 1 3 3 3 0 Occludin homology domain DUF342 PF03961.8 ESL08095.1 - 0.59 8.4 10.6 0.2 10.0 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DivIC PF04977.10 ESL08095.1 - 0.67 9.4 15.7 1.2 8.6 0.5 3.4 3 0 0 3 3 3 0 Septum formation initiator DUF2570 PF10828.3 ESL08095.1 - 1 8.9 9.2 5.6 6.6 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) DUF2730 PF10805.3 ESL08095.1 - 1.1 9.0 8.1 1.2 8.9 2.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) PolyA_pol PF01743.15 ESL08095.1 - 1.2 9.3 3.9 2.1 8.5 0.4 2.7 1 1 1 2 2 2 0 Poly A polymerase head domain SlyX PF04102.7 ESL08095.1 - 1.2 9.5 11.0 2.1 8.7 0.5 3.6 3 0 0 3 3 3 0 SlyX Jnk-SapK_ap_N PF09744.4 ESL08095.1 - 1.3 8.9 15.0 0.65 9.9 5.7 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF16 PF01519.11 ESL08095.1 - 1.5 9.1 7.4 7.3 6.8 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4200 PF13863.1 ESL08095.1 - 2.1 8.2 22.7 0.05 13.5 7.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Syntaxin-6_N PF09177.6 ESL08095.1 - 3.2 8.2 12.7 1.5 9.2 2.5 3.4 2 2 1 3 3 3 0 Syntaxin 6, N-terminal BLOC1_2 PF10046.4 ESL08095.1 - 3.5 7.8 11.1 3.6 7.7 0.6 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlxA PF14282.1 ESL08095.1 - 6.2 6.8 11.9 2.7 7.9 3.0 3.0 2 1 0 2 2 2 0 FlxA-like protein DUF972 PF06156.8 ESL08095.1 - 8.5 6.7 16.0 7.1 7.0 0.7 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Herpes_UL6 PF01763.11 ESL08095.1 - 9.9 4.2 16.0 1.7 6.7 5.9 2.6 2 1 0 2 2 2 0 Herpesvirus UL6 like SSB PF00436.20 ESL08096.1 - 4.7e-06 26.3 0.0 6.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family tRNA_anti-codon PF01336.20 ESL08096.1 - 0.0078 16.0 0.1 0.023 14.5 0.0 1.8 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain Rad1 PF02144.11 ESL08098.1 - 1.9e-08 33.4 0.0 8.3e-08 31.3 0.0 1.7 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 DUF4109 PF13397.1 ESL08099.1 - 0.046 14.1 0.0 0.06 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4109) Steroid_dh PF02544.11 ESL08100.1 - 8.5e-24 84.0 0.3 1.4e-23 83.3 0.2 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 ESL08100.1 - 0.00046 19.5 0.4 0.00069 18.9 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Bax1-I PF01027.15 ESL08100.1 - 2.6 7.5 8.0 4.1 6.9 1.9 2.9 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 PAS_4 PF08448.5 ESL08101.1 - 0.14 12.1 4.1 0.78 9.7 0.1 3.3 3 0 0 3 3 3 0 PAS fold G10 PF01125.12 ESL08102.1 - 1e-54 184.0 1.8 1.4e-54 183.6 1.2 1.2 1 0 0 1 1 1 1 G10 protein Ras PF00071.17 ESL08103.1 - 2.7e-40 137.3 0.0 3.2e-40 137.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL08103.1 - 1.1e-15 58.1 0.0 1.6e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL08103.1 - 1.4e-14 53.7 0.0 1.8e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL08103.1 - 4e-06 26.3 0.0 0.00019 20.8 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL08103.1 - 3e-05 23.3 0.0 3.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESL08103.1 - 0.00019 20.6 0.0 0.00032 19.9 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL08103.1 - 0.0016 18.4 0.0 0.0022 17.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 ESL08103.1 - 0.019 15.1 0.0 0.043 14.0 0.0 1.6 2 0 0 2 2 2 0 RNA helicase PRK PF00485.13 ESL08103.1 - 0.033 13.7 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 ESL08103.1 - 0.047 12.7 0.0 0.22 10.5 0.0 1.9 1 1 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 ESL08103.1 - 0.072 13.0 0.0 3.5 7.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.1 ESL08103.1 - 0.079 13.1 0.0 0.18 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain Med25_VWA PF11265.3 ESL08105.1 - 0.012 14.6 0.0 0.021 13.8 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A Lebercilin PF15619.1 ESL08105.1 - 0.019 14.3 1.9 0.019 14.3 1.3 3.5 4 0 0 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF2365 PF10157.4 ESL08105.1 - 0.044 13.6 0.7 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2365) Vac_Fusion PF02346.11 ESL08105.1 - 0.16 11.4 2.1 0.62 9.5 1.4 2.0 1 0 0 1 1 1 0 Chordopoxvirus fusion protein DUF904 PF06005.7 ESL08105.1 - 0.52 10.6 7.7 8.1 6.8 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF904) GAS PF13851.1 ESL08105.1 - 3.3 6.8 18.9 3.5 6.7 0.4 3.5 2 2 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1515 PF07439.6 ESL08105.1 - 5.9 6.7 7.6 0.95 9.2 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) cobW PF02492.14 ESL08106.1 - 1.5e-43 148.3 0.0 1.8e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 ESL08106.1 - 1.9e-05 24.2 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_19 PF13245.1 ESL08106.1 - 0.0021 17.7 0.2 0.0072 16.0 0.1 2.0 2 1 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 ESL08106.1 - 0.0084 15.9 0.1 0.018 14.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESL08106.1 - 0.031 13.8 0.0 0.072 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 ESL08106.1 - 0.066 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 ESL08106.1 - 0.067 12.7 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein CbiA PF01656.18 ESL08106.1 - 0.068 12.5 0.0 0.21 10.9 0.0 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.1 ESL08106.1 - 0.071 13.4 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESL08106.1 - 0.075 12.7 0.0 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Mito_carr PF00153.22 ESL08108.1 - 7.3e-31 105.7 3.3 1.8e-11 43.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein POTRA_2 PF08479.6 ESL08108.1 - 0.11 12.2 0.2 5.3 6.7 0.0 2.4 2 0 0 2 2 2 0 POTRA domain, ShlB-type WD40 PF00400.27 ESL08109.1 - 1.4e-12 46.9 9.6 6.8e-05 22.5 0.1 5.7 5 1 0 5 5 5 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESL08109.1 - 0.013 14.2 0.0 4.1 6.0 0.0 2.3 1 1 0 2 2 2 0 Nup133 N terminal like APG6 PF04111.7 ESL08109.1 - 2.6 6.9 8.8 5.2 6.0 6.1 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Patatin PF01734.17 ESL08110.1 - 9.3e-08 32.2 0.5 2.2e-06 27.7 0.4 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase TPR_11 PF13414.1 ESL08111.1 - 3.9e-05 23.2 3.5 3.9e-05 23.1 0.5 2.5 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.1 ESL08111.1 - 0.00052 19.9 1.4 0.00052 19.9 1.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat IQ PF00612.22 ESL08111.1 - 0.024 14.2 3.2 0.028 14.0 0.2 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif TPR_1 PF00515.23 ESL08111.1 - 0.031 13.8 0.5 3.4 7.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08111.1 - 0.058 13.3 7.1 2 8.5 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank PF00023.25 ESL08112.1 - 7.2e-13 47.6 0.6 2e-05 24.1 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 ESL08112.1 - 2.5e-12 46.9 0.1 1.4e-05 25.2 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL08112.1 - 2.5e-12 46.9 0.0 0.0096 16.4 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL08112.1 - 1.8e-09 37.5 0.0 1.9e-05 24.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL08112.1 - 3.1e-09 36.1 0.1 0.0072 16.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat TB2_DP1_HVA22 PF03134.14 ESL08112.1 - 0.078 12.7 0.2 0.23 11.2 0.1 1.8 2 0 0 2 2 2 0 TB2/DP1, HVA22 family Anticodon_1 PF08264.8 ESL08113.1 - 7e-37 126.5 0.0 1.4e-36 125.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1 PF00133.17 ESL08113.1 - 3.2e-19 68.4 0.0 4.7e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Val_tRNA-synt_C PF10458.4 ESL08113.1 - 2.6e-12 46.6 4.7 4.6e-12 45.8 3.2 1.4 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm DUF342 PF03961.8 ESL08113.1 - 0.023 13.1 0.1 0.03 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) tRNA-synt_1g PF09334.6 ESL08113.1 - 0.029 13.0 0.0 0.082 11.5 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (M) IncA PF04156.9 ESL08113.1 - 0.045 13.3 1.4 0.075 12.6 1.0 1.2 1 0 0 1 1 1 0 IncA protein tRNA-synt_1f PF01921.13 ESL08113.1 - 0.071 11.7 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) TRAM_LAG1_CLN8 PF03798.11 ESL08113.1 - 0.094 12.2 0.3 0.19 11.2 0.0 1.6 2 0 0 2 2 2 0 TLC domain Mnd1 PF03962.10 ESL08113.1 - 0.11 12.1 1.4 0.2 11.3 1.0 1.4 1 0 0 1 1 1 0 Mnd1 family SlyX PF04102.7 ESL08113.1 - 0.21 11.9 6.7 0.81 10.1 0.1 3.4 3 0 0 3 3 3 0 SlyX DivIC PF04977.10 ESL08113.1 - 0.82 9.2 4.7 0.14 11.6 0.2 1.9 2 0 0 2 2 2 0 Septum formation initiator Prefoldin_2 PF01920.15 ESL08113.1 - 1.3 8.8 7.4 0.21 11.3 0.8 2.3 2 0 0 2 2 2 0 Prefoldin subunit LSM PF01423.17 ESL08114.1 - 1.3e-13 50.2 0.1 1.7e-13 49.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Aa_trans PF01490.13 ESL08115.1 - 3e-42 144.5 28.6 3.5e-42 144.3 19.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2518 PF10726.4 ESL08116.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of function (DUF2518) zf-C3HC PF07967.8 ESL08116.1 - 0.22 11.2 1.8 7.6 6.3 0.0 2.9 3 0 0 3 3 3 0 C3HC zinc finger-like Aa_trans PF01490.13 ESL08117.1 - 1e-43 149.3 34.6 1.2e-43 149.1 24.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL08117.1 - 1.7e-05 23.8 6.3 1.7e-05 23.8 4.4 2.3 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family PI3_PI4_kinase PF00454.22 ESL08119.1 - 2.2e-44 151.6 0.0 1.3e-41 142.6 0.0 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 ESL08119.1 - 2.9e-33 114.6 0.6 5.1e-33 113.8 0.4 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.19 ESL08119.1 - 4.1e-13 49.3 0.0 7.3e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Glyco_trans_1_4 PF13692.1 ESL08120.1 - 4.4e-13 49.5 0.0 1.1e-12 48.2 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESL08120.1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 ESL08120.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 RNA_POL_M_15KD PF02150.11 ESL08121.1 - 8.7e-05 22.1 3.2 8.7e-05 22.1 2.2 2.5 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 ESL08121.1 - 0.00091 18.8 3.0 0.00091 18.8 2.0 3.0 3 1 0 3 3 3 1 Transcription factor S-II (TFIIS) zf-Sec23_Sec24 PF04810.10 ESL08121.1 - 0.03 13.8 2.0 0.03 13.8 1.4 3.0 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Rep_fac-A_C PF08646.5 ESL08121.1 - 0.039 13.6 4.7 0.3 10.8 0.1 2.5 2 1 1 3 3 3 0 Replication factor-A C terminal domain Tmemb_55A PF09788.4 ESL08121.1 - 0.16 11.0 1.0 3.2 6.8 0.0 2.1 2 0 0 2 2 2 0 Transmembrane protein 55A RRN7 PF11781.3 ESL08121.1 - 0.46 10.0 4.1 20 4.7 0.0 3.3 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 zinc_ribbon_2 PF13240.1 ESL08121.1 - 0.5 9.9 5.3 1.7 8.2 0.0 2.9 3 1 0 3 3 3 0 zinc-ribbon domain HypA PF01155.14 ESL08121.1 - 0.7 9.5 4.5 2.9 7.5 0.1 2.3 1 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family PyrI_C PF02748.10 ESL08121.1 - 1.3 8.5 5.7 5.9 6.3 0.1 3.1 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn-ribbon_8 PF09723.5 ESL08121.1 - 1.6 8.7 9.0 3.5 7.6 0.4 3.6 4 0 0 4 4 4 0 Zinc ribbon domain zf-3CxxC PF13695.1 ESL08121.1 - 1.8 8.8 10.3 4.2 7.6 0.1 3.0 2 1 0 2 2 2 0 Zinc-binding domain Zn_Tnp_IS1595 PF12760.2 ESL08121.1 - 2.8 7.8 9.8 4 7.3 0.2 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Zn_ribbon_recom PF13408.1 ESL08121.1 - 6.5 7.0 6.6 1.3 9.3 0.1 2.3 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain tRNA_anti-codon PF01336.20 ESL08122.1 - 0.00054 19.7 0.1 0.00086 19.1 0.1 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SSB PF00436.20 ESL08122.1 - 0.0067 16.2 0.1 0.04 13.7 0.1 2.0 1 1 0 1 1 1 1 Single-strand binding protein family Ten1_2 PF15490.1 ESL08122.1 - 0.089 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit zf-MYND PF01753.13 ESL08123.1 - 1.4e-10 40.8 8.8 1.4e-10 40.8 6.1 1.8 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.1 ESL08123.1 - 0.012 15.4 2.2 0.032 14.0 1.5 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 LRR_4 PF12799.2 ESL08124.1 - 7.5e-22 76.5 25.3 0.00014 21.3 0.2 6.5 2 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL08124.1 - 2.8e-15 55.8 23.0 0.00013 21.6 0.9 5.6 2 2 4 6 6 6 6 Leucine rich repeat LRR_9 PF14580.1 ESL08124.1 - 9.1e-07 28.5 0.9 8.7e-06 25.4 0.0 2.7 1 1 0 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.1 ESL08124.1 - 0.00018 21.2 18.1 10 6.5 0.0 8.9 9 1 1 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.28 ESL08124.1 - 0.013 15.4 38.8 14 6.1 0.1 11.0 11 1 1 12 12 12 0 Leucine Rich Repeat Peptidase_M8 PF01457.11 ESL08125.1 - 6.1e-25 87.5 0.0 7e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin DUF3617 PF12276.3 ESL08125.1 - 0.36 10.2 3.8 2.9 7.3 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3617) TFIIF_alpha PF05793.7 ESL08126.1 - 0.34 9.2 1.2 0.42 8.9 0.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Metallophos PF00149.23 ESL08127.1 - 2.8e-16 59.5 0.1 3.5e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4455 PF14643.1 ESL08128.1 - 0.0014 17.3 7.8 0.0017 17.0 5.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) DUF2982 PF11201.3 ESL08128.1 - 0.063 12.6 0.1 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2982) V_ATPase_I PF01496.14 ESL08128.1 - 0.066 11.0 2.3 0.064 11.1 1.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4054 PF13262.1 ESL08128.1 - 0.13 12.4 0.1 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) Flg_bb_rod PF00460.15 ESL08128.1 - 0.16 11.7 0.3 0.31 10.8 0.2 1.5 1 0 0 1 1 1 0 Flagella basal body rod protein GBP_C PF02841.9 ESL08128.1 - 0.16 11.0 9.2 0.49 9.5 5.9 1.8 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Baculo_PEP_C PF04513.7 ESL08128.1 - 0.17 11.7 2.5 1.6 8.5 0.1 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 ESL08128.1 - 0.17 11.9 2.9 0.51 10.4 2.0 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4071 PF13281.1 ESL08128.1 - 0.2 10.4 3.4 0.25 10.1 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) SlyX PF04102.7 ESL08128.1 - 0.28 11.6 8.9 2.2 8.7 1.9 3.1 2 1 1 3 3 3 0 SlyX ADIP PF11559.3 ESL08128.1 - 0.37 10.6 11.8 0.55 10.1 4.4 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF2984 PF11203.3 ESL08128.1 - 0.58 10.2 2.8 3.5 7.7 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2984) MCRS_N PF13325.1 ESL08128.1 - 0.7 9.3 8.8 0.44 10.0 4.8 1.5 1 1 1 2 2 2 0 N-terminal region of micro-spherule protein DUF3450 PF11932.3 ESL08128.1 - 0.72 9.0 6.4 0.33 10.1 2.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) zf-ZPR1 PF03367.8 ESL08128.1 - 0.79 8.8 6.2 2.7 7.1 1.2 2.4 1 1 2 3 3 3 0 ZPR1 zinc-finger domain Med9 PF07544.8 ESL08128.1 - 1.3 8.8 10.0 1.3 8.8 5.6 2.2 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Fez1 PF06818.10 ESL08128.1 - 1.5 8.8 12.1 0.69 9.9 6.3 1.7 1 1 0 1 1 1 0 Fez1 Tup_N PF08581.5 ESL08128.1 - 1.6 9.0 8.5 29 4.9 5.0 2.6 2 1 1 3 3 3 0 Tup N-terminal Med21 PF11221.3 ESL08128.1 - 2.9 7.8 12.1 0.5 10.3 5.0 2.1 2 1 1 3 3 3 0 Subunit 21 of Mediator complex TMF_DNA_bd PF12329.3 ESL08128.1 - 3.7 7.4 13.2 2 8.2 2.9 3.4 2 2 2 4 4 4 0 TATA element modulatory factor 1 DNA binding ENT PF03735.9 ESL08128.1 - 4.5 7.0 7.5 1.3 8.8 1.7 2.4 2 1 1 3 3 3 0 ENT domain Cortex-I_coil PF09304.5 ESL08128.1 - 4.9 7.2 12.8 28 4.8 5.7 2.5 1 1 0 2 2 2 0 Cortexillin I, coiled coil XhlA PF10779.4 ESL08128.1 - 8.9 6.3 8.3 34 4.4 0.1 2.4 2 1 0 2 2 2 0 Haemolysin XhlA PPR_2 PF13041.1 ESL08129.1 - 1.2e-41 140.4 5.4 3.8e-16 58.7 0.2 5.6 2 1 4 6 6 6 5 PPR repeat family PPR_3 PF13812.1 ESL08129.1 - 1.4e-36 121.6 7.5 1.3e-09 37.5 0.0 6.4 6 0 0 6 6 6 6 Pentatricopeptide repeat domain PPR PF01535.15 ESL08129.1 - 2.1e-30 102.5 0.8 5.3e-08 32.3 0.0 6.9 7 0 0 7 7 7 4 PPR repeat PPR_1 PF12854.2 ESL08129.1 - 5.7e-26 89.6 0.3 4.8e-05 22.7 0.0 5.4 5 0 0 5 5 5 5 PPR repeat TPR_14 PF13428.1 ESL08129.1 - 7.5e-07 29.2 3.2 0.46 11.2 0.0 5.7 4 2 2 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08129.1 - 4.1e-06 26.1 0.0 0.13 12.1 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.12 ESL08129.1 - 0.0013 19.0 7.1 5 7.4 0.1 4.2 2 2 2 4 4 4 2 Bacterial transcriptional activator domain Clathrin PF00637.15 ESL08129.1 - 0.0017 17.9 0.0 0.085 12.4 0.0 3.0 1 1 0 1 1 1 1 Region in Clathrin and VPS Apc3 PF12895.2 ESL08129.1 - 0.0024 17.9 0.0 1.2 9.2 0.0 3.0 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESL08129.1 - 0.0032 17.7 0.0 1.2 9.5 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08129.1 - 0.015 15.2 0.0 4.2 7.3 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.1 ESL08129.1 - 0.023 13.7 0.2 0.86 8.6 0.0 2.7 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08129.1 - 0.025 15.0 0.0 38 5.0 0.0 3.9 4 1 0 4 4 3 0 Tetratricopeptide repeat Ank_5 PF13857.1 ESL08129.1 - 0.048 13.9 0.7 2.8 8.3 0.0 2.9 2 1 1 3 3 3 0 Ankyrin repeats (many copies) DHquinase_II PF01220.14 ESL08130.1 - 0.38 10.0 1.9 0.57 9.5 0.4 1.8 1 1 1 2 2 2 0 Dehydroquinase class II Ran_BP1 PF00638.13 ESL08131.1 - 1.1e-05 25.4 0.1 8.1e-05 22.6 0.1 2.4 2 1 0 2 2 2 1 RanBP1 domain NUP50 PF08911.6 ESL08131.1 - 0.0016 18.7 0.2 0.0016 18.7 0.2 2.6 2 1 0 2 2 2 1 NUP50 (Nucleoporin 50 kDa) DUF221 PF02714.10 ESL08133.1 - 1.7e-37 129.0 4.7 3.5e-37 127.9 3.3 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF221 SlyX PF04102.7 ESL08133.1 - 0.035 14.4 0.5 0.086 13.2 0.4 1.6 1 0 0 1 1 1 0 SlyX M_domain PF12938.2 ESL08133.1 - 1.5 8.5 4.6 11 5.7 0.0 2.2 2 0 0 2 2 2 0 M domain of GW182 Epimerase PF01370.16 ESL08135.1 - 6.3e-08 32.3 0.0 1.3e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL08135.1 - 1.4e-05 24.1 0.0 2.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain Nop53 PF07767.6 ESL08136.1 - 2.9e-15 56.1 15.7 5.5e-15 55.2 10.9 1.4 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF4557 PF15101.1 ESL08136.1 - 0.22 11.3 6.1 0.23 11.2 3.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4557) Kinesin PF00225.18 ESL08137.1 - 5.4e-91 304.7 0.0 1e-90 303.8 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain SAM_1 PF00536.25 ESL08137.1 - 2.1e-05 24.6 1.6 3e-05 24.1 0.2 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESL08137.1 - 0.00025 20.8 0.2 0.0006 19.6 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RE_SacI PF09566.5 ESL08138.1 - 0.0081 15.1 0.2 0.013 14.4 0.1 1.2 1 0 0 1 1 1 1 SacI restriction endonuclease FAST_1 PF06743.10 ESL08138.1 - 0.046 13.4 0.4 15 5.4 0.1 3.0 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 WASH_WAHD PF11945.3 ESL08139.1 - 2e-32 112.6 0.0 3.6e-18 65.9 0.0 2.1 2 0 0 2 2 2 2 WAHD domain of WASH complex Synaptobrevin PF00957.16 ESL08140.1 - 0.28 10.8 6.8 0.055 13.0 1.6 2.2 2 0 0 2 2 2 0 Synaptobrevin DivIC PF04977.10 ESL08140.1 - 9.9 5.7 20.3 0.034 13.6 1.0 3.5 3 1 0 3 3 3 0 Septum formation initiator LRR_6 PF13516.1 ESL08141.1 - 4.4e-16 57.1 0.2 0.0054 16.6 0.1 5.8 6 0 0 6 6 6 4 Leucine Rich repeat DDDD PF10161.4 ESL08141.1 - 0.056 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative mitochondrial precursor protein SSXT PF05030.7 ESL08141.1 - 0.06 12.9 0.0 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 SSXT protein (N-terminal region) LRR_4 PF12799.2 ESL08141.1 - 0.065 12.8 0.0 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) CS PF04969.11 ESL08142.1 - 2.7e-07 31.0 1.4 4.7e-07 30.2 1.0 1.4 1 0 0 1 1 1 1 CS domain SpoIIE PF07228.7 ESL08143.1 - 0.00011 21.9 0.0 0.0022 17.7 0.0 2.3 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESL08143.1 - 0.00053 19.4 0.0 0.00081 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Pilt PF15453.1 ESL08144.1 - 1 8.9 7.9 1.5 8.4 5.5 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions V_ATPase_I PF01496.14 ESL08144.1 - 4 5.1 7.5 5.5 4.7 5.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIS_M PF07500.9 ESL08145.1 - 1.4e-06 28.3 0.0 2.5e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain DnaG_DnaB_bind PF08278.6 ESL08145.1 - 0.0064 16.7 0.5 0.012 15.8 0.4 1.4 1 1 0 1 1 1 1 DNA primase DnaG DnaB-binding TFIIS_C PF01096.13 ESL08145.1 - 1.2 8.8 8.9 1.7 8.3 4.5 2.4 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) DSPn PF14671.1 ESL08146.1 - 2.7e-26 92.2 0.0 3.4e-16 59.5 0.0 3.3 3 0 0 3 3 3 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 ESL08146.1 - 2.6e-11 43.2 0.1 1.4e-10 40.8 0.1 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESL08146.1 - 0.00039 20.4 0.0 0.00093 19.2 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 ESL08146.1 - 0.00045 19.6 0.1 0.00073 18.9 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ESL08146.1 - 0.028 14.6 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family IU_nuc_hydro PF01156.14 ESL08147.1 - 2e-14 53.5 0.0 6.7e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Alg14 PF08660.6 ESL08148.1 - 6.2e-52 176.0 0.0 9.7e-52 175.3 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_tran_28_C PF04101.11 ESL08148.1 - 3.2e-24 85.4 0.0 4.6e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESL08148.1 - 1.3e-07 31.1 0.0 2.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 1 CAF1 PF04857.15 ESL08149.1 - 1e-47 162.6 0.0 1.4e-47 162.2 0.0 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Histone PF00125.19 ESL08150.1 - 1.7e-23 82.5 1.5 1.9e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL08150.1 - 7.1e-06 25.9 0.7 9.9e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESL08150.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated CENP-S PF15630.1 ESL08150.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore component CENP-S YihI PF04220.7 ESL08150.1 - 0.52 9.6 2.3 0.69 9.2 1.6 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) APG6 PF04111.7 ESL08151.1 - 2.5e-26 92.4 4.5 1.5e-18 66.9 0.0 3.4 4 0 0 4 4 4 2 Autophagy protein Apg6 DUF1469 PF07332.6 ESL08152.1 - 0.033 13.9 0.6 0.033 13.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF3852 PF12963.2 ESL08152.1 - 0.049 13.6 3.4 0.098 12.7 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) Guanylate_kin PF00625.16 ESL08153.1 - 1.9e-47 161.1 0.0 2.2e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.1 ESL08153.1 - 1.4e-06 28.6 0.4 4.1e-06 27.1 0.3 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL08153.1 - 0.00041 20.2 0.0 0.00072 19.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL08153.1 - 0.0084 16.9 0.9 0.035 14.9 0.6 2.0 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESL08153.1 - 0.037 13.2 0.0 0.071 12.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESL08153.1 - 0.071 13.4 0.8 1.6 9.0 0.6 2.3 1 1 0 1 1 1 0 ABC transporter Pkinase PF00069.20 ESL08154.1 - 2.8e-07 29.9 2.4 0.0048 16.0 0.0 3.3 3 2 1 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08154.1 - 3.9e-05 22.8 0.0 0.00053 19.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Imm19 PF15567.1 ESL08154.1 - 0.066 13.2 0.0 0.21 11.5 0.0 1.9 1 0 0 1 1 1 0 Immunity protein 19 DUF342 PF03961.8 ESL08154.1 - 0.14 10.5 1.9 0.23 9.8 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) UPF0172 PF03665.8 ESL08154.1 - 0.83 9.0 5.0 1.6 8.1 3.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Exo70 PF03081.10 ESL08155.1 - 0.0087 14.8 0.0 0.015 14.1 0.0 1.4 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Pex14_N PF04695.8 ESL08156.1 - 3.6e-27 95.0 3.8 1.8e-26 92.8 0.0 3.0 3 0 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region ERM PF00769.14 ESL08156.1 - 0.00095 18.7 1.0 0.0017 17.9 0.7 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Rootletin PF15035.1 ESL08156.1 - 0.0062 16.5 1.8 0.0092 15.9 1.3 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Macoilin PF09726.4 ESL08156.1 - 0.018 13.3 0.6 0.021 13.1 0.4 1.1 1 0 0 1 1 1 0 Transmembrane protein TPR_MLP1_2 PF07926.7 ESL08156.1 - 0.021 14.5 6.4 0.034 13.8 4.4 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IR1-M PF12185.3 ESL08156.1 - 0.026 14.2 1.7 0.98 9.1 0.3 2.5 1 1 1 2 2 2 0 Nup358/RanBP2 E3 ligase domain DUF3450 PF11932.3 ESL08156.1 - 0.033 13.4 0.9 0.052 12.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Cortex-I_coil PF09304.5 ESL08156.1 - 0.041 13.9 7.5 0.08 12.9 5.2 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil DUF1465 PF07323.7 ESL08156.1 - 0.082 12.4 1.4 0.16 11.5 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) IF3_C PF00707.17 ESL08156.1 - 0.11 12.2 1.3 10 5.9 0.0 2.6 2 1 1 3 3 3 0 Translation initiation factor IF-3, C-terminal domain UBA_2 PF08587.6 ESL08156.1 - 0.14 12.3 0.1 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) DUF2051 PF09738.4 ESL08156.1 - 0.16 11.2 6.8 0.2 10.9 4.0 1.6 1 1 0 1 1 1 0 Double stranded RNA binding protein (DUF2051) DUF3584 PF12128.3 ESL08156.1 - 0.23 8.7 7.7 0.31 8.3 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DivIVA PF05103.8 ESL08156.1 - 0.26 11.3 4.5 0.49 10.4 0.3 2.3 2 0 0 2 2 2 0 DivIVA protein DUF972 PF06156.8 ESL08156.1 - 0.4 11.0 6.8 0.97 9.8 4.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Mnd1 PF03962.10 ESL08156.1 - 0.64 9.6 6.1 1.1 8.9 4.2 1.3 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.7 ESL08156.1 - 0.69 8.9 6.2 1.1 8.2 4.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-C4H2 PF10146.4 ESL08156.1 - 1.2 9.1 9.2 0.049 13.6 1.6 2.1 2 1 1 3 3 3 0 Zinc finger-containing protein PTH2 PF01981.11 ESL08157.1 - 5e-17 61.6 0.1 1.3e-16 60.3 0.0 1.6 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF2890 PF11081.3 ESL08157.1 - 0.1 12.6 1.7 0.14 12.2 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) COX6C PF02937.10 ESL08158.1 - 0.33 10.8 1.7 0.42 10.5 0.0 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc IF4E PF01652.13 ESL08159.1 - 3.2e-31 108.0 0.0 4.4e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PAM2 PF07145.10 ESL08159.1 - 0.0022 17.3 1.0 0.17 11.4 0.1 2.9 2 0 0 2 2 2 2 Ataxin-2 C-terminal region PSP1 PF04468.7 ESL08160.1 - 5.3e-30 103.2 0.4 5.3e-30 103.2 0.3 1.7 2 0 0 2 2 2 1 PSP1 C-terminal conserved region DUF1707 PF08044.6 ESL08160.1 - 0.12 12.1 0.2 21 4.9 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1707) ABC1 PF03109.11 ESL08161.1 - 2.9e-25 88.5 0.0 5e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 ABC1 family DZR PF12773.2 ESL08164.1 - 0.0037 17.0 1.6 0.13 12.0 0.4 2.8 2 0 0 2 2 2 1 Double zinc ribbon PIF1 PF05970.9 ESL08164.1 - 0.01 14.8 0.0 0.044 12.7 0.0 1.9 2 0 0 2 2 2 0 PIF1-like helicase Sgf11 PF08209.6 ESL08164.1 - 0.023 14.0 2.0 0.82 9.0 0.1 2.5 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) T2SE PF00437.15 ESL08164.1 - 0.053 12.4 0.0 0.081 11.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 ESL08164.1 - 0.067 12.7 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF164 PF02591.10 ESL08164.1 - 0.11 12.3 2.2 0.27 11.0 0.8 2.3 2 0 0 2 2 2 0 Putative zinc ribbon domain 2OG-FeII_Oxy_2 PF13532.1 ESL08165.1 - 1.7e-07 31.3 0.0 8.1e-07 29.0 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESL08165.1 - 0.0012 19.0 0.0 0.003 17.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BAG PF02179.11 ESL08166.1 - 0.00078 19.4 0.1 0.0016 18.4 0.1 1.5 1 0 0 1 1 1 1 BAG domain Med15 PF09606.5 ESL08166.1 - 0.023 12.9 37.6 0.033 12.4 26.1 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 ESL08166.1 - 0.047 11.9 32.6 0.06 11.5 22.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WD40 PF00400.27 ESL08167.1 - 3.9e-10 39.2 0.9 0.033 14.0 0.0 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Nol1_Nop2_Fmu PF01189.12 ESL08168.1 - 1.4e-19 70.5 0.0 1.9e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_18 PF12847.2 ESL08168.1 - 0.018 15.6 0.0 0.036 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESL08168.1 - 0.048 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.20 ESL08169.1 - 1.2e-46 158.9 0.0 1.7e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08169.1 - 3.6e-20 72.1 0.1 1.3e-19 70.2 0.0 1.9 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.18 ESL08169.1 - 0.00039 20.2 0.0 0.00089 19.0 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESL08169.1 - 0.00069 19.2 0.0 0.0032 17.0 0.0 2.0 2 1 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 ESL08169.1 - 0.023 13.7 0.0 0.04 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESL08169.1 - 0.035 13.4 0.0 0.079 12.2 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESL08169.1 - 0.039 12.8 0.0 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF1021 PF06257.6 ESL08170.1 - 0.016 14.9 0.0 0.07 12.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1021) DUF1126 PF06565.7 ESL08171.1 - 1.2e-30 104.6 13.4 1.7e-10 40.2 0.1 5.1 5 0 0 5 5 5 3 Repeat of unknown function (DUF1126) vATP-synt_AC39 PF01992.11 ESL08172.1 - 7.2e-60 202.8 0.0 9e-60 202.5 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Exo_endo_phos PF03372.18 ESL08173.1 - 5.4e-16 59.2 0.0 9.7e-15 55.1 0.0 2.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESL08173.1 - 0.0079 15.8 0.0 4 7.0 0.0 3.0 2 1 0 3 3 3 2 Endonuclease-reverse transcriptase p450 PF00067.17 ESL08174.1 - 9.5e-48 162.8 0.0 1.2e-47 162.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M32 PF02074.10 ESL08175.1 - 1.2e-93 314.4 0.0 1.3e-93 314.3 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase zf-CCCH PF00642.19 ESL08176.1 - 0.0046 16.6 3.2 0.0046 16.6 2.3 3.8 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) EXOSC1 PF10447.4 ESL08177.1 - 1.3e-11 44.2 0.1 4.3e-11 42.6 0.0 1.9 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 TRAM PF01938.15 ESL08177.1 - 0.012 15.3 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 TRAM domain ELO PF01151.13 ESL08178.1 - 1.2e-47 162.3 20.6 1.8e-47 161.7 14.3 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family 5TM-5TMR_LYT PF07694.7 ESL08178.1 - 0.036 13.4 9.3 0.15 11.3 0.6 2.2 2 0 0 2 2 2 0 5TMR of 5TMR-LYT Aminotran_5 PF00266.14 ESL08179.1 - 1.2e-84 284.2 0.0 1.5e-84 283.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESL08179.1 - 4.9e-09 35.7 0.2 7.7e-09 35.0 0.2 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.14 ESL08179.1 - 0.00027 19.5 0.0 0.00047 18.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.12 ESL08179.1 - 0.0023 17.0 0.0 0.004 16.2 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family HMG_box_2 PF09011.5 ESL08180.1 - 3.6e-05 24.0 0.1 3.6e-05 24.0 0.1 2.4 3 0 0 3 3 3 1 HMG-box domain HMG_box PF00505.14 ESL08180.1 - 0.0042 17.3 0.0 0.039 14.2 0.0 2.5 2 0 0 2 2 2 1 HMG (high mobility group) box DUF2686 PF10887.3 ESL08180.1 - 0.07 11.8 0.1 0.13 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2686) E1-E2_ATPase PF00122.15 ESL08181.1 - 9.6e-58 194.9 5.8 9.6e-58 194.9 4.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 ESL08181.1 - 8.8e-24 85.1 0.0 3.1e-23 83.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESL08181.1 - 1.5e-13 49.9 0.0 4.6e-13 48.4 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 ESL08181.1 - 5.3e-13 49.5 0.1 1.7e-12 47.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL08181.1 - 0.00022 20.9 0.1 0.00096 18.7 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL08181.1 - 0.047 13.6 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit RRM_6 PF14259.1 ESL08182.1 - 4.4e-09 36.1 0.0 9.8e-09 35.0 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL08182.1 - 5.6e-08 32.2 0.0 2.9e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08182.1 - 0.00045 20.0 0.0 0.00081 19.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BTB_2 PF02214.17 ESL08183.1 - 2.1e-12 47.0 0.0 4.8e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain RNA_pol_A_bac PF01000.21 ESL08184.1 - 2.9e-22 78.9 0.0 5.5e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 ESL08184.1 - 1.6e-12 46.3 0.0 2e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_7 PF12838.2 ESL08184.1 - 0.015 15.6 4.5 0.033 14.5 0.4 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.1 ESL08184.1 - 0.04 14.1 0.7 0.04 14.1 0.5 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain RcbX PF02341.10 ESL08184.1 - 0.073 13.2 0.1 0.51 10.4 0.0 2.3 1 1 0 1 1 1 0 RbcX protein DUF2401 PF10287.4 ESL08184.1 - 0.091 12.2 0.5 0.14 11.6 0.4 1.3 1 0 0 1 1 1 0 Putative TOS1-like glycosyl hydrolase (DUF2401) Fer4_10 PF13237.1 ESL08184.1 - 0.61 9.9 5.7 0.54 10.0 0.4 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4 PF00037.22 ESL08184.1 - 3.3 7.4 9.2 0.23 11.1 0.3 2.8 3 0 0 3 3 3 0 4Fe-4S binding domain GHMP_kinases_N PF00288.21 ESL08186.1 - 3e-12 46.3 0.3 2e-11 43.7 0.2 2.4 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 ESL08186.1 - 6.3e-06 26.3 0.2 1.9e-05 24.7 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal BNR_3 PF13859.1 ESL08187.1 - 0.0067 15.5 0.0 0.009 15.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain zf-3CxxC PF13695.1 ESL08188.1 - 2.7e-08 33.9 1.9 3.7e-08 33.4 1.3 1.2 1 0 0 1 1 1 1 Zinc-binding domain DEAD PF00270.24 ESL08189.1 - 1.2e-42 145.3 0.1 1.7e-42 144.8 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL08189.1 - 6e-25 86.9 0.3 1.1e-24 86.0 0.2 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESL08189.1 - 0.1 12.7 0.1 0.3 11.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.1 ESL08189.1 - 0.12 11.4 0.1 0.24 10.4 0.1 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit PhoH PF02562.11 ESL08189.1 - 0.12 11.6 0.7 3.6 6.7 0.5 2.5 1 1 0 1 1 1 0 PhoH-like protein Ribosomal_S13 PF00416.17 ESL08190.1 - 6.4e-23 81.2 0.4 7.4e-23 81.0 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 GRASP55_65 PF04495.9 ESL08191.1 - 0.0057 16.6 0.0 0.0095 15.9 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain DUF4239 PF14023.1 ESL08191.1 - 0.12 11.6 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) RIIa PF02197.12 ESL08193.1 - 8.4e-12 44.3 0.1 2.8e-11 42.6 0.1 2.0 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_7 PF13499.1 ESL08193.1 - 0.00011 22.2 0.2 0.0012 18.9 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL08193.1 - 0.041 13.1 0.0 2.1 7.8 0.0 3.0 3 0 0 3 3 3 0 EF hand Aa_trans PF01490.13 ESL08194.1 - 1.9e-58 197.9 28.8 2.3e-58 197.6 20.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL08194.1 - 8.5e-07 28.1 7.4 8.5e-07 28.1 5.1 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family DUF624 PF04854.9 ESL08194.1 - 0.22 11.4 0.0 0.22 11.4 0.0 4.6 4 2 1 5 5 5 0 Protein of unknown function, DUF624 Telomerase_RBD PF12009.3 ESL08195.1 - 2.2e-30 105.3 2.3 4.1e-30 104.4 1.6 1.4 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 ESL08195.1 - 0.19 11.0 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HEAT_2 PF13646.1 ESL08196.1 - 1.9e-08 34.4 3.7 0.0004 20.6 0.0 6.4 5 1 1 6 6 6 2 HEAT repeats HEAT PF02985.17 ESL08196.1 - 2.2e-08 33.5 22.0 0.16 12.1 0.1 8.9 11 0 0 11 11 8 3 HEAT repeat Vac14_Fab1_bd PF12755.2 ESL08196.1 - 5.8e-06 26.5 0.6 0.032 14.6 0.1 4.9 4 1 0 4 4 4 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 ESL08196.1 - 1e-05 25.0 9.2 0.38 10.0 0.1 6.3 4 2 2 6 6 6 2 CLASP N terminal HEAT_EZ PF13513.1 ESL08196.1 - 1.5e-05 25.2 19.8 0.029 14.8 0.0 10.1 11 2 2 13 13 12 1 HEAT-like repeat Adaptin_N PF01602.15 ESL08196.1 - 3.1e-05 22.4 1.0 0.00065 18.1 0.0 3.0 3 2 1 4 4 4 1 Adaptin N terminal region Cnd1 PF12717.2 ESL08196.1 - 9e-05 22.3 3.5 0.0013 18.5 0.1 4.3 4 3 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.1 ESL08196.1 - 0.0054 16.0 0.2 0.41 9.8 0.0 3.1 3 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II CRM1_C PF08767.6 ESL08196.1 - 0.018 13.9 0.2 4.6 6.0 0.0 3.1 2 0 0 2 2 2 0 CRM1 C terminal DUF2435 PF10363.4 ESL08196.1 - 0.021 14.7 4.3 0.32 10.9 0.1 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF2435) Sporozoite_P67 PF05642.6 ESL08196.1 - 1.7 6.4 3.5 0.57 7.9 0.0 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Pro_isomerase PF00160.16 ESL08198.1 - 1.6e-22 80.4 0.0 2.1e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CCDC92 PF14916.1 ESL08199.1 - 0.0032 17.0 4.9 0.099 12.2 0.2 2.8 3 0 0 3 3 3 2 Coiled-coil domain of unknown function DUF972 PF06156.8 ESL08199.1 - 0.011 16.0 3.4 0.16 12.3 2.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF972) HALZ PF02183.13 ESL08199.1 - 0.015 14.9 2.8 0.084 12.6 0.1 3.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper Mod_r PF07200.8 ESL08199.1 - 0.019 14.9 3.2 2.1 8.2 0.1 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein F_actin_bind PF08919.5 ESL08199.1 - 0.035 13.8 4.2 0.067 12.9 0.2 2.6 1 1 1 2 2 2 0 F-actin binding CCDC155 PF14662.1 ESL08199.1 - 0.05 13.1 5.3 0.13 11.8 0.3 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 NYD-SP28_assoc PF14775.1 ESL08199.1 - 0.06 13.0 2.8 0.2 11.4 0.5 2.4 2 0 0 2 2 2 0 Sperm tail C-terminal domain TSC22 PF01166.13 ESL08199.1 - 0.11 12.5 6.5 0.93 9.4 0.0 2.8 3 1 0 3 3 3 0 TSC-22/dip/bun family Atg14 PF10186.4 ESL08199.1 - 0.17 10.8 3.8 0.22 10.4 2.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIVA PF05103.8 ESL08199.1 - 0.23 11.5 2.6 2.7 8.0 1.7 2.4 1 1 0 1 1 1 0 DivIVA protein bZIP_1 PF00170.16 ESL08199.1 - 0.3 11.0 6.0 1.9 8.5 0.1 2.9 2 1 1 3 3 3 0 bZIP transcription factor Rootletin PF15035.1 ESL08199.1 - 1.9 8.3 7.2 2.8 7.8 3.7 2.0 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4200 PF13863.1 ESL08199.1 - 5.1 7.0 7.5 17 5.4 3.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) bZIP_2 PF07716.10 ESL08199.1 - 5.3 6.9 11.0 0.27 11.0 1.8 2.6 3 0 0 3 3 3 0 Basic region leucine zipper DUF904 PF06005.7 ESL08199.1 - 7.9 6.8 7.3 2.8e+02 1.8 5.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) CDC73 PF05179.9 ESL08200.1 - 2.1e-16 60.1 0.0 2.6e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family UCH PF00443.24 ESL08201.1 - 4.4e-42 144.0 0.1 1.2e-41 142.6 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL08201.1 - 1.6e-16 60.6 0.2 7.4e-16 58.4 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GTP_EFTU PF00009.22 ESL08202.1 - 4.1e-38 130.7 0.6 3.9e-37 127.5 0.6 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL08202.1 - 2e-07 30.9 0.0 4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL08202.1 - 1e-06 29.2 0.2 4.9e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein SRPRB PF09439.5 ESL08202.1 - 6.9e-05 22.1 0.1 0.00022 20.5 0.1 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.20 ESL08202.1 - 0.00027 21.0 0.3 0.0097 16.0 0.1 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 ESL08202.1 - 0.0006 19.3 0.1 0.0015 18.0 0.0 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation IF-2 PF11987.3 ESL08202.1 - 0.0011 18.8 0.0 0.0076 16.1 0.0 2.4 3 0 0 3 3 3 1 Translation-initiation factor 2 Dynamin_N PF00350.18 ESL08202.1 - 0.019 14.7 1.4 1.2 8.9 0.0 2.9 2 1 1 3 3 3 0 Dynamin family FeoB_N PF02421.13 ESL08202.1 - 0.048 12.9 0.0 0.088 12.0 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B CDP-OH_P_transf PF01066.16 ESL08203.1 - 2.3e-17 63.1 6.9 2.3e-17 63.1 4.8 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Zeta_toxin PF06414.7 ESL08204.1 - 0.0002 20.5 0.0 0.36 9.8 0.0 2.1 2 0 0 2 2 2 2 Zeta toxin AAA_17 PF13207.1 ESL08204.1 - 0.011 16.5 0.1 0.043 14.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain Methyltransf_18 PF12847.2 ESL08207.1 - 0.13 12.8 0.0 1.4 9.5 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain GTP_EFTU PF00009.22 ESL08208.1 - 1.1e-27 96.6 0.0 1.7e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL08208.1 - 4e-09 37.0 0.0 6.6e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein EFG_II PF14492.1 ESL08208.1 - 4.8e-09 35.9 0.0 8.9e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 ESL08208.1 - 2.4e-07 30.7 0.0 4.6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL08208.1 - 0.00012 21.9 0.1 0.11 12.2 0.0 2.3 1 1 1 2 2 2 2 Dynamin family Ras PF00071.17 ESL08208.1 - 0.00065 19.1 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ESL08208.1 - 0.0027 16.9 0.0 0.0045 16.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.20 ESL08208.1 - 0.017 15.2 0.0 0.043 13.9 0.0 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 2 SPC22 PF04573.7 ESL08209.1 - 2.3e-17 62.7 0.0 2.5e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Signal peptidase subunit DUF607 PF04678.8 ESL08210.1 - 1.5e-23 83.6 0.0 1.8e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF607 KAAG1 PF15354.1 ESL08210.1 - 0.0068 16.7 0.4 0.016 15.5 0.0 1.7 2 0 0 2 2 2 1 Kidney-associated antigen 1 Rap1-DNA-bind PF09197.5 ESL08211.1 - 0.032 14.7 0.0 0.097 13.2 0.0 1.8 2 0 0 2 2 2 0 Rap1, DNA-binding WW PF00397.21 ESL08212.1 - 1.2e-21 76.1 16.0 1.4e-07 31.2 3.0 3.9 4 0 0 4 4 4 3 WW domain SMAP PF15477.1 ESL08213.1 - 1.8e-14 53.7 0.9 3.4e-14 52.8 0.6 1.4 1 0 0 1 1 1 1 Small acidic protein family Exo_endo_phos PF03372.18 ESL08214.1 - 3e-14 53.5 0.2 6.5e-14 52.4 0.1 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family XRN_N PF03159.13 ESL08214.1 - 0.0041 16.5 0.0 0.011 15.1 0.0 1.6 1 1 1 2 2 2 1 XRN 5'-3' exonuclease N-terminus DUF4139 PF13598.1 ESL08215.1 - 4.3e-88 295.6 0.3 1.4e-87 293.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4139) DUF4140 PF13600.1 ESL08215.1 - 5.6e-08 33.1 0.9 5.6e-08 33.1 0.6 2.3 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) Thioredoxin PF00085.15 ESL08216.1 - 0.00043 19.9 0.0 0.00083 18.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL08216.1 - 0.068 13.3 0.0 0.088 13.0 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain AAA PF00004.24 ESL08217.1 - 4.1e-16 59.3 0.0 7.2e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESL08217.1 - 3.2e-12 45.9 0.0 2.2e-09 36.5 0.0 2.2 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein DNA_pol3_delta2 PF13177.1 ESL08217.1 - 1.2e-11 44.5 0.0 7.6e-10 38.6 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 ESL08217.1 - 7.3e-10 38.6 0.0 1.8e-09 37.4 0.0 1.7 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA_22 PF13401.1 ESL08217.1 - 2.7e-07 30.7 0.0 1.8e-06 28.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL08217.1 - 4.2e-07 29.7 0.0 1.7e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESL08217.1 - 3.5e-06 26.9 0.0 1.5e-05 24.8 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.1 ESL08217.1 - 2.3e-05 24.0 0.0 4.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESL08217.1 - 2.7e-05 23.8 0.1 0.0011 18.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 ESL08217.1 - 2.7e-05 23.8 0.0 7.6e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 ESL08217.1 - 7.2e-05 22.8 0.1 0.0015 18.5 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.8 ESL08217.1 - 0.00029 19.8 0.0 0.00047 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NB-ARC PF00931.17 ESL08217.1 - 0.00075 18.4 0.0 0.2 10.4 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_23 PF13476.1 ESL08217.1 - 0.001 19.4 0.0 0.0015 18.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESL08217.1 - 0.0011 18.5 0.0 0.0025 17.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL08217.1 - 0.0012 17.9 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 ESL08217.1 - 0.0018 18.1 0.0 0.0039 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL08217.1 - 0.0032 18.2 0.0 0.0063 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 ESL08217.1 - 0.0047 16.4 0.1 0.024 14.1 0.0 2.0 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_10 PF12846.2 ESL08217.1 - 0.0075 15.7 0.2 0.89 8.9 0.0 2.2 1 1 0 2 2 2 1 AAA-like domain Mg_chelatase PF01078.16 ESL08217.1 - 0.0094 15.1 0.0 0.042 13.0 0.0 1.9 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESL08217.1 - 0.014 15.0 0.0 0.053 13.1 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 ESL08217.1 - 0.016 14.6 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.9 ESL08217.1 - 0.041 13.5 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activ_2 PF14532.1 ESL08217.1 - 0.056 13.4 0.1 0.53 10.3 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 ESL08217.1 - 0.058 13.3 0.1 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESL08217.1 - 0.06 12.3 0.0 0.099 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.17 ESL08217.1 - 0.071 13.2 0.0 0.23 11.6 0.0 1.9 1 0 0 1 1 1 0 RNA helicase SRP54 PF00448.17 ESL08217.1 - 0.076 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.1 ESL08217.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL08217.1 - 0.11 11.8 0.1 0.27 10.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.1 ESL08217.1 - 0.21 11.5 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Lumazine_bd PF12870.2 ESL08218.1 - 4.9 7.2 12.9 0.18 11.8 1.7 2.8 2 1 0 2 2 2 0 Lumazine-binding domain PPR_2 PF13041.1 ESL08221.1 - 3.7e-13 49.2 0.8 1.7e-07 31.0 0.2 3.3 2 1 1 3 3 3 3 PPR repeat family PPR PF01535.15 ESL08221.1 - 5.5e-06 26.0 6.9 0.0015 18.3 0.1 4.4 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.1 ESL08221.1 - 0.00022 21.2 4.8 0.01 16.0 0.1 4.7 4 0 0 4 4 4 1 Pentatricopeptide repeat domain Pkinase PF00069.20 ESL08222.1 - 2.1e-42 145.0 0.0 3e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08222.1 - 1e-23 83.7 0.0 1.6e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESL08222.1 - 3.9e-13 49.0 12.8 1.7e-12 47.0 8.9 2.2 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESL08222.1 - 0.00063 19.5 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESL08222.1 - 0.002 17.5 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 ESL08222.1 - 0.11 12.0 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase EBP PF05241.7 ESL08223.1 - 0.038 12.9 0.0 0.071 12.1 0.0 1.4 1 0 0 1 1 1 0 Emopamil binding protein HTH_28 PF13518.1 ESL08224.1 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Fcf1 PF04900.7 ESL08227.1 - 1.1e-36 124.9 2.3 2.2e-36 123.9 1.6 1.5 1 0 0 1 1 1 1 Fcf1 DUF964 PF06133.6 ESL08228.1 - 0.48 10.4 3.9 0.35 10.8 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF964) DHQ_synthase PF01761.15 ESL08228.1 - 0.98 8.2 5.6 1.7 7.5 3.9 1.5 1 1 0 1 1 1 0 3-dehydroquinate synthase Epiglycanin_C PF14654.1 ESL08228.1 - 2.7 8.0 11.7 4.3 7.3 8.1 1.2 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region NicO PF03824.11 ESL08228.1 - 3.8 6.7 6.0 5.5 6.2 4.2 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein ACBP PF00887.14 ESL08229.1 - 1.5e-24 85.4 0.0 2.9e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein OsmC PF02566.14 ESL08231.1 - 0.0041 17.2 0.0 0.008 16.3 0.0 1.4 1 1 0 1 1 1 1 OsmC-like protein Peptidase_M3 PF01432.15 ESL08232.1 - 1.9e-113 379.9 0.0 2.7e-113 379.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 ESL08232.1 - 0.053 12.8 0.1 0.096 12.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like BPL_LplA_LipB PF03099.14 ESL08233.1 - 1.8e-17 63.5 0.0 4.4e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HEAT_EZ PF13513.1 ESL08234.1 - 0.0009 19.6 4.9 0.43 11.1 0.0 5.1 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.17 ESL08234.1 - 0.0062 16.5 5.1 2.9 8.1 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.1 ESL08234.1 - 0.011 15.9 0.1 0.011 15.9 0.1 3.7 4 1 0 4 4 4 0 HEAT repeats Arm PF00514.18 ESL08234.1 - 0.038 13.8 3.6 4.8 7.1 0.0 4.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat IBN_N PF03810.14 ESL08234.1 - 0.46 10.4 3.7 1.8 8.5 0.1 3.3 3 1 0 3 3 3 0 Importin-beta N-terminal domain Radical_SAM PF04055.16 ESL08235.1 - 5.3e-15 55.9 0.0 2.3e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 ESL08235.1 - 1.8e-08 34.2 0.2 6.6e-08 32.4 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESL08235.1 - 0.084 12.9 0.1 0.21 11.7 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SET PF00856.23 ESL08236.1 - 3.1e-07 30.8 0.0 1.5e-06 28.5 0.0 2.0 2 1 0 2 2 2 1 SET domain SAF PF08666.7 ESL08236.1 - 0.09 13.1 0.0 0.35 11.3 0.0 2.0 2 0 0 2 2 2 0 SAF domain His_Phos_1 PF00300.17 ESL08237.1 - 1.8e-29 102.9 0.0 4e-29 101.7 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 ESL08237.1 - 0.038 13.3 0.0 0.1 11.9 0.0 1.6 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 2) TPR_11 PF13414.1 ESL08240.1 - 7.1e-13 48.0 10.8 0.018 14.6 0.0 4.9 3 2 1 5 5 5 4 TPR repeat TPR_16 PF13432.1 ESL08240.1 - 8.4e-13 48.6 12.0 0.0013 19.3 0.3 4.5 4 2 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08240.1 - 4.4e-12 44.9 9.0 0.033 14.0 0.0 6.3 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08240.1 - 8.4e-10 37.8 1.6 0.068 12.8 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL08240.1 - 4.7e-09 36.4 9.8 0.00053 20.2 0.1 4.2 4 1 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESL08240.1 - 1e-08 34.6 5.0 0.64 10.3 0.0 6.2 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL08240.1 - 1.3e-07 31.6 15.3 0.34 11.6 0.0 6.4 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08240.1 - 5.3e-07 29.4 13.1 0.1 12.5 0.8 5.4 2 1 4 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08240.1 - 1.1e-05 24.8 2.5 0.23 11.3 0.0 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08240.1 - 0.003 17.2 12.4 0.44 10.4 0.1 5.9 6 2 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESL08240.1 - 0.058 12.4 3.8 5 6.1 0.0 3.4 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08240.1 - 0.28 11.7 10.4 18 6.0 0.1 5.3 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESL08240.1 - 1.9 8.3 10.1 3.3 7.6 0.4 4.3 2 2 3 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL08240.1 - 4.2 7.5 11.8 4.7 7.4 0.8 3.9 2 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Topo_C_assoc PF14370.1 ESL08241.1 - 0.033 13.8 0.1 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 C-terminal topoisomerase domain RNA_pol_Rpc4 PF05132.9 ESL08242.1 - 2.8e-11 43.5 0.9 1.2e-09 38.2 0.0 2.8 2 1 1 3 3 3 2 RNA polymerase III RPC4 Asparaginase PF00710.15 ESL08244.1 - 6.2e-69 232.2 0.0 7.4e-69 231.9 0.0 1.0 1 0 0 1 1 1 1 Asparaginase DcpS_C PF11969.3 ESL08245.1 - 1.7e-06 28.2 0.0 3.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding PUF PF00806.14 ESL08246.1 - 9.1e-33 109.9 7.3 1.3e-05 24.4 0.1 7.5 7 0 0 7 7 7 6 Pumilio-family RNA binding repeat Guanylin PF02058.10 ESL08246.1 - 0.013 15.5 0.4 4.5 7.4 0.1 2.8 1 1 1 2 2 2 0 Guanylin precursor SpoVIF PF14069.1 ESL08246.1 - 0.075 12.7 0.1 0.47 10.2 0.1 2.3 2 0 0 2 2 2 0 Stage VI sporulation protein F UPF0546 PF10639.4 ESL08247.1 - 2.7e-35 120.6 0.2 3e-35 120.4 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0546 EamA PF00892.15 ESL08247.1 - 4.6e-05 23.4 1.2 4.6e-05 23.4 0.8 1.8 2 0 0 2 2 2 1 EamA-like transporter family TPT PF03151.11 ESL08247.1 - 0.047 13.3 1.8 0.067 12.8 1.3 1.6 1 1 0 1 1 1 0 Triose-phosphate Transporter family WD40 PF00400.27 ESL08248.1 - 2.5e-07 30.3 10.7 0.00021 21.0 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Peptidase_M41 PF01434.13 ESL08249.1 - 1.2e-43 149.1 0.1 1.6e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESL08249.1 - 1.5e-39 135.2 0.1 4.1e-39 133.8 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESL08249.1 - 3.6e-05 23.2 0.1 0.36 10.1 0.1 2.9 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.7 ESL08249.1 - 0.00013 21.0 0.0 0.00053 19.0 0.0 2.1 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESL08249.1 - 0.0002 21.0 0.0 0.0011 18.6 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_2 PF07724.9 ESL08249.1 - 0.00024 21.0 0.0 0.00057 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL08249.1 - 0.00047 20.3 0.0 0.035 14.2 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL08249.1 - 0.00096 19.9 0.0 0.0027 18.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL08249.1 - 0.0015 18.5 0.3 0.02 14.8 0.1 2.4 2 1 1 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.12 ESL08249.1 - 0.002 17.5 0.0 0.0044 16.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESL08249.1 - 0.0024 17.7 0.0 0.0084 16.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESL08249.1 - 0.0025 16.5 0.0 0.004 15.9 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 ESL08249.1 - 0.013 15.1 0.2 0.083 12.6 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESL08249.1 - 0.014 14.6 0.0 0.066 12.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 ESL08249.1 - 0.14 12.4 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain BRK PF07533.11 ESL08250.1 - 0.042 13.3 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 BRK domain SMC_N PF02463.14 ESL08251.1 - 3.2e-59 199.8 0.0 1.2e-58 197.9 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESL08251.1 - 3.5e-17 62.4 0.8 3.7e-16 59.1 0.0 2.7 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 ESL08251.1 - 8e-15 55.7 0.1 8e-15 55.7 0.0 5.1 2 2 1 3 3 1 1 AAA domain AAA_21 PF13304.1 ESL08251.1 - 5.3e-14 52.8 0.0 1.6e-06 28.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESL08251.1 - 0.00015 21.1 0.0 0.00037 19.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 ESL08251.1 - 0.0022 17.1 0.1 0.021 13.8 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain DUF948 PF06103.6 ESL08251.1 - 0.0085 15.9 9.2 0.045 13.6 1.5 4.5 4 0 0 4 4 4 1 Bacterial protein of unknown function (DUF948) ABC_tran PF00005.22 ESL08251.1 - 0.021 15.0 15.2 0.065 13.5 0.3 5.2 4 3 0 4 4 4 0 ABC transporter Reo_sigmaC PF04582.7 ESL08251.1 - 0.026 13.6 10.6 0.042 13.0 0.9 3.9 2 2 2 4 4 4 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 ESL08251.1 - 0.4 10.4 9.7 0.79 9.5 2.6 3.9 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus LXG PF04740.7 ESL08251.1 - 6.2 6.5 19.5 0.016 14.9 3.0 3.7 4 1 0 4 4 4 0 LXG domain of WXG superfamily SNF2_N PF00176.18 ESL08253.1 - 1.5e-67 227.4 0.1 2.4e-67 226.8 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL08253.1 - 7.4e-13 48.1 0.0 2.8e-12 46.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL08253.1 - 0.0017 18.2 0.0 0.0062 16.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 ESL08253.1 - 0.0018 17.1 0.0 0.15 10.8 0.0 2.2 2 0 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 AAA_11 PF13086.1 ESL08253.1 - 0.003 17.1 4.0 0.15 11.6 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.1 ESL08253.1 - 0.015 15.4 1.3 0.052 13.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.22 ESL08254.1 - 2e-12 47.5 0.0 1.4e-11 44.8 0.0 2.2 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESL08254.1 - 6.5e-07 29.5 0.0 0.028 14.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESL08254.1 - 1.9e-05 24.7 0.0 7.2e-05 22.8 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESL08254.1 - 0.00015 21.4 0.2 0.0089 15.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESL08254.1 - 0.00054 20.7 0.0 0.0019 19.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL08254.1 - 0.00071 19.7 0.0 0.0032 17.5 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 ESL08254.1 - 0.0016 17.8 0.4 0.088 12.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESL08254.1 - 0.0017 18.0 3.0 0.0023 17.6 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 ESL08254.1 - 0.0019 18.1 0.7 0.015 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESL08254.1 - 0.0091 16.2 0.2 0.023 14.9 0.0 1.7 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 ESL08254.1 - 0.011 15.4 0.0 0.026 14.1 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 ESL08254.1 - 0.019 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESL08254.1 - 0.035 14.4 0.0 0.057 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 ESL08254.1 - 0.041 13.1 0.0 0.73 9.0 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA PF00004.24 ESL08254.1 - 0.041 14.0 0.1 0.23 11.6 0.1 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 ESL08254.1 - 0.059 12.2 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.1 ESL08254.1 - 0.066 13.0 0.2 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 ESL08254.1 - 0.083 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Arch_ATPase PF01637.13 ESL08254.1 - 0.098 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase MobB PF03205.9 ESL08254.1 - 0.14 11.8 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.10 ESL08254.1 - 0.15 10.6 0.1 0.23 10.1 0.1 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_10 PF12846.2 ESL08254.1 - 0.18 11.2 0.0 0.47 9.8 0.0 1.6 1 0 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.17 ESL08254.1 - 0.28 11.3 0.0 0.84 9.8 0.0 1.8 2 0 0 2 2 1 0 RNA helicase Adeno_IVa2 PF02456.10 ESL08254.1 - 0.43 9.1 0.0 0.71 8.4 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein Ribosomal_S10 PF00338.17 ESL08255.1 - 3.5e-23 81.2 0.0 4.1e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PBP PF01161.15 ESL08257.1 - 4.3e-07 29.8 0.0 1.6e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylethanolamine-binding protein Aminotran_1_2 PF00155.16 ESL08258.1 - 9.3e-71 238.6 0.0 1.1e-70 238.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Arc_PepC PF06819.6 ESL08258.1 - 0.036 13.9 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain Fe_hyd_lg_C PF02906.9 ESL08259.1 - 4.2e-69 232.9 0.0 5.5e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain PseudoU_synth_2 PF00849.17 ESL08260.1 - 1.9e-23 83.0 0.0 3e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_C12 PF01088.16 ESL08261.1 - 4.2e-58 196.0 0.0 4.8e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 EF-hand_9 PF14658.1 ESL08261.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain FGGY_N PF00370.16 ESL08262.1 - 4.6e-80 268.4 0.0 6e-80 268.0 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 ESL08262.1 - 9.1e-33 113.5 1.4 1.6e-32 112.7 1.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.15 ESL08262.1 - 0.02 14.1 0.0 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Mito_carr PF00153.22 ESL08263.1 - 6.5e-07 28.9 6.0 0.13 12.0 0.1 4.8 3 2 1 4 4 4 4 Mitochondrial carrier protein DUF204 PF02659.10 ESL08263.1 - 0.041 13.9 1.1 0.24 11.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF RCC1 PF00415.13 ESL08265.1 - 8.7e-17 61.0 25.6 2.8e-08 33.8 0.0 7.3 6 3 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL08265.1 - 5.5e-15 54.5 23.3 3.3e-06 26.5 0.3 6.3 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Kelch_3 PF13415.1 ESL08266.1 - 4.6e-26 90.3 14.3 5e-07 29.7 0.0 7.5 7 0 0 7 7 7 7 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL08266.1 - 4.1e-24 84.0 13.1 3.7e-06 26.7 0.4 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 ESL08266.1 - 1.4e-18 66.2 9.3 0.0008 19.4 0.2 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESL08266.1 - 6.6e-15 54.6 17.6 0.00011 21.9 0.2 7.3 4 2 2 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESL08266.1 - 1.4e-13 50.1 8.9 3.3e-05 23.3 0.2 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESL08266.1 - 4.8e-08 32.4 13.0 0.072 12.8 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Ribosomal_L34e PF01199.13 ESL08267.1 - 2.6e-29 101.2 4.6 2.6e-29 101.2 3.2 2.4 2 1 0 2 2 2 1 Ribosomal protein L34e DUF2762 PF10960.3 ESL08267.1 - 7.7 6.3 7.5 14 5.4 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) RNase_T PF00929.19 ESL08268.1 - 7.3e-06 26.3 0.0 1.2e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Exonuclease Metal_resist PF13801.1 ESL08269.1 - 0.022 14.7 0.0 0.022 14.7 0.0 3.5 2 1 1 3 3 3 0 Heavy-metal resistance Fzo_mitofusin PF04799.8 ESL08269.1 - 0.031 13.6 5.7 0.033 13.5 2.4 2.1 3 0 0 3 3 3 0 fzo-like conserved region DUF3584 PF12128.3 ESL08269.1 - 0.53 7.5 14.9 1.3 6.2 7.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.6 ESL08269.1 - 3.8 6.0 8.8 7 5.2 6.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.7 ESL08269.1 - 3.8 7.2 10.3 0.19 11.5 2.6 2.1 3 0 0 3 3 3 0 Laminin Domain II Asn_synthase PF00733.16 ESL08270.1 - 1.2e-31 110.1 0.0 1.8e-19 70.2 0.0 2.3 2 0 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.1 ESL08270.1 - 0.034 13.8 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain PARP_regulatory PF01358.13 ESL08272.1 - 1.5e-18 66.4 0.0 6.1e-13 48.0 0.0 2.1 2 0 0 2 2 2 2 Poly A polymerase regulatory subunit MFS_1 PF07690.11 ESL08273.1 - 2.3e-26 92.3 73.4 1.5e-22 79.8 33.8 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily Pkinase PF00069.20 ESL08276.1 - 1e-52 178.8 0.0 4.8e-36 124.2 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08276.1 - 2.3e-32 112.0 0.0 9.5e-32 110.0 0.0 1.9 1 1 2 3 3 3 1 Protein tyrosine kinase Kdo PF06293.9 ESL08276.1 - 0.015 14.4 0.0 0.037 13.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Disulph_isomer PF06491.6 ESL08278.1 - 0.04 13.7 1.5 0.093 12.5 1.0 1.6 1 0 0 1 1 1 0 Disulphide isomerase SlyX PF04102.7 ESL08279.1 - 0.084 13.2 0.4 0.26 11.6 0.1 1.8 2 0 0 2 2 2 0 SlyX TBCA PF02970.11 ESL08280.1 - 3.4e-23 81.5 6.4 4.9e-23 81.0 3.9 1.6 1 1 1 2 2 2 1 Tubulin binding cofactor A ChlI PF13541.1 ESL08280.1 - 0.076 12.5 0.5 0.85 9.1 0.0 2.1 1 1 1 2 2 2 0 Subunit ChlI of Mg-chelatase Striatin PF08232.7 ESL08280.1 - 0.14 12.5 3.7 0.17 12.1 2.6 1.1 1 0 0 1 1 1 0 Striatin family Met_10 PF02475.11 ESL08280.1 - 0.14 11.7 0.9 0.21 11.1 0.6 1.3 1 1 0 1 1 1 0 Met-10+ like-protein Spc7 PF08317.6 ESL08280.1 - 0.84 8.2 8.3 0.27 9.8 2.2 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF972 PF06156.8 ESL08280.1 - 6.7 7.1 6.6 19 5.6 4.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) GAF_3 PF13492.1 ESL08281.1 - 0.0094 16.0 0.0 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 GAF domain CALCOCO1 PF07888.6 ESL08282.1 - 0.0068 14.7 1.3 0.0068 14.7 0.9 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.7 ESL08282.1 - 0.012 15.3 1.4 0.024 14.3 1.0 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1811 PF08838.5 ESL08282.1 - 0.17 11.8 1.0 0.46 10.4 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1811) Cpn60_TCP1 PF00118.19 ESL08283.1 - 1.9e-75 254.3 2.6 2.1e-75 254.1 1.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2493 PF10686.4 ESL08283.1 - 0.11 12.0 0.1 0.8 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2493) Galactosyl_T PF01762.16 ESL08284.1 - 1.1e-07 31.7 0.0 0.0046 16.5 0.0 3.3 3 0 0 3 3 3 3 Galactosyltransferase DnaJ PF00226.26 ESL08285.1 - 1.2e-22 79.3 0.2 1.5e-22 79.1 0.2 1.1 1 0 0 1 1 1 1 DnaJ domain Pribosyltran PF00156.22 ESL08287.1 - 1.7e-17 63.2 0.0 2.3e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESL08287.1 - 0.00015 21.0 0.0 0.0002 20.6 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 ESL08287.1 - 0.0043 16.3 0.1 0.007 15.6 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase Peptidase_S9_N PF02897.10 ESL08289.1 - 5.7e-115 384.1 0.0 7.5e-115 383.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.16 ESL08289.1 - 1.9e-66 223.3 0.0 2.7e-66 222.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family peroxidase PF00141.18 ESL08290.1 - 4.2e-08 32.9 0.0 6.7e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Peroxidase DEAD PF00270.24 ESL08291.1 - 1e-37 129.1 0.1 8.7e-37 126.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL08291.1 - 1.7e-27 95.0 0.5 9.7e-27 92.6 0.2 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1460 PF07313.7 ESL08291.1 - 0.0068 15.6 0.1 1.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1460) CMS1 PF14617.1 ESL08291.1 - 0.0083 15.2 0.1 0.034 13.2 0.0 2.0 2 1 1 3 3 3 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.1 ESL08291.1 - 0.027 14.6 0.7 0.14 12.2 0.0 2.5 3 1 0 3 3 3 0 AAA domain SAM_1 PF00536.25 ESL08292.1 - 0.0012 18.9 0.0 0.003 17.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESL08292.1 - 0.0031 17.3 0.1 0.0086 15.9 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Intein_splicing PF14890.1 ESL08292.1 - 0.049 12.5 0.0 0.09 11.6 0.0 1.3 1 0 0 1 1 1 0 Intein splicing domain DUF2273 PF10031.4 ESL08293.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) FtsJ PF01728.14 ESL08294.1 - 1.4e-63 214.1 0.0 1.8e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 ESL08294.1 - 0.02 15.4 0.1 0.057 14.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain SpoU_methylase PF00588.14 ESL08295.1 - 5.6e-24 84.6 0.0 1.6e-23 83.1 0.0 1.7 2 0 0 2 2 2 1 SpoU rRNA Methylase family V_ATPase_I PF01496.14 ESL08296.1 - 4.3e-212 706.0 10.2 2.6e-211 703.4 7.1 1.8 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family Pkinase PF00069.20 ESL08299.1 - 6.5e-42 143.4 0.0 9.9e-26 90.4 0.0 3.6 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08299.1 - 1.1e-20 73.8 0.0 6.4e-07 28.7 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Kelch_1 PF01344.20 ESL08299.1 - 6.8e-05 22.3 0.0 0.0022 17.5 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Ribosomal_S19 PF00203.16 ESL08300.1 - 5.3e-28 96.4 0.3 9.4e-28 95.6 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S19 PmbA_TldD PF01523.11 ESL08300.1 - 0.023 13.9 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Sugar_tr PF00083.19 ESL08301.1 - 2.5e-45 154.8 20.2 2.8e-45 154.7 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Syndecan PF01034.15 ESL08301.1 - 0.03 13.9 0.3 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 Syndecan domain PMP22_Claudin PF00822.15 ESL08301.1 - 0.13 11.8 4.0 0.29 10.7 2.7 1.7 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family NfeD PF01957.13 ESL08301.1 - 1.2 9.2 8.3 0.95 9.5 0.2 2.3 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding RNA_pol_Rpb2_2 PF04561.9 ESL08302.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 2 AAA PF00004.24 ESL08304.1 - 2.5e-50 170.0 0.0 1.3e-37 128.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 ESL08304.1 - 1.7e-19 69.6 0.7 3.3e-19 68.7 0.5 1.5 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_22 PF13401.1 ESL08304.1 - 2e-10 40.9 1.5 0.00096 19.3 0.3 3.9 2 2 1 3 3 3 2 AAA domain AAA_16 PF13191.1 ESL08304.1 - 8.9e-09 35.5 7.1 0.0023 17.9 0.1 4.4 3 2 1 4 4 3 2 AAA ATPase domain AAA_33 PF13671.1 ESL08304.1 - 5.4e-08 32.8 0.0 0.003 17.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESL08304.1 - 2.8e-07 30.3 0.0 0.0027 17.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESL08304.1 - 3.2e-07 30.3 0.0 0.0024 17.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 ESL08304.1 - 9.2e-07 28.4 0.1 0.046 13.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Arch_ATPase PF01637.13 ESL08304.1 - 2.8e-06 27.1 0.0 0.083 12.5 0.0 3.4 2 1 1 3 3 3 1 Archaeal ATPase T2SE PF00437.15 ESL08304.1 - 6.3e-06 25.2 0.0 0.062 12.1 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_2 PF07724.9 ESL08304.1 - 7.4e-06 25.9 0.0 0.00028 20.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 ESL08304.1 - 7.6e-06 26.7 0.1 0.0061 17.3 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESL08304.1 - 8e-06 25.8 0.0 0.016 15.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 ESL08304.1 - 1e-05 25.0 8.1 3 7.1 0.0 5.2 2 2 3 5 5 5 1 AAA domain NACHT PF05729.7 ESL08304.1 - 1.2e-05 25.0 4.3 0.39 10.3 0.0 4.2 4 1 1 5 5 4 2 NACHT domain ABC_tran PF00005.22 ESL08304.1 - 2.8e-05 24.4 0.9 0.14 12.4 0.0 3.5 2 1 1 3 3 3 1 ABC transporter RNA_helicase PF00910.17 ESL08304.1 - 5.5e-05 23.2 0.0 0.03 14.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.8 ESL08304.1 - 5.8e-05 22.1 0.1 0.12 11.2 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESL08304.1 - 0.00019 21.1 0.6 0.15 11.8 0.0 3.1 3 0 0 3 3 2 1 Part of AAA domain Sigma54_activ_2 PF14532.1 ESL08304.1 - 0.00031 20.7 0.0 0.28 11.2 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_29 PF13555.1 ESL08304.1 - 0.00034 20.0 0.4 0.43 10.1 0.2 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain ATP-synt_ab PF00006.20 ESL08304.1 - 0.00036 20.0 0.0 0.3 10.5 0.0 2.4 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain RuvB_N PF05496.7 ESL08304.1 - 0.00042 19.4 0.0 0.95 8.4 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus NB-ARC PF00931.17 ESL08304.1 - 0.00043 19.2 0.2 0.15 10.8 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain Zeta_toxin PF06414.7 ESL08304.1 - 0.00063 18.8 0.0 0.23 10.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin DUF258 PF03193.11 ESL08304.1 - 0.0013 17.9 0.1 0.11 11.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Mg_chelatase PF01078.16 ESL08304.1 - 0.0015 17.7 0.2 1.1 8.3 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESL08304.1 - 0.0034 16.8 0.1 2.2 7.7 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain MobB PF03205.9 ESL08304.1 - 0.0054 16.4 1.2 0.41 10.3 0.1 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.10 ESL08304.1 - 0.0094 15.6 0.4 1 9.0 0.1 2.7 2 0 0 2 2 2 1 NTPase UPF0079 PF02367.12 ESL08304.1 - 0.0095 15.5 0.2 1 8.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_24 PF13479.1 ESL08304.1 - 0.013 15.0 2.5 0.42 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESL08304.1 - 0.032 13.6 0.9 2.4 7.5 0.0 2.6 3 0 0 3 3 2 0 AAA-like domain Miro PF08477.8 ESL08304.1 - 0.037 14.5 0.6 8.2 6.9 0.1 3.3 4 0 0 4 4 2 0 Miro-like protein AAA_18 PF13238.1 ESL08304.1 - 0.042 14.1 0.1 9.8 6.4 0.0 3.2 3 0 0 3 3 2 0 AAA domain Bac_DnaA PF00308.13 ESL08304.1 - 0.043 13.4 0.1 4.9 6.7 0.0 3.5 4 0 0 4 4 4 0 Bacterial dnaA protein Vps4_C PF09336.5 ESL08304.1 - 0.046 13.6 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain PduV-EutP PF10662.4 ESL08304.1 - 0.059 12.8 0.2 6.9 6.1 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PIF1 PF05970.9 ESL08304.1 - 0.11 11.3 0.1 7 5.4 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase FtsK_SpoIIIE PF01580.13 ESL08304.1 - 0.11 11.9 0.1 1.4 8.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family KaiC PF06745.8 ESL08304.1 - 0.15 11.1 0.1 9.2 5.3 0.0 2.6 2 0 0 2 2 2 0 KaiC Septin PF00735.13 ESL08304.1 - 0.18 10.7 0.2 7.8 5.4 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_23 PF13476.1 ESL08304.1 - 0.24 11.7 0.6 22 5.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF3317 PF11779.3 ESL08305.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) SNF2_N PF00176.18 ESL08306.1 - 1.9e-26 92.5 0.0 3.1e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL08306.1 - 8.4e-13 47.9 0.0 3.7e-12 45.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL08306.1 - 0.0032 17.3 0.0 2.7 7.7 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit NUP50 PF08911.6 ESL08306.1 - 0.096 13.0 4.8 0.29 11.5 3.3 1.9 1 0 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) SR-25 PF10500.4 ESL08306.1 - 2.5 7.5 20.8 4.3 6.7 14.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Metallophos PF00149.23 ESL08307.1 - 4.7e-18 65.3 0.0 1e-17 64.2 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pkinase PF00069.20 ESL08308.1 - 2.8e-54 184.0 0.0 4e-54 183.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08308.1 - 7.4e-35 120.2 0.0 1.5e-34 119.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08308.1 - 1.3e-06 27.6 0.0 1.3e-05 24.3 0.0 2.1 1 1 1 2 2 2 1 Kinase-like PH PF00169.24 ESL08308.1 - 5.2e-06 26.5 0.0 5.8e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 PH domain PH_9 PF15410.1 ESL08308.1 - 0.011 15.9 0.0 0.045 13.9 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain ESSS PF10183.4 ESL08309.1 - 1.1e-14 54.7 3.8 1.2e-14 54.5 2.7 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) V_ATPase_I PF01496.14 ESL08311.1 - 1.6e-188 628.1 1.5 2e-188 627.8 1.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family FTCD_C PF04961.7 ESL08311.1 - 0.039 13.3 0.3 0.18 11.2 0.2 2.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF1615 PF07759.7 ESL08311.1 - 0.085 11.6 0.2 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) Ufd2P_core PF10408.4 ESL08311.1 - 6 4.9 8.7 0.16 10.2 1.3 1.6 2 0 0 2 2 2 0 Ubiquitin elongating factor core fn3 PF00041.16 ESL08312.1 - 3.7e-11 42.9 0.1 0.00035 20.6 0.0 4.2 3 0 0 3 3 3 3 Fibronectin type III domain BRCA-2_OB1 PF09103.5 ESL08313.1 - 5.5e-32 109.9 0.0 9.5e-32 109.1 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 DUF4336 PF14234.1 ESL08315.1 - 0.0033 16.6 0.5 0.16 11.1 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4336) DUF3880 PF12996.2 ESL08315.1 - 0.055 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 DUF based on E. rectale Gene description (DUF3880) DEAD PF00270.24 ESL08317.1 - 1.4e-14 53.9 0.0 4.4e-14 52.3 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL08317.1 - 1.2e-08 34.7 0.0 2.9e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL08317.1 - 4.7e-06 26.5 0.0 1.2e-05 25.2 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESL08317.1 - 0.00072 19.6 0.0 0.031 14.4 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.1 ESL08317.1 - 0.0012 18.2 0.1 0.17 11.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESL08317.1 - 0.0036 16.7 0.0 0.01 15.2 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.1 ESL08317.1 - 0.013 15.2 0.0 0.036 13.7 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain SecA_DEAD PF07517.9 ESL08317.1 - 0.034 13.4 0.0 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain PhoH PF02562.11 ESL08317.1 - 0.047 12.9 0.0 0.09 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.1 ESL08317.1 - 0.11 12.1 0.0 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Reo_sigmaC PF04582.7 ESL08318.1 - 0.078 12.1 2.0 0.1 11.7 1.4 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Spc7 PF08317.6 ESL08318.1 - 4 6.0 7.2 12 4.4 0.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.1 ESL08318.1 - 5.9 6.8 10.3 10 6.1 0.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) FUN14 PF04930.10 ESL08319.1 - 8.9e-19 67.6 2.0 1.4e-18 67.0 1.4 1.3 1 0 0 1 1 1 1 FUN14 family EF-hand_5 PF13202.1 ESL08319.1 - 0.049 12.9 0.1 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.27 ESL08319.1 - 0.12 11.7 0.3 0.23 10.8 0.2 1.5 1 0 0 1 1 1 0 EF hand TPR_16 PF13432.1 ESL08320.1 - 2.9e-29 101.0 9.5 1.5e-06 28.7 1.1 8.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESL08320.1 - 1.4e-26 90.5 24.6 0.00045 20.6 0.1 12.1 8 3 6 14 14 12 6 Tetratricopeptide repeat TPR_19 PF14559.1 ESL08320.1 - 7.9e-26 90.1 9.7 6.1e-07 29.6 0.2 8.8 6 2 2 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.1 ESL08320.1 - 2e-25 88.2 19.9 6.5e-08 32.1 0.1 7.5 6 2 3 9 9 8 7 TPR repeat TPR_2 PF07719.12 ESL08320.1 - 1.3e-18 65.2 24.7 0.00033 20.3 0.0 11.5 14 0 0 14 14 10 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08320.1 - 9.1e-17 59.8 12.8 3.1e-06 26.5 0.0 10.3 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08320.1 - 1.2e-16 60.3 17.3 0.00019 21.3 0.2 8.5 5 2 5 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08320.1 - 1.2e-13 49.7 3.8 0.002 17.7 0.0 8.7 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08320.1 - 2.1e-11 42.7 16.3 0.058 13.2 0.0 9.8 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08320.1 - 2.7e-09 36.8 9.3 0.34 11.4 0.0 9.6 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESL08320.1 - 6e-07 29.1 3.2 0.35 11.1 0.0 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat RPN7 PF10602.4 ESL08320.1 - 9e-05 21.9 4.5 0.054 12.8 0.4 4.9 3 2 0 4 4 4 1 26S proteasome subunit RPN7 TPR_20 PF14561.1 ESL08320.1 - 0.0027 17.7 2.5 5 7.2 0.0 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESL08320.1 - 0.003 16.6 5.4 0.12 11.4 0.0 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.4 ESL08320.1 - 0.0033 17.3 9.9 4 7.3 0.0 5.1 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL08320.1 - 0.0056 16.5 12.9 11 6.0 0.1 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat SNAP PF14938.1 ESL08320.1 - 0.45 9.6 12.3 0.71 8.9 0.1 4.1 3 2 1 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_4 PF07721.9 ESL08320.1 - 0.85 10.2 17.8 32 5.3 0.3 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat NARP1 PF12569.3 ESL08320.1 - 5.7 5.5 14.4 1.8 7.2 0.1 3.8 4 1 0 4 4 4 0 NMDA receptor-regulated protein 1 DUF202 PF02656.10 ESL08321.1 - 1e-15 57.6 1.6 2e-14 53.5 0.5 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF202) PseudoU_synth_1 PF01416.15 ESL08322.1 - 8.8e-27 93.5 0.0 9.9e-19 67.7 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF3287 PF11690.3 ESL08323.1 - 0.0039 17.2 2.7 0.01 15.9 1.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3287) Transglut_core PF01841.14 ESL08323.1 - 0.02 15.1 0.1 2.8 8.1 0.0 2.7 2 0 0 2 2 2 0 Transglutaminase-like superfamily Ank_2 PF12796.2 ESL08324.1 - 1.4e-62 208.0 12.7 2.9e-15 56.3 0.1 10.6 7 5 3 11 11 11 10 Ankyrin repeats (3 copies) Ank PF00023.25 ESL08324.1 - 1.3e-47 157.2 47.2 8.3e-07 28.5 0.3 17.8 19 1 0 19 19 19 13 Ankyrin repeat Ank_4 PF13637.1 ESL08324.1 - 2.3e-46 155.3 18.7 1.1e-09 38.5 0.1 13.7 10 5 4 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL08324.1 - 6.8e-44 143.4 27.0 0.00012 22.0 0.1 18.0 18 0 0 18 18 18 12 Ankyrin repeat Ank_5 PF13857.1 ESL08324.1 - 1.1e-37 127.1 41.3 1.6e-05 25.0 0.3 15.4 10 4 7 18 18 18 10 Ankyrin repeats (many copies) AARP2CN PF08142.7 ESL08325.1 - 7.1e-25 86.3 0.0 1.7e-24 85.1 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_16 PF13191.1 ESL08325.1 - 3.3e-05 23.9 0.0 8.3e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESL08325.1 - 3.8e-05 23.8 0.0 0.0001 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 ESL08325.1 - 0.00015 21.2 0.0 0.0061 16.0 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MobB PF03205.9 ESL08325.1 - 0.00016 21.4 0.0 0.0004 20.0 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESL08325.1 - 0.00016 21.5 0.0 0.00054 19.8 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESL08325.1 - 0.0013 19.5 0.1 0.011 16.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 ESL08325.1 - 0.0022 18.3 0.0 0.0087 16.3 0.0 2.0 1 0 0 1 1 1 1 ABC transporter AAA_10 PF12846.2 ESL08325.1 - 0.0027 17.2 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_30 PF13604.1 ESL08325.1 - 0.0035 16.9 0.0 0.0081 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL08325.1 - 0.0058 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESL08325.1 - 0.006 16.4 0.8 0.012 15.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain Miro PF08477.8 ESL08325.1 - 0.0092 16.4 0.0 0.024 15.1 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein ATP_bind_1 PF03029.12 ESL08325.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.10 ESL08325.1 - 0.012 15.3 0.1 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 NTPase DUF258 PF03193.11 ESL08325.1 - 0.014 14.5 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA PF00004.24 ESL08325.1 - 0.018 15.2 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 ESL08325.1 - 0.019 14.6 0.1 0.064 12.9 0.0 1.8 1 1 1 2 2 2 0 Archaeal ATPase AAA_19 PF13245.1 ESL08325.1 - 0.023 14.4 0.2 0.057 13.1 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 ESL08325.1 - 0.033 13.8 0.0 0.068 12.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 ESL08325.1 - 0.044 14.0 0.0 0.25 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 ESL08325.1 - 0.089 11.5 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 ArgK protein NB-ARC PF00931.17 ESL08325.1 - 0.11 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AMP-binding PF00501.23 ESL08326.1 - 2.8e-59 200.6 1.3 3.9e-57 193.5 0.6 2.9 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 ESL08326.1 - 1.2e-08 35.8 0.0 3.8e-08 34.1 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GOLGA2L5 PF15070.1 ESL08328.1 - 0.0041 15.6 0.6 0.0048 15.4 0.4 1.0 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 Maf PF02545.9 ESL08329.1 - 2.7e-22 78.8 0.0 3.2e-22 78.6 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein PNP_UDP_1 PF01048.15 ESL08329.1 - 0.041 12.8 0.0 0.076 11.9 0.0 1.5 1 1 0 1 1 1 0 Phosphorylase superfamily FAD_binding_3 PF01494.14 ESL08330.1 - 4.3e-10 39.1 0.0 1.6e-09 37.2 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain SE PF08491.5 ESL08330.1 - 0.00022 20.1 0.0 0.00064 18.6 0.0 1.9 1 0 0 1 1 1 1 Squalene epoxidase Pkinase PF00069.20 ESL08331.1 - 3.2e-38 131.3 0.0 2.1e-18 66.4 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08331.1 - 5e-09 35.6 0.0 2.5e-05 23.4 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase DUF3730 PF12530.3 ESL08332.1 - 0.054 13.4 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) Peptidase_M16 PF00675.15 ESL08334.1 - 7e-44 149.1 0.1 2.2e-43 147.5 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESL08334.1 - 3.9e-20 72.3 0.0 1.9e-18 66.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain Histone PF00125.19 ESL08335.1 - 1.7e-23 82.5 1.5 1.9e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL08335.1 - 7.1e-06 25.9 0.7 9.9e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESL08335.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated CENP-S PF15630.1 ESL08335.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore component CENP-S YihI PF04220.7 ESL08335.1 - 0.52 9.6 2.3 0.69 9.2 1.6 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) zf-DHHC PF01529.15 ESL08336.1 - 7.7e-27 93.7 0.1 7.7e-27 93.7 0.0 1.9 2 2 0 2 2 2 1 DHHC palmitoyltransferase 60KD_IMP PF02096.15 ESL08336.1 - 0.028 14.1 0.3 3.5 7.2 0.0 2.8 2 1 0 2 2 2 0 60Kd inner membrane protein Oxidored_q3 PF00499.15 ESL08336.1 - 0.04 13.6 1.3 0.04 13.6 0.9 3.2 4 1 0 4 4 4 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF912 PF06024.7 ESL08336.1 - 0.19 11.7 0.0 0.54 10.3 0.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Diphthamide_syn PF01866.12 ESL08337.1 - 5.4e-110 367.4 0.0 6.5e-110 367.1 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Ribosomal_S11 PF00411.14 ESL08339.1 - 3.2e-41 139.9 0.4 3.9e-41 139.6 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Acyltransferase PF01553.16 ESL08341.1 - 1.9e-19 69.4 0.0 3.6e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase CTP_transf_2 PF01467.21 ESL08342.1 - 0.014 15.4 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Cytidylyltransferase Beach PF02138.13 ESL08343.1 - 3.5e-89 298.8 0.0 6.4e-89 297.9 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 ESL08343.1 - 2e-11 43.6 0.0 4e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 ESL08343.1 - 4.5e-09 35.8 0.6 3.9e-05 23.3 0.2 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ATP_synt_H PF05493.8 ESL08344.1 - 2.4e-22 78.7 4.1 2.6e-22 78.6 2.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit H Claudin_2 PF13903.1 ESL08344.1 - 0.32 10.6 3.2 0.33 10.6 2.2 1.0 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4131 PF13567.1 ESL08344.1 - 1.6 8.0 5.2 1.7 8.0 3.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) UPF0564 PF10595.4 ESL08345.1 - 8.5e-07 28.2 1.9 1.4e-06 27.5 1.3 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 RF-1 PF00472.15 ESL08347.1 - 5.2e-14 52.0 0.3 1.3e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 RF-1 domain DUF3456 PF11938.3 ESL08349.1 - 7.2e-12 45.5 0.6 1.2e-11 44.8 0.4 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Potyvirid-P3 PF13608.1 ESL08349.1 - 0.0057 15.8 1.6 0.007 15.5 0.8 1.3 1 1 0 1 1 1 1 Protein P3 of Potyviral polyprotein Amidase PF01425.16 ESL08350.1 - 1.9e-62 211.5 0.0 1.3e-61 208.8 0.0 1.9 1 1 0 1 1 1 1 Amidase Transket_pyr PF02779.19 ESL08351.1 - 4.6e-60 202.1 0.0 7.5e-60 201.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESL08351.1 - 7.1e-48 162.8 0.0 1.1e-47 162.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Ribophorin_I PF04597.9 ESL08351.1 - 0.046 12.2 0.0 0.071 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribophorin I Choline_transpo PF04515.7 ESL08352.1 - 4.4e-69 232.7 52.3 4.4e-69 232.7 36.2 2.5 3 0 0 3 3 3 1 Plasma-membrane choline transporter CTDII PF01556.13 ESL08353.1 - 3.9e-24 84.3 0.0 6.1e-20 70.9 0.0 3.1 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESL08353.1 - 1.1e-11 44.6 16.5 1.7e-11 43.9 11.5 1.3 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.1 ESL08353.1 - 0.19 12.0 3.7 3.1 8.2 0.5 2.5 2 0 0 2 2 2 0 Cytochrome c3 zf-RING_5 PF14634.1 ESL08353.1 - 5 6.9 7.3 14 5.4 0.4 2.4 2 0 0 2 2 2 0 zinc-RING finger domain PRKCSH-like PF12999.2 ESL08355.1 - 2.1e-33 115.3 4.3 2.1e-33 115.3 3.0 1.4 1 1 0 1 1 1 1 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 ESL08355.1 - 2.9 7.8 18.3 1.9 8.4 2.0 2.7 2 1 0 2 2 2 0 Low-density lipoprotein receptor domain class A HSP70 PF00012.15 ESL08356.1 - 3.5e-60 203.5 5.2 4.5e-60 203.2 3.6 1.1 1 0 0 1 1 1 1 Hsp70 protein SPX PF03105.14 ESL08356.1 - 0.018 14.8 6.6 0.02 14.6 4.6 1.3 1 0 0 1 1 1 0 SPX domain PSD4 PF07631.6 ESL08356.1 - 0.047 14.0 0.6 0.092 13.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) CorA PF01544.13 ESL08356.1 - 0.3 10.0 2.1 0.42 9.5 1.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein WD40 PF00400.27 ESL08357.1 - 7.9e-47 155.5 13.3 1e-12 47.4 0.2 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESL08357.1 - 1e-08 35.1 0.0 0.00016 21.4 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A UDPGP PF01704.13 ESL08358.1 - 3.7e-05 22.3 0.0 6.2e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Atg14 PF10186.4 ESL08359.1 - 1.8e-05 23.8 1.2 2.5e-05 23.3 0.8 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 IFT20 PF14931.1 ESL08359.1 - 0.051 13.4 0.5 0.051 13.4 0.3 2.1 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 YlqD PF11068.3 ESL08359.1 - 0.18 11.8 6.0 1.5 8.8 0.1 2.6 1 1 1 2 2 2 0 YlqD protein DUF2968 PF11180.3 ESL08359.1 - 0.98 8.7 8.0 2.8 7.2 5.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) DivIC PF04977.10 ESL08359.1 - 1.9 8.0 7.5 5.3 6.5 0.2 2.6 2 1 0 2 2 2 0 Septum formation initiator Helicase_C_2 PF13307.1 ESL08360.1 - 7.5e-49 165.8 0.0 1.8e-48 164.6 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESL08360.1 - 4.7e-44 149.8 0.2 9.1e-44 148.9 0.1 1.5 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 ESL08360.1 - 2.8e-06 26.9 0.0 0.00016 21.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 ESL08360.1 - 3.6e-05 23.6 0.0 0.00034 20.4 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESL08360.1 - 0.00064 19.4 1.0 0.0041 16.8 0.2 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_11 PF13086.1 ESL08360.1 - 0.0071 15.9 0.0 0.024 14.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain SNF2_N PF00176.18 ESL08360.1 - 0.011 14.5 0.0 0.024 13.4 0.0 1.5 1 1 0 1 1 1 0 SNF2 family N-terminal domain Hydrolase_6 PF13344.1 ESL08360.1 - 0.081 12.8 0.0 23 4.9 0.0 2.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase tRNA-synt_1 PF00133.17 ESL08361.1 - 4.1e-110 368.5 0.0 4e-109 365.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 ESL08361.1 - 5.2e-08 32.3 0.0 0.0027 17.0 0.0 2.3 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 ESL08361.1 - 8.4e-08 31.2 0.1 1.7e-07 30.2 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (M) Pam16 PF03656.8 ESL08362.1 - 3.1e-05 23.7 0.0 4.2e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Pam16 Myb_DNA-binding PF00249.26 ESL08363.1 - 2.4e-05 24.2 0.9 3.7e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESL08363.1 - 0.0009 19.2 0.1 0.002 18.1 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Paf67 PF10255.4 ESL08364.1 - 3.5e-91 306.0 0.0 4.9e-91 305.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 ESL08364.1 - 0.041 13.8 0.1 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF569 PF04601.8 ESL08364.1 - 0.063 12.6 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF569) DFP PF04127.10 ESL08366.1 - 2.3e-21 76.2 0.0 6.4e-11 42.1 0.0 2.4 1 1 2 3 3 3 2 DNA / pantothenate metabolism flavoprotein Acetone_carb_G PF08882.6 ESL08366.1 - 0.068 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit Cullin_Nedd8 PF10557.4 ESL08367.1 - 2.5e-13 49.6 0.2 6.2e-13 48.3 0.2 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.17 ESL08367.1 - 5.8e-05 21.8 0.1 0.00019 20.1 0.0 1.7 2 0 0 2 2 2 1 Cullin family Kinesin PF00225.18 ESL08368.1 - 5.6e-56 189.6 0.6 9.1e-56 188.9 0.4 1.3 1 0 0 1 1 1 1 Kinesin motor domain FAD_binding_4 PF01565.18 ESL08369.1 - 2e-33 114.8 1.2 3.2e-33 114.1 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.14 ESL08369.1 - 6.9e-07 28.8 0.0 2.6e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain ATG16 PF08614.6 ESL08371.1 - 2.5e-05 24.2 11.6 0.00034 20.4 1.0 3.2 3 0 0 3 3 3 2 Autophagy protein 16 (ATG16) IncA PF04156.9 ESL08371.1 - 1.6 8.3 14.0 4.5 6.8 5.5 2.3 2 0 0 2 2 2 0 IncA protein DUF3552 PF12072.3 ESL08371.1 - 1.8 7.7 15.7 0.046 12.9 6.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) ADIP PF11559.3 ESL08371.1 - 5.6 6.8 11.9 19 5.1 0.3 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3367 PF11847.3 ESL08372.1 - 0.19 9.6 2.9 0.27 9.1 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3367) Clp1 PF06807.9 ESL08374.1 - 2.8e-32 112.0 0.0 3.8e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 ESL08374.1 - 2e-16 59.9 0.0 3.8e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESL08374.1 - 0.0089 15.9 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESL08374.1 - 0.015 15.3 0.0 0.039 13.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain DUF815 PF05673.8 ESL08374.1 - 0.047 12.6 0.0 0.076 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CbiA PF01656.18 ESL08374.1 - 0.11 11.9 0.2 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 ESL08374.1 - 0.11 13.3 0.0 0.27 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ESL08374.1 - 0.11 12.9 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 ESL08374.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.4 ESL08374.1 - 0.14 11.6 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.1 ESL08374.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain DnaJ PF00226.26 ESL08376.1 - 1.1e-08 34.6 0.0 2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DUF2271 PF10029.4 ESL08377.1 - 0.029 13.8 0.1 0.09 12.2 0.1 1.8 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) SR-25 PF10500.4 ESL08378.1 - 0.0047 16.4 16.4 0.0072 15.8 11.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein zf-U11-48K PF05253.7 ESL08378.1 - 0.0051 16.4 0.3 0.011 15.3 0.2 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger RRM_5 PF13893.1 ESL08378.1 - 0.05 13.4 0.0 0.32 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40_alt PF14077.1 ESL08380.1 - 0.67 9.6 0.0 0.67 9.6 0.0 3.4 5 0 0 5 5 5 0 Alternative WD40 repeat motif Laminin_II PF06009.7 ESL08380.1 - 8.4 6.1 32.0 0.16 11.7 4.1 4.5 2 1 3 5 5 5 0 Laminin Domain II DUF720 PF05302.6 ESL08380.1 - 8.8 6.1 10.0 15 5.3 4.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF720) DUF1491 PF07372.7 ESL08383.1 - 0.14 12.1 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) SAM_decarbox PF01536.11 ESL08384.1 - 8.5e-109 363.2 0.0 1e-108 362.9 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase SMN PF06003.7 ESL08385.1 - 0.69 8.9 3.7 1.1 8.2 2.6 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Mito_carr PF00153.22 ESL08386.1 - 3.6e-94 308.6 17.6 1e-21 76.4 0.0 6.4 5 2 1 6 6 6 6 Mitochondrial carrier protein MMR_HSR1 PF01926.18 ESL08387.1 - 1e-19 70.5 0.0 4.5e-19 68.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase YchF-GTPase_C PF06071.8 ESL08387.1 - 3.1e-16 58.9 0.0 6.8e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) FeoB_N PF02421.13 ESL08387.1 - 2.6e-08 33.3 0.1 5.7e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.16 ESL08387.1 - 0.0067 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 TGS domain DUF258 PF03193.11 ESL08387.1 - 0.021 14.0 0.0 0.054 12.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESL08387.1 - 0.062 14.1 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Carn_acyltransf PF00755.15 ESL08388.1 - 1e-05 23.8 0.0 9.5e-05 20.6 0.0 1.9 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase ERCC4 PF02732.10 ESL08389.1 - 1.7e-19 69.9 0.0 2.7e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain SAP PF02037.22 ESL08389.1 - 1.4e-05 24.4 0.2 3.1e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 SAP domain ETF_QO PF05187.8 ESL08390.1 - 4.4e-40 136.0 0.0 7.3e-40 135.3 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 ESL08390.1 - 1.7e-09 37.0 0.1 7.4e-05 21.8 0.9 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESL08390.1 - 2.1e-06 27.6 0.5 5.4e-06 26.3 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESL08390.1 - 1.5e-05 24.9 0.1 2.6e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESL08390.1 - 4.2e-05 22.5 0.7 0.00018 20.4 0.9 1.7 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 ESL08390.1 - 0.00011 21.3 0.1 0.00015 20.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.9 ESL08390.1 - 0.00019 20.0 0.2 0.00032 19.3 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_9 PF13454.1 ESL08390.1 - 0.00019 21.2 0.3 0.00051 19.8 0.1 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 ESL08390.1 - 0.00079 18.5 0.1 0.0015 17.6 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 ESL08390.1 - 0.003 16.6 0.1 0.0052 15.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 ESL08390.1 - 0.0038 17.3 0.0 0.0075 16.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESL08390.1 - 0.0084 15.2 0.5 0.013 14.6 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 ESL08390.1 - 0.01 14.5 0.2 0.022 13.3 0.1 1.5 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.17 ESL08390.1 - 0.049 12.4 0.2 0.078 11.8 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.22 ESL08390.1 - 0.075 13.4 0.0 0.83 10.1 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.2 ESL08390.1 - 0.089 13.1 0.9 0.22 11.9 0.6 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Arf PF00025.16 ESL08391.1 - 6.9e-06 25.4 0.1 3.9e-05 22.9 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESL08391.1 - 9.6e-06 24.5 0.1 0.0061 15.3 0.1 2.1 1 1 0 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.18 ESL08391.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL08391.1 - 3.1e-05 24.4 0.0 6.1e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Miro-like protein AAA_17 PF13207.1 ESL08391.1 - 0.00071 20.3 0.1 0.0015 19.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.7 ESL08391.1 - 0.0016 17.6 0.0 0.0036 16.4 0.0 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 ESL08391.1 - 0.0037 16.6 0.0 0.0064 15.9 0.0 1.5 1 1 0 1 1 1 1 Ras family Dynamin_N PF00350.18 ESL08391.1 - 0.0055 16.5 0.0 0.033 13.9 0.0 1.9 1 1 1 2 2 2 1 Dynamin family CobU PF02283.11 ESL08391.1 - 0.017 14.5 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase ABC_tran PF00005.22 ESL08391.1 - 0.024 14.9 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter Mg_chelatase PF01078.16 ESL08391.1 - 0.046 12.8 0.0 0.073 12.2 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 ESL08391.1 - 0.048 13.2 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 ESL08391.1 - 0.053 13.8 0.1 0.29 11.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain eIF2A PF08662.6 ESL08392.1 - 4.2e-19 69.0 0.1 1.1e-16 61.0 0.0 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A FTH PF01827.22 ESL08392.1 - 0.017 14.7 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 FTH domain NIT PF08376.5 ESL08392.1 - 0.022 14.2 1.8 0.1 12.0 0.7 2.0 2 0 0 2 2 2 0 Nitrate and nitrite sensing Lactonase PF10282.4 ESL08392.1 - 0.024 13.7 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller zf-CCHC PF00098.18 ESL08393.1 - 0.034 14.0 20.7 0.18 11.7 2.5 3.5 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.1 ESL08393.1 - 5.9 6.7 26.6 0.85 9.4 0.9 4.6 4 1 0 4 4 4 0 Zinc knuckle Rad60-SLD PF11976.3 ESL08396.1 - 3.9e-24 84.1 0.1 4.9e-24 83.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESL08396.1 - 6.8e-09 35.0 0.0 8.2e-09 34.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family RHH_1 PF01402.16 ESL08396.1 - 0.0021 17.8 0.0 0.0074 16.1 0.0 1.8 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family BPL_LplA_LipB PF03099.14 ESL08397.1 - 1.5e-07 31.4 0.1 6e-07 29.5 0.1 1.9 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DSPc PF00782.15 ESL08398.1 - 4.8e-08 32.6 0.0 6.2e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL08398.1 - 2.6e-06 26.9 0.0 6.8e-06 25.5 0.0 1.7 1 1 2 3 3 3 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 ESL08398.1 - 0.016 14.6 0.0 0.045 13.1 0.0 1.5 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) DnaJ PF00226.26 ESL08399.1 - 1.1e-18 66.6 0.0 2.3e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain zf-C3HC4_3 PF13920.1 ESL08399.1 - 0.001 18.6 10.8 0.002 17.7 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SRR PF07709.6 ESL08399.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.1 2 0 0 2 2 2 0 Seven Residue Repeat Peptidase_M24 PF00557.19 ESL08400.1 - 2.6e-43 148.0 0.2 3.8e-43 147.4 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3499 PF12005.3 ESL08400.1 - 0.47 10.6 3.1 0.59 10.3 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) DUF1903 PF08991.5 ESL08401.1 - 3.7e-08 33.4 4.7 1e-05 25.5 0.4 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1903) CHCH PF06747.8 ESL08401.1 - 9.3e-05 22.2 10.2 0.0094 15.8 3.2 2.6 2 1 1 3 3 3 3 CHCH domain CHORD PF04968.7 ESL08401.1 - 0.044 14.0 1.7 0.044 14.0 1.2 1.6 2 0 0 2 2 2 0 CHORD Cmc1 PF08583.5 ESL08401.1 - 2.2 8.1 14.3 2.6 7.8 5.1 3.1 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.12 ESL08401.1 - 9.4 6.3 12.4 4.6 7.3 1.9 2.4 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Ribonuclease_3 PF00636.21 ESL08403.1 - 0.027 14.9 0.0 0.099 13.0 0.0 1.9 1 1 0 1 1 1 0 Ribonuclease III domain GN3L_Grn1 PF08701.6 ESL08404.1 - 0.00017 21.4 11.8 0.00017 21.4 8.2 1.8 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase PVL_ORF50 PF07768.6 ESL08405.1 - 0.17 11.9 5.0 0.31 11.0 3.5 1.4 1 0 0 1 1 1 0 PVL ORF-50-like family Reo_sigmaC PF04582.7 ESL08406.1 - 1.4 8.0 19.0 1.8 7.6 0.1 5.8 3 1 4 7 7 7 0 Reovirus sigma C capsid protein Dynein_heavy PF03028.10 ESL08407.1 - 4.4e-35 120.8 0.0 5e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Erv26 PF04148.8 ESL08408.1 - 2e-21 76.3 12.3 8e-21 74.3 8.6 1.7 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 Raptor_N PF14538.1 ESL08409.1 - 1.4e-53 180.8 0.0 3.3e-53 179.6 0.0 1.7 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.17 ESL08409.1 - 7.7e-06 25.5 0.6 0.18 11.9 0.1 3.1 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.1 ESL08409.1 - 0.00052 20.2 0.0 0.021 15.1 0.0 3.1 4 1 1 5 5 5 2 HEAT repeats Cnd1 PF12717.2 ESL08409.1 - 0.11 12.3 0.2 5.3 6.8 0.0 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 FHA PF00498.21 ESL08410.1 - 8.4e-08 32.2 0.0 2.3e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 FHA domain IF4E PF01652.13 ESL08411.1 - 1.1e-39 135.6 0.1 1.3e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E FOP_dimer PF09398.5 ESL08412.1 - 4.6e-09 36.1 0.0 8.5e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 FOP N terminal dimerisation domain UAA PF08449.6 ESL08413.1 - 1.7e-38 132.2 20.2 4.3e-27 94.8 4.6 2.0 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.15 ESL08413.1 - 3.3e-07 30.3 6.2 3.3e-07 30.3 4.3 3.2 2 2 1 3 3 3 1 EamA-like transporter family TPT PF03151.11 ESL08413.1 - 4.6e-06 26.3 7.5 4.6e-06 26.3 5.2 2.8 2 2 1 3 3 3 1 Triose-phosphate Transporter family DUF606 PF04657.8 ESL08413.1 - 0.012 15.7 1.2 0.012 15.7 0.8 3.4 4 1 0 4 4 4 0 Protein of unknown function, DUF606 DUF308 PF03729.8 ESL08413.1 - 3.3 7.7 14.4 0.22 11.5 0.3 3.8 4 0 0 4 4 4 0 Short repeat of unknown function (DUF308) DUF3185 PF11381.3 ESL08413.1 - 3.9 7.3 7.5 3.7 7.3 0.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) Phytochelatin PF05023.9 ESL08414.1 - 1.1e-06 27.8 0.1 0.00015 20.8 0.0 2.3 2 0 0 2 2 2 2 Phytochelatin synthase TFIIB PF00382.14 ESL08416.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat IMS PF00817.15 ESL08417.1 - 1.7e-09 37.6 0.0 1.6e-08 34.4 0.0 2.2 2 0 0 2 2 2 1 impB/mucB/samB family IMS_HHH PF11798.3 ESL08417.1 - 0.0053 16.7 0.0 0.015 15.3 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif IMS_C PF11799.3 ESL08417.1 - 0.022 14.6 0.9 0.069 13.0 0.2 2.0 2 0 0 2 2 2 0 impB/mucB/samB family C-terminal domain DUF2762 PF10960.3 ESL08417.1 - 0.15 11.8 0.6 1.3 8.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2762) DUF3505 PF12013.3 ESL08418.1 - 0.0074 16.5 0.6 0.01 16.0 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3505) Actin PF00022.14 ESL08419.1 - 2.3e-41 141.5 0.0 2.7e-41 141.3 0.0 1.0 1 0 0 1 1 1 1 Actin UQ_con PF00179.21 ESL08422.1 - 1.1e-22 80.0 0.0 1.5e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LSM PF01423.17 ESL08423.1 - 4.6e-12 45.3 0.0 6.2e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESL08423.1 - 0.0023 17.7 0.1 0.0079 16.0 0.1 1.8 1 1 0 1 1 1 1 Ataxin 2 SM domain LRR_4 PF12799.2 ESL08424.1 - 0.00031 20.2 0.5 0.027 14.0 0.1 3.1 2 1 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESL08424.1 - 0.0007 19.2 0.1 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat Kinesin PF00225.18 ESL08425.1 - 2.1e-17 62.8 0.0 2.8e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 ESL08425.1 - 0.081 13.0 0.2 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain ETF_alpha PF00766.14 ESL08426.1 - 1.6e-34 117.3 0.1 3.3e-34 116.3 0.1 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.16 ESL08426.1 - 8.2e-32 110.1 3.0 1.7e-31 109.1 2.1 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain GHMP_kinases_N PF00288.21 ESL08427.1 - 2.8e-13 49.7 0.2 6.3e-13 48.5 0.2 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 ESL08427.1 - 1.7e-09 37.7 0.2 6.8e-09 35.8 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases C terminal PQ-loop PF04193.9 ESL08429.1 - 3.2e-21 74.6 0.2 3.2e-16 58.5 0.0 2.5 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.11 ESL08429.1 - 0.21 11.4 6.6 1.7 8.5 1.3 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Cyclin_N PF00134.18 ESL08430.1 - 1.6e-23 82.6 0.1 3.7e-23 81.4 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESL08430.1 - 0.1 12.5 0.1 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Cyclin, C-terminal domain CHAP PF05257.11 ESL08431.1 - 3e-14 52.7 0.0 4.2e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 CHAP domain WD40 PF00400.27 ESL08432.1 - 3.2e-07 29.9 2.0 0.0012 18.6 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat GlcNAc PF11397.3 ESL08433.1 - 1.7e-22 80.0 0.0 8.9e-13 48.0 0.0 3.2 2 1 0 2 2 2 2 Glycosyltransferase (GlcNAc) DUF1126 PF06565.7 ESL08434.1 - 1.9e-34 116.8 0.0 3.5e-10 39.1 0.0 3.6 3 0 0 3 3 3 3 Repeat of unknown function (DUF1126) EF-hand_8 PF13833.1 ESL08434.1 - 5.1e-07 29.2 1.0 0.0011 18.5 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 ESL08434.1 - 1.9e-05 24.6 1.9 0.00032 20.7 0.2 2.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL08434.1 - 0.00036 19.6 0.2 0.0025 17.0 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 ESL08434.1 - 0.037 13.9 0.3 1.4 9.0 0.1 3.2 2 0 0 2 2 2 0 EF-hand domain DUF4460 PF14687.1 ESL08434.1 - 0.074 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4460) EF-hand_5 PF13202.1 ESL08434.1 - 0.14 11.5 3.2 0.15 11.4 0.1 2.7 3 0 0 3 3 3 0 EF hand DUF2730 PF10805.3 ESL08435.1 - 0.0013 18.4 13.8 0.019 14.7 0.7 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF2730) Spc7 PF08317.6 ESL08435.1 - 0.13 10.8 21.0 0.011 14.3 10.7 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.7 ESL08435.1 - 0.57 10.4 4.2 20 5.5 0.4 3.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.6 ESL08436.1 - 0.00048 20.0 22.3 0.03 14.1 0.1 2.6 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) DUF972 PF06156.8 ESL08436.1 - 0.0092 16.3 19.2 0.011 16.1 3.1 4.7 3 1 2 5 5 5 1 Protein of unknown function (DUF972) GAS PF13851.1 ESL08436.1 - 0.014 14.6 18.7 0.041 13.0 5.1 3.4 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding CDC37_N PF03234.9 ESL08436.1 - 0.032 14.5 10.8 0.084 13.1 7.5 1.6 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding CCDC155 PF14662.1 ESL08436.1 - 0.058 12.9 24.1 0.021 14.4 12.5 3.0 3 1 0 3 3 3 0 Coiled-coil region of CCDC155 DUF4200 PF13863.1 ESL08436.1 - 0.059 13.3 20.1 0.038 13.9 9.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) HALZ PF02183.13 ESL08436.1 - 0.067 12.9 17.7 24 4.7 5.5 4.9 3 1 1 4 4 4 0 Homeobox associated leucine zipper TSC22 PF01166.13 ESL08436.1 - 0.077 12.9 12.4 5 7.1 0.0 4.4 4 1 0 4 4 4 0 TSC-22/dip/bun family DUF904 PF06005.7 ESL08436.1 - 0.079 13.2 22.1 0.12 12.7 6.6 3.9 4 0 0 4 4 3 0 Protein of unknown function (DUF904) Phage_P2_GpE PF06528.7 ESL08436.1 - 0.14 11.5 0.1 0.28 10.6 0.1 1.5 1 0 0 1 1 1 0 Phage P2 GpE HAUS-augmin3 PF14932.1 ESL08436.1 - 0.44 9.6 13.0 1.1 8.4 9.0 1.6 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 TMF_DNA_bd PF12329.3 ESL08436.1 - 0.49 10.2 17.7 0.3 10.9 6.2 3.7 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESL08436.1 - 0.61 9.6 18.4 12 5.4 4.0 4.9 3 1 1 5 5 5 0 Septum formation initiator Baculo_p24 PF05073.7 ESL08436.1 - 5.4 6.5 6.3 1.9 7.9 0.0 2.5 2 1 0 2 2 2 0 Baculovirus P24 capsid protein DivIVA PF05103.8 ESL08436.1 - 8.1 6.5 23.9 2.4 8.2 1.6 3.6 2 2 1 3 3 3 0 DivIVA protein Phlebovirus_NSM PF07246.6 ESL08436.1 - 8.5 5.4 11.1 33 3.5 0.0 2.8 2 1 0 2 2 2 0 Phlebovirus nonstructural protein NS-M DUF3250 PF11618.3 ESL08437.1 - 2.7e-27 95.0 0.5 2.7e-27 95.0 0.3 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF3250) PPR_2 PF13041.1 ESL08438.1 - 1.3e-06 28.2 3.3 0.35 10.8 0.0 4.6 5 1 1 6 6 6 3 PPR repeat family PPR PF01535.15 ESL08438.1 - 0.00093 19.0 0.3 56 4.0 0.0 4.9 5 0 0 5 5 5 0 PPR repeat TPR_11 PF13414.1 ESL08438.1 - 0.0018 17.8 2.8 0.027 14.0 1.6 2.7 1 1 1 2 2 2 1 TPR repeat TPR_14 PF13428.1 ESL08438.1 - 0.062 13.9 0.7 13 6.7 0.3 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL08438.1 - 0.067 13.5 0.2 2.4 8.5 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESL08438.1 - 0.68 10.6 4.3 3.1 8.5 0.6 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.27 ESL08439.1 - 7.6e-10 38.2 6.8 5.2e-06 26.1 0.2 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Atg14 PF10186.4 ESL08439.1 - 0.0018 17.3 3.8 0.0032 16.4 2.6 1.4 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 FadA PF09403.5 ESL08439.1 - 0.51 10.3 9.7 1.1 9.3 6.7 1.4 1 0 0 1 1 1 0 Adhesion protein FadA PQQ_3 PF13570.1 ESL08439.1 - 1 9.7 4.5 1.8 8.9 0.3 3.5 4 1 0 4 4 4 0 PQQ-like domain TPR_11 PF13414.1 ESL08440.1 - 3.1e-22 77.9 18.1 6.4e-08 32.1 0.4 7.2 4 1 4 8 8 8 5 TPR repeat TPR_19 PF14559.1 ESL08440.1 - 1.1e-19 70.5 1.4 1.9e-07 31.3 0.0 6.2 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08440.1 - 8.5e-19 66.3 9.8 3.2e-05 23.3 0.4 8.7 9 0 0 9 9 8 3 Tetratricopeptide repeat Apc3 PF12895.2 ESL08440.1 - 5.4e-16 58.4 16.7 2.1e-09 37.4 0.5 6.9 3 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESL08440.1 - 8e-16 57.1 8.6 0.0016 18.8 0.0 7.5 4 2 3 7 7 6 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08440.1 - 9.5e-16 56.3 19.2 1.5e-05 24.5 0.3 9.1 9 1 0 9 9 8 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESL08440.1 - 2.4e-15 55.3 1.7 0.0004 20.3 0.0 8.8 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL08440.1 - 7.6e-14 51.9 20.7 7.6e-05 23.2 0.7 6.4 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08440.1 - 8.7e-13 48.0 22.1 0.0037 17.1 0.6 7.1 5 1 4 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08440.1 - 8.3e-12 43.9 5.0 0.0017 17.9 0.1 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL08440.1 - 3.6e-07 29.9 8.3 1.1e-05 25.2 0.4 4.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08440.1 - 2.7e-05 23.6 5.2 0.33 10.8 0.0 6.0 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_4 PF07721.9 ESL08440.1 - 3e-05 24.0 15.2 0.019 15.3 1.0 5.5 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESL08440.1 - 3.7e-05 22.9 1.0 0.0025 16.9 0.2 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08440.1 - 7.1e-05 23.0 10.9 5.6 7.6 0.1 7.5 9 0 0 9 9 6 1 Tetratricopeptide repeat BTAD PF03704.12 ESL08440.1 - 0.00028 21.2 16.8 0.0029 17.9 1.6 4.3 3 1 0 3 3 3 2 Bacterial transcriptional activator domain Coatomer_E PF04733.9 ESL08440.1 - 0.00095 18.4 0.0 0.092 11.9 0.0 2.8 3 1 0 3 3 3 1 Coatomer epsilon subunit TPR_20 PF14561.1 ESL08440.1 - 0.00096 19.2 0.2 0.017 15.2 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.3 ESL08440.1 - 0.0011 17.8 0.6 0.068 11.9 0.0 2.3 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 PPR PF01535.15 ESL08440.1 - 0.0084 16.0 0.3 1.5 8.9 0.0 4.6 5 0 0 5 5 4 1 PPR repeat PPR_3 PF13812.1 ESL08440.1 - 0.013 15.7 0.5 0.17 12.2 0.1 3.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain TPR_3 PF07720.7 ESL08440.1 - 0.055 13.2 0.2 1.5 8.6 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL08440.1 - 0.16 11.9 15.1 0.67 9.9 0.1 5.7 5 1 1 6 6 5 0 Tetratricopeptide repeat Synaptobrevin PF00957.16 ESL08441.1 - 1.3e-26 92.0 0.4 1.3e-26 92.0 0.3 1.5 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.1 ESL08441.1 - 0.00066 19.1 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain EF-hand_7 PF13499.1 ESL08443.1 - 1.8e-08 34.4 2.5 6.1e-06 26.2 0.5 2.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL08443.1 - 3.1e-08 32.8 0.1 0.00095 18.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 ESL08443.1 - 6.4e-08 31.3 0.1 0.0059 15.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 ESL08443.1 - 4.1e-06 25.8 0.1 0.066 12.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 ESL08443.1 - 1e-05 25.0 4.9 0.0014 18.2 0.2 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 ESL08443.1 - 0.016 15.1 0.2 0.79 9.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain Dockerin_1 PF00404.13 ESL08443.1 - 0.039 13.6 6.8 0.089 12.5 0.1 2.5 2 0 0 2 2 2 0 Dockerin type I repeat Metallophos PF00149.23 ESL08444.1 - 2e-33 115.4 1.3 2.6e-33 115.1 0.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Tyr_Deacylase PF02580.11 ESL08445.1 - 8.5e-40 136.0 0.0 9.6e-40 135.9 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Vps54 PF07928.7 ESL08446.1 - 3.7e-37 127.4 0.0 7.8e-37 126.4 0.0 1.6 1 0 0 1 1 1 1 Vps54-like protein DUF2450 PF10475.4 ESL08446.1 - 0.084 11.7 0.1 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) COG2 PF06148.6 ESL08446.1 - 0.099 12.5 0.1 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 PEX11 PF05648.9 ESL08447.1 - 0.0023 17.2 0.3 0.019 14.2 0.0 2.1 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) Peptidase_S24 PF00717.18 ESL08448.1 - 3.3e-08 33.0 0.0 4.7e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like MIP PF00230.15 ESL08449.1 - 2.5e-26 92.5 16.4 1.7e-25 89.8 11.4 1.9 1 1 0 1 1 1 1 Major intrinsic protein Peptidase_U4 PF03419.8 ESL08449.1 - 0.91 8.5 7.4 1.6 7.7 5.1 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Abhydrolase_3 PF07859.8 ESL08450.1 - 5.8e-12 45.6 0.1 1.1e-11 44.7 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESL08450.1 - 1.5e-11 44.2 0.0 2.8e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 ESL08450.1 - 1e-10 40.9 0.1 1.8e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.2 ESL08450.1 - 4.4e-10 39.8 0.2 9.4e-10 38.7 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESL08450.1 - 0.0013 18.0 0.1 0.61 9.2 0.3 2.9 2 1 0 2 2 2 2 Prolyl oligopeptidase family GerA PF03323.8 ESL08450.1 - 0.4 8.7 1.6 0.58 8.2 1.1 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein DnaJ PF00226.26 ESL08451.1 - 2e-19 69.0 0.0 3e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain TPR_11 PF13414.1 ESL08452.1 - 8.7e-05 22.0 1.9 2 8.1 0.0 3.9 3 1 1 4 4 4 2 TPR repeat TPR_2 PF07719.12 ESL08452.1 - 0.00012 21.7 6.6 0.0058 16.4 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08452.1 - 0.00021 20.8 0.4 0.011 15.4 0.1 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08452.1 - 0.00056 19.4 2.9 0.035 13.7 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL08452.1 - 0.00095 19.4 1.2 0.7 10.2 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL08452.1 - 0.0034 17.4 0.1 0.67 10.3 0.0 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat SPO22 PF08631.5 ESL08452.1 - 0.0042 16.2 1.0 0.073 12.1 0.1 2.4 2 1 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like TPR_16 PF13432.1 ESL08452.1 - 0.0043 17.6 0.9 0.35 11.6 0.0 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL08452.1 - 0.013 16.0 2.0 13 6.7 0.0 4.1 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08452.1 - 0.014 15.3 0.6 1.9 8.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESL08452.1 - 0.037 14.2 0.9 0.088 13.0 0.1 2.0 2 1 0 2 2 2 0 Alkyl sulfatase dimerisation Sel1 PF08238.7 ESL08452.1 - 0.072 13.7 3.5 2.9 8.6 0.1 4.0 3 2 0 3 3 3 0 Sel1 repeat ATP-grasp_4 PF13535.1 ESL08454.1 - 1.1e-21 77.4 0.1 2.5e-21 76.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESL08454.1 - 5.3e-05 22.1 0.0 0.047 12.4 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 ESL08454.1 - 0.017 14.9 0.0 0.052 13.4 0.0 1.8 1 1 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.14 ESL08454.1 - 0.026 14.1 0.2 0.25 10.8 0.0 2.5 2 1 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Snf7 PF03357.16 ESL08455.1 - 1.2e-22 80.0 16.8 1.2e-22 80.0 11.7 1.3 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.9 ESL08455.1 - 0.088 12.2 4.0 0.59 9.5 2.7 2.0 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF445 PF04286.7 ESL08455.1 - 0.18 11.2 4.2 0.24 10.8 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Mer2 PF09074.5 ESL08455.1 - 3 7.7 12.3 2.5 7.9 7.3 1.7 1 1 1 2 2 2 0 Mer2 NPL4 PF05021.10 ESL08456.1 - 3.1e-27 95.5 0.0 4.9e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 NPL4 family Ribosomal_L32p PF01783.18 ESL08456.1 - 0.07 13.3 1.4 0.14 12.3 1.0 1.4 1 0 0 1 1 1 0 Ribosomal L32p protein family RNase_PH PF01138.16 ESL08458.1 - 1.3e-16 61.0 1.3 1.7e-16 60.7 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 AAA_13 PF13166.1 ESL08461.1 - 0.0014 17.2 2.7 0.0018 16.8 1.9 1.1 1 0 0 1 1 1 1 AAA domain DUF2620 PF10941.3 ESL08461.1 - 0.075 13.0 0.0 0.74 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF2620 NAD_binding_1 PF00175.16 ESL08461.1 - 0.5 10.9 3.8 1.2 9.7 0.4 2.6 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Tup_N PF08581.5 ESL08461.1 - 0.88 9.7 11.4 1.4 9.1 0.4 2.9 2 1 0 2 2 2 0 Tup N-terminal Gly-rich_Ago1 PF12764.2 ESL08462.1 - 0.0081 16.7 0.5 0.015 15.8 0.3 1.4 1 0 0 1 1 1 1 Glycine-rich region of argonaut GCOM2 PF15328.1 ESL08462.1 - 0.043 13.5 2.2 0.17 11.6 1.6 2.0 1 1 0 1 1 1 0 Putative GRINL1B complex locus protein 2 DUF1925 PF09094.6 ESL08462.1 - 0.23 11.4 1.2 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1925) Calc_CGRP_IAPP PF00214.14 ESL08462.1 - 7.9 6.5 8.2 12 5.9 2.0 2.3 1 1 1 2 2 2 0 Calcitonin / CGRP / IAPP family OTU PF02338.14 ESL08463.1 - 5.4e-10 39.9 0.0 7.7e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Hist_deacetyl PF00850.14 ESL08464.1 - 3.3e-78 263.1 0.5 1.3e-46 159.2 0.2 2.1 2 0 0 2 2 2 2 Histone deacetylase domain RAP1 PF07218.6 ESL08464.1 - 0.025 12.6 3.7 0.036 12.1 2.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3306 PF11748.3 ESL08464.1 - 0.11 13.1 1.9 0.28 11.8 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF4653 PF15546.1 ESL08464.1 - 1.5 8.0 6.0 2.4 7.3 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) RRM_1 PF00076.17 ESL08466.1 - 2.2e-11 43.2 0.1 3.3e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL08466.1 - 1.9e-09 37.3 0.1 3.3e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08466.1 - 7.2e-05 22.5 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1014 PF06244.7 ESL08467.1 - 3.9e-10 39.9 18.6 3.9e-10 39.9 12.9 3.3 2 1 0 2 2 2 1 Protein of unknown function (DUF1014) TFIIA_gamma_N PF02268.11 ESL08468.1 - 0.1 12.2 0.1 0.27 10.8 0.1 1.7 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain DUF3762 PF12591.3 ESL08468.1 - 0.12 12.4 0.1 0.37 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3762) WW PF00397.21 ESL08470.1 - 1.2e-33 114.5 23.6 1.8e-11 43.6 1.4 5.2 5 0 0 5 5 5 4 WW domain SoxD PF04267.7 ESL08470.1 - 0.03 14.1 0.0 3.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Sarcosine oxidase, delta subunit family PUF PF00806.14 ESL08471.1 - 2.9e-21 73.6 3.3 7.1e-05 22.0 0.0 5.6 6 0 0 6 6 6 4 Pumilio-family RNA binding repeat Proteasome PF00227.21 ESL08472.1 - 1.4e-31 109.2 0.0 1.6e-31 109.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit MMR_HSR1 PF01926.18 ESL08473.1 - 5.5e-05 23.1 0.0 8.9e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESL08473.1 - 0.0026 17.7 0.0 0.005 16.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain Miro PF08477.8 ESL08473.1 - 0.04 14.4 0.0 0.073 13.5 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein FeoB_N PF02421.13 ESL08473.1 - 0.079 12.2 0.1 0.15 11.2 0.0 1.5 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF258 PF03193.11 ESL08473.1 - 0.083 12.0 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 ESL08473.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Methyltransf_8 PF05148.10 ESL08474.1 - 6.6e-50 169.7 0.0 8.4e-50 169.4 0.0 1.1 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 ESL08474.1 - 8.6e-08 32.5 0.0 2.1e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL08474.1 - 0.001 18.7 0.0 0.0019 17.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESL08474.1 - 0.0017 17.4 0.0 0.0028 16.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 ESL08474.1 - 0.021 14.3 0.1 0.98 8.9 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain TPP_enzyme_N PF02776.13 ESL08475.1 - 2e-21 76.2 0.1 3.2e-20 72.2 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 ESL08475.1 - 4e-13 49.2 1.2 1.7e-11 43.9 0.8 2.8 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PHD PF00628.24 ESL08476.1 - 0.022 14.4 8.7 0.042 13.5 6.0 1.5 1 0 0 1 1 1 0 PHD-finger Spc7 PF08317.6 ESL08476.1 - 0.039 12.6 0.0 0.059 12.0 0.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Dynamin_N PF00350.18 ESL08477.1 - 2.2e-19 69.8 0.0 1.2e-18 67.5 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESL08477.1 - 5.3e-10 39.2 0.0 1.1e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL08477.1 - 0.018 14.5 0.0 0.088 12.2 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESL08477.1 - 0.044 12.9 0.0 0.48 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 EFhand_Ca_insen PF08726.5 ESL08477.1 - 7.4 6.6 7.8 19 5.3 0.5 3.1 2 0 0 2 2 2 0 Ca2+ insensitive EF hand PGAP1 PF07819.8 ESL08478.1 - 1.2e-09 38.1 0.0 0.00039 20.0 0.0 2.4 2 0 0 2 2 2 2 PGAP1-like protein Abhydrolase_6 PF12697.2 ESL08478.1 - 0.00025 20.9 0.2 0.0011 18.8 0.1 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF4489 PF14879.1 ESL08478.1 - 0.0049 16.5 0.1 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4489) Abhydrolase_5 PF12695.2 ESL08478.1 - 0.12 12.1 0.0 0.45 10.2 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Sec7 PF01369.15 ESL08479.1 - 6.5e-39 133.5 0.0 1.3e-38 132.6 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESL08479.1 - 0.034 13.5 0.0 0.14 11.6 0.0 2.0 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal WD40 PF00400.27 ESL08480.1 - 9.8e-15 53.8 1.1 5.4e-06 26.0 0.0 5.2 5 1 0 5 5 5 2 WD domain, G-beta repeat SMK-1 PF04802.10 ESL08481.1 - 0.00079 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Rtf2 PF04641.7 ESL08482.1 - 4e-23 81.9 0.1 6.1e-23 81.3 0.1 1.4 1 1 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.3 ESL08482.1 - 0.00017 21.0 0.0 0.00066 19.1 0.0 2.0 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.1 ESL08482.1 - 0.032 13.9 2.4 0.13 11.9 1.7 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL08482.1 - 0.14 12.0 2.9 3.8 7.4 1.2 2.6 2 1 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.1 ESL08482.1 - 3.3 7.8 7.1 6.3 6.9 2.7 2.9 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) EF-hand_6 PF13405.1 ESL08483.1 - 3.4e-17 60.7 0.6 6.1e-06 25.6 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 ESL08483.1 - 1e-16 58.8 0.2 1.5e-06 27.0 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 ESL08483.1 - 4.8e-16 58.6 0.1 1.3e-07 31.5 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 ESL08483.1 - 6.9e-13 47.2 0.3 2.3e-05 23.4 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 ESL08483.1 - 1.4e-11 43.8 1.7 0.001 18.5 0.0 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 ESL08483.1 - 0.0082 16.0 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain Toprim_2 PF13155.1 ESL08483.1 - 0.051 13.8 0.0 3.6 7.9 0.0 2.7 1 1 1 2 2 2 0 Toprim-like DUF2680 PF10925.3 ESL08483.1 - 0.053 13.4 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) SPARC_Ca_bdg PF10591.4 ESL08483.1 - 0.081 12.9 0.0 3.9 7.5 0.0 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region ALF PF03752.8 ESL08483.1 - 0.38 10.6 4.2 0.56 10.1 0.2 2.7 3 0 0 3 3 3 0 Short repeats of unknown function Complex1_LYR PF05347.10 ESL08485.1 - 3.7e-11 42.6 0.2 5.5e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESL08485.1 - 2.6e-09 37.1 0.1 4.1e-09 36.5 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Cnl2_NKP2 PF09447.5 ESL08486.1 - 0.076 12.7 0.1 18 5.1 0.0 2.5 2 0 0 2 2 2 0 Cnl2/NKP2 family protein DUF2312 PF10073.4 ESL08487.1 - 0.097 12.0 0.5 0.18 11.2 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Peptidase_M4_C PF02868.10 ESL08488.1 - 0.02 14.6 1.1 0.039 13.6 0.1 1.9 2 0 0 2 2 2 0 Thermolysin metallopeptidase, alpha-helical domain Sybindin PF04099.7 ESL08492.1 - 4.3e-21 75.1 0.0 5e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 ESL08492.1 - 2.1e-09 37.3 0.0 2.4e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region NTF2 PF02136.15 ESL08493.1 - 5.5e-15 55.7 0.0 6.3e-15 55.5 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain PspB PF06667.7 ESL08494.1 - 0.016 15.1 0.7 0.043 13.7 0.5 1.7 1 0 0 1 1 1 0 Phage shock protein B FmdA_AmdA PF03069.10 ESL08494.1 - 0.017 13.8 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 Acetamidase/Formamidase family GvpG PF05120.7 ESL08495.1 - 0.058 13.1 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 Gas vesicle protein G TNFR_c6 PF00020.13 ESL08496.1 - 1.4 9.0 4.4 2.5 8.2 0.1 2.4 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region CHCH PF06747.8 ESL08496.1 - 1.5 8.8 12.9 0.71 9.8 0.2 3.8 4 0 0 4 4 4 0 CHCH domain Pkinase PF00069.20 ESL08497.1 - 7.6e-59 198.9 0.0 8.8e-59 198.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08497.1 - 2.4e-36 125.1 0.0 2.9e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08497.1 - 4.2e-06 25.9 0.0 5.3e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESL08497.1 - 0.0065 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESL08497.1 - 0.0086 15.1 0.1 0.016 14.2 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL08497.1 - 0.01 15.5 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESL08497.1 - 0.016 14.0 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Glyco_hydro_6 PF01341.12 ESL08497.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 6 RIO1 PF01163.17 ESL08497.1 - 0.13 11.5 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family polyprenyl_synt PF00348.12 ESL08498.1 - 5.6e-42 143.3 0.0 8.4e-42 142.8 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase CrtC PF07143.6 ESL08498.1 - 2.2e-28 99.4 0.1 2e-27 96.3 0.1 2.0 1 1 0 1 1 1 1 Hydroxyneurosporene synthase (CrtC) RabGAP-TBC PF00566.13 ESL08500.1 - 6e-21 74.9 0.0 8.1e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PAM2 PF07145.10 ESL08501.1 - 0.036 13.5 0.0 0.068 12.6 0.0 1.5 1 0 0 1 1 1 0 Ataxin-2 C-terminal region WD40 PF00400.27 ESL08502.1 - 1.6e-28 97.4 5.4 1.9e-08 33.8 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat zf-Apc11 PF12861.2 ESL08503.1 - 3.5e-33 113.3 13.7 3.8e-33 113.1 9.5 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESL08503.1 - 5.2e-28 96.9 14.7 5.8e-28 96.8 10.2 1.0 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESL08503.1 - 2.2e-06 27.4 23.2 3.6e-06 26.6 14.8 2.5 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.1 ESL08503.1 - 0.0024 17.7 4.2 0.0024 17.7 2.9 2.6 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 ESL08503.1 - 0.0026 17.4 22.2 0.095 12.4 14.7 2.4 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL08503.1 - 0.0045 16.6 20.0 0.0095 15.5 13.0 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL08503.1 - 0.0099 15.8 18.1 0.26 11.3 12.0 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL08503.1 - 0.13 11.9 20.5 8.3 6.1 12.7 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pellino PF04710.9 ESL08503.1 - 0.17 10.4 4.7 0.59 8.7 0.7 2.0 1 1 1 2 2 2 0 Pellino zf-Nse PF11789.3 ESL08503.1 - 0.25 10.8 9.9 0.42 10.1 6.9 1.4 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESL08503.1 - 1.7 8.4 10.6 2.4 7.9 6.5 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C2H2_6 PF13912.1 ESL08503.1 - 4.4 7.3 8.2 0.54 10.2 0.7 2.7 1 1 1 2 2 2 0 C2H2-type zinc finger zf-UDP PF14569.1 ESL08503.1 - 7.6 6.3 12.5 7.5e+02 -0.1 9.0 2.3 1 1 1 2 2 2 0 Zinc-binding RING-finger Pro_isomerase PF00160.16 ESL08504.1 - 6.3e-44 149.9 0.1 9.7e-44 149.3 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 ESL08504.1 - 3.2e-22 77.9 11.1 2.5e-13 49.4 0.4 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESL08504.1 - 3e-18 64.2 1.0 4.4e-06 26.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08504.1 - 1.5e-15 56.0 1.6 3.2e-07 29.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08504.1 - 8.3e-11 41.6 6.4 2.3e-06 27.4 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL08504.1 - 3e-09 36.0 0.6 0.0065 16.1 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL08504.1 - 1.9e-06 28.3 0.7 1.6e-05 25.4 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL08504.1 - 6.1e-06 26.4 0.1 0.18 12.5 0.1 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL08504.1 - 6.4e-06 26.2 0.4 0.62 10.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESL08504.1 - 7.2e-06 25.8 3.3 0.0025 17.8 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL08504.1 - 7.2e-05 22.8 4.0 0.016 15.3 1.4 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESL08504.1 - 0.00014 21.3 2.7 2.5 8.0 0.0 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat DUF3856 PF12968.2 ESL08504.1 - 0.00056 19.7 3.1 0.00094 19.0 0.6 2.3 2 1 0 2 2 1 1 Domain of Unknown Function (DUF3856) TPR_19 PF14559.1 ESL08504.1 - 0.00089 19.5 1.7 0.0063 16.8 0.4 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Coatomer_E PF04733.9 ESL08504.1 - 0.02 14.0 1.0 0.034 13.3 0.7 1.3 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_9 PF13371.1 ESL08504.1 - 0.042 13.7 0.0 0.22 11.4 0.0 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat She2p PF11435.3 ESL08504.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA binding protein She2p BAR PF03114.13 ESL08504.1 - 0.13 11.7 2.3 0.27 10.6 1.6 1.4 1 1 0 1 1 1 0 BAR domain Fis1_TPR_C PF14853.1 ESL08504.1 - 0.21 11.5 0.7 2.2 8.2 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat B3_4 PF03483.12 ESL08505.1 - 9.9e-17 60.9 0.0 1.9e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 ESL08505.1 - 6.9e-16 57.8 0.0 8.5e-15 54.3 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase B5 domain DnaB_bind PF10410.4 ESL08505.1 - 0.12 12.4 0.0 4.6 7.3 0.0 2.4 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase Enkurin PF13864.1 ESL08507.1 - 0.35 11.1 4.0 0.18 11.9 0.7 2.0 2 0 0 2 2 2 0 Calmodulin-binding Skp1 PF01466.14 ESL08509.1 - 0.019 14.9 0.2 0.019 14.9 0.2 2.5 2 1 0 2 2 2 0 Skp1 family, dimerisation domain SET PF00856.23 ESL08511.1 - 9.3e-13 48.8 0.0 1.1e-11 45.3 0.0 2.6 2 1 0 2 2 2 1 SET domain DEAD PF00270.24 ESL08513.1 - 3.1e-33 114.6 0.0 1.3e-32 112.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL08513.1 - 5e-26 90.3 0.1 1.4e-25 88.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 ESL08513.1 - 0.048 13.6 0.1 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 Helicase C-terminal domain ADH_N PF08240.7 ESL08514.1 - 4.2e-14 52.2 1.0 2.6e-13 49.6 0.1 2.5 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESL08514.1 - 1.6e-13 50.2 0.2 9.1e-13 47.8 0.1 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESL08514.1 - 7.5e-11 43.0 0.4 1.9e-10 41.7 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF4147 PF13660.1 ESL08514.1 - 0.016 14.2 0.1 0.31 10.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) ACP_syn_III_C PF08541.5 ESL08514.1 - 0.07 13.1 4.8 0.59 10.1 0.3 2.9 2 1 1 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ABC_tran PF00005.22 ESL08515.1 - 2.5e-19 69.9 0.0 3.5e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL08515.1 - 5.7e-05 22.4 0.1 0.00049 19.4 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 ESL08515.1 - 0.0002 20.5 0.0 0.15 11.1 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.1 ESL08515.1 - 0.00021 21.3 0.0 0.45 10.4 0.1 2.2 1 1 1 2 2 2 2 AAA domain AAA_23 PF13476.1 ESL08515.1 - 0.00034 21.0 0.0 0.00054 20.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ESL08515.1 - 0.0007 19.0 0.4 0.0014 18.0 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.1 ESL08515.1 - 0.0024 17.5 0.4 0.018 14.7 0.1 2.4 3 0 0 3 3 3 1 Part of AAA domain AAA_17 PF13207.1 ESL08515.1 - 0.0057 17.4 0.0 0.011 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESL08515.1 - 0.0066 15.6 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESL08515.1 - 0.0069 16.5 0.1 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESL08515.1 - 0.007 15.7 0.0 0.051 12.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESL08515.1 - 0.02 14.5 0.4 0.039 13.5 0.3 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESL08515.1 - 0.024 14.3 0.1 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 NTPase AAA_16 PF13191.1 ESL08515.1 - 0.037 14.0 0.1 0.067 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.17 ESL08515.1 - 0.039 12.8 0.1 0.08 11.7 0.0 1.5 1 1 0 1 1 1 0 NB-ARC domain AAA PF00004.24 ESL08515.1 - 0.039 14.1 0.3 0.23 11.6 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 ESL08515.1 - 0.053 12.9 0.3 0.09 12.2 0.2 1.3 1 0 0 1 1 1 0 AAA-like domain MMR_HSR1 PF01926.18 ESL08515.1 - 0.055 13.4 0.1 0.1 12.5 0.1 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.7 ESL08515.1 - 0.061 12.9 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 NACHT domain PRK PF00485.13 ESL08515.1 - 0.075 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family TIP49 PF06068.8 ESL08515.1 - 0.1 11.2 0.1 0.21 10.2 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus PduV-EutP PF10662.4 ESL08515.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation UPF0079 PF02367.12 ESL08515.1 - 0.12 11.9 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF87 PF01935.12 ESL08515.1 - 0.15 11.8 0.6 0.3 10.8 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 Mg_chelatase PF01078.16 ESL08515.1 - 0.29 10.2 1.5 0.89 8.6 0.4 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2435 PF10363.4 ESL08516.1 - 0.063 13.1 0.2 0.65 9.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2435) HEAT PF02985.17 ESL08516.1 - 0.093 12.8 2.6 12 6.2 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat TRAPP PF04051.11 ESL08517.1 - 2e-26 92.3 0.0 2.5e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SPW PF03779.9 ESL08517.1 - 0.0021 17.3 0.3 0.0041 16.4 0.2 1.4 1 0 0 1 1 1 1 SPW repeat OmpH PF03938.9 ESL08518.1 - 0.0006 19.7 7.7 0.1 12.5 0.1 2.6 3 0 0 3 3 3 2 Outer membrane protein (OmpH-like) TPR_20 PF14561.1 ESL08518.1 - 0.061 13.4 0.9 0.2 11.8 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Fez1 PF06818.10 ESL08518.1 - 0.12 12.4 8.3 0.26 11.2 5.7 1.6 1 0 0 1 1 1 0 Fez1 Baculo_PEP_C PF04513.7 ESL08518.1 - 0.13 12.0 1.6 1.2 8.9 1.1 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4168 PF13767.1 ESL08518.1 - 0.34 11.5 2.2 14 6.4 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4168) Bacillus_HBL PF05791.6 ESL08518.1 - 0.37 10.1 5.6 0.24 10.7 1.2 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Cluap1 PF10234.4 ESL08518.1 - 0.39 9.8 8.2 3.4 6.8 1.6 2.3 1 1 1 2 2 2 0 Clusterin-associated protein-1 Spc7 PF08317.6 ESL08518.1 - 0.95 8.0 7.8 1.6 7.3 5.2 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein MerR-DNA-bind PF09278.6 ESL08518.1 - 1.1 9.7 5.9 0.56 10.6 0.3 3.1 4 0 0 4 4 4 0 MerR, DNA binding APG6 PF04111.7 ESL08518.1 - 1.2 8.0 5.4 4.6 6.1 2.9 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.7 ESL08518.1 - 2.5 7.8 8.3 3.5 7.3 0.9 2.8 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 ESL08518.1 - 3 6.6 8.0 17 4.2 5.5 2.2 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 LSM PF01423.17 ESL08519.1 - 1.2e-08 34.3 0.0 1.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain RIX1 PF08167.7 ESL08520.1 - 0.096 12.3 10.8 8.7 5.9 0.1 4.3 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis Thymidylat_synt PF00303.14 ESL08521.1 - 6.4e-112 372.9 0.0 1.4e-111 371.8 0.0 1.5 2 0 0 2 2 2 1 Thymidylate synthase zf-C2H2_jaz PF12171.3 ESL08522.1 - 2e-06 27.7 1.6 3.7e-06 26.9 1.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.7 ESL08522.1 - 0.00095 18.6 0.9 0.0015 18.0 0.6 1.3 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.2 ESL08522.1 - 0.0028 17.8 1.7 0.0028 17.8 1.1 1.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESL08522.1 - 0.075 13.1 0.2 0.097 12.7 0.1 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) PSRT PF07636.6 ESL08522.1 - 0.13 11.7 0.1 0.13 11.7 0.0 1.9 3 0 0 3 3 3 0 PSRT Y_phosphatase3C PF13348.1 ESL08525.1 - 0.007 16.4 0.0 0.019 15.0 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region NAP PF00956.13 ESL08526.1 - 7.5e-17 61.2 0.1 3.1e-16 59.2 0.0 1.8 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Aa_trans PF01490.13 ESL08531.1 - 2.2e-51 174.6 36.9 2.5e-51 174.4 25.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 ESL08531.1 - 1.1e-05 24.2 10.4 1.1e-05 24.2 7.2 2.6 1 1 0 2 2 2 1 Amino acid permease Trp_Tyr_perm PF03222.8 ESL08531.1 - 0.00011 21.1 32.4 0.0073 15.1 22.3 2.7 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family Varsurf_PPLC PF03490.8 ESL08535.1 - 1.7e-28 98.0 0.4 3.8e-28 96.9 0.3 1.6 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C PI-PLC-X PF00388.14 ESL08535.1 - 1.8e-06 27.4 0.0 2.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DHFR_1 PF00186.14 ESL08536.1 - 3.8e-21 75.3 0.0 4.6e-20 71.8 0.0 2.0 1 1 0 1 1 1 1 Dihydrofolate reductase TPR_14 PF13428.1 ESL08537.1 - 4.5e-14 51.6 24.7 0.0039 17.6 0.0 10.0 7 1 3 11 11 10 6 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08537.1 - 9.1e-07 28.3 0.9 4.1 7.5 0.3 5.5 4 0 0 4 4 4 2 Tetratricopeptide repeat HAT PF02184.11 ESL08537.1 - 2.1e-06 27.3 12.4 0.82 9.4 0.0 7.5 8 0 0 8 8 8 2 HAT (Half-A-TPR) repeat TPR_19 PF14559.1 ESL08537.1 - 3.1e-06 27.4 3.4 0.0099 16.1 0.0 5.8 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL08537.1 - 0.00012 21.9 7.3 0.39 10.6 0.1 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat NRDE-2 PF08424.5 ESL08537.1 - 0.00018 20.4 6.3 0.16 10.7 0.5 3.4 4 0 0 4 4 4 2 NRDE-2, necessary for RNA interference TPR_16 PF13432.1 ESL08537.1 - 0.00024 21.7 35.8 0.31 11.7 0.0 8.4 10 1 1 11 11 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESL08537.1 - 0.00024 20.8 7.2 0.0072 16.1 0.1 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL08537.1 - 0.0014 18.6 1.5 0.035 14.2 0.0 3.3 4 0 0 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESL08537.1 - 0.0036 17.6 12.0 29 5.4 0.0 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08537.1 - 0.011 15.5 3.0 1.7 8.6 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Suf PF05843.9 ESL08537.1 - 0.016 14.9 5.4 13 5.3 0.0 4.3 5 0 0 5 5 5 0 Suppressor of forked protein (Suf) TPR_17 PF13431.1 ESL08537.1 - 0.024 14.8 0.1 13 6.3 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2063 PF09836.4 ESL08537.1 - 0.035 14.1 0.9 0.21 11.6 0.0 2.8 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2063) PPR PF01535.15 ESL08537.1 - 0.046 13.7 0.5 3.5 7.8 0.0 3.9 4 0 0 4 4 3 0 PPR repeat DUF3808 PF10300.4 ESL08537.1 - 0.05 12.1 2.1 0.048 12.2 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) TPR_8 PF13181.1 ESL08537.1 - 0.062 13.1 0.0 3.8 7.5 0.0 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat Aa_trans PF01490.13 ESL08538.1 - 5.3e-09 35.0 7.8 5.9e-09 34.9 5.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4231 PF14015.1 ESL08538.1 - 0.24 11.4 2.8 0.18 11.8 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Polysacc_synt_C PF14667.1 ESL08538.1 - 1.7 8.4 14.0 2.8 7.7 9.8 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain UPF0093 PF03653.8 ESL08538.1 - 2.2 8.2 6.3 0.54 10.1 1.9 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0093) NifU PF01106.12 ESL08539.1 - 2.7e-17 62.2 0.2 5.1e-17 61.4 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.6 ESL08539.1 - 2.7e-09 36.5 0.0 2.4e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 Scaffold protein Nfu/NifU N terminal PPR_2 PF13041.1 ESL08540.1 - 0.00025 20.9 0.2 1.2 9.2 0.0 4.3 5 0 0 5 5 5 2 PPR repeat family PPR PF01535.15 ESL08540.1 - 0.29 11.2 2.7 12 6.1 0.0 3.8 3 0 0 3 3 3 0 PPR repeat DUF972 PF06156.8 ESL08541.1 - 5.1 7.4 49.2 1.1 9.5 0.3 9.4 4 2 6 10 10 10 0 Protein of unknown function (DUF972) CENP-F_leu_zip PF10473.4 ESL08541.1 - 8.7 6.2 77.6 0.62 9.9 2.3 7.9 4 3 1 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 3HCDH PF00725.17 ESL08542.1 - 1.2e-09 38.4 0.0 0.00032 21.0 0.0 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH PF00378.15 ESL08542.1 - 3.6e-05 22.9 0.0 7.6e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Hexokinase_1 PF00349.16 ESL08543.1 - 4.6e-64 215.5 0.1 6.9e-64 214.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 ESL08543.1 - 4.2e-58 196.4 0.1 5.9e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Nodulin-like PF06813.8 ESL08544.1 - 2.3e-12 46.7 5.6 2.3e-12 46.7 3.9 2.6 2 0 0 2 2 2 2 Nodulin-like N2227 PF07942.7 ESL08546.1 - 1.4e-94 316.0 0.0 1.8e-94 315.7 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein MAS20 PF02064.10 ESL08547.1 - 0.064 13.1 2.3 0.18 11.7 1.6 1.8 1 0 0 1 1 1 0 MAS20 protein import receptor DUF3756 PF12581.3 ESL08547.1 - 0.11 12.2 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) PSP1 PF04468.7 ESL08548.1 - 7.8e-16 57.8 0.0 1.2e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Ras PF00071.17 ESL08550.1 - 6e-59 198.0 0.1 7.1e-59 197.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL08550.1 - 4.3e-19 69.1 0.0 6.4e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL08550.1 - 1.7e-13 50.1 0.0 2.1e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESL08550.1 - 1.9e-06 27.7 0.0 3.4e-06 26.9 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL08550.1 - 2.2e-06 27.2 0.0 1.9e-05 24.1 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 ESL08550.1 - 0.0054 16.8 0.0 0.0092 16.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESL08550.1 - 0.0061 15.7 0.0 0.0093 15.1 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESL08550.1 - 0.0062 15.6 0.0 0.0077 15.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 ESL08550.1 - 0.0063 15.7 0.1 0.014 14.5 0.0 1.7 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 ESL08550.1 - 0.048 12.7 0.0 0.059 12.4 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.1 ESL08550.1 - 0.051 13.1 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Septin PF00735.13 ESL08550.1 - 0.06 12.3 0.1 0.084 11.8 0.0 1.2 1 0 0 1 1 1 0 Septin Amidase02_C PF12123.3 ESL08550.1 - 0.086 12.4 0.1 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase FeoB_N PF02421.13 ESL08550.1 - 0.11 11.7 0.0 0.41 9.9 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.1 ESL08550.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 ESL08550.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain Methyltransf_16 PF10294.4 ESL08551.1 - 9.2e-12 44.7 0.0 2.5e-08 33.5 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase MTS PF05175.9 ESL08551.1 - 2.5e-09 36.7 0.0 9.7e-09 34.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.2 ESL08551.1 - 3.2e-06 27.6 0.0 6.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL08551.1 - 0.001 19.5 0.1 0.0093 16.4 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL08551.1 - 0.0058 16.2 0.0 0.014 14.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Borrelia_orfD PF02999.9 ESL08551.1 - 0.018 15.1 0.1 0.072 13.2 0.0 2.0 2 0 0 2 2 2 0 Borrelia orf-D family Methyltransf_25 PF13649.1 ESL08551.1 - 0.043 14.1 0.1 0.096 13.0 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Complex1_LYR PF05347.10 ESL08553.1 - 0.00047 19.8 0.6 0.001 18.8 0.4 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESL08553.1 - 0.097 12.9 0.5 0.21 11.8 0.4 1.6 1 0 0 1 1 1 0 Complex1_LYR-like Epimerase PF01370.16 ESL08554.1 - 2.8e-39 134.9 0.0 4e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 ESL08554.1 - 6.7e-14 51.5 0.0 1.1e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 ESL08554.1 - 2.2e-13 49.5 0.0 1.6e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 ESL08554.1 - 1.6e-12 46.9 0.0 4.8e-12 45.3 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 ESL08554.1 - 2e-09 36.7 0.0 2.9e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.20 ESL08554.1 - 7.5e-08 32.4 0.1 1.6e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL08554.1 - 9.5e-07 28.6 0.1 2.8e-06 27.1 0.1 1.7 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.12 ESL08554.1 - 2.4e-06 26.6 0.0 1.7e-05 23.9 0.0 2.2 2 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 ESL08554.1 - 0.00044 20.2 0.5 0.86 9.5 0.0 2.3 2 0 0 2 2 2 2 NADH(P)-binding NmrA PF05368.8 ESL08554.1 - 0.02 14.1 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Amastin PF07344.6 ESL08555.1 - 8.5e-22 77.4 30.5 6.4e-16 58.3 8.8 2.2 2 0 0 2 2 2 2 Amastin surface glycoprotein CRAL_TRIO PF00650.15 ESL08556.1 - 2.7e-10 39.9 0.0 5.1e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 ESL08556.1 - 0.0067 16.3 0.1 0.031 14.1 0.0 1.9 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Cpn60_TCP1 PF00118.19 ESL08557.1 - 1e-143 479.5 0.1 1.2e-143 479.3 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AP_endonuc_2 PF01261.19 ESL08557.1 - 0.071 12.3 0.0 0.22 10.7 0.0 1.7 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Resolvase PF00239.16 ESL08557.1 - 0.13 12.0 0.8 0.34 10.7 0.1 2.0 2 0 0 2 2 2 0 Resolvase, N terminal domain WD40 PF00400.27 ESL08558.1 - 1.2e-16 59.8 14.4 1.1e-05 25.0 0.6 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat Aminotran_5 PF00266.14 ESL08559.1 - 3.7e-13 48.9 0.0 1.1e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ESL08559.1 - 3.3e-06 26.4 0.2 2e-05 23.8 0.1 2.0 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 ESL08559.1 - 0.0016 16.8 0.0 0.0022 16.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme EIF_2_alpha PF07541.7 ESL08560.1 - 7e-24 83.7 0.0 1.3e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 ESL08560.1 - 9.7e-10 38.4 1.2 1.8e-09 37.5 0.8 1.5 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.4 ESL08560.1 - 0.0027 17.6 0.7 0.0058 16.5 0.5 1.6 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 PUF PF00806.14 ESL08561.1 - 9e-21 72.1 1.4 0.00036 19.8 0.0 5.6 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat HSP70 PF00012.15 ESL08562.1 - 1.4e-259 862.1 12.9 1.6e-259 861.9 8.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL08562.1 - 8e-20 70.6 0.5 6.2e-17 61.1 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 ESL08562.1 - 0.00015 21.4 0.0 0.00055 19.6 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 ESL08562.1 - 0.0018 17.4 0.1 0.0018 17.4 0.1 2.8 4 0 0 4 4 4 1 Hydantoinase/oxoprolinase RE_HindIII PF09518.5 ESL08562.1 - 1.5 7.6 6.7 0.15 10.9 0.6 2.1 3 0 0 3 3 3 0 HindIII restriction endonuclease Inositol_P PF00459.20 ESL08563.1 - 1.9e-64 217.6 0.2 2.2e-64 217.4 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family TORC_N PF12884.2 ESL08564.1 - 0.031 14.8 0.0 0.031 14.8 0.0 3.6 3 0 0 3 3 3 0 Transducer of regulated CREB activity, N terminus ECH_C PF13766.1 ESL08566.1 - 4.5e-34 117.1 0.0 6e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 ESL08566.1 - 1.5e-12 47.2 0.0 1.5e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Dynein_light PF01221.13 ESL08567.1 - 7.1e-20 70.7 0.0 8.7e-20 70.5 0.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 tRNA-synt_2c PF01411.14 ESL08568.1 - 1.8e-190 633.8 0.0 2.3e-190 633.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 ESL08568.1 - 9.1e-11 41.4 0.1 2.6e-10 39.9 0.0 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 ESL08568.1 - 1.8e-05 24.3 0.7 5.7e-05 22.7 0.5 1.9 1 0 0 1 1 1 1 DHHA1 domain ACP_syn_III PF08545.5 ESL08569.1 - 0.0022 17.6 0.1 0.022 14.3 0.1 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Mu-like_Com PF10122.4 ESL08570.1 - 0.0023 16.9 0.4 0.0023 16.9 0.2 4.1 3 2 1 4 4 4 1 Mu-like prophage protein Com zf-CHY PF05495.7 ESL08570.1 - 0.0044 17.1 17.8 0.76 9.9 0.5 4.1 1 1 3 4 4 4 3 CHY zinc finger zf-Sec23_Sec24 PF04810.10 ESL08570.1 - 0.018 14.5 13.2 0.24 10.9 0.1 3.7 4 0 0 4 4 4 0 Sec23/Sec24 zinc finger DUF3133 PF11331.3 ESL08570.1 - 0.41 10.2 25.4 0.38 10.3 0.3 5.2 3 2 2 5 5 5 0 Protein of unknown function (DUF3133) DZR PF12773.2 ESL08570.1 - 0.64 9.8 18.7 17 5.3 4.5 4.1 1 1 2 3 3 3 0 Double zinc ribbon DUF2296 PF10058.4 ESL08570.1 - 0.71 9.6 14.3 0.57 9.9 0.1 4.1 4 0 0 4 4 4 0 Predicted integral membrane metal-binding protein (DUF2296) Zn_Tnp_IS1595 PF12760.2 ESL08570.1 - 2.9 7.7 16.0 0.86 9.4 0.2 3.7 2 1 0 2 2 2 0 Transposase zinc-ribbon domain C1_4 PF07975.7 ESL08570.1 - 4 7.5 20.9 2.2 8.3 0.8 4.6 2 2 2 4 4 4 0 TFIIH C1-like domain Cytochrom_c3_2 PF14537.1 ESL08570.1 - 4.4 7.7 11.9 13 6.2 3.8 2.7 1 1 2 3 3 3 0 Cytochrome c3 YABBY PF04690.8 ESL08570.1 - 5.1 7.3 10.7 6.3 7.0 1.1 3.3 2 1 1 3 3 3 0 YABBY protein zinc_ribbon_5 PF13719.1 ESL08570.1 - 8 6.1 24.0 11 5.6 0.2 5.4 4 2 1 5 5 5 0 zinc-ribbon domain Cofilin_ADF PF00241.15 ESL08571.1 - 4.8e-29 100.8 0.2 5.4e-29 100.6 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein IQ PF00612.22 ESL08572.1 - 3.6e-18 63.4 78.0 0.00038 19.8 0.0 14.6 14 0 0 14 14 14 10 IQ calmodulin-binding motif ANT PF03374.9 ESL08572.1 - 0.0039 17.2 1.1 0.017 15.1 0.1 2.5 2 1 0 2 2 2 1 Phage antirepressor protein KilAC domain DUF2215 PF10225.4 ESL08572.1 - 0.51 9.7 4.5 0.15 11.4 0.6 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) META PF03724.11 ESL08573.1 - 3.6e-10 39.5 0.0 4.5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 META domain WD40 PF00400.27 ESL08574.1 - 1.1e-15 56.8 12.6 6.7e-07 28.9 0.1 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.1 ESL08574.1 - 0.036 14.3 1.0 24 5.3 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain Peptidase_M8 PF01457.11 ESL08575.1 - 1.1e-122 410.0 0.0 1.4e-122 409.6 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin SprT-like PF10263.4 ESL08575.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 SprT-like family Astacin PF01400.19 ESL08575.1 - 0.2 11.0 0.2 0.55 9.5 0.0 1.7 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) PilJ PF13675.1 ESL08577.1 - 0.003 17.8 1.3 0.0047 17.2 0.9 1.3 1 0 0 1 1 1 1 Type IV pili methyl-accepting chemotaxis transducer N-term DUF603 PF04645.7 ESL08577.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF603 MerR-DNA-bind PF09278.6 ESL08577.1 - 0.16 12.3 4.6 2.9 8.3 1.2 2.4 1 1 1 2 2 2 0 MerR, DNA binding Harakiri PF15196.1 ESL08577.1 - 0.37 11.0 4.6 2.6 8.3 0.1 2.2 2 0 0 2 2 2 0 Activator of apoptosis harakiri ApoO PF09769.4 ESL08578.1 - 0.7 9.5 10.4 1.5 8.5 4.3 3.2 2 1 0 2 2 2 0 Apolipoprotein O Peptidase_C3 PF00548.15 ESL08578.1 - 4.1 7.1 8.2 0.35 10.6 0.8 2.8 3 1 1 4 4 4 0 3C cysteine protease (picornain 3C) Syntaxin-6_N PF09177.6 ESL08579.1 - 0.045 14.1 4.1 0.32 11.4 2.5 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal L31 PF09784.4 ESL08579.1 - 0.057 13.4 0.6 0.16 12.0 0.0 2.0 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 Baculo_PEP_C PF04513.7 ESL08579.1 - 0.58 9.9 2.8 3 7.6 0.1 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus WXG100 PF06013.7 ESL08579.1 - 1 9.4 7.4 5.4 7.0 1.8 3.1 2 1 1 3 3 3 0 Proteins of 100 residues with WXG LRR_4 PF12799.2 ESL08581.1 - 0.00029 20.3 0.3 0.0066 16.0 0.0 2.7 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESL08581.1 - 0.05 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat LRR_8 PF13855.1 ESL08581.1 - 0.084 12.6 0.3 0.19 11.4 0.2 1.6 1 0 0 1 1 1 0 Leucine rich repeat ATP-synt_ab_N PF02874.18 ESL08582.1 - 0.13 12.4 0.1 0.51 10.5 0.1 2.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain 5_3_exonuc PF01367.15 ESL08583.1 - 1.2e-19 70.3 0.0 2.2e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.11 ESL08583.1 - 5.1e-15 55.2 1.6 1.7e-12 47.0 1.1 3.0 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain Folliculin PF11704.3 ESL08586.1 - 4.6e-12 45.8 0.0 9e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport SlyX PF04102.7 ESL08587.1 - 0.48 10.8 6.3 19 5.7 0.0 3.4 3 0 0 3 3 3 0 SlyX DnaJ PF00226.26 ESL08588.1 - 3.1e-07 30.0 0.0 6.7e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain LEP503 PF15221.1 ESL08588.1 - 0.24 11.1 2.7 0.73 9.5 1.9 1.8 1 1 0 1 1 1 0 Lens epithelial cell protein LEP503 Kinesin PF00225.18 ESL08590.1 - 6.1e-44 150.0 0.0 7e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 ESL08590.1 - 0.087 12.9 0.0 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain WASH-7_N PF14745.1 ESL08593.1 - 6.9e-160 532.9 3.6 1.1e-159 532.3 2.5 1.3 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal WASH-7_mid PF14744.1 ESL08593.1 - 2.1e-148 493.8 0.0 4.4e-148 492.8 0.0 1.6 1 0 0 1 1 1 1 WASH complex subunit 7 WASH-7_C PF14746.1 ESL08593.1 - 1.5e-60 203.6 0.5 3.1e-60 202.6 0.3 1.6 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Sod_Fe_C PF02777.13 ESL08594.1 - 7.5e-06 25.7 0.0 2.3e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain ArfGap PF01412.13 ESL08594.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Tcp10_C PF07202.8 ESL08594.1 - 0.067 12.7 0.1 0.27 10.7 0.0 1.8 1 1 0 1 1 1 0 T-complex protein 10 C-terminus IER PF05760.7 ESL08594.1 - 2.4 8.0 6.9 6.4 6.6 3.9 1.9 1 1 0 1 1 1 0 Immediate early response protein (IER) BOP1NT PF08145.7 ESL08595.1 - 1.7e-87 293.4 8.3 2.8e-87 292.7 5.7 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 ESL08595.1 - 2.6e-12 46.1 0.0 3.2e-10 39.4 0.0 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat BpuJI_N PF11564.3 ESL08595.1 - 0.021 13.7 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal CagA PF03507.8 ESL08596.1 - 0.013 15.3 0.1 0.024 14.4 0.1 1.3 1 0 0 1 1 1 0 CagA exotoxin PV-1 PF06637.6 ESL08596.1 - 0.024 13.2 4.3 0.048 12.2 3.0 1.4 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF948 PF06103.6 ESL08596.1 - 0.027 14.3 2.9 0.35 10.7 0.0 3.5 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) FliD_C PF07195.7 ESL08596.1 - 0.037 13.3 0.1 1.1 8.4 0.0 2.6 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus DUF2205 PF10224.4 ESL08596.1 - 0.096 12.2 7.4 0.86 9.2 0.4 3.3 3 0 0 3 3 3 0 Predicted coiled-coil protein (DUF2205) Mnd1 PF03962.10 ESL08596.1 - 0.19 11.4 9.1 0.33 10.6 1.1 3.0 2 1 1 3 3 3 0 Mnd1 family PEP-utilisers_N PF05524.8 ESL08596.1 - 0.2 11.4 7.5 0.42 10.4 2.1 3.1 2 1 1 3 3 3 0 PEP-utilising enzyme, N-terminal Ribosomal_S13 PF00416.17 ESL08596.1 - 0.72 10.3 4.2 1.2 9.6 0.1 2.9 2 1 0 3 3 3 0 Ribosomal protein S13/S18 ING PF12998.2 ESL08596.1 - 4.9 7.4 7.8 0.69 10.2 0.8 3.1 2 1 2 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding V_ATPase_I PF01496.14 ESL08596.1 - 9.5 3.9 9.2 11 3.6 4.6 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family IncA PF04156.9 ESL08596.1 - 9.8 5.7 10.2 4 6.9 0.3 2.9 2 1 1 3 3 3 0 IncA protein Gryzun PF07919.7 ESL08597.1 - 6.6e-47 160.0 0.0 9.7e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi TRAPPC10 PF12584.3 ESL08597.1 - 0.0029 17.0 0.0 0.0065 15.9 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Gryzun-like PF12742.2 ESL08597.1 - 0.022 14.5 0.2 0.075 12.8 0.0 2.0 2 0 0 2 2 2 0 Gryzun, putative Golgi trafficking UCR_Fe-S_N PF10399.4 ESL08597.1 - 0.079 12.1 0.2 0.18 10.9 0.2 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal SNARE PF05739.14 ESL08598.1 - 2.6e-14 52.6 2.3 5.9e-14 51.5 0.1 2.6 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESL08598.1 - 7.9e-13 48.4 4.5 1.3e-11 44.5 0.7 2.4 2 0 0 2 2 2 1 Syntaxin Herpes_US9 PF06072.6 ESL08598.1 - 0.0021 17.8 2.3 0.0021 17.8 1.6 2.1 2 0 0 2 2 2 1 Alphaherpesvirus tegument protein US9 Spc7 PF08317.6 ESL08598.1 - 0.045 12.4 8.9 0.0094 14.6 3.1 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein CCP_MauG PF03150.9 ESL08598.1 - 0.37 11.0 2.1 0.48 10.7 0.7 1.7 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase DUF1664 PF07889.7 ESL08598.1 - 2.4 7.9 6.5 2.6 7.8 0.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) zf-CCCH PF00642.19 ESL08599.1 - 1.1e-08 34.5 0.7 1.9e-08 33.7 0.5 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) WW PF00397.21 ESL08599.1 - 1.5e-06 27.9 0.8 1.5e-06 27.9 0.6 1.7 2 0 0 2 2 2 1 WW domain HMGL-like PF00682.14 ESL08600.1 - 1.7e-19 70.4 0.0 2.7e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 HMGL-like Creatinase_N PF01321.13 ESL08600.1 - 0.082 13.4 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain Ins134_P3_kin PF05770.6 ESL08601.1 - 6.5e-06 25.3 0.0 0.04 12.9 0.0 2.7 3 0 0 3 3 3 2 Inositol 1, 3, 4-trisphosphate 5/6-kinase CLAMP PF14769.1 ESL08602.1 - 1.9e-30 104.9 0.3 3.2e-30 104.2 0.2 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 CobN-Mg_chel PF02514.11 ESL08605.1 - 0.0017 15.8 0.1 0.002 15.6 0.1 1.1 1 0 0 1 1 1 1 CobN/Magnesium Chelatase FlhD PF05247.8 ESL08605.1 - 0.1 12.6 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhD) V_ATPase_I PF01496.14 ESL08605.1 - 0.17 9.7 1.6 0.77 7.5 0.0 1.9 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family Med9 PF07544.8 ESL08605.1 - 0.3 10.8 1.9 2.5 7.8 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Rab5-bind PF09311.6 ESL08605.1 - 0.31 10.9 9.3 0.71 9.7 6.5 1.6 1 1 0 1 1 1 0 Rabaptin-like protein IncA PF04156.9 ESL08605.1 - 3.3 7.2 10.4 0.45 10.0 0.4 2.2 2 0 0 2 2 2 0 IncA protein Ribosomal_S8 PF00410.14 ESL08608.1 - 1.8e-11 43.9 0.0 2.6e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S8 Coatomer_WDAD PF04053.9 ESL08609.1 - 1e-141 472.7 0.0 1.6e-141 472.1 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 ESL08609.1 - 2.5e-39 131.7 0.5 4.5e-08 32.6 0.2 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Pkinase PF00069.20 ESL08610.1 - 2e-35 122.2 0.0 5e-34 117.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08610.1 - 2.5e-21 75.9 0.0 4.6e-21 75.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ESL08610.1 - 0.0018 17.6 0.0 0.0033 16.7 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESL08610.1 - 0.0039 16.9 0.9 0.0072 16.0 0.6 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL08610.1 - 0.015 14.4 0.0 0.026 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Halo_GVPC PF05465.8 ESL08610.1 - 0.068 13.1 0.2 0.19 11.7 0.1 1.8 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat Mem_trans PF03547.13 ESL08611.1 - 5.6e-15 54.5 20.7 3.9e-08 31.9 0.2 4.0 3 1 0 3 3 3 3 Membrane transport protein RNA_pol_Rpb2_6 PF00562.23 ESL08612.1 - 2e-86 290.1 0.0 2.8e-86 289.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpa2_4 PF06883.7 ESL08612.1 - 2.9e-15 55.9 0.1 1.1e-14 54.0 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_3 PF04565.11 ESL08612.1 - 1.8e-14 53.2 0.0 4.1e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.15 ESL08612.1 - 6.3e-13 48.7 0.2 2.3e-12 47.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.10 ESL08612.1 - 9.1e-09 34.5 0.0 2.5e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase beta subunit PDCD2_C PF04194.8 ESL08613.1 - 7.5e-20 71.1 0.1 7.5e-20 71.1 0.1 1.9 2 1 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain Zn_Tnp_IS1595 PF12760.2 ESL08613.1 - 0.00017 21.3 0.9 0.36 10.6 0.1 2.9 2 1 0 2 2 2 2 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 ESL08613.1 - 0.0021 17.7 0.3 3.9 7.3 0.0 3.4 3 0 0 3 3 3 2 PhnA Zinc-Ribbon zf-ribbon_3 PF13248.1 ESL08613.1 - 0.066 12.4 5.7 0.33 10.2 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESL08613.1 - 0.13 11.8 5.7 0.18 11.3 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Cys_Met_Meta_PP PF01053.15 ESL08614.1 - 3.5e-127 423.9 0.0 3.9e-127 423.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ESL08614.1 - 1.4e-12 47.3 0.4 2.9e-12 46.3 0.3 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 ESL08614.1 - 1.7e-09 37.0 0.0 2.4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 ESL08614.1 - 8.1e-08 31.7 0.1 1.4e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 ESL08614.1 - 3.3e-07 29.3 0.0 5.8e-07 28.5 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V BBS2_Mid PF14783.1 ESL08615.1 - 2.8e-07 30.2 0.0 8.6e-06 25.4 0.0 3.0 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region BBS2_C PF14782.1 ESL08615.1 - 0.0017 16.9 0.5 0.21 10.1 0.0 2.6 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, C-terminal FG-GAP PF01839.18 ESL08615.1 - 0.17 11.6 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 FG-GAP repeat HEAT_2 PF13646.1 ESL08616.1 - 3.7e-11 43.1 0.1 1.4e-05 25.2 0.0 3.7 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.17 ESL08616.1 - 1.9e-07 30.5 15.6 0.013 15.4 0.1 6.5 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 ESL08616.1 - 0.033 14.7 3.5 37 4.9 0.0 4.5 2 2 2 4 4 4 0 HEAT-like repeat Adaptin_N PF01602.15 ESL08616.1 - 0.05 11.9 0.2 0.49 8.6 0.0 2.2 2 0 0 2 2 2 0 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 ESL08616.1 - 0.06 13.7 0.0 0.61 10.5 0.0 2.5 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF3585 PF12130.3 ESL08616.1 - 0.16 11.8 1.0 0.25 11.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3585) DnaJ PF00226.26 ESL08618.1 - 2e-08 33.8 0.0 3.7e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Phos_pyr_kin PF08543.7 ESL08619.1 - 3.3e-16 59.2 0.0 4.7e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 ESL08619.1 - 7.3e-13 48.3 0.3 4.2e-10 39.2 0.0 2.9 2 1 0 2 2 2 2 pfkB family carbohydrate kinase DnaJ PF00226.26 ESL08620.1 - 4.6e-20 71.1 0.3 7e-20 70.5 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain TBPIP PF07106.8 ESL08621.1 - 0.11 12.0 0.0 0.33 10.4 0.0 1.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Ribosomal_L40e PF01020.12 ESL08622.1 - 2.7e-34 116.5 13.0 2.9e-34 116.4 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L40e family zf-CHY PF05495.7 ESL08622.1 - 0.014 15.4 3.3 0.017 15.2 2.3 1.1 1 0 0 1 1 1 0 CHY zinc finger VWC PF00093.13 ESL08622.1 - 0.017 15.2 2.8 0.02 14.9 2.0 1.1 1 0 0 1 1 1 0 von Willebrand factor type C domain SBP PF03110.9 ESL08622.1 - 0.023 14.9 2.7 0.025 14.7 1.9 1.1 1 0 0 1 1 1 0 SBP domain DZR PF12773.2 ESL08622.1 - 0.034 13.9 2.9 0.047 13.5 2.0 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS91 PF14319.1 ESL08622.1 - 0.037 13.5 4.1 0.04 13.4 2.9 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-DHHC PF01529.15 ESL08622.1 - 0.58 9.5 3.5 0.65 9.3 2.5 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF4428 PF14471.1 ESL08622.1 - 0.69 9.7 3.3 18 5.1 2.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) FYVE PF01363.16 ESL08622.1 - 2.4 8.1 8.5 5.4 6.9 0.4 2.0 1 1 1 2 2 2 0 FYVE zinc finger Pkinase PF00069.20 ESL08623.1 - 1.8e-18 66.6 0.0 6.2e-18 64.8 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08623.1 - 1.9e-09 37.0 0.0 4.8e-09 35.6 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Cob_adeno_trans PF01923.13 ESL08623.1 - 0.059 13.1 0.2 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF3147 PF11345.3 ESL08625.1 - 0.03 14.3 0.5 0.12 12.4 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) T4_Gp59_C PF08994.5 ESL08625.1 - 0.15 12.2 0.1 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term CD52 PF15116.1 ESL08626.1 - 0.55 10.0 6.1 0.36 10.6 0.2 2.9 2 0 0 2 2 2 0 CAMPATH-1 antigen Pro_isomerase PF00160.16 ESL08627.1 - 1.2e-41 142.4 0.0 1.4e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PGM_PMM_I PF02878.11 ESL08628.1 - 4.4e-39 133.1 0.0 8e-39 132.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 ESL08628.1 - 3.4e-21 75.5 0.0 1.2e-20 73.7 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 ESL08628.1 - 2e-10 40.6 0.1 3.7e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 ESL08628.1 - 1.7e-05 24.6 0.0 5.1e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain MerR-DNA-bind PF09278.6 ESL08629.1 - 0.0066 16.8 9.0 0.0066 16.8 6.2 4.1 4 1 0 4 4 4 1 MerR, DNA binding SGT1 PF07093.6 ESL08629.1 - 0.025 12.9 20.0 0.03 12.7 13.8 1.0 1 0 0 1 1 1 0 SGT1 protein UPF0102 PF02021.12 ESL08629.1 - 0.1 12.5 0.4 0.1 12.5 0.3 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0102 Cyclin_C PF02984.14 ESL08629.1 - 0.11 12.4 0.1 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Cyclin, C-terminal domain Ras PF00071.17 ESL08631.1 - 3.4e-59 198.8 0.2 4.2e-59 198.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL08631.1 - 2.2e-22 79.7 0.0 3.3e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL08631.1 - 1.6e-13 50.2 0.0 2.1e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL08631.1 - 5.8e-05 22.5 0.0 0.00031 20.2 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL08631.1 - 0.00032 19.9 0.0 0.00039 19.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESL08631.1 - 0.0004 19.6 0.0 0.00063 19.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESL08631.1 - 0.0028 17.5 0.0 0.0051 16.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESL08631.1 - 0.034 14.2 0.0 3.4 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESL08631.1 - 0.034 13.6 0.1 0.33 10.4 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NRDE PF05742.7 ESL08631.1 - 0.062 12.5 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 NRDE protein CPT PF07931.7 ESL08631.1 - 0.22 11.1 1.0 0.5 9.9 0.0 2.1 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NOG1 PF06858.9 ESL08632.1 - 3.4e-27 94.0 0.1 1.1e-26 92.4 0.0 1.9 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.6 ESL08632.1 - 1e-23 82.7 4.7 2e-23 81.8 3.3 1.5 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.18 ESL08632.1 - 6.7e-17 61.5 0.0 1.7e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL08632.1 - 2.7e-10 39.7 0.2 7.6e-10 38.2 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 ESL08632.1 - 4.9e-06 27.0 0.0 1.2e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 ESL08632.1 - 0.0084 15.2 0.0 0.018 14.1 0.0 1.6 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.5 ESL08632.1 - 0.03 13.5 0.0 0.053 12.7 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ArgK PF03308.11 ESL08632.1 - 0.038 12.7 0.0 0.3 9.8 0.0 2.2 2 0 0 2 2 2 0 ArgK protein RRM_6 PF14259.1 ESL08633.1 - 8.9e-08 32.0 0.1 2.9e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL08633.1 - 2e-05 24.1 0.1 4.7e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08633.1 - 3.7e-05 23.4 0.0 6.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1190 PF06693.6 ESL08633.1 - 0.026 14.5 0.5 0.051 13.6 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1190) PIF1 PF05970.9 ESL08635.1 - 5e-41 140.8 0.0 6.9e-41 140.3 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 ESL08635.1 - 1.1e-14 54.5 0.0 1.8e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL08635.1 - 2.2e-06 27.8 0.0 4.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL08635.1 - 2.7e-06 27.0 1.1 6.7e-06 25.7 0.7 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 ESL08635.1 - 6.4e-05 23.0 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.1 ESL08635.1 - 0.0013 18.3 0.3 0.14 11.7 0.3 2.4 1 1 1 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 ESL08635.1 - 0.0022 17.5 0.2 0.0086 15.6 0.2 2.0 1 1 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 ESL08635.1 - 0.0043 16.7 0.1 0.015 15.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SE PF00437.15 ESL08635.1 - 0.0081 15.0 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.22 ESL08635.1 - 0.0094 16.2 0.1 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Herpes_Helicase PF02689.9 ESL08635.1 - 0.012 13.4 0.2 0.017 12.9 0.1 1.1 1 0 0 1 1 1 0 Helicase AAA_29 PF13555.1 ESL08635.1 - 0.018 14.5 0.1 0.041 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.24 ESL08635.1 - 0.019 15.1 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESL08635.1 - 0.021 14.3 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AFG1_ATPase PF03969.11 ESL08635.1 - 0.024 13.4 0.0 0.036 12.8 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase NACHT PF05729.7 ESL08635.1 - 0.029 14.0 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.10 ESL08635.1 - 0.03 14.0 0.3 0.46 10.1 0.2 2.2 2 0 0 2 2 2 0 NTPase Helicase_RecD PF05127.9 ESL08635.1 - 0.07 12.7 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Helicase IstB_IS21 PF01695.12 ESL08635.1 - 0.085 12.2 0.0 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.2 ESL08635.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region D3 PhoH PF02562.11 ESL08635.1 - 0.11 11.6 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein MCM PF00493.18 ESL08635.1 - 0.16 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family Bac_DnaA PF00308.13 ESL08635.1 - 0.18 11.4 0.1 0.64 9.6 0.0 1.8 2 0 0 2 2 2 0 Bacterial dnaA protein TIP49 PF06068.8 ESL08635.1 - 0.21 10.2 0.1 4 6.0 0.1 2.0 2 0 0 2 2 2 0 TIP49 C-terminus DUF4194 PF13835.1 ESL08636.1 - 0.15 11.4 0.1 0.26 10.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) CENP-F_leu_zip PF10473.4 ESL08638.1 - 0.0039 17.0 9.9 0.0039 17.0 6.9 3.0 3 0 0 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CH PF00307.26 ESL08638.1 - 0.0076 16.2 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.3 ESL08638.1 - 0.13 11.8 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain Trigger_C PF05698.9 ESL08638.1 - 0.37 10.6 11.3 0.33 10.7 3.3 2.6 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus DUF1664 PF07889.7 ESL08638.1 - 0.96 9.2 3.8 0.96 9.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) OPA3 PF07047.7 ESL08638.1 - 1.2 8.9 10.8 0.061 13.0 0.9 2.7 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) tRNA-synt_1 PF00133.17 ESL08640.1 - 1.1e-216 720.5 1.5 9.5e-216 717.4 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESL08640.1 - 2.3e-24 85.8 0.1 5.2e-24 84.7 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESL08640.1 - 2.9e-18 65.7 0.9 1.5e-07 30.4 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 ESL08640.1 - 0.022 13.8 0.3 0.23 10.5 0.0 2.7 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain DUF2520 PF10728.4 ESL08640.1 - 0.22 10.9 0.0 0.53 9.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) PCI PF01399.22 ESL08641.1 - 6.7e-10 39.2 0.0 1.3e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain HyaE PF07449.6 ESL08641.1 - 0.0071 16.2 0.1 0.083 12.7 0.0 2.4 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE AA_kinase PF00696.23 ESL08641.1 - 0.018 14.5 0.4 0.043 13.3 0.1 1.7 2 0 0 2 2 2 0 Amino acid kinase family TPR_12 PF13424.1 ESL08641.1 - 0.066 13.1 4.9 0.073 13.0 2.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TaqI_C PF12950.2 ESL08641.1 - 0.092 12.4 0.0 3.7 7.3 0.0 2.8 1 1 0 3 3 3 0 TaqI-like C-terminal specificity domain Sugar_tr PF00083.19 ESL08642.1 - 3.5e-12 45.6 2.8 3.8e-12 45.5 1.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL08642.1 - 0.009 14.7 0.0 0.009 14.7 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Syndecan PF01034.15 ESL08642.1 - 0.017 14.7 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Glyco_hydro_92 PF07971.7 ESL08642.1 - 0.058 12.0 0.0 0.071 11.7 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 Rad17 PF03215.10 ESL08643.1 - 0.00022 20.0 0.0 0.00027 19.7 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 ESL08643.1 - 0.00067 19.6 0.0 0.0023 17.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 ESL08643.1 - 0.0024 16.9 0.0 0.47 9.5 0.0 2.3 1 1 1 2 2 2 2 Zeta toxin AAA_18 PF13238.1 ESL08643.1 - 0.008 16.4 0.1 0.028 14.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_26 PF13500.1 ESL08643.1 - 0.008 15.7 0.1 5.6 6.5 0.0 2.7 2 1 1 3 3 3 2 AAA domain AAA_17 PF13207.1 ESL08643.1 - 0.0091 16.8 0.1 0.02 15.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESL08643.1 - 0.0092 15.5 0.0 0.023 14.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 ESL08643.1 - 0.089 12.2 0.5 0.24 10.7 0.2 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF4537 PF15057.1 ESL08644.1 - 0.069 12.9 0.4 0.08 12.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DUF1977 PF09320.6 ESL08645.1 - 0.13 12.5 0.3 0.15 12.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1977) DUF2462 PF09495.5 ESL08645.1 - 5.5 7.7 16.9 0.047 14.4 2.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2462) RrnaAD PF00398.15 ESL08646.1 - 1.1e-29 103.3 0.0 4.1e-29 101.3 0.0 1.7 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.7 ESL08646.1 - 0.00055 20.3 0.0 0.0019 18.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESL08646.1 - 0.11 12.1 0.0 0.32 10.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain CN_hydrolase PF00795.17 ESL08647.1 - 4.1e-30 104.5 0.0 5.7e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Lipase_3 PF01764.20 ESL08648.1 - 2.4e-05 23.9 0.0 5.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.15 ESL08648.1 - 0.0064 16.7 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 ESL08648.1 - 0.0067 16.0 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.15 ESL08648.1 - 0.014 14.9 0.0 0.34 10.4 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold YjeF_N PF03853.10 ESL08648.1 - 0.028 14.0 0.0 0.066 12.8 0.0 1.6 1 0 0 1 1 1 0 YjeF-related protein N-terminus TetR_C_2 PF08361.6 ESL08648.1 - 0.069 13.0 0.2 0.23 11.3 0.1 1.8 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region DUF4379 PF14311.1 ESL08650.1 - 2e-14 53.1 0.4 3.2e-14 52.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) HypA PF01155.14 ESL08650.1 - 0.14 11.8 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zinc_ribbon_5 PF13719.1 ESL08650.1 - 0.69 9.5 2.7 3.5 7.2 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain eIF-5_eIF-2B PF01873.12 ESL08652.1 - 2.6e-32 111.1 0.2 2.6e-32 111.1 0.1 1.6 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.13 ESL08652.1 - 0.00035 20.4 0.0 0.00093 19.0 0.0 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon DUF3133 PF11331.3 ESL08652.1 - 0.029 13.9 2.2 0.082 12.4 1.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3133) zf-CHY PF05495.7 ESL08652.1 - 0.038 14.1 0.3 0.091 12.9 0.2 1.6 1 0 0 1 1 1 0 CHY zinc finger RPA_C PF08784.6 ESL08652.1 - 0.07 13.5 0.1 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 Replication protein A C terminal SelB-wing_1 PF09105.5 ESL08652.1 - 0.084 12.5 1.0 3.8 7.2 0.0 2.6 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Alpha_GJ PF03229.8 ESL08652.1 - 0.1 12.9 5.9 0.1 12.9 3.0 1.7 2 0 0 2 2 2 0 Alphavirus glycoprotein J K_channel_TID PF07941.6 ESL08652.1 - 0.4 10.9 7.7 0.75 10.0 5.4 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain GAS PF13851.1 ESL08653.1 - 3.6e-67 225.4 32.3 3.6e-67 225.4 22.4 3.1 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding NYD-SP28 PF14772.1 ESL08653.1 - 0.22 11.6 0.1 0.22 11.6 0.1 5.8 2 1 2 5 5 5 0 Sperm tail PSD5 PF07637.6 ESL08653.1 - 3.1 7.9 6.6 3.3 7.8 1.0 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1595) ApoO PF09769.4 ESL08653.1 - 8.3 6.0 9.5 5.2 6.7 0.8 3.3 2 1 1 3 3 3 0 Apolipoprotein O Pkinase PF00069.20 ESL08655.1 - 9.2e-59 198.6 0.0 1.1e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08655.1 - 2.3e-28 98.9 0.0 2.9e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08655.1 - 2.7e-05 23.2 0.0 9.6e-05 21.4 0.0 1.7 1 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESL08655.1 - 5.6e-05 22.9 0.1 0.0013 18.4 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESL08655.1 - 0.0065 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase HCV_NS5a PF01506.14 ESL08655.1 - 0.018 14.6 1.0 0.04 13.5 0.7 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a protein membrane anchor Pox_ser-thr_kin PF05445.6 ESL08655.1 - 0.27 9.9 0.0 0.41 9.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase zf-CCCH PF00642.19 ESL08656.1 - 0.035 13.7 4.0 0.035 13.7 2.8 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_L3 PF00297.17 ESL08657.1 - 9.1e-101 336.6 9.5 1.1e-100 336.3 6.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 B9-C2 PF07162.6 ESL08658.1 - 4.1e-39 134.0 0.0 5.3e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein HR1 PF02185.11 ESL08659.1 - 0.031 14.0 3.1 0.15 11.8 0.4 2.7 2 0 0 2 2 2 0 Hr1 repeat Atg14 PF10186.4 ESL08659.1 - 0.057 12.3 3.5 0.027 13.4 0.6 1.7 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 CCDC155 PF14662.1 ESL08659.1 - 0.23 11.0 7.1 2.5 7.6 0.4 2.9 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 Sec2p PF06428.6 ESL08659.1 - 0.35 10.7 6.2 0.29 10.9 0.3 3.2 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Pkinase PF00069.20 ESL08660.1 - 3.3e-32 111.6 0.0 4.3e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08660.1 - 1.2e-15 57.2 0.0 1.6e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08660.1 - 9.4e-06 24.7 0.0 1.2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 ESL08660.1 - 0.014 14.2 0.1 0.028 13.2 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 RIO1 PF01163.17 ESL08660.1 - 0.015 14.6 0.0 0.049 12.9 0.0 1.7 2 0 0 2 2 2 0 RIO1 family cNMP_binding PF00027.24 ESL08661.1 - 1e-30 105.3 0.1 2.5e-17 62.4 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_4 PF12799.2 ESL08661.1 - 0.00063 19.3 2.9 0.033 13.8 0.5 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL08661.1 - 0.0059 16.5 1.0 1.3 9.3 0.0 3.0 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.28 ESL08661.1 - 0.13 12.4 1.1 12 6.3 0.1 3.0 2 1 0 2 2 2 0 Leucine Rich Repeat WD40 PF00400.27 ESL08662.1 - 0.0046 16.7 0.7 0.15 12.0 0.0 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat CytochromB561_N PF09786.4 ESL08664.1 - 4.6e-07 28.6 0.0 3.1e-05 22.6 0.0 2.1 1 1 1 2 2 2 2 Cytochrome B561, N terminal FGE-sulfatase PF03781.11 ESL08665.1 - 1e-19 70.9 2.4 2.6e-19 69.6 1.7 1.7 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.2 ESL08665.1 - 5.7e-11 42.8 0.1 1.1e-10 41.9 0.1 1.5 1 0 0 1 1 1 1 DinB superfamily Methyltransf_25 PF13649.1 ESL08665.1 - 1.1e-09 38.5 0.0 4.6e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL08665.1 - 6.9e-06 26.6 0.0 2e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL08665.1 - 0.00016 21.4 0.0 0.00058 19.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL08665.1 - 0.033 14.6 0.0 0.18 12.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ESL08665.1 - 0.23 11.0 0.0 1.6 8.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain FAM176 PF14851.1 ESL08666.1 - 0.035 13.7 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 FAM176 family DUF1109 PF06532.6 ESL08666.1 - 0.066 12.6 0.0 0.093 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1109) DUF1049 PF06305.6 ESL08666.1 - 0.14 11.6 0.1 0.28 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) TRAP_alpha PF03896.11 ESL08667.1 - 0.017 14.1 0.0 0.017 14.1 0.0 6.2 5 1 0 5 5 5 0 Translocon-associated protein (TRAP), alpha subunit SAPS PF04499.10 ESL08667.1 - 0.11 11.1 0.0 0.11 11.1 0.0 3.4 2 2 0 2 2 2 0 SIT4 phosphatase-associated protein WD40 PF00400.27 ESL08669.1 - 3.2e-07 29.9 0.2 6e-06 25.9 0.0 3.1 2 0 0 2 2 2 1 WD domain, G-beta repeat Apc3 PF12895.2 ESL08669.1 - 0.088 12.9 0.2 0.41 10.8 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RraB PF06877.6 ESL08670.1 - 0.12 13.0 9.0 2.1 9.0 2.1 3.4 3 0 0 3 3 3 0 Regulator of ribonuclease activity B MFS_1 PF07690.11 ESL08671.1 - 2e-23 82.6 56.8 5.8e-20 71.3 19.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PseudoU_synth_2 PF00849.17 ESL08672.1 - 3.6e-44 150.4 0.0 5e-44 150.0 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Bap31 PF05529.7 ESL08673.1 - 3.1e-08 33.3 0.5 3.6e-08 33.0 0.4 1.1 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DUF4181 PF13789.1 ESL08673.1 - 0.88 9.5 4.7 8 6.4 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4181) RRM_1 PF00076.17 ESL08674.1 - 5.4e-42 141.2 4.1 2.6e-16 59.0 0.0 6.5 5 2 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL08674.1 - 3.2e-41 139.1 0.2 4.5e-15 55.3 0.0 5.7 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08674.1 - 6.9e-24 83.4 0.1 2.2e-09 37.0 0.0 5.3 6 0 0 6 6 6 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESL08674.1 - 0.066 12.9 1.2 2.1 8.1 0.0 3.9 4 1 0 4 4 4 0 Limkain b1 ODC_AZ PF02100.12 ESL08674.1 - 0.11 12.0 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Ornithine decarboxylase antizyme Ribonuc_red_lgC PF02867.10 ESL08675.1 - 3.6e-210 699.0 0.0 4.4e-210 698.8 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 ESL08675.1 - 3.6e-22 77.9 0.0 9.7e-22 76.5 0.0 1.8 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 ESL08675.1 - 1.3e-12 47.9 0.1 7.2e-12 45.5 0.0 2.3 2 0 0 2 2 2 1 ATP cone domain MAM33 PF02330.11 ESL08676.1 - 1.2e-11 44.8 0.4 1.6e-11 44.3 0.3 1.6 1 1 0 1 1 1 1 Mitochondrial glycoprotein CRAL_TRIO PF00650.15 ESL08678.1 - 2.5e-23 82.3 0.0 3.5e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CAP_GLY PF01302.20 ESL08678.1 - 7.1e-14 51.2 0.1 1.3e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain Bromodomain PF00439.20 ESL08679.1 - 7.1e-11 41.8 0.0 1.3e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Bromodomain zf-CW PF07496.10 ESL08679.1 - 0.046 13.4 7.7 0.11 12.2 5.3 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger DUF543 PF04418.7 ESL08680.1 - 3e-22 78.3 0.0 3.5e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) TctA PF01970.11 ESL08680.1 - 0.044 12.1 0.0 0.49 8.7 0.0 1.9 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctA family JAB PF01398.16 ESL08681.1 - 1.3e-22 79.6 0.0 2.5e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESL08681.1 - 1.4e-05 24.5 0.0 3.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain EMP70 PF02990.11 ESL08682.1 - 9.6e-137 456.5 14.6 1.2e-136 456.2 10.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 PH PF00169.24 ESL08683.1 - 0.0011 19.1 0.1 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 PH domain DUF303 PF03629.13 ESL08683.1 - 0.0072 15.5 0.0 0.0096 15.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF303) zf-HC5HC2H PF13771.1 ESL08684.1 - 4.9e-06 26.5 7.8 4.9e-06 26.5 5.4 2.6 3 1 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESL08684.1 - 0.012 15.5 10.9 0.012 15.5 7.5 2.3 2 0 0 2 2 2 0 PHD-zinc-finger like domain EF-hand_8 PF13833.1 ESL08685.1 - 0.0052 16.3 0.0 0.022 14.3 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain pair EMP24_GP25L PF01105.19 ESL08685.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD CCDC155 PF14662.1 ESL08685.1 - 0.1 12.1 9.7 0.19 11.3 6.7 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 IncA PF04156.9 ESL08685.1 - 1.9 8.0 7.9 3.5 7.1 5.5 1.4 1 0 0 1 1 1 0 IncA protein DUF2570 PF10828.3 ESL08685.1 - 2.1 7.9 5.2 0.8 9.3 1.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) CTDII PF01556.13 ESL08686.1 - 1.8e-22 78.9 0.0 2e-17 62.8 0.0 2.4 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 ESL08686.1 - 3.7e-16 58.5 0.3 6.1e-16 57.9 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain LRR_4 PF12799.2 ESL08688.1 - 6.9e-18 63.8 10.2 2.7e-05 23.6 0.0 4.5 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESL08688.1 - 2.2e-07 30.5 1.8 1.2e-05 24.9 0.3 2.6 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.1 ESL08688.1 - 3.2e-07 29.9 14.5 0.00085 19.0 0.7 4.0 2 1 2 4 4 4 3 Leucine rich repeat Tup_N PF08581.5 ESL08688.1 - 1.3e-06 28.4 7.6 0.0016 18.6 1.1 2.9 1 1 1 2 2 2 2 Tup N-terminal LRR_7 PF13504.1 ESL08688.1 - 1.6e-05 24.3 6.1 8.2 7.1 0.0 7.1 7 0 0 7 7 6 0 Leucine rich repeat LRR_1 PF00560.28 ESL08688.1 - 3.3e-05 23.3 11.2 8 6.9 0.1 7.2 6 1 1 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.1 ESL08688.1 - 0.00012 21.7 9.1 10 6.5 0.2 6.3 5 1 3 8 8 5 0 Leucine Rich repeat BBP1_C PF15272.1 ESL08688.1 - 0.0083 15.7 4.1 0.018 14.6 2.8 1.5 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal DUF2951 PF11166.3 ESL08688.1 - 0.049 13.4 5.8 0.036 13.8 2.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) ALIX_LYPXL_bnd PF13949.1 ESL08688.1 - 0.052 12.5 9.6 0.091 11.7 6.7 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV IncA PF04156.9 ESL08688.1 - 0.067 12.7 14.8 0.32 10.5 10.3 2.1 1 1 0 1 1 1 0 IncA protein DUF641 PF04859.7 ESL08688.1 - 0.11 12.2 4.8 0.39 10.4 3.3 2.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) LRR_3 PF07725.7 ESL08688.1 - 0.42 10.4 2.1 0.92 9.3 0.1 2.7 3 0 0 3 3 2 0 Leucine Rich Repeat Sec2p PF06428.6 ESL08688.1 - 0.52 10.1 7.8 0.14 12.0 1.3 2.7 1 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p Prominin PF05478.6 ESL08688.1 - 0.78 7.2 4.0 1.1 6.6 2.8 1.1 1 0 0 1 1 1 0 Prominin Rootletin PF15035.1 ESL08688.1 - 1.4 8.8 15.8 28 4.6 9.8 2.7 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.8 ESL08688.1 - 1.5 9.2 5.7 1.5 9.2 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ADIP PF11559.3 ESL08688.1 - 1.5 8.6 17.4 0.45 10.4 6.2 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.6 ESL08688.1 - 2 7.0 7.0 3.1 6.3 4.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Atg14 PF10186.4 ESL08688.1 - 3.1 6.6 10.1 5.7 5.7 7.0 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4407 PF14362.1 ESL08688.1 - 3.4 6.5 9.7 33 3.3 6.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.3 ESL08688.1 - 3.5 7.4 14.0 7.6 6.4 6.4 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TMPIT PF07851.8 ESL08688.1 - 4.7 6.1 4.8 23 3.9 2.1 2.0 1 1 1 2 2 2 0 TMPIT-like protein EMP24_GP25L PF01105.19 ESL08688.1 - 5 6.7 6.1 10 5.7 0.4 2.3 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD V_ATPase_I PF01496.14 ESL08688.1 - 5.6 4.6 5.0 8.1 4.1 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin PF00804.20 ESL08688.1 - 7.1 6.8 9.8 25 5.1 5.7 2.5 1 1 1 2 2 2 0 Syntaxin CENP-H PF05837.7 ESL08688.1 - 7.9 6.7 12.3 2 8.6 3.7 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) SpoV PF08183.6 ESL08690.1 - 8.3e-05 22.2 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 Stage V sporulation protein family TIP49 PF06068.8 ESL08691.1 - 1.2e-179 597.2 4.3 1.2e-179 597.2 3.0 1.5 2 0 0 2 2 2 1 TIP49 C-terminus AAA PF00004.24 ESL08691.1 - 1.2e-08 35.2 3.3 5.7e-06 26.5 0.1 3.2 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL08691.1 - 9.6e-07 29.0 0.4 0.085 12.9 0.0 3.3 3 1 0 3 3 3 2 AAA domain RuvB_N PF05496.7 ESL08691.1 - 2.7e-06 26.5 1.2 0.002 17.2 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 ESL08691.1 - 3.9e-06 25.9 0.1 8.2e-06 24.8 0.1 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_5 PF07728.9 ESL08691.1 - 6e-06 26.0 0.1 0.0014 18.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL08691.1 - 3.8e-05 23.7 0.3 0.00094 19.2 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 ESL08691.1 - 0.00011 21.9 0.8 0.00026 20.6 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_25 PF13481.1 ESL08691.1 - 0.00036 20.0 0.0 0.00084 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESL08691.1 - 0.00037 19.7 0.8 0.0095 15.1 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESL08691.1 - 0.006 16.0 0.0 2.1 7.8 0.1 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain KaiC PF06745.8 ESL08691.1 - 0.0072 15.4 0.1 0.014 14.4 0.1 1.6 1 0 0 1 1 1 1 KaiC UPF0079 PF02367.12 ESL08691.1 - 0.0099 15.5 0.2 0.024 14.2 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 ESL08691.1 - 0.013 14.9 0.5 1.1 8.6 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.12 ESL08691.1 - 0.015 14.7 0.3 0.031 13.7 0.2 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 ESL08691.1 - 0.022 14.4 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.7 ESL08691.1 - 0.025 13.6 0.5 0.061 12.4 0.4 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.1 ESL08691.1 - 0.03 14.2 0.2 0.063 13.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESL08691.1 - 0.033 13.1 0.0 0.055 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) 2Fe-2S_Ferredox PF11591.3 ESL08692.1 - 0.028 14.0 0.4 0.19 11.4 0.1 2.6 2 0 0 2 2 2 0 Ferredoxin chloroplastic transit peptide PC_rep PF01851.17 ESL08692.1 - 0.079 13.2 15.3 29 5.1 0.0 6.3 6 0 0 6 6 6 0 Proteasome/cyclosome repeat Dapper PF15268.1 ESL08692.1 - 0.32 9.7 0.5 0.49 9.1 0.3 1.1 1 0 0 1 1 1 0 Dapper F-box PF00646.28 ESL08693.1 - 0.0081 15.7 0.2 0.018 14.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain GPCR_chapero_1 PF11904.3 ESL08693.1 - 0.094 11.8 2.8 4.7 6.2 0.0 2.2 2 0 0 2 2 2 0 GPCR-chaperone APG5 PF04106.7 ESL08694.1 - 0.078 12.4 0.0 4 6.8 0.0 2.6 3 0 0 3 3 3 0 Autophagy protein Apg5 FUSC_2 PF13515.1 ESL08695.1 - 0.0055 16.6 15.1 0.0055 16.6 10.5 2.8 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ETS_PEA3_N PF04621.8 ESL08698.1 - 0.0023 17.2 0.2 0.0028 16.9 0.1 1.1 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain RRM_6 PF14259.1 ESL08698.1 - 0.0045 16.9 0.0 0.095 12.6 0.0 2.4 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Glyco_transf_11 PF01531.11 ESL08699.1 - 6.5e-15 54.8 0.5 3e-07 29.7 0.0 3.0 3 0 0 3 3 3 3 Glycosyl transferase family 11 RabGAP-TBC PF00566.13 ESL08700.1 - 7.2e-32 110.5 0.0 9.2e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pex24p PF06398.6 ESL08700.1 - 6.4e-12 44.9 5.1 6.4e-12 44.9 3.5 2.0 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin FA_desaturase PF00487.19 ESL08701.1 - 2.2e-25 89.5 34.0 2.2e-25 89.5 23.6 1.6 2 0 0 2 2 2 1 Fatty acid desaturase EMP24_GP25L PF01105.19 ESL08702.1 - 9.3e-41 139.5 0.0 1.1e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EF1_GNE PF00736.14 ESL08702.1 - 0.027 14.1 0.0 8 6.2 0.0 2.4 2 1 0 2 2 2 0 EF-1 guanine nucleotide exchange domain Fumarate_red_D PF02313.12 ESL08702.1 - 0.18 11.7 2.6 1.7 8.5 0.1 2.2 2 0 0 2 2 2 0 Fumarate reductase subunit D zf-CCCH PF00642.19 ESL08703.1 - 5.3e-09 35.5 11.0 0.0013 18.3 0.0 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) LRV_FeS PF05484.6 ESL08703.1 - 0.5 9.9 7.9 1.9 8.1 0.2 3.3 4 0 0 4 4 4 0 LRV protein FeS4 cluster Fucose_iso_C PF02952.12 ESL08704.1 - 0.021 14.3 0.1 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain BTV_NS2 PF04514.7 ESL08705.1 - 1 8.1 12.9 0.093 11.5 4.5 1.9 2 0 0 2 2 2 0 Bluetongue virus non-structural protein NS2 PEHE PF15275.1 ESL08705.1 - 4.7 7.6 7.5 2.9 8.3 2.2 2.1 2 0 0 2 2 2 0 PEHE domain Tubulin PF00091.20 ESL08706.1 - 1.7e-67 227.4 0.0 2.2e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESL08706.1 - 9.6e-19 67.6 0.3 1.6e-18 66.9 0.2 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 ESL08706.1 - 0.031 13.7 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain PHTB1_N PF14727.1 ESL08707.1 - 3.2e-122 408.4 0.0 4.5e-122 407.9 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.1 ESL08707.1 - 4.1e-49 167.3 0.0 5.5e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus E_Pc_C PF06752.7 ESL08707.1 - 0.025 14.0 0.1 0.072 12.5 0.0 1.8 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Tubulin_3 PF14881.1 ESL08708.1 - 6.8e-05 22.4 0.1 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 ESL08708.1 - 0.0025 17.8 0.0 0.0055 16.7 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain DUF2607 PF10795.4 ESL08708.1 - 0.03 14.1 2.3 0.09 12.6 1.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2607) Spc97_Spc98 PF04130.8 ESL08709.1 - 1.1e-87 294.6 0.0 1.4e-87 294.2 0.0 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family Raptor_N PF14538.1 ESL08711.1 - 0.1 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain AMP-binding PF00501.23 ESL08713.1 - 2.3e-86 289.8 0.0 3e-86 289.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Aa_trans PF01490.13 ESL08714.1 - 1.8e-62 211.1 31.4 2.1e-62 210.9 21.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 ESL08714.1 - 1.7e-08 33.4 14.7 1.7e-08 33.4 10.2 2.1 1 1 1 2 2 2 1 Amino acid permease Trp_Tyr_perm PF03222.8 ESL08714.1 - 2.9e-08 32.9 11.9 2.9e-08 32.9 8.2 2.4 2 1 2 4 4 4 1 Tryptophan/tyrosine permease family DUF2663 PF10864.3 ESL08714.1 - 0.093 12.9 0.0 2.2 8.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) LHC PF00556.15 ESL08714.1 - 4.1 7.3 7.9 6.5 6.6 3.3 3.0 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit ECSIT PF06239.6 ESL08715.1 - 0.2 10.4 0.0 0.36 9.6 0.0 1.3 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway DUF2721 PF11026.3 ESL08716.1 - 0.44 10.1 4.6 7.2 6.2 1.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Telomere_reg-2 PF10193.4 ESL08717.1 - 3.7e-06 27.1 0.2 2.2e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Telomere length regulation protein RTC PF01137.16 ESL08719.1 - 1.6e-51 174.3 0.1 2e-51 173.9 0.1 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 ESL08719.1 - 3.2e-26 91.3 0.1 5.1e-26 90.6 0.1 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain zf-CCHC PF00098.18 ESL08721.1 - 0.03 14.2 8.7 0.55 10.2 0.9 2.9 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 ESL08721.1 - 0.45 10.2 7.3 0.18 11.5 0.6 2.7 2 0 0 2 2 2 0 Zinc knuckle eIF3g PF12353.3 ESL08721.1 - 2.7 7.8 7.3 0.4 10.6 0.2 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G Cyt-b5 PF00173.23 ESL08722.1 - 8.2e-11 41.5 0.0 9.7e-11 41.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PSII_Pbs27 PF13326.1 ESL08722.1 - 0.051 13.5 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 Photosystem II Pbs27 OHCU_decarbox PF09349.5 ESL08722.1 - 0.061 13.6 0.0 0.079 13.2 0.0 1.1 1 0 0 1 1 1 0 OHCU decarboxylase MU117 PF15474.1 ESL08722.1 - 0.099 13.1 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Meiotically up-regulated gene family WD40 PF00400.27 ESL08723.1 - 3.1e-19 68.0 7.5 3.3e-05 23.5 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 ESL08723.1 - 0.0031 15.7 0.4 0.68 7.9 0.0 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 TPR_12 PF13424.1 ESL08724.1 - 0.051 13.5 0.7 0.18 11.7 0.3 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TMF_DNA_bd PF12329.3 ESL08725.1 - 0.0039 16.9 5.2 1.5 8.7 0.0 3.5 3 1 0 3 3 3 2 TATA element modulatory factor 1 DNA binding CENP-R PF06729.7 ESL08725.1 - 0.11 12.1 1.1 0.7 9.5 0.1 2.2 2 0 0 2 2 2 0 Kinetochore component, CENP-R DUF4407 PF14362.1 ESL08725.1 - 0.2 10.5 4.9 0.25 10.2 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlxA PF14282.1 ESL08725.1 - 0.5 10.3 3.0 0.7 9.8 0.9 2.0 1 1 1 2 2 2 0 FlxA-like protein DUF641 PF04859.7 ESL08725.1 - 1.4 8.6 6.5 3.3 7.4 0.8 2.7 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Sec2p PF06428.6 ESL08725.1 - 5.8 6.8 9.4 6.9 6.5 0.4 3.2 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p YbaB_DNA_bd PF02575.11 ESL08726.1 - 3.1e-05 23.7 0.0 6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family Acetyltransf_1 PF00583.19 ESL08727.1 - 0.00019 21.3 0.1 0.0027 17.6 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL08727.1 - 0.00068 19.7 0.0 0.0024 18.0 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL08727.1 - 0.012 15.4 0.0 0.1 12.4 0.0 2.2 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain EF-hand_7 PF13499.1 ESL08729.1 - 1.4e-13 50.7 0.8 2.7e-06 27.3 0.2 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL08729.1 - 1.1e-10 39.9 0.9 0.00013 20.9 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 ESL08729.1 - 1.6e-10 39.9 0.4 0.0022 17.7 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 ESL08729.1 - 8.1e-09 34.4 0.2 0.00027 20.1 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 ESL08729.1 - 1.1e-08 34.5 5.4 0.0012 18.4 0.1 4.1 4 1 1 5 5 5 2 EF-hand domain pair Pterin_4a PF01329.14 ESL08730.1 - 2.5e-29 100.8 0.1 2.8e-29 100.7 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Ribosomal_L7Ae PF01248.21 ESL08731.1 - 3.6e-21 74.4 1.6 5.7e-21 73.8 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 ESL08731.1 - 8.4e-05 22.4 0.1 0.00014 21.7 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF1840 PF08895.6 ESL08732.1 - 0.12 12.3 0.0 0.74 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) LRR_6 PF13516.1 ESL08735.1 - 7.4e-24 81.1 35.7 0.0045 16.9 0.4 12.0 12 0 0 12 12 12 7 Leucine Rich repeat LRR_1 PF00560.28 ESL08735.1 - 7.9e-08 31.3 23.5 0.14 12.3 0.0 9.5 9 2 0 9 9 9 2 Leucine Rich Repeat LRR_4 PF12799.2 ESL08735.1 - 1e-07 31.4 22.1 0.0082 15.7 0.9 6.7 3 2 5 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL08735.1 - 3e-05 23.7 25.5 0.017 14.8 2.9 5.9 4 2 2 6 6 6 4 Leucine rich repeat LRR_7 PF13504.1 ESL08735.1 - 0.031 14.4 19.9 4.4 7.9 0.2 8.1 7 0 0 7 7 7 0 Leucine rich repeat DUF1664 PF07889.7 ESL08735.1 - 0.39 10.5 11.3 0.47 10.2 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Med9 PF07544.8 ESL08735.1 - 1 9.1 9.7 1.1 9.0 1.5 3.2 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 V_ATPase_I PF01496.14 ESL08735.1 - 8.1 4.1 8.5 14 3.3 5.9 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PSP1 PF04468.7 ESL08736.1 - 1.5e-22 79.3 0.6 1.5e-22 79.3 0.4 1.9 2 0 0 2 2 2 1 PSP1 C-terminal conserved region Pyrophosphatase PF00719.14 ESL08737.1 - 2.9e-49 166.5 0.0 4.5e-49 165.8 0.0 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase EF-hand_7 PF13499.1 ESL08737.1 - 0.0091 16.1 0.3 0.03 14.4 0.3 1.9 2 1 0 2 2 2 1 EF-hand domain pair RRM_1 PF00076.17 ESL08738.1 - 7.7e-27 92.7 0.2 3.7e-16 58.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL08738.1 - 2.5e-22 78.6 0.3 3.4e-13 49.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08738.1 - 1.4e-07 31.2 0.3 0.00023 20.9 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 ESL08738.1 - 0.0018 17.9 0.0 0.29 10.8 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 ESL08738.1 - 0.065 13.1 0.1 0.68 9.9 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) PLRV_ORF5 PF01690.12 ESL08738.1 - 0.15 11.1 7.8 1.3 8.0 0.0 2.9 3 0 0 3 3 3 0 Potato leaf roll virus readthrough protein GTP_EFTU_D2 PF03144.20 ESL08738.1 - 0.65 10.1 4.7 12 6.0 0.7 3.0 3 0 0 3 3 3 0 Elongation factor Tu domain 2 Pkinase PF00069.20 ESL08739.1 - 2.2e-55 187.6 0.0 2.6e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08739.1 - 9.5e-17 60.9 0.0 1.4e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL08739.1 - 5.6e-08 32.8 0.0 0.00017 21.4 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESL08739.1 - 0.034 13.7 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_L22e PF01776.12 ESL08740.1 - 9.3e-38 128.6 5.3 1.1e-37 128.4 3.7 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Flavoprotein PF02441.14 ESL08741.1 - 5.3e-41 139.3 0.5 7.3e-41 138.8 0.3 1.2 1 0 0 1 1 1 1 Flavoprotein Elf1 PF05129.8 ESL08742.1 - 1.1e-21 76.2 0.1 1.5e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.1 ESL08742.1 - 0.058 13.0 1.9 0.064 12.9 0.5 1.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESL08742.1 - 0.063 12.8 1.3 0.12 11.9 0.7 1.7 1 1 1 2 2 2 0 zinc-ribbon domain FdhE PF04216.7 ESL08742.1 - 0.098 12.3 1.3 0.3 10.7 0.4 1.8 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation CbiC PF02570.10 ESL08742.1 - 0.11 11.9 0.0 0.56 9.5 0.0 1.8 2 0 0 2 2 2 0 Precorrin-8X methylmutase Zn_Tnp_IS1 PF03811.8 ESL08742.1 - 0.13 11.7 1.9 0.26 10.7 1.3 1.5 1 0 0 1 1 1 0 InsA N-terminal domain Exo_endo_phos PF03372.18 ESL08743.1 - 1.7e-16 60.9 0.1 2.7e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.22 ESL08743.1 - 1.2e-10 41.2 0.0 2.3e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain ASRT PF07100.6 ESL08743.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer DGF-1_5 PF11038.3 ESL08744.1 - 4.8e-71 239.2 13.9 7.7e-71 238.5 9.6 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESL08744.1 - 4.2e-22 77.8 0.2 1.1e-21 76.4 0.1 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4227 PF14004.1 ESL08744.1 - 0.005 16.6 0.0 0.016 15.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4227) SHR3_chaperone PF08229.6 ESL08744.1 - 0.027 13.4 0.4 0.051 12.5 0.3 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 APG6 PF04111.7 ESL08745.1 - 0.041 12.9 1.1 0.068 12.2 0.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 ESL08745.1 - 0.57 9.7 4.3 1 8.9 3.0 1.3 1 0 0 1 1 1 0 IncA protein FdhE PF04216.7 ESL08747.1 - 0.022 14.4 0.9 0.046 13.4 0.6 1.5 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Ldh_1_C PF02866.13 ESL08748.1 - 6.2e-16 58.6 0.0 1.6e-07 31.2 0.0 2.1 2 0 0 2 2 2 2 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 ESL08748.1 - 1.1e-11 44.6 0.0 2.4e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain WD40 PF00400.27 ESL08749.1 - 4.5e-16 58.0 6.8 1.6e-06 27.7 1.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.3 ESL08749.1 - 0.15 10.1 0.0 0.22 9.6 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Apc4_WD40 PF12894.2 ESL08750.1 - 0.00016 21.0 0.2 0.0063 15.9 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain NTPase_1 PF03266.10 ESL08750.1 - 0.024 14.3 0.0 1.4 8.5 0.0 2.6 2 0 0 2 2 2 0 NTPase CH PF00307.26 ESL08751.1 - 0.00059 19.8 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain KfrA_N PF11740.3 ESL08751.1 - 0.0076 16.6 8.8 0.0076 16.6 6.1 7.4 6 1 2 8 8 8 2 Plasmid replication region DNA-binding N-term DUF2785 PF10978.3 ESL08751.1 - 0.0095 15.4 0.6 0.026 13.9 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2785) CAMSAP_CH PF11971.3 ESL08751.1 - 0.023 14.3 0.0 0.092 12.4 0.0 2.0 2 0 0 2 2 2 0 CAMSAP CH domain Reo_sigmaC PF04582.7 ESL08751.1 - 0.73 8.9 9.7 0.53 9.4 2.9 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Plus-3 PF03126.13 ESL08752.1 - 5.6e-12 45.6 0.1 1.2e-11 44.6 0.1 1.6 1 1 0 1 1 1 1 Plus-3 domain zf-C3HC4_3 PF13920.1 ESL08752.1 - 1.1e-08 34.6 16.8 2e-08 33.7 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL08752.1 - 0.01 15.8 18.4 0.026 14.5 12.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.4 ESL08752.1 - 0.41 10.8 11.7 1 9.5 8.1 1.7 1 1 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 LRR_6 PF13516.1 ESL08753.1 - 3.2e-14 51.3 0.1 0.011 15.6 0.0 5.4 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.2 ESL08753.1 - 5.7e-08 32.1 0.0 0.0021 17.6 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL08753.1 - 6.8e-06 25.4 0.2 9.3 6.7 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.1 ESL08753.1 - 0.00077 19.1 0.3 0.064 13.0 0.2 3.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 ESL08753.1 - 0.0028 17.5 1.0 34 5.2 0.0 4.8 4 0 0 4 4 4 0 Leucine rich repeat Atg14 PF10186.4 ESL08755.1 - 0.0023 16.9 6.6 0.0042 16.0 4.5 1.4 1 1 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 Lipoprotein_7 PF01540.11 ESL08755.1 - 0.0032 16.5 0.2 0.0042 16.2 0.1 1.1 1 0 0 1 1 1 1 Adhesin lipoprotein LMBR1 PF04791.11 ESL08755.1 - 0.1 11.1 2.3 0.11 11.1 1.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Gluconate_2-dh3 PF13618.1 ESL08756.1 - 0.058 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 HMG_box PF00505.14 ESL08756.1 - 0.1 12.8 8.0 1.3 9.3 0.0 3.1 3 0 0 3 3 3 0 HMG (high mobility group) box HMG_box_2 PF09011.5 ESL08756.1 - 0.13 12.6 11.2 0.71 10.2 0.1 3.8 4 0 0 4 4 4 0 HMG-box domain DUF4105 PF13387.1 ESL08756.1 - 0.2 10.8 2.2 0.39 9.8 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) Pribosyltran PF00156.22 ESL08758.1 - 2.3e-11 43.4 0.0 3.8e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF2423 PF10338.4 ESL08758.1 - 0.012 15.6 2.7 0.42 10.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2423) Ribosomal_L28e PF01778.12 ESL08761.1 - 2.4e-21 76.3 2.2 2.4e-21 76.3 1.5 1.3 1 1 0 1 1 1 1 Ribosomal L28e protein family 2-ph_phosp PF04029.9 ESL08761.1 - 0.11 11.4 0.6 0.14 11.0 0.4 1.2 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase Myosin_N PF02736.14 ESL08761.1 - 0.3 10.7 2.1 0.56 9.9 1.4 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain DOCK-C2 PF14429.1 ESL08762.1 - 1.1e-31 109.8 0.0 2.1e-31 108.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF647 PF04884.9 ESL08763.1 - 8.8e-24 84.0 4.3 1.3e-23 83.4 3.0 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis CAP_N PF01213.14 ESL08764.1 - 0.23 10.7 2.2 0.28 10.4 1.5 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF1786 PF08735.5 ESL08765.1 - 0.018 14.2 0.1 0.021 13.9 0.1 1.1 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) PIF1 PF05970.9 ESL08766.1 - 1.3e-36 126.3 0.5 2e-30 105.9 0.1 3.6 2 1 1 3 3 3 3 PIF1-like helicase AAA_30 PF13604.1 ESL08766.1 - 1.7e-17 63.6 0.0 4e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL08766.1 - 2.7e-05 23.8 1.4 0.0001 22.0 0.3 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 ESL08766.1 - 6.4e-05 23.1 0.0 0.00026 21.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL08766.1 - 0.0012 18.5 0.4 0.0056 16.4 0.1 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESL08766.1 - 0.0025 17.0 0.2 0.0048 16.0 0.2 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 ESL08766.1 - 0.0031 16.7 0.1 0.0067 15.6 0.1 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_16 PF13191.1 ESL08766.1 - 0.0045 16.9 0.2 0.025 14.5 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain T2SE PF00437.15 ESL08766.1 - 0.015 14.2 0.0 0.045 12.6 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_11 PF13086.1 ESL08766.1 - 0.016 14.8 0.9 1.3 8.4 0.0 2.9 2 1 1 3 3 3 0 AAA domain Thymidylate_kin PF02223.12 ESL08766.1 - 0.039 13.3 0.1 5.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Thymidylate kinase DUF2075 PF09848.4 ESL08766.1 - 0.046 12.6 0.1 0.099 11.5 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 ESL08766.1 - 0.054 13.1 0.0 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 ESL08766.1 - 0.058 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3584 PF12128.3 ESL08766.1 - 0.075 10.3 0.8 4.5 4.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) ABC_tran PF00005.22 ESL08766.1 - 0.077 13.2 0.1 0.27 11.5 0.0 2.0 2 0 0 2 2 2 0 ABC transporter UPF0079 PF02367.12 ESL08766.1 - 0.096 12.3 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF258 PF03193.11 ESL08766.1 - 0.11 11.6 0.1 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 UvrD-helicase PF00580.16 ESL08766.1 - 0.19 10.9 0.6 0.89 8.7 0.0 2.0 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_24 PF13479.1 ESL08766.1 - 0.22 11.0 0.1 0.7 9.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain Reo_sigmaC PF04582.7 ESL08767.1 - 0.59 9.2 32.9 0.72 8.9 3.5 6.0 3 2 4 7 7 7 0 Reovirus sigma C capsid protein Yippee-Mis18 PF03226.9 ESL08768.1 - 2.9e-15 56.0 0.9 3.5e-15 55.8 0.6 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.3 ESL08768.1 - 0.0064 16.3 0.4 0.0095 15.8 0.2 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I Endonuclease_7 PF02945.10 ESL08768.1 - 0.087 12.5 0.6 0.16 11.6 0.4 1.5 1 1 0 1 1 1 0 Recombination endonuclease VII DUF448 PF04296.8 ESL08768.1 - 0.12 11.9 0.2 11 5.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF448) Mating_C PF12737.2 ESL08769.1 - 0.22 10.3 4.5 0.14 11.0 2.0 1.4 1 1 0 1 1 1 0 C-terminal domain of homeodomain 1 GTP_EFTU PF00009.22 ESL08770.1 - 9.3e-30 103.4 0.3 1.6e-29 102.6 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL08770.1 - 9.8e-08 31.9 0.0 2.3e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESL08770.1 - 1.8e-07 31.1 0.2 5.2e-07 29.6 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 ESL08770.1 - 0.0011 18.4 0.3 1.1 8.7 0.1 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation GTP_EFTU_D4 PF14578.1 ESL08770.1 - 0.0048 16.5 0.0 0.016 14.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 SRPRB PF09439.5 ESL08770.1 - 0.0084 15.3 0.0 0.045 12.9 0.0 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 ESL08770.1 - 0.094 11.9 0.0 0.26 10.5 0.0 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family Evr1_Alr PF04777.8 ESL08771.1 - 3.9e-22 77.9 1.3 7.3e-22 77.0 0.9 1.5 1 0 0 1 1 1 1 Erv1 / Alr family zf-SAP30 PF13866.1 ESL08771.1 - 0.095 12.3 0.4 0.21 11.2 0.1 1.6 1 1 0 1 1 1 0 SAP30 zinc-finger Zn_ribbon_recom PF13408.1 ESL08771.1 - 0.29 11.4 3.1 0.53 10.5 1.4 2.0 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain EF-hand_1 PF00036.27 ESL08772.1 - 1.2e-09 36.7 2.6 0.00046 19.3 0.4 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 ESL08772.1 - 2.1e-09 37.3 0.8 8.9e-08 32.1 0.0 2.6 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESL08772.1 - 3.2e-08 32.8 3.2 0.012 15.4 0.0 4.0 3 1 1 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 ESL08772.1 - 7.2e-07 28.7 0.8 1.8e-05 24.2 0.5 2.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_9 PF14658.1 ESL08772.1 - 0.0067 16.3 0.0 0.02 14.7 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 ESL08772.1 - 0.009 15.3 1.4 0.009 15.3 1.0 2.8 3 1 1 4 4 4 1 EF hand DUF2989 PF11207.3 ESL08772.1 - 0.032 13.6 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) EF-hand_4 PF12763.2 ESL08772.1 - 0.12 12.1 0.5 0.48 10.1 0.2 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Rhodanese PF00581.15 ESL08773.1 - 7.9e-05 22.9 0.0 0.00024 21.4 0.0 1.7 1 1 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.20 ESL08774.1 - 2.1e-38 131.9 0.0 1.7e-13 50.3 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08774.1 - 3.2e-23 82.1 0.0 1.9e-14 53.3 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Phospholamban PF04272.9 ESL08776.1 - 0.19 11.2 0.3 0.46 9.9 0.2 1.6 1 0 0 1 1 1 0 Phospholamban RRM_6 PF14259.1 ESL08778.1 - 0.0003 20.7 0.0 0.00052 19.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL08778.1 - 0.0019 17.7 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Clathrin PF00637.15 ESL08779.1 - 5.9e-108 356.6 18.0 3.5e-26 91.5 0.2 6.2 6 0 0 6 6 6 6 Region in Clathrin and VPS Clathrin_H_link PF13838.1 ESL08779.1 - 1.4e-16 60.1 0.1 6.3e-16 58.0 0.0 2.3 2 0 0 2 2 2 1 Clathrin-H-link TPR_14 PF13428.1 ESL08779.1 - 6.9e-08 32.4 11.1 0.67 10.7 0.0 9.6 12 1 1 13 13 13 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08779.1 - 5.9e-06 25.6 0.1 4.5 7.3 0.0 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08779.1 - 0.0007 19.0 1.6 3.5 7.3 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF3114 PF11311.3 ESL08779.1 - 0.015 14.6 2.2 0.066 12.5 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3114) ATP13 PF12921.2 ESL08779.1 - 0.037 13.3 0.0 0.095 12.0 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial ATPase expression TPR_2 PF07719.12 ESL08779.1 - 0.094 12.6 10.5 24 5.1 0.0 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat zf-CCCH PF00642.19 ESL08780.1 - 0.031 13.9 6.9 0.036 13.7 0.6 2.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_L6e PF01159.14 ESL08782.1 - 1e-34 118.9 0.7 2.2e-34 117.9 0.5 1.5 1 1 0 1 1 1 1 Ribosomal protein L6e KOW PF00467.24 ESL08782.1 - 0.0033 17.0 0.1 0.024 14.3 0.0 2.4 3 0 0 3 3 3 1 KOW motif DUF4230 PF14014.1 ESL08782.1 - 0.24 11.2 3.2 0.092 12.6 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) Rhomboid PF01694.17 ESL08783.1 - 1.6e-08 34.6 6.0 0.00011 22.3 0.2 2.6 3 0 0 3 3 3 2 Rhomboid family DUF3091 PF11291.3 ESL08786.1 - 0.0024 17.7 1.1 0.04 13.8 0.0 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF3091) Peptidase_S46 PF10459.4 ESL08786.1 - 0.042 12.2 6.0 0.049 12.0 4.2 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF1777 PF08648.7 ESL08786.1 - 1.1 8.9 19.8 1.4 8.6 13.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DAGAT PF03982.8 ESL08787.1 - 7.7e-21 74.0 0.0 9.5e-21 73.7 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Mab-21 PF03281.9 ESL08788.1 - 0.038 13.1 0.2 0.25 10.4 0.1 2.0 1 1 1 2 2 2 0 Mab-21 protein tRNA-synt_2b PF00587.20 ESL08789.1 - 1e-42 145.6 0.3 1.8e-42 144.8 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESL08789.1 - 5e-19 68.0 0.0 1.1e-18 66.9 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.16 ESL08789.1 - 6e-13 48.4 0.0 1.3e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.9 ESL08789.1 - 3.7e-11 42.7 0.0 6.6e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain EF-hand_6 PF13405.1 ESL08791.1 - 0.1 12.5 1.3 1.1 9.3 0.6 2.7 2 0 0 2 2 2 0 EF-hand domain Clat_adaptor_s PF01217.15 ESL08792.1 - 1.3e-50 170.8 1.9 1.5e-50 170.6 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DEAD PF00270.24 ESL08795.1 - 3.4e-14 52.6 0.0 4.6e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.1 ESL08795.1 - 0.02 14.0 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit PP2C PF00481.16 ESL08797.1 - 7.5e-75 251.6 0.0 9.2e-75 251.3 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL08797.1 - 0.00062 19.2 0.0 0.0067 15.8 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.20 ESL08798.1 - 2e-62 210.6 0.0 2.7e-62 210.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08798.1 - 1.3e-36 125.9 0.0 1.9e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08798.1 - 4e-10 39.1 0.0 3.5e-08 32.7 0.0 2.1 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 ESL08798.1 - 0.0048 16.6 0.0 0.05 13.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family DNA_primase_lrg PF04104.9 ESL08799.1 - 2.9e-74 249.6 0.0 3.9e-74 249.2 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit DUF218 PF02698.12 ESL08800.1 - 6.2e-05 22.5 0.4 0.00015 21.2 0.0 1.8 3 0 0 3 3 3 1 DUF218 domain RRM_1 PF00076.17 ESL08801.1 - 3.7e-07 29.6 0.0 0.0012 18.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL08801.1 - 6e-05 22.8 0.0 0.00046 19.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL08801.1 - 0.00017 21.4 0.0 0.0027 17.6 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) 2-oxoacid_dh PF00198.18 ESL08802.1 - 6.1e-72 241.6 0.2 8e-72 241.2 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 ESL08802.1 - 1.5e-16 59.7 0.5 3.8e-16 58.4 0.3 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 ESL08802.1 - 4.8e-12 45.3 0.0 1.3e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain Pkinase PF00069.20 ESL08803.1 - 1.2e-55 188.5 0.0 1.6e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08803.1 - 1.4e-33 116.0 0.0 2.6e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08803.1 - 1.3e-08 34.1 0.0 3.1e-08 32.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL08803.1 - 5.6e-06 26.2 0.2 0.12 12.0 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESL08803.1 - 0.0062 15.6 0.0 0.024 13.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family IRK_N PF08466.5 ESL08803.1 - 0.017 15.0 0.1 0.056 13.3 0.1 1.9 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal C1_2 PF03107.11 ESL08803.1 - 0.019 15.0 6.0 0.051 13.7 4.1 1.8 1 0 0 1 1 1 0 C1 domain Seadorna_VP7 PF07387.6 ESL08803.1 - 0.057 12.2 0.0 0.1 11.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 C1_3 PF07649.7 ESL08803.1 - 0.17 11.9 11.3 0.028 14.4 5.0 1.9 2 0 0 2 2 2 0 C1-like domain FYVE_2 PF02318.11 ESL08803.1 - 0.32 10.9 5.9 0.84 9.5 4.1 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger Elf1 PF05129.8 ESL08803.1 - 1.5 8.5 10.6 0.61 9.8 3.8 2.3 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like ZZ PF00569.12 ESL08803.1 - 4.3 6.9 15.1 0.11 12.0 5.5 2.1 2 1 0 2 2 2 0 Zinc finger, ZZ type Dus PF01207.12 ESL08804.1 - 1.4e-48 165.2 0.0 2e-48 164.8 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Ribosomal_L7Ae PF01248.21 ESL08805.1 - 8.3e-25 86.1 0.0 9.4e-25 85.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family EMP24_GP25L PF01105.19 ESL08806.1 - 4.7e-13 49.2 0.0 5.7e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Baculo_PEP_C PF04513.7 ESL08807.1 - 0.32 10.8 7.1 2.6 7.8 0.2 3.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CAP_N PF01213.14 ESL08809.1 - 0.0065 15.7 0.9 0.02 14.2 0.6 1.8 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Tup_N PF08581.5 ESL08809.1 - 0.018 15.2 0.3 0.018 15.2 0.2 3.5 3 1 0 3 3 3 0 Tup N-terminal ALS2CR8 PF15299.1 ESL08809.1 - 0.13 11.8 1.7 0.23 11.0 0.7 1.7 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 WD40 PF00400.27 ESL08811.1 - 0.00032 20.4 0.9 3 7.8 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat Proteasome_A_N PF10584.4 ESL08811.1 - 0.0033 16.6 0.2 7.2 6.0 0.0 3.5 3 0 0 3 3 3 3 Proteasome subunit A N-terminal signature Rab3-GTPase_cat PF13890.1 ESL08812.1 - 2.9e-40 137.3 0.2 5.3e-40 136.4 0.1 1.4 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Nuc_sug_transp PF04142.10 ESL08814.1 - 1.7e-30 105.9 14.9 2e-29 102.4 10.4 2.1 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 ESL08814.1 - 1.3e-09 38.2 27.0 0.0001 22.3 5.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 ESL08814.1 - 0.0027 17.8 19.4 0.019 15.1 3.5 2.4 2 0 0 2 2 2 2 Multidrug resistance efflux transporter UAA PF08449.6 ESL08814.1 - 0.0039 16.1 18.1 0.06 12.2 5.8 2.2 1 1 1 2 2 2 2 UAA transporter family TPT PF03151.11 ESL08814.1 - 0.024 14.2 19.2 0.042 13.4 1.7 2.4 2 1 0 2 2 2 0 Triose-phosphate Transporter family BDV_G PF06208.6 ESL08815.1 - 0.18 10.6 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus G protein Surp PF01805.15 ESL08816.1 - 0.00011 21.8 2.3 0.00011 21.8 1.6 2.3 2 1 0 2 2 2 1 Surp module LRR_4 PF12799.2 ESL08817.1 - 1.4e-11 43.6 11.0 7.1e-07 28.7 0.1 4.0 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESL08817.1 - 5.6e-09 35.7 0.9 4.7e-08 32.8 0.0 2.2 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.1 ESL08817.1 - 3e-08 33.2 9.7 3.2e-07 30.0 1.9 2.9 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESL08817.1 - 9.9e-05 21.8 9.9 0.49 10.6 0.1 5.2 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.1 ESL08817.1 - 0.092 12.8 3.7 6 7.2 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_7 PF13504.1 ESL08817.1 - 0.17 12.2 13.1 7.3 7.2 0.1 5.4 5 0 0 5 5 5 0 Leucine rich repeat Pkinase PF00069.20 ESL08818.1 - 1.8e-27 96.1 0.0 2.3e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08818.1 - 2.5e-07 30.0 0.0 3.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL08818.1 - 0.0042 16.8 0.0 0.0067 16.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL08818.1 - 0.039 13.0 0.0 0.065 12.2 0.0 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Thioredoxin PF00085.15 ESL08819.1 - 5.3e-13 48.5 0.0 6.2e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Sas10 PF09368.5 ESL08820.1 - 1.3e-19 70.1 4.3 1.3e-19 70.1 3.0 2.3 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 ESL08820.1 - 3.3e-18 65.6 0.9 3.3e-18 65.6 0.7 2.3 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Herpes_UL52 PF03121.10 ESL08821.1 - 0.002 17.8 2.0 0.0056 16.3 1.4 1.7 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase TIM PF00121.13 ESL08822.1 - 2.2e-89 298.7 0.9 2.5e-89 298.5 0.7 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase AP_endonuc_2 PF01261.19 ESL08822.1 - 0.0057 15.9 0.2 0.0093 15.2 0.1 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel CbiJ PF02571.9 ESL08822.1 - 0.03 13.6 0.1 0.38 10.0 0.0 2.1 1 1 1 2 2 2 0 Precorrin-6x reductase CbiJ/CobK tify PF06200.9 ESL08822.1 - 0.13 11.5 0.0 0.67 9.2 0.0 2.2 2 0 0 2 2 2 0 tify domain Death PF00531.17 ESL08822.1 - 0.14 11.9 0.1 2.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Death domain Epimerase PF01370.16 ESL08823.1 - 1.1e-56 191.9 0.0 2.2e-56 190.9 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL08823.1 - 5.8e-12 45.0 0.0 3.2e-11 42.6 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 ESL08823.1 - 4.4e-07 28.8 0.6 5.3e-06 25.3 0.0 2.1 1 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 ESL08823.1 - 5.3e-07 28.8 1.6 1e-05 24.6 0.0 2.9 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 ESL08823.1 - 6.2e-05 22.0 0.1 0.00093 18.1 0.0 2.0 1 1 1 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.1 ESL08823.1 - 0.0017 18.4 0.2 0.17 11.8 0.0 3.0 1 1 1 2 2 2 1 NADH(P)-binding IF-2B PF01008.12 ESL08825.1 - 3.5e-36 124.6 0.1 1.6e-35 122.4 0.0 2.0 2 0 0 2 2 2 1 Initiation factor 2 subunit family DUF4515 PF14988.1 ESL08826.1 - 0.023 14.3 48.3 0.016 14.9 6.4 3.4 1 1 1 3 3 3 0 Domain of unknown function (DUF4515) DUF1043 PF06295.7 ESL08826.1 - 0.11 12.1 13.5 0.043 13.4 1.8 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF1043) DUF3508 PF12018.3 ESL08826.1 - 0.53 9.2 19.4 0.23 10.4 8.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3508) Filament PF00038.16 ESL08826.1 - 1.2 8.5 48.5 12 5.2 14.3 2.6 1 1 1 2 2 2 0 Intermediate filament protein Lipoprotein_7 PF01540.11 ESL08826.1 - 2.1 7.3 11.0 1.2 8.0 3.8 2.1 1 1 0 2 2 2 0 Adhesin lipoprotein DUF2580 PF10824.3 ESL08826.1 - 6.8 7.1 12.4 1.4 9.3 0.7 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2580) CKS PF01111.14 ESL08827.1 - 4.6e-37 125.6 1.9 6.2e-37 125.2 1.3 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DUF1965 PF09248.5 ESL08827.1 - 0.054 13.3 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) LRR_4 PF12799.2 ESL08828.1 - 6.8e-07 28.7 4.1 0.00011 21.7 0.1 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL08828.1 - 0.087 12.5 2.5 1.3 8.8 0.1 3.0 3 0 0 3 3 3 0 Leucine rich repeat LsmAD PF06741.8 ESL08830.1 - 1.9e-25 88.7 0.7 5.5e-25 87.2 0.5 1.8 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.1 ESL08830.1 - 4.9e-16 58.4 0.0 8.6e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain SHIPPO-rpt PF07004.7 ESL08831.1 - 5e-20 71.3 46.3 0.015 16.1 1.4 10.4 10 0 0 10 10 10 9 Sperm-tail PG-rich repeat BRCT PF00533.21 ESL08832.1 - 0.0012 19.0 0.0 0.0062 16.6 0.0 2.1 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain DCX PF03607.12 ESL08834.1 - 5.9e-11 41.7 0.1 2.8e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 Doublecortin IncA PF04156.9 ESL08836.1 - 0.0011 18.5 5.0 0.0011 18.5 3.4 3.2 3 0 0 3 3 3 1 IncA protein Tropomyosin_1 PF12718.2 ESL08836.1 - 0.023 14.5 0.9 0.023 14.5 0.6 2.8 3 0 0 3 3 3 0 Tropomyosin like DUF4200 PF13863.1 ESL08836.1 - 2.3 8.1 13.6 0.12 12.3 1.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.7 ESL08836.1 - 3.4 7.4 10.1 5.6 6.7 0.1 4.0 3 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rho_Binding PF08912.6 ESL08836.1 - 7.1 7.0 10.7 3.3 8.0 0.0 3.7 3 1 0 3 3 3 0 Rho Binding DUF1935 PF09149.5 ESL08837.1 - 4.1e-38 129.5 0.2 4.6e-38 129.3 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Med26 PF08711.6 ESL08838.1 - 4.1e-06 26.1 0.3 0.00015 21.1 0.0 2.7 2 0 0 2 2 2 2 TFIIS helical bundle-like domain SPX PF03105.14 ESL08842.1 - 0.025 14.3 1.4 0.03 14.1 1.0 1.2 1 0 0 1 1 1 0 SPX domain CAP_GLY PF01302.20 ESL08843.1 - 4.2e-23 80.8 0.5 6.6e-23 80.1 0.4 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 ESL08843.1 - 7.3e-23 80.6 0.1 1.6e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.18 ESL08843.1 - 0.0027 17.0 0.0 0.044 13.1 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin family malic PF00390.14 ESL08843.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain SNARE PF05739.14 ESL08844.1 - 2.8e-07 30.1 0.4 2.8e-07 30.1 0.3 2.1 3 0 0 3 3 3 1 SNARE domain ODV-E18 PF10717.4 ESL08844.1 - 0.081 12.3 0.4 0.16 11.4 0.3 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Synaptobrevin PF00957.16 ESL08844.1 - 0.47 10.0 5.2 0.88 9.2 3.6 1.6 1 1 0 1 1 1 0 Synaptobrevin Rifin_STEVOR PF02009.11 ESL08844.1 - 1 8.9 4.8 1.6 8.3 3.0 1.5 1 1 0 1 1 1 0 Rifin/stevor family zf-CCHC_4 PF14392.1 ESL08845.1 - 0.011 15.3 1.6 0.025 14.2 1.1 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 ESL08845.1 - 0.13 12.2 0.8 0.25 11.3 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle GP4 PF03010.9 ESL08845.1 - 0.26 10.9 1.5 19 4.8 0.1 2.5 1 1 1 2 2 2 0 GP4 PIG-Y PF15159.1 ESL08846.1 - 7.2e-08 32.5 5.6 9.3e-08 32.1 3.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y GATase PF00117.23 ESL08848.1 - 7.3e-35 120.1 0.0 9.2e-35 119.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESL08848.1 - 5.4e-09 35.8 0.1 2.6e-08 33.5 0.0 1.9 2 1 0 2 2 2 1 Peptidase C26 Lipase_GDSL_2 PF13472.1 ESL08849.1 - 6.1e-09 36.2 0.0 7.4e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ESL08849.1 - 0.0019 18.0 0.0 0.0026 17.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PTH2 PF01981.11 ESL08854.1 - 6.2e-47 158.0 0.2 7.7e-47 157.7 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 cNMP_binding PF00027.24 ESL08856.1 - 3.5e-07 29.9 0.0 2.3e-06 27.3 0.0 2.2 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain DIOX_N PF14226.1 ESL08857.1 - 5e-34 117.3 0.0 6.9e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESL08857.1 - 7.4e-24 83.9 0.0 1.2e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-AN1 PF01428.11 ESL08859.1 - 1.3e-18 66.6 19.5 8.9e-10 38.2 4.4 2.7 2 1 1 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.10 ESL08859.1 - 0.0039 17.3 14.1 0.25 11.5 2.2 2.5 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain FYVE PF01363.16 ESL08859.1 - 4.8 7.1 20.7 11 6.0 8.4 2.6 1 1 1 2 2 2 0 FYVE zinc finger DUF35_N PF12172.3 ESL08859.1 - 8.1 6.4 10.0 26 4.8 0.6 2.9 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) GCV_H PF01597.14 ESL08860.1 - 0.013 15.1 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Glycine cleavage H-protein UPF0506 PF11703.3 ESL08860.1 - 0.014 15.3 0.5 0.014 15.3 0.3 1.6 2 0 0 2 2 2 0 UPF0506 Snf7 PF03357.16 ESL08861.1 - 4.5e-34 117.2 27.0 4.5e-34 117.2 18.7 1.9 1 1 1 2 2 2 1 Snf7 DUF1002 PF06207.6 ESL08861.1 - 0.18 11.1 5.6 0.067 12.5 1.6 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1002) VanY PF02557.12 ESL08861.1 - 0.35 10.7 3.4 0.65 9.8 0.5 2.0 1 1 1 2 2 2 0 D-alanyl-D-alanine carboxypeptidase MRP-L47 PF06984.8 ESL08861.1 - 0.45 10.4 0.1 0.45 10.4 0.1 2.9 3 1 1 4 4 4 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF2072 PF09845.4 ESL08861.1 - 3.2 7.6 7.8 0.27 11.1 0.2 2.4 2 1 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Rgp1 PF08737.5 ESL08862.1 - 4.6e-34 118.2 0.0 2.1e-16 60.0 0.0 2.7 1 1 2 3 3 3 2 Rgp1 Arrestin_C PF02752.17 ESL08862.1 - 0.016 15.2 0.0 0.16 12.0 0.0 2.4 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Peptidase_S8 PF00082.17 ESL08863.1 - 2.3e-24 86.0 0.0 3.1e-23 82.3 0.0 2.1 1 1 0 1 1 1 1 Subtilase family TPR_11 PF13414.1 ESL08864.1 - 2e-17 62.5 1.6 2.8e-10 39.6 0.4 3.4 2 1 1 3 3 3 3 TPR repeat SET PF00856.23 ESL08864.1 - 6.4e-10 39.5 0.0 2.7e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 SET domain TPR_12 PF13424.1 ESL08864.1 - 0.0035 17.2 8.9 1.4 8.9 0.3 4.5 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08864.1 - 0.022 14.6 4.4 14 5.8 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08864.1 - 0.061 12.9 2.0 72 3.2 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Pyr_redox_3 PF13738.1 ESL08864.1 - 0.15 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TFIIS_C PF01096.13 ESL08865.1 - 1.3e-11 43.9 7.4 1.3e-11 43.9 5.2 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) ZF-HD_dimer PF04770.7 ESL08865.1 - 0.041 13.9 3.0 0.041 13.9 2.1 2.8 2 1 1 3 3 3 0 ZF-HD protein dimerisation region DZR PF12773.2 ESL08865.1 - 0.7 9.7 15.9 0.83 9.5 2.8 3.0 2 2 0 2 2 2 0 Double zinc ribbon DUF2296 PF10058.4 ESL08865.1 - 8.8 6.1 12.2 18 5.2 0.1 3.9 4 1 0 4 4 4 0 Predicted integral membrane metal-binding protein (DUF2296) Ribosomal_60s PF00428.14 ESL08866.1 - 0.19 12.1 4.3 0.5 10.7 3.0 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein cNMP_binding PF00027.24 ESL08867.1 - 2.8e-13 49.4 0.0 8.9e-05 22.2 0.0 3.8 3 1 0 3 3 3 3 Cyclic nucleotide-binding domain Solute_trans_a PF03619.11 ESL08868.1 - 5.4e-88 294.8 10.5 6.9e-88 294.5 7.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Prok-RING_2 PF14445.1 ESL08868.1 - 0.014 15.2 0.3 0.032 14.1 0.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 Acyl-CoA_dh_1 PF00441.19 ESL08870.1 - 6.4e-27 94.4 0.2 1.1e-26 93.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESL08870.1 - 4.9e-22 78.6 0.0 8.9e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESL08870.1 - 3.8e-16 58.3 0.1 8.3e-16 57.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESL08870.1 - 3.4e-06 27.3 0.1 6.2e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain zf-C3HC4_2 PF13923.1 ESL08873.1 - 7.2e-09 35.5 8.2 1.7e-08 34.3 5.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL08873.1 - 1.1e-08 34.5 7.2 1.9e-08 33.8 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL08873.1 - 3.6e-08 32.9 8.1 6.9e-08 32.0 5.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL08873.1 - 1.1e-07 31.5 9.2 2.4e-07 30.4 6.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESL08873.1 - 6.3e-06 25.8 8.3 1.2e-05 24.8 5.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESL08873.1 - 0.00011 21.9 8.7 0.00024 20.8 6.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESL08873.1 - 0.00098 18.7 2.8 0.00098 18.7 2.0 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.15 ESL08873.1 - 0.0022 17.4 7.5 0.0049 16.3 5.2 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Prok-RING_4 PF14447.1 ESL08873.1 - 0.026 14.0 5.4 0.042 13.4 1.3 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.9 ESL08873.1 - 0.14 11.6 0.1 0.14 11.6 0.1 1.8 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-rbx1 PF12678.2 ESL08873.1 - 0.24 11.5 5.9 0.85 9.7 4.1 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger zf-RING_4 PF14570.1 ESL08873.1 - 0.85 9.2 6.6 3.1 7.4 4.7 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FYVE PF01363.16 ESL08873.1 - 1.4 8.9 10.9 0.076 12.9 3.4 2.0 2 0 0 2 2 2 0 FYVE zinc finger UreD PF01774.12 ESL08874.1 - 0.088 12.2 1.9 4.6 6.6 0.3 2.5 1 1 1 2 2 2 0 UreD urease accessory protein Peripla_BP_6 PF13458.1 ESL08875.1 - 2.4e-11 43.5 0.2 3.2e-11 43.1 0.2 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Ribophorin_II PF05817.9 ESL08875.1 - 0.11 10.6 0.8 0.14 10.3 0.6 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II PCMT PF01135.14 ESL08876.1 - 4.4e-57 193.0 0.0 5.3e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 ESL08876.1 - 6.7e-10 38.7 0.0 8.6e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL08876.1 - 8.2e-10 39.2 0.0 1.3e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESL08876.1 - 9.1e-07 28.6 0.0 1.3e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL08876.1 - 6.8e-06 26.0 0.0 2.2e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL08876.1 - 9.1e-06 25.4 0.0 1.5e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL08876.1 - 2.1e-05 24.9 0.0 5.1e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 ESL08876.1 - 5e-05 22.4 0.0 6.5e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_24 PF13578.1 ESL08876.1 - 9.3e-05 23.2 0.0 0.00017 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 ESL08876.1 - 0.00035 19.6 0.0 0.00045 19.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.1 ESL08876.1 - 0.0007 19.9 0.0 0.0011 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESL08876.1 - 0.0032 17.4 0.0 0.0078 16.2 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 ESL08876.1 - 0.027 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.13 ESL08876.1 - 0.061 12.4 0.0 0.087 11.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESL08876.1 - 0.09 13.2 0.0 0.28 11.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain PAP_assoc PF03828.14 ESL08877.1 - 5e-13 48.7 0.0 9.6e-13 47.8 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESL08877.1 - 0.00041 20.6 0.1 0.00092 19.4 0.0 1.6 1 1 0 1 1 1 1 Nucleotidyltransferase domain ORC2 PF04084.9 ESL08878.1 - 0.25 10.1 0.0 2.2 7.0 0.0 2.0 2 0 0 2 2 2 0 Origin recognition complex subunit 2 RmuC PF02646.11 ESL08879.1 - 0.034 12.9 0.6 0.049 12.4 0.4 1.2 1 0 0 1 1 1 0 RmuC family DUF1313 PF07011.6 ESL08879.1 - 0.035 13.7 0.1 0.061 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1313) Baculo_LEF-11 PF06385.7 ESL08879.1 - 0.043 13.9 0.9 1.3 9.2 0.0 2.2 1 1 1 2 2 2 0 Baculovirus LEF-11 protein Mer2 PF09074.5 ESL08879.1 - 0.076 12.9 1.5 0.1 12.4 1.0 1.1 1 0 0 1 1 1 0 Mer2 V_ATPase_I PF01496.14 ESL08879.1 - 0.081 10.7 0.2 0.093 10.5 0.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Plasmid_RAQPRD PF09686.5 ESL08879.1 - 0.081 13.0 1.0 0.16 12.1 0.5 1.5 1 1 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) MYCBPAP PF14646.1 ESL08880.1 - 3.1e-06 26.1 0.1 0.011 14.4 0.0 2.4 1 1 0 2 2 2 2 MYCBP-associated protein family PP2C PF00481.16 ESL08881.1 - 8.1e-71 238.3 0.0 9.8e-71 238.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL08881.1 - 0.00035 20.0 0.0 0.00073 19.0 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 ESL08881.1 - 0.0088 15.7 0.0 0.15 11.7 0.0 2.0 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Peptidase_M8 PF01457.11 ESL08882.1 - 7.1e-39 133.5 0.0 8.3e-39 133.2 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESL08882.1 - 0.093 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Matrixin DPM2 PF07297.7 ESL08883.1 - 6.3e-13 48.8 1.3 9.4e-13 48.2 0.9 1.3 1 1 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) NRPS PF08415.5 ESL08883.1 - 0.068 12.9 0.1 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Nonribosomal peptide synthase DUF2189 PF09955.4 ESL08883.1 - 0.088 12.7 0.6 0.11 12.4 0.4 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2189) RF-1 PF00472.15 ESL08885.1 - 1e-11 44.6 2.5 1e-11 44.6 1.7 3.6 3 1 1 4 4 4 1 RF-1 domain GAS PF13851.1 ESL08885.1 - 6.2e-05 22.2 21.3 6.2e-05 22.2 14.7 2.3 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF3037 PF11236.3 ESL08885.1 - 0.29 11.1 3.3 14 5.7 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3037) V_ATPase_I PF01496.14 ESL08885.1 - 3.4 5.3 13.3 0.29 8.9 5.6 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RNase_PH PF01138.16 ESL08886.1 - 1.8e-09 38.0 0.1 4.6e-09 36.6 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESL08886.1 - 0.00011 22.0 0.2 0.00026 20.8 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Ank PF00023.25 ESL08890.1 - 2.3e-12 46.0 0.0 2.6e-08 33.2 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 ESL08890.1 - 9.8e-12 45.0 0.0 1.7e-11 44.2 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESL08890.1 - 2.4e-10 39.6 0.0 2.2e-05 24.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESL08890.1 - 6.5e-09 36.0 0.0 1.2e-06 28.8 0.0 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL08890.1 - 0.0078 16.4 0.0 0.22 11.8 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) HTH_7 PF02796.10 ESL08890.1 - 0.02 14.7 0.0 0.056 13.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Ribosomal_S6 PF01250.12 ESL08890.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S6 Arc_PepC PF06819.6 ESL08890.1 - 0.13 12.1 0.1 0.21 11.5 0.1 1.2 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain Glyco_transf_10 PF00852.14 ESL08891.1 - 1.5e-25 89.5 0.0 3.1e-21 75.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 10 (fucosyltransferase) zf-CCCH PF00642.19 ESL08892.1 - 2.7e-08 33.3 2.5 5e-08 32.4 1.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESL08892.1 - 0.2 11.6 2.8 1.7 8.7 0.3 2.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type WD40 PF00400.27 ESL08893.1 - 3.4e-33 112.3 12.4 4.9e-10 38.9 0.3 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Prp19 PF08606.6 ESL08894.1 - 0.0003 20.4 9.2 0.00055 19.6 0.3 2.7 2 0 0 2 2 2 1 Prp19/Pso4-like YqjK PF13997.1 ESL08894.1 - 0.038 14.1 0.1 0.038 14.1 0.1 2.6 3 0 0 3 3 3 0 YqjK-like protein DUF3584 PF12128.3 ESL08894.1 - 0.15 9.3 26.3 0.19 9.0 18.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3678 PF12435.3 ESL08895.1 - 1.7 8.2 7.8 1.2 8.7 2.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) PAM2 PF07145.10 ESL08896.1 - 0.049 13.1 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 Ataxin-2 C-terminal region SET PF00856.23 ESL08897.1 - 8e-11 42.5 0.0 2e-10 41.2 0.0 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.13 ESL08897.1 - 0.00012 21.9 12.1 0.00012 21.9 8.4 2.0 2 0 0 2 2 2 1 MYND finger TPR_14 PF13428.1 ESL08897.1 - 0.48 11.1 0.1 0.48 11.1 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Exo_endo_phos PF03372.18 ESL08899.1 - 1.1e-17 64.7 0.0 1.7e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESL08899.1 - 0.018 14.6 0.0 0.28 10.8 0.0 2.5 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF1193 PF06702.7 ESL08900.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1193) Metallophos PF00149.23 ESL08902.1 - 3.1e-05 23.4 1.3 0.00065 19.1 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase zf-RING_2 PF13639.1 ESL08903.1 - 5.6e-15 54.9 30.4 1.2e-11 44.2 5.9 3.6 3 0 0 3 3 2 2 Ring finger domain zf-rbx1 PF12678.2 ESL08903.1 - 3e-08 33.6 6.4 3e-08 33.6 4.5 3.4 3 0 0 3 3 3 2 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESL08903.1 - 1.5e-06 28.1 6.4 1.5e-06 28.1 4.4 3.6 3 0 0 3 3 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL08903.1 - 9e-06 25.2 3.6 9e-06 25.2 2.5 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL08903.1 - 2.5e-05 23.9 6.5 2.5e-05 23.9 4.5 4.2 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL08903.1 - 0.00035 20.1 5.8 0.00035 20.1 4.0 4.1 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.1 ESL08903.1 - 0.0034 17.3 0.7 0.0034 17.3 0.5 3.2 2 1 1 3 3 1 1 PHD-zinc-finger like domain Nitr_red_bet_C PF14711.1 ESL08903.1 - 0.024 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal zf-RING_UBOX PF13445.1 ESL08903.1 - 0.23 11.2 15.4 0.049 13.3 3.1 2.9 2 0 0 2 2 2 0 RING-type zinc-finger CwfJ_C_1 PF04677.10 ESL08903.1 - 0.3 10.7 3.1 0.2 11.3 0.6 1.8 2 0 0 2 2 1 0 Protein similar to CwfJ C-terminus 1 DUF1360 PF07098.6 ESL08903.1 - 0.34 10.6 0.1 0.34 10.6 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1360) Baculo_RING PF05883.6 ESL08903.1 - 9.2 6.0 8.4 2.3 8.0 0.2 2.5 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain FSH1 PF03959.8 ESL08904.1 - 1.5e-36 125.8 0.0 4e-35 121.1 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase (FSH1) RWD PF05773.17 ESL08904.1 - 1.5e-09 37.7 0.0 2.6e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 RWD domain Abhydrolase_5 PF12695.2 ESL08904.1 - 5.6e-08 32.6 0.0 1.5e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL08904.1 - 3.6e-05 23.7 6.0 0.00015 21.7 0.1 2.9 2 2 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESL08904.1 - 0.0023 17.4 1.2 0.035 13.5 0.2 2.6 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 ESL08904.1 - 0.0097 15.4 0.6 2.1 7.8 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold BNR_3 PF13859.1 ESL08905.1 - 8.5e-05 21.7 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain FANCI_HD2 PF14680.1 ESL08906.1 - 0.061 12.4 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 FANCI helical domain 2 GAD PF02938.9 ESL08910.1 - 0.13 12.4 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 GAD domain DUF3782 PF12644.2 ESL08911.1 - 0.044 13.5 2.6 2.8 7.8 0.4 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF3782) MtrB PF05440.7 ESL08911.1 - 0.21 11.6 1.8 4.5 7.3 0.0 3.5 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF948 PF06103.6 ESL08911.1 - 2.4 8.0 6.3 11 5.9 0.0 4.3 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.7 ESL08911.1 - 4 7.2 16.4 7.4 6.3 0.0 5.3 5 1 0 5 5 5 0 Protein of unknown function (DUF1664) CorA PF01544.13 ESL08911.1 - 6.3 5.7 14.8 0.18 10.8 1.5 3.6 2 2 0 3 3 3 0 CorA-like Mg2+ transporter protein DUF4200 PF13863.1 ESL08912.1 - 1.8e-30 105.4 17.0 1.8e-30 105.4 11.8 4.7 4 1 0 4 4 4 3 Domain of unknown function (DUF4200) PCI PF01399.22 ESL08913.1 - 1.2e-11 44.7 0.8 2.8e-11 43.6 0.1 2.1 2 0 0 2 2 2 1 PCI domain Pkinase PF00069.20 ESL08914.1 - 6.1e-55 186.1 0.0 7.4e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08914.1 - 1.6e-23 83.1 0.0 2.2e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL08914.1 - 4.3e-06 26.6 0.1 0.00038 20.2 0.0 3.0 4 0 0 4 4 4 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESL08914.1 - 0.031 13.8 0.3 0.32 10.5 0.0 2.4 2 1 1 3 3 3 0 Choline/ethanolamine kinase Rhodanese PF00581.15 ESL08915.1 - 7.6e-13 48.7 0.0 0.0038 17.5 0.0 3.6 3 0 0 3 3 3 3 Rhodanese-like domain Lactamase_B PF00753.22 ESL08915.1 - 0.00046 19.9 0.0 0.00095 18.8 0.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily PI3_PI4_kinase PF00454.22 ESL08917.1 - 2.1e-34 119.0 0.1 2.8e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 ESL08917.1 - 1.6e-11 43.4 0.0 2.6e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 FATC domain SynMuv_product PF06047.6 ESL08919.1 - 1.6e-11 43.8 3.3 1.6e-11 43.8 2.3 1.9 2 0 0 2 2 2 1 Ras-induced vulval development antagonist Proteasome PF00227.21 ESL08920.1 - 2.5e-60 203.0 0.0 3.4e-60 202.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESL08920.1 - 9e-15 53.6 0.2 1.4e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DnaJ PF00226.26 ESL08921.1 - 6.8e-20 70.5 0.2 1.1e-19 69.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.6 ESL08921.1 - 0.00024 21.2 0.2 0.00056 20.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) NETI PF14044.1 ESL08921.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 NETI protein Spc7 PF08317.6 ESL08922.1 - 0.23 10.0 8.3 1.5 7.4 4.8 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein IncA PF04156.9 ESL08922.1 - 0.24 10.9 8.8 0.51 9.9 6.1 1.5 1 0 0 1 1 1 0 IncA protein RabGAP-TBC PF00566.13 ESL08923.1 - 0.099 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Rab-GTPase-TBC domain NAD_binding_1 PF00175.16 ESL08924.1 - 2.3e-20 73.1 0.0 3.3e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL08924.1 - 2.6e-20 72.3 0.0 4.3e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESL08924.1 - 0.0001 22.2 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain AAA_17 PF13207.1 ESL08925.1 - 5.3e-06 27.2 0.0 1.5e-05 25.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESL08925.1 - 0.00016 21.5 0.0 0.00053 19.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESL08925.1 - 0.004 16.8 0.0 0.0077 15.9 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase MCM PF00493.18 ESL08926.1 - 3.2e-115 384.4 0.0 4.6e-115 383.9 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESL08926.1 - 3.5e-16 59.7 0.0 7.2e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESL08926.1 - 4e-09 35.9 0.1 2e-07 30.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESL08926.1 - 3e-05 23.5 0.0 0.00031 20.2 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.6 ESL08926.1 - 0.00018 21.1 0.0 0.00044 19.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL08926.1 - 0.0029 17.3 0.1 0.017 14.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Exo_endo_phos PF03372.18 ESL08927.1 - 3.1e-09 37.1 0.0 6.1e-09 36.1 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ogr_Delta PF04606.7 ESL08927.1 - 0.53 9.9 6.1 0.071 12.7 0.5 2.2 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger DnaJ PF00226.26 ESL08929.1 - 1.1e-26 92.3 0.7 1.8e-26 91.6 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESL08929.1 - 7.8e-19 67.3 0.3 3.3e-17 62.1 0.1 2.3 2 0 0 2 2 2 1 DnaJ C terminal domain RRM_1 PF00076.17 ESL08931.1 - 7.2e-06 25.5 0.1 3.2e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YTH PF04146.10 ESL08931.1 - 0.00026 20.6 0.0 0.0017 17.9 0.0 2.0 1 1 0 1 1 1 1 YT521-B-like domain RRM_6 PF14259.1 ESL08931.1 - 0.00033 20.5 0.0 0.0007 19.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Thymidylat_synt PF00303.14 ESL08933.1 - 5e-57 192.9 0.0 5.5e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Sec23_trunk PF04811.10 ESL08934.1 - 2.8e-49 167.6 0.0 3.9e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 ESL08934.1 - 3e-20 72.5 1.3 5.4e-20 71.7 0.9 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 ESL08934.1 - 1.4e-13 50.1 5.4 3.2e-13 49.0 3.7 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger VWA PF00092.23 ESL08934.1 - 0.087 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain TTL PF03133.10 ESL08935.1 - 6.4e-67 225.5 0.0 8.8e-67 225.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ESL08935.1 - 0.011 14.6 0.0 0.059 12.1 0.0 1.9 2 0 0 2 2 2 0 YheC/D like ATP-grasp ADH_zinc_N PF00107.21 ESL08936.1 - 1.8e-20 72.7 0.0 3.4e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESL08936.1 - 4.4e-12 45.7 0.0 1.4e-11 44.1 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 ESL08936.1 - 1.1e-09 39.2 0.0 2.1e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.3 ESL08936.1 - 0.0088 15.2 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) AAA_22 PF13401.1 ESL08937.1 - 0.00014 22.0 0.1 0.001 19.2 0.0 2.4 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESL08937.1 - 0.00061 19.8 1.5 0.001 19.1 0.3 2.1 2 1 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.12 ESL08937.1 - 0.0027 17.5 0.3 0.011 15.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA PF00004.24 ESL08937.1 - 0.0056 16.8 0.0 0.13 12.4 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESL08937.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL08937.1 - 0.014 14.8 0.4 0.71 9.2 0.1 2.5 1 1 0 2 2 2 0 AAA domain AAA_19 PF13245.1 ESL08937.1 - 0.017 14.8 0.1 0.065 12.9 0.0 2.0 1 0 0 1 1 1 0 Part of AAA domain FtsK_SpoIIIE PF01580.13 ESL08937.1 - 0.02 14.3 0.0 0.059 12.8 0.0 1.8 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SE PF00437.15 ESL08937.1 - 0.027 13.3 0.0 0.042 12.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.7 ESL08937.1 - 0.029 14.0 0.0 0.082 12.5 0.0 1.8 1 1 0 1 1 1 0 NACHT domain AAA_10 PF12846.2 ESL08937.1 - 0.061 12.7 0.0 0.11 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 ESL08937.1 - 0.066 13.5 0.0 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 ESL08937.1 - 0.067 12.6 0.0 0.17 11.2 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DEAD PF00270.24 ESL08937.1 - 0.072 12.5 0.0 0.17 11.3 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.1 ESL08937.1 - 0.078 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 ESL08937.1 - 0.1 11.3 0.2 1.1 7.9 0.0 2.1 2 0 0 2 2 2 0 ArgK protein ATP-synt_ab PF00006.20 ESL08937.1 - 0.15 11.5 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_11 PF13086.1 ESL08937.1 - 1.2 8.6 6.0 16 5.0 0.0 3.6 4 0 0 4 4 4 0 AAA domain EF-hand_7 PF13499.1 ESL08939.1 - 7.9e-15 54.7 0.1 8.8e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL08939.1 - 1.1e-10 40.5 0.4 4.3e-05 23.0 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 ESL08939.1 - 1.9e-10 39.2 0.9 0.00023 20.2 0.0 4.8 5 1 0 5 5 5 2 EF hand EF-hand_8 PF13833.1 ESL08939.1 - 2.3e-09 36.7 1.3 1.6e-05 24.4 0.3 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 ESL08939.1 - 0.00023 21.0 0.1 0.07 13.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EFhand_Ca_insen PF08726.5 ESL08939.1 - 0.00085 19.2 0.3 1.3 9.0 0.1 2.4 2 0 0 2 2 2 2 Ca2+ insensitive EF hand EF-hand_5 PF13202.1 ESL08939.1 - 0.083 12.2 0.2 11 5.5 0.0 3.4 3 0 0 3 3 3 0 EF hand DUF3647 PF12363.3 ESL08939.1 - 0.093 12.8 0.1 0.48 10.5 0.0 1.9 2 0 0 2 2 2 0 Phage protein SCF PF02404.10 ESL08939.1 - 0.12 11.4 0.1 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Stem cell factor eIF-5a PF01287.15 ESL08940.1 - 6.7e-27 93.2 0.1 1e-26 92.6 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 ESL08940.1 - 4.7e-05 23.1 0.1 0.00012 21.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain DnaJ PF00226.26 ESL08941.1 - 6.3e-15 54.6 0.0 8.5e-15 54.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.8 ESL08941.1 - 1.6e-05 24.3 9.1 3e-05 23.4 6.3 1.6 1 1 0 1 1 1 1 CSL zinc finger DUF1178 PF06676.6 ESL08941.1 - 0.26 11.5 1.8 0.4 10.8 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) Peptidase_S28 PF05577.7 ESL08942.1 - 1.9e-56 191.5 0.3 3.8e-56 190.4 0.1 1.5 2 0 0 2 2 2 1 Serine carboxypeptidase S28 Clat_adaptor_s PF01217.15 ESL08943.1 - 5.5e-13 48.8 0.1 8.3e-13 48.2 0.1 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.1 ESL08943.1 - 4.2e-05 23.5 0.0 5.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 CaM_bdg_C0 PF10562.4 ESL08943.1 - 0.58 10.0 2.9 9.3 6.2 0.6 2.3 2 0 0 2 2 2 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit adh_short PF00106.20 ESL08944.1 - 1.9e-17 63.6 0.3 3.5e-17 62.8 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL08944.1 - 2.3e-08 33.8 0.3 4.4e-08 32.9 0.2 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESL08944.1 - 7.1e-05 22.3 0.0 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESL08944.1 - 0.00011 22.0 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.12 ESL08944.1 - 0.017 14.0 0.0 0.036 12.9 0.0 1.5 1 0 0 1 1 1 0 RmlD substrate binding domain Ldh_1_N PF00056.18 ESL08945.1 - 2.6e-37 127.7 0.1 5.1e-37 126.8 0.0 1.5 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 ESL08945.1 - 4.3e-28 98.2 0.0 5.8e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain ADP_PFK_GK PF04587.10 ESL08946.1 - 0.075 11.2 1.5 0.083 11.0 0.9 1.2 1 1 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region TT_ORF2 PF02957.10 ESL08946.1 - 6.5 7.4 9.9 7.8 7.2 3.0 2.3 1 1 1 2 2 2 0 TT viral ORF2 DUF4496 PF14908.1 ESL08948.1 - 1.7e-30 105.7 0.0 2.4e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4496) TPR_16 PF13432.1 ESL08949.1 - 0.028 15.0 0.3 0.35 11.5 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DegT_DnrJ_EryC1 PF01041.12 ESL08949.1 - 0.04 12.9 0.1 0.061 12.3 0.0 1.1 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family TPR_2 PF07719.12 ESL08949.1 - 0.064 13.2 0.1 0.28 11.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL08951.1 - 3.2e-12 45.9 5.7 0.00086 18.9 0.0 4.2 3 1 1 4 4 4 4 TPR repeat TPR_12 PF13424.1 ESL08951.1 - 6.9e-09 35.5 7.2 0.11 12.4 0.0 4.9 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.12 ESL08951.1 - 0.00018 21.1 4.4 9.6 6.4 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL08951.1 - 0.1 12.4 1.1 7.2 6.6 0.0 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL08951.1 - 0.32 10.9 11.2 0.35 10.8 0.0 4.7 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL08951.1 - 0.67 9.6 7.5 1.5 8.6 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PI3Ka PF00613.15 ESL08953.1 - 8e-49 165.3 1.1 1.6e-48 164.3 0.7 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 ESL08953.1 - 3.3e-42 144.5 0.0 5.5e-42 143.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 ESL08953.1 - 1e-08 35.0 0.0 2.1e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.13 ESL08953.1 - 2.3e-07 30.7 0.1 7.7e-07 29.0 0.0 1.8 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain GCV_T PF01571.16 ESL08956.1 - 1.7e-61 207.2 0.0 2.2e-61 206.9 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 ESL08956.1 - 1.1e-20 73.4 0.2 1.8e-20 72.7 0.2 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain ArfGap PF01412.13 ESL08957.1 - 0.16 11.7 0.2 0.22 11.3 0.1 1.2 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Rieske PF00355.21 ESL08958.1 - 1.8e-05 24.2 0.0 3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 ESL08958.1 - 0.024 14.3 0.0 0.045 13.4 0.0 1.5 1 1 0 1 1 1 0 Rieske-like [2Fe-2S] domain Laminin_G_1 PF00054.18 ESL08958.1 - 0.079 12.9 0.0 0.87 9.5 0.0 2.2 2 0 0 2 2 2 0 Laminin G domain PEN-2 PF10251.4 ESL08959.1 - 3.4e-06 27.1 4.1 4.7e-06 26.7 2.8 1.4 1 1 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Hpre_diP_synt_I PF07456.6 ESL08960.1 - 0.042 13.7 1.5 0.054 13.3 1.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase component I UT PF03253.9 ESL08964.1 - 0.013 14.4 1.1 0.019 13.8 0.7 1.2 1 0 0 1 1 1 0 Urea transporter Hexapep PF00132.19 ESL08965.1 - 8e-09 34.6 13.9 0.0012 18.2 0.0 4.6 3 1 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) DENN PF02141.16 ESL08966.1 - 3.1e-22 79.2 0.9 4.8e-22 78.5 0.6 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 ESL08966.1 - 0.00031 20.6 0.1 0.00073 19.4 0.1 1.7 1 1 0 1 1 1 1 uDENN domain SPA PF08616.5 ESL08966.1 - 0.003 17.2 0.3 0.0098 15.5 0.1 1.9 2 0 0 2 2 2 1 Stabilization of polarity axis Zein-binding PF04576.10 ESL08967.1 - 0.0053 16.8 0.9 0.0053 16.8 0.6 3.5 1 1 3 4 4 4 1 Zein-binding Orbi_VP5 PF00901.12 ESL08967.1 - 0.013 13.7 9.2 0.018 13.2 6.4 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Filament PF00038.16 ESL08967.1 - 0.021 14.2 13.7 0.03 13.8 9.5 1.2 1 0 0 1 1 1 0 Intermediate filament protein DUF3907 PF13047.1 ESL08967.1 - 0.091 12.3 0.9 0.19 11.3 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) APG6 PF04111.7 ESL08967.1 - 0.53 9.2 15.1 0.38 9.7 0.3 2.9 1 1 2 3 3 3 0 Autophagy protein Apg6 CALCOCO1 PF07888.6 ESL08967.1 - 0.55 8.4 11.3 0.74 8.0 7.8 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HALZ PF02183.13 ESL08967.1 - 1.2 8.9 18.7 7.7 6.3 0.3 5.7 6 1 0 6 6 6 0 Homeobox associated leucine zipper Xlink PF00193.12 ESL08968.1 - 0.14 12.3 0.1 0.34 11.0 0.0 1.8 1 1 1 2 2 2 0 Extracellular link domain DUF3552 PF12072.3 ESL08968.1 - 0.48 9.6 18.3 3.8 6.6 9.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3552) GLTSCR1 PF15249.1 ESL08968.1 - 1.3 9.1 8.6 0.16 12.0 1.3 2.6 3 0 0 3 3 3 0 Glioma tumor suppressor candidate region OmpH PF03938.9 ESL08968.1 - 5.3 6.9 14.3 15 5.4 0.1 2.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Phosphodiest PF01663.17 ESL08970.1 - 3.1e-10 39.9 0.1 4.5e-10 39.4 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 ESL08970.1 - 0.001 18.5 0.2 0.0016 17.8 0.2 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 ESL08970.1 - 0.0081 15.3 0.2 0.024 13.8 0.1 1.8 1 1 0 1 1 1 1 Sulfatase WD40 PF00400.27 ESL08972.1 - 1.2e-18 66.2 13.8 1.9e-06 27.4 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat Trm112p PF03966.11 ESL08972.1 - 0.13 12.6 0.0 3.6 8.0 0.0 2.5 2 0 0 2 2 2 0 Trm112p-like protein ubiquitin PF00240.18 ESL08973.1 - 1.8e-05 24.0 0.0 3.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family EPL1 PF10513.4 ESL08973.1 - 0.01 16.0 1.5 0.02 15.1 1.0 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF2407 PF10302.4 ESL08973.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.7 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain CPSF100_C PF13299.1 ESL08973.1 - 0.44 10.7 1.4 0.42 10.7 0.1 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.1 ESL08973.1 - 0.44 8.1 10.5 0.77 7.3 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) APC_CDC26 PF10471.4 ESL08973.1 - 6.4 7.5 12.7 8.7 7.1 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 PAT1 PF09770.4 ESL08973.1 - 8.5 4.4 23.6 13 3.9 16.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ACBP PF00887.14 ESL08974.1 - 9.9e-29 98.8 0.1 1.1e-28 98.7 0.1 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein TPR_MLP1_2 PF07926.7 ESL08975.1 - 2.2e-06 27.4 4.9 0.00063 19.5 0.1 3.6 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein DUF2458 PF10454.4 ESL08975.1 - 0.0081 16.0 0.4 0.0081 16.0 0.3 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2458) DUF972 PF06156.8 ESL08975.1 - 0.077 13.3 18.4 0.18 12.1 0.5 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF972) IncA PF04156.9 ESL08975.1 - 0.43 10.1 22.1 0.22 11.1 0.3 4.1 4 0 0 4 4 4 0 IncA protein CENP-F_leu_zip PF10473.4 ESL08975.1 - 0.78 9.5 27.3 0.31 10.8 1.6 3.9 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KIAA1430 PF13879.1 ESL08975.1 - 0.97 9.8 7.0 0.39 11.1 0.4 3.2 4 0 0 4 4 4 0 KIAA1430 homologue NPV_P10 PF05531.7 ESL08975.1 - 2.7 8.2 10.9 14 6.0 0.5 4.6 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.12 ESL08975.1 - 2.9 7.5 18.0 0.13 11.9 1.5 4.4 4 0 0 4 4 4 0 Prefoldin subunit THOC7 PF05615.8 ESL08975.1 - 3.8 7.7 17.8 0.04 14.1 2.2 3.2 4 0 0 4 4 4 0 Tho complex subunit 7 Kinetocho_Slk19 PF12709.2 ESL08975.1 - 5 7.2 12.0 1.6 8.8 0.2 3.7 3 0 0 3 3 3 0 Central kinetochore-associated HEAT_EZ PF13513.1 ESL08976.1 - 1.3e-09 38.1 16.8 0.00017 21.9 0.0 7.3 5 2 4 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.1 ESL08976.1 - 3.9e-09 36.6 12.1 0.0026 18.0 0.0 6.1 2 2 6 8 8 8 3 HEAT repeats HEAT PF02985.17 ESL08976.1 - 4.7e-08 32.4 15.0 0.18 11.9 0.0 7.5 8 0 0 8 8 8 3 HEAT repeat IBN_N PF03810.14 ESL08976.1 - 1.5e-06 27.9 0.6 7.4e-06 25.7 0.1 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.2 ESL08976.1 - 0.0057 17.0 0.0 0.4 11.1 0.0 3.4 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 ESL08976.1 - 0.02 14.2 0.4 8.1 5.7 0.0 3.7 3 1 0 3 3 3 0 CLASP N terminal Arm PF00514.18 ESL08976.1 - 5.6 6.9 6.9 11 6.0 0.0 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat AAA_5 PF07728.9 ESL08977.1 - 4.9e-28 97.6 0.0 2.6e-17 62.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL08977.1 - 4.1e-12 46.4 0.1 9.6e-05 22.4 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain Sigma54_activ_2 PF14532.1 ESL08977.1 - 5e-12 46.0 0.0 3.7e-05 23.7 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain Sigma54_activat PF00158.21 ESL08977.1 - 1.7e-11 43.8 0.0 9.2e-05 21.9 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 ESL08977.1 - 8.2e-09 35.6 0.0 0.0058 16.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESL08977.1 - 9.1e-09 35.6 0.0 0.00045 20.4 0.0 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESL08977.1 - 1.6e-08 34.4 0.0 0.00068 19.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.22 ESL08977.1 - 5.8e-08 33.1 0.0 0.0016 18.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_3 PF07726.6 ESL08977.1 - 8.6e-08 31.8 0.0 0.00012 21.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 ESL08977.1 - 9.6e-08 31.6 0.3 0.0055 16.3 0.1 2.4 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 ESL08977.1 - 2.5e-07 31.5 0.0 0.037 14.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 ESL08977.1 - 3e-07 30.0 0.0 0.0015 18.0 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein DUF258 PF03193.11 ESL08977.1 - 5.9e-07 28.8 0.1 0.028 13.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 ESL08977.1 - 1.5e-06 27.3 0.0 0.0014 17.5 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein RNA_helicase PF00910.17 ESL08977.1 - 3.1e-06 27.2 0.0 0.036 14.2 0.0 2.4 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.7 ESL08977.1 - 4.1e-06 26.5 0.0 0.08 12.6 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.1 ESL08977.1 - 1.5e-05 25.2 0.0 0.022 15.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ESL08977.1 - 2.2e-05 23.6 0.0 0.055 12.5 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin DUF815 PF05673.8 ESL08977.1 - 5.4e-05 22.2 0.1 0.15 10.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_2 PF07724.9 ESL08977.1 - 0.00013 21.9 0.0 0.57 10.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_29 PF13555.1 ESL08977.1 - 0.00016 21.0 0.0 0.73 9.4 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain Mg_chelatase PF01078.16 ESL08977.1 - 0.00028 20.1 0.0 0.68 9.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESL08977.1 - 0.00031 20.4 0.0 0.4 10.4 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain PhoH PF02562.11 ESL08977.1 - 0.00037 19.7 0.1 0.83 8.8 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein DUF2791 PF10923.3 ESL08977.1 - 0.00053 18.6 0.0 0.22 10.0 0.0 2.2 2 0 0 2 2 2 1 P-loop Domain of unknown function (DUF2791) AAA_10 PF12846.2 ESL08977.1 - 0.00062 19.3 0.0 0.43 9.9 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain KaiC PF06745.8 ESL08977.1 - 0.00066 18.8 0.0 0.57 9.2 0.0 2.3 2 0 0 2 2 2 2 KaiC AAA_25 PF13481.1 ESL08977.1 - 0.00073 18.9 0.0 0.16 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 ESL08977.1 - 0.0033 17.2 0.1 0.073 12.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.13 ESL08977.1 - 0.0034 16.8 0.0 0.37 10.2 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family ATP-synt_ab PF00006.20 ESL08977.1 - 0.0061 16.0 0.0 1.7 8.0 0.0 2.2 1 1 1 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DEAD PF00270.24 ESL08977.1 - 0.0067 15.9 0.0 0.064 12.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase TIP49 PF06068.8 ESL08977.1 - 0.007 15.1 0.1 1.2 7.7 0.0 2.1 2 0 0 2 2 2 1 TIP49 C-terminus MMR_HSR1 PF01926.18 ESL08977.1 - 0.0093 15.9 0.0 4.4 7.2 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase KAP_NTPase PF07693.9 ESL08977.1 - 0.0094 14.9 0.0 1.1 8.1 0.0 2.3 2 1 0 2 2 2 1 KAP family P-loop domain RuvB_N PF05496.7 ESL08977.1 - 0.011 14.7 0.0 0.66 8.9 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus NTPase_1 PF03266.10 ESL08977.1 - 0.012 15.3 0.2 2.6 7.7 0.0 3.0 3 0 0 3 3 3 0 NTPase PduV-EutP PF10662.4 ESL08977.1 - 0.026 14.0 0.2 3.2 7.2 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 ESL08977.1 - 0.027 14.0 0.0 5.2 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 ESL08977.1 - 0.028 14.2 0.0 0.67 9.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 Bac_DnaA PF00308.13 ESL08977.1 - 0.031 13.9 0.1 0.83 9.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein DUF2075 PF09848.4 ESL08977.1 - 0.04 12.8 0.1 2.9 6.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DNA_pol3_delta2 PF13177.1 ESL08977.1 - 0.044 13.4 0.1 11 5.6 0.0 2.6 3 0 0 3 3 2 0 DNA polymerase III, delta subunit Miro PF08477.8 ESL08977.1 - 0.064 13.7 0.1 2.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein Rad17 PF03215.10 ESL08977.1 - 0.075 11.7 0.0 4.6 5.7 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein CoaE PF01121.15 ESL08977.1 - 0.11 11.8 0.2 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_28 PF13521.1 ESL08977.1 - 0.12 12.3 0.0 18 5.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain HEAT_2 PF13646.1 ESL08979.1 - 0.025 14.8 0.3 0.062 13.5 0.2 1.6 1 1 0 1 1 1 0 HEAT repeats Pkinase PF00069.20 ESL08980.1 - 9.8e-26 90.4 0.0 1.1e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08980.1 - 1e-08 34.5 0.0 1.1e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL08980.1 - 8.3e-05 22.4 0.0 0.00044 20.0 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL08980.1 - 0.0095 15.0 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESL08980.1 - 0.043 13.1 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESL08980.1 - 0.11 11.4 0.0 0.14 11.0 0.0 1.3 1 1 0 1 1 1 0 Kinase-like Pkinase PF00069.20 ESL08981.1 - 8.3e-54 182.4 0.0 1e-53 182.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL08981.1 - 1.4e-39 135.7 0.0 1.9e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL08981.1 - 1.6e-07 30.5 0.0 2.5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL08981.1 - 0.011 15.5 0.1 2.7 7.6 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Taxilin PF09728.4 ESL08982.1 - 2e-05 23.8 44.9 2.5e-05 23.5 31.1 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein IncA PF04156.9 ESL08982.1 - 0.67 9.5 52.9 2.4 7.7 10.7 2.2 1 1 1 2 2 2 0 IncA protein NPV_P10 PF05531.7 ESL08982.1 - 0.91 9.8 6.9 3.4 7.9 0.2 3.4 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Allexi_40kDa PF05549.6 ESL08982.1 - 7.5 5.7 14.2 9.3 5.4 4.4 2.2 1 1 0 2 2 2 0 Allexivirus 40kDa protein Glyco_hydro_47 PF01532.15 ESL08983.1 - 2.4e-115 385.7 0.0 3e-115 385.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 adh_short PF00106.20 ESL08984.1 - 8.8e-36 123.3 0.3 1.3e-35 122.7 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESL08984.1 - 1.5e-21 77.2 0.0 1.9e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESL08984.1 - 5.2e-14 52.2 0.1 8.3e-14 51.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESL08984.1 - 0.0017 17.8 0.1 0.0045 16.4 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DnaJ PF00226.26 ESL08985.1 - 1.2e-16 60.1 1.8 7.3e-16 57.6 0.2 2.3 2 1 0 2 2 2 1 DnaJ domain CBP4 PF07960.6 ESL08985.1 - 0.27 10.8 6.1 0.5 9.9 4.2 1.4 1 0 0 1 1 1 0 CBP4 DUF1690 PF07956.6 ESL08985.1 - 0.53 10.2 4.8 0.87 9.5 3.3 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Tom37_C PF11801.3 ESL08985.1 - 0.67 9.7 3.7 0.94 9.3 2.6 1.3 1 0 0 1 1 1 0 Tom37 C-terminal domain V_ATPase_I PF01496.14 ESL08985.1 - 3.8 5.2 5.1 4.6 4.9 3.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Frigida PF07899.6 ESL08986.1 - 0.085 11.6 0.1 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Frigida-like protein Erythrovirus_X PF06795.6 ESL08986.1 - 0.27 11.2 0.0 1.3 9.0 0.0 2.0 2 0 0 2 2 2 0 Erythrovirus X protein Synaptobrevin PF00957.16 ESL08988.1 - 2.1e-27 94.5 0.3 4.1e-27 93.6 0.1 1.5 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.1 ESL08988.1 - 8.8e-16 57.2 0.1 1.3e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain RPW8 PF05659.6 ESL08988.1 - 0.063 12.8 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 LRR_4 PF12799.2 ESL08989.1 - 0.0058 16.2 0.0 0.085 12.5 0.0 2.4 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) Macoilin PF09726.4 ESL08990.1 - 1.5 6.9 10.1 0.71 8.0 3.8 2.1 2 0 0 2 2 2 0 Transmembrane protein FtsJ PF01728.14 ESL08991.1 - 3.5e-40 137.9 0.0 4.1e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Peptidase_M17 PF00883.16 ESL08994.1 - 1.1e-86 290.5 0.0 1.5e-86 290.1 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain LRR_9 PF14580.1 ESL08995.1 - 1.3e-15 57.3 0.8 2.1e-15 56.6 0.6 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 ESL08995.1 - 6.5e-13 47.9 0.1 1.1e-07 31.2 0.2 3.6 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL08995.1 - 1.3e-07 31.2 3.0 1.2e-06 28.1 1.3 2.7 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 ESL08995.1 - 0.075 13.1 7.6 11 6.5 0.2 4.4 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 ESL08995.1 - 2.4 8.4 7.8 4.6 7.6 0.1 3.6 3 1 2 5 5 5 0 Leucine Rich repeat 2Fe-2S_thioredx PF01257.14 ESL08996.1 - 3.9e-49 165.9 0.0 4.8e-49 165.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin UDPGT PF00201.13 ESL08997.1 - 5.4e-27 94.5 0.0 2e-26 92.6 0.0 1.8 2 1 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESL08997.1 - 9.8e-05 22.0 0.0 0.00016 21.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.1 ESL08997.1 - 0.0047 17.0 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_3 PF13528.1 ESL08997.1 - 0.028 13.6 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 1 Flg_new PF09479.5 ESL08997.1 - 0.061 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) MtrF PF09472.5 ESL08997.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Tubulin_C PF03953.12 ESL08998.1 - 8.2e-43 145.4 0.1 1.1e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Carn_acyltransf PF00755.15 ESL08999.1 - 6.8e-84 282.0 0.0 8.3e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase TMEM192 PF14802.1 ESL09000.1 - 0.096 11.5 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 TMEM192 family ABC_tran PF00005.22 ESL09001.1 - 1.2e-31 109.7 0.1 3.3e-16 59.8 0.0 3.4 3 0 0 3 3 3 3 ABC transporter AAA_21 PF13304.1 ESL09001.1 - 6.9e-11 42.6 1.7 0.002 18.1 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_29 PF13555.1 ESL09001.1 - 3.5e-10 39.2 0.2 0.00048 19.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 ESL09001.1 - 5.5e-07 29.0 2.2 0.37 9.9 0.2 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 ESL09001.1 - 1.7e-06 27.2 0.1 0.016 14.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_33 PF13671.1 ESL09001.1 - 2.2e-06 27.5 0.4 0.024 14.5 0.1 2.5 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 ESL09001.1 - 4.4e-06 27.1 0.1 0.031 14.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ESL09001.1 - 1.1e-05 26.2 1.5 0.074 13.8 0.0 3.2 3 2 0 3 3 3 2 AAA domain AAA_10 PF12846.2 ESL09001.1 - 1.3e-05 24.7 0.8 0.069 12.5 0.0 2.5 3 0 0 3 3 2 2 AAA-like domain Miro PF08477.8 ESL09001.1 - 2.9e-05 24.5 0.1 0.039 14.4 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein AAA_22 PF13401.1 ESL09001.1 - 4.6e-05 23.5 0.5 0.35 11.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 ESL09001.1 - 7.6e-05 22.4 0.0 0.078 12.6 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESL09001.1 - 0.00011 22.1 0.1 0.24 11.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL09001.1 - 0.00017 21.4 0.8 0.17 11.6 0.2 2.3 2 0 0 2 2 2 2 Dynamin family AAA_15 PF13175.1 ESL09001.1 - 0.00021 20.5 0.0 0.23 10.4 0.0 3.4 4 0 0 4 4 4 1 AAA ATPase domain FtsK_SpoIIIE PF01580.13 ESL09001.1 - 0.00025 20.5 0.1 0.2 11.0 0.1 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Zeta_toxin PF06414.7 ESL09001.1 - 0.00028 20.0 0.1 0.7 8.9 0.0 2.2 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 ESL09001.1 - 0.00045 19.6 0.0 0.49 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 ESL09001.1 - 0.00061 19.4 0.6 0.15 11.6 0.0 2.8 2 0 0 2 2 2 1 NACHT domain SRP54 PF00448.17 ESL09001.1 - 0.0012 18.2 0.2 0.3 10.4 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.1 ESL09001.1 - 0.0019 18.2 4.8 0.0064 16.4 0.0 2.9 3 1 0 3 3 2 1 AAA ATPase domain AIG1 PF04548.11 ESL09001.1 - 0.0022 17.1 0.2 0.48 9.4 0.0 2.4 2 0 0 2 2 2 1 AIG1 family DUF3584 PF12128.3 ESL09001.1 - 0.0024 15.3 3.1 0.24 8.7 0.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) cobW PF02492.14 ESL09001.1 - 0.0032 16.9 0.4 0.64 9.4 0.1 2.6 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 ESL09001.1 - 0.0036 17.2 0.2 2.8 7.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.9 ESL09001.1 - 0.004 16.8 0.1 0.76 9.4 0.0 3.0 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) Arf PF00025.16 ESL09001.1 - 0.0043 16.3 0.1 0.68 9.1 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_30 PF13604.1 ESL09001.1 - 0.0049 16.4 0.5 0.76 9.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.1 ESL09001.1 - 0.0049 16.7 0.3 4.5 7.1 0.0 3.3 4 0 0 4 4 4 0 AAA domain AAA PF00004.24 ESL09001.1 - 0.0077 16.4 0.1 8 6.6 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.20 ESL09001.1 - 0.01 15.3 0.1 1 8.8 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.4 ESL09001.1 - 0.012 15.0 0.2 5.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.15 ESL09001.1 - 0.013 14.1 0.1 2.2 6.8 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Septin PF00735.13 ESL09001.1 - 0.018 14.0 0.1 2.9 6.8 0.0 2.2 2 0 0 2 2 2 0 Septin RNA_helicase PF00910.17 ESL09001.1 - 0.02 15.0 0.1 7.9 6.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase ArgK PF03308.11 ESL09001.1 - 0.021 13.5 0.1 4.8 5.8 0.0 2.3 2 0 0 2 2 2 0 ArgK protein AAA_19 PF13245.1 ESL09001.1 - 0.024 14.3 0.3 0.85 9.4 0.1 2.6 2 0 0 2 2 2 0 Part of AAA domain MutS_V PF00488.16 ESL09001.1 - 0.028 13.8 0.0 2.3 7.5 0.0 2.5 2 0 0 2 2 2 0 MutS domain V VirE PF05272.6 ESL09001.1 - 0.057 12.8 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E DUF815 PF05673.8 ESL09001.1 - 0.066 12.1 1.4 3.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SE PF00437.15 ESL09001.1 - 0.076 11.9 0.0 2.9 6.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.21 ESL09001.1 - 0.084 12.3 0.1 13 5.1 0.0 2.7 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 ESL09001.1 - 0.11 12.7 0.6 8.9 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 ESL09001.1 - 0.12 12.0 0.2 5 6.7 0.0 2.7 2 1 0 2 2 2 0 Archaeal ATPase ATP_bind_1 PF03029.12 ESL09001.1 - 0.13 11.7 1.0 5.8 6.3 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DAP3 PF10236.4 ESL09001.1 - 0.13 11.1 0.9 6.9 5.4 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Mg_chelatase PF01078.16 ESL09001.1 - 0.16 11.1 1.8 4.8 6.2 0.0 2.6 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 ESL09001.1 - 0.16 10.9 0.0 9.8 5.1 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_13 PF13166.1 ESL09001.1 - 0.16 10.3 1.2 2.4 6.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 ESL09001.1 - 0.21 10.8 0.4 23 4.2 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Gtr1_RagA PF04670.7 ESL09001.1 - 0.33 10.0 1.1 10 5.1 0.1 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region DUF87 PF01935.12 ESL09001.1 - 0.84 9.3 2.4 1.3 8.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF87 SCO1-SenC PF02630.9 ESL09002.1 - 1.4e-45 155.0 0.0 1.8e-45 154.6 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.1 ESL09002.1 - 0.00043 20.3 0.0 0.00078 19.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 ESL09002.1 - 0.0011 18.6 0.0 0.0039 16.8 0.0 2.0 1 1 1 2 2 2 1 AhpC/TSA family DUF4591 PF15261.1 ESL09003.1 - 1.1e-12 48.3 23.5 2.6e-09 37.4 5.2 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4591) HSP70 PF00012.15 ESL09004.1 - 1.3e-112 376.7 0.0 1.6e-112 376.4 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL09004.1 - 0.027 13.0 0.0 0.069 11.7 0.0 1.7 1 1 0 1 1 1 0 MreB/Mbl protein FGGY_C PF02782.11 ESL09004.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Rep_fac-A_C PF08646.5 ESL09006.1 - 5.7e-42 142.8 1.9 1.2e-39 135.3 0.4 3.0 3 0 0 3 3 3 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 ESL09006.1 - 6e-13 48.4 0.0 1.1e-10 41.1 0.0 2.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain DZR PF12773.2 ESL09006.1 - 0.028 14.2 1.5 0.054 13.3 1.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon Sgf11 PF08209.6 ESL09006.1 - 0.086 12.1 2.3 5.6 6.3 0.3 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zinc-ribbons_6 PF07191.7 ESL09006.1 - 0.1 12.4 1.2 0.22 11.3 0.8 1.5 1 0 0 1 1 1 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.2 ESL09006.1 - 0.1 12.3 2.9 0.19 11.5 2.0 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 ESL09006.1 - 0.11 12.2 0.4 0.21 11.3 0.3 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon His_Phos_1 PF00300.17 ESL09007.1 - 2.5e-10 40.6 0.0 4.6e-10 39.8 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Endonuclease_NS PF01223.18 ESL09008.1 - 3.7e-60 203.0 0.0 5e-60 202.6 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.1 ESL09008.1 - 0.014 15.3 0.4 0.036 14.1 0.3 1.6 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease Ribosomal_S9 PF00380.14 ESL09010.1 - 8e-08 32.5 0.0 1.4e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 WD40 PF00400.27 ESL09012.1 - 1.1e-09 37.7 4.4 0.0087 15.9 0.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat GTP_EFTU PF00009.22 ESL09015.1 - 1e-42 145.7 0.0 1.9e-40 138.2 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL09015.1 - 5.4e-07 29.7 0.1 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.18 ESL09015.1 - 0.0025 17.7 0.0 0.0059 16.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL09015.1 - 0.0069 15.6 0.1 0.024 13.9 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU_D2 PF03144.20 ESL09015.1 - 0.034 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 Elongation factor Tu domain 2 G-alpha PF00503.15 ESL09015.1 - 0.26 9.9 0.3 0.58 8.7 0.1 1.5 2 0 0 2 2 2 0 G-protein alpha subunit HBS1_N PF08938.5 ESL09015.1 - 0.68 10.0 0.0 0.68 10.0 0.0 2.5 2 0 0 2 2 2 0 HBS1 N-terminus DUF4490 PF14892.1 ESL09016.1 - 0.078 12.6 0.2 0.13 11.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4490) Ribosomal_L36e PF01158.13 ESL09017.1 - 2.7e-34 117.0 5.3 3.5e-34 116.6 3.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e Ribosomal_L27e PF01777.13 ESL09018.1 - 1e-26 92.8 2.7 1.5e-26 92.3 1.8 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 ESL09018.1 - 5.6e-07 29.0 0.2 1.3e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 KOW motif Lactamase_B_2 PF12706.2 ESL09019.1 - 2.5e-14 53.2 0.1 3.1e-14 52.9 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESL09019.1 - 1.3e-08 34.7 0.2 4.3e-08 33.0 0.2 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Myosin_tail_1 PF01576.14 ESL09020.1 - 0.00092 17.0 16.0 0.00092 17.0 11.1 2.0 1 1 1 2 2 2 1 Myosin tail Birna_VP5 PF03042.9 ESL09020.1 - 0.018 14.5 2.3 0.049 13.1 1.0 2.0 2 1 0 2 2 2 0 Birnavirus VP5 protein DUF4201 PF13870.1 ESL09020.1 - 0.023 14.1 14.4 0.065 12.6 9.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF1192 PF06698.6 ESL09020.1 - 0.27 11.0 0.2 0.27 11.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF641 PF04859.7 ESL09020.1 - 0.35 10.6 8.1 2.1 8.1 2.4 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Kinetocho_Slk19 PF12709.2 ESL09020.1 - 0.55 10.3 9.3 3.8 7.6 1.1 3.4 3 0 0 3 3 3 0 Central kinetochore-associated Bap31 PF05529.7 ESL09020.1 - 2.1 7.7 5.7 13 5.1 0.3 2.3 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like Med9 PF07544.8 ESL09020.1 - 3.7 7.3 8.0 25 4.7 2.9 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4239 PF14023.1 ESL09020.1 - 5.1 6.3 5.7 2.5 7.3 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) DUF2746 PF10874.3 ESL09020.1 - 6.7 6.9 10.3 4.7 7.4 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2746) PET122 PF05476.6 ESL09022.1 - 0.084 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 PET122 Sel1 PF08238.7 ESL09023.1 - 0.015 15.9 0.2 0.025 15.2 0.1 1.4 1 0 0 1 1 1 0 Sel1 repeat SPX PF03105.14 ESL09024.1 - 0.00052 19.8 3.8 0.00052 19.8 2.6 5.1 3 1 1 5 5 5 1 SPX domain 3HCDH PF00725.17 ESL09025.1 - 7.5e-07 29.4 0.5 0.0051 17.1 0.0 3.0 3 1 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Ribosomal_L29 PF00831.18 ESL09025.1 - 0.13 11.9 0.1 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal L29 protein EF-hand_7 PF13499.1 ESL09026.1 - 2.4e-07 30.7 0.5 1e-05 25.5 0.1 3.5 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL09026.1 - 6e-06 25.1 0.3 0.00062 18.8 0.0 3.8 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.1 ESL09026.1 - 2.8e-05 23.6 1.1 0.0071 16.1 0.0 4.1 4 0 0 4 4 4 1 EF-hand domain Ax_dynein_light PF10211.4 ESL09026.1 - 0.00047 20.0 2.3 0.4 10.5 0.3 2.8 1 1 1 2 2 2 2 Axonemal dynein light chain EF-hand_8 PF13833.1 ESL09026.1 - 0.0016 17.9 0.3 0.45 10.1 0.0 4.0 3 1 1 4 4 4 1 EF-hand domain pair Cep57_CLD_2 PF14197.1 ESL09026.1 - 0.02 14.8 3.0 0.09 12.7 1.1 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF972 PF06156.8 ESL09026.1 - 0.3 11.4 2.9 0.42 10.9 0.1 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF972) Smg4_UPF3 PF03467.10 ESL09027.1 - 0.014 15.3 0.0 0.92 9.4 0.0 2.6 2 0 0 2 2 2 0 Smg-4/UPF3 family RRM_1 PF00076.17 ESL09029.1 - 1.6e-10 40.4 0.0 4e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL09029.1 - 7.1e-07 28.9 0.0 0.00082 19.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL09029.1 - 8e-07 28.9 0.0 0.0049 16.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) THRAP3_BCLAF1 PF15440.1 ESL09030.1 - 0.0013 17.4 4.9 0.0023 16.6 3.4 1.4 1 0 0 1 1 1 1 THRAP3/BCLAF1 family ATP-synt_F6 PF05511.6 ESL09030.1 - 0.33 10.8 3.2 1.1 9.1 0.0 2.8 2 1 1 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 UPF0231 PF06062.6 ESL09030.1 - 1.1 9.1 4.1 1.8 8.5 0.7 2.4 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0231) DUF641 PF04859.7 ESL09030.1 - 8.2 6.1 15.0 0.62 9.8 5.3 2.2 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Fez1 PF06818.10 ESL09030.1 - 8.5 6.3 23.5 1 9.3 5.1 2.2 1 1 1 2 2 2 0 Fez1 PNP_UDP_1 PF01048.15 ESL09031.1 - 5.5e-40 136.8 0.4 7e-40 136.4 0.3 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily ApoLp-III PF07464.6 ESL09032.1 - 0.0032 17.5 5.4 0.0084 16.1 3.8 1.7 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) DUF2334 PF10096.4 ESL09032.1 - 0.09 12.1 0.2 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Imm42 PF15601.1 ESL09032.1 - 0.28 10.6 2.3 5.2 6.4 0.0 2.9 2 0 0 2 2 2 0 Immunity protein 42 Tctex-1 PF03645.8 ESL09032.1 - 2.4 8.0 4.1 8.3 6.3 0.3 3.2 3 0 0 3 3 3 0 Tctex-1 family Kelch_5 PF13854.1 ESL09033.1 - 1e-13 50.8 3.2 1.3e-05 25.0 0.0 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 ESL09033.1 - 3.6e-13 49.2 0.8 1.8e-06 27.9 0.0 5.2 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESL09033.1 - 4e-13 48.9 3.9 1.4e-07 31.1 0.0 5.9 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESL09033.1 - 2.5e-12 46.0 0.4 4.9e-07 29.2 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 ESL09033.1 - 7.8e-10 38.1 1.4 9e-06 25.1 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESL09033.1 - 1.9e-09 37.3 0.2 0.00051 20.1 0.0 4.7 5 0 0 5 5 5 2 Kelch motif Lactamase_B PF00753.22 ESL09035.1 - 4.9e-09 36.1 3.1 2.3e-08 33.9 2.2 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily IMS PF00817.15 ESL09036.1 - 1.7e-35 122.0 0.0 4.3e-35 120.7 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 ESL09036.1 - 4.9e-10 39.4 0.2 1.2e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 ESL09036.1 - 1.5e-05 24.7 0.0 5.8e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 IMS family HHH motif RESP18 PF14948.1 ESL09036.1 - 0.047 13.7 0.2 0.31 11.0 0.1 2.2 2 0 0 2 2 2 0 RESP18 domain Acyltransferase PF01553.16 ESL09038.1 - 2.5e-17 62.5 0.0 7.6e-17 60.9 0.0 1.8 3 0 0 3 3 3 1 Acyltransferase EcsB PF05975.7 ESL09038.1 - 0.096 11.1 5.1 0.12 10.8 3.5 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB DNAPolymera_Pol PF11590.3 ESL09038.1 - 0.22 11.2 1.0 1.2 8.8 0.2 2.2 2 0 0 2 2 2 0 DNA polymerase catalytic subunit Pol SET PF00856.23 ESL09039.1 - 4.9e-11 43.2 0.0 2.3e-08 34.4 0.0 2.1 2 0 0 2 2 2 2 SET domain Delta_lysin PF05372.6 ESL09039.1 - 0.15 11.4 0.2 0.66 9.3 0.0 1.9 2 0 0 2 2 2 0 Delta lysin family Pkinase PF00069.20 ESL09040.1 - 2.4e-28 98.9 0.0 1.9e-27 96.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09040.1 - 5.6e-09 35.4 0.0 9.2e-07 28.1 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Metallophos PF00149.23 ESL09041.1 - 7.6e-10 38.5 0.6 1.8e-09 37.2 0.4 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL09041.1 - 3.3e-08 33.5 0.0 6.2e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF1242 PF06842.7 ESL09042.1 - 5.7e-14 51.3 0.4 8.7e-14 50.7 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) IQ PF00612.22 ESL09045.1 - 2.5e-20 70.1 37.0 0.00012 21.3 0.9 7.4 6 0 0 6 6 6 6 IQ calmodulin-binding motif TPR_12 PF13424.1 ESL09045.1 - 1.2 9.1 13.7 2.2 8.2 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat XRN_N PF03159.13 ESL09046.1 - 2.4e-45 154.7 0.0 5e-23 81.7 0.0 2.1 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus PPR_2 PF13041.1 ESL09047.1 - 0.00074 19.4 0.0 0.026 14.4 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.1 ESL09047.1 - 0.0043 17.2 0.2 6.6 7.2 0.0 4.0 3 0 0 3 3 3 2 Pentatricopeptide repeat domain Kinesin PF00225.18 ESL09048.1 - 1.5e-81 273.6 4.4 5.8e-48 163.3 0.0 3.0 2 1 0 3 3 3 2 Kinesin motor domain DUF3138 PF11336.3 ESL09048.1 - 5.1 5.1 6.9 1.6 6.7 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Complex1_LYR PF05347.10 ESL09050.1 - 3.6e-07 29.8 0.1 2.6e-06 27.1 0.0 2.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESL09050.1 - 0.00019 21.5 0.1 0.00019 21.5 0.0 3.0 3 1 0 3 3 3 1 Complex1_LYR-like CoaE PF01121.15 ESL09051.1 - 4.9e-22 78.1 7.2 2.7e-20 72.5 5.0 2.6 1 1 0 1 1 1 1 Dephospho-CoA kinase Macoilin PF09726.4 ESL09052.1 - 0.0023 16.3 17.4 0.14 10.3 5.2 3.0 2 1 0 3 3 3 2 Transmembrane protein EIAV_Rev PF11129.3 ESL09052.1 - 0.024 14.6 2.4 0.11 12.4 0.6 2.2 2 0 0 2 2 2 0 Rev protein of equine infectious anaemia virus bZIP_1 PF00170.16 ESL09052.1 - 0.043 13.7 0.1 0.043 13.7 0.1 4.2 4 1 1 5 5 5 0 bZIP transcription factor FhuF PF06276.7 ESL09052.1 - 0.082 12.8 1.6 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 Ferric iron reductase FhuF-like transporter Occludin_ELL PF07303.8 ESL09052.1 - 1.6 9.5 10.3 5.5 7.7 0.7 3.3 3 1 1 4 4 4 0 Occludin homology domain Nnf1 PF03980.9 ESL09052.1 - 1.9 8.4 12.0 0.35 10.8 0.3 3.4 2 1 1 3 3 3 0 Nnf1 DivIC PF04977.10 ESL09052.1 - 4 7.0 19.8 11 5.6 0.6 4.6 3 1 1 4 4 4 0 Septum formation initiator HALZ PF02183.13 ESL09052.1 - 4.3 7.1 16.9 1.4 8.6 0.1 4.3 3 1 1 4 4 4 0 Homeobox associated leucine zipper FlaC_arch PF05377.6 ESL09052.1 - 4.3 7.2 12.5 1.1 9.1 0.7 4.1 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Cortex-I_coil PF09304.5 ESL09052.1 - 4.5 7.3 23.5 3.1 7.8 4.3 3.7 1 1 1 3 3 3 0 Cortexillin I, coiled coil DUF641 PF04859.7 ESL09052.1 - 4.5 7.0 21.8 2 8.2 3.3 3.9 1 1 2 4 4 4 0 Plant protein of unknown function (DUF641) USP8_interact PF08941.5 ESL09052.1 - 6.1 6.1 9.3 1.2 8.3 1.3 2.8 2 1 1 3 3 3 0 USP8 interacting GrpE PF01025.14 ESL09052.1 - 9.4 5.7 17.3 2.5 7.6 3.2 3.0 3 0 0 3 3 3 0 GrpE FliD_N PF02465.13 ESL09052.1 - 9.6 6.6 8.8 1.3 9.4 0.1 2.9 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Voltage_CLC PF00654.15 ESL09053.1 - 1.6e-87 293.8 30.3 6.3e-87 291.8 18.6 2.2 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.23 ESL09053.1 - 4e-10 39.3 0.8 4.7e-05 23.0 0.0 2.7 2 0 0 2 2 2 2 CBS domain SecY PF00344.15 ESL09054.1 - 5.9e-84 281.9 9.8 7.2e-84 281.6 6.8 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 ESL09054.1 - 4.1e-17 61.3 0.1 8.6e-17 60.3 0.0 1.6 1 0 0 1 1 1 1 Plug domain of Sec61p DUF4233 PF14017.1 ESL09054.1 - 2.6 7.9 12.9 1.1 9.2 1.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF4233) Dpy-30 PF05186.8 ESL09055.1 - 3e-08 32.9 0.1 5.5e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Dpy-30 motif DUF342 PF03961.8 ESL09056.1 - 0.00044 18.7 5.1 0.00051 18.5 3.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) CALCOCO1 PF07888.6 ESL09056.1 - 0.0084 14.4 14.6 0.011 14.0 10.1 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like V_ATPase_I PF01496.14 ESL09056.1 - 0.05 11.4 6.0 0.057 11.2 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RdRP_4 PF02123.11 ESL09056.1 - 0.097 11.3 2.0 0.1 11.3 1.4 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase PEP-utilisers_N PF05524.8 ESL09056.1 - 1.5 8.6 11.8 0.1 12.3 1.8 2.3 1 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal Syntaxin-6_N PF09177.6 ESL09056.1 - 1.6 9.2 9.7 1.1 9.6 3.6 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal APG6 PF04111.7 ESL09056.1 - 2.3 7.1 17.2 3.5 6.5 12.0 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.7 ESL09056.1 - 2.4 7.9 5.6 3.4 7.4 1.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 ESL09056.1 - 3.5 6.4 16.0 4.7 6.0 11.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ADIP PF11559.3 ESL09056.1 - 4.8 7.0 18.8 19 5.1 13.0 1.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF2968 PF11180.3 ESL09056.1 - 8.2 5.7 15.8 3.3 7.0 8.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) CENP-H PF05837.7 ESL09056.1 - 9.8 6.4 13.7 1.7 8.8 5.7 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Transket_pyr PF02779.19 ESL09058.1 - 1.4e-55 187.5 0.0 2.1e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESL09058.1 - 3.1e-49 167.3 0.0 4.7e-49 166.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component CCDC92 PF14916.1 ESL09059.1 - 0.074 12.6 0.3 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain of unknown function Leu_zip PF15294.1 ESL09060.1 - 0.0013 17.9 12.5 0.0032 16.6 8.7 1.7 1 0 0 1 1 1 1 Leucine zipper GAS PF13851.1 ESL09060.1 - 0.013 14.6 19.8 1.3 8.2 6.7 3.5 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1843 PF08898.5 ESL09060.1 - 0.079 13.0 0.7 0.079 13.0 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) DivIC PF04977.10 ESL09060.1 - 0.11 12.0 10.9 2.5 7.6 2.1 3.8 3 1 1 4 4 4 0 Septum formation initiator MSV199 PF10553.4 ESL09060.1 - 0.11 12.3 0.6 0.34 10.7 0.1 2.0 2 1 0 2 2 2 0 MSV199 domain Spc7 PF08317.6 ESL09060.1 - 1.2 7.6 16.9 0.05 12.2 6.9 2.1 2 1 0 2 2 2 0 Spc7 kinetochore protein APG6 PF04111.7 ESL09060.1 - 4.3 6.3 20.3 0.14 11.2 9.4 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 Atg14 PF10186.4 ESL09060.1 - 5.7 5.7 16.2 1.8 7.4 0.9 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TMF_TATA_bd PF12325.3 ESL09060.1 - 9.1 6.0 32.6 5.2 6.8 0.6 5.1 2 1 2 5 5 5 0 TATA element modulatory factor 1 TATA binding His_Phos_1 PF00300.17 ESL09061.1 - 4.1e-31 108.2 0.0 4.7e-31 108.0 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Clathrin PF00637.15 ESL09062.1 - 6e-16 58.3 2.1 2e-13 50.1 0.4 2.8 2 1 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.3 ESL09062.1 - 1.4e-08 34.4 0.6 2.7e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal Vps8 PF12816.2 ESL09062.1 - 0.057 12.6 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 PQQ_3 PF13570.1 ESL09062.1 - 0.058 13.6 0.2 0.87 9.9 0.0 2.8 2 0 0 2 2 2 0 PQQ-like domain zf-RING_6 PF14835.1 ESL09062.1 - 0.74 9.6 4.3 0.99 9.2 1.5 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Prok-RING_1 PF14446.1 ESL09062.1 - 0.75 9.5 8.0 2.3 8.0 5.6 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C3HC4_2 PF13923.1 ESL09062.1 - 0.89 9.6 10.6 2.7 8.0 7.3 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL09062.1 - 1.1 9.0 12.3 2.8 7.7 8.6 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 ESL09062.1 - 1.9 8.4 11.2 6.2 6.7 7.8 1.9 1 0 0 1 1 1 0 Ring finger domain Peptidase_C2 PF00648.16 ESL09063.1 - 1.5e-35 122.6 0.7 5e-18 65.1 0.0 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.17 ESL09063.1 - 1.9e-12 47.0 0.0 1.2e-10 41.2 0.0 2.7 3 0 0 3 3 3 1 Calpain large subunit, domain III LRR_6 PF13516.1 ESL09063.1 - 0.093 12.8 0.7 81 3.7 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich repeat DUF2999 PF11212.3 ESL09063.1 - 0.14 12.2 0.3 0.3 11.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) AAA PF00004.24 ESL09064.1 - 7.3e-41 139.4 0.0 2.1e-40 137.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESL09064.1 - 1.1e-06 28.3 0.3 3.5e-06 26.8 0.1 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 ESL09064.1 - 3.6e-06 27.1 0.2 5e-05 23.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL09064.1 - 4e-06 26.0 0.0 1.4e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESL09064.1 - 2.3e-05 24.1 0.1 0.00033 20.4 0.0 2.7 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 ESL09064.1 - 5.2e-05 22.7 0.8 0.0082 15.5 0.1 2.8 2 1 1 3 3 3 1 AAA domain Arch_ATPase PF01637.13 ESL09064.1 - 0.00013 21.8 0.1 0.023 14.4 0.1 2.6 1 1 0 1 1 1 1 Archaeal ATPase KaiC PF06745.8 ESL09064.1 - 0.00019 20.6 0.1 0.42 9.6 0.0 2.7 2 1 1 3 3 3 2 KaiC AAA_11 PF13086.1 ESL09064.1 - 0.00028 20.5 0.0 0.00038 20.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL09064.1 - 0.00029 20.5 0.0 0.00069 19.3 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 ESL09064.1 - 0.00036 20.5 0.0 0.00075 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 ESL09064.1 - 0.00038 20.3 0.0 0.00079 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESL09064.1 - 0.00064 19.6 0.0 0.0022 17.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESL09064.1 - 0.00078 18.9 0.3 0.0021 17.5 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESL09064.1 - 0.00094 18.3 0.0 0.0019 17.3 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.7 ESL09064.1 - 0.0012 18.5 0.1 0.029 14.0 0.0 2.5 2 1 0 3 3 3 1 NACHT domain AAA_2 PF07724.9 ESL09064.1 - 0.0013 18.7 0.0 0.0097 15.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 ESL09064.1 - 0.0013 19.5 0.2 0.0032 18.2 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESL09064.1 - 0.003 17.1 0.5 0.0058 16.2 0.3 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL09064.1 - 0.0039 17.5 0.4 0.027 14.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESL09064.1 - 0.0041 15.8 0.0 0.0075 15.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus RNA_helicase PF00910.17 ESL09064.1 - 0.0043 17.1 0.0 0.013 15.7 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_28 PF13521.1 ESL09064.1 - 0.006 16.5 0.0 0.019 14.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.7 ESL09064.1 - 0.0093 15.0 0.0 0.02 13.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Parvo_NS1 PF01057.12 ESL09064.1 - 0.02 13.8 0.0 0.032 13.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.1 ESL09064.1 - 0.027 14.5 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.8 ESL09064.1 - 0.03 13.2 0.0 0.05 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.11 ESL09064.1 - 0.034 13.3 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.22 ESL09064.1 - 0.037 14.3 0.0 0.068 13.4 0.0 1.5 2 0 0 2 2 1 0 ABC transporter Guanylate_kin PF00625.16 ESL09064.1 - 0.042 13.3 0.0 0.31 10.4 0.0 2.2 3 0 0 3 3 3 0 Guanylate kinase Sigma54_activat PF00158.21 ESL09064.1 - 0.044 13.2 0.0 0.28 10.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.6 ESL09064.1 - 0.081 12.5 0.2 0.18 11.3 0.0 1.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 ESL09064.1 - 0.088 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 ESL09064.1 - 0.089 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase tRNA_NucTransf2 PF09249.6 ESL09064.1 - 0.11 12.3 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain UPF0079 PF02367.12 ESL09064.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 BCAS2 PF05700.6 ESL09065.1 - 0.011 15.1 6.6 0.74 9.2 4.6 2.2 1 1 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) TPR_9 PF13371.1 ESL09065.1 - 0.088 12.6 0.6 0.088 12.6 0.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Xpo1 PF08389.7 ESL09067.1 - 3.5e-19 69.1 1.3 8.1e-18 64.7 0.0 3.4 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.17 ESL09067.1 - 0.00033 20.4 2.4 2.4 8.4 0.2 5.0 4 0 0 4 4 4 2 HEAT repeat zf-CCCH PF00642.19 ESL09068.1 - 1.3e-06 27.9 1.5 2.4e-06 27.1 1.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESL09068.1 - 0.00016 21.5 0.5 0.00037 20.3 0.4 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type MCM PF00493.18 ESL09070.1 - 1.2e-97 326.6 0.0 1.6e-97 326.3 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family AAA_5 PF07728.9 ESL09070.1 - 1.9e-09 37.3 0.0 3.2e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESL09070.1 - 1e-05 24.8 0.9 0.028 13.5 0.0 2.6 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESL09070.1 - 0.00054 19.5 0.0 0.0012 18.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESL09070.1 - 0.0029 16.6 0.0 0.0054 15.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Sigma54_activat PF00158.21 ESL09070.1 - 0.0064 15.9 0.1 0.031 13.7 0.1 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.24 ESL09070.1 - 0.025 14.7 0.0 0.1 12.7 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESL09070.1 - 0.037 13.9 0.0 0.086 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESL09070.1 - 0.04 13.9 0.7 0.086 12.8 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain Vps39_2 PF10367.4 ESL09071.1 - 0.00024 21.2 3.5 0.05 13.7 0.2 2.4 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 2 RRM_1 PF00076.17 ESL09071.1 - 0.17 11.5 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) E1-E2_ATPase PF00122.15 ESL09072.1 - 5.4e-50 169.5 0.3 5.4e-50 169.5 0.2 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESL09072.1 - 1.7e-23 84.1 0.0 1.2e-22 81.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 ESL09072.1 - 8.4e-18 64.5 0.2 2.3e-17 63.1 0.0 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.21 ESL09072.1 - 2.6e-16 58.8 0.0 5.3e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 ESL09072.1 - 3.3e-10 39.7 0.0 8.3e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESL09072.1 - 3.2e-09 37.2 0.0 1.1e-08 35.4 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL09072.1 - 5.5e-05 22.8 0.0 0.00086 18.9 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RNase_PH PF01138.16 ESL09074.1 - 1e-05 25.8 0.1 0.0034 17.7 0.0 2.2 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 Proteasome PF00227.21 ESL09075.1 - 2.1e-57 193.4 0.0 2.7e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESL09075.1 - 8.1e-14 50.6 0.0 2.2e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Glyco_hydro_67C PF07477.7 ESL09075.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 C-terminus Metallophos PF00149.23 ESL09076.1 - 6.5e-35 120.3 0.3 1.1e-34 119.5 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ISN1 PF06437.6 ESL09078.1 - 0.087 11.5 0.0 0.17 10.5 0.0 1.4 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase RRM_5 PF13893.1 ESL09079.1 - 1.5e-20 72.7 0.8 1.4e-10 40.8 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL09079.1 - 2.8e-14 52.8 0.2 2.8e-08 33.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL09079.1 - 1.8e-12 46.7 0.0 4e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.7 ESL09079.1 - 0.0068 16.0 1.8 0.021 14.4 0.2 2.1 2 0 0 2 2 2 1 Calcipressin DUF3588 PF12140.3 ESL09079.1 - 0.022 14.8 0.2 0.052 13.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3588) RRM_3 PF08777.6 ESL09079.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.7 2 0 0 2 2 2 0 RNA binding motif DUF1411 PF07199.6 ESL09079.1 - 0.17 11.3 2.3 1.8 7.9 0.1 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1411) CTD_bind PF04818.8 ESL09081.1 - 0.044 14.0 0.3 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 RNA polymerase II-binding domain. TPR_2 PF07719.12 ESL09082.1 - 0.011 15.6 0.8 0.04 13.8 0.5 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL09082.1 - 0.035 14.2 3.0 0.085 13.0 2.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-met PF12874.2 ESL09083.1 - 1.3e-05 25.2 1.7 2.5e-05 24.3 1.2 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type AKAP95 PF04988.7 ESL09083.1 - 0.029 14.1 0.6 0.046 13.5 0.4 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_jaz PF12171.3 ESL09083.1 - 0.041 14.0 1.2 0.08 13.1 0.8 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.7 ESL09083.1 - 0.072 12.7 0.8 0.12 12.0 0.5 1.3 1 0 0 1 1 1 0 DBF zinc finger MORN PF02493.15 ESL09084.1 - 2.2e-12 45.8 12.8 8.6e-07 28.3 0.0 6.2 6 0 0 6 6 6 3 MORN repeat IF-2B PF01008.12 ESL09085.1 - 0.0014 17.6 0.0 0.0014 17.6 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family DAO PF01266.19 ESL09086.1 - 5.4e-41 140.6 0.2 5.4e-41 140.6 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 ESL09086.1 - 0.00011 21.4 0.6 0.00019 20.6 0.4 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESL09086.1 - 0.0018 17.2 1.2 0.021 13.7 0.4 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 ESL09086.1 - 0.023 14.5 0.4 0.073 12.9 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 ESL09086.1 - 0.03 13.9 0.2 0.068 12.8 0.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.1 ESL09086.1 - 0.093 12.7 0.9 0.27 11.2 0.6 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Saccharop_dh PF03435.13 ESL09087.1 - 1.4e-24 86.8 0.1 1.9e-24 86.3 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 ESL09087.1 - 2.6e-06 27.0 0.0 9.3e-06 25.2 0.0 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESL09087.1 - 4.4e-06 26.8 0.1 1e-05 25.6 0.0 1.6 2 0 0 2 2 2 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESL09087.1 - 8e-05 21.4 0.0 0.00019 20.2 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 ESL09087.1 - 0.0015 18.4 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL09087.1 - 0.0021 17.7 0.0 0.0045 16.6 0.0 1.5 1 0 0 1 1 1 1 KR domain NmrA PF05368.8 ESL09087.1 - 0.0023 17.2 0.0 0.005 16.1 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family Shikimate_DH PF01488.15 ESL09087.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Band_7 PF01145.20 ESL09088.1 - 2.3e-22 79.7 4.3 3.2e-22 79.3 3.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF4200 PF13863.1 ESL09088.1 - 0.005 16.7 2.5 0.005 16.7 1.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) PTS_2-RNA PF01885.11 ESL09090.1 - 1.1e-51 174.7 0.0 1.7e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family RNase_T PF00929.19 ESL09090.1 - 1.4e-19 71.0 0.0 2.1e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Methyltransf_25 PF13649.1 ESL09092.1 - 2.7e-10 40.5 0.0 4e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL09092.1 - 3.1e-07 30.9 0.0 1.5e-06 28.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL09092.1 - 3.5e-05 23.5 0.0 4.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL09092.1 - 0.00095 19.6 0.0 0.016 15.7 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL09092.1 - 0.0096 15.5 0.0 0.31 10.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL09092.1 - 0.026 14.9 0.0 0.33 11.4 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain CheR PF01739.13 ESL09092.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain RINGv PF12906.2 ESL09095.1 - 1.2e-11 44.4 8.3 1.7e-11 43.9 5.7 1.2 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 ESL09095.1 - 0.00046 19.9 5.2 0.00075 19.2 3.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING-like PF08746.6 ESL09095.1 - 0.0065 16.4 2.3 0.012 15.6 1.6 1.4 1 0 0 1 1 1 1 RING-like domain COX5B PF01215.14 ESL09095.1 - 0.084 12.5 0.3 0.13 11.9 0.2 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb HypA PF01155.14 ESL09095.1 - 0.4 10.3 0.1 0.4 10.3 0.0 1.7 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-C3HC4 PF00097.20 ESL09095.1 - 0.74 9.5 4.8 1.6 8.4 3.3 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESL09095.1 - 1.4 9.0 7.9 4.1 7.5 5.5 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger Pkinase PF00069.20 ESL09097.1 - 8.1e-67 225.0 0.0 1e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09097.1 - 6.3e-25 87.7 0.0 1.3e-24 86.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09097.1 - 0.0007 18.6 0.1 0.071 12.0 0.0 2.5 3 0 0 3 3 3 2 Kinase-like zf-DHHC PF01529.15 ESL09098.1 - 2.2e-27 95.5 7.1 2.2e-27 95.5 4.9 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase TFIIS_C PF01096.13 ESL09099.1 - 3.7e-16 58.4 7.8 8.9e-16 57.2 5.4 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) PWWP PF00855.12 ESL09099.1 - 1.7e-09 37.7 0.0 4.3e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 PWWP domain Med26 PF08711.6 ESL09099.1 - 3.5e-05 23.2 0.1 8.1e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Mcm10 PF09332.6 ESL09099.1 - 0.008 15.5 10.6 0.39 10.0 0.4 3.3 2 1 1 3 3 3 3 Mcm10 replication factor Dendrin PF15498.1 ESL09099.1 - 0.036 12.5 4.2 0.046 12.2 2.9 1.1 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin SAA PF00277.13 ESL09099.1 - 0.3 11.4 3.5 0.66 10.3 2.4 1.5 1 0 0 1 1 1 0 Serum amyloid A protein TPR_12 PF13424.1 ESL09100.1 - 7.5e-21 73.8 7.6 2.1e-10 40.3 0.7 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL09100.1 - 8e-13 47.2 7.9 0.37 10.8 0.0 5.9 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.1 ESL09100.1 - 3e-10 39.5 6.4 0.00088 18.8 0.2 3.9 1 1 5 6 6 6 5 TPR repeat TPR_1 PF00515.23 ESL09100.1 - 2.9e-09 36.1 6.6 0.38 10.4 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09100.1 - 7.8e-09 34.6 1.4 0.21 11.4 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL09100.1 - 3.5e-07 29.5 6.5 3.3 7.7 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09100.1 - 0.0014 19.2 3.3 18 6.1 0.0 4.6 2 2 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09100.1 - 0.003 18.0 1.1 31 5.5 0.1 4.8 3 2 1 4 4 4 0 Tetratricopeptide repeat DUF309 PF03745.9 ESL09100.1 - 0.015 14.7 0.9 0.29 10.6 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF309) TPR_9 PF13371.1 ESL09100.1 - 0.02 14.7 4.1 0.12 12.2 0.0 3.8 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL09100.1 - 0.025 14.4 8.0 2.6 8.1 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL09100.1 - 0.4 11.2 2.9 32 5.2 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat DNA_primase_S PF01896.14 ESL09102.1 - 5e-39 133.3 0.0 8.1e-39 132.7 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Kinesin PF00225.18 ESL09104.1 - 2.3e-78 263.2 0.4 2.3e-78 263.2 0.3 2.0 2 0 0 2 2 2 1 Kinesin motor domain HAD_2 PF13419.1 ESL09104.1 - 0.4 10.8 4.6 13 5.9 0.8 2.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF342 PF03961.8 ESL09104.1 - 1.2 7.4 5.9 0.48 8.7 1.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Pkinase PF00069.20 ESL09105.1 - 4e-43 147.4 0.0 1.7e-42 145.3 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09105.1 - 1.8e-25 89.5 0.0 6.5e-24 84.3 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09105.1 - 0.0073 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESL09105.1 - 0.053 12.8 0.0 0.13 11.5 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 ESL09105.1 - 0.076 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase PX PF00787.19 ESL09105.1 - 0.12 12.1 0.2 0.33 10.7 0.1 1.7 1 0 0 1 1 1 0 PX domain Coatomer_b_Cpla PF14806.1 ESL09106.1 - 9.9e-44 148.2 1.9 4.2e-43 146.1 0.7 2.3 2 1 0 2 2 2 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 ESL09106.1 - 1.8e-37 128.1 0.0 4.7e-37 126.7 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region Adaptin_N PF01602.15 ESL09106.1 - 3.1e-29 101.6 3.7 5.2e-29 100.9 2.6 1.2 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESL09106.1 - 5.5e-05 23.3 0.7 0.0034 17.6 0.0 3.2 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.17 ESL09106.1 - 0.02 14.9 0.2 0.29 11.3 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat PaaX_C PF08223.6 ESL09106.1 - 0.023 14.3 1.1 2.9 7.5 0.0 2.4 2 0 0 2 2 2 0 PaaX-like protein C-terminal domain VMA21 PF09446.5 ESL09108.1 - 0.049 13.5 9.9 0.068 13.1 6.8 1.2 1 0 0 1 1 1 0 VMA21-like domain DUF1487 PF07368.6 ESL09108.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) DUF2244 PF10003.4 ESL09108.1 - 6.1 6.2 11.5 0.21 10.9 2.4 2.3 2 1 1 3 3 3 0 Integral membrane protein (DUF2244) Ribosomal_L5_C PF00673.16 ESL09109.1 - 1e-21 76.4 0.0 1.7e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 ESL09109.1 - 3.8e-16 58.6 0.2 2.3e-15 56.1 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L5 Glu_syn_central PF04898.9 ESL09109.1 - 0.044 13.0 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 Glutamate synthase central domain Sel1 PF08238.7 ESL09109.1 - 0.073 13.7 0.7 0.17 12.5 0.1 1.9 2 0 0 2 2 2 0 Sel1 repeat Shisa PF13908.1 ESL09110.1 - 0.014 15.5 0.2 0.017 15.2 0.2 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Rhabdo_glycop PF00974.13 ESL09110.1 - 0.07 11.3 0.2 0.093 10.9 0.2 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein DUF2306 PF10067.4 ESL09111.1 - 0.079 13.0 7.8 0.52 10.4 0.0 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2306) 2OG-FeII_Oxy_2 PF13532.1 ESL09112.1 - 0.13 12.0 0.1 0.73 9.6 0.1 2.1 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Tubulin_C PF03953.12 ESL09113.1 - 2e-34 118.3 0.0 2.5e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Inhibitor_I42 PF09394.5 ESL09114.1 - 1.8e-22 79.4 0.0 2.2e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 Myosin_TH1 PF06017.8 ESL09115.1 - 0.049 12.9 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Myosin tail Pox_A32 PF04665.7 ESL09115.1 - 0.077 12.2 0.2 2.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein S4 PF01479.20 ESL09116.1 - 3.1e-13 48.9 0.4 6.1e-13 47.9 0.3 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.14 ESL09116.1 - 0.0088 16.4 0.1 0.034 14.5 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Thioredoxin PF00085.15 ESL09117.1 - 1e-07 31.5 0.0 2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 ESL09117.1 - 7.4e-05 22.6 0.0 0.0003 20.7 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.1 ESL09117.1 - 0.00093 19.2 0.0 0.036 14.1 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESL09117.1 - 0.0018 17.8 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL09117.1 - 0.034 14.3 0.0 1.2 9.3 0.0 2.6 1 1 0 1 1 1 0 Thioredoxin-like domain DEAD PF00270.24 ESL09118.1 - 1.2e-40 138.7 0.1 9.5e-40 135.8 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL09118.1 - 5.2e-20 71.0 0.0 1.3e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESL09118.1 - 1.3e-15 56.6 0.3 2.8e-15 55.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESL09118.1 - 0.0041 16.9 0.1 0.019 14.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PUF PF00806.14 ESL09119.1 - 1e-16 59.3 0.0 0.00065 19.0 0.0 5.3 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat Vfa1 PF08432.5 ESL09119.1 - 0.003 17.5 2.3 0.0045 17.0 1.6 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.9 ESL09119.1 - 0.031 12.3 3.0 0.041 11.9 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Striatin PF08232.7 ESL09119.1 - 0.12 12.6 3.5 0.27 11.5 2.4 1.5 1 0 0 1 1 1 0 Striatin family vATP-synt_E PF01991.13 ESL09120.1 - 2.7e-40 137.7 5.5 3.1e-40 137.5 3.8 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit SPT16 PF08644.6 ESL09120.1 - 0.079 12.7 2.2 0.16 11.7 1.6 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Birna_RdRp PF04197.7 ESL09120.1 - 2.9 5.7 5.7 3.6 5.5 4.0 1.1 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) Proteasom_Rpn13 PF04683.8 ESL09121.1 - 2.6e-20 72.2 0.2 3.9e-20 71.7 0.1 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor EF-hand_1 PF00036.27 ESL09122.1 - 9.4e-29 96.5 8.3 1.5e-08 33.3 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESL09122.1 - 2.5e-25 88.3 1.2 9.4e-13 48.1 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL09122.1 - 5.1e-22 77.2 7.8 3.6e-12 45.7 0.3 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 ESL09122.1 - 4e-21 72.9 5.4 7.3e-08 31.6 0.1 4.2 3 1 1 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 ESL09122.1 - 4e-19 67.0 8.3 6e-06 25.3 0.1 3.6 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 ESL09122.1 - 5e-08 32.7 0.0 4.5e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.2 ESL09122.1 - 3.9e-07 29.7 2.5 0.02 14.6 0.6 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.5 ESL09122.1 - 0.01 15.8 0.6 4.5 7.3 0.0 2.8 2 2 0 2 2 2 0 Ca2+ insensitive EF hand DUF3911 PF13050.1 ESL09122.1 - 0.056 13.5 0.1 0.27 11.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3911) SPARC_Ca_bdg PF10591.4 ESL09122.1 - 0.15 12.1 0.0 0.4 10.7 0.0 1.7 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.20 ESL09123.1 - 4.8e-53 179.9 0.0 5.4e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09123.1 - 9e-36 123.2 0.0 1.1e-35 123.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09123.1 - 5.5e-05 22.2 0.0 0.00013 20.9 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 ESL09123.1 - 0.07 12.8 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESL09123.1 - 0.096 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 YjcZ PF13990.1 ESL09123.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 YjcZ-like protein Skp1 PF01466.14 ESL09124.1 - 4.8e-07 29.7 0.9 2.1e-06 27.6 0.6 1.9 1 1 0 1 1 1 1 Skp1 family, dimerisation domain Aa_trans PF01490.13 ESL09125.1 - 2e-05 23.2 8.0 2.3e-05 23.0 5.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1689 PF07954.6 ESL09125.1 - 0.083 12.7 0.7 0.13 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) DUF3169 PF11368.3 ESL09125.1 - 0.24 10.5 3.9 0.2 10.8 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3169) PH PF00169.24 ESL09126.1 - 5e-07 29.8 0.0 0.012 15.8 0.0 3.0 3 1 0 3 3 3 2 PH domain PH_11 PF15413.1 ESL09126.1 - 0.00046 20.4 0.5 0.087 13.0 0.0 3.3 3 1 1 4 4 4 1 Pleckstrin homology domain PH_8 PF15409.1 ESL09126.1 - 0.076 13.0 0.0 15 5.7 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain HEAT PF02985.17 ESL09127.1 - 0.072 13.2 0.1 6.4 7.1 0.0 3.5 2 0 0 2 2 2 0 HEAT repeat Beta-lactamase PF00144.19 ESL09128.1 - 2.8e-07 29.8 0.1 0.011 14.8 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase Syja_N PF02383.13 ESL09129.1 - 1.7e-21 76.3 0.0 4.7e-21 74.8 0.0 1.7 1 1 0 1 1 1 1 SacI homology domain HTH_9 PF08221.6 ESL09130.1 - 0.036 13.9 0.4 0.86 9.5 0.0 3.3 4 0 0 4 4 4 0 RNA polymerase III subunit RPC82 helix-turn-helix domain AlaDh_PNT_N PF05222.10 ESL09130.1 - 0.039 13.9 0.4 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, N-terminal domain Aa_trans PF01490.13 ESL09131.1 - 5.7e-52 176.5 19.7 6.8e-52 176.3 13.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL09131.1 - 3.4e-07 29.4 16.4 3.4e-07 29.4 11.4 2.1 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family CbiN PF02553.10 ESL09131.1 - 0.081 12.9 1.2 33 4.5 0.0 3.6 3 0 0 3 3 3 0 Cobalt transport protein component CbiN CH PF00307.26 ESL09133.1 - 0.0019 18.2 0.1 0.0074 16.3 0.0 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain Cyclin PF08613.6 ESL09134.1 - 6.7e-21 75.2 0.1 1.9e-20 73.7 0.1 1.8 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESL09134.1 - 0.0021 17.6 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain INCA1 PF15142.1 ESL09135.1 - 0.091 12.5 0.2 0.55 9.9 0.1 2.0 2 0 0 2 2 2 0 INCA1 Telomere_Sde2 PF13019.1 ESL09136.1 - 0.022 14.4 3.3 0.036 13.7 2.3 1.5 1 1 0 1 1 1 0 Telomere stability and silencing Adaptin_N PF01602.15 ESL09137.1 - 1.4e-78 264.5 1.0 1.7e-78 264.2 0.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region CLASP_N PF12348.3 ESL09137.1 - 0.054 12.8 0.1 5.2 6.3 0.0 2.5 2 0 0 2 2 2 0 CLASP N terminal Glyco_tran_WecB PF03808.8 ESL09137.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family DUF402 PF04167.8 ESL09138.1 - 0.062 13.1 0.1 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF402) PIF1 PF05970.9 ESL09140.1 - 1.1e-34 119.9 1.6 2.7e-28 98.9 0.2 3.3 2 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 ESL09140.1 - 1.7e-17 63.6 0.0 3.6e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL09140.1 - 5.4e-05 22.8 0.3 0.00035 20.2 0.3 2.2 2 0 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 ESL09140.1 - 0.00025 20.5 0.2 0.00078 18.8 0.2 1.8 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 ESL09140.1 - 0.0014 18.6 0.8 0.02 14.8 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.13 ESL09140.1 - 0.0016 17.9 0.1 0.93 8.9 0.0 2.6 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 ESL09140.1 - 0.0019 18.3 0.8 0.01 15.9 0.2 2.4 2 1 0 2 2 2 1 AAA domain Herpes_Helicase PF02689.9 ESL09140.1 - 0.0043 14.8 0.3 0.26 8.9 0.0 2.9 3 1 1 4 4 4 1 Helicase UvrD_C_2 PF13538.1 ESL09140.1 - 0.016 15.3 0.0 0.092 12.8 0.0 2.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF258 PF03193.11 ESL09140.1 - 0.14 11.3 0.1 0.27 10.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_11 PF13086.1 ESL09140.1 - 0.15 11.6 0.8 13 5.2 0.0 2.7 2 1 1 3 3 3 0 AAA domain zf-CCCH PF00642.19 ESL09141.1 - 4.3e-07 29.4 3.2 8.1e-07 28.5 2.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESL09141.1 - 0.16 12.0 1.9 0.39 10.8 1.3 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Hydrolase PF00702.21 ESL09142.1 - 6.9e-13 49.4 0.5 2.8e-07 31.1 0.2 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ESL09142.1 - 1.2e-11 44.0 0.0 3.6e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 ESL09142.1 - 3.1e-11 43.7 0.0 1.1e-10 41.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL09142.1 - 2.8e-09 36.8 0.0 1.7e-08 34.2 0.0 2.2 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESL09142.1 - 0.0014 18.2 0.3 0.0047 16.5 0.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DPCD PF14913.1 ESL09143.1 - 1.7e-49 167.5 0.1 2e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 DPCD protein family Sec1 PF00995.18 ESL09144.1 - 1.5e-112 377.1 0.0 1.7e-112 376.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Ank_2 PF12796.2 ESL09146.1 - 1.6e-23 82.8 1.9 2.3e-12 47.0 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESL09146.1 - 1.2e-14 53.9 0.7 2.5e-07 30.7 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESL09146.1 - 6e-14 52.1 0.3 1.4e-06 28.6 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 ESL09146.1 - 1.3e-12 46.8 0.4 4.4e-05 23.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 ESL09146.1 - 3.3e-11 42.2 0.3 0.00032 20.6 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat DUF2803 PF10972.3 ESL09146.1 - 0.045 13.2 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2803) CHORD PF04968.7 ESL09147.1 - 4.5e-45 151.7 25.4 2.4e-22 78.9 3.7 2.3 2 0 0 2 2 2 2 CHORD DUF3931 PF13082.1 ESL09147.1 - 0.13 12.1 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3931) TSP9 PF11493.3 ESL09148.1 - 0.18 12.3 1.2 0.65 10.5 0.8 1.9 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 Ycf1 PF05758.7 ESL09151.1 - 0.36 8.4 2.4 0.33 8.6 1.6 1.0 1 0 0 1 1 1 0 Ycf1 IncFII_repA PF02387.10 ESL09151.1 - 0.62 9.1 9.1 0.83 8.7 6.3 1.2 1 0 0 1 1 1 0 IncFII RepA protein family DDHD PF02862.12 ESL09151.1 - 0.67 9.7 4.2 0.74 9.5 2.9 1.1 1 0 0 1 1 1 0 DDHD domain DUF2852 PF11014.3 ESL09151.1 - 0.81 9.6 4.7 1.3 8.9 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Asp-B-Hydro_N PF05279.6 ESL09151.1 - 2.1 8.1 10.1 2.5 7.8 7.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DREPP PF05558.7 ESL09151.1 - 2.6 7.8 9.8 3.1 7.5 6.8 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Cytomega_UL84 PF06284.6 ESL09151.1 - 3.5 5.9 7.1 1.5 7.1 2.4 1.9 1 1 1 2 2 2 0 Cytomegalovirus UL84 protein Abhydrolase_6 PF12697.2 ESL09152.1 - 0.017 15.0 0.6 0.12 12.2 0.4 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF4366 PF14283.1 ESL09152.1 - 0.12 11.8 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) ADH_zinc_N PF00107.21 ESL09153.1 - 1.3e-15 57.0 0.2 3.2e-15 55.8 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESL09153.1 - 9.8e-12 45.8 0.0 2.2e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESL09153.1 - 3.6e-06 26.6 0.0 3.9e-05 23.3 0.0 2.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ArfGap PF01412.13 ESL09154.1 - 2.4e-26 91.7 0.1 7.3e-26 90.2 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Peptidase_C54 PF03416.14 ESL09155.1 - 7.9e-38 130.1 0.0 3.6e-36 124.7 0.0 2.0 1 1 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.8 ESL09155.1 - 0.013 14.5 0.2 0.17 10.9 0.1 2.0 2 0 0 2 2 2 0 Peptidase family C78 ATAD4 PF15321.1 ESL09156.1 - 2 9.4 6.4 23 6.0 1.0 3.0 3 0 0 3 3 3 0 ATPase family AAA domain containing 4 DUF1042 PF06294.6 ESL09157.1 - 3.5e-12 46.1 0.0 8.1e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 ESL09157.1 - 0.0012 18.4 0.0 0.0031 17.1 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain BDHCT PF08072.6 ESL09157.1 - 0.074 13.1 0.5 0.66 10.1 0.0 2.9 3 0 0 3 3 3 0 BDHCT (NUC031) domain Mod_r PF07200.8 ESL09158.1 - 0.19 11.6 6.1 0.24 11.2 4.3 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Cytochrom_C1 PF02167.10 ESL09159.1 - 9.4e-62 208.5 0.0 1.1e-61 208.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family TTL PF03133.10 ESL09160.1 - 2e-54 184.5 0.0 2.1e-33 115.5 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ESL09160.1 - 2.6e-06 26.4 0.0 0.0048 15.7 0.0 2.6 2 0 0 2 2 2 2 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.8 ESL09160.1 - 0.0056 16.0 0.0 0.0096 15.3 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus CP_ATPgrasp_1 PF04174.8 ESL09160.1 - 0.11 11.0 0.0 0.22 10.1 0.0 1.4 1 0 0 1 1 1 0 A circularly permuted ATPgrasp RRM_6 PF14259.1 ESL09161.1 - 6.2e-44 147.8 0.1 3.2e-15 55.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL09161.1 - 3.2e-32 109.9 0.1 2.3e-11 43.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL09161.1 - 2.1e-07 30.6 0.0 0.079 12.8 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup54 PF13874.1 ESL09161.1 - 0.029 14.0 0.3 1.2 8.7 0.4 2.5 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Peptidase_M20 PF01546.23 ESL09161.1 - 0.11 12.0 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DUF563 PF04577.9 ESL09162.1 - 8e-26 91.2 0.1 1.8e-25 90.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PSI_PsaJ PF01701.13 ESL09162.1 - 0.12 12.1 0.1 2.7 7.8 0.0 2.5 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IX / PsaJ Phosducin PF02114.11 ESL09163.1 - 0.11 11.2 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Phosducin SMC_N PF02463.14 ESL09166.1 - 3.9e-59 199.5 0.0 1.4e-58 197.7 0.0 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESL09166.1 - 3.1e-29 101.3 0.0 1.2e-28 99.4 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 ESL09166.1 - 2e-15 57.5 0.0 5e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 ESL09166.1 - 4.2e-11 43.5 12.3 4.2e-11 43.5 8.5 5.4 2 2 1 3 3 1 1 AAA domain AAA_29 PF13555.1 ESL09166.1 - 5.2e-09 35.5 0.0 1e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 ESL09166.1 - 5.7e-05 22.3 0.2 0.13 11.2 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain BRE1 PF08647.6 ESL09166.1 - 0.0077 16.1 3.1 0.0077 16.1 2.2 7.8 5 2 1 7 7 6 1 BRE1 E3 ubiquitin ligase SbcCD_C PF13558.1 ESL09166.1 - 0.01 15.7 0.0 0.04 13.8 0.0 2.1 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.22 ESL09166.1 - 0.029 14.6 0.1 0.029 14.6 0.1 5.9 3 2 2 5 5 5 0 ABC transporter AAA_25 PF13481.1 ESL09166.1 - 0.32 10.3 3.6 0.52 9.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain Reo_sigmaC PF04582.7 ESL09166.1 - 2.1 7.4 15.3 0.18 10.9 0.3 4.3 4 1 0 5 5 5 0 Reovirus sigma C capsid protein RAMP4 PF06624.7 ESL09167.1 - 1.6e-07 30.7 0.3 2.9e-07 29.9 0.2 1.4 1 1 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Ribosomal_S7e PF01251.13 ESL09168.1 - 8.1e-66 221.1 1.4 1e-65 220.8 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e AAA_19 PF13245.1 ESL09169.1 - 1.4e-05 24.7 0.4 4.5e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain KaiC PF06745.8 ESL09169.1 - 0.0041 16.2 0.0 0.0075 15.4 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_33 PF13671.1 ESL09169.1 - 0.0069 16.2 0.4 0.0069 16.2 0.3 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESL09169.1 - 0.013 14.9 0.1 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.10 ESL09169.1 - 0.015 14.2 0.0 0.026 13.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_17 PF13207.1 ESL09169.1 - 0.016 16.0 0.1 0.033 14.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESL09169.1 - 0.022 14.8 0.0 0.07 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESL09169.1 - 0.029 14.5 0.0 0.059 13.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 ESL09169.1 - 0.048 12.8 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.1 ESL09169.1 - 0.11 12.0 0.1 0.65 9.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 ESL09169.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 ESL09169.1 - 0.15 10.9 0.7 0.2 10.5 0.1 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.5 ESL09169.1 - 0.16 11.1 0.4 6.4 5.8 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Actin PF00022.14 ESL09170.1 - 7.2e-92 307.8 0.0 1.1e-91 307.2 0.0 1.2 1 0 0 1 1 1 1 Actin DUF2372 PF10178.4 ESL09171.1 - 0.00018 21.5 0.0 0.0003 20.8 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2372) Tmemb_14 PF03647.8 ESL09172.1 - 7.5e-16 58.3 10.2 9.4e-16 57.9 7.1 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF4203 PF13886.1 ESL09172.1 - 0.11 11.8 4.1 0.14 11.6 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4203) HTH_30 PF13556.1 ESL09173.1 - 0.1 12.2 0.2 0.22 11.1 0.2 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DUF3552 PF12072.3 ESL09174.1 - 0.0032 16.7 0.8 0.0052 16.0 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) CHASE3 PF05227.8 ESL09174.1 - 0.013 15.1 1.3 0.013 15.1 0.9 1.5 2 0 0 2 2 2 0 CHASE3 domain CENP-Q PF13094.1 ESL09174.1 - 0.02 14.9 2.3 0.036 14.1 1.6 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.7 ESL09174.1 - 0.049 13.9 0.8 0.11 12.9 0.5 1.6 1 0 0 1 1 1 0 SlyX Kelch_4 PF13418.1 ESL09178.1 - 1.2e-17 63.4 11.7 1.8e-06 27.5 0.1 6.5 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL09178.1 - 3e-14 52.6 16.0 0.00064 19.8 0.0 7.2 6 3 1 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL09178.1 - 3.9e-13 49.0 4.1 1.4e-05 24.8 0.1 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 ESL09178.1 - 3.1e-08 33.4 2.1 0.17 12.0 0.0 5.1 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ESL09178.1 - 1.2e-05 24.7 8.4 0.043 13.3 0.0 4.9 5 0 0 5 5 5 2 Kelch motif BNR PF02012.15 ESL09179.1 - 0.00032 20.0 6.2 3.9 7.7 0.0 4.4 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_2 PF13088.1 ESL09179.1 - 0.083 12.1 0.0 2.5 7.3 0.0 2.3 2 0 0 2 2 2 0 BNR repeat-like domain GDI PF00996.13 ESL09180.1 - 1e-172 574.4 0.0 1.2e-172 574.1 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Histone PF00125.19 ESL09181.1 - 4.1e-14 52.4 0.1 6.2e-14 51.8 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 FoP_duplication PF13865.1 ESL09181.1 - 0.42 11.0 9.0 1.1 9.8 6.3 1.7 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DUF1738 PF08401.6 ESL09182.1 - 0.0016 18.1 0.5 0.17 11.6 0.1 3.0 2 1 0 3 3 3 2 Domain of unknown function (DUF1738) NUDIX PF00293.23 ESL09183.1 - 3.1e-14 52.7 0.0 4.7e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Pet191_N PF10203.4 ESL09184.1 - 0.064 13.2 0.9 0.084 12.9 0.6 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 TatD_DNase PF01026.16 ESL09185.1 - 2e-43 148.4 0.0 2.4e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Pkinase PF00069.20 ESL09187.1 - 2.3e-63 213.7 0.0 3.5e-63 213.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09187.1 - 3.3e-48 164.0 0.0 4.6e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09187.1 - 1.6e-06 27.3 0.1 2.9e-06 26.4 0.0 1.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL09187.1 - 0.00087 19.0 2.1 0.5 10.0 0.0 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family GFA PF04828.9 ESL09187.1 - 0.0077 16.1 0.2 4.3 7.3 0.0 2.6 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme TTL PF03133.10 ESL09188.1 - 2e-45 154.9 0.0 3.3e-44 150.9 0.0 2.1 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ESL09188.1 - 0.064 12.0 0.0 0.13 11.0 0.0 1.5 1 0 0 1 1 1 0 YheC/D like ATP-grasp UCH PF00443.24 ESL09189.1 - 6.6e-40 136.9 0.0 2e-39 135.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL09189.1 - 6.2e-09 35.7 0.0 5.9e-08 32.4 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Laminin_G_3 PF13385.1 ESL09190.1 - 5.3e-06 26.7 0.0 5.8e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Colicin_M PF14859.1 ESL09190.1 - 0.088 11.6 0.0 0.088 11.6 0.0 1.1 1 0 0 1 1 1 0 Colicin M RNA_pol_L_2 PF13656.1 ESL09192.1 - 2.5e-24 84.5 0.0 3.8e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 ESL09192.1 - 1.9e-05 23.6 0.0 3.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Ribosomal_L9_N PF01281.14 ESL09193.1 - 0.00026 20.1 0.0 0.00051 19.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain DUF3586 PF12131.3 ESL09194.1 - 5.3e-24 84.0 8.4 5.3e-24 84.0 5.8 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3586) Peptidase_C1 PF00112.18 ESL09194.1 - 4.2e-22 79.1 1.4 7.5e-22 78.2 1.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 ESL09194.1 - 0.00057 18.5 0.1 0.00072 18.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase C1-like family GTP_EFTU PF00009.22 ESL09195.1 - 1.1e-61 207.5 0.2 1.8e-61 206.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESL09195.1 - 9.3e-36 122.0 0.0 2.2e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 ESL09195.1 - 3.3e-21 74.9 0.0 8.2e-21 73.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 ESL09195.1 - 7e-14 51.4 0.1 2.3e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESL09195.1 - 6.3e-13 48.6 0.1 2.1e-12 46.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Asp_protease PF09668.5 ESL09196.1 - 1.4e-52 176.4 0.5 2.3e-52 175.7 0.3 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 ESL09196.1 - 6e-09 36.2 0.1 1.5e-08 34.9 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease UBA_4 PF14555.1 ESL09196.1 - 1e-06 28.1 0.0 2.1e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain gag-asp_proteas PF13975.1 ESL09196.1 - 1.2e-06 28.2 0.0 3.3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Rad60-SLD PF11976.3 ESL09196.1 - 0.00018 21.0 0.0 0.00031 20.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP_2 PF08284.6 ESL09196.1 - 0.00042 20.2 0.2 0.00075 19.4 0.1 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 ESL09196.1 - 0.00098 19.0 0.3 0.0044 16.9 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease ubiquitin PF00240.18 ESL09196.1 - 0.02 14.2 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family UPF0126 PF03458.8 ESL09197.1 - 3.3 7.3 9.0 1.8 8.2 0.9 3.4 3 0 0 3 3 3 0 UPF0126 domain Las1 PF04031.8 ESL09199.1 - 8.4e-37 126.2 0.0 1.3e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Las1-like Reo_sigmaC PF04582.7 ESL09200.1 - 0.025 13.7 37.4 0.03 13.5 5.1 5.3 3 1 2 6 6 6 0 Reovirus sigma C capsid protein PPR_3 PF13812.1 ESL09203.1 - 0.36 11.2 4.3 4 7.9 0.0 4.5 6 0 0 6 6 6 0 Pentatricopeptide repeat domain UDP-g_GGTase PF06427.6 ESL09205.1 - 6.2e-57 192.3 0.0 5.2e-55 186.0 0.0 2.3 2 0 0 2 2 2 2 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 ESL09205.1 - 0.00027 20.3 0.0 0.00051 19.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Pkinase PF00069.20 ESL09206.1 - 3.8e-54 183.5 0.0 4.6e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09206.1 - 7.4e-27 94.0 0.0 9.6e-27 93.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09206.1 - 2.5e-07 29.9 0.0 7.1e-07 28.4 0.0 1.7 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESL09206.1 - 0.0017 17.4 0.0 0.0025 16.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL09206.1 - 0.015 15.0 1.5 1.1 8.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family PBP PF01161.15 ESL09206.1 - 0.093 12.5 0.1 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein Nop14 PF04147.7 ESL09207.1 - 0.12 10.2 16.9 0.17 9.7 11.7 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 ESL09207.1 - 0.39 9.1 17.6 0.52 8.7 12.2 1.1 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESL09207.1 - 0.57 8.1 7.3 0.75 7.7 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.7 ESL09207.1 - 4.7 6.4 17.4 6.4 5.9 12.0 1.1 1 0 0 1 1 1 0 SDA1 Pox_Ag35 PF03286.9 ESL09207.1 - 9.9 5.6 7.3 22 4.5 5.0 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Med30 PF11315.3 ESL09208.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Mediator complex subunit 30 Toxin_43 PF15604.1 ESL09208.1 - 0.25 11.3 2.6 0.2 11.6 0.2 2.0 2 0 0 2 2 2 0 Putative toxin 43 PALP PF00291.20 ESL09209.1 - 6.7e-46 156.9 0.0 7.7e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme FAD_binding_2 PF00890.19 ESL09209.1 - 0.21 10.3 2.0 2.3 6.9 0.6 2.0 2 0 0 2 2 2 0 FAD binding domain Ribosomal_L10 PF00466.15 ESL09212.1 - 3.4e-25 87.8 0.2 6.6e-25 86.9 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 ESL09212.1 - 4.2e-16 59.1 10.7 4.2e-16 59.1 7.4 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein DUF4233 PF14017.1 ESL09214.1 - 0.22 11.4 4.5 0.085 12.7 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4233) Hydrolase_6 PF13344.1 ESL09215.1 - 1.1e-19 70.1 0.0 1.9e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESL09215.1 - 1.6e-10 40.5 0.0 3.6e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like DUF4121 PF13497.1 ESL09215.1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) Prefoldin_2 PF01920.15 ESL09217.1 - 0.096 12.4 0.0 0.096 12.4 0.0 4.0 3 1 0 4 4 4 0 Prefoldin subunit WD40 PF00400.27 ESL09218.1 - 0.015 15.1 4.3 7.7 6.5 0.0 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat Mito_carr PF00153.22 ESL09219.1 - 4.7e-40 135.2 5.2 1.5e-14 53.4 0.2 4.2 3 3 0 3 3 3 3 Mitochondrial carrier protein Seryl_tRNA_N PF02403.17 ESL09220.1 - 0.0062 16.5 5.0 0.0062 16.5 3.5 8.5 4 3 4 8 8 8 4 Seryl-tRNA synthetase N-terminal domain WD40 PF00400.27 ESL09221.1 - 5.2e-07 29.3 1.2 0.016 15.1 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat LisH PF08513.6 ESL09221.1 - 7.9e-05 22.2 3.0 0.0043 16.7 0.3 2.4 2 0 0 2 2 2 2 LisH BBS2_Mid PF14783.1 ESL09221.1 - 0.048 13.4 0.0 0.35 10.6 0.0 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Ribosomal_L32e PF01655.13 ESL09223.1 - 5.3e-24 84.3 0.1 6e-24 84.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 DUF1436 PF07262.6 ESL09223.1 - 0.027 13.9 0.1 0.027 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) ARPC4 PF05856.7 ESL09224.1 - 3.4e-68 228.3 0.2 3.8e-68 228.1 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) MMPL PF03176.10 ESL09225.1 - 2.8e-55 187.3 12.8 2.7e-33 115.0 1.4 2.5 2 0 0 2 2 2 2 MMPL family PB1 PF00564.19 ESL09226.1 - 2.6e-07 30.2 0.0 6.8e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 PB1 domain eRF1_1 PF03463.10 ESL09227.1 - 4.7e-34 116.8 2.3 7.2e-34 116.2 0.7 1.8 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_3 PF03465.10 ESL09227.1 - 7e-16 58.4 0.0 5.1e-15 55.7 0.0 2.3 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.10 ESL09227.1 - 9.8e-16 58.2 0.0 1.4e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 Bromodomain PF00439.20 ESL09228.1 - 3e-17 62.3 0.0 9.1e-10 38.3 0.0 2.7 2 1 0 2 2 2 2 Bromodomain DUF3909 PF13077.1 ESL09228.1 - 0.078 12.8 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3909) Reo_sigmaC PF04582.7 ESL09229.1 - 1.9 7.5 7.3 1.2 8.2 0.9 2.5 1 1 3 4 4 4 0 Reovirus sigma C capsid protein NAD_binding_1 PF00175.16 ESL09230.1 - 6.4e-23 81.4 0.0 1e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL09230.1 - 5.1e-14 52.1 0.0 8e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESL09230.1 - 1.2e-05 25.2 0.0 5.8e-05 23.0 0.0 1.9 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Acyltransferase PF01553.16 ESL09234.1 - 7.1e-11 41.6 0.4 3.4e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 Acyltransferase DUF2085 PF09858.4 ESL09234.1 - 0.019 15.0 0.6 0.037 14.0 0.4 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2085) Dispanin PF04505.7 ESL09234.1 - 0.32 10.5 2.3 12 5.5 0.1 2.7 2 0 0 2 2 2 0 Interferon-induced transmembrane protein RRF PF01765.14 ESL09235.1 - 1.9e-16 59.9 3.6 3.2e-16 59.2 2.5 1.3 1 0 0 1 1 1 1 Ribosome recycling factor E1_dh PF00676.15 ESL09235.1 - 0.0071 15.1 0.0 0.011 14.4 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Methyltransf_2 PF00891.13 ESL09235.1 - 0.027 13.6 0.1 0.054 12.6 0.0 1.6 1 1 1 2 2 2 0 O-methyltransferase TMPIT PF07851.8 ESL09235.1 - 0.035 13.1 0.9 0.06 12.4 0.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF29 PF01724.11 ESL09235.1 - 0.091 12.5 0.9 0.14 11.9 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF29 GlutR_dimer PF00745.15 ESL09235.1 - 0.17 11.8 4.9 0.063 13.2 1.3 1.7 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain DNA_pol_B PF00136.16 ESL09236.1 - 6.6e-139 463.6 0.0 9.1e-139 463.2 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESL09236.1 - 2.6e-73 246.7 0.0 4.4e-73 245.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 ESL09236.1 - 7.4e-22 77.1 9.5 1.8e-21 75.9 6.6 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.4 ESL09236.1 - 0.029 13.9 0.0 0.059 12.9 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 ESL09236.1 - 0.15 11.8 0.2 0.66 9.7 0.1 2.0 1 1 0 1 1 1 0 RNase_H superfamily DNA_pol_B_2 PF03175.8 ESL09236.1 - 0.27 9.8 0.1 0.92 8.1 0.0 2.0 3 0 0 3 3 3 0 DNA polymerase type B, organellar and viral zf-RING-like PF08746.6 ESL09236.1 - 1.3 9.0 9.1 11 6.0 1.4 3.0 2 0 0 2 2 2 0 RING-like domain Ribosomal_S4 PF00163.14 ESL09238.1 - 1.2e-27 96.1 0.5 1.2e-27 96.1 0.3 1.6 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 ESL09238.1 - 7.6e-13 47.6 0.4 1.7e-12 46.5 0.3 1.6 1 0 0 1 1 1 1 S4 domain AAA_16 PF13191.1 ESL09239.1 - 2.3e-05 24.4 2.2 5.4e-05 23.2 0.5 2.5 2 1 0 2 2 2 1 AAA ATPase domain MCM PF00493.18 ESL09239.1 - 9.8e-05 21.2 0.0 0.00017 20.4 0.0 1.3 1 0 0 1 1 1 1 MCM2/3/5 family G-alpha PF00503.15 ESL09239.1 - 0.0016 17.1 0.0 0.0024 16.6 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit FtsK_SpoIIIE PF01580.13 ESL09239.1 - 0.06 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 ESL09239.1 - 0.086 12.3 0.1 0.33 10.5 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain Arch_ATPase PF01637.13 ESL09239.1 - 0.25 11.0 0.0 0.41 10.3 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase zf-NF-X1 PF01422.12 ESL09241.1 - 1.3e-12 47.3 84.0 8e-07 28.8 9.5 13.6 15 0 0 15 15 15 6 NF-X1 type zinc finger DUF543 PF04418.7 ESL09242.1 - 6.7e-19 67.6 1.0 8.6e-19 67.2 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF543) ADK PF00406.17 ESL09243.1 - 2.7e-38 131.1 0.0 3.2e-38 130.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESL09243.1 - 1.7e-08 35.2 0.0 2.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL09243.1 - 2.8e-08 33.7 0.1 1.8e-07 31.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL09243.1 - 2.8e-08 34.1 0.0 4.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL09243.1 - 0.00095 18.3 0.1 0.0023 17.0 0.1 1.8 1 1 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.12 ESL09243.1 - 0.0018 17.6 0.0 0.32 10.3 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase AAA_19 PF13245.1 ESL09243.1 - 0.011 15.4 0.1 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain CoaE PF01121.15 ESL09243.1 - 0.051 12.9 0.0 0.8 9.0 0.0 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase DUF2075 PF09848.4 ESL09243.1 - 0.15 11.0 0.1 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_pol_Rpc34 PF05158.7 ESL09245.1 - 6.2e-85 285.2 0.0 7e-85 285.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.6 ESL09245.1 - 0.0054 17.1 0.6 6.1 7.3 0.0 2.9 3 1 1 4 4 4 2 Replication protein A C terminal HTH_27 PF13463.1 ESL09245.1 - 0.0086 16.3 0.2 1.4 9.2 0.0 2.4 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_20 PF12840.2 ESL09245.1 - 0.015 15.0 0.2 0.26 11.1 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.2 ESL09245.1 - 0.022 14.3 2.1 0.45 10.2 0.2 2.5 2 0 0 2 2 2 0 MarR family DUF1771 PF08590.5 ESL09246.1 - 0.053 13.5 1.1 0.3 11.1 0.8 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) DUF677 PF05055.7 ESL09246.1 - 0.3 9.7 1.9 1.4 7.5 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF677) zf-RanBP PF00641.13 ESL09247.1 - 1e-06 27.7 3.3 1.6e-06 27.1 2.3 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Aldolase_II PF00596.16 ESL09247.1 - 0.024 14.2 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain DUF148 PF02520.12 ESL09248.1 - 0.033 13.9 17.1 0.19 11.5 4.3 2.4 1 1 1 2 2 2 0 Domain of unknown function DUF148 NPV_P10 PF05531.7 ESL09248.1 - 0.033 14.4 8.0 5.4 7.3 0.1 3.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.3 ESL09248.1 - 0.37 8.0 30.8 0.54 7.5 21.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PhoU PF01895.14 ESL09248.1 - 1.6 9.2 6.9 2.2 8.7 1.9 2.4 2 0 0 2 2 2 0 PhoU domain DUF3140 PF11338.3 ESL09248.1 - 2.9 8.0 8.0 0.67 10.1 1.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3140) TPR_MLP1_2 PF07926.7 ESL09248.1 - 5.2 6.8 35.0 1.6 8.4 14.2 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ERM PF00769.14 ESL09248.1 - 7 6.0 36.7 53 3.2 12.7 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family RNase_Zc3h12a PF11977.3 ESL09248.1 - 7.1 6.4 7.6 13 5.6 1.5 2.2 1 1 1 2 2 2 0 Zc3h12a-like Ribonuclease NYN domain TMPIT PF07851.8 ESL09248.1 - 9.7 5.1 16.4 0.92 8.5 4.6 2.2 1 1 1 2 2 2 0 TMPIT-like protein zf-C4H2 PF10146.4 ESL09248.1 - 9.8 6.1 21.9 17 5.3 15.2 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein VPS9 PF02204.13 ESL09250.1 - 9.8e-07 28.7 0.0 0.00012 22.0 0.0 2.5 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain Kinesin PF00225.18 ESL09251.1 - 1.6e-76 257.1 0.0 2e-76 256.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain DUF4140 PF13600.1 ESL09251.1 - 0.0099 16.3 0.1 0.024 15.0 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of unknown function (DUF4140) DUF3525 PF12039.3 ESL09251.1 - 0.053 12.0 0.0 0.088 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) TSC22 PF01166.13 ESL09251.1 - 0.081 12.9 0.1 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family bZIP_2 PF07716.10 ESL09251.1 - 0.13 12.0 5.0 0.25 11.1 3.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper OB_NTP_bind PF07717.11 ESL09252.1 - 8e-14 51.4 0.0 1.2e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DUF2867 PF11066.3 ESL09252.1 - 0.081 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) CactinC_cactus PF09732.4 ESL09253.1 - 1.1e-41 141.3 1.5 1.7e-41 140.7 1.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DM13 PF10517.4 ESL09255.1 - 0.077 13.3 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 Electron transfer DM13 BicD PF09730.4 ESL09256.1 - 5.9 5.1 15.3 6.9 4.8 10.6 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D UQ_con PF00179.21 ESL09258.1 - 5.5e-41 139.2 0.0 6e-41 139.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESL09258.1 - 0.086 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Aph-1 PF06105.7 ESL09259.1 - 7.6e-07 28.6 11.1 7.6e-07 28.6 7.7 1.8 2 0 0 2 2 2 1 Aph-1 protein Ndc1_Nup PF09531.5 ESL09259.1 - 3.2 6.0 7.0 7 4.9 4.8 1.6 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DnaJ PF00226.26 ESL09260.1 - 7e-10 38.5 0.0 1.2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Nop10p PF04135.7 ESL09261.1 - 1.6e-21 75.7 0.4 1.7e-21 75.6 0.3 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family 6PF2K PF01591.13 ESL09262.1 - 2.1e-20 72.7 1.9 1.4e-12 47.1 0.0 3.1 2 1 0 3 3 3 3 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 ESL09262.1 - 3.6e-09 36.8 0.0 9.1e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 ESL09262.1 - 0.0016 18.3 0.0 0.0045 16.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09262.1 - 0.0025 18.5 0.0 0.0084 16.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain MAGE_N PF12440.3 ESL09262.1 - 0.059 13.6 0.5 0.059 13.6 0.4 2.5 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal DUF2664 PF10867.3 ESL09264.1 - 0.099 13.2 3.1 0.24 12.0 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) Methyltransf_26 PF13659.1 ESL09265.1 - 5.4e-05 23.2 0.9 8.7e-05 22.5 0.3 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL09265.1 - 0.00037 20.8 0.0 0.00054 20.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL09265.1 - 0.0017 17.9 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL09265.1 - 0.016 15.7 0.0 0.037 14.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain CheR PF01739.13 ESL09265.1 - 0.053 12.8 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.1 ESL09265.1 - 0.083 12.5 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESL09265.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 ESL09265.1 - 0.14 12.6 0.0 1 9.8 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain PP2C PF00481.16 ESL09266.1 - 4.9e-47 160.4 0.0 7.5e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 ESL09266.1 - 7.5e-05 22.5 0.0 0.00065 19.4 0.0 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESL09266.1 - 0.0038 16.6 0.2 0.044 13.1 0.0 2.7 1 1 1 2 2 2 1 Protein phosphatase 2C Pkinase PF00069.20 ESL09267.1 - 2e-21 76.3 0.1 1.7e-10 40.4 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09267.1 - 1.3e-20 73.6 0.0 5.5e-10 38.7 0.0 3.3 3 0 0 3 3 3 2 Protein tyrosine kinase Vps51 PF08700.6 ESL09269.1 - 2.1e-26 91.5 4.5 3e-25 87.8 1.5 2.9 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.1 ESL09269.1 - 1.9e-15 57.0 1.8 4.3e-15 55.9 1.3 1.6 1 0 0 1 1 1 1 Exocyst complex component Sec5 Dor1 PF04124.7 ESL09269.1 - 1.4e-07 30.2 7.1 1.4e-07 30.2 4.9 2.6 3 0 0 3 3 3 1 Dor1-like family COG2 PF06148.6 ESL09269.1 - 2.1e-07 30.8 4.8 6.4e-07 29.2 3.3 1.8 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF2450 PF10475.4 ESL09269.1 - 3.9e-06 25.9 6.9 7.7e-06 25.0 4.8 1.4 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Vps53_N PF04100.7 ESL09269.1 - 2e-05 23.5 5.2 2e-05 23.5 3.6 1.5 2 0 0 2 2 2 1 Vps53-like, N-terminal COG5 PF10392.4 ESL09269.1 - 2.4e-05 24.2 5.5 7.3e-05 22.7 3.8 1.8 1 0 0 1 1 1 1 Golgi transport complex subunit 5 BLOC1_2 PF10046.4 ESL09269.1 - 0.011 15.8 1.5 0.05 13.7 1.1 2.1 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.4 ESL09269.1 - 0.025 14.4 7.6 0.057 13.2 5.3 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.7 ESL09269.1 - 0.04 13.7 1.7 0.1 12.4 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF342 PF03961.8 ESL09269.1 - 0.052 11.9 0.3 0.085 11.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) NPV_P10 PF05531.7 ESL09269.1 - 0.11 12.6 1.2 0.35 11.1 0.2 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlgN PF05130.7 ESL09269.1 - 2.5 8.3 7.8 1.4 9.2 2.4 2.6 2 1 1 3 3 3 0 FlgN protein SCAMP PF04144.8 ESL09271.1 - 4.1e-48 163.5 9.7 4.8e-48 163.3 6.7 1.0 1 0 0 1 1 1 1 SCAMP family DUF1129 PF06570.6 ESL09271.1 - 0.0045 16.3 1.6 0.0062 15.8 0.7 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1129) zf-RING_2 PF13639.1 ESL09272.1 - 2.8e-07 30.2 6.2 4.3e-06 26.4 2.2 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESL09272.1 - 2.9e-07 30.0 2.6 2.9e-07 30.0 1.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL09272.1 - 0.00013 21.9 4.0 0.00013 21.9 2.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL09272.1 - 0.00019 21.1 5.4 0.00062 19.4 2.3 2.7 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL09272.1 - 0.00036 20.1 5.3 0.00089 18.8 1.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Tropomyosin PF00261.15 ESL09272.1 - 0.00074 18.6 2.7 0.001 18.2 1.9 1.1 1 0 0 1 1 1 1 Tropomyosin Baculo_IE-1 PF05290.6 ESL09272.1 - 0.0024 17.6 0.3 0.0055 16.4 0.2 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-Apc11 PF12861.2 ESL09272.1 - 0.0056 16.4 0.8 0.013 15.2 0.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESL09272.1 - 0.033 14.2 1.4 0.033 14.2 1.0 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger Nsp1_C PF05064.8 ESL09272.1 - 0.27 10.8 5.1 0.71 9.5 3.3 1.7 1 1 1 2 2 2 0 Nsp1-like C-terminal region Spc7 PF08317.6 ESL09272.1 - 0.95 8.0 4.7 1.3 7.5 3.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.7 ESL09272.1 - 0.99 9.1 6.7 0.48 10.1 0.2 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.1 ESL09272.1 - 2.5 8.0 8.5 35 4.3 5.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) FliX PF10768.4 ESL09272.1 - 8.1 6.6 9.5 2.7 8.2 2.4 2.4 1 1 1 2 2 2 0 Class II flagellar assembly regulator 6PF2K PF01591.13 ESL09275.1 - 2e-66 223.2 0.0 3.1e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Ank_2 PF12796.2 ESL09275.1 - 1e-14 54.6 0.0 2.2e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESL09275.1 - 2.6e-14 52.2 0.6 1.3e-08 34.1 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESL09275.1 - 5.7e-13 48.9 1.1 6.2e-07 29.7 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL09275.1 - 2.5e-10 40.2 0.3 5.5e-07 29.6 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL09275.1 - 1.8e-09 36.9 0.1 0.00022 21.1 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat AAA_33 PF13671.1 ESL09275.1 - 1.3e-07 31.5 0.0 3.1e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09275.1 - 0.00011 22.9 0.0 0.00025 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESL09275.1 - 0.002 17.4 0.0 0.0035 16.5 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 His_Phos_1 PF00300.17 ESL09275.1 - 0.0039 17.2 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Zeta_toxin PF06414.7 ESL09275.1 - 0.021 13.9 0.0 0.045 12.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.9 ESL09275.1 - 0.022 14.4 0.0 0.052 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.15 ESL09275.1 - 0.022 14.3 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.24 ESL09275.1 - 0.11 12.7 0.0 0.3 11.2 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Beta_helix PF13229.1 ESL09276.1 - 1.7e-08 34.3 0.5 0.027 14.2 1.7 3.7 2 1 1 3 3 3 3 Right handed beta helix region HCNGP PF07818.8 ESL09277.1 - 0.015 15.3 0.1 0.022 14.7 0.1 1.2 1 0 0 1 1 1 0 HCNGP-like protein TFIID-18kDa PF02269.11 ESL09277.1 - 0.039 13.7 0.4 0.066 13.0 0.3 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit FixQ PF05545.6 ESL09277.1 - 0.11 12.1 2.5 0.25 11.0 1.7 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ ABC_tran PF00005.22 ESL09278.1 - 3e-49 166.8 0.7 9.5e-24 84.2 0.0 3.6 3 0 0 3 3 3 2 ABC transporter ABC_tran_2 PF12848.2 ESL09278.1 - 1e-24 86.1 6.7 1e-24 86.1 4.7 3.6 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.1 ESL09278.1 - 2.9e-19 70.1 6.3 2e-06 28.0 0.4 4.4 3 1 1 4 4 4 4 AAA domain SMC_N PF02463.14 ESL09278.1 - 2e-08 33.7 2.6 0.012 14.8 0.0 4.2 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESL09278.1 - 9.1e-07 28.3 0.2 0.031 13.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 ESL09278.1 - 4.4e-06 27.5 0.4 0.0018 19.0 0.0 3.7 3 1 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.18 ESL09278.1 - 6e-06 26.2 0.1 0.039 13.8 0.0 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase DUF258 PF03193.11 ESL09278.1 - 3.7e-05 22.9 0.0 0.22 10.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 ESL09278.1 - 0.00014 22.3 0.0 0.088 13.3 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 ESL09278.1 - 0.00025 21.0 8.2 0.0043 17.0 0.6 3.2 2 2 1 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.1 ESL09278.1 - 0.001 18.9 0.4 0.14 12.1 0.1 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.1 ESL09278.1 - 0.0013 18.6 9.1 0.4 10.5 0.1 4.3 5 1 0 5 5 4 2 AAA domain AAA_23 PF13476.1 ESL09278.1 - 0.0016 18.8 0.5 0.0073 16.6 0.1 4.3 5 0 0 5 5 5 2 AAA domain AAA_30 PF13604.1 ESL09278.1 - 0.0025 17.4 0.0 0.67 9.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 ESL09278.1 - 0.0038 16.1 0.0 1.3 7.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NACHT PF05729.7 ESL09278.1 - 0.0052 16.4 0.0 0.52 9.9 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Dynamin_N PF00350.18 ESL09278.1 - 0.0054 16.5 1.7 3.8 7.2 0.0 3.9 4 1 1 5 5 5 1 Dynamin family AAA_22 PF13401.1 ESL09278.1 - 0.0084 16.2 2.7 0.31 11.1 0.1 3.6 2 2 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 ESL09278.1 - 0.0099 15.3 0.1 3.3 7.1 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family cobW PF02492.14 ESL09278.1 - 0.01 15.2 0.0 0.45 9.9 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 ESL09278.1 - 0.011 14.5 2.0 0.61 8.8 0.0 2.8 3 0 0 3 3 3 0 ArgK protein AAA_25 PF13481.1 ESL09278.1 - 0.014 14.7 0.0 2.8 7.2 0.0 2.9 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESL09278.1 - 0.016 14.9 0.0 0.52 10.0 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 ESL09278.1 - 0.016 15.0 0.0 11 5.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.4 ESL09278.1 - 0.023 14.1 0.1 0.16 11.4 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 ESL09278.1 - 0.027 14.4 0.1 0.027 14.4 0.0 3.3 4 0 0 4 4 3 0 AAA domain RNA_helicase PF00910.17 ESL09278.1 - 0.032 14.4 0.0 17 5.5 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_15 PF13175.1 ESL09278.1 - 0.05 12.6 8.6 0.73 8.8 0.0 4.2 3 1 1 4 4 4 0 AAA ATPase domain AAA PF00004.24 ESL09278.1 - 0.051 13.7 1.4 0.59 10.3 0.0 3.2 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESL09278.1 - 0.075 13.3 0.0 0.075 13.3 0.0 4.0 5 0 0 5 5 4 0 AAA domain ATP-synt_ab PF00006.20 ESL09278.1 - 0.085 12.3 0.0 0.68 9.3 0.0 2.4 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF87 PF01935.12 ESL09278.1 - 0.14 11.9 7.6 12 5.6 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function DUF87 TroA PF01297.12 ESL09278.1 - 0.25 10.5 1.3 0.45 9.7 0.9 1.5 1 1 0 1 1 1 0 Periplasmic solute binding protein family HATPase_c_3 PF13589.1 ESL09278.1 - 0.57 9.8 3.3 0.41 10.2 0.3 2.2 3 0 0 3 3 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_13 PF13166.1 ESL09278.1 - 1.3 7.3 11.1 0.19 10.1 0.0 3.3 4 1 0 4 4 4 0 AAA domain AAA_10 PF12846.2 ESL09278.1 - 2.7 7.3 7.9 5.5 6.3 0.0 3.7 4 1 1 5 5 4 0 AAA-like domain Tctex-1 PF03645.8 ESL09280.1 - 1.4e-24 85.8 0.0 1.7e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Prefoldin PF02996.12 ESL09281.1 - 2e-09 37.1 0.0 3.4e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.1 ESL09281.1 - 0.00015 21.4 4.7 0.03 14.0 0.2 2.3 2 0 0 2 2 2 2 Prefoldin subunit DUF1819 PF08849.6 ESL09281.1 - 0.17 11.2 0.1 0.17 11.2 0.1 2.3 3 0 0 3 3 3 0 Putative inner membrane protein (DUF1819) EF-hand_7 PF13499.1 ESL09281.1 - 0.63 10.2 3.1 0.9 9.7 0.2 2.2 2 0 0 2 2 2 0 EF-hand domain pair zf-Di19 PF05605.7 ESL09284.1 - 2.7e-13 49.7 36.7 0.00042 20.3 3.3 7.3 7 0 0 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESL09284.1 - 4.7e-11 42.3 62.3 0.0052 17.0 0.1 9.3 10 0 0 10 10 9 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESL09284.1 - 1.2e-09 37.8 56.4 0.014 15.7 0.2 9.3 10 0 0 10 10 9 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESL09284.1 - 1.9e-09 37.4 40.7 0.0012 18.8 0.0 7.1 9 0 0 9 9 7 4 Zinc-finger double-stranded RNA-binding DUF629 PF04780.7 ESL09284.1 - 1.1e-06 27.4 20.1 0.12 10.8 0.0 5.6 5 1 1 6 6 6 4 Protein of unknown function (DUF629) zf-met PF12874.2 ESL09284.1 - 1.7e-05 24.8 36.9 0.0017 18.4 0.0 7.7 10 0 0 10 10 9 4 Zinc-finger of C2H2 type zf-met2 PF12907.2 ESL09284.1 - 0.0001 22.1 29.0 0.0036 17.2 0.1 6.9 6 1 1 7 7 6 2 Zinc-binding zf-C2H2_2 PF12756.2 ESL09284.1 - 0.00013 21.9 29.8 0.32 11.1 0.2 6.9 3 2 0 4 4 4 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 ESL09284.1 - 0.00032 20.4 26.3 0.14 12.1 0.1 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger DUF3505 PF12013.3 ESL09284.1 - 0.02 15.1 26.0 0.13 12.5 1.0 5.7 2 1 4 6 6 6 0 Protein of unknown function (DUF3505) zf-H2C2_2 PF13465.1 ESL09284.1 - 0.037 14.3 0.6 0.037 14.3 0.4 8.6 8 2 0 8 8 8 0 Zinc-finger double domain Rad50_zn_hook PF04423.9 ESL09284.1 - 1.2 8.6 5.4 57 3.2 0.0 4.0 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-C2HC_2 PF13913.1 ESL09284.1 - 1.2 8.9 13.9 4.7 7.0 0.1 5.1 5 0 0 5 5 5 0 zinc-finger of a C2HC-type GAGA PF09237.6 ESL09284.1 - 5.8 6.5 11.9 6.6 6.4 0.1 4.2 5 0 0 5 5 5 0 GAGA factor CBS PF00571.23 ESL09285.1 - 4.7e-09 35.8 3.6 3.3e-07 29.9 0.5 2.3 2 0 0 2 2 2 2 CBS domain Pkinase PF00069.20 ESL09287.1 - 3.7e-72 242.6 0.0 4.6e-72 242.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09287.1 - 1.1e-28 100.0 0.0 1.4e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 ESL09287.1 - 6.9e-10 39.0 0.1 1.5e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESL09287.1 - 0.0035 17.5 3.9 0.067 13.4 2.7 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain Kdo PF06293.9 ESL09287.1 - 0.011 14.7 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL09287.1 - 0.015 14.2 0.0 0.03 13.2 0.0 1.5 1 1 0 1 1 1 0 Kinase-like PH_8 PF15409.1 ESL09287.1 - 0.026 14.5 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain YrbL-PhoP_reg PF10707.4 ESL09287.1 - 0.12 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL JCAD PF15351.1 ESL09288.1 - 0.12 10.0 0.0 0.15 9.6 0.0 1.1 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease RF-1 PF00472.15 ESL09289.1 - 1.1e-14 54.1 0.3 1.6e-14 53.6 0.2 1.2 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.4 ESL09289.1 - 0.0018 18.3 0.0 0.0028 17.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein DSS1_SEM1 PF05160.8 ESL09290.1 - 0.028 14.2 4.8 0.028 14.2 3.3 2.3 2 0 0 2 2 2 0 DSS1/SEM1 family LRS4 PF10422.4 ESL09290.1 - 0.053 12.8 0.5 0.088 12.1 0.0 1.5 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 Fip1 PF05182.8 ESL09291.1 - 1.9e-20 71.8 0.8 2.8e-20 71.3 0.5 1.3 1 0 0 1 1 1 1 Fip1 motif zf-CCCH PF00642.19 ESL09291.1 - 3.4e-06 26.5 1.5 6.4e-06 25.7 1.0 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1363 PF07101.6 ESL09291.1 - 0.049 13.7 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1363) RepB-RCR_reg PF10723.4 ESL09292.1 - 0.034 13.8 1.0 0.072 12.8 0.7 1.5 1 0 0 1 1 1 0 Replication regulatory protein RepB Peptidase_C15 PF01470.12 ESL09293.1 - 9.6e-08 32.1 0.0 0.0048 16.7 0.0 2.2 2 0 0 2 2 2 2 Pyroglutamyl peptidase DUF1016 PF06250.6 ESL09294.1 - 0.013 14.4 1.5 0.021 13.7 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1016) KOW PF00467.24 ESL09294.1 - 0.051 13.3 2.4 0.12 12.1 1.7 1.6 1 0 0 1 1 1 0 KOW motif FOLN PF09289.5 ESL09295.1 - 0.055 13.3 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Follistatin/Osteonectin-like EGF domain MatE PF01554.13 ESL09296.1 - 2.5e-39 134.5 27.3 1.8e-22 79.6 7.9 2.3 2 0 0 2 2 2 2 MatE CorA PF01544.13 ESL09296.1 - 2.3 7.1 5.6 3.9 6.4 3.9 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein GST_C_2 PF13410.1 ESL09297.1 - 5.5e-09 35.7 0.1 1.6e-08 34.3 0.1 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESL09297.1 - 4.3e-06 27.1 0.0 1.1e-05 25.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Nup35_RRM_2 PF14605.1 ESL09297.1 - 0.028 14.1 0.0 0.082 12.6 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif GST_C PF00043.20 ESL09297.1 - 0.09 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glyco_transf_25 PF01755.12 ESL09298.1 - 9.5e-19 67.8 0.0 1.1e-16 61.1 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) WD40 PF00400.27 ESL09299.1 - 0.001 18.8 13.5 0.03 14.1 0.0 7.0 8 0 0 8 8 8 2 WD domain, G-beta repeat TBCC PF07986.7 ESL09302.1 - 3.2e-34 116.9 0.1 5.5e-34 116.1 0.1 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C FOP_dimer PF09398.5 ESL09302.1 - 4.3e-07 29.8 0.0 8.3e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 FOP N terminal dimerisation domain CAP_C PF08603.6 ESL09302.1 - 0.032 13.5 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal Got1 PF04178.7 ESL09304.1 - 2.4e-31 108.2 17.9 4.3e-31 107.4 12.4 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family DUF4064 PF13273.1 ESL09304.1 - 1.6 8.8 5.4 4.8 7.3 3.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) FKBP_C PF00254.23 ESL09306.1 - 5.1e-24 84.1 0.0 7.8e-24 83.5 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 ESL09306.1 - 0.029 14.4 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PGM_PMM_II PF02879.11 ESL09307.1 - 0.0012 19.0 0.0 0.0025 18.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II SET PF00856.23 ESL09307.1 - 0.0067 16.7 0.2 0.043 14.1 0.0 2.1 2 0 0 2 2 2 1 SET domain RNA_pol_Rpb8 PF03870.10 ESL09309.1 - 8.4e-27 94.0 0.0 9.4e-27 93.8 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 TRAP-delta PF05404.7 ESL09309.1 - 0.0065 15.9 0.0 0.0077 15.7 0.0 1.2 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) End_beta_barrel PF12195.3 ESL09309.1 - 0.067 12.9 0.3 8.6 6.1 0.0 2.2 1 1 1 2 2 2 0 Beta barrel domain of bacteriophage endosialidase TBCC PF07986.7 ESL09310.1 - 1.4e-19 69.6 18.8 1.3e-11 43.9 0.6 2.8 3 0 0 3 3 3 2 Tubulin binding cofactor C CAP_C PF08603.6 ESL09310.1 - 0.25 10.6 3.1 0.2 11.0 0.2 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) C terminal DUF4148 PF13663.1 ESL09310.1 - 2 8.2 4.6 8.4 6.3 0.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4148) Adaptin_N PF01602.15 ESL09311.1 - 1.3e-75 254.7 0.5 1.8e-75 254.2 0.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.1 ESL09311.1 - 7.6e-12 45.3 0.0 1.8e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform HEAT_2 PF13646.1 ESL09311.1 - 2.5e-08 34.0 3.6 0.11 12.7 0.0 4.6 4 1 0 4 4 4 3 HEAT repeats Cnd1 PF12717.2 ESL09311.1 - 2.7e-07 30.6 0.2 0.0024 17.7 0.2 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 ESL09311.1 - 0.00015 21.5 3.3 0.73 10.0 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.1 ESL09311.1 - 0.00071 19.9 2.8 4.7 7.8 0.0 4.6 4 0 0 4 4 4 2 HEAT-like repeat Cnd3 PF12719.2 ESL09311.1 - 0.078 11.9 2.2 0.14 11.1 0.2 2.3 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Melibiase PF02065.13 ESL09311.1 - 0.085 11.5 0.1 0.17 10.5 0.1 1.4 1 0 0 1 1 1 0 Melibiase Vps35 PF03635.12 ESL09312.1 - 4.4e-240 798.9 0.2 5.1e-240 798.7 0.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Tenui_NCP PF04876.7 ESL09312.1 - 0.0024 17.4 0.5 0.24 10.9 0.0 2.8 3 0 0 3 3 3 2 Tenuivirus major non-capsid protein CH PF00307.26 ESL09312.1 - 0.072 13.1 0.7 0.65 10.0 0.1 2.7 3 0 0 3 3 3 0 Calponin homology (CH) domain DUF3808 PF10300.4 ESL09313.1 - 3.2e-23 82.0 3.6 3.8e-23 81.7 1.0 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF3808) TPR_12 PF13424.1 ESL09313.1 - 1.1e-06 28.4 11.7 0.02 14.8 0.0 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09313.1 - 5.8e-05 23.6 8.0 2.8 8.7 0.0 5.4 5 1 2 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESL09313.1 - 0.0012 17.9 0.8 0.0042 16.1 0.5 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat DUF2225 PF09986.4 ESL09313.1 - 0.0013 18.2 0.7 0.0072 15.8 0.1 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_14 PF13428.1 ESL09313.1 - 0.0037 17.7 2.3 30 5.6 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL09313.1 - 0.097 12.6 0.3 0.097 12.6 0.2 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL09313.1 - 0.25 11.0 14.5 0.24 11.0 0.6 4.6 5 0 0 5 5 5 0 TPR repeat TPR_19 PF14559.1 ESL09313.1 - 0.58 10.5 0.0 0.58 10.5 0.0 4.8 4 2 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09313.1 - 4.2 7.1 7.1 32 4.3 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESL09313.1 - 4.5 7.9 5.9 1.2e+02 3.5 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat PSP1 PF04468.7 ESL09314.1 - 9.2e-33 112.0 0.7 1.5e-32 111.3 0.5 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Jnk-SapK_ap_N PF09744.4 ESL09315.1 - 9.2 6.2 34.0 1.3 9.0 4.2 3.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Acyltransferase PF01553.16 ESL09316.1 - 2.7e-19 68.9 0.0 6.6e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase zf-DHHC PF01529.15 ESL09317.1 - 4.8e-12 45.6 8.3 4.8e-12 45.6 5.7 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase zf-CCCH PF00642.19 ESL09318.1 - 4e-05 23.1 13.3 0.00087 18.9 2.2 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_L35Ae PF01247.13 ESL09319.1 - 2.7e-36 123.2 1.8 4.1e-36 122.6 1.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 ESL09319.1 - 7.6e-05 22.5 1.0 0.16 11.8 0.0 2.4 2 1 0 2 2 2 2 RimM N-terminal domain Not3 PF04065.10 ESL09321.1 - 6e-12 45.3 0.5 1.1e-11 44.5 0.3 1.4 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Mucin PF01456.12 ESL09321.1 - 0.063 13.0 10.8 0.091 12.5 7.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Med3 PF11593.3 ESL09321.1 - 0.21 10.7 3.9 0.23 10.6 2.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Aldedh PF00171.17 ESL09322.1 - 2.3e-131 438.3 0.9 2.7e-131 438.1 0.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-C2H2_4 PF13894.1 ESL09323.1 - 1.1e-05 25.3 17.6 0.12 12.7 0.0 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.21 ESL09323.1 - 5.9e-05 23.1 21.5 0.094 13.1 0.0 6.1 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 ESL09323.1 - 0.0013 18.8 9.7 0.2 11.7 0.1 4.6 4 3 1 5 5 5 1 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 ESL09323.1 - 0.13 12.5 9.2 12 6.4 0.1 5.2 5 0 0 5 5 5 0 Zinc-finger double domain zf-H2C2_5 PF13909.1 ESL09323.1 - 0.25 11.6 0.0 0.25 11.6 0.0 5.9 6 1 0 6 6 6 0 C2H2-type zinc-finger domain zf-BED PF02892.10 ESL09323.1 - 0.55 10.0 7.0 18 5.1 1.2 3.9 3 1 1 4 4 4 0 BED zinc finger zf-met2 PF12907.2 ESL09323.1 - 8 6.5 9.8 17 5.4 0.1 4.1 4 0 0 4 4 4 0 Zinc-binding WD40 PF00400.27 ESL09324.1 - 0.00014 21.6 2.2 0.43 10.5 0.1 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat FA_desaturase PF00487.19 ESL09325.1 - 2.3e-13 50.2 23.8 2.3e-13 50.2 16.5 1.9 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.23 ESL09325.1 - 4.7e-07 29.5 0.3 5.4e-06 26.1 0.0 2.7 2 1 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain ubiquitin PF00240.18 ESL09327.1 - 3.1e-18 64.9 0.1 3.5e-18 64.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESL09327.1 - 5.9e-11 41.8 0.2 6.7e-11 41.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESL09327.1 - 3.1e-05 24.1 0.1 0.0001 22.4 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESL09327.1 - 0.00051 19.9 0.2 0.0022 17.8 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ESL09327.1 - 0.054 13.6 0.0 0.061 13.5 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF2604 PF10790.4 ESL09327.1 - 0.079 13.1 0.0 0.1 12.7 0.0 1.4 1 1 0 1 1 1 0 Protein of Unknown function (DUF2604) Lactamase_B_5 PF14597.1 ESL09327.1 - 0.15 11.4 0.1 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Pkinase PF00069.20 ESL09328.1 - 6.8e-69 231.8 0.0 8.6e-69 231.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09328.1 - 1.9e-34 118.9 0.0 2.7e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESL09328.1 - 7.8e-11 41.7 10.1 7.8e-11 41.7 7.0 2.2 2 0 0 2 2 2 1 FYVE zinc finger Kinase-like PF14531.1 ESL09328.1 - 7.6e-05 21.8 0.0 0.00014 20.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH PF00169.24 ESL09328.1 - 0.00013 22.1 0.0 0.00023 21.3 0.0 1.5 1 0 0 1 1 1 1 PH domain Kdo PF06293.9 ESL09328.1 - 0.00067 18.7 0.0 0.0016 17.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DZR PF12773.2 ESL09328.1 - 0.31 10.9 15.1 43 4.0 10.9 2.9 1 1 1 2 2 2 0 Double zinc ribbon Lysine_decarbox PF03641.9 ESL09329.1 - 8.7e-29 100.0 0.4 1.3e-28 99.4 0.3 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase ABM PF03992.11 ESL09329.1 - 4e-10 39.5 0.1 9.1e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF866 PF05907.8 ESL09331.1 - 4.4e-21 75.0 0.0 5.3e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) DND1_DSRM PF14709.1 ESL09332.1 - 0.00024 21.3 0.1 0.0015 18.7 0.0 2.4 3 0 0 3 3 3 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.20 ESL09332.1 - 0.0043 17.5 0.0 0.01 16.3 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif TPR_16 PF13432.1 ESL09333.1 - 2.5e-05 24.8 0.3 0.00019 21.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL09333.1 - 0.00021 20.8 0.2 0.00055 19.5 0.2 1.6 1 0 0 1 1 1 1 TPR repeat TPR_14 PF13428.1 ESL09333.1 - 0.00026 21.3 1.3 0.0023 18.3 0.4 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Ank_5 PF13857.1 ESL09333.1 - 0.0035 17.5 0.1 0.013 15.7 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) TPR_2 PF07719.12 ESL09333.1 - 0.099 12.6 1.5 0.27 11.2 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Kinesin PF00225.18 ESL09334.1 - 7.5e-84 281.2 0.0 9.7e-84 280.9 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Rab5-bind PF09311.6 ESL09334.1 - 0.0012 18.7 0.1 0.0023 17.8 0.1 1.4 1 0 0 1 1 1 1 Rabaptin-like protein Ribosomal_L11_N PF03946.9 ESL09335.1 - 1.5e-13 49.9 0.0 2.4e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 ESL09335.1 - 1.4e-05 25.0 0.0 3.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain LicD PF04991.8 ESL09336.1 - 6.9e-16 58.9 0.1 2.2e-09 37.7 0.0 2.1 1 1 1 2 2 2 2 LicD family AA_permease_C PF13906.1 ESL09336.1 - 0.6 10.0 3.0 1.2 9.1 2.1 1.4 1 0 0 1 1 1 0 C-terminus of AA_permease DnaJ PF00226.26 ESL09338.1 - 1.7e-17 62.8 0.3 7.9e-17 60.7 0.0 2.4 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.1 ESL09338.1 - 2.6e-06 27.4 4.7 0.031 14.3 0.3 3.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain DUF2937 PF11157.3 ESL09338.1 - 0.081 12.2 0.0 0.27 10.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) SpoVR PF04293.8 ESL09338.1 - 2.3 6.5 13.6 1.3 7.3 7.2 2.0 2 0 0 2 2 2 0 SpoVR like protein GTP_EFTU PF00009.22 ESL09339.1 - 6.6e-57 191.9 0.0 1.2e-56 191.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL09339.1 - 6.7e-20 71.1 0.4 1.8e-18 66.5 0.0 2.8 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL09339.1 - 1.4e-06 28.3 0.6 5.2e-06 26.4 0.4 2.1 1 1 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESL09339.1 - 0.00011 22.1 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 ESL09339.1 - 0.00036 20.1 0.5 0.00087 18.8 0.3 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Miro PF08477.8 ESL09339.1 - 0.053 14.0 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 ESL09339.1 - 0.07 12.6 0.1 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain NAP PF00956.13 ESL09342.1 - 9.6e-61 204.9 0.0 1.6e-60 204.2 0.0 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF3452 PF11934.3 ESL09342.1 - 0.014 14.7 1.6 0.038 13.3 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) Clusterin PF01093.12 ESL09342.1 - 0.09 11.5 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Clusterin DUF4576 PF15144.1 ESL09342.1 - 0.1 12.2 0.7 0.26 10.9 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4576) Nucleoplasmin PF03066.10 ESL09342.1 - 0.2 11.1 6.7 2.9 7.3 0.1 2.4 2 0 0 2 2 2 0 Nucleoplasmin YL1 PF05764.8 ESL09342.1 - 6.5 6.2 10.5 0.36 10.4 3.3 1.7 2 0 0 2 2 2 0 YL1 nuclear protein COX15-CtaA PF02628.10 ESL09343.1 - 1e-88 297.1 13.5 1.4e-88 296.7 9.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein TPR_12 PF13424.1 ESL09344.1 - 7.4e-62 205.2 50.4 1.8e-13 50.2 0.7 8.2 7 1 1 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.1 ESL09344.1 - 4.8e-35 118.4 41.5 1.1e-05 25.1 0.1 11.6 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_11 PF13414.1 ESL09344.1 - 2.2e-24 84.8 47.3 1.1e-06 28.1 0.6 7.7 6 2 3 9 9 9 8 TPR repeat TPR_2 PF07719.12 ESL09344.1 - 8.2e-19 65.9 49.9 0.057 13.3 0.0 12.3 12 1 0 12 12 12 8 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09344.1 - 7.1e-17 60.2 43.8 0.12 12.0 0.0 12.6 14 0 0 14 14 14 9 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09344.1 - 8.8e-15 54.9 41.3 0.0014 19.2 0.4 9.2 5 3 4 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09344.1 - 3.6e-14 51.9 39.2 0.19 12.4 0.1 11.5 9 3 3 12 12 12 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09344.1 - 1.6e-13 49.3 29.8 0.011 15.4 1.0 10.2 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESL09344.1 - 1.1e-12 46.6 37.8 0.023 14.4 0.0 11.8 13 0 0 13 13 13 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESL09344.1 - 4.7e-05 23.6 39.4 0.11 12.8 1.0 8.1 5 2 5 10 10 10 4 Tetratricopeptide repeat Apc5 PF12862.2 ESL09344.1 - 0.24 11.2 21.4 1.3 8.9 0.6 6.4 3 2 1 4 4 4 0 Anaphase-promoting complex subunit 5 TPR_17 PF13431.1 ESL09344.1 - 3.2 8.1 19.4 43 4.6 0.0 8.3 9 1 0 9 9 9 0 Tetratricopeptide repeat 14-3-3 PF00244.15 ESL09345.1 - 7.3e-97 323.0 3.9 8.4e-97 322.8 2.7 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 ESL09345.1 - 0.0025 17.6 1.0 0.041 13.8 0.3 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL09345.1 - 0.024 14.2 0.2 0.076 12.6 0.1 1.9 1 1 0 1 1 1 0 TPR repeat TPR_2 PF07719.12 ESL09345.1 - 0.27 11.2 1.9 6.4 6.9 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat F-box PF00646.28 ESL09347.1 - 0.0045 16.6 0.0 0.0099 15.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESL09347.1 - 0.0087 15.7 0.1 0.018 14.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like Reo_sigmaC PF04582.7 ESL09347.1 - 0.076 12.1 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Uteroglobin PF01099.12 ESL09347.1 - 0.11 12.2 1.3 0.18 11.6 0.1 1.9 2 0 0 2 2 2 0 Uteroglobin family Tropomyosin_1 PF12718.2 ESL09347.1 - 0.16 11.8 6.2 0.082 12.7 0.8 2.3 2 0 0 2 2 2 0 Tropomyosin like Cast PF10174.4 ESL09347.1 - 0.2 9.6 11.6 0.46 8.4 8.0 1.5 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone IncA PF04156.9 ESL09347.1 - 0.21 11.1 9.5 0.046 13.3 2.1 2.2 2 0 0 2 2 2 0 IncA protein Fib_alpha PF08702.5 ESL09347.1 - 0.23 11.5 3.7 0.54 10.3 2.5 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SlyX PF04102.7 ESL09347.1 - 0.39 11.1 6.6 0.48 10.8 1.5 2.7 2 0 0 2 2 2 0 SlyX ADIP PF11559.3 ESL09347.1 - 0.39 10.6 12.0 4.1 7.2 4.0 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding VPS11_C PF12451.3 ESL09347.1 - 0.4 10.5 1.7 0.93 9.4 0.4 2.3 3 0 0 3 3 2 0 Vacuolar protein sorting protein 11 C terminal Spc24 PF08286.6 ESL09347.1 - 0.4 10.3 2.8 0.54 9.9 0.6 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 GrpE PF01025.14 ESL09347.1 - 0.45 10.0 5.2 1.2 8.6 0.7 2.2 2 0 0 2 2 2 0 GrpE Prefoldin_2 PF01920.15 ESL09347.1 - 0.75 9.5 9.8 6.7 6.5 0.1 2.4 2 0 0 2 2 2 0 Prefoldin subunit TBPIP PF07106.8 ESL09347.1 - 1.2 8.6 4.8 0.25 10.8 0.4 1.9 3 0 0 3 3 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FlaC_arch PF05377.6 ESL09347.1 - 1.2 9.0 4.6 25 4.8 0.4 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.3 ESL09347.1 - 1.3 8.8 10.7 1.4 8.8 4.9 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.6 ESL09347.1 - 2.3 6.7 7.6 0.55 8.8 2.7 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Ax_dynein_light PF10211.4 ESL09347.1 - 3.5 7.4 9.6 1.1 9.0 3.1 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain APG6 PF04111.7 ESL09347.1 - 3.6 6.5 7.8 7.1 5.5 5.4 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 SseC PF04888.7 ESL09347.1 - 4.3 6.5 6.1 7.5 5.7 4.2 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF3450 PF11932.3 ESL09347.1 - 8.1 5.6 11.3 1.3 8.2 3.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Ring_hydroxyl_A PF00848.14 ESL09348.1 - 0.43 10.1 2.8 0.5 9.9 0.2 2.4 2 0 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) GAS PF13851.1 ESL09348.1 - 0.89 8.7 38.2 1.6 7.8 0.3 5.6 4 1 0 5 5 5 0 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 ESL09348.1 - 6.3 5.8 18.5 0.58 9.2 1.1 3.9 2 1 2 4 4 4 0 Reovirus sigma C capsid protein Sec5 PF15469.1 ESL09349.1 - 2.4e-06 27.3 0.0 4.9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 Pribosyltran_N PF13793.1 ESL09350.1 - 4.5e-41 139.2 0.2 1.1e-39 134.7 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESL09350.1 - 1.4e-29 103.1 2.3 1.8e-28 99.5 0.5 2.2 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ESL09350.1 - 5.3e-13 48.7 0.1 1.1e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESL09350.1 - 0.00026 20.2 0.0 0.00057 19.1 0.0 1.6 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Peptidase_M17 PF00883.16 ESL09351.1 - 4.8e-86 288.4 0.0 7.6e-86 287.7 0.0 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Spc97_Spc98 PF04130.8 ESL09352.1 - 2.1e-19 69.2 0.0 5.1e-19 68.0 0.0 1.6 1 1 0 1 1 1 1 Spc97 / Spc98 family Pro_isomerase PF00160.16 ESL09353.1 - 8.9e-44 149.4 0.0 1.1e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M76 PF09768.4 ESL09357.1 - 1.9e-57 193.4 0.1 2.3e-57 193.2 0.1 1.0 1 0 0 1 1 1 1 Peptidase M76 family Tox-MPTase3 PF15639.1 ESL09357.1 - 0.025 14.3 0.0 0.042 13.5 0.0 1.4 1 0 0 1 1 1 0 Metallopeptidase toxin 3 Peptidase_M91 PF14891.1 ESL09357.1 - 0.028 14.4 0.1 0.12 12.3 0.1 1.9 1 1 0 1 1 1 0 Effector protein Glyoxal_oxid_N PF07250.6 ESL09357.1 - 0.036 13.1 0.1 0.051 12.6 0.0 1.2 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus HTH_30 PF13556.1 ESL09357.1 - 0.049 13.2 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Paf67 PF10255.4 ESL09358.1 - 0.077 11.8 0.1 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 Fibrillarin PF01269.12 ESL09359.1 - 2.6e-103 343.8 0.0 3e-103 343.6 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 ESL09359.1 - 2.3e-07 30.6 0.0 3.1e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit DUF4090 PF13319.1 ESL09360.1 - 0.055 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) Lge1 PF11488.3 ESL09360.1 - 0.19 11.9 0.3 0.19 11.9 0.2 2.0 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 Toxin_55 PF15606.1 ESL09360.1 - 0.2 11.6 2.6 0.87 9.6 0.4 2.4 1 1 1 2 2 2 0 Putative toxin 55 Prp19 PF08606.6 ESL09360.1 - 1 9.1 5.1 15 5.4 0.0 3.0 3 0 0 3 3 3 0 Prp19/Pso4-like DNA_pol_viral_N PF00242.12 ESL09360.1 - 4.2 6.3 6.9 3.2 6.6 0.2 2.2 1 1 1 2 2 2 0 DNA polymerase (viral) N-terminal domain APG6 PF04111.7 ESL09360.1 - 6.6 5.6 8.0 8.2 5.3 5.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-MIZ PF02891.15 ESL09361.1 - 7.5e-17 60.5 6.7 1.4e-16 59.6 4.7 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PWWP PF00855.12 ESL09361.1 - 4e-05 23.7 0.6 7.7e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 PWWP domain zf-Nse PF11789.3 ESL09361.1 - 0.00015 21.1 1.2 0.00029 20.2 0.8 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SKG6 PF08693.5 ESL09361.1 - 0.037 13.3 0.6 0.12 11.6 0.4 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain OTU PF02338.14 ESL09362.1 - 1.3e-16 61.2 0.1 3e-16 60.0 0.1 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ESL09362.1 - 0.00022 20.6 0.0 0.029 13.7 0.0 2.4 1 1 1 2 2 2 2 Peptidase C65 Otubain zf-RanBP PF00641.13 ESL09362.1 - 0.0027 16.7 1.8 0.0027 16.7 1.2 4.9 5 0 0 5 5 5 3 Zn-finger in Ran binding protein and others zf-tcix PF14952.1 ESL09362.1 - 0.037 13.3 0.1 0.037 13.3 0.1 3.8 3 1 1 4 4 4 0 Putative treble-clef, zinc-finger, Zn-binding DZR PF12773.2 ESL09362.1 - 5.6 6.8 40.3 0.74 9.6 7.8 4.1 4 1 0 4 4 4 0 Double zinc ribbon IFT43 PF15305.1 ESL09363.1 - 9e-09 35.4 1.8 9e-09 35.4 1.2 3.6 2 2 2 4 4 4 1 Intraflagellar transport protein 43 Cation_ATPase_C PF00689.16 ESL09365.1 - 0.85 9.1 14.2 1.1 8.7 9.8 1.1 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF872 PF05915.7 ESL09365.1 - 1.4 8.7 5.0 0.39 10.5 0.2 2.2 1 1 2 3 3 3 0 Eukaryotic protein of unknown function (DUF872) TrbC PF04956.8 ESL09365.1 - 9.1 6.3 10.2 3.8 7.5 2.9 2.3 1 1 1 2 2 2 0 TrbC/VIRB2 family Exo_endo_phos PF03372.18 ESL09366.1 - 5.3e-19 69.1 0.0 6.3e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ASRT PF07100.6 ESL09366.1 - 0.047 13.4 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer FMN_dh PF01070.13 ESL09367.1 - 2.9e-06 26.3 0.0 3.4e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase APG6 PF04111.7 ESL09368.1 - 0.53 9.2 12.9 0.7 8.8 9.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 FBPase PF00316.15 ESL09369.1 - 8.9e-68 228.4 0.0 1.1e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 ESL09369.1 - 0.0062 15.8 0.0 0.0096 15.2 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family PUF PF00806.14 ESL09370.1 - 1.1e-15 56.0 0.0 0.00097 18.4 0.0 5.6 5 1 1 6 6 6 4 Pumilio-family RNA binding repeat DUF1414 PF07208.6 ESL09370.1 - 0.0038 16.8 0.1 0.029 14.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1414) AMH_N PF04709.7 ESL09370.1 - 0.011 14.6 0.8 0.24 10.3 0.0 2.3 2 0 0 2 2 2 0 Anti-Mullerian hormone, N terminal region Sec23_trunk PF04811.10 ESL09371.1 - 0.13 11.6 0.0 0.52 9.6 0.0 1.9 2 0 0 2 2 2 0 Sec23/Sec24 trunk domain Cytochrom_C PF00034.16 ESL09372.1 - 2.1e-10 41.2 0.0 2.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 ESL09372.1 - 0.00018 21.6 2.3 0.00088 19.3 1.6 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Oxidored_molyb PF00174.14 ESL09373.1 - 0.004 16.5 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain LRR_4 PF12799.2 ESL09375.1 - 3.4e-08 32.9 2.6 0.00013 21.5 0.1 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL09375.1 - 0.05 13.3 0.1 0.12 12.1 0.1 1.7 1 0 0 1 1 1 0 Leucine rich repeat LRR_1 PF00560.28 ESL09375.1 - 0.071 13.1 0.1 24 5.4 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_3 PF07725.7 ESL09375.1 - 0.096 12.4 0.4 0.27 11.0 0.3 1.8 1 0 0 1 1 1 0 Leucine Rich Repeat LRR_9 PF14580.1 ESL09375.1 - 0.13 11.8 0.0 1.7 8.1 0.0 2.0 1 1 1 2 2 2 0 Leucine-rich repeat cNMP_binding PF00027.24 ESL09376.1 - 4e-14 52.2 0.0 1.1e-06 28.3 0.0 3.8 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain TEX13 PF15186.1 ESL09376.1 - 0.15 11.6 0.6 0.3 10.6 0.4 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family GTP_EFTU PF00009.22 ESL09377.1 - 5.9e-55 185.6 0.0 1e-54 184.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL09377.1 - 5.4e-35 119.5 0.1 3.2e-34 117.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL09377.1 - 7.5e-18 64.4 0.6 7.5e-18 64.4 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 ESL09377.1 - 1.1e-05 24.9 0.1 4.3e-05 23.0 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 ESL09377.1 - 2.1e-05 24.4 0.0 0.00052 19.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL09377.1 - 0.0023 18.3 0.2 0.068 13.6 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL09377.1 - 0.024 13.7 0.0 0.055 12.6 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Semialdhyde_dhC PF02774.13 ESL09377.1 - 0.024 14.4 0.1 0.33 10.8 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Dynamin_N PF00350.18 ESL09377.1 - 0.11 12.3 0.0 16 5.2 0.0 2.5 2 0 0 2 2 2 0 Dynamin family LRR_6 PF13516.1 ESL09378.1 - 1.2e-07 31.0 14.5 0.15 12.2 0.3 9.1 8 1 1 9 9 9 2 Leucine Rich repeat LRR_4 PF12799.2 ESL09378.1 - 5.7e-07 29.0 1.7 0.14 11.8 0.0 6.4 6 1 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL09378.1 - 0.0081 16.0 13.4 55 4.3 0.0 9.3 11 0 0 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.1 ESL09378.1 - 0.16 11.7 10.0 12 5.7 0.0 5.7 5 2 1 6 6 6 0 Leucine rich repeat LRR_7 PF13504.1 ESL09378.1 - 0.19 12.0 21.2 34 5.2 0.3 9.3 11 0 0 11 11 11 0 Leucine rich repeat MBOAT PF03062.14 ESL09379.1 - 2.7e-36 125.3 25.5 2.7e-36 125.3 17.7 2.0 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DSPc PF00782.15 ESL09380.1 - 6.4e-14 51.6 0.1 1.3e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL09380.1 - 0.0017 17.7 0.0 0.0023 17.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase UPF0118 PF01594.11 ESL09381.1 - 1.3e-05 24.3 17.2 0.00014 20.9 1.6 3.4 3 0 0 3 3 3 2 Domain of unknown function DUF20 NUC173 PF08161.7 ESL09382.1 - 1.1e-12 47.6 0.0 4.2e-12 45.8 0.0 2.1 1 1 0 1 1 1 1 NUC173 domain VPS28 PF03997.7 ESL09383.1 - 1.9e-43 148.2 0.5 2.2e-43 148.0 0.3 1.0 1 0 0 1 1 1 1 VPS28 protein DUF445 PF04286.7 ESL09383.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) SHOCT PF09851.4 ESL09383.1 - 0.18 11.3 2.7 0.39 10.2 0.5 2.4 2 0 0 2 2 2 0 Short C-terminal domain CHAP PF05257.11 ESL09384.1 - 2.4e-12 46.6 0.0 4.3e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 CHAP domain adh_short PF00106.20 ESL09385.1 - 4.5e-22 78.7 2.1 8.9e-22 77.7 0.3 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ESL09385.1 - 1.8e-07 31.0 0.2 3.8e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESL09385.1 - 4.4e-06 26.6 0.5 5.8e-06 26.2 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESL09385.1 - 7.7e-05 22.7 0.3 0.00015 21.8 0.1 1.5 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 ESL09385.1 - 0.0038 16.2 1.5 0.004 16.1 0.0 1.8 3 0 0 3 3 3 1 Saccharopine dehydrogenase NAD_binding_2 PF03446.10 ESL09385.1 - 0.0051 16.6 0.2 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Adap_comp_sub PF00928.16 ESL09386.1 - 1.2e-09 37.7 0.0 1.6e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Herpes_capsid PF06112.6 ESL09386.1 - 0.52 10.3 9.8 0.19 11.7 2.1 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Snf7 PF03357.16 ESL09388.1 - 3.9e-26 91.4 4.9 4.8e-26 91.1 3.4 1.1 1 0 0 1 1 1 1 Snf7 DUF3356 PF11836.3 ESL09388.1 - 0.19 11.5 2.9 0.24 11.2 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3356) Snf7 PF03357.16 ESL09389.1 - 3.5e-32 111.1 23.3 3.5e-32 111.1 16.1 1.6 1 1 1 2 2 2 1 Snf7 PSD4 PF07631.6 ESL09389.1 - 0.37 11.1 3.3 0.42 10.9 1.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) Carn_acyltransf PF00755.15 ESL09390.1 - 4.1e-125 418.1 0.0 4.9e-125 417.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Ribosomal_S27e PF01667.12 ESL09391.1 - 5.5e-23 80.2 3.7 7e-23 79.9 2.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 ESL09391.1 - 0.00051 19.8 1.9 0.00061 19.6 1.3 1.2 1 0 0 1 1 1 1 IBR domain Elf1 PF05129.8 ESL09391.1 - 0.068 12.8 1.5 0.1 12.3 1.0 1.2 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Zn_Tnp_IS1595 PF12760.2 ESL09391.1 - 0.14 12.0 0.9 0.2 11.5 0.6 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain FYVE_2 PF02318.11 ESL09391.1 - 0.14 12.0 0.9 0.16 11.8 0.6 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger Zn_Tnp_IS1 PF03811.8 ESL09391.1 - 0.15 11.5 4.3 0.48 9.9 3.0 1.9 1 1 0 1 1 1 0 InsA N-terminal domain zinc_ribbon_4 PF13717.1 ESL09391.1 - 0.17 11.5 3.1 2.6 7.8 2.1 2.4 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESL09391.1 - 0.26 10.8 3.1 3.3 7.3 2.2 2.3 1 1 0 1 1 1 0 zinc-ribbon domain Yippee-Mis18 PF03226.9 ESL09391.1 - 0.42 10.6 3.0 5.7 7.0 0.0 2.1 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly OrfB_Zn_ribbon PF07282.6 ESL09391.1 - 0.52 9.9 3.6 0.36 10.5 1.5 1.5 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf-LSD1 PF06943.7 ESL09391.1 - 4.3 7.0 6.9 15 5.2 0.0 3.1 3 0 0 3 3 3 0 LSD1 zinc finger PPO1_DWL PF12142.3 ESL09394.1 - 0.034 13.6 0.3 0.78 9.3 0.0 2.4 2 0 0 2 2 2 0 Polyphenol oxidase middle domain Flg_hook PF02120.11 ESL09394.1 - 0.096 12.3 0.0 0.096 12.3 0.0 2.0 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK cNMP_binding PF00027.24 ESL09395.1 - 3.9e-08 32.9 0.2 8.7e-06 25.4 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DSPc PF00782.15 ESL09397.1 - 4.3e-11 42.5 0.0 6.1e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESL09397.1 - 0.00034 20.6 0.0 0.00047 20.2 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.7 ESL09397.1 - 0.0024 17.3 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.1 ESL09397.1 - 0.0035 17.6 0.0 0.0046 17.2 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESL09397.1 - 0.029 13.7 0.1 0.04 13.2 0.1 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase TPR_12 PF13424.1 ESL09401.1 - 7.1e-07 29.0 4.1 1.8e-05 24.6 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat IQ PF00612.22 ESL09401.1 - 9.2e-06 24.8 45.6 0.0054 16.2 1.2 7.6 8 0 0 8 8 8 5 IQ calmodulin-binding motif TPR_10 PF13374.1 ESL09401.1 - 0.0002 21.1 1.3 1.8 8.6 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TMF_DNA_bd PF12329.3 ESL09402.1 - 0.5 10.2 14.8 4.6 7.1 0.1 4.2 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding SNARE PF05739.14 ESL09403.1 - 0.00033 20.2 5.6 0.00033 20.2 3.9 2.6 3 0 0 3 3 3 1 SNARE domain V-SNARE_C PF12352.3 ESL09403.1 - 0.00049 20.0 3.4 0.15 12.1 1.0 2.7 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Syntaxin-6_N PF09177.6 ESL09403.1 - 0.00088 19.6 0.3 0.00088 19.6 0.2 2.6 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.7 ESL09403.1 - 0.035 13.9 6.9 1.1 9.0 2.4 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FNIP_C PF14638.1 ESL09403.1 - 0.16 11.2 1.3 0.3 10.3 0.3 1.8 2 0 0 2 2 2 0 Folliculin-interacting protein C-terminus Herpes_US9 PF06072.6 ESL09403.1 - 0.18 11.6 0.7 0.38 10.6 0.5 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Zwint PF15556.1 ESL09403.1 - 2.1 7.5 11.8 5.4 6.1 4.1 2.2 2 0 0 2 2 2 0 ZW10 interactor DUF1664 PF07889.7 ESL09403.1 - 2.1 8.1 9.8 0.69 9.7 1.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Sec2p PF06428.6 ESL09403.1 - 2.6 7.9 13.7 0.97 9.3 0.3 3.2 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p TBCA PF02970.11 ESL09403.1 - 3.1 7.9 8.4 0.82 9.7 1.8 2.6 2 2 0 2 2 2 0 Tubulin binding cofactor A Latarcin PF10279.4 ESL09403.1 - 3.3 7.9 11.2 37 4.6 0.2 3.1 2 1 0 2 2 2 0 Latarcin precursor Spc7 PF08317.6 ESL09403.1 - 8 5.0 10.0 1.6 7.2 0.2 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein zf-MIZ PF02891.15 ESL09405.1 - 5.9e-05 22.4 0.5 0.00051 19.4 0.0 2.4 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger WD40 PF00400.27 ESL09406.1 - 4.7e-15 54.8 10.0 0.0001 22.0 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat PQQ_2 PF13360.1 ESL09406.1 - 0.0042 16.5 0.1 0.0082 15.6 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain Nup160 PF11715.3 ESL09406.1 - 0.023 12.8 0.0 0.15 10.1 0.0 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF3472 PF11958.3 ESL09407.1 - 0.17 12.1 0.2 0.4 11.0 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3472) MAD PF05557.8 ESL09408.1 - 0.00069 17.8 24.9 0.001 17.3 17.2 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF972 PF06156.8 ESL09408.1 - 0.002 18.4 9.9 0.002 18.4 6.9 3.7 1 1 2 3 3 3 1 Protein of unknown function (DUF972) IncA PF04156.9 ESL09408.1 - 0.0026 17.4 33.0 0.28 10.7 16.4 2.4 1 1 1 2 2 2 1 IncA protein TBPIP PF07106.8 ESL09408.1 - 0.0088 15.6 10.8 0.0088 15.6 7.5 2.4 1 1 0 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Myosin_tail_1 PF01576.14 ESL09408.1 - 0.0089 13.8 33.8 0.012 13.3 23.5 1.2 1 0 0 1 1 1 1 Myosin tail EzrA PF06160.7 ESL09408.1 - 0.017 13.3 23.8 0.041 12.0 9.2 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA GAS PF13851.1 ESL09408.1 - 0.04 13.1 30.4 0.13 11.4 8.5 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.7 ESL09408.1 - 0.077 12.7 28.0 0.25 11.0 5.8 2.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Amidase_3 PF01520.13 ESL09408.1 - 0.08 12.7 0.4 0.14 11.9 0.3 1.4 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase DASH_Dam1 PF08653.5 ESL09408.1 - 0.1 12.3 4.1 0.22 11.2 1.2 2.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 TcdB_N PF12918.2 ESL09408.1 - 0.11 12.5 1.8 0.54 10.3 0.5 2.5 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Fez1 PF06818.10 ESL09408.1 - 0.13 12.3 29.4 0.039 13.9 11.3 2.4 1 1 1 2 2 2 0 Fez1 Filament PF00038.16 ESL09408.1 - 0.13 11.7 33.2 0.066 12.6 5.5 2.7 1 1 1 2 2 2 0 Intermediate filament protein Atg14 PF10186.4 ESL09408.1 - 0.25 10.2 28.5 0.29 10.0 5.9 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 ESL09408.1 - 0.27 9.6 20.7 0.079 11.3 6.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.7 ESL09408.1 - 0.48 9.5 2.5 4.6 6.3 0.4 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Fib_alpha PF08702.5 ESL09408.1 - 0.6 10.2 14.0 1.7 8.7 1.7 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family MCPsignal PF00015.16 ESL09408.1 - 0.78 9.2 6.6 0.75 9.2 1.1 2.2 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain MRP-S27 PF10037.4 ESL09408.1 - 0.81 8.5 17.5 1.1 8.1 12.1 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 NYD-SP28_assoc PF14775.1 ESL09408.1 - 0.88 9.3 6.5 1.1 8.9 2.8 2.6 1 1 1 2 2 2 0 Sperm tail C-terminal domain Syntaxin PF00804.20 ESL09408.1 - 1 9.5 20.0 2.1 8.5 2.0 2.7 1 1 2 3 3 3 0 Syntaxin Laminin_II PF06009.7 ESL09408.1 - 1.1 9.0 14.0 2 8.1 3.6 2.8 1 1 1 2 2 2 0 Laminin Domain II CENP-F_leu_zip PF10473.4 ESL09408.1 - 1.3 8.8 37.3 0.89 9.4 5.6 3.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WEMBL PF05701.6 ESL09408.1 - 1.6 7.0 32.0 0.017 13.6 6.2 2.2 1 1 1 2 2 2 0 Weak chloroplast movement under blue light DUF3251 PF11622.3 ESL09408.1 - 1.9 7.8 5.0 0.59 9.5 0.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3251) Seryl_tRNA_N PF02403.17 ESL09408.1 - 2 8.4 19.6 0.66 10.0 4.0 3.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Nup54 PF13874.1 ESL09408.1 - 2.3 7.9 25.9 0.55 9.8 7.6 3.3 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 Spc7 PF08317.6 ESL09408.1 - 2.4 6.7 25.3 3.9 6.0 4.6 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF2205 PF10224.4 ESL09408.1 - 2.9 7.5 18.3 0.31 10.6 4.9 3.5 1 1 3 4 4 4 0 Predicted coiled-coil protein (DUF2205) Taxilin PF09728.4 ESL09408.1 - 3.5 6.6 34.8 8.6 5.3 13.7 2.7 1 1 2 3 3 3 0 Myosin-like coiled-coil protein DUF1451 PF07295.6 ESL09408.1 - 4.5 7.0 20.8 0.019 14.7 5.2 2.7 1 1 2 3 3 2 0 Protein of unknown function (DUF1451) APG6 PF04111.7 ESL09408.1 - 6.1 5.7 33.5 6.5 5.7 14.4 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF3584 PF12128.3 ESL09408.1 - 6.7 3.9 29.9 25 2.0 20.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Prominin PF05478.6 ESL09408.1 - 8.8 3.7 11.7 8.2 3.8 3.9 1.5 1 1 1 2 2 2 0 Prominin CorA PF01544.13 ESL09408.1 - 9.3 5.1 20.1 9 5.2 0.5 2.2 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Gly_kinase PF02595.10 ESL09409.1 - 4.6e-50 170.3 3.1 6.5e-41 140.2 1.5 3.2 2 1 0 2 2 2 2 Glycerate kinase family Nop14 PF04147.7 ESL09411.1 - 1.4e-40 139.1 14.1 1.2e-23 83.0 0.0 2.8 1 1 0 2 2 2 2 Nop14-like family DUF3232 PF11554.3 ESL09414.1 - 0.015 15.1 0.8 0.026 14.4 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3232) Fmp27_WPPW PF10359.4 ESL09414.1 - 0.069 11.5 3.7 0.11 10.9 2.6 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Phage_GPO PF05929.6 ESL09414.1 - 0.14 11.3 1.0 0.23 10.6 0.7 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase LXG PF04740.7 ESL09414.1 - 0.15 11.8 2.2 6 6.6 0.6 2.4 2 1 0 2 2 2 0 LXG domain of WXG superfamily Rootletin PF15035.1 ESL09414.1 - 0.18 11.7 11.0 0.31 10.9 5.1 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion FlgN PF05130.7 ESL09414.1 - 1.8 8.7 9.1 19 5.4 0.0 2.3 2 0 0 2 2 2 0 FlgN protein DUF2730 PF10805.3 ESL09414.1 - 5.6 6.7 6.4 0.67 9.7 1.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Tropomyosin PF00261.15 ESL09414.1 - 6.3 5.8 12.1 0.65 9.0 2.4 2.4 2 1 1 3 3 3 0 Tropomyosin TPR_11 PF13414.1 ESL09416.1 - 0.00013 21.5 13.8 0.0002 20.9 3.6 2.5 2 1 0 2 2 2 2 TPR repeat MIT PF04212.13 ESL09416.1 - 0.00081 19.2 2.3 0.0035 17.2 0.5 2.4 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 ESL09416.1 - 1.4 8.6 8.4 3.4 7.4 1.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL09416.1 - 3.3 7.8 15.5 0.36 10.8 1.4 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL09416.1 - 7.8 7.2 7.5 1.7 9.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-RING_2 PF13639.1 ESL09417.1 - 9.5e-16 57.3 4.9 1.4e-15 56.8 3.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESL09417.1 - 3.9e-12 46.1 0.7 6.9e-12 45.2 0.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESL09417.1 - 2.8e-08 33.2 2.7 4e-08 32.8 1.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL09417.1 - 3.6e-08 33.2 6.6 5.4e-08 32.7 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL09417.1 - 7.5e-08 31.9 5.0 1.1e-07 31.3 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL09417.1 - 4.9e-07 29.3 4.1 7.1e-07 28.8 2.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESL09417.1 - 0.00013 21.7 3.8 0.0004 20.1 2.6 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 ESL09417.1 - 0.0075 16.2 5.5 0.014 15.4 3.8 1.4 1 0 0 1 1 1 1 RING-variant domain Rtf2 PF04641.7 ESL09417.1 - 0.0079 15.4 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger PHD PF00628.24 ESL09417.1 - 0.012 15.3 3.5 0.019 14.6 2.4 1.4 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 ESL09417.1 - 0.018 14.8 3.6 0.042 13.7 2.5 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESL09417.1 - 0.025 14.2 4.1 0.05 13.3 2.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.3 ESL09417.1 - 0.05 13.5 3.6 0.12 12.3 2.5 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.1 ESL09417.1 - 0.073 12.6 3.7 0.13 11.8 2.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 ESL09417.1 - 0.27 10.7 2.6 0.45 10.0 1.8 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Abhydrolase_2 PF02230.11 ESL09419.1 - 5.9e-42 143.5 0.0 7.7e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 ESL09419.1 - 1.2e-11 44.5 0.1 2.1e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL09419.1 - 5.1e-09 36.3 1.1 0.00018 21.4 0.3 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESL09419.1 - 2.2e-06 27.0 0.0 0.00034 19.9 0.0 2.8 3 0 0 3 3 3 1 Prolyl oligopeptidase family Cutinase PF01083.17 ESL09419.1 - 0.00099 18.8 0.6 0.033 13.9 0.1 2.2 1 1 1 2 2 2 1 Cutinase LIP PF03583.9 ESL09419.1 - 0.0021 17.2 1.2 0.014 14.6 0.0 2.1 1 1 1 2 2 2 1 Secretory lipase Abhydro_lipase PF04083.11 ESL09419.1 - 0.0023 17.2 0.1 0.3 10.4 0.1 2.8 2 1 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region DLH PF01738.13 ESL09419.1 - 0.0034 16.6 0.0 0.0062 15.8 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Esterase_phd PF10503.4 ESL09419.1 - 0.016 14.4 0.8 0.073 12.3 0.3 1.9 1 1 1 2 2 2 0 Esterase PHB depolymerase AXE1 PF05448.7 ESL09419.1 - 0.048 12.1 0.5 0.16 10.4 0.1 1.8 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) FSH1 PF03959.8 ESL09419.1 - 0.1 12.0 0.1 0.19 11.1 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Hydrolase_4 PF12146.3 ESL09419.1 - 0.12 12.2 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 Putative lysophospholipase Peptidase_C2 PF00648.16 ESL09420.1 - 5e-30 104.5 0.0 8.7e-30 103.7 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 ESL09420.1 - 1.5e-11 44.1 0.0 4.9e-09 35.9 0.0 3.4 2 1 0 2 2 2 1 Calpain large subunit, domain III TPR_11 PF13414.1 ESL09421.1 - 4.4e-31 106.3 9.3 6.4e-09 35.3 0.0 5.8 3 1 6 9 9 9 8 TPR repeat TPR_2 PF07719.12 ESL09421.1 - 9.6e-28 93.8 9.1 0.00021 20.9 0.1 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09421.1 - 8.6e-26 88.4 0.7 2.9e-05 23.4 0.1 6.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESL09421.1 - 1.4e-20 72.9 13.4 1.4e-05 24.9 0.2 6.3 3 1 5 8 8 8 7 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09421.1 - 7.5e-20 69.6 15.8 0.00065 20.1 0.1 9.4 3 2 7 10 10 9 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09421.1 - 3.6e-18 65.7 10.2 0.0001 22.8 0.0 6.2 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESL09421.1 - 7.5e-18 64.6 9.6 9.5e-06 25.8 0.2 6.2 4 2 3 7 7 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESL09421.1 - 1e-15 56.5 4.5 0.00078 19.4 0.0 7.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESL09421.1 - 4e-14 52.2 9.6 6e-05 22.8 0.2 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09421.1 - 2.6e-12 45.5 0.0 0.45 10.4 0.0 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESL09421.1 - 6e-12 44.4 11.4 0.13 12.0 0.0 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat Apc3 PF12895.2 ESL09421.1 - 2.8e-10 40.1 10.2 0.0095 16.0 1.3 5.4 2 1 3 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESL09421.1 - 1.4e-08 34.6 13.4 0.13 12.8 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESL09421.1 - 2.4e-07 30.4 15.8 0.56 10.2 0.1 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL09421.1 - 0.0001 22.1 3.0 0.3 10.9 0.0 4.4 4 1 1 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.1 ESL09421.1 - 0.00021 20.4 6.2 0.0059 15.7 0.4 3.8 1 1 2 4 4 4 1 Tetratricopeptide repeat Coatomer_E PF04733.9 ESL09421.1 - 0.0089 15.2 3.5 0.08 12.1 1.0 3.1 1 1 1 2 2 2 1 Coatomer epsilon subunit Apc5 PF12862.2 ESL09421.1 - 0.017 14.9 3.2 0.72 9.7 0.0 3.9 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 5 ChAPs PF09295.5 ESL09421.1 - 0.032 12.9 0.9 2.7 6.6 0.3 2.7 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.3 ESL09421.1 - 0.061 12.0 1.3 12 4.5 0.0 2.8 1 1 2 3 3 3 0 NMDA receptor-regulated protein 1 TPR_20 PF14561.1 ESL09421.1 - 0.13 12.3 4.1 3.3 7.8 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat D123 PF07065.9 ESL09423.1 - 8e-09 34.9 0.0 1.2e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 D123 M_domain PF12938.2 ESL09424.1 - 0.043 13.6 1.4 0.14 11.9 0.9 1.9 1 0 0 1 1 1 0 M domain of GW182 AAA_13 PF13166.1 ESL09424.1 - 0.069 11.6 0.4 0.12 10.8 0.3 1.3 1 0 0 1 1 1 0 AAA domain DUF948 PF06103.6 ESL09424.1 - 0.22 11.4 1.9 1.7 8.5 0.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) EMP24_GP25L PF01105.19 ESL09424.1 - 0.8 9.3 4.3 2.7 7.6 0.1 2.8 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD Occludin_ELL PF07303.8 ESL09424.1 - 1.2 9.9 3.1 9.7 6.9 0.0 2.9 3 0 0 3 3 3 0 Occludin homology domain DUF4349 PF14257.1 ESL09424.1 - 1.2 8.3 14.9 0.37 9.9 4.8 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) XhlA PF10779.4 ESL09424.1 - 2.6 8.0 6.4 0.32 10.9 0.7 2.3 2 0 0 2 2 2 0 Haemolysin XhlA DUF4520 PF15016.1 ESL09426.1 - 0.0041 16.6 0.1 0.0072 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4520) Cmc1 PF08583.5 ESL09426.1 - 0.0041 16.8 3.9 0.0041 16.8 2.7 2.4 3 0 0 3 3 3 1 Cytochrome c oxidase biogenesis protein Cmc1 like Med15_fungi PF05397.7 ESL09426.1 - 0.0064 16.4 0.2 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 Mediator complex subunit 15 TfoX_N PF04993.8 ESL09426.1 - 0.17 11.7 0.2 0.17 11.7 0.2 2.3 2 1 0 2 2 2 0 TfoX N-terminal domain LHH PF14411.1 ESL09426.1 - 0.59 10.3 3.8 16 5.8 0.4 2.6 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH UPF0203 PF05254.7 ESL09426.1 - 0.61 9.9 5.1 0.32 10.8 1.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Ank_5 PF13857.1 ESL09428.1 - 6.5e-16 57.9 4.6 4.5e-08 33.0 0.6 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESL09428.1 - 1.1e-15 57.7 1.0 3.4e-15 56.1 0.7 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESL09428.1 - 2.4e-15 55.4 6.5 5.3e-07 29.1 0.4 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESL09428.1 - 5e-15 55.5 3.9 1.5e-10 41.2 0.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL09428.1 - 6.6e-10 38.2 3.5 0.0014 18.6 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat Chromo PF00385.19 ESL09428.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain LRR_4 PF12799.2 ESL09429.1 - 1.4e-06 27.7 0.1 0.00011 21.7 0.0 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL09429.1 - 2.6e-05 23.9 0.9 0.013 15.2 0.1 2.2 1 1 0 2 2 2 2 Leucine rich repeat LRR_9 PF14580.1 ESL09429.1 - 0.0018 17.9 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_7 PF13504.1 ESL09429.1 - 0.0089 16.0 0.1 14 6.4 0.0 3.4 3 1 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 ESL09429.1 - 0.049 13.6 0.0 23 5.5 0.0 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat BUD22 PF09073.5 ESL09429.1 - 0.073 12.1 4.6 0.088 11.8 3.2 1.1 1 0 0 1 1 1 0 BUD22 Sigma70_ner PF04546.8 ESL09429.1 - 0.9 9.1 5.2 1.3 8.5 3.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region SDA1 PF05285.7 ESL09429.1 - 3.5 6.8 7.4 5 6.3 5.1 1.1 1 0 0 1 1 1 0 SDA1 NAD_binding_2 PF03446.10 ESL09430.1 - 2.8e-54 183.3 0.3 5e-54 182.5 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 ESL09430.1 - 5.7e-37 126.4 1.4 1.1e-36 125.5 0.9 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 3HCDH_N PF02737.13 ESL09430.1 - 7.9e-06 25.6 0.4 0.00032 20.4 0.1 2.8 2 1 1 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 ESL09430.1 - 8.1e-06 25.9 0.2 2e-05 24.7 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 ESL09430.1 - 8.2e-06 25.0 0.9 6.7e-05 22.1 0.0 2.5 2 1 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 ESL09430.1 - 8.8e-06 26.0 1.0 3.9e-05 24.0 0.0 2.4 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.4 ESL09430.1 - 0.0038 16.9 0.1 0.0093 15.6 0.0 1.7 2 0 0 2 2 2 1 Rossmann-like domain NAD_binding_10 PF13460.1 ESL09430.1 - 0.0057 16.6 0.1 0.036 14.0 0.1 2.4 1 1 0 1 1 1 1 NADH(P)-binding ApbA PF02558.11 ESL09430.1 - 0.0095 15.3 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.7 ESL09430.1 - 0.011 15.1 0.1 0.03 13.7 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_N PF03721.9 ESL09430.1 - 0.022 14.1 0.0 3.6 6.9 0.0 2.4 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.16 ESL09432.1 - 2.2e-34 118.1 0.0 5.6e-34 116.8 0.0 1.7 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.4 ESL09432.1 - 4.5e-16 57.9 0.9 7.9e-16 57.1 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 ESL09432.1 - 0.00084 19.4 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 ESL09432.1 - 0.0086 16.3 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox PF00070.22 ESL09432.1 - 0.11 12.9 0.3 0.32 11.4 0.2 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MMR_HSR1 PF01926.18 ESL09433.1 - 6.6e-13 48.6 0.0 1.2e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL09433.1 - 8.3e-10 38.1 0.0 1.1e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESL09433.1 - 0.00014 21.6 0.6 0.018 14.8 0.1 2.3 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.11 ESL09433.1 - 0.0026 16.9 0.0 0.0046 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESL09433.1 - 0.0029 17.0 0.1 0.16 11.3 0.1 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 ESL09433.1 - 0.0037 16.5 0.0 0.0072 15.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_28 PF13521.1 ESL09433.1 - 0.015 15.2 4.5 0.83 9.5 0.0 3.7 3 2 1 4 4 4 0 AAA domain AAA_21 PF13304.1 ESL09433.1 - 0.018 15.0 0.1 0.031 14.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 ESL09433.1 - 0.067 11.8 0.0 0.33 9.5 0.0 1.9 2 0 0 2 2 2 0 G-protein alpha subunit AAA_23 PF13476.1 ESL09433.1 - 0.079 13.2 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.11 ESL09433.1 - 0.084 11.9 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 AIG1 family dUTPase_2 PF08761.6 ESL09434.1 - 4.7e-37 127.6 0.0 6.6e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 dUTPase RRM_5 PF13893.1 ESL09435.1 - 1.4e-10 40.8 0.2 1.8e-05 24.5 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL09435.1 - 0.0017 18.2 0.3 0.94 9.5 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL09435.1 - 0.023 14.3 0.0 5.8 6.6 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-TRAF PF02176.13 ESL09437.1 - 0.0095 16.2 1.1 0.0095 16.2 0.7 3.2 3 1 1 4 4 4 2 TRAF-type zinc finger UPF0547 PF10571.4 ESL09437.1 - 0.063 12.9 3.6 4.7 6.9 0.2 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 DZR PF12773.2 ESL09437.1 - 0.15 11.8 9.3 15 5.5 6.4 2.9 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESL09437.1 - 0.65 9.2 6.1 1.6 8.0 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-Di19 PF05605.7 ESL09437.1 - 1 9.5 12.7 0.32 11.1 0.6 3.9 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_2 PF13240.1 ESL09437.1 - 1.9 8.0 6.0 11 5.6 0.1 3.7 4 0 0 4 4 4 0 zinc-ribbon domain IBR PF01485.16 ESL09437.1 - 2.4 8.0 8.5 1.2e+02 2.6 5.9 2.8 1 1 0 1 1 1 0 IBR domain SGS PF05002.10 ESL09438.1 - 8.6e-28 95.9 0.6 1.4e-27 95.1 0.4 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.11 ESL09438.1 - 5.5e-08 33.2 0.0 1e-07 32.3 0.0 1.5 2 0 0 2 2 2 1 CS domain DUF2158 PF09926.4 ESL09438.1 - 0.007 15.7 0.0 0.03 13.7 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized small protein (DUF2158) SseB PF07179.7 ESL09438.1 - 0.13 12.0 0.1 1.8 8.3 0.0 2.2 2 0 0 2 2 2 0 SseB protein N-terminal domain DNA_ligase_A_M PF01068.16 ESL09439.1 - 1.1e-19 70.5 0.0 7.8e-19 67.8 0.0 2.0 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.1 ESL09439.1 - 3.8e-18 64.9 0.1 6.5e-18 64.1 0.1 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain DUF4379 PF14311.1 ESL09439.1 - 0.0013 18.4 3.9 0.0013 18.4 2.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4379) mRNA_cap_enzyme PF01331.14 ESL09439.1 - 0.043 13.5 0.0 0.28 10.8 0.0 2.2 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain Pkinase PF00069.20 ESL09441.1 - 1.3e-48 165.4 0.0 3e-48 164.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09441.1 - 4.1e-30 104.7 0.0 6.4e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09441.1 - 2e-06 26.9 0.0 3.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL09441.1 - 0.012 15.3 0.0 0.012 15.3 0.0 2.3 3 1 0 3 3 3 0 Phosphotransferase enzyme family Snf7 PF03357.16 ESL09442.1 - 2.2e-27 95.4 29.8 2.2e-27 95.4 20.7 1.8 1 1 1 2 2 2 1 Snf7 rpo30_N PF12410.3 ESL09442.1 - 0.013 15.1 1.3 0.02 14.5 0.9 1.3 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit V_ATPase_I PF01496.14 ESL09442.1 - 7.8 4.2 12.9 9.9 3.8 8.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LRR_6 PF13516.1 ESL09443.1 - 1e-23 80.6 10.4 8.1e-05 22.2 0.0 8.4 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.2 ESL09443.1 - 1.5e-09 37.2 1.5 0.0044 16.6 0.0 4.0 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL09443.1 - 1.9e-06 27.0 4.7 3.5 8.0 0.0 6.1 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_8 PF13855.1 ESL09443.1 - 0.011 15.4 5.1 0.54 10.0 0.2 4.2 4 2 2 6 6 6 0 Leucine rich repeat LRR_7 PF13504.1 ESL09443.1 - 0.02 14.9 4.2 61 4.4 0.0 5.4 5 0 0 5 5 5 0 Leucine rich repeat PhaC_N PF07167.8 ESL09443.1 - 0.092 12.1 0.1 0.38 10.1 0.0 1.9 2 0 0 2 2 2 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Complex1_LYR PF05347.10 ESL09444.1 - 4.8e-05 23.0 0.5 0.00025 20.7 0.3 2.0 1 1 0 1 1 1 1 Complex 1 protein (LYR family) RyR PF02026.11 ESL09444.1 - 0.1 12.6 0.4 0.38 10.8 0.0 2.0 2 1 0 2 2 2 0 RyR domain SpoIISA_toxin PF14171.1 ESL09444.1 - 0.1 11.8 0.1 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system SET PF00856.23 ESL09445.1 - 0.0001 22.6 0.2 0.0062 16.8 0.1 2.2 1 1 2 3 3 3 2 SET domain Synaptonemal_3 PF15191.1 ESL09445.1 - 0.048 13.4 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 Sod_Fe_C PF02777.13 ESL09446.1 - 1.8e-09 37.3 0.1 4.2e-09 36.1 0.0 1.6 1 1 1 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 ESL09446.1 - 1.1e-06 28.7 0.0 1.9e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Y_phosphatase2 PF03162.8 ESL09447.1 - 1.4e-38 131.8 0.0 1.9e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESL09447.1 - 3.3e-06 27.4 0.0 4.5e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family MauE PF07291.6 ESL09447.1 - 0.07 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Methylamine utilisation protein MauE Nucleoside_tran PF01733.13 ESL09448.1 - 3.2e-29 102.0 6.8 5.7e-29 101.2 4.7 1.4 1 0 0 1 1 1 1 Nucleoside transporter His_Phos_1 PF00300.17 ESL09449.1 - 1.6e-09 38.0 0.0 3.7e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) LicD PF04991.8 ESL09450.1 - 1.6e-10 41.4 0.0 2.5e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 LicD family DUF4050 PF13259.1 ESL09450.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) HAD PF12710.2 ESL09450.1 - 0.11 12.6 0.1 0.15 12.2 0.1 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase PDEase_I PF00233.14 ESL09452.1 - 6.8e-11 42.3 1.0 6e-10 39.2 0.7 2.1 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Peptidase_M8 PF01457.11 ESL09453.1 - 1.2e-120 403.3 0.0 1.4e-120 403.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Pkinase PF00069.20 ESL09454.1 - 9.9e-36 123.2 0.0 1.4e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09454.1 - 2.8e-18 65.9 0.0 3.9e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09454.1 - 0.0015 17.5 0.0 0.0021 17.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 ESL09454.1 - 0.0061 15.4 0.0 0.01 14.6 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 ESL09454.1 - 0.01 14.8 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL09454.1 - 0.08 12.6 0.2 0.18 11.5 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Tim17 PF02466.14 ESL09455.1 - 1.7e-20 73.3 0.3 2.5e-20 72.7 0.2 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Adap_comp_sub PF00928.16 ESL09456.1 - 4.3e-57 193.1 0.0 5.3e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESL09456.1 - 0.0007 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ECH PF00378.15 ESL09457.1 - 1.7e-20 73.1 0.0 4.5e-20 71.8 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family Ribosomal_L6e PF01159.14 ESL09459.1 - 9e-35 119.1 0.7 2.2e-34 117.9 0.5 1.7 1 1 0 1 1 1 1 Ribosomal protein L6e KOW PF00467.24 ESL09459.1 - 0.0033 17.0 0.1 0.024 14.3 0.0 2.4 3 0 0 3 3 3 1 KOW motif DUF4230 PF14014.1 ESL09459.1 - 0.26 11.1 3.8 0.093 12.5 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) RWD PF05773.17 ESL09460.1 - 6.2e-08 32.5 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain DUF3807 PF12720.2 ESL09460.1 - 0.065 13.3 0.1 0.095 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DivIC PF04977.10 ESL09460.1 - 0.066 12.7 0.3 0.19 11.1 0.1 1.8 1 1 0 1 1 1 0 Septum formation initiator NAAA-beta PF15508.1 ESL09460.1 - 0.11 12.8 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase MIF4G PF02854.14 ESL09461.1 - 2.8e-16 59.5 0.4 4.4e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 MIF4G domain FTA4 PF13093.1 ESL09461.1 - 0.036 13.4 0.1 0.058 12.8 0.1 1.3 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Ras PF00071.17 ESL09462.1 - 6.6e-36 123.1 0.1 8e-36 122.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL09462.1 - 3.4e-18 66.2 0.0 6e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL09462.1 - 2.1e-09 36.8 0.0 2.7e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL09462.1 - 8.7e-09 34.8 0.1 1.1e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESL09462.1 - 5.2e-06 26.0 0.0 0.00015 21.2 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL09462.1 - 1.1e-05 25.3 0.0 3.8e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESL09462.1 - 2.9e-05 23.3 0.0 5.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 ESL09462.1 - 0.0012 18.4 0.2 0.0021 17.6 0.1 1.4 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 ESL09462.1 - 0.023 14.8 0.0 0.72 10.0 0.0 2.2 1 1 1 2 2 2 0 AAA domain CPT PF07931.7 ESL09463.1 - 0.09 12.3 0.1 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Laminin_G_2 PF02210.19 ESL09463.1 - 0.18 11.8 0.0 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Laminin G domain tRNA-synt_1c PF00749.16 ESL09464.1 - 9.1e-99 330.0 0.0 1.2e-98 329.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DUF1465 PF07323.7 ESL09464.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) HPP PF04982.8 ESL09465.1 - 3e-16 59.3 7.8 3.4e-16 59.1 5.4 1.0 1 0 0 1 1 1 1 HPP family SecE PF00584.15 ESL09465.1 - 5.2 6.7 10.2 3.6 7.2 0.3 2.9 3 0 0 3 3 3 0 SecE/Sec61-gamma subunits of protein translocation complex DUF21 PF01595.15 ESL09465.1 - 6.1 6.0 6.1 32 3.7 4.3 2.0 1 1 0 1 1 1 0 Domain of unknown function DUF21 DUF1771 PF08590.5 ESL09466.1 - 0.062 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) APG6 PF04111.7 ESL09467.1 - 0.00048 19.2 9.5 0.00048 19.2 6.6 2.0 1 1 1 2 2 2 1 Autophagy protein Apg6 DUF3053 PF11254.3 ESL09467.1 - 0.065 12.4 3.5 0.45 9.7 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3053) ADIP PF11559.3 ESL09467.1 - 0.31 10.9 24.5 0.13 12.1 2.9 2.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Lge1 PF11488.3 ESL09467.1 - 0.68 10.1 11.2 1.3 9.2 0.8 3.1 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 Tnp_P_element PF12017.3 ESL09467.1 - 1.4 8.0 9.5 0.32 10.1 0.3 2.9 2 1 0 3 3 3 0 Transposase protein Med21 PF11221.3 ESL09467.1 - 2.6 8.0 15.9 0.22 11.5 1.7 3.2 3 0 0 3 3 3 0 Subunit 21 of Mediator complex UPF0449 PF15136.1 ESL09467.1 - 4.5 7.5 9.6 2.9 8.1 0.1 3.5 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 DUF3294 PF07957.6 ESL09468.1 - 0.0029 17.1 3.0 0.0055 16.2 2.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) Tropomyosin PF00261.15 ESL09468.1 - 0.022 13.8 4.1 0.043 12.9 2.8 1.4 1 0 0 1 1 1 0 Tropomyosin DUF1796 PF08795.5 ESL09469.1 - 8.6e-50 168.6 0.0 1.6e-49 167.7 0.0 1.5 1 0 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) Claudin_2 PF13903.1 ESL09470.1 - 0.0036 17.0 9.3 0.004 16.8 5.7 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2079 PF09852.4 ESL09470.1 - 0.018 13.8 1.5 0.034 12.8 1.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) Galactosyl_T PF01762.16 ESL09471.1 - 0.00047 19.8 0.0 0.48 9.9 0.0 3.0 3 0 0 3 3 3 2 Galactosyltransferase Vps26 PF03643.10 ESL09473.1 - 4e-58 196.3 0.6 5e-58 196.0 0.4 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 ESL09473.1 - 2.4e-06 27.4 0.4 0.13 12.0 0.0 3.2 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain CCDC32 PF14989.1 ESL09474.1 - 0.047 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Coiled-coil domain containing 32 Med3 PF11593.3 ESL09474.1 - 0.86 8.7 3.5 1.9 7.6 2.4 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal EF-hand_7 PF13499.1 ESL09475.1 - 5.5e-10 39.2 1.0 3e-09 36.8 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL09475.1 - 4.7e-08 31.7 0.3 0.00089 18.3 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESL09475.1 - 1.8e-07 30.4 0.2 0.00085 19.0 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 ESL09475.1 - 4.2e-07 29.4 0.5 0.0012 18.3 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.1 ESL09475.1 - 0.024 14.3 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 EF hand SPARC_Ca_bdg PF10591.4 ESL09475.1 - 0.045 13.7 0.2 0.083 12.9 0.1 1.7 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region NLE PF08154.7 ESL09475.1 - 0.12 12.3 0.0 1.7 8.7 0.0 2.3 2 0 0 2 2 2 0 NLE (NUC135) domain DUF4349 PF14257.1 ESL09476.1 - 0.21 10.8 3.4 0.055 12.6 0.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) PAP_assoc PF03828.14 ESL09477.1 - 0.084 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Cid1 family poly A polymerase tRNA_NucTransf2 PF09249.6 ESL09477.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain Aa_trans PF01490.13 ESL09479.1 - 6e-47 160.0 30.7 6.8e-47 159.8 21.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL09479.1 - 1.4e-06 27.4 15.3 3.5e-06 26.0 10.5 1.8 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family Zeta_toxin PF06414.7 ESL09480.1 - 3.4e-14 52.4 0.0 7.8e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 ESL09480.1 - 0.00056 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09480.1 - 0.01 16.6 0.0 0.037 14.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 ESL09480.1 - 0.021 15.1 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF4131 PF13567.1 ESL09481.1 - 0.42 9.9 8.5 1.8 7.9 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) ADH_N PF08240.7 ESL09482.1 - 4.6e-24 84.2 0.1 4.6e-24 84.2 0.0 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESL09482.1 - 1e-18 67.1 0.3 1.7e-18 66.4 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESL09482.1 - 2.3e-05 25.3 0.0 4.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.19 ESL09482.1 - 0.017 15.4 0.2 0.13 12.6 0.1 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_N PF00044.19 ESL09482.1 - 0.031 14.2 0.0 0.075 12.9 0.0 1.7 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 ESL09482.1 - 0.044 13.1 0.5 0.072 12.4 0.4 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 ESL09482.1 - 0.047 13.3 0.4 0.075 12.6 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peripla_BP_6 PF13458.1 ESL09482.1 - 0.052 12.9 0.4 0.16 11.2 0.1 1.8 2 0 0 2 2 2 0 Periplasmic binding protein DAO PF01266.19 ESL09482.1 - 0.41 9.4 3.2 0.79 8.5 2.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pkinase PF00069.20 ESL09483.1 - 6.2e-54 182.8 0.0 1.3e-53 181.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09483.1 - 7e-32 110.5 0.0 3e-30 105.1 0.0 2.8 3 0 0 3 3 3 1 Protein tyrosine kinase HEAT_2 PF13646.1 ESL09483.1 - 0.00082 19.6 3.2 0.0063 16.7 0.3 3.7 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.17 ESL09483.1 - 0.0032 17.4 2.8 31 5.0 0.0 5.5 5 0 0 5 5 5 0 HEAT repeat DUF1902 PF08972.6 ESL09483.1 - 0.022 14.2 0.1 0.093 12.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) RIO1 PF01163.17 ESL09483.1 - 0.034 13.5 0.2 1.7 7.9 0.0 2.3 2 0 0 2 2 2 0 RIO1 family CHB_HEX_C PF03174.8 ESL09484.1 - 8.9e-06 25.4 0.4 2.1e-05 24.2 0.3 1.6 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C_1 PF13290.1 ESL09484.1 - 0.00032 20.4 0.9 0.00075 19.2 0.6 1.6 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 ESL09484.1 - 0.0048 16.9 0.1 0.013 15.5 0.1 1.7 1 0 0 1 1 1 1 Fn3 associated Ribosomal_L18ae PF01775.12 ESL09488.1 - 1e-38 131.9 0.6 1.4e-38 131.5 0.4 1.2 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain NAD_binding_6 PF08030.7 ESL09489.1 - 0.083 12.7 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Thioredoxin_8 PF13905.1 ESL09491.1 - 2.4e-20 72.4 0.0 3.1e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 ESL09491.1 - 8.2e-09 35.6 0.0 1.2e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 ESL09491.1 - 3.6e-07 29.8 0.0 5.3e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.15 ESL09491.1 - 8.8e-07 28.5 0.0 0.00026 20.6 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.5 ESL09491.1 - 4.6e-05 22.9 0.0 5.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.1 ESL09491.1 - 0.00011 22.1 0.1 0.00071 19.5 0.0 2.1 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESL09491.1 - 0.033 13.7 0.0 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin DUF501 PF04417.7 ESL09492.1 - 4.1e-31 107.6 0.1 6e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF501) FMO-like PF00743.14 ESL09493.1 - 3.7e-22 78.2 0.0 1.5e-17 62.9 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 ESL09493.1 - 2.3e-15 57.2 0.0 4.8e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 ESL09493.1 - 8.7e-09 34.7 0.0 4.7e-06 25.7 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 ESL09493.1 - 0.00015 21.7 0.0 0.0053 16.6 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 ESL09493.1 - 0.076 13.2 0.0 0.24 11.6 0.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.22 ESL09493.1 - 0.18 12.2 0.0 12 6.3 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Hyd_WA PF06462.7 ESL09494.1 - 0.011 15.3 0.3 0.024 14.2 0.2 1.5 1 0 0 1 1 1 0 Propeller PLDc_2 PF13091.1 ESL09495.1 - 7.7e-10 38.5 0.0 0.00018 21.2 0.0 2.9 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.17 ESL09495.1 - 0.021 14.5 2.0 0.15 11.9 0.1 2.7 2 1 0 2 2 2 0 Phospholipase D Active site motif WD40 PF00400.27 ESL09496.1 - 2.2e-35 119.2 20.2 1.9e-08 33.8 0.0 13.3 13 1 0 13 13 13 8 WD domain, G-beta repeat 3Beta_HSD PF01073.14 ESL09497.1 - 6.9e-16 57.7 0.0 8.8e-16 57.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ESL09497.1 - 3.4e-11 43.0 0.0 4.5e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL09497.1 - 0.00039 19.3 0.0 0.0005 19.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 ESL09497.1 - 0.12 11.2 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein SlyX PF04102.7 ESL09498.1 - 1.3e-05 25.4 16.3 1.8e-05 25.0 0.9 2.8 3 0 0 3 3 3 2 SlyX zf-RING_2 PF13639.1 ESL09498.1 - 0.0093 15.7 4.3 0.04 13.7 3.0 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESL09498.1 - 0.087 12.5 6.7 0.068 12.8 0.7 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DP PF08781.5 ESL09498.1 - 0.098 12.3 2.4 0.19 11.3 1.7 1.4 1 0 0 1 1 1 0 Transcription factor DP Neur_chan_memb PF02932.11 ESL09498.1 - 0.3 10.9 2.2 0.5 10.2 1.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PALP PF00291.20 ESL09499.1 - 1.2e-13 50.9 0.0 3.8e-13 49.3 0.0 1.8 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_synth_N PF14821.1 ESL09499.1 - 1.1e-10 41.3 0.0 2.6e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus Metal_resist PF13801.1 ESL09500.1 - 0.37 10.7 7.4 3.5 7.6 0.3 2.5 3 0 0 3 3 3 0 Heavy-metal resistance HSCB_C PF07743.8 ESL09500.1 - 7.6 7.0 7.7 2.3 8.7 1.0 2.3 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain Ribosomal_S24e PF01282.14 ESL09501.1 - 1.6e-28 98.3 0.0 2.9e-28 97.4 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e Acylphosphatase PF00708.13 ESL09502.1 - 1.6e-25 89.0 0.0 1.6e-25 88.9 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase ProRS-C_1 PF09180.6 ESL09503.1 - 1.9e-25 88.5 1.7 1.9e-25 88.5 1.2 2.1 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA_edit PF04073.10 ESL09503.1 - 3.3e-23 81.8 0.3 6e-23 81.0 0.2 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2b PF00587.20 ESL09503.1 - 1.3e-18 67.2 0.1 2.4e-18 66.3 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESL09503.1 - 4.1e-15 55.5 0.0 9e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Ustilago_mating PF05722.7 ESL09503.1 - 0.055 12.7 0.1 0.091 12.0 0.0 1.3 1 0 0 1 1 1 0 Ustilago B locus mating-type protein TPR_11 PF13414.1 ESL09504.1 - 3.4e-14 52.2 6.7 2e-07 30.5 1.1 2.8 3 0 0 3 3 3 2 TPR repeat TPR_1 PF00515.23 ESL09504.1 - 1.3e-11 43.6 6.5 0.00061 19.2 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL09504.1 - 2.4e-10 39.5 7.4 0.0024 17.6 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09504.1 - 8.7e-07 29.4 1.6 0.029 15.0 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09504.1 - 0.00011 21.7 3.3 1.8 8.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL09504.1 - 0.00086 19.2 3.5 0.25 11.3 0.6 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL09504.1 - 0.0067 16.8 1.7 1.7 9.3 0.2 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09504.1 - 0.025 15.1 0.4 0.76 10.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.12 ESL09504.1 - 0.044 14.0 0.1 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_17 PF13431.1 ESL09504.1 - 0.14 12.3 0.7 2.2 8.6 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL09504.1 - 0.51 10.5 7.2 1.9 8.6 2.1 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_7 PF13499.1 ESL09505.1 - 1.1e-17 63.9 0.0 0.00012 22.1 0.0 4.8 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 ESL09505.1 - 2.3e-16 57.7 0.0 7.6e-05 21.7 0.0 5.2 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 ESL09505.1 - 8e-15 53.3 5.8 0.00041 20.0 0.2 6.4 7 0 0 7 7 7 3 EF-hand domain EF-hand_8 PF13833.1 ESL09505.1 - 2.7e-11 42.8 1.8 0.23 11.0 0.0 5.4 6 0 0 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.1 ESL09505.1 - 1.7e-08 33.4 1.7 0.0001 21.4 0.1 5.4 6 0 0 6 6 6 1 EF hand EF-hand_4 PF12763.2 ESL09505.1 - 2.1e-05 24.2 0.2 0.00035 20.2 0.0 2.7 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESL09505.1 - 0.015 15.3 0.2 0.092 12.7 0.0 2.2 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Ribosomal_L33 PF00471.15 ESL09506.1 - 0.075 13.2 0.2 0.14 12.4 0.2 1.6 1 1 0 1 1 1 0 Ribosomal protein L33 Occludin_ELL PF07303.8 ESL09507.1 - 0.33 11.7 1.6 2.3 9.0 0.2 2.4 2 0 0 2 2 2 0 Occludin homology domain DUF4200 PF13863.1 ESL09507.1 - 0.62 10.0 5.2 2.6 7.9 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) ATP_bind_4 PF01902.12 ESL09508.1 - 1.3e-28 99.8 0.0 1.1e-27 96.7 0.0 2.1 1 1 0 1 1 1 1 ATP-binding region Glyco_trans_1_4 PF13692.1 ESL09508.1 - 0.11 12.6 0.1 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 Gtr1_RagA PF04670.7 ESL09509.1 - 2.2e-65 220.0 0.0 2.8e-65 219.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESL09509.1 - 0.00015 22.2 0.0 0.0013 19.1 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESL09509.1 - 0.0003 20.0 0.0 0.00091 18.5 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESL09509.1 - 0.00033 20.6 0.0 0.00071 19.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Pro-rich_19 PF15455.1 ESL09509.1 - 0.0077 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Proline-rich 19 PGK PF00162.14 ESL09510.1 - 1.5e-151 504.3 0.0 1.7e-151 504.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PgaD PF13994.1 ESL09511.1 - 0.13 11.7 0.1 0.17 11.3 0.1 1.2 1 0 0 1 1 1 0 PgaD-like protein Mre11_DNA_bind PF04152.9 ESL09512.1 - 2.3e-30 105.7 0.0 3.7e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 ESL09512.1 - 1.2e-18 67.2 1.1 1.6e-18 66.8 0.8 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase C-C_Bond_Lyase PF15617.1 ESL09513.1 - 0.059 12.1 0.1 0.098 11.4 0.1 1.3 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold Ribosomal_L16 PF00252.13 ESL09514.1 - 1.8e-27 95.6 0.4 2.4e-27 95.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Peptidase_M18 PF02127.10 ESL09515.1 - 5.3e-154 512.8 0.0 6.2e-154 512.6 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 ESL09515.1 - 7.9e-09 34.6 0.0 1.4e-06 27.3 0.0 2.2 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase DUF812 PF05667.6 ESL09516.1 - 0.009 14.5 10.1 0.02 13.4 2.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF812) DUF948 PF06103.6 ESL09516.1 - 0.24 11.3 1.7 2.1 8.2 0.1 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF972 PF06156.8 ESL09516.1 - 5.6 7.3 7.1 3.7 7.9 1.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Vps39_1 PF10366.4 ESL09517.1 - 2.2e-21 75.9 0.0 1.7e-17 63.3 0.0 2.6 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 ESL09517.1 - 2.3e-19 69.5 0.0 7.4e-19 67.9 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.17 ESL09517.1 - 6.8e-11 42.1 0.0 1.1e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.15 ESL09517.1 - 1.6e-07 31.0 0.0 0.0001 21.9 0.0 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS DUF2175 PF09943.4 ESL09517.1 - 0.084 12.9 0.3 0.26 11.3 0.2 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) E1-E2_ATPase PF00122.15 ESL09518.1 - 1.6e-58 197.4 5.2 5.6e-58 195.6 4.0 1.6 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESL09518.1 - 4.1e-24 86.1 0.0 1.7e-23 84.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESL09518.1 - 1.4e-13 50.1 0.0 3.2e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 ESL09518.1 - 2.4e-13 50.7 0.0 8.7e-13 48.8 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL09518.1 - 0.00012 21.8 0.1 0.00069 19.2 0.0 2.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL09518.1 - 0.031 14.2 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit Thioredoxin_6 PF13848.1 ESL09519.1 - 5.8e-21 75.1 0.0 1.6e-13 50.8 0.0 2.0 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.15 ESL09519.1 - 6.2e-16 57.9 0.0 3e-13 49.3 0.0 3.2 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL09519.1 - 1.9e-05 24.8 0.1 0.00023 21.3 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like domain Calsequestrin PF01216.12 ESL09519.1 - 0.00035 19.4 0.0 0.0005 18.9 0.0 1.1 1 0 0 1 1 1 1 Calsequestrin HyaE PF07449.6 ESL09519.1 - 0.025 14.4 0.0 0.094 12.6 0.0 2.0 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.1 ESL09519.1 - 0.045 13.8 0.0 0.72 10.0 0.0 2.6 3 0 0 3 3 3 0 Thioredoxin-like Thioredoxin_8 PF13905.1 ESL09521.1 - 8e-05 22.6 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_31 PF01055.21 ESL09522.1 - 9.9e-94 314.6 0.0 1.5e-93 314.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NOB1_Zn_bind PF08772.6 ESL09523.1 - 9.8e-27 92.5 1.2 1.9e-26 91.6 0.8 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like AF1Q PF15017.1 ESL09523.1 - 0.012 15.4 14.5 0.034 14.0 10.1 1.7 1 1 0 1 1 1 0 Drug resistance and apoptosis regulator zf-NADH-PPase PF09297.6 ESL09523.1 - 0.65 9.5 4.4 0.91 9.0 0.9 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF3664 PF12406.3 ESL09523.1 - 0.74 10.4 10.2 1.3 9.6 7.0 1.3 1 0 0 1 1 1 0 Surface protein Daxx PF03344.10 ESL09523.1 - 3 6.2 8.9 4.3 5.7 6.2 1.2 1 0 0 1 1 1 0 Daxx Family EF-hand_6 PF13405.1 ESL09524.1 - 2e-07 30.3 0.3 0.0034 17.1 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESL09524.1 - 4.3e-06 26.7 0.1 0.0025 17.9 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL09524.1 - 7.6e-05 21.7 0.5 0.023 13.9 0.0 3.6 4 0 0 4 4 4 1 EF hand EF-hand_9 PF14658.1 ESL09524.1 - 0.0076 16.1 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 ESL09524.1 - 0.02 14.4 0.2 3.3 7.3 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain pair Metallophos PF00149.23 ESL09525.1 - 3.7e-41 140.7 0.4 5.2e-41 140.2 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_63 PF03200.11 ESL09526.1 - 2.1e-20 72.2 0.0 2.8e-20 71.8 0.0 1.0 1 0 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Peptidase_S51 PF03575.12 ESL09527.1 - 4.3e-21 75.2 0.0 2.4e-19 69.5 0.0 2.1 1 1 0 1 1 1 1 Peptidase family S51 DUF3650 PF12368.3 ESL09528.1 - 0.37 10.3 3.0 1.1 8.7 0.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3650) DEAD PF00270.24 ESL09529.1 - 1.4e-36 125.4 0.0 6.8e-36 123.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL09529.1 - 5.8e-26 90.1 0.0 5.8e-26 90.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Med15 PF09606.5 ESL09529.1 - 1.1 7.3 24.0 1.6 6.8 16.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Methyltransf_18 PF12847.2 ESL09530.1 - 0.00024 21.6 0.0 0.00047 20.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.12 ESL09530.1 - 0.16 10.8 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase CTDII PF01556.13 ESL09532.1 - 8.7e-19 67.2 1.5 8.3e-09 35.2 0.0 4.8 3 1 2 5 5 5 3 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESL09532.1 - 1.1e-06 28.5 15.8 1.1e-06 28.5 11.0 2.2 2 0 0 2 2 2 1 DnaJ central domain DnaJ PF00226.26 ESL09532.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 DnaJ domain Tox-HNH-HHH PF15637.1 ESL09532.1 - 0.12 12.1 0.1 0.28 10.9 0.1 1.6 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Herpes_LMP1 PF05297.6 ESL09532.1 - 8.1 5.2 6.1 12 4.7 4.2 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Voltage_CLC PF00654.15 ESL09533.1 - 1.1e-78 264.7 33.2 1.4e-78 264.4 23.0 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.23 ESL09533.1 - 3.4e-12 45.9 0.3 1.1e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 CBS domain TPR_11 PF13414.1 ESL09534.1 - 1.1e-13 50.5 12.5 2.4e-09 36.7 0.1 4.9 4 1 1 5 5 5 3 TPR repeat TPR_2 PF07719.12 ESL09534.1 - 4.8e-10 38.5 8.5 0.015 15.1 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESL09534.1 - 5.8e-09 35.4 2.1 0.00016 21.6 0.2 4.7 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09534.1 - 7.6e-09 34.8 2.2 0.26 10.9 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09534.1 - 5.8e-07 29.5 16.7 0.17 12.6 0.0 6.8 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09534.1 - 3.1e-05 23.4 0.1 7 6.6 0.0 5.0 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09534.1 - 0.00026 21.5 6.7 0.038 14.6 0.1 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL09534.1 - 0.003 17.4 13.4 0.61 10.0 0.0 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL09534.1 - 0.003 17.8 5.6 0.27 11.6 0.0 3.8 3 1 1 4 4 3 1 Tetratricopeptide repeat Clathrin PF00637.15 ESL09534.1 - 0.078 12.5 1.9 0.22 11.1 0.3 2.4 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_7 PF13176.1 ESL09534.1 - 4.2 7.4 11.8 13 5.8 0.0 5.1 6 1 0 6 6 6 0 Tetratricopeptide repeat FAST_1 PF06743.10 ESL09535.1 - 1.2e-08 34.5 0.1 0.013 15.1 0.0 5.1 4 2 1 5 5 5 4 FAST kinase-like protein, subdomain 1 DUF3566 PF12089.3 ESL09536.1 - 0.071 13.1 2.8 0.66 9.9 0.0 2.9 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) Mito_carr PF00153.22 ESL09537.1 - 5.7e-49 163.7 5.2 2e-18 65.8 0.0 3.4 2 1 0 3 3 3 3 Mitochondrial carrier protein Tenui_PVC2 PF06656.6 ESL09538.1 - 0.21 9.3 0.1 0.26 9.0 0.0 1.1 1 0 0 1 1 1 0 Tenuivirus PVC2 protein Lipase_3 PF01764.20 ESL09539.1 - 2.8e-13 49.6 0.0 5.5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) FYVE PF01363.16 ESL09539.1 - 0.0021 17.8 23.5 0.0021 17.8 16.3 3.1 2 1 0 2 2 2 1 FYVE zinc finger Abhydrolase_5 PF12695.2 ESL09539.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL09539.1 - 0.025 14.4 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.15 ESL09539.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 ESL09539.1 - 0.21 11.1 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein DZR PF12773.2 ESL09539.1 - 3.3 7.5 27.3 8.8 6.2 5.0 3.5 2 1 1 3 3 3 0 Double zinc ribbon Apolipoprotein PF01442.13 ESL09540.1 - 1.3e-07 31.2 36.4 0.00011 21.7 11.1 2.8 1 1 2 3 3 3 3 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 ESL09540.1 - 2.2e-06 27.5 26.3 0.23 11.2 0.5 4.9 1 1 3 4 4 4 3 Baculovirus polyhedron envelope protein, PEP, C terminus Dynamin_M PF01031.15 ESL09540.1 - 0.00052 18.8 3.4 0.00052 18.8 2.4 2.4 1 1 1 2 2 2 1 Dynamin central region Fib_alpha PF08702.5 ESL09540.1 - 0.033 14.3 1.3 0.033 14.3 0.9 4.6 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family ApoLp-III PF07464.6 ESL09540.1 - 0.054 13.5 26.9 0.062 13.3 3.3 4.2 1 1 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Prominin PF05478.6 ESL09540.1 - 0.071 10.6 29.6 0.0019 15.8 13.0 2.1 1 1 0 2 2 2 0 Prominin Spore_GerAC PF05504.6 ESL09540.1 - 0.13 11.9 2.4 0.7 9.6 0.0 3.1 2 1 1 3 3 3 0 Spore germination B3/ GerAC like, C-terminal YojJ PF10372.4 ESL09540.1 - 0.17 11.7 5.2 27 4.7 0.1 4.0 4 0 0 4 4 4 0 Bacterial membrane-spanning protein N-terminus DNA_pol_B_palm PF14792.1 ESL09540.1 - 0.26 11.3 2.1 1.4 8.9 0.0 3.1 2 1 1 3 3 3 0 DNA polymerase beta palm DUF1664 PF07889.7 ESL09540.1 - 0.35 10.6 23.3 0.87 9.3 2.6 4.8 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) Peptidase_A3 PF02160.10 ESL09540.1 - 1.1 8.8 4.8 0.99 8.9 1.8 2.1 1 1 1 2 2 2 0 Cauliflower mosaic virus peptidase (A3) ING PF12998.2 ESL09540.1 - 1.4 9.2 23.3 2.5 8.4 2.8 5.2 1 1 3 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding Occludin_ELL PF07303.8 ESL09540.1 - 2 9.1 13.8 1.7 9.4 0.3 4.4 2 2 2 4 4 4 0 Occludin homology domain DUF2316 PF10078.4 ESL09540.1 - 2.8 7.9 13.9 0.09 12.7 1.0 3.8 4 2 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2316) YniB PF14002.1 ESL09540.1 - 3.5 7.0 5.1 1.3 8.4 0.1 2.6 3 0 0 3 3 3 0 YniB-like protein DUF842 PF05811.8 ESL09540.1 - 3.9 6.9 10.3 6.5 6.2 0.3 3.0 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF842) DUF1451 PF07295.6 ESL09540.1 - 4.7 6.9 21.0 0.96 9.2 2.0 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1451) Skp1 PF01466.14 ESL09541.1 - 0.089 12.8 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 Skp1 family, dimerisation domain F-box PF00646.28 ESL09542.1 - 0.00084 18.9 0.5 0.0053 16.3 0.0 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 ESL09542.1 - 0.0046 16.6 0.3 0.0046 16.6 0.2 2.9 3 0 0 3 3 3 1 F-box-like TRAP_beta PF05753.9 ESL09543.1 - 1.3e-27 96.0 0.5 2e-27 95.5 0.4 1.2 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) CARDB PF07705.6 ESL09543.1 - 1e-05 25.5 0.1 1.6e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 CARDB DUF11 PF01345.13 ESL09543.1 - 2.2e-05 24.4 1.4 2.2e-05 24.4 1.0 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF11 NPCBM_assoc PF10633.4 ESL09543.1 - 0.099 12.7 0.6 0.33 11.0 0.4 1.8 1 1 0 1 1 1 0 NPCBM-associated, NEW3 domain of alpha-galactosidase A2M PF00207.17 ESL09543.1 - 0.18 11.4 0.9 0.62 9.6 0.2 2.1 2 1 0 2 2 2 0 Alpha-2-macroglobulin family DUF1664 PF07889.7 ESL09545.1 - 0.006 16.3 3.0 0.94 9.2 1.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) IFT57 PF10498.4 ESL09545.1 - 0.029 13.1 7.4 1.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 ApoO PF09769.4 ESL09545.1 - 0.054 13.1 0.6 0.13 11.9 0.4 1.6 1 0 0 1 1 1 0 Apolipoprotein O Reo_sigmaC PF04582.7 ESL09545.1 - 0.34 10.0 2.1 0.97 8.5 0.9 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein HalX PF08663.5 ESL09545.1 - 0.47 10.4 9.5 1.1 9.3 2.8 2.9 2 1 0 2 2 2 0 HalX domain AAA_13 PF13166.1 ESL09545.1 - 0.56 8.6 4.2 0.88 7.9 2.9 1.3 1 0 0 1 1 1 0 AAA domain COG5 PF10392.4 ESL09545.1 - 1 9.3 9.6 1.2 9.0 2.8 2.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Prefoldin_2 PF01920.15 ESL09545.1 - 1.1 9.0 10.4 26 4.6 4.4 2.8 1 1 1 2 2 2 0 Prefoldin subunit Spc7 PF08317.6 ESL09545.1 - 1.6 7.2 10.5 1.3 7.6 5.7 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.5 ESL09545.1 - 2 8.5 6.3 3.8 7.6 4.0 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TMPIT PF07851.8 ESL09545.1 - 2.2 7.2 3.8 14 4.6 0.0 2.1 2 0 0 2 2 2 0 TMPIT-like protein Cluap1 PF10234.4 ESL09545.1 - 7.5 5.6 13.8 29 3.7 9.2 2.0 1 1 0 1 1 1 0 Clusterin-associated protein-1 AAA PF00004.24 ESL09546.1 - 1.8e-14 54.0 0.0 4e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 ESL09546.1 - 1.9e-11 43.7 0.0 3.9e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESL09546.1 - 2.8e-10 40.0 0.0 4.8e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 ESL09546.1 - 1.3e-08 34.0 0.0 5.6e-06 25.3 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 ESL09546.1 - 1.3e-07 30.9 0.0 4.8e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESL09546.1 - 1.2e-06 28.7 0.0 4.2e-06 26.9 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESL09546.1 - 1.3e-06 28.5 0.7 0.00029 20.8 0.0 3.1 1 1 1 3 3 3 1 AAA ATPase domain AAA_19 PF13245.1 ESL09546.1 - 2.4e-05 24.0 0.1 5.8e-05 22.7 0.0 1.7 2 0 0 2 2 1 1 Part of AAA domain AAA_11 PF13086.1 ESL09546.1 - 7.6e-05 22.3 0.0 0.00029 20.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.4 ESL09546.1 - 0.00037 19.5 0.0 0.00072 18.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 ESL09546.1 - 0.0028 17.2 0.0 0.0046 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 ESL09546.1 - 0.0041 16.6 0.1 0.14 11.6 0.0 2.3 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_14 PF13173.1 ESL09546.1 - 0.0048 16.8 0.0 0.0097 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09546.1 - 0.0084 16.9 0.0 0.018 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESL09546.1 - 0.0089 15.4 0.2 0.039 13.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESL09546.1 - 0.0097 15.0 0.0 0.021 13.9 0.0 1.8 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESL09546.1 - 0.01 15.6 0.0 0.03 14.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.1 ESL09546.1 - 0.012 15.6 0.0 0.025 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESL09546.1 - 0.015 14.7 0.0 0.46 9.8 0.0 2.4 3 0 0 3 3 3 0 AAA-like domain AAA_24 PF13479.1 ESL09546.1 - 0.024 14.2 0.0 0.047 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 ESL09546.1 - 0.025 14.4 0.0 0.15 11.8 0.0 2.0 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.9 ESL09546.1 - 0.026 14.2 0.0 0.061 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESL09546.1 - 0.038 13.5 0.0 0.22 11.1 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 ESL09546.1 - 0.058 12.3 0.0 0.42 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_32 PF13654.1 ESL09546.1 - 0.073 11.7 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL09546.1 - 0.081 13.2 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESL09546.1 - 0.1 12.9 0.0 0.18 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain PEPCK_ATP PF01293.15 ESL09546.1 - 0.2 10.1 0.0 0.28 9.6 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase DUF3347 PF11827.3 ESL09547.1 - 0.088 12.7 6.7 0.19 11.7 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) PQQ_2 PF13360.1 ESL09548.1 - 0.0071 15.8 0.0 0.12 11.8 0.0 2.5 2 1 0 2 2 2 1 PQQ-like domain UPF0220 PF05255.6 ESL09549.1 - 8.3e-16 57.6 6.2 1.8e-15 56.5 4.3 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0220) Nucleos_tra2_C PF07662.8 ESL09549.1 - 0.0016 17.9 5.2 0.0022 17.5 3.6 1.2 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus DUF4499 PF14934.1 ESL09549.1 - 0.0078 16.1 2.1 0.011 15.5 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) NrfD PF03916.9 ESL09549.1 - 0.044 13.1 7.7 0.054 12.9 5.4 1.1 1 0 0 1 1 1 0 Polysulphide reductase, NrfD AgrB PF04647.10 ESL09549.1 - 0.076 12.0 2.1 0.099 11.6 1.4 1.3 1 0 0 1 1 1 0 Accessory gene regulator B ABC2_membrane_5 PF13346.1 ESL09549.1 - 0.083 12.1 5.2 0.097 11.9 3.6 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Bax1-I PF01027.15 ESL09549.1 - 0.13 11.8 8.5 0.17 11.4 5.9 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.6 ESL09549.1 - 0.22 11.1 8.2 0.27 10.8 5.0 1.5 1 1 0 1 1 1 0 7TM diverse intracellular signalling NADH-u_ox-rdase PF10785.4 ESL09549.1 - 0.26 11.5 1.7 0.29 11.4 0.1 1.8 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Cytochrom_B_C PF00032.12 ESL09549.1 - 1.1 9.5 5.0 0.82 9.9 2.0 1.8 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD MARVEL PF01284.18 ESL09549.1 - 3.5 7.4 10.7 29 4.4 7.4 2.1 1 1 0 1 1 1 0 Membrane-associating domain DUF2721 PF11026.3 ESL09549.1 - 8.1 6.0 10.9 2.3 7.8 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) DUF1218 PF06749.7 ESL09549.1 - 9.5 6.7 9.3 1.4 9.4 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) Zip PF02535.17 ESL09549.1 - 9.9 5.0 8.6 2 7.3 2.8 1.6 1 1 0 1 1 1 0 ZIP Zinc transporter FGGY_C PF02782.11 ESL09550.1 - 6.1e-39 133.6 0.0 9.4e-39 133.0 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 ESL09550.1 - 3.9e-09 36.1 0.0 1.1e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 ESL09550.1 - 0.0069 15.7 0.2 0.025 13.8 0.0 1.9 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family SopD PF11047.3 ESL09551.1 - 0.15 10.9 0.1 0.35 9.7 0.0 1.5 1 0 0 1 1 1 0 Salmonella outer protein D Methyltransf_18 PF12847.2 ESL09552.1 - 8.8e-12 45.5 0.0 2.3e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESL09552.1 - 1.5e-10 40.7 0.0 2.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESL09552.1 - 8.4e-07 29.0 0.1 1.8e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL09552.1 - 1.5e-06 27.9 0.0 2.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL09552.1 - 3e-06 26.7 0.0 5.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 ESL09552.1 - 9.8e-06 25.2 0.1 2.5e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.11 ESL09552.1 - 2.1e-05 24.2 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_16 PF10294.4 ESL09552.1 - 3.3e-05 23.4 0.0 5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PRMT5 PF05185.11 ESL09552.1 - 3.5e-05 22.9 0.0 4.6e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Cons_hypoth95 PF03602.10 ESL09552.1 - 0.00011 21.6 0.0 0.00016 21.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.15 ESL09552.1 - 0.00052 19.1 0.0 0.00092 18.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_11 PF08241.7 ESL09552.1 - 0.0034 17.8 0.0 0.0079 16.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL09552.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 ESL09552.1 - 0.024 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 ESL09552.1 - 0.079 13.3 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 ESL09552.1 - 0.079 13.7 0.0 0.24 12.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 ESL09553.1 - 8.4e-06 26.3 0.0 1.3e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL09553.1 - 9.2e-05 22.0 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL09553.1 - 0.0016 18.8 0.0 0.0026 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL09553.1 - 0.019 15.0 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Rad51 PF08423.6 ESL09556.1 - 2e-16 59.6 0.4 5.7e-16 58.1 0.2 1.7 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.1 ESL09556.1 - 4.1e-14 52.4 0.3 7e-14 51.6 0.2 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.10 ESL09556.1 - 3.5e-06 26.1 0.4 0.00081 18.3 0.0 2.1 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain KaiC PF06745.8 ESL09556.1 - 9.5e-06 24.8 0.1 2.6e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.1 ESL09556.1 - 1.6e-05 25.0 0.0 4.4e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESL09556.1 - 5.5e-05 23.3 0.3 0.0023 18.1 0.5 2.9 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) RecA PF00154.16 ESL09556.1 - 0.00071 18.7 0.3 0.0018 17.4 0.1 1.6 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_19 PF13245.1 ESL09556.1 - 0.002 17.8 0.4 0.0062 16.2 0.3 1.9 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 ESL09556.1 - 0.0023 17.5 0.8 0.024 14.3 0.5 2.2 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 ESL09556.1 - 0.028 14.4 0.5 0.077 12.9 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.11 ESL09556.1 - 0.028 13.6 0.3 0.051 12.8 0.2 1.3 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.12 ESL09556.1 - 0.051 12.9 1.1 0.07 12.5 0.2 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.1 ESL09556.1 - 0.1 12.5 0.4 0.53 10.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 ESL09556.1 - 0.17 10.7 0.0 0.34 9.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.8 ESL09556.1 - 0.19 10.4 0.4 0.31 9.7 0.3 1.2 1 0 0 1 1 1 0 TIP49 C-terminus Cornichon PF03311.9 ESL09557.1 - 0.001 19.1 9.9 0.001 19.1 6.9 1.4 1 1 0 1 1 1 1 Cornichon protein DUF3483 PF11982.3 ESL09557.1 - 5.5 6.2 10.2 2.6 7.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) Gp_dh_C PF02800.15 ESL09558.1 - 1.5e-63 212.9 0.1 2.1e-63 212.4 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESL09558.1 - 1.1e-39 135.7 0.0 2.1e-39 134.9 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Varsurf_PPLC PF03490.8 ESL09559.1 - 1.5e-28 98.2 0.4 3.4e-28 97.0 0.3 1.6 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C PI-PLC-X PF00388.14 ESL09559.1 - 1.5e-06 27.6 0.0 2.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain TPT PF03151.11 ESL09560.1 - 1.9e-24 86.0 5.6 1.9e-24 86.0 3.9 2.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESL09560.1 - 9.5e-11 41.8 3.6 9.5e-11 41.8 2.5 2.5 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 ESL09560.1 - 8.1e-08 31.5 22.3 1.5e-07 30.6 15.4 1.4 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 ESL09560.1 - 0.047 13.8 19.6 0.13 12.4 1.8 2.4 3 0 0 3 3 3 0 Multidrug resistance efflux transporter Multi_Drug_Res PF00893.14 ESL09560.1 - 0.07 13.6 0.7 0.07 13.6 0.5 3.1 2 1 1 3 3 3 0 Small Multidrug Resistance protein MobB PF03205.9 ESL09562.1 - 0.013 15.1 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MspA PF09203.6 ESL09562.1 - 0.034 13.5 0.1 0.1 12.0 0.0 1.7 2 0 0 2 2 2 0 MspA Ubie_methyltran PF01209.13 ESL09563.1 - 3.1e-99 330.8 0.0 3.7e-99 330.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 ESL09563.1 - 1.1e-13 51.4 0.0 2.7e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL09563.1 - 1.5e-10 41.2 0.0 3.1e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL09563.1 - 3.2e-10 39.7 0.0 5.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL09563.1 - 1.6e-08 34.9 0.0 3.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL09563.1 - 5.3e-07 29.5 0.0 7.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL09563.1 - 0.00036 21.0 0.0 0.001 19.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESL09563.1 - 0.045 13.3 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Hypothetical methyltransferase LSM PF01423.17 ESL09564.1 - 0.0059 16.1 0.1 0.014 14.9 0.1 1.6 1 1 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESL09564.1 - 0.12 12.3 1.9 0.17 11.8 0.1 2.1 2 1 0 2 2 2 0 Ataxin 2 SM domain Pkinase PF00069.20 ESL09565.1 - 4.1e-47 160.5 0.0 2.5e-37 128.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09565.1 - 2.2e-25 89.2 0.4 3.5e-17 62.3 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESL09565.1 - 0.2 10.3 0.5 0.32 9.7 0.3 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase eIF-5a PF01287.15 ESL09566.1 - 1.6e-27 95.2 0.1 2e-27 94.9 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Hist_deacetyl PF00850.14 ESL09567.1 - 4.5e-58 196.9 0.0 6.7e-58 196.4 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DUF2201_N PF13203.1 ESL09567.1 - 0.29 10.2 7.1 0.43 9.6 4.9 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain Spore_coat_CotO PF14153.1 ESL09567.1 - 7 6.0 29.8 10 5.4 20.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DDHD PF02862.12 ESL09567.1 - 7.7 6.2 11.8 11 5.6 8.2 1.3 1 0 0 1 1 1 0 DDHD domain Vps55 PF04133.9 ESL09569.1 - 1.5e-26 92.4 7.2 1.7e-26 92.2 5.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4173 PF13777.1 ESL09569.1 - 0.017 14.3 2.5 0.029 13.6 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) PIG-F PF06699.6 ESL09569.1 - 0.044 13.7 1.8 0.063 13.2 1.3 1.3 1 1 0 1 1 1 0 GPI biosynthesis protein family Pig-F Bax1-I PF01027.15 ESL09569.1 - 0.38 10.3 9.8 0.48 9.9 6.8 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 OPT PF03169.10 ESL09569.1 - 0.61 8.4 6.5 0.7 8.2 4.3 1.2 1 1 0 1 1 1 0 OPT oligopeptide transporter protein Trep_Strep PF09605.5 ESL09569.1 - 4.4 6.9 8.3 3.4 7.2 4.8 1.5 1 1 1 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) PrgI PF12666.2 ESL09569.1 - 9.4 6.4 8.9 6.5 6.9 3.3 2.1 2 0 0 2 2 2 0 PrgI family protein Peptidase_S9 PF00326.16 ESL09570.1 - 6.8e-35 120.2 0.0 1.2e-34 119.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.16 ESL09570.1 - 2.8e-23 82.0 0.1 5.3e-23 81.1 0.1 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_5 PF12695.2 ESL09570.1 - 5.3e-06 26.2 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL09570.1 - 0.003 17.4 0.0 0.0061 16.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family GRAM PF02893.15 ESL09570.1 - 0.0062 16.0 0.0 0.23 10.9 0.0 2.6 2 0 0 2 2 2 1 GRAM domain Esterase PF00756.15 ESL09570.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Peptidase_S15 PF02129.13 ESL09570.1 - 0.06 12.7 0.0 0.22 10.8 0.0 1.8 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.13 ESL09570.1 - 0.13 11.5 0.1 0.31 10.3 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF3141 PF11339.3 ESL09570.1 - 0.16 10.2 0.1 0.26 9.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) DnaJ PF00226.26 ESL09571.1 - 3.3e-10 39.5 0.1 4.7e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain DUF836 PF05768.9 ESL09571.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.6 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) NOT2_3_5 PF04153.13 ESL09572.1 - 1.9e-23 82.8 1.0 1.9e-23 82.8 0.7 2.6 2 1 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Trypan_PARP PF05887.6 ESL09572.1 - 0.026 14.3 2.2 0.062 13.1 1.5 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Med15 PF09606.5 ESL09572.1 - 0.038 12.2 31.7 0.06 11.5 21.9 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 ESL09572.1 - 0.33 10.8 23.8 0.49 10.2 16.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 ESL09572.1 - 1.1 7.3 38.2 1.5 6.9 26.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PLRV_ORF5 PF01690.12 ESL09572.1 - 1.4 7.9 19.2 2.3 7.2 13.3 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Suf PF05843.9 ESL09572.1 - 1.8 8.2 10.9 2.7 7.6 7.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ABC_tran PF00005.22 ESL09574.1 - 6.3e-44 149.6 0.0 8.1e-22 77.9 0.0 3.0 3 1 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 ESL09574.1 - 1.4e-20 72.9 3.5 1.4e-20 72.9 2.4 3.2 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.1 ESL09574.1 - 1.8e-20 74.0 0.3 1.5e-06 28.4 1.3 4.1 3 1 0 3 3 3 3 AAA domain AAA_17 PF13207.1 ESL09574.1 - 2e-08 35.0 0.3 0.0023 18.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.14 ESL09574.1 - 2.2e-08 33.6 3.6 0.05 12.8 0.5 4.0 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 ESL09574.1 - 9.1e-07 29.2 0.1 0.01 16.1 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 ESL09574.1 - 2.5e-06 26.9 0.1 0.06 12.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.1 ESL09574.1 - 3.9e-06 26.9 0.0 0.083 12.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESL09574.1 - 4.3e-06 26.9 0.0 0.0064 16.6 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ESL09574.1 - 8.8e-06 25.8 0.0 0.014 15.6 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.1 ESL09574.1 - 9.9e-06 25.4 0.0 1.1 9.2 0.0 3.5 3 0 0 3 3 3 2 AAA domain Miro PF08477.8 ESL09574.1 - 2.2e-05 24.9 0.0 0.033 14.7 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein NACHT PF05729.7 ESL09574.1 - 5.9e-05 22.7 0.2 0.13 11.9 0.0 3.0 3 0 0 3 3 3 1 NACHT domain DUF258 PF03193.11 ESL09574.1 - 7.6e-05 21.9 0.0 0.38 9.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESL09574.1 - 8.6e-05 22.6 0.1 0.25 11.4 0.1 3.2 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESL09574.1 - 0.00016 21.1 0.0 0.53 9.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain PduV-EutP PF10662.4 ESL09574.1 - 0.00024 20.6 0.0 0.26 10.7 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.1 ESL09574.1 - 0.00028 20.7 1.9 0.11 12.4 0.0 3.1 3 1 0 3 3 2 1 AAA domain AAA_16 PF13191.1 ESL09574.1 - 0.00031 20.7 2.2 0.071 13.0 0.0 3.3 3 1 0 3 3 2 1 AAA ATPase domain AAA_15 PF13175.1 ESL09574.1 - 0.00033 19.8 0.4 0.44 9.5 0.0 3.7 4 1 0 4 4 4 1 AAA ATPase domain Arch_ATPase PF01637.13 ESL09574.1 - 0.00042 20.0 0.1 0.16 11.5 0.0 2.6 3 0 0 3 3 2 1 Archaeal ATPase AAA_5 PF07728.9 ESL09574.1 - 0.00045 19.9 0.3 0.049 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) MobB PF03205.9 ESL09574.1 - 0.00063 19.4 0.2 0.072 12.7 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_13 PF13166.1 ESL09574.1 - 0.00075 18.0 2.7 0.57 8.5 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_10 PF12846.2 ESL09574.1 - 0.00089 18.7 0.2 0.4 10.0 0.0 3.0 3 0 0 3 3 3 1 AAA-like domain UPF0079 PF02367.12 ESL09574.1 - 0.001 18.6 0.2 0.013 15.1 0.0 2.5 2 1 1 3 3 2 1 Uncharacterised P-loop hydrolase UPF0079 SbcCD_C PF13558.1 ESL09574.1 - 0.0026 17.6 0.1 0.44 10.5 0.0 3.1 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.7 ESL09574.1 - 0.003 16.6 0.1 0.12 11.4 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.18 ESL09574.1 - 0.0061 16.4 0.1 5 7.1 0.0 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_19 PF13245.1 ESL09574.1 - 0.0081 15.8 0.0 0.097 12.4 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain ATP-synt_ab PF00006.20 ESL09574.1 - 0.012 15.0 0.0 1.9 7.9 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.16 ESL09574.1 - 0.013 14.6 0.0 2.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF87 PF01935.12 ESL09574.1 - 0.016 15.0 0.0 3.9 7.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_23 PF13476.1 ESL09574.1 - 0.017 15.4 14.7 0.067 13.5 0.0 3.5 3 1 0 3 3 2 0 AAA domain NB-ARC PF00931.17 ESL09574.1 - 0.017 13.9 0.0 5.1 5.8 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.14 ESL09574.1 - 0.021 14.2 0.4 2.3 7.6 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.15 ESL09574.1 - 0.027 13.1 0.0 3.4 6.2 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit ArgK PF03308.11 ESL09574.1 - 0.032 13.0 1.2 0.97 8.1 0.0 2.6 3 0 0 3 3 3 0 ArgK protein SRP54 PF00448.17 ESL09574.1 - 0.036 13.5 0.3 0.62 9.4 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.10 ESL09574.1 - 0.038 13.6 0.1 0.79 9.4 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.1 ESL09574.1 - 0.038 13.5 0.0 1.2 8.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain Arf PF00025.16 ESL09574.1 - 0.057 12.6 0.0 1.1 8.4 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family IstB_IS21 PF01695.12 ESL09574.1 - 0.066 12.6 0.0 2 7.7 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activ_2 PF14532.1 ESL09574.1 - 0.074 13.1 0.0 0.75 9.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain RuvB_N PF05496.7 ESL09574.1 - 0.099 11.6 0.0 0.33 9.9 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Dynamin_N PF00350.18 ESL09574.1 - 0.21 11.4 3.7 2.6 7.8 0.1 3.8 4 1 0 4 4 3 0 Dynamin family TPT PF03151.11 ESL09576.1 - 3.2e-24 85.3 5.6 3.2e-24 85.3 3.9 2.7 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESL09576.1 - 1.5e-11 44.4 29.7 1.6e-10 41.0 2.5 2.4 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 ESL09576.1 - 3.5e-08 32.7 31.8 5.7e-08 32.0 22.1 1.3 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 ESL09576.1 - 0.61 10.3 25.7 0.29 11.3 2.8 3.0 2 1 1 3 3 3 0 Multidrug resistance efflux transporter DUF2238 PF09997.4 ESL09576.1 - 0.78 9.1 11.9 0.097 12.0 4.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2238) AAA_23 PF13476.1 ESL09577.1 - 1.2e-16 61.6 14.4 1.2e-16 61.6 10.0 7.6 2 2 0 2 2 1 1 AAA domain SMC_N PF02463.14 ESL09577.1 - 3.5e-12 46.0 10.6 1.1e-05 24.7 0.0 2.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 ESL09577.1 - 2.3e-11 43.4 0.1 8.7e-11 41.6 0.1 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.1 ESL09577.1 - 4.1e-09 36.8 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 ESL09577.1 - 6.2e-08 32.1 3.6 0.00032 19.8 0.0 3.2 3 1 0 3 3 3 2 AAA ATPase domain DUF948 PF06103.6 ESL09577.1 - 0.00018 21.3 0.8 0.00018 21.3 0.5 5.9 5 2 2 7 7 6 1 Bacterial protein of unknown function (DUF948) AAA_29 PF13555.1 ESL09577.1 - 0.0005 19.5 0.0 0.0013 18.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESL09577.1 - 0.002 18.3 0.0 0.002 18.3 0.0 6.1 5 2 0 5 5 4 2 ABC transporter Reo_sigmaC PF04582.7 ESL09577.1 - 0.0089 15.2 18.5 0.025 13.7 1.1 5.4 3 2 0 5 5 5 2 Reovirus sigma C capsid protein Rad50_zn_hook PF04423.9 ESL09577.1 - 0.018 14.4 0.1 0.018 14.4 0.0 4.5 4 1 0 4 4 3 0 Rad50 zinc hook motif MobB PF03205.9 ESL09577.1 - 0.045 13.4 0.1 0.37 10.4 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ESL09577.1 - 0.049 13.3 0.0 0.21 11.3 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain Baculo_IE-1 PF05290.6 ESL09577.1 - 0.069 12.8 0.7 0.75 9.5 0.0 2.9 3 0 0 3 3 3 0 Baculovirus immediate-early protein (IE-0) MMR_HSR1 PF01926.18 ESL09577.1 - 0.22 11.5 1.5 1.5 8.7 0.0 3.1 3 0 0 3 3 2 0 50S ribosome-binding GTPase UPF0184 PF03670.8 ESL09577.1 - 0.44 10.7 9.9 2.7 8.2 0.7 4.9 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0184) DUF3138 PF11336.3 ESL09577.1 - 0.86 7.7 5.4 0.17 10.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) AAA_22 PF13401.1 ESL09577.1 - 1.1 9.3 6.5 0.46 10.6 0.0 3.8 4 0 0 4 4 3 0 AAA domain Filo_VP35 PF02097.10 ESL09577.1 - 2.2 7.4 11.4 0.48 9.5 0.3 3.6 3 0 0 3 3 3 0 Filoviridae VP35 Frankia_peptide PF14407.1 ESL09578.1 - 0.13 12.0 0.1 10 5.9 0.1 2.2 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. IBR PF01485.16 ESL09579.1 - 6.5e-14 51.5 25.1 1.5e-08 34.3 3.2 4.4 3 1 1 4 4 4 2 IBR domain zf-RING_2 PF13639.1 ESL09579.1 - 0.00034 20.3 11.1 0.00034 20.3 7.7 4.0 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.1 ESL09579.1 - 0.011 15.4 10.8 0.011 15.4 7.5 3.9 3 1 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESL09579.1 - 0.018 15.0 11.3 0.018 15.0 7.8 4.4 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) SLAC1 PF03595.12 ESL09580.1 - 0.022 13.4 0.0 0.024 13.2 0.0 1.0 1 0 0 1 1 1 0 Voltage-dependent anion channel DUF4381 PF14316.1 ESL09580.1 - 0.25 11.4 1.5 0.36 10.9 1.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) DUF4131 PF13567.1 ESL09580.1 - 1.5 8.1 4.3 2.8 7.3 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PHO4 PF01384.15 ESL09581.1 - 0.041 12.5 3.7 0.058 12.0 2.6 1.2 1 0 0 1 1 1 0 Phosphate transporter family Clc-like PF07062.7 ESL09581.1 - 0.074 12.2 2.5 0.12 11.6 1.7 1.3 1 0 0 1 1 1 0 Clc-like Amastin PF07344.6 ESL09581.1 - 0.14 11.8 8.0 2 7.9 2.6 2.1 1 1 1 2 2 2 0 Amastin surface glycoprotein DUF1700 PF08006.6 ESL09581.1 - 0.6 9.3 5.6 0.46 9.7 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) DUF4586 PF15239.1 ESL09582.1 - 1.1e-34 120.3 6.2 1.5e-34 119.9 4.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) PARP_regulatory PF01358.13 ESL09583.1 - 8.1e-25 87.0 0.0 1.3e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Poly A polymerase regulatory subunit DUF879 PF05947.7 ESL09584.1 - 0.016 13.6 0.0 0.018 13.4 0.0 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF879) DER1 PF04511.10 ESL09587.1 - 3.2e-33 114.8 15.4 3.9e-33 114.6 10.7 1.0 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.12 ESL09587.1 - 0.018 14.5 0.9 0.032 13.8 0.6 1.5 1 0 0 1 1 1 0 Oleosin Serpentine_r_xa PF03383.10 ESL09587.1 - 0.099 12.3 4.2 0.16 11.7 2.6 1.8 1 1 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa DUF1206 PF06724.6 ESL09588.1 - 0.5 10.1 3.9 7.8 6.3 0.1 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1206) WD40 PF00400.27 ESL09589.1 - 8.8e-14 50.7 9.5 0.0071 16.1 0.1 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat TFIIIC_delta PF12657.2 ESL09589.1 - 0.011 15.4 0.0 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term F-box-like PF12937.2 ESL09590.1 - 0.0055 16.4 0.3 0.022 14.4 0.2 2.2 1 0 0 1 1 1 1 F-box-like GTSE1_N PF15259.1 ESL09590.1 - 0.021 14.7 0.9 0.021 14.7 0.6 2.2 3 0 0 3 3 3 0 G-2 and S-phase expressed 1 Sigma70_ner PF04546.8 ESL09590.1 - 2.1 7.8 10.7 5.8 6.4 7.4 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.7 ESL09590.1 - 3.8 5.2 18.5 5.4 4.8 12.8 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.5 ESL09590.1 - 7.7 6.8 16.0 15 5.8 9.2 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AAA PF00004.24 ESL09591.1 - 2.1e-39 134.7 0.0 1e-38 132.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESL09591.1 - 2.9e-26 91.1 0.1 9.1e-26 89.5 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 ESL09591.1 - 1.1e-20 73.2 1.2 1.1e-20 73.2 0.9 2.1 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 ESL09591.1 - 2e-06 28.5 0.0 2.4e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESL09591.1 - 3.9e-06 27.0 0.3 0.00018 21.6 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESL09591.1 - 2.3e-05 24.3 0.3 6.9e-05 22.8 0.0 2.0 3 0 0 3 3 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 ESL09591.1 - 4.2e-05 23.2 0.0 0.00022 20.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESL09591.1 - 7.2e-05 22.6 0.0 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESL09591.1 - 0.00016 21.1 0.8 0.19 11.1 0.1 2.4 1 1 1 2 2 2 2 AAA domain IstB_IS21 PF01695.12 ESL09591.1 - 0.00027 20.4 0.0 0.00053 19.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESL09591.1 - 0.00049 19.9 0.0 0.0021 17.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESL09591.1 - 0.0006 18.9 0.0 0.0013 17.8 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL09591.1 - 0.00064 19.7 0.0 0.0029 17.5 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 ESL09591.1 - 0.003 16.7 0.0 0.011 14.8 0.0 2.0 1 1 0 1 1 1 1 Zeta toxin DUF815 PF05673.8 ESL09591.1 - 0.003 16.5 0.0 0.0054 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.8 ESL09591.1 - 0.0081 14.9 0.4 0.016 13.9 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus Mg_chelatase PF01078.16 ESL09591.1 - 0.0087 15.2 0.0 0.023 13.8 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI USP8_dimer PF08969.6 ESL09591.1 - 0.01 15.7 1.9 0.032 14.1 1.3 1.9 1 0 0 1 1 1 0 USP8 dimerisation domain RNA_helicase PF00910.17 ESL09591.1 - 0.011 15.9 0.0 0.032 14.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 ESL09591.1 - 0.02 14.4 1.3 0.11 12.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 ESL09591.1 - 0.034 13.6 0.0 0.15 11.5 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.1 ESL09591.1 - 0.042 13.6 0.1 0.28 10.9 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain Viral_helicase1 PF01443.13 ESL09591.1 - 0.042 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PPV_E1_C PF00519.12 ESL09591.1 - 0.045 12.3 0.0 0.077 11.5 0.0 1.4 1 1 0 1 1 1 0 Papillomavirus helicase ABC_tran PF00005.22 ESL09591.1 - 0.057 13.7 0.2 3.1 8.1 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.1 ESL09591.1 - 0.065 13.1 0.0 0.24 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESL09591.1 - 0.066 12.9 3.5 2.3 7.8 0.0 3.5 2 2 1 3 3 3 0 Archaeal ATPase AAA_10 PF12846.2 ESL09591.1 - 0.18 11.2 1.2 1 8.7 0.0 2.6 4 0 0 4 4 3 0 AAA-like domain DnaJ PF00226.26 ESL09592.1 - 8.8e-12 44.5 0.1 1.9e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Abhydrolase_6 PF12697.2 ESL09593.1 - 6.5e-20 71.9 0.1 1.1e-19 71.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESL09593.1 - 1.1e-19 70.1 0.1 2.2e-19 69.0 0.1 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 ESL09593.1 - 2.8e-17 62.8 0.0 1.2e-16 60.8 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL09593.1 - 5.4e-10 39.2 0.0 5.3e-09 35.9 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESL09593.1 - 3.6e-05 23.0 0.0 0.007 15.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.15 ESL09593.1 - 0.00018 21.0 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 ESL09593.1 - 0.0056 16.1 0.0 0.36 10.2 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.13 ESL09593.1 - 0.0061 15.8 0.1 0.074 12.3 0.0 2.3 2 1 0 2 2 2 1 Dienelactone hydrolase family PGAP1 PF07819.8 ESL09593.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2305 PF10230.4 ESL09593.1 - 0.023 14.0 0.0 0.98 8.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Peptidase_S15 PF02129.13 ESL09593.1 - 0.035 13.5 0.0 0.11 11.8 0.0 1.8 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.15 ESL09593.1 - 0.076 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 ESL09593.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold PhoPQ_related PF10142.4 ESL09593.1 - 0.13 10.7 0.0 0.45 8.9 0.0 1.8 3 0 0 3 3 3 0 PhoPQ-activated pathogenicity-related protein Adaptin_N PF01602.15 ESL09594.1 - 5.9e-48 163.4 6.8 7.5e-48 163.1 4.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESL09594.1 - 9.7e-12 45.0 5.5 2.2e-05 24.6 1.2 4.2 2 1 2 4 4 4 2 HEAT repeats HEAT PF02985.17 ESL09594.1 - 4.1e-06 26.4 3.8 0.17 12.0 0.0 4.5 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.2 ESL09594.1 - 0.0016 18.3 8.1 0.41 10.4 0.6 3.7 2 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESL09594.1 - 0.0029 18.0 3.2 0.7 10.4 0.0 4.5 4 2 2 6 6 6 1 HEAT-like repeat U3snoRNP10 PF12397.3 ESL09594.1 - 0.018 15.0 5.8 4.5 7.2 0.0 3.9 3 1 1 4 4 4 0 U3 small nucleolar RNA-associated protein 10 Ipi1_N PF12333.3 ESL09594.1 - 0.03 14.2 1.2 5.3 7.0 0.0 3.0 2 1 1 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation adh_short PF00106.20 ESL09595.1 - 3.9e-06 26.8 0.0 0.00084 19.2 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 ESL09595.1 - 0.021 14.6 0.0 0.62 9.7 0.0 2.2 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Miro PF08477.8 ESL09597.1 - 0.0075 16.7 0.0 0.031 14.7 0.0 2.1 1 1 0 1 1 1 1 Miro-like protein AAA_14 PF13173.1 ESL09597.1 - 0.062 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_L19e PF01280.15 ESL09597.1 - 0.25 11.1 4.2 0.61 9.8 2.9 1.6 1 0 0 1 1 1 0 Ribosomal protein L19e Nop14 PF04147.7 ESL09599.1 - 3.8 5.2 9.0 5.3 4.8 6.3 1.1 1 0 0 1 1 1 0 Nop14-like family PPR_3 PF13812.1 ESL09600.1 - 2.8e-06 27.1 7.6 4.4 7.8 0.0 6.7 8 0 0 8 8 8 3 Pentatricopeptide repeat domain PPR PF01535.15 ESL09600.1 - 2.8e-05 23.7 7.6 0.21 11.6 0.1 6.2 6 1 1 7 7 7 2 PPR repeat PPR_2 PF13041.1 ESL09600.1 - 6.3e-05 22.8 1.4 3.5 7.6 0.0 5.2 5 1 1 6 6 6 2 PPR repeat family Methyltransf_26 PF13659.1 ESL09602.1 - 1.3e-07 31.6 0.1 4.1e-07 30.0 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL09602.1 - 0.0005 20.6 0.0 0.0011 19.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL09602.1 - 0.0049 16.4 0.0 0.0092 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL09602.1 - 0.0064 16.8 0.1 0.015 15.6 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL09602.1 - 0.0092 16.4 0.0 0.065 13.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESL09602.1 - 0.0094 15.3 0.1 0.02 14.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 ESL09602.1 - 0.014 15.8 0.0 0.037 14.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.6 ESL09602.1 - 0.02 13.5 0.0 0.036 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DnaJ PF00226.26 ESL09605.1 - 2e-21 75.4 0.2 2.9e-21 74.9 0.2 1.2 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.4 ESL09605.1 - 3.5e-08 33.3 10.2 3.5e-08 33.3 7.0 2.0 2 0 0 2 2 2 1 Transmembrane Fragile-X-F protein ATP-synt_C PF00137.16 ESL09605.1 - 0.013 15.4 4.3 0.035 14.0 0.9 2.6 2 0 0 2 2 2 0 ATP synthase subunit C PQQ_2 PF13360.1 ESL09606.1 - 1.8e-16 60.3 1.1 7.4e-08 32.1 0.1 3.0 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.16 ESL09606.1 - 6.7e-06 25.3 0.4 0.078 12.5 0.0 4.2 3 0 0 3 3 3 2 PQQ enzyme repeat WD40 PF00400.27 ESL09608.1 - 4.9e-26 89.6 0.5 4.6e-05 23.1 0.0 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Peptidase_S24 PF00717.18 ESL09609.1 - 4.7e-12 45.3 0.0 9.9e-12 44.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase S24-like AAA_22 PF13401.1 ESL09610.1 - 0.00026 21.1 0.0 0.00051 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL09610.1 - 0.0022 17.9 0.7 0.026 14.5 0.5 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 ESL09610.1 - 0.015 15.2 0.0 0.034 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL09610.1 - 0.026 14.3 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 ESL09610.1 - 0.027 13.7 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B NACHT PF05729.7 ESL09610.1 - 0.039 13.6 0.0 0.083 12.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.1 ESL09610.1 - 0.044 14.6 0.0 0.19 12.5 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESL09610.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ESL09610.1 - 0.11 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 ESL09610.1 - 0.12 11.7 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain eIF-1a PF01176.14 ESL09611.1 - 4.7e-17 61.1 0.2 8.3e-17 60.3 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 GrpB PF04229.9 ESL09611.1 - 0.075 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 GrpB protein Nucleoside_tran PF01733.13 ESL09612.1 - 1.3e-25 90.2 8.1 1.3e-25 90.2 5.6 2.0 2 0 0 2 2 2 1 Nucleoside transporter SH3_3 PF08239.6 ESL09613.1 - 0.00011 22.3 0.5 0.42 10.8 0.0 2.9 3 1 0 3 3 3 2 Bacterial SH3 domain GTP_EFTU PF00009.22 ESL09614.1 - 6.2e-11 42.0 0.0 1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF348 PF03990.9 ESL09614.1 - 0.045 13.3 0.1 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF348) Miro PF08477.8 ESL09614.1 - 0.067 13.7 0.2 0.8 10.2 0.0 2.5 2 1 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 ESL09614.1 - 0.095 12.2 0.2 0.22 11.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 ESL09614.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 ESL09614.1 - 0.16 12.2 0.4 0.3 11.3 0.3 1.4 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.1 ESL09614.1 - 0.17 11.7 1.0 0.75 9.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF1675 PF07897.6 ESL09615.1 - 0.064 13.1 13.1 0.072 12.9 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) eIF3g PF12353.3 ESL09615.1 - 0.26 11.2 7.5 0.34 10.8 5.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Bac_luciferase PF00296.15 ESL09615.1 - 0.39 9.7 4.6 0.46 9.5 3.2 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase Nop25 PF09805.4 ESL09615.1 - 2 8.4 18.7 2.8 8.0 13.0 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) DDRGK PF09756.4 ESL09615.1 - 4.7 6.5 16.4 6.3 6.1 11.4 1.1 1 0 0 1 1 1 0 DDRGK domain Kelch_3 PF13415.1 ESL09616.1 - 6.5e-18 64.3 1.2 6.8e-07 29.2 0.0 3.7 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL09616.1 - 1.7e-10 40.6 0.6 1.7e-06 27.8 0.0 4.4 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.1 ESL09616.1 - 2.5e-09 36.7 2.0 8.9e-06 25.3 0.0 4.2 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESL09616.1 - 4.7e-09 36.0 0.4 0.00011 22.1 0.0 3.9 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 ESL09616.1 - 0.00038 19.9 0.5 0.008 15.7 0.0 3.1 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.10 ESL09616.1 - 0.0042 16.8 2.9 0.68 9.8 0.0 3.5 5 0 0 5 5 5 1 Kelch motif DUF2779 PF11074.3 ESL09617.1 - 3.3e-43 146.8 0.1 6.5e-43 145.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function(DUF2779) ParA PF10609.4 ESL09618.1 - 9.2e-31 105.5 0.1 1.9e-30 104.5 0.1 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESL09618.1 - 1.8e-16 60.1 0.0 2.5e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 ESL09618.1 - 1.8e-07 30.5 0.0 2.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 ESL09618.1 - 0.00015 21.7 0.0 0.00029 20.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09618.1 - 0.00076 20.2 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 ESL09618.1 - 0.00083 18.4 0.2 0.0015 17.6 0.2 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase NB-ARC PF00931.17 ESL09618.1 - 0.0014 17.5 0.8 0.0028 16.5 0.1 1.7 2 0 0 2 2 2 1 NB-ARC domain ArgK PF03308.11 ESL09618.1 - 0.0018 17.1 0.1 0.0027 16.5 0.1 1.2 1 0 0 1 1 1 1 ArgK protein DUF258 PF03193.11 ESL09618.1 - 0.0018 17.4 0.1 0.0037 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 MobB PF03205.9 ESL09618.1 - 0.0038 16.9 0.0 0.007 16.0 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 ESL09618.1 - 0.0048 16.9 0.0 0.009 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Fer4_NifH PF00142.13 ESL09618.1 - 0.005 16.0 0.0 0.017 14.3 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family APS_kinase PF01583.15 ESL09618.1 - 0.0054 16.3 0.0 0.0085 15.7 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_25 PF13481.1 ESL09618.1 - 0.0077 15.6 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL09618.1 - 0.0099 16.1 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain YhjQ PF06564.7 ESL09618.1 - 0.019 14.3 0.7 0.033 13.5 0.1 1.7 2 0 0 2 2 2 0 YhjQ protein zf-C4_ClpX PF06689.8 ESL09618.1 - 0.021 14.3 0.3 0.06 12.8 0.2 1.8 1 0 0 1 1 1 0 ClpX C4-type zinc finger NTPase_1 PF03266.10 ESL09618.1 - 0.028 14.1 0.2 0.059 13.0 0.1 1.5 1 0 0 1 1 1 0 NTPase AAA_26 PF13500.1 ESL09618.1 - 0.031 13.8 0.1 8.2 5.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESL09618.1 - 0.051 13.1 0.1 0.13 11.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 ESL09618.1 - 0.056 13.0 0.5 0.095 12.3 0.4 1.3 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 ESL09618.1 - 0.079 13.1 0.4 0.25 11.5 0.1 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESL09618.1 - 0.12 12.5 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 RNA helicase AAA PF00004.24 ESL09619.1 - 1.5e-41 141.7 0.0 2.4e-41 141.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESL09619.1 - 4.4e-08 32.8 0.0 1.2e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 ESL09619.1 - 1.5e-05 25.1 0.2 0.00046 20.3 0.1 2.6 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.1 ESL09619.1 - 6.7e-05 22.7 0.0 0.00023 21.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESL09619.1 - 0.00015 21.7 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 ESL09619.1 - 0.00016 21.4 0.4 0.0017 18.0 0.3 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 ESL09619.1 - 0.00026 19.8 0.0 0.00041 19.1 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 ESL09619.1 - 0.00057 19.3 0.9 0.21 10.9 0.3 3.0 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.7 ESL09619.1 - 0.00063 18.8 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 ESL09619.1 - 0.00067 19.1 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESL09619.1 - 0.00085 19.2 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL09619.1 - 0.0011 18.9 0.0 0.0026 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 ESL09619.1 - 0.0021 17.8 0.1 0.012 15.3 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain DUF815 PF05673.8 ESL09619.1 - 0.0022 16.9 0.0 0.0039 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 ESL09619.1 - 0.0028 16.8 0.0 0.0057 15.8 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 ESL09619.1 - 0.0031 18.3 0.0 0.008 16.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 ESL09619.1 - 0.0036 16.9 0.0 0.01 15.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial dnaA protein NACHT PF05729.7 ESL09619.1 - 0.0057 16.3 0.1 0.15 11.6 0.0 2.5 1 1 1 2 2 2 1 NACHT domain AAA_30 PF13604.1 ESL09619.1 - 0.0087 15.6 0.1 1.5 8.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 ESL09619.1 - 0.013 15.1 0.0 0.036 13.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.1 ESL09619.1 - 0.015 15.6 0.1 0.062 13.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESL09619.1 - 0.021 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESL09619.1 - 0.026 13.6 0.0 0.068 12.2 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.21 ESL09619.1 - 0.046 13.1 0.1 0.34 10.3 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.11 ESL09619.1 - 0.048 12.8 0.1 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.1 ESL09619.1 - 0.056 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL09619.1 - 0.066 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.1 ESL09619.1 - 0.09 12.8 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain Ribosomal_S25 PF03297.10 ESL09620.1 - 7.2e-39 132.0 3.8 8e-39 131.9 2.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein EAP30 PF04157.11 ESL09620.1 - 0.088 11.9 0.0 6.9 5.7 0.0 2.0 1 1 1 2 2 2 0 EAP30/Vps36 family DUF3516 PF12029.3 ESL09620.1 - 0.11 11.3 0.4 0.11 11.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) Robl_LC7 PF03259.12 ESL09621.1 - 1.1e-22 79.3 0.0 1.3e-22 79.1 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LicD PF04991.8 ESL09622.1 - 3.4e-05 24.0 0.2 0.00075 19.6 0.3 2.2 2 0 0 2 2 2 1 LicD family G-patch PF01585.18 ESL09623.1 - 2.5e-11 43.1 2.5 4e-11 42.4 1.8 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESL09623.1 - 0.00013 21.7 1.3 0.00036 20.3 0.9 1.8 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF4599 PF15371.1 ESL09623.1 - 0.06 13.4 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4599) ADK PF00406.17 ESL09624.1 - 1.9e-52 177.1 0.0 2.2e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 ESL09624.1 - 6.6e-14 51.2 0.0 1.7e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 ESL09624.1 - 1.3e-06 29.2 0.0 2.2e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL09624.1 - 0.00039 20.3 0.0 0.0021 17.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESL09624.1 - 0.028 14.3 0.7 0.69 9.8 0.5 2.4 1 1 0 1 1 1 0 AAA domain SURF6 PF04935.7 ESL09626.1 - 4.1e-09 36.0 13.6 4.1e-09 36.0 9.4 2.4 1 1 1 2 2 2 1 Surfeit locus protein 6 DUF2785 PF10978.3 ESL09626.1 - 0.038 13.4 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) DUF4379 PF14311.1 ESL09628.1 - 1.1e-45 153.2 14.3 2.5e-16 59.2 0.7 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF4379) Zn-ribbon_8 PF09723.5 ESL09628.1 - 0.0031 17.4 0.3 0.0031 17.4 0.2 3.7 3 1 0 3 3 3 1 Zinc ribbon domain zf-MIZ PF02891.15 ESL09628.1 - 0.019 14.4 0.4 0.019 14.4 0.3 4.1 5 0 0 5 5 5 0 MIZ/SP-RING zinc finger zf-CSL PF05207.8 ESL09628.1 - 0.025 14.1 0.2 0.025 14.1 0.2 3.1 4 1 0 4 4 3 0 CSL zinc finger SprT-like PF10263.4 ESL09628.1 - 0.033 13.8 3.6 5.5 6.6 0.1 3.3 3 0 0 3 3 3 0 SprT-like family UPF0547 PF10571.4 ESL09628.1 - 0.036 13.7 24.4 0.11 12.1 0.0 5.3 5 0 0 5 5 5 0 Uncharacterised protein family UPF0547 HypA PF01155.14 ESL09628.1 - 0.12 12.0 12.0 0.61 9.7 0.2 3.4 1 1 2 3 3 3 0 Hydrogenase expression/synthesis hypA family Pox_A28 PF04584.9 ESL09628.1 - 0.13 12.1 0.7 0.35 10.7 0.5 1.7 1 0 0 1 1 1 0 Poxvirus A28 family 7TM_transglut PF14402.1 ESL09628.1 - 0.18 10.7 0.1 0.26 10.1 0.1 1.1 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase OrfB_Zn_ribbon PF07282.6 ESL09628.1 - 0.19 11.3 10.9 8.8 6.0 0.0 4.3 3 2 1 4 4 4 0 Putative transposase DNA-binding domain CpXC PF14353.1 ESL09628.1 - 1.5 8.7 13.2 3.3 7.7 0.1 4.1 3 2 1 4 4 4 0 CpXC protein Gin PF10764.4 ESL09628.1 - 5.7 6.7 7.2 29 4.4 3.2 2.6 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin zf-ribbon_3 PF13248.1 ESL09628.1 - 8 5.8 16.6 0.3 10.3 1.7 4.2 4 1 1 5 5 5 0 zinc-ribbon domain Prenyltrans PF00432.16 ESL09629.1 - 3.8e-21 74.3 24.1 7.4e-07 28.6 0.7 6.6 7 1 0 7 7 7 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESL09629.1 - 2.1e-14 53.8 0.4 9.6e-10 38.8 0.0 3.9 3 1 1 4 4 4 2 Prenyltransferase-like Luteo_P1-P2 PF08467.5 ESL09629.1 - 0.094 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase YozD PF14162.1 ESL09629.1 - 0.17 11.9 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 YozD-like protein zf-C2H2_jaz PF12171.3 ESL09630.1 - 0.011 15.7 0.2 0.028 14.5 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESL09630.1 - 0.028 14.6 0.4 0.063 13.5 0.3 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 ESL09630.1 - 0.04 14.2 0.6 0.092 13.1 0.4 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.1 ESL09630.1 - 0.072 13.3 0.3 0.19 12.0 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain TFIIA PF03153.8 ESL09630.1 - 6.7 6.4 21.4 10 5.9 14.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UQ_con PF00179.21 ESL09631.1 - 3.8e-17 62.0 0.0 3.9e-17 61.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESL09631.1 - 0.0031 17.4 0.0 0.0034 17.2 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESL09631.1 - 0.017 14.7 0.1 0.029 14.0 0.0 1.4 1 1 0 1 1 1 0 UEV domain Pyr_redox PF00070.22 ESL09633.1 - 4.4e-12 46.2 0.0 2.6e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESL09633.1 - 3.8e-07 30.2 0.0 0.018 14.8 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESL09633.1 - 2.1e-05 23.5 0.0 0.025 13.4 0.0 3.1 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_Gly3P_dh_N PF01210.18 ESL09633.1 - 0.00025 20.8 0.0 0.0017 18.1 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DAO PF01266.19 ESL09633.1 - 0.00076 18.4 0.0 0.13 11.1 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESL09633.1 - 0.0012 18.8 0.0 0.022 14.8 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 ESL09633.1 - 0.0013 18.1 0.0 0.087 12.1 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 ESL09633.1 - 0.0044 16.6 0.0 0.28 10.8 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 ESL09633.1 - 0.009 16.2 0.0 6.4 7.0 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.1 ESL09633.1 - 0.013 15.4 0.0 11 6.1 0.0 3.3 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESL09633.1 - 0.04 13.6 0.0 1.9 8.2 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Ldh_1_N PF00056.18 ESL09633.1 - 0.045 13.5 0.1 0.21 11.4 0.0 2.2 3 0 0 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain K_oxygenase PF13434.1 ESL09633.1 - 0.086 11.7 0.0 0.23 10.3 0.0 1.6 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) CDP-OH_P_transf PF01066.16 ESL09634.1 - 1.2e-10 41.6 28.0 3.5e-09 36.8 19.4 3.3 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DUF3043 PF11241.3 ESL09634.1 - 5.9 6.4 6.7 0.5 9.9 0.6 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3043) NPV_P10 PF05531.7 ESL09635.1 - 0.69 10.2 12.1 3.4 7.9 2.1 4.2 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 ESL09635.1 - 0.7 9.0 16.1 0.37 9.9 0.2 3.2 4 0 0 4 4 4 0 Reovirus sigma C capsid protein Pox_A_type_inc PF04508.7 ESL09635.1 - 10 6.2 14.9 2.7 7.9 0.9 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Pkinase PF00069.20 ESL09636.1 - 1.6e-39 135.6 0.0 2.3e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09636.1 - 1.4e-09 37.4 0.0 2e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL09636.1 - 0.00018 21.3 1.0 0.24 11.1 0.0 2.7 1 1 2 3 3 3 2 Phosphotransferase enzyme family Brix PF04427.13 ESL09637.1 - 3.1e-35 121.5 0.1 4e-35 121.1 0.1 1.1 1 0 0 1 1 1 1 Brix domain LRR_6 PF13516.1 ESL09638.1 - 4.7e-23 78.6 17.3 0.0042 17.0 0.0 10.6 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.2 ESL09638.1 - 2e-19 68.7 2.2 0.16 11.6 0.0 9.5 6 2 2 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL09638.1 - 1.9e-07 30.1 23.5 18 5.8 0.0 12.1 13 1 0 13 13 13 2 Leucine Rich Repeat LRR_8 PF13855.1 ESL09638.1 - 3.5e-06 26.6 22.7 0.11 12.2 0.1 9.2 6 3 2 8 8 8 4 Leucine rich repeat LRR_7 PF13504.1 ESL09638.1 - 0.31 11.3 34.3 25 5.6 0.2 11.6 12 2 2 14 14 14 0 Leucine rich repeat LRR_3 PF07725.7 ESL09638.1 - 8.3 6.3 6.3 3.5 7.5 0.2 3.0 3 0 0 3 3 3 0 Leucine Rich Repeat zf-C2HC_2 PF13913.1 ESL09639.1 - 3.2e-15 55.3 8.0 3.4e-07 29.7 2.0 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.1 ESL09639.1 - 0.019 15.2 0.4 2.2 8.7 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESL09639.1 - 0.022 15.0 2.0 6.1 7.4 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESL09639.1 - 0.023 15.0 2.1 5.4 7.5 0.1 2.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESL09639.1 - 0.043 13.7 0.1 3.5 7.6 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger RIP PF00161.14 ESL09639.1 - 0.089 11.9 0.1 0.089 11.9 0.1 1.9 2 0 0 2 2 2 0 Ribosome inactivating protein DUF1180 PF06679.7 ESL09639.1 - 0.31 10.8 5.9 0.16 11.8 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) zf-RING_3 PF14369.1 ESL09639.1 - 0.55 10.2 2.3 0.8 9.7 0.1 2.2 2 0 0 2 2 2 0 zinc-finger zf-Di19 PF05605.7 ESL09639.1 - 0.65 10.1 2.7 1.4 9.0 0.4 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Sgf11 PF08209.6 ESL09639.1 - 1.4 8.2 7.0 2.7 7.3 1.0 2.6 2 1 0 2 2 2 0 Sgf11 (transcriptional regulation protein) DUF2458 PF10454.4 ESL09640.1 - 0.011 15.5 11.1 0.022 14.6 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) RRM PF10378.4 ESL09641.1 - 0.024 14.1 0.0 0.061 12.9 0.0 1.7 1 0 0 1 1 1 0 Putative RRM domain zf-CCCH_2 PF14608.1 ESL09641.1 - 0.18 11.8 3.1 0.38 10.8 0.1 2.6 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type zf-CCCH PF00642.19 ESL09641.1 - 2.8 7.7 13.9 0.7 9.6 0.7 2.9 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SYF2 PF08231.7 ESL09642.1 - 0.021 14.9 1.9 0.03 14.4 1.3 1.2 1 0 0 1 1 1 0 SYF2 splicing factor Ribosomal_S17e PF00833.13 ESL09643.1 - 5.1e-51 171.5 2.9 6.8e-51 171.1 2.0 1.1 1 0 0 1 1 1 1 Ribosomal S17 Sld5 PF05916.6 ESL09643.1 - 0.086 13.1 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 GINS complex protein Abhydrolase_6 PF12697.2 ESL09644.1 - 0.00042 20.2 1.0 0.0011 18.8 0.7 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Na_sulph_symp PF00939.14 ESL09645.1 - 3.5e-20 72.3 40.7 2.8e-19 69.3 28.2 2.7 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 ESL09645.1 - 5.4e-13 48.2 35.5 7.3e-12 44.5 13.8 2.6 1 1 1 2 2 2 2 Citrate transporter DUF1697 PF08002.6 ESL09646.1 - 0.092 12.7 0.2 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) BAR PF03114.13 ESL09646.1 - 0.11 12.0 2.3 0.33 10.4 0.0 2.1 1 1 1 2 2 2 0 BAR domain AKAP7_NLS PF10469.4 ESL09647.1 - 1.5e-23 83.6 0.0 1.9e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 ESL09647.1 - 0.0015 18.2 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Pkinase PF00069.20 ESL09648.1 - 2e-73 246.7 0.0 2.4e-73 246.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09648.1 - 4.1e-31 107.9 0.0 6.2e-30 104.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1387 PF07139.6 ESL09648.1 - 0.15 11.5 0.1 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PLRV_ORF5 PF01690.12 ESL09649.1 - 9.2 5.2 20.2 19 4.2 14.0 1.4 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein PRP38 PF03371.10 ESL09650.1 - 2e-05 24.2 0.0 4e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 PRP38 family Unstab_antitox PF09720.5 ESL09650.1 - 0.071 12.8 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative addiction module component ATP-synt_ab PF00006.20 ESL09651.1 - 5.8e-36 124.0 0.1 4.4e-35 121.1 0.0 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL09651.1 - 1.5e-22 80.1 0.4 2.3e-22 79.5 0.3 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain LRR_4 PF12799.2 ESL09652.1 - 4.7e-10 38.8 6.6 0.00049 19.6 2.1 5.2 5 1 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL09652.1 - 2.8e-08 33.4 8.1 0.001 18.7 0.2 5.0 4 1 0 5 5 5 3 Leucine rich repeat LRR_1 PF00560.28 ESL09652.1 - 3.1e-05 23.4 17.7 0.15 12.1 1.2 6.6 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.1 ESL09652.1 - 0.021 14.3 0.0 5.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.1 ESL09652.1 - 0.036 14.1 14.9 1.4 9.2 0.2 5.1 5 1 1 6 6 6 0 Leucine Rich repeat LRR_7 PF13504.1 ESL09652.1 - 0.32 11.3 18.5 3.3 8.2 0.2 5.7 6 0 0 6 6 6 0 Leucine rich repeat NIF PF03031.13 ESL09653.1 - 2.1e-32 111.9 0.0 3e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESL09653.1 - 0.066 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RNA_pol_A_bac PF01000.21 ESL09654.1 - 6.4e-21 74.6 0.0 2.3e-20 72.8 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 ESL09654.1 - 1.3e-10 40.2 0.0 1.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.1 ESL09654.1 - 0.12 12.6 1.1 0.26 11.5 0.8 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_7 PF12838.2 ESL09654.1 - 0.13 12.7 0.9 0.29 11.5 0.6 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Ribosomal_L15e PF00827.12 ESL09655.1 - 9.9e-88 292.6 10.8 1.1e-87 292.4 7.5 1.0 1 0 0 1 1 1 1 Ribosomal L15 MCM PF00493.18 ESL09657.1 - 1.8e-125 418.1 0.0 2.5e-125 417.7 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESL09657.1 - 3.3e-14 53.4 0.0 1.7e-13 51.1 0.0 2.1 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.9 ESL09657.1 - 7e-07 29.0 0.0 3e-06 27.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESL09657.1 - 4.1e-05 22.8 0.0 0.0017 17.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESL09657.1 - 0.059 12.9 0.0 0.17 11.4 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HD_4 PF13328.1 ESL09658.1 - 0.0071 16.0 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 HD domain Rpr2 PF04032.11 ESL09658.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Apolipoprotein PF01442.13 ESL09658.1 - 0.09 12.2 0.3 0.15 11.5 0.2 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Cupin_8 PF13621.1 ESL09660.1 - 1.5e-44 152.3 0.0 2.4e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.9 ESL09660.1 - 4.1e-25 88.4 0.0 7.1e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.1 ESL09660.1 - 1.5e-09 37.4 3.4 3.8e-05 23.3 0.0 4.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESL09660.1 - 3.7e-09 36.4 9.0 0.0042 17.2 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL09660.1 - 3.1e-08 33.4 0.0 7.7e-05 22.5 0.0 4.0 3 0 0 3 3 3 1 Kelch motif Cupin_4 PF08007.7 ESL09660.1 - 6e-08 32.2 0.0 1.2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.17 ESL09660.1 - 0.027 14.7 0.0 0.072 13.3 0.0 1.7 1 0 0 1 1 1 0 JmjC domain, hydroxylase GTPase_Cys_C PF12631.2 ESL09660.1 - 0.075 13.4 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE GP38 PF05268.6 ESL09661.1 - 0.78 9.1 6.9 1.2 8.4 4.8 1.2 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 DUF1860 PF08949.5 ESL09661.1 - 2.4 7.7 6.0 4.5 6.7 4.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1860) Med4 PF10018.4 ESL09663.1 - 0.18 11.2 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 ELO PF01151.13 ESL09664.1 - 3.9e-82 275.3 19.1 4.5e-82 275.1 13.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ABA_GPCR PF12430.3 ESL09665.1 - 5e-14 51.8 0.8 5e-14 51.8 0.5 1.9 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 ESL09665.1 - 1.4e-11 44.2 0.0 3.1e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3735) Fer2_3 PF13085.1 ESL09666.1 - 3.4e-31 107.3 0.1 5.2e-31 106.7 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.22 ESL09666.1 - 0.014 15.1 2.9 0.02 14.5 0.7 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Pex2_Pex12 PF04757.9 ESL09667.1 - 6.6e-54 182.7 1.2 7.8e-54 182.4 0.8 1.0 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 ESL09667.1 - 0.00093 19.1 3.7 0.0017 18.3 2.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL09667.1 - 0.008 15.8 2.7 0.013 15.1 1.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESL09667.1 - 0.084 12.7 3.0 0.15 11.9 2.1 1.4 1 0 0 1 1 1 0 Ring finger domain Ank PF00023.25 ESL09668.1 - 3.2e-22 77.1 0.1 1.2e-06 28.0 0.0 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 ESL09668.1 - 2.2e-19 69.5 0.0 1.9e-09 37.6 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESL09668.1 - 1.2e-18 66.6 0.2 1.7e-09 37.6 0.0 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL09668.1 - 1.7e-15 55.5 0.6 0.0044 17.1 0.0 4.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 ESL09668.1 - 3.7e-14 52.7 0.4 1.7e-05 25.1 0.1 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) WD40 PF00400.27 ESL09669.1 - 1.7e-21 75.2 1.9 4.2e-06 26.4 0.4 4.9 4 1 0 4 4 4 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESL09669.1 - 0.0025 17.5 0.0 5.9 6.7 0.0 3.3 2 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.1 ESL09669.1 - 0.0078 16.4 0.4 0.15 12.3 0.0 3.0 3 1 0 3 3 3 1 PQQ-like domain COG5 PF10392.4 ESL09669.1 - 0.011 15.7 1.0 0.021 14.7 0.7 1.4 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Daxx PF03344.10 ESL09669.1 - 0.023 13.2 25.3 0.041 12.3 17.5 1.3 1 0 0 1 1 1 0 Daxx Family RRN3 PF05327.6 ESL09669.1 - 0.25 9.4 2.1 0.4 8.7 1.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 VID27 PF08553.5 ESL09669.1 - 0.36 8.9 7.3 0.52 8.4 5.0 1.3 1 0 0 1 1 1 0 VID27 cytoplasmic protein RNA_pol_3_Rpc31 PF11705.3 ESL09669.1 - 0.9 9.4 17.9 2 8.2 12.4 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Ycf1 PF05758.7 ESL09669.1 - 2.8 5.5 8.7 4.4 4.9 6.1 1.3 1 0 0 1 1 1 0 Ycf1 DUF2115 PF09888.4 ESL09669.1 - 3.1 7.8 5.3 6.3 6.8 3.7 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Paf1 PF03985.8 ESL09669.1 - 6.1 5.4 26.6 9.7 4.8 18.4 1.2 1 0 0 1 1 1 0 Paf1 CDC27 PF09507.5 ESL09669.1 - 7.2 5.7 22.5 14 4.7 15.6 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NOA36 PF06524.7 ESL09669.1 - 9.1 5.4 14.3 0.26 10.4 5.1 1.8 2 0 0 2 2 2 0 NOA36 protein Tubulin_C PF03953.12 ESL09670.1 - 9.9e-48 161.3 0.1 1.4e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Flavi_NS4B PF01349.12 ESL09671.1 - 0.025 13.5 0.0 0.055 12.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4B Acid_PPase PF12689.2 ESL09673.1 - 1.6e-46 157.9 0.0 1.9e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase Hydrolase PF00702.21 ESL09673.1 - 0.12 12.7 0.0 0.28 11.5 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF2608 PF11019.3 ESL09673.1 - 0.15 11.0 0.2 0.64 8.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) Actin PF00022.14 ESL09674.1 - 7.2e-120 400.0 0.0 8.2e-120 399.8 0.0 1.0 1 0 0 1 1 1 1 Actin APG6 PF04111.7 ESL09675.1 - 0.0011 18.0 5.9 0.0011 18.0 4.1 2.3 2 0 0 2 2 2 1 Autophagy protein Apg6 Lzipper-MIP1 PF14389.1 ESL09675.1 - 0.0084 16.1 0.5 0.0084 16.1 0.4 3.1 1 1 2 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 Omega_Repress PF07764.6 ESL09675.1 - 0.014 15.7 0.3 1.5 9.2 0.0 3.0 3 0 0 3 3 3 0 Omega Transcriptional Repressor DUF497 PF04365.8 ESL09675.1 - 0.035 14.0 0.3 0.74 9.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF497) FlaC_arch PF05377.6 ESL09675.1 - 0.62 9.9 6.8 19 5.2 0.0 4.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) WXG100 PF06013.7 ESL09675.1 - 1.9 8.5 6.1 0.89 9.6 0.7 3.2 4 0 0 4 4 4 0 Proteins of 100 residues with WXG TMPIT PF07851.8 ESL09675.1 - 3.1 6.7 10.3 1 8.3 2.2 2.4 2 0 0 2 2 2 0 TMPIT-like protein Nsp1_C PF05064.8 ESL09675.1 - 3.5 7.2 9.9 0.21 11.2 2.2 2.5 3 0 0 3 3 3 0 Nsp1-like C-terminal region DUF1664 PF07889.7 ESL09675.1 - 4 7.2 15.4 8.3 6.2 2.9 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) Laminin_II PF06009.7 ESL09675.1 - 7.3 6.3 11.5 7.6 6.2 2.2 3.7 3 1 0 3 3 3 0 Laminin Domain II PapD-like PF14874.1 ESL09676.1 - 2.7e-06 27.2 0.4 0.0084 16.0 0.1 4.6 5 0 0 5 5 5 1 Flagellar-associated PapD-like Motile_Sperm PF00635.21 ESL09676.1 - 4.3e-06 26.3 1.4 0.01 15.4 0.0 4.7 4 0 0 4 4 4 2 MSP (Major sperm protein) domain LRR_4 PF12799.2 ESL09677.1 - 2e-09 36.8 4.9 0.00078 19.0 0.0 3.2 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL09677.1 - 2.9e-06 26.9 1.6 0.00014 21.5 0.4 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 ESL09677.1 - 0.00076 19.1 0.2 2.8 8.3 0.0 3.8 3 1 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.1 ESL09677.1 - 0.0094 15.9 0.1 7.3 7.0 0.0 3.6 2 1 1 3 3 3 1 Leucine Rich repeat TerD PF02342.13 ESL09678.1 - 6.6e-50 169.0 0.0 7.7e-50 168.8 0.0 1.1 1 0 0 1 1 1 1 TerD domain DUF4042 PF13251.1 ESL09679.1 - 5.8e-13 48.7 7.4 4e-12 45.9 0.6 3.9 4 1 0 4 4 4 2 Domain of unknown function (DUF4042) HEAT_2 PF13646.1 ESL09679.1 - 2.7e-08 33.9 6.7 0.0071 16.6 0.3 4.4 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.17 ESL09679.1 - 9.4e-06 25.2 5.7 0.14 12.3 0.1 5.0 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.1 ESL09679.1 - 0.00053 20.3 11.3 0.032 14.7 0.2 6.4 7 1 1 8 8 8 1 HEAT-like repeat RNase_T PF00929.19 ESL09680.1 - 3.5e-19 69.6 0.0 5.9e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Exonuclease LRR_6 PF13516.1 ESL09683.1 - 2e-07 30.3 0.5 0.14 12.2 0.0 5.9 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.2 ESL09683.1 - 0.028 14.0 2.8 4.5 7.0 0.0 3.8 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESL09683.1 - 0.23 11.7 10.1 1.2e+02 3.5 0.1 7.0 7 0 0 7 7 7 0 Leucine rich repeat UPF0220 PF05255.6 ESL09684.1 - 1.9e-13 50.0 0.7 2.2e-13 49.7 0.5 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF4131 PF13567.1 ESL09684.1 - 0.04 13.3 0.0 0.04 13.3 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) PrgI PF12666.2 ESL09684.1 - 0.9 9.7 8.8 5.7 7.1 0.3 2.2 2 0 0 2 2 2 0 PrgI family protein DctQ PF04290.7 ESL09684.1 - 8.9 6.0 10.3 10 5.8 2.4 2.2 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Ribul_P_3_epim PF00834.14 ESL09685.1 - 1.7e-54 183.9 0.0 2.4e-54 183.4 0.0 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family TMP-TENI PF02581.12 ESL09685.1 - 0.0037 16.4 0.0 0.0056 15.8 0.0 1.2 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI QRPTase_C PF01729.14 ESL09685.1 - 0.028 13.9 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain LysR_substrate PF03466.15 ESL09685.1 - 0.1 11.6 1.3 4.5 6.3 0.0 2.7 1 1 1 3 3 3 0 LysR substrate binding domain SlyX PF04102.7 ESL09687.1 - 1.5 9.2 5.2 1.9 8.9 0.2 2.8 2 0 0 2 2 2 0 SlyX Ribosomal_L28e PF01778.12 ESL09688.1 - 2.4e-21 76.2 2.8 2.6e-21 76.2 1.6 1.3 1 1 0 1 1 1 1 Ribosomal L28e protein family 2-ph_phosp PF04029.9 ESL09688.1 - 0.11 11.4 0.5 0.14 11.0 0.4 1.2 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase Myosin_N PF02736.14 ESL09688.1 - 0.31 10.7 2.1 0.57 9.9 1.4 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Cyt-b5 PF00173.23 ESL09690.1 - 5.8e-26 90.0 0.0 1.5e-12 47.1 0.0 2.3 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.19 ESL09690.1 - 9.1e-11 41.7 0.0 2e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESL09690.1 - 7.3e-08 32.9 0.0 1.5e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESL09690.1 - 0.0017 18.3 0.1 0.0048 16.8 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain UCH PF00443.24 ESL09692.1 - 2.9e-23 82.3 0.0 5.5e-23 81.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL09692.1 - 1.2e-08 34.7 0.0 2.7e-08 33.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ADH_zinc_N PF00107.21 ESL09694.1 - 3.8e-07 29.6 0.1 9.6e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESL09694.1 - 2.9e-05 23.7 0.7 9.6e-05 22.1 0.1 2.1 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain SNAPc_SNAP43 PF09808.4 ESL09695.1 - 7.6e-09 35.5 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 MVP_shoulder PF11978.3 ESL09696.1 - 2.7e-44 149.8 0.0 6e-44 148.7 0.0 1.6 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.13 ESL09696.1 - 4.5e-36 122.6 7.3 1.4e-13 50.6 0.0 6.1 7 0 0 7 7 7 4 Major Vault Protein repeat DUF3601 PF12208.3 ESL09696.1 - 0.0076 16.1 0.0 1.7 8.6 0.0 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3601) Nol1_Nop2_Fmu PF01189.12 ESL09697.1 - 4.3e-22 78.7 0.0 7.2e-16 58.3 0.0 2.7 1 1 1 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 ESL09697.1 - 0.0071 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ribul_P_3_epim PF00834.14 ESL09697.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family NAC PF01849.13 ESL09698.1 - 2.5e-14 52.5 0.0 5.6e-14 51.4 0.0 1.7 1 0 0 1 1 1 1 NAC domain UBA PF00627.26 ESL09698.1 - 0.13 12.1 0.3 0.3 10.9 0.2 1.7 1 0 0 1 1 1 0 UBA/TS-N domain ALF PF03752.8 ESL09698.1 - 4.4 7.2 8.9 15 5.4 1.4 2.9 3 0 0 3 3 3 0 Short repeats of unknown function ATP-grasp_4 PF13535.1 ESL09699.1 - 4.3e-26 91.7 0.0 5.5e-17 62.0 0.0 2.6 3 0 0 3 3 3 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESL09699.1 - 1.2e-07 30.7 0.0 2.9e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 ESL09699.1 - 8.8e-06 25.6 0.0 6.3e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 ESL09699.1 - 5.8e-05 22.4 0.0 0.00077 18.8 0.0 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain DUF588 PF04535.7 ESL09700.1 - 0.13 11.8 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF588) LRR_6 PF13516.1 ESL09701.1 - 3.5e-17 60.5 2.2 0.087 12.9 0.0 7.7 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.28 ESL09701.1 - 1.6e-07 30.3 0.6 3.8 7.9 0.0 6.9 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_4 PF12799.2 ESL09701.1 - 3.8e-07 29.5 3.0 0.5 10.0 0.1 5.1 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL09701.1 - 0.00019 21.1 3.0 2.9 7.7 0.0 4.6 3 1 2 5 5 5 2 Leucine rich repeat Macoilin PF09726.4 ESL09701.1 - 0.011 14.0 12.3 0.018 13.3 8.5 1.2 1 0 0 1 1 1 0 Transmembrane protein LRR_7 PF13504.1 ESL09701.1 - 0.029 14.5 6.3 4.6 7.8 0.0 5.9 6 1 0 6 6 6 0 Leucine rich repeat Ribosomal_L37e PF01907.14 ESL09702.1 - 1.4e-26 92.0 8.2 2.6e-26 91.1 5.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.2 ESL09702.1 - 0.066 13.0 0.7 0.12 12.2 0.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_6 PF14599.1 ESL09702.1 - 0.088 12.6 0.5 0.15 11.9 0.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon ATE_N PF04376.8 ESL09702.1 - 0.33 10.7 5.9 0.8 9.5 2.6 2.0 1 1 1 2 2 2 0 Arginine-tRNA-protein transferase, N terminus Ribosomal_S13_N PF08069.7 ESL09703.1 - 4.6e-24 84.0 1.1 6.6e-24 83.5 0.1 1.8 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 ESL09703.1 - 2.9e-23 81.4 0.3 3.5e-23 81.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S15 DUF2730 PF10805.3 ESL09705.1 - 0.017 14.8 0.3 0.25 11.1 0.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) Fungal_trans_2 PF11951.3 ESL09705.1 - 0.018 13.6 0.1 0.022 13.3 0.0 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF3450 PF11932.3 ESL09705.1 - 0.057 12.6 2.1 2.9 7.0 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Tropomyosin_1 PF12718.2 ESL09705.1 - 0.081 12.7 5.4 0.93 9.3 0.3 2.8 2 1 1 3 3 3 0 Tropomyosin like DUF3573 PF12097.3 ESL09705.1 - 0.12 10.9 0.1 0.15 10.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CENP-F_leu_zip PF10473.4 ESL09705.1 - 6.5 6.6 7.9 3.3 7.5 3.1 2.2 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Gtr1_RagA PF04670.7 ESL09706.1 - 4e-91 304.2 0.0 7.4e-91 303.4 0.0 1.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ras PF00071.17 ESL09706.1 - 2.2e-06 27.1 0.0 4.8e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 Ras family Miro PF08477.8 ESL09706.1 - 0.00094 19.6 0.0 0.0026 18.2 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL09706.1 - 0.0015 17.8 0.0 0.0042 16.3 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family IPPT PF01715.12 ESL09706.1 - 0.0082 15.1 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 IPP transferase GTP_EFTU PF00009.22 ESL09706.1 - 0.063 12.6 0.0 0.35 10.2 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain THF_DHG_CYH_C PF02882.14 ESL09708.1 - 5.3e-41 139.3 0.7 2e-40 137.4 0.5 1.8 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 ESL09708.1 - 7.1e-26 90.5 0.0 1e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF2450 PF10475.4 ESL09710.1 - 6.4e-15 54.8 9.2 1.5e-14 53.6 6.4 1.6 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 ESL09710.1 - 3.4e-10 40.0 1.8 1.9e-08 34.3 0.4 2.4 2 0 0 2 2 2 2 Protein of unknown function C-terminus (DUF2451) Redoxin PF08534.5 ESL09710.1 - 0.078 12.5 0.1 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Redoxin PSRP-3_Ycf65 PF04839.8 ESL09710.1 - 0.1 12.6 0.0 0.34 10.9 0.0 2.0 1 0 0 1 1 1 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Amidohydro_4 PF13147.1 ESL09711.1 - 9.8e-11 42.1 0.2 1.7e-09 38.1 0.1 2.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 ESL09711.1 - 1.2e-07 31.7 1.1 8.9e-07 28.8 0.8 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 ESL09711.1 - 5.4e-07 29.3 0.1 1.4e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 ESL09711.1 - 3.6e-06 26.4 0.1 0.049 12.8 0.0 2.3 2 1 0 2 2 2 2 Amidohydrolase family ACOX PF01756.14 ESL09712.1 - 9e-09 34.9 0.0 1.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Cupin_3 PF05899.7 ESL09712.1 - 0.041 13.2 0.0 0.29 10.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF861) AhpC-TSA PF00578.16 ESL09713.1 - 3.1e-37 127.0 0.0 4.5e-37 126.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESL09713.1 - 1.9e-15 56.6 0.0 2.5e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 ESL09713.1 - 2.9e-14 52.4 0.1 5.5e-14 51.5 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Cyt-b5 PF00173.23 ESL09714.1 - 3.8e-06 26.5 0.0 5.5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_2 PF07719.12 ESL09715.1 - 0.065 13.1 1.3 0.21 11.5 0.9 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1749 PF08538.5 ESL09716.1 - 3.1e-16 59.1 0.0 6.3e-16 58.1 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 ESL09716.1 - 4.5e-08 33.2 0.0 6.1e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL09716.1 - 0.0038 16.7 0.0 0.0046 16.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESL09716.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family TPR_11 PF13414.1 ESL09717.1 - 2e-17 62.5 5.3 7e-10 38.4 0.3 2.7 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESL09717.1 - 9.3e-16 56.4 2.0 8.9e-07 28.3 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09717.1 - 7e-15 53.9 0.4 3.6e-07 29.5 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09717.1 - 1.6e-08 33.7 1.4 5e-05 22.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09717.1 - 2e-08 34.6 0.9 0.0034 18.0 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL09717.1 - 1.8e-07 30.3 1.1 0.0028 17.3 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL09717.1 - 7.2e-07 29.0 5.2 1.5e-05 24.8 0.5 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL09717.1 - 0.00019 21.4 0.3 0.18 12.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09717.1 - 0.00019 21.7 0.2 0.013 16.0 0.0 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL09717.1 - 0.00049 20.3 1.2 0.88 10.1 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL09717.1 - 0.00076 19.7 0.1 0.071 13.4 0.1 2.5 1 1 0 1 1 1 1 Tetratricopeptide repeat zf-MYND PF01753.13 ESL09717.1 - 0.0012 18.6 6.1 0.0028 17.4 4.2 1.6 1 0 0 1 1 1 1 MYND finger MIT PF04212.13 ESL09717.1 - 0.008 16.0 1.0 1.1 9.2 0.1 2.5 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 ESL09717.1 - 0.013 15.4 1.6 0.027 14.4 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL09717.1 - 0.029 14.5 0.5 0.11 12.6 0.1 2.2 2 1 1 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Ecl1 PF12855.2 ESL09717.1 - 0.06 12.6 1.0 0.13 11.5 0.7 1.5 1 0 0 1 1 1 0 Life-span regulatory factor TPR_3 PF07720.7 ESL09717.1 - 0.07 12.9 0.7 0.42 10.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL09717.1 - 0.11 12.3 1.8 0.32 10.9 0.2 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Ribosomal_L30 PF00327.15 ESL09718.1 - 0.0048 16.4 0.0 0.012 15.1 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Atg14 PF10186.4 ESL09718.1 - 1.2 8.0 8.4 0.29 10.0 2.9 2.0 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF872 PF05915.7 ESL09719.1 - 9.1e-10 38.4 0.1 9.1e-10 38.4 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) DUF4013 PF13197.1 ESL09719.1 - 0.0011 18.3 0.1 0.0014 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4013) Claudin_2 PF13903.1 ESL09719.1 - 0.0084 15.8 0.1 0.0095 15.6 0.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction MORN PF02493.15 ESL09722.1 - 0.0009 18.8 0.0 0.54 10.0 0.0 4.0 4 0 0 4 4 4 1 MORN repeat Amastin PF07344.6 ESL09723.1 - 2.8e-06 27.0 3.4 3.3e-06 26.7 2.3 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein FixP_N PF14715.1 ESL09723.1 - 5.9 6.3 5.5 7.5 6.0 0.5 2.1 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Ribosomal_S17e PF00833.13 ESL09725.1 - 1.1e-51 173.6 2.9 1.3e-51 173.5 2.0 1.0 1 0 0 1 1 1 1 Ribosomal S17 Sld5 PF05916.6 ESL09725.1 - 0.12 12.7 0.4 0.14 12.4 0.3 1.4 1 1 0 1 1 1 0 GINS complex protein BCDHK_Adom3 PF10436.4 ESL09726.1 - 4.4e-31 107.6 0.0 8.3e-31 106.7 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESL09726.1 - 5.7e-16 58.2 0.0 4.7e-15 55.2 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESL09726.1 - 2.3e-05 24.0 0.0 6.5e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3596 PF12167.3 ESL09726.1 - 0.087 12.3 0.0 0.28 10.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3596) RabGAP-TBC PF00566.13 ESL09727.1 - 4.2e-20 72.1 0.6 6.9e-20 71.4 0.4 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Erythro_esteras PF05139.9 ESL09727.1 - 0.066 12.3 0.0 0.25 10.4 0.0 1.8 2 0 0 2 2 2 0 Erythromycin esterase Pkinase PF00069.20 ESL09728.1 - 1e-62 211.6 0.0 1.2e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09728.1 - 1.5e-28 99.6 0.0 1.7e-27 96.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESL09728.1 - 1.5e-21 76.0 9.8 3.1e-21 75.0 6.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESL09728.1 - 4.6e-05 23.2 0.0 9.2e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL09728.1 - 0.026 13.4 0.0 0.039 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.15 ESL09728.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase FYVE_2 PF02318.11 ESL09728.1 - 0.72 9.7 7.4 0.34 10.8 3.2 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger IBR PF01485.16 ESL09728.1 - 1.3 8.9 9.3 0.2 11.5 3.2 2.1 2 0 0 2 2 2 0 IBR domain zf-B_box PF00643.19 ESL09728.1 - 2.4 8.1 12.1 4.4 7.2 1.1 3.5 3 0 0 3 3 3 0 B-box zinc finger HypA PF01155.14 ESL09728.1 - 7.3 6.3 7.5 3.8 7.2 2.4 2.4 2 1 1 3 3 3 0 Hydrogenase expression/synthesis hypA family Snf7 PF03357.16 ESL09729.1 - 1.1e-19 70.5 5.5 1.3e-19 70.1 3.8 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.9 ESL09729.1 - 0.014 14.8 1.6 0.052 12.9 1.1 1.9 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Lumazine_bd PF12870.2 ESL09729.1 - 1.5 8.9 5.0 2.7 8.0 0.1 2.4 1 1 1 2 2 2 0 Lumazine-binding domain Ribosomal_S2 PF00318.15 ESL09730.1 - 1.9 7.6 7.9 0.072 12.2 1.1 1.9 2 0 0 2 2 2 0 Ribosomal protein S2 Drf_FH1 PF06346.7 ESL09731.1 - 0.0033 16.9 10.8 0.0061 16.0 7.5 1.3 1 0 0 1 1 1 1 Formin Homology Region 1 DUF643 PF04867.7 ESL09731.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF643) PAT1 PF09770.4 ESL09732.1 - 0.41 8.8 29.8 0.5 8.5 20.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WW PF00397.21 ESL09733.1 - 1.5e-08 34.3 0.1 3.3e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 WW domain Utp11 PF03998.8 ESL09734.1 - 9.4e-50 169.6 18.8 9.4e-50 169.6 13.0 2.0 1 1 1 2 2 2 1 Utp11 protein PAS_10 PF13596.1 ESL09734.1 - 0.13 12.5 4.4 11 6.3 0.0 3.5 4 0 0 4 4 4 0 PAS domain Peptidase_M14 PF00246.19 ESL09735.1 - 9.8e-28 97.5 0.0 2.5e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESL09735.1 - 0.00015 20.7 0.0 0.00024 20.1 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family zf-CCCH PF00642.19 ESL09737.1 - 0.0015 18.2 9.3 0.066 12.9 2.8 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Consortin_C PF15281.1 ESL09738.1 - 0.081 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Consortin C-terminus SSB PF00436.20 ESL09739.1 - 0.084 12.7 0.2 0.25 11.1 0.1 1.9 2 0 0 2 2 2 0 Single-strand binding protein family CEP19 PF14933.1 ESL09740.1 - 7.3e-39 133.6 0.0 1.3e-38 132.7 0.0 1.4 1 0 0 1 1 1 1 CEP19-like protein FTZ PF03867.9 ESL09741.1 - 0.04 13.1 0.3 0.043 13.0 0.2 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region RRM_1 PF00076.17 ESL09742.1 - 1.4e-34 117.4 0.0 2.8e-16 58.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL09742.1 - 2.1e-29 101.3 0.1 1.1e-15 57.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL09742.1 - 3.3e-12 46.0 0.0 3e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESL09742.1 - 4e-05 23.2 0.2 0.2 11.4 0.0 3.7 2 2 0 2 2 2 2 Limkain b1 Suf PF05843.9 ESL09742.1 - 0.028 14.1 0.6 0.033 13.9 0.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.3 ESL09742.1 - 0.062 12.6 0.4 0.081 12.2 0.3 1.2 1 0 0 1 1 1 0 Spt20 family DUF3994 PF13159.1 ESL09742.1 - 0.14 12.4 1.0 0.25 11.6 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) Tetraspannin PF00335.15 ESL09743.1 - 4.4e-23 81.7 9.8 5.5e-23 81.3 6.8 1.1 1 0 0 1 1 1 1 Tetraspanin family DZR PF12773.2 ESL09743.1 - 0.071 12.9 0.6 2.3 8.1 0.2 2.5 2 0 0 2 2 2 0 Double zinc ribbon TniQ PF06527.6 ESL09743.1 - 0.072 13.2 0.2 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 TniQ Cytochrom_NNT PF03264.9 ESL09743.1 - 8.6 5.7 9.7 0.22 10.9 0.2 2.5 3 0 0 3 3 3 0 NapC/NirT cytochrome c family, N-terminal region Mak10 PF04112.8 ESL09744.1 - 0.025 13.8 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DctQ PF04290.7 ESL09744.1 - 0.031 14.0 0.3 0.042 13.6 0.2 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF2189 PF09955.4 ESL09744.1 - 0.23 11.4 4.0 0.36 10.7 2.7 1.5 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2189) DUF21 PF01595.15 ESL09745.1 - 3.9e-25 88.1 8.0 5.5e-25 87.7 5.5 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESL09745.1 - 0.0043 16.8 0.0 0.07 12.9 0.0 2.5 2 0 0 2 2 2 1 CBS domain Abhydrolase_6 PF12697.2 ESL09748.1 - 0.0032 17.3 0.1 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase PF00151.14 ESL09748.1 - 0.054 12.7 0.0 0.08 12.1 0.0 1.1 1 0 0 1 1 1 0 Lipase Esterase PF00756.15 ESL09748.1 - 0.12 11.7 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Putative esterase GalKase_gal_bdg PF10509.4 ESL09749.1 - 9.5e-19 66.4 0.1 2.9e-18 64.8 0.0 1.9 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 ESL09749.1 - 2.3e-09 37.3 0.1 1.1e-08 35.1 0.0 2.1 2 0 0 2 2 2 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESL09749.1 - 0.00042 20.3 0.7 0.00088 19.2 0.0 1.9 2 1 0 2 2 2 1 GHMP kinases N terminal domain Mon1 PF03164.9 ESL09750.1 - 3.4e-36 124.7 0.0 1.5e-35 122.5 0.0 1.9 2 0 0 2 2 2 1 Trafficking protein Mon1 Sua5_yciO_yrdC PF01300.13 ESL09751.1 - 1.7e-49 167.5 0.0 2.4e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 ESL09751.1 - 9.1e-08 32.2 0.0 1.4e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding DAP3 PF10236.4 ESL09752.1 - 4.3e-29 101.4 0.0 6.2e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.1 ESL09752.1 - 0.0088 16.0 0.0 0.025 14.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain ResIII PF04851.10 ESL09752.1 - 0.0096 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 ESL09752.1 - 0.013 15.0 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 ESL09752.1 - 0.061 13.0 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 Archaeal ATPase NACHT PF05729.7 ESL09752.1 - 0.07 12.7 0.0 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.1 ESL09752.1 - 0.08 12.8 0.2 0.5 10.2 0.0 2.3 2 1 1 3 3 3 0 AAA domain AAA_19 PF13245.1 ESL09752.1 - 0.083 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain T2SE PF00437.15 ESL09752.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 ESL09752.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 ESL09752.1 - 0.22 10.1 0.0 0.33 9.5 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain PIF1 PF05970.9 ESL09752.1 - 0.25 10.2 0.0 0.37 9.6 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase PIF1 PF05970.9 ESL09753.1 - 2.2e-35 122.3 0.0 2.1e-32 112.5 0.0 2.6 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 ESL09753.1 - 2e-09 37.3 0.3 8.7e-09 35.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESL09753.1 - 2.6e-06 27.0 0.7 7.9e-06 25.5 0.5 1.8 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 ESL09753.1 - 0.0013 18.8 0.0 0.0063 16.6 0.0 2.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.1 ESL09753.1 - 0.0037 16.8 0.5 3.1 7.3 0.2 2.6 1 1 0 2 2 2 2 AAA domain DEAD PF00270.24 ESL09753.1 - 0.0059 16.1 0.0 0.029 13.8 0.0 1.9 1 1 1 2 2 2 1 DEAD/DEAH box helicase IstB_IS21 PF01695.12 ESL09753.1 - 0.0078 15.6 0.1 0.2 11.0 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein PhoH PF02562.11 ESL09753.1 - 0.0085 15.3 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein Viral_helicase1 PF01443.13 ESL09753.1 - 0.01 15.3 0.1 1.9 7.9 0.0 3.3 2 2 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 ESL09753.1 - 0.011 15.1 0.1 0.016 14.4 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain TrwB_AAD_bind PF10412.4 ESL09753.1 - 0.03 12.9 0.0 0.06 11.9 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.10 ESL09753.1 - 0.039 13.6 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 NTPase DUF2075 PF09848.4 ESL09753.1 - 0.093 11.6 0.1 0.18 10.7 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 ESL09753.1 - 0.11 12.0 0.1 0.28 10.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SE PF00437.15 ESL09753.1 - 0.14 11.0 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Pox_A32 PF04665.7 ESL09753.1 - 0.14 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein Multi_ubiq PF14452.1 ESL09754.1 - 0.072 13.0 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Multiubiquitin EF-hand_7 PF13499.1 ESL09754.1 - 0.087 12.9 0.1 2 8.6 0.0 2.5 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 ESL09754.1 - 0.11 12.4 0.3 3.9 7.6 0.1 3.1 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.1 ESL09754.1 - 0.16 11.5 0.1 0.76 9.4 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair Kri1_C PF12936.2 ESL09755.1 - 6.2e-24 83.7 0.3 6.2e-24 83.7 0.2 2.6 2 0 0 2 2 2 1 KRI1-like family C-terminal Kri1 PF05178.7 ESL09755.1 - 1.9e-23 82.6 12.2 1.9e-23 82.6 8.5 4.5 4 0 0 4 4 4 1 KRI1-like family KorB PF08535.5 ESL09756.1 - 0.032 14.3 0.4 0.082 13.0 0.2 1.7 1 1 0 1 1 1 0 KorB domain LURAP PF14854.1 ESL09756.1 - 0.032 13.9 0.2 0.063 12.9 0.1 1.5 1 0 0 1 1 1 0 Leucine rich adaptor protein NA37 PF04245.8 ESL09756.1 - 0.091 12.0 0.2 0.17 11.1 0.1 1.4 1 1 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DUF948 PF06103.6 ESL09756.1 - 1.4 8.8 4.7 0.35 10.7 0.2 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Mak10 PF04112.8 ESL09757.1 - 1.6e-08 33.9 0.0 4.5e-08 32.4 0.0 1.7 1 1 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase dsDNA_bind PF01984.15 ESL09758.1 - 2.3e-24 85.4 10.1 2.5e-24 85.2 7.0 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain UPF0154 PF03672.8 ESL09758.1 - 0.47 10.1 2.7 5.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Pyr_redox_2 PF07992.9 ESL09759.1 - 8.7e-36 123.6 0.0 3.4e-35 121.7 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESL09759.1 - 9.6e-27 93.1 0.0 1.9e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ESL09759.1 - 1.7e-22 79.6 0.1 1.6e-17 63.6 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ESL09759.1 - 5.4e-07 28.4 0.7 0.00095 17.7 0.1 3.0 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox_3 PF13738.1 ESL09759.1 - 1.5e-06 28.4 0.2 8.6e-05 22.6 0.0 3.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESL09759.1 - 3.2e-06 26.2 0.3 0.001 17.9 0.1 2.8 3 0 0 3 3 3 2 FAD binding domain GIDA PF01134.17 ESL09759.1 - 0.00024 20.0 2.5 0.0005 19.0 0.4 2.4 2 1 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.19 ESL09759.1 - 0.0003 19.8 2.0 0.081 11.8 0.4 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 ESL09759.1 - 0.0039 16.3 0.1 0.029 13.4 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 ESL09759.1 - 0.021 14.6 0.3 2.9 7.6 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESL09759.1 - 0.038 14.0 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESL09759.1 - 0.074 12.1 0.1 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Thi4 family PARP_regulatory PF01358.13 ESL09760.1 - 3.7e-06 25.7 0.0 1.6e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Poly A polymerase regulatory subunit HSP90 PF00183.13 ESL09761.1 - 3.7e-181 603.1 9.5 4.4e-181 602.9 6.6 1.0 1 0 0 1 1 1 1 Hsp90 protein LOH1CR12 PF10158.4 ESL09761.1 - 0.013 15.3 0.3 0.034 13.9 0.2 1.7 1 0 0 1 1 1 0 Tumour suppressor protein FAR1 PF03101.10 ESL09761.1 - 0.051 14.0 3.5 0.12 12.8 0.3 2.4 2 0 0 2 2 2 0 FAR1 DNA-binding domain ARL2_Bind_BART PF11527.3 ESL09761.1 - 0.2 11.4 7.0 1.4 8.6 0.3 2.5 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART RNA_pol_Rpb1_2 PF00623.15 ESL09762.1 - 8.4e-49 165.7 0.0 1.5e-48 164.8 0.0 1.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 tRNA-synt_2 PF00152.15 ESL09763.1 - 5.5e-88 294.9 0.0 6.8e-88 294.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESL09763.1 - 6.4e-09 35.5 0.2 1.2e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESL09763.1 - 7.9e-09 35.0 0.1 9.8e-05 21.6 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ESL09763.1 - 0.0064 16.0 0.2 1.2 8.6 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) Peptidase_M20 PF01546.23 ESL09764.1 - 1.7e-15 57.0 0.2 2.4e-15 56.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 ESL09764.1 - 5.8e-08 31.8 0.5 4.9e-07 28.8 0.1 2.1 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase M20_dimer PF07687.9 ESL09764.1 - 5.9e-08 32.4 0.1 1.2e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 ESL09764.1 - 0.00022 21.0 0.1 0.00071 19.3 0.1 1.9 1 1 0 1 1 1 1 Peptidase family M28 Baculo_PEP_C PF04513.7 ESL09765.1 - 0.086 12.6 17.6 1.4 8.7 0.7 5.4 3 2 3 7 7 7 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 ESL09765.1 - 3.4 7.4 21.1 1.1 9.1 0.1 5.9 1 1 5 7 7 7 0 Protein of unknown function (DUF1664) RRM_1 PF00076.17 ESL09766.1 - 1.2e-21 76.0 0.0 1.8e-13 49.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL09766.1 - 5.5e-17 61.5 0.0 2.5e-13 49.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL09766.1 - 3e-06 26.9 0.0 0.00093 19.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S28e PF01200.13 ESL09766.1 - 0.02 14.6 0.2 0.11 12.2 0.1 2.1 1 1 0 1 1 1 0 Ribosomal protein S28e Usp PF00582.21 ESL09767.1 - 6.4e-07 29.6 6.2 0.00072 19.7 0.0 3.3 4 0 0 4 4 4 2 Universal stress protein family Mito_fiss_reg PF05308.6 ESL09767.1 - 0.17 11.2 12.0 0.071 12.4 4.0 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator PEPCK_ATP PF01293.15 ESL09769.1 - 4.4e-47 160.6 0.0 5.6e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF3508 PF12018.3 ESL09770.1 - 2.1e-08 33.4 0.0 6.8e-07 28.5 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3508) DUF3235 PF11574.3 ESL09770.1 - 0.047 13.9 0.2 35 4.7 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3235) RRM_6 PF14259.1 ESL09772.1 - 2e-05 24.4 0.0 0.00065 19.6 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL09772.1 - 5.2e-05 22.7 0.0 0.0011 18.5 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hyd_WA PF06462.7 ESL09772.1 - 0.16 11.6 0.3 0.46 10.1 0.0 2.0 3 0 0 3 3 3 0 Propeller PRA1 PF03208.14 ESL09773.1 - 0.041 13.2 4.1 0.032 13.5 1.5 1.9 2 1 0 2 2 2 0 PRA1 family protein Complex1_LYR_1 PF13232.1 ESL09775.1 - 1.7e-08 34.5 0.7 4e-08 33.3 0.5 1.7 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 ESL09775.1 - 8.2e-07 28.7 0.1 8.2e-07 28.7 0.1 2.6 2 1 1 3 3 3 1 Complex 1 protein (LYR family) Hist_deacetyl PF00850.14 ESL09776.1 - 1.2e-69 235.0 0.0 1.4e-69 234.7 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain PHF5 PF03660.9 ESL09777.1 - 3.7e-33 113.7 11.0 4e-33 113.6 7.6 1.0 1 0 0 1 1 1 1 PHF5-like protein zf-C3HC4_2 PF13923.1 ESL09777.1 - 5.9 6.9 9.4 2.3 8.3 2.7 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Tim17 PF02466.14 ESL09778.1 - 9.6e-17 61.2 8.9 1.3e-16 60.8 6.2 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family BNR_3 PF13859.1 ESL09780.1 - 2.6e-69 233.6 0.3 3.2e-69 233.3 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESL09780.1 - 1.5e-16 60.5 0.3 5.2e-16 58.7 0.2 1.7 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESL09780.1 - 3.8e-07 28.9 7.4 0.2 11.6 0.2 4.1 3 0 0 3 3 3 3 BNR/Asp-box repeat Tubulin_C PF03953.12 ESL09781.1 - 2e-34 118.3 0.0 2.5e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain AAA_28 PF13521.1 ESL09783.1 - 1.6e-25 89.9 0.0 2.8e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09783.1 - 0.00013 22.7 0.0 0.00031 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain ArgK PF03308.11 ESL09783.1 - 0.0062 15.3 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 ArgK protein DAP3 PF10236.4 ESL09783.1 - 0.0062 15.5 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 KTI12 PF08433.5 ESL09783.1 - 0.0068 15.6 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Pox_A32 PF04665.7 ESL09783.1 - 0.0094 15.2 0.3 2 7.6 0.0 2.9 3 0 0 3 3 3 1 Poxvirus A32 protein AAA_18 PF13238.1 ESL09783.1 - 0.047 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Coatomer_WDAD PF04053.9 ESL09784.1 - 0.17 10.6 0.1 0.59 8.8 0.0 1.8 3 0 0 3 3 3 0 Coatomer WD associated region zf-LSD1 PF06943.7 ESL09785.1 - 1.8e-11 43.4 4.9 1.8e-11 43.4 3.4 2.6 2 1 0 2 2 2 1 LSD1 zinc finger FLO_LFY PF01698.11 ESL09785.1 - 0.0096 14.8 2.1 0.011 14.6 1.4 1.1 1 0 0 1 1 1 1 Floricaula / Leafy protein DUF1738 PF08401.6 ESL09785.1 - 0.043 13.5 0.9 0.064 12.9 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) MTBP_N PF14918.1 ESL09785.1 - 0.061 12.7 0.9 0.087 12.2 0.6 1.1 1 0 0 1 1 1 0 MDM2-binding zinc_ribbon_4 PF13717.1 ESL09785.1 - 0.52 10.0 0.1 0.52 10.0 0.1 3.8 4 0 0 4 4 4 0 zinc-ribbon domain Paf1 PF03985.8 ESL09785.1 - 1.4 7.5 10.4 1.7 7.2 7.2 1.0 1 0 0 1 1 1 0 Paf1 zinc_ribbon_5 PF13719.1 ESL09785.1 - 1.9 8.1 14.5 0.53 9.8 0.2 3.8 3 1 1 4 4 4 0 zinc-ribbon domain Nucleo_P87 PF07267.6 ESL09785.1 - 7.9 5.0 8.2 9.8 4.7 5.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.9 ESL09785.1 - 8.3 4.3 9.3 10 4.0 6.5 1.0 1 0 0 1 1 1 0 CDC45-like protein IQ PF00612.22 ESL09786.1 - 6.9e-14 50.1 5.5 0.0016 17.9 0.1 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif LRR_4 PF12799.2 ESL09786.1 - 2.6e-11 42.8 9.4 6.9e-06 25.5 0.1 4.7 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL09786.1 - 7.6e-07 28.7 14.2 0.0012 18.5 0.0 4.1 3 1 1 4 4 4 2 Leucine rich repeat LRR_9 PF14580.1 ESL09786.1 - 6.5e-05 22.5 0.2 0.0026 17.3 0.0 2.7 2 1 0 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.28 ESL09786.1 - 0.0013 18.5 19.4 1.3 9.3 0.0 6.9 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.1 ESL09786.1 - 0.064 13.3 14.0 11 6.4 0.0 5.9 6 1 1 7 7 7 0 Leucine Rich repeat LRR_7 PF13504.1 ESL09786.1 - 0.55 10.6 17.6 8.2 7.1 0.0 7.0 7 0 0 7 7 7 0 Leucine rich repeat Sec23_helical PF04815.10 ESL09787.1 - 3.4e-28 97.0 0.1 5.3e-28 96.4 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.17 ESL09787.1 - 2.6e-06 27.0 0.0 2.4e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Gelsolin repeat Peptidase_M41 PF01434.13 ESL09789.1 - 4.2e-53 179.9 0.0 9.4e-53 178.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESL09789.1 - 7.9e-35 119.9 0.0 3.4e-34 117.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL09789.1 - 0.00047 20.2 0.5 0.27 11.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.9 ESL09789.1 - 0.00078 19.4 0.0 0.0021 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 ESL09789.1 - 0.0023 18.7 0.1 0.017 15.8 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 ESL09789.1 - 0.0081 15.8 1.9 0.031 14.0 1.3 2.0 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 ESL09789.1 - 0.0083 15.1 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESL09789.1 - 0.0089 15.7 0.7 0.071 12.8 0.5 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESL09789.1 - 0.015 15.5 0.1 0.22 11.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 ESL09789.1 - 0.032 14.0 0.0 0.099 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESL09789.1 - 0.034 14.0 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESL09789.1 - 0.036 13.4 0.9 0.088 12.2 0.6 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.1 ESL09789.1 - 0.045 13.7 2.8 0.055 13.4 0.1 2.4 3 0 0 3 3 3 0 AAA ATPase domain Mg_chelatase PF01078.16 ESL09789.1 - 0.066 12.3 1.1 0.12 11.4 0.2 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 ESL09789.1 - 0.071 12.4 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Peptidase_M50B PF13398.1 ESL09789.1 - 0.074 12.4 0.3 0.2 11.0 0.2 1.7 1 0 0 1 1 1 0 Peptidase M50B-like Plasmodium_Vir PF05795.6 ESL09789.1 - 0.39 9.8 0.1 0.98 8.5 0.0 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein WD40 PF00400.27 ESL09790.1 - 2.2e-29 100.2 4.4 1.9e-10 40.2 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat PQQ_2 PF13360.1 ESL09790.1 - 0.00032 20.2 0.1 0.00083 18.8 0.0 1.7 2 0 0 2 2 2 1 PQQ-like domain Nup160 PF11715.3 ESL09790.1 - 0.022 12.9 1.3 0.16 10.0 0.1 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Complex1_LYR PF05347.10 ESL09791.1 - 1.7e-11 43.7 0.3 3.2e-11 42.8 0.2 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESL09791.1 - 2.9e-08 33.8 0.4 5.8e-08 32.8 0.3 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Sec3_C PF09763.4 ESL09792.1 - 1.8e-99 333.7 0.0 2.4e-99 333.4 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Robl_LC7 PF03259.12 ESL09796.1 - 3.7e-22 77.7 0.0 4e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain Ras PF00071.17 ESL09796.1 - 0.012 14.9 0.0 0.013 14.8 0.0 1.1 1 0 0 1 1 1 0 Ras family DUF1155 PF06633.6 ESL09797.1 - 0.16 11.2 1.1 0.28 10.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1155) HEAT_2 PF13646.1 ESL09798.1 - 6.3e-11 42.4 15.0 0.17 12.2 0.1 7.3 2 2 4 7 7 7 6 HEAT repeats HEAT_EZ PF13513.1 ESL09798.1 - 3.3e-09 36.9 7.1 0.019 15.4 0.3 7.3 6 1 1 7 7 7 2 HEAT-like repeat CTD PF12815.2 ESL09798.1 - 1.1e-08 35.5 12.5 1.1e-08 35.5 8.6 2.6 2 1 0 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 SF3b1 PF08920.5 ESL09798.1 - 1.8e-07 31.2 0.2 1.6e-06 28.2 0.1 2.3 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT PF02985.17 ESL09798.1 - 0.0023 17.8 11.9 20 5.6 0.1 8.0 8 1 0 8 8 8 0 HEAT repeat MMS19_C PF12460.3 ESL09798.1 - 0.0072 15.1 3.1 0.47 9.1 0.0 3.9 5 0 0 5 5 5 1 RNAPII transcription regulator C-terminal Adaptin_N PF01602.15 ESL09798.1 - 0.016 13.5 3.8 0.33 9.2 0.6 3.2 2 1 1 3 3 3 0 Adaptin N terminal region Arm PF00514.18 ESL09798.1 - 0.27 11.1 1.5 4.1 7.3 0.0 3.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat IQ PF00612.22 ESL09799.1 - 0.073 12.7 33.8 0.61 9.8 2.6 7.0 6 0 0 6 6 6 0 IQ calmodulin-binding motif ATG16 PF08614.6 ESL09801.1 - 0.00031 20.6 10.5 0.00031 20.6 7.3 2.6 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) CagE_TrbE_VirB PF03135.9 ESL09801.1 - 0.038 13.7 0.4 0.092 12.4 0.2 1.7 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system APG6 PF04111.7 ESL09801.1 - 0.45 9.5 21.7 1 8.3 7.1 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 Snf7 PF03357.16 ESL09801.1 - 0.49 9.7 17.5 0.017 14.5 7.2 2.2 2 0 0 2 2 2 0 Snf7 Microtub_assoc PF07989.6 ESL09801.1 - 0.51 10.1 12.9 0.45 10.3 0.9 3.6 3 0 0 3 3 3 0 Microtubule associated DUF342 PF03961.8 ESL09801.1 - 0.75 8.1 11.6 4 5.7 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) CorA PF01544.13 ESL09801.1 - 2.2 7.2 6.9 1.1 8.2 1.8 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Nucleoside_tran PF01733.13 ESL09802.1 - 1.1e-30 106.9 0.8 1.1e-30 106.9 0.6 2.0 2 1 0 2 2 2 1 Nucleoside transporter Vma12 PF11712.3 ESL09802.1 - 0.14 11.8 2.6 2.4 7.8 0.2 2.8 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Adap_comp_sub PF00928.16 ESL09804.1 - 1.1e-57 195.1 0.0 1.3e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESL09804.1 - 0.033 13.9 0.3 0.058 13.1 0.2 1.5 1 0 0 1 1 1 0 Clathrin adaptor complex small chain PK PF00224.16 ESL09806.1 - 8.3e-164 544.2 2.6 1.1e-163 543.8 1.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 ESL09806.1 - 1.4e-25 89.0 1.6 3.4e-25 87.8 0.0 2.5 4 0 0 4 4 4 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 ESL09806.1 - 5.2e-06 25.4 1.5 1.9e-05 23.6 0.6 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.20 ESL09806.1 - 0.36 9.6 8.8 0.44 9.3 0.0 3.1 2 1 1 3 3 3 0 IMP dehydrogenase / GMP reductase domain Spc97_Spc98 PF04130.8 ESL09807.1 - 2.4e-38 131.8 0.0 1.6e-19 69.6 0.0 2.8 2 1 0 2 2 2 2 Spc97 / Spc98 family PIP5K PF01504.13 ESL09809.1 - 7.8e-69 231.5 0.0 1.1e-68 231.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Fe-S_biosyn PF01521.15 ESL09810.1 - 1.5e-11 44.1 0.0 2.4e-09 37.1 0.0 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis WHIM2 PF15613.1 ESL09812.1 - 0.0009 19.0 0.0 0.0027 17.5 0.0 1.8 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 WHIM1 PF15612.1 ESL09812.1 - 0.002 17.9 0.2 0.0057 16.5 0.2 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Daxx PF03344.10 ESL09812.1 - 0.002 16.6 21.6 0.002 16.6 15.0 1.6 2 0 0 2 2 2 1 Daxx Family DDT PF02791.12 ESL09812.1 - 0.0098 15.6 0.0 0.03 14.0 0.0 1.9 1 0 0 1 1 1 1 DDT domain WHIM3 PF15614.1 ESL09812.1 - 0.037 13.7 0.0 0.13 12.0 0.0 2.2 2 1 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 3 RNA_pol_Rpb6 PF01192.17 ESL09813.1 - 1.5e-06 27.8 0.1 2.1e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 Nup84_Nup100 PF04121.8 ESL09814.1 - 2.4e-07 28.8 1.0 0.0024 15.6 0.1 2.3 1 1 1 2 2 2 2 Nuclear pore protein 84 / 107 Imm29 PF15575.1 ESL09814.1 - 0.01 15.4 0.8 0.12 11.9 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 29 polyprenyl_synt PF00348.12 ESL09815.1 - 2.8e-53 180.4 0.1 3.9e-53 179.9 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.14 ESL09815.1 - 5.7e-06 25.8 2.5 1.1e-05 24.8 1.7 1.4 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF2062 PF09835.4 ESL09816.1 - 1.5 8.3 5.9 2.1 7.9 4.1 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) PROCN PF08083.6 ESL09818.1 - 3.7e-158 526.2 10.5 5.9e-158 525.6 7.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 ESL09818.1 - 5.5e-91 304.0 0.0 8.6e-91 303.3 0.0 1.3 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 ESL09818.1 - 1e-67 226.4 0.0 2.2e-67 225.4 0.0 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.4 ESL09818.1 - 7.2e-55 184.3 0.0 1.9e-54 182.9 0.0 1.8 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.4 ESL09818.1 - 7.4e-36 121.8 0.0 2e-35 120.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 Big_2 PF02368.13 ESL09818.1 - 0.063 13.1 0.3 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) MCR_alpha PF02249.12 ESL09819.1 - 0.086 12.8 0.1 0.089 12.8 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain TAA-Trp-ring PF15401.1 ESL09819.1 - 0.088 13.0 0.3 0.95 9.7 0.1 2.0 1 1 1 2 2 2 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin PYNP_C PF07831.8 ESL09819.1 - 0.089 12.2 0.0 0.14 11.5 0.0 1.4 1 1 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain Ank PF00023.25 ESL09820.1 - 3.9e-35 117.9 1.6 7.4e-08 31.8 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 ESL09820.1 - 3.6e-31 107.3 2.8 1.8e-18 66.6 0.2 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL09820.1 - 7.5e-24 83.6 0.8 6.4e-06 26.5 0.0 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL09820.1 - 9.7e-24 81.0 1.2 2.8e-06 27.0 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 ESL09820.1 - 4.8e-23 80.6 4.6 1.5e-08 34.6 0.2 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) TPR_11 PF13414.1 ESL09821.1 - 5.7e-36 121.9 23.7 1.2e-15 56.8 1.7 5.4 4 2 2 6 6 6 5 TPR repeat TPR_1 PF00515.23 ESL09821.1 - 3.3e-22 77.0 24.0 1.7e-07 30.5 0.1 7.5 8 0 0 8 8 7 5 Tetratricopeptide repeat DnaJ PF00226.26 ESL09821.1 - 8.2e-20 70.3 0.1 2.1e-19 69.0 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 ESL09821.1 - 3.3e-17 60.9 29.8 0.00036 20.2 0.1 8.7 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09821.1 - 3.9e-14 52.8 14.6 0.00057 20.4 0.1 6.4 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESL09821.1 - 5.1e-11 42.7 10.2 0.046 14.0 0.0 6.1 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESL09821.1 - 2.8e-09 36.4 4.5 0.26 11.5 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09821.1 - 5.3e-09 35.9 12.6 1.3 9.8 0.0 7.7 4 2 4 8 8 8 3 Tetratricopeptide repeat Rapsyn_N PF10579.4 ESL09821.1 - 9.7e-07 28.5 0.7 1e-05 25.2 0.1 2.8 2 1 1 3 3 3 1 Rapsyn N-terminal myristoylation and linker region TPR_12 PF13424.1 ESL09821.1 - 1.6e-05 24.7 19.2 0.00029 20.6 0.4 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09821.1 - 2e-05 24.0 11.4 0.12 12.2 0.0 6.5 8 0 0 8 8 8 2 Tetratricopeptide repeat MIT PF04212.13 ESL09821.1 - 0.00039 20.2 6.6 5 7.0 0.9 5.3 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain Apc3 PF12895.2 ESL09821.1 - 0.00047 20.2 21.7 0.0037 17.3 0.2 5.1 4 3 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESL09821.1 - 0.035 13.9 11.4 0.85 9.5 0.1 5.2 5 1 2 7 7 6 0 Tetratricopeptide repeat NUP50 PF08911.6 ESL09821.1 - 0.045 14.1 0.7 0.52 10.7 0.1 2.7 1 1 1 2 2 2 0 NUP50 (Nucleoporin 50 kDa) TPR_7 PF13176.1 ESL09821.1 - 0.063 13.1 6.0 29 4.7 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C3HC4_2 PF13923.1 ESL09821.1 - 0.23 11.4 1.3 0.68 10.0 0.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_6 PF13174.1 ESL09821.1 - 0.63 10.6 21.3 4.7 7.8 0.1 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat CENP-F_leu_zip PF10473.4 ESL09822.1 - 0.048 13.5 1.9 0.12 12.1 1.3 1.7 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-Q PF13094.1 ESL09822.1 - 0.22 11.5 5.1 0.078 13.0 0.7 2.3 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DNA_pol_B_palm PF14792.1 ESL09823.1 - 3.5e-24 85.0 0.0 8e-24 83.8 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 ESL09823.1 - 4.9e-20 70.9 0.3 2.1e-10 40.1 0.0 2.7 2 0 0 2 2 2 2 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 ESL09823.1 - 1.1e-11 44.0 0.2 3.9e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 ESL09823.1 - 2.6e-05 24.3 2.6 0.007 16.5 1.0 3.4 2 1 0 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.1 ESL09823.1 - 0.00073 19.6 0.5 0.0028 17.7 0.0 2.3 3 0 0 3 3 3 1 Helix-hairpin-helix domain WD40 PF00400.27 ESL09824.1 - 6.1e-10 38.5 10.9 3.9e-08 32.8 0.3 5.8 6 0 0 6 6 6 1 WD domain, G-beta repeat uDENN PF03456.13 ESL09824.1 - 0.055 13.4 2.0 0.11 12.4 0.6 2.2 2 1 0 2 2 2 0 uDENN domain IKI3 PF04762.7 ESL09824.1 - 0.14 9.8 0.0 3 5.5 0.0 2.1 2 0 0 2 2 2 0 IKI3 family SBP_bac_3 PF00497.15 ESL09826.1 - 0.22 10.7 0.5 0.73 9.0 0.1 1.9 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 APG6 PF04111.7 ESL09827.1 - 1.6 7.7 7.4 0.81 8.6 3.6 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 IncA PF04156.9 ESL09827.1 - 2.1 7.9 6.9 3.2 7.3 4.8 1.3 1 0 0 1 1 1 0 IncA protein Glyco_hydro_65m PF03632.10 ESL09829.1 - 8.5e-40 136.5 0.0 1.2e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain HAD_2 PF13419.1 ESL09829.1 - 1e-05 25.8 0.0 2.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Glyco_hydro_65C PF03633.10 ESL09829.1 - 0.0036 17.3 0.0 0.0082 16.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain Cas_Cas02710 PF09670.5 ESL09829.1 - 0.018 13.7 0.0 0.036 12.7 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) MASE2 PF05230.6 ESL09829.1 - 0.091 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 MASE2 domain Ank_2 PF12796.2 ESL09830.1 - 4e-36 123.2 4.3 2e-11 44.0 0.2 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESL09830.1 - 5.6e-35 117.4 4.5 2.6e-08 33.2 0.0 6.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 ESL09830.1 - 5.1e-32 109.6 2.7 1.5e-09 38.1 0.0 5.1 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL09830.1 - 5.5e-27 93.1 9.6 4e-07 30.0 0.1 6.5 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL09830.1 - 1e-25 87.1 1.6 2.1e-05 24.3 0.0 6.9 7 0 0 7 7 7 5 Ankyrin repeat PI3_PI4_kinase PF00454.22 ESL09831.1 - 7e-31 107.5 0.1 2.2e-29 102.6 0.0 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 ESL09831.1 - 1.2e-09 37.6 0.0 2.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PseudoU_synth_2 PF00849.17 ESL09832.1 - 3.3e-23 82.3 0.0 9.1e-23 80.8 0.0 1.7 2 0 0 2 2 2 1 RNA pseudouridylate synthase DUF412 PF04217.8 ESL09832.1 - 0.047 13.4 0.1 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF412 ECH PF00378.15 ESL09833.1 - 1.5e-37 129.0 0.0 1.9e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Memo PF01875.12 ESL09834.1 - 6.3e-73 245.0 0.0 7.4e-73 244.8 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Carboxyl_trans PF01039.17 ESL09836.1 - 2.9e-32 111.6 0.0 3.5e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Ldh_1_N PF00056.18 ESL09837.1 - 3.2e-44 150.1 0.0 4.8e-44 149.6 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 ESL09837.1 - 3.7e-41 140.7 0.0 5.1e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain NAD_binding_10 PF13460.1 ESL09837.1 - 0.00045 20.2 0.0 0.00083 19.4 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESL09837.1 - 0.0012 17.5 0.0 0.0018 17.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 ESL09837.1 - 0.0014 18.5 0.0 0.0054 16.6 0.0 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.19 ESL09837.1 - 0.0046 17.2 0.1 0.012 15.9 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Acetyltransf_1 PF00583.19 ESL09838.1 - 3.3e-14 52.6 0.0 6.5e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL09838.1 - 4.4e-10 39.5 0.0 0.00026 21.1 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESL09838.1 - 4e-09 36.6 0.1 0.00039 20.5 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL09838.1 - 0.0046 16.8 0.1 0.062 13.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 ESL09838.1 - 0.013 15.4 0.0 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Nucleoporin_N PF08801.6 ESL09839.1 - 8.6e-54 182.8 0.3 1.4e-53 182.1 0.0 1.5 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.9 ESL09839.1 - 5.6e-12 44.9 8.3 3.1e-11 42.5 5.8 2.0 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Reo_sigmaC PF04582.7 ESL09840.1 - 0.00018 20.8 1.9 0.00018 20.8 1.3 2.5 1 1 2 3 3 3 1 Reovirus sigma C capsid protein DUF4200 PF13863.1 ESL09840.1 - 0.021 14.7 1.5 0.021 14.7 1.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) APG6 PF04111.7 ESL09840.1 - 0.088 11.8 24.8 0.032 13.3 4.1 2.3 1 1 1 2 2 2 0 Autophagy protein Apg6 HALZ PF02183.13 ESL09840.1 - 0.1 12.3 12.6 0.16 11.6 0.3 3.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper IncA PF04156.9 ESL09840.1 - 0.11 12.1 29.7 0.02 14.4 3.9 3.2 1 1 2 3 3 3 0 IncA protein DivIC PF04977.10 ESL09840.1 - 1.7 8.1 18.1 3.5 7.1 0.1 4.7 3 1 2 5 5 5 0 Septum formation initiator KLRAQ PF10205.4 ESL09840.1 - 1.9 8.5 17.4 0.094 12.7 2.4 3.6 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein ERM PF00769.14 ESL09840.1 - 2.5 7.5 31.9 4.7 6.6 7.3 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF3450 PF11932.3 ESL09840.1 - 4.1 6.5 22.4 0.043 13.0 2.9 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) ATG16 PF08614.6 ESL09840.1 - 4.1 7.1 28.9 1.3 8.7 7.1 3.2 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) Prefoldin PF02996.12 ESL09840.1 - 5.4 6.6 22.3 1.9 8.1 0.5 4.2 3 1 0 3 3 3 0 Prefoldin subunit CENP-F_leu_zip PF10473.4 ESL09840.1 - 6.3 6.6 30.4 0.67 9.8 7.5 2.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Actin PF00022.14 ESL09841.1 - 9.5e-65 218.5 0.0 1.1e-64 218.3 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ESL09841.1 - 0.0012 19.2 0.1 0.029 14.7 0.0 2.1 1 1 1 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) WD40 PF00400.27 ESL09842.1 - 7.6e-35 117.5 14.6 1.9e-07 30.7 0.4 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESL09842.1 - 0.0069 15.8 0.0 7.2 6.2 0.0 3.5 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.1 ESL09842.1 - 0.11 12.8 0.2 35 4.8 0.0 2.9 2 0 0 2 2 2 0 PQQ-like domain DUF3481 PF11980.3 ESL09843.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) DUF3040 PF11239.3 ESL09843.1 - 0.064 13.3 2.2 0.071 13.1 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) TMEM154 PF15102.1 ESL09843.1 - 0.15 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Extensin_2 PF04554.8 ESL09843.1 - 4.7 7.1 15.6 22 5.0 10.8 1.9 1 1 0 1 1 1 0 Extensin-like region Ribosomal_S17e PF00833.13 ESL09844.1 - 1.1e-51 173.6 2.9 1.3e-51 173.5 2.0 1.0 1 0 0 1 1 1 1 Ribosomal S17 Sld5 PF05916.6 ESL09844.1 - 0.12 12.7 0.4 0.14 12.4 0.3 1.4 1 1 0 1 1 1 0 GINS complex protein Ribosomal_S28e PF01200.13 ESL09845.1 - 1.8e-30 104.4 2.9 2.2e-30 104.1 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e DUF2135 PF09906.4 ESL09845.1 - 0.015 15.2 0.1 0.024 14.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2135) XRN_N PF03159.13 ESL09846.1 - 1.9e-89 299.1 0.0 2.9e-89 298.5 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Got1 PF04178.7 ESL09847.1 - 4e-26 91.4 12.6 5.3e-26 91.0 8.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family V_ATPase_I PF01496.14 ESL09847.1 - 0.96 7.2 3.9 1.1 7.0 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AzlD PF05437.7 ESL09847.1 - 2.8 7.9 7.3 2.5 8.1 1.6 2.4 1 1 2 3 3 3 0 Branched-chain amino acid transport protein (AzlD) RRM_1 PF00076.17 ESL09848.1 - 7.5e-13 47.9 0.0 1.4e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL09848.1 - 1e-11 44.6 0.0 1.8e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL09848.1 - 5.1e-05 23.0 0.0 8.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HOOK PF05622.7 ESL09849.1 - 0.018 12.8 10.6 0.028 12.2 7.4 1.1 1 0 0 1 1 1 0 HOOK protein Apolipoprotein PF01442.13 ESL09850.1 - 0.00036 20.0 7.6 0.00077 19.0 1.5 2.5 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain HALZ PF02183.13 ESL09850.1 - 0.0035 17.0 0.5 0.19 11.4 0.1 2.7 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF1664 PF07889.7 ESL09850.1 - 0.0058 16.4 1.8 0.026 14.3 0.8 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Rep_trans PF02486.14 ESL09850.1 - 0.025 14.0 1.0 0.051 13.0 0.7 1.5 1 0 0 1 1 1 0 Replication initiation factor Syntaxin_2 PF14523.1 ESL09850.1 - 0.026 14.5 2.4 6.3 6.9 0.0 3.1 2 1 1 3 3 3 0 Syntaxin-like protein FlaC_arch PF05377.6 ESL09850.1 - 0.06 13.2 4.3 4.6 7.2 0.0 3.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Hemerythrin PF01814.18 ESL09850.1 - 0.074 13.2 2.4 0.65 10.1 0.2 2.9 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain Fib_alpha PF08702.5 ESL09850.1 - 0.096 12.8 3.3 0.34 11.0 0.1 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.7 ESL09850.1 - 0.19 11.5 2.0 0.81 9.4 0.2 2.7 2 1 1 3 3 3 0 Laminin Domain II Spc7 PF08317.6 ESL09850.1 - 1.2 7.7 11.2 0.028 13.0 1.2 2.5 3 1 0 3 3 3 0 Spc7 kinetochore protein DUF972 PF06156.8 ESL09850.1 - 1.6 9.1 7.6 0.34 11.2 0.3 3.3 3 2 1 4 4 4 0 Protein of unknown function (DUF972) TBPIP PF07106.8 ESL09850.1 - 2.3 7.7 10.2 0.25 10.8 0.6 3.4 3 2 1 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) cNMP_binding PF00027.24 ESL09851.1 - 8.2e-24 83.2 0.2 7.9e-11 41.6 0.1 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Rer1 PF03248.8 ESL09853.1 - 6.6e-43 146.3 2.2 7.5e-43 146.1 1.5 1.0 1 0 0 1 1 1 1 Rer1 family Peptidase_M8 PF01457.11 ESL09858.1 - 7.1e-25 87.3 1.5 8.1e-25 87.1 1.0 1.0 1 0 0 1 1 1 1 Leishmanolysin DUF1049 PF06305.6 ESL09858.1 - 0.32 10.4 2.0 0.48 9.9 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Mito_carr PF00153.22 ESL09859.1 - 7.4e-29 99.3 1.6 1.2e-13 50.5 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF676 PF05057.9 ESL09861.1 - 1.4e-19 70.2 0.0 3.6e-19 68.9 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.10 ESL09861.1 - 0.0012 17.8 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 ESL09861.1 - 0.012 15.5 0.0 0.026 14.3 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL09861.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.7 ESL09861.1 - 0.019 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.8 ESL09861.1 - 0.045 13.3 0.0 0.26 10.8 0.0 2.2 1 1 0 1 1 1 0 PGAP1-like protein Ax_dynein_light PF10211.4 ESL09862.1 - 6.7e-52 176.0 9.3 8e-52 175.8 6.4 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain bZIP_1 PF00170.16 ESL09862.1 - 0.00059 19.7 7.6 0.13 12.2 2.0 2.8 1 1 1 2 2 2 2 bZIP transcription factor Seryl_tRNA_N PF02403.17 ESL09862.1 - 0.001 19.0 8.1 0.002 18.0 5.6 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF4211 PF13926.1 ESL09862.1 - 0.0077 15.6 0.6 0.013 14.8 0.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4211) DUF4472 PF14739.1 ESL09862.1 - 0.017 15.5 6.1 0.032 14.6 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) Apt1 PF10351.4 ESL09862.1 - 0.068 12.0 5.5 0.082 11.7 3.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain APG6 PF04111.7 ESL09862.1 - 0.23 10.4 9.6 0.3 10.0 6.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 AKNA PF12443.3 ESL09862.1 - 0.24 11.4 3.4 0.16 12.0 0.2 2.4 3 1 0 3 3 3 0 AT-hook-containing transcription factor bZIP_2 PF07716.10 ESL09862.1 - 0.38 10.6 11.7 1.5 8.7 3.3 2.7 1 1 1 2 2 2 0 Basic region leucine zipper WD40_alt PF14077.1 ESL09862.1 - 0.43 10.2 3.0 0.79 9.3 0.1 2.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF4570 PF15134.1 ESL09862.1 - 0.55 10.1 8.8 0.27 11.1 4.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Spc24 PF08286.6 ESL09862.1 - 0.55 9.9 4.9 0.8 9.4 2.8 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF972 PF06156.8 ESL09862.1 - 7.9 6.8 8.5 10 6.5 4.8 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Kinesin PF00225.18 ESL09863.1 - 1.5e-104 349.3 0.0 2.5e-104 348.6 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Exonuc_VII_L PF02601.10 ESL09863.1 - 0.0056 15.9 2.7 0.0056 15.9 1.9 1.5 2 0 0 2 2 2 1 Exonuclease VII, large subunit DNA_pol_B_2 PF03175.8 ESL09863.1 - 0.01 14.5 0.1 0.018 13.7 0.1 1.3 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral V_ATPase_I PF01496.14 ESL09863.1 - 0.27 9.0 2.8 0.41 8.4 2.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3338 PF11819.3 ESL09863.1 - 0.33 10.4 6.2 0.69 9.3 1.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) P4Ha_N PF08336.6 ESL09863.1 - 0.35 10.7 7.2 0.32 10.8 3.3 2.2 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FUSC PF04632.7 ESL09863.1 - 0.45 8.8 3.5 0.74 8.1 2.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family SAM_2 PF07647.12 ESL09864.1 - 0.00054 19.7 0.0 0.00082 19.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 ESL09864.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain GRAM PF02893.15 ESL09865.1 - 9.5e-07 28.2 0.0 2.4e-06 26.9 0.0 1.7 1 1 0 1 1 1 1 GRAM domain Acetyltransf_1 PF00583.19 ESL09867.1 - 2.7e-13 49.7 0.0 4.8e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL09867.1 - 3.8e-06 26.9 0.0 6.9e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL09867.1 - 0.00026 20.6 0.0 0.00047 19.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 ESL09867.1 - 0.002 18.2 0.0 0.0048 16.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESL09867.1 - 0.006 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL09867.1 - 0.026 14.3 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LicD PF04991.8 ESL09868.1 - 7.2e-12 45.8 0.2 3e-11 43.8 0.0 2.0 3 0 0 3 3 3 1 LicD family AAA PF00004.24 ESL09869.1 - 1.3e-29 103.1 0.1 4.1e-18 65.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL09869.1 - 1.9e-10 40.9 0.3 0.00022 21.3 0.0 4.2 3 1 1 4 4 3 2 AAA domain Zot PF05707.7 ESL09869.1 - 4.6e-09 36.0 1.5 0.0002 20.9 0.1 4.0 2 2 0 3 3 3 2 Zonular occludens toxin (Zot) AAA_16 PF13191.1 ESL09869.1 - 1.3e-08 35.0 0.1 5.4e-05 23.2 0.0 3.5 2 1 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 ESL09869.1 - 1.2e-07 31.7 0.0 1.6e-05 24.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESL09869.1 - 9e-07 28.4 0.1 0.02 14.2 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL09869.1 - 1.2e-06 28.6 0.0 0.019 15.1 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.1 ESL09869.1 - 6.5e-06 25.6 3.6 0.016 14.6 0.0 3.4 4 0 0 4 4 4 2 AAA domain AAA_10 PF12846.2 ESL09869.1 - 2.6e-05 23.8 2.6 0.12 11.7 0.1 4.0 2 2 1 4 4 4 1 AAA-like domain AAA_17 PF13207.1 ESL09869.1 - 3e-05 24.8 0.0 0.045 14.5 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.1 ESL09869.1 - 3.8e-05 23.5 0.0 0.15 11.9 0.0 3.1 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 ESL09869.1 - 0.0001 22.0 0.1 0.11 12.1 0.0 3.3 3 0 0 3 3 3 1 Archaeal ATPase AAA_5 PF07728.9 ESL09869.1 - 0.0002 21.1 0.1 0.032 13.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESL09869.1 - 0.0002 21.6 2.3 0.0034 17.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.1 ESL09869.1 - 0.00031 21.1 0.1 0.21 11.8 0.1 2.7 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESL09869.1 - 0.00036 19.3 0.2 0.028 13.1 0.0 2.6 3 0 0 3 3 3 1 TIP49 C-terminus ABC_tran PF00005.22 ESL09869.1 - 0.00045 20.5 0.0 0.26 11.5 0.0 2.8 2 0 0 2 2 2 1 ABC transporter RuvB_N PF05496.7 ESL09869.1 - 0.00048 19.2 0.1 0.076 12.0 0.0 2.9 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus PhoH PF02562.11 ESL09869.1 - 0.00077 18.7 0.4 0.1 11.7 0.0 3.2 2 1 1 3 3 3 1 PhoH-like protein NACHT PF05729.7 ESL09869.1 - 0.0017 18.0 0.0 0.089 12.4 0.0 2.7 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.16 ESL09869.1 - 0.0019 17.4 0.1 0.2 10.7 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESL09869.1 - 0.0021 17.5 0.0 0.71 9.3 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_29 PF13555.1 ESL09869.1 - 0.0027 17.2 0.4 2.6 7.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF2075 PF09848.4 ESL09869.1 - 0.0031 16.5 0.1 1.9 7.3 0.0 3.1 2 1 1 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.9 ESL09869.1 - 0.004 17.0 0.0 0.3 10.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.1 ESL09869.1 - 0.0072 15.9 0.5 0.46 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 ESL09869.1 - 0.0099 14.8 0.0 1.7 7.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) T2SE PF00437.15 ESL09869.1 - 0.014 14.3 0.0 0.059 12.2 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF258 PF03193.11 ESL09869.1 - 0.019 14.1 0.0 0.53 9.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 APS_kinase PF01583.15 ESL09869.1 - 0.041 13.5 0.1 0.25 11.0 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase PEPCK_ATP PF01293.15 ESL09869.1 - 0.06 11.8 0.5 0.4 9.1 0.1 2.1 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase PIF1 PF05970.9 ESL09869.1 - 0.062 12.2 0.2 0.53 9.1 0.1 2.1 2 0 0 2 2 2 0 PIF1-like helicase AAA_28 PF13521.1 ESL09869.1 - 0.062 13.2 0.1 1.7 8.6 0.0 2.8 2 1 0 3 3 2 0 AAA domain ResIII PF04851.10 ESL09869.1 - 0.068 12.9 0.1 2 8.1 0.1 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit IPT PF01745.11 ESL09869.1 - 0.076 12.1 0.0 6.3 5.9 0.0 2.5 2 0 0 2 2 2 0 Isopentenyl transferase MobB PF03205.9 ESL09869.1 - 0.085 12.5 0.0 0.9 9.2 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Parvo_NS1 PF01057.12 ESL09869.1 - 0.1 11.4 0.0 0.97 8.2 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ATP-synt_ab PF00006.20 ESL09869.1 - 0.13 11.7 0.0 2.5 7.5 0.0 2.5 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain KAP_NTPase PF07693.9 ESL09869.1 - 0.13 11.1 0.0 0.28 10.1 0.0 1.5 1 0 0 1 1 1 0 KAP family P-loop domain DnaJ PF00226.26 ESL09870.1 - 7.6e-17 60.8 0.1 7.6e-17 60.8 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain CIAPIN1 PF05093.8 ESL09870.1 - 0.042 13.9 2.7 0.11 12.6 0.3 2.3 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis TauD PF02668.11 ESL09870.1 - 0.047 13.3 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family TP6A_N PF04406.9 ESL09871.1 - 6.2e-08 32.1 0.0 1.1e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.5 ESL09871.1 - 0.063 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) PRP4 PF08799.6 ESL09871.1 - 0.12 11.6 1.4 0.29 10.4 0.9 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Peptidase_M20 PF01546.23 ESL09872.1 - 1.6e-20 73.3 0.2 1.9e-20 73.1 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL09872.1 - 3.8e-09 36.2 0.0 8.3e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 ESL09872.1 - 0.0054 16.4 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 Radial_spoke PF04712.7 ESL09873.1 - 2.8e-06 26.3 17.6 0.0001 21.2 0.0 2.9 2 1 0 2 2 2 1 Radial spokehead-like protein TRAP_alpha PF03896.11 ESL09873.1 - 0.00015 20.8 0.7 0.00019 20.5 0.5 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit PBP1_TM PF14812.1 ESL09873.1 - 0.018 15.3 5.3 0.03 14.6 3.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spore_coat_CotO PF14153.1 ESL09873.1 - 0.025 13.9 5.9 0.038 13.4 4.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Inhibitor_I71 PF12628.2 ESL09873.1 - 0.084 12.5 0.1 0.22 11.1 0.0 1.7 1 1 1 2 2 2 0 Falstatin, cysteine peptidase inhibitor Tim54 PF11711.3 ESL09873.1 - 0.2 10.2 4.6 0.26 9.8 3.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TLP-20 PF06088.6 ESL09873.1 - 0.57 9.8 5.3 3.3 7.3 3.8 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Pox_Ag35 PF03286.9 ESL09873.1 - 0.57 9.6 4.3 0.77 9.2 3.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sporozoite_P67 PF05642.6 ESL09873.1 - 0.68 7.7 5.2 0.91 7.3 3.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.6 ESL09873.1 - 0.75 7.8 4.1 0.94 7.5 2.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nucleoplasmin PF03066.10 ESL09873.1 - 0.84 9.1 18.6 1.3 8.5 12.9 1.2 1 0 0 1 1 1 0 Nucleoplasmin Prothymosin PF03247.9 ESL09873.1 - 1.3 9.2 24.6 1.9 8.6 17.0 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family Nop14 PF04147.7 ESL09873.1 - 1.4 6.7 14.0 1.8 6.3 9.7 1.0 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.5 ESL09873.1 - 1.6 8.9 16.7 2.9 8.1 11.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 ESL09873.1 - 2 7.9 12.6 2.9 7.4 8.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region HSP90 PF00183.13 ESL09873.1 - 3.3 5.9 12.9 4.6 5.5 9.0 1.1 1 0 0 1 1 1 0 Hsp90 protein YqfQ PF14181.1 ESL09873.1 - 5.7 6.9 6.4 8.9 6.3 4.4 1.2 1 0 0 1 1 1 0 YqfQ-like protein NOA36 PF06524.7 ESL09873.1 - 7 5.8 10.8 10 5.2 7.5 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2890 PF11081.3 ESL09873.1 - 8.9 6.3 13.8 14 5.7 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) VID27 PF08553.5 ESL09873.1 - 9 4.3 11.6 12 3.9 8.0 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein DUF3381 PF11861.3 ESL09873.1 - 9.6 5.6 13.5 15 5.0 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) WD40 PF00400.27 ESL09874.1 - 1.1e-11 44.0 22.6 2.2e-06 27.3 1.3 6.3 6 1 0 6 6 6 4 WD domain, G-beta repeat NAD_binding_8 PF13450.1 ESL09875.1 - 0.0048 16.8 0.1 0.017 15.0 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 ESL09875.1 - 0.013 14.5 0.2 0.083 11.9 0.2 1.9 1 1 0 1 1 1 0 FAD binding domain DAO PF01266.19 ESL09875.1 - 0.088 11.6 0.0 0.16 10.8 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.12 ESL09875.1 - 0.12 11.4 0.0 0.24 10.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Galactosyl_T PF01762.16 ESL09876.1 - 0.1 12.2 0.0 1.8 8.0 0.0 2.0 1 1 1 2 2 2 0 Galactosyltransferase RNA_pol_Rpb1_5 PF04998.12 ESL09877.1 - 6.7e-84 281.4 0.0 2.5e-83 279.5 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ESL09877.1 - 2e-63 213.2 0.0 3.5e-63 212.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.7 ESL09877.1 - 4.3e-55 187.3 0.0 7.9e-55 186.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.13 ESL09877.1 - 4.7e-32 110.9 0.0 1e-31 109.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESL09877.1 - 5.3e-32 109.7 0.0 1.3e-31 108.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 PLAC8 PF04749.12 ESL09878.1 - 0.00025 21.5 10.9 0.00095 19.7 7.6 1.9 1 1 0 1 1 1 1 PLAC8 family DUF4140 PF13600.1 ESL09879.1 - 0.43 11.0 8.0 2.2 8.7 0.2 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) SlyX PF04102.7 ESL09879.1 - 0.76 10.1 6.3 3 8.2 0.4 2.4 2 1 0 2 2 2 0 SlyX ParA PF10609.4 ESL09880.1 - 1.5e-36 124.1 0.1 2.6e-36 123.3 0.1 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESL09880.1 - 7.6e-17 61.3 0.0 1.2e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.10 ESL09880.1 - 8.1e-07 28.3 0.1 3.9e-05 22.8 0.1 2.8 3 0 0 3 3 3 1 Anion-transporting ATPase MipZ PF09140.6 ESL09880.1 - 9.6e-07 28.1 0.1 6.6e-05 22.1 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.1 ESL09880.1 - 5e-05 23.2 0.0 0.00023 21.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESL09880.1 - 0.00021 20.7 0.1 0.00035 20.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL09880.1 - 0.00089 18.9 0.1 0.24 11.1 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain Fer4_NifH PF00142.13 ESL09880.1 - 0.0061 15.7 0.0 0.015 14.5 0.1 1.6 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArgK PF03308.11 ESL09880.1 - 0.0097 14.7 0.1 0.014 14.1 0.1 1.2 1 0 0 1 1 1 1 ArgK protein IstB_IS21 PF01695.12 ESL09880.1 - 0.034 13.5 0.1 0.073 12.4 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_26 PF13500.1 ESL09880.1 - 0.052 13.1 0.0 0.46 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 ESL09880.1 - 0.062 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase NACHT PF05729.7 ESL09880.1 - 0.065 12.8 0.7 0.11 12.1 0.5 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 ESL09880.1 - 0.087 13.0 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.17 ESL09880.1 - 0.088 11.6 0.1 0.15 10.8 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain DUF258 PF03193.11 ESL09880.1 - 0.088 11.9 0.2 0.17 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Zn_Tnp_IS1595 PF12760.2 ESL09880.1 - 0.098 12.4 0.4 0.23 11.2 0.3 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain SRP54 PF00448.17 ESL09880.1 - 0.1 12.0 0.1 0.5 9.7 0.1 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MFS_1 PF07690.11 ESL09881.1 - 1.1e-21 76.9 37.1 1.9e-12 46.5 16.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MA3 PF02847.12 ESL09882.1 - 7.8e-11 41.6 0.7 7.8e-11 41.6 0.5 2.1 3 0 0 3 3 3 1 MA3 domain MIF4G PF02854.14 ESL09882.1 - 8.2e-07 28.6 0.0 1.4e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 MIF4G domain B1 PF02246.10 ESL09882.1 - 0.015 15.1 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 Protein L b1 domain CAS_CSE1 PF03378.10 ESL09882.1 - 0.099 10.9 0.0 0.17 10.1 0.0 1.3 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus DUF3144 PF11342.3 ESL09882.1 - 0.1 12.6 4.0 7 6.8 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3144) Ribosomal_L29e PF01779.12 ESL09883.1 - 6.4e-18 64.3 7.9 1.2e-17 63.4 5.5 1.5 1 0 0 1 1 1 1 Ribosomal L29e protein family EF-1_beta_acid PF10587.4 ESL09883.1 - 1.7 8.8 5.0 2.7 8.2 3.4 1.3 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Adaptin_N PF01602.15 ESL09884.1 - 5.6e-55 186.6 0.0 6.8e-55 186.3 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.17 ESL09884.1 - 0.0094 15.9 3.1 4.4 7.6 0.0 3.9 3 1 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.1 ESL09884.1 - 0.011 15.9 0.2 0.13 12.5 0.0 2.8 2 1 1 3 3 3 0 HEAT repeats HEAT_EZ PF13513.1 ESL09884.1 - 0.013 16.0 0.8 2.2 8.8 0.0 3.8 4 0 0 4 4 4 0 HEAT-like repeat Cnd1 PF12717.2 ESL09884.1 - 0.017 14.9 0.0 0.13 12.0 0.0 2.4 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Glyco_hydro_66 PF13199.1 ESL09884.1 - 0.15 10.4 0.0 0.25 9.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Carboxyl_trans PF01039.17 ESL09885.1 - 1.5e-125 419.4 0.0 2.3e-125 418.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.7 ESL09885.1 - 4.1e-67 226.8 0.0 6.4e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region TPR_11 PF13414.1 ESL09886.1 - 1.7e-13 49.9 15.0 1.8e-09 37.0 0.1 5.1 3 1 1 4 4 4 3 TPR repeat TPR_17 PF13431.1 ESL09886.1 - 1.2e-09 37.5 0.8 0.00012 21.9 0.2 4.6 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL09886.1 - 1.4e-08 34.0 17.0 0.012 15.5 0.0 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09886.1 - 2.5e-08 33.8 17.3 0.14 12.8 0.0 6.7 5 2 2 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09886.1 - 9.3e-07 28.2 10.2 0.2 11.3 0.0 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL09886.1 - 8.3e-05 22.0 5.9 5.5 7.0 0.0 6.4 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL09886.1 - 0.0014 18.4 12.3 0.48 10.4 0.0 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL09886.1 - 0.0015 18.8 10.4 0.21 11.9 0.0 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL09886.1 - 0.002 18.7 2.5 0.029 15.0 0.1 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat OGG_N PF07934.7 ESL09886.1 - 0.012 15.6 0.2 1.5 8.8 0.1 3.3 2 1 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain Clathrin PF00637.15 ESL09886.1 - 0.071 12.6 2.4 0.17 11.4 0.3 2.5 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_7 PF13176.1 ESL09886.1 - 4.1 7.4 13.3 10 6.2 0.0 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat BBS1 PF14779.1 ESL09887.1 - 4.2e-60 202.8 0.0 7e-60 202.1 0.0 1.3 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 1 BBS2_Mid PF14783.1 ESL09887.1 - 3.3e-06 26.8 0.0 0.36 10.6 0.0 3.4 2 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF3356 PF11836.3 ESL09887.1 - 0.021 14.6 0.0 0.05 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3356) PHTB1_N PF14727.1 ESL09887.1 - 0.045 12.7 0.0 0.2 10.5 0.0 2.0 2 0 0 2 2 2 0 PTHB1 N-terminus Sec20 PF03908.8 ESL09888.1 - 7.7e-05 22.3 0.9 0.00026 20.6 0.0 2.2 2 1 1 3 3 3 1 Sec20 V-SNARE_C PF12352.3 ESL09888.1 - 0.015 15.3 0.8 0.036 14.1 0.6 1.5 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Sigma70_r4_2 PF08281.7 ESL09888.1 - 0.046 13.1 0.3 0.11 11.9 0.2 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 Acyl-CoA_dh_C PF12806.2 ESL09888.1 - 0.052 13.4 2.1 0.42 10.4 0.0 2.4 2 1 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like DUF552 PF04472.7 ESL09888.1 - 0.12 12.2 0.7 10 6.1 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF552) CcmD PF04995.9 ESL09888.1 - 0.17 11.6 2.2 0.36 10.5 0.2 2.6 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) LXG PF04740.7 ESL09888.1 - 0.2 11.4 2.0 0.51 10.0 0.2 2.0 2 0 0 2 2 2 0 LXG domain of WXG superfamily TroA PF01297.12 ESL09888.1 - 0.69 9.1 0.0 0.69 9.1 0.0 2.5 2 1 1 3 3 3 0 Periplasmic solute binding protein family IATP PF04568.7 ESL09888.1 - 1.2 9.1 6.0 1.2 9.1 2.8 2.1 1 1 1 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Troponin PF00992.15 ESL09888.1 - 1.6 8.8 9.3 0.29 11.1 1.3 2.3 2 0 0 2 2 2 0 Troponin HAUS-augmin3 PF14932.1 ESL09888.1 - 1.7 7.7 8.8 0.72 8.9 0.8 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 EFP_N PF08207.7 ESL09890.1 - 8.2e-05 22.3 0.3 0.00014 21.6 0.2 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain UQ_con PF00179.21 ESL09891.1 - 1.3e-38 131.6 0.0 1.8e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Kinesin PF00225.18 ESL09893.1 - 4.6e-28 97.8 0.5 3.9e-22 78.4 0.0 3.2 3 0 0 3 3 3 2 Kinesin motor domain IFP_35_N PF07334.8 ESL09893.1 - 0.081 12.9 0.1 0.081 12.9 0.1 3.4 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF563 PF04577.9 ESL09894.1 - 3.8e-33 115.1 3.5 7.9e-33 114.1 2.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) HSCB_C PF07743.8 ESL09896.1 - 7.1e-09 36.0 0.5 7.1e-09 36.0 0.3 2.4 3 0 0 3 3 3 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 ESL09896.1 - 3.1e-07 30.0 0.7 3.6e-06 26.5 0.5 2.2 1 1 0 1 1 1 1 DnaJ domain Host_attach PF10116.4 ESL09896.1 - 0.013 15.7 2.2 0.019 15.2 0.5 2.2 2 1 0 2 2 2 0 Protein required for attachment to host cells Peptidase_S49_N PF08496.5 ESL09896.1 - 0.013 15.2 0.3 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4496 PF14908.1 ESL09897.1 - 1.2e-10 41.3 0.0 2.9e-10 40.1 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4496) Bac_DNA_binding PF00216.16 ESL09897.1 - 0.032 14.2 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial DNA-binding protein Voltage_CLC PF00654.15 ESL09902.1 - 5e-90 302.0 35.4 6.8e-90 301.6 22.6 2.0 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 ESL09902.1 - 2.2e-11 43.3 1.7 3.3e-05 23.5 0.1 3.5 3 0 0 3 3 3 2 CBS domain TAT_signal PF10518.4 ESL09902.1 - 0.011 15.7 0.1 0.011 15.7 0.1 4.1 5 0 0 5 5 5 0 TAT (twin-arginine translocation) pathway signal sequence Mito_carr PF00153.22 ESL09903.1 - 3.4e-57 190.1 1.2 2.6e-18 65.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein F-box-like PF12937.2 ESL09904.1 - 5e-05 22.9 0.4 0.00013 21.5 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESL09904.1 - 0.0099 15.5 0.1 0.03 13.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain Pkinase PF00069.20 ESL09905.1 - 2.9e-39 134.8 0.0 3.6e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09905.1 - 2.7e-24 85.6 0.0 3.3e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09905.1 - 4.7e-05 22.4 0.0 0.00042 19.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like GST_C_2 PF13410.1 ESL09906.1 - 0.014 15.2 0.3 0.14 12.0 0.1 2.3 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF2929 PF11151.3 ESL09906.1 - 0.019 15.0 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2929) Mic1 PF07035.7 ESL09907.1 - 1.4e-05 24.4 0.1 2.9e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Helicase_C PF00271.26 ESL09909.1 - 9.8e-05 22.1 0.0 0.00027 20.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL09909.1 - 0.00081 18.9 0.0 0.0019 17.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase APOC4 PF15119.1 ESL09909.1 - 0.039 13.9 0.0 0.45 10.5 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein C4 SNF2_N PF00176.18 ESL09911.1 - 1.3e-43 148.9 0.0 2.2e-43 148.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL09911.1 - 1.6e-09 37.4 0.0 3.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL09911.1 - 7.6e-05 22.6 0.0 0.00036 20.4 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 ESL09911.1 - 0.0003 20.3 0.0 0.0052 16.2 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase GCFC PF07842.7 ESL09911.1 - 0.18 11.1 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein TPR_19 PF14559.1 ESL09912.1 - 3.4e-17 62.5 17.1 3.1e-07 30.6 2.6 7.7 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESL09912.1 - 1.5e-11 43.7 19.8 0.014 15.0 0.3 6.9 8 0 0 8 8 8 4 TPR repeat Apc3 PF12895.2 ESL09912.1 - 7e-08 32.4 12.3 0.03 14.4 0.1 6.6 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ESL09912.1 - 1.6e-07 31.8 50.1 0.031 14.9 1.0 9.3 11 1 0 11 11 11 6 Tetratricopeptide repeat TPR_2 PF07719.12 ESL09912.1 - 3e-06 26.7 19.1 0.13 12.2 0.0 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL09912.1 - 0.0014 18.5 27.6 0.14 12.1 0.2 7.2 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL09912.1 - 0.0024 18.3 36.0 0.12 13.0 0.0 9.4 9 3 3 12 12 12 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESL09912.1 - 0.0029 17.1 7.8 0.067 12.8 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat RE_LlaJI PF09563.5 ESL09912.1 - 0.056 12.1 0.5 0.1 11.3 0.3 1.3 1 0 0 1 1 1 0 LlaJI restriction endonuclease Ribosomal_L32e PF01655.13 ESL09913.1 - 5.6e-42 142.2 0.8 6.6e-42 142.0 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 DUF1436 PF07262.6 ESL09913.1 - 0.082 12.3 0.1 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) Epimerase PF01370.16 ESL09915.1 - 5e-51 173.4 0.0 6.5e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 ESL09915.1 - 2.2e-05 24.2 0.0 5.5e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit zf-CHCC PF10276.4 ESL09916.1 - 0.0021 17.8 2.3 0.0021 17.8 1.6 2.2 3 0 0 3 3 3 1 Zinc-finger domain BK_channel_a PF03493.13 ESL09917.1 - 1.9e-20 72.6 0.0 3.8e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.11 ESL09917.1 - 3.6e-11 42.6 2.4 1.3e-10 40.8 1.7 2.1 1 0 0 1 1 1 1 Ion channel Lig_chan PF00060.21 ESL09917.1 - 0.78 9.4 3.7 1.8 8.3 2.6 1.5 1 0 0 1 1 1 0 Ligand-gated ion channel DUF2239 PF09998.4 ESL09918.1 - 0.027 14.0 0.3 0.048 13.2 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2239) eIF-3c_N PF05470.7 ESL09919.1 - 3e-27 94.9 19.7 3.7e-23 81.4 3.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 ESL09919.1 - 0.0041 17.4 0.1 0.024 14.9 0.0 2.5 2 0 0 2 2 2 1 PCI domain Sec62 PF03839.11 ESL09919.1 - 0.6 9.4 3.9 1.1 8.6 2.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 SNF2_N PF00176.18 ESL09920.1 - 2.1e-48 164.6 0.0 3.2e-48 164.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL09920.1 - 8.6e-14 51.1 0.0 2.4e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL09920.1 - 1.3e-06 28.0 0.0 2.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESL09920.1 - 2.6e-05 24.1 0.0 7e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PWWP PF00855.12 ESL09921.1 - 1.5e-09 37.9 0.2 3.9e-09 36.5 0.0 1.8 2 0 0 2 2 2 1 PWWP domain TFIIS_C PF01096.13 ESL09921.1 - 1.2e-05 24.8 0.6 4.1e-05 23.1 0.4 2.0 1 1 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 ESL09921.1 - 0.0014 18.0 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Lar_restr_allev PF14354.1 ESL09921.1 - 0.0016 18.6 0.3 0.0052 17.0 0.2 1.9 1 0 0 1 1 1 1 Restriction alleviation protein Lar zinc_ribbon_5 PF13719.1 ESL09921.1 - 0.0039 16.7 0.8 0.014 14.9 0.6 1.9 1 1 0 1 1 1 1 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 ESL09921.1 - 0.0085 15.3 0.2 0.022 14.0 0.2 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding zinc_ribbon_4 PF13717.1 ESL09921.1 - 0.018 14.7 1.3 0.066 12.9 0.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zf-DNL PF05180.7 ESL09921.1 - 0.1 12.3 0.3 0.23 11.1 0.2 1.6 1 0 0 1 1 1 0 DNL zinc finger zf-ribbon_3 PF13248.1 ESL09921.1 - 0.11 11.7 1.0 3.8 6.8 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain eIF-3_zeta PF05091.7 ESL09921.1 - 0.31 9.6 7.6 0.44 9.0 5.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SAPS PF04499.10 ESL09921.1 - 0.42 9.1 4.4 0.59 8.7 3.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cons_hypoth698 PF03601.9 ESL09923.1 - 0.0044 15.7 0.0 0.0066 15.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 698 Baculo_PEP_C PF04513.7 ESL09924.1 - 0.022 14.5 25.3 13 5.5 0.1 9.3 5 2 4 10 10 10 0 Baculovirus polyhedron envelope protein, PEP, C terminus YvrJ PF12841.2 ESL09924.1 - 0.077 12.2 1.4 21 4.4 0.0 3.9 2 0 0 2 2 2 0 YvrJ protein family Reo_sigmaC PF04582.7 ESL09924.1 - 0.51 9.4 34.3 1.8 7.6 0.2 7.9 3 2 6 10 10 10 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 ESL09924.1 - 3.2 8.0 26.3 1.6 9.0 0.1 9.6 8 3 1 9 9 9 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.6 ESL09924.1 - 9.7 6.6 48.6 0.64 10.4 0.1 10.1 7 3 6 13 13 13 0 Syntaxin 6, N-terminal MMgT PF10270.4 ESL09925.1 - 0.16 12.3 3.7 2.2 8.7 2.6 2.5 1 1 0 1 1 1 0 Membrane magnesium transporter DUF3043 PF11241.3 ESL09925.1 - 0.31 10.6 1.7 0.34 10.4 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) DUF443 PF04276.7 ESL09925.1 - 0.53 9.6 11.5 4.8 6.5 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF443) FUSC-like PF12805.2 ESL09925.1 - 0.86 8.4 5.8 1.1 8.0 4.0 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS HEAT_2 PF13646.1 ESL09926.1 - 0.03 14.5 1.6 3.3 8.0 0.1 2.4 2 0 0 2 2 2 0 HEAT repeats DUF445 PF04286.7 ESL09926.1 - 0.06 12.8 0.7 0.086 12.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Aminotran_5 PF00266.14 ESL09929.1 - 1.3e-53 182.1 0.0 3.6e-53 180.6 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V MFS_1 PF07690.11 ESL09930.1 - 1.2e-22 80.1 22.4 1.8e-16 59.8 14.9 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESL09930.1 - 6.6e-09 35.3 17.3 6.6e-09 35.3 12.0 2.5 2 1 0 2 2 2 1 Nodulin-like DUF3357 PF11837.3 ESL09930.1 - 0.82 9.5 6.2 23 4.9 0.4 4.4 3 1 2 5 5 5 0 Domain of unknown function (DUF3357) DUF3040 PF11239.3 ESL09930.1 - 2.7 8.0 6.7 3 7.9 0.0 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF3040) A_deaminase_N PF08451.6 ESL09931.1 - 0.033 14.2 0.4 0.055 13.4 0.3 1.3 1 0 0 1 1 1 0 Adenosine/AMP deaminase N-terminal AAA_17 PF13207.1 ESL09932.1 - 5.7e-06 27.1 0.0 1.2e-05 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL09932.1 - 6.5e-05 22.9 0.0 0.00015 21.7 0.0 1.6 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.24 ESL09932.1 - 6.8e-05 23.0 0.0 0.00043 20.4 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL09932.1 - 0.00037 20.2 0.0 0.0012 18.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESL09932.1 - 0.00075 19.8 0.0 0.0018 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL09932.1 - 0.0027 17.8 0.0 0.0069 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL09932.1 - 0.0029 17.4 0.0 0.0078 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Torsin PF06309.6 ESL09932.1 - 0.004 17.0 0.0 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 Torsin AAA_19 PF13245.1 ESL09932.1 - 0.0049 16.5 0.2 0.017 14.8 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 ESL09932.1 - 0.0055 15.8 0.1 0.031 13.3 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin RNA_helicase PF00910.17 ESL09932.1 - 0.0095 16.0 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 ESL09932.1 - 0.038 13.4 0.0 0.072 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 ESL09932.1 - 0.039 13.5 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Sigma54_activ_2 PF14532.1 ESL09932.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain PPV_E1_C PF00519.12 ESL09932.1 - 0.062 11.9 0.0 0.096 11.2 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase Sigma54_activat PF00158.21 ESL09932.1 - 0.083 12.3 0.0 0.4 10.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain KTI12 PF08433.5 ESL09932.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NB-ARC PF00931.17 ESL09932.1 - 0.12 11.2 0.3 0.25 10.1 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain DNA_pol_A PF00476.15 ESL09933.1 - 1e-30 106.6 0.0 2.9e-30 105.1 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 ESL09933.1 - 0.00044 19.7 0.0 0.0018 17.8 0.0 1.9 2 0 0 2 2 2 1 3'-5' exonuclease Hamartin PF04388.7 ESL09933.1 - 0.0029 16.3 0.2 0.011 14.4 0.0 1.9 2 0 0 2 2 2 1 Hamartin protein Bromo_TP PF07524.8 ESL09934.1 - 0.1 12.3 0.0 22 4.8 0.0 2.5 2 0 0 2 2 2 0 Bromodomain associated Mit_KHE1 PF10173.4 ESL09934.1 - 0.12 12.1 1.5 0.3 10.9 0.2 1.8 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF913 PF06025.7 ESL09934.1 - 0.27 9.9 1.9 0.45 9.2 0.0 1.9 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) DUF2346 PF09803.4 ESL09934.1 - 0.52 10.2 2.4 12 5.8 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2346) CPSase_L_D2 PF02786.12 ESL09935.1 - 1.3e-63 214.0 0.0 2.4e-63 213.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESL09935.1 - 3.8e-39 133.1 0.1 1.2e-38 131.6 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESL09935.1 - 2.2e-35 120.8 0.0 5.8e-35 119.5 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 ESL09935.1 - 2.7e-14 53.3 0.1 5.9e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESL09935.1 - 9.5e-12 44.7 0.0 4e-11 42.6 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.17 ESL09935.1 - 1.4e-11 43.8 0.0 2.7e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 ESL09935.1 - 1.6e-09 36.9 0.0 6e-08 31.7 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 ESL09935.1 - 2.7e-09 36.6 0.1 4.9e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 ESL09935.1 - 9.1e-06 25.2 0.0 6.9e-05 22.4 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESL09935.1 - 2e-05 24.1 0.0 4.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp_5 PF13549.1 ESL09935.1 - 0.0014 17.8 0.0 0.0036 16.5 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.14 ESL09935.1 - 0.039 13.4 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.9 ESL09935.1 - 0.081 12.7 0.0 0.27 11.1 0.0 1.9 1 1 0 1 1 1 0 ATP-grasp domain HlyD PF00529.15 ESL09935.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 HlyD family secretion protein HlyD_2 PF12700.2 ESL09935.1 - 0.13 11.4 0.0 1.4 7.9 0.0 2.1 1 1 1 2 2 2 0 HlyD family secretion protein Toxin_59 PF15537.1 ESL09935.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative toxin 59 CTDII PF01556.13 ESL09937.1 - 1.9e-28 98.1 2.5 1.3e-21 76.2 0.1 3.3 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ PF00226.26 ESL09937.1 - 3.8e-24 84.1 0.5 7.1e-24 83.3 0.4 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESL09937.1 - 6.8e-09 35.6 23.3 1.4e-08 34.6 16.1 1.6 1 0 0 1 1 1 1 DnaJ central domain UPF0126 PF03458.8 ESL09937.1 - 0.29 10.7 1.7 0.49 10.0 0.0 2.1 2 0 0 2 2 2 0 UPF0126 domain MCM PF00493.18 ESL09938.1 - 2.1e-55 187.8 0.5 2.9e-55 187.4 0.4 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 ESL09938.1 - 0.028 13.5 0.0 0.062 12.4 0.0 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF3138 PF11336.3 ESL09938.1 - 0.084 11.0 0.4 0.13 10.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Cmc1 PF08583.5 ESL09939.1 - 1.1e-06 28.3 1.4 1.1e-06 28.3 0.9 1.6 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.8 ESL09939.1 - 0.00027 20.2 1.8 0.00057 19.2 1.2 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cnd1_N PF12922.2 ESL09939.1 - 0.11 12.0 0.3 0.34 10.5 0.0 1.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Metallophos PF00149.23 ESL09940.1 - 1.2e-42 145.6 0.6 1.4e-42 145.4 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase His_Phos_1 PF00300.17 ESL09941.1 - 8.5e-11 42.1 0.0 1.3e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pro_isomerase PF00160.16 ESL09942.1 - 4.6e-24 85.3 0.0 5.7e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_C14 PF00656.17 ESL09944.1 - 3.8e-59 200.3 0.0 4.9e-59 200.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.1 ESL09944.1 - 0.087 12.6 0.1 11 5.8 0.0 2.3 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain Ribosomal_L13e PF01294.13 ESL09946.1 - 3.6e-52 176.4 7.2 3.6e-52 176.4 5.0 1.5 1 1 1 2 2 2 1 Ribosomal protein L13e tRNA-synt_2 PF00152.15 ESL09949.1 - 7.8e-64 215.5 0.0 1.2e-63 214.9 0.0 1.3 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESL09949.1 - 4.6e-07 29.6 0.0 7.8e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESL09949.1 - 9.4e-05 21.7 0.1 0.095 11.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Adeno_PV PF03910.8 ESL09949.1 - 0.18 10.8 0.6 0.25 10.3 0.4 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV PseudoU_synth_1 PF01416.15 ESL09950.1 - 5.7e-11 42.7 0.0 3.8e-08 33.7 0.0 3.3 3 1 0 3 3 3 2 tRNA pseudouridine synthase Pkinase PF00069.20 ESL09951.1 - 3e-53 180.6 0.0 3.5e-53 180.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09951.1 - 9.3e-18 64.2 0.0 1.2e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESL09951.1 - 0.00012 21.2 0.0 0.00022 20.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL09951.1 - 0.012 15.3 1.0 0.2 11.3 0.1 2.4 2 1 0 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL09951.1 - 0.015 14.3 0.0 0.025 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RNase_H2-Ydr279 PF09468.5 ESL09953.1 - 5.7e-20 71.7 0.0 1.1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) Serglycin PF04360.7 ESL09954.1 - 0.43 10.3 4.7 1.7 8.3 3.3 2.0 1 0 0 1 1 1 0 Serglycin Peptidase_M64 PF09471.5 ESL09957.1 - 1.1e-05 25.2 0.0 1.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 IgA Peptidase M64 DUF3357 PF11837.3 ESL09957.1 - 0.17 11.7 0.1 0.59 9.9 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Adeno_E3_CR2 PF02439.10 ESL09957.1 - 0.35 10.4 7.3 0.74 9.4 0.5 2.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Tetraspannin PF00335.15 ESL09957.1 - 1 8.5 20.8 0.037 13.3 9.0 2.1 2 0 0 2 2 2 0 Tetraspanin family FHA PF00498.21 ESL09958.1 - 1.1e-11 44.7 0.0 2.1e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain Sep15_SelM PF08806.6 ESL09959.1 - 0.082 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Sep15/SelM redox domain GAF_3 PF13492.1 ESL09960.1 - 0.045 13.8 0.0 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 GAF domain GAT PF03127.9 ESL09961.1 - 0.0062 16.4 0.8 0.015 15.2 0.6 1.6 1 0 0 1 1 1 1 GAT domain Atg14 PF10186.4 ESL09961.1 - 0.015 14.2 1.4 0.019 13.9 1.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Not3 PF04065.10 ESL09961.1 - 0.023 13.9 0.9 0.036 13.3 0.6 1.2 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component CENP-F_leu_zip PF10473.4 ESL09962.1 - 0.033 14.0 2.7 0.53 10.1 1.6 2.7 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Citrate_synt PF00285.16 ESL09964.1 - 2.3e-91 306.2 0.0 2.5e-91 306.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase KRBA1 PF15287.1 ESL09965.1 - 0.15 11.4 0.1 0.35 10.2 0.1 1.6 1 0 0 1 1 1 0 KRBA1 family repeat U3_assoc_6 PF08640.6 ESL09966.1 - 9.8e-17 60.4 0.3 2.1e-16 59.4 0.2 1.6 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 DUF365 PF04033.7 ESL09966.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF365) NYD-SP28 PF14772.1 ESL09967.1 - 1e-23 83.4 14.0 1e-23 83.4 9.7 6.3 4 2 3 7 7 7 1 Sperm tail NYD-SP28_assoc PF14775.1 ESL09967.1 - 1.2e-22 79.3 1.7 1.2e-22 79.3 1.2 4.0 4 0 0 4 4 4 1 Sperm tail C-terminal domain FTCD_C PF04961.7 ESL09967.1 - 2.5 7.4 14.3 0.5 9.7 0.3 4.3 2 1 1 4 4 4 0 Formiminotransferase-cyclodeaminase Pkinase PF00069.20 ESL09969.1 - 3.4e-33 114.9 0.0 2.1e-18 66.4 0.0 4.5 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09969.1 - 4.9e-06 25.8 1.3 0.018 14.1 0.1 4.2 4 0 0 4 4 4 2 Protein tyrosine kinase RIO1 PF01163.17 ESL09969.1 - 0.00076 18.8 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 RIO1 family DUF3709 PF12493.3 ESL09969.1 - 0.0077 15.8 0.4 0.023 14.4 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3709) AAA PF00004.24 ESL09970.1 - 3.9e-08 33.5 0.3 6.9e-08 32.7 0.2 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESL09970.1 - 0.00029 20.5 0.2 0.0011 18.6 0.0 2.0 2 0 0 2 2 1 1 Part of AAA domain AAA_22 PF13401.1 ESL09970.1 - 0.00044 20.3 0.1 0.002 18.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESL09970.1 - 0.00074 18.6 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 ESL09970.1 - 0.0013 17.8 0.1 0.0025 17.0 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESL09970.1 - 0.0015 18.2 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL09970.1 - 0.0015 18.5 0.3 0.015 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 ESL09970.1 - 0.0019 17.6 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 ESL09970.1 - 0.0053 16.3 0.1 0.0092 15.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL09970.1 - 0.0065 17.2 0.5 0.017 15.9 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESL09970.1 - 0.0095 15.3 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL09970.1 - 0.0096 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESL09970.1 - 0.019 14.6 0.1 0.036 13.7 0.1 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 ESL09970.1 - 0.021 14.9 0.0 0.054 13.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 ESL09970.1 - 0.026 13.6 0.6 0.28 10.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Parvo_NS1 PF01057.12 ESL09970.1 - 0.027 13.3 0.0 0.043 12.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TIP49 PF06068.8 ESL09970.1 - 0.035 12.8 0.0 0.05 12.3 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_28 PF13521.1 ESL09970.1 - 0.042 13.7 0.3 0.087 12.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ESL09970.1 - 0.063 12.5 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.1 ESL09970.1 - 0.082 13.2 0.2 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESL09970.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 ESL09970.1 - 0.12 12.0 0.0 0.73 9.4 0.0 1.9 2 0 0 2 2 2 0 Archaeal ATPase NB-ARC PF00931.17 ESL09970.1 - 0.15 10.8 0.2 0.48 9.2 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain DUF605 PF04652.11 ESL09970.1 - 9.1 5.5 13.6 12 5.1 9.5 1.1 1 0 0 1 1 1 0 Vta1 like Pkinase PF00069.20 ESL09971.1 - 1.1e-47 162.3 0.0 4.4e-47 160.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09971.1 - 1.6e-20 73.3 0.0 1.3e-16 60.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kelch_1 PF01344.20 ESL09971.1 - 0.00097 18.6 2.4 0.12 11.9 0.1 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ESL09971.1 - 0.0041 16.8 1.9 0.044 13.5 0.0 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Pox_ser-thr_kin PF05445.6 ESL09971.1 - 0.022 13.5 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Gpi1 PF05024.10 ESL09973.1 - 4.1e-36 124.4 7.4 4.1e-36 124.4 5.2 1.6 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) BRCT PF00533.21 ESL09975.1 - 7.2e-09 35.6 0.0 4.9e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 ESL09975.1 - 0.00041 20.1 1.2 0.37 10.6 0.5 3.4 3 1 0 3 3 3 2 twin BRCT domain Tctex-1 PF03645.8 ESL09976.1 - 9.8e-23 79.9 0.1 1.1e-22 79.7 0.1 1.0 1 0 0 1 1 1 1 Tctex-1 family WD40 PF00400.27 ESL09977.1 - 8.4e-05 22.3 0.2 0.008 16.0 0.2 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat MKT1_C PF12246.3 ESL09980.1 - 1.1e-09 37.7 0.0 1.3e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication LRR_6 PF13516.1 ESL09981.1 - 3.3e-07 29.6 2.9 0.012 15.6 0.2 3.3 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 ESL09981.1 - 6.2e-05 22.5 4.7 0.0033 17.0 3.5 2.8 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL09981.1 - 8.9e-05 22.0 2.2 0.77 10.0 0.1 3.5 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_8 PF13855.1 ESL09981.1 - 0.00062 19.4 3.4 0.005 16.5 2.3 2.3 1 1 1 2 2 2 1 Leucine rich repeat LRR_7 PF13504.1 ESL09981.1 - 0.012 15.6 0.9 4.5 7.9 0.0 3.2 3 0 0 3 3 3 0 Leucine rich repeat Alpha_kinase PF02816.13 ESL09982.1 - 1.7e-58 197.3 0.0 2.1e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Alpha-kinase family Baculo_PEP_C PF04513.7 ESL09983.1 - 0.08 12.7 0.2 8.4 6.2 0.1 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RNase_T PF00929.19 ESL09984.1 - 4.6e-22 79.0 0.0 6.3e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DUF3017 PF11222.3 ESL09984.1 - 0.091 12.5 3.6 0.81 9.5 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3017) Pkinase PF00069.20 ESL09986.1 - 9.8e-37 126.4 0.0 1.3e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL09986.1 - 3.2e-15 55.8 0.0 3.8e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL09986.1 - 0.0032 16.4 0.0 0.024 13.5 0.0 2.1 1 1 0 1 1 1 1 Kinase-like GRAM PF02893.15 ESL09987.1 - 7.6e-17 60.5 0.6 3e-07 29.8 0.0 2.6 2 0 0 2 2 2 2 GRAM domain Fibritin_C PF07921.7 ESL09988.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 Fibritin C-terminal region YfdX PF10938.3 ESL09988.1 - 0.073 12.7 3.3 3.8 7.1 0.1 3.3 4 0 0 4 4 4 0 YfdX protein TPR_14 PF13428.1 ESL09988.1 - 0.14 12.8 5.5 35 5.4 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat RNA_pol_Rpb5_C PF01191.14 ESL09989.1 - 8.1e-29 99.0 0.1 1.4e-28 98.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 ESL09989.1 - 3.8e-23 81.7 0.9 1e-22 80.3 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain DUF3479 PF11965.3 ESL09989.1 - 0.093 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) FUSC PF04632.7 ESL09990.1 - 0.067 11.6 2.7 0.081 11.3 1.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family HALZ PF02183.13 ESL09990.1 - 0.11 12.1 1.4 1.4 8.6 0.2 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper Lipase_3 PF01764.20 ESL09991.1 - 0.0025 17.4 0.0 0.0066 16.0 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Matrilin_ccoil PF10393.4 ESL09991.1 - 0.17 11.3 0.1 0.33 10.3 0.0 1.5 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin PmbA_TldD PF01523.11 ESL09992.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Rhodanese PF00581.15 ESL09996.1 - 8.6e-14 51.8 0.0 2e-13 50.6 0.0 1.6 2 0 0 2 2 2 1 Rhodanese-like domain ALF PF03752.8 ESL09996.1 - 0.051 13.4 0.1 0.092 12.6 0.1 1.4 1 0 0 1 1 1 0 Short repeats of unknown function Ala_racemase_N PF01168.15 ESL09998.1 - 0.0059 16.1 0.5 0.011 15.3 0.4 1.5 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain MRP-S28 PF10213.4 ESL09998.1 - 0.0096 15.9 4.7 0.016 15.3 3.3 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein DUF3259 PF11652.3 ESL09998.1 - 0.039 14.1 1.5 0.11 12.6 0.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3259) NusB PF01029.13 ESL09998.1 - 0.06 13.3 8.1 0.018 14.9 3.7 1.6 2 0 0 2 2 2 0 NusB family Speriolin_N PF15058.1 ESL09998.1 - 0.5 10.2 2.0 0.69 9.7 1.4 1.3 1 0 0 1 1 1 0 Speriolin N terminus FAM176 PF14851.1 ESL09998.1 - 1.9 8.1 9.3 3.3 7.3 6.3 1.5 1 1 0 1 1 1 0 FAM176 family BTAD PF03704.12 ESL09999.1 - 0.12 12.6 6.1 0.21 11.8 0.1 2.7 2 1 0 2 2 2 0 Bacterial transcriptional activator domain DUF2353 PF09789.4 ESL09999.1 - 0.15 11.2 1.4 0.23 10.6 1.0 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) RRP7 PF12923.2 ESL10000.1 - 0.0052 16.8 5.3 0.0052 16.8 3.7 3.6 2 2 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) 2OG-FeII_Oxy PF03171.15 ESL10001.1 - 1.3e-08 35.0 0.0 2.4e-08 34.1 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DOT1 PF08123.8 ESL10002.1 - 3e-11 43.0 0.0 4e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 ESL10002.1 - 7.6e-08 32.9 0.0 1.1e-07 32.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL10002.1 - 1.1e-06 28.7 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10002.1 - 1.1e-06 28.3 0.0 1.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10002.1 - 3.5e-05 24.0 0.0 6.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL10002.1 - 0.00034 21.0 0.0 0.00062 20.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESL10002.1 - 0.0033 17.1 0.0 0.005 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.8 ESL10002.1 - 0.0091 16.1 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_4 PF02390.12 ESL10002.1 - 0.035 13.1 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.9 ESL10002.1 - 0.039 13.3 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 ESL10002.1 - 0.041 12.9 0.0 0.055 12.5 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.7 ESL10002.1 - 0.05 12.9 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.7 ESL10002.1 - 0.057 13.9 0.0 0.083 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 ESL10002.1 - 0.1 12.1 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PPR_3 PF13812.1 ESL10003.1 - 0.0016 18.6 0.4 0.26 11.6 0.1 3.6 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESL10003.1 - 0.044 13.7 0.0 1.6 8.7 0.0 2.4 1 1 0 1 1 1 0 PPR repeat family Pkinase PF00069.20 ESL10004.1 - 5.7e-33 114.1 0.0 1.8e-32 112.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10004.1 - 2.6e-11 43.1 0.0 1.6e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Apc3 PF12895.2 ESL10006.1 - 0.0042 17.1 0.1 0.34 11.0 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Lac_bphage_repr PF06543.7 ESL10006.1 - 0.16 11.5 0.5 0.32 10.5 0.3 1.4 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor tRNA_U5-meth_tr PF05958.6 ESL10007.1 - 2.8e-16 59.1 0.0 2.5e-15 56.0 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 ESL10007.1 - 3.5e-14 52.6 0.0 5.8e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL10007.1 - 2.1e-09 37.4 0.0 4.1e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10007.1 - 3.7e-09 37.1 0.0 7.3e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL10007.1 - 2.2e-08 33.6 0.0 4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESL10007.1 - 2.7e-07 30.8 0.0 5.9e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 ESL10007.1 - 2.9e-05 23.5 0.0 5.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.5 ESL10007.1 - 0.00015 21.3 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.7 ESL10007.1 - 0.00023 21.6 0.0 0.00051 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESL10007.1 - 0.00037 20.1 0.0 0.0006 19.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.8 ESL10007.1 - 0.00048 19.3 0.2 0.0008 18.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 ESL10007.1 - 0.00059 18.9 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 ESL10007.1 - 0.0012 18.0 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family UPF0020 PF01170.13 ESL10007.1 - 0.002 17.7 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TPMT PF05724.6 ESL10007.1 - 0.0025 17.2 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_32 PF13679.1 ESL10007.1 - 0.0036 17.0 0.1 0.013 15.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL10007.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESL10007.1 - 0.028 14.9 0.0 0.06 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 ESL10007.1 - 0.069 12.1 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DREV PF05219.7 ESL10007.1 - 0.078 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase NodS PF05401.6 ESL10007.1 - 0.091 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) Aa_trans PF01490.13 ESL10008.1 - 6.6e-40 136.8 22.9 7.9e-40 136.5 15.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Adaptin_N PF01602.15 ESL10009.1 - 4.2e-13 48.4 0.1 6.1e-13 47.9 0.1 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Pox_Ag35 PF03286.9 ESL10011.1 - 0.023 14.2 0.3 0.043 13.3 0.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein hNIFK_binding PF12196.3 ESL10011.1 - 0.76 9.2 6.8 1.9 7.9 4.7 1.6 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Methyltransf_23 PF13489.1 ESL10012.1 - 1e-22 80.6 0.0 1.4e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL10012.1 - 6.4e-08 32.9 0.0 1.6e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL10012.1 - 2.3e-05 24.7 0.0 0.00016 22.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10012.1 - 4e-05 23.2 0.0 0.00011 21.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10012.1 - 9.6e-05 22.9 0.0 0.00028 21.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10012.1 - 0.0028 17.9 0.0 0.03 14.6 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL10012.1 - 0.047 13.7 0.0 0.1 12.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain His_Phos_2 PF00328.17 ESL10013.1 - 3.8e-22 79.0 0.9 1.3e-14 54.3 0.2 2.7 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) TPPK_C PF12555.3 ESL10013.1 - 0.016 14.8 0.1 0.016 14.8 0.1 1.9 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Rab3-GTPase_cat PF13890.1 ESL10013.1 - 0.15 11.4 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit Apc3 PF12895.2 ESL10014.1 - 5.4e-05 23.2 1.0 0.42 10.7 0.0 4.0 3 2 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESL10014.1 - 5.5e-05 22.7 3.6 0.52 10.3 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10014.1 - 6.8e-05 23.1 9.0 0.4 11.4 0.0 6.6 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10014.1 - 0.00016 21.2 10.3 0.045 13.3 0.0 5.6 5 2 2 7 7 7 2 TPR repeat TPR_12 PF13424.1 ESL10014.1 - 0.00064 19.5 11.1 6.5 6.7 0.0 6.5 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL10014.1 - 0.003 17.1 2.8 0.3 10.7 0.0 4.6 6 0 0 6 6 6 1 Tetratricopeptide repeat Peptidase_C58 PF03543.9 ESL10014.1 - 0.0057 16.1 1.1 0.014 14.9 0.8 1.6 1 0 0 1 1 1 1 Yersinia/Haemophilus virulence surface antigen TPR_8 PF13181.1 ESL10014.1 - 0.047 13.4 0.9 22 5.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3512 PF12024.3 ESL10014.1 - 0.053 12.8 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3512) CUE PF02845.11 ESL10014.1 - 0.079 12.4 0.4 0.33 10.4 0.1 2.3 2 0 0 2 2 2 0 CUE domain TPR_16 PF13432.1 ESL10014.1 - 0.36 11.5 15.3 15 6.3 0.8 5.6 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESL10014.1 - 1.8 9.2 14.1 37 5.1 0.4 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10014.1 - 2.2 8.8 8.0 31 5.3 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESL10014.1 - 2.9 8.3 10.3 7.9 6.9 0.1 5.8 8 0 0 8 8 7 0 Tetratricopeptide repeat Steroid_dh PF02544.11 ESL10016.1 - 0.038 13.7 5.1 0.15 11.8 0.5 3.0 3 0 0 3 3 3 0 3-oxo-5-alpha-steroid 4-dehydrogenase E1-E2_ATPase PF00122.15 ESL10017.1 - 2.1e-62 210.1 3.6 2.1e-62 210.1 2.5 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESL10017.1 - 4.1e-28 98.1 7.1 4.1e-28 98.1 4.9 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESL10017.1 - 3.8e-21 76.5 0.0 2.6e-20 73.7 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL10017.1 - 5.3e-16 58.3 0.0 1.6e-15 56.8 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESL10017.1 - 3.9e-09 36.9 0.2 4.3e-08 33.5 0.1 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESL10017.1 - 5.5e-08 32.1 0.0 1.6e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESL10017.1 - 2.1e-05 24.2 0.4 3.5e-05 23.4 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LSM PF01423.17 ESL10019.1 - 1.1e-14 53.6 0.2 1.3e-14 53.4 0.1 1.0 1 0 0 1 1 1 1 LSM domain RuvA_C PF07499.8 ESL10021.1 - 0.017 15.2 0.5 0.38 10.9 0.0 2.4 2 0 0 2 2 2 0 RuvA, C-terminal domain Epimerase PF01370.16 ESL10022.1 - 1.1e-18 67.5 0.0 4.7e-18 65.4 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL10022.1 - 1e-09 37.6 0.0 1.2e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESL10022.1 - 3.1e-06 26.3 0.0 2.4e-05 23.3 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESL10022.1 - 5e-05 22.1 0.0 6.7e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 ESL10022.1 - 9.3e-05 21.4 0.0 0.0002 20.3 0.0 1.4 1 1 1 2 2 2 1 Male sterility protein adh_short PF00106.20 ESL10022.1 - 0.038 13.9 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Dynein_heavy PF03028.10 ESL10023.1 - 1.1e-68 231.9 0.0 1.3e-68 231.7 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF1771 PF08590.5 ESL10024.1 - 4.1e-16 58.7 0.7 8.4e-16 57.7 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.11 ESL10024.1 - 6.1e-13 47.9 0.0 0.00095 18.6 0.0 3.8 3 0 0 3 3 3 3 CUE domain Smr PF01713.16 ESL10024.1 - 1.6e-12 47.4 0.0 3.7e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Smr domain UBA PF00627.26 ESL10024.1 - 0.00053 19.7 0.0 0.14 12.0 0.0 3.0 2 0 0 2 2 2 2 UBA/TS-N domain Sedlin_N PF04628.8 ESL10025.1 - 9e-07 28.8 0.0 1.4e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region FOP_dimer PF09398.5 ESL10026.1 - 0.007 16.3 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 FOP N terminal dimerisation domain Spc7 PF08317.6 ESL10026.1 - 1.1 7.8 10.7 0.11 11.1 4.1 1.8 2 1 0 2 2 2 0 Spc7 kinetochore protein Oxysterol_BP PF01237.13 ESL10027.1 - 1.8e-45 155.0 0.0 6.3e-45 153.1 0.0 1.7 1 1 0 1 1 1 1 Oxysterol-binding protein AAA PF00004.24 ESL10028.1 - 2.9e-42 143.9 0.0 5.7e-42 143.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL10028.1 - 7e-07 29.4 0.0 0.00017 21.7 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL10028.1 - 1.6e-06 27.8 0.1 5.6e-05 22.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESL10028.1 - 8.2e-06 25.8 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESL10028.1 - 1.6e-05 25.0 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESL10028.1 - 4.7e-05 24.1 0.1 0.00013 22.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL10028.1 - 0.00024 20.2 0.0 0.00058 18.9 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ESL10028.1 - 0.00037 19.4 0.0 0.00071 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESL10028.1 - 0.00062 19.4 0.1 0.0015 18.2 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 ESL10028.1 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESL10028.1 - 0.0013 18.6 0.0 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL10028.1 - 0.0016 17.5 0.0 0.0028 16.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Arch_ATPase PF01637.13 ESL10028.1 - 0.0025 17.5 0.0 0.25 11.0 0.0 2.4 1 1 1 2 2 2 1 Archaeal ATPase AAA_33 PF13671.1 ESL10028.1 - 0.0027 17.5 0.0 0.0053 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESL10028.1 - 0.0028 17.0 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL10028.1 - 0.0045 17.1 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 ESL10028.1 - 0.0074 16.5 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESL10028.1 - 0.0079 15.3 0.0 0.019 14.1 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 ESL10028.1 - 0.0088 15.6 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL10028.1 - 0.0097 14.6 0.0 0.016 13.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_3 PF07726.6 ESL10028.1 - 0.012 15.2 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESL10028.1 - 0.018 14.4 1.9 0.15 11.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 ESL10028.1 - 0.018 14.7 0.1 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 NTPase Sigma54_activat PF00158.21 ESL10028.1 - 0.04 13.4 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Histone PF00125.19 ESL10028.1 - 0.053 13.6 0.1 0.19 11.8 0.0 2.0 2 0 0 2 2 1 0 Core histone H2A/H2B/H3/H4 PhoH PF02562.11 ESL10028.1 - 0.067 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.12 ESL10028.1 - 0.067 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 KaiC PF06745.8 ESL10028.1 - 0.085 11.9 0.0 0.29 10.2 0.0 1.9 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.17 ESL10028.1 - 0.09 11.6 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.1 ESL10028.1 - 0.12 11.9 0.0 0.27 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 ESL10028.1 - 0.13 12.2 0.0 0.36 10.8 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Phage_Gp23 PF10669.4 ESL10029.1 - 0.11 12.5 1.9 0.2 11.7 1.3 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) zf-HIT PF04438.11 ESL10030.1 - 1.1e-05 24.9 16.3 1.9e-05 24.1 11.3 1.4 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.19 ESL10030.1 - 0.016 15.0 9.9 0.036 13.9 6.9 1.6 1 0 0 1 1 1 0 B-box zinc finger DUF4200 PF13863.1 ESL10030.1 - 0.037 13.9 1.8 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) zf-MYND PF01753.13 ESL10030.1 - 0.043 13.7 12.8 0.098 12.5 8.9 1.6 1 0 0 1 1 1 0 MYND finger FYVE PF01363.16 ESL10030.1 - 3.5 7.5 11.4 6.7 6.6 7.9 1.6 1 1 0 1 1 1 0 FYVE zinc finger Tnp_zf-ribbon_2 PF13842.1 ESL10030.1 - 4.8 7.6 15.9 13 6.2 9.3 2.7 2 1 1 3 3 3 0 DDE_Tnp_1-like zinc-ribbon zf-C3HC4_3 PF13920.1 ESL10030.1 - 7.1 6.3 13.5 2.2 8.0 7.4 1.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Shisa PF13908.1 ESL10030.1 - 7.6 6.6 13.0 3.8 7.6 7.5 1.6 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Lipase_3 PF01764.20 ESL10031.1 - 3.6e-06 26.6 0.0 5.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) BRO1 PF03097.13 ESL10032.1 - 1.9e-17 63.1 0.2 2e-17 63.0 0.1 1.1 1 0 0 1 1 1 1 BRO1-like domain TFIID_90kDa PF04494.10 ESL10032.1 - 0.054 13.5 0.3 0.12 12.4 0.2 1.5 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit ABC_tran PF00005.22 ESL10033.1 - 6.2e-28 97.7 0.0 9.9e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESL10033.1 - 2.4e-09 37.5 0.3 8.5e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 ESL10033.1 - 0.0059 15.8 0.1 0.22 10.7 0.0 2.2 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 ESL10033.1 - 0.0075 16.1 0.8 0.11 12.4 0.1 2.8 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 ESL10033.1 - 0.072 12.6 0.2 0.16 11.5 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 ESL10033.1 - 0.094 12.3 1.5 0.33 10.5 0.2 2.1 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.1 ESL10033.1 - 0.11 11.9 0.5 0.65 9.3 0.1 2.3 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 ESL10033.1 - 0.13 12.0 0.5 0.93 9.2 0.1 2.3 2 0 0 2 2 2 0 Part of AAA domain RrnaAD PF00398.15 ESL10034.1 - 3.5e-60 203.2 0.0 4.4e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 ESL10034.1 - 5.9e-11 42.4 0.0 8.8e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10034.1 - 1.5e-06 28.7 0.0 2.4e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10034.1 - 4.2e-06 26.4 0.0 6.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL10034.1 - 2.9e-05 23.8 0.0 5.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL10034.1 - 3.2e-05 23.3 0.0 6.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 ESL10034.1 - 0.00011 22.5 0.0 0.00024 21.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESL10034.1 - 0.00087 18.8 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 ESL10034.1 - 0.0015 18.9 0.0 0.0032 17.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10034.1 - 0.0018 18.5 0.0 0.0037 17.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Pox_D5 PF03288.11 ESL10034.1 - 0.005 17.0 0.3 0.011 15.9 0.2 1.6 1 0 0 1 1 1 1 Poxvirus D5 protein-like Methyltransf_4 PF02390.12 ESL10034.1 - 0.0098 14.9 0.0 0.021 13.8 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase NodS PF05401.6 ESL10034.1 - 0.018 14.4 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.7 ESL10034.1 - 0.045 12.6 0.0 0.073 11.9 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase LELP1 PF15042.1 ESL10034.1 - 0.098 12.8 0.5 4.9 7.3 0.2 2.3 2 0 0 2 2 2 0 Late cornified envelope-like proline-rich protein 1 Ubie_methyltran PF01209.13 ESL10034.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Abhydrolase_5 PF12695.2 ESL10035.1 - 1.1e-21 77.1 0.0 1.6e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESL10035.1 - 7.9e-20 71.7 0.1 2.2e-19 70.2 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL10035.1 - 3.8e-09 36.4 0.0 1.6e-07 31.1 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 ESL10035.1 - 8.4e-07 28.7 0.1 1.5e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ESL10035.1 - 5.2e-06 26.0 0.0 0.00078 18.9 0.0 2.4 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase AXE1 PF05448.7 ESL10035.1 - 5.9e-06 25.0 0.0 0.0047 15.4 0.0 3.0 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 ESL10035.1 - 6e-06 25.6 0.0 0.00011 21.4 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.13 ESL10035.1 - 1.4e-05 24.5 0.0 0.15 11.2 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S15 PF02129.13 ESL10035.1 - 0.00028 20.3 0.0 0.19 11.1 0.0 2.1 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.6 ESL10035.1 - 0.0015 18.2 0.0 0.02 14.6 0.0 2.1 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.3 ESL10035.1 - 0.0048 16.7 0.0 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 Putative lysophospholipase FSH1 PF03959.8 ESL10035.1 - 0.0062 16.0 0.0 0.017 14.5 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DUF1749 PF08538.5 ESL10035.1 - 0.016 14.1 0.0 0.36 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Lipase_3 PF01764.20 ESL10035.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) CorA PF01544.13 ESL10036.1 - 1.5e-15 57.0 1.0 2.1e-15 56.5 0.7 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Claudin_2 PF13903.1 ESL10036.1 - 0.077 12.6 1.0 0.67 9.6 0.1 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Ank_2 PF12796.2 ESL10037.1 - 3.2e-32 110.7 0.2 1.4e-13 50.9 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL10037.1 - 2.8e-28 97.7 3.0 9.7e-08 32.3 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL10037.1 - 7.3e-24 83.2 3.0 6.8e-09 35.6 0.2 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 ESL10037.1 - 1e-23 81.8 0.8 9.8e-06 25.1 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.1 ESL10037.1 - 4.1e-16 57.4 0.2 0.0074 16.4 0.0 5.6 6 0 0 6 6 6 4 Ankyrin repeat adh_short_C2 PF13561.1 ESL10039.1 - 4.5e-18 65.9 0.0 1.2e-14 54.7 0.0 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 ESL10039.1 - 8e-15 55.1 1.6 2.1e-14 53.7 0.6 2.0 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ESL10039.1 - 0.0038 16.9 2.0 0.0089 15.7 0.3 2.2 2 1 1 3 3 3 1 KR domain PLAC8 PF04749.12 ESL10039.1 - 0.017 15.6 0.0 0.031 14.8 0.0 1.4 1 0 0 1 1 1 0 PLAC8 family NAD_binding_10 PF13460.1 ESL10039.1 - 0.022 14.7 1.3 0.12 12.3 0.7 2.0 2 0 0 2 2 2 0 NADH(P)-binding Epimerase PF01370.16 ESL10039.1 - 0.096 12.1 0.0 0.44 9.9 0.0 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family WD40 PF00400.27 ESL10041.1 - 5.6e-06 26.0 10.8 0.38 10.7 0.2 4.8 4 1 0 4 4 4 3 WD domain, G-beta repeat Dynein_heavy PF03028.10 ESL10041.1 - 0.00077 17.6 0.0 0.0011 17.1 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor PQQ_3 PF13570.1 ESL10041.1 - 0.0057 16.9 1.3 9.5 6.6 0.0 4.3 5 0 0 5 5 5 2 PQQ-like domain PQQ PF01011.16 ESL10041.1 - 0.017 14.5 0.0 0.29 10.7 0.0 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat Methyltransf_14 PF08484.6 ESL10042.1 - 0.16 11.5 0.9 1.3 8.5 0.1 2.6 2 1 1 3 3 3 0 C-methyltransferase C-terminal domain F-box-like PF12937.2 ESL10043.1 - 0.0051 16.5 2.2 0.013 15.2 1.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESL10043.1 - 0.012 15.2 1.4 0.027 14.1 0.9 1.6 1 0 0 1 1 1 0 F-box domain Peptidase_S66 PF02016.10 ESL10045.1 - 0.27 10.1 1.5 0.82 8.5 1.0 1.8 1 0 0 1 1 1 0 LD-carboxypeptidase KMP11 PF03037.11 ESL10046.1 - 2e-56 188.5 17.0 2.2e-56 188.4 11.8 1.0 1 0 0 1 1 1 1 Kinetoplastid membrane protein 11 Apolipoprotein PF01442.13 ESL10046.1 - 0.0068 15.9 3.3 0.016 14.7 2.3 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain AAA_32 PF13654.1 ESL10046.1 - 0.012 14.3 3.6 0.013 14.2 2.5 1.0 1 0 0 1 1 1 0 AAA domain FCH PF00611.18 ESL10046.1 - 0.012 15.7 1.0 0.012 15.7 0.7 1.9 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Lyase_8_N PF08124.6 ESL10046.1 - 0.021 13.6 1.7 0.022 13.6 1.2 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF3584 PF12128.3 ESL10046.1 - 0.058 10.7 4.0 0.07 10.4 2.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TroA PF01297.12 ESL10046.1 - 0.075 12.2 1.8 2.2 7.4 0.1 2.0 1 1 1 2 2 2 0 Periplasmic solute binding protein family Brr6_like_C_C PF10104.4 ESL10046.1 - 0.086 12.3 0.5 0.093 12.2 0.3 1.1 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Metal_resist PF13801.1 ESL10046.1 - 0.099 12.6 1.3 0.32 10.9 0.2 1.9 1 1 1 2 2 2 0 Heavy-metal resistance THP2 PF09432.5 ESL10046.1 - 0.11 12.3 1.6 0.13 12.0 1.1 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 FliD_C PF07195.7 ESL10046.1 - 0.15 11.3 1.9 0.23 10.7 1.3 1.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus T5orf172 PF10544.4 ESL10046.1 - 0.17 12.2 2.2 0.2 12.0 1.5 1.2 1 0 0 1 1 1 0 T5orf172 domain Mating_N PF12731.2 ESL10046.1 - 0.17 11.7 1.2 0.25 11.2 0.8 1.3 1 0 0 1 1 1 0 Mating-type protein beta 1 GrpE PF01025.14 ESL10046.1 - 0.21 11.1 5.5 0.22 11.0 3.8 1.1 1 0 0 1 1 1 0 GrpE DIOX_N PF14226.1 ESL10046.1 - 0.32 11.5 4.6 0.38 11.2 3.2 1.1 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal DUF4404 PF14357.1 ESL10046.1 - 0.34 11.3 3.5 1.1 9.6 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) NYD-SP28 PF14772.1 ESL10046.1 - 0.44 10.6 6.7 4.1 7.5 0.2 2.4 2 1 0 2 2 2 0 Sperm tail ARL2_Bind_BART PF11527.3 ESL10046.1 - 0.52 10.1 9.1 0.85 9.4 6.3 1.3 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART YlqD PF11068.3 ESL10046.1 - 0.56 10.2 6.8 1.2 9.1 4.7 1.5 1 1 0 1 1 1 0 YlqD protein Vps54 PF07928.7 ESL10046.1 - 0.83 9.7 3.7 0.56 10.3 1.2 1.6 2 0 0 2 2 2 0 Vps54-like protein DUF2884 PF11101.3 ESL10046.1 - 1.1 8.5 8.3 2 7.7 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) Mitofilin PF09731.4 ESL10046.1 - 9.2 4.7 10.4 11 4.5 7.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein BAF1_ABF1 PF04684.8 ESL10047.1 - 0.11 11.2 4.9 0.18 10.6 3.4 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4557 PF15101.1 ESL10047.1 - 2.1 8.1 7.4 0.93 9.2 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Acyl-CoA_dh_C PF12806.2 ESL10048.1 - 2.6e-25 88.7 0.1 6.7e-25 87.4 0.0 1.7 2 0 0 2 2 2 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_1 PF00441.19 ESL10048.1 - 1.8e-16 60.5 0.7 1.9e-15 57.2 0.5 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESL10048.1 - 5.4e-15 55.9 0.0 1.1e-14 55.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESL10048.1 - 2.7e-12 46.0 0.0 6e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESL10048.1 - 0.00013 22.2 0.0 0.00034 20.8 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AcylCoA_DH_N PF12418.3 ESL10048.1 - 0.0059 16.2 0.2 0.015 14.9 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase N terminal XPG_I PF00867.13 ESL10049.1 - 1.2e-29 102.1 0.0 2.2e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 ESL10049.1 - 1.7e-26 92.3 0.0 3.6e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 ESL10049.1 - 1.6e-05 25.0 0.0 7e-05 23.0 0.0 2.0 2 1 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Sigma70_r1_1 PF03979.9 ESL10049.1 - 0.0014 18.5 0.5 0.0035 17.2 0.4 1.6 1 0 0 1 1 1 1 Sigma-70 factor, region 1.1 XPG_I_2 PF12813.2 ESL10049.1 - 0.041 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 XPG domain containing EI24 PF07264.6 ESL10051.1 - 3.3e-37 128.0 16.1 4.8e-37 127.5 10.6 1.7 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Helicase_C PF00271.26 ESL10052.1 - 2.5e-14 52.8 0.1 9.6e-14 51.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL10052.1 - 2.9e-14 52.9 0.0 4.1e-13 49.1 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 ESL10052.1 - 0.02 14.7 0.0 0.15 11.8 0.0 2.4 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit SURF2 PF05477.6 ESL10053.1 - 0.00098 18.3 10.3 0.0022 17.1 7.2 1.5 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) Adaptin_N PF01602.15 ESL10053.1 - 0.029 12.7 0.2 7.2 4.7 0.1 3.0 4 0 0 4 4 4 0 Adaptin N terminal region EF-hand_6 PF13405.1 ESL10054.1 - 0.00033 20.2 0.1 0.0044 16.7 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 ESL10054.1 - 0.013 14.7 0.1 0.089 12.1 0.0 2.4 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.27 ESL10054.1 - 0.017 14.4 0.0 0.062 12.6 0.0 2.1 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.1 ESL10054.1 - 0.035 14.2 0.2 0.093 12.8 0.0 1.9 2 1 0 2 2 2 0 EF-hand domain pair zf-RING_2 PF13639.1 ESL10055.1 - 6.5e-10 38.6 13.9 1.2e-09 37.8 9.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESL10055.1 - 9.8e-06 25.1 12.5 1.7e-05 24.4 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL10055.1 - 2e-05 24.5 13.4 3.8e-05 23.6 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESL10055.1 - 0.024 14.7 11.7 0.046 13.8 8.1 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_5 PF14634.1 ESL10055.1 - 0.18 11.5 14.5 0.34 10.6 10.1 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Mito_fiss_reg PF05308.6 ESL10055.1 - 0.18 11.1 9.9 1.4 8.1 2.0 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator LIM PF00412.17 ESL10055.1 - 6.5 6.9 14.2 68 3.6 5.8 2.3 1 1 1 2 2 2 0 LIM domain Ribosomal_L22 PF00237.14 ESL10056.1 - 6.2e-14 51.8 0.0 8.7e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e TPR_16 PF13432.1 ESL10058.1 - 0.013 16.1 2.1 0.024 15.3 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10058.1 - 0.11 12.1 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_14 PF13428.1 ESL10058.1 - 0.38 11.5 8.5 0.24 12.1 0.9 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESL10058.1 - 0.39 11.2 0.1 0.39 11.2 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Exo_endo_phos PF03372.18 ESL10059.1 - 5.8e-12 46.0 0.0 2.3e-10 40.8 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1206 PF06724.6 ESL10060.1 - 0.58 9.9 3.9 9.5 6.0 0.1 3.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1206) Peptidase_M16 PF00675.15 ESL10061.1 - 2.5e-11 43.5 0.0 4.2e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESL10061.1 - 4.1e-06 26.5 0.0 1e-05 25.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase M16 inactive domain WD40 PF00400.27 ESL10062.1 - 7.5e-81 263.3 18.5 4.6e-10 38.9 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat Nup160 PF11715.3 ESL10062.1 - 8.1e-07 27.5 11.4 0.53 8.3 0.0 6.4 1 1 4 6 6 6 5 Nucleoporin Nup120/160 CEP19 PF14933.1 ESL10062.1 - 0.00056 20.2 0.0 0.00081 19.7 0.0 1.2 1 0 0 1 1 1 1 CEP19-like protein UPF0506 PF11703.3 ESL10062.1 - 0.26 11.2 8.7 6.6 6.7 0.6 4.3 4 0 0 4 4 4 0 UPF0506 Methyltransf_26 PF13659.1 ESL10063.1 - 0.032 14.2 4.4 0.24 11.4 2.4 2.6 1 1 0 1 1 1 0 Methyltransferase domain EcoRI_methylase PF13651.1 ESL10063.1 - 0.14 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Adenine-specific methyltransferase EcoRI Adeno_VII PF03228.9 ESL10063.1 - 6.4 7.4 8.0 0.31 11.6 1.2 2.0 3 0 0 3 3 3 0 Adenoviral core protein VII Kinesin PF00225.18 ESL10065.1 - 1.6e-76 257.1 1.2 2.6e-76 256.5 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Mcp5_PH PF12814.2 ESL10065.1 - 2.3e-06 27.5 0.0 4.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.24 ESL10065.1 - 0.0081 16.3 0.0 0.028 14.6 0.0 2.0 1 0 0 1 1 1 1 PH domain DUF1168 PF06658.7 ESL10065.1 - 3.5 7.1 22.7 7.8 6.0 15.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Pkinase PF00069.20 ESL10066.1 - 3.3e-47 160.8 0.1 1.5e-40 138.9 0.0 3.6 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10066.1 - 1.1e-14 54.1 0.1 3.1e-08 33.0 0.0 3.6 4 0 0 4 4 4 2 Protein tyrosine kinase Kdo PF06293.9 ESL10066.1 - 0.00075 18.6 0.1 0.0016 17.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL10066.1 - 0.0062 16.3 0.3 0.014 15.1 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL10066.1 - 0.03 13.3 0.0 3.5 6.5 0.0 2.8 3 0 0 3 3 3 0 Kinase-like PIP49_C PF12260.3 ESL10066.1 - 0.14 11.5 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Mem_trans PF03547.13 ESL10067.1 - 8.4e-10 37.4 0.1 7.9e-09 34.2 0.1 1.9 1 1 0 1 1 1 1 Membrane transport protein PPR PF01535.15 ESL10068.1 - 8.9e-31 103.7 30.9 0.0064 16.3 0.0 15.8 18 0 0 18 18 18 9 PPR repeat PPR_2 PF13041.1 ESL10068.1 - 5.7e-28 96.6 18.0 4.6e-05 23.3 0.1 12.8 7 3 7 14 14 14 8 PPR repeat family PPR_3 PF13812.1 ESL10068.1 - 4.1e-26 89.0 14.1 0.08 13.2 0.1 15.5 15 1 1 16 16 16 6 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESL10068.1 - 1.9e-07 30.4 0.6 0.036 13.5 0.0 6.1 7 0 0 7 7 7 2 PPR repeat TPR_19 PF14559.1 ESL10068.1 - 7.5e-07 29.4 2.6 0.00049 20.3 1.6 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat Clathrin PF00637.15 ESL10068.1 - 0.0013 18.3 18.5 0.76 9.3 0.1 6.6 6 1 1 7 7 7 2 Region in Clathrin and VPS RhoGAP PF00620.22 ESL10068.1 - 0.003 17.1 2.3 11 5.6 0.0 4.1 3 1 0 3 3 3 2 RhoGAP domain Peptidase_M20 PF01546.23 ESL10070.1 - 6.4e-21 74.7 0.0 1.1e-20 73.9 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESL10070.1 - 7.1e-13 48.2 0.0 1.1e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain DNA_pol_E_B PF04042.11 ESL10071.1 - 3.1e-05 23.3 0.0 8.7e-05 21.8 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF4379 PF14311.1 ESL10072.1 - 3.2e-28 97.3 31.0 1.1e-10 41.1 0.1 4.8 4 1 0 4 4 4 4 Domain of unknown function (DUF4379) SprT-like PF10263.4 ESL10072.1 - 5 6.7 14.8 5.3 6.6 0.4 3.6 4 0 0 4 4 4 0 SprT-like family Ribul_P_3_epim PF00834.14 ESL10073.1 - 2.3e-09 36.6 0.1 2.6e-09 36.4 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Amidohydro_1 PF01979.15 ESL10074.1 - 8.3e-34 117.7 0.0 1e-33 117.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 ESL10074.1 - 2e-05 24.3 0.0 6.1e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 ESL10074.1 - 0.02 14.9 0.2 0.093 12.7 0.0 2.1 2 1 0 2 2 2 0 Amidohydrolase A_deaminase PF00962.17 ESL10074.1 - 0.071 12.0 0.0 0.13 11.1 0.0 1.4 1 1 0 1 1 1 0 Adenosine/AMP deaminase Amidohydro_3 PF07969.6 ESL10074.1 - 0.096 11.8 0.1 13 4.8 0.1 2.5 2 1 0 2 2 2 0 Amidohydrolase family Pkinase PF00069.20 ESL10075.1 - 9.1e-65 218.3 0.0 1e-64 218.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10075.1 - 2e-31 108.9 0.0 2.6e-31 108.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10075.1 - 6.9e-07 28.5 0.0 8.7e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESL10075.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESL10075.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MOZ_SAS PF01853.13 ESL10077.1 - 9.3e-23 80.4 0.0 1.3e-21 76.6 0.0 2.2 1 1 0 1 1 1 1 MOZ/SAS family WW PF00397.21 ESL10078.1 - 1.2e-07 31.4 0.1 2.1e-07 30.6 0.1 1.4 1 0 0 1 1 1 1 WW domain NUDIX-like PF09296.6 ESL10078.1 - 0.57 10.5 7.4 3.6 7.9 2.9 2.8 2 1 0 2 2 2 0 NADH pyrophosphatase-like rudimentary NUDIX domain APG6 PF04111.7 ESL10078.1 - 2.5 7.0 65.7 4 6.3 16.9 3.2 1 1 1 3 3 3 0 Autophagy protein Apg6 CsgE PF10627.4 ESL10078.1 - 5 6.9 8.8 0.77 9.6 2.1 2.4 2 1 0 2 2 2 0 Curli assembly protein CsgE DUF4458 PF14660.1 ESL10079.1 - 0.032 14.2 2.3 0.12 12.3 0.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4458) UCH PF00443.24 ESL10080.1 - 2.6e-46 157.9 0.0 3.8e-46 157.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL10080.1 - 1.2e-16 61.0 0.0 1.8e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Plasmodium_Vir PF05795.6 ESL10080.1 - 0.58 9.2 1.2 1 8.5 0.8 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2870 PF11069.3 ESL10081.1 - 4.8e-25 87.4 0.0 1.1e-24 86.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) DUF2009 PF09418.5 ESL10082.1 - 5.9e-114 381.3 0.0 1.4e-112 376.8 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2009) EF-hand_7 PF13499.1 ESL10083.1 - 1.2e-20 73.3 0.6 8.8e-12 44.9 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL10083.1 - 4e-20 71.1 1.1 1.2e-06 28.0 0.1 4.0 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 ESL10083.1 - 1.1e-17 61.8 1.4 1.6e-07 30.0 0.1 5.0 5 1 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 ESL10083.1 - 1.5e-15 55.6 0.2 5.3e-06 25.8 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 ESL10083.1 - 3.5e-07 29.2 4.0 0.00028 20.0 0.0 4.4 3 2 1 4 4 4 1 EF hand EF-hand_9 PF14658.1 ESL10083.1 - 3.7e-07 29.9 0.0 1e-05 25.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.2 ESL10083.1 - 0.0052 16.4 0.1 0.024 14.3 0.1 1.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESL10083.1 - 0.025 14.5 0.0 0.066 13.2 0.1 1.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.5 ESL10083.1 - 0.038 13.9 0.7 0.099 12.6 0.0 2.1 3 0 0 3 3 3 0 Ca2+ insensitive EF hand DUF1014 PF06244.7 ESL10083.1 - 0.087 13.0 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1014) Dynein_light PF01221.13 ESL10084.1 - 2.7e-30 104.2 0.0 3.2e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 EF-hand_9 PF14658.1 ESL10085.1 - 2.1e-21 75.5 0.1 4e-20 71.4 0.0 2.3 2 1 1 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 ESL10085.1 - 8.4e-13 48.2 0.1 5.2e-05 23.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL10085.1 - 2.5e-10 38.9 0.9 0.00085 18.4 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 ESL10085.1 - 2.7e-07 29.8 0.3 0.0017 18.0 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 ESL10085.1 - 7.4e-05 22.2 1.9 2.8 7.6 0.1 3.8 3 1 1 4 4 4 2 EF-hand domain pair EFhand_Ca_insen PF08726.5 ESL10085.1 - 0.01 15.7 0.2 0.023 14.6 0.1 1.6 1 1 0 1 1 1 0 Ca2+ insensitive EF hand EF-hand_like PF09279.6 ESL10085.1 - 0.017 15.0 0.0 17 5.4 0.0 3.0 2 1 1 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like Nsp1 PF11501.3 ESL10085.1 - 0.081 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Non structural protein Nsp1 Ras PF00071.17 ESL10086.1 - 5e-61 204.8 0.2 5.8e-61 204.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL10086.1 - 8.4e-19 68.2 0.0 1.5e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL10086.1 - 4.9e-14 51.9 0.1 5.8e-14 51.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL10086.1 - 2.8e-07 29.9 0.0 3.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESL10086.1 - 0.00011 21.6 0.1 0.00034 20.1 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL10086.1 - 0.00031 20.6 0.0 0.00048 20.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESL10086.1 - 0.02 15.0 0.0 0.043 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESL10086.1 - 0.033 13.3 0.1 0.066 12.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 HTS PF04204.11 ESL10086.1 - 0.039 12.6 0.0 0.052 12.2 0.0 1.1 1 0 0 1 1 1 0 Homoserine O-succinyltransferase SRPRB PF09439.5 ESL10086.1 - 0.043 13.0 0.0 0.09 11.9 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ESL10086.1 - 0.047 13.6 0.0 0.085 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.1 ESL10086.1 - 0.048 13.2 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESL10086.1 - 0.12 11.8 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 ESL10086.1 - 0.14 12.4 1.1 0.68 10.2 0.8 2.1 1 1 0 1 1 1 0 ABC transporter DUF4586 PF15239.1 ESL10087.1 - 4.4e-36 124.9 1.3 5.3e-36 124.7 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF3878 PF12994.2 ESL10088.1 - 0.026 13.6 0.4 0.035 13.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3878) DUF4109 PF13397.1 ESL10088.1 - 0.03 14.7 0.1 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4109) DUF4512 PF14975.1 ESL10088.1 - 0.082 13.7 0.1 0.15 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) Glyco_transf_22 PF03901.12 ESL10089.1 - 4.5e-61 207.1 12.0 1.1e-60 205.8 8.3 1.6 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family DJ-1_PfpI PF01965.19 ESL10090.1 - 5.3e-27 94.0 0.1 6.9e-27 93.7 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 ESL10090.1 - 1.3e-12 47.2 0.0 1.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase IncA PF04156.9 ESL10093.1 - 0.0045 16.6 6.4 0.0067 16.0 4.5 1.2 1 0 0 1 1 1 1 IncA protein Xpo1 PF08389.7 ESL10093.1 - 0.096 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Exportin 1-like protein SNARE PF05739.14 ESL10095.1 - 8.8e-06 25.3 0.8 2.6e-05 23.8 0.5 1.6 1 1 0 1 1 1 1 SNARE domain WW PF00397.21 ESL10097.1 - 2.4e-10 40.0 1.3 2.4e-10 40.0 0.9 1.8 2 0 0 2 2 2 1 WW domain WD40 PF00400.27 ESL10098.1 - 1.9e-20 71.9 18.3 1.7e-07 30.8 0.1 6.1 7 0 0 7 7 6 4 WD domain, G-beta repeat ATG16 PF08614.6 ESL10098.1 - 0.017 14.9 16.5 0.1 12.4 4.8 2.9 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) HALZ PF02183.13 ESL10098.1 - 0.018 14.7 9.6 0.79 9.4 0.4 3.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper DivIC PF04977.10 ESL10098.1 - 0.057 12.9 6.9 0.13 11.7 0.8 2.7 2 0 0 2 2 2 0 Septum formation initiator DUF2058 PF09831.4 ESL10098.1 - 0.12 12.3 3.6 3.4 7.5 4.3 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) Kinetocho_Slk19 PF12709.2 ESL10098.1 - 0.14 12.2 8.3 0.73 9.9 0.6 2.9 3 1 0 3 3 3 0 Central kinetochore-associated DUF1640 PF07798.6 ESL10098.1 - 0.14 12.1 9.2 3.3 7.7 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Striatin PF08232.7 ESL10098.1 - 1.1 9.5 12.6 0.18 12.0 3.3 2.6 2 0 0 2 2 2 0 Striatin family APG6 PF04111.7 ESL10098.1 - 5.5 5.9 12.4 0.95 8.4 3.5 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Nnf1 PF03980.9 ESL10098.1 - 6.5 6.7 14.1 3.1 7.8 3.9 3.7 3 1 1 4 4 4 0 Nnf1 Mnd1 PF03962.10 ESL10098.1 - 7.9 6.0 14.3 2.8 7.5 3.2 2.3 2 0 0 2 2 2 0 Mnd1 family IncA PF04156.9 ESL10098.1 - 8.6 5.9 16.9 7.5 6.0 4.1 2.5 2 1 0 2 2 2 0 IncA protein CDP-OH_P_transf PF01066.16 ESL10101.1 - 6.9e-24 84.0 0.6 6.9e-24 84.0 0.4 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase WD40 PF00400.27 ESL10102.1 - 2.8e-31 106.2 4.8 1.7e-08 34.0 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESL10102.1 - 0.21 9.6 0.2 2.4 6.1 0.0 2.4 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Exc PF07825.6 ESL10103.1 - 0.049 13.3 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Excisionase-like protein DAGK_acc PF00609.14 ESL10104.1 - 6e-28 98.0 0.0 1.9e-27 96.4 0.0 1.8 1 1 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 ESL10104.1 - 4.7e-08 32.5 0.2 1.6e-07 30.7 0.1 1.9 1 1 1 2 2 2 1 Diacylglycerol kinase catalytic domain APG6 PF04111.7 ESL10106.1 - 0.00077 18.5 6.5 0.00077 18.5 4.5 4.9 4 1 0 5 5 5 2 Autophagy protein Apg6 IncA PF04156.9 ESL10106.1 - 0.0077 15.8 5.9 0.0077 15.8 4.1 4.6 4 1 0 4 4 4 2 IncA protein DUF4479 PF14794.1 ESL10106.1 - 0.09 12.3 3.3 10 5.7 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4479) Mnd1 PF03962.10 ESL10106.1 - 0.64 9.6 30.5 0.36 10.4 2.0 5.2 5 0 0 5 5 5 0 Mnd1 family DUF1664 PF07889.7 ESL10106.1 - 5.3 6.8 16.4 3.6 7.4 0.0 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) BRCT PF00533.21 ESL10108.1 - 4.6e-06 26.6 0.0 0.0074 16.4 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DZR PF12773.2 ESL10108.1 - 0.028 14.2 0.5 0.083 12.7 0.3 1.7 1 0 0 1 1 1 0 Double zinc ribbon PDH PF02153.12 ESL10108.1 - 0.071 11.9 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 Prephenate dehydrogenase eRF1_2 PF03464.10 ESL10109.1 - 9.5e-40 136.0 0.0 2.9e-39 134.4 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.10 ESL10109.1 - 3.7e-37 127.0 0.3 5.7e-37 126.4 0.2 1.3 1 0 0 1 1 1 1 eRF1 domain 3 VanY PF02557.12 ESL10109.1 - 0.087 12.6 0.0 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Metallophos PF00149.23 ESL10110.1 - 5.8e-11 42.1 0.0 2.2e-10 40.2 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL10110.1 - 6.2e-07 29.3 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Dpy-30 PF05186.8 ESL10111.1 - 2.2e-07 30.2 0.1 3.7e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Dpy-30 motif F-box-like_2 PF13013.1 ESL10111.1 - 0.03 14.0 1.5 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 F-box-like domain FIVAR PF07554.8 ESL10111.1 - 0.49 10.6 3.5 0.31 11.3 0.4 2.1 2 0 0 2 2 2 0 Uncharacterised Sugar-binding Domain Polyketide_cyc PF03364.15 ESL10112.1 - 4e-14 52.7 0.3 7.8e-14 51.7 0.2 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AAA PF00004.24 ESL10114.1 - 1.6e-10 41.2 0.0 1.4e-09 38.2 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESL10114.1 - 0.015 15.0 0.0 0.04 13.6 0.0 1.7 2 0 0 2 2 2 0 Part of AAA domain AAA_11 PF13086.1 ESL10114.1 - 0.019 14.5 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL10114.1 - 0.043 13.6 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL10114.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESL10114.1 - 0.073 13.8 0.0 0.13 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESL10114.1 - 0.11 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus NACHT PF05729.7 ESL10114.1 - 0.13 11.9 0.1 2.5 7.7 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_22 PF13401.1 ESL10114.1 - 0.15 12.1 0.0 0.38 10.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESL10114.1 - 0.17 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Dynein_light PF01221.13 ESL10115.1 - 3.4e-36 123.1 0.6 3.7e-36 122.9 0.4 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 adh_short PF00106.20 ESL10116.1 - 1.1e-37 129.5 6.4 1.7e-37 128.9 4.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESL10116.1 - 7.2e-22 77.9 4.2 1.1e-21 77.3 2.9 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESL10116.1 - 2.2e-19 70.2 0.0 3e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESL10116.1 - 6.8e-07 29.4 0.9 2.9e-06 27.4 0.6 1.9 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESL10116.1 - 3.4e-05 23.3 0.5 0.00013 21.5 0.4 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 ESL10116.1 - 0.00088 18.2 0.5 0.0014 17.6 0.4 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESL10116.1 - 0.0037 16.0 0.2 0.0051 15.5 0.2 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Eno-Rase_NADH_b PF12242.3 ESL10116.1 - 0.0079 15.9 0.2 0.02 14.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_7 PF13241.1 ESL10116.1 - 0.044 14.0 0.9 0.081 13.1 0.3 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Glyco_transf_4 PF13439.1 ESL10116.1 - 0.07 12.8 0.8 0.43 10.2 0.1 2.4 3 0 0 3 3 3 0 Glycosyltransferase Family 4 6PGD PF00393.14 ESL10117.1 - 5.3e-88 295.0 0.0 1.1e-87 294.0 0.0 1.5 2 0 0 2 2 2 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 ESL10117.1 - 1.2e-45 155.2 0.7 2.1e-45 154.4 0.5 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 ESL10117.1 - 6.6e-06 26.2 0.5 2.3e-05 24.5 0.3 1.9 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 ESL10117.1 - 8.7e-06 26.0 0.7 2.1e-05 24.8 0.5 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 ESL10117.1 - 8.8e-06 25.4 0.3 1.6e-05 24.6 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 ESL10117.1 - 0.00012 21.8 0.2 0.00023 20.9 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 ESL10117.1 - 0.00013 21.4 0.1 0.00023 20.6 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DAO PF01266.19 ESL10117.1 - 0.00025 20.0 0.0 0.0004 19.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_11 PF14833.1 ESL10117.1 - 0.0024 17.9 0.1 0.0059 16.6 0.0 1.7 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.14 ESL10117.1 - 0.0047 16.1 0.2 0.011 14.8 0.2 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thi4 PF01946.12 ESL10117.1 - 0.0066 15.5 1.1 0.11 11.6 0.1 2.8 3 0 0 3 3 3 1 Thi4 family TrkA_N PF02254.13 ESL10117.1 - 0.022 14.7 0.5 0.04 13.9 0.4 1.4 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.9 ESL10117.1 - 0.024 14.0 0.3 0.048 13.0 0.2 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.7 ESL10117.1 - 0.038 13.3 0.1 0.066 12.5 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Pyr_redox_2 PF07992.9 ESL10117.1 - 0.1 12.4 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_18 PF12847.2 ESL10118.1 - 0.0015 19.1 0.0 0.0026 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.6 ESL10118.1 - 0.021 14.4 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase DUF904 PF06005.7 ESL10119.1 - 0.057 13.7 3.0 6.6 7.0 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF904) MscS_porin PF12795.2 ESL10119.1 - 0.29 10.4 7.5 3 7.0 3.0 2.4 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF563 PF04577.9 ESL10120.1 - 0.00023 21.1 1.0 0.00057 19.8 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF563) Pox_MCEL PF03291.11 ESL10121.1 - 2.1e-34 118.9 0.0 4.1e-23 81.7 0.0 2.2 2 0 0 2 2 2 2 mRNA capping enzyme Methyltransf_12 PF08242.7 ESL10121.1 - 0.00011 22.5 0.0 0.00024 21.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10121.1 - 0.0029 18.1 0.1 0.0057 17.2 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 ESL10121.1 - 0.0065 15.4 0.1 0.012 14.5 0.1 1.4 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_11 PF08241.7 ESL10121.1 - 0.0067 16.8 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10121.1 - 0.039 13.5 0.0 0.31 10.6 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Euplotes_phero PF05842.6 ESL10121.1 - 0.044 14.1 2.7 0.1 12.9 1.8 1.5 1 0 0 1 1 1 0 Euplotes octocarinatus mating pheromone protein Metallophos PF00149.23 ESL10122.1 - 1.5e-37 128.9 0.1 2e-37 128.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Aminotran_1_2 PF00155.16 ESL10123.1 - 1.7e-78 264.1 0.0 1.9e-78 263.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 ESL10123.1 - 0.00022 20.4 0.0 0.076 12.0 0.0 2.1 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 ESL10123.1 - 0.00039 19.2 0.0 0.00088 18.1 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESL10123.1 - 0.00084 18.5 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.2 ESL10123.1 - 0.0047 15.5 0.0 0.007 14.9 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Cys_Met_Meta_PP PF01053.15 ESL10123.1 - 0.0072 14.6 0.0 0.011 14.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Prp19 PF08606.6 ESL10125.1 - 3.4e-27 93.9 0.0 8.3e-27 92.7 0.0 1.7 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.27 ESL10125.1 - 3.5e-13 48.8 11.8 0.0012 18.6 0.0 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat zf-Nse PF11789.3 ESL10125.1 - 0.0058 16.1 0.8 0.011 15.1 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PBC PF03792.8 ESL10125.1 - 0.088 12.4 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 PBC domain Rtf2 PF04641.7 ESL10125.1 - 0.17 11.0 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1301 PF06979.7 ESL10126.1 - 0.019 15.0 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1301) Complex1_LYR_1 PF13232.1 ESL10126.1 - 0.089 13.0 0.4 0.16 12.1 0.3 1.5 1 0 0 1 1 1 0 Complex1_LYR-like Metallophos PF00149.23 ESL10127.1 - 6.7e-29 100.7 0.1 1e-28 100.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL10127.1 - 0.0001 22.1 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Plus-3 PF03126.13 ESL10127.1 - 0.0017 18.3 0.0 0.0037 17.2 0.0 1.6 1 0 0 1 1 1 1 Plus-3 domain NDK PF00334.14 ESL10128.1 - 8.7e-37 125.9 0.0 1e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase E_Pc_C PF06752.7 ESL10129.1 - 0.073 12.5 0.7 0.11 11.9 0.5 1.2 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus DUF2054 PF10218.4 ESL10130.1 - 0.01 15.6 0.6 0.015 15.1 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2054) DUF3279 PF11682.3 ESL10130.1 - 0.012 15.1 0.9 0.018 14.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) zinc-ribbons_6 PF07191.7 ESL10130.1 - 0.015 15.0 1.9 0.034 13.9 1.3 1.6 1 0 0 1 1 1 0 zinc-ribbons DUF2614 PF11023.3 ESL10130.1 - 0.092 12.5 0.2 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2614) ABC_transp_aux PF09822.4 ESL10132.1 - 4.2e-05 23.1 0.0 6.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DUF1355 PF07090.6 ESL10132.1 - 6.5e-05 22.3 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1355) ThuA PF06283.6 ESL10132.1 - 0.0062 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Trehalose utilisation DUF4159 PF13709.1 ESL10132.1 - 0.058 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) DNA_topoisoIV PF00521.15 ESL10133.1 - 3.5e-99 332.5 0.0 1e-98 330.9 0.0 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A Toprim PF01751.17 ESL10133.1 - 9.9e-12 44.7 0.0 3.9e-11 42.8 0.0 2.1 1 0 0 1 1 1 1 Toprim domain DNA_gyraseB PF00204.20 ESL10133.1 - 3.8e-11 42.5 0.0 8.5e-11 41.3 0.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 ESL10133.1 - 1.1e-06 28.2 0.0 2.5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESL10133.1 - 1.6e-05 24.5 0.0 4.1e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3045 PF11243.3 ESL10133.1 - 0.084 13.1 0.1 0.28 11.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3045) Trypsin_2 PF13365.1 ESL10134.1 - 0.0021 18.0 0.0 0.0044 16.9 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF4096 PF13340.1 ESL10134.1 - 0.014 15.1 0.3 0.047 13.5 0.2 1.9 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) U79_P34 PF03064.11 ESL10135.1 - 2.5 7.5 12.6 2.9 7.3 8.7 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 CtaG_Cox11 PF04442.9 ESL10137.1 - 2.6e-45 153.9 0.1 3.3e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 tRNA-synt_2b PF00587.20 ESL10138.1 - 1.2e-54 184.4 0.0 2.3e-54 183.5 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESL10138.1 - 1.3e-16 60.2 0.0 3.4e-16 58.9 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain CTDII PF01556.13 ESL10139.1 - 6.3e-22 77.2 0.1 4.3e-21 74.6 0.0 2.2 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.26 ESL10139.1 - 1.4e-19 69.5 1.0 2.4e-19 68.7 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESL10139.1 - 7.9e-16 57.8 11.3 1.4e-15 57.1 7.8 1.4 1 0 0 1 1 1 1 DnaJ central domain DUF3875 PF12991.2 ESL10139.1 - 0.028 14.0 0.0 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3875) Ogr_Delta PF04606.7 ESL10139.1 - 0.046 13.3 1.4 5.6 6.7 0.1 2.6 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger HypA PF01155.14 ESL10139.1 - 0.052 13.2 3.8 0.12 12.0 0.1 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF4206 PF13901.1 ESL10139.1 - 0.13 11.8 1.3 0.21 11.1 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Lar_restr_allev PF14354.1 ESL10139.1 - 2.9 8.2 9.1 6.8 7.0 1.3 3.1 2 1 2 4 4 4 0 Restriction alleviation protein Lar zf-TFIIB PF13453.1 ESL10139.1 - 6.6 6.0 10.0 19 4.5 0.1 3.0 2 1 2 4 4 4 0 Transcription factor zinc-finger UPF0029 PF01205.14 ESL10140.1 - 1.3e-28 98.8 0.0 2.2e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 ESL10140.1 - 1.1e-07 31.6 0.0 2.3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 RWD domain Steroid_dh PF02544.11 ESL10141.1 - 7.1e-36 123.2 0.3 2.1e-35 121.6 0.2 1.8 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 ESL10141.1 - 5.9e-08 32.3 0.1 1.1e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Tcf25 PF04910.9 ESL10142.1 - 1.5e-68 231.3 0.0 2.2e-68 230.8 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Tubulin PF00091.20 ESL10143.1 - 1.7e-66 224.1 0.0 1.9e-66 223.9 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.4 ESL10143.1 - 1.1e-05 25.4 0.0 1.6e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESL10143.1 - 0.00074 19.0 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.1 ESL10143.1 - 0.15 10.9 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Ist1 PF03398.9 ESL10144.1 - 1.9e-58 196.5 0.1 2.3e-58 196.2 0.1 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Mtc PF03820.12 ESL10145.1 - 1.4e-22 79.7 0.0 1.8e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier zf-HC5HC2H_2 PF13832.1 ESL10146.1 - 3e-07 30.4 11.1 3e-07 30.4 7.7 2.8 1 1 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 ESL10146.1 - 3.7e-06 27.0 10.4 3.7e-06 27.0 7.2 3.1 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD PF00628.24 ESL10146.1 - 0.0015 18.2 9.8 0.0015 18.2 6.8 2.9 2 0 0 2 2 2 1 PHD-finger AT_hook PF02178.14 ESL10146.1 - 6.6 6.7 11.6 15 5.6 0.4 3.0 2 0 0 2 2 2 0 AT hook motif HSP33 PF01430.14 ESL10147.1 - 0.00015 20.9 0.0 0.0097 15.0 0.0 2.1 2 0 0 2 2 2 2 Hsp33 protein Pro_isomerase PF00160.16 ESL10148.1 - 0.00013 22.2 0.0 0.00025 21.3 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-DHHC PF01529.15 ESL10149.1 - 1.1e-36 125.8 6.7 1.1e-36 125.8 4.6 1.7 1 1 1 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.1 ESL10149.1 - 0.087 12.6 0.1 0.087 12.6 0.1 1.6 2 0 0 2 2 2 0 Transglutaminase-like superfamily PSI PF01437.20 ESL10149.1 - 0.24 11.5 12.3 0.48 10.6 2.3 2.5 2 0 0 2 2 2 0 Plexin repeat MNHE PF01899.11 ESL10149.1 - 9 5.9 6.6 5.6 6.5 0.5 2.2 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit DUF805 PF05656.9 ESL10149.1 - 9.4 6.0 8.2 4.9 7.0 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DNA_pol_E_B PF04042.11 ESL10150.1 - 3e-29 101.7 0.1 5.5e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B 4HBT PF03061.17 ESL10151.1 - 0.013 15.5 0.1 0.023 14.8 0.1 1.3 1 0 0 1 1 1 0 Thioesterase superfamily DUF1174 PF06671.6 ESL10151.1 - 0.048 13.3 1.9 0.11 12.1 1.3 1.6 1 0 0 1 1 1 0 Repeat of unknown function (DUF1174) Peptidase_M24 PF00557.19 ESL10153.1 - 1.3e-34 119.5 0.2 1.6e-34 119.3 0.2 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 Transketolase_N PF00456.16 ESL10154.1 - 3.8e-134 446.7 0.0 5.2e-134 446.2 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 ESL10154.1 - 6.5e-42 143.0 0.0 1.1e-41 142.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESL10154.1 - 1.9e-07 31.0 0.0 5.2e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 ESL10154.1 - 0.018 13.9 0.0 0.082 11.8 0.0 2.0 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase DUF3773 PF12608.3 ESL10155.1 - 5.6e-19 67.9 0.5 1.4e-18 66.6 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3773) GTP_EFTU_D3 PF03143.12 ESL10157.1 - 1.1e-36 124.9 0.1 9.2e-36 121.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL10157.1 - 2.8e-18 65.7 0.6 2.8e-18 65.7 0.4 1.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 ESL10157.1 - 5.7e-06 25.8 0.1 1.5e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.13 ESL10157.1 - 0.0042 16.9 0.2 0.098 12.4 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, dimerisation domain DUF1456 PF07308.8 ESL10158.1 - 0.0021 18.0 0.8 0.0021 18.0 0.6 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1456) EST1 PF10374.4 ESL10158.1 - 0.016 15.1 1.2 0.031 14.2 0.1 2.2 2 1 0 2 2 2 0 Telomerase activating protein Est1 MbeD_MobD PF04899.7 ESL10158.1 - 0.27 11.1 3.9 3.7 7.5 0.1 3.8 3 1 0 3 3 3 0 MbeD/MobD like FlaC_arch PF05377.6 ESL10158.1 - 0.47 10.3 4.0 4.1 7.3 0.0 3.9 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF4164 PF13747.1 ESL10158.1 - 1.4 9.1 18.7 10 6.3 5.6 4.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) CAF1A PF12253.3 ESL10159.1 - 6.4e-05 22.9 18.8 6.4e-05 22.9 13.0 3.7 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A SDA1 PF05285.7 ESL10159.1 - 9.1 5.4 26.3 0.18 11.0 8.4 3.1 3 0 0 3 3 3 0 SDA1 DUF2404 PF10296.4 ESL10162.1 - 8.6e-22 77.0 0.0 1.7e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Zip PF02535.17 ESL10162.1 - 0.03 13.3 5.8 0.051 12.5 4.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Lipase_3 PF01764.20 ESL10163.1 - 9.2e-15 54.4 0.0 1.5e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) WD40 PF00400.27 ESL10164.1 - 3.4e-08 33.0 10.3 0.033 14.0 1.2 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat Beta_helix PF13229.1 ESL10165.1 - 1.9e-20 73.2 2.9 2.4e-11 43.6 1.0 2.3 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.8 ESL10165.1 - 7.4e-12 44.9 0.0 1e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.2 ESL10165.1 - 0.007 16.5 0.6 1.4 8.9 0.2 2.1 1 1 1 2 2 2 2 Pectate lyase superfamily protein ThiS-like PF14453.1 ESL10165.1 - 0.013 15.2 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 ThiS-like ubiquitin DUF1565 PF07602.6 ESL10165.1 - 0.025 13.7 0.3 1.2 8.1 0.2 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1565) DUF4353 PF14262.1 ESL10165.1 - 0.038 13.2 1.0 0.067 12.3 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4353) Pectinesterase PF01095.14 ESL10165.1 - 0.1 11.1 0.2 0.16 10.4 0.1 1.4 1 0 0 1 1 1 0 Pectinesterase Hexapep PF00132.19 ESL10165.1 - 0.19 11.2 2.1 0.55 9.8 0.0 2.9 4 0 0 4 4 4 0 Bacterial transferase hexapeptide (six repeats) E1-E2_ATPase PF00122.15 ESL10166.1 - 3.7e-24 85.0 0.7 1.1e-23 83.4 0.0 2.1 3 0 0 3 3 3 1 E1-E2 ATPase HAD PF12710.2 ESL10166.1 - 7.4e-21 75.1 0.0 1.4e-20 74.2 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESL10166.1 - 5.6e-17 62.8 0.0 5.3e-16 59.6 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL10166.1 - 2.1e-06 27.5 0.0 4.5e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESL10166.1 - 0.0078 15.8 0.3 0.036 13.6 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Oxidored-like PF09791.4 ESL10169.1 - 8.1e-13 47.6 2.9 1.5e-12 46.7 2.0 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal KR PF08659.5 ESL10169.1 - 0.14 11.8 0.0 0.21 11.2 0.0 1.1 1 0 0 1 1 1 0 KR domain ERG4_ERG24 PF01222.12 ESL10171.1 - 4.6e-131 437.3 6.2 5.4e-131 437.0 4.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 ESL10171.1 - 1.4e-08 34.3 0.1 5e-08 32.5 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 ESL10171.1 - 8.5e-05 22.6 0.0 8.5e-05 22.6 0.0 2.3 3 0 0 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.9 ESL10171.1 - 0.0096 16.0 1.0 0.023 14.8 0.0 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family TBPIP PF07106.8 ESL10172.1 - 0.0029 17.1 1.3 0.0029 17.1 0.9 5.9 3 1 3 6 6 6 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIC PF04977.10 ESL10172.1 - 0.0058 16.0 2.2 0.0058 16.0 1.5 7.3 5 1 3 8 8 8 1 Septum formation initiator DUF4200 PF13863.1 ESL10172.1 - 0.0059 16.5 8.0 0.0059 16.5 5.5 6.9 5 3 2 7 7 7 1 Domain of unknown function (DUF4200) WD40_alt PF14077.1 ESL10172.1 - 0.72 9.5 8.5 0.097 12.3 2.2 2.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif GMC_oxred_N PF00732.14 ESL10173.1 - 3.9e-16 59.0 0.0 5.2e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 ESL10173.1 - 4.6e-07 29.0 1.9 4.7e-06 25.7 1.3 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase GMC_oxred_C PF05199.8 ESL10173.1 - 1.4e-05 25.3 0.0 0.00035 20.8 0.0 2.3 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 ESL10173.1 - 4.6e-05 22.4 0.1 0.087 11.6 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.14 ESL10173.1 - 0.0012 17.9 0.1 0.09 11.8 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 ESL10173.1 - 0.0012 18.7 0.0 0.0032 17.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 ESL10173.1 - 0.0021 18.1 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESL10173.1 - 0.005 15.8 0.0 0.064 12.1 0.0 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 ESL10173.1 - 0.013 15.2 0.1 5.6 6.7 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 ESL10173.1 - 0.023 15.1 0.1 0.091 13.1 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESL10173.1 - 0.054 13.3 0.0 3.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ESL10173.1 - 0.068 11.6 0.1 2.6 6.4 0.0 2.7 3 0 0 3 3 3 0 HI0933-like protein DUF577 PF04510.7 ESL10174.1 - 0.023 14.4 0.1 0.051 13.2 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF577) DUF4259 PF14078.1 ESL10174.1 - 0.83 10.1 6.7 0.63 10.5 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) Rep_fac-A_3 PF08661.6 ESL10175.1 - 9.4e-10 38.3 0.0 1.1e-09 38.1 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 LmjF365940-deam PF14421.1 ESL10176.1 - 8.1e-41 139.5 0.0 3.3e-19 69.0 0.0 2.3 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.17 ESL10176.1 - 0.05 13.2 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region zf-CCCH PF00642.19 ESL10176.1 - 0.055 13.1 2.2 0.16 11.6 1.5 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Seryl_tRNA_N PF02403.17 ESL10177.1 - 0.0024 17.8 8.4 0.01 15.8 0.8 2.7 2 1 0 3 3 2 1 Seryl-tRNA synthetase N-terminal domain AAA_13 PF13166.1 ESL10177.1 - 0.04 12.3 3.7 0.057 11.8 2.5 1.2 1 0 0 1 1 1 0 AAA domain MscS_porin PF12795.2 ESL10177.1 - 0.042 13.1 4.5 0.15 11.3 0.2 2.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain EzrA PF06160.7 ESL10177.1 - 0.045 11.9 6.1 0.06 11.5 4.2 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Noelin-1 PF12308.3 ESL10177.1 - 0.067 12.9 5.0 0.072 12.8 0.1 2.7 1 1 1 3 3 3 0 Neurogenesis glycoprotein BRE1 PF08647.6 ESL10177.1 - 0.1 12.5 5.8 0.15 12.0 3.1 2.0 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase ADIP PF11559.3 ESL10177.1 - 0.11 12.4 8.5 0.085 12.7 3.0 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 ESL10177.1 - 0.12 11.4 2.5 1.8 7.6 0.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 ESL10177.1 - 0.14 9.4 9.8 0.32 8.2 6.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) TBPIP PF07106.8 ESL10177.1 - 0.17 11.4 9.0 0.37 10.3 3.1 2.4 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Laminin_I PF06008.9 ESL10177.1 - 0.18 11.0 9.9 0.083 12.1 3.3 2.2 1 1 1 2 2 2 0 Laminin Domain I Atg14 PF10186.4 ESL10177.1 - 0.21 10.5 10.7 0.32 9.9 4.5 2.3 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Laminin_II PF06009.7 ESL10177.1 - 0.25 11.0 6.5 3 7.5 1.4 2.6 1 1 1 2 2 2 0 Laminin Domain II WEMBL PF05701.6 ESL10177.1 - 0.26 9.7 13.2 1 7.7 9.1 1.8 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Ead_Ea22 PF13935.1 ESL10177.1 - 0.33 11.2 10.1 0.1 12.9 4.0 2.1 1 1 1 2 2 2 0 Ead/Ea22-like protein DUF4201 PF13870.1 ESL10177.1 - 0.37 10.1 8.9 0.42 10.0 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) MitMem_reg PF13012.1 ESL10177.1 - 0.38 10.8 2.8 7.1 6.7 0.0 3.2 2 1 0 3 3 3 0 Maintenance of mitochondrial structure and function ATG16 PF08614.6 ESL10177.1 - 0.38 10.5 13.2 0.11 12.2 1.1 3.1 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) IncA PF04156.9 ESL10177.1 - 0.51 9.9 13.5 18 4.8 9.4 2.5 1 1 0 1 1 1 0 IncA protein TMCO5 PF14992.1 ESL10177.1 - 0.51 9.4 9.5 1.8 7.6 6.5 1.8 1 1 0 1 1 1 0 TMCO5 family AAA_23 PF13476.1 ESL10177.1 - 0.57 10.4 2.4 3.2 8.0 1.6 2.1 1 1 0 1 1 1 0 AAA domain IFT57 PF10498.4 ESL10177.1 - 0.61 8.7 7.6 3 6.5 1.1 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 TPR_MLP1_2 PF07926.7 ESL10177.1 - 0.74 9.5 10.7 15 5.3 6.2 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.3 ESL10177.1 - 0.74 9.0 11.9 0.26 10.4 0.8 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.14 ESL10177.1 - 0.76 7.5 3.7 1 7.1 2.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HisKA PF00512.20 ESL10177.1 - 0.76 9.8 4.1 2.2 8.3 0.1 3.1 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain GAS PF13851.1 ESL10177.1 - 0.86 8.7 8.5 1 8.5 4.2 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Cluap1 PF10234.4 ESL10177.1 - 1.1 8.4 11.1 1 8.5 0.7 2.9 1 1 1 2 2 2 0 Clusterin-associated protein-1 DUF4200 PF13863.1 ESL10177.1 - 1.4 8.8 13.4 1 9.3 1.1 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.4 ESL10177.1 - 1.4 8.7 15.0 2.8 7.7 7.9 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin_2 PF01920.15 ESL10177.1 - 1.5 8.5 10.0 16 5.2 0.3 3.2 2 1 1 3 3 3 0 Prefoldin subunit COG2 PF06148.6 ESL10177.1 - 1.6 8.6 10.2 14 5.5 0.6 3.2 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Prominin PF05478.6 ESL10177.1 - 3.1 5.2 9.1 3.3 5.1 0.3 2.3 1 1 2 3 3 3 0 Prominin Mod_r PF07200.8 ESL10177.1 - 3.6 7.4 11.0 1.2 9.0 1.3 2.6 1 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein GrpE PF01025.14 ESL10177.1 - 4.7 6.7 11.3 2.7 7.5 1.0 2.5 1 1 1 2 2 2 0 GrpE DUF904 PF06005.7 ESL10177.1 - 5.5 7.3 13.1 7.1 7.0 0.9 3.0 2 1 1 3 3 2 0 Protein of unknown function (DUF904) THOC7 PF05615.8 ESL10177.1 - 6.8 6.9 15.0 2.8 8.1 1.6 3.2 1 1 2 3 3 3 0 Tho complex subunit 7 KxDL PF10241.4 ESL10177.1 - 7.6 6.5 8.1 48 3.9 0.1 3.3 2 1 1 3 3 3 0 Uncharacterized conserved protein Vault PF01505.13 ESL10179.1 - 1.4e-44 149.8 0.1 2.3e-13 49.9 0.0 4.9 4 0 0 4 4 4 4 Major Vault Protein repeat MVP_shoulder PF11978.3 ESL10179.1 - 7.2e-44 148.4 0.0 1.8e-43 147.2 0.0 1.7 1 0 0 1 1 1 1 Shoulder domain DUF3601 PF12208.3 ESL10179.1 - 0.066 13.1 0.0 0.3 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3601) TPR_11 PF13414.1 ESL10180.1 - 4e-68 224.9 29.8 1e-18 66.6 0.1 6.2 6 0 0 6 6 6 6 TPR repeat TPR_1 PF00515.23 ESL10180.1 - 5.9e-52 171.2 29.7 1.4e-07 30.8 0.1 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10180.1 - 5e-47 154.0 31.8 2.4e-05 23.8 0.4 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESL10180.1 - 1.2e-26 92.7 17.9 2e-07 31.4 0.1 6.6 5 1 2 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.1 ESL10180.1 - 1.6e-21 74.3 16.9 0.004 16.8 0.0 8.6 6 2 2 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 ESL10180.1 - 7.7e-21 73.8 26.6 1.3e-05 25.0 0.8 6.7 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10180.1 - 1.7e-20 71.6 17.4 0.021 15.4 0.1 9.2 5 3 4 9 9 8 6 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10180.1 - 9e-16 57.9 13.0 0.0027 18.0 0.1 6.4 4 2 3 7 7 7 6 Tetratricopeptide repeat TPR_9 PF13371.1 ESL10180.1 - 2e-13 50.0 10.2 0.0001 22.0 0.0 6.3 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESL10180.1 - 7.9e-13 47.1 14.9 0.64 9.9 0.0 8.5 8 1 1 9 9 9 4 Tetratricopeptide repeat Apc3 PF12895.2 ESL10180.1 - 8.8e-12 45.0 25.8 6e-06 26.3 3.9 4.9 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESL10180.1 - 2.9e-09 36.3 21.8 0.05 13.8 0.0 8.9 10 0 0 10 10 9 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL10180.1 - 6.8e-07 29.0 12.1 0.62 9.9 0.1 7.5 7 1 1 8 8 8 2 Fis1 C-terminal tetratricopeptide repeat Coatomer_E PF04733.9 ESL10180.1 - 2.3e-06 27.0 3.9 0.0034 16.6 0.4 3.3 1 1 2 3 3 3 2 Coatomer epsilon subunit TPR_10 PF13374.1 ESL10180.1 - 1.2e-05 25.0 21.0 0.077 12.9 0.2 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10180.1 - 4.5e-05 23.6 21.8 5.7 7.6 0.0 7.8 7 0 0 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESL10180.1 - 9.1e-05 21.6 12.2 1.7 7.9 0.0 6.3 6 0 0 6 6 6 1 SHNi-TPR TPR_20 PF14561.1 ESL10180.1 - 0.0035 17.4 4.6 5.8 7.1 0.3 4.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 ESL10180.1 - 0.0061 16.3 14.8 0.04 13.7 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat NYD-SP12_N PF15015.1 ESL10180.1 - 0.0079 14.4 6.1 0.14 10.3 0.1 2.9 3 0 0 3 3 3 2 Spermatogenesis-associated, N-terminal FadA PF09403.5 ESL10180.1 - 0.023 14.7 22.9 0.23 11.4 8.7 3.5 2 1 1 3 3 3 0 Adhesion protein FadA Phosducin PF02114.11 ESL10181.1 - 1.1e-06 27.5 0.1 1.2e-06 27.4 0.1 1.0 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.15 ESL10181.1 - 8.6e-06 25.3 0.0 1.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.11 ESL10181.1 - 0.0075 15.7 0.2 0.014 14.8 0.1 1.5 1 0 0 1 1 1 1 Mitosis protein DIM1 KaiB PF07689.7 ESL10181.1 - 0.058 12.8 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiB domain Thioredoxin_3 PF13192.1 ESL10181.1 - 0.14 11.9 0.1 0.59 9.9 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin domain EF-hand_6 PF13405.1 ESL10182.1 - 1.8e-06 27.3 1.0 0.006 16.3 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESL10182.1 - 4.7e-06 26.6 0.1 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL10182.1 - 5.8e-06 25.2 0.6 0.013 14.7 0.0 3.2 3 0 0 3 3 3 2 EF hand RIIa PF02197.12 ESL10182.1 - 0.00013 21.2 0.0 0.0026 17.1 0.0 2.3 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit EF-hand_5 PF13202.1 ESL10182.1 - 0.00025 20.2 2.2 0.59 9.5 0.2 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 ESL10182.1 - 0.048 13.2 0.4 7.8 6.2 0.2 2.5 2 1 0 2 2 2 0 EF-hand domain pair UCH PF00443.24 ESL10183.1 - 1.4e-45 155.5 0.0 5.8e-45 153.4 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL10183.1 - 4.3e-16 59.2 2.0 4.9e-15 55.7 1.4 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Phosducin PF02114.11 ESL10184.1 - 1e-10 40.8 0.0 1.9e-10 39.9 0.0 1.4 1 1 1 2 2 2 1 Phosducin Sec31 PF11549.3 ESL10185.1 - 0.51 10.0 2.8 0.59 9.8 0.0 2.4 3 0 0 3 3 3 0 Protein transport protein SEC31 Prefoldin_2 PF01920.15 ESL10186.1 - 1e-11 44.4 3.1 1.3e-11 44.2 2.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit DivIVA PF05103.8 ESL10186.1 - 0.0086 16.1 2.9 0.012 15.7 2.0 1.2 1 0 0 1 1 1 1 DivIVA protein PHY PF00360.15 ESL10186.1 - 0.043 12.9 0.1 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Phytochrome region DUF2681 PF10883.3 ESL10186.1 - 0.099 12.8 1.0 0.7 10.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DivIC PF04977.10 ESL10186.1 - 0.1 12.0 3.9 6.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Septum formation initiator Flg_hook PF02120.11 ESL10186.1 - 0.14 11.8 1.2 0.27 10.9 0.8 1.4 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK R3H-assoc PF13902.1 ESL10186.1 - 0.14 12.0 3.2 0.2 11.6 2.0 1.5 1 1 0 1 1 1 0 R3H-associated N-terminal domain LigB PF02900.13 ESL10186.1 - 0.15 11.0 0.7 0.2 10.6 0.4 1.2 1 1 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase TBPIP PF07106.8 ESL10186.1 - 0.2 11.1 3.4 0.31 10.5 0.7 1.9 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc24 PF08286.6 ESL10186.1 - 0.37 10.5 5.3 6.2 6.5 3.6 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Sec2p PF06428.6 ESL10186.1 - 0.5 10.2 6.3 1.1 9.1 4.3 1.7 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF1192 PF06698.6 ESL10186.1 - 0.78 9.6 5.1 0.29 10.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF4140 PF13600.1 ESL10186.1 - 1.6 9.2 5.0 2.3 8.7 0.7 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4164 PF13747.1 ESL10186.1 - 2.7 8.1 10.5 49 4.1 7.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) OmpH PF03938.9 ESL10186.1 - 3 7.7 8.1 3.9 7.4 5.6 1.2 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Prefoldin PF02996.12 ESL10186.1 - 4.5 6.9 7.9 5.4 6.7 2.1 2.3 1 1 1 2 2 2 0 Prefoldin subunit DUF919 PF06034.6 ESL10187.1 - 0.55 9.8 3.0 3 7.5 0.0 2.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) zf-CCCH PF00642.19 ESL10188.1 - 4.6e-07 29.3 3.1 9.7e-07 28.3 2.2 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UBX PF00789.15 ESL10191.1 - 6.2e-08 32.5 0.0 2e-07 30.9 0.0 1.8 2 0 0 2 2 2 1 UBX domain Thioredoxin_7 PF13899.1 ESL10191.1 - 0.00057 19.8 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like eIF3_subunit PF08597.5 ESL10191.1 - 0.1 12.1 16.8 0.13 11.7 11.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Ycf1 PF05758.7 ESL10191.1 - 0.71 7.5 5.7 0.82 7.3 3.9 1.1 1 0 0 1 1 1 0 Ycf1 eIF-3_zeta PF05091.7 ESL10191.1 - 1.1 7.7 9.0 1.4 7.4 6.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) OmpH PF03938.9 ESL10191.1 - 1.4 8.8 16.1 2.4 8.1 11.2 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DDHD PF02862.12 ESL10191.1 - 3 7.5 6.3 5.1 6.8 4.4 1.4 1 0 0 1 1 1 0 DDHD domain PLRV_ORF5 PF01690.12 ESL10191.1 - 3.1 6.8 8.4 4 6.4 5.8 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein V_ATPase_I PF01496.14 ESL10191.1 - 3.6 5.3 7.5 4.2 5.1 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Asp-B-Hydro_N PF05279.6 ESL10191.1 - 5.9 6.6 17.4 8.1 6.2 12.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BTV_NS2 PF04514.7 ESL10191.1 - 6.1 5.6 14.4 7.8 5.2 10.0 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Paramyxo_ncap PF00973.14 ESL10191.1 - 8.3 4.9 7.5 10 4.6 5.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PRTP PF01366.13 ESL10192.1 - 0.031 12.2 5.5 0.04 11.9 3.8 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein HTH_22 PF13309.1 ESL10192.1 - 0.28 10.9 5.7 0.6 9.9 0.1 2.9 4 0 0 4 4 4 0 HTH domain Exonuc_VII_L PF02601.10 ESL10192.1 - 0.37 9.9 7.0 0.41 9.7 4.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V-ATPase_G PF03179.10 ESL10192.1 - 0.5 10.6 8.7 1.1 9.5 6.0 1.8 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit PCI_Csn8 PF10075.4 ESL10193.1 - 2.4e-11 43.6 0.0 3.2e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 ESL10193.1 - 2.1e-09 37.2 0.0 2.8e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family WD40 PF00400.27 ESL10195.1 - 6.4e-06 25.8 1.5 0.35 10.8 0.1 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Peptidase_M24 PF00557.19 ESL10196.1 - 5.8e-32 110.9 0.5 7.7e-32 110.5 0.4 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 UCR_14kD PF02271.11 ESL10198.1 - 3.4e-09 36.4 0.0 7e-09 35.4 0.0 1.4 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase complex 14kD subunit ABC_membrane_2 PF06472.10 ESL10199.1 - 6.7e-76 255.0 1.3 8.9e-76 254.6 0.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESL10199.1 - 2.9e-16 60.0 0.0 5.6e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL10199.1 - 0.0042 16.3 0.0 1.7 7.8 0.0 2.2 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 ESL10199.1 - 0.015 15.4 0.1 0.073 13.2 0.1 2.3 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESL10199.1 - 0.017 14.5 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF3584 PF12128.3 ESL10199.1 - 0.021 12.1 0.1 0.03 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NACHT PF05729.7 ESL10199.1 - 0.024 14.2 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 0 NACHT domain RuvB_N PF05496.7 ESL10199.1 - 0.098 11.6 0.3 26 3.7 0.0 3.3 4 0 0 4 4 4 0 Holliday junction DNA helicase ruvB N-terminus SH3_9 PF14604.1 ESL10200.1 - 2e-08 33.6 0.0 3.4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESL10200.1 - 8.7e-08 31.5 0.3 1.6e-07 30.7 0.1 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 ESL10200.1 - 7.9e-06 25.1 0.0 1.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Filament PF00038.16 ESL10200.1 - 0.00015 21.3 4.3 0.00024 20.6 3.0 1.2 1 0 0 1 1 1 1 Intermediate filament protein Tmemb_cc2 PF10267.4 ESL10200.1 - 0.0021 16.7 0.3 0.0027 16.3 0.2 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Med9 PF07544.8 ESL10200.1 - 0.018 14.7 1.2 0.04 13.6 0.8 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF1319 PF07028.6 ESL10200.1 - 0.055 13.6 0.9 0.084 13.0 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) DUF4201 PF13870.1 ESL10200.1 - 0.14 11.5 5.3 0.23 10.8 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) COG2 PF06148.6 ESL10200.1 - 0.18 11.7 1.3 0.38 10.6 0.9 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 GBP_C PF02841.9 ESL10200.1 - 0.28 10.3 5.0 0.51 9.4 3.5 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DivIC PF04977.10 ESL10200.1 - 0.42 10.1 2.7 0.85 9.1 1.9 1.6 1 0 0 1 1 1 0 Septum formation initiator Atg14 PF10186.4 ESL10200.1 - 0.49 9.2 4.2 0.71 8.7 2.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF972 PF06156.8 ESL10200.1 - 3.6 7.9 5.1 0.93 9.8 1.4 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF972) DUF2746 PF10874.3 ESL10201.1 - 0.014 15.5 3.4 0.026 14.6 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) FlxA PF14282.1 ESL10201.1 - 0.053 13.4 0.9 0.053 13.4 0.6 2.2 2 1 0 2 2 2 0 FlxA-like protein Tropomyosin PF00261.15 ESL10201.1 - 0.095 11.7 20.0 0.25 10.4 13.8 1.6 1 1 0 1 1 1 0 Tropomyosin Phage_lysis PF03245.8 ESL10201.1 - 0.88 9.5 14.3 0.56 10.2 7.2 2.1 2 1 0 2 2 2 0 Bacteriophage Rz lysis protein CENP-F_leu_zip PF10473.4 ESL10201.1 - 1.4 8.8 16.2 0.16 11.8 6.6 2.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V-SNARE PF05008.10 ESL10201.1 - 1.9 8.6 10.0 0.33 11.1 3.4 2.4 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF812 PF05667.6 ESL10201.1 - 2.2 6.7 12.1 2.3 6.6 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Striatin PF08232.7 ESL10201.1 - 2.3 8.5 10.9 11 6.3 4.3 2.2 1 1 1 2 2 2 0 Striatin family LRS4 PF10422.4 ESL10201.1 - 4.1 6.6 7.1 4.4 6.5 4.9 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 PEPCK_ATP PF01293.15 ESL10202.1 - 4.4e-47 160.6 0.0 5.6e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF383 PF04063.9 ESL10203.1 - 1.2e-07 31.4 0.0 2.8e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF383) Mitovir_RNA_pol PF05919.6 ESL10203.1 - 0.018 14.0 0.1 0.033 13.1 0.0 1.4 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase HEAT PF02985.17 ESL10203.1 - 0.052 13.6 0.1 11 6.3 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat Pkinase PF00069.20 ESL10205.1 - 7.1e-40 136.8 0.0 1.3e-39 135.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10205.1 - 8.6e-17 61.0 0.0 2.9e-15 56.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10205.1 - 7.7e-07 28.3 0.2 0.0035 16.3 0.0 2.9 3 0 0 3 3 3 2 Kinase-like Seadorna_VP7 PF07387.6 ESL10205.1 - 0.008 15.0 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 ESL10205.1 - 0.083 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.17 ESL10206.1 - 9.8e-13 47.5 0.0 1.5e-08 34.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL10206.1 - 6.2e-10 38.7 0.0 2.3e-09 36.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL10206.1 - 7e-10 38.7 0.0 3.2e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) EF_assoc_1 PF08355.7 ESL10206.1 - 0.081 12.2 0.0 0.33 10.2 0.0 2.0 1 1 0 1 1 1 0 EF hand associated Ribosomal_L30 PF00327.15 ESL10207.1 - 4.1e-18 64.7 1.0 1e-17 63.4 0.7 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 ESL10207.1 - 9.1e-17 60.8 12.4 1.7e-16 60.0 8.6 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Mito_carr PF00153.22 ESL10208.1 - 1.4e-59 197.7 0.3 8.7e-22 76.6 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1218 PF06749.7 ESL10209.1 - 0.021 15.2 0.7 0.039 14.4 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) NADH_4Fe-4S PF10589.4 ESL10209.1 - 0.065 12.4 0.2 0.14 11.3 0.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region DUF2754 PF10953.3 ESL10209.1 - 0.12 12.4 0.4 0.12 12.4 0.3 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF2754) SQS_PSY PF00494.14 ESL10210.1 - 8.6e-43 146.5 0.1 1.4e-42 145.8 0.0 1.4 1 0 0 1 1 1 1 Squalene/phytoene synthase GATase PF00117.23 ESL10211.1 - 6.4e-36 123.6 0.0 1e-35 122.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 ESL10211.1 - 1.8e-26 91.6 0.1 2.6e-25 87.9 0.1 2.7 1 1 0 1 1 1 1 GMP synthase C terminal domain Peptidase_C26 PF07722.8 ESL10211.1 - 6.9e-15 55.0 0.1 6e-14 52.0 0.0 2.6 1 1 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.12 ESL10211.1 - 3.4e-07 29.4 0.0 6.6e-05 21.9 0.0 2.2 2 0 0 2 2 2 2 NAD synthase QueC PF06508.8 ESL10211.1 - 1.3e-05 24.6 0.0 0.00012 21.4 0.0 2.4 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 ESL10211.1 - 0.00067 19.1 0.0 0.0032 16.9 0.0 2.0 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.15 ESL10211.1 - 0.0024 17.3 0.0 0.0075 15.7 0.0 1.8 2 0 0 2 2 2 1 PP-loop family Asn_synthase PF00733.16 ESL10211.1 - 0.0055 16.2 0.0 0.0094 15.4 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase Arginosuc_synth PF00764.14 ESL10211.1 - 0.0083 15.2 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase tRNA_Me_trans PF03054.11 ESL10211.1 - 0.016 13.7 0.0 0.036 12.6 0.1 1.5 2 0 0 2 2 2 0 tRNA methyl transferase Dus PF01207.12 ESL10212.1 - 5.6e-55 186.3 0.3 7.5e-55 185.9 0.2 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) NMO PF03060.10 ESL10212.1 - 0.00019 20.7 0.1 0.00028 20.1 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase TMP-TENI PF02581.12 ESL10212.1 - 0.0027 16.8 0.2 0.0055 15.8 0.1 1.5 1 1 0 1 1 1 1 Thiamine monophosphate synthase/TENI His_biosynth PF00977.16 ESL10212.1 - 0.0036 16.6 0.0 0.0063 15.8 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 ESL10212.1 - 0.0052 15.8 0.2 0.0089 15.1 0.1 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG F_bP_aldolase PF01116.15 ESL10212.1 - 0.033 13.2 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II DHO_dh PF01180.16 ESL10212.1 - 0.072 12.0 0.0 0.38 9.6 0.0 1.9 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase WD40 PF00400.27 ESL10213.1 - 2.8e-41 137.9 13.1 2.6e-08 33.4 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat PQQ_3 PF13570.1 ESL10213.1 - 0.008 16.4 0.3 2.9 8.3 0.0 3.5 3 0 0 3 3 3 1 PQQ-like domain DUF3312 PF11768.3 ESL10213.1 - 0.027 12.7 0.2 6.1 4.9 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3312) PQQ_2 PF13360.1 ESL10213.1 - 0.082 12.3 0.0 0.28 10.6 0.0 1.7 1 1 0 1 1 1 0 PQQ-like domain Elf-1_N PF12310.3 ESL10214.1 - 0.044 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcription factor protein N terminal Ribosomal_L3 PF00297.17 ESL10215.1 - 1.1e-100 336.3 9.5 1.4e-100 336.0 6.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Pkinase PF00069.20 ESL10216.1 - 4.3e-62 209.6 0.0 6.1e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10216.1 - 1.4e-31 109.4 0.0 2.3e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Lipocalin_5 PF13924.1 ESL10216.1 - 1.5e-30 105.6 0.0 2.9e-30 104.7 0.0 1.5 1 0 0 1 1 1 1 Lipocalin-like domain PX PF00787.19 ESL10216.1 - 2.9e-11 43.1 0.1 5.4e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.1 ESL10216.1 - 1.5e-08 33.9 0.0 2.4e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FYVE PF01363.16 ESL10216.1 - 5.1e-05 23.0 9.8 0.00013 21.7 6.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESL10216.1 - 0.0066 16.2 0.1 0.13 11.9 0.2 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family FYVE_2 PF02318.11 ESL10216.1 - 0.12 12.2 7.0 0.29 11.0 4.8 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger GCV_H PF01597.14 ESL10218.1 - 2.3e-38 130.5 0.1 2.7e-38 130.3 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 ESL10218.1 - 6.2e-05 22.5 0.1 0.00012 21.6 0.1 1.5 1 1 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.1 ESL10218.1 - 0.00021 20.9 0.2 0.0003 20.4 0.1 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Motile_Sperm PF00635.21 ESL10219.1 - 1.7e-14 53.3 0.3 4.1e-14 52.1 0.0 1.7 2 0 0 2 2 2 1 MSP (Major sperm protein) domain AAA_5 PF07728.9 ESL10221.1 - 9.5e-07 28.6 0.0 2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESL10221.1 - 2.7e-06 27.4 0.0 6.5e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL10221.1 - 2.5e-05 24.4 0.0 0.00062 19.9 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESL10221.1 - 0.001 19.1 0.5 0.024 14.6 0.0 3.2 4 1 0 4 4 4 1 AAA ATPase domain AAA PF00004.24 ESL10221.1 - 0.0014 18.8 0.0 0.0041 17.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Baculo_RING PF05883.6 ESL10221.1 - 0.0036 17.1 0.2 0.0067 16.2 0.2 1.4 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain AAA_17 PF13207.1 ESL10221.1 - 0.014 16.2 0.0 0.04 14.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.7 ESL10221.1 - 0.022 13.8 0.0 0.072 12.1 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus NACHT PF05729.7 ESL10221.1 - 0.025 14.2 0.0 0.12 12.0 0.0 2.1 1 1 0 1 1 1 0 NACHT domain Papilloma_E5A PF05776.7 ESL10221.1 - 0.32 11.1 10.6 0.72 10.0 7.4 1.5 1 0 0 1 1 1 0 Papillomavirus E5A protein Histone PF00125.19 ESL10222.1 - 8.3e-18 64.2 0.6 1.1e-17 63.8 0.4 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL10222.1 - 0.00019 21.3 0.2 0.00039 20.4 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ClpB_D2-small PF10431.4 ESL10222.1 - 0.066 13.1 0.1 0.72 9.7 0.1 2.1 1 1 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein Baculo_11_kDa PF06143.6 ESL10223.1 - 0.046 13.0 0.0 0.046 13.0 0.0 2.4 3 0 0 3 3 3 0 Baculovirus 11 kDa family EF1G PF00647.14 ESL10224.1 - 1.8e-18 66.2 0.2 2.3e-18 65.8 0.1 1.2 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain IncA PF04156.9 ESL10225.1 - 0.0062 16.1 4.9 0.0062 16.1 3.4 4.9 1 1 3 4 4 4 1 IncA protein DUF3867 PF12983.2 ESL10225.1 - 3.4 7.6 8.9 2.2 8.2 1.4 3.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3867) PDZ_2 PF13180.1 ESL10226.1 - 1.5e-10 40.7 0.0 5.6e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 ESL10226.1 - 0.00021 21.4 0.0 0.00044 20.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PI-PLC-X PF00388.14 ESL10226.1 - 0.046 13.1 0.0 0.13 11.6 0.0 1.8 1 1 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.6 ESL10226.1 - 0.049 13.6 0.3 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like VCBS PF13517.1 ESL10227.1 - 2.8e-13 50.0 11.4 0.00036 20.8 1.5 5.6 4 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 ESL10227.1 - 5.4e-11 41.8 22.6 0.074 12.7 0.1 5.9 5 0 0 5 5 5 5 FG-GAP repeat PQQ_2 PF13360.1 ESL10227.1 - 2.8e-06 26.9 2.1 0.052 13.0 0.1 3.2 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.1 ESL10227.1 - 1.8e-05 24.8 8.2 0.92 9.8 0.6 5.3 5 0 0 5 5 5 3 PQQ-like domain TcdB_toxin_midN PF12256.3 ESL10227.1 - 0.0079 15.6 6.3 2.9 7.2 0.0 4.7 4 1 1 5 5 5 2 Insecticide toxin TcdB middle/N-terminal region Flagellar_rod PF05149.7 ESL10228.1 - 8.3e-112 373.0 26.7 1.2e-111 372.6 18.5 1.2 1 0 0 1 1 1 1 Paraflagellar rod protein SpoIISA_toxin PF14171.1 ESL10228.1 - 0.36 10.0 4.6 0.092 11.9 0.7 1.8 2 0 0 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system DUF2937 PF11157.3 ESL10228.1 - 2.7 7.2 7.1 1 8.6 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF3492 PF11997.3 ESL10228.1 - 2.9 7.3 10.0 0.53 9.7 1.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3492) UCH PF00443.24 ESL10230.1 - 6.2e-50 169.8 0.0 1.5e-49 168.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL10230.1 - 1.3e-20 74.0 0.1 8.5e-10 38.5 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 ESL10230.1 - 0.06 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 DUSP domain FAM91_C PF14648.1 ESL10231.1 - 1.5e-139 465.7 0.1 2.2e-139 465.1 0.0 1.2 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.1 ESL10231.1 - 3.4e-104 348.2 0.0 5.3e-104 347.5 0.0 1.3 1 0 0 1 1 1 1 FAM91 N-terminus HAUS-augmin3 PF14932.1 ESL10231.1 - 0.19 10.8 0.0 0.36 9.9 0.0 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 RCC1 PF00415.13 ESL10232.1 - 3.6e-27 94.3 1.7 5.8e-09 36.0 0.0 4.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL10232.1 - 2.3e-16 58.8 8.9 3e-09 36.2 0.4 4.5 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Frizzled PF01534.12 ESL10233.1 - 0.043 12.6 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region ABC2_membrane_5 PF13346.1 ESL10235.1 - 0.74 9.0 15.1 0.11 11.7 7.9 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2101 PF09874.4 ESL10235.1 - 2 7.8 14.0 1 8.7 7.7 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) MARVEL PF01284.18 ESL10235.1 - 7.2 6.4 14.6 11 5.8 10.1 1.5 1 1 0 1 1 1 0 Membrane-associating domain 4HBT PF03061.17 ESL10236.1 - 2.5e-13 49.9 3.3 5.1e-08 32.9 0.6 2.7 2 0 0 2 2 2 2 Thioesterase superfamily 4HBT_2 PF13279.1 ESL10236.1 - 8.4e-05 23.0 0.5 0.0044 17.4 0.3 2.3 1 1 0 2 2 2 1 Thioesterase-like superfamily MaoC_dehydratas PF01575.14 ESL10236.1 - 0.064 12.6 0.4 3.5 7.0 0.1 2.5 2 0 0 2 2 2 0 MaoC like domain DIM1 PF02966.11 ESL10237.1 - 2.1e-32 111.4 0.0 3.3e-26 91.3 0.0 2.0 2 0 0 2 2 2 2 Mitosis protein DIM1 TK PF00265.13 ESL10238.1 - 1.6e-58 197.1 0.1 1.9e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 Thymidine kinase Cytochrome_C7 PF14522.1 ESL10238.1 - 0.0037 16.8 1.4 0.012 15.1 0.3 2.3 2 1 0 2 2 2 1 Cytochrome c7 AAA_14 PF13173.1 ESL10238.1 - 0.013 15.4 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytochrom_c3_2 PF14537.1 ESL10238.1 - 3.1 8.1 7.7 2.3 8.5 3.0 2.3 2 1 0 2 2 2 0 Cytochrome c3 zf-UBP PF02148.14 ESL10239.1 - 9.3e-19 67.3 3.6 3.5e-18 65.4 2.5 2.0 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Thioredoxin PF00085.15 ESL10240.1 - 1.3e-26 92.3 0.0 8.6e-25 86.4 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL10240.1 - 3.7e-11 43.1 0.1 5.3e-08 33.0 0.0 2.9 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESL10240.1 - 9.7e-09 35.2 0.0 8.6e-06 25.7 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_6 PF13848.1 ESL10240.1 - 0.00019 21.2 0.0 0.41 10.4 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain Redoxin PF08534.5 ESL10240.1 - 0.00078 19.0 0.0 0.0025 17.3 0.0 1.8 2 0 0 2 2 2 1 Redoxin Thioredoxin_7 PF13899.1 ESL10240.1 - 0.0018 18.2 0.0 0.0046 16.9 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESL10240.1 - 0.0034 16.9 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.6 ESL10240.1 - 0.0069 16.2 0.0 5.4 6.9 0.0 2.7 2 1 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.1 ESL10240.1 - 0.18 11.3 0.0 9.4 5.7 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin adh_short PF00106.20 ESL10244.1 - 2.7e-20 72.9 0.7 2.7e-20 72.9 0.5 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ESL10244.1 - 1.5e-09 37.7 0.3 2.5e-09 37.0 0.2 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESL10244.1 - 1e-05 25.1 0.1 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESL10244.1 - 3.1e-05 24.0 0.1 6.2e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_7 PF13241.1 ESL10244.1 - 0.0095 16.1 0.1 0.025 14.8 0.0 1.7 2 0 0 2 2 2 1 Putative NAD(P)-binding adh_short_C2 PF13561.1 ESL10244.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Nol1_Nop2_Fmu PF01189.12 ESL10244.1 - 0.036 13.4 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 NOL1/NOP2/sun family 3HCDH_N PF02737.13 ESL10244.1 - 0.036 13.7 0.3 0.056 13.0 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.20 ESL10245.1 - 1.2e-56 191.7 0.1 8.4e-56 188.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10245.1 - 4.7e-34 117.6 0.2 1.2e-23 83.5 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESL10245.1 - 7.9e-06 25.7 0.1 0.0073 16.0 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL10245.1 - 0.001 18.1 0.1 0.0025 16.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pox_ser-thr_kin PF05445.6 ESL10245.1 - 0.032 13.0 0.0 0.054 12.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 ESL10245.1 - 0.052 12.6 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M14 PF00246.19 ESL10246.1 - 6.5e-17 62.0 0.0 1.1e-16 61.3 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESL10246.1 - 0.0053 15.6 0.0 0.0075 15.1 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF1510 PF07423.6 ESL10246.1 - 1.4 8.2 11.1 2.8 7.2 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Daxx PF03344.10 ESL10246.1 - 8.1 4.7 24.3 4.5 5.6 14.9 1.8 2 0 0 2 2 2 0 Daxx Family DUF641 PF04859.7 ESL10247.1 - 0.004 16.8 4.2 0.004 16.8 2.9 1.8 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Laminin_II PF06009.7 ESL10247.1 - 0.014 15.1 2.6 0.034 13.8 1.8 1.6 1 0 0 1 1 1 0 Laminin Domain II TPR_MLP1_2 PF07926.7 ESL10247.1 - 0.027 14.2 8.7 0.08 12.6 6.1 1.7 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.6 ESL10247.1 - 0.061 11.9 6.2 0.12 11.0 4.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Phage_GP20 PF06810.6 ESL10247.1 - 3.6 7.0 13.0 0.15 11.5 4.4 1.9 2 0 0 2 2 2 0 Phage minor structural protein GP20 FYVE_2 PF02318.11 ESL10249.1 - 0.02 14.7 3.1 0.03 14.2 2.1 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger DZR PF12773.2 ESL10249.1 - 0.11 12.3 3.7 4.8 7.0 2.6 2.5 1 1 0 1 1 1 0 Double zinc ribbon DUF3133 PF11331.3 ESL10249.1 - 0.15 11.6 0.6 0.15 11.6 0.4 2.4 2 1 0 3 3 3 0 Protein of unknown function (DUF3133) DUF4428 PF14471.1 ESL10249.1 - 0.15 11.8 2.8 0.33 10.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) zf-CHY PF05495.7 ESL10249.1 - 0.15 12.1 3.5 1.9 8.6 0.2 2.3 1 1 1 2 2 2 0 CHY zinc finger zf-piccolo PF05715.8 ESL10249.1 - 0.23 11.5 3.9 0.45 10.5 2.7 1.6 1 1 0 1 1 1 0 Piccolo Zn-finger RNHCP PF12647.2 ESL10249.1 - 0.37 10.6 6.1 0.21 11.4 1.7 2.1 1 1 1 2 2 2 0 RNHCP domain C1_1 PF00130.17 ESL10249.1 - 7.4 6.3 8.6 3.4 7.4 1.9 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) MMR_HSR1 PF01926.18 ESL10250.1 - 2.3e-08 34.0 0.0 4e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL10250.1 - 0.00019 20.7 0.0 0.00043 19.5 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESL10250.1 - 0.011 15.1 0.0 0.26 10.6 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL10250.1 - 0.15 12.5 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Rad4 PF03835.10 ESL10251.1 - 1.7e-19 69.6 0.1 1.7e-19 69.6 0.1 2.0 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 ESL10251.1 - 1.9e-19 69.1 0.0 3.9e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 ESL10251.1 - 3.6e-14 52.0 0.0 7.6e-14 50.9 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 ESL10251.1 - 5.7e-09 36.1 0.0 2.6e-08 34.0 0.0 2.3 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 DUF3735 PF12537.3 ESL10251.1 - 0.21 11.6 0.5 0.64 10.1 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3735) Bromodomain PF00439.20 ESL10252.1 - 0.15 11.9 0.0 0.47 10.4 0.0 1.8 1 1 0 1 1 1 0 Bromodomain HD PF01966.17 ESL10253.1 - 1.1e-13 51.2 0.1 3.4e-13 49.6 0.0 1.9 2 0 0 2 2 2 1 HD domain HDOD PF08668.7 ESL10253.1 - 0.038 13.2 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 HDOD domain FKBP_C PF00254.23 ESL10256.1 - 2.8e-09 36.8 0.0 9.7e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase zf-DHHC PF01529.15 ESL10257.1 - 9.1e-24 83.7 5.1 9.1e-24 83.7 3.5 1.7 1 1 1 2 2 2 1 DHHC palmitoyltransferase Claudin_2 PF13903.1 ESL10257.1 - 0.097 12.3 9.9 1.2 8.8 1.1 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF1628 PF07790.6 ESL10257.1 - 9.4 7.0 10.7 2.3 9.0 0.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1628) Xan_ur_permease PF00860.15 ESL10258.1 - 0.023 13.1 0.6 0.042 12.3 0.1 1.6 1 1 1 2 2 2 0 Permease family RCC1 PF00415.13 ESL10259.1 - 8.1e-60 198.8 50.9 3e-14 52.9 0.3 12.7 12 1 0 12 12 12 10 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL10259.1 - 9.8e-48 158.8 76.0 2.1e-09 36.7 0.6 14.3 14 0 0 14 14 14 10 Regulator of chromosome condensation (RCC1) repeat Adenylsucc_synt PF00709.16 ESL10259.1 - 0.045 12.4 0.0 0.071 11.7 0.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate synthetase DUF543 PF04418.7 ESL10259.1 - 8.6 6.3 8.4 4 7.4 0.3 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF543) SelR PF01641.13 ESL10260.1 - 0.017 14.7 0.8 0.017 14.7 0.5 1.9 2 1 1 3 3 3 0 SelR domain MRVI1 PF05781.7 ESL10262.1 - 0.085 11.2 0.1 0.1 10.9 0.1 1.0 1 0 0 1 1 1 0 MRVI1 protein LRR_6 PF13516.1 ESL10263.1 - 0.0033 17.3 3.5 3.5 7.9 0.0 5.0 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.28 ESL10263.1 - 0.33 11.1 2.9 23 5.5 0.0 4.4 4 1 1 5 5 5 0 Leucine Rich Repeat OmpH PF03938.9 ESL10263.1 - 3.8 7.4 4.8 6.3 6.7 3.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4131 PF13567.1 ESL10263.1 - 7.2 5.9 6.8 13 5.1 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SRP54 PF00448.17 ESL10264.1 - 2.9e-56 190.0 0.1 6e-56 188.9 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.8 ESL10264.1 - 5.8e-09 35.7 3.4 7.5e-08 32.0 2.4 2.1 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal AAA_22 PF13401.1 ESL10264.1 - 8.7e-07 29.1 0.0 3.9e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL10264.1 - 2.5e-06 26.7 0.0 2.5e-06 26.7 0.0 2.7 3 0 0 3 3 2 1 Zeta toxin AAA_30 PF13604.1 ESL10264.1 - 4.5e-05 23.1 0.3 4.5e-05 23.1 0.2 2.1 3 0 0 3 3 2 1 AAA domain ETF PF01012.16 ESL10264.1 - 0.0001 22.0 1.4 0.15 11.7 0.1 2.8 2 0 0 2 2 2 2 Electron transfer flavoprotein domain CbiA PF01656.18 ESL10264.1 - 0.00013 21.4 0.0 0.0011 18.4 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.10 ESL10264.1 - 0.00084 19.0 0.0 0.51 10.0 0.0 2.5 2 0 0 2 2 2 1 NTPase cobW PF02492.14 ESL10264.1 - 0.0013 18.2 0.1 0.0038 16.6 0.1 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 ESL10264.1 - 0.0014 18.5 0.9 0.025 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESL10264.1 - 0.0018 17.9 4.2 0.039 13.7 0.0 3.5 2 1 1 3 3 3 1 Part of AAA domain ArgK PF03308.11 ESL10264.1 - 0.0019 17.0 0.1 0.0068 15.2 0.1 2.0 1 1 0 1 1 1 1 ArgK protein APS_kinase PF01583.15 ESL10264.1 - 0.0028 17.3 0.0 0.0061 16.2 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase DAP3 PF10236.4 ESL10264.1 - 0.0038 16.2 0.0 0.0064 15.4 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 MobB PF03205.9 ESL10264.1 - 0.0043 16.7 0.1 0.08 12.6 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ArsA_ATPase PF02374.10 ESL10264.1 - 0.0045 16.0 0.2 0.084 11.8 0.0 2.4 3 0 0 3 3 2 1 Anion-transporting ATPase AAA_10 PF12846.2 ESL10264.1 - 0.0046 16.4 0.1 0.012 15.0 0.1 1.8 1 1 0 1 1 1 1 AAA-like domain AAA_24 PF13479.1 ESL10264.1 - 0.0049 16.4 0.0 0.019 14.5 0.0 2.0 2 1 0 2 2 1 1 AAA domain SRP54_N PF02881.14 ESL10264.1 - 0.0069 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_16 PF13191.1 ESL10264.1 - 0.017 15.1 2.7 0.023 14.6 0.0 2.6 2 2 1 3 3 3 0 AAA ATPase domain MMR_HSR1 PF01926.18 ESL10264.1 - 0.021 14.7 0.0 0.048 13.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.12 ESL10264.1 - 0.025 13.9 0.0 0.082 12.2 0.0 1.9 1 0 0 1 1 1 0 Thymidylate kinase ABC_tran PF00005.22 ESL10264.1 - 0.041 14.1 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA PF00004.24 ESL10264.1 - 0.043 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ESL10264.1 - 0.047 13.3 0.0 0.59 9.7 0.0 2.3 2 0 0 2 2 2 0 NACHT domain DUF258 PF03193.11 ESL10264.1 - 0.068 12.3 0.0 0.39 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF2075 PF09848.4 ESL10264.1 - 0.11 11.4 0.0 0.25 10.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 ESL10264.1 - 0.13 11.8 0.0 0.33 10.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 ESL10264.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 ESL10264.1 - 0.36 9.4 0.0 0.36 9.4 0.0 1.5 2 0 0 2 2 1 0 G-protein alpha subunit Aminotran_1_2 PF00155.16 ESL10265.1 - 1.2e-50 172.4 0.0 1.3e-50 172.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 ESL10265.1 - 0.13 11.4 0.0 0.27 10.3 0.0 1.5 2 0 0 2 2 2 0 Beta-eliminating lyase Thioredoxin PF00085.15 ESL10266.1 - 2.7e-31 107.3 0.0 1.1e-28 98.9 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.1 ESL10266.1 - 1.3e-12 47.9 0.0 7.2e-07 29.1 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESL10266.1 - 2.7e-07 30.5 0.0 4.5e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 ESL10266.1 - 4.8e-07 29.9 0.0 1.4e-05 25.2 0.0 2.6 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 ESL10266.1 - 4.1e-05 23.1 0.0 0.00011 21.7 0.0 1.7 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.16 ESL10266.1 - 0.0003 20.4 0.0 0.00068 19.3 0.0 1.7 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.1 ESL10266.1 - 0.0011 19.1 0.0 0.0052 16.8 0.0 2.1 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESL10266.1 - 0.0084 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Big_3 PF07523.7 ESL10266.1 - 0.1 12.6 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) DUF3451 PF11933.3 ESL10267.1 - 0.00029 20.7 7.7 0.00029 20.7 5.3 2.4 4 0 0 4 4 4 1 Domain of unknown function (DUF3451) DUF3250 PF11618.3 ESL10267.1 - 0.00097 19.3 0.3 0.01 16.0 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3250) DUF972 PF06156.8 ESL10267.1 - 0.78 10.1 40.9 0.3 11.4 0.3 6.4 3 1 3 6 6 6 0 Protein of unknown function (DUF972) Spc7 PF08317.6 ESL10267.1 - 8 5.0 49.7 0.12 10.9 10.6 5.0 3 1 2 5 5 5 0 Spc7 kinetochore protein CTDII PF01556.13 ESL10268.1 - 1.1e-22 79.6 0.2 8.5e-17 60.8 0.0 2.4 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 ESL10268.1 - 3.8e-22 77.7 0.5 6.9e-22 76.9 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESL10268.1 - 3.4e-14 52.6 19.5 3.4e-14 52.6 13.5 1.7 2 0 0 2 2 2 1 DnaJ central domain Cytochrom_c3_2 PF14537.1 ESL10268.1 - 0.048 13.9 11.7 0.15 12.4 8.1 1.9 1 0 0 1 1 1 0 Cytochrome c3 HypA PF01155.14 ESL10268.1 - 0.12 12.0 7.9 0.5 10.0 0.5 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family ATP-grasp_2 PF08442.5 ESL10269.1 - 9.4e-63 211.2 0.9 1.7e-62 210.4 0.6 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 ESL10269.1 - 4.1e-24 84.9 0.4 1e-23 83.6 0.1 1.8 2 0 0 2 2 2 1 CoA-ligase GARS_A PF01071.14 ESL10269.1 - 0.0036 16.8 0.6 0.013 15.1 0.4 1.9 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PIF1 PF05970.9 ESL10270.1 - 6.5e-47 160.2 0.0 7e-37 127.2 0.0 3.1 3 0 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 ESL10270.1 - 1.5e-16 60.5 0.0 4.4e-16 59.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL10270.1 - 1.7e-08 34.6 0.0 3.6e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.9 ESL10270.1 - 2.9e-08 31.9 0.1 0.00035 18.4 0.0 2.1 2 0 0 2 2 2 2 Helicase AAA_19 PF13245.1 ESL10270.1 - 4.8e-08 32.6 0.6 1.5e-07 31.0 0.4 1.9 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 ESL10270.1 - 2.1e-06 27.4 0.9 0.041 13.3 0.1 3.4 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.1 ESL10270.1 - 4.2e-05 23.2 0.6 0.004 16.7 0.0 3.0 2 1 1 3 3 3 1 AAA domain DUF2075 PF09848.4 ESL10270.1 - 0.00013 21.0 0.1 0.00078 18.5 0.1 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 ESL10270.1 - 0.00022 21.2 0.1 0.00081 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain TrwB_AAD_bind PF10412.4 ESL10270.1 - 0.00025 19.7 0.1 0.00046 18.9 0.1 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain UvrD_C_2 PF13538.1 ESL10270.1 - 0.00054 20.0 0.1 0.0017 18.4 0.1 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.9 ESL10270.1 - 0.00097 18.8 0.1 0.0035 17.0 0.1 1.9 1 1 0 1 1 1 1 Helicase IstB_IS21 PF01695.12 ESL10270.1 - 0.0092 15.4 0.0 0.033 13.6 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein KaiC PF06745.8 ESL10270.1 - 0.014 14.5 0.1 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 KaiC MobB PF03205.9 ESL10270.1 - 0.018 14.7 0.7 0.037 13.7 0.1 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 ESL10270.1 - 0.02 13.7 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD-helicase PF00580.16 ESL10270.1 - 0.027 13.7 1.2 0.027 13.7 0.1 1.5 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Arch_ATPase PF01637.13 ESL10270.1 - 0.027 14.1 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_5 PF07728.9 ESL10270.1 - 0.03 14.0 0.0 0.071 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 ESL10270.1 - 0.031 14.4 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Torsin PF06309.6 ESL10270.1 - 0.055 13.3 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Torsin Sigma54_activat PF00158.21 ESL10270.1 - 0.071 12.5 0.1 0.24 10.8 0.1 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.11 ESL10270.1 - 0.073 12.2 0.1 0.17 11.0 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein Bim_N PF06773.6 ESL10270.1 - 0.073 12.8 5.4 5.4 6.8 0.0 2.8 2 0 0 2 2 2 0 Bim protein N-terminus DEAD PF00270.24 ESL10270.1 - 0.11 11.9 0.0 1.3 8.4 0.0 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase Prefoldin_2 PF01920.15 ESL10271.1 - 3.9e-12 45.8 2.2 7.1e-12 45.0 1.5 1.5 1 1 0 1 1 1 1 Prefoldin subunit OmpH PF03938.9 ESL10271.1 - 0.32 10.9 9.0 0.49 10.3 6.3 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Med30 PF11315.3 ESL10271.1 - 0.76 9.8 6.0 0.18 11.9 1.2 1.8 1 1 1 2 2 2 0 Mediator complex subunit 30 PEP-utilisers_N PF05524.8 ESL10271.1 - 1.3 8.8 8.3 0.63 9.8 1.4 2.1 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF4164 PF13747.1 ESL10271.1 - 3.3 7.9 11.6 2.6 8.2 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DivIC PF04977.10 ESL10271.1 - 8.1 6.0 7.0 28 4.2 1.6 2.4 2 1 0 2 2 2 0 Septum formation initiator Sec1 PF00995.18 ESL10272.1 - 1.3e-32 113.2 0.0 1.4e-32 113.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family E1-E2_ATPase PF00122.15 ESL10273.1 - 1.5e-58 197.5 5.1 5.6e-58 195.6 4.0 1.6 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESL10273.1 - 3.7e-24 86.3 0.0 1.7e-23 84.1 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESL10273.1 - 1.4e-13 50.1 0.0 3.2e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 ESL10273.1 - 2.6e-13 50.6 0.1 9.3e-13 48.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL10273.1 - 0.00012 21.7 0.1 0.00069 19.2 0.0 2.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL10273.1 - 0.031 14.2 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit DUF1936 PF09151.5 ESL10274.1 - 0.082 12.4 0.7 0.19 11.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) GSP_synth PF03738.9 ESL10275.1 - 5.9e-28 96.9 0.2 1.4e-27 95.7 0.1 1.7 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CHAP PF05257.11 ESL10275.1 - 2.8e-20 72.2 0.0 5.7e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 CHAP domain CutA1 PF03091.10 ESL10276.1 - 2.1e-34 117.2 0.1 2.3e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Ribosomal_S8e PF01201.17 ESL10277.1 - 1.3e-35 122.4 10.9 2.2e-34 118.4 7.6 2.1 1 1 0 1 1 1 1 Ribosomal protein S8e Tox-SHH PF15652.1 ESL10277.1 - 7.5 7.2 6.6 2.2 8.9 0.4 2.3 1 1 1 2 2 2 0 HNH/Endo VII superfamily toxin with a SHH signature EnY2 PF10163.4 ESL10278.1 - 4.8e-06 26.3 0.0 6.2e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 FAM53 PF15242.1 ESL10278.1 - 0.083 12.4 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Family of FAM53 DNA_pol_A PF00476.15 ESL10280.1 - 9.7e-30 103.4 0.0 1.8e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A Atg14 PF10186.4 ESL10281.1 - 0.33 9.8 12.4 0.38 9.6 2.8 2.8 3 0 0 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 COPIIcoated_ERV PF07970.7 ESL10282.1 - 6.6e-67 225.3 0.0 9.5e-67 224.8 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 ESL10282.1 - 2.2e-26 91.6 0.0 4.8e-26 90.5 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) QueC PF06508.8 ESL10282.1 - 0.12 11.6 0.2 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC AAA_2 PF07724.9 ESL10284.1 - 2.7e-38 131.5 3.6 2.6e-30 105.5 1.1 2.6 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESL10284.1 - 3.1e-12 46.8 1.6 5.8e-05 23.2 0.1 2.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 ESL10284.1 - 3.9e-08 33.0 0.7 1.4e-07 31.3 0.5 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 ESL10284.1 - 7.6e-07 28.9 0.4 3.1e-05 23.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) MCM PF00493.18 ESL10284.1 - 2.8e-06 26.3 0.3 0.00038 19.3 0.0 2.4 2 0 0 2 2 2 1 MCM2/3/5 family AAA_22 PF13401.1 ESL10284.1 - 1.9e-05 24.7 0.0 0.0042 17.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESL10284.1 - 3.3e-05 24.6 1.2 0.00026 21.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESL10284.1 - 0.00039 20.7 1.0 0.0033 17.7 0.0 2.7 2 1 1 3 3 3 1 AAA domain Zeta_toxin PF06414.7 ESL10284.1 - 0.00043 19.4 0.2 0.0011 18.1 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 ESL10284.1 - 0.0018 18.3 0.1 0.053 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.21 ESL10284.1 - 0.0019 17.7 0.1 0.085 12.3 0.0 3.1 3 1 1 4 4 3 1 Sigma-54 interaction domain AAA_14 PF13173.1 ESL10284.1 - 0.0048 16.7 0.1 3.1 7.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESL10284.1 - 0.017 14.1 0.4 0.74 8.8 0.0 2.6 2 1 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 ESL10284.1 - 0.019 14.8 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 ESL10284.1 - 0.026 13.6 0.0 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 ESL10284.1 - 0.038 13.4 0.0 0.1 12.0 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein CPT PF07931.7 ESL10284.1 - 0.046 13.3 0.0 0.34 10.5 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ATP-synt_ab PF00006.20 ESL10284.1 - 0.058 12.8 0.0 0.13 11.6 0.0 1.6 2 0 0 2 2 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ResIII PF04851.10 ESL10284.1 - 0.066 13.0 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit AAA_3 PF07726.6 ESL10284.1 - 0.074 12.6 0.1 2.2 7.8 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) IPT PF01745.11 ESL10284.1 - 0.078 12.1 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 Isopentenyl transferase RNA_helicase PF00910.17 ESL10284.1 - 0.091 12.9 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Abhydrolase_6 PF12697.2 ESL10285.1 - 1.9e-16 60.6 0.0 2.9e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL10285.1 - 2.3e-11 43.6 0.0 5e-11 42.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL10285.1 - 3.8e-06 26.6 0.0 3.4e-05 23.5 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESL10285.1 - 0.0031 16.7 0.0 0.61 9.2 0.0 2.6 2 1 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.13 ESL10285.1 - 0.012 14.9 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family OCD_Mu_crystall PF02423.10 ESL10286.1 - 0.042 12.6 0.0 0.054 12.2 0.0 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family DNA_pol_A_exo1 PF01612.15 ESL10287.1 - 8.8e-15 54.6 0.0 1.4e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease zf-CCHC PF00098.18 ESL10287.1 - 7.1e-07 28.8 32.5 0.0014 18.4 1.6 4.6 4 1 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.1 ESL10287.1 - 0.43 10.2 30.6 0.22 11.2 1.4 4.2 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_6 PF15288.1 ESL10287.1 - 0.95 9.1 28.5 0.093 12.4 2.8 3.6 1 1 2 3 3 3 0 Zinc knuckle KIX PF02172.11 ESL10291.1 - 0.12 12.4 0.1 0.5 10.4 0.0 2.0 3 0 0 3 3 3 0 KIX domain Nudix_N_2 PF14803.1 ESL10292.1 - 5.1 6.8 11.8 1.7 8.3 0.1 3.4 3 0 0 3 3 3 0 Nudix N-terminal Zn_Tnp_IS1595 PF12760.2 ESL10292.1 - 6.6 6.6 10.6 14 5.5 2.3 3.2 3 0 0 3 3 3 0 Transposase zinc-ribbon domain CorA PF01544.13 ESL10293.1 - 5.5e-09 35.4 0.0 7.4e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein COPI_assoc PF08507.5 ESL10294.1 - 6.5e-15 55.0 8.7 8.5e-15 54.6 6.0 1.2 1 0 0 1 1 1 1 COPI associated protein DUF1771 PF08590.5 ESL10297.1 - 1.7e-18 66.3 16.0 2e-18 66.1 8.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) KH_1 PF00013.24 ESL10297.1 - 2e-10 40.1 2.1 4e-10 39.1 1.5 1.5 1 0 0 1 1 1 1 KH domain Smr PF01713.16 ESL10297.1 - 1e-09 38.4 0.0 2.9e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Smr domain KH_3 PF13014.1 ESL10297.1 - 2.4e-06 27.0 0.5 4.3e-06 26.2 0.4 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 ESL10297.1 - 0.00033 20.1 2.0 0.00049 19.6 0.7 1.8 2 0 0 2 2 2 1 KH domain HdeA PF06411.6 ESL10297.1 - 0.0068 16.3 0.3 0.11 12.4 0.0 2.4 2 0 0 2 2 2 1 HdeA/HdeB family DUF4662 PF15578.1 ESL10297.1 - 0.027 14.0 0.4 0.027 14.0 0.3 1.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4662) KH_4 PF13083.1 ESL10297.1 - 0.029 14.0 1.4 0.052 13.1 0.2 2.0 2 0 0 2 2 2 0 KH domain AAA_13 PF13166.1 ESL10297.1 - 0.042 12.3 0.6 0.048 12.1 0.4 1.1 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.1 ESL10297.1 - 0.48 9.3 5.3 0.7 8.7 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2580 PF10824.3 ESL10297.1 - 1.3 9.3 8.7 0.94 9.8 1.1 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2580) TPR_14 PF13428.1 ESL10298.1 - 3.2e-05 24.1 13.5 35 5.3 0.0 8.6 6 1 2 8 8 8 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESL10298.1 - 0.02 15.0 1.1 2.4 8.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NRDE-2 PF08424.5 ESL10298.1 - 0.092 11.6 4.2 2.2 7.0 0.2 2.9 2 1 0 2 2 2 0 NRDE-2, necessary for RNA interference PRP1_N PF06424.7 ESL10298.1 - 0.11 12.8 7.8 0.13 12.5 0.2 2.3 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal UQ_con PF00179.21 ESL10299.1 - 1.3e-41 141.2 0.0 2.5e-41 140.3 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESL10299.1 - 0.0032 17.2 0.0 0.0046 16.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESL10299.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 RWD domain AAA_18 PF13238.1 ESL10301.1 - 3e-24 85.7 0.0 4.4e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL10301.1 - 7.2e-12 46.2 0.1 1.4e-11 45.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL10301.1 - 1.4e-05 24.9 0.2 0.0015 18.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESL10301.1 - 1.5e-05 25.1 0.0 3e-05 24.2 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL10301.1 - 0.00037 20.5 0.2 0.0015 18.5 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 ESL10301.1 - 0.00039 20.4 2.7 0.00086 19.3 0.2 2.2 1 1 2 3 3 3 1 AAA domain RuvB_N PF05496.7 ESL10301.1 - 0.0023 17.0 0.0 0.0033 16.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 ESL10301.1 - 0.0027 16.4 0.0 0.005 15.6 0.0 1.4 2 0 0 2 2 2 1 TIP49 C-terminus RNA_helicase PF00910.17 ESL10301.1 - 0.0036 17.4 0.0 0.0073 16.4 0.0 1.5 1 0 0 1 1 1 1 RNA helicase DUF2075 PF09848.4 ESL10301.1 - 0.0037 16.2 0.0 0.0055 15.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.7 ESL10301.1 - 0.0038 16.3 0.0 0.0082 15.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.1 ESL10301.1 - 0.0038 16.8 0.2 0.0083 15.7 0.1 1.6 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 ESL10301.1 - 0.0045 16.1 0.0 0.0063 15.6 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.1 ESL10301.1 - 0.0046 17.0 0.0 0.01 15.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 ESL10301.1 - 0.0053 16.0 0.0 0.0088 15.2 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 SKI PF01202.17 ESL10301.1 - 0.0053 16.6 1.7 0.11 12.3 1.2 2.3 1 1 0 1 1 1 1 Shikimate kinase AAA_19 PF13245.1 ESL10301.1 - 0.0057 16.3 0.1 0.014 15.1 0.1 1.6 2 0 0 2 2 1 1 Part of AAA domain NTPase_1 PF03266.10 ESL10301.1 - 0.0059 16.3 0.0 0.013 15.1 0.0 1.7 2 0 0 2 2 1 1 NTPase KAP_NTPase PF07693.9 ESL10301.1 - 0.006 15.6 0.0 0.0066 15.4 0.0 1.4 1 1 0 1 1 1 1 KAP family P-loop domain ADK PF00406.17 ESL10301.1 - 0.0083 16.0 0.1 1.8 8.4 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase Sigma54_activat PF00158.21 ESL10301.1 - 0.0098 15.3 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain T2SE PF00437.15 ESL10301.1 - 0.0098 14.8 0.1 0.018 13.9 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein IstB_IS21 PF01695.12 ESL10301.1 - 0.011 15.2 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.9 ESL10301.1 - 0.012 15.3 0.3 0.025 14.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESL10301.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.5 2 0 0 2 2 1 0 AAA domain Arch_ATPase PF01637.13 ESL10301.1 - 0.015 15.0 0.0 0.025 14.2 0.0 1.5 1 1 0 1 1 1 0 Archaeal ATPase KaiC PF06745.8 ESL10301.1 - 0.019 14.0 0.1 0.036 13.1 0.0 1.4 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.22 ESL10301.1 - 0.023 14.9 0.2 0.043 14.0 0.1 1.8 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.7 ESL10301.1 - 0.03 13.9 0.1 0.065 12.8 0.1 1.5 1 0 0 1 1 1 0 NACHT domain Thymidylate_kin PF02223.12 ESL10301.1 - 0.035 13.4 1.1 5.5 6.3 0.1 2.4 2 1 1 3 3 3 0 Thymidylate kinase MobB PF03205.9 ESL10301.1 - 0.035 13.8 0.0 0.071 12.8 0.0 1.6 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B Parvo_NS1 PF01057.12 ESL10301.1 - 0.035 12.9 0.0 0.055 12.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 SRPRB PF09439.5 ESL10301.1 - 0.042 13.0 0.1 0.098 11.8 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Sigma54_activ_2 PF14532.1 ESL10301.1 - 0.057 13.4 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain dNK PF01712.14 ESL10301.1 - 0.059 13.2 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase CoaE PF01121.15 ESL10301.1 - 0.062 12.6 0.7 3.5 6.9 0.1 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase UPF0079 PF02367.12 ESL10301.1 - 0.066 12.8 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_10 PF12846.2 ESL10301.1 - 0.072 12.5 0.3 0.13 11.6 0.2 1.8 1 1 0 1 1 1 0 AAA-like domain Miro PF08477.8 ESL10301.1 - 0.074 13.5 0.1 0.11 12.9 0.1 1.6 1 1 0 1 1 1 0 Miro-like protein AAA_26 PF13500.1 ESL10301.1 - 0.085 12.4 0.0 1.6 8.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESL10301.1 - 0.12 11.8 0.1 0.31 10.4 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family Presenilin PF01080.12 ESL10302.1 - 1e-61 208.9 23.4 4.4e-48 164.0 6.1 2.0 1 1 1 2 2 2 2 Presenilin CLP_protease PF00574.18 ESL10302.1 - 0.13 11.8 0.2 0.21 11.2 0.2 1.2 1 0 0 1 1 1 0 Clp protease Amidase PF01425.16 ESL10303.1 - 1.1e-05 24.5 0.0 0.092 11.5 0.0 2.5 2 0 0 2 2 2 2 Amidase AAA PF00004.24 ESL10304.1 - 3.3e-41 140.5 0.0 8e-41 139.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESL10304.1 - 1.3e-05 25.1 0.0 2.8e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 ESL10304.1 - 1.8e-05 24.2 0.0 3.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 ESL10304.1 - 6.1e-05 23.0 2.5 0.00042 20.3 0.2 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 ESL10304.1 - 8.8e-05 22.6 0.1 0.0017 18.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL10304.1 - 0.00013 21.7 0.0 0.00055 19.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESL10304.1 - 0.00088 18.9 0.1 0.016 14.9 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 ESL10304.1 - 0.0016 18.4 0.0 0.0049 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL10304.1 - 0.0024 17.7 0.0 0.0078 16.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL10304.1 - 0.0034 16.4 0.0 0.024 13.7 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ESL10304.1 - 0.004 17.9 0.0 0.025 15.4 0.0 2.5 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 ESL10304.1 - 0.013 15.1 0.2 0.13 11.8 0.1 2.7 1 1 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.16 ESL10304.1 - 0.015 14.5 0.0 0.044 12.9 0.0 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESL10304.1 - 0.016 13.9 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus Bromodomain PF00439.20 ESL10304.1 - 0.016 15.0 0.0 0.048 13.5 0.0 1.7 1 0 0 1 1 1 0 Bromodomain AAA_14 PF13173.1 ESL10304.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL10304.1 - 0.024 14.9 0.0 0.099 12.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 ESL10304.1 - 0.031 14.3 0.0 0.074 13.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.1 ESL10304.1 - 0.032 13.6 0.2 0.28 10.5 0.1 2.5 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL10304.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.11 ESL10304.1 - 0.061 12.5 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.12 ESL10304.1 - 0.1 11.4 0.3 0.35 9.6 0.0 1.8 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.22 ESL10304.1 - 0.12 12.7 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 ESL10305.1 - 5.8e-06 26.4 0.3 1.9e-05 24.7 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 ESL10305.1 - 1.2e-05 25.1 2.5 2.6e-05 24.1 0.0 2.3 2 1 1 3 3 3 1 AAA domain MobB PF03205.9 ESL10305.1 - 0.00049 19.8 0.0 0.00074 19.2 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.12 ESL10305.1 - 0.0015 18.1 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 ESL10305.1 - 0.0071 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 ESL10305.1 - 0.014 15.5 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESL10305.1 - 0.02 13.9 0.0 0.043 12.9 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_21 PF13304.1 ESL10305.1 - 0.022 14.7 0.0 0.026 14.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESL10305.1 - 0.022 14.3 0.1 0.092 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESL10305.1 - 0.022 14.2 0.0 0.047 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 ESL10305.1 - 0.024 15.4 0.0 0.051 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL10305.1 - 0.044 13.9 0.0 0.069 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 ESL10305.1 - 0.049 13.2 0.0 0.093 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.9 ESL10305.1 - 0.057 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 ESL10305.1 - 0.062 13.2 0.0 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.10 ESL10305.1 - 0.097 11.3 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein KTI12 PF08433.5 ESL10305.1 - 0.16 11.1 0.0 0.32 10.1 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Peptidase_M22 PF00814.20 ESL10306.1 - 1.6e-20 73.7 0.0 1.9e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family DUF2002 PF09400.5 ESL10306.1 - 0.044 13.5 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) Sugar-bind PF04198.8 ESL10306.1 - 0.11 11.3 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Putative sugar-binding domain CmcH_NodU PF02543.10 ESL10306.1 - 0.12 11.4 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Carbamoyltransferase MutS_V PF00488.16 ESL10307.1 - 7.1e-60 202.3 0.0 1.1e-59 201.7 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.15 ESL10307.1 - 3.4e-33 114.0 0.0 7.3e-33 112.9 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.13 ESL10307.1 - 2.1e-23 83.1 2.0 1.6e-17 63.9 0.1 2.3 2 0 0 2 2 2 2 MutS domain III AAA_25 PF13481.1 ESL10307.1 - 0.0028 17.0 0.1 0.029 13.7 0.0 2.4 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.22 ESL10307.1 - 0.0041 17.4 0.0 0.013 15.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 ESL10307.1 - 0.0072 15.8 0.0 0.017 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MutS_IV PF05190.13 ESL10307.1 - 0.1 12.8 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 MutS family domain IV AAA_14 PF13173.1 ESL10307.1 - 0.16 11.8 0.1 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESL10307.1 - 0.36 11.1 0.0 0.81 9.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain tRNA-synt_2 PF00152.15 ESL10311.1 - 2.2e-68 230.4 0.0 2.7e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 ESL10311.1 - 1.6e-05 24.2 0.2 0.075 12.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) HSP90 PF00183.13 ESL10312.1 - 2.6e-70 237.3 0.7 3.1e-70 237.0 0.5 1.0 1 0 0 1 1 1 1 Hsp90 protein HIT PF01230.18 ESL10313.1 - 6.7e-11 42.5 0.3 1.4e-10 41.5 0.2 1.5 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ESL10313.1 - 0.0011 19.2 0.5 0.0069 16.6 0.3 2.1 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF2042 PF09743.4 ESL10314.1 - 9.3e-88 294.0 0.0 1.5e-87 293.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) Cpn10 PF00166.16 ESL10315.1 - 2.5e-20 72.1 0.0 2.8e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Mec-17 PF05301.6 ESL10316.1 - 6.3e-32 110.0 0.1 1.4e-31 108.8 0.0 1.6 2 0 0 2 2 2 1 Touch receptor neuron protein Mec-17 FHA PF00498.21 ESL10317.1 - 5.9e-17 61.5 0.0 9.3e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 FHA domain Rotamase PF00639.16 ESL10317.1 - 1.8e-16 60.6 0.0 4.6e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 ESL10317.1 - 2.4e-08 34.2 0.0 5.7e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 PPIC-type PPIASE domain Pro_isomerase PF00160.16 ESL10318.1 - 1.5e-35 122.6 0.0 1.7e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IMS PF00817.15 ESL10319.1 - 6e-32 110.5 0.2 1.2e-31 109.5 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 ESL10319.1 - 2.4e-08 33.9 0.0 4.9e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 ESL10319.1 - 0.012 15.6 0.0 0.07 13.2 0.0 2.3 2 0 0 2 2 2 0 IMS family HHH motif MORN PF02493.15 ESL10321.1 - 6.6e-16 57.0 28.3 1.5e-07 30.7 1.1 6.0 5 1 1 6 6 6 5 MORN repeat Flagellar_rod PF05149.7 ESL10322.1 - 6.9e-107 356.9 26.5 1e-106 356.3 18.4 1.3 1 0 0 1 1 1 1 Paraflagellar rod protein SH3_1 PF00018.23 ESL10322.1 - 9.2e-14 50.5 0.0 1.6e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESL10322.1 - 7.4e-12 44.6 0.0 1.4e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESL10322.1 - 2.5e-07 30.0 0.0 4.5e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain MCC-bdg_PDZ PF10506.4 ESL10322.1 - 0.014 15.2 3.8 0.078 12.8 2.6 2.4 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF3708 PF12501.3 ESL10322.1 - 3.9 7.2 5.0 1.2 8.9 0.3 2.4 2 1 0 2 2 2 0 Phosphate ATP-binding cassette transporter Ery_res_leader1 PF08051.6 ESL10323.1 - 1.8 8.3 8.1 0.24 11.1 1.6 2.4 2 0 0 2 2 2 0 Erythromycin resistance leader peptide Clathrin_lg_ch PF01086.12 ESL10324.1 - 6.3e-08 32.8 2.3 7.7e-08 32.5 1.6 1.2 1 0 0 1 1 1 1 Clathrin light chain HemX PF04375.9 ESL10324.1 - 0.0087 14.6 4.0 0.011 14.4 2.8 1.2 1 0 0 1 1 1 1 HemX DUF1103 PF06513.6 ESL10324.1 - 0.011 15.0 4.8 0.015 14.7 3.3 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) PIN_2 PF10130.4 ESL10324.1 - 0.052 13.5 0.9 0.096 12.7 0.7 1.5 1 0 0 1 1 1 0 PIN domain DUF904 PF06005.7 ESL10324.1 - 3.9 7.8 8.6 0.41 10.9 2.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Lactamase_B PF00753.22 ESL10325.1 - 5.8e-06 26.0 1.5 1.1e-05 25.1 1.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Myosin_tail_1 PF01576.14 ESL10326.1 - 1.2e-05 23.2 7.2 1.5e-05 22.9 5.0 1.1 1 0 0 1 1 1 1 Myosin tail Lipoprotein_7 PF01540.11 ESL10326.1 - 0.0042 16.2 0.2 0.0051 15.9 0.2 1.1 1 0 0 1 1 1 1 Adhesin lipoprotein Z1 PF10593.4 ESL10326.1 - 0.0048 16.1 3.8 0.0048 16.1 2.6 1.5 1 1 0 1 1 1 1 Z1 domain IncA PF04156.9 ESL10326.1 - 0.005 16.4 8.6 0.0067 16.0 6.0 1.3 1 0 0 1 1 1 1 IncA protein TMF_TATA_bd PF12325.3 ESL10326.1 - 0.0067 16.1 8.5 0.012 15.3 5.9 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Gene66 PF02053.10 ESL10326.1 - 0.0088 15.4 0.1 0.011 15.1 0.1 1.1 1 0 0 1 1 1 1 Gene 66 (IR5) protein APG6 PF04111.7 ESL10326.1 - 0.015 14.3 4.7 0.019 14.0 3.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Phage_GPO PF05929.6 ESL10326.1 - 0.017 14.3 3.8 0.021 14.0 2.6 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF948 PF06103.6 ESL10326.1 - 0.027 14.3 1.0 0.081 12.7 0.4 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Dec-1 PF04624.9 ESL10326.1 - 0.028 14.0 4.8 0.39 10.3 3.2 2.8 2 1 0 2 2 2 0 Dec-1 repeat RsbRD_N PF14361.1 ESL10326.1 - 0.05 14.0 3.6 0.12 12.8 0.7 2.1 1 1 1 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Rab5-bind PF09311.6 ESL10326.1 - 0.068 13.0 10.9 2.1 8.2 0.1 2.2 1 1 1 2 2 2 0 Rabaptin-like protein BLOC1_2 PF10046.4 ESL10326.1 - 0.11 12.6 1.8 0.27 11.4 1.3 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 ESL10326.1 - 0.22 11.9 6.9 1.6 9.1 3.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Mod_r PF07200.8 ESL10326.1 - 0.23 11.3 8.5 0.43 10.4 5.9 1.6 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein HBS1_N PF08938.5 ESL10326.1 - 0.26 11.4 3.0 0.64 10.1 1.9 1.8 1 1 0 1 1 1 0 HBS1 N-terminus TMPIT PF07851.8 ESL10326.1 - 0.32 10.0 2.5 0.42 9.6 1.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein HAUS6_N PF14661.1 ESL10326.1 - 0.32 10.2 7.3 0.42 9.9 5.0 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus YlqD PF11068.3 ESL10326.1 - 0.43 10.6 9.8 2.1 8.3 5.2 2.1 1 1 1 2 2 2 0 YlqD protein FadA PF09403.5 ESL10326.1 - 1.3 9.0 5.9 2.3 8.2 4.1 1.4 1 1 0 1 1 1 0 Adhesion protein FadA Matrilin_ccoil PF10393.4 ESL10326.1 - 1.3 8.4 6.8 35 3.8 0.1 4.0 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin CENP-Q PF13094.1 ESL10326.1 - 1.4 8.9 10.4 1.9 8.5 7.1 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.7 ESL10326.1 - 1.4 8.7 4.9 2.7 7.7 3.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 ESL10326.1 - 3 7.9 7.3 2.8 8.0 4.2 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TAF8_C PF10406.4 ESL10326.1 - 3.8 7.6 4.8 3.2 7.8 1.1 2.3 1 1 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term Herpes_UL25 PF01499.11 ESL10326.1 - 3.9 5.6 9.5 2.3 6.4 5.4 1.4 1 1 0 1 1 1 0 Herpesvirus UL25 family FUSC PF04632.7 ESL10326.1 - 7.7 4.8 10.5 9.7 4.4 7.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ribosomal_L7Ae PF01248.21 ESL10329.1 - 1.9e-23 81.7 0.4 2.6e-23 81.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Alpha_adaptin_C PF02296.11 ESL10329.1 - 0.083 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Alpha adaptin AP2, C-terminal domain Peptidase_M16_C PF05193.16 ESL10330.1 - 1.1e-09 38.2 0.1 2.7e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ESL10330.1 - 3.7e-07 30.0 0.6 9.8e-07 28.6 0.0 2.0 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) Leo1 PF04004.8 ESL10331.1 - 6.1e-24 84.6 0.0 6.1e-24 84.6 0.0 1.9 3 0 0 3 3 3 1 Leo1-like protein Cwf_Cwc_15 PF04889.7 ESL10331.1 - 0.0066 16.1 7.2 0.011 15.4 5.0 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Nucleo_P87 PF07267.6 ESL10331.1 - 2.7 6.5 6.8 4 5.9 4.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Malate_DH PF12434.3 ESL10331.1 - 2.7 7.7 8.3 1.3 8.8 2.4 2.5 2 0 0 2 2 2 0 Malate dehydrogenase enzyme Complex1_LYR_2 PF13233.1 ESL10332.1 - 1.3e-10 41.6 2.2 1.6e-10 41.3 1.5 1.2 1 0 0 1 1 1 1 Complex1_LYR-like XH PF03469.9 ESL10332.1 - 0.0084 15.7 0.1 0.012 15.2 0.1 1.2 1 0 0 1 1 1 1 XH domain CSTF_C PF14304.1 ESL10332.1 - 0.026 13.8 0.9 0.046 13.0 0.6 1.4 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal HrpJ PF07201.6 ESL10332.1 - 0.029 14.4 1.8 0.66 9.9 0.3 2.1 2 0 0 2 2 2 0 HrpJ-like domain DUF2680 PF10925.3 ESL10332.1 - 0.29 11.0 1.7 0.3 10.9 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Rad50_zn_hook PF04423.9 ESL10332.1 - 0.35 10.3 2.2 0.62 9.5 1.5 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif CCDC-167 PF15188.1 ESL10332.1 - 0.51 10.3 3.5 1.6 8.6 1.1 2.2 1 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Peptidase_M41 PF01434.13 ESL10333.1 - 5e-45 153.5 0.1 7e-45 153.1 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESL10333.1 - 2.6e-40 137.6 0.0 6.3e-40 136.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL10333.1 - 5.4e-05 23.3 1.4 0.0039 17.3 0.1 3.5 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.1 ESL10333.1 - 0.00015 21.2 1.2 0.0016 17.8 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 ESL10333.1 - 0.00029 21.6 0.0 0.00092 20.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL10333.1 - 0.00039 20.1 0.2 0.0018 17.9 0.1 2.2 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 ESL10333.1 - 0.00042 20.0 0.1 0.0023 17.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESL10333.1 - 0.0013 17.8 0.0 0.0033 16.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL10333.1 - 0.0017 18.3 5.3 0.073 13.0 3.7 3.4 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.8 ESL10333.1 - 0.0077 14.9 0.0 0.013 14.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESL10333.1 - 0.016 14.6 0.4 0.039 13.3 0.3 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.7 ESL10333.1 - 0.019 14.0 0.1 0.045 12.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.1 ESL10333.1 - 0.02 14.8 0.0 0.048 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESL10333.1 - 0.048 12.6 0.1 0.078 11.9 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.1 ESL10333.1 - 0.095 12.5 0.0 0.37 10.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL10333.1 - 0.099 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESL10333.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Peptidase_M50B PF13398.1 ESL10333.1 - 0.1 11.9 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like AAA_2 PF07724.9 ESL10333.1 - 0.14 12.0 0.1 0.97 9.3 0.1 2.4 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.7 ESL10333.1 - 0.24 11.0 1.8 0.7 9.5 0.3 2.5 3 0 0 3 3 3 0 NACHT domain Trm112p PF03966.11 ESL10335.1 - 1e-11 45.0 0.0 1.7e-11 44.3 0.0 1.3 1 1 0 1 1 1 1 Trm112p-like protein Baculo_p74 PF04583.7 ESL10335.1 - 0.075 12.2 0.0 0.083 12.0 0.0 1.1 1 0 0 1 1 1 0 Baculoviridae p74 conserved region A2L_zn_ribbon PF08792.5 ESL10335.1 - 0.17 11.4 3.1 0.88 9.1 0.0 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-RING_4 PF14570.1 ESL10335.1 - 0.4 10.3 0.1 0.4 10.3 0.0 2.5 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain CSD PF00313.17 ESL10336.1 - 0.0017 18.0 0.1 0.0046 16.7 0.1 1.7 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 ESL10336.1 - 0.0045 16.4 0.1 0.011 15.2 0.1 1.7 1 0 0 1 1 1 1 Ribonuclease B OB domain YjgF_endoribonc PF14588.1 ESL10337.1 - 2.8e-30 105.2 0.4 3.2e-30 105.0 0.3 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.16 ESL10337.1 - 4.4e-28 97.4 0.4 5.7e-28 97.0 0.3 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP FTSW_RODA_SPOVE PF01098.14 ESL10337.1 - 0.12 11.1 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Cell cycle protein YbaB_DNA_bd PF02575.11 ESL10339.1 - 0.028 14.3 0.0 4.6 7.1 0.1 2.5 2 0 0 2 2 2 0 YbaB/EbfC DNA-binding family DUF814 PF05670.8 ESL10340.1 - 4.7e-23 80.8 0.1 1.5e-22 79.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF814) CmcH_NodU PF02543.10 ESL10340.1 - 0.099 11.7 1.5 0.12 11.4 1.0 1.1 1 0 0 1 1 1 0 Carbamoyltransferase DUF2215 PF10225.4 ESL10340.1 - 0.69 9.3 3.1 0.92 8.9 2.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Mgr1 PF08602.5 ESL10340.1 - 1.5 7.7 0.0 1.5 7.7 0.0 2.0 1 1 1 2 2 2 0 Mgr1-like, i-AAA protease complex subunit BCS1_N PF08740.6 ESL10341.1 - 4.6e-37 127.4 1.1 6.6e-37 126.9 0.8 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 ESL10341.1 - 0.0016 18.5 0.0 0.0036 17.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESL10341.1 - 0.035 13.8 0.0 0.12 12.1 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain AAA_33 PF13671.1 ESL10341.1 - 0.086 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESL10341.1 - 0.089 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESL10341.1 - 0.13 13.0 0.0 0.35 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESL10341.1 - 0.22 10.1 0.0 0.34 9.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus B9-C2 PF07162.6 ESL10343.1 - 1.3e-47 161.7 0.0 1.4e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein zf-CCHC_3 PF13917.1 ESL10344.1 - 1.7e-15 56.4 2.1 3.1e-15 55.6 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle Pkinase PF00069.20 ESL10345.1 - 2.6e-74 249.6 0.0 3.3e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10345.1 - 3.2e-41 141.1 0.0 4e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10345.1 - 3.5e-07 29.4 0.0 8.5e-07 28.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESL10345.1 - 6.9e-05 22.2 0.3 0.0003 20.1 0.1 1.8 1 1 1 2 2 2 1 RIO1 family APH PF01636.18 ESL10345.1 - 0.0024 17.6 0.0 0.015 15.0 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL10345.1 - 0.003 16.6 0.0 0.0052 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.4 ESL10345.1 - 0.13 10.7 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Pro_isomerase PF00160.16 ESL10346.1 - 8.3e-47 159.2 0.1 9.6e-47 159.0 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BT1 PF03092.11 ESL10347.1 - 0.0099 14.6 0.4 0.011 14.5 0.3 1.1 1 0 0 1 1 1 1 BT1 family CTP_transf_1 PF01148.15 ESL10347.1 - 0.018 14.7 1.5 0.019 14.6 1.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family ESSS PF10183.4 ESL10349.1 - 1.1e-14 54.7 3.8 1.2e-14 54.5 2.7 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Actin PF00022.14 ESL10350.1 - 4.2e-10 38.6 0.0 4.4e-10 38.5 0.0 1.0 1 0 0 1 1 1 1 Actin DUF2955 PF11168.3 ESL10351.1 - 0.01 15.5 3.4 0.01 15.5 2.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2955) DUF1049 PF06305.6 ESL10351.1 - 1.5 8.3 5.9 0.8 9.2 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1049) NYD-SP28 PF14772.1 ESL10352.1 - 2.9e-08 33.7 7.8 2.9e-08 33.7 5.4 5.4 3 2 3 6 6 6 1 Sperm tail NYD-SP28_assoc PF14775.1 ESL10352.1 - 5.2e-07 29.2 6.0 5.2e-07 29.2 4.2 2.5 2 0 0 2 2 2 1 Sperm tail C-terminal domain NFRKB_winged PF14465.1 ESL10352.1 - 0.073 12.9 6.4 1.3 8.9 0.1 3.1 2 1 1 3 3 3 0 NFRKB Winged Helix-like Baculo_PEP_C PF04513.7 ESL10352.1 - 0.12 12.2 7.6 2.4 7.9 0.9 3.4 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PulS_OutS PF09691.5 ESL10352.1 - 4 7.4 8.7 1.1 9.3 0.0 3.4 3 0 0 3 3 3 0 Bacterial chaperone lipoprotein (PulS_OutS) TP_methylase PF00590.15 ESL10353.1 - 2e-22 79.9 0.1 1.1e-21 77.5 0.1 2.1 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF1935 PF09149.5 ESL10354.1 - 4.7e-30 103.6 0.0 8.4e-30 102.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) META PF03724.11 ESL10354.1 - 2.9e-20 71.9 5.1 1.7e-06 27.7 0.1 3.4 3 0 0 3 3 3 3 META domain DHC_N2 PF08393.8 ESL10355.1 - 1.4e-125 419.0 7.8 1.4e-125 419.0 5.4 3.2 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESL10355.1 - 3.6e-88 294.9 0.8 1.2e-86 290.0 0.1 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESL10355.1 - 4.6e-45 153.6 0.3 1.6e-44 151.8 0.1 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.2 ESL10355.1 - 2.7e-35 121.7 0.0 1.1e-34 119.8 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESL10355.1 - 3.2e-14 52.8 1.5 0.00013 21.7 0.0 7.4 6 2 0 6 6 6 2 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 ESL10355.1 - 2.7e-08 33.6 1.6 0.17 11.4 0.0 3.5 3 0 0 3 3 3 3 AAA domain AAA_22 PF13401.1 ESL10355.1 - 1.5e-07 31.6 2.8 0.13 12.3 0.0 4.9 6 0 0 6 6 3 3 AAA domain RNA_helicase PF00910.17 ESL10355.1 - 1.9e-07 31.1 0.5 0.0097 16.0 0.0 4.3 4 0 0 4 4 3 2 RNA helicase AAA PF00004.24 ESL10355.1 - 4.9e-07 30.0 1.0 0.81 9.8 0.0 5.2 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESL10355.1 - 6.2e-06 25.8 3.4 0.59 9.9 0.1 3.8 3 0 0 3 3 3 2 Part of AAA domain AAA_17 PF13207.1 ESL10355.1 - 1.5e-05 25.7 1.9 0.04 14.7 0.0 5.0 4 0 0 4 4 4 1 AAA domain Mg_chelatase PF01078.16 ESL10355.1 - 2.3e-05 23.6 3.9 0.036 13.2 0.0 5.4 6 0 0 6 6 6 1 Magnesium chelatase, subunit ChlI T2SE PF00437.15 ESL10355.1 - 2.4e-05 23.3 0.1 0.019 13.8 0.0 3.7 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_18 PF13238.1 ESL10355.1 - 0.00013 22.2 3.8 0.041 14.1 0.0 4.0 4 0 0 4 4 2 1 AAA domain AAA_25 PF13481.1 ESL10355.1 - 0.00016 21.1 3.1 0.27 10.6 0.0 4.1 3 0 0 3 3 3 1 AAA domain ResIII PF04851.10 ESL10355.1 - 0.00016 21.5 0.1 2.3 7.9 0.0 3.7 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESL10355.1 - 0.0003 20.8 5.7 2.9 7.8 0.0 6.3 7 0 0 7 7 7 1 AAA ATPase domain Zeta_toxin PF06414.7 ESL10355.1 - 0.0018 17.4 0.9 0.57 9.2 0.0 3.4 4 0 0 4 4 4 1 Zeta toxin AAA_33 PF13671.1 ESL10355.1 - 0.0024 17.7 4.1 0.95 9.3 0.0 4.8 5 0 0 5 5 4 1 AAA domain PhoH PF02562.11 ESL10355.1 - 0.0031 16.7 4.6 0.23 10.6 0.0 3.5 3 0 0 3 3 3 1 PhoH-like protein DEAD PF00270.24 ESL10355.1 - 0.0032 16.9 0.0 1.3 8.4 0.0 3.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase NACHT PF05729.7 ESL10355.1 - 0.0088 15.7 2.2 5.9 6.5 0.1 4.2 4 0 0 4 4 4 0 NACHT domain IstB_IS21 PF01695.12 ESL10355.1 - 0.016 14.5 1.1 13 5.1 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF853 PF05872.7 ESL10355.1 - 0.05 11.9 7.2 8.4 4.6 0.1 4.1 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF853) DUF3829 PF12889.2 ESL10355.1 - 0.12 11.5 4.4 0.43 9.7 3.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3829) FtsK_SpoIIIE PF01580.13 ESL10355.1 - 0.26 10.7 1.0 3.7 6.9 0.0 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family SRP54 PF00448.17 ESL10355.1 - 0.52 9.7 5.1 18 4.7 0.1 3.6 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain UPF0079 PF02367.12 ESL10355.1 - 0.68 9.5 3.2 28 4.3 0.1 3.3 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 WW PF00397.21 ESL10356.1 - 0.00043 20.0 3.2 0.0007 19.4 2.2 1.4 1 0 0 1 1 1 1 WW domain CutC PF03932.9 ESL10357.1 - 7.3e-63 211.4 2.2 8.4e-63 211.2 1.6 1.0 1 0 0 1 1 1 1 CutC family AP_endonuc_2 PF01261.19 ESL10357.1 - 1.3e-05 24.6 0.4 9.8e-05 21.7 0.3 2.1 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel Glyco_hydro_97 PF10566.4 ESL10357.1 - 0.0012 17.9 0.1 0.062 12.3 0.0 2.0 1 1 1 2 2 2 2 Glycoside hydrolase 97 MreC PF04085.9 ESL10357.1 - 0.013 14.9 0.2 0.021 14.2 0.1 1.3 1 0 0 1 1 1 0 rod shape-determining protein MreC Sel1 PF08238.7 ESL10358.1 - 1.9e-15 56.8 4.7 0.002 18.7 0.4 5.2 4 0 0 4 4 4 4 Sel1 repeat Pex14_N PF04695.8 ESL10358.1 - 4.3 7.3 7.3 11 6.0 5.0 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PhyH PF05721.8 ESL10359.1 - 4.6e-05 23.5 0.0 8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) C1_1 PF00130.17 ESL10359.1 - 0.00032 20.3 3.9 0.00094 18.8 2.7 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-UDP PF14569.1 ESL10359.1 - 0.29 10.9 4.0 0.58 9.9 2.8 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger PHD PF00628.24 ESL10359.1 - 1.8 8.3 10.4 3.7 7.3 7.2 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 ESL10359.1 - 9.2 6.0 11.2 36 4.1 7.9 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 GTP_EFTU PF00009.22 ESL10360.1 - 6.7e-56 188.7 0.0 9.1e-56 188.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL10360.1 - 3.5e-05 23.7 0.1 7.7e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 ESL10360.1 - 0.0012 19.3 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 ESL10360.1 - 0.002 17.4 0.0 0.0056 15.9 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU_D2 PF03144.20 ESL10360.1 - 0.0028 17.7 0.0 0.0065 16.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 SRPRB PF09439.5 ESL10360.1 - 0.028 13.6 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AIG1 PF04548.11 ESL10360.1 - 0.037 13.1 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family PA PF02225.17 ESL10361.1 - 7.8e-09 35.1 0.1 1.1e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 PA domain PUF PF00806.14 ESL10362.1 - 1.3e-44 147.2 11.3 7.5e-06 25.1 0.0 9.1 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Hydrolase_3 PF08282.7 ESL10362.1 - 0.28 10.7 1.5 0.39 10.2 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Glyco_hydro_31 PF01055.21 ESL10363.1 - 2.6e-141 471.4 5.8 3.2e-141 471.1 4.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 ESL10363.1 - 4.3e-16 58.5 0.1 1.3e-15 56.9 0.0 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like Lactamase_B PF00753.22 ESL10365.1 - 8.8e-12 45.0 5.1 2.7e-11 43.4 3.4 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESL10365.1 - 0.003 17.1 0.0 0.0053 16.3 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain TRAM_LAG1_CLN8 PF03798.11 ESL10366.1 - 8.9e-26 90.6 0.7 2.1e-25 89.4 0.5 1.6 1 0 0 1 1 1 1 TLC domain SAYSvFN PF10260.4 ESL10369.1 - 6.1 6.6 6.0 8.8 6.1 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized conserved domain (SAYSvFN) Sel1 PF08238.7 ESL10370.1 - 5.9e-05 23.5 9.7 0.24 12.1 0.0 4.8 4 1 0 4 4 4 2 Sel1 repeat TRH PF05438.7 ESL10370.1 - 0.12 11.8 0.2 0.26 10.6 0.1 1.5 2 0 0 2 2 2 0 Thyrotropin-releasing hormone (TRH) TPR_11 PF13414.1 ESL10370.1 - 0.47 10.1 4.6 12 5.5 0.1 3.5 3 1 0 3 3 3 0 TPR repeat DUF1154 PF06631.6 ESL10371.1 - 0.72 9.5 5.8 0.49 10.0 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) IncA PF04156.9 ESL10371.1 - 1.5 8.3 14.5 12 5.4 10.1 2.1 1 1 0 1 1 1 0 IncA protein DUF641 PF04859.7 ESL10371.1 - 3 7.6 8.2 1.4 8.6 0.4 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Syntaxin_2 PF14523.1 ESL10371.1 - 3.6 7.6 7.3 4.6 7.3 2.3 2.2 1 1 1 2 2 2 0 Syntaxin-like protein DivIC PF04977.10 ESL10371.1 - 8.1 6.0 8.7 7.4 6.1 1.0 2.6 2 1 1 3 3 3 0 Septum formation initiator Glyco_hydro_47 PF01532.15 ESL10372.1 - 3e-115 385.4 0.0 3.8e-115 385.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 TPD52 PF04201.10 ESL10373.1 - 0.00049 19.8 5.0 0.00049 19.8 3.4 2.3 1 1 1 2 2 2 1 Tumour protein D52 family Cep57_CLD PF14073.1 ESL10373.1 - 0.0082 15.9 2.2 0.0082 15.9 1.5 2.5 1 1 2 3 3 3 1 Centrosome localisation domain of Cep57 WEMBL PF05701.6 ESL10373.1 - 0.11 10.9 27.7 0.38 9.1 2.6 2.4 1 1 1 2 2 2 0 Weak chloroplast movement under blue light FliD_C PF07195.7 ESL10373.1 - 0.13 11.5 1.2 0.4 9.9 0.7 1.9 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus GAS PF13851.1 ESL10373.1 - 0.37 9.9 21.0 0.11 11.6 7.9 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.17 ESL10373.1 - 0.89 9.5 13.8 0.75 9.8 4.8 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Cauli_DNA-bind PF03310.8 ESL10373.1 - 1.3 8.9 7.4 0.083 12.7 0.9 2.0 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein DUF972 PF06156.8 ESL10373.1 - 1.4 9.2 15.7 2.8 8.3 1.5 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF4094 PF13334.1 ESL10373.1 - 1.5 9.2 10.4 0.32 11.3 0.7 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4094) TPR_MLP1_2 PF07926.7 ESL10373.1 - 3 7.5 20.6 5.8 6.6 12.1 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CorA PF01544.13 ESL10373.1 - 3.9 6.4 8.9 8.8 5.2 6.2 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ATG16 PF08614.6 ESL10373.1 - 4 7.2 23.5 2.3 7.9 7.9 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF745 PF05335.8 ESL10373.1 - 4.2 6.8 15.6 1.4 8.3 8.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF1664 PF07889.7 ESL10373.1 - 5.2 6.8 12.0 6.2 6.6 1.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2408 PF10303.4 ESL10373.1 - 9.7 6.3 12.5 0.97 9.5 2.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) Myosin_head PF00063.16 ESL10374.1 - 6.4e-77 259.1 0.1 7.2e-77 258.9 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_17 PF13207.1 ESL10374.1 - 0.0024 18.6 0.0 0.006 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESL10374.1 - 0.0033 17.5 0.1 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESL10374.1 - 0.013 15.1 0.2 0.073 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESL10374.1 - 0.018 14.1 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.24 ESL10374.1 - 0.032 14.4 0.1 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESL10374.1 - 0.073 13.3 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 ESL10374.1 - 0.12 12.0 0.0 0.33 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Pkinase PF00069.20 ESL10375.1 - 6.6e-16 58.2 0.0 1.3e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.27 ESL10375.1 - 3.4e-06 26.7 5.5 3.9e-05 23.3 0.1 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Pkinase_Tyr PF07714.12 ESL10375.1 - 0.00013 21.1 0.0 0.00028 20.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.1 ESL10375.1 - 0.067 12.6 0.2 0.35 10.2 0.1 2.1 1 1 0 1 1 1 0 PQQ-like domain zf-CGNR PF11706.3 ESL10375.1 - 0.11 11.9 0.1 0.31 10.5 0.1 1.7 1 0 0 1 1 1 0 CGNR zinc finger PQQ PF01011.16 ESL10375.1 - 0.13 11.8 0.1 14 5.4 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat PQQ_3 PF13570.1 ESL10375.1 - 9 6.7 9.3 10 6.5 0.1 3.9 4 1 1 5 5 5 0 PQQ-like domain IPP-2 PF04979.9 ESL10376.1 - 7.5e-06 26.2 0.4 0.0014 18.8 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase inhibitor 2 (IPP-2) LRR_6 PF13516.1 ESL10377.1 - 1.1e-09 37.3 1.8 3.1e-05 23.5 0.3 3.0 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.2 ESL10377.1 - 8e-06 25.3 3.4 6.9e-05 22.3 2.0 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL10377.1 - 6.5e-05 22.4 0.6 0.66 10.2 0.1 3.3 2 0 0 2 2 2 2 Leucine Rich Repeat LRR_7 PF13504.1 ESL10377.1 - 0.00057 19.6 0.7 2.4 8.7 0.1 3.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_8 PF13855.1 ESL10377.1 - 0.00097 18.8 1.6 0.0026 17.4 1.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat Pkinase PF00069.20 ESL10378.1 - 1.4e-56 191.5 0.0 1.7e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10378.1 - 1.2e-31 109.7 0.0 1.7e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL10378.1 - 0.00025 20.8 0.2 0.0063 16.2 0.2 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL10378.1 - 0.0014 17.6 0.0 0.063 12.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like TilS PF09179.6 ESL10378.1 - 0.011 15.7 0.1 2 8.5 0.0 2.8 2 0 0 2 2 2 0 TilS substrate binding domain RIO1 PF01163.17 ESL10378.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family EF-hand_1 PF00036.27 ESL10380.1 - 3.5e-27 91.5 8.8 5.1e-07 28.5 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESL10380.1 - 3.2e-26 91.2 0.3 7.1e-14 51.7 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL10380.1 - 5.7e-21 72.4 3.6 6.8e-06 25.5 0.2 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 ESL10380.1 - 2e-19 68.9 3.7 1.6e-09 37.2 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 ESL10380.1 - 6.8e-16 56.7 6.7 7e-05 21.9 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.2 ESL10380.1 - 2.9e-06 26.9 0.3 0.03 14.0 0.0 2.3 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 ESL10380.1 - 0.00011 22.0 0.3 0.026 14.4 0.0 3.2 2 2 1 3 3 3 1 EF-hand domain IFR3_antag PF14754.1 ESL10380.1 - 0.043 12.8 0.0 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Papain-like auto-proteinase UPF0154 PF03672.8 ESL10380.1 - 0.099 12.2 0.0 7.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Metallophos PF00149.23 ESL10381.1 - 1.3e-28 99.7 0.0 3.7e-28 98.2 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4224 PF13986.1 ESL10381.1 - 0.11 12.0 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) Thiolase_C PF02803.13 ESL10382.1 - 7.1e-13 48.0 0.1 1.6e-11 43.6 0.1 2.5 1 1 1 2 2 2 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 ESL10382.1 - 3.4e-08 32.8 0.1 7.9e-06 25.0 0.0 2.4 2 0 0 2 2 2 2 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 ESL10382.1 - 2.3e-06 27.3 3.2 2.6e-06 27.0 0.2 2.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 ESL10382.1 - 0.07 12.8 4.7 0.8 9.4 0.5 3.1 2 2 1 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_11 PF08241.7 ESL10388.1 - 1.8e-12 47.6 1.8 2.1e-11 44.1 1.3 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL10388.1 - 9.7e-12 44.8 0.0 1.4e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL10388.1 - 7.2e-08 32.4 1.3 1.4e-07 31.5 0.9 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL10388.1 - 2.3e-07 31.2 1.1 1.2e-06 28.9 0.8 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10388.1 - 3.3e-07 30.5 0.4 9.2e-07 29.1 0.3 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10388.1 - 5.1e-07 29.3 0.0 1e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10388.1 - 5.5e-07 30.1 5.5 1e-05 26.0 2.9 2.9 2 1 1 3 3 3 1 Methyltransferase domain CMAS PF02353.15 ESL10388.1 - 0.0047 16.0 0.2 0.019 14.0 0.0 1.9 1 1 1 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 ESL10388.1 - 0.015 14.4 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 ESL10388.1 - 0.051 12.2 0.1 0.23 10.0 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) GDA1_CD39 PF01150.12 ESL10389.1 - 2.6e-66 223.9 0.0 3.3e-66 223.5 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.11 ESL10389.1 - 0.00077 18.7 0.0 0.0039 16.4 0.0 1.9 2 0 0 2 2 2 1 Ppx/GppA phosphatase family RGS-like PF09128.6 ESL10389.1 - 0.36 10.3 1.8 0.45 9.9 0.3 1.7 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain TLD PF07534.11 ESL10391.1 - 2.1e-18 66.6 0.0 4.6e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 TLD Cmc1 PF08583.5 ESL10392.1 - 0.0004 20.0 2.5 0.00065 19.4 1.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like SEN1_N PF12726.2 ESL10392.1 - 0.057 11.4 0.0 0.07 11.1 0.0 1.1 1 0 0 1 1 1 0 SEN1 N terminal RNA_pol_Rpb5_C PF01191.14 ESL10393.1 - 6.2e-26 89.8 0.1 1e-25 89.0 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 ESL10393.1 - 4.1e-07 30.3 0.0 5e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain DUF2027 PF09640.5 ESL10393.1 - 0.084 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2027) PSP PF04046.11 ESL10394.1 - 1.4e-19 69.1 5.7 3.2e-19 68.0 3.9 1.6 1 0 0 1 1 1 1 PSP DUF382 PF04037.8 ESL10394.1 - 9.6e-13 48.0 0.0 1.1e-10 41.4 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF382) LSM PF01423.17 ESL10395.1 - 1.7e-05 24.2 0.0 2.8e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 LSM domain Spermine_synth PF01564.12 ESL10396.1 - 3.3e-76 255.4 0.0 4.1e-76 255.1 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_26 PF13659.1 ESL10396.1 - 5.3e-06 26.4 0.0 9.9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL10396.1 - 0.0014 19.1 0.0 0.0041 17.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL10396.1 - 0.0057 17.0 0.0 0.023 15.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10396.1 - 0.013 16.0 0.0 0.022 15.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 ESL10396.1 - 0.036 14.9 0.0 0.074 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PAP_assoc PF03828.14 ESL10398.1 - 3.7e-16 58.8 0.4 8.7e-16 57.6 0.3 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESL10398.1 - 0.00012 22.3 0.0 0.00026 21.2 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cpn60_TCP1 PF00118.19 ESL10399.1 - 5e-147 490.4 3.6 5.8e-147 490.2 2.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MORN PF02493.15 ESL10400.1 - 8.4e-14 50.3 29.9 4.4e-06 26.0 2.6 7.9 9 0 0 9 9 9 5 MORN repeat EF-hand_6 PF13405.1 ESL10400.1 - 0.022 14.6 0.0 4.4 7.4 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.1 ESL10400.1 - 0.068 13.3 0.1 2.8 8.1 0.0 3.1 2 1 1 3 3 3 0 EF-hand domain pair XRN_N PF03159.13 ESL10401.1 - 3.7e-72 242.5 0.0 6.2e-72 241.8 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Amastin PF07344.6 ESL10404.1 - 8.4e-13 48.2 1.3 1e-12 47.9 0.9 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein Hexokinase_1 PF00349.16 ESL10405.1 - 4.6e-64 215.5 0.1 6.9e-64 214.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 ESL10405.1 - 4.2e-58 196.4 0.1 5.9e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Propep_M14 PF02244.11 ESL10406.1 - 0.054 13.1 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Carboxypeptidase activation peptide EMG1 PF03587.9 ESL10407.1 - 1.3e-73 246.6 0.0 1.5e-73 246.3 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase WD40 PF00400.27 ESL10408.1 - 1e-08 34.6 0.8 5.6e-06 26.0 0.2 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat Filament PF00038.16 ESL10411.1 - 7.9e-05 22.2 24.8 0.00012 21.6 17.2 1.3 1 0 0 1 1 1 1 Intermediate filament protein NPV_P10 PF05531.7 ESL10411.1 - 0.029 14.6 11.7 5.5 7.3 0.0 4.7 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 ESL10411.1 - 0.048 12.8 7.2 0.13 11.3 1.4 2.8 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF2321 PF10083.4 ESL10411.1 - 0.2 11.1 0.7 2.1 7.8 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Sipho_Gp157 PF05565.6 ESL10411.1 - 0.2 11.2 15.2 3 7.4 0.8 3.6 2 1 1 3 3 3 0 Siphovirus Gp157 PAP_central PF04928.12 ESL10411.1 - 0.33 9.7 3.9 0.62 8.8 2.7 1.4 1 0 0 1 1 1 0 Poly(A) polymerase central domain DASH_Hsk3 PF08227.6 ESL10411.1 - 0.7 10.1 0.0 0.7 10.1 0.0 3.4 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like DUF1993 PF09351.5 ESL10411.1 - 0.76 9.6 8.8 0.38 10.6 3.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) AAA_13 PF13166.1 ESL10411.1 - 0.83 8.0 14.6 0.49 8.7 8.2 1.7 1 1 1 2 2 2 0 AAA domain PCEMA1 PF07418.6 ESL10411.1 - 1 8.6 4.4 1.6 8.0 3.1 1.3 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 FlaF PF07309.6 ESL10411.1 - 1.5 8.7 10.1 0.73 9.7 2.0 3.2 2 1 1 3 3 3 0 Flagellar protein FlaF V_ATPase_I PF01496.14 ESL10411.1 - 1.5 6.6 17.2 2.3 5.9 11.9 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.3 ESL10411.1 - 1.6 7.3 6.5 2 6.9 3.6 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter Fib_alpha PF08702.5 ESL10411.1 - 4.1 7.5 17.4 6.3 6.9 3.5 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FliD_C PF07195.7 ESL10411.1 - 4.3 6.5 11.6 17 4.6 6.2 2.7 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DUF342 PF03961.8 ESL10411.1 - 5.7 5.2 17.4 0.75 8.1 4.9 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF342) Atg14 PF10186.4 ESL10411.1 - 5.8 5.7 31.5 1.4 7.7 1.2 3.2 1 1 2 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 SlyX PF04102.7 ESL10411.1 - 9.3 6.7 23.5 13 6.1 2.4 5.6 3 2 2 5 5 5 0 SlyX PCI PF01399.22 ESL10412.1 - 1.3e-20 73.6 0.1 2.7e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 PCI domain Rpn3_C PF08375.6 ESL10412.1 - 1.1e-18 67.3 0.4 2.2e-18 66.4 0.2 1.5 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal SAC3_GANP PF03399.11 ESL10412.1 - 0.047 13.2 2.0 0.18 11.3 1.4 2.0 1 1 0 1 1 1 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family HTH_27 PF13463.1 ESL10412.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain Taxilin PF09728.4 ESL10413.1 - 0.00053 19.1 11.6 0.00053 19.1 8.1 1.4 1 1 0 1 1 1 1 Myosin-like coiled-coil protein SBP_bac_6 PF13343.1 ESL10413.1 - 0.036 13.4 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein DUF932 PF06067.6 ESL10413.1 - 0.048 12.9 7.1 1.3 8.3 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF932) Tropomyosin_1 PF12718.2 ESL10413.1 - 0.11 12.3 10.5 0.05 13.4 5.0 1.9 2 0 0 2 2 2 0 Tropomyosin like RVT_thumb PF06817.9 ESL10413.1 - 0.22 11.1 2.2 0.46 10.0 1.5 1.6 1 0 0 1 1 1 0 Reverse transcriptase thumb domain COG2 PF06148.6 ESL10413.1 - 0.39 10.6 9.1 0.06 13.2 2.7 2.1 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.9 ESL10413.1 - 0.64 9.5 7.7 0.86 9.1 5.3 1.1 1 0 0 1 1 1 0 IncA protein AKAP95 PF04988.7 ESL10413.1 - 1.2 8.8 6.4 1.6 8.5 0.7 2.1 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) CCDC-167 PF15188.1 ESL10413.1 - 5.4 7.0 8.8 15 5.6 0.7 2.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF972 PF06156.8 ESL10413.1 - 5.7 7.3 8.1 2.9 8.2 3.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FlaC_arch PF05377.6 ESL10413.1 - 6.1 6.8 6.3 16 5.5 0.9 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) PRA1 PF03208.14 ESL10414.1 - 5.6e-36 123.2 7.7 6.5e-36 122.9 5.3 1.1 1 0 0 1 1 1 1 PRA1 family protein NARP1 PF12569.3 ESL10415.1 - 4.9e-88 296.1 17.8 2.5e-85 287.1 8.1 2.9 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_11 PF13414.1 ESL10415.1 - 2e-17 62.5 14.3 3.4e-06 26.6 0.0 6.1 5 1 0 5 5 5 3 TPR repeat TPR_2 PF07719.12 ESL10415.1 - 4.5e-15 54.2 24.7 2.6e-06 26.8 0.0 8.9 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESL10415.1 - 6.5e-10 38.2 16.8 4.3e-07 29.2 0.0 7.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10415.1 - 2.8e-09 36.7 21.9 0.012 16.1 0.0 9.3 6 2 5 11 11 10 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10415.1 - 2.2e-08 34.2 16.6 0.00095 19.4 0.0 5.9 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL10415.1 - 5e-07 29.0 9.1 0.029 14.1 0.0 7.4 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL10415.1 - 8.6e-07 28.6 1.4 0.013 15.6 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL10415.1 - 1.2e-06 28.3 24.0 0.0019 18.1 0.0 6.5 4 3 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL10415.1 - 1.3e-05 24.5 1.8 0.081 12.7 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL10415.1 - 0.00013 22.5 33.2 0.0028 18.2 0.0 8.7 5 3 3 9 9 9 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL10415.1 - 0.0079 16.3 23.3 0.14 12.2 0.1 5.4 6 1 0 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESL10415.1 - 0.13 12.1 7.5 0.57 10.0 0.1 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10415.1 - 0.35 11.4 18.1 0.69 10.5 0.0 6.0 7 0 0 7 7 6 0 Tetratricopeptide repeat Med10 PF09748.4 ESL10416.1 - 0.14 11.9 0.1 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex FYVE_2 PF02318.11 ESL10417.1 - 0.022 14.6 8.2 0.047 13.5 5.7 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Cyclin_N PF00134.18 ESL10420.1 - 1.4e-06 27.9 0.1 2.2e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PseudoU_synth_2 PF00849.17 ESL10422.1 - 2.7e-17 63.0 0.0 7.2e-08 32.4 0.0 3.5 3 1 0 3 3 3 2 RNA pseudouridylate synthase SET PF00856.23 ESL10423.1 - 5.8e-08 33.2 0.0 1.1e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 SET domain Ribosomal_L2_C PF03947.13 ESL10424.1 - 4.8e-18 65.2 0.2 8e-18 64.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain GPI2 PF06432.6 ESL10427.1 - 4.2e-76 255.9 8.0 4.8e-76 255.7 5.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Ketoacyl-synt_C PF02801.17 ESL10428.1 - 0.044 13.6 0.0 0.079 12.8 0.0 1.5 1 1 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain DUF1115 PF06544.7 ESL10429.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) CHAP PF05257.11 ESL10430.1 - 0.00062 19.4 0.7 0.0073 15.9 0.5 2.5 1 1 0 1 1 1 1 CHAP domain dCMP_cyt_deam_1 PF00383.17 ESL10431.1 - 3e-14 52.5 3.1 3.9e-13 48.9 2.2 2.2 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 ESL10431.1 - 0.32 10.8 5.0 1.9 8.3 3.5 2.1 1 1 0 1 1 1 0 Bd3614-like deaminase NIF PF03031.13 ESL10433.1 - 9.4e-26 90.3 0.1 1.3e-25 89.9 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.7 ESL10433.1 - 1.2e-07 31.0 0.0 1.5e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) HAD_2 PF13419.1 ESL10433.1 - 0.046 13.9 0.0 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL10433.1 - 0.13 11.7 0.0 0.53 9.8 0.0 1.7 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Pkinase PF00069.20 ESL10435.1 - 4.9e-64 215.9 0.0 1.3e-63 214.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10435.1 - 3.8e-38 131.0 0.0 1.7e-25 89.5 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESL10435.1 - 2.3e-05 23.5 0.0 0.0077 15.2 0.0 2.8 2 1 1 3 3 3 2 Kinase-like Kdo PF06293.9 ESL10435.1 - 0.0016 17.5 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESL10436.1 - 3.6e-62 209.8 0.0 1.6e-61 207.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10436.1 - 4.1e-26 91.6 0.0 5.6e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10436.1 - 4.9e-05 22.4 0.0 0.00017 20.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESL10436.1 - 0.0043 16.1 0.0 0.0082 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MORN PF02493.15 ESL10437.1 - 3.4e-22 76.7 57.6 0.00028 20.4 1.3 9.0 9 0 0 9 9 9 8 MORN repeat DUF448 PF04296.8 ESL10437.1 - 0.03 13.9 0.6 3.9 7.1 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF448) PPV_E2_N PF00508.12 ESL10437.1 - 7.6 5.6 8.9 4.4 6.4 0.9 2.3 2 0 0 2 2 2 0 E2 (early) protein, N terminal Plus-3 PF03126.13 ESL10438.1 - 0.00029 20.8 0.0 0.0013 18.7 0.0 2.0 1 1 0 1 1 1 1 Plus-3 domain FoP_duplication PF13865.1 ESL10440.1 - 1.3e-07 31.9 11.4 1.8e-06 28.2 1.1 4.1 2 2 2 4 4 4 2 C-terminal duplication domain of Friend of PRMT1 PFK PF00365.15 ESL10441.1 - 1.6e-35 122.4 2.2 2.4e-35 121.9 1.5 1.2 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.16 ESL10441.1 - 0.0005 18.9 0.0 0.00099 17.9 0.0 1.4 1 0 0 1 1 1 1 ATP-NAD kinase TMF_DNA_bd PF12329.3 ESL10442.1 - 0.00028 20.6 10.1 0.00028 20.6 7.0 7.6 5 2 3 8 8 8 1 TATA element modulatory factor 1 DNA binding VPS11_C PF12451.3 ESL10442.1 - 0.077 12.8 0.3 0.077 12.8 0.2 6.2 5 2 1 6 6 6 0 Vacuolar protein sorting protein 11 C terminal DUF3959 PF13105.1 ESL10443.1 - 0.059 12.6 0.1 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Enkurin PF13864.1 ESL10444.1 - 2.4e-23 82.1 7.3 2.4e-23 82.1 5.1 2.2 2 0 0 2 2 2 1 Calmodulin-binding MmgE_PrpD PF03972.9 ESL10444.1 - 0.048 11.8 0.3 0.066 11.3 0.2 1.2 1 0 0 1 1 1 0 MmgE/PrpD family DUF2730 PF10805.3 ESL10444.1 - 0.081 12.6 3.3 0.13 12.0 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF4407 PF14362.1 ESL10444.1 - 9.2 5.1 8.8 5.4 5.8 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) IncA PF04156.9 ESL10445.1 - 0.0076 15.8 9.7 0.012 15.2 6.7 1.2 1 0 0 1 1 1 1 IncA protein CASP_C PF08172.7 ESL10445.1 - 0.021 13.8 3.6 0.028 13.4 2.5 1.1 1 0 0 1 1 1 0 CASP C terminal Complex1_LYR_1 PF13232.1 ESL10445.1 - 0.024 14.8 0.1 2.9 8.1 0.0 2.3 1 1 1 2 2 2 0 Complex1_LYR-like DUF1664 PF07889.7 ESL10445.1 - 0.047 13.4 2.3 4.2 7.1 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.6 ESL10445.1 - 0.05 12.2 6.0 0.068 11.8 4.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.8 ESL10445.1 - 0.065 13.5 6.5 0.1 12.9 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ESL10445.1 - 0.084 13.1 8.7 0.67 10.2 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) CDC37_N PF03234.9 ESL10445.1 - 0.096 13.0 4.6 0.23 11.7 3.2 1.6 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding DivIVA PF05103.8 ESL10445.1 - 0.11 12.5 4.4 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 DivIVA protein Ran-binding PF05508.6 ESL10445.1 - 0.28 10.0 1.9 0.4 9.5 1.3 1.3 1 0 0 1 1 1 0 RanGTP-binding protein Tropomyosin_1 PF12718.2 ESL10445.1 - 0.29 10.9 8.0 1.6 8.5 4.8 2.3 1 1 1 2 2 2 0 Tropomyosin like COG2 PF06148.6 ESL10445.1 - 0.35 10.7 5.2 0.61 9.9 0.6 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Mnd1 PF03962.10 ESL10445.1 - 0.35 10.5 5.0 0.77 9.3 3.5 1.6 1 1 0 1 1 1 0 Mnd1 family ADIP PF11559.3 ESL10445.1 - 0.35 10.7 9.4 0.74 9.7 1.3 2.1 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.15 ESL10445.1 - 0.39 10.5 6.3 1.4 8.6 0.8 2.4 2 0 0 2 2 2 0 Prefoldin subunit WEMBL PF05701.6 ESL10445.1 - 0.49 8.8 8.1 0.61 8.4 5.6 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Fzo_mitofusin PF04799.8 ESL10445.1 - 0.52 9.6 4.4 2.4 7.5 0.2 2.1 1 1 1 2 2 2 0 fzo-like conserved region Med4 PF10018.4 ESL10445.1 - 0.54 9.6 4.9 1.2 8.4 3.3 1.8 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Spc24 PF08286.6 ESL10445.1 - 1 9.0 7.6 3.5 7.3 1.2 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 TBPIP PF07106.8 ESL10445.1 - 1.5 8.3 7.3 2.4 7.6 2.9 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) APG6 PF04111.7 ESL10445.1 - 3.1 6.7 9.7 4.9 6.1 0.6 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 CENP-F_leu_zip PF10473.4 ESL10445.1 - 3.2 7.6 11.0 7.3 6.4 3.4 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.1 ESL10445.1 - 3.8 6.9 10.7 2.8 7.3 1.7 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Pkinase PF00069.20 ESL10446.1 - 1.2e-56 191.7 0.0 5.6e-55 186.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10446.1 - 2.1e-22 79.4 0.0 5.4e-18 65.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESL10446.1 - 9e-06 24.8 0.0 0.00011 21.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL10446.1 - 4e-05 23.4 4.9 0.0001 22.1 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL10446.1 - 0.0087 15.1 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESL10446.1 - 0.05 13.1 0.0 0.095 12.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase KMP11 PF03037.11 ESL10447.1 - 4.6e-56 187.3 17.3 5.1e-56 187.2 12.0 1.0 1 0 0 1 1 1 1 Kinetoplastid membrane protein 11 Apolipoprotein PF01442.13 ESL10447.1 - 0.0092 15.5 4.3 0.018 14.5 3.0 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain FCH PF00611.18 ESL10447.1 - 0.012 15.7 1.9 0.012 15.7 1.3 1.9 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Lyase_8_N PF08124.6 ESL10447.1 - 0.013 14.3 1.8 0.014 14.3 1.2 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain AAA_32 PF13654.1 ESL10447.1 - 0.018 13.7 3.9 0.02 13.5 2.7 1.0 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 ESL10447.1 - 0.048 11.0 4.5 0.058 10.7 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TroA PF01297.12 ESL10447.1 - 0.056 12.6 1.9 2.3 7.3 0.1 2.0 1 1 1 2 2 2 0 Periplasmic solute binding protein family THP2 PF09432.5 ESL10447.1 - 0.059 13.2 1.7 0.073 12.9 1.2 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 Metal_resist PF13801.1 ESL10447.1 - 0.072 13.0 1.1 0.24 11.3 0.1 1.8 1 1 1 2 2 2 0 Heavy-metal resistance Brr6_like_C_C PF10104.4 ESL10447.1 - 0.089 12.3 0.5 0.096 12.1 0.4 1.1 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain FliD_C PF07195.7 ESL10447.1 - 0.15 11.3 1.9 0.24 10.6 1.3 1.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus GrpE PF01025.14 ESL10447.1 - 0.2 11.1 5.8 0.22 11.0 4.1 1.1 1 0 0 1 1 1 0 GrpE T5orf172 PF10544.4 ESL10447.1 - 0.2 12.0 2.6 0.24 11.8 1.8 1.2 1 0 0 1 1 1 0 T5orf172 domain Herpes_BLRF2 PF05812.7 ESL10447.1 - 0.29 10.9 2.2 0.38 10.5 1.6 1.3 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein DUF4404 PF14357.1 ESL10447.1 - 0.32 11.4 3.7 1.1 9.7 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) NYD-SP28 PF14772.1 ESL10447.1 - 0.36 10.9 7.3 4.1 7.5 0.2 2.4 2 1 0 2 2 2 0 Sperm tail DIOX_N PF14226.1 ESL10447.1 - 0.58 10.7 4.8 0.71 10.4 3.4 1.1 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal ARL2_Bind_BART PF11527.3 ESL10447.1 - 0.69 9.7 9.5 1.1 9.0 6.5 1.3 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART YlqD PF11068.3 ESL10447.1 - 0.7 9.9 7.4 1.6 8.8 5.2 1.5 1 1 0 1 1 1 0 YlqD protein MRP-S27 PF10037.4 ESL10447.1 - 0.73 8.6 5.9 0.76 8.6 4.1 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF2884 PF11101.3 ESL10447.1 - 0.85 8.9 8.7 2.2 7.6 0.3 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2884) DUF922 PF06037.6 ESL10447.1 - 0.96 8.7 5.4 0.81 8.9 2.8 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF922) YtxH PF12732.2 ESL10447.1 - 1.4 9.3 3.4 3.9 7.9 2.3 1.8 1 1 0 1 1 1 0 YtxH-like protein DUF1140 PF06600.6 ESL10447.1 - 1.5 8.9 5.2 2.8 8.0 3.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1140) DUF3829 PF12889.2 ESL10447.1 - 2.1 7.4 9.6 3.1 6.9 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) TipAS PF07739.8 ESL10447.1 - 6.5 7.1 9.4 1.8 8.9 2.1 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain BTB_2 PF02214.17 ESL10448.1 - 7e-11 42.1 0.0 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WW PF00397.21 ESL10449.1 - 0.0011 18.8 0.2 0.0027 17.5 0.1 1.7 1 0 0 1 1 1 1 WW domain Wzy_C PF04932.10 ESL10450.1 - 0.027 14.2 0.8 0.039 13.7 0.6 1.2 1 0 0 1 1 1 0 O-Antigen ligase ASCH PF04266.9 ESL10451.1 - 7.7e-15 55.1 0.0 2.3e-14 53.6 0.0 1.8 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.8 ESL10451.1 - 3.1e-12 46.0 8.8 6.1e-12 45.1 6.1 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DUF3552 PF12072.3 ESL10452.1 - 0.062 12.5 32.9 0.56 9.3 1.4 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF3552) DUF2452 PF10504.4 ESL10452.1 - 0.072 12.3 0.2 0.072 12.3 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2452) DUF3565 PF12088.3 ESL10452.1 - 0.21 11.3 1.4 0.33 10.7 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3565) CsbD PF05532.7 ESL10453.1 - 0.0055 16.3 0.8 2 8.1 0.1 2.8 2 0 0 2 2 2 2 CsbD-like Lipoprotein_7 PF01540.11 ESL10453.1 - 0.014 14.4 0.3 0.026 13.6 0.1 1.5 2 0 0 2 2 2 0 Adhesin lipoprotein XPA_N PF01286.13 ESL10453.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 XPA protein N-terminal DUF2163 PF09931.4 ESL10453.1 - 0.99 9.1 7.4 0.32 10.7 1.8 2.5 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2163) COG2 PF06148.6 ESL10453.1 - 1.2 9.0 22.7 2 8.3 4.3 4.3 1 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 ParB PF08775.5 ESL10453.1 - 1.2 9.5 8.0 0.6 10.4 2.3 2.5 2 1 1 3 3 3 0 ParB family Reo_sigmaC PF04582.7 ESL10453.1 - 1.7 7.7 8.1 6.7 5.7 0.1 3.3 1 1 3 4 4 4 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 ESL10453.1 - 2.8 6.2 17.4 0.21 10.0 8.0 1.9 2 0 0 2 2 2 0 AAA domain ThiF PF00899.16 ESL10454.1 - 6.2e-40 136.1 0.6 1e-39 135.4 0.1 1.6 2 0 0 2 2 2 1 ThiF family MoeZ_MoeB PF05237.8 ESL10454.1 - 1.8e-27 94.7 0.9 4e-27 93.6 0.6 1.6 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 ESL10454.1 - 2.1e-09 37.7 0.0 1.3e-08 35.1 0.0 2.2 1 1 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.15 ESL10454.1 - 0.011 15.8 0.2 0.03 14.4 0.1 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.14 ESL10454.1 - 0.073 12.1 0.5 0.12 11.4 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.13 ESL10454.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DapB_N PF01113.15 ESL10454.1 - 0.16 11.9 0.6 0.79 9.6 0.0 2.4 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus Pox_A_type_inc PF04508.7 ESL10454.1 - 0.32 10.8 2.3 0.94 9.4 1.6 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat IncA PF04156.9 ESL10457.1 - 0.0038 16.8 10.2 0.067 12.7 0.3 2.5 3 0 0 3 3 3 2 IncA protein T2SM PF04612.7 ESL10457.1 - 0.0083 15.9 0.2 0.0083 15.9 0.1 2.1 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein M YebO PF13974.1 ESL10457.1 - 0.015 15.0 0.9 0.015 15.0 0.7 2.3 2 0 0 2 2 2 0 YebO-like protein TarH PF02203.10 ESL10457.1 - 0.021 14.6 0.9 0.021 14.6 0.6 1.8 2 0 0 2 2 2 0 Tar ligand binding domain homologue DUF1469 PF07332.6 ESL10457.1 - 0.068 12.8 0.5 0.068 12.8 0.3 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) OAD_gamma PF04277.8 ESL10457.1 - 0.079 13.3 0.2 0.67 10.3 0.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SseC PF04888.7 ESL10457.1 - 0.099 11.9 0.5 0.19 11.0 0.3 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Nucleoside_tran PF01733.13 ESL10457.1 - 0.11 11.6 0.4 0.25 10.4 0.0 1.7 2 0 0 2 2 2 0 Nucleoside transporter TMF_TATA_bd PF12325.3 ESL10458.1 - 7.7e-06 25.6 16.8 7.7e-06 25.6 11.7 2.7 1 1 2 3 3 3 1 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESL10458.1 - 0.0016 18.0 23.2 0.0016 18.0 16.1 2.5 1 1 2 3 3 3 1 IncA protein POX PF07526.6 ESL10458.1 - 0.019 15.2 4.2 0.019 15.2 2.9 2.3 1 1 1 2 2 2 0 Associated with HOX TSC22 PF01166.13 ESL10458.1 - 0.024 14.5 19.7 0.043 13.7 1.7 4.2 3 1 2 5 5 5 0 TSC-22/dip/bun family gpW PF02831.10 ESL10458.1 - 0.027 14.0 1.1 0.12 11.9 0.1 2.5 2 0 0 2 2 2 0 gpW GAS PF13851.1 ESL10458.1 - 0.029 13.5 30.5 0.046 12.9 12.5 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4094 PF13334.1 ESL10458.1 - 0.03 14.7 5.9 0.03 14.7 4.1 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF4094) NPV_P10 PF05531.7 ESL10458.1 - 0.07 13.3 10.2 3.8 7.8 3.6 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein STAT_alpha PF01017.15 ESL10458.1 - 0.15 11.7 22.5 0.044 13.5 7.1 2.4 1 1 1 2 2 2 0 STAT protein, all-alpha domain Seryl_tRNA_N PF02403.17 ESL10458.1 - 0.17 11.9 30.3 0.22 11.5 10.7 3.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF3584 PF12128.3 ESL10458.1 - 0.21 8.9 23.9 0.24 8.6 16.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF1818 PF08848.6 ESL10458.1 - 0.22 11.5 7.7 3.8 7.5 2.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1818) Osmo_CC PF08946.5 ESL10458.1 - 0.26 11.3 18.2 0.96 9.5 3.3 4.0 3 1 1 4 4 3 0 Osmosensory transporter coiled coil Baculo_PEP_C PF04513.7 ESL10458.1 - 0.3 10.8 8.6 2.2 8.0 4.6 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ESL10458.1 - 0.32 10.8 16.5 0.86 9.5 0.2 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Med9 PF07544.8 ESL10458.1 - 0.5 10.1 23.7 0.46 10.2 2.2 4.0 1 1 3 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 AAA_13 PF13166.1 ESL10458.1 - 0.51 8.7 22.1 0.14 10.5 12.5 1.8 1 1 0 1 1 1 0 AAA domain Reo_sigmaC PF04582.7 ESL10458.1 - 0.55 9.3 4.8 6.6 5.8 1.4 2.1 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF745 PF05335.8 ESL10458.1 - 0.65 9.4 15.5 0.2 11.1 8.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Spc7 PF08317.6 ESL10458.1 - 1 7.9 29.2 0.38 9.3 6.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.4 ESL10458.1 - 1.2 9.0 34.2 27 4.6 5.1 3.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2803 PF10972.3 ESL10458.1 - 1.6 8.2 6.5 2.2 7.7 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2803) Uds1 PF15456.1 ESL10458.1 - 1.6 8.7 27.8 0.4 10.6 7.7 2.7 1 1 1 2 2 2 0 Up-regulated During Septation SlyX PF04102.7 ESL10458.1 - 2.2 8.6 24.4 1.8 8.9 0.9 4.3 2 2 2 4 4 4 0 SlyX CDC37_N PF03234.9 ESL10458.1 - 2.5 8.4 24.1 0.91 9.8 12.4 2.4 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding DASH_Dam1 PF08653.5 ESL10458.1 - 2.5 7.9 6.6 2.6 7.8 0.1 3.1 3 1 0 3 3 2 0 DASH complex subunit Dam1 FlaC_arch PF05377.6 ESL10458.1 - 2.5 8.0 10.4 6.2 6.8 0.1 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF812 PF05667.6 ESL10458.1 - 4.5 5.6 27.9 8.8 4.6 19.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) FliD_N PF02465.13 ESL10458.1 - 6.3 7.2 12.7 4.7 7.6 4.3 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF848 PF05852.6 ESL10458.1 - 6.4 6.6 25.0 0.21 11.4 1.6 2.8 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) BLOC1_2 PF10046.4 ESL10458.1 - 10 6.3 19.7 3.1 7.9 2.1 3.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mpv17_PMP22 PF04117.7 ESL10460.1 - 3.8e-15 55.2 0.5 3.8e-15 55.2 0.4 2.1 3 0 0 3 3 3 1 Mpv17 / PMP22 family NIF PF03031.13 ESL10461.1 - 1.7e-29 102.5 0.4 7.3e-28 97.2 0.3 2.4 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESL10461.1 - 0.039 14.1 1.1 2.9 8.0 0.0 3.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase PI3_PI4_kinase PF00454.22 ESL10463.1 - 6.3e-15 55.2 1.0 1.5e-14 54.0 0.1 2.0 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FYVE PF01363.16 ESL10463.1 - 1.7e-11 43.8 9.4 1.7e-11 43.8 6.5 2.1 2 0 0 2 2 2 1 FYVE zinc finger Pkinase PF00069.20 ESL10464.1 - 6.4e-14 51.7 0.0 1.2e-13 50.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10464.1 - 2.6e-05 23.4 0.0 5.6e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10464.1 - 0.0041 16.1 0.0 0.0065 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Ribosomal_L30 PF00327.15 ESL10465.1 - 0.0012 18.3 0.0 0.0027 17.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e OSCP PF00213.13 ESL10467.1 - 0.014 15.2 1.2 0.033 14.0 0.8 1.5 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit DUF2360 PF10152.4 ESL10467.1 - 1.3 9.3 8.5 2.3 8.5 1.4 2.4 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) SPX PF03105.14 ESL10468.1 - 2.8e-16 60.1 14.7 1.9e-11 44.2 10.2 3.2 1 1 0 1 1 1 1 SPX domain VIT1 PF01988.14 ESL10468.1 - 0.0039 16.7 0.3 0.0084 15.6 0.2 1.6 1 0 0 1 1 1 1 VIT family PhaP_Bmeg PF09602.5 ESL10468.1 - 0.097 12.4 1.7 0.16 11.7 0.3 1.8 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Sprouty PF05210.8 ESL10468.1 - 0.12 12.4 0.0 0.32 11.0 0.0 1.7 2 0 0 2 2 2 0 Sprouty protein (Spry) Cyt-b5 PF00173.23 ESL10471.1 - 7.4e-18 64.1 0.0 1e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NIPSNAP PF07978.8 ESL10473.1 - 2.2e-17 62.9 0.1 3.4e-17 62.2 0.1 1.3 1 0 0 1 1 1 1 NIPSNAP zf-RING_2 PF13639.1 ESL10474.1 - 1.8e-13 50.0 8.0 3.4e-13 49.1 5.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESL10474.1 - 5.2e-08 32.8 3.6 1e-07 31.9 2.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESL10474.1 - 1.9e-06 27.4 3.9 3.2e-06 26.6 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL10474.1 - 4.3e-06 26.6 8.5 8.5e-06 25.6 5.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL10474.1 - 8.5e-05 22.1 6.1 0.00015 21.4 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESL10474.1 - 0.00022 20.7 7.0 0.0004 19.9 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESL10474.1 - 0.00054 19.6 2.3 0.0013 18.4 1.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-Apc11 PF12861.2 ESL10474.1 - 0.0011 18.7 1.8 0.0039 16.9 1.3 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 ESL10474.1 - 3.1 7.4 12.5 0.39 10.3 5.0 2.2 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain TIP41 PF04176.8 ESL10475.1 - 2e-20 72.7 0.1 3.2e-20 72.1 0.1 1.2 1 0 0 1 1 1 1 TIP41-like family GAF_2 PF13185.1 ESL10475.1 - 1.4e-07 32.1 0.0 2.4e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.1 ESL10475.1 - 4.7e-06 26.7 0.0 8.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 GAF domain EMP70 PF02990.11 ESL10476.1 - 2.1e-96 323.4 12.4 1.2e-94 317.7 8.6 2.0 1 1 0 1 1 1 1 Endomembrane protein 70 Vma12 PF11712.3 ESL10477.1 - 0.013 15.1 1.6 0.036 13.7 1.1 1.7 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF310 PF03750.8 ESL10477.1 - 0.035 14.3 1.1 0.048 13.8 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF310) T2SF PF00482.18 ESL10477.1 - 0.05 13.5 1.3 0.092 12.6 0.9 1.5 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F DinB_2 PF12867.2 ESL10477.1 - 0.055 13.8 0.9 0.18 12.1 0.6 1.8 1 1 0 1 1 1 0 DinB superfamily HTH_29 PF13551.1 ESL10477.1 - 0.083 13.0 1.5 0.96 9.6 0.1 2.3 1 1 1 2 2 2 0 Winged helix-turn helix IncA PF04156.9 ESL10478.1 - 0.047 13.2 0.8 0.23 11.0 0.1 2.1 2 0 0 2 2 2 0 IncA protein DivIC PF04977.10 ESL10478.1 - 0.51 9.8 2.8 0.41 10.1 0.1 2.1 2 0 0 2 2 2 0 Septum formation initiator HTH_3 PF01381.17 ESL10479.1 - 3.9e-11 42.6 0.1 5.9e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 ESL10479.1 - 2.1e-06 27.7 0.9 3.8e-06 27.0 0.2 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.2 ESL10479.1 - 1.5e-05 24.9 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MBF1 PF08523.5 ESL10479.1 - 0.0004 20.3 0.7 0.0004 20.3 0.5 2.1 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_37 PF13744.1 ESL10479.1 - 0.093 12.5 0.5 0.17 11.6 0.3 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.1 ESL10479.1 - 0.1 12.2 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain ArfGap PF01412.13 ESL10480.1 - 1.6e-35 121.3 0.4 1.6e-35 121.3 0.3 2.1 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf ProQ PF04352.8 ESL10480.1 - 0.036 13.6 0.4 0.22 11.1 0.3 2.1 2 0 0 2 2 2 0 ProQ/FINO family RRN7 PF11781.3 ESL10480.1 - 0.21 11.1 1.0 0.46 10.0 0.7 1.6 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 Sec1 PF00995.18 ESL10481.1 - 1.7e-66 225.0 0.0 2e-66 224.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Suc_Fer-like PF06999.7 ESL10482.1 - 1.2e-23 84.3 1.0 1.9e-23 83.7 0.5 1.4 1 1 0 1 1 1 1 Sucrase/ferredoxin-like Phage_XkdX PF09693.5 ESL10482.1 - 0.12 11.9 0.1 0.27 10.7 0.1 1.5 1 0 0 1 1 1 0 Phage uncharacterised protein (Phage_XkdX) Aa_trans PF01490.13 ESL10483.1 - 3.9e-26 91.4 10.8 4.5e-26 91.2 7.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL10483.1 - 2e-10 40.1 10.3 2.5e-10 39.7 7.2 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESL10483.1 - 0.00029 19.4 13.4 0.00042 18.9 9.3 1.3 1 0 0 1 1 1 1 Amino acid permease Cytochrom_B_C PF00032.12 ESL10483.1 - 0.082 13.1 3.6 0.11 12.7 0.3 2.3 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD DUF1145 PF06611.7 ESL10483.1 - 0.2 11.2 0.1 0.2 11.2 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1145) Carn_acyltransf PF00755.15 ESL10484.1 - 2.5e-120 402.3 0.0 2.8e-120 402.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Nitroreductase PF00881.19 ESL10484.1 - 0.017 14.9 0.0 0.05 13.4 0.0 1.8 2 0 0 2 2 2 0 Nitroreductase family MA3 PF02847.12 ESL10485.1 - 1.5e-08 34.3 0.2 4.1e-08 32.9 0.0 1.8 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.14 ESL10485.1 - 0.00013 21.4 0.4 0.00061 19.2 0.0 2.3 2 0 0 2 2 2 1 MIF4G domain Cpn10 PF00166.16 ESL10486.1 - 2.5e-20 72.1 0.0 2.8e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit NTP_transf_2 PF01909.18 ESL10487.1 - 1.1e-05 25.6 0.0 2.7e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.14 ESL10487.1 - 0.0086 16.0 0.4 0.017 15.0 0.3 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase MTS PF05175.9 ESL10488.1 - 2.5e-13 49.7 0.1 3.8e-11 42.6 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ESL10488.1 - 9.8e-12 44.9 0.0 1.6e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10488.1 - 4.8e-10 39.2 0.0 1.3e-09 37.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESL10488.1 - 8.8e-08 31.6 0.0 1.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 ESL10488.1 - 8.8e-07 29.5 0.0 2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESL10488.1 - 2e-05 23.8 0.0 3.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 ESL10488.1 - 2.1e-05 24.0 0.0 4.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 ESL10488.1 - 3.4e-05 24.1 0.0 7.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 ESL10488.1 - 4.5e-05 23.0 0.0 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Met_10 PF02475.11 ESL10488.1 - 5.8e-05 22.7 0.0 8.7e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.5 ESL10488.1 - 0.00034 20.1 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.1 ESL10488.1 - 0.0013 18.4 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 ESL10488.1 - 0.0028 17.0 0.1 0.046 13.1 0.0 2.5 2 1 0 3 3 3 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.1 ESL10488.1 - 0.0039 16.9 0.0 0.023 14.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain TRM PF02005.11 ESL10488.1 - 0.0055 15.6 0.0 0.007 15.3 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_4 PF02390.12 ESL10488.1 - 0.0062 15.6 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.7 ESL10488.1 - 0.017 15.5 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESL10488.1 - 0.049 14.1 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 ESL10488.1 - 0.054 13.0 0.0 0.092 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FmrO PF07091.6 ESL10488.1 - 0.11 11.4 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Nic96 PF04097.9 ESL10489.1 - 7e-107 358.0 0.0 8.8e-107 357.7 0.0 1.0 1 0 0 1 1 1 1 Nup93/Nic96 Pro-MCH PF05824.7 ESL10490.1 - 0.1 12.1 0.0 0.3 10.5 0.0 1.8 1 0 0 1 1 1 0 Pro-melanin-concentrating hormone (Pro-MCH) Methyltransf_4 PF02390.12 ESL10492.1 - 2.9e-34 117.8 0.0 3.4e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESL10492.1 - 1.4e-05 25.5 0.0 5.3e-05 23.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10492.1 - 0.00026 20.6 0.0 0.00052 19.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL10492.1 - 0.0087 16.5 0.0 0.024 15.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10492.1 - 0.015 15.6 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESL10492.1 - 0.15 11.3 0.0 0.5 9.7 0.0 1.8 3 0 0 3 3 3 0 Methyltransferase small domain START PF01852.14 ESL10493.1 - 1.2e-24 86.8 0.0 2e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 START domain DUF3074 PF11274.3 ESL10493.1 - 2.1e-05 24.2 0.0 0.00036 20.2 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) SNAP PF14938.1 ESL10494.1 - 3.6e-51 173.9 25.1 4.2e-51 173.7 17.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ESL10494.1 - 0.00024 20.9 1.1 0.00024 20.9 0.8 3.4 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10494.1 - 0.0011 18.6 3.8 0.0011 18.6 2.7 4.3 1 1 1 3 3 3 1 TPR repeat Foie-gras_1 PF11817.3 ESL10494.1 - 0.093 12.1 10.0 0.45 9.9 4.2 2.6 2 1 0 2 2 2 0 Foie gras liver health family 1 TPR_7 PF13176.1 ESL10494.1 - 0.1 12.4 5.5 4.9 7.1 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10494.1 - 0.32 11.0 15.0 22 5.2 0.0 6.3 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10494.1 - 0.86 10.2 14.2 5.9 7.5 0.0 5.6 4 2 1 5 5 5 0 Tetratricopeptide repeat DHC_N2 PF08393.8 ESL10495.1 - 1.9e-26 92.5 0.1 9e-26 90.3 0.0 2.0 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 Atg14 PF10186.4 ESL10496.1 - 1.1 8.0 28.6 2.6 6.9 13.1 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Sec7 PF01369.15 ESL10499.1 - 1.7e-49 168.0 0.1 4.2e-49 166.8 0.1 1.7 1 0 0 1 1 1 1 Sec7 domain DUF1981 PF09324.5 ESL10499.1 - 1.3e-21 75.9 0.1 4.6e-21 74.1 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1981) Sec7_N PF12783.2 ESL10499.1 - 1.2e-20 73.5 2.7 1.3e-20 73.5 0.2 2.4 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Radial_spoke PF04712.7 ESL10500.1 - 3.4e-112 375.7 0.0 4e-112 375.4 0.0 1.0 1 0 0 1 1 1 1 Radial spokehead-like protein DSHCT PF08148.7 ESL10501.1 - 6.1e-52 175.4 1.4 9.5e-52 174.8 0.2 1.9 2 0 0 2 2 2 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.1 ESL10501.1 - 5.5e-49 166.7 0.0 1.1e-48 165.7 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.24 ESL10501.1 - 7.7e-25 87.3 0.0 5.7e-24 84.4 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL10501.1 - 4.2e-07 29.7 0.0 1.9e-06 27.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL10501.1 - 0.00012 21.9 0.0 0.00044 20.1 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.11 ESL10501.1 - 0.00067 18.9 0.1 0.0044 16.2 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.1 ESL10501.1 - 0.00077 19.1 0.0 0.0023 17.6 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain Zot PF05707.7 ESL10501.1 - 0.0022 17.5 0.0 0.011 15.2 0.0 2.0 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) Arch_ATPase PF01637.13 ESL10501.1 - 0.0068 16.1 0.6 0.018 14.7 0.0 1.9 2 0 0 2 2 2 1 Archaeal ATPase CobA_CobO_BtuR PF02572.10 ESL10501.1 - 0.056 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP RMMBL PF07521.7 ESL10501.1 - 0.088 12.6 0.0 2.3 8.1 0.0 2.7 2 0 0 2 2 2 0 RNA-metabolising metallo-beta-lactamase DUF1664 PF07889.7 ESL10501.1 - 0.19 11.5 1.0 0.65 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Bromodomain PF00439.20 ESL10502.1 - 1.9e-15 56.5 0.0 3.1e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Mis12 PF05859.7 ESL10502.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Mis12 protein PH PF00169.24 ESL10505.1 - 8.3e-11 42.0 8.4 2.4e-05 24.4 0.6 3.9 2 2 0 2 2 2 2 PH domain Kelch_4 PF13418.1 ESL10505.1 - 5.5e-08 32.4 8.9 1.2e-05 25.0 0.0 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain PH_8 PF15409.1 ESL10505.1 - 3.5e-07 30.1 1.0 0.0014 18.6 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain Kelch_3 PF13415.1 ESL10505.1 - 5.3e-07 29.6 3.3 0.71 10.1 0.0 5.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESL10505.1 - 0.00012 21.5 3.4 0.22 11.0 0.4 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.1 ESL10505.1 - 0.0013 18.6 2.4 2.8 7.9 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 ESL10505.1 - 0.007 16.4 3.4 3.5 7.9 0.0 4.6 4 0 0 4 4 4 1 Kelch motif Ribosomal_L18e PF00828.14 ESL10506.1 - 5.5e-21 75.2 0.1 5.9e-21 75.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 SET PF00856.23 ESL10507.1 - 5.8e-05 23.4 0.2 0.00052 20.3 0.1 2.4 1 1 0 1 1 1 1 SET domain TPR_1 PF00515.23 ESL10507.1 - 0.00061 19.2 0.1 0.0018 17.8 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10507.1 - 0.047 13.6 0.1 0.19 11.7 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Myticin-prepro PF10690.4 ESL10507.1 - 0.057 13.4 4.1 5.6 7.0 0.0 2.8 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel zf-P11 PF03854.9 ESL10507.1 - 0.71 9.3 6.6 21 4.7 2.2 3.0 2 0 0 2 2 2 0 P-11 zinc finger DUF4134 PF13572.1 ESL10508.1 - 0.12 12.5 0.2 0.29 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) Yip1 PF04893.12 ESL10509.1 - 0.13 11.7 9.0 0.18 11.2 6.2 1.2 1 0 0 1 1 1 0 Yip1 domain DUF3262 PF11660.3 ESL10509.1 - 0.56 10.3 6.9 1.2 9.2 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) DUF3311 PF11755.3 ESL10509.1 - 2.4 7.7 9.8 0.64 9.6 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) MARVEL PF01284.18 ESL10509.1 - 9 6.1 13.0 18 5.0 9.0 1.7 1 1 0 1 1 1 0 Membrane-associating domain DUF3784 PF12650.2 ESL10509.1 - 9.9 6.1 10.5 6.1 6.8 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Rcd1 PF04078.8 ESL10510.1 - 4.5e-106 353.5 0.3 5.2e-106 353.2 0.2 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like V-ATPase_H_N PF03224.9 ESL10510.1 - 0.0094 15.1 0.0 0.2 10.7 0.0 2.3 1 1 0 1 1 1 1 V-ATPase subunit H MMR_HSR1 PF01926.18 ESL10511.1 - 3.9e-20 71.9 0.4 2.4e-16 59.7 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL10511.1 - 8e-07 29.0 0.1 0.17 11.6 0.0 3.3 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.13 ESL10511.1 - 1e-05 24.8 0.1 6.4e-05 22.2 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 ESL10511.1 - 0.00017 22.0 0.1 0.17 12.3 0.0 3.0 3 0 0 3 3 3 2 Miro-like protein GTP_EFTU PF00009.22 ESL10511.1 - 0.00067 19.1 0.0 1.2 8.5 0.0 3.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESL10511.1 - 0.0012 18.0 0.0 0.0029 16.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Virul_Fac PF10139.4 ESL10511.1 - 0.013 13.4 0.0 0.019 12.9 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor AAA_16 PF13191.1 ESL10511.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain SusD-like_3 PF14322.1 ESL10511.1 - 0.063 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Starch-binding associating with outer membrane MobB PF03205.9 ESL10511.1 - 0.093 12.4 0.1 0.35 10.5 0.1 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Herpes_UL52 PF03121.10 ESL10514.1 - 4.6e-14 51.9 0.1 1.8e-13 49.9 0.0 2.1 2 0 0 2 2 2 1 Herpesviridae UL52/UL70 DNA primase Tfb2 PF03849.9 ESL10515.1 - 0.0021 16.7 0.4 0.0028 16.3 0.3 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 ARGLU PF15346.1 ESL10515.1 - 0.016 14.9 7.7 0.023 14.4 5.4 1.1 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Fib_alpha PF08702.5 ESL10515.1 - 0.53 10.3 2.8 0.87 9.6 1.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RRM_1 PF00076.17 ESL10516.1 - 8.7e-16 57.3 0.0 1.6e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL10516.1 - 9.1e-13 47.9 0.0 1.8e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL10516.1 - 7.3e-08 32.1 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UBA PF00627.26 ESL10517.1 - 3.9e-08 32.9 1.1 8.9e-08 31.7 0.1 2.3 2 0 0 2 2 2 1 UBA/TS-N domain XPC-binding PF09280.6 ESL10517.1 - 1.6e-07 30.6 2.3 1.6e-07 30.6 1.6 2.2 1 1 1 2 2 2 1 XPC-binding domain ubiquitin PF00240.18 ESL10517.1 - 0.03 13.7 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Ribosomal_60s PF00428.14 ESL10517.1 - 9.7 6.6 15.5 1.1 9.6 6.1 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Lipase_3 PF01764.20 ESL10518.1 - 4.3e-11 42.5 0.0 1.2e-10 41.1 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.2 ESL10518.1 - 0.0064 16.3 0.0 0.025 14.4 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ion_trans_2 PF07885.11 ESL10520.1 - 1.7e-08 34.0 3.8 1.7e-08 34.0 2.6 2.0 2 1 0 2 2 2 1 Ion channel IQ PF00612.22 ESL10520.1 - 0.5 10.1 3.8 1.3 8.9 2.7 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif zf-CCCH PF00642.19 ESL10521.1 - 2.5e-06 27.0 1.5 4.1e-06 26.3 1.0 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESL10521.1 - 0.0082 16.1 0.5 0.044 13.7 0.4 2.2 1 1 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type Yos1 PF08571.5 ESL10522.1 - 2.5e-26 91.5 0.2 4.1e-26 90.9 0.1 1.3 1 0 0 1 1 1 1 Yos1-like SKG6 PF08693.5 ESL10523.1 - 0.22 10.8 4.5 0.58 9.5 3.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DAGK_cat PF00781.19 ESL10524.1 - 3.8e-14 52.2 0.0 5.9e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.16 ESL10524.1 - 0.00051 18.9 0.0 0.00075 18.3 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase PFK PF00365.15 ESL10524.1 - 0.04 12.8 0.1 0.1 11.5 0.0 1.6 2 0 0 2 2 2 0 Phosphofructokinase PS_pyruv_trans PF04230.8 ESL10524.1 - 0.064 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase RNase_P_pop3 PF08228.6 ESL10524.1 - 0.08 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 RNase P subunit Pop3 TP_methylase PF00590.15 ESL10524.1 - 0.091 12.4 0.1 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases MoCF_biosynth PF00994.19 ESL10524.1 - 0.13 11.6 0.0 14 5.0 0.0 2.4 2 0 0 2 2 2 0 Probable molybdopterin binding domain GATase PF00117.23 ESL10524.1 - 0.14 11.5 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I WD40 PF00400.27 ESL10525.1 - 9.6e-11 41.1 0.4 0.00075 19.2 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ResIII PF04851.10 ESL10526.1 - 3.8e-15 56.2 0.0 6.3e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESL10526.1 - 4.7e-11 42.4 0.5 1e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Helicase_C_3 PF13625.1 ESL10526.1 - 1.4e-09 37.7 0.0 5.5e-09 35.8 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESL10526.1 - 5.4e-09 35.2 0.1 3.2e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain DEAD PF00270.24 ESL10526.1 - 0.00018 21.0 0.0 0.0017 17.8 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase RNase_H2_suC PF08615.6 ESL10526.1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Peptidase_M24 PF00557.19 ESL10527.1 - 5.3e-50 169.8 0.0 7.7e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 ESL10527.1 - 3e-31 107.5 0.0 5.6e-31 106.6 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain tRNA-synt_His PF13393.1 ESL10528.1 - 7.4e-41 140.1 0.0 1.2e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 ESL10528.1 - 5.3e-14 52.1 0.0 8e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESL10528.1 - 8.7e-06 25.6 0.4 2.6e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain DNA_ligase_A_N PF04675.9 ESL10528.1 - 0.1 12.3 0.4 0.41 10.4 0.1 2.0 2 0 0 2 2 2 0 DNA ligase N terminus zf-RING_2 PF13639.1 ESL10530.1 - 3.4e-12 45.9 8.3 5.5e-12 45.3 5.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL10530.1 - 2e-11 43.7 6.7 3.1e-11 43.0 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL10530.1 - 8.9e-10 38.0 3.9 1.6e-09 37.2 2.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL10530.1 - 1.3e-09 37.6 3.2 2e-09 36.9 2.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESL10530.1 - 2.6e-09 36.8 5.9 3.9e-09 36.2 3.7 1.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESL10530.1 - 9e-09 34.9 0.7 1.6e-08 34.1 0.1 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESL10530.1 - 2e-08 33.7 4.1 3.7e-08 32.9 2.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.1 ESL10530.1 - 0.00042 20.0 4.1 0.00079 19.1 2.8 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 ESL10530.1 - 0.0013 18.5 1.4 0.0024 17.6 1.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESL10530.1 - 0.0018 18.3 7.7 0.0059 16.6 5.4 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger Prok-RING_4 PF14447.1 ESL10530.1 - 0.089 12.3 10.0 0.037 13.5 4.4 2.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.1 ESL10530.1 - 0.18 11.4 6.0 0.63 9.6 4.2 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1644 PF07800.7 ESL10530.1 - 2.2 8.1 4.9 5.3 6.8 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) Fructosamin_kin PF03881.9 ESL10531.1 - 2.6e-66 223.5 0.0 2.8e-66 223.4 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 ESL10531.1 - 5.2e-14 52.5 0.1 6.2e-14 52.3 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family APH_6_hur PF04655.9 ESL10531.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase EcKinase PF02958.15 ESL10531.1 - 0.041 13.0 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase SseB PF07179.7 ESL10532.1 - 0.0018 18.0 0.0 0.64 9.8 0.0 2.3 2 0 0 2 2 2 2 SseB protein N-terminal domain Zn_Tnp_IS1595 PF12760.2 ESL10533.1 - 0.026 14.3 3.0 8.8 6.2 0.1 3.2 3 0 0 3 3 3 0 Transposase zinc-ribbon domain DUF3716 PF12511.3 ESL10533.1 - 0.03 13.9 0.0 2.3 7.9 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3716) zf-DNL PF05180.7 ESL10533.1 - 0.051 13.2 1.6 2.5 7.9 0.1 2.9 3 0 0 3 3 3 0 DNL zinc finger DZR PF12773.2 ESL10533.1 - 0.17 11.6 1.3 4.5 7.1 0.4 2.8 2 1 0 2 2 2 0 Double zinc ribbon Mu-like_Com PF10122.4 ESL10533.1 - 0.28 10.2 1.5 25 4.0 0.0 3.3 3 0 0 3 3 3 0 Mu-like prophage protein Com Auto_anti-p27 PF06677.7 ESL10533.1 - 0.39 10.5 5.9 2.1 8.1 0.2 3.2 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Cys_rich_KTR PF14205.1 ESL10533.1 - 1.2 8.6 5.0 30 4.1 0.1 3.1 3 0 0 3 3 3 0 Cysteine-rich KTR YEATS PF03366.11 ESL10536.1 - 7.4e-11 41.6 0.0 1.3e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 YEATS family Tail_P2_I PF09684.5 ESL10536.1 - 0.054 13.0 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Phage tail protein (Tail_P2_I) ARGLU PF15346.1 ESL10537.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 GCV_T PF01571.16 ESL10538.1 - 5.6e-15 55.2 0.0 8.8e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 ESL10538.1 - 7.5e-07 29.0 0.0 1.6e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain eIF-3_zeta PF05091.7 ESL10539.1 - 1.6e-111 373.5 0.2 4.9e-110 368.5 0.1 2.0 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Nucleoplasmin PF03066.10 ESL10539.1 - 1.1 8.7 9.3 1.9 7.9 6.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin PolyA_pol PF01743.15 ESL10540.1 - 6e-26 91.1 0.0 1.2e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 ESL10540.1 - 1.8e-07 30.6 0.3 5.4e-07 29.0 0.2 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A DGF-1_5 PF11038.3 ESL10541.1 - 4.2e-18 65.5 0.0 4.2e-18 65.5 0.0 2.7 2 1 1 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESL10541.1 - 4.2e-14 52.6 14.6 1e-13 51.4 10.2 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Pkinase PF00069.20 ESL10542.1 - 4.8e-17 61.9 0.0 3.9e-16 58.9 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10542.1 - 6.2e-09 35.3 0.0 5.1e-08 32.3 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESL10542.1 - 0.0042 16.8 0.3 0.27 10.9 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL10542.1 - 0.063 12.2 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like F-box-like PF12937.2 ESL10544.1 - 0.00021 20.9 0.6 0.00038 20.1 0.4 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESL10544.1 - 0.026 14.1 0.2 0.073 12.7 0.2 1.8 1 0 0 1 1 1 0 F-box domain DUF2937 PF11157.3 ESL10544.1 - 0.082 12.2 0.7 0.13 11.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) PITH PF06201.8 ESL10545.1 - 3.3e-36 124.3 0.0 4.1e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 PITH domain NADH-u_ox-rdase PF10785.4 ESL10546.1 - 5.7e-18 64.9 1.7 5.7e-18 64.9 1.2 1.6 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF3592 PF12158.3 ESL10547.1 - 5.3e-12 45.7 0.2 6.1e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3592) Beta_helix PF13229.1 ESL10548.1 - 0.0004 20.1 0.7 0.00099 18.8 0.5 1.8 1 1 0 1 1 1 1 Right handed beta helix region DZR PF12773.2 ESL10549.1 - 0.023 14.5 6.0 0.023 14.5 4.2 6.8 4 3 0 4 4 4 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESL10549.1 - 0.074 12.2 0.1 0.074 12.2 0.1 7.2 9 1 0 9 9 9 0 zinc-ribbon domain ThiF PF00899.16 ESL10551.1 - 1.1e-12 47.9 0.0 1.9e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.14 ESL10551.1 - 0.0029 16.7 0.1 0.0041 16.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 ESL10551.1 - 0.0064 16.3 0.1 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 ESL10551.1 - 0.026 14.7 0.1 0.066 13.4 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.22 ESL10551.1 - 0.035 14.5 1.5 0.59 10.5 0.3 3.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESL10551.1 - 0.045 12.8 0.1 0.074 12.1 0.1 1.3 1 0 0 1 1 1 0 Thi4 family 2-Hacid_dh_C PF02826.14 ESL10551.1 - 0.096 11.8 0.1 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 ESL10551.1 - 0.097 12.7 0.4 0.18 11.8 0.1 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Prefoldin PF02996.12 ESL10552.1 - 3.9e-19 68.4 0.4 7.4e-18 64.3 0.0 2.0 1 1 1 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.1 ESL10552.1 - 8.5e-05 22.2 0.0 0.00019 21.1 0.0 1.7 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 ESL10552.1 - 0.0063 16.2 1.6 0.24 11.1 0.0 2.2 1 1 0 2 2 2 1 Prefoldin subunit Sec8_exocyst PF04048.9 ESL10552.1 - 0.041 13.5 0.8 2.7 7.6 0.0 2.3 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain DNA_photolyase PF00875.13 ESL10552.1 - 0.066 12.9 0.1 6.5 6.4 0.0 2.1 2 0 0 2 2 2 0 DNA photolyase Vps5 PF09325.5 ESL10552.1 - 0.1 11.8 2.3 0.93 8.6 0.2 2.0 2 0 0 2 2 2 0 Vps5 C terminal like Cep57_MT_bd PF06657.8 ESL10552.1 - 0.11 12.4 1.3 2 8.3 0.1 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Pox_A_type_inc PF04508.7 ESL10552.1 - 1.3 8.9 4.0 1.4 8.8 0.2 2.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DOT1 PF08123.8 ESL10554.1 - 4.5e-16 58.7 0.2 6.6e-16 58.2 0.1 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 ESL10554.1 - 0.0001 22.3 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10554.1 - 0.00049 19.7 0.0 0.00068 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10554.1 - 0.0024 18.4 0.0 0.0032 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL10554.1 - 0.0027 17.4 0.0 0.0035 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESL10554.1 - 0.0051 15.8 0.1 0.0088 15.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_PK PF05891.7 ESL10554.1 - 0.053 12.8 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase MRP PF09387.5 ESL10555.1 - 5.3e-59 199.1 0.0 5.3e-59 199.1 0.0 1.4 2 0 0 2 2 2 1 Mitochondrial RNA binding protein MRP TPR_16 PF13432.1 ESL10556.1 - 0.0022 18.6 6.5 0.013 16.2 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10556.1 - 0.016 15.5 2.3 0.035 14.4 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10556.1 - 0.017 14.7 1.2 4.9 6.8 0.0 3.5 2 1 1 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESL10556.1 - 0.04 13.8 3.9 1.2 9.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL10556.1 - 0.043 13.7 6.9 0.1 12.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL10556.1 - 0.044 13.5 0.1 0.51 10.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESL10556.1 - 0.083 13.1 4.1 19 5.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SGT1 PF07093.6 ESL10558.1 - 0.00066 18.1 0.8 0.0058 15.0 0.0 2.3 3 0 0 3 3 3 2 SGT1 protein Rpr2 PF04032.11 ESL10559.1 - 0.076 12.8 0.1 0.16 11.8 0.0 1.5 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Yippee-Mis18 PF03226.9 ESL10559.1 - 0.1 12.6 0.7 0.82 9.7 0.5 2.2 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RRM_1 PF00076.17 ESL10560.1 - 1.9e-11 43.4 0.1 3.3e-10 39.4 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL10560.1 - 7.4e-09 35.4 0.1 6.7e-07 29.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL10560.1 - 4.3e-08 32.8 0.0 1e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-synt_ab PF00006.20 ESL10561.1 - 1.7e-64 217.3 0.1 5.7e-64 215.5 0.0 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL10561.1 - 1.7e-20 73.5 0.0 3e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESL10561.1 - 1.1e-12 47.9 0.1 2.7e-12 46.7 0.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 ESL10561.1 - 0.0021 17.4 0.3 0.0073 15.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 ESL10561.1 - 0.01 16.0 0.1 0.062 13.4 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 ESL10561.1 - 0.023 13.8 0.1 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF258 PF03193.11 ESL10561.1 - 0.061 12.4 0.1 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF2075 PF09848.4 ESL10561.1 - 0.22 10.4 0.2 2.9 6.7 0.2 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) UBA PF00627.26 ESL10562.1 - 4.1e-09 36.0 0.8 1.5e-08 34.2 0.2 2.2 2 0 0 2 2 2 1 UBA/TS-N domain ubiquitin PF00240.18 ESL10562.1 - 4.6e-08 32.3 0.0 7.1e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family CUE PF02845.11 ESL10562.1 - 0.0024 17.3 0.1 0.14 11.6 0.0 2.9 3 0 0 3 3 3 1 CUE domain CDC48_N PF02359.13 ESL10562.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain DUF4137 PF13593.1 ESL10563.1 - 1.1e-66 225.0 20.2 1.4e-66 224.7 14.0 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) BRO1 PF03097.13 ESL10564.1 - 1.3e-65 221.6 0.6 1.3e-65 221.6 0.4 2.0 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 ESL10564.1 - 1.2e-46 158.9 15.3 1.2e-46 158.9 10.6 2.3 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Peripla_BP_6 PF13458.1 ESL10565.1 - 2.5e-14 53.4 4.4 3.2e-14 53.0 3.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein DUF4447 PF14590.1 ESL10567.1 - 0.036 13.6 0.3 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4447) zf-HIT PF04438.11 ESL10569.1 - 0.05 13.2 4.8 0.11 12.2 3.3 1.6 1 0 0 1 1 1 0 HIT zinc finger BTB_2 PF02214.17 ESL10570.1 - 0.034 14.3 0.0 0.085 13.0 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain SPRY PF00622.23 ESL10570.1 - 0.088 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 SPRY domain AAA PF00004.24 ESL10571.1 - 2.3e-87 289.9 0.0 1.1e-47 161.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESL10571.1 - 4e-15 55.4 0.0 4.2e-07 29.2 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL10571.1 - 4.2e-13 49.6 1.7 3e-05 24.0 0.0 4.4 3 2 2 5 5 4 2 AAA ATPase domain AAA_5 PF07728.9 ESL10571.1 - 2.5e-11 43.4 0.1 0.00017 21.2 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESL10571.1 - 2.8e-10 40.3 0.0 2.7e-05 24.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL10571.1 - 4.8e-10 39.6 0.2 0.0022 18.1 0.0 4.3 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ESL10571.1 - 1.5e-09 37.2 0.0 4.3e-05 22.6 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_14 PF13173.1 ESL10571.1 - 3.7e-09 36.5 0.0 0.0024 17.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 ESL10571.1 - 9.8e-09 35.2 0.6 0.0042 16.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_17 PF13207.1 ESL10571.1 - 3.9e-08 34.1 0.0 0.0011 19.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESL10571.1 - 1.2e-07 31.3 0.9 0.017 14.8 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain RNA_helicase PF00910.17 ESL10571.1 - 2.4e-07 30.8 0.0 0.027 14.6 0.0 2.8 3 0 0 3 3 2 2 RNA helicase AAA_28 PF13521.1 ESL10571.1 - 2e-06 27.8 0.1 0.075 12.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.12 ESL10571.1 - 4.9e-06 26.0 0.0 0.029 13.8 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.7 ESL10571.1 - 5.1e-06 26.2 0.2 0.091 12.4 0.0 3.4 3 0 0 3 3 3 2 NACHT domain Mg_chelatase PF01078.16 ESL10571.1 - 1e-05 24.8 0.1 0.043 12.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESL10571.1 - 1.4e-05 24.0 0.0 0.11 11.2 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus Viral_helicase1 PF01443.13 ESL10571.1 - 2.7e-05 23.8 0.0 0.17 11.4 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.1 ESL10571.1 - 3.4e-05 24.1 0.0 0.12 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.22 ESL10571.1 - 6.3e-05 23.2 2.4 0.44 10.8 0.0 3.2 3 1 0 3 3 2 2 ABC transporter AAA_3 PF07726.6 ESL10571.1 - 6.7e-05 22.5 0.0 0.22 11.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ESL10571.1 - 0.00014 21.8 0.0 0.029 14.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.1 ESL10571.1 - 0.00015 21.2 3.2 1.1 8.5 0.0 4.0 2 2 1 4 4 4 2 AAA domain Vps4_C PF09336.5 ESL10571.1 - 0.00016 21.4 0.0 0.0017 18.2 0.0 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_11 PF13086.1 ESL10571.1 - 0.00021 20.9 0.0 0.12 11.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESL10571.1 - 0.00028 20.6 0.0 1.1 8.8 0.0 3.4 2 2 2 4 4 4 1 Archaeal ATPase Sigma54_activat PF00158.21 ESL10571.1 - 0.00031 20.2 0.0 0.08 12.4 0.0 3.2 4 0 0 4 4 3 1 Sigma-54 interaction domain AAA_24 PF13479.1 ESL10571.1 - 0.00031 20.3 0.3 0.092 12.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain NB-ARC PF00931.17 ESL10571.1 - 0.00047 19.1 0.0 0.23 10.2 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain Rad17 PF03215.10 ESL10571.1 - 0.00053 18.8 0.2 0.27 9.8 0.0 2.8 2 1 1 3 3 3 1 Rad17 cell cycle checkpoint protein Parvo_NS1 PF01057.12 ESL10571.1 - 0.0014 17.5 0.1 0.36 9.6 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 UPF0079 PF02367.12 ESL10571.1 - 0.0019 17.7 0.0 2.7 7.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 NTPase_1 PF03266.10 ESL10571.1 - 0.0041 16.8 0.5 1 9.0 0.0 2.9 3 0 0 3 3 3 1 NTPase DUF815 PF05673.8 ESL10571.1 - 0.005 15.8 0.0 3.1 6.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Bac_DnaA PF00308.13 ESL10571.1 - 0.0052 16.4 0.0 2.2 7.8 0.0 2.5 2 0 0 2 2 2 1 Bacterial dnaA protein ATP-synt_ab PF00006.20 ESL10571.1 - 0.018 14.5 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain KaiC PF06745.8 ESL10571.1 - 0.031 13.4 0.1 2.6 7.1 0.0 2.8 2 1 1 3 3 3 0 KaiC SKI PF01202.17 ESL10571.1 - 0.035 13.9 1.0 0.4 10.5 0.0 2.7 3 0 0 3 3 2 0 Shikimate kinase PhoH PF02562.11 ESL10571.1 - 0.063 12.4 0.3 4.2 6.5 0.0 2.8 3 0 0 3 3 3 0 PhoH-like protein AAA_30 PF13604.1 ESL10571.1 - 0.066 12.7 0.1 15 5.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain CPT PF07931.7 ESL10571.1 - 0.069 12.7 0.0 8.3 5.9 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DAP3 PF10236.4 ESL10571.1 - 0.11 11.3 0.0 6.2 5.6 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ResIII PF04851.10 ESL10571.1 - 0.13 12.0 0.0 22 4.8 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_23 PF13476.1 ESL10571.1 - 0.14 12.4 0.0 22 5.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESL10571.1 - 0.18 11.3 0.1 18 4.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 ESL10571.1 - 0.21 10.8 0.3 4.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B cobW PF02492.14 ESL10571.1 - 0.26 10.7 0.9 11 5.3 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MCM PF00493.18 ESL10573.1 - 4.2e-124 413.6 0.0 6.1e-124 413.1 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESL10573.1 - 8.6e-20 71.4 0.0 1.1e-18 67.8 0.0 2.5 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.9 ESL10573.1 - 4.9e-09 36.0 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESL10573.1 - 9.4e-08 31.4 0.1 1.1e-05 24.7 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESL10573.1 - 0.00046 19.7 0.0 0.0011 18.5 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESL10573.1 - 0.019 14.6 0.0 4.3 7.0 0.0 2.5 1 1 1 2 2 2 0 NTPase Sigma54_activat PF00158.21 ESL10573.1 - 0.029 13.8 0.2 1.3 8.5 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain Atx10homo_assoc PF09759.4 ESL10574.1 - 2.1e-27 94.8 0.0 3.5e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain GAS PF13851.1 ESL10575.1 - 6e-61 205.1 25.9 6e-61 205.1 17.9 3.0 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF167 PF02594.11 ESL10576.1 - 3.8e-13 49.1 0.2 3.6e-09 36.4 0.0 2.6 1 1 1 3 3 3 2 Uncharacterised ACR, YggU family COG1872 FH2 PF02181.18 ESL10577.1 - 1.2e-30 106.7 0.0 1.3e-30 106.5 0.0 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Pkinase PF00069.20 ESL10578.1 - 3.2e-42 144.4 0.0 4.7e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10578.1 - 3.9e-26 91.6 0.0 6.1e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-B_box PF00643.19 ESL10578.1 - 0.0071 16.2 5.3 0.0071 16.2 3.6 6.2 6 1 0 6 6 6 3 B-box zinc finger Pox_ser-thr_kin PF05445.6 ESL10578.1 - 0.013 14.3 0.1 0.019 13.7 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.15 ESL10578.1 - 0.034 13.7 0.1 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 ESL10578.1 - 0.15 11.7 0.2 0.43 10.2 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Galactosyl_T PF01762.16 ESL10579.1 - 3.3e-09 36.6 0.0 0.0015 18.1 0.0 3.7 4 0 0 4 4 4 2 Galactosyltransferase TRAM_LAG1_CLN8 PF03798.11 ESL10581.1 - 1.1e-19 70.7 17.9 1.8e-19 70.0 12.4 1.3 1 0 0 1 1 1 1 TLC domain Peptidase_C78 PF07910.8 ESL10582.1 - 2.7e-50 170.5 0.0 3.4e-50 170.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C78 Ribosomal_L2_C PF03947.13 ESL10584.1 - 1.9e-40 137.6 1.7 3.9e-40 136.6 1.0 1.6 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 ESL10584.1 - 2.5e-14 53.0 0.0 6.1e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain PSP1 PF04468.7 ESL10585.1 - 0.00012 21.9 0.1 0.00031 20.6 0.0 1.7 2 0 0 2 2 2 1 PSP1 C-terminal conserved region ADK PF00406.17 ESL10586.1 - 1.9e-43 147.9 0.0 2.9e-43 147.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESL10586.1 - 3.3e-12 47.2 0.0 7.4e-12 46.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain ADK_lid PF05191.9 ESL10586.1 - 3e-08 33.1 0.1 6e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.1 ESL10586.1 - 1.9e-07 31.4 0.2 9.9e-07 29.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESL10586.1 - 1.6e-06 28.0 0.0 9.4e-06 25.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESL10586.1 - 0.00051 19.7 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain Thymidylate_kin PF02223.12 ESL10586.1 - 0.0021 17.4 0.0 0.58 9.5 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase AAA PF00004.24 ESL10586.1 - 0.0049 17.0 0.1 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESL10586.1 - 0.006 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 NTPase T2SE PF00437.15 ESL10586.1 - 0.017 14.0 0.0 0.028 13.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 ESL10586.1 - 0.04 12.9 0.0 0.075 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.1 ESL10586.1 - 0.093 12.8 0.0 0.26 11.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.1 ESL10586.1 - 0.13 12.2 0.0 0.37 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Nt_Gln_amidase PF09764.4 ESL10587.1 - 7.3e-58 194.9 0.0 8.4e-58 194.6 0.0 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase TruD PF01142.13 ESL10588.1 - 3.6e-20 71.9 0.0 1.4e-17 63.4 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Arm PF00514.18 ESL10589.1 - 8e-08 31.8 0.3 0.0014 18.3 0.0 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESL10589.1 - 4.8e-06 26.7 0.2 7.5e-06 26.1 0.2 1.3 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.1 ESL10589.1 - 0.00072 19.9 1.3 0.003 18.0 0.0 2.6 3 1 0 3 3 3 1 HEAT-like repeat HEAT PF02985.17 ESL10589.1 - 0.0068 16.3 0.0 0.16 12.1 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat HEAT_PBS PF03130.11 ESL10589.1 - 0.054 13.9 0.8 0.64 10.6 0.2 2.8 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat AMPKBI PF04739.10 ESL10590.1 - 0.07 12.9 0.2 0.2 11.5 0.1 1.8 1 0 0 1 1 1 0 5'-AMP-activated protein kinase beta subunit, interation domain CTP_transf_2 PF01467.21 ESL10591.1 - 1.4e-14 54.4 0.0 8.3e-14 51.9 0.0 2.4 1 1 0 1 1 1 1 Cytidylyltransferase Pkinase PF00069.20 ESL10592.1 - 8.3e-79 264.3 0.0 9.4e-79 264.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10592.1 - 1.6e-41 142.1 0.0 1.9e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10592.1 - 1.5e-11 43.8 0.0 2.3e-09 36.6 0.0 2.1 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.9 ESL10592.1 - 0.00014 21.0 0.1 0.00022 20.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESL10592.1 - 0.00065 19.0 0.2 0.0011 18.4 0.1 1.3 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 ESL10592.1 - 0.013 14.1 0.0 0.017 13.7 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC APH PF01636.18 ESL10592.1 - 0.038 13.7 0.2 0.11 12.2 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF2773 PF10971.3 ESL10592.1 - 0.11 12.4 0.1 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2773) Luteo_PO PF04662.8 ESL10593.1 - 0.018 14.5 1.9 0.29 10.5 0.0 2.7 3 0 0 3 3 3 0 Luteovirus P0 protein DUF3646 PF12362.3 ESL10593.1 - 0.027 14.4 0.5 0.084 12.8 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal GreA_GreB_N PF03449.10 ESL10593.1 - 0.14 12.2 0.4 9 6.4 0.0 2.6 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal DnaJ PF00226.26 ESL10594.1 - 1.6e-09 37.3 1.2 2.8e-09 36.5 0.8 1.4 1 0 0 1 1 1 1 DnaJ domain GpcrRhopsn4 PF10192.4 ESL10594.1 - 0.03 13.4 0.3 0.042 13.0 0.2 1.1 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain 7TM-7TMR_HD PF07698.6 ESL10594.1 - 0.036 13.5 1.1 0.056 12.8 0.8 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase ATP-synt_ab PF00006.20 ESL10595.1 - 1.8e-69 233.5 0.1 2.8e-69 232.8 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL10595.1 - 0.015 15.7 0.2 0.044 14.2 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain Sugar_tr PF00083.19 ESL10596.1 - 1.1e-111 373.6 32.9 1.2e-111 373.4 22.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL10596.1 - 8e-31 107.0 28.0 8e-31 107.0 19.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 ESL10596.1 - 0.00019 19.7 3.6 0.00019 19.7 2.5 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Got1 PF04178.7 ESL10597.1 - 3.2e-32 111.1 14.5 4.2e-32 110.7 10.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF4149 PF13664.1 ESL10597.1 - 4.8 7.3 11.8 2.1 8.4 5.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) Rep_fac_C PF08542.6 ESL10598.1 - 1.2e-15 57.2 0.0 2.3e-15 56.3 0.0 1.5 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESL10598.1 - 3.9e-05 23.3 0.1 6.3e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.8 ESL10598.1 - 0.00038 19.9 0.0 0.00076 19.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF3834 PF12916.2 ESL10598.1 - 0.011 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) Rad17 PF03215.10 ESL10598.1 - 0.073 11.7 0.0 0.097 11.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF972 PF06156.8 ESL10600.1 - 0.47 10.8 5.9 2.2 8.6 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Fe-S_biosyn PF01521.15 ESL10601.1 - 2.6e-07 30.5 0.0 2.1e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis AAA_13 PF13166.1 ESL10602.1 - 0.086 11.2 18.0 0.22 9.9 9.7 2.2 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.3 ESL10602.1 - 0.11 9.8 27.9 0.012 13.0 14.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Erythro-docking PF09277.6 ESL10602.1 - 0.23 11.1 4.1 1.3 8.7 0.6 2.9 2 0 0 2 2 2 0 Erythronolide synthase, docking TMCO5 PF14992.1 ESL10602.1 - 1 8.4 22.8 0.22 10.6 12.2 2.0 2 0 0 2 2 2 0 TMCO5 family DUF1640 PF07798.6 ESL10602.1 - 1.9 8.5 25.7 0.029 14.4 8.4 3.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1640) Reo_sigmaC PF04582.7 ESL10602.1 - 8.6 5.4 8.7 2.8 7.0 0.3 2.7 2 1 1 3 3 3 0 Reovirus sigma C capsid protein WD40 PF00400.27 ESL10603.1 - 1.4e-62 205.4 28.0 3.3e-13 48.9 0.5 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESL10603.1 - 0.011 15.2 0.0 1.3 8.6 0.0 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain LMBR1 PF04791.11 ESL10604.1 - 1.4e-10 40.4 16.3 7.5e-10 37.9 9.7 2.0 2 0 0 2 2 2 2 LMBR1-like membrane protein Cys_rich_FGFR PF00839.12 ESL10605.1 - 0.075 12.9 0.6 0.075 12.9 0.4 2.3 2 1 0 2 2 2 0 Cysteine rich repeat Na_H_Exchanger PF00999.16 ESL10606.1 - 6.5e-15 54.5 20.5 8.9e-15 54.0 14.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family S4 PF01479.20 ESL10607.1 - 4.7e-07 29.1 0.0 2.3e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 S4 domain LBP_BPI_CETP_C PF02886.12 ESL10608.1 - 0.0093 15.2 0.2 0.027 13.6 0.0 1.9 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain Methyltransf_16 PF10294.4 ESL10610.1 - 1.7e-07 30.8 0.0 0.00058 19.3 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_18 PF12847.2 ESL10610.1 - 0.00097 19.7 0.1 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESL10610.1 - 0.0054 15.8 0.0 0.008 15.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 ESL10610.1 - 0.071 13.4 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESL10610.1 - 0.12 12.4 0.1 0.23 11.5 0.1 1.5 1 1 0 1 1 1 0 Methyltransferase domain Nop16 PF09420.5 ESL10612.1 - 2.7e-31 108.8 3.4 1.3e-30 106.6 2.4 1.8 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 MoCo_carrier PF12694.2 ESL10612.1 - 0.043 13.2 0.2 7.2 6.0 0.0 2.1 1 1 0 2 2 2 0 Putative molybdenum carrier PPR PF01535.15 ESL10613.1 - 0.053 13.5 0.9 0.12 12.3 0.1 2.1 2 0 0 2 2 2 0 PPR repeat Cation_efflux PF01545.16 ESL10615.1 - 5.4e-17 61.7 2.5 8.6e-17 61.1 1.7 1.4 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ESL10615.1 - 3.5 6.5 11.1 19 4.1 7.7 1.9 1 1 0 1 1 1 0 ZIP Zinc transporter BAF1_ABF1 PF04684.8 ESL10615.1 - 8.9 5.0 10.0 13 4.4 6.9 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RRM_1 PF00076.17 ESL10616.1 - 6.7e-09 35.2 0.0 1.4e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL10616.1 - 1e-08 34.9 0.0 2.6e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL10616.1 - 2.9e-06 27.0 0.0 9.7e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 ESL10616.1 - 2.3e-05 24.3 0.0 7.7e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 MBF1 PF08523.5 ESL10616.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Multiprotein bridging factor 1 DinB_2 PF12867.2 ESL10616.1 - 0.19 12.0 1.9 1.6 9.0 1.3 2.6 1 1 0 1 1 1 0 DinB superfamily ABC_membrane PF00664.18 ESL10617.1 - 1.3e-23 83.8 3.2 1.7e-23 83.3 2.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 ESL10617.1 - 9.4e-17 61.6 0.0 2.2e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL10617.1 - 2.8e-06 26.7 0.0 0.00042 19.6 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESL10617.1 - 3.2e-05 23.3 0.1 8e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ESL10617.1 - 0.0004 19.5 0.0 0.00076 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 ESL10617.1 - 0.0037 16.6 2.8 0.0056 16.1 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESL10617.1 - 0.0063 16.5 0.1 0.0063 16.5 0.1 2.4 3 0 0 3 3 2 1 AAA ATPase domain ABC_membrane_3 PF13748.1 ESL10617.1 - 0.0077 15.2 0.1 0.019 13.9 0.1 1.6 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_23 PF13476.1 ESL10617.1 - 0.022 15.1 0.0 0.022 15.1 0.0 1.5 2 0 0 2 2 1 0 AAA domain ArgK PF03308.11 ESL10617.1 - 0.027 13.2 0.1 0.048 12.4 0.1 1.3 1 0 0 1 1 1 0 ArgK protein CAP_GLY PF01302.20 ESL10617.1 - 0.049 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 CAP-Gly domain DUF87 PF01935.12 ESL10617.1 - 0.052 13.3 0.4 0.11 12.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_33 PF13671.1 ESL10617.1 - 0.053 13.3 0.3 0.2 11.5 0.2 2.0 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 ESL10617.1 - 0.075 12.9 0.0 1.1 9.1 0.0 2.1 1 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESL10617.1 - 0.1 11.9 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain MMR_HSR1 PF01926.18 ESL10617.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.7 ESL10617.1 - 0.15 11.7 0.8 1 9.0 0.1 2.6 3 0 0 3 3 2 0 NACHT domain Miro PF08477.8 ESL10617.1 - 0.19 12.2 0.0 0.43 11.0 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 ESL10617.1 - 0.23 11.2 0.0 0.47 10.2 0.0 1.5 1 0 0 1 1 1 0 Dynamin family Lipase_3 PF01764.20 ESL10618.1 - 1.1e-29 102.9 0.0 1.8e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESL10618.1 - 0.0029 17.0 0.0 0.038 13.3 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) TFIIE_alpha PF02002.12 ESL10619.1 - 0.13 11.7 0.6 0.37 10.3 0.2 1.8 2 0 0 2 2 2 0 TFIIE alpha subunit Cluap1 PF10234.4 ESL10619.1 - 3.2 6.8 6.3 2.2 7.3 0.4 2.2 2 0 0 2 2 2 0 Clusterin-associated protein-1 ubiquitin PF00240.18 ESL10620.1 - 0.00015 21.0 0.0 0.00039 19.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESL10620.1 - 0.08 12.6 0.0 0.23 11.1 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like WW PF00397.21 ESL10621.1 - 1.5e-13 50.3 7.8 2.4e-06 27.2 0.2 2.5 2 0 0 2 2 2 2 WW domain Vps53_N PF04100.7 ESL10622.1 - 3.1e-63 213.8 5.8 4.4e-63 213.3 4.0 1.1 1 0 0 1 1 1 1 Vps53-like, N-terminal COG7 PF10191.4 ESL10622.1 - 0.00074 17.5 3.3 0.0012 16.9 2.3 1.2 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) COG2 PF06148.6 ESL10622.1 - 0.029 14.2 0.4 0.12 12.2 0.3 2.1 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3626 PF12294.3 ESL10622.1 - 0.07 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3626) Rhabdo_M2 PF04785.7 ESL10623.1 - 0.016 14.2 0.1 0.033 13.2 0.1 1.5 1 1 0 1 1 1 0 Rhabdovirus matrix protein M2 zf-C3HC4_3 PF13920.1 ESL10624.1 - 2.2e-13 49.6 6.2 6.4e-13 48.1 4.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_3 PF13606.1 ESL10624.1 - 4.5e-08 32.5 0.5 0.00063 19.7 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.25 ESL10624.1 - 1.4e-06 27.7 0.3 0.02 14.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 ESL10624.1 - 1.5e-06 28.4 0.0 1.1e-05 25.6 0.0 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) zf-C3HC4_2 PF13923.1 ESL10624.1 - 3.6e-06 26.8 6.9 3.6e-06 26.8 4.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Ank_4 PF13637.1 ESL10624.1 - 1e-05 25.8 0.1 0.011 16.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL10624.1 - 0.0006 19.9 0.1 0.037 14.2 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) zf-RING_5 PF14634.1 ESL10624.1 - 0.0012 18.5 5.0 0.0045 16.6 3.4 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESL10624.1 - 0.0079 16.0 7.5 0.0079 16.0 5.2 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.1 ESL10624.1 - 0.015 14.8 6.6 0.08 12.4 4.6 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 DUF2398 PF09661.5 ESL10624.1 - 0.077 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2398) YEATS PF03366.11 ESL10627.1 - 1.1e-19 69.9 0.1 2.2e-19 68.9 0.1 1.4 1 0 0 1 1 1 1 YEATS family DUF2201_N PF13203.1 ESL10627.1 - 2 7.5 6.5 2.2 7.3 2.3 2.2 1 1 1 2 2 2 0 Putative metallopeptidase domain zf-MYND PF01753.13 ESL10630.1 - 1.2e-05 25.0 16.1 1.2e-05 25.0 11.2 2.0 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.1 ESL10630.1 - 2.1 8.2 9.1 5.3 6.9 6.3 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Methyltransf_16 PF10294.4 ESL10632.1 - 7.8e-22 77.5 0.0 4.3e-18 65.3 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_18 PF12847.2 ESL10632.1 - 0.00031 21.3 0.2 0.00063 20.3 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL10632.1 - 0.00083 18.7 0.1 0.0014 18.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.11 ESL10632.1 - 0.0031 17.1 0.0 0.0048 16.5 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.8 ESL10632.1 - 0.0043 16.2 0.2 0.0073 15.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESL10632.1 - 0.02 14.9 0.6 0.039 13.9 0.5 1.5 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_60s PF00428.14 ESL10632.1 - 1.2 9.5 6.5 4.1 7.8 4.5 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein DGF-1_C PF11040.3 ESL10634.1 - 2e-22 78.8 0.3 3.7e-22 77.9 0.2 1.5 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4227 PF14004.1 ESL10634.1 - 0.0021 17.8 0.2 0.0064 16.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4227) SHR3_chaperone PF08229.6 ESL10634.1 - 0.013 14.5 0.5 0.017 14.0 0.3 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 DUF1183 PF06682.7 ESL10634.1 - 0.1 12.1 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) SID-1_RNA_chan PF13965.1 ESL10634.1 - 8.2 4.4 11.8 16 3.5 8.2 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 COPI_assoc PF08507.5 ESL10636.1 - 8.3e-10 38.4 5.0 9.9e-10 38.2 3.5 1.1 1 0 0 1 1 1 1 COPI associated protein DUF2668 PF10873.3 ESL10636.1 - 0.4 10.8 1.6 0.67 10.1 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2668) PrgI PF12666.2 ESL10636.1 - 4.4 7.5 7.9 0.76 9.9 1.6 2.0 1 1 1 2 2 2 0 PrgI family protein DUF4149 PF13664.1 ESL10636.1 - 8.4 6.5 9.7 15 5.7 6.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) EzrA PF06160.7 ESL10637.1 - 0.0025 16.0 4.5 0.0025 16.0 3.1 4.4 2 1 2 4 4 4 1 Septation ring formation regulator, EzrA BLOC1_2 PF10046.4 ESL10637.1 - 0.011 15.8 2.8 0.011 15.8 1.9 8.0 4 4 4 8 8 8 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1515 PF07439.6 ESL10637.1 - 0.04 13.7 0.4 0.04 13.7 0.3 7.3 3 2 7 10 10 10 0 Protein of unknown function (DUF1515) Speriolin_C PF15059.1 ESL10637.1 - 0.061 13.3 1.2 3.3 7.7 0.1 2.6 2 0 0 2 2 2 0 Speriolin C-terminus TPR_MLP1_2 PF07926.7 ESL10637.1 - 5.3 6.7 125.5 0.047 13.4 4.8 7.8 3 1 4 7 7 7 0 TPR/MLP1/MLP2-like protein DUF869 PF05911.6 ESL10637.1 - 7.4 4.6 100.1 0.051 11.8 4.8 5.3 1 1 4 5 5 5 0 Plant protein of unknown function (DUF869) PAP2_C PF14360.1 ESL10638.1 - 9.8e-19 67.4 7.7 9.8e-19 67.4 5.4 3.0 3 0 0 3 3 3 1 PAP2 superfamily C-terminal DUF818 PF05677.7 ESL10639.1 - 5.5e-08 31.9 0.0 7.7e-08 31.4 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_6 PF12697.2 ESL10639.1 - 2.6e-06 27.4 0.7 7.6e-06 25.9 0.4 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL10639.1 - 1.2e-05 25.0 0.0 1.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESL10639.1 - 8.6e-05 22.2 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 ESL10639.1 - 0.00034 20.2 0.3 0.00095 18.7 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESL10639.1 - 0.00084 18.6 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2305 PF10230.4 ESL10639.1 - 0.028 13.8 0.0 0.11 11.8 0.0 1.9 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2305) PGAP1 PF07819.8 ESL10639.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein MFS_1 PF07690.11 ESL10641.1 - 1.5e-42 145.5 63.4 3.1e-36 124.8 21.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 ESL10641.1 - 0.033 14.1 13.3 0.36 10.8 0.1 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1228) Glug PF07581.7 ESL10641.1 - 0.072 13.3 2.0 4.3 7.7 0.1 3.2 2 0 0 2 2 2 0 The GLUG motif SMC_N PF02463.14 ESL10642.1 - 4.8e-73 245.0 0.5 6.3e-73 244.6 0.3 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESL10642.1 - 2.4e-20 72.6 0.0 1e-19 70.6 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 ESL10642.1 - 1.6e-14 54.5 0.1 7e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESL10642.1 - 3.4e-07 29.7 0.0 7.2e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 ESL10642.1 - 2.5e-06 26.8 5.7 0.00038 19.6 0.0 2.7 3 0 0 3 3 3 2 AAA ATPase domain AAA_23 PF13476.1 ESL10642.1 - 9.9e-05 22.7 32.4 9.9e-05 22.7 22.5 5.7 3 3 0 3 3 3 1 AAA domain ABC_tran PF00005.22 ESL10642.1 - 0.1 12.8 0.0 0.1 12.8 0.0 4.9 5 1 0 5 5 5 0 ABC transporter DUF4544 PF15077.1 ESL10642.1 - 0.4 10.1 0.0 0.4 10.1 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4544) La PF05383.12 ESL10643.1 - 9.1e-22 76.6 0.1 1.5e-21 75.9 0.1 1.4 1 0 0 1 1 1 1 La domain RRM_6 PF14259.1 ESL10643.1 - 8.5e-07 28.8 0.0 7e-06 25.9 0.0 2.4 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL10643.1 - 1.2e-06 28.0 0.0 5.6e-06 25.8 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) API5 PF05918.6 ESL10643.1 - 0.0018 16.8 2.6 0.0022 16.5 1.8 1.2 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) RRM_5 PF13893.1 ESL10643.1 - 0.042 13.6 0.3 9.7 6.1 0.1 3.3 3 1 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SseB_C PF14581.1 ESL10643.1 - 0.089 12.6 0.0 0.55 10.1 0.0 2.3 2 1 0 2 2 2 0 SseB protein C-terminal domain NAD_synthase PF02540.12 ESL10644.1 - 2e-37 128.4 0.0 2.3e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 ESL10644.1 - 0.023 14.2 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase P3A PF08727.6 ESL10645.1 - 0.068 12.5 0.0 0.2 11.0 0.0 1.8 1 0 0 1 1 1 0 Poliovirus 3A protein like LRR_6 PF13516.1 ESL10646.1 - 1.2e-19 68.0 11.9 0.063 13.3 0.0 11.3 12 0 0 12 12 12 6 Leucine Rich repeat LRR_1 PF00560.28 ESL10646.1 - 0.00054 19.6 13.8 33 5.0 0.0 9.2 9 2 0 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.1 ESL10646.1 - 0.0089 15.7 9.7 2.7 7.8 0.2 6.3 7 0 0 7 7 7 1 Leucine rich repeat GTPase_Cys_C PF12631.2 ESL10647.1 - 0.47 10.8 3.6 0.23 11.9 0.3 2.1 2 1 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE DUF2076 PF09849.4 ESL10648.1 - 2.9e-07 30.7 3.9 3.1e-07 30.6 2.7 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 ESL10648.1 - 0.0014 18.4 5.0 0.0021 17.8 3.5 1.2 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 ESL10648.1 - 0.0029 17.6 0.8 0.004 17.1 0.6 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 IncA PF04156.9 ESL10648.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 IncA protein START PF01852.14 ESL10649.1 - 3.6e-18 65.6 0.0 5.4e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 START domain Phage_int_SAM_4 PF13495.1 ESL10649.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Pkinase PF00069.20 ESL10650.1 - 8.5e-43 146.3 0.0 5.5e-42 143.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10650.1 - 4.2e-19 68.6 0.1 1.7e-14 53.5 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 ESL10650.1 - 1.2e-06 27.6 0.0 2.7e-05 23.2 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 ESL10650.1 - 0.088 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ESL10650.1 - 0.25 10.1 0.0 0.38 9.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 COG4 PF08318.7 ESL10651.1 - 1.6e-56 191.4 0.0 1.3e-53 181.9 0.0 2.1 2 0 0 2 2 2 2 COG4 transport protein RINT1_TIP1 PF04437.8 ESL10651.1 - 0.011 14.3 0.1 0.019 13.5 0.1 1.4 1 0 0 1 1 1 0 RINT-1 / TIP-1 family Flagellar_rod PF05149.7 ESL10653.1 - 1.2e-94 316.7 17.5 1.2e-94 316.7 12.1 2.3 1 1 1 2 2 2 1 Paraflagellar rod protein Baculo_PEP_C PF04513.7 ESL10653.1 - 0.36 10.6 6.3 49 3.7 0.0 4.9 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Erp_C PF06780.6 ESL10653.1 - 4.1 7.2 16.0 1.3 8.8 5.2 3.6 1 1 1 2 2 2 0 Erp protein C-terminus MMR_HSR1 PF01926.18 ESL10654.1 - 5.5e-16 58.5 0.0 8.2e-13 48.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL10654.1 - 5.7e-06 25.6 0.0 0.00011 21.5 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESL10654.1 - 0.0002 20.8 0.1 0.34 10.3 0.1 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESL10654.1 - 0.00058 19.0 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 ESL10654.1 - 0.013 15.3 0.3 0.013 15.3 0.2 2.6 2 1 1 3 3 3 0 Dynamin family Miro PF08477.8 ESL10654.1 - 0.049 14.1 0.0 0.23 11.9 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein Pkinase PF00069.20 ESL10655.1 - 1.3e-36 126.0 0.0 1.7e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10655.1 - 2.2e-17 63.0 0.0 3.5e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase IQ PF00612.22 ESL10655.1 - 0.088 12.4 2.0 0.21 11.3 1.4 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF3700 PF12481.3 ESL10655.1 - 0.15 11.2 0.0 1.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Aluminium induced protein Ca_chan_IQ PF08763.6 ESL10655.1 - 0.28 10.4 1.3 0.52 9.5 0.9 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel IQ domain Bystin PF05291.6 ESL10656.1 - 0.056 12.3 0.0 0.089 11.7 0.0 1.2 1 0 0 1 1 1 0 Bystin PUF PF00806.14 ESL10657.1 - 6.2e-15 53.7 2.3 0.23 11.0 0.0 8.3 8 0 0 8 8 8 5 Pumilio-family RNA binding repeat Death PF00531.17 ESL10657.1 - 0.04 13.6 1.1 2.3 8.0 0.1 4.0 5 0 0 5 5 5 0 Death domain Zip PF02535.17 ESL10658.1 - 6.8e-27 94.3 14.0 1.1e-26 93.5 9.7 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter HATPase_c_3 PF13589.1 ESL10659.1 - 9.6e-14 51.2 0.1 2e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 PF00183.13 ESL10659.1 - 8.9e-11 40.8 0.0 3.9e-09 35.4 0.0 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c PF02518.21 ESL10659.1 - 3.8e-07 29.7 0.0 5.4e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ski_Sno PF02437.12 ESL10659.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 SKI/SNO/DAC family HCV_NS5a_1a PF08300.8 ESL10659.1 - 0.12 12.2 0.1 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a zinc finger domain Ank_2 PF12796.2 ESL10660.1 - 2.8e-09 37.1 0.0 3.9e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL10660.1 - 1.4e-08 35.0 0.0 4.9e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 ESL10660.1 - 1e-05 25.0 0.1 0.028 14.2 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESL10660.1 - 0.00013 22.1 0.1 0.099 12.9 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL10660.1 - 0.001 19.0 0.1 0.02 15.0 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeat Bud13 PF09736.4 ESL10661.1 - 8.3e-05 22.8 6.8 0.00023 21.4 4.7 1.9 1 1 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex PP2C PF00481.16 ESL10662.1 - 8.6e-68 228.4 0.1 8.6e-68 228.4 0.0 1.8 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL10662.1 - 0.014 14.7 0.9 0.053 12.9 0.0 2.2 2 0 0 2 2 2 0 Protein phosphatase 2C TPR_10 PF13374.1 ESL10662.1 - 0.1 12.5 0.1 0.28 11.1 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat APG6 PF04111.7 ESL10662.1 - 8.4 5.3 10.9 12 4.7 7.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 UQ_con PF00179.21 ESL10663.1 - 8.9e-08 31.6 0.0 1.4e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESL10663.1 - 0.021 14.7 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 RWD domain CTF_NFI PF00859.13 ESL10664.1 - 0.067 12.9 2.0 0.1 12.3 1.4 1.2 1 0 0 1 1 1 0 CTF/NF-I family transcription modulation region CTP_transf_2 PF01467.21 ESL10666.1 - 2.1e-05 24.6 0.1 4.4e-05 23.5 0.0 1.7 2 1 0 2 2 2 1 Cytidylyltransferase 2_5_RNA_ligase2 PF13563.1 ESL10667.1 - 0.0018 18.0 0.1 0.008 15.9 0.1 2.0 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily RF-1 PF00472.15 ESL10668.1 - 6.7e-30 103.2 0.0 9.9e-30 102.6 0.0 1.3 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.13 ESL10668.1 - 1.3e-10 41.0 0.5 3.1e-10 39.7 0.3 1.8 1 1 0 1 1 1 1 PCRF domain DHHA1 PF02272.14 ESL10668.1 - 0.17 11.6 1.8 0.21 11.3 0.3 1.8 2 0 0 2 2 2 0 DHHA1 domain DEAD PF00270.24 ESL10669.1 - 4.3e-16 58.8 0.0 1.2e-11 44.3 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL10669.1 - 1.7e-13 50.2 0.0 3.8e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL10669.1 - 0.0005 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF155 PF02582.9 ESL10671.1 - 2.8e-16 59.9 0.0 4.9e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Sod_Ni PF09055.6 ESL10671.1 - 0.041 14.2 0.0 0.081 13.3 0.0 1.4 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase UTP15_C PF09384.5 ESL10672.1 - 1.4e-35 122.1 1.4 1.7e-35 121.8 0.3 1.6 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.27 ESL10672.1 - 3.2e-22 77.5 2.0 1.2e-05 24.9 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat CPSF_A PF03178.10 ESL10672.1 - 0.0003 19.9 0.0 0.0023 17.0 0.0 2.0 2 1 0 2 2 2 1 CPSF A subunit region FYVE PF01363.16 ESL10673.1 - 1.9e-14 53.3 8.3 6.4e-14 51.6 5.7 2.0 1 0 0 1 1 1 1 FYVE zinc finger Cpn60_TCP1 PF00118.19 ESL10673.1 - 2.4e-13 49.5 0.0 3.4e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family BAR_2 PF10455.4 ESL10673.1 - 0.27 10.1 0.0 0.48 9.2 0.0 1.3 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking SLBP_RNA_bind PF15247.1 ESL10675.1 - 0.012 15.3 0.8 0.043 13.5 0.5 2.0 1 0 0 1 1 1 0 Histone RNA hairpin-binding protein RNA-binding domain DUF1289 PF06945.8 ESL10675.1 - 3.7 7.0 6.3 0.33 10.4 0.3 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) DAGAT PF03982.8 ESL10677.1 - 1e-26 93.3 0.0 1.2e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Topoisom_bac PF01131.15 ESL10679.1 - 7.1e-74 249.0 0.0 1.1e-71 241.8 0.0 2.5 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 ESL10679.1 - 1.2e-13 50.8 0.0 3.8e-13 49.2 0.0 1.9 1 1 0 1 1 1 1 Toprim domain Toprim_4 PF13662.1 ESL10679.1 - 4.8e-05 23.2 0.0 0.00022 21.1 0.0 2.0 2 0 0 2 2 2 1 Toprim domain Toprim_2 PF13155.1 ESL10679.1 - 0.11 12.8 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Toprim-like Methyltransf_23 PF13489.1 ESL10680.1 - 6.5e-15 55.2 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL10680.1 - 3.1e-13 50.0 0.0 6.8e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESL10680.1 - 7.8e-10 38.2 0.0 1.2e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESL10680.1 - 2.4e-08 34.3 0.0 9.4e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL10680.1 - 2.5e-07 30.4 0.0 3.8e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10680.1 - 2.4e-06 27.8 0.0 4.7e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL10680.1 - 9.1e-06 25.6 0.1 5.2e-05 23.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10680.1 - 0.0004 20.9 0.0 0.0011 19.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESL10680.1 - 0.14 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Cpn60_TCP1 PF00118.19 ESL10681.1 - 1.3e-141 472.5 2.4 1.5e-141 472.4 1.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dpoe2NT PF12213.3 ESL10681.1 - 0.0073 16.1 0.2 0.018 14.9 0.1 1.6 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal DUF1338 PF07063.8 ESL10681.1 - 0.088 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1338) LRR_6 PF13516.1 ESL10682.1 - 8.1e-07 28.4 1.2 0.016 15.2 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_8 PF13855.1 ESL10682.1 - 0.0076 15.9 1.4 0.64 9.8 0.2 2.7 2 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 ESL10682.1 - 0.013 15.1 0.4 2 8.1 0.0 2.9 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESL10682.1 - 0.033 14.3 0.5 1.3e+02 3.5 0.0 4.1 4 0 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 ESL10682.1 - 0.055 13.5 3.0 36 4.9 0.0 3.8 3 1 1 4 4 4 0 Leucine Rich Repeat SET PF00856.23 ESL10683.1 - 1.4e-09 38.4 0.7 1.6e-08 35.0 0.5 2.1 1 1 0 1 1 1 1 SET domain Pkinase PF00069.20 ESL10685.1 - 3.5e-29 101.7 0.0 5.4e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10685.1 - 6.7e-22 77.8 0.0 9.2e-22 77.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL10685.1 - 0.00052 19.8 0.1 0.0026 17.5 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Septum_form PF13845.1 ESL10685.1 - 0.083 12.3 0.0 0.58 9.6 0.0 2.0 2 0 0 2 2 2 0 Septum formation PPR_2 PF13041.1 ESL10686.1 - 2.8e-06 27.1 0.0 0.0075 16.2 0.0 2.4 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.1 ESL10686.1 - 0.0029 17.7 1.4 0.019 15.2 0.1 3.0 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR PF01535.15 ESL10686.1 - 0.0051 16.7 0.1 0.017 15.0 0.0 2.0 1 0 0 1 1 1 1 PPR repeat PPR_1 PF12854.2 ESL10686.1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 PPR repeat Rep_fac_C PF08542.6 ESL10687.1 - 1.1e-18 66.9 0.0 2.6e-18 65.7 0.0 1.6 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESL10687.1 - 1.3e-14 54.2 0.0 1.9e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 ESL10687.1 - 1.6e-09 38.0 0.0 1.9e-08 34.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ESL10687.1 - 6.9e-05 22.9 0.1 0.046 13.7 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.9 ESL10687.1 - 0.00027 20.6 0.2 0.0051 16.5 0.1 2.8 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) Rad17 PF03215.10 ESL10687.1 - 0.0012 17.5 0.0 0.0019 16.9 0.0 1.4 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 ESL10687.1 - 0.0032 16.5 0.9 0.46 9.4 0.0 3.0 3 1 1 4 4 4 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL10687.1 - 0.0047 16.9 0.1 0.067 13.1 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.8 ESL10687.1 - 0.0055 15.4 0.0 1.6 7.3 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus Sigma54_activat PF00158.21 ESL10687.1 - 0.0086 15.5 0.0 0.87 9.0 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_14 PF13173.1 ESL10687.1 - 0.0092 15.8 0.0 18 5.2 0.0 3.6 2 1 1 3 3 3 0 AAA domain AAA_22 PF13401.1 ESL10687.1 - 0.013 15.6 0.4 0.23 11.6 0.1 2.7 1 1 1 2 2 2 0 AAA domain AAA_11 PF13086.1 ESL10687.1 - 0.041 13.4 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESL10687.1 - 0.046 13.3 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESL10687.1 - 0.061 12.4 0.1 0.47 9.5 0.1 2.2 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Syja_N PF02383.13 ESL10688.1 - 6.5e-42 143.4 0.0 9e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain DUF2417 PF10329.4 ESL10688.1 - 0.04 13.3 0.9 0.083 12.2 0.6 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Pkinase PF00069.20 ESL10689.1 - 1.4e-08 34.2 0.0 2e-07 30.4 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10689.1 - 0.016 14.2 0.0 0.028 13.5 0.0 1.5 1 1 0 1 1 1 0 Protein tyrosine kinase Kelch_5 PF13854.1 ESL10691.1 - 9.1e-20 70.1 6.9 8.6e-06 25.5 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESL10691.1 - 7e-16 57.9 12.6 0.0026 17.8 0.1 7.4 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESL10691.1 - 1.9e-15 56.3 15.6 0.00022 20.8 0.1 7.1 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESL10691.1 - 1.4e-13 50.3 4.8 0.02 15.0 0.0 5.8 5 1 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESL10691.1 - 6.9e-13 47.9 1.8 0.0013 18.1 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESL10691.1 - 1.6e-08 33.9 6.2 0.022 14.4 0.1 5.5 6 0 0 6 6 6 2 Kelch motif Ribosomal_L18p PF00861.17 ESL10692.1 - 4e-38 130.2 0.3 4e-38 130.2 0.2 1.7 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 ESL10692.1 - 3.1e-24 85.3 6.8 3.1e-24 85.3 4.7 1.6 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Helicase_C PF00271.26 ESL10693.1 - 2.8e-11 43.1 0.2 8.3e-11 41.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.18 ESL10693.1 - 1.1e-10 41.4 0.0 2.1e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESL10693.1 - 6.9e-06 25.8 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold FERM_N PF09379.5 ESL10693.1 - 0.096 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 FERM N-terminal domain Fer2 PF00111.22 ESL10694.1 - 9.8e-13 47.6 0.9 1.5e-12 47.0 0.6 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain p450 PF00067.17 ESL10695.1 - 8e-51 172.9 0.1 1.2e-50 172.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Lipase_3 PF01764.20 ESL10696.1 - 4.4e-18 65.2 0.0 9.2e-18 64.2 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 ESL10696.1 - 1e-06 28.5 0.0 1.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 ESL10696.1 - 2.5e-05 24.2 0.7 2.5e-05 24.2 0.5 1.7 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL10696.1 - 0.00052 19.7 0.0 0.00092 18.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL10696.1 - 0.0025 17.4 0.0 0.0046 16.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 ESL10696.1 - 0.045 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.3 ESL10696.1 - 0.055 12.8 0.0 0.087 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase PF00151.14 ESL10696.1 - 0.16 11.1 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Lipase DEAD PF00270.24 ESL10697.1 - 5.9e-08 32.3 0.0 1.3e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL10697.1 - 6.1e-08 32.4 0.0 1.5e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 ESL10697.1 - 1.4e-05 24.9 0.8 8.1e-05 22.5 0.0 2.8 3 1 0 3 3 3 1 Helicase associated domain (HA2) AAA_22 PF13401.1 ESL10697.1 - 0.00048 20.2 0.4 0.043 13.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESL10697.1 - 0.0074 15.2 0.2 0.024 13.5 0.1 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.1 ESL10697.1 - 0.15 11.5 0.0 0.36 10.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4272 PF14094.1 ESL10698.1 - 0.047 12.6 0.0 0.088 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) DUF3302 PF11742.3 ESL10698.1 - 0.1 12.4 0.4 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) PhyH PF05721.8 ESL10699.1 - 1.2e-37 129.9 0.0 1.7e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) NifU_N PF01592.11 ESL10700.1 - 1.2e-46 157.7 0.0 1.7e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain RelB PF04221.7 ESL10700.1 - 0.0054 16.4 0.1 0.0087 15.7 0.1 1.3 1 0 0 1 1 1 1 RelB antitoxin CO_deh_flav_C PF03450.12 ESL10700.1 - 0.049 13.5 0.1 0.14 12.1 0.0 1.7 1 1 1 2 2 2 0 CO dehydrogenase flavoprotein C-terminal domain Nop PF01798.13 ESL10702.1 - 4.4e-57 191.5 0.1 6e-57 191.1 0.1 1.2 1 0 0 1 1 1 1 Putative snoRNA binding domain NYD-SP28_assoc PF14775.1 ESL10702.1 - 0.0084 15.7 0.3 0.025 14.2 0.0 1.9 2 0 0 2 2 2 1 Sperm tail C-terminal domain MSP1_C PF07462.6 ESL10702.1 - 0.012 13.9 0.1 0.016 13.6 0.1 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus CBFB_NFYA PF02045.10 ESL10702.1 - 0.91 10.1 4.2 0.3 11.6 0.4 2.0 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B NAC PF01849.13 ESL10703.1 - 2.6e-19 68.5 0.0 3.5e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 NAC domain Arginosuc_synth PF00764.14 ESL10704.1 - 1.5e-13 50.5 0.0 2.7e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Arginosuccinate synthase MGS PF02142.17 ESL10704.1 - 8.2e-10 38.4 0.0 2.5e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain CPSase_L_D2 PF02786.12 ESL10704.1 - 6.2e-06 25.6 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.1 ESL10704.1 - 1.5e-05 23.9 0.0 2.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 ESL10704.1 - 0.011 15.4 0.0 0.032 13.9 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain LRR_6 PF13516.1 ESL10705.1 - 3.4e-42 137.7 50.3 0.013 15.5 0.0 19.0 17 2 1 18 18 18 15 Leucine Rich repeat LRR_4 PF12799.2 ESL10705.1 - 4.4e-16 58.0 35.5 0.012 15.2 0.0 11.4 9 3 4 13 13 13 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL10705.1 - 9.4e-08 31.0 33.5 11 6.5 0.0 15.8 17 2 0 17 17 17 1 Leucine Rich Repeat LRR_8 PF13855.1 ESL10705.1 - 0.0025 17.5 34.7 1.2 8.9 0.4 10.1 9 2 0 10 10 10 3 Leucine rich repeat LRR_7 PF13504.1 ESL10705.1 - 0.012 15.7 17.0 31 5.3 0.0 10.4 13 0 0 13 13 13 0 Leucine rich repeat Abhydrolase_5 PF12695.2 ESL10705.1 - 0.037 13.7 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family XPC-binding PF09280.6 ESL10705.1 - 0.057 12.8 0.2 13 5.3 0.0 3.6 3 0 0 3 3 3 0 XPC-binding domain TFIIB PF00382.14 ESL10706.1 - 3.3e-23 81.2 0.1 5.2e-11 42.1 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 ESL10706.1 - 0.033 13.5 0.0 0.073 12.4 0.0 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding DUF998 PF06197.8 ESL10706.1 - 0.041 13.2 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF998) DUF4557 PF15101.1 ESL10707.1 - 0.047 13.5 2.1 0.053 13.3 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) BNIP3 PF06553.7 ESL10707.1 - 0.091 12.1 3.4 0.11 11.8 2.4 1.1 1 0 0 1 1 1 0 BNIP3 DUF4407 PF14362.1 ESL10707.1 - 1.3 7.9 4.9 1.8 7.4 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TraW_N PF12477.3 ESL10708.1 - 0.13 12.1 0.6 0.21 11.5 0.4 1.3 1 0 0 1 1 1 0 Sex factor F TraW protein N terminal GTP_EFTU PF00009.22 ESL10709.1 - 1.4e-46 158.3 0.0 2.2e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 ESL10709.1 - 1.3e-16 60.1 0.0 3.5e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 ESL10709.1 - 1.4e-07 31.5 0.1 2.7e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.13 ESL10709.1 - 8.9e-07 28.5 0.0 2.5e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 ESL10709.1 - 5.1e-05 23.0 0.0 0.00025 20.8 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II Miro PF08477.8 ESL10709.1 - 0.017 15.6 0.0 0.036 14.5 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein M_domain PF12938.2 ESL10711.1 - 0.16 11.7 0.1 1.4 8.7 0.0 1.9 2 0 0 2 2 2 0 M domain of GW182 FAD_binding_3 PF01494.14 ESL10713.1 - 2.2e-10 40.1 0.0 0.00036 19.7 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 ESL10713.1 - 3.7e-07 30.0 0.0 1e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESL10713.1 - 2.7e-05 23.2 0.1 0.00096 18.1 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESL10713.1 - 3.2e-05 24.2 0.0 8.9e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESL10713.1 - 0.00033 19.6 0.1 0.001 18.0 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 ESL10713.1 - 0.0025 17.7 0.0 0.0045 16.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESL10713.1 - 0.015 15.1 0.0 0.45 10.2 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.12 ESL10713.1 - 0.02 13.9 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 ESL10713.1 - 0.045 13.8 0.0 0.4 10.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESL10713.1 - 0.045 12.6 0.0 0.15 10.9 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein K_oxygenase PF13434.1 ESL10713.1 - 0.084 11.7 0.1 0.84 8.4 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Lyase_aromatic PF00221.14 ESL10714.1 - 6.4e-182 605.2 0.1 7.4e-182 605.0 0.1 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase Endonuclease_NS PF01223.18 ESL10715.1 - 7.7e-21 74.6 0.1 1.6e-20 73.6 0.1 1.6 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease DUF2205 PF10224.4 ESL10716.1 - 4.3 6.9 16.4 0.18 11.4 2.6 3.5 2 1 1 3 3 3 0 Predicted coiled-coil protein (DUF2205) TPR_12 PF13424.1 ESL10717.1 - 4.4e-11 42.5 0.8 0.00097 19.0 0.0 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10717.1 - 1.7e-08 33.9 0.0 0.00021 20.8 0.0 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESL10717.1 - 1.7e-08 33.7 2.2 0.067 13.1 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10717.1 - 2.8e-07 30.7 0.0 0.0012 19.0 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL10717.1 - 9.2e-07 29.3 0.1 0.00014 22.3 0.0 3.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10717.1 - 1.4e-06 28.4 0.0 0.15 12.7 0.0 4.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10717.1 - 1.7e-06 28.0 0.0 0.0024 18.2 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL10717.1 - 9.3e-06 25.7 0.1 4.8e-05 23.3 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESL10717.1 - 0.0051 16.4 2.0 21 5.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL10717.1 - 0.0061 16.2 5.0 7 6.7 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL10717.1 - 0.0063 16.0 0.6 0.93 9.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat PPR PF01535.15 ESL10717.1 - 0.0085 16.0 0.4 0.74 9.9 0.0 3.2 3 0 0 3 3 3 1 PPR repeat TPR_10 PF13374.1 ESL10717.1 - 0.0099 15.7 0.7 12 6.0 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.1 ESL10717.1 - 0.035 13.2 0.3 0.81 8.7 0.0 2.4 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP P5CR_dimer PF14748.1 ESL10718.1 - 4.2e-41 139.2 4.1 7e-41 138.5 2.9 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 ESL10718.1 - 4.3e-17 62.3 0.1 1.1e-16 61.0 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 ESL10718.1 - 2.2e-07 30.8 0.3 3.6e-07 30.1 0.2 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 ESL10718.1 - 1.4e-06 28.4 0.1 9.9e-06 25.6 0.1 2.3 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.11 ESL10718.1 - 0.0012 18.2 0.1 0.0033 16.8 0.1 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.17 ESL10718.1 - 0.0019 18.7 0.1 0.0062 17.0 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_Gly3P_dh_N PF01210.18 ESL10718.1 - 0.0026 17.5 0.8 0.0099 15.6 0.6 1.9 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MPC PF03650.8 ESL10719.1 - 2.7e-07 30.5 0.2 3.5e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) RNase_H2_suC PF08615.6 ESL10720.1 - 1.6e-14 53.8 0.0 1.9e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) YopE_N PF09020.5 ESL10720.1 - 0.11 12.5 0.2 0.75 9.8 0.0 1.9 1 1 1 2 2 2 0 YopE, N terminal Mcp5_PH PF12814.2 ESL10721.1 - 1.5e-18 66.9 0.1 2.4e-18 66.2 0.1 1.3 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology ATP-synt_DE_N PF02823.11 ESL10722.1 - 1e-15 57.2 0.0 1.6e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain NAD_binding_9 PF13454.1 ESL10724.1 - 0.018 14.8 0.4 0.031 14.0 0.3 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Kinetocho_Slk19 PF12709.2 ESL10724.1 - 3.3 7.8 10.1 0.35 10.9 2.3 2.4 2 0 0 2 2 2 0 Central kinetochore-associated Mt_ATP-synt_B PF05405.9 ESL10724.1 - 5.8 6.3 9.4 3.2 7.1 5.2 1.5 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Enkurin PF13864.1 ESL10724.1 - 6 7.1 12.6 1.3 9.3 1.7 2.3 2 0 0 2 2 2 0 Calmodulin-binding APC10 PF03256.11 ESL10725.1 - 1.2e-47 162.0 0.0 2.4e-47 161.0 0.0 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.20 ESL10725.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 F5/8 type C domain UVR PF02151.14 ESL10726.1 - 0.00036 19.9 0.8 0.00036 19.9 0.6 2.5 2 0 0 2 2 2 1 UvrB/uvrC motif Fe-ADH PF00465.14 ESL10727.1 - 0.0025 16.5 1.3 0.0042 15.7 0.9 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase FBP PF07299.6 ESL10727.1 - 0.0097 15.2 1.9 0.0097 15.2 1.3 1.6 1 1 1 2 2 2 1 Fibronectin-binding protein (FBP) AAA_23 PF13476.1 ESL10727.1 - 0.43 10.8 12.2 0.66 10.2 8.4 1.3 1 0 0 1 1 1 0 AAA domain APG6 PF04111.7 ESL10727.1 - 1.4 7.9 25.0 0.097 11.7 10.0 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF3552 PF12072.3 ESL10727.1 - 1.4 8.1 30.3 1.1 8.4 4.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Prominin PF05478.6 ESL10727.1 - 2.8 5.3 7.8 3.2 5.1 5.1 1.3 1 1 0 1 1 1 0 Prominin V_ATPase_I PF01496.14 ESL10727.1 - 6.4 4.5 15.3 2.2 6.0 8.3 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Reo_sigmaC PF04582.7 ESL10727.1 - 8.5 5.4 6.6 14 4.7 0.5 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein NatB_MDM20 PF09797.4 ESL10728.1 - 1.2e-68 231.4 0.0 2e-68 230.8 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.1 ESL10728.1 - 1.1e-05 25.6 10.9 3.9e-05 23.9 2.6 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.3 ESL10728.1 - 0.0058 15.4 2.3 0.28 9.8 0.5 2.4 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_14 PF13428.1 ESL10728.1 - 0.023 15.2 0.2 0.023 15.2 0.2 6.2 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10728.1 - 0.34 10.6 8.5 0.16 11.6 0.6 3.4 3 0 0 3 3 3 0 TPR repeat TPR_16 PF13432.1 ESL10728.1 - 1 10.0 9.6 0.081 13.6 0.9 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10729.1 - 0.00022 21.5 1.4 0.13 12.6 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL10729.1 - 0.0059 17.2 0.3 2.5 8.8 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL10729.1 - 0.025 14.4 0.1 0.078 12.8 0.1 1.8 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 ESL10729.1 - 0.047 13.4 1.7 0.15 11.9 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat L27 PF02828.11 ESL10729.1 - 0.077 12.6 0.0 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 L27 domain TPR_14 PF13428.1 ESL10729.1 - 0.16 12.6 0.4 58 4.7 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESL10729.1 - 0.32 11.2 2.9 4.7 7.6 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat NTP_transf_3 PF12804.2 ESL10730.1 - 0.0004 20.4 0.0 0.00095 19.2 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 ESL10730.1 - 0.0017 17.7 0.0 0.003 16.8 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 ESL10730.1 - 0.0064 15.9 15.5 0.012 15.1 1.2 3.8 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) WW PF00397.21 ESL10733.1 - 0.0061 16.3 1.6 0.018 14.8 1.1 1.9 1 0 0 1 1 1 1 WW domain Troponin PF00992.15 ESL10734.1 - 0.038 14.0 0.9 0.038 14.0 0.6 2.0 2 0 0 2 2 2 0 Troponin DUF4404 PF14357.1 ESL10734.1 - 0.073 13.4 5.4 0.069 13.5 2.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF2094 PF09867.4 ESL10734.1 - 0.096 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2094) HALZ PF02183.13 ESL10734.1 - 0.1 12.3 1.7 3.4 7.4 0.2 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper BT1 PF03092.11 ESL10735.1 - 2.5e-152 507.5 9.0 3e-152 507.3 6.2 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 ESL10735.1 - 0.02 13.6 0.5 0.02 13.6 0.3 4.8 1 1 4 5 5 5 0 Major Facilitator Superfamily P21-Arc PF04062.9 ESL10736.1 - 4.4e-37 127.5 0.0 4.7e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hid1 PF12722.2 ESL10737.1 - 1.3e-35 122.4 0.4 1.9e-34 118.6 0.1 2.5 2 1 0 2 2 2 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 ESL10737.1 - 3.9e-28 97.9 0.3 1.8e-20 72.6 0.3 2.3 2 1 0 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Proteasome PF00227.21 ESL10738.1 - 4.5e-46 156.5 0.1 5.3e-46 156.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESL10738.1 - 6e-11 41.4 1.3 6.2e-11 41.4 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature IQ PF00612.22 ESL10739.1 - 0.28 10.9 4.3 1 9.1 0.3 3.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif Ax_dynein_light PF10211.4 ESL10741.1 - 1.1e-55 188.4 4.1 1.3e-55 188.2 2.8 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain HAP1_N PF04849.8 ESL10741.1 - 0.027 13.4 4.0 0.039 12.8 2.7 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ORF6C PF10552.4 ESL10741.1 - 0.12 12.0 0.7 0.22 11.2 0.5 1.4 1 0 0 1 1 1 0 ORF6C domain Fmp27_WPPW PF10359.4 ESL10741.1 - 0.16 10.3 1.9 0.22 9.9 1.3 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain EF-hand_7 PF13499.1 ESL10742.1 - 2.6e-10 40.2 0.1 4.5e-06 26.7 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL10742.1 - 8.2e-08 31.7 0.1 0.00073 19.0 0.0 3.3 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL10742.1 - 1.1e-07 31.1 0.3 0.012 15.3 0.0 3.8 3 1 0 3 3 3 2 EF-hand domain EF-hand_9 PF14658.1 ESL10742.1 - 7.2e-07 29.0 0.0 0.013 15.3 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 ESL10742.1 - 2.6e-05 23.1 0.1 0.13 11.6 0.0 3.8 4 0 0 4 4 4 2 EF hand DUF2087 PF09860.4 ESL10742.1 - 0.0009 18.9 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2087) OST-HTH PF12872.2 ESL10742.1 - 0.032 14.0 0.1 0.71 9.7 0.0 2.7 1 1 1 2 2 2 0 OST-HTH/LOTUS domain RNA_pol_Rpb4 PF03874.11 ESL10742.1 - 0.033 14.1 0.1 6.5 6.7 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb4 DUF3349 PF11829.3 ESL10742.1 - 0.058 13.8 0.5 0.47 10.9 0.1 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) ERAP1_C PF11838.3 ESL10742.1 - 0.092 11.9 0.0 1.9 7.6 0.0 2.3 1 1 2 3 3 3 0 ERAP1-like C-terminal domain Toprim_Crpt PF13342.1 ESL10742.1 - 0.14 11.7 0.1 3.8 7.2 0.1 2.4 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase RasGAP_C PF03836.10 ESL10743.1 - 0.097 12.3 0.6 0.16 11.6 0.4 1.3 1 0 0 1 1 1 0 RasGAP C-terminus CtIP_N PF10482.4 ESL10743.1 - 0.29 10.9 3.7 0.12 12.1 0.6 1.7 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain AA_permease_2 PF13520.1 ESL10745.1 - 6.8e-32 110.5 39.7 8.7e-32 110.1 27.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESL10745.1 - 4e-11 41.9 32.1 6.8e-11 41.1 22.2 1.4 1 0 0 1 1 1 1 Amino acid permease DUF4471 PF14740.1 ESL10748.1 - 1.8e-62 211.2 1.6 1.8e-62 211.2 1.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4471) DUF4470 PF14737.1 ESL10748.1 - 6.5e-23 80.3 0.1 2.5e-22 78.4 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4470) Peptidase_M76 PF09768.4 ESL10748.1 - 0.092 12.2 0.4 13 5.2 0.1 2.3 2 0 0 2 2 2 0 Peptidase M76 family Methyltransf_15 PF09445.5 ESL10749.1 - 1.3e-33 115.8 0.0 1.8e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 ESL10749.1 - 1.1e-13 51.2 0.0 1.5e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 ESL10749.1 - 2.7e-12 46.6 0.0 3.8e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.1 ESL10749.1 - 8.4e-11 41.6 0.0 1.1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL10749.1 - 3.3e-09 37.0 0.1 8.4e-09 35.7 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL10749.1 - 1.8e-08 34.9 0.0 2.8e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL10749.1 - 1.9e-07 30.5 0.0 2.9e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.11 ESL10749.1 - 2.5e-05 23.9 0.0 2.7e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.10 ESL10749.1 - 9.4e-05 21.8 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.8 ESL10749.1 - 0.00012 21.3 0.0 0.00016 20.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) tRNA_U5-meth_tr PF05958.6 ESL10749.1 - 0.001 17.8 0.0 0.0015 17.3 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase PCMT PF01135.14 ESL10749.1 - 0.0013 18.3 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.7 ESL10749.1 - 0.0014 19.0 0.1 0.0026 18.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.14 ESL10749.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family TehB PF03848.9 ESL10749.1 - 0.014 14.5 0.1 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB RrnaAD PF00398.15 ESL10749.1 - 0.026 13.5 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_3 PF01596.12 ESL10749.1 - 0.066 12.2 0.0 0.094 11.7 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_12 PF08242.7 ESL10749.1 - 0.071 13.5 0.0 0.17 12.3 0.0 1.6 2 0 0 2 2 1 0 Methyltransferase domain CMAS PF02353.15 ESL10749.1 - 0.08 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DNA_methylase PF00145.12 ESL10749.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Nol1_Nop2_Fmu PF01189.12 ESL10749.1 - 0.12 11.6 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 NOL1/NOP2/sun family Pox_MCEL PF03291.11 ESL10749.1 - 0.13 11.0 0.1 0.18 10.6 0.1 1.1 1 0 0 1 1 1 0 mRNA capping enzyme NAD_kinase PF01513.16 ESL10750.1 - 6e-17 61.3 0.0 9.9e-17 60.6 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 ESL10750.1 - 0.096 12.1 0.0 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF3808 PF10300.4 ESL10751.1 - 2.8e-58 197.6 0.0 4.2e-58 197.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) SCO1-SenC PF02630.9 ESL10753.1 - 1.4e-28 99.7 0.0 1.8e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC ATP-synt_C PF00137.16 ESL10754.1 - 2.2e-17 62.6 12.0 3e-17 62.2 8.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit C zf-Di19 PF05605.7 ESL10755.1 - 0.0018 18.3 2.1 0.82 9.8 0.0 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESL10755.1 - 0.0021 18.2 9.9 0.0057 16.9 0.4 2.9 3 0 0 3 3 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESL10755.1 - 0.003 17.3 0.4 0.003 17.3 0.3 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESL10755.1 - 0.0036 17.5 6.0 0.93 9.9 0.6 2.7 2 0 0 2 2 2 2 Zinc-finger double domain FYVE PF01363.16 ESL10755.1 - 0.004 17.0 0.4 0.42 10.5 0.0 2.6 2 0 0 2 2 2 1 FYVE zinc finger zf-C2H2_4 PF13894.1 ESL10755.1 - 0.0099 16.1 3.3 0.13 12.6 0.1 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger CpXC PF14353.1 ESL10755.1 - 0.016 15.1 0.3 2 8.3 0.0 2.4 2 0 0 2 2 2 0 CpXC protein Prok-RING_1 PF14446.1 ESL10755.1 - 0.048 13.3 0.6 9.6 6.0 0.0 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zinc-ribbons_6 PF07191.7 ESL10755.1 - 0.076 12.8 2.5 0.41 10.4 0.4 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-C2H2_jaz PF12171.3 ESL10755.1 - 0.18 11.9 3.1 7 6.9 0.0 2.7 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 ESL10755.1 - 8.5 6.5 9.4 5 7.2 0.1 2.8 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) TPR_11 PF13414.1 ESL10756.1 - 1.5e-39 133.4 3.8 7.4e-09 35.1 1.0 6.1 4 2 2 6 6 6 6 TPR repeat TPR_1 PF00515.23 ESL10756.1 - 7.9e-35 117.0 0.5 0.00022 20.6 0.0 8.3 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10756.1 - 2e-32 108.4 4.2 0.006 16.4 0.1 9.9 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_12 PF13424.1 ESL10756.1 - 4.9e-26 90.4 12.5 5.3e-07 29.4 0.0 6.7 1 1 9 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.1 ESL10756.1 - 1.7e-21 74.3 0.0 0.0088 15.7 0.0 8.4 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESL10756.1 - 1e-19 70.6 6.5 8.6e-05 23.1 0.0 7.0 5 2 3 8 8 8 4 Tetratricopeptide repeat Apc3 PF12895.2 ESL10756.1 - 8.8e-17 61.0 8.1 3.9e-05 23.7 0.0 5.5 4 2 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESL10756.1 - 2.2e-16 59.4 2.9 0.00087 19.1 0.0 5.8 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10756.1 - 1.8e-15 56.0 6.7 0.0011 19.4 0.0 9.2 4 3 7 11 11 11 4 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10756.1 - 2.7e-15 55.6 4.7 0.0038 17.5 0.0 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10756.1 - 6.1e-14 52.1 8.5 8.4e-05 22.8 0.0 6.2 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESL10756.1 - 7.2e-12 44.5 6.5 0.016 15.3 0.0 8.5 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL10756.1 - 9.7e-12 43.7 0.0 0.82 9.6 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESL10756.1 - 5.1e-06 25.7 0.6 0.015 14.4 0.0 3.6 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL10756.1 - 9.5e-06 25.3 11.6 0.64 10.0 0.1 8.4 9 0 0 9 9 9 1 Tetratricopeptide repeat BTAD PF03704.12 ESL10756.1 - 0.14 12.4 6.4 0.17 12.2 0.1 3.1 2 1 1 3 3 3 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.1 ESL10756.1 - 0.53 10.2 4.1 1.8 8.4 0.0 3.3 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat CagZ PF09053.5 ESL10757.1 - 0.098 11.9 0.0 0.31 10.3 0.0 1.7 2 0 0 2 2 2 0 CagZ Ecotin PF03974.8 ESL10758.1 - 1.3e-29 102.4 0.0 1.7e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 Ecotin WD40 PF00400.27 ESL10759.1 - 7e-15 54.2 3.0 0.0084 15.9 0.2 8.9 10 0 0 10 10 10 3 WD domain, G-beta repeat PQQ_3 PF13570.1 ESL10759.1 - 0.058 13.6 0.0 1.2 9.5 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain CHASE3 PF05227.8 ESL10760.1 - 0.077 12.6 0.5 0.16 11.6 0.4 1.5 1 0 0 1 1 1 0 CHASE3 domain DCP1 PF06058.8 ESL10760.1 - 0.079 13.0 0.1 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Dcp1-like decapping family tRNA-synt_1c_C PF03950.13 ESL10761.1 - 3.8e-18 65.7 0.1 4.9e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain RHSP PF07999.6 ESL10762.1 - 3.2e-13 49.0 0.1 4.9e-13 48.4 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DNA_topoisoIV PF00521.15 ESL10763.1 - 5.4e-127 424.1 0.2 1.1e-126 423.1 0.0 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 ESL10763.1 - 5.8e-29 100.5 0.0 1.5e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 ESL10763.1 - 3.3e-10 39.6 0.0 7.3e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.17 ESL10763.1 - 3.6e-09 36.4 0.0 1.3e-08 34.7 0.0 2.0 1 0 0 1 1 1 1 Toprim domain Cut8_N PF14482.1 ESL10763.1 - 4 7.5 11.9 1.1 9.3 0.6 2.9 2 0 0 2 2 2 0 Cut8 proteasome-binding domain PBP1_TM PF14812.1 ESL10763.1 - 5 7.4 17.7 7 7.0 3.3 3.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal V-SNARE_C PF12352.3 ESL10764.1 - 0.00011 22.1 10.7 0.00021 21.2 0.2 3.6 3 1 1 4 4 4 2 Snare region anchored in the vesicle membrane C-terminus FlgN PF05130.7 ESL10764.1 - 0.034 14.3 4.7 0.052 13.8 2.3 1.9 1 1 1 2 2 2 0 FlgN protein Nsp1_C PF05064.8 ESL10764.1 - 0.1 12.2 4.7 3.3 7.3 0.2 3.0 3 0 0 3 3 3 0 Nsp1-like C-terminal region EMP24_GP25L PF01105.19 ESL10764.1 - 0.14 11.8 1.6 1.2 8.7 0.2 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Acyl-CoA_dh_C PF12806.2 ESL10764.1 - 0.18 11.6 2.1 0.37 10.6 0.7 2.0 2 0 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like TMF_DNA_bd PF12329.3 ESL10764.1 - 0.21 11.4 1.9 4.8 7.0 0.0 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding V-SNARE PF05008.10 ESL10764.1 - 1.4 9.0 4.6 0.33 11.1 0.1 2.2 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Latarcin PF10279.4 ESL10764.1 - 3.5 7.8 5.8 0.54 10.4 0.3 2.2 2 1 0 2 2 2 0 Latarcin precursor Syntaxin-6_N PF09177.6 ESL10764.1 - 8.5 6.8 7.0 7.6 7.0 0.5 3.1 1 1 1 3 3 3 0 Syntaxin 6, N-terminal PAP2 PF01569.16 ESL10765.1 - 1.5e-17 63.4 2.1 1.5e-17 63.4 1.4 1.7 2 0 0 2 2 2 1 PAP2 superfamily DUF4131 PF13567.1 ESL10765.1 - 9 5.6 8.0 1.3 8.4 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Nop PF01798.13 ESL10770.1 - 4.7e-21 74.6 0.1 1.3e-20 73.2 0.0 1.7 2 0 0 2 2 2 1 Putative snoRNA binding domain NOSIC PF08060.8 ESL10770.1 - 1.9e-11 43.6 0.0 4.1e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain zf-RING_2 PF13639.1 ESL10771.1 - 0.005 16.6 8.0 0.0094 15.7 5.3 1.8 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESL10771.1 - 0.019 15.0 5.4 0.037 14.1 3.7 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger RINGv PF12906.2 ESL10771.1 - 0.057 13.4 3.7 0.13 12.3 2.5 1.7 1 1 0 1 1 1 0 RING-variant domain UQ_con PF00179.21 ESL10771.1 - 0.057 12.8 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme zf-C3HC4 PF00097.20 ESL10771.1 - 0.07 12.8 5.3 0.27 10.9 3.5 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESL10771.1 - 0.12 12.0 6.3 0.72 9.5 4.6 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 ESL10771.1 - 0.14 12.1 7.7 0.068 13.1 3.4 2.0 2 1 0 2 2 2 0 FANCL C-terminal domain RecR PF02132.10 ESL10771.1 - 1.4 8.4 5.6 12 5.4 0.0 3.2 3 0 0 3 3 3 0 RecR protein zf-RING_4 PF14570.1 ESL10771.1 - 1.8 8.2 4.5 5.6 6.6 3.1 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RRN7 PF11781.3 ESL10771.1 - 6.2 6.4 6.1 2.5 7.6 0.0 3.1 4 0 0 4 4 4 0 RNA polymerase I-specific transcription initiation factor Rrn7 Epimerase PF01370.16 ESL10772.1 - 2.9e-35 121.7 0.0 3.9e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 ESL10772.1 - 2.5e-06 26.6 0.0 0.00044 19.2 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 ESL10772.1 - 4.3e-05 22.3 0.0 5.4e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 ESL10772.1 - 0.0013 18.6 0.0 0.0028 17.5 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 ESL10772.1 - 0.016 14.1 0.0 3.1 6.6 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESL10772.1 - 0.071 11.9 0.0 0.64 8.8 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RRM_1 PF00076.17 ESL10774.1 - 6.3e-12 44.9 0.0 1.1e-08 34.5 0.0 2.9 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL10774.1 - 2.5e-10 40.1 0.0 3.7e-07 30.0 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL10774.1 - 0.013 15.2 0.0 0.094 12.5 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ubiquitin_2 PF14560.1 ESL10776.1 - 4e-10 39.8 0.0 9.6e-10 38.5 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_8 PF13855.1 ESL10776.1 - 2.3e-07 30.4 4.0 0.022 14.5 0.4 3.9 3 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.2 ESL10776.1 - 4.7e-07 29.2 9.8 0.044 13.4 0.5 4.2 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL10776.1 - 0.00044 20.0 1.5 40 4.7 0.0 5.0 4 0 0 4 4 4 0 Leucine Rich repeat ubiquitin PF00240.18 ESL10776.1 - 0.00052 19.3 0.0 0.0024 17.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family LRR_9 PF14580.1 ESL10776.1 - 0.0047 16.5 0.6 5.9 6.4 0.0 3.4 3 0 0 3 3 3 1 Leucine-rich repeat LRR_7 PF13504.1 ESL10776.1 - 0.035 14.2 7.3 74 4.2 0.0 5.8 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.28 ESL10776.1 - 1.4 9.2 11.1 62 4.2 0.0 6.1 7 1 1 8 8 8 0 Leucine Rich Repeat DUF1042 PF06294.6 ESL10777.1 - 2e-14 53.4 0.0 3.8e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 ESL10777.1 - 2.6e-05 23.7 0.0 5.5e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain LRS4 PF10422.4 ESL10779.1 - 0.017 14.4 1.4 0.019 14.3 0.9 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DHBP_synthase PF00926.14 ESL10779.1 - 0.057 12.6 1.7 0.55 9.4 0.0 2.1 1 1 1 2 2 2 0 3,4-dihydroxy-2-butanone 4-phosphate synthase CDRT4 PF15213.1 ESL10779.1 - 0.084 12.9 0.6 0.12 12.4 0.4 1.2 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein FadA PF09403.5 ESL10779.1 - 0.49 10.4 8.2 0.14 12.1 3.0 1.9 2 0 0 2 2 2 0 Adhesion protein FadA Radial_spoke_3 PF06098.6 ESL10779.1 - 2.1 7.2 10.7 0.08 11.9 3.4 1.5 2 0 0 2 2 2 0 Radial spoke protein 3 IncA PF04156.9 ESL10779.1 - 4.6 6.7 7.6 1.3 8.5 2.8 1.8 2 0 0 2 2 2 0 IncA protein FtsJ PF01728.14 ESL10780.1 - 2.5e-25 89.4 0.0 9.8e-25 87.5 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Cu-oxidase_2 PF07731.9 ESL10781.1 - 1.8e-15 56.6 1.3 1.8e-15 56.6 0.9 2.7 3 1 1 4 4 4 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 ESL10781.1 - 6.9e-11 41.9 4.1 2.4e-07 30.5 0.3 4.1 3 1 0 3 3 3 2 Multicopper oxidase CoA_trans PF01144.18 ESL10782.1 - 5.9e-101 336.1 2.0 2.9e-63 212.9 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.1 ESL10782.1 - 0.0005 19.7 0.0 0.00088 18.9 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain WLM PF08325.5 ESL10783.1 - 3.7e-59 199.7 0.2 4.1e-35 121.3 0.0 2.6 2 1 0 2 2 2 2 WLM domain zf-RanBP PF00641.13 ESL10783.1 - 7.8e-09 34.4 30.0 0.0021 17.1 2.6 3.9 3 1 0 3 3 3 3 Zn-finger in Ran binding protein and others DUF45 PF01863.12 ESL10783.1 - 0.00034 20.4 11.7 0.0023 17.7 0.1 2.5 3 0 0 3 3 3 2 Protein of unknown function DUF45 zf-ribbon_3 PF13248.1 ESL10783.1 - 0.001 18.1 9.3 0.082 12.1 0.7 3.3 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESL10783.1 - 4.2 6.9 10.7 2.5 7.6 0.4 3.5 3 0 0 3 3 3 0 zinc-ribbon domain RIIa PF02197.12 ESL10784.1 - 0.00068 19.0 0.0 0.00091 18.6 0.0 1.2 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Dpy-30 PF05186.8 ESL10784.1 - 0.034 13.6 0.1 0.047 13.1 0.0 1.4 1 1 0 1 1 1 0 Dpy-30 motif Smr PF01713.16 ESL10784.1 - 0.06 13.5 0.1 0.068 13.3 0.1 1.1 1 0 0 1 1 1 0 Smr domain Raptor_N PF14538.1 ESL10785.1 - 3.8e-16 59.2 0.0 6e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain CRIC_ras_sig PF10534.4 ESL10786.1 - 0.0013 18.7 0.1 0.014 15.4 0.0 2.8 2 0 0 2 2 2 1 Connector enhancer of kinase suppressor of ras TPR_12 PF13424.1 ESL10787.1 - 0.0053 16.6 4.6 0.1 12.5 0.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10787.1 - 0.033 14.0 4.3 4 7.6 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10787.1 - 0.038 14.3 1.0 6.8 7.1 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10787.1 - 0.93 10.3 8.6 1.5 9.6 0.8 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat INCENP_N PF12178.3 ESL10788.1 - 6.7e-18 63.9 0.1 1.2e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Chromosome passenger complex (CPC) protein INCENP N terminal DUF4282 PF14110.1 ESL10789.1 - 1.7 8.8 15.7 0.11 12.7 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) DUF3040 PF11239.3 ESL10789.1 - 2.5 8.1 9.4 1.2 9.2 0.7 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) TM231 PF10149.4 ESL10789.1 - 5.3 5.9 10.1 1.6 7.6 0.5 2.2 2 0 0 2 2 2 0 Transmembrane protein 231 Cytomega_TRL10 PF06084.6 ESL10789.1 - 7.6 6.3 6.0 5.7 6.7 0.8 2.1 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein AAA_17 PF13207.1 ESL10790.1 - 3.8e-11 43.8 13.2 1.3e-08 35.6 0.0 4.9 5 1 0 5 5 5 2 AAA domain YHS PF04945.8 ESL10790.1 - 1.3e-10 40.8 0.1 0.00076 19.2 0.0 3.5 3 0 0 3 3 3 3 YHS domain ADK PF00406.17 ESL10790.1 - 3.6e-09 36.6 0.0 6.9e-07 29.2 0.0 3.1 3 0 0 3 3 3 1 Adenylate kinase SKI PF01202.17 ESL10790.1 - 0.0023 17.8 12.0 0.01 15.7 0.0 4.8 4 0 0 4 4 4 1 Shikimate kinase AAA_18 PF13238.1 ESL10790.1 - 0.0078 16.5 0.0 0.0078 16.5 0.0 5.3 7 1 0 7 7 7 1 AAA domain AAA_22 PF13401.1 ESL10790.1 - 0.013 15.6 0.2 0.24 11.5 0.0 3.3 4 0 0 4 4 4 0 AAA domain DUF3508 PF12018.3 ESL10790.1 - 0.014 14.4 0.2 0.014 14.4 0.2 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF3508) MobB PF03205.9 ESL10790.1 - 0.042 13.5 0.1 8.3 6.1 0.1 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 ESL10790.1 - 0.13 12.0 0.0 0.13 12.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA PF00004.24 ESL10790.1 - 0.37 10.9 2.0 0.39 10.9 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ANTH PF07651.11 ESL10791.1 - 5.7e-27 94.1 0.6 7.4e-27 93.7 0.4 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 ESL10791.1 - 1.2e-06 28.4 0.1 2.8e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 ENTH domain zf-RanBP PF00641.13 ESL10792.1 - 6.7e-05 21.9 2.2 0.00011 21.2 1.5 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_6 PF14259.1 ESL10792.1 - 0.0032 17.4 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PEX11 PF05648.9 ESL10793.1 - 2.1e-11 43.5 5.5 2e-09 37.0 3.8 2.8 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Trypsin PF00089.21 ESL10795.1 - 8.6e-06 25.4 0.0 1.9e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.1 ESL10795.1 - 1.5e-05 24.9 0.0 2.2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain LRR_4 PF12799.2 ESL10797.1 - 6.8e-16 57.4 3.7 0.00031 20.2 0.1 3.7 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESL10797.1 - 2e-08 33.4 3.7 0.39 10.9 0.0 6.2 5 1 1 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.28 ESL10797.1 - 4.1e-07 29.1 9.4 1.8 8.9 0.2 7.0 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_8 PF13855.1 ESL10797.1 - 4.1e-06 26.4 10.7 0.00061 19.4 1.5 3.9 2 2 2 4 4 4 3 Leucine rich repeat LRR_7 PF13504.1 ESL10797.1 - 9.5e-06 25.0 10.9 1.2 9.6 0.2 6.6 6 0 0 6 6 6 1 Leucine rich repeat LRR_9 PF14580.1 ESL10797.1 - 0.00021 20.9 0.8 0.28 10.7 0.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat UCH PF00443.24 ESL10798.1 - 8.4e-51 172.6 0.1 1.3e-50 172.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL10798.1 - 1e-22 80.9 0.0 1.5e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.1 ESL10798.1 - 6.5e-16 58.4 0.1 1.8e-13 50.3 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.3 ESL10798.1 - 2.6e-09 36.6 0.0 5.1e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 NTP_transf_2 PF01909.18 ESL10799.1 - 5.5e-05 23.4 0.2 0.00017 21.8 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain Dpy-30 PF05186.8 ESL10800.1 - 6.1e-07 28.8 0.2 0.0024 17.3 0.0 2.3 2 0 0 2 2 2 2 Dpy-30 motif AAA_33 PF13671.1 ESL10801.1 - 1.8e-06 27.8 0.1 3.6e-05 23.6 0.0 2.6 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESL10801.1 - 0.0005 19.2 0.1 0.0021 17.1 0.0 2.1 2 1 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 ESL10801.1 - 0.00075 20.3 0.0 0.0021 18.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL10801.1 - 0.0072 16.3 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain APS_kinase PF01583.15 ESL10801.1 - 0.026 14.1 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.1 ESL10801.1 - 0.21 11.9 0.5 0.72 10.1 0.3 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL10801.1 - 0.21 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase DUF3338 PF11819.3 ESL10802.1 - 0.0033 16.8 0.2 0.0074 15.7 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3338) Apolipoprotein PF01442.13 ESL10802.1 - 0.011 15.2 3.9 0.023 14.2 2.7 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain UPF0149 PF03695.8 ESL10802.1 - 0.04 13.8 0.1 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Lipoprotein_7 PF01540.11 ESL10802.1 - 0.08 12.0 0.1 0.26 10.2 0.0 1.8 2 0 0 2 2 2 0 Adhesin lipoprotein DUF1664 PF07889.7 ESL10802.1 - 0.28 10.9 2.1 0.73 9.6 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.1 ESL10802.1 - 1.4 9.2 7.4 1.2 9.4 3.7 2.0 2 0 0 2 2 2 0 Snapin/Pallidin HD PF01966.17 ESL10803.1 - 4.5e-14 52.5 0.1 9.4e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 HD domain HDOD PF08668.7 ESL10803.1 - 0.0002 20.7 0.0 0.00034 19.9 0.0 1.4 1 0 0 1 1 1 1 HDOD domain SKG6 PF08693.5 ESL10804.1 - 0.31 10.4 0.2 0.31 10.4 0.1 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Rft-1 PF04506.8 ESL10805.1 - 2.2e-33 115.4 6.1 3.4e-32 111.5 4.2 2.1 1 1 0 1 1 1 1 Rft protein L51_S25_CI-B8 PF05047.11 ESL10806.1 - 0.006 16.2 0.1 0.0094 15.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF605 PF04652.11 ESL10809.1 - 1.6e-58 198.9 3.0 8.9e-43 147.1 0.1 2.2 1 1 1 2 2 2 2 Vta1 like MatE PF01554.13 ESL10810.1 - 2.2e-34 118.4 27.4 2.7e-20 72.6 6.9 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 ESL10810.1 - 0.0014 18.4 4.2 0.0014 18.4 2.9 5.5 3 3 1 5 5 5 2 Polysaccharide biosynthesis C-terminal domain Kinesin PF00225.18 ESL10811.1 - 7.7e-68 228.6 0.0 9.9e-68 228.2 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain DUF1077 PF06417.7 ESL10812.1 - 1e-41 141.2 1.1 1.1e-41 141.0 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Plus-3 PF03126.13 ESL10813.1 - 0.038 14.0 0.2 1.6 8.8 0.0 3.4 2 2 0 2 2 2 0 Plus-3 domain DIRP PF06584.8 ESL10813.1 - 0.094 12.5 5.2 0.19 11.5 3.6 1.6 1 0 0 1 1 1 0 DIRP DUF3490 PF11995.3 ESL10813.1 - 0.13 11.7 7.0 0.24 10.9 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) DUF1289 PF06945.8 ESL10813.1 - 0.18 11.2 9.0 0.62 9.5 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) GBP_C PF02841.9 ESL10813.1 - 6.4 5.8 17.5 9.8 5.2 12.1 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain ubiquitin PF00240.18 ESL10814.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family LRR_6 PF13516.1 ESL10815.1 - 7.1e-11 41.0 6.9 0.0039 17.0 0.1 4.5 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 ESL10815.1 - 0.00092 18.7 2.7 0.1 12.2 0.1 3.3 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL10815.1 - 0.0014 18.3 1.0 27 5.3 0.0 4.6 4 0 0 4 4 4 2 Leucine Rich Repeat Kinesin PF00225.18 ESL10816.1 - 4.9e-85 285.1 0.2 1.1e-84 283.9 0.2 1.6 1 0 0 1 1 1 1 Kinesin motor domain Pkinase PF00069.20 ESL10818.1 - 5e-66 222.5 0.1 9.3e-66 221.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain POLO_box PF00659.13 ESL10818.1 - 1.9e-41 139.8 0.3 3.7e-24 84.4 0.1 2.6 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_Tyr PF07714.12 ESL10818.1 - 2.6e-35 121.7 0.0 3.7e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10818.1 - 3.1e-06 26.3 0.0 7.1e-06 25.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL10818.1 - 0.021 14.5 2.2 0.046 13.4 0.1 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESL10818.1 - 0.19 10.7 2.4 0.22 10.5 0.5 1.8 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family COG2 PF06148.6 ESL10819.1 - 2.2e-39 134.3 1.2 2.2e-39 134.3 0.8 2.6 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.3 ESL10819.1 - 2.9e-23 82.3 0.0 2.6e-22 79.2 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3510) Pex16 PF08610.5 ESL10820.1 - 3.5e-33 115.0 0.0 2.4e-31 108.9 0.0 2.1 2 0 0 2 2 2 2 Peroxisomal membrane protein (Pex16) Noc2 PF03715.8 ESL10822.1 - 2e-99 332.2 2.0 2.7e-99 331.8 1.4 1.2 1 0 0 1 1 1 1 Noc2p family Sugar_tr PF00083.19 ESL10824.1 - 1.3e-42 145.9 11.8 1.5e-42 145.7 8.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESL10824.1 - 3.2e-11 42.5 7.6 4.3e-11 42.1 5.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4149 PF13664.1 ESL10824.1 - 0.14 12.2 6.8 0.053 13.5 0.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) MFS_2 PF13347.1 ESL10824.1 - 0.35 9.2 13.4 0.68 8.2 9.3 1.5 1 1 0 1 1 1 0 MFS/sugar transport protein DUF3522 PF12036.3 ESL10824.1 - 0.9 9.3 6.0 8.7 6.0 4.2 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3522) DUF204 PF02659.10 ESL10824.1 - 1.2 9.3 14.9 0.13 12.3 0.7 3.5 3 1 0 3 3 3 0 Domain of unknown function DUF Paramecium_SA PF01508.11 ESL10824.1 - 1.6 9.0 15.4 77 3.6 10.7 2.5 1 1 0 1 1 1 0 Paramecium surface antigen domain DUF202 PF02656.10 ESL10824.1 - 3.7 7.8 8.5 4.5 7.5 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF202) PSI PF01437.20 ESL10824.1 - 6.6 6.9 15.1 4.5e+02 1.1 10.5 2.6 1 1 0 1 1 1 0 Plexin repeat His_Phos_2 PF00328.17 ESL10826.1 - 2.8e-06 26.8 0.4 7.3e-05 22.2 0.2 2.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PIF1 PF05970.9 ESL10827.1 - 1.8e-31 109.4 0.2 1.5e-27 96.4 0.0 2.8 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 ESL10827.1 - 6.1e-14 52.0 0.0 1.2e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL10827.1 - 0.00011 21.8 1.0 0.00035 20.2 0.7 1.8 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESL10827.1 - 0.0028 16.6 0.4 0.019 13.9 0.3 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 ESL10827.1 - 0.0045 17.1 0.0 0.016 15.3 0.0 2.0 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 ESL10827.1 - 0.0049 16.4 0.4 1.3 8.5 0.0 2.6 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 ESL10827.1 - 0.007 16.4 0.6 0.064 13.3 0.4 2.5 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 ESL10827.1 - 0.011 15.4 1.6 0.013 15.2 0.1 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B UvrD-helicase PF00580.16 ESL10827.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain T2SE PF00437.15 ESL10827.1 - 0.035 13.0 0.0 0.082 11.7 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF853 PF05872.7 ESL10827.1 - 0.071 11.4 0.3 0.11 10.8 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DEAD PF00270.24 ESL10827.1 - 0.087 12.3 0.1 1.7 8.1 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.1 ESL10827.1 - 0.12 11.9 0.0 14 5.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.1 ESL10827.1 - 0.13 12.2 0.5 0.53 10.2 0.1 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_10 PF12846.2 ESL10827.1 - 0.16 11.3 0.5 0.38 10.1 0.1 1.8 2 0 0 2 2 2 0 AAA-like domain AFG1_ATPase PF03969.11 ESL10829.1 - 2.1e-82 276.8 2.1 2.9e-76 256.6 0.0 3.0 2 1 1 3 3 3 2 AFG1-like ATPase Bac_DnaA PF00308.13 ESL10829.1 - 1.4e-05 24.8 0.2 0.057 13.0 0.0 2.9 3 0 0 3 3 3 2 Bacterial dnaA protein AAA_22 PF13401.1 ESL10829.1 - 0.0096 16.0 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL10829.1 - 0.02 14.8 0.0 0.07 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.7 ESL10829.1 - 0.052 13.1 0.0 0.097 12.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 ESL10829.1 - 0.064 13.4 0.0 0.2 11.8 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DnaJ PF00226.26 ESL10831.1 - 2.9e-21 74.9 0.3 4.8e-21 74.2 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain MMS1_N PF10433.4 ESL10831.1 - 0.01 13.9 0.0 0.014 13.5 0.0 1.1 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term RIO1 PF01163.17 ESL10834.1 - 1.1e-65 220.5 1.7 1.3e-65 220.2 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESL10834.1 - 0.046 13.4 2.7 0.061 13.0 0.1 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family HD_3 PF13023.1 ESL10836.1 - 8.1e-39 133.0 0.0 9.5e-39 132.7 0.0 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 ESL10836.1 - 4.8e-07 29.8 0.0 9.2e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 HD domain RNA_pol PF00940.14 ESL10837.1 - 1.2e-124 415.9 0.0 1.8e-124 415.2 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase Acetyltransf_3 PF13302.1 ESL10838.1 - 4.5e-22 78.7 0.0 5.6e-12 46.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESL10838.1 - 4.2e-07 29.9 0.0 7.6e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 ESL10838.1 - 4.8e-06 26.5 0.4 3.9e-05 23.5 0.0 2.3 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL10838.1 - 5.8e-05 22.7 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.1 ESL10838.1 - 0.00015 21.7 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain SCO1-SenC PF02630.9 ESL10839.1 - 9.2e-31 106.7 0.0 5e-29 101.1 0.0 2.2 1 1 0 1 1 1 1 SCO1/SenC Cupin_8 PF13621.1 ESL10840.1 - 2.7e-60 203.9 0.0 2.7e-59 200.7 0.0 2.0 1 1 0 1 1 1 1 Cupin-like domain DnaJ PF00226.26 ESL10841.1 - 0.0007 19.2 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain PTPA PF03095.10 ESL10842.1 - 3.4e-99 331.8 0.0 4.2e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Ribosomal_L1 PF00687.16 ESL10843.1 - 1.2e-31 109.8 1.7 1.5e-31 109.4 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PhosphMutase PF10143.4 ESL10844.1 - 1e-57 194.5 0.0 1.4e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.13 ESL10844.1 - 1.3e-23 83.6 0.0 7.2e-23 81.2 0.0 2.0 1 1 0 1 1 1 1 Metalloenzyme superfamily AIG2 PF06094.7 ESL10844.1 - 3.4e-16 59.5 0.0 7.7e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 AIG2-like family PKD_channel PF08016.7 ESL10845.1 - 3.3e-09 35.6 16.9 5.7e-09 34.9 11.7 1.4 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 ESL10845.1 - 0.036 13.3 24.9 0.018 14.3 14.0 2.2 2 0 0 2 2 2 0 Ion transport protein Fis1_TPR_C PF14853.1 ESL10846.1 - 4.6e-13 48.8 0.9 1.1e-12 47.5 0.4 1.7 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 ESL10846.1 - 0.002 17.9 0.3 0.14 12.0 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10846.1 - 0.019 14.8 0.3 0.054 13.4 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL10846.1 - 0.03 13.9 0.0 0.084 12.5 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL10846.1 - 0.04 13.5 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 TPR repeat Fis1_TPR_N PF14852.1 ESL10846.1 - 0.062 12.6 0.2 0.15 11.4 0.1 1.7 1 1 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat TPR_14 PF13428.1 ESL10846.1 - 0.066 13.8 0.1 0.18 12.4 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat VMA21 PF09446.5 ESL10846.1 - 0.23 11.4 1.0 0.4 10.6 0.7 1.3 1 0 0 1 1 1 0 VMA21-like domain Arg_repressor_C PF02863.13 ESL10847.1 - 0.091 12.2 0.0 1.4 8.3 0.0 2.7 3 0 0 3 3 3 0 Arginine repressor, C-terminal domain ERM PF00769.14 ESL10847.1 - 3.6 7.0 39.5 0.32 10.5 8.3 3.5 3 0 0 3 3 3 0 Ezrin/radixin/moesin family Clat_adaptor_s PF01217.15 ESL10850.1 - 3.9e-30 104.4 6.4 3e-17 62.6 1.3 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain PBP1_TM PF14812.1 ESL10851.1 - 2.9 8.2 8.0 0.33 11.2 2.5 1.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Metallophos PF00149.23 ESL10854.1 - 2.1e-36 125.2 0.5 5.4e-36 123.8 0.1 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL10854.1 - 0.0054 16.5 0.0 0.0089 15.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain EF-hand_8 PF13833.1 ESL10854.1 - 0.079 12.5 0.0 4.9 6.8 0.0 3.2 2 1 1 3 3 3 0 EF-hand domain pair Peptidase_M17 PF00883.16 ESL10855.1 - 4.5e-97 324.6 0.0 6.4e-97 324.1 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.12 ESL10855.1 - 2.1e-09 37.1 0.1 1.4e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain UPF0029 PF01205.14 ESL10856.1 - 0.071 12.8 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein family UPF0029 Macoilin PF09726.4 ESL10857.1 - 1.2 7.2 6.0 1.7 6.8 4.2 1.3 1 0 0 1 1 1 0 Transmembrane protein CDC45 PF02724.9 ESL10857.1 - 9.1 4.1 8.5 14 3.5 5.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Toxin_54 PF15533.1 ESL10858.1 - 0.22 11.8 0.0 0.38 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative toxin 54 Kringle PF00051.13 ESL10859.1 - 1.5e-18 66.6 0.3 3.4e-18 65.5 0.2 1.6 1 0 0 1 1 1 1 Kringle domain CHB_HEX_C_1 PF13290.1 ESL10859.1 - 2.2e-16 59.4 0.0 6e-14 51.5 0.0 3.4 3 0 0 3 3 3 1 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C PF03174.8 ESL10859.1 - 2.6e-16 59.2 0.0 1.6e-13 50.2 0.0 3.3 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 ESL10859.1 - 7.4e-13 48.3 0.0 3.2e-10 39.9 0.0 3.0 3 0 0 3 3 3 2 Fn3 associated RNase_HII PF01351.13 ESL10862.1 - 3.7e-26 92.0 0.0 2.8e-15 56.4 0.0 3.1 2 1 0 2 2 2 2 Ribonuclease HII DEAD PF00270.24 ESL10863.1 - 4.4e-32 110.9 0.1 2e-31 108.7 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL10863.1 - 6.1e-22 77.2 0.2 1.3e-21 76.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL10863.1 - 0.00023 21.0 0.0 0.00073 19.4 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3336 PF11815.3 ESL10866.1 - 1.9e-25 89.0 0.0 2.9e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 ESL10866.1 - 3.3e-12 46.7 0.0 5.3e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase PKI PF02827.11 ESL10867.1 - 0.53 10.4 8.1 0.48 10.5 1.6 2.9 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor Bac_DnaA_C PF08299.6 ESL10868.1 - 0.055 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein helix-turn-helix Jnk-SapK_ap_N PF09744.4 ESL10868.1 - 0.061 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Abhydro_lipase PF04083.11 ESL10868.1 - 0.077 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Cpn60_TCP1 PF00118.19 ESL10870.1 - 4.6e-119 398.2 4.3 5.3e-119 398.0 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glutaredoxin PF00462.19 ESL10871.1 - 2.9e-05 23.9 0.0 6.5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 ESL10871.1 - 4.1e-05 23.7 0.0 7.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESL10871.1 - 0.021 15.2 0.0 0.049 14.1 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESL10871.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Img2 PF05046.9 ESL10872.1 - 0.0059 16.8 0.0 0.009 16.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Mnd1 PF03962.10 ESL10873.1 - 0.56 9.8 14.5 0.1 12.2 4.2 2.2 1 1 1 2 2 2 0 Mnd1 family Peptidase_S46 PF10459.4 ESL10873.1 - 0.58 8.5 6.8 0.79 8.0 4.7 1.1 1 0 0 1 1 1 0 Peptidase S46 AATF-Che1 PF13339.1 ESL10873.1 - 0.64 10.1 5.8 45 4.1 3.5 2.6 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor FUSC PF04632.7 ESL10873.1 - 1.1 7.5 4.6 1.5 7.1 3.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pinin_SDK_memA PF04696.8 ESL10873.1 - 3.8 7.1 9.3 0.11 12.1 1.5 2.0 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region CorA PF01544.13 ESL10873.1 - 4.1 6.3 9.0 23 3.8 1.4 3.0 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein Pkinase PF00069.20 ESL10874.1 - 2.4e-56 190.7 0.0 2.7e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10874.1 - 7.2e-34 117.0 0.0 9e-34 116.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase TruB_C PF09142.6 ESL10874.1 - 0.058 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal ABC1 PF03109.11 ESL10874.1 - 0.14 12.0 0.0 0.35 10.8 0.0 1.6 2 0 0 2 2 2 0 ABC1 family GTP_EFTU PF00009.22 ESL10875.1 - 7.1e-55 185.3 0.0 1.2e-54 184.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL10875.1 - 6.6e-36 122.4 0.1 3.5e-35 120.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL10875.1 - 8.3e-18 64.2 0.6 8.3e-18 64.2 0.4 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 ESL10875.1 - 1.2e-05 24.7 0.1 4.8e-05 22.9 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 ESL10875.1 - 2.6e-05 24.1 0.0 0.0006 19.7 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL10875.1 - 0.0028 18.1 0.2 0.076 13.5 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 ESL10875.1 - 0.028 13.5 0.0 0.063 12.4 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Semialdhyde_dhC PF02774.13 ESL10875.1 - 0.031 14.1 0.1 0.38 10.5 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain zf-met PF12874.2 ESL10876.1 - 0.078 13.2 1.1 0.19 12.0 0.8 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Ribosomal_L18p PF00861.17 ESL10878.1 - 4e-38 130.2 0.3 4e-38 130.2 0.2 1.7 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 ESL10878.1 - 3.1e-24 85.3 6.8 3.1e-24 85.3 4.7 1.6 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region SNF2_N PF00176.18 ESL10879.1 - 7.9e-71 238.2 0.0 1.2e-70 237.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL10879.1 - 1.1e-15 57.2 0.0 3.4e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL10879.1 - 5.5e-06 26.3 0.0 0.00012 21.9 0.0 2.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 ESL10879.1 - 2.5e-05 23.8 0.0 7.4e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESL10879.1 - 0.029 14.4 0.1 0.21 11.7 0.0 2.6 2 1 1 3 3 3 0 AAA domain IPPT PF01715.12 ESL10880.1 - 2.6e-41 141.3 0.0 9.1e-36 123.1 0.0 2.2 2 0 0 2 2 2 2 IPP transferase zf-met PF12874.2 ESL10880.1 - 2.3e-06 27.6 0.6 5.1e-06 26.4 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type IPT PF01745.11 ESL10880.1 - 0.00019 20.6 0.0 0.021 13.9 0.0 2.4 2 0 0 2 2 2 1 Isopentenyl transferase zf-C2H2_jaz PF12171.3 ESL10880.1 - 0.00086 19.3 0.5 0.0021 18.1 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF2075 PF09848.4 ESL10880.1 - 0.012 14.5 0.1 0.026 13.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 ESL10880.1 - 0.014 15.4 0.0 0.13 12.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 ESL10880.1 - 0.04 13.1 0.0 0.32 10.1 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein CMAS PF02353.15 ESL10880.1 - 0.048 12.7 0.1 0.075 12.1 0.1 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Zot PF05707.7 ESL10880.1 - 0.074 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_17 PF13207.1 ESL10880.1 - 0.079 13.7 0.1 0.33 11.7 0.0 2.3 1 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESL10880.1 - 0.1 12.6 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Sec23_helical PF04815.10 ESL10882.1 - 3.3e-20 71.4 0.2 5.6e-20 70.7 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESL10882.1 - 2e-12 47.4 0.0 3.9e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 ESL10882.1 - 0.01 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Gelsolin repeat Dynamin_M PF01031.15 ESL10883.1 - 4.5e-88 294.8 0.3 8.9e-88 293.8 0.2 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 ESL10883.1 - 6.3e-50 169.2 0.0 2.6e-49 167.2 0.0 2.1 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 ESL10883.1 - 7.2e-24 83.5 0.2 3.5e-23 81.3 0.1 2.3 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 ESL10883.1 - 4.5e-05 23.3 0.0 0.00024 21.0 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESL10883.1 - 0.015 15.7 0.0 0.044 14.2 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Baculo_p74 PF04583.7 ESL10883.1 - 0.026 13.7 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 Baculoviridae p74 conserved region AAA_29 PF13555.1 ESL10883.1 - 0.058 12.9 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.13 ESL10883.1 - 0.12 11.5 1.0 9 5.5 0.0 3.6 4 0 0 4 4 4 0 Ferrous iron transport protein B SNase PF00565.12 ESL10886.1 - 1.4e-08 34.9 0.0 2.1e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Acetyltransf_1 PF00583.19 ESL10887.1 - 2.7e-15 56.1 0.0 4.6e-15 55.4 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL10887.1 - 1.3e-10 41.3 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL10887.1 - 3.1e-07 30.2 0.0 3.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL10887.1 - 7.6e-06 25.5 0.0 3.5e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.1 ESL10887.1 - 4.1e-05 23.6 0.0 4.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESL10887.1 - 0.0013 18.9 0.0 0.0016 18.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESL10887.1 - 0.004 17.1 0.0 0.0054 16.6 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 ESL10887.1 - 0.0054 16.5 0.0 0.008 16.0 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.1 ESL10887.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA PF00004.24 ESL10888.1 - 7.6e-44 149.1 0.0 1.4e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESL10888.1 - 9.6e-08 31.3 0.0 1.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESL10888.1 - 0.00025 21.0 0.1 0.013 15.5 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESL10888.1 - 0.00033 20.8 0.1 0.027 14.6 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESL10888.1 - 0.00038 20.4 0.0 0.0011 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Vps4_C PF09336.5 ESL10888.1 - 0.00041 20.1 0.1 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.9 ESL10888.1 - 0.0012 18.5 0.0 0.0047 16.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESL10888.1 - 0.0015 19.3 0.0 0.0034 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESL10888.1 - 0.0033 16.8 0.0 0.017 14.5 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL10888.1 - 0.0038 17.3 0.0 0.0078 16.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Zeta_toxin PF06414.7 ESL10888.1 - 0.0046 16.0 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 ESL10888.1 - 0.007 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESL10888.1 - 0.0078 16.0 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESL10888.1 - 0.015 14.4 0.1 0.028 13.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ESL10888.1 - 0.02 14.8 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESL10888.1 - 0.021 13.5 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_19 PF13245.1 ESL10888.1 - 0.042 13.5 0.5 0.65 9.7 0.0 2.9 3 0 0 3 3 3 0 Part of AAA domain AAA_18 PF13238.1 ESL10888.1 - 0.046 14.0 0.0 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 ESL10888.1 - 0.047 12.5 0.0 0.075 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF815 PF05673.8 ESL10888.1 - 0.051 12.4 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 ESL10888.1 - 0.067 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 ESL10888.1 - 0.07 12.5 0.5 0.93 8.8 0.1 2.5 2 1 1 3 3 2 0 AAA domain SKI PF01202.17 ESL10888.1 - 0.12 12.2 0.0 0.33 10.7 0.0 1.8 1 0 0 1 1 1 0 Shikimate kinase KaiC PF06745.8 ESL10888.1 - 0.16 11.0 0.0 0.35 9.9 0.0 1.5 1 0 0 1 1 1 0 KaiC PhoH PF02562.11 ESL10888.1 - 0.19 10.9 0.0 0.36 10.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein HTH_44 PF14641.1 ESL10888.1 - 0.2 11.6 0.0 0.39 10.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 zf-MIZ PF02891.15 ESL10889.1 - 3.3e-10 39.2 4.5 3.3e-10 39.2 3.1 2.2 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 ESL10889.1 - 1.9e-05 24.0 1.7 4.6e-05 22.8 1.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit LRR_6 PF13516.1 ESL10890.1 - 7.2e-08 31.7 2.6 0.00028 20.6 0.0 3.8 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.28 ESL10890.1 - 0.051 13.6 0.6 0.39 10.9 0.0 2.8 2 2 0 2 2 2 0 Leucine Rich Repeat Galactosyl_T PF01762.16 ESL10891.1 - 0.005 16.4 0.0 0.29 10.7 0.0 2.9 3 0 0 3 3 3 1 Galactosyltransferase Glyco_hydro_85 PF03644.8 ESL10892.1 - 1.7e-89 300.0 0.0 2.6e-89 299.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Peptidase_C97 PF05903.9 ESL10892.1 - 1.3e-28 99.7 0.0 1.9e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUB PF09409.5 ESL10892.1 - 1.6e-10 40.5 0.0 3.2e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 PUB domain COQ7 PF03232.8 ESL10893.1 - 6.1e-62 208.1 0.9 7.4e-62 207.8 0.6 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 PTH2 PF01981.11 ESL10893.1 - 0.024 14.3 0.1 0.052 13.2 0.1 1.5 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 Peptidase_M2 PF01401.13 ESL10893.1 - 0.047 11.8 0.0 0.067 11.3 0.0 1.1 1 0 0 1 1 1 0 Angiotensin-converting enzyme Sec20 PF03908.8 ESL10894.1 - 0.0032 17.1 1.7 0.0048 16.5 1.2 1.2 1 0 0 1 1 1 1 Sec20 Pox_F16 PF04708.7 ESL10894.1 - 0.0044 16.3 0.4 0.0053 16.0 0.3 1.2 1 0 0 1 1 1 1 Poxvirus F16 protein Hepatitis_core PF00906.15 ESL10894.1 - 0.084 12.5 0.1 0.098 12.3 0.1 1.1 1 0 0 1 1 1 0 Hepatitis core antigen MORN PF02493.15 ESL10895.1 - 7.8e-63 204.6 111.3 1.4e-06 27.7 0.7 24.1 23 2 0 23 23 23 20 MORN repeat ATG16 PF08614.6 ESL10895.1 - 0.016 15.0 2.7 0.25 11.1 1.9 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) UBA_4 PF14555.1 ESL10896.1 - 1.7e-08 33.8 0.9 2.9e-08 33.0 0.6 1.4 1 0 0 1 1 1 1 UBA-like domain End_beta_propel PF12217.3 ESL10896.1 - 0.097 11.3 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Catalytic beta propeller domain of bacteriophage endosialidase AAA PF00004.24 ESL10898.1 - 2.4e-38 131.3 0.0 8.2e-38 129.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL10898.1 - 7.1e-08 32.6 0.0 2.1e-05 24.6 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL10898.1 - 1e-06 28.8 0.1 1.1e-05 25.4 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 ESL10898.1 - 1.1e-06 27.9 0.0 2.8e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESL10898.1 - 1.1e-06 28.4 0.0 4.6e-06 26.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESL10898.1 - 2e-06 28.6 0.0 4.5e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL10898.1 - 3e-06 26.1 0.1 2.6e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 TIP49 C-terminus AAA_33 PF13671.1 ESL10898.1 - 1.2e-05 25.2 0.0 1.8e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL10898.1 - 1.4e-05 24.3 0.0 2.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 ESL10898.1 - 2.4e-05 24.2 0.0 4.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 ESL10898.1 - 3.2e-05 23.7 0.0 5.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein SKI PF01202.17 ESL10898.1 - 0.00024 20.9 0.0 0.00056 19.8 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase IstB_IS21 PF01695.12 ESL10898.1 - 0.00036 19.9 0.0 0.00056 19.3 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 ESL10898.1 - 0.00051 20.3 0.0 0.0029 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESL10898.1 - 0.00083 19.5 0.0 0.0026 17.8 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 ESL10898.1 - 0.0013 18.3 0.0 0.0038 16.9 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 ESL10898.1 - 0.0025 17.2 0.7 0.085 12.2 0.1 2.2 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.16 ESL10898.1 - 0.0034 16.5 0.1 0.0077 15.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESL10898.1 - 0.0039 16.7 0.0 0.0066 16.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ESL10898.1 - 0.006 16.6 0.0 0.012 15.6 0.0 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain PhoH PF02562.11 ESL10898.1 - 0.0064 15.7 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_24 PF13479.1 ESL10898.1 - 0.007 15.9 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESL10898.1 - 0.007 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) NACHT PF05729.7 ESL10898.1 - 0.0078 15.8 0.0 0.016 14.8 0.0 1.5 1 1 0 1 1 1 1 NACHT domain AAA_28 PF13521.1 ESL10898.1 - 0.018 15.0 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESL10898.1 - 0.018 14.6 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Vps4_C PF09336.5 ESL10898.1 - 0.019 14.8 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain UPF0079 PF02367.12 ESL10898.1 - 0.022 14.4 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Arch_ATPase PF01637.13 ESL10898.1 - 0.024 14.3 0.0 1 9.0 0.0 2.3 1 1 1 2 2 2 0 Archaeal ATPase Parvo_NS1 PF01057.12 ESL10898.1 - 0.024 13.5 0.0 0.052 12.4 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 ESL10898.1 - 0.025 14.0 0.0 0.081 12.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain CPT PF07931.7 ESL10898.1 - 0.032 13.8 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.1 ESL10898.1 - 0.04 13.4 0.0 0.082 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IPT PF01745.11 ESL10898.1 - 0.051 12.7 0.0 0.71 9.0 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase DUF2075 PF09848.4 ESL10898.1 - 0.082 11.8 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.10 ESL10898.1 - 0.088 11.4 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF815 PF05673.8 ESL10898.1 - 0.16 10.8 0.0 0.35 9.7 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF815) Cullin PF00888.17 ESL10899.1 - 1.1e-59 202.5 0.0 1.8e-59 201.8 0.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESL10899.1 - 3.3e-16 58.8 0.0 1e-15 57.3 0.0 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF3439 PF11921.3 ESL10899.1 - 0.044 13.5 2.5 0.12 12.1 1.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) S4 PF01479.20 ESL10900.1 - 1.1e-06 27.9 0.6 3.6e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 S4 domain PseudoU_synth_2 PF00849.17 ESL10900.1 - 2.5e-05 24.1 0.0 4.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase V-ATPase_C PF03223.10 ESL10901.1 - 1.2e-93 314.0 1.2 1.3e-93 313.8 0.8 1.0 1 0 0 1 1 1 1 V-ATPase subunit C BCIP PF13862.1 ESL10901.1 - 0.04 13.4 0.2 0.11 12.0 0.1 1.6 1 0 0 1 1 1 0 p21-C-terminal region-binding protein DUF2735 PF10931.3 ESL10903.1 - 0.17 12.1 0.5 0.78 10.0 0.1 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2735) Elf1 PF05129.8 ESL10904.1 - 0.0026 17.4 5.3 0.0026 17.4 3.6 2.1 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like C1_2 PF03107.11 ESL10904.1 - 0.034 14.2 3.2 0.034 14.2 2.2 2.2 3 0 0 3 3 3 0 C1 domain zinc_ribbon_2 PF13240.1 ESL10904.1 - 0.18 11.3 8.6 0.045 13.2 1.4 3.0 3 0 0 3 3 3 0 zinc-ribbon domain CENP-N PF05238.8 ESL10905.1 - 0.075 12.0 0.5 0.14 11.2 0.4 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like AdoMetDC_leader PF08132.6 ESL10909.1 - 0.15 11.9 0.0 0.5 10.3 0.0 1.8 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide NTF2 PF02136.15 ESL10910.1 - 1.8e-25 89.5 0.0 2e-25 89.4 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_2 PF12680.2 ESL10910.1 - 0.0059 17.0 0.0 0.0064 16.8 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain Lumazine_bd_2 PF12893.2 ESL10910.1 - 0.019 15.4 0.1 0.023 15.2 0.0 1.5 1 1 0 1 1 1 0 Putative lumazine-binding Pkinase PF00069.20 ESL10911.1 - 6.7e-57 192.5 0.0 1.8e-56 191.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10911.1 - 8.4e-32 110.2 0.0 1.4e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CBFD_NFYB_HMF PF00808.18 ESL10911.1 - 0.00099 19.1 0.1 0.083 12.9 0.0 3.1 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Kinase-like PF14531.1 ESL10911.1 - 0.0015 17.5 0.0 0.0046 15.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pox_ser-thr_kin PF05445.6 ESL10911.1 - 0.025 13.4 0.0 0.035 12.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MscS_porin PF12795.2 ESL10911.1 - 1.1 8.5 18.0 0.53 9.5 4.2 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Glyco_trans_1_2 PF13524.1 ESL10911.1 - 5.1 7.4 8.4 0.63 10.3 0.2 3.1 2 1 0 3 3 3 0 Glycosyl transferases group 1 Aminotran_1_2 PF00155.16 ESL10912.1 - 7.1e-33 114.0 0.0 9.2e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Ala_racemase_N PF01168.15 ESL10912.1 - 0.031 13.8 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain TMEM18 PF14770.1 ESL10913.1 - 1.5e-31 108.4 5.5 2e-31 108.0 3.8 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 TTL PF03133.10 ESL10914.1 - 4.6e-45 153.8 0.0 1e-20 73.8 0.0 3.1 2 1 0 2 2 2 2 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.9 ESL10914.1 - 0.043 13.6 0.0 3.7 7.3 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Frankia_peptide PF14407.1 ESL10914.1 - 0.057 13.1 0.3 13 5.6 0.5 2.5 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. MacB_PCD PF12704.2 ESL10915.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 MacB-like periplasmic core domain Reo_sigmaC PF04582.7 ESL10916.1 - 0.93 8.6 7.1 17 4.4 0.4 3.4 2 2 2 4 4 4 0 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 ESL10916.1 - 1 6.9 65.2 0.19 9.4 18.0 2.5 2 1 0 2 2 2 0 Myosin tail CAF-1_p150 PF11600.3 ESL10918.1 - 0.16 11.3 11.0 0.24 10.7 7.7 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal V_ATPase_I PF01496.14 ESL10918.1 - 0.39 8.5 5.0 0.56 7.9 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF342 PF03961.8 ESL10918.1 - 3.4 5.9 7.1 11 4.2 5.4 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF342) CorA PF01544.13 ESL10918.1 - 4.5 6.2 5.3 86 2.0 4.9 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein ERM PF00769.14 ESL10918.1 - 9.5 5.6 26.5 2.6 7.5 15.6 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family GOLGA2L5 PF15070.1 ESL10919.1 - 0.013 13.9 2.6 0.02 13.3 1.8 1.3 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 DivIC PF04977.10 ESL10919.1 - 0.08 12.4 0.8 5.7 6.5 0.1 2.4 2 0 0 2 2 2 0 Septum formation initiator TBPIP PF07106.8 ESL10919.1 - 0.17 11.4 1.1 0.5 9.8 0.8 1.8 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Zip PF02535.17 ESL10920.1 - 2 7.3 8.6 0.095 11.6 1.3 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Tom5 PF10642.4 ESL10920.1 - 2.3 7.9 4.9 0.53 9.9 0.3 2.2 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase ADH_N PF08240.7 ESL10921.1 - 2.8e-07 30.2 0.1 5.1e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESL10921.1 - 0.00025 20.6 0.0 0.00076 19.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase TylF PF05711.6 ESL10922.1 - 2e-15 56.5 0.0 2.3e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 ESL10922.1 - 3.3e-07 31.0 0.0 5.2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Trm56 PF01994.11 ESL10922.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 GMP_PDE_delta PF05351.6 ESL10923.1 - 7.9e-65 217.4 0.1 9.2e-65 217.2 0.1 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit WD40 PF00400.27 ESL10924.1 - 9e-06 25.3 0.2 8.8e-05 22.2 0.1 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Choline_sulf_C PF12411.3 ESL10925.1 - 0.058 13.2 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Choline sulfatase enzyme C terminal Pkinase PF00069.20 ESL10926.1 - 0.0026 16.9 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF846 PF05832.7 ESL10927.1 - 1.8e-42 144.3 8.0 2.4e-42 144.0 5.6 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMEM220 PF15071.1 ESL10927.1 - 0.031 14.7 1.7 0.079 13.4 0.1 2.0 2 0 0 2 2 2 0 Transmembrane family 220, helix zf-RanBP PF00641.13 ESL10928.1 - 3.8e-20 70.6 58.1 6e-07 28.4 1.5 7.4 8 0 0 8 8 8 5 Zn-finger in Ran binding protein and others FYVE PF01363.16 ESL10928.1 - 2.6e-17 62.4 12.6 2.6e-17 62.4 8.7 4.7 3 2 0 3 3 3 1 FYVE zinc finger DZR PF12773.2 ESL10928.1 - 0.0052 16.5 49.9 0.086 12.6 5.1 5.9 2 2 3 6 6 6 5 Double zinc ribbon WD40 PF00400.27 ESL10929.1 - 2.2e-16 59.0 25.3 4e-06 26.5 0.0 7.2 8 0 0 8 8 8 5 WD domain, G-beta repeat Adeno_PV PF03910.8 ESL10931.1 - 0.021 13.9 0.3 0.028 13.4 0.2 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV Peptidase_M1 PF01433.15 ESL10932.1 - 6.2e-95 318.5 0.0 8.5e-95 318.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 ESL10932.1 - 8.5e-15 54.8 0.0 1.2e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 ESL10932.1 - 3.4e-14 52.9 0.0 7.3e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase MA superfamily LRR_6 PF13516.1 ESL10933.1 - 7.3e-17 59.4 7.9 0.0015 18.4 0.0 6.8 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.2 ESL10933.1 - 1.1e-10 40.8 4.2 0.0081 15.7 0.0 3.9 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL10933.1 - 3.8e-06 26.1 8.5 2.4 8.5 0.0 6.9 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.1 ESL10933.1 - 7.8e-06 25.5 9.4 0.44 10.3 0.8 4.9 3 1 2 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 ESL10933.1 - 0.0021 17.9 14.4 15 6.3 0.0 7.2 7 0 0 7 7 7 1 Leucine rich repeat Cyclin_N PF00134.18 ESL10934.1 - 9.9e-11 41.3 1.3 1.6e-10 40.6 0.9 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain CDC37_N PF03234.9 ESL10935.1 - 4.4 7.6 19.7 3.3 8.0 11.8 1.9 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Ribosomal_S7e PF01251.13 ESL10936.1 - 2.7e-66 222.7 1.4 3e-66 222.5 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e SUV3_C PF12513.3 ESL10937.1 - 2.3e-14 52.5 1.6 3.6e-14 51.9 0.4 1.9 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 ESL10937.1 - 9.5e-08 31.7 0.0 1.9e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL10937.1 - 0.01 15.3 0.0 0.038 13.4 0.0 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase Arch_ATPase PF01637.13 ESL10937.1 - 0.041 13.5 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase Kinesin PF00225.18 ESL10937.1 - 0.1 11.2 0.0 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 Kinesin motor domain SHS2_Rpb7-N PF03876.12 ESL10938.1 - 2.1e-16 59.8 0.0 3.6e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 FYVE PF01363.16 ESL10939.1 - 2e-07 30.8 8.4 5.1e-07 29.4 5.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger Spc42p PF11544.3 ESL10939.1 - 0.012 15.5 0.7 0.012 15.5 0.5 2.9 2 0 0 2 2 2 0 Spindle pole body component Spc42p IBR PF01485.16 ESL10939.1 - 0.017 14.9 3.2 0.017 14.9 2.2 2.1 2 0 0 2 2 2 0 IBR domain eIF-1a PF01176.14 ESL10940.1 - 4.7e-17 61.1 0.2 8.3e-17 60.3 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 GrpB PF04229.9 ESL10940.1 - 0.075 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 GrpB protein HTH_DeoR PF08220.7 ESL10942.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain RebB PF11747.3 ESL10942.1 - 1.2 9.0 3.6 9.1 6.2 0.0 3.1 3 0 0 3 3 3 0 Killing trait MAM33 PF02330.11 ESL10944.1 - 4.9e-08 32.9 0.0 7.5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein Ank_2 PF12796.2 ESL10945.1 - 6.2e-05 23.2 0.0 0.00014 22.1 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) ANAPC15 PF15243.1 ESL10945.1 - 0.0019 18.2 17.7 0.0026 17.7 7.8 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 15 Ank PF00023.25 ESL10945.1 - 0.0052 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.1 ESL10945.1 - 0.07 13.6 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Astro_capsid PF03115.9 ESL10945.1 - 0.11 10.7 4.1 0.16 10.1 2.8 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF607 PF04678.8 ESL10945.1 - 0.85 9.5 4.9 0.51 10.2 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF607 FYDLN_acid PF09538.5 ESL10945.1 - 1 9.9 22.9 0.52 10.9 10.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Cwf_Cwc_15 PF04889.7 ESL10945.1 - 3.3 7.3 23.7 3 7.4 9.1 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.4 ESL10945.1 - 4.2 5.9 25.8 2.2 6.9 13.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) ERCC4 PF02732.10 ESL10946.1 - 2.1e-15 56.6 0.0 9.2e-15 54.6 0.0 2.2 3 0 0 3 3 3 1 ERCC4 domain Sel1 PF08238.7 ESL10947.1 - 0.22 12.2 7.7 1.8 9.3 0.1 4.4 4 1 0 4 4 4 0 Sel1 repeat DUF87 PF01935.12 ESL10947.1 - 0.79 9.4 4.0 1.3 8.7 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 Peptidase_S46 PF10459.4 ESL10947.1 - 6.3 5.0 11.2 9.5 4.4 7.8 1.2 1 0 0 1 1 1 0 Peptidase S46 Laminin_N PF00055.12 ESL10949.1 - 0.087 11.7 0.0 0.27 10.2 0.0 1.8 1 0 0 1 1 1 0 Laminin N-terminal (Domain VI) ATP-synt_C PF00137.16 ESL10950.1 - 2.7e-26 91.2 38.5 6.3e-15 54.8 7.8 2.6 3 0 0 3 3 3 2 ATP synthase subunit C AAA_16 PF13191.1 ESL10951.1 - 0.0003 20.8 0.1 0.00068 19.6 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.10 ESL10951.1 - 0.00089 18.0 0.0 0.003 16.2 0.0 1.7 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESL10951.1 - 0.11 12.6 0.0 0.34 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Rieske_2 PF13806.1 ESL10952.1 - 3.9e-09 36.1 0.0 9.5e-09 34.9 0.0 1.7 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.21 ESL10952.1 - 1.1e-06 28.0 1.5 2.8e-06 26.8 0.7 1.8 1 1 1 2 2 2 1 Rieske [2Fe-2S] domain FAD_binding_6 PF00970.19 ESL10952.1 - 0.0036 17.3 0.0 0.0066 16.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain IncA PF04156.9 ESL10953.1 - 0.00019 21.0 15.3 0.00019 21.0 10.6 6.4 4 2 1 6 6 6 2 IncA protein GRAB PF10375.4 ESL10953.1 - 0.0008 18.9 0.3 0.0016 18.0 0.2 1.4 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Reo_sigmaC PF04582.7 ESL10953.1 - 0.014 14.6 31.6 0.33 10.0 2.3 4.6 2 1 1 4 4 4 0 Reovirus sigma C capsid protein Metallophos PF00149.23 ESL10954.1 - 2.5e-38 131.4 0.2 3.5e-38 131.0 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 ESL10954.1 - 3.6e-23 81.3 0.0 6.7e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_11 PF13414.1 ESL10954.1 - 6.6e-21 73.7 3.8 8.3e-15 54.1 1.4 2.3 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESL10954.1 - 1.5e-17 62.3 4.1 3.6e-07 29.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL10954.1 - 1.8e-13 49.2 5.1 2.6e-05 23.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESL10954.1 - 5.8e-07 30.0 4.3 0.00059 20.4 1.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL10954.1 - 9.3e-07 28.2 1.2 0.00064 19.3 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESL10954.1 - 2.2e-06 27.4 5.2 0.0039 17.0 1.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL10954.1 - 4e-06 26.9 0.3 0.0071 16.8 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESL10954.1 - 5.7e-05 22.3 0.2 0.018 14.0 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL10954.1 - 7.4e-05 22.2 0.0 0.083 12.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat BTAD PF03704.12 ESL10954.1 - 0.00014 22.2 0.3 0.00024 21.4 0.2 1.3 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_9 PF13371.1 ESL10954.1 - 0.00027 20.7 0.5 0.0015 18.3 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL10954.1 - 0.00064 19.8 1.9 0.0069 16.4 1.6 2.4 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESL10954.1 - 0.0017 18.3 2.0 0.013 15.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL10954.1 - 0.0068 16.7 3.4 5.3 7.4 2.3 2.9 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL10954.1 - 0.011 16.1 0.0 0.45 11.0 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.2 ESL10954.1 - 0.11 12.3 0.0 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) CTP_synth_N PF06418.9 ESL10955.1 - 6.3e-56 189.4 0.0 7.2e-56 189.2 0.0 1.0 1 0 0 1 1 1 1 CTP synthase N-terminus NAAA-beta PF15508.1 ESL10955.1 - 0.051 13.9 0.0 0.078 13.3 0.0 1.2 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Peptidase_M8 PF01457.11 ESL10956.1 - 0.0015 16.9 0.2 0.0018 16.7 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_C2 PF00648.16 ESL10957.1 - 3.7e-49 167.3 0.0 5.3e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESL10957.1 - 5.9e-34 116.1 0.1 1.2e-33 115.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF3470 PF11953.3 ESL10957.1 - 0.0058 16.2 0.1 0.015 14.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3470) UbiA PF01040.13 ESL10959.1 - 5.4e-32 111.0 21.0 9.3e-32 110.2 14.6 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF2036 PF09724.4 ESL10960.1 - 1.6e-70 237.8 0.0 1.9e-70 237.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) VCBS PF13517.1 ESL10961.1 - 7.6e-10 39.0 8.7 0.031 14.6 0.3 5.1 4 1 0 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 ESL10961.1 - 2.1e-07 30.4 14.0 0.066 12.9 0.0 5.5 5 0 0 5 5 5 3 FG-GAP repeat TcdB_toxin_midN PF12256.3 ESL10961.1 - 0.026 13.9 2.2 10 5.5 0.0 4.1 4 1 1 5 5 5 0 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.1 ESL10961.1 - 0.075 12.4 0.4 2.5 7.6 0.1 2.7 2 0 0 2 2 2 0 EF hand Peptidase_M41 PF01434.13 ESL10962.1 - 6.8e-65 218.5 1.6 9.3e-65 218.0 1.1 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESL10962.1 - 2.5e-43 147.4 0.0 5.8e-43 146.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESL10962.1 - 3.9e-07 29.6 0.3 0.00026 20.4 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.9 ESL10962.1 - 1e-06 28.4 0.0 5.7e-06 26.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESL10962.1 - 1.9e-05 23.8 0.0 6.9e-05 22.0 0.0 2.0 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESL10962.1 - 2.7e-05 24.3 0.1 0.0025 17.9 0.0 2.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESL10962.1 - 5.4e-05 23.0 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL10962.1 - 6.9e-05 22.9 0.1 0.0054 16.7 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 ESL10962.1 - 0.00017 22.3 0.0 0.00038 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 ESL10962.1 - 0.00034 20.3 0.0 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 Bacterial dnaA protein NACHT PF05729.7 ESL10962.1 - 0.00035 20.2 0.0 0.011 15.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain TIP49 PF06068.8 ESL10962.1 - 0.0011 17.8 0.0 0.0028 16.4 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESL10962.1 - 0.0011 18.4 0.0 0.0025 17.2 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 ESL10962.1 - 0.0017 18.2 0.0 0.0039 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESL10962.1 - 0.0019 17.3 0.0 0.0042 16.1 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 ESL10962.1 - 0.0041 16.2 0.2 0.0079 15.3 0.1 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 ESL10962.1 - 0.006 16.5 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 ESL10962.1 - 0.0062 16.8 0.0 0.017 15.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.1 ESL10962.1 - 0.0071 16.0 0.1 0.029 14.0 0.0 2.1 2 0 0 2 2 1 1 Part of AAA domain AAA_28 PF13521.1 ESL10962.1 - 0.0078 16.1 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ESL10962.1 - 0.021 15.1 0.1 0.11 12.8 0.0 2.2 2 0 0 2 2 1 0 ABC transporter RNA_helicase PF00910.17 ESL10962.1 - 0.021 15.0 0.0 0.064 13.4 0.0 2.0 1 1 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.20 ESL10962.1 - 0.035 13.5 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.10 ESL10962.1 - 0.068 11.8 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NB-ARC PF00931.17 ESL10962.1 - 0.076 11.8 0.4 0.2 10.4 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain Arch_ATPase PF01637.13 ESL10962.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 1 1 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 ESL10962.1 - 0.12 11.7 0.1 0.52 9.7 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain HSP70 PF00012.15 ESL10963.1 - 4.3e-106 355.2 1.4 4.8e-106 355.0 1.0 1.0 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.11 ESL10963.1 - 0.00065 19.3 0.1 0.01 15.5 0.0 2.4 3 0 0 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4613 PF15390.1 ESL10963.1 - 0.42 8.7 1.9 0.56 8.3 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF2458 PF10454.4 ESL10963.1 - 0.48 10.2 4.6 0.94 9.3 3.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) Gyro_capsid PF04162.7 ESL10964.1 - 0.15 10.2 0.0 0.21 9.8 0.0 1.1 1 0 0 1 1 1 0 Gyrovirus capsid protein (VP1) Pkinase PF00069.20 ESL10967.1 - 2.8e-53 180.7 0.0 3.7e-53 180.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10967.1 - 3.7e-33 114.7 0.0 5.2e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL10967.1 - 0.00054 19.0 0.0 0.0013 17.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESL10967.1 - 0.0027 17.4 0.0 0.072 12.8 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESL10967.1 - 0.065 12.0 0.0 0.093 11.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinesin PF00225.18 ESL10968.1 - 9.4e-87 290.8 0.1 2.2e-86 289.5 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain KaiC PF06745.8 ESL10968.1 - 0.14 11.2 3.5 2.1 7.3 0.1 3.0 3 0 0 3 3 3 0 KaiC DUF1515 PF07439.6 ESL10968.1 - 3.4 7.5 15.0 3.1 7.6 0.4 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1515) WD40 PF00400.27 ESL10969.1 - 2.3e-28 97.0 18.2 1.4e-07 31.0 0.1 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat RasGAP PF00616.14 ESL10971.1 - 0.093 12.3 0.0 0.31 10.6 0.0 1.9 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase Ca_chan_IQ PF08763.6 ESL10972.1 - 2 7.7 9.4 0.51 9.6 2.0 2.5 2 0 0 2 2 2 0 Voltage gated calcium channel IQ domain Glyoxalase PF00903.20 ESL10973.1 - 0.089 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PUF PF00806.14 ESL10974.1 - 1.1e-48 160.0 6.2 2.4e-05 23.5 0.0 8.2 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Herpes_ICP4_N PF03584.10 ESL10974.1 - 0.0033 16.9 0.0 0.0074 15.8 0.0 1.5 1 0 0 1 1 1 1 Herpesvirus ICP4-like protein N-terminal region SMK-1 PF04802.10 ESL10976.1 - 0.00037 20.0 0.0 0.00098 18.6 0.0 1.7 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 DAP10 PF07213.6 ESL10979.1 - 0.054 13.2 0.2 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 DAP10 membrane protein IncA PF04156.9 ESL10979.1 - 0.18 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 IncA protein HECT PF00632.20 ESL10980.1 - 8.3e-76 255.1 0.0 1.3e-75 254.4 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ZZ PF00569.12 ESL10980.1 - 0.0048 16.4 7.9 0.011 15.2 5.5 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type UvrD_C PF13361.1 ESL10980.1 - 0.17 11.3 0.4 1.3 8.3 0.4 2.3 2 1 0 2 2 2 0 UvrD-like helicase C-terminal domain Uteroglobin PF01099.12 ESL10981.1 - 0.015 15.0 0.7 0.053 13.3 0.5 1.9 1 0 0 1 1 1 0 Uteroglobin family DUF932 PF06067.6 ESL10981.1 - 0.064 12.5 3.8 0.11 11.7 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF932) Spc7 PF08317.6 ESL10981.1 - 0.2 10.2 24.2 0.036 12.7 13.4 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 ESL10981.1 - 0.75 9.6 17.1 1.3 8.8 6.4 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding KxDL PF10241.4 ESL10981.1 - 6.4 6.7 12.4 5.2 7.0 2.5 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein DUF342 PF03961.8 ESL10981.1 - 7.5 4.8 12.0 10 4.4 7.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Brix PF04427.13 ESL10982.1 - 2.7e-40 138.0 0.0 4.1e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 Brix domain M-factor PF03855.8 ESL10982.1 - 0.21 11.6 0.6 0.99 9.4 0.0 2.3 3 0 0 3 3 3 0 M-factor WD40 PF00400.27 ESL10984.1 - 2.8e-21 74.5 19.4 9e-12 44.3 1.4 7.6 8 0 0 8 8 8 4 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESL10984.1 - 3.9e-05 22.6 5.8 0.0069 15.2 0.3 5.0 4 1 2 6 6 6 1 Coatomer WD associated region Clathrin PF00637.15 ESL10984.1 - 0.001 18.6 3.7 1.1 8.8 0.0 3.4 2 1 1 3 3 3 2 Region in Clathrin and VPS TPR_7 PF13176.1 ESL10984.1 - 0.0074 16.0 3.2 14 5.8 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.15 ESL10984.1 - 0.021 14.7 1.6 61 3.9 0.1 4.3 3 0 0 3 3 3 0 PPR repeat TPR_2 PF07719.12 ESL10984.1 - 0.055 13.4 21.3 0.02 14.7 0.9 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR_2 PF13041.1 ESL10984.1 - 0.064 13.2 4.1 6.8 6.7 0.2 4.0 4 0 0 4 4 4 0 PPR repeat family Kelch_2 PF07646.10 ESL10984.1 - 0.14 12.0 1.5 19 5.2 0.0 2.9 2 0 0 2 2 2 0 Kelch motif TPR_11 PF13414.1 ESL10984.1 - 0.15 11.7 4.9 6.6 6.4 0.3 3.4 3 0 0 3 3 3 0 TPR repeat TPR_14 PF13428.1 ESL10984.1 - 2.5 8.9 9.4 25 5.8 0.4 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL10984.1 - 3.1 7.5 11.6 3.5 7.4 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL10984.1 - 3.9 7.4 12.1 0.51 10.3 0.3 4.1 5 1 0 5 5 5 0 Tetratricopeptide repeat zf-RING_3 PF14369.1 ESL10984.1 - 7.9 6.5 12.6 1 9.4 3.2 3.2 3 0 0 3 3 3 0 zinc-finger MMS19_C PF12460.3 ESL10985.1 - 0.08 11.6 0.0 0.08 11.6 0.0 1.1 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal RCC1 PF00415.13 ESL10986.1 - 1.3e-35 121.3 19.6 3.9e-10 39.7 0.1 7.5 6 2 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL10986.1 - 9.2e-34 114.3 38.1 3.9e-11 42.2 1.0 7.5 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat DnaJ PF00226.26 ESL10988.1 - 0.11 12.2 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 DnaJ domain 5_3_exonuc_N PF02739.11 ESL10989.1 - 0.016 14.5 0.0 0.036 13.4 0.0 1.5 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF2000 PF09391.5 ESL10989.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) Pkinase PF00069.20 ESL10991.1 - 9.8e-55 185.4 0.0 1.4e-54 184.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL10991.1 - 1.2e-28 99.9 0.0 2.5e-28 98.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESL10991.1 - 0.00059 19.6 0.1 0.24 11.0 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 ESL10991.1 - 0.0038 16.5 0.0 0.0063 15.8 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESL10991.1 - 0.01 14.9 0.0 0.021 13.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RsbRD_N PF14361.1 ESL10991.1 - 0.04 14.3 0.0 0.075 13.4 0.0 1.5 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain Ras PF00071.17 ESL10992.1 - 1.4e-44 151.3 0.0 1.7e-44 151.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL10992.1 - 3.8e-15 56.4 0.0 8.2e-15 55.3 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESL10992.1 - 5.8e-14 51.6 0.0 7.3e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL10992.1 - 4.4e-06 26.0 0.0 5.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL10992.1 - 0.00022 21.1 0.0 0.0003 20.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL10992.1 - 0.00086 18.7 0.0 0.0026 17.2 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.1 ESL10992.1 - 0.003 17.1 0.0 0.0051 16.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESL10992.1 - 0.0049 16.0 0.0 0.015 14.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESL10992.1 - 0.006 16.0 0.2 0.018 14.5 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.1 ESL10992.1 - 0.009 15.4 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL10992.1 - 0.047 13.6 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 ESL10992.1 - 0.048 13.9 0.1 0.051 13.8 0.0 1.5 1 1 0 1 1 1 0 ABC transporter YTH PF04146.10 ESL10992.1 - 0.058 12.9 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 YT521-B-like domain ATP_bind_1 PF03029.12 ESL10992.1 - 0.086 12.3 0.1 0.68 9.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein MCM PF00493.18 ESL10992.1 - 0.089 11.5 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family RPAP2_Rtr1 PF04181.8 ESL10993.1 - 2.2e-13 50.1 1.7 2.2e-13 50.1 1.2 2.0 2 1 0 2 2 2 1 Rtr1/RPAP2 family AAA PF00004.24 ESL10994.1 - 2.8e-36 124.6 0.0 3e-29 101.8 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL10994.1 - 3.2e-14 53.1 0.1 5.2e-05 23.4 0.0 3.9 3 1 1 4 4 3 2 AAA domain AAA_16 PF13191.1 ESL10994.1 - 9.7e-12 45.2 0.4 0.00015 21.8 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 ESL10994.1 - 2.9e-09 37.7 0.3 0.00029 21.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 ESL10994.1 - 4.5e-09 35.7 0.3 0.0024 17.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESL10994.1 - 8.5e-09 35.0 0.8 0.00066 19.3 0.1 2.7 2 0 0 2 2 2 2 Part of AAA domain AAA_5 PF07728.9 ESL10994.1 - 6.3e-08 32.4 0.4 0.006 16.3 0.0 3.1 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) TIP49 PF06068.8 ESL10994.1 - 1.7e-07 30.3 0.0 0.011 14.4 0.0 2.1 2 0 0 2 2 2 2 TIP49 C-terminus AAA_25 PF13481.1 ESL10994.1 - 8e-07 28.6 0.6 0.013 14.9 0.0 3.9 2 2 1 3 3 3 2 AAA domain AAA_18 PF13238.1 ESL10994.1 - 1.1e-06 28.9 0.1 0.0016 18.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESL10994.1 - 1.6e-06 27.6 0.0 0.0061 15.9 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_33 PF13671.1 ESL10994.1 - 2.2e-06 27.6 0.2 0.019 14.8 0.0 2.8 3 0 0 3 3 2 2 AAA domain KaiC PF06745.8 ESL10994.1 - 2.3e-06 26.9 0.0 0.071 12.2 0.0 3.4 2 1 1 3 3 3 2 KaiC AAA_2 PF07724.9 ESL10994.1 - 6.8e-06 26.1 0.0 0.00073 19.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) NACHT PF05729.7 ESL10994.1 - 1.3e-05 24.9 0.1 0.088 12.4 0.0 3.1 3 0 0 3 3 3 2 NACHT domain AAA_11 PF13086.1 ESL10994.1 - 1.3e-05 24.9 0.0 0.018 14.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 ESL10994.1 - 2.7e-05 23.3 0.0 0.031 13.2 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.7 ESL10994.1 - 6.6e-05 22.0 0.2 0.09 11.8 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 ESL10994.1 - 0.0001 22.4 0.0 0.37 10.9 0.0 2.5 2 0 0 2 2 2 2 RNA helicase NB-ARC PF00931.17 ESL10994.1 - 0.0001 21.2 0.0 0.015 14.1 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.1 ESL10994.1 - 0.00012 21.7 0.1 0.037 13.6 0.0 2.6 3 0 0 3 3 2 1 AAA domain Sigma54_activat PF00158.21 ESL10994.1 - 0.0006 19.3 0.0 0.64 9.4 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.1 ESL10994.1 - 0.00067 19.6 0.2 0.098 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 ESL10994.1 - 0.00074 19.1 0.1 0.36 10.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 PhoH PF02562.11 ESL10994.1 - 0.00083 18.6 0.0 0.35 10.0 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein KTI12 PF08433.5 ESL10994.1 - 0.0017 17.6 0.1 1.5 7.9 0.0 2.5 3 0 0 3 3 2 2 Chromatin associated protein KTI12 AAA_30 PF13604.1 ESL10994.1 - 0.0031 17.1 0.1 2.9 7.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain PPV_E1_C PF00519.12 ESL10994.1 - 0.0034 16.0 0.0 1.7 7.1 0.0 2.1 2 0 0 2 2 2 2 Papillomavirus helicase T2SE PF00437.15 ESL10994.1 - 0.0045 15.9 0.0 0.082 11.7 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.22 ESL10994.1 - 0.0063 16.8 0.0 6.3 7.0 0.0 2.7 2 0 0 2 2 2 0 ABC transporter Sigma54_activ_2 PF14532.1 ESL10994.1 - 0.0063 16.5 0.0 3.8 7.5 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.10 ESL10994.1 - 0.0083 15.9 0.0 0.7 9.6 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.7 ESL10994.1 - 0.0089 15.1 0.1 2.9 6.9 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_14 PF13173.1 ESL10994.1 - 0.011 15.6 0.0 0.95 9.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.6 ESL10994.1 - 0.014 14.9 0.0 0.69 9.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zot PF05707.7 ESL10994.1 - 0.017 14.5 0.0 2 7.8 0.0 2.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Arch_ATPase PF01637.13 ESL10994.1 - 0.02 14.6 0.0 0.11 12.1 0.0 2.2 3 0 0 3 3 2 0 Archaeal ATPase Parvo_NS1 PF01057.12 ESL10994.1 - 0.032 13.0 0.0 3.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Adeno_IVa2 PF02456.10 ESL10994.1 - 0.056 12.0 0.0 0.086 11.4 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein KAP_NTPase PF07693.9 ESL10994.1 - 0.087 11.7 0.0 0.21 10.5 0.0 1.7 1 0 0 1 1 1 0 KAP family P-loop domain cobW PF02492.14 ESL10994.1 - 0.096 12.1 0.3 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 ESL10994.1 - 0.43 10.2 1.7 35 4.0 0.0 3.0 3 0 0 3 3 3 0 NTPase Met_10 PF02475.11 ESL10995.1 - 9e-47 159.2 0.2 4.4e-32 111.3 0.0 2.3 2 0 0 2 2 2 2 Met-10+ like-protein Methyltransf_26 PF13659.1 ESL10995.1 - 0.00057 19.8 0.2 0.0018 18.2 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESL10995.1 - 0.0032 16.6 0.0 0.0054 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TRM PF02005.11 ESL10995.1 - 0.029 13.3 0.0 0.054 12.4 0.0 1.4 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase UPF0020 PF01170.13 ESL10995.1 - 0.054 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF3392 PF11872.3 ESL10997.1 - 0.51 10.3 9.3 0.99 9.4 0.1 4.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3392) EMG1 PF03587.9 ESL10998.1 - 2.6e-41 141.1 0.0 3.2e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase EMP24_GP25L PF01105.19 ESL10999.1 - 2.1e-42 144.9 0.0 2.3e-42 144.7 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ABC_ATPase PF09818.4 ESL11000.1 - 4.3e-170 566.1 0.0 5.5e-170 565.7 0.0 1.0 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.1 ESL11000.1 - 0.037 14.3 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain PAC2 PF09754.4 ESL11000.1 - 0.058 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 PAC2 family AAA_25 PF13481.1 ESL11000.1 - 0.07 12.5 0.3 0.31 10.4 0.2 2.0 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESL11000.1 - 0.18 12.0 0.1 5.3 7.3 0.1 2.3 1 1 0 1 1 1 0 ABC transporter PPR_3 PF13812.1 ESL11001.1 - 0.038 14.2 0.2 0.24 11.7 0.0 2.5 2 0 0 2 2 2 0 Pentatricopeptide repeat domain FWWh PF14922.1 ESL11003.1 - 3.2e-23 81.9 1.1 2.6e-20 72.5 0.8 2.4 2 0 0 2 2 2 2 Protein of unknown function Utp12 PF04003.7 ESL11004.1 - 0.0051 16.6 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Methyltransf_32 PF13679.1 ESL11004.1 - 0.036 13.7 0.1 0.1 12.2 0.1 1.8 1 0 0 1 1 1 0 Methyltransferase domain UPF0697 PF15117.1 ESL11004.1 - 1.5 8.6 4.3 20 5.0 0.2 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0697 PSS PF03034.10 ESL11005.1 - 8.8e-108 359.9 6.6 1.3e-107 359.3 4.6 1.3 1 0 0 1 1 1 1 Phosphatidyl serine synthase DUF4131 PF13567.1 ESL11005.1 - 1.7 8.0 17.6 0.52 9.7 2.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) NfeD PF01957.13 ESL11005.1 - 7.6 6.6 18.8 0.96 9.5 1.0 3.8 4 1 1 5 5 5 0 NfeD-like C-terminal, partner-binding Apc3 PF12895.2 ESL11006.1 - 2e-05 24.6 0.2 0.0035 17.4 0.1 3.3 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESL11006.1 - 0.0061 16.2 0.2 49 4.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11006.1 - 0.03 14.9 0.1 0.91 10.3 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11006.1 - 0.04 14.2 0.5 33 4.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11006.1 - 0.047 13.6 0.4 23 5.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat CTP_transf_1 PF01148.15 ESL11007.1 - 8.5e-32 110.8 22.5 1.5e-30 106.6 15.6 2.4 1 1 0 1 1 1 1 Cytidylyltransferase family Benyvirus_P25 PF05744.6 ESL11007.1 - 0.095 12.0 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Benyvirus P25/P26 protein Git3_C PF11970.3 ESL11007.1 - 0.32 10.7 3.3 7.2 6.4 0.1 3.3 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term Peptidase_M28 PF04389.12 ESL11008.1 - 0.1 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 DUF982 PF06169.7 ESL11008.1 - 0.3 10.8 6.6 6.6 6.5 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF982) Thioredoxin PF00085.15 ESL11009.1 - 8.6e-12 44.6 0.0 5.9e-07 29.1 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 ESL11009.1 - 0.0012 19.0 0.0 0.0079 16.3 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain TrbC_Ftype PF09673.5 ESL11009.1 - 0.04 13.5 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein NIF3 PF01784.13 ESL11010.1 - 4.6e-64 216.2 0.0 5.5e-64 216.0 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Pkinase PF00069.20 ESL11013.1 - 2.9e-07 29.9 0.0 4.1e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11013.1 - 2.8e-05 23.3 0.0 4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NUDIX PF00293.23 ESL11014.1 - 2.6e-06 27.0 0.0 8.4e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain adh_short PF00106.20 ESL11015.1 - 1.3e-06 28.4 5.1 7.1e-06 26.0 3.5 1.9 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 ESL11015.1 - 0.0038 16.7 0.1 0.006 16.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Asparaginase PF00710.15 ESL11016.1 - 3.5e-64 216.6 0.0 2.4e-59 200.7 0.0 2.0 2 0 0 2 2 2 2 Asparaginase SNARE PF05739.14 ESL11017.1 - 8.5e-07 28.5 0.3 1.5e-06 27.7 0.2 1.4 1 0 0 1 1 1 1 SNARE domain Methyltransf_PK PF05891.7 ESL11017.1 - 0.0058 15.9 0.1 0.008 15.5 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase DUF3987 PF13148.1 ESL11017.1 - 0.069 11.7 1.5 0.087 11.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) CHCH PF06747.8 ESL11020.1 - 4.9e-06 26.3 1.0 8.3e-06 25.5 0.7 1.4 1 0 0 1 1 1 1 CHCH domain COX17 PF05051.8 ESL11020.1 - 0.012 15.6 2.2 0.12 12.4 0.3 2.3 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.5 ESL11020.1 - 0.016 14.9 1.8 0.042 13.6 1.3 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.12 ESL11020.1 - 0.023 14.7 0.4 0.047 13.7 0.3 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 ESL11020.1 - 0.081 12.9 1.1 0.19 11.7 0.8 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 DUF1903 PF08991.5 ESL11020.1 - 5.9 7.1 6.5 1.3 9.2 2.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1903) Metallophos PF00149.23 ESL11021.1 - 5e-07 29.3 0.6 1.2e-06 28.0 0.6 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL11021.1 - 0.0032 17.3 0.0 0.019 14.7 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain HAD_2 PF13419.1 ESL11022.1 - 4.5e-19 69.3 0.0 5.7e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NIF PF03031.13 ESL11022.1 - 0.00015 21.4 0.1 0.0026 17.4 0.1 2.2 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.21 ESL11022.1 - 0.005 17.2 0.0 0.074 13.4 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Heme_oxygenase PF01126.15 ESL11022.1 - 0.08 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Heme oxygenase REGB_T4 PF10715.4 ESL11022.1 - 0.089 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Endoribonuclease RegB T4-bacteriophage encoded SNARE PF05739.14 ESL11023.1 - 1.2e-10 40.9 6.7 1.2e-10 40.9 4.6 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.1 ESL11023.1 - 1.9e-10 40.6 0.7 1.9e-10 40.6 0.5 2.3 2 1 0 2 2 2 1 Syntaxin-like protein MCPsignal PF00015.16 ESL11023.1 - 0.001 18.6 3.1 0.032 13.7 0.8 2.3 2 0 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Spc7 PF08317.6 ESL11023.1 - 0.002 16.8 0.2 0.002 16.8 0.1 1.8 2 0 0 2 2 2 1 Spc7 kinetochore protein Synaptobrevin PF00957.16 ESL11023.1 - 0.22 11.1 0.1 0.22 11.1 0.1 2.5 3 0 0 3 3 3 0 Synaptobrevin DUF1664 PF07889.7 ESL11023.1 - 0.34 10.7 2.9 3.3 7.5 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Metallophos PF00149.23 ESL11025.1 - 2e-12 46.9 0.2 7.9e-12 44.9 0.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Apolipoprotein PF01442.13 ESL11027.1 - 0.00054 19.5 0.6 0.00091 18.7 0.4 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain APG17 PF04108.7 ESL11027.1 - 0.0034 16.2 2.3 0.0046 15.8 1.6 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 Bacillus_HBL PF05791.6 ESL11027.1 - 0.005 16.2 2.1 0.018 14.4 0.1 2.0 1 1 1 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) Myosin_tail_1 PF01576.14 ESL11027.1 - 0.0065 14.2 1.2 0.0083 13.9 0.8 1.0 1 0 0 1 1 1 1 Myosin tail NPV_P10 PF05531.7 ESL11027.1 - 0.038 14.2 1.9 7.7 6.8 0.4 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Mer2 PF09074.5 ESL11027.1 - 0.038 13.9 2.0 0.1 12.5 1.3 1.8 1 1 0 1 1 1 0 Mer2 DUF2681 PF10883.3 ESL11027.1 - 0.21 11.8 2.0 2.8 8.1 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Nsp1_C PF05064.8 ESL11027.1 - 0.31 10.7 2.8 0.79 9.3 2.0 1.7 1 1 0 1 1 1 0 Nsp1-like C-terminal region DUF1127 PF06568.6 ESL11028.1 - 0.021 14.2 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) SIN1 PF05422.7 ESL11029.1 - 0.019 13.4 0.0 0.03 12.8 0.0 1.3 1 0 0 1 1 1 0 Stress-activated map kinase interacting protein 1 (SIN1) Myosin_TH1 PF06017.8 ESL11029.1 - 0.038 13.2 0.0 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 Myosin tail MIP PF00230.15 ESL11030.1 - 4.1e-31 108.2 21.1 4.1e-30 104.9 14.6 2.0 1 1 0 1 1 1 1 Major intrinsic protein PGI PF00342.14 ESL11032.1 - 5.4e-229 760.5 0.1 6.3e-229 760.3 0.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Urease_beta PF00699.15 ESL11032.1 - 0.083 12.7 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Urease beta subunit DUF2420 PF10336.4 ESL11036.1 - 0.13 11.8 0.6 0.28 10.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2420) FtsK_SpoIIIE_N PF12538.3 ESL11037.1 - 0.078 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 DNA transporter NDUFA12 PF05071.11 ESL11037.1 - 0.087 13.2 0.2 11 6.5 0.0 2.3 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 zinc-ribbons_6 PF07191.7 ESL11037.1 - 0.13 12.0 0.3 1 9.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbons Not3 PF04065.10 ESL11037.1 - 0.16 11.2 2.4 1.3 8.2 0.3 2.1 1 1 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component DUF2046 PF09755.4 ESL11038.1 - 7.7e-05 21.7 8.1 0.00016 20.6 5.6 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) UBN_AB PF14075.1 ESL11038.1 - 0.0038 16.9 7.1 0.014 15.0 1.0 2.9 3 0 0 3 3 3 1 Ubinuclein conserved middle domain B2 PF11473.3 ESL11038.1 - 0.053 13.1 0.1 0.29 10.7 0.0 2.3 1 1 1 2 2 2 0 RNA binding protein B2 UBACT PF02134.16 ESL11038.1 - 0.09 12.3 0.2 8.2 6.0 0.0 2.5 2 0 0 2 2 2 0 Repeat in ubiquitin-activating (UBA) protein Tenui_NCP PF04876.7 ESL11038.1 - 0.12 11.9 0.5 2.8 7.4 0.0 2.9 2 1 1 3 3 3 0 Tenuivirus major non-capsid protein DUF1620 PF07774.8 ESL11039.1 - 1.4e-45 155.1 0.0 2.3e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 ESL11039.1 - 1.2e-08 34.7 1.7 0.00018 21.0 0.2 3.1 2 1 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 ESL11039.1 - 3.7e-05 23.0 0.3 0.65 9.6 0.0 5.0 5 0 0 5 5 5 1 PQQ enzyme repeat YscW PF09619.5 ESL11039.1 - 0.091 12.4 0.2 7.9 6.2 0.0 3.6 3 0 0 3 3 3 0 Type III secretion system lipoprotein chaperone (YscW) DYW_deaminase PF14432.1 ESL11040.1 - 0.012 15.6 0.1 0.049 13.6 0.0 2.0 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases RNase_H PF00075.19 ESL11041.1 - 1.6e-26 93.1 0.0 3.9e-25 88.7 0.0 2.2 1 1 0 1 1 1 1 RNase H Cauli_VI PF01693.11 ESL11041.1 - 7.5e-18 64.2 0.8 1.5e-17 63.3 0.6 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin Phage_cap_P2 PF05125.7 ESL11041.1 - 0.052 12.4 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein, P2 family EF-hand_7 PF13499.1 ESL11042.1 - 0.00029 20.9 0.2 0.013 15.6 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL11042.1 - 0.00056 19.0 0.1 0.069 12.4 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 ESL11042.1 - 0.0012 18.5 0.2 0.033 14.0 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 ESL11042.1 - 0.058 13.0 0.3 3.3 7.3 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain pair PIH1 PF08190.7 ESL11043.1 - 4.3e-39 134.8 2.3 9.5e-28 97.5 0.0 4.2 4 0 0 4 4 4 4 pre-RNA processing PIH1/Nop17 ketoacyl-synt PF00109.21 ESL11044.1 - 1.3e-36 126.3 0.6 2.5e-36 125.4 0.4 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 ESL11044.1 - 2.3e-27 95.1 1.3 9.8e-27 93.1 0.5 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 ESL11044.1 - 0.017 14.1 0.2 0.03 13.3 0.1 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain NIP_1 PF08995.5 ESL11045.1 - 0.011 15.8 2.0 0.018 15.1 0.7 1.8 2 0 0 2 2 2 0 Necrosis inducing protein-1 Suf PF05843.9 ESL11045.1 - 0.027 14.1 0.0 0.14 11.8 0.0 2.1 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) TPR_11 PF13414.1 ESL11046.1 - 3.1e-28 97.2 20.9 1.6e-08 34.0 0.4 6.2 5 1 1 6 6 6 4 TPR repeat TPR_2 PF07719.12 ESL11046.1 - 1.6e-21 74.4 20.9 0.0021 17.8 0.7 9.8 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11046.1 - 1.1e-19 69.1 15.1 0.0015 18.0 0.2 8.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESL11046.1 - 1.7e-16 60.4 18.2 0.00011 22.8 2.2 6.9 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11046.1 - 1.5e-15 57.2 8.2 0.0013 19.0 0.0 6.8 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL11046.1 - 2.1e-14 53.2 7.0 5.6e-06 26.2 0.0 6.7 4 2 4 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESL11046.1 - 7.6e-11 40.9 12.8 0.36 10.7 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat Apc3 PF12895.2 ESL11046.1 - 2.8e-09 36.9 17.1 0.0018 18.3 1.4 4.7 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESL11046.1 - 1.8e-08 33.9 1.6 0.56 10.5 0.0 6.6 7 1 1 8 8 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL11046.1 - 4e-08 32.4 4.9 0.59 10.0 0.0 6.9 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11046.1 - 6.8e-07 29.3 17.2 0.28 11.9 1.2 7.8 7 3 2 9 9 7 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESL11046.1 - 0.00014 21.6 4.0 2.1 8.3 0.1 4.9 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat DUF3856 PF12968.2 ESL11046.1 - 0.0012 18.6 1.4 0.0065 16.3 0.6 2.7 3 0 0 3 3 2 1 Domain of Unknown Function (DUF3856) TPR_9 PF13371.1 ESL11046.1 - 0.0039 16.9 15.3 3.3 7.6 0.1 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL11046.1 - 0.074 13.5 18.8 2.2 8.8 0.0 6.7 8 0 0 8 8 8 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESL11046.1 - 0.09 13.0 2.7 0.59 10.3 0.2 2.6 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_10 PF13374.1 ESL11046.1 - 0.35 10.8 14.3 2 8.4 0.0 6.4 7 1 1 8 8 8 0 Tetratricopeptide repeat AAA_2 PF07724.9 ESL11047.1 - 1.5e-52 177.9 0.0 1e-49 168.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESL11047.1 - 7.5e-24 84.4 0.0 1.6e-13 51.0 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 ESL11047.1 - 1.1e-20 73.2 0.8 3.8e-20 71.5 0.0 2.4 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 ESL11047.1 - 4.4e-17 62.1 0.0 1.8e-11 43.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL11047.1 - 1.3e-12 48.0 1.7 0.00046 20.2 0.0 4.7 2 2 3 5 5 5 3 AAA ATPase domain AAA_22 PF13401.1 ESL11047.1 - 5.6e-11 42.7 1.3 0.00014 21.9 0.0 4.5 3 2 0 4 4 4 2 AAA domain AAA_17 PF13207.1 ESL11047.1 - 3.7e-07 30.9 6.0 0.0024 18.6 0.0 3.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESL11047.1 - 3.5e-06 27.3 3.5 0.055 13.7 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_14 PF13173.1 ESL11047.1 - 5.6e-06 26.2 0.0 0.17 11.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 ESL11047.1 - 6.6e-05 22.4 0.0 0.058 12.8 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain RNA_helicase PF00910.17 ESL11047.1 - 7.2e-05 22.9 0.0 0.58 10.3 0.0 2.9 3 0 0 3 3 2 2 RNA helicase AAA_25 PF13481.1 ESL11047.1 - 0.0001 21.7 0.0 0.81 9.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.7 ESL11047.1 - 0.00011 21.2 1.1 0.11 11.5 0.0 3.2 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 ESL11047.1 - 0.00016 21.1 0.0 0.081 12.3 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein DNA_pol3_delta2 PF13177.1 ESL11047.1 - 0.00017 21.2 0.0 0.0052 16.4 0.0 3.1 3 1 0 3 3 2 1 DNA polymerase III, delta subunit AAA_3 PF07726.6 ESL11047.1 - 0.00031 20.3 0.0 0.53 9.9 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.10 ESL11047.1 - 0.00051 19.9 0.6 1.3 8.8 0.0 3.9 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESL11047.1 - 0.00078 19.1 0.0 0.16 11.7 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 ESL11047.1 - 0.0013 18.7 0.7 1.2 9.1 0.0 3.5 3 1 0 3 3 3 1 AAA domain NACHT PF05729.7 ESL11047.1 - 0.0014 18.3 0.0 0.044 13.4 0.0 2.7 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.16 ESL11047.1 - 0.0023 17.1 0.0 3.6 6.6 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI MobB PF03205.9 ESL11047.1 - 0.0025 17.5 0.0 0.41 10.3 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 ESL11047.1 - 0.0043 16.1 0.8 0.32 10.0 0.0 3.2 3 1 0 3 3 2 1 Zeta toxin AAA_33 PF13671.1 ESL11047.1 - 0.0054 16.6 0.6 3.4 7.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain DEAD PF00270.24 ESL11047.1 - 0.0085 15.5 0.1 9.1 5.7 0.0 3.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase DUF258 PF03193.11 ESL11047.1 - 0.0097 15.1 0.0 1.8 7.7 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_24 PF13479.1 ESL11047.1 - 0.012 15.2 0.2 1.5 8.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.10 ESL11047.1 - 0.012 15.3 0.0 3.3 7.3 0.0 3.0 3 0 0 3 3 2 0 NTPase SRP54 PF00448.17 ESL11047.1 - 0.014 14.8 0.0 0.72 9.2 0.0 2.8 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain Ribosomal_S7 PF00177.16 ESL11047.1 - 0.024 14.2 0.0 0.071 12.6 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e Miro PF08477.8 ESL11047.1 - 0.024 15.1 0.0 0.37 11.3 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein DUF815 PF05673.8 ESL11047.1 - 0.024 13.5 0.2 0.28 10.0 0.0 2.7 4 0 0 4 4 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 ESL11047.1 - 0.037 14.3 0.1 16 5.8 0.0 3.2 3 0 0 3 3 3 0 ABC transporter AAA_29 PF13555.1 ESL11047.1 - 0.037 13.5 0.0 5 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Torsin PF06309.6 ESL11047.1 - 0.038 13.8 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 1 0 Torsin His_kinase PF06580.8 ESL11047.1 - 0.049 13.5 0.7 1.8 8.5 0.1 2.7 2 0 0 2 2 2 0 Histidine kinase DUF4404 PF14357.1 ESL11047.1 - 0.056 13.8 3.0 2.3 8.6 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) UPF0079 PF02367.12 ESL11047.1 - 0.071 12.7 0.0 14 5.3 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 V_ATPase_I PF01496.14 ESL11047.1 - 0.08 10.7 3.7 0.11 10.2 2.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MMR_HSR1 PF01926.18 ESL11047.1 - 0.09 12.7 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_10 PF12846.2 ESL11047.1 - 0.094 12.1 2.0 15 4.9 0.0 4.1 3 2 0 4 4 4 0 AAA-like domain GrpE PF01025.14 ESL11047.1 - 0.1 12.1 5.2 0.3 10.6 3.6 1.9 1 0 0 1 1 1 0 GrpE ATP_bind_1 PF03029.12 ESL11047.1 - 0.11 11.9 0.0 3.7 7.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IncA PF04156.9 ESL11047.1 - 0.47 10.0 9.0 0.94 9.0 6.2 1.4 1 0 0 1 1 1 0 IncA protein 4HB_MCP_1 PF12729.2 ESL11047.1 - 0.67 9.2 4.8 1.2 8.4 3.4 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction APG6 PF04111.7 ESL11047.1 - 1.3 7.9 7.6 2.2 7.2 5.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Atg14 PF10186.4 ESL11047.1 - 4.7 6.0 6.5 9.6 5.0 4.5 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_23 PF13476.1 ESL11047.1 - 4.9 7.4 13.3 55 3.9 0.0 3.4 2 1 0 2 2 2 0 AAA domain TPR_11 PF13414.1 ESL11048.1 - 2.9e-21 74.8 19.3 7.4e-09 35.1 0.1 5.5 4 1 1 5 5 5 5 TPR repeat DnaJ PF00226.26 ESL11048.1 - 3.7e-21 74.6 4.0 3.7e-21 74.6 2.8 2.7 3 0 0 3 3 3 1 DnaJ domain TPR_19 PF14559.1 ESL11048.1 - 2.1e-16 59.9 26.4 9.4e-05 22.6 4.3 6.2 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11048.1 - 9.2e-14 50.1 24.8 0.032 14.1 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESL11048.1 - 3.7e-12 46.5 35.3 0.0042 17.7 5.6 6.5 4 3 3 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11048.1 - 2e-10 40.3 27.8 0.022 15.3 2.4 8.1 4 3 5 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESL11048.1 - 8.7e-08 31.9 21.4 0.00097 18.9 0.7 4.8 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11048.1 - 2e-06 27.1 15.2 0.49 10.0 0.0 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESL11048.1 - 2.3e-06 27.3 10.9 1.2 9.4 0.2 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL11048.1 - 0.00054 19.5 3.4 1.7 8.6 0.3 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL11048.1 - 0.00091 19.5 13.1 0.075 13.5 0.8 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESL11048.1 - 0.001 19.3 1.4 0.001 19.3 1.0 3.4 4 1 1 5 5 5 1 Alkyl sulfatase dimerisation Fis1_TPR_C PF14853.1 ESL11048.1 - 0.0064 16.3 12.4 0.3 10.9 0.1 5.1 3 2 2 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 ESL11048.1 - 0.018 15.1 13.5 3.5 7.8 1.8 4.7 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL11048.1 - 0.091 12.5 4.2 2.5 8.0 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESL11048.1 - 0.5 10.3 24.5 0.99 9.3 0.0 6.0 4 3 3 7 7 7 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL11049.1 - 5.6e-59 199.4 0.0 1.1e-58 198.4 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11049.1 - 1.3e-38 132.5 0.0 1.8e-38 132.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11049.1 - 5.1e-07 28.9 0.0 7.5e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESL11049.1 - 0.0063 15.6 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ku PF02735.11 ESL11050.1 - 2.3e-17 63.0 0.0 3.5e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain DUF1353 PF07087.6 ESL11050.1 - 0.13 11.7 0.1 0.48 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1353) NMT PF01233.14 ESL11051.1 - 6.7e-60 201.3 0.1 2.4e-33 115.0 0.0 2.3 2 0 0 2 2 2 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.10 ESL11051.1 - 2.3e-58 196.7 2.6 3.2e-38 131.0 0.8 2.4 3 0 0 3 3 3 2 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Cyclin_N PF00134.18 ESL11052.1 - 0.00081 18.9 0.2 0.012 15.1 0.0 2.4 2 1 0 2 2 2 1 Cyclin, N-terminal domain NHase_alpha PF02979.11 ESL11052.1 - 0.16 11.2 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain WD40 PF00400.27 ESL11053.1 - 1.2e-21 75.7 16.0 1.4e-06 27.9 0.0 5.7 6 0 0 6 6 6 5 WD domain, G-beta repeat DPPIV_N PF00930.16 ESL11053.1 - 0.13 10.8 0.4 7 5.1 0.0 2.1 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region TPR_11 PF13414.1 ESL11055.1 - 1.8e-05 24.2 7.4 0.002 17.7 1.0 2.7 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.1 ESL11055.1 - 0.0018 18.9 0.3 0.0046 17.5 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11055.1 - 0.0071 16.1 5.2 1.4 9.0 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11055.1 - 0.0073 15.8 2.4 0.58 9.8 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESL11055.1 - 0.049 13.8 1.9 0.075 13.2 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 ESL11055.1 - 0.11 12.5 1.8 0.29 11.2 1.2 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_1 PF00036.27 ESL11056.1 - 3.8e-12 44.5 3.6 1.2e-06 27.3 0.0 3.0 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESL11056.1 - 2.2e-10 39.5 1.1 5.8e-05 22.6 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESL11056.1 - 3.1e-08 33.6 1.3 1.1e-07 31.8 0.1 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL11056.1 - 2.9e-06 26.8 6.1 7e-05 22.3 0.2 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 ESL11056.1 - 5.8e-06 25.4 5.1 9.7e-05 21.5 0.0 3.5 3 1 0 3 3 3 1 EF hand EF-hand_10 PF14788.1 ESL11056.1 - 0.02 14.5 0.0 0.94 9.1 0.0 2.1 2 0 0 2 2 2 0 EF hand DUF4345 PF14248.1 ESL11058.1 - 0.13 11.7 2.2 0.16 11.4 1.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4345) SET PF00856.23 ESL11059.1 - 5.9e-12 46.1 2.4 4.3e-10 40.1 0.1 2.9 2 1 0 2 2 2 2 SET domain zf-Mss51 PF13824.1 ESL11059.1 - 2e-05 24.3 3.0 8.2e-05 22.3 2.1 2.0 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.13 ESL11059.1 - 0.00031 20.5 2.9 0.00031 20.5 2.0 3.3 2 1 0 2 2 2 1 MYND finger YedD PF13987.1 ESL11059.1 - 0.027 14.0 0.1 0.053 13.0 0.1 1.4 1 0 0 1 1 1 0 YedD-like protein DUF423 PF04241.10 ESL11060.1 - 2.9e-21 75.1 3.5 2.9e-21 75.1 2.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF423) NfeD PF01957.13 ESL11060.1 - 0.082 13.0 0.4 0.082 13.0 0.3 2.1 2 1 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF2516 PF10724.4 ESL11060.1 - 0.28 11.1 2.1 0.89 9.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) DUF1761 PF08570.5 ESL11060.1 - 0.61 10.1 6.2 1.7 8.6 4.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1761) Nol1_Nop2_Fmu PF01189.12 ESL11061.1 - 8.5e-13 48.3 0.0 9e-11 41.6 0.0 2.2 2 0 0 2 2 2 2 NOL1/NOP2/sun family HAP1_N PF04849.8 ESL11062.1 - 2.3e-05 23.5 7.5 3.7e-05 22.8 5.2 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region OmpH PF03938.9 ESL11062.1 - 0.3 11.0 6.1 0.65 9.9 4.2 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF972 PF06156.8 ESL11062.1 - 1.5 9.2 6.7 3.9 7.8 4.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF972) WD40 PF00400.27 ESL11064.1 - 4.9e-28 95.9 15.8 1.4e-08 34.2 1.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat PRP4 PF08799.6 ESL11064.1 - 1.3e-06 27.5 0.6 2.7e-06 26.5 0.1 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like MT PF12777.2 ESL11065.1 - 0.00017 20.5 0.0 0.00025 19.9 0.0 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor MerR_1 PF13411.1 ESL11065.1 - 0.029 14.1 0.2 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 MerR HTH family regulatory protein ApoLp-III PF07464.6 ESL11065.1 - 0.046 13.7 0.5 0.079 12.9 0.3 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) COX16 PF14138.1 ESL11065.1 - 0.071 13.2 0.3 0.23 11.6 0.2 1.8 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 DUF4404 PF14357.1 ESL11065.1 - 0.34 11.3 2.4 0.55 10.6 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) HEAT PF02985.17 ESL11068.1 - 1.3e-05 24.8 6.6 0.86 9.8 0.0 7.1 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.1 ESL11068.1 - 0.0066 16.9 8.9 0.58 10.7 0.0 6.6 6 3 4 10 10 10 1 HEAT-like repeat DUF1546 PF07571.8 ESL11068.1 - 0.056 13.5 0.0 36 4.5 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1546) IBN_N PF03810.14 ESL11068.1 - 0.17 11.8 0.8 2.4 8.1 0.0 3.2 4 0 0 4 4 4 0 Importin-beta N-terminal domain DUF3648 PF12364.3 ESL11069.1 - 3.9e-15 56.0 0.7 8.6e-15 54.9 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3648) NeA_P2 PF12312.3 ESL11069.1 - 0.052 12.7 0.9 0.63 9.2 0.6 2.1 2 0 0 2 2 2 0 Nepovirus subgroup A polyprotein Tubulin PF00091.20 ESL11070.1 - 2.8e-71 239.7 0.0 4.5e-71 239.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESL11070.1 - 4.4e-25 88.1 0.0 8.5e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESL11070.1 - 0.00043 20.3 0.0 0.00082 19.4 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESL11070.1 - 0.037 13.5 0.0 0.071 12.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.1 ESL11070.1 - 0.066 12.1 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Mt_ATP-synt_D PF05873.7 ESL11071.1 - 0.046 13.3 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Cpn60_TCP1 PF00118.19 ESL11072.1 - 0.14 10.7 0.0 0.18 10.3 0.0 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family Ribosomal_L13e PF01294.13 ESL11073.1 - 3.6e-52 176.4 7.2 3.6e-52 176.4 5.0 1.5 1 1 1 2 2 2 1 Ribosomal protein L13e IFRD PF05004.8 ESL11074.1 - 0.045 12.8 0.0 0.31 10.0 0.0 1.9 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) Ribosomal_L18e PF00828.14 ESL11075.1 - 3.2e-19 69.5 0.1 3.2e-19 69.5 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 Sec63 PF02889.11 ESL11076.1 - 6.8e-154 511.7 0.1 2.4e-87 293.0 0.2 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 ESL11076.1 - 1.6e-52 177.4 0.1 3.7e-28 98.1 0.2 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 ESL11076.1 - 5.5e-21 75.2 0.0 1.6e-13 50.9 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESL11076.1 - 4.7e-18 64.8 0.0 2.2e-08 33.8 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESL11076.1 - 5.3e-07 29.8 0.0 0.0024 18.0 0.0 3.8 3 2 0 3 3 3 2 AAA domain T2SE PF00437.15 ESL11076.1 - 1.9e-05 23.7 0.0 0.013 14.4 0.0 2.9 3 0 0 3 3 3 2 Type II/IV secretion system protein PhoH PF02562.11 ESL11076.1 - 0.0014 17.9 0.1 1.1 8.4 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_10 PF12846.2 ESL11076.1 - 0.0032 16.9 1.3 4.8 6.5 0.0 4.1 4 1 0 5 5 5 1 AAA-like domain AAA PF00004.24 ESL11076.1 - 0.089 12.9 1.4 4.9 7.3 0.1 3.9 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Trichoplein PF13868.1 ESL11077.1 - 4.9e-66 222.5 151.9 4.9e-66 222.5 105.3 2.0 2 0 0 2 2 2 1 Tumour suppressor, Mitostatin RRM_1 PF00076.17 ESL11078.1 - 5.4e-07 29.1 0.0 1.6e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL11078.1 - 0.011 15.6 0.0 0.043 13.7 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NDK PF00334.14 ESL11079.1 - 3.3e-55 185.5 0.0 3.9e-55 185.3 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase tRNA_bind PF01588.15 ESL11081.1 - 6.8e-26 89.9 0.0 1.3e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain PID_2 PF14719.1 ESL11082.1 - 4.6 6.8 6.8 1.2 8.7 1.4 2.1 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Peptidase_M8 PF01457.11 ESL11083.1 - 2.7e-50 171.2 0.0 3.4e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin SprT-like PF10263.4 ESL11083.1 - 0.017 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_M57 PF12388.3 ESL11083.1 - 0.048 12.9 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.1 ESL11083.1 - 0.12 12.2 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Astacin PF01400.19 ESL11083.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) EF-hand_6 PF13405.1 ESL11085.1 - 1.1e-06 28.0 0.4 0.00075 19.1 0.0 3.3 2 1 1 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 ESL11085.1 - 3.9e-06 26.9 0.3 0.00011 22.2 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL11085.1 - 9.3e-06 24.5 0.1 0.007 15.6 0.0 3.3 2 1 1 3 3 3 2 EF hand EF-hand_8 PF13833.1 ESL11085.1 - 0.0011 18.5 0.2 0.7 9.5 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 ESL11085.1 - 0.0027 17.5 0.0 0.15 12.0 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain ICMT PF04140.9 ESL11086.1 - 8.2e-18 64.4 1.4 8.2e-18 64.4 1.0 1.9 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ESL11086.1 - 7.3e-06 26.0 2.4 7.3e-06 26.0 1.7 2.9 2 1 1 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.7 ESL11086.1 - 0.0098 15.2 0.3 0.018 14.3 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PAP2 PF01569.16 ESL11087.1 - 9.8e-20 70.5 3.5 9.8e-20 70.5 2.4 2.3 3 0 0 3 3 3 1 PAP2 superfamily Sad1_UNC PF07738.8 ESL11088.1 - 1.1e-22 80.3 0.0 1.6e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Snapin_Pallidin PF14712.1 ESL11088.1 - 0.017 15.4 1.6 0.034 14.4 1.1 1.4 1 0 0 1 1 1 0 Snapin/Pallidin NUT_C PF12882.2 ESL11089.1 - 0.11 12.0 0.7 0.19 11.3 0.5 1.3 1 0 0 1 1 1 0 NUT protein C terminal Gcd10p PF04189.8 ESL11090.1 - 3.6e-67 226.6 0.0 4.7e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family Pkinase PF00069.20 ESL11092.1 - 3.8e-56 190.1 0.1 5.2e-56 189.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain MORN PF02493.15 ESL11092.1 - 1.4e-45 150.3 41.7 1.8e-08 33.6 0.4 9.4 9 0 0 9 9 9 8 MORN repeat Pkinase_Tyr PF07714.12 ESL11092.1 - 9.9e-42 142.7 0.0 1.5e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11092.1 - 0.00021 20.3 0.1 0.00042 19.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Tom37 PF10568.4 ESL11093.1 - 7.4e-07 29.3 0.0 1.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.1 ESL11093.1 - 0.00016 21.5 0.0 0.00037 20.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESL11093.1 - 0.00017 21.9 0.0 0.0003 21.1 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain LRR_4 PF12799.2 ESL11094.1 - 9.2e-20 69.8 3.3 2.9e-08 33.1 0.5 3.8 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL11094.1 - 7.7e-11 41.5 7.9 3.3e-06 26.7 1.7 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.1 ESL11094.1 - 9.3e-08 31.3 8.5 0.52 10.5 0.1 5.3 4 1 1 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.28 ESL11094.1 - 2.4e-05 23.7 9.1 0.55 10.4 0.1 5.5 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.1 ESL11094.1 - 2.9e-05 23.7 0.0 0.033 13.7 0.1 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 ESL11094.1 - 0.0003 20.4 9.1 0.087 13.0 0.2 5.0 5 0 0 5 5 5 1 Leucine rich repeat Npa1 PF11707.3 ESL11096.1 - 3.9e-07 29.4 0.0 9.6e-07 28.1 0.0 1.7 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Epimerase PF01370.16 ESL11097.1 - 2.7e-66 223.3 0.0 3.5e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESL11097.1 - 2.3e-06 26.6 0.0 3.7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase_Csub PF13950.1 ESL11097.1 - 3.1e-05 23.8 0.0 7.4e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Polysacc_synt_2 PF02719.10 ESL11097.1 - 0.0088 14.9 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein zf-UBP PF02148.14 ESL11097.1 - 0.056 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein NAD_binding_10 PF13460.1 ESL11097.1 - 0.066 13.2 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding HMG_CoA_synt_N PF01154.12 ESL11098.1 - 5.5e-11 42.3 0.0 9.3e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.5 ESL11098.1 - 2.1e-05 24.1 0.4 0.046 13.1 0.0 2.2 2 0 0 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III PF08545.5 ESL11098.1 - 0.00052 19.6 0.8 0.0011 18.5 0.6 1.5 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1726 PF08351.6 ESL11098.1 - 0.02 14.5 0.0 0.05 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) UPRTase PF14681.1 ESL11100.1 - 1.4e-68 230.1 0.0 1.7e-68 229.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 ESL11100.1 - 2e-06 27.5 0.0 3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain AAA_23 PF13476.1 ESL11102.1 - 0.38 11.0 7.9 0.059 13.6 1.9 2.0 2 0 0 2 2 2 0 AAA domain MADF_DNA_bdg PF10545.4 ESL11102.1 - 3.5 7.8 8.2 2.6 8.2 0.9 3.3 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like WD40 PF00400.27 ESL11103.1 - 1.1e-35 120.1 17.3 1.7e-09 37.2 0.1 5.7 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 ESL11103.1 - 0.00011 20.4 1.6 0.01 14.0 0.2 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.7 ESL11103.1 - 0.0031 17.1 0.0 7.2 6.3 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Ribosomal_60s PF00428.14 ESL11103.1 - 0.0099 16.2 4.0 0.032 14.6 2.8 1.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein PQQ_2 PF13360.1 ESL11103.1 - 0.022 14.2 0.1 11 5.4 0.0 2.8 2 1 0 2 2 2 0 PQQ-like domain DUF3312 PF11768.3 ESL11103.1 - 0.025 12.8 0.0 0.13 10.4 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3312) Clathrin PF00637.15 ESL11104.1 - 1.8e-12 47.0 0.7 7.3e-12 45.0 0.0 2.4 3 0 0 3 3 3 1 Region in Clathrin and VPS F-box PF00646.28 ESL11104.1 - 0.0019 17.8 0.1 0.0096 15.5 0.1 2.2 1 0 0 1 1 1 1 F-box domain PALP PF00291.20 ESL11105.1 - 1.5e-22 80.2 0.0 1.8e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cpn60_TCP1 PF00118.19 ESL11106.1 - 4e-137 457.7 6.3 4.6e-137 457.5 4.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MMR_HSR1 PF01926.18 ESL11107.1 - 1.9e-15 56.7 0.0 6e-15 55.2 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL11107.1 - 2.8e-08 33.7 0.0 1.8e-06 27.8 0.0 2.6 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 ESL11107.1 - 2.4e-06 27.1 0.0 4.9e-05 22.8 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL11107.1 - 2.5e-05 24.7 0.0 0.00021 21.7 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 ESL11107.1 - 0.0011 18.0 0.0 0.0024 17.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Septin PF00735.13 ESL11107.1 - 0.0022 17.0 0.0 0.0064 15.5 0.0 1.8 2 0 0 2 2 2 1 Septin DUF258 PF03193.11 ESL11107.1 - 0.003 16.7 0.0 0.0073 15.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESL11107.1 - 0.033 14.4 0.0 0.15 12.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Gtr1_RagA PF04670.7 ESL11107.1 - 0.055 12.6 0.0 0.27 10.3 0.0 2.1 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Guanylate_kin PF00625.16 ESL11107.1 - 0.057 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Guanylate kinase Herpes_HEPA PF03324.9 ESL11107.1 - 0.085 12.8 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Herpesvirus DNA helicase/primase complex associated protein Histone PF00125.19 ESL11109.1 - 9.5e-19 67.3 0.1 1.4e-18 66.7 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Peptidase_S49 PF01343.13 ESL11111.1 - 0.011 15.5 1.8 0.014 15.1 0.0 1.8 1 1 1 2 2 2 0 Peptidase family S49 Nucleo_P87 PF07267.6 ESL11111.1 - 0.45 9.1 9.1 0.48 9.0 6.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF1168 PF06658.7 ESL11111.1 - 0.48 9.9 25.5 0.81 9.1 17.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1168) Dicty_REP PF05086.7 ESL11111.1 - 0.95 7.1 4.5 1 7.0 3.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Draxin PF15550.1 ESL11111.1 - 2.2 7.8 15.7 2.8 7.5 10.9 1.1 1 0 0 1 1 1 0 Draxin Seryl_tRNA_N PF02403.17 ESL11111.1 - 3.7 7.5 19.3 2.3 8.2 11.6 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GAGA_bind PF06217.7 ESL11111.1 - 4.5 7.1 11.2 5.3 6.9 7.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family RRM_1 PF00076.17 ESL11112.1 - 2.4e-08 33.5 0.0 1.1e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL11112.1 - 0.01 15.7 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Glyco_trans_1_3 PF13528.1 ESL11112.1 - 0.13 11.3 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 1 LRR_8 PF13855.1 ESL11113.1 - 1.1e-18 66.7 20.1 5e-10 38.9 2.6 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ESL11113.1 - 2.3e-15 55.8 11.5 2.4e-06 27.0 0.5 3.4 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL11113.1 - 2.9e-11 41.7 13.2 0.11 12.5 0.1 6.1 5 1 1 6 6 6 4 Leucine Rich Repeat LRR_7 PF13504.1 ESL11113.1 - 1.2e-06 27.7 18.7 0.58 10.5 0.2 5.9 6 0 0 6 6 6 4 Leucine rich repeat LRR_6 PF13516.1 ESL11113.1 - 0.00039 20.1 13.7 2.8 8.2 0.1 5.5 5 1 1 6 6 6 3 Leucine Rich repeat CoA_binding_3 PF13727.1 ESL11115.1 - 0.051 13.4 1.3 0.093 12.5 0.9 1.4 1 0 0 1 1 1 0 CoA-binding domain Coa1 PF08695.5 ESL11115.1 - 0.069 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 DUF1212 PF06738.7 ESL11115.1 - 0.2 11.0 5.7 0.28 10.6 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) CDC37_N PF03234.9 ESL11118.1 - 0.29 11.4 8.0 0.27 11.5 4.5 1.7 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding DnaJ PF00226.26 ESL11119.1 - 4.8e-16 58.2 0.1 1.9e-14 53.1 0.0 2.5 2 0 0 2 2 2 1 DnaJ domain DUF2215 PF10225.4 ESL11119.1 - 2 7.7 0.0 2 7.7 0.0 3.0 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2215) Phytochelatin PF05023.9 ESL11120.1 - 0.072 12.0 0.0 5.2 5.9 0.0 2.3 2 0 0 2 2 2 0 Phytochelatin synthase eIF-6 PF01912.13 ESL11122.1 - 6.5e-81 270.1 0.2 9.7e-81 269.6 0.1 1.2 1 0 0 1 1 1 1 eIF-6 family zf-RanBP PF00641.13 ESL11124.1 - 0.00011 21.1 2.0 0.00019 20.4 1.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Exc PF07825.6 ESL11124.1 - 0.075 12.7 0.0 0.23 11.2 0.0 1.9 1 0 0 1 1 1 0 Excisionase-like protein DUF1697 PF08002.6 ESL11124.1 - 0.091 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) zf-tcix PF14952.1 ESL11124.1 - 0.5 9.7 4.0 1.2 8.4 2.7 1.6 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding Helicase_C_2 PF13307.1 ESL11125.1 - 4.2e-46 156.9 0.0 9.5e-46 155.8 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESL11125.1 - 3.7e-24 85.0 0.5 6e-17 61.5 0.0 3.5 2 1 0 2 2 2 2 DEAD_2 DEAD PF00270.24 ESL11125.1 - 3.7e-05 23.2 0.0 0.00062 19.2 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.1 ESL11125.1 - 0.00015 21.4 2.2 0.00021 20.9 0.4 2.2 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 ESL11125.1 - 0.00049 19.9 0.0 0.44 10.3 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_11 PF13086.1 ESL11125.1 - 0.046 13.3 0.0 0.2 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain SNF2_N PF00176.18 ESL11125.1 - 0.078 11.7 0.0 0.23 10.2 0.0 1.8 2 0 0 2 2 2 0 SNF2 family N-terminal domain RNF111_N PF15303.1 ESL11125.1 - 0.1 12.1 9.7 0.19 11.2 4.3 2.3 1 1 1 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus Kinesin PF00225.18 ESL11126.1 - 1.3e-79 267.2 0.1 2e-79 266.7 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain IncA PF04156.9 ESL11126.1 - 0.00024 20.7 0.3 0.0069 15.9 0.0 2.3 2 0 0 2 2 2 1 IncA protein AAA_30 PF13604.1 ESL11126.1 - 0.13 11.8 3.0 0.42 10.1 0.8 2.6 2 1 0 2 2 2 0 AAA domain KLRAQ PF10205.4 ESL11126.1 - 0.41 10.7 4.6 0.2 11.7 0.3 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Surfac_D-trimer PF09006.6 ESL11126.1 - 0.81 9.4 3.2 1 9.1 0.2 2.5 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation TTL PF03133.10 ESL11128.1 - 3.4e-54 183.7 0.0 5.1e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESL11128.1 - 0.00052 19.7 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain DUF374 PF04028.8 ESL11128.1 - 0.0084 15.3 0.0 0.027 13.6 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF374) ATPgrasp_Ter PF15632.1 ESL11128.1 - 0.12 11.0 0.0 0.25 10.0 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon ATPgrasp_YheCD PF14398.1 ESL11128.1 - 0.2 10.4 0.0 0.53 9.0 0.0 1.7 1 1 0 1 1 1 0 YheC/D like ATP-grasp DUF2569 PF10754.4 ESL11129.1 - 0.026 14.7 5.3 0.033 14.4 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Solute_trans_a PF03619.11 ESL11130.1 - 1.5e-87 293.3 18.3 2e-87 293.0 12.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha RICTOR_M PF14666.1 ESL11132.1 - 3.2e-53 180.0 0.0 9.6e-53 178.4 0.0 1.8 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_N PF14664.1 ESL11132.1 - 1.1e-13 50.5 2.7 8e-11 41.1 0.2 2.7 3 0 0 3 3 3 2 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.1 ESL11132.1 - 5.6e-10 39.1 1.3 4.4e-09 36.3 0.2 3.0 3 1 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 ESL11132.1 - 3.2e-05 23.7 1.9 0.00057 19.7 0.4 3.4 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.17 ESL11132.1 - 0.17 12.0 1.5 3.5 7.9 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat ATP-synt_C PF00137.16 ESL11133.1 - 9.6e-27 92.6 32.3 4.8e-17 61.6 7.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2592 PF10766.4 ESL11133.1 - 0.027 13.8 4.3 0.027 13.8 3.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2592) GerA PF03323.8 ESL11133.1 - 2.2 6.2 7.0 2.3 6.2 0.8 2.1 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Abi PF02517.11 ESL11133.1 - 7.5 6.7 7.0 39 4.4 4.2 2.4 1 1 0 1 1 1 0 CAAX protease self-immunity DUF4064 PF13273.1 ESL11133.1 - 9.3 6.4 16.1 1.4 9.0 4.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) MIP PF00230.15 ESL11134.1 - 2.2e-34 118.9 16.2 2.7e-34 118.6 11.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF4203 PF13886.1 ESL11134.1 - 0.0023 17.4 5.3 0.0023 17.4 3.7 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4203) HSP70 PF00012.15 ESL11135.1 - 2.8e-80 269.9 0.4 3.5e-80 269.6 0.3 1.0 1 0 0 1 1 1 1 Hsp70 protein FtsA PF14450.1 ESL11135.1 - 0.0057 16.4 0.1 0.056 13.2 0.1 2.3 1 1 1 2 2 2 1 Cell division protein FtsA MreB_Mbl PF06723.8 ESL11135.1 - 0.036 12.6 0.1 4.5 5.7 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein Coatomer_WDAD PF04053.9 ESL11137.1 - 2.4e-94 316.6 0.3 3.3e-94 316.1 0.2 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 ESL11137.1 - 1.4e-77 261.0 0.0 2.2e-77 260.4 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus TPR_11 PF13414.1 ESL11139.1 - 1.2e-18 66.5 4.2 9e-13 47.6 0.2 2.4 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESL11139.1 - 2e-14 52.4 8.2 4.9e-06 25.9 1.6 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11139.1 - 6.3e-14 50.7 7.7 2.1e-05 24.0 1.7 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESL11139.1 - 3.1e-05 23.8 2.5 0.0022 17.9 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESL11139.1 - 0.0003 20.3 5.6 0.0014 18.3 0.8 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL11139.1 - 0.00048 19.9 1.6 0.043 13.6 0.7 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL11139.1 - 0.0029 17.6 1.0 1.6 9.1 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11139.1 - 0.003 17.8 1.9 0.011 16.0 1.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESL11139.1 - 0.0031 18.1 3.2 0.0031 18.1 2.2 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.13 ESL11139.1 - 0.0035 17.2 3.7 1.3 8.9 0.3 2.8 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ESL11139.1 - 0.0036 16.9 2.3 0.63 9.9 0.4 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11139.1 - 0.1 13.2 1.1 0.1 13.2 0.8 4.0 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL11139.1 - 0.19 12.2 7.7 0.12 12.8 1.4 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat ThiF PF00899.16 ESL11140.1 - 0.0023 17.7 0.2 0.0062 16.3 0.1 1.8 2 0 0 2 2 2 1 ThiF family TetR_C_6 PF13977.1 ESL11140.1 - 0.007 16.3 0.0 0.026 14.5 0.0 2.0 1 0 0 1 1 1 1 Bacterial transcriptional repressor U-box PF04564.10 ESL11141.1 - 0.00013 21.8 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 U-box domain Sec34 PF04136.10 ESL11141.1 - 0.0014 18.3 1.0 0.0041 16.8 0.0 2.0 2 0 0 2 2 2 1 Sec34-like family UCR_hinge PF02320.11 ESL11141.1 - 0.0047 16.8 0.7 0.015 15.2 0.5 1.8 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein DUF4047 PF13256.1 ESL11141.1 - 0.017 15.0 0.2 0.037 13.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) T4SS PF07996.6 ESL11141.1 - 0.048 13.5 2.6 0.21 11.3 1.8 1.9 1 1 0 1 1 1 0 Type IV secretion system proteins PspA_IM30 PF04012.7 ESL11141.1 - 0.11 11.8 0.3 0.18 11.1 0.2 1.3 1 0 0 1 1 1 0 PspA/IM30 family DUF2937 PF11157.3 ESL11141.1 - 0.11 11.8 1.2 2.7 7.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) Trns_repr_metal PF02583.12 ESL11141.1 - 0.16 12.1 1.5 21 5.4 0.1 2.7 3 0 0 3 3 3 0 Metal-sensitive transcriptional repressor Secretin_N_2 PF07655.8 ESL11141.1 - 0.18 12.1 2.4 0.36 11.2 1.6 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain zf-CCCH PF00642.19 ESL11141.1 - 5.5 6.7 10.1 2.1 8.1 1.9 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Dynein_heavy PF03028.10 ESL11142.1 - 2.4e-73 247.3 0.0 2e-71 241.0 0.0 2.7 1 1 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor MFS_1 PF07690.11 ESL11143.1 - 8.5e-32 110.2 44.7 7.6e-22 77.4 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM247 PF15444.1 ESL11143.1 - 0.49 10.1 0.0 0.49 10.1 0.0 1.8 2 0 0 2 2 2 0 Transmembrane protein 247 DUF4345 PF14248.1 ESL11144.1 - 0.13 11.7 2.2 0.16 11.4 1.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4345) ABC2_membrane PF01061.19 ESL11145.1 - 2.4e-07 30.1 21.2 2.4e-07 30.1 14.7 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESL11145.1 - 0.00069 19.9 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF563 PF04577.9 ESL11146.1 - 8e-09 35.7 0.0 1.6e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Guanylate_kin PF00625.16 ESL11147.1 - 3.8e-36 124.2 0.0 2.3e-24 85.8 0.0 2.9 2 1 0 2 2 2 2 Guanylate kinase AAA_33 PF13671.1 ESL11147.1 - 6.9e-06 25.9 0.0 0.00018 21.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESL11147.1 - 0.0013 17.9 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESL11147.1 - 0.0022 18.0 0.1 0.004 17.1 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESL11147.1 - 0.0032 17.6 0.0 0.0054 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESL11147.1 - 0.0037 16.9 0.0 0.007 16.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.1 ESL11147.1 - 0.01 15.2 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESL11147.1 - 0.011 16.0 0.1 0.013 15.7 0.1 1.6 1 1 0 1 1 1 0 ABC transporter PBP-Tp47_a PF14889.1 ESL11147.1 - 0.013 14.8 0.3 0.018 14.3 0.2 1.2 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a AAA_29 PF13555.1 ESL11147.1 - 0.016 14.7 0.0 0.034 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 ESL11147.1 - 0.017 15.1 0.0 0.023 14.6 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.9 ESL11147.1 - 0.024 14.3 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 ESL11147.1 - 0.058 13.7 0.0 0.29 11.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL11147.1 - 0.069 13.3 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 ESL11147.1 - 0.07 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_28 PF13521.1 ESL11147.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 ESL11147.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) EF-hand_1 PF00036.27 ESL11149.1 - 3.8e-12 44.5 3.6 1.2e-06 27.3 0.0 3.0 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESL11149.1 - 2.2e-10 39.5 1.1 5.8e-05 22.6 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESL11149.1 - 3.1e-08 33.6 1.3 1.1e-07 31.8 0.1 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL11149.1 - 2.9e-06 26.8 6.1 7e-05 22.3 0.2 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 ESL11149.1 - 5.8e-06 25.4 5.1 9.7e-05 21.5 0.0 3.5 3 1 0 3 3 3 1 EF hand EF-hand_10 PF14788.1 ESL11149.1 - 0.02 14.5 0.0 0.94 9.1 0.0 2.1 2 0 0 2 2 2 0 EF hand Hexapep PF00132.19 ESL11151.1 - 2.6e-13 48.8 0.5 3.9e-05 22.9 0.0 3.3 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) D5_N PF08706.6 ESL11151.1 - 0.064 13.3 0.2 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 D5 N terminal like Inositol_P PF00459.20 ESL11152.1 - 2.3e-52 177.9 0.1 5.2e-52 176.8 0.1 1.6 1 1 0 1 1 1 1 Inositol monophosphatase family FPN1 PF06963.7 ESL11153.1 - 0.027 12.8 0.0 0.029 12.7 0.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) IncA PF04156.9 ESL11154.1 - 0.0095 15.5 14.3 0.49 9.9 3.7 2.3 1 1 1 2 2 2 2 IncA protein IRF-2BP1_2 PF11261.3 ESL11154.1 - 0.016 14.6 0.9 0.77 9.2 0.0 2.8 2 1 1 3 3 3 0 Interferon regulatory factor 2-binding protein zinc finger RSS_P20 PF11757.3 ESL11154.1 - 0.042 13.9 0.5 0.11 12.5 0.2 1.7 1 1 0 1 1 1 0 Suppressor of RNA silencing P21-like DUF2096 PF09869.4 ESL11154.1 - 0.045 13.6 0.8 0.061 13.1 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) GAS PF13851.1 ESL11154.1 - 0.053 12.6 9.4 0.056 12.6 1.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.3 ESL11154.1 - 0.39 10.6 11.9 0.82 9.5 3.2 2.2 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spectrin PF00435.16 ESL11154.1 - 1.1 9.6 6.5 0.82 9.9 1.3 2.5 1 1 1 2 2 2 0 Spectrin repeat DUF972 PF06156.8 ESL11154.1 - 1.1 9.5 8.3 61 4.0 5.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.7 ESL11154.1 - 2.4 7.8 12.8 83 2.9 8.8 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 ESL11154.1 - 6.2 5.6 8.3 8.2 5.2 3.8 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 LIM PF00412.17 ESL11155.1 - 0.00026 20.9 1.0 0.00026 20.9 0.7 1.7 2 0 0 2 2 2 1 LIM domain UPF0167 PF03691.9 ESL11155.1 - 0.032 13.6 2.0 2.1 7.7 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0167) Lar_restr_allev PF14354.1 ESL11155.1 - 0.069 13.4 1.3 3.1 8.1 0.0 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.2 ESL11155.1 - 0.34 10.7 4.8 3.7 7.4 3.4 2.3 1 1 0 1 1 1 0 Double zinc ribbon NAD_binding_5 PF07994.7 ESL11156.1 - 7e-105 350.7 0.0 8.4e-105 350.4 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 ESL11156.1 - 2.5e-45 152.8 0.0 4.9e-45 151.9 0.0 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Hexapep PF00132.19 ESL11157.1 - 5.3e-14 51.0 11.4 6.9e-05 22.1 0.1 3.6 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESL11157.1 - 0.004 16.6 7.8 0.045 13.3 1.6 2.7 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase MatE PF01554.13 ESL11158.1 - 3.7e-34 117.6 32.0 1.1e-21 77.1 7.3 2.7 3 0 0 3 3 3 2 MatE FAM176 PF14851.1 ESL11158.1 - 0.028 14.0 3.1 0.064 12.9 0.1 2.2 2 0 0 2 2 2 0 FAM176 family End_N_terminal PF12218.3 ESL11158.1 - 0.14 11.6 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase Ribosomal_L5_C PF00673.16 ESL11159.1 - 1e-21 76.4 0.0 1.7e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 ESL11159.1 - 3.8e-16 58.6 0.2 2.3e-15 56.1 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L5 Glu_syn_central PF04898.9 ESL11159.1 - 0.044 13.0 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 Glutamate synthase central domain Sel1 PF08238.7 ESL11159.1 - 0.073 13.7 0.7 0.17 12.5 0.1 1.9 2 0 0 2 2 2 0 Sel1 repeat DRMBL PF07522.9 ESL11161.1 - 3.9e-18 65.4 0.1 6.6e-17 61.5 0.0 2.5 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 ESL11161.1 - 9.1e-08 31.8 0.0 2.1e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESL11161.1 - 0.031 13.9 0.6 0.1 12.2 0.4 1.8 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily FPL PF09758.4 ESL11162.1 - 2e-55 186.6 2.0 3.3e-55 185.9 1.4 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF2342 PF10103.4 ESL11162.1 - 0.0083 15.1 0.2 0.015 14.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2342) UQ_con PF00179.21 ESL11163.1 - 4.9e-53 178.3 0.0 5.5e-53 178.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESL11163.1 - 0.0021 17.9 0.0 0.0023 17.8 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 ESL11163.1 - 0.0042 16.8 0.0 0.005 16.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 ESL11163.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 UEV domain DSPc PF00782.15 ESL11166.1 - 1.4e-22 79.7 0.0 2.8e-22 78.7 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Pyridoxal_deC PF00282.14 ESL11167.1 - 1.5e-19 69.6 0.0 4.7e-19 68.0 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 ESL11167.1 - 1.4e-09 37.2 0.0 1.1e-08 34.1 0.0 2.4 2 1 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ESL11167.1 - 0.001 18.1 0.1 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family TroA PF01297.12 ESL11167.1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Periplasmic solute binding protein family Cation_efflux PF01545.16 ESL11168.1 - 7.6e-57 192.5 5.3 9e-57 192.3 3.7 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ESL11168.1 - 0.00042 19.4 4.4 0.00087 18.3 3.0 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Gar1 PF04410.9 ESL11169.1 - 1.3e-25 89.6 0.0 2e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DUF1656 PF07869.7 ESL11171.1 - 2.7 7.8 7.4 0.54 10.0 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) Mcp5_PH PF12814.2 ESL11172.1 - 2.1e-12 47.0 0.2 3.4e-12 46.3 0.1 1.2 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF4200 PF13863.1 ESL11173.1 - 0.011 15.6 4.4 0.011 15.6 3.1 8.7 4 3 4 9 9 9 0 Domain of unknown function (DUF4200) Sulfatase PF00884.18 ESL11174.1 - 6.2e-05 22.3 0.0 0.00048 19.4 0.0 2.0 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.17 ESL11174.1 - 0.04 13.2 0.0 0.4 9.9 0.0 2.4 2 1 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase CLASP_N PF12348.3 ESL11175.1 - 3.3e-09 36.4 5.1 8.8e-05 21.9 0.3 4.4 5 0 0 5 5 5 2 CLASP N terminal HEAT_2 PF13646.1 ESL11175.1 - 6.1e-08 32.8 9.2 0.16 12.2 0.0 7.2 6 2 2 8 8 8 3 HEAT repeats NUC173 PF08161.7 ESL11175.1 - 4.5e-07 29.4 0.2 0.0047 16.3 0.0 3.4 2 1 1 3 3 3 2 NUC173 domain HEAT PF02985.17 ESL11175.1 - 0.00041 20.2 13.2 1.9 8.7 0.1 7.9 10 0 0 10 10 10 2 HEAT repeat HEAT_EZ PF13513.1 ESL11175.1 - 0.0018 18.7 1.6 4.4 7.9 0.2 4.7 4 0 0 4 4 4 1 HEAT-like repeat H2TH PF06831.9 ESL11175.1 - 0.09 12.5 0.0 0.34 10.6 0.0 2.0 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain Pkinase PF00069.20 ESL11176.1 - 9e-51 172.5 0.0 4.3e-50 170.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11176.1 - 9.3e-34 116.6 0.0 4.1e-31 107.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PH_3 PF14593.1 ESL11176.1 - 4.3e-19 68.3 0.0 7.7e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 PH domain APH PF01636.18 ESL11176.1 - 0.00011 22.0 0.5 0.0023 17.7 0.3 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESL11176.1 - 0.00022 20.2 0.0 0.00031 19.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESL11176.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PSP1 PF04468.7 ESL11178.1 - 3.6e-24 84.5 0.1 7e-24 83.6 0.1 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Profilin PF00235.14 ESL11179.1 - 2.5e-36 124.4 0.0 2.9e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Profilin Pro_isomerase PF00160.16 ESL11180.1 - 2.5e-49 167.4 1.0 2.9e-49 167.2 0.7 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RabGAP-TBC PF00566.13 ESL11181.1 - 1.6e-23 83.3 0.1 2.1e-23 82.9 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-C2H2_4 PF13894.1 ESL11182.1 - 4.9e-11 42.1 33.6 0.0021 18.2 1.8 6.2 5 2 2 7 7 7 5 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESL11182.1 - 6.6e-07 29.3 2.2 6.6e-07 29.3 1.5 5.9 7 0 0 7 7 7 1 Zinc-finger double domain zf-BED PF02892.10 ESL11182.1 - 4e-05 23.2 10.3 0.74 9.6 0.0 4.6 3 1 1 4 4 4 3 BED zinc finger CTV_P33 PF07184.6 ESL11182.1 - 0.22 10.3 1.8 0.78 8.5 0.5 2.0 1 1 1 2 2 2 0 Citrus tristeza virus P33 protein zf-TRAF PF02176.13 ESL11182.1 - 0.63 10.4 18.3 0.2 12.0 0.7 3.9 4 1 0 4 4 4 0 TRAF-type zinc finger RNHCP PF12647.2 ESL11182.1 - 1.3 8.9 8.9 2.8 7.8 0.3 3.6 3 1 1 4 4 4 0 RNHCP domain Transpos_assoc PF13963.1 ESL11182.1 - 2.1 8.4 4.9 9.8 6.2 0.2 3.0 4 0 0 4 4 4 0 Transposase-associated domain Cys_rich_CWC PF14375.1 ESL11182.1 - 6.6 6.7 10.8 4 7.4 0.2 3.0 3 0 0 3 3 3 0 Cysteine-rich CWC Mito_carr PF00153.22 ESL11183.1 - 8.4e-58 192.0 2.2 7.3e-19 67.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 ESL11183.1 - 0.028 14.4 1.0 9 6.3 0.0 4.0 4 1 0 4 4 4 0 Tim17/Tim22/Tim23/Pmp24 family DUF830 PF05708.7 ESL11184.1 - 0.00022 21.2 0.0 0.02 14.8 0.0 2.2 2 0 0 2 2 2 2 Orthopoxvirus protein of unknown function (DUF830) FIVAR PF07554.8 ESL11187.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised Sugar-binding Domain 2-oxoacid_dh PF00198.18 ESL11188.1 - 4.9e-81 271.3 0.0 6.6e-81 270.9 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 ESL11188.1 - 1.4e-19 69.4 2.1 2.4e-19 68.7 1.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 ESL11188.1 - 1.4e-05 24.6 0.2 0.063 12.9 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like GCV_H PF01597.14 ESL11188.1 - 0.00049 19.7 0.3 0.00098 18.7 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_2 PF12700.2 ESL11188.1 - 0.0068 15.5 2.2 0.072 12.2 0.1 2.5 2 1 1 3 3 3 1 HlyD family secretion protein HlyD PF00529.15 ESL11188.1 - 0.0079 15.5 3.1 0.0088 15.3 1.0 1.9 2 1 0 2 2 2 1 HlyD family secretion protein HlyD_3 PF13437.1 ESL11188.1 - 0.0099 16.2 0.2 0.091 13.1 0.0 2.2 1 1 1 2 2 2 1 HlyD family secretion protein CRCB PF02537.10 ESL11189.1 - 9.8e-36 122.1 19.6 3.7e-20 71.9 2.7 2.3 2 0 0 2 2 2 2 CrcB-like protein Abi PF02517.11 ESL11189.1 - 0.25 11.4 6.2 0.16 12.1 1.2 2.5 2 0 0 2 2 2 0 CAAX protease self-immunity Pro_isomerase PF00160.16 ESL11191.1 - 1e-32 113.5 0.0 1.1e-32 113.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3659 PF12396.3 ESL11191.1 - 0.018 14.6 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) Met_10 PF02475.11 ESL11192.1 - 1e-41 142.7 0.0 2.4e-36 125.2 0.0 2.1 2 0 0 2 2 2 2 Met-10+ like-protein Methyltransf_18 PF12847.2 ESL11192.1 - 1.7e-05 25.3 0.0 3.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL11192.1 - 6.8e-05 22.8 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL11192.1 - 0.00076 18.8 0.0 0.0017 17.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.1 ESL11192.1 - 0.0074 15.8 0.0 0.016 14.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 ESL11192.1 - 0.014 14.1 0.0 0.021 13.5 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.5 ESL11192.1 - 0.044 13.3 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DNA_methylase PF00145.12 ESL11192.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Cyclin PF08613.6 ESL11195.1 - 8.7e-28 97.6 0.4 1.1e-27 97.2 0.2 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESL11195.1 - 1.5e-11 43.9 0.1 2.6e-11 43.1 0.1 1.4 1 1 0 1 1 1 1 Cyclin, N-terminal domain GAS2 PF02187.12 ESL11195.1 - 0.067 12.9 0.7 0.18 11.5 0.1 1.9 2 0 0 2 2 2 0 Growth-Arrest-Specific Protein 2 Domain UDPGP PF01704.13 ESL11196.1 - 3.6e-29 101.5 0.0 8.8e-29 100.2 0.0 1.6 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 ESL11196.1 - 0.022 14.8 0.0 0.053 13.6 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain AMP-binding PF00501.23 ESL11198.1 - 7.9e-47 159.5 0.0 1e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF1967 PF09269.6 ESL11198.1 - 0.041 13.5 0.1 1 9.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) CBF PF03914.12 ESL11199.1 - 1.1e-37 129.0 0.8 2.8e-37 127.6 0.1 1.8 2 0 0 2 2 2 1 CBF/Mak21 family Sec2p PF06428.6 ESL11199.1 - 0.057 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Ras PF00071.17 ESL11201.1 - 3e-34 117.7 0.0 4.8e-34 117.0 0.0 1.3 1 1 0 1 1 1 1 Ras family Miro PF08477.8 ESL11201.1 - 1.1e-11 45.2 0.0 5.1e-11 43.0 0.0 1.9 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL11201.1 - 2.2e-07 30.2 0.0 1.9e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL11201.1 - 0.00072 19.0 0.0 0.035 13.5 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF4638 PF15472.1 ESL11203.1 - 0.17 11.4 9.6 0.21 11.1 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Methyltransf_14 PF08484.6 ESL11203.1 - 3.1 7.3 5.8 4.3 6.8 4.0 1.3 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain IncFII_repA PF02387.10 ESL11203.1 - 3.5 6.7 10.6 4.7 6.2 7.4 1.1 1 0 0 1 1 1 0 IncFII RepA protein family Atg14 PF10186.4 ESL11203.1 - 7.8 5.3 14.2 8.5 5.2 9.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 KIAA1430 PF13879.1 ESL11204.1 - 5.3e-20 71.6 9.7 8.9e-20 70.9 6.8 1.4 1 0 0 1 1 1 1 KIAA1430 homologue Metalloenzyme PF01676.13 ESL11205.1 - 1.9e-68 230.6 0.0 2.1e-68 230.4 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.8 ESL11205.1 - 2.1e-61 207.1 0.0 2.8e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.17 ESL11205.1 - 0.00044 19.6 0.0 0.00068 19.0 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CotH PF08757.6 ESL11206.1 - 1.8e-06 27.4 0.1 1.3e-05 24.5 0.2 2.0 2 0 0 2 2 2 1 CotH protein Beta_helix PF13229.1 ESL11206.1 - 8.8e-05 22.3 2.8 0.00022 21.0 2.0 1.7 1 0 0 1 1 1 1 Right handed beta helix region PUB PF09409.5 ESL11208.1 - 2.7e-31 107.1 0.0 7.1e-17 60.9 0.0 2.2 2 0 0 2 2 2 2 PUB domain SHOCT PF09851.4 ESL11208.1 - 1.3e-07 30.8 0.5 5.3e-07 28.8 0.4 2.1 1 0 0 1 1 1 1 Short C-terminal domain Exo_endo_phos PF03372.18 ESL11210.1 - 9.2e-18 65.0 0.5 1.5e-17 64.3 0.1 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family XRN_N PF03159.13 ESL11210.1 - 0.23 10.8 0.0 0.56 9.5 0.0 1.5 1 1 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus HMG_box PF00505.14 ESL11212.1 - 0.023 14.9 0.0 0.91 9.8 0.0 2.5 2 0 0 2 2 2 0 HMG (high mobility group) box HMG_box_2 PF09011.5 ESL11212.1 - 0.1 12.9 0.0 10 6.5 0.0 2.5 2 0 0 2 2 2 0 HMG-box domain DCX PF03607.12 ESL11213.1 - 0.0057 16.2 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 Doublecortin SET PF00856.23 ESL11215.1 - 0.003 17.9 0.0 0.0046 17.2 0.0 1.3 1 0 0 1 1 1 1 SET domain Surface_antigen PF11054.3 ESL11215.1 - 0.14 11.5 0.2 0.2 10.9 0.1 1.1 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen Pro_isomerase PF00160.16 ESL11216.1 - 1.4e-46 158.4 0.1 2e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD AA_permease_2 PF13520.1 ESL11217.1 - 6.3e-21 74.3 23.9 7.6e-21 74.1 16.6 1.0 1 0 0 1 1 1 1 Amino acid permease LRR_4 PF12799.2 ESL11218.1 - 3.4e-09 36.1 9.2 0.0039 16.7 0.1 4.4 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL11218.1 - 0.00049 19.8 8.9 0.0089 15.7 0.3 2.9 2 1 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.1 ESL11218.1 - 0.0052 16.7 4.4 14 6.1 0.0 5.4 5 0 0 5 5 5 1 Leucine Rich repeat LRR_7 PF13504.1 ESL11218.1 - 0.033 14.3 11.7 6.8 7.3 0.1 5.9 5 0 0 5 5 5 0 Leucine rich repeat LRR_1 PF00560.28 ESL11218.1 - 0.055 13.5 15.9 3.4 8.0 0.1 5.9 4 2 1 5 5 5 0 Leucine Rich Repeat ADIP PF11559.3 ESL11219.1 - 1.4 8.7 14.7 0.18 11.6 5.7 2.5 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Med21 PF11221.3 ESL11219.1 - 3.7 7.5 10.7 7.2 6.5 0.0 3.2 3 0 0 3 3 3 0 Subunit 21 of Mediator complex UPF0172 PF03665.8 ESL11220.1 - 3e-60 203.0 0.0 3.4e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Amino_oxidase PF01593.19 ESL11222.1 - 1.8e-15 56.9 0.0 2.3e-08 33.5 0.0 2.3 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 ESL11222.1 - 1.6e-09 37.6 0.3 4.5e-09 36.2 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESL11222.1 - 0.017 14.0 0.0 0.035 13.0 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESL11222.1 - 0.043 13.8 0.1 0.083 12.9 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase XPG_I PF00867.13 ESL11223.1 - 1.4e-24 85.9 0.1 2.8e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 ESL11223.1 - 3.4e-17 62.5 0.0 4.1e-16 59.0 0.0 2.3 1 1 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 ESL11223.1 - 4.2e-05 23.1 0.5 9.5e-05 22.0 0.3 1.5 1 0 0 1 1 1 1 XPG domain containing EF-hand_1 PF00036.27 ESL11224.1 - 2e-26 89.2 11.7 2.2e-09 35.9 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 ESL11224.1 - 1.1e-22 77.8 5.5 2.7e-09 36.1 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 ESL11224.1 - 6.3e-22 77.4 7.3 1.6e-12 47.3 1.7 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL11224.1 - 6.6e-20 70.4 12.7 2.7e-13 49.2 0.8 4.5 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 ESL11224.1 - 5.2e-17 60.3 13.4 9.2e-07 27.9 0.2 3.7 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 ESL11224.1 - 3.8e-12 45.9 0.1 2.1e-08 33.9 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 ESL11224.1 - 2.6e-05 23.8 0.8 0.14 11.9 0.0 2.5 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 ESL11224.1 - 0.0088 16.3 0.1 5.9 7.2 0.0 2.2 2 0 0 2 2 2 2 Toprim-like FtsK_SpoIIIE PF01580.13 ESL11224.1 - 0.047 13.1 3.0 0.2 11.0 0.9 2.3 1 1 1 2 2 2 0 FtsK/SpoIIIE family DUF853 PF05872.7 ESL11224.1 - 0.069 11.4 0.5 3 6.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Ribosomal_L11 PF00298.14 ESL11224.1 - 0.14 12.2 0.2 3.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain MgtE_N PF03448.12 ESL11224.1 - 0.26 11.6 3.2 0.57 10.5 0.5 2.2 2 0 0 2 2 2 0 MgtE intracellular N domain DUF3008 PF11450.3 ESL11224.1 - 0.32 11.1 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 1 0 Protein of unknwon function (DUF3008) EF-hand_10 PF14788.1 ESL11224.1 - 0.5 10.0 2.4 5.2 6.8 0.3 2.7 3 0 0 3 3 3 0 EF hand ABC_tran PF00005.22 ESL11225.1 - 7.2e-45 152.6 0.5 9.6e-21 74.5 0.0 3.5 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 ESL11225.1 - 5.9e-17 62.5 0.1 0.0015 18.5 0.0 4.3 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 ESL11225.1 - 6.7e-12 45.1 0.0 0.00011 21.5 0.0 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 ESL11225.1 - 4.5e-07 29.1 0.1 0.0024 17.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESL11225.1 - 8e-07 29.9 1.7 0.0086 16.8 0.0 4.0 3 1 1 4 4 3 2 AAA domain AAA_29 PF13555.1 ESL11225.1 - 3.2e-06 26.5 0.6 0.08 12.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.1 ESL11225.1 - 8e-05 22.4 1.0 0.027 14.3 0.0 3.9 3 2 0 3 3 2 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 ESL11225.1 - 0.00018 21.5 0.7 0.24 11.3 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_14 PF13173.1 ESL11225.1 - 0.00052 19.9 0.0 1.5 8.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 ESL11225.1 - 0.0013 18.9 0.0 0.48 10.6 0.0 2.6 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.18 ESL11225.1 - 0.0013 18.7 0.1 0.27 11.1 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.24 ESL11225.1 - 0.0015 18.7 3.6 1.6 8.9 0.0 3.7 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ABC_tran_2 PF12848.2 ESL11225.1 - 0.0023 17.7 0.9 0.0023 17.7 0.6 4.0 3 1 1 4 4 3 1 ABC transporter AAA_33 PF13671.1 ESL11225.1 - 0.0065 16.3 0.0 0.86 9.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 ESL11225.1 - 0.0084 16.2 0.4 2 8.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain Miro PF08477.8 ESL11225.1 - 0.01 16.3 0.6 1.7 9.1 0.0 3.0 3 0 0 3 3 2 0 Miro-like protein AAA_10 PF12846.2 ESL11225.1 - 0.012 15.0 1.0 0.53 9.6 0.1 3.0 3 1 0 3 3 3 0 AAA-like domain ArgK PF03308.11 ESL11225.1 - 0.015 14.0 0.1 1.4 7.6 0.0 2.6 2 0 0 2 2 2 0 ArgK protein Rad17 PF03215.10 ESL11225.1 - 0.026 13.2 0.2 1.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein NACHT PF05729.7 ESL11225.1 - 0.031 13.9 0.1 3.9 7.1 0.0 2.9 3 0 0 3 3 3 0 NACHT domain T2SE PF00437.15 ESL11225.1 - 0.04 12.8 0.0 5.1 5.9 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_28 PF13521.1 ESL11225.1 - 0.046 13.6 6.2 2.4 8.0 0.0 3.7 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 ESL11225.1 - 0.057 13.7 6.6 2.2 8.5 0.0 3.7 4 0 0 4 4 4 0 AAA domain Dynamin_N PF00350.18 ESL11225.1 - 0.072 12.9 4.5 2.3 8.0 0.0 3.4 4 0 0 4 4 4 0 Dynamin family YchF-GTPase_C PF06071.8 ESL11226.1 - 1.8e-38 130.1 1.2 3.9e-38 129.0 0.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) TGS PF02824.16 ESL11226.1 - 0.0019 18.0 0.1 0.0052 16.5 0.0 1.8 2 0 0 2 2 2 1 TGS domain MCM PF00493.18 ESL11227.1 - 2.6e-120 401.2 0.1 2.6e-120 401.2 0.1 1.4 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 ESL11227.1 - 3.1e-14 53.5 0.0 1.1e-13 51.7 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESL11227.1 - 6e-07 28.8 0.0 6e-06 25.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESL11227.1 - 0.00037 20.0 0.0 0.0015 18.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL11227.1 - 0.00088 19.0 0.1 0.0032 17.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) PUA PF01472.15 ESL11227.1 - 0.011 15.3 1.4 4.6 7.0 0.1 2.5 2 0 0 2 2 2 0 PUA domain tRNA_anti_2 PF13742.1 ESL11227.1 - 0.041 13.7 0.1 2.8 7.8 0.0 3.1 3 0 0 3 3 3 0 OB-fold nucleic acid binding domain Sigma54_activat PF00158.21 ESL11227.1 - 0.042 13.3 0.0 0.12 11.7 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Longin PF13774.1 ESL11228.1 - 2.6e-19 68.5 0.0 6.6e-19 67.2 0.0 1.7 1 1 1 2 2 2 1 Regulated-SNARE-like domain DUF498 PF04430.9 ESL11228.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) CoxIIa PF08113.6 ESL11228.1 - 0.34 10.6 3.8 0.7 9.6 2.6 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family Med25_VWA PF11265.3 ESL11230.1 - 0.053 12.5 0.0 0.096 11.6 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A DUF1515 PF07439.6 ESL11230.1 - 0.95 9.2 6.0 4.1 7.2 0.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DivIVA PF05103.8 ESL11230.1 - 2 8.5 21.5 0.024 14.6 3.4 3.7 2 1 0 3 3 3 0 DivIVA protein PP2C PF00481.16 ESL11231.1 - 1.1e-05 25.0 0.0 3.4e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Protein phosphatase 2C Actin PF00022.14 ESL11232.1 - 8.3e-148 492.0 0.0 9.7e-148 491.7 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ESL11232.1 - 0.012 16.0 0.1 0.13 12.6 0.0 2.2 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Filament PF00038.16 ESL11233.1 - 0.0012 18.4 45.1 0.0012 18.4 31.3 5.4 1 1 3 4 4 4 2 Intermediate filament protein Baculo_PEP_C PF04513.7 ESL11233.1 - 6.8 6.5 58.4 2.7 7.8 0.0 9.4 5 3 4 10 10 10 0 Baculovirus polyhedron envelope protein, PEP, C terminus ZZ PF00569.12 ESL11234.1 - 0.0012 18.3 1.3 0.0034 16.9 0.9 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type FYVE PF01363.16 ESL11234.1 - 0.036 13.9 0.8 0.073 12.9 0.5 1.5 1 0 0 1 1 1 0 FYVE zinc finger Clathrin PF00637.15 ESL11235.1 - 7.6e-07 28.8 0.6 2.3e-06 27.2 0.1 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 ESL11235.1 - 0.011 15.5 2.1 0.038 13.8 1.5 2.0 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 ESL11235.1 - 0.011 15.4 1.8 0.011 15.4 1.3 2.4 3 0 0 3 3 3 0 zinc-RING finger domain DUF3673 PF12425.3 ESL11235.1 - 0.024 14.4 0.3 0.079 12.8 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) zf-C3HC4_2 PF13923.1 ESL11235.1 - 0.029 14.4 1.7 0.14 12.2 1.2 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESL11235.1 - 0.14 12.3 0.3 0.35 11.0 0.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger Nodulin-like PF06813.8 ESL11236.1 - 6.6e-09 35.3 14.7 2e-08 33.8 7.8 2.5 2 1 0 2 2 2 1 Nodulin-like MFS_1 PF07690.11 ESL11236.1 - 8e-06 24.7 12.7 0.00029 19.6 6.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF21 PF01595.15 ESL11236.1 - 0.0074 15.6 0.4 0.016 14.4 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF21 DnaJ PF00226.26 ESL11239.1 - 8.5e-22 76.6 0.2 2.9e-21 74.9 0.1 2.0 2 0 0 2 2 2 1 DnaJ domain DNA_pol3_a_NII PF11490.3 ESL11239.1 - 2.2 7.9 7.0 11 5.7 0.0 2.5 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II IncA PF04156.9 ESL11239.1 - 2.5 7.6 5.0 3.5 7.1 3.4 1.2 1 0 0 1 1 1 0 IncA protein Rsc14 PF08586.5 ESL11239.1 - 6.6 7.2 6.7 2.4 8.7 2.0 2.0 1 1 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Peptidase_M1 PF01433.15 ESL11240.1 - 1.9e-86 290.6 0.8 2.8e-86 290.0 0.6 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 ESL11240.1 - 2.8e-41 141.8 2.9 3.3e-41 141.5 1.5 1.5 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 ESL11240.1 - 1.9e-20 73.1 0.7 4.1e-20 72.1 0.5 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily GSHPx PF00255.14 ESL11241.1 - 1.3e-27 95.3 0.0 1.6e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 ESL11241.1 - 0.0069 16.0 0.0 0.0096 15.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Pkinase PF00069.20 ESL11242.1 - 2.2e-48 164.6 0.0 3.2e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11242.1 - 1.4e-15 57.0 0.0 2e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL11242.1 - 0.0015 18.2 0.5 0.35 10.5 0.0 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family BioT2 PF15368.1 ESL11242.1 - 0.026 14.3 0.1 0.042 13.6 0.1 1.3 1 0 0 1 1 1 0 Spermatogenesis family BioT2 WD40 PF00400.27 ESL11244.1 - 2.9e-09 36.4 6.9 0.034 14.0 0.0 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat SBP_bac_1 PF01547.20 ESL11244.1 - 0.3 10.7 0.0 0.47 10.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Ribosomal_S4e PF00900.15 ESL11245.1 - 1e-24 86.0 0.4 1.9e-24 85.1 0.3 1.5 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.7 ESL11245.1 - 1.9e-18 66.0 2.6 6.3e-18 64.3 1.8 2.0 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 ESL11245.1 - 7.2e-11 41.3 0.5 1.5e-10 40.2 0.0 1.9 2 0 0 2 2 2 1 S4 domain KOW PF00467.24 ESL11245.1 - 5.2e-06 25.9 0.5 2e-05 24.0 0.1 2.2 2 0 0 2 2 2 1 KOW motif Dak1 PF02733.12 ESL11248.1 - 2.2e-83 279.5 0.4 3.2e-83 279.0 0.2 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 ESL11248.1 - 1.6e-37 128.8 4.2 3.5e-37 127.7 2.9 1.6 1 0 0 1 1 1 1 DAK2 domain KfrA_N PF11740.3 ESL11248.1 - 1.1 9.6 6.2 1.5 9.3 3.1 2.1 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Ribosomal_S14 PF00253.16 ESL11249.1 - 6.5e-17 60.6 3.0 6.9e-17 60.5 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e PHF5 PF03660.9 ESL11249.1 - 0.014 15.4 0.2 0.014 15.4 0.2 1.1 1 0 0 1 1 1 0 PHF5-like protein Ribosomal_L40e PF01020.12 ESL11249.1 - 0.33 10.5 3.3 1.6 8.4 0.7 2.3 2 1 0 2 2 2 0 Ribosomal L40e family Pkinase PF00069.20 ESL11251.1 - 5.3e-47 160.1 0.0 6.4e-36 123.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11251.1 - 3.1e-28 98.5 0.0 7.1e-28 97.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11251.1 - 3.6e-09 35.9 0.1 1.5e-08 33.9 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 ESL11251.1 - 0.35 9.6 0.0 0.62 8.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Lysine_decarbox PF03641.9 ESL11252.1 - 0.074 12.8 0.0 0.86 9.4 0.0 2.3 2 0 0 2 2 2 0 Possible lysine decarboxylase DUF4139 PF13598.1 ESL11253.1 - 2.5e-69 234.0 0.7 5e-69 233.0 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.1 ESL11253.1 - 0.00044 20.6 19.6 0.00069 20.0 0.5 4.0 4 0 0 4 4 4 2 N-terminal domain of unknown function (DUF4140) CENP-F_N PF10481.4 ESL11253.1 - 0.012 14.9 1.4 0.023 14.0 0.9 1.4 1 0 0 1 1 1 0 Cenp-F N-terminal domain HALZ PF02183.13 ESL11253.1 - 0.015 14.9 0.5 0.045 13.4 0.4 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper TMF_DNA_bd PF12329.3 ESL11253.1 - 0.034 13.9 4.2 1.9 8.3 0.1 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Striatin PF08232.7 ESL11253.1 - 0.038 14.3 1.3 0.3 11.4 0.0 2.4 2 0 0 2 2 2 0 Striatin family BRE1 PF08647.6 ESL11253.1 - 0.075 13.0 3.6 0.14 12.1 0.0 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Val_tRNA-synt_C PF10458.4 ESL11253.1 - 0.089 12.8 0.4 0.089 12.8 0.3 2.5 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm PspA_IM30 PF04012.7 ESL11253.1 - 0.12 11.6 8.5 1.4 8.2 1.1 2.3 2 0 0 2 2 2 0 PspA/IM30 family DivIC PF04977.10 ESL11253.1 - 0.22 11.0 9.3 0.15 11.5 0.7 2.4 2 0 0 2 2 2 0 Septum formation initiator TBPIP PF07106.8 ESL11253.1 - 0.25 10.8 2.9 2 7.9 0.1 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Prefoldin_2 PF01920.15 ESL11253.1 - 0.58 9.9 8.5 3.2 7.5 0.2 2.5 2 0 0 2 2 2 0 Prefoldin subunit Flg_hook PF02120.11 ESL11253.1 - 1.1 9.0 5.7 15 5.3 0.7 3.2 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK IncA PF04156.9 ESL11253.1 - 5.6 6.5 10.5 59 3.1 7.3 2.2 1 1 0 1 1 1 0 IncA protein Aha1_N PF09229.6 ESL11254.1 - 4.1e-33 114.1 0.8 6.3e-33 113.4 0.5 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 ESL11254.1 - 1.9e-14 53.8 0.0 4.5e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Helicase_C PF00271.26 ESL11255.1 - 6.1e-20 70.8 0.0 1.3e-19 69.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESL11255.1 - 1.1e-16 60.0 0.1 2.1e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) DEAD PF00270.24 ESL11255.1 - 9.7e-13 47.9 0.1 1.9e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD PF00270.24 ESL11256.1 - 5.2e-26 91.1 0.0 8.6e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL11256.1 - 3.4e-06 26.8 0.0 9.3e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL11256.1 - 2.3e-05 24.3 0.0 4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 ESL11256.1 - 0.00054 18.9 0.0 0.0011 17.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.1 ESL11256.1 - 0.0057 16.6 0.2 0.035 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 ESL11256.1 - 0.0099 15.6 2.5 0.013 15.1 0.7 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 ESL11256.1 - 0.011 15.8 0.0 0.12 12.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESL11256.1 - 0.061 12.7 0.1 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 ESL11256.1 - 0.077 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ubiquitin PF00240.18 ESL11258.1 - 2.9e-06 26.5 0.0 5.5e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family zf-B_box PF00643.19 ESL11258.1 - 0.0025 17.6 3.6 0.0025 17.6 2.5 6.3 5 2 0 5 5 5 1 B-box zinc finger Rad60-SLD PF11976.3 ESL11258.1 - 0.036 13.7 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like FAA_hydrolase PF01557.13 ESL11259.1 - 1.5e-44 152.0 0.0 2e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Inositol_P PF00459.20 ESL11260.1 - 1.2e-23 83.8 0.0 2.4e-23 82.7 0.0 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family CIDE-N PF02017.10 ESL11260.1 - 0.13 12.0 0.0 16 5.3 0.0 2.6 2 0 0 2 2 2 0 CIDE-N domain Thioredoxin PF00085.15 ESL11261.1 - 1.5e-27 95.2 0.0 2.3e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL11261.1 - 2.8e-10 40.3 0.0 1.1e-09 38.4 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESL11261.1 - 2.9e-05 24.1 0.0 0.00024 21.1 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.1 ESL11261.1 - 5.6e-05 23.0 0.0 9.5e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 ESL11261.1 - 0.0016 17.9 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 ESL11261.1 - 0.027 14.1 0.0 0.046 13.3 0.0 1.4 1 1 0 1 1 1 0 AhpC/TSA family HyaE PF07449.6 ESL11261.1 - 0.03 14.2 0.0 0.07 13.0 0.0 1.5 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Mu-like_Com PF10122.4 ESL11261.1 - 0.054 12.5 0.1 0.097 11.7 0.1 1.3 1 0 0 1 1 1 0 Mu-like prophage protein Com Thioredoxin_6 PF13848.1 ESL11261.1 - 0.073 12.8 0.0 0.36 10.6 0.0 1.8 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.1 ESL11261.1 - 0.081 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain PPR PF01535.15 ESL11262.1 - 0.00064 19.5 1.0 28 5.0 0.1 5.5 6 0 0 6 6 6 1 PPR repeat PPR_3 PF13812.1 ESL11262.1 - 1 9.7 6.9 25 5.4 0.0 5.4 6 0 0 6 6 6 0 Pentatricopeptide repeat domain PUF PF00806.14 ESL11263.1 - 2.8e-37 124.0 3.6 5.2e-05 22.4 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Ank_2 PF12796.2 ESL11263.1 - 0.06 13.6 0.2 0.06 13.6 0.2 2.0 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) APC_crr PF05923.7 ESL11263.1 - 0.17 11.5 1.7 2.2 8.0 0.0 2.7 2 0 0 2 2 2 0 APC cysteine-rich region Rubis-subs-bind PF09273.6 ESL11265.1 - 3.5e-06 26.9 0.0 1.8e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.23 ESL11265.1 - 0.055 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 SET domain Dynein_light PF01221.13 ESL11266.1 - 1.2e-32 111.7 0.9 1.3e-32 111.6 0.6 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Vasohibin PF14822.1 ESL11266.1 - 0.0012 18.0 0.1 0.0012 18.0 0.1 1.2 1 0 0 1 1 1 1 Vasohibin PPK2 PF03976.9 ESL11267.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) 7tm_7 PF08395.7 ESL11268.1 - 0.029 13.4 2.0 0.039 12.9 1.4 1.3 1 1 0 1 1 1 0 7tm Chemosensory receptor SNF2_N PF00176.18 ESL11269.1 - 7.4e-29 100.4 0.0 1.2e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Tet_JBP PF12851.2 ESL11269.1 - 1.3e-22 79.9 0.2 4e-22 78.3 0.1 1.8 2 0 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily Helicase_C PF00271.26 ESL11269.1 - 1.4e-13 50.5 0.0 3.8e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL11269.1 - 1e-05 25.1 0.0 2.1e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESL11269.1 - 7.3e-05 22.6 0.0 0.00016 21.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit LytTR PF04397.10 ESL11269.1 - 0.055 13.5 0.0 2.1 8.4 0.0 2.9 3 0 0 3 3 3 0 LytTr DNA-binding domain TMEM107 PF14995.1 ESL11270.1 - 8e-30 103.5 2.9 8e-30 103.5 2.0 2.3 2 1 0 2 2 2 1 Transmembrane protein Na_H_Exchanger PF00999.16 ESL11271.1 - 5.4e-47 160.1 43.4 8.6e-47 159.4 30.1 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF3449 PF11931.3 ESL11272.1 - 1.1e-43 149.0 0.4 1.7e-43 148.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) Hph PF13694.1 ESL11272.1 - 0.14 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family NARG2_C PF10505.4 ESL11273.1 - 0.0034 16.6 0.0 0.0066 15.6 0.0 1.4 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus PRA1 PF03208.14 ESL11274.1 - 8.9e-08 31.6 5.8 1.7e-07 30.7 4.0 1.4 1 0 0 1 1 1 1 PRA1 family protein Nol1_Nop2_Fmu PF01189.12 ESL11275.1 - 9.5e-83 277.8 0.1 3.7e-82 275.9 0.0 1.8 2 0 0 2 2 2 1 NOL1/NOP2/sun family FtsJ PF01728.14 ESL11275.1 - 0.00055 19.9 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 ESL11275.1 - 0.00059 20.3 0.5 0.011 16.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11275.1 - 0.0016 18.0 0.0 0.0031 17.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain HD PF01966.17 ESL11275.1 - 0.061 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 HD domain EF1G PF00647.14 ESL11276.1 - 1.6e-47 159.6 0.0 6.8e-47 157.6 0.1 1.9 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 ESL11276.1 - 9.6e-15 54.3 0.7 1.9e-14 53.3 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESL11276.1 - 6.7e-11 42.2 0.0 1.7e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESL11276.1 - 1.8e-06 28.3 1.0 3.1e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESL11276.1 - 3.2e-06 27.2 0.0 6.9e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESL11276.1 - 2.7e-05 23.9 0.3 2.7e-05 23.9 0.2 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESL11276.1 - 0.0064 16.4 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Histone PF00125.19 ESL11277.1 - 9.5e-19 67.3 0.1 1.4e-18 66.7 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Lipase_3 PF01764.20 ESL11278.1 - 4.4e-39 133.3 0.0 6.2e-39 132.8 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESL11278.1 - 0.00017 21.0 0.0 0.0026 17.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.2 ESL11278.1 - 0.004 17.0 0.3 0.0073 16.2 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL11278.1 - 0.037 13.7 0.1 0.085 12.6 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF2048 PF09752.4 ESL11278.1 - 0.038 12.8 0.0 0.064 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) DGF-1_C PF11040.3 ESL11279.1 - 1.5e-07 31.2 0.1 3.4e-07 30.0 0.0 1.6 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus CCDC92 PF14916.1 ESL11280.1 - 0.00084 18.8 0.3 0.00084 18.8 0.2 2.0 2 0 0 2 2 2 1 Coiled-coil domain of unknown function Viral_P18 PF04521.8 ESL11280.1 - 0.44 9.9 3.2 18 4.7 1.1 2.6 2 1 1 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein BCDHK_Adom3 PF10436.4 ESL11281.1 - 3.6e-33 114.3 0.1 6.8e-33 113.4 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESL11281.1 - 3.6e-06 26.6 0.0 7.3e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESL11281.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1877 PF08974.5 ESL11281.1 - 0.038 13.6 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) Spt5-NGN PF03439.8 ESL11283.1 - 8.8e-19 67.0 0.1 2.9e-18 65.4 0.0 2.0 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.24 ESL11283.1 - 2.4e-06 27.0 3.1 0.013 15.2 0.6 3.9 4 0 0 4 4 4 2 KOW motif Spt5_N PF11942.3 ESL11283.1 - 0.00079 19.9 4.7 0.00085 19.8 0.1 2.4 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal GTP1_OBG PF01018.17 ESL11284.1 - 2.7e-35 121.3 6.9 3.8e-35 120.8 4.8 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.18 ESL11284.1 - 9.2e-17 61.0 0.0 1.5e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL11284.1 - 4e-06 26.1 0.0 4.4e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESL11284.1 - 0.16 11.7 0.0 5.6 6.7 0.0 2.2 1 1 1 2 2 2 0 Dynamin family Arf PF00025.16 ESL11284.1 - 0.2 10.8 0.0 2.1 7.5 0.0 2.3 2 1 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL11284.1 - 0.2 11.0 0.0 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Ribosomal_S26e PF01283.14 ESL11285.1 - 1.3e-40 138.1 3.6 1.4e-40 138.0 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e IF2_assoc PF08364.6 ESL11285.1 - 0.91 9.5 7.7 1.2 9.2 0.3 2.3 2 0 0 2 2 2 0 Bacterial translation initiation factor IF-2 associated region Glyoxalase PF00903.20 ESL11288.1 - 5e-17 62.0 0.1 9.5e-17 61.1 0.0 1.5 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 ESL11288.1 - 4e-15 56.3 0.1 5.1e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 ESL11288.1 - 8.1e-12 45.1 0.0 1.5e-11 44.2 0.0 1.4 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.1 ESL11288.1 - 0.00036 20.2 0.0 0.00043 19.9 0.0 1.1 1 0 0 1 1 1 1 CppA N-terminal Tmemb_185A PF10269.4 ESL11290.1 - 0.0032 17.1 22.8 0.015 14.8 6.9 2.2 1 1 1 2 2 2 2 Transmembrane Fragile-X-F protein DUF3593 PF12159.3 ESL11290.1 - 0.065 13.0 5.6 0.063 13.0 1.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3593) PalH PF08733.5 ESL11290.1 - 0.077 11.8 5.0 0.017 14.0 1.1 1.5 2 0 0 2 2 2 0 PalH/RIM21 CD20 PF04103.10 ESL11290.1 - 0.17 11.8 8.6 0.79 9.6 6.0 2.0 1 1 0 1 1 1 0 CD20-like family DUF373 PF04123.8 ESL11290.1 - 0.4 9.6 13.0 0.21 10.6 6.7 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF373) DUF805 PF05656.9 ESL11290.1 - 0.46 10.3 16.6 0.076 12.8 6.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF805) DUF3357 PF11837.3 ESL11290.1 - 8.9 6.2 8.1 17 5.2 0.6 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF3357) Ribonuclease_3 PF00636.21 ESL11292.1 - 9.8e-05 22.7 0.0 0.00045 20.6 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain Mito_fiss_reg PF05308.6 ESL11293.1 - 0.31 10.3 1.4 0.34 10.2 1.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Ax_dynein_light PF10211.4 ESL11294.1 - 9e-80 266.9 9.8 1.3e-79 266.4 6.8 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain ERM PF00769.14 ESL11294.1 - 8.3e-05 22.2 9.9 0.00015 21.3 6.8 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family APG6 PF04111.7 ESL11294.1 - 0.0015 17.6 6.3 0.0023 17.0 4.4 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 IncA PF04156.9 ESL11294.1 - 0.012 15.2 12.5 0.012 15.2 8.7 2.0 1 1 1 2 2 2 0 IncA protein CENP-F_leu_zip PF10473.4 ESL11294.1 - 0.013 15.4 10.7 0.013 15.4 7.4 1.7 2 0 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin-6_N PF09177.6 ESL11294.1 - 0.017 15.4 4.8 0.048 14.0 3.3 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF3373 PF11853.3 ESL11294.1 - 0.018 13.6 1.4 0.023 13.2 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Spc7 PF08317.6 ESL11294.1 - 0.018 13.7 6.0 0.025 13.2 4.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc24 PF08286.6 ESL11294.1 - 0.032 13.9 6.1 0.058 13.0 4.3 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Allexi_40kDa PF05549.6 ESL11294.1 - 0.034 13.4 0.4 0.05 12.8 0.3 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein OmpH PF03938.9 ESL11294.1 - 0.039 13.8 8.4 0.082 12.8 5.9 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TBPIP PF07106.8 ESL11294.1 - 0.051 13.1 3.8 0.1 12.1 2.6 1.6 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Prefoldin PF02996.12 ESL11294.1 - 0.11 12.1 5.1 5.7 6.6 0.2 2.6 1 1 1 2 2 2 0 Prefoldin subunit Mnd1 PF03962.10 ESL11294.1 - 0.13 11.9 9.0 0.24 11.0 6.2 1.4 1 0 0 1 1 1 0 Mnd1 family Atg14 PF10186.4 ESL11294.1 - 0.28 10.0 6.9 0.43 9.4 4.8 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CtIP_N PF10482.4 ESL11294.1 - 0.3 10.8 10.2 0.49 10.2 3.9 2.3 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain L_lactis_ph-MCP PF06673.6 ESL11294.1 - 0.3 9.8 4.1 0.46 9.1 2.8 1.2 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein DivIC PF04977.10 ESL11294.1 - 0.31 10.5 10.3 0.029 13.8 3.5 2.0 2 1 0 2 2 1 0 Septum formation initiator Nsp1_C PF05064.8 ESL11294.1 - 0.31 10.7 4.6 0.73 9.4 3.2 1.6 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF342 PF03961.8 ESL11294.1 - 0.37 9.1 3.7 0.58 8.5 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 ESL11294.1 - 1.4 6.6 3.9 1.8 6.3 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.1 ESL11294.1 - 4.8 7.0 7.4 8.9 6.1 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4164 PF13747.1 ESL11294.1 - 6.9 6.8 17.1 1.8 8.7 7.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) DUF947 PF06102.7 ESL11294.1 - 9 6.0 14.8 0.62 9.8 6.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF947) DNA_ligase_A_M PF01068.16 ESL11296.1 - 1.9e-53 180.8 0.0 3.1e-53 180.1 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 ESL11296.1 - 1.3e-39 135.8 0.3 4e-39 134.2 0.1 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 ESL11296.1 - 1.3e-26 92.8 0.0 7.2e-26 90.4 0.0 2.3 3 0 0 3 3 3 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 ESL11296.1 - 0.0009 18.8 1.0 0.27 10.9 0.1 2.5 2 0 0 2 2 2 2 DNA ligase OB-like domain mRNA_cap_enzyme PF01331.14 ESL11296.1 - 0.12 12.0 0.0 0.91 9.1 0.0 2.0 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain Mog1 PF04603.7 ESL11297.1 - 1.8e-26 92.7 0.0 9.4e-26 90.4 0.0 1.9 1 1 0 1 1 1 1 Ran-interacting Mog1 protein AAA PF00004.24 ESL11298.1 - 2.3e-43 147.5 0.0 5.4e-43 146.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL11298.1 - 4.9e-07 29.5 0.0 2.2e-06 27.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL11298.1 - 6.9e-07 29.4 0.1 2.7e-06 27.4 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 ESL11298.1 - 2.4e-06 27.5 0.0 6e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL11298.1 - 1.7e-05 25.0 0.2 0.00055 20.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL11298.1 - 3.2e-05 23.0 0.0 8.2e-05 21.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESL11298.1 - 4.3e-05 23.1 0.1 0.00015 21.4 0.1 1.9 2 0 0 2 2 1 1 Part of AAA domain AAA_17 PF13207.1 ESL11298.1 - 0.00012 22.8 0.1 0.00045 21.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESL11298.1 - 0.00034 20.0 0.0 0.00076 18.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESL11298.1 - 0.00065 19.6 0.0 0.0038 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 ESL11298.1 - 0.00075 18.6 0.4 0.069 12.2 0.0 2.6 3 0 0 3 3 3 1 KaiC AAA_33 PF13671.1 ESL11298.1 - 0.0012 18.7 0.3 0.0044 16.8 0.0 2.0 2 1 1 3 3 2 1 AAA domain AAA_28 PF13521.1 ESL11298.1 - 0.003 17.5 0.0 0.0069 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESL11298.1 - 0.0033 16.2 0.0 0.01 14.6 0.0 1.8 2 0 0 2 2 2 1 TIP49 C-terminus Zeta_toxin PF06414.7 ESL11298.1 - 0.0039 16.3 0.1 0.01 14.9 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_3 PF07726.6 ESL11298.1 - 0.0042 16.6 0.0 0.019 14.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ESL11298.1 - 0.0047 16.9 0.1 0.11 12.5 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain Mg_chelatase PF01078.16 ESL11298.1 - 0.0052 15.9 0.0 0.013 14.6 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 ESL11298.1 - 0.007 15.6 0.1 0.063 12.5 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_25 PF13481.1 ESL11298.1 - 0.0089 15.4 0.5 0.11 11.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESL11298.1 - 0.0091 16.3 0.0 0.026 14.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 ESL11298.1 - 0.011 15.2 0.1 0.054 12.9 0.0 2.3 2 1 0 2 2 1 0 Sigma-54 interaction domain RNA_helicase PF00910.17 ESL11298.1 - 0.012 15.7 0.0 0.029 14.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 ESL11298.1 - 0.013 15.0 0.0 0.04 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESL11298.1 - 0.021 13.7 0.0 0.061 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.7 ESL11298.1 - 0.024 14.2 0.2 0.56 9.8 0.0 3.0 2 2 2 4 4 4 0 NACHT domain CENP-F_leu_zip PF10473.4 ESL11298.1 - 0.027 14.3 1.8 0.087 12.6 0.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Parvo_NS1 PF01057.12 ESL11298.1 - 0.035 12.9 0.2 0.086 11.6 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ATP-synt_F6 PF05511.6 ESL11298.1 - 0.035 13.9 0.1 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 AAA_30 PF13604.1 ESL11298.1 - 0.062 12.8 0.0 0.52 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 ESL11298.1 - 0.063 12.8 0.6 0.31 10.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 ESL11298.1 - 0.49 10.0 6.0 2.9 7.5 0.0 3.5 3 1 1 4 4 4 0 NTPase Helicase_C_2 PF13307.1 ESL11299.1 - 8e-40 136.5 0.0 1.3e-39 135.7 0.0 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain DUF1227 PF06777.6 ESL11299.1 - 0.0031 17.2 0.2 0.0052 16.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) Ku PF02735.11 ESL11300.1 - 3.6e-22 78.7 0.0 6e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.6 ESL11300.1 - 1.2e-18 67.1 0.0 2.9e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.10 ESL11300.1 - 2.9e-05 23.6 0.0 4.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA_2 PF13519.1 ESL11300.1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Ku_C PF03730.9 ESL11300.1 - 0.14 12.6 0.2 0.54 10.8 0.0 2.1 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm FA_hydroxylase PF04116.8 ESL11301.1 - 3.2e-13 50.0 26.9 3.2e-13 50.0 18.6 2.3 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily BSP_II PF05432.6 ESL11302.1 - 0.0014 17.9 8.8 0.0028 16.9 6.1 1.4 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) BBP1_C PF15272.1 ESL11302.1 - 0.0085 15.6 13.2 0.0085 15.6 9.1 4.3 1 1 3 4 4 4 1 Spindle pole body component BBP1, C-terminal TMF_TATA_bd PF12325.3 ESL11302.1 - 0.014 15.0 2.8 0.014 15.0 1.9 6.6 3 1 4 8 8 8 0 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.7 ESL11302.1 - 0.069 12.8 0.2 0.069 12.8 0.1 5.9 3 1 3 6 6 6 0 TPR/MLP1/MLP2-like protein Filament PF00038.16 ESL11302.1 - 0.44 9.9 57.6 0.17 11.3 7.5 3.4 1 1 1 2 2 2 0 Intermediate filament protein Reo_sigmaC PF04582.7 ESL11302.1 - 1.9 7.5 12.9 0.83 8.7 3.8 2.5 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Fic PF02661.13 ESL11302.1 - 6.1 7.6 9.2 5.5 7.7 0.2 4.0 3 2 1 4 4 4 0 Fic/DOC family Pkinase PF00069.20 ESL11303.1 - 6.1e-59 199.2 0.0 7.8e-59 198.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11303.1 - 4.1e-28 98.1 0.0 8.1e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESL11303.1 - 9.6e-06 24.7 0.6 1.8e-05 23.9 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESL11303.1 - 4.2e-05 23.4 0.3 8.5e-05 22.3 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family CheR PF01739.13 ESL11303.1 - 0.0066 15.7 0.0 0.016 14.4 0.0 1.7 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain RIO1 PF01163.17 ESL11303.1 - 0.073 12.4 0.5 0.16 11.3 0.3 1.6 1 0 0 1 1 1 0 RIO1 family WaaY PF06176.6 ESL11303.1 - 0.085 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) FYVE PF01363.16 ESL11304.1 - 0.015 15.2 17.6 0.044 13.6 12.2 1.9 1 0 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.11 ESL11304.1 - 0.044 13.6 11.7 0.1 12.5 8.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Miro PF08477.8 ESL11305.1 - 6.5e-07 29.8 0.0 1.1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 ESL11305.1 - 0.0019 17.5 0.0 0.037 13.4 0.0 2.1 2 0 0 2 2 2 1 Ras family AAA_16 PF13191.1 ESL11305.1 - 0.0033 17.4 0.0 0.0071 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESL11305.1 - 0.0081 16.2 0.0 0.025 14.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 ESL11305.1 - 0.0086 15.7 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Sigma54_activat PF00158.21 ESL11305.1 - 0.018 14.4 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.9 ESL11305.1 - 0.07 12.8 0.0 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DAP3 PF10236.4 ESL11305.1 - 0.076 11.9 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MobB PF03205.9 ESL11305.1 - 0.092 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 ESL11305.1 - 0.15 12.3 0.0 2.2 8.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter YceI PF04264.8 ESL11306.1 - 3.5e-07 30.3 0.0 3.8e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 YceI-like domain DnaJ PF00226.26 ESL11307.1 - 2.5e-13 49.5 0.0 5.3e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain UVR PF02151.14 ESL11307.1 - 0.72 9.4 3.5 0.36 10.4 0.5 2.0 2 0 0 2 2 2 0 UvrB/uvrC motif YWFCY PF14293.1 ESL11307.1 - 2.4 8.0 8.4 3.2 7.6 0.6 3.6 3 0 0 3 3 3 0 YWFCY protein AAA PF00004.24 ESL11308.1 - 1.7e-09 37.9 0.0 9.4e-09 35.5 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL11308.1 - 8.3e-07 29.2 0.0 2.3e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESL11308.1 - 5.3e-06 27.2 0.0 1.8e-05 25.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL11308.1 - 1.4e-05 24.7 0.7 8.1e-05 22.2 0.5 2.4 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 ESL11308.1 - 2.6e-05 23.9 0.0 5.9e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESL11308.1 - 5.5e-05 23.0 0.0 0.00014 21.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESL11308.1 - 0.00018 21.5 0.0 0.00048 20.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 ESL11308.1 - 0.00041 19.1 0.0 0.18 10.4 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 ESL11308.1 - 0.00053 20.0 0.3 0.0038 17.2 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.1 ESL11308.1 - 0.00064 20.0 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL11308.1 - 0.00064 18.8 0.0 0.0013 17.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESL11308.1 - 0.00076 18.9 0.0 0.0021 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESL11308.1 - 0.0034 16.5 0.0 0.0067 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 ESL11308.1 - 0.004 16.7 0.0 0.011 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESL11308.1 - 0.026 13.9 0.0 0.069 12.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 ESL11308.1 - 0.027 14.1 0.1 0.15 11.7 0.0 2.3 3 0 0 3 3 2 0 NACHT domain ABC_tran PF00005.22 ESL11308.1 - 0.028 14.7 0.0 0.074 13.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.7 ESL11308.1 - 0.033 13.2 0.1 0.064 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Polyoma_lg_T_C PF06431.6 ESL11308.1 - 0.046 12.3 0.0 0.071 11.7 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus SKI PF01202.17 ESL11308.1 - 0.049 13.4 0.0 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase RNA_helicase PF00910.17 ESL11308.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 ESL11308.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.1 ESL11308.1 - 0.13 12.1 0.0 0.3 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESL11308.1 - 0.27 10.8 0.0 0.48 9.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESL11309.1 - 1.9e-06 27.9 5.4 0.0011 18.9 0.1 2.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 ESL11309.1 - 0.0004 20.5 0.6 0.21 11.7 0.1 2.6 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 ESL11309.1 - 0.0092 15.7 0.0 0.87 9.2 0.0 2.4 2 0 0 2 2 2 2 Archaeal ATPase DUF521 PF04412.8 ESL11310.1 - 0.085 11.3 0.0 0.11 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) RseA_C PF03873.8 ESL11311.1 - 0.12 12.2 1.0 0.31 10.9 0.7 1.7 1 1 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain MFS_1 PF07690.11 ESL11312.1 - 1.3e-15 57.0 5.5 1.7e-15 56.6 3.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1049 PF06305.6 ESL11312.1 - 1.2 8.6 7.1 41 3.7 1.0 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1049) GTP_EFTU PF00009.22 ESL11314.1 - 4.2e-43 146.9 0.6 1e-42 145.7 0.0 1.9 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESL11314.1 - 1.5e-18 66.7 0.1 3.9e-18 65.4 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.18 ESL11314.1 - 0.0001 22.2 0.0 0.0003 20.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESL11314.1 - 0.0037 17.3 0.1 0.04 14.0 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 G-alpha PF00503.15 ESL11314.1 - 0.16 10.6 2.0 0.24 10.0 1.4 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Ribosomal_S8 PF00410.14 ESL11315.1 - 2.8e-23 82.1 0.0 3.9e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 ThiF PF00899.16 ESL11316.1 - 2.9e-36 124.2 0.1 4.5e-36 123.6 0.1 1.3 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 ESL11316.1 - 9.5e-14 50.7 0.0 1.6e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ESL11316.1 - 7.7e-08 31.5 0.1 1.7e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 ESL11316.1 - 0.0035 17.4 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 ESL11316.1 - 0.068 12.1 0.2 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase Pyr_redox PF00070.22 ESL11316.1 - 0.11 12.8 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ARL2_Bind_BART PF11527.3 ESL11318.1 - 0.00011 21.9 0.0 0.00015 21.5 0.0 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Methyltransf_5 PF01795.14 ESL11319.1 - 5.1e-30 104.8 0.0 7.4e-30 104.2 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family Methyltransf_26 PF13659.1 ESL11319.1 - 1.1e-06 28.7 0.3 9.9e-06 25.5 0.2 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11319.1 - 7.1e-06 25.6 0.0 0.00037 20.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.1 ESL11319.1 - 0.0007 20.4 0.0 0.0021 18.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL11319.1 - 0.0012 19.3 0.1 0.041 14.4 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESL11319.1 - 0.13 11.6 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain MHC_II_alpha PF00993.15 ESL11320.1 - 0.12 11.9 0.0 0.43 10.1 0.0 1.9 2 0 0 2 2 2 0 Class II histocompatibility antigen, alpha domain Complex1_51K PF01512.12 ESL11322.1 - 2e-45 154.1 0.0 3.5e-45 153.4 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 ESL11322.1 - 4.4e-19 67.3 0.1 8.2e-19 66.4 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 ESL11322.1 - 2e-08 34.0 0.0 5.2e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 SLBB domain DUF780 PF05611.6 ESL11322.1 - 0.013 16.1 3.2 0.03 15.0 2.2 1.5 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF780) PAP_assoc PF03828.14 ESL11324.1 - 4e-05 23.4 0.0 0.00015 21.6 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase Arf PF00025.16 ESL11325.1 - 3.8e-58 195.5 0.0 4.3e-58 195.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 ESL11325.1 - 8.2e-10 39.2 0.0 1.1e-09 38.8 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 ESL11325.1 - 6.6e-09 34.9 0.4 2e-06 26.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 ESL11325.1 - 1.1e-08 34.5 0.0 1.4e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 ESL11325.1 - 1.2e-08 34.5 0.0 1.4e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 ESL11325.1 - 6.3e-07 29.3 0.0 9.4e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL11325.1 - 3.8e-06 26.4 0.2 0.0016 17.9 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESL11325.1 - 9.9e-05 21.5 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.13 ESL11325.1 - 0.0011 18.2 0.1 0.0092 15.2 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B cobW PF02492.14 ESL11325.1 - 0.013 14.9 0.1 0.86 9.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 ESL11325.1 - 0.024 14.1 0.0 0.06 12.8 0.0 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.17 ESL11325.1 - 0.032 13.6 0.1 0.058 12.8 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.1 ESL11325.1 - 0.034 14.1 0.1 0.38 10.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain MIF4G PF02854.14 ESL11326.1 - 7.4e-31 107.1 2.1 1.2e-30 106.5 1.5 1.3 1 0 0 1 1 1 1 MIF4G domain Dynein_light PF01221.13 ESL11327.1 - 2.3e-16 59.5 0.0 5.2e-15 55.1 0.0 2.1 2 0 0 2 2 2 1 Dynein light chain type 1 Ground-like PF04155.13 ESL11327.1 - 8.9e-08 32.3 0.0 1.6e-07 31.4 0.0 1.6 1 1 0 1 1 1 1 Ground-like domain XPC-binding PF09280.6 ESL11328.1 - 0.28 10.6 3.3 3.9 7.0 0.2 3.3 3 0 0 3 3 3 0 XPC-binding domain His_Phos_1 PF00300.17 ESL11329.1 - 1e-17 64.6 0.0 1.5e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) IncA PF04156.9 ESL11331.1 - 7.3 6.1 7.5 0.39 10.3 1.2 1.7 2 1 0 2 2 2 0 IncA protein Yip1 PF04893.12 ESL11332.1 - 4.7e-15 55.5 21.2 6.3e-15 55.0 14.7 1.3 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.7 ESL11332.1 - 0.00035 20.2 12.9 0.00052 19.7 9.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1282) BRI3BP PF14965.1 ESL11332.1 - 0.23 10.8 10.2 0.4 10.0 7.1 1.4 1 0 0 1 1 1 0 Negative regulator of p53/TP53 LRR_4 PF12799.2 ESL11333.1 - 8.5e-17 60.3 3.5 1.2e-05 24.7 0.1 4.9 2 2 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL11333.1 - 3.6e-12 45.8 10.4 6e-06 25.9 1.6 3.8 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESL11333.1 - 4.7e-11 41.1 3.0 3.8 7.9 0.0 6.7 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 ESL11333.1 - 3.8e-07 29.2 5.4 5.5 7.6 0.0 7.0 6 1 0 6 6 6 1 Leucine rich repeat LRR_6 PF13516.1 ESL11333.1 - 9e-05 22.1 13.6 0.54 10.4 0.2 6.6 5 2 2 7 7 7 2 Leucine Rich repeat EzrA PF06160.7 ESL11333.1 - 0.0087 14.2 2.8 0.014 13.6 2.0 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA LRR_9 PF14580.1 ESL11333.1 - 0.022 14.3 0.3 1.4 8.4 0.0 2.6 2 1 1 3 3 3 0 Leucine-rich repeat XhlA PF10779.4 ESL11333.1 - 0.45 10.4 2.6 0.35 10.7 0.5 1.8 2 0 0 2 2 2 0 Haemolysin XhlA YscO PF07321.7 ESL11333.1 - 0.71 9.6 14.0 0.13 12.0 0.4 2.6 2 1 0 2 2 2 0 Type III secretion protein YscO TPR_MLP1_2 PF07926.7 ESL11333.1 - 0.77 9.5 7.3 0.95 9.2 1.0 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.1 ESL11333.1 - 0.95 9.4 8.9 0.065 13.1 2.7 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) EMP24_GP25L PF01105.19 ESL11333.1 - 2.4 7.8 4.4 15 5.2 0.0 2.2 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD IncA PF04156.9 ESL11333.1 - 5.5 6.5 11.7 11 5.6 8.1 1.5 1 0 0 1 1 1 0 IncA protein UQ_con PF00179.21 ESL11334.1 - 3.4e-45 152.9 0.0 4e-45 152.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ESL11334.1 - 0.00059 19.5 0.0 0.0011 18.6 0.0 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 ESL11334.1 - 0.0012 18.6 0.0 0.0016 18.3 0.0 1.4 1 1 0 1 1 1 1 RWD domain Isochorismatase PF00857.15 ESL11335.1 - 4.3e-15 56.0 0.1 1.3e-14 54.5 0.1 1.7 1 1 0 1 1 1 1 Isochorismatase family GPS PF01825.16 ESL11335.1 - 0.029 14.4 0.1 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 Latrophilin/CL-1-like GPS domain Kinesin PF00225.18 ESL11336.1 - 2e-88 296.3 0.0 3.6e-88 295.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain ADP_ribosyl_GH PF03747.9 ESL11337.1 - 1.1e-09 38.4 2.6 1.5e-06 28.1 0.0 3.3 3 1 0 3 3 3 2 ADP-ribosylglycohydrolase SprA-related PF12118.3 ESL11337.1 - 0.19 11.0 0.4 0.31 10.3 0.3 1.2 1 0 0 1 1 1 0 SprA-related family PIP5K PF01504.13 ESL11338.1 - 2.6e-59 200.3 0.0 4.6e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase FAD-oxidase_C PF02913.14 ESL11339.1 - 9.2e-53 179.1 0.0 1.5e-52 178.4 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 ESL11339.1 - 2.5e-37 127.4 0.0 4.7e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Sec2p PF06428.6 ESL11340.1 - 1.2 8.9 32.9 0.12 12.2 2.2 4.4 3 1 1 4 4 4 0 GDP/GTP exchange factor Sec2p CLASP_N PF12348.3 ESL11341.1 - 6e-20 71.5 0.9 1.4e-16 60.5 0.0 2.8 2 1 1 3 3 3 2 CLASP N terminal HEAT_2 PF13646.1 ESL11341.1 - 9.1e-05 22.6 12.9 0.44 10.8 0.1 5.8 5 1 0 5 5 5 3 HEAT repeats Cnd1 PF12717.2 ESL11341.1 - 0.0049 16.7 1.6 0.16 11.8 0.1 3.3 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.1 ESL11341.1 - 0.016 15.1 0.1 0.052 13.5 0.1 1.9 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain VHS PF00790.14 ESL11341.1 - 0.042 13.4 0.2 0.11 12.1 0.2 1.7 1 0 0 1 1 1 0 VHS domain HEAT PF02985.17 ESL11341.1 - 1.5 9.0 14.2 3.9 7.8 0.0 6.1 6 0 0 6 6 6 0 HEAT repeat tRNA-synt_1 PF00133.17 ESL11342.1 - 6.6e-17 60.7 0.1 5.1e-15 54.4 0.0 2.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESL11342.1 - 6.9e-12 45.3 0.0 1.9e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESL11342.1 - 9.5e-11 40.9 0.0 2.7e-10 39.4 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 ESL11342.1 - 1.4e-06 27.6 0.0 2.5e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Lyase_1 PF00206.15 ESL11344.1 - 1.5e-50 172.1 0.0 2e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.6 ESL11344.1 - 3.8e-44 149.2 0.0 6.6e-44 148.4 0.0 1.4 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal CLASP_N PF12348.3 ESL11345.1 - 0.075 12.3 0.0 13 5.0 0.0 3.5 3 1 1 4 4 4 0 CLASP N terminal Voldacs PF03517.8 ESL11345.1 - 0.082 12.7 1.2 2 8.2 0.3 2.4 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling Ala_racemase_N PF01168.15 ESL11346.1 - 5.6e-44 150.2 0.0 6.8e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Sec10 PF07393.6 ESL11346.1 - 0.0073 14.5 0.0 0.0094 14.1 0.0 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 Ribosomal_L1 PF00687.16 ESL11346.1 - 0.057 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L1p/L10e family Pkinase PF00069.20 ESL11347.1 - 3.3e-49 167.3 0.0 4.1e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11347.1 - 3.5e-28 98.3 0.0 4.3e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Crp PF00325.15 ESL11349.1 - 0.15 11.5 2.2 0.25 10.8 0.6 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family COPIIcoated_ERV PF07970.7 ESL11350.1 - 7.2e-41 140.2 0.0 1.6e-40 139.0 0.0 1.5 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 ESL11350.1 - 1.6e-25 88.8 0.0 2.9e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) MobB PF03205.9 ESL11351.1 - 5.2e-08 32.6 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Clp1 PF06807.9 ESL11351.1 - 0.0013 18.5 0.0 0.13 11.9 0.0 2.5 2 0 0 2 2 2 2 Pre-mRNA cleavage complex II protein Clp1 Cep57_CLD_2 PF14197.1 ESL11352.1 - 0.011 15.6 0.8 0.011 15.6 0.5 3.0 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Atg14 PF10186.4 ESL11352.1 - 0.027 13.4 17.0 0.034 13.0 11.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 YojJ PF10372.4 ESL11352.1 - 0.057 13.2 0.6 0.22 11.4 0.0 2.2 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus Chloroa_b-bind PF00504.16 ESL11352.1 - 0.1 12.8 0.6 0.14 12.4 0.4 1.3 1 1 0 1 1 1 0 Chlorophyll A-B binding protein IncA PF04156.9 ESL11352.1 - 0.23 11.0 21.3 0.84 9.2 9.7 2.1 2 0 0 2 2 2 0 IncA protein EzrA PF06160.7 ESL11352.1 - 0.26 9.4 12.4 0.53 8.4 8.6 1.5 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Sec8_exocyst PF04048.9 ESL11352.1 - 0.28 10.7 4.7 2.2 7.8 0.0 2.8 2 1 0 3 3 3 0 Sec8 exocyst complex component specific domain Occludin_ELL PF07303.8 ESL11352.1 - 1.1 9.9 11.1 0.59 10.8 0.4 2.5 1 1 1 2 2 2 0 Occludin homology domain DUF2730 PF10805.3 ESL11352.1 - 1.3 8.8 9.5 0.69 9.6 0.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) GAS PF13851.1 ESL11352.1 - 1.6 7.8 19.8 0.77 8.9 1.3 2.4 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding BAR_2 PF10455.4 ESL11352.1 - 1.7 7.4 6.4 0.81 8.5 2.1 1.9 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Fib_alpha PF08702.5 ESL11352.1 - 2.2 8.3 6.6 4.7 7.3 2.2 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Mnd1 PF03962.10 ESL11352.1 - 2.8 7.5 15.9 9.2 5.8 0.3 2.1 2 0 0 2 2 2 0 Mnd1 family DUF4404 PF14357.1 ESL11352.1 - 8.1 6.9 15.0 9.3 6.7 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) Arf PF00025.16 ESL11353.1 - 6.2e-57 191.6 0.1 6.8e-57 191.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESL11353.1 - 2.6e-12 46.3 0.0 3.1e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 ESL11353.1 - 8.5e-11 41.1 0.1 8.3e-10 37.9 0.0 2.0 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.7 ESL11353.1 - 3e-10 39.6 0.0 3.2e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 ESL11353.1 - 2.4e-08 33.5 0.0 3.2e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL11353.1 - 6.3e-08 33.1 0.0 8.6e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESL11353.1 - 2e-06 27.7 0.0 2.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESL11353.1 - 2.6e-05 23.7 0.1 0.00065 19.1 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 ESL11353.1 - 0.055 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 ESL11353.1 - 0.056 12.7 0.0 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B 6PF2K PF01591.13 ESL11353.1 - 0.083 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase PPR PF01535.15 ESL11354.1 - 0.00037 20.2 0.0 1 9.4 0.0 4.6 4 0 0 4 4 4 1 PPR repeat PPR_3 PF13812.1 ESL11354.1 - 0.0039 17.3 1.5 1.2 9.6 0.1 4.2 3 0 0 3 3 3 1 Pentatricopeptide repeat domain Apc3 PF12895.2 ESL11354.1 - 0.0094 16.0 0.0 0.029 14.4 0.0 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 PPR_2 PF13041.1 ESL11354.1 - 0.021 14.7 0.0 2.4 8.2 0.0 3.6 3 1 1 4 4 4 0 PPR repeat family DUF2285 PF10074.4 ESL11354.1 - 0.062 13.6 0.1 0.062 13.6 0.1 3.0 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2285) HA PF03457.9 ESL11354.1 - 0.13 12.3 2.6 3.3 7.8 0.0 3.7 3 0 0 3 3 3 0 Helicase associated domain PSK_trans_fac PF07704.6 ESL11354.1 - 1.1 10.0 9.1 2.5 8.8 0.2 3.7 3 1 0 3 3 3 0 Rv0623-like transcription factor PSP1 PF04468.7 ESL11356.1 - 1.3e-29 101.9 0.2 2e-29 101.3 0.2 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Sld5 PF05916.6 ESL11357.1 - 0.099 12.9 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 GINS complex protein MMS19_N PF14500.1 ESL11358.1 - 7.1e-25 87.7 0.1 7.1e-25 87.7 0.0 3.3 4 1 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Cnd1 PF12717.2 ESL11358.1 - 0.015 15.1 0.1 0.67 9.7 0.0 3.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 PFK PF00365.15 ESL11358.1 - 0.099 11.5 0.1 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphofructokinase ThiF PF00899.16 ESL11359.1 - 3e-08 33.5 0.4 5.2e-08 32.8 0.3 1.4 1 0 0 1 1 1 1 ThiF family Cpn60_TCP1 PF00118.19 ESL11360.1 - 0.0062 15.2 0.0 0.0086 14.7 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CTP_transf_2 PF01467.21 ESL11361.1 - 1.2e-11 44.9 0.1 2.9e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase CDP-OH_P_transf PF01066.16 ESL11361.1 - 1.2e-07 31.9 0.5 1.2e-07 31.9 0.3 3.0 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase DUF1408 PF07193.6 ESL11361.1 - 0.014 14.8 0.0 0.069 12.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1408) FAD_syn PF06574.7 ESL11361.1 - 0.022 14.4 1.7 1.4 8.5 0.1 3.5 4 0 0 4 4 4 0 FAD synthetase SNF2_N PF00176.18 ESL11362.1 - 3.6e-78 262.4 1.1 4.8e-78 261.9 0.1 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.5 ESL11362.1 - 4.8e-24 84.3 1.1 1.2e-23 83.0 0.8 1.8 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.26 ESL11362.1 - 2.1e-16 59.5 0.0 6.4e-16 57.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESL11362.1 - 5.4e-06 26.0 0.0 1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESL11362.1 - 1.2e-05 25.2 0.0 5e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit HAND PF09110.6 ESL11362.1 - 0.00013 22.2 2.6 0.00023 21.5 0.7 2.3 2 0 0 2 2 2 1 HAND RRM_5 PF13893.1 ESL11362.1 - 0.076 12.8 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TT_ORF2 PF02957.10 ESL11362.1 - 1.6 9.4 4.5 7.8 7.2 0.3 2.7 2 0 0 2 2 2 0 TT viral ORF2 LRR_6 PF13516.1 ESL11365.1 - 3.6e-20 69.7 4.2 0.025 14.5 0.0 9.2 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.2 ESL11365.1 - 8.6e-17 60.3 4.0 0.0025 17.3 0.0 7.2 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESL11365.1 - 1.3e-12 45.8 12.3 0.11 12.6 0.1 9.0 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_8 PF13855.1 ESL11365.1 - 1.7e-10 40.4 13.0 0.019 14.7 0.0 6.4 4 2 1 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 ESL11365.1 - 4.2e-09 35.1 21.7 0.63 10.4 0.0 9.4 10 0 0 10 10 10 5 Leucine rich repeat ERG2_Sigma1R PF04622.7 ESL11367.1 - 7.6e-66 221.4 0.3 8.3e-66 221.3 0.2 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein SPA PF08616.5 ESL11368.1 - 1.5e-27 95.5 0.0 2.6e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.7 ESL11368.1 - 3e-10 40.2 0.0 5.2e-08 33.0 0.0 2.3 2 0 0 2 2 2 2 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2347 PF09804.4 ESL11368.1 - 0.008 15.4 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) RPT PF13446.1 ESL11369.1 - 0.13 11.7 0.1 0.28 10.6 0.1 1.6 1 0 0 1 1 1 0 A repeated domain in UCH-protein Proteasome PF00227.21 ESL11371.1 - 2e-51 174.0 0.0 2.6e-51 173.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESL11371.1 - 8.3e-13 47.3 0.5 1.4e-12 46.6 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ComC PF03047.9 ESL11371.1 - 0.014 14.7 0.6 0.026 13.9 0.4 1.4 1 0 0 1 1 1 0 COMC family HTH_3 PF01381.17 ESL11371.1 - 0.049 13.4 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix SH3_9 PF14604.1 ESL11372.1 - 2e-33 113.7 7.0 4.7e-14 51.6 0.1 4.5 4 1 0 4 4 4 3 Variant SH3 domain SH3_1 PF00018.23 ESL11372.1 - 4.8e-31 105.9 0.6 3.1e-11 42.4 0.1 3.5 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.12 ESL11372.1 - 2.2e-28 97.5 2.6 2.9e-09 36.2 0.2 3.4 3 0 0 3 3 3 3 Variant SH3 domain zf-TFIIIC PF12660.2 ESL11372.1 - 0.22 11.4 2.6 0.17 11.8 0.3 1.8 2 0 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex TTL PF03133.10 ESL11373.1 - 3.9e-52 177.0 0.0 5.1e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESL11373.1 - 0.00031 20.5 0.0 0.00093 18.9 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 ESL11373.1 - 0.00034 19.5 0.0 0.33 9.7 0.0 2.6 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.9 ESL11373.1 - 0.011 15.5 0.0 0.96 9.2 0.0 2.8 3 0 0 3 3 3 0 ATP-grasp domain GSH-S_ATP PF02955.11 ESL11373.1 - 0.016 14.3 0.0 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Ribosomal_S11 PF00411.14 ESL11374.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S11 Flagellar_rod PF05149.7 ESL11375.1 - 1.1e-98 330.0 28.2 2.2e-98 329.0 19.6 1.5 1 0 0 1 1 1 1 Paraflagellar rod protein N6-adenineMlase PF10237.4 ESL11376.1 - 9.1e-37 126.2 0.0 1.7e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Methyltransf_26 PF13659.1 ESL11376.1 - 0.00076 19.4 0.2 0.002 18.1 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF4231 PF14015.1 ESL11376.1 - 0.066 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Methyltransf_18 PF12847.2 ESL11376.1 - 0.088 13.3 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESL11376.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain NDK PF00334.14 ESL11377.1 - 2.3e-21 75.9 0.0 1.8e-19 69.9 0.0 2.7 2 1 0 2 2 2 2 Nucleoside diphosphate kinase DnaJ PF00226.26 ESL11378.1 - 1.4e-21 75.9 0.3 2.5e-21 75.1 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESL11378.1 - 7.1e-08 31.9 0.1 1.9e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 X-domain of DnaJ-containing zf-MYND PF01753.13 ESL11379.1 - 0.00018 21.3 4.7 0.00018 21.3 3.3 3.3 3 0 0 3 3 3 1 MYND finger SET PF00856.23 ESL11379.1 - 0.074 13.3 0.2 0.2 11.9 0.2 1.7 1 0 0 1 1 1 0 SET domain DUF2225 PF09986.4 ESL11379.1 - 0.094 12.1 0.2 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Beta_helix PF13229.1 ESL11380.1 - 6.5e-08 32.4 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 ESL11380.1 - 5.2e-06 25.7 0.0 7.6e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) dsrm PF00035.20 ESL11382.1 - 2.1e-15 57.0 0.0 3.1e-08 34.0 0.0 5.6 5 0 0 5 5 5 2 Double-stranded RNA binding motif DND1_DSRM PF14709.1 ESL11382.1 - 0.013 15.7 0.0 0.032 14.4 0.0 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 SET PF00856.23 ESL11383.1 - 4.2e-08 33.6 3.3 2.9e-06 27.7 1.0 2.9 2 1 0 2 2 2 1 SET domain C1_1 PF00130.17 ESL11383.1 - 0.03 14.0 4.1 0.09 12.5 2.8 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) AAA PF00004.24 ESL11384.1 - 8.2e-10 38.9 0.0 1.4e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIB_HERC2 PF06701.8 ESL11385.1 - 0.026 14.4 0.9 0.06 13.3 0.3 1.9 2 0 0 2 2 2 0 Mib_herc2 IQ PF00612.22 ESL11386.1 - 0.91 9.3 18.0 0.13 11.9 2.8 3.0 3 0 0 3 3 3 0 IQ calmodulin-binding motif UFD1 PF03152.9 ESL11387.1 - 1.1e-45 154.8 0.0 1.3e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DKCLD PF08068.7 ESL11388.1 - 2.5e-27 94.5 0.5 5.8e-26 90.2 0.1 2.8 3 0 0 3 3 3 1 DKCLD (NUC011) domain TruB_N PF01509.13 ESL11388.1 - 1.3e-22 80.5 2.3 3.2e-19 69.5 1.6 3.1 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 ESL11388.1 - 4.8e-19 67.8 0.6 1.2e-18 66.5 0.4 1.7 1 0 0 1 1 1 1 PUA domain WW PF00397.21 ESL11389.1 - 0.046 13.6 0.1 0.046 13.6 0.1 2.0 2 0 0 2 2 2 0 WW domain PIH1 PF08190.7 ESL11390.1 - 1.4e-09 37.8 0.0 1.6e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 4F5 PF04419.9 ESL11392.1 - 1.9e-12 47.7 11.3 1.9e-12 47.7 7.8 2.0 1 1 1 2 2 2 1 4F5 protein family DUF874 PF05917.6 ESL11392.1 - 3.6 6.3 8.7 3.8 6.2 6.1 1.0 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) PTPlike_phytase PF14566.1 ESL11393.1 - 1.8e-104 346.1 0.1 3.8e-39 134.1 0.0 3.3 3 0 0 3 3 3 3 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 ESL11393.1 - 0.046 13.9 0.3 5.7 7.1 0.0 3.0 3 0 0 3 3 3 0 Tyrosine phosphatase family Sulfotransfer_3 PF13469.1 ESL11394.1 - 1 10.2 4.2 8 7.3 0.4 2.2 1 1 1 2 2 2 0 Sulfotransferase family HPS3_C PF14763.1 ESL11395.1 - 0.011 14.8 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, C-terminal FAD_binding_3 PF01494.14 ESL11396.1 - 2.5e-07 30.0 1.4 0.071 12.1 0.2 3.2 3 0 0 3 3 3 3 FAD binding domain 3HCDH_N PF02737.13 ESL11396.1 - 0.0046 16.6 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 ESL11396.1 - 0.007 15.3 3.6 0.019 13.8 2.5 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESL11396.1 - 0.022 15.1 0.0 0.082 13.3 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESL11396.1 - 0.033 14.1 0.3 0.096 12.7 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESL11396.1 - 0.046 12.8 0.1 0.11 11.5 0.1 1.5 1 0 0 1 1 1 0 Thi4 family zf-RING_2 PF13639.1 ESL11397.1 - 3.9e-11 42.6 3.7 1.8e-10 40.4 0.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 ESL11397.1 - 5.4e-11 42.4 1.0 8.4e-11 41.8 0.7 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESL11397.1 - 6.8e-06 25.6 2.4 3.4e-05 23.4 0.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL11397.1 - 8.4e-06 25.5 0.1 1.8e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 ESL11397.1 - 1.9e-05 24.1 1.3 4.7e-05 22.9 0.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL11397.1 - 4.7e-05 23.3 4.2 5.5e-05 23.1 0.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL11397.1 - 0.00039 20.0 0.3 0.00039 20.0 0.2 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESL11397.1 - 0.0061 16.2 2.5 0.0074 15.9 0.1 2.2 2 1 1 3 3 3 1 RING-type zinc-finger FANCL_C PF11793.3 ESL11397.1 - 0.01 15.7 4.7 0.33 10.9 3.3 2.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.1 ESL11397.1 - 0.01 15.3 0.1 0.023 14.2 0.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 ESL11397.1 - 0.085 12.7 2.3 0.095 12.5 0.4 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.6 ESL11397.1 - 0.18 11.8 1.2 0.42 10.6 0.8 1.6 1 0 0 1 1 1 0 RING-like domain UPF0547 PF10571.4 ESL11397.1 - 0.25 11.0 4.8 0.93 9.2 0.3 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 RINGv PF12906.2 ESL11397.1 - 0.26 11.3 4.7 1.3 9.1 1.5 2.3 2 0 0 2 2 2 0 RING-variant domain cwf21 PF08312.7 ESL11398.1 - 0.0036 17.1 0.2 0.014 15.2 0.1 2.0 1 0 0 1 1 1 1 cwf21 domain Pox_A_type_inc PF04508.7 ESL11398.1 - 0.33 10.8 5.1 13 5.8 0.0 4.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Spc7 PF08317.6 ESL11398.1 - 1.5 7.3 7.5 3.7 6.1 0.0 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein Striatin PF08232.7 ESL11398.1 - 1.6 9.0 14.0 2.7 8.3 0.1 3.2 3 0 0 3 3 3 0 Striatin family DUF3391 PF11871.3 ESL11398.1 - 2.9 8.1 7.9 0.19 11.9 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) IncA PF04156.9 ESL11398.1 - 3.3 7.2 14.7 3.4 7.2 0.1 3.3 3 0 0 3 3 3 0 IncA protein Col_cuticle_N PF01484.12 ESL11399.1 - 0.1 12.2 0.4 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain Pkinase PF00069.20 ESL11401.1 - 8.2e-67 225.0 0.0 1.1e-66 224.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11401.1 - 3.2e-43 147.6 0.0 4.5e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11401.1 - 8.3e-06 24.9 0.0 0.00087 18.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.17 ESL11401.1 - 0.00034 20.0 0.0 0.00058 19.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESL11401.1 - 0.0032 17.2 0.5 0.042 13.5 0.1 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family zf-Tim10_DDP PF02953.10 ESL11403.1 - 0.13 11.5 0.1 0.13 11.5 0.1 1.7 2 0 0 2 2 2 0 Tim10/DDP family zinc finger TPR_17 PF13431.1 ESL11404.1 - 6.8e-10 38.3 3.5 8.1e-05 22.5 0.3 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11404.1 - 1.8e-06 28.0 0.5 0.38 11.5 0.0 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESL11404.1 - 1.6e-05 24.4 1.0 0.0011 18.5 0.1 3.3 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.1 ESL11404.1 - 2.8e-05 24.3 4.2 0.00089 19.5 0.0 3.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11404.1 - 0.00013 21.6 0.7 0.0089 15.8 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL11404.1 - 0.00073 19.6 0.2 0.11 12.6 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ESL11404.1 - 0.0019 18.8 3.0 0.02 15.5 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL11404.1 - 0.011 16.0 0.2 0.21 12.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESL11404.1 - 0.018 15.1 0.7 0.045 13.8 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11404.1 - 0.067 12.8 0.3 2.4 7.8 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat HSP70 PF00012.15 ESL11405.1 - 9.4e-130 433.3 2.2 1e-129 433.1 1.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESL11405.1 - 1.1e-12 47.2 0.1 4.8e-11 41.8 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein SRI PF08236.6 ESL11405.1 - 0.018 14.9 0.2 0.059 13.3 0.1 1.7 1 1 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain StbA PF06406.6 ESL11405.1 - 0.019 13.8 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 StbA protein Asp_decarbox PF02261.11 ESL11405.1 - 0.019 14.5 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Aspartate decarboxylase FtsA PF14450.1 ESL11405.1 - 0.12 12.1 1.9 0.2 11.4 0.1 2.3 2 1 0 2 2 2 0 Cell division protein FtsA WD40 PF00400.27 ESL11407.1 - 1.2e-45 151.8 23.2 4.7e-10 38.9 0.5 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESL11407.1 - 0.013 13.6 2.2 0.11 10.6 0.1 2.6 1 1 1 3 3 3 0 Nucleoporin Nup120/160 3Beta_HSD PF01073.14 ESL11408.1 - 3.3e-09 35.8 0.0 4.6e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 ESL11408.1 - 3.8e-06 27.0 0.0 7e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 ESL11408.1 - 0.00042 20.6 0.0 0.00082 19.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.20 ESL11408.1 - 0.0029 17.5 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 ESL11408.1 - 0.0051 15.7 0.0 1.6 7.5 0.0 2.9 2 1 0 2 2 2 2 RmlD substrate binding domain NmrA PF05368.8 ESL11408.1 - 0.018 14.2 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family DapB_N PF01113.15 ESL11408.1 - 0.083 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Thioredoxin PF00085.15 ESL11409.1 - 0.0018 17.9 0.0 0.0032 17.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Egg_lysin PF01303.12 ESL11410.1 - 0.01 15.8 0.8 0.02 14.9 0.6 1.6 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) Reo_sigmaC PF04582.7 ESL11410.1 - 0.012 14.8 0.3 0.012 14.8 0.2 1.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein LRS4 PF10422.4 ESL11410.1 - 0.11 11.8 9.8 0.13 11.5 6.8 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF4364 PF14277.1 ESL11410.1 - 0.17 11.5 2.8 0.12 11.9 0.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4364) GAS PF13851.1 ESL11410.1 - 0.37 9.9 22.3 0.15 11.2 7.9 2.6 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1675 PF07897.6 ESL11410.1 - 2.1 8.1 9.5 2.5 7.8 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Phage_GP20 PF06810.6 ESL11410.1 - 2.3 7.6 11.0 1.2 8.6 0.4 2.4 1 1 0 2 2 2 0 Phage minor structural protein GP20 FUSC-like PF12805.2 ESL11410.1 - 3.1 6.6 9.6 1.6 7.6 5.3 1.4 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS RTBV_P46 PF06216.6 ESL11410.1 - 5.4 5.7 7.2 6.1 5.5 4.6 1.2 1 1 0 1 1 1 0 Rice tungro bacilliform virus P46 protein FlaC_arch PF05377.6 ESL11410.1 - 5.6 6.9 8.8 5.9 6.8 0.1 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Bacillus_HBL PF05791.6 ESL11410.1 - 7.7 5.8 9.4 1.1 8.5 0.6 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF3584 PF12128.3 ESL11411.1 - 0.0033 14.8 28.5 0.0039 14.6 19.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) ATP-synt_B PF00430.13 ESL11411.1 - 0.018 14.8 16.2 0.018 14.8 11.3 2.3 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) DinB_2 PF12867.2 ESL11411.1 - 0.18 12.1 5.1 0.19 12.0 1.1 2.3 1 1 0 2 2 2 0 DinB superfamily IncA PF04156.9 ESL11411.1 - 0.32 10.5 34.3 6.9 6.2 17.3 3.1 1 1 2 3 3 3 0 IncA protein WTX PF09422.5 ESL11411.1 - 1.5 7.7 7.0 1 8.2 3.9 1.4 1 1 0 1 1 1 0 WTX protein Birna_RdRp PF04197.7 ESL11411.1 - 4.3 5.2 16.8 4.9 5.0 11.7 1.0 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) Bacillus_HBL PF05791.6 ESL11411.1 - 7.1 5.9 11.6 0.44 9.8 1.9 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) FAD_binding_7 PF03441.9 ESL11412.1 - 3.3e-41 141.3 0.1 4.9e-41 140.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 ESL11412.1 - 1.4e-20 73.6 0.1 3.7e-20 72.3 0.1 1.7 1 0 0 1 1 1 1 DNA photolyase Synaptobrevin PF00957.16 ESL11413.1 - 1.1e-12 47.3 0.0 2.9e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 ESL11413.1 - 0.0035 16.8 0.0 0.017 14.6 0.0 2.0 2 0 0 2 2 2 1 Regulated-SNARE-like domain Reo_sigma1 PF01664.11 ESL11414.1 - 0.069 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Reovirus viral attachment protein sigma 1 Neuromodulin_N PF10580.4 ESL11414.1 - 0.56 9.9 0.1 0.56 9.9 0.0 2.1 2 0 0 2 2 2 0 Gap junction protein N-terminal region TYW3 PF02676.9 ESL11415.1 - 8.9e-33 113.1 0.0 1.1e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 NADH-G_4Fe-4S_3 PF10588.4 ESL11416.1 - 8.7e-17 60.0 0.3 8.7e-17 60.0 0.2 2.5 3 0 0 3 3 3 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.1 ESL11416.1 - 3.9e-12 45.8 0.1 1e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.22 ESL11416.1 - 2.1e-08 33.7 0.1 5.1e-08 32.5 0.1 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_18 PF13746.1 ESL11416.1 - 0.021 15.2 3.6 0.054 13.9 2.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_7 PF12838.2 ESL11416.1 - 0.089 13.1 6.0 0.11 12.8 1.9 2.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_2 PF12797.2 ESL11416.1 - 0.18 11.7 0.2 0.18 11.7 0.1 2.3 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_9 PF13187.1 ESL11416.1 - 1.3 9.2 6.1 0.68 10.2 2.2 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Methyltransf_11 PF08241.7 ESL11417.1 - 4.3e-20 72.0 0.0 1e-18 67.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11417.1 - 2e-14 53.4 0.0 3.2e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL11417.1 - 1.7e-11 44.0 0.1 2.6e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESL11417.1 - 1.1e-10 41.0 0.1 1.6e-10 40.5 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Sterol_MT_C PF08498.5 ESL11417.1 - 2.2e-09 37.1 0.0 6e-09 35.7 0.0 1.8 2 0 0 2 2 2 1 Sterol methyltransferase C-terminal Methyltransf_12 PF08242.7 ESL11417.1 - 1.2e-08 35.3 0.0 9.5e-08 32.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL11417.1 - 1.4e-08 34.9 0.1 3.3e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESL11417.1 - 1.1e-07 31.2 0.0 1.7e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESL11417.1 - 1.7e-07 31.7 0.0 7.8e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.5 ESL11417.1 - 0.0012 18.4 0.3 0.0018 17.8 0.2 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 ESL11417.1 - 0.0027 17.7 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL11417.1 - 0.0086 15.4 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_29 PF03141.11 ESL11417.1 - 0.048 12.0 0.0 0.067 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.1 ESL11417.1 - 0.051 13.2 0.2 0.093 12.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain PrmA PF06325.8 ESL11417.1 - 0.11 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Biotin_lipoyl PF00364.17 ESL11418.1 - 9.7e-13 47.5 0.0 1.8e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Acetyltransf_1 PF00583.19 ESL11419.1 - 5e-10 39.2 0.1 8.2e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL11419.1 - 2.2e-08 34.1 0.5 3.8e-08 33.3 0.4 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESL11419.1 - 3.5e-06 27.1 0.0 5e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.1 ESL11419.1 - 0.00025 21.5 0.1 0.01 16.3 0.1 2.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESL11419.1 - 0.008 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL11419.1 - 0.0089 15.8 0.2 0.025 14.4 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Glyco_transf_92 PF01697.22 ESL11419.1 - 0.082 12.1 0.2 0.16 11.2 0.0 1.5 2 0 0 2 2 2 0 Glycosyltransferase family 92 Peptidase_C1 PF00112.18 ESL11420.1 - 5.2e-67 225.9 4.2 7.6e-67 225.3 2.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.3 ESL11420.1 - 2.5e-23 81.8 8.4 2.5e-23 81.8 5.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.7 ESL11420.1 - 2.4e-10 40.5 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 ESL11420.1 - 0.00012 20.8 0.4 0.0024 16.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase C1-like family IQ PF00612.22 ESL11422.1 - 0.00067 19.0 1.8 0.0018 17.7 1.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif S1-P1_nuclease PF02265.11 ESL11423.1 - 1.8e-56 191.5 0.0 2.1e-56 191.3 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease AATF-Che1 PF13339.1 ESL11425.1 - 1.2 9.3 15.4 0.21 11.7 2.8 3.1 2 1 1 3 3 3 0 Apoptosis antagonizing transcription factor V_ATPase_I PF01496.14 ESL11425.1 - 3.8 5.2 4.7 5.6 4.6 3.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ApbA PF02558.11 ESL11426.1 - 0.045 13.1 0.0 0.2 11.1 0.0 2.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA SNARE PF05739.14 ESL11427.1 - 2.7e-05 23.7 2.7 2.7e-05 23.7 1.8 2.6 2 0 0 2 2 2 1 SNARE domain WXG100 PF06013.7 ESL11427.1 - 0.027 14.4 6.2 1.3 9.0 0.2 3.4 2 1 0 2 2 2 0 Proteins of 100 residues with WXG MRFAP1 PF15155.1 ESL11427.1 - 0.063 13.6 4.5 0.098 12.9 2.6 1.7 1 1 0 1 1 1 0 MORF4 family-associated protein1 Baculo_PEP_C PF04513.7 ESL11427.1 - 0.075 12.8 1.9 0.16 11.7 0.1 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mago_nashi PF02792.9 ESL11427.1 - 0.1 12.2 0.3 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 Mago nashi protein Syntaxin PF00804.20 ESL11427.1 - 0.54 10.4 14.9 1.3 9.2 4.4 2.8 3 0 0 3 3 3 0 Syntaxin DnaJ PF00226.26 ESL11429.1 - 1.5e-22 79.1 0.6 4e-22 77.7 0.4 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.3 ESL11429.1 - 3.1e-07 30.3 6.8 7.2e-07 29.1 4.7 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESL11429.1 - 2.8e-05 24.1 3.4 5.3e-05 23.2 2.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESL11429.1 - 0.00055 20.0 1.2 0.0027 17.7 0.3 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 ESL11429.1 - 0.011 16.0 1.6 0.031 14.6 1.1 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type ARGLU PF15346.1 ESL11429.1 - 0.4 10.4 28.3 0.9 9.2 19.6 1.6 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 zf-RING_4 PF14570.1 ESL11429.1 - 2.4 7.7 5.0 0.72 9.4 0.3 2.4 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain EF-hand_7 PF13499.1 ESL11430.1 - 0.21 11.7 0.0 0.41 10.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair Ank_2 PF12796.2 ESL11431.1 - 7.9e-56 186.3 3.3 4.8e-16 58.8 0.0 4.0 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.25 ESL11431.1 - 1.5e-28 97.1 5.9 7e-06 25.6 0.1 6.9 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.1 ESL11431.1 - 1.5e-25 89.0 5.0 3.5e-09 36.9 0.1 4.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESL11431.1 - 8.2e-23 79.9 16.6 1.1e-07 31.8 0.2 5.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL11431.1 - 5e-19 66.5 2.4 0.0046 17.0 0.2 6.3 5 0 0 5 5 5 5 Ankyrin repeat zf-DHHC PF01529.15 ESL11431.1 - 4.5e-05 22.9 2.0 4.5e-05 22.9 1.4 2.2 2 1 0 2 2 2 1 DHHC palmitoyltransferase Galactosyl_T PF01762.16 ESL11432.1 - 5.3e-10 39.2 0.0 0.00022 20.8 0.0 3.1 2 1 0 2 2 2 2 Galactosyltransferase TTL PF03133.10 ESL11433.1 - 2.2e-84 282.8 0.0 3.2e-84 282.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESL11433.1 - 0.00087 19.0 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 ESL11433.1 - 0.04 12.7 0.0 0.73 8.5 0.0 2.2 2 0 0 2 2 2 0 YheC/D like ATP-grasp ATP-grasp_3 PF02655.9 ESL11433.1 - 0.053 13.3 0.0 6.4 6.6 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.6 ESL11433.1 - 0.18 11.2 0.0 2.2 7.7 0.0 2.1 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Clathrin PF00637.15 ESL11436.1 - 0.00012 21.6 1.5 0.0092 15.5 0.0 3.6 1 1 3 4 4 4 1 Region in Clathrin and VPS TPR_14 PF13428.1 ESL11436.1 - 0.022 15.3 2.4 17 6.3 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat NSF PF02071.15 ESL11436.1 - 0.033 14.6 5.1 3.2 8.7 0.3 5.0 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_11 PF13414.1 ESL11436.1 - 0.05 13.2 5.0 2.1 8.0 0.1 4.1 4 1 0 4 4 4 0 TPR repeat TPR_2 PF07719.12 ESL11436.1 - 0.12 12.4 2.2 13 6.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Methyltransf_18 PF12847.2 ESL11437.1 - 9.7e-18 64.7 0.0 2.7e-17 63.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11437.1 - 1.7e-13 50.4 0.0 5.4e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.1 ESL11437.1 - 5.2e-13 49.0 0.0 8.1e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL11437.1 - 1.5e-11 44.6 0.0 2.7e-05 24.5 0.0 2.6 2 1 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.7 ESL11437.1 - 6.7e-11 42.5 0.0 3.9e-10 40.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL11437.1 - 3.6e-05 24.0 0.0 0.00016 21.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL11437.1 - 0.00012 22.0 0.0 0.00029 20.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESL11437.1 - 0.0028 17.0 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 1 Nodulation protein S (NodS) Methyltransf_4 PF02390.12 ESL11437.1 - 0.066 12.2 0.0 0.33 9.9 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase PCMT PF01135.14 ESL11437.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AAA PF00004.24 ESL11439.1 - 6.2e-50 168.8 0.0 3.1e-36 124.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL11439.1 - 8.7e-11 42.6 0.5 0.00094 19.9 0.2 3.0 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ESL11439.1 - 5.8e-08 32.9 1.6 0.017 15.2 0.6 4.2 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESL11439.1 - 2.3e-07 30.5 0.0 0.00018 21.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESL11439.1 - 7.5e-07 28.8 0.0 0.0021 17.7 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_16 PF13191.1 ESL11439.1 - 1.4e-06 28.4 0.1 0.011 15.7 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.1 ESL11439.1 - 2.9e-06 27.6 0.0 0.033 14.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 ESL11439.1 - 3.8e-06 25.8 0.0 0.024 13.3 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 ESL11439.1 - 1.9e-05 24.5 0.0 0.02 14.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESL11439.1 - 2.5e-05 24.1 0.0 0.52 10.1 0.0 3.1 2 1 1 3 3 3 2 AAA domain KTI12 PF08433.5 ESL11439.1 - 7.1e-05 22.1 0.0 0.024 13.8 0.0 2.5 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Mg_chelatase PF01078.16 ESL11439.1 - 0.0003 20.0 0.1 0.0044 16.2 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 ESL11439.1 - 0.002 18.2 0.0 0.26 11.4 0.0 2.5 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.12 ESL11439.1 - 0.0026 17.2 0.1 0.076 12.4 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_28 PF13521.1 ESL11439.1 - 0.0035 17.3 0.0 3.3 7.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 ESL11439.1 - 0.0044 16.9 0.0 0.05 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) NACHT PF05729.7 ESL11439.1 - 0.0049 16.5 0.1 1.8 8.1 0.0 3.5 2 2 0 2 2 2 1 NACHT domain RuvB_N PF05496.7 ESL11439.1 - 0.0063 15.5 0.0 0.06 12.3 0.0 2.3 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.6 ESL11439.1 - 0.0074 15.8 0.0 0.34 10.5 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 ESL11439.1 - 0.011 15.6 0.0 0.035 14.0 0.0 1.9 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain Zeta_toxin PF06414.7 ESL11439.1 - 0.021 13.9 0.1 3.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.21 ESL11439.1 - 0.024 14.0 0.0 0.8 9.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 ESL11439.1 - 0.028 14.0 0.1 9.6 5.8 0.0 2.9 2 2 0 2 2 2 0 Archaeal ATPase AAA_25 PF13481.1 ESL11439.1 - 0.034 13.5 4.2 4.7 6.5 0.1 3.5 3 1 1 4 4 4 0 AAA domain DUF2075 PF09848.4 ESL11439.1 - 0.036 13.0 0.1 3.5 6.5 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.1 ESL11439.1 - 0.047 13.2 0.1 0.18 11.3 0.1 2.0 2 0 0 2 2 1 0 AAA domain KaiC PF06745.8 ESL11439.1 - 0.074 12.1 0.0 0.52 9.3 0.0 2.2 2 0 0 2 2 2 0 KaiC 6PF2K PF01591.13 ESL11439.1 - 0.11 11.5 0.0 14 4.6 0.0 2.6 2 1 0 2 2 2 0 6-phosphofructo-2-kinase DEAD PF00270.24 ESL11439.1 - 0.12 11.8 0.3 5.4 6.4 0.0 2.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase ABC_tran PF00005.22 ESL11439.1 - 0.13 12.5 0.0 12 6.2 0.0 2.6 2 1 0 2 2 2 0 ABC transporter CPT PF07931.7 ESL11439.1 - 0.13 11.8 0.0 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Parvo_NS1 PF01057.12 ESL11439.1 - 0.24 10.2 0.0 0.48 9.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Reo_sigmaC PF04582.7 ESL11440.1 - 0.003 16.7 10.3 0.0037 16.4 6.7 1.4 1 1 0 1 1 1 1 Reovirus sigma C capsid protein CCDC155 PF14662.1 ESL11440.1 - 2.8 7.5 45.6 0.71 9.4 25.7 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 GldM_N PF12081.3 ESL11440.1 - 3.5 7.0 13.4 5.9 6.3 7.4 2.1 1 1 1 2 2 2 0 GldM N-terminal domain GAS PF13851.1 ESL11440.1 - 7.7 5.6 37.4 14 4.8 11.5 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 ESL11440.1 - 8.8 6.1 45.5 13 5.6 12.7 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.1 ESL11440.1 - 9.7 6.1 46.0 0.26 11.2 14.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) AAA_13 PF13166.1 ESL11440.1 - 9.9 4.4 26.4 3.9 5.8 11.5 2.0 1 1 1 2 2 2 0 AAA domain AATF-Che1 PF13339.1 ESL11443.1 - 0.017 15.2 3.2 1.3 9.1 0.2 3.5 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor His_Phos_1 PF00300.17 ESL11443.1 - 0.059 13.4 3.3 1.7 8.7 1.2 2.8 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) GST_N_3 PF13417.1 ESL11444.1 - 1.1e-08 35.1 0.0 2.1e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESL11444.1 - 2.4e-08 34.0 0.0 4.2e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESL11444.1 - 9.4e-07 28.7 0.0 2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESL11444.1 - 0.00048 20.0 0.0 0.00098 19.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESL11444.1 - 0.0042 17.5 0.0 0.024 15.1 0.0 2.2 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESL11444.1 - 0.008 16.0 0.2 0.022 14.6 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain XRN_N PF03159.13 ESL11445.1 - 2.7e-18 66.2 0.0 8.4e-18 64.6 0.0 1.7 1 1 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XPG_N PF00752.12 ESL11445.1 - 0.1 12.8 0.0 0.63 10.3 0.0 2.4 3 1 0 3 3 3 0 XPG N-terminal domain LBP_BPI_CETP PF01273.20 ESL11446.1 - 0.046 13.0 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain PPR_2 PF13041.1 ESL11447.1 - 1.7e-11 43.8 0.0 0.0036 17.2 0.0 4.3 4 0 0 4 4 4 3 PPR repeat family PPR PF01535.15 ESL11447.1 - 9.1e-07 28.4 1.5 0.24 11.4 0.0 4.0 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.1 ESL11447.1 - 7.3e-05 22.7 0.3 2.3 8.7 0.0 4.3 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESL11447.1 - 0.0017 17.7 3.2 0.24 10.9 0.0 3.7 3 0 0 3 3 3 1 PPR repeat Vps16_N PF04841.8 ESL11448.1 - 8.1e-39 133.3 0.0 8.3e-33 113.5 0.0 2.2 2 0 0 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.7 ESL11448.1 - 6.9e-28 97.5 0.4 4.3e-16 58.7 0.0 2.4 2 0 0 2 2 2 2 Vps16, C-terminal region LRR_4 PF12799.2 ESL11449.1 - 6.7e-24 83.0 21.4 0.00092 18.7 0.0 7.4 5 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL11449.1 - 1.5e-18 66.3 31.1 0.00014 21.5 1.2 5.9 4 2 2 6 6 6 5 Leucine rich repeat LRR_1 PF00560.28 ESL11449.1 - 2.4e-09 35.9 28.3 3.6 8.0 0.8 11.7 9 3 2 11 11 11 3 Leucine Rich Repeat LRR_7 PF13504.1 ESL11449.1 - 2.4e-05 23.8 25.3 14 6.4 0.0 11.7 11 0 0 11 11 11 1 Leucine rich repeat DUF1399 PF07173.7 ESL11449.1 - 0.0043 17.3 2.5 0.097 12.9 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1399) LRR_6 PF13516.1 ESL11449.1 - 0.05 13.6 24.7 29 5.1 0.1 10.1 9 1 1 10 10 10 0 Leucine Rich repeat Baculo_PP31 PF05311.6 ESL11449.1 - 0.1 11.8 0.6 0.27 10.4 0.1 1.9 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) DUF1126 PF06565.7 ESL11450.1 - 2.3e-40 135.7 0.3 4.9e-13 48.3 0.0 3.6 3 0 0 3 3 3 3 Repeat of unknown function (DUF1126) EF-hand_7 PF13499.1 ESL11450.1 - 5.4e-08 32.8 0.1 3.2e-07 30.3 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL11450.1 - 7.4e-07 28.6 0.2 0.00022 20.7 0.0 3.4 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 ESL11450.1 - 0.018 14.3 0.4 0.96 8.9 0.0 3.7 4 0 0 4 4 4 0 EF hand DUF1456 PF07308.8 ESL11450.1 - 0.04 13.9 0.1 0.85 9.7 0.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1456) GTP_EFTU_D3 PF03143.12 ESL11451.1 - 2e-36 124.1 0.1 1.4e-35 121.3 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESL11451.1 - 4e-18 65.3 0.6 4e-18 65.3 0.4 1.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.22 ESL11451.1 - 4.6e-07 29.4 0.0 9.6e-07 28.4 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.1 ESL11451.1 - 6.9e-06 25.6 0.3 2.2e-05 23.9 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.13 ESL11451.1 - 0.0077 16.1 0.2 0.15 11.8 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, dimerisation domain Sod_Fe_C PF02777.13 ESL11452.1 - 1.2e-28 99.0 0.4 2.8e-28 97.8 0.2 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 ESL11452.1 - 6.3e-18 64.8 0.2 1.6e-17 63.4 0.1 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Peptidase_S9 PF00326.16 ESL11455.1 - 2.9e-35 121.4 0.0 6.8e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.10 ESL11455.1 - 2.8e-21 75.6 0.0 5e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain ATP11 PF06644.6 ESL11456.1 - 2.2e-22 79.8 0.2 2.8e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 ATP11 protein Spt4 PF06093.8 ESL11458.1 - 6.2e-13 48.4 0.1 1.1e-12 47.6 0.0 1.5 1 1 0 1 1 1 1 Spt4/RpoE2 zinc finger CobT PF06213.7 ESL11458.1 - 0.0053 15.9 2.2 0.0065 15.6 1.5 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Nucleoplasmin PF03066.10 ESL11458.1 - 0.028 13.9 2.7 0.039 13.4 1.8 1.2 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 ESL11458.1 - 0.12 11.9 1.3 0.14 11.7 0.9 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2072 PF09845.4 ESL11458.1 - 0.13 12.1 0.6 0.82 9.6 0.1 1.9 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) NOA36 PF06524.7 ESL11458.1 - 7.4 5.7 6.8 11 5.1 4.7 1.2 1 0 0 1 1 1 0 NOA36 protein PPR_3 PF13812.1 ESL11459.1 - 0.013 15.7 0.8 6.3 7.3 0.0 3.3 3 0 0 3 3 3 0 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESL11459.1 - 0.014 15.3 0.1 0.058 13.3 0.0 1.9 2 0 0 2 2 2 0 PPR repeat family FKBP_C PF00254.23 ESL11460.1 - 6.2e-26 90.2 0.0 7e-26 90.0 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CelD_N PF02927.9 ESL11460.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 N-terminal ig-like domain of cellulase Adaptin_N PF01602.15 ESL11461.1 - 3.6e-107 358.8 0.3 4.9e-107 358.4 0.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 ESL11461.1 - 2e-20 73.4 0.0 5.8e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ESL11461.1 - 4.7e-11 42.8 0.4 3.6e-06 27.1 0.0 4.4 2 2 1 3 3 3 2 HEAT repeats B2-adapt-app_C PF09066.5 ESL11461.1 - 0.00012 21.8 0.0 0.00033 20.5 0.0 1.8 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.17 ESL11461.1 - 0.00012 21.8 6.1 0.048 13.7 0.0 5.4 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.1 ESL11461.1 - 0.049 14.1 0.2 0.89 10.1 0.0 3.3 2 1 0 2 2 2 0 HEAT-like repeat Sin_N PF04801.8 ESL11462.1 - 2.5e-68 230.8 0.0 3.1e-68 230.5 0.0 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region LRR_9 PF14580.1 ESL11463.1 - 8.6e-22 77.5 0.5 5.8e-12 45.5 0.1 2.1 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 ESL11463.1 - 0.0005 19.7 1.7 21 5.6 0.0 4.4 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_4 PF12799.2 ESL11463.1 - 0.0033 17.0 2.7 0.22 11.2 0.2 3.2 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL11463.1 - 0.0065 16.2 3.8 16 5.3 0.1 3.1 2 1 0 2 2 2 1 Leucine rich repeat zf-Tim10_DDP PF02953.10 ESL11464.1 - 5e-12 44.9 1.9 7.2e-12 44.4 1.3 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 ESL11464.1 - 0.019 14.4 1.3 0.023 14.1 0.9 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) U-box PF04564.10 ESL11466.1 - 0.012 15.5 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 U-box domain ALO PF04030.9 ESL11468.1 - 1.7e-74 250.7 3.3 3.5e-72 243.0 1.1 2.1 1 1 1 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 ESL11468.1 - 1e-20 73.6 0.1 2.1e-20 72.6 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain DEAD PF00270.24 ESL11469.1 - 9.1e-09 35.0 0.0 2.2e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL11469.1 - 8.9e-07 28.6 0.1 2e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 ESL11469.1 - 7.2e-05 22.7 0.0 0.00027 20.8 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) GTP_EFTU PF00009.22 ESL11470.1 - 2.3e-34 118.4 1.7 2.4e-34 118.3 0.0 1.9 2 0 0 2 2 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 ESL11470.1 - 4.9e-15 55.3 0.1 1.6e-14 53.6 0.0 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 ESL11470.1 - 3e-13 49.6 0.1 6.8e-08 32.5 0.0 3.9 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESL11470.1 - 2.3e-06 27.5 0.0 6.3e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 ESL11470.1 - 3.1e-05 23.5 0.0 9.7e-05 21.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 ATP_bind_1 PF03029.12 ESL11470.1 - 0.00056 19.5 0.2 0.0021 17.6 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Miro PF08477.8 ESL11470.1 - 0.0008 19.8 0.0 0.0051 17.2 0.0 2.5 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 ESL11470.1 - 0.0032 17.6 0.0 0.024 14.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESL11470.1 - 0.011 15.7 0.1 0.011 15.7 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain Ras PF00071.17 ESL11470.1 - 0.014 14.7 0.0 0.11 11.9 0.0 2.4 2 1 0 2 2 2 0 Ras family Dynamin_N PF00350.18 ESL11470.1 - 0.072 12.9 12.9 1.6 8.5 0.0 4.8 2 1 1 4 4 4 0 Dynamin family DUF258 PF03193.11 ESL11470.1 - 0.1 11.8 0.0 0.48 9.5 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function, DUF258 V_ATPase_I PF01496.14 ESL11470.1 - 3.5 5.3 5.4 6.8 4.4 3.8 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Proteasome PF00227.21 ESL11472.1 - 2e-37 128.3 0.1 2.7e-37 127.9 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESL11472.1 - 7.2e-12 44.4 0.2 1.3e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DegQ PF08181.6 ESL11472.1 - 0.097 12.4 0.1 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 DegQ (SacQ) family V-ATPase_H_N PF03224.9 ESL11474.1 - 1.1e-67 228.3 0.0 1.6e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 ESL11474.1 - 1.4e-43 147.5 0.0 2.9e-42 143.3 0.0 2.4 2 0 0 2 2 2 1 V-ATPase subunit H PSP1 PF04468.7 ESL11475.1 - 2e-16 59.7 1.7 3.1e-16 59.1 1.2 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region IFT43 PF15305.1 ESL11476.1 - 0.069 13.1 2.4 0.082 12.9 1.6 1.2 1 0 0 1 1 1 0 Intraflagellar transport protein 43 Ada3 PF10198.4 ESL11476.1 - 0.4 10.4 4.6 0.51 10.0 3.1 1.4 1 1 0 1 1 1 0 Histone acetyltransferases subunit 3 DAP PF15228.1 ESL11476.1 - 0.45 11.2 5.0 0.57 10.9 0.0 2.5 2 1 0 2 2 2 0 Death-associated protein KH_1 PF00013.24 ESL11477.1 - 8.1e-06 25.3 0.2 2.5e-05 23.8 0.1 1.8 1 0 0 1 1 1 1 KH domain Pkinase PF00069.20 ESL11478.1 - 1.9e-50 171.4 0.1 1.4e-45 155.5 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11478.1 - 4.5e-26 91.4 0.0 1.8e-22 79.6 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESL11478.1 - 3.5e-07 29.4 0.0 5.6e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like GDC-P PF02347.11 ESL11479.1 - 7.1e-174 578.4 0.0 7.6e-163 542.1 0.0 3.0 3 0 0 3 3 3 3 Glycine cleavage system P-protein MetW PF07021.7 ESL11479.1 - 0.057 12.7 0.0 4.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Metallophos PF00149.23 ESL11480.1 - 3.4e-38 131.0 0.1 4.2e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pkinase PF00069.20 ESL11481.1 - 3.2e-54 183.8 0.0 4.6e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11481.1 - 8.7e-35 120.0 0.0 1.7e-34 119.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11481.1 - 1.5e-06 27.4 0.0 1.5e-05 24.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like PH PF00169.24 ESL11481.1 - 6e-06 26.4 0.0 6.4e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 PH domain PH_9 PF15410.1 ESL11481.1 - 0.011 15.8 0.0 0.048 13.8 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain Rhodanese PF00581.15 ESL11482.1 - 0.0025 18.1 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain DUF3325 PF11804.3 ESL11483.1 - 0.0048 16.8 0.1 0.0075 16.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3325) ProSAAS PF07259.7 ESL11483.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 ProSAAS precursor TLD PF07534.11 ESL11484.1 - 4.6e-23 81.7 0.1 1.4e-12 47.7 0.0 2.1 2 0 0 2 2 2 2 TLD Helicase_C PF00271.26 ESL11487.1 - 4.6e-26 90.4 0.5 9.5e-26 89.4 0.3 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 ESL11487.1 - 0.0051 16.7 0.0 0.0083 16.1 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain GatB_Yqey PF02637.13 ESL11487.1 - 0.11 12.1 0.1 0.33 10.6 0.0 1.7 2 0 0 2 2 2 0 GatB domain VKOR PF07884.9 ESL11488.1 - 1.4e-13 50.8 17.4 6.7e-13 48.6 12.1 1.8 1 1 0 1 1 1 1 Vitamin K epoxide reductase family DUF1494 PF07379.6 ESL11488.1 - 0.1 12.4 1.8 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1494) cNMP_binding PF00027.24 ESL11489.1 - 8.8e-08 31.8 0.0 0.046 13.5 0.0 3.8 3 1 0 3 3 3 3 Cyclic nucleotide-binding domain DUF667 PF05018.8 ESL11491.1 - 7.5e-06 25.3 0.0 1.2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF667) IQ PF00612.22 ESL11492.1 - 2.5e-09 35.9 23.2 1.7e-05 23.9 1.3 5.3 4 0 0 4 4 4 4 IQ calmodulin-binding motif Pkinase PF00069.20 ESL11493.1 - 1.5e-07 30.8 0.0 3.6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Beta_helix PF13229.1 ESL11495.1 - 4e-92 306.1 66.1 8.2e-12 45.1 10.6 13.8 1 1 14 15 15 15 15 Right handed beta helix region NosD PF05048.8 ESL11495.1 - 6.8e-62 208.7 32.5 1.7e-07 30.6 0.7 13.1 3 2 5 12 12 12 12 Periplasmic copper-binding protein (NosD) CDC73 PF05179.9 ESL11496.1 - 8.7e-17 61.3 1.0 9.6e-17 61.2 0.7 1.0 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family E1-E2_ATPase PF00122.15 ESL11497.1 - 4.2e-50 169.9 0.4 8.8e-50 168.8 0.3 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESL11497.1 - 9.4e-35 119.7 6.2 9.4e-35 119.7 4.3 2.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESL11497.1 - 3e-16 60.4 0.0 4.4e-15 56.6 0.0 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESL11497.1 - 1.4e-11 44.9 0.0 4.2e-11 43.3 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESL11497.1 - 2.7e-06 27.1 0.2 6.2e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESL11497.1 - 0.00017 21.4 0.0 0.00041 20.2 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 ESL11497.1 - 0.0057 16.0 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus YokU PF14122.1 ESL11497.1 - 0.17 11.6 0.0 5.5 6.7 0.0 2.4 2 0 0 2 2 2 0 YokU-like protein Robl_LC7 PF03259.12 ESL11498.1 - 1.4e-07 30.9 0.0 1.7e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain DnaJ PF00226.26 ESL11499.1 - 2.8e-09 36.5 0.0 4.7e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain F1F0-ATPsyn_F PF10791.4 ESL11499.1 - 0.0011 19.0 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi Paf67 PF10255.4 ESL11500.1 - 0.013 14.3 0.1 0.023 13.6 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 ESL11500.1 - 0.038 13.9 0.6 0.18 11.7 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11500.1 - 0.051 13.2 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Kinesin PF00225.18 ESL11502.1 - 4.1e-78 262.4 0.0 7.1e-45 153.1 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain WD40_alt PF14077.1 ESL11502.1 - 3.3 7.4 4.5 1.7 8.3 1.0 2.0 2 0 0 2 2 2 0 Alternative WD40 repeat motif IQ PF00612.22 ESL11503.1 - 0.0055 16.2 0.0 0.014 14.9 0.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif TPR_12 PF13424.1 ESL11503.1 - 0.11 12.3 0.1 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat WD40 PF00400.27 ESL11504.1 - 7.6e-13 47.8 8.4 1.9e-08 33.8 0.0 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat Proteasom_Rpn13 PF04683.8 ESL11505.1 - 2.1e-14 53.3 0.0 3.4e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Ribosomal_S30AE PF02482.14 ESL11506.1 - 0.064 13.6 0.1 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein Ribosomal_S19 PF00203.16 ESL11508.1 - 5.3e-28 96.4 0.3 9.4e-28 95.6 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S19 PmbA_TldD PF01523.11 ESL11508.1 - 0.023 13.9 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase PGK PF00162.14 ESL11509.1 - 5.2e-149 495.9 0.0 1.2e-148 494.7 0.0 1.5 1 1 0 1 1 1 1 Phosphoglycerate kinase Coatomer_E PF04733.9 ESL11511.1 - 6.6e-33 114.1 1.8 2.6e-32 112.1 1.2 1.8 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_16 PF13432.1 ESL11511.1 - 1.1e-06 29.1 16.8 0.00058 20.4 0.2 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11511.1 - 4.8e-06 26.8 12.1 0.021 15.1 0.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL11511.1 - 3.6e-05 23.6 13.9 0.0032 17.3 1.6 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESL11511.1 - 0.00014 21.4 9.7 0.0012 18.4 0.1 4.0 3 1 1 4 4 4 2 TPR repeat TPR_14 PF13428.1 ESL11511.1 - 0.0022 18.4 21.9 0.075 13.7 0.4 6.0 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11511.1 - 0.019 14.5 0.6 7.9 6.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MutS_III PF05192.13 ESL11511.1 - 0.024 14.4 0.3 0.047 13.4 0.2 1.5 1 0 0 1 1 1 0 MutS domain III TPR_7 PF13176.1 ESL11511.1 - 0.031 14.0 2.6 3.1 7.8 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11511.1 - 0.97 9.5 14.0 0.25 11.3 0.2 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESL11511.1 - 1.6 9.3 17.1 3 8.5 1.6 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Pyr_redox_2 PF07992.9 ESL11514.1 - 1.5e-06 28.2 0.0 3.7e-06 26.9 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESL11514.1 - 0.0016 18.2 0.5 0.12 12.1 0.1 2.9 2 1 1 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESL11514.1 - 0.002 18.1 0.0 0.98 9.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESL11514.1 - 0.0041 17.5 0.3 0.16 12.4 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF3784 PF12650.2 ESL11515.1 - 0.076 12.9 1.7 0.48 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Cation_efflux PF01545.16 ESL11517.1 - 4.3e-52 176.9 10.5 4.3e-52 176.9 7.3 2.5 2 1 1 3 3 3 1 Cation efflux family CTP_transf_1 PF01148.15 ESL11518.1 - 3e-60 204.0 26.9 4.3e-60 203.5 18.6 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Fig1 PF12351.3 ESL11518.1 - 0.023 14.5 0.8 0.023 14.5 0.5 2.5 3 1 0 3 3 3 0 Ca2+ regulator and membrane fusion protein Fig1 HemY_N PF07219.8 ESL11518.1 - 0.95 9.0 7.2 0.2 11.1 2.4 1.8 2 0 0 2 2 2 0 HemY protein N-terminus Erythrovirus_X PF06795.6 ESL11518.1 - 1.6 8.8 6.8 0.97 9.4 0.1 2.9 2 1 0 3 3 3 0 Erythrovirus X protein IMS PF00817.15 ESL11519.1 - 2.3e-43 147.5 0.0 3.4e-43 146.9 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 ESL11519.1 - 3.6e-07 30.1 0.0 7e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 ESL11519.1 - 0.0083 16.1 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif HSP90 PF00183.13 ESL11520.1 - 4.2e-262 870.2 32.5 5e-262 870.0 22.5 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 ESL11520.1 - 7.9e-12 44.8 0.0 1.5e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESL11520.1 - 9.2e-12 44.7 0.0 9.2e-12 44.7 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.4 ESL11520.1 - 0.029 14.1 0.4 0.087 12.6 0.3 1.8 1 0 0 1 1 1 0 Tumour suppressor protein DUF1510 PF07423.6 ESL11520.1 - 0.37 10.1 22.0 0.01 15.2 8.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) FIBP PF05427.6 ESL11521.1 - 2.1e-05 23.9 0.2 0.00011 21.5 0.2 2.0 1 1 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) Aa_trans PF01490.13 ESL11522.1 - 1.5e-21 76.3 15.7 1.8e-21 76.1 10.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL11522.1 - 4.3e-07 29.0 15.1 5.4e-07 28.7 10.5 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESL11522.1 - 0.011 14.2 16.9 0.013 14.0 11.7 1.0 1 0 0 1 1 1 0 Amino acid permease Skp1_POZ PF03931.10 ESL11524.1 - 0.019 15.0 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Ribosomal_L1 PF00687.16 ESL11525.1 - 8.4e-33 113.5 2.3 9.2e-33 113.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Antimicrobial_4 PF08024.6 ESL11525.1 - 1.2 9.0 3.6 2.2 8.2 0.4 2.4 2 0 0 2 2 2 0 Ant antimicrobial peptide VHS PF00790.14 ESL11526.1 - 1.8e-08 34.1 0.4 4.1e-08 32.9 0.1 1.7 2 0 0 2 2 2 1 VHS domain Maf PF02545.9 ESL11527.1 - 2.1e-41 141.2 0.0 3e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 Maf-like protein Peptidase_M8 PF01457.11 ESL11528.1 - 7.5e-130 433.7 0.0 9.8e-130 433.3 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin SprT-like PF10263.4 ESL11528.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 SprT-like family LNS2 PF08235.8 ESL11529.1 - 4.8e-56 188.6 0.0 7.2e-56 188.1 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 ESL11529.1 - 3.6e-21 74.8 0.0 8.7e-21 73.6 0.0 1.6 1 0 0 1 1 1 1 lipin, N-terminal conserved region Sec3_C PF09763.4 ESL11529.1 - 0.15 10.1 0.2 0.23 9.5 0.1 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 EBP PF05241.7 ESL11530.1 - 4.1e-44 149.9 3.5 7.1e-44 149.1 2.4 1.3 1 0 0 1 1 1 1 Emopamil binding protein Adaptin_binding PF10199.4 ESL11532.1 - 1.8e-09 38.0 3.6 0.0032 17.7 1.8 3.9 3 1 0 3 3 3 3 Alpha and gamma adaptin binding protein p34 Pkinase PF00069.20 ESL11535.1 - 1.7e-64 217.4 0.0 2.1e-64 217.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11535.1 - 6.1e-31 107.4 0.0 7.5e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11535.1 - 2.5e-12 46.3 0.0 4.8e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESL11535.1 - 2.6e-05 23.3 0.1 4.3e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Proteasome PF00227.21 ESL11536.1 - 4.2e-30 104.4 0.0 5.1e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESL11536.1 - 7.5e-14 50.7 0.3 1.4e-13 49.8 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature NAD_binding_2 PF03446.10 ESL11537.1 - 0.26 11.1 3.5 0.55 10.0 0.4 2.3 1 1 1 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase CLASP_N PF12348.3 ESL11538.1 - 0.012 14.9 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 CLASP N terminal DUF1108 PF06531.6 ESL11538.1 - 0.14 12.3 0.1 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1108) Avl9 PF09794.4 ESL11540.1 - 0.0025 16.3 0.0 0.0041 15.6 0.0 1.3 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 ESL11540.1 - 0.0044 16.7 0.0 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 Stabilization of polarity axis DENN PF02141.16 ESL11540.1 - 0.0097 15.6 7.0 0.38 10.4 0.3 3.2 2 1 0 3 3 3 2 DENN (AEX-3) domain zf-C3HC4_3 PF13920.1 ESL11541.1 - 1.8e-11 43.5 11.3 1.8e-11 43.5 7.8 4.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Ninjurin PF04923.7 ESL11541.1 - 0.062 13.0 2.0 0.067 12.9 0.0 1.9 2 0 0 2 2 2 0 Ninjurin SieB PF14163.1 ESL11541.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Superinfection exclusion protein B BCLP PF12304.3 ESL11541.1 - 0.78 9.1 7.3 0.88 8.9 2.3 2.2 2 0 0 2 2 2 0 Beta-casein like protein PseudoU_synth_2 PF00849.17 ESL11542.1 - 3.2e-18 66.1 0.0 2.2e-17 63.4 0.0 2.3 1 1 0 1 1 1 1 RNA pseudouridylate synthase DEAD PF00270.24 ESL11543.1 - 1.4e-43 148.3 0.0 8.5e-42 142.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL11543.1 - 2.2e-22 78.6 0.2 2.1e-21 75.5 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL11543.1 - 0.0024 17.7 0.0 0.056 13.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 ESL11543.1 - 0.042 13.8 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain Metalloenzyme PF01676.13 ESL11543.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily DUF4200 PF13863.1 ESL11544.1 - 0.001 19.0 6.5 0.001 19.0 4.5 2.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4200) DUF641 PF04859.7 ESL11544.1 - 0.0014 18.3 2.8 0.0014 18.3 1.9 2.1 2 1 1 3 3 3 1 Plant protein of unknown function (DUF641) Filament PF00038.16 ESL11544.1 - 0.0044 16.5 14.1 0.056 12.9 5.4 2.2 2 0 0 2 2 2 2 Intermediate filament protein KLRAQ PF10205.4 ESL11544.1 - 0.014 15.4 9.9 5.5 7.0 0.1 3.4 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein Sipho_Gp157 PF05565.6 ESL11544.1 - 0.035 13.6 3.4 0.24 10.9 0.6 2.4 1 1 1 2 2 2 0 Siphovirus Gp157 APG6 PF04111.7 ESL11544.1 - 0.04 12.9 8.2 0.072 12.1 5.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IFT57 PF10498.4 ESL11544.1 - 0.042 12.5 8.2 0.042 12.5 2.8 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Arena_RNA_pol PF06317.6 ESL11544.1 - 0.049 10.2 0.8 0.052 10.1 0.5 1.0 1 0 0 1 1 1 0 Arenavirus RNA polymerase SlyX PF04102.7 ESL11544.1 - 0.35 11.2 5.7 0.55 10.6 0.2 3.0 2 1 1 3 3 3 0 SlyX ING PF12998.2 ESL11544.1 - 1.7 8.9 9.1 3.5 7.9 2.6 3.0 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding TMF_TATA_bd PF12325.3 ESL11544.1 - 2.1 8.0 11.4 0.27 10.9 4.7 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding TBPIP PF07106.8 ESL11544.1 - 2.9 7.4 9.0 0.21 11.1 2.5 1.8 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tropomyosin_1 PF12718.2 ESL11544.1 - 5.3 6.8 13.2 3 7.7 6.6 2.0 2 0 0 2 2 2 0 Tropomyosin like YlqD PF11068.3 ESL11544.1 - 7.7 6.5 8.7 5.9 6.9 3.7 2.2 2 0 0 2 2 2 0 YlqD protein TIP49 PF06068.8 ESL11546.1 - 5.1e-186 618.1 2.0 5.9e-186 617.9 1.4 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 ESL11546.1 - 2.8e-12 46.9 1.5 4.2e-07 30.2 0.0 3.6 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESL11546.1 - 1.5e-11 43.8 0.8 9.9e-08 31.3 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESL11546.1 - 1.6e-06 28.2 0.2 0.043 13.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESL11546.1 - 3.2e-06 27.2 0.1 0.00091 19.2 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESL11546.1 - 0.0006 19.5 0.2 0.1 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 ESL11546.1 - 0.00067 19.1 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL11546.1 - 0.0012 18.5 0.1 0.0046 16.6 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain Mg_chelatase PF01078.16 ESL11546.1 - 0.0024 17.0 0.4 0.13 11.4 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 ESL11546.1 - 0.0034 18.1 0.1 0.012 16.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESL11546.1 - 0.004 16.5 0.6 0.023 14.0 0.1 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.1 ESL11546.1 - 0.0056 16.5 0.1 0.02 14.7 0.0 2.0 3 0 0 3 3 2 1 AAA domain AAA_11 PF13086.1 ESL11546.1 - 0.0064 16.0 0.2 0.053 13.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESL11546.1 - 0.0067 16.3 0.1 2.1 8.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESL11546.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESL11546.1 - 0.016 15.5 0.7 0.1 12.9 0.1 2.4 2 1 0 2 2 2 0 AAA domain ResIII PF04851.10 ESL11546.1 - 0.048 13.4 1.3 1.7 8.4 0.1 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DnaB_C PF03796.10 ESL11546.1 - 0.067 12.0 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Zeta_toxin PF06414.7 ESL11546.1 - 0.083 11.9 0.1 0.23 10.5 0.1 1.7 1 0 0 1 1 1 0 Zeta toxin SUR7 PF06687.7 ESL11547.1 - 0.0026 17.3 17.6 0.12 11.9 0.8 3.4 2 1 0 2 2 2 2 SUR7/PalI family Tweety PF04906.8 ESL11547.1 - 0.0051 15.2 0.8 0.0051 15.2 0.5 2.2 2 0 0 2 2 2 1 Tweety DUF663 PF04950.7 ESL11550.1 - 1.1e-80 270.7 0.0 1.6e-80 270.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 ESL11550.1 - 2.2e-19 68.7 0.0 4.7e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain PH PF00169.24 ESL11551.1 - 0.0032 17.6 0.0 0.0086 16.2 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESL11551.1 - 0.083 13.1 0.1 0.29 11.4 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain WD40 PF00400.27 ESL11552.1 - 7.5e-26 89.0 21.9 6.8e-05 22.5 0.0 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 ESL11552.1 - 0.00082 17.6 1.4 0.013 13.6 1.0 2.6 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESL11552.1 - 0.038 12.7 0.1 0.42 9.3 0.0 2.5 1 1 2 3 3 3 0 Nup133 N terminal like Atg14 PF10186.4 ESL11552.1 - 0.058 12.3 21.3 0.12 11.2 6.3 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DivIVA PF05103.8 ESL11552.1 - 0.24 11.4 21.1 0.029 14.4 7.5 3.1 1 1 2 3 3 3 0 DivIVA protein Cir_Bir_Yir PF06022.6 ESL11552.1 - 0.35 10.0 2.4 0.51 9.5 1.7 1.2 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir DUF4101 PF13355.1 ESL11552.1 - 1.9 8.9 7.8 0.57 10.6 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4101) Mod_r PF07200.8 ESL11552.1 - 4.9 7.0 18.8 1.3 8.9 9.0 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein JAB PF01398.16 ESL11553.1 - 3.2e-07 30.0 0.0 7.1e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ERM PF00769.14 ESL11553.1 - 0.0083 15.6 1.7 0.0083 15.6 1.2 1.6 2 0 0 2 2 2 1 Ezrin/radixin/moesin family Fib_alpha PF08702.5 ESL11553.1 - 0.0093 16.0 0.6 0.021 14.9 0.4 1.5 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF2242 PF10001.4 ESL11553.1 - 0.12 12.2 0.2 0.58 10.0 0.0 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2242) TMEM247 PF15444.1 ESL11554.1 - 6.4 6.5 6.3 13 5.4 4.4 1.5 1 0 0 1 1 1 0 Transmembrane protein 247 HPP PF04982.8 ESL11555.1 - 0.00062 19.5 3.7 0.00083 19.1 2.6 1.3 1 0 0 1 1 1 1 HPP family SecE PF00584.15 ESL11555.1 - 0.17 11.5 2.6 1.3 8.6 0.5 2.4 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex GMC_oxred_N PF00732.14 ESL11556.1 - 8.7e-42 143.2 0.0 1.2e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 ESL11556.1 - 9.8e-19 68.0 0.3 1.6e-18 67.3 0.2 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 ESL11556.1 - 9.6e-06 24.7 2.1 0.0078 15.1 0.0 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESL11556.1 - 0.00038 19.4 7.3 0.051 12.4 0.9 2.6 3 0 0 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.7 ESL11556.1 - 0.013 14.4 0.6 0.038 12.9 0.2 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_oxidored PF12831.2 ESL11556.1 - 0.026 13.5 3.0 0.99 8.4 1.1 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESL11556.1 - 0.027 14.3 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESL11556.1 - 0.041 13.9 0.0 3.9 7.4 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESL11556.1 - 0.066 13.2 6.4 0.076 13.0 0.4 3.3 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 ESL11556.1 - 0.22 9.9 0.3 0.4 9.1 0.2 1.4 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.17 ESL11556.1 - 0.32 9.8 2.0 0.48 9.2 1.4 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A MFS_1 PF07690.11 ESL11557.1 - 6.4e-11 41.5 39.5 4.6e-09 35.4 19.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1673 PF07895.6 ESL11557.1 - 0.33 10.4 4.5 0.34 10.4 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) DUF3096 PF11295.3 ESL11557.1 - 8 6.0 14.3 1.2 8.6 1.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3096) Pribosyltran PF00156.22 ESL11558.1 - 3.5e-11 42.8 0.0 4.6e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESL11558.1 - 0.089 11.9 0.0 0.093 11.9 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Arf PF00025.16 ESL11559.1 - 1.2e-64 216.7 0.0 1.4e-64 216.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESL11559.1 - 3e-14 52.5 0.1 5.4e-12 45.0 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 ESL11559.1 - 2.3e-13 49.7 0.0 2.8e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 ESL11559.1 - 1.3e-11 44.1 0.0 1.6e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 ESL11559.1 - 4.7e-10 38.9 0.0 5.7e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESL11559.1 - 1.5e-08 35.1 0.0 1.9e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESL11559.1 - 2.6e-06 27.3 0.0 3.3e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 ESL11559.1 - 0.0097 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase NACHT PF05729.7 ESL11559.1 - 0.011 15.4 0.3 0.047 13.3 0.2 1.9 1 1 0 1 1 1 0 NACHT domain AAA_33 PF13671.1 ESL11559.1 - 0.023 14.5 0.1 0.028 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 ESL11559.1 - 0.038 13.4 0.0 0.11 11.9 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.1 ESL11559.1 - 0.086 12.7 0.0 6.1 6.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain FbpA PF05833.6 ESL11560.1 - 5.9e-33 114.0 4.3 5.9e-33 114.0 3.0 2.6 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.3 ESL11560.1 - 6.3e-22 77.3 2.4 2.1e-21 75.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 ESL11560.1 - 6.6e-07 29.1 0.1 2.1e-05 24.2 0.1 3.0 1 1 0 1 1 1 1 Domain of unknown function (DUF814) Actin PF00022.14 ESL11561.1 - 0.0065 14.9 0.1 0.012 14.0 0.1 1.4 1 0 0 1 1 1 1 Actin Ribosomal_L6 PF00347.18 ESL11562.1 - 1.1e-07 32.2 0.0 1.1e-07 32.2 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L6 Arf PF00025.16 ESL11563.1 - 5.9e-15 54.9 0.0 1.1e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESL11563.1 - 0.0001 21.6 0.0 0.00049 19.3 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Miro PF08477.8 ESL11563.1 - 0.0013 19.2 0.1 0.043 14.3 0.0 2.9 3 0 0 3 3 3 1 Miro-like protein MMR_HSR1 PF01926.18 ESL11563.1 - 0.0019 18.1 0.0 0.01 15.8 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase Vps23_core PF09454.5 ESL11563.1 - 0.06 12.9 0.4 0.18 11.4 0.2 1.8 1 0 0 1 1 1 0 Vps23 core domain PBP PF01161.15 ESL11563.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein G-alpha PF00503.15 ESL11563.1 - 0.18 10.4 0.1 0.29 9.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit DnaJ PF00226.26 ESL11564.1 - 4.1e-10 39.2 0.0 9e-10 38.1 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain HTH_38 PF13936.1 ESL11564.1 - 0.00026 20.4 0.0 0.00071 19.0 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESL11564.1 - 0.0037 16.8 2.0 0.027 14.1 0.0 3.0 3 1 0 3 3 3 1 Homeodomain-like domain KorB PF08535.5 ESL11564.1 - 0.0051 16.9 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 KorB domain HTH_Tnp_ISL3 PF13542.1 ESL11564.1 - 0.02 14.0 0.1 0.087 12.0 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_AsnC-type PF13404.1 ESL11564.1 - 0.074 12.6 0.5 0.66 9.5 0.0 2.5 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_29 PF13551.1 ESL11564.1 - 0.24 11.5 6.1 0.12 12.4 0.8 2.9 3 0 0 3 3 3 0 Winged helix-turn helix DUF3744 PF12558.3 ESL11565.1 - 0.081 13.3 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 ATP-binding cassette cobalt transporter DUF904 PF06005.7 ESL11566.1 - 0.1 12.9 3.0 8.9 6.6 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF904) MscS_porin PF12795.2 ESL11566.1 - 2.3 7.4 9.5 4.1 6.6 3.0 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DAGK_cat PF00781.19 ESL11568.1 - 1.2e-14 53.8 0.0 1.2e-11 44.1 0.0 2.5 2 0 0 2 2 2 2 Diacylglycerol kinase catalytic domain Prok-RING_2 PF14445.1 ESL11569.1 - 0.014 15.3 0.3 0.029 14.3 0.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 EF-hand_1 PF00036.27 ESL11570.1 - 0.0034 16.5 0.0 0.36 10.2 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 ESL11570.1 - 0.006 16.6 0.0 0.018 15.1 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 ESL11570.1 - 0.0079 15.9 0.0 0.42 10.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 ESL11570.1 - 0.021 14.4 0.0 0.3 10.7 0.0 2.5 2 1 1 3 3 3 0 EF-hand domain pair SAG PF04092.8 ESL11571.1 - 1.1 9.6 5.4 0.37 11.1 0.3 2.3 2 0 0 2 2 2 0 SRS domain AATF-Che1 PF13339.1 ESL11573.1 - 4.6e-11 43.0 0.0 4.6e-11 43.0 0.0 4.1 2 2 2 4 4 4 1 Apoptosis antagonizing transcription factor BAR_2 PF10455.4 ESL11573.1 - 0.026 13.4 0.1 0.057 12.3 0.1 1.4 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Col_cuticle_N PF01484.12 ESL11573.1 - 0.12 12.0 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain V_ATPase_I PF01496.14 ESL11573.1 - 0.5 8.1 2.7 0.16 9.8 0.1 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family MFS_1 PF07690.11 ESL11574.1 - 6e-40 137.0 40.9 2.3e-20 72.6 7.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.11 ESL11574.1 - 0.011 15.1 2.6 0.011 15.1 1.8 2.2 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 EF-hand_1 PF00036.27 ESL11576.1 - 0.0015 17.7 0.0 0.0042 16.2 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 ESL11576.1 - 0.015 15.4 0.0 0.049 13.7 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 ESL11576.1 - 0.028 14.2 0.0 0.087 12.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain tRNA-synt_1c PF00749.16 ESL11577.1 - 8.3e-99 330.1 0.0 1.1e-98 329.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 ESL11577.1 - 6.7e-41 139.8 0.1 1e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain WD40 PF00400.27 ESL11580.1 - 1.4e-12 46.9 1.7 0.00039 20.1 0.0 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESL11580.1 - 9.6e-08 31.2 0.2 0.0014 17.5 0.0 3.1 2 1 1 3 3 3 2 Coatomer WD associated region TPR_12 PF13424.1 ESL11580.1 - 0.00015 21.6 6.0 0.096 12.6 0.1 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat eIF2A PF08662.6 ESL11580.1 - 0.00088 19.0 0.2 0.41 10.3 0.1 3.3 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A TPR_1 PF00515.23 ESL11580.1 - 0.002 17.6 7.3 0.93 9.2 0.3 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat Clathrin PF00637.15 ESL11580.1 - 0.0076 15.8 0.7 12 5.5 0.0 3.7 2 2 1 3 3 3 0 Region in Clathrin and VPS TPR_2 PF07719.12 ESL11580.1 - 0.014 15.2 15.7 0.18 11.8 0.3 5.8 7 2 1 8 8 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESL11580.1 - 0.025 14.3 12.3 0.58 10.0 0.3 5.3 6 1 1 7 7 5 0 Tetratricopeptide repeat RPN7 PF10602.4 ESL11580.1 - 0.025 13.9 3.2 0.1 11.9 0.0 2.7 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_14 PF13428.1 ESL11580.1 - 0.032 14.8 13.1 0.95 10.2 0.4 5.5 6 0 0 6 6 4 0 Tetratricopeptide repeat Vps39_1 PF10366.4 ESL11580.1 - 0.064 13.2 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 TPR_11 PF13414.1 ESL11580.1 - 0.07 12.7 10.8 0.09 12.4 0.1 4.2 5 0 0 5 5 5 0 TPR repeat TPR_8 PF13181.1 ESL11580.1 - 0.19 11.6 4.2 0.61 9.9 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11580.1 - 0.19 12.0 6.3 2.8 8.3 0.5 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat zf-ribbon_3 PF13248.1 ESL11580.1 - 0.58 9.4 6.2 1.6 8.0 0.7 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 ESL11580.1 - 1 9.2 11.8 14 5.5 8.3 2.5 1 1 0 1 1 1 0 Double zinc ribbon TPR_6 PF13174.1 ESL11580.1 - 2.1 9.0 7.9 13 6.5 0.3 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESL11580.1 - 7.2 6.6 9.6 18 5.4 0.0 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat zf-RanBP PF00641.13 ESL11580.1 - 8.6 5.5 10.8 4.5 6.4 2.7 2.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Bd3614_N PF14442.1 ESL11582.1 - 0.14 12.1 6.8 0.54 10.2 0.0 3.2 3 0 0 3 3 3 0 Bd3614-like deaminase N-terminal ABC_tran PF00005.22 ESL11583.1 - 3e-36 124.7 0.0 3.4e-17 63.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 ESL11583.1 - 4.4e-16 59.6 1.7 2.4e-06 27.7 0.5 4.3 2 2 1 3 3 3 2 AAA domain SMC_N PF02463.14 ESL11583.1 - 3.9e-12 45.8 2.0 0.0066 15.7 0.0 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain RLI PF04068.10 ESL11583.1 - 3.3e-10 39.3 3.5 8e-10 38.1 2.4 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_15 PF13175.1 ESL11583.1 - 1.8e-09 37.1 0.0 0.029 13.4 0.0 4.3 4 0 0 4 4 4 2 AAA ATPase domain Fer4 PF00037.22 ESL11583.1 - 2.7e-09 36.2 1.9 2.7e-09 36.2 1.3 3.0 4 0 0 4 4 2 1 4Fe-4S binding domain Fer4_6 PF12837.2 ESL11583.1 - 2.5e-06 27.1 1.0 2.5e-06 27.1 0.7 3.2 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_22 PF13401.1 ESL11583.1 - 3.2e-06 27.2 0.7 0.00055 20.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESL11583.1 - 3.7e-06 26.3 0.0 0.011 15.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 ESL11583.1 - 2.2e-05 24.9 0.0 0.0043 17.5 0.0 3.0 3 0 0 3 3 2 1 Miro-like protein AAA_23 PF13476.1 ESL11583.1 - 4.7e-05 23.8 1.1 0.018 15.3 0.2 2.5 2 0 0 2 2 2 1 AAA domain Fer4_7 PF12838.2 ESL11583.1 - 7.9e-05 22.9 12.8 9.9e-05 22.6 0.1 3.2 3 0 0 3 3 3 1 4Fe-4S dicluster domain AAA_16 PF13191.1 ESL11583.1 - 0.00011 22.2 1.1 0.033 14.1 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 ESL11583.1 - 0.00023 21.3 0.0 0.045 13.9 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ESL11583.1 - 0.00024 20.8 0.7 0.011 15.3 0.0 2.7 3 0 0 3 3 2 1 NACHT domain VirE PF05272.6 ESL11583.1 - 0.00032 20.2 0.1 0.094 12.1 0.0 2.5 2 0 0 2 2 2 1 Virulence-associated protein E AAA_28 PF13521.1 ESL11583.1 - 0.00033 20.6 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.2 ESL11583.1 - 0.00041 20.0 2.0 0.00041 20.0 1.4 3.6 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_14 PF13173.1 ESL11583.1 - 0.00063 19.6 0.6 0.14 12.0 0.0 3.3 2 1 1 3 3 3 1 AAA domain Fer4_10 PF13237.1 ESL11583.1 - 0.00082 19.1 1.3 0.00082 19.1 0.9 2.9 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 ESL11583.1 - 0.00085 19.1 13.7 0.00085 19.1 9.5 2.0 2 0 0 2 2 1 1 4Fe-4S dicluster domain AAA_33 PF13671.1 ESL11583.1 - 0.00094 19.0 0.0 0.34 10.7 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.1 ESL11583.1 - 0.0011 18.4 0.1 0.92 8.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 ESL11583.1 - 0.0012 18.4 0.0 0.013 15.1 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 DUF258 PF03193.11 ESL11583.1 - 0.0018 17.4 4.2 0.059 12.5 0.0 2.7 3 0 0 3 3 2 1 Protein of unknown function, DUF258 AAA_13 PF13166.1 ESL11583.1 - 0.002 16.6 0.2 0.043 12.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESL11583.1 - 0.0028 17.8 0.5 0.89 9.7 0.0 3.1 4 0 0 4 4 2 1 RNA helicase Fer4_3 PF12798.2 ESL11583.1 - 0.0033 17.8 5.2 0.0033 17.8 3.6 3.1 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_17 PF13207.1 ESL11583.1 - 0.0035 18.1 1.1 4.6 8.0 0.2 3.2 2 2 0 2 2 2 0 AAA domain Septin PF00735.13 ESL11583.1 - 0.0036 16.3 0.0 1.1 8.2 0.0 2.9 3 0 0 3 3 3 1 Septin SRP54 PF00448.17 ESL11583.1 - 0.0049 16.3 0.4 0.49 9.7 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_16 PF13484.1 ESL11583.1 - 0.0076 16.9 0.2 0.0076 16.9 0.1 2.8 3 0 0 3 3 2 1 4Fe-4S double cluster binding domain Fer4_4 PF12800.2 ESL11583.1 - 0.008 16.4 2.0 0.008 16.4 1.4 3.4 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_5 PF07728.9 ESL11583.1 - 0.011 15.4 0.3 0.78 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 ESL11583.1 - 0.013 15.3 0.0 3.1 7.7 0.0 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Fer4_9 PF13187.1 ESL11583.1 - 0.014 15.6 16.1 0.019 15.2 9.4 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_18 PF13238.1 ESL11583.1 - 0.015 15.6 0.6 10 6.4 0.0 3.1 2 2 0 2 2 2 0 AAA domain MobB PF03205.9 ESL11583.1 - 0.017 14.8 0.3 2.5 7.7 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.10 ESL11583.1 - 0.021 13.5 0.0 1.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein MMR_HSR1 PF01926.18 ESL11583.1 - 0.04 13.8 0.2 3.3 7.6 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.1 ESL11583.1 - 0.05 13.1 0.0 3.7 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 ESL11583.1 - 0.09 12.5 0.9 25 4.7 0.0 3.2 3 0 0 3 3 3 0 Part of AAA domain Arch_ATPase PF01637.13 ESL11583.1 - 0.097 12.3 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase PduV-EutP PF10662.4 ESL11583.1 - 0.13 11.7 1.4 0.34 10.3 0.0 2.3 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.17 ESL11583.1 - 0.15 10.9 0.2 5.5 5.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Fer4_17 PF13534.1 ESL11583.1 - 0.48 10.8 16.4 18 5.7 9.6 3.3 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESL11583.1 - 0.58 10.2 14.6 2.6 8.1 8.3 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain ER_lumen_recept PF00810.13 ESL11584.1 - 7.5e-54 182.2 7.6 1.3e-53 181.3 5.3 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor Enolase_N PF03952.11 ESL11585.1 - 1.5e-11 44.3 0.0 3.2e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain Enolase_C PF00113.17 ESL11585.1 - 0.00021 20.3 0.1 0.00042 19.3 0.0 1.4 1 1 0 1 1 1 1 Enolase, C-terminal TIM barrel domain F420_ligase PF01996.11 ESL11585.1 - 0.033 13.2 0.7 0.063 12.3 0.0 1.8 2 1 0 2 2 2 0 F420-0:Gamma-glutamyl ligase DUF2399 PF09664.5 ESL11585.1 - 0.11 12.3 0.3 4.9 7.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2399) UBA PF00627.26 ESL11586.1 - 2.7e-05 23.8 0.1 4.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Rhomboid PF01694.17 ESL11586.1 - 0.003 17.5 0.5 0.0064 16.5 0.3 1.6 1 1 0 1 1 1 1 Rhomboid family CUE PF02845.11 ESL11586.1 - 0.013 14.9 0.1 0.032 13.7 0.0 1.7 2 0 0 2 2 2 0 CUE domain HSP70 PF00012.15 ESL11587.1 - 2.5e-78 263.4 0.1 1.5e-77 260.9 0.0 1.9 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESL11587.1 - 2.3e-05 23.1 0.1 0.0023 16.6 0.0 2.9 2 1 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 ESL11587.1 - 0.00032 20.3 0.0 0.0015 18.1 0.0 2.1 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 ESL11587.1 - 0.0055 15.5 0.0 1 8.1 0.0 2.3 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.1 ESL11587.1 - 0.033 14.0 0.0 31 4.4 0.0 3.6 3 1 0 3 3 3 0 Cell division protein FtsA HAUS-augmin3 PF14932.1 ESL11587.1 - 0.54 9.4 7.6 0.064 12.4 1.6 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Tmemb_185A PF10269.4 ESL11588.1 - 1.3e-38 132.9 13.9 1.3e-38 132.9 9.7 1.7 2 1 0 2 2 2 1 Transmembrane Fragile-X-F protein DnaJ PF00226.26 ESL11588.1 - 2.4e-20 72.0 0.6 6.5e-20 70.6 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain eIF-5a PF01287.15 ESL11590.1 - 6.7e-27 93.2 0.1 1e-26 92.6 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 ESL11590.1 - 4.7e-05 23.1 0.1 0.00012 21.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain Exo_endo_phos PF03372.18 ESL11591.1 - 5.4e-12 46.1 0.1 7.6e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HTH_Tnp_IS1 PF12759.2 ESL11591.1 - 0.05 13.0 0.1 0.098 12.0 0.1 1.4 1 0 0 1 1 1 0 InsA C-terminal domain Shadoo PF14999.1 ESL11591.1 - 2.2 8.1 6.2 0.83 9.5 2.3 1.7 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective GATase PF00117.23 ESL11592.1 - 1.7e-10 40.6 0.0 2.4e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESL11592.1 - 1.5e-06 27.8 1.3 2.4e-05 23.8 0.2 2.7 2 1 0 2 2 2 1 Peptidase C26 Histone PF00125.19 ESL11594.1 - 8.3e-18 64.2 0.6 1.1e-17 63.8 0.4 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL11594.1 - 0.00019 21.3 0.2 0.00039 20.4 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ClpB_D2-small PF10431.4 ESL11594.1 - 0.066 13.1 0.1 0.72 9.7 0.1 2.1 1 1 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein Tyr-DNA_phospho PF06087.7 ESL11595.1 - 6.1e-91 305.2 0.0 7e-91 305.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 ESL11595.1 - 0.025 14.3 0.0 0.088 12.5 0.0 1.8 2 0 0 2 2 2 0 PLD-like domain Cpn60_TCP1 PF00118.19 ESL11596.1 - 7.6e-141 470.0 8.2 8.7e-141 469.8 5.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CMS1 PF14617.1 ESL11596.1 - 0.0091 15.0 0.4 0.05 12.6 0.2 2.1 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit RNA_pol_Rpb6 PF01192.17 ESL11597.1 - 1.5e-11 43.8 0.1 1.1e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb6 PRKCSH PF07915.8 ESL11599.1 - 1.2e-10 42.0 0.0 4.1e-10 40.3 0.0 1.9 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein COP23 PF14218.1 ESL11599.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Circadian oscillating protein COP23 Sec23_trunk PF04811.10 ESL11601.1 - 7.8e-45 153.1 0.0 7.8e-44 149.8 0.0 2.1 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 ESL11601.1 - 2.6e-24 84.6 0.0 5e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESL11601.1 - 1.7e-20 73.3 0.0 3.4e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 ESL11601.1 - 2.8e-06 26.9 0.0 1.2e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.10 ESL11601.1 - 0.00045 19.7 8.9 0.0011 18.4 6.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger OrfB_Zn_ribbon PF07282.6 ESL11601.1 - 0.048 13.3 2.2 0.099 12.3 1.5 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Prok-RING_1 PF14446.1 ESL11601.1 - 0.58 9.9 3.8 1.5 8.6 2.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DEAD PF00270.24 ESL11602.1 - 9.6e-26 90.2 0.7 1.6e-25 89.5 0.2 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL11602.1 - 1.7e-18 66.2 0.0 3.5e-17 62.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL11602.1 - 0.011 15.5 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 ESL11602.1 - 0.1 11.8 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain Peptidase_M8 PF01457.11 ESL11603.1 - 2.6e-24 85.4 0.0 3.1e-24 85.2 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Mito_carr PF00153.22 ESL11604.1 - 1.4e-05 24.6 5.0 0.00024 20.7 0.2 3.2 3 0 0 3 3 3 2 Mitochondrial carrier protein Dynein_heavy PF03028.10 ESL11605.1 - 1.2e-97 327.7 0.0 4.8e-96 322.3 0.0 2.3 1 1 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 ESL11605.1 - 4.1e-32 110.8 0.0 9.9e-32 109.6 0.0 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESL11605.1 - 2e-27 95.8 0.2 2.8e-27 95.4 0.1 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Phlebovirus_NSM PF07246.6 ESL11605.1 - 0.34 10.0 1.5 6.8 5.7 0.1 2.3 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M DUF1664 PF07889.7 ESL11605.1 - 1.4 8.7 4.1 12 5.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FYRC PF05965.9 ESL11606.1 - 3.7e-08 33.0 0.0 7.2e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus PEP-utilizers PF00391.18 ESL11606.1 - 0.02 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain DUF1610 PF07754.6 ESL11606.1 - 1.2 9.2 3.2 0.79 9.9 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) PAPS_reduct PF01507.14 ESL11607.1 - 7.4e-19 68.2 0.0 3e-13 49.9 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family Ras PF00071.17 ESL11608.1 - 1e-49 168.0 0.1 1.1e-49 167.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL11608.1 - 3.3e-23 82.4 0.1 3.8e-23 82.2 0.0 1.0 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL11608.1 - 5.8e-15 54.9 0.1 6.8e-15 54.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL11608.1 - 1.6e-06 27.4 0.0 1.8e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESL11608.1 - 7.6e-06 25.8 0.0 9.6e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESL11608.1 - 0.00011 22.2 0.0 0.00045 20.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESL11608.1 - 0.00041 19.6 0.0 0.00053 19.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ESL11608.1 - 0.00055 19.9 0.0 0.00065 19.7 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.22 ESL11608.1 - 0.00072 19.0 0.1 0.004 16.5 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESL11608.1 - 0.0034 16.6 0.1 0.0065 15.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Septin PF00735.13 ESL11608.1 - 0.0042 16.1 0.0 0.0061 15.6 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_24 PF13479.1 ESL11608.1 - 0.0044 16.6 0.1 0.016 14.8 0.1 1.8 1 1 1 2 2 2 1 AAA domain PduV-EutP PF10662.4 ESL11608.1 - 0.0051 16.3 0.0 0.013 14.9 0.0 1.7 1 1 1 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 ESL11608.1 - 0.015 15.0 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 ESL11608.1 - 0.017 15.4 0.1 0.019 15.2 0.0 1.4 1 1 0 1 1 1 0 ABC transporter MCM PF00493.18 ESL11608.1 - 0.018 13.8 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family DUF815 PF05673.8 ESL11608.1 - 0.03 13.2 0.0 0.048 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.1 ESL11608.1 - 0.033 13.7 0.0 0.079 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.11 ESL11608.1 - 0.034 13.2 0.0 0.043 12.9 0.0 1.3 1 1 0 1 1 1 0 AIG1 family AAA_5 PF07728.9 ESL11608.1 - 0.035 13.8 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ESL11608.1 - 0.061 12.4 0.0 0.35 9.9 0.0 2.1 1 1 0 1 1 1 0 Zeta toxin Dynamin_N PF00350.18 ESL11608.1 - 0.089 12.6 0.0 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.15 ESL11608.1 - 0.093 11.4 1.4 0.45 9.1 0.3 2.1 1 1 1 2 2 2 0 G-protein alpha subunit AAA_10 PF12846.2 ESL11608.1 - 0.13 11.7 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain DUF3128 PF11326.3 ESL11609.1 - 3.9e-14 52.5 1.5 2.1e-13 50.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) HYLS1_C PF15311.1 ESL11609.1 - 0.0002 21.5 1.9 0.0002 21.5 1.3 2.3 2 0 0 2 2 2 1 Hydrolethalus syndrome protein 1 C-terminus SRRM_C PF15230.1 ESL11609.1 - 0.027 14.5 7.3 0.082 13.0 5.1 1.8 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus Rab5ip PF07019.7 ESL11610.1 - 1.5e-18 66.7 4.7 1.8e-18 66.4 3.2 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Aph-1 PF06105.7 ESL11610.1 - 0.05 12.8 0.7 0.075 12.2 0.5 1.2 1 0 0 1 1 1 0 Aph-1 protein BTP PF05232.7 ESL11610.1 - 2.8 7.7 6.9 11 5.8 0.6 2.2 2 0 0 2 2 2 0 Bacterial Transmembrane Pair family zf-SNAP50_C PF12251.3 ESL11611.1 - 1.2e-57 194.4 0.1 1.6e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal LysM PF01476.15 ESL11611.1 - 0.17 11.7 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 LysM domain DNA_ligase_A_M PF01068.16 ESL11613.1 - 6.1e-08 32.2 0.0 0.001 18.4 0.0 2.7 3 0 0 3 3 3 2 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.1 ESL11613.1 - 0.015 14.9 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 DNA ligase OB-like domain Cpn60_TCP1 PF00118.19 ESL11614.1 - 3e-137 458.1 4.7 3.4e-137 458.0 3.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Kinesin PF00225.18 ESL11615.1 - 1.6e-26 92.8 0.0 2.2e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain MORN PF02493.15 ESL11615.1 - 1.8e-18 65.0 31.8 5.1e-05 22.7 0.1 7.0 7 0 0 7 7 7 6 MORN repeat zf-CCCH PF00642.19 ESL11616.1 - 0.005 16.4 1.8 0.005 16.4 1.3 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nuc_deoxyrib_tr PF05014.10 ESL11617.1 - 1.9e-31 108.2 0.0 2.5e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase DUF4406 PF14359.1 ESL11617.1 - 6.1e-05 23.0 0.0 9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4406) TIR_2 PF13676.1 ESL11617.1 - 0.0024 17.9 0.0 0.0036 17.4 0.0 1.2 1 0 0 1 1 1 1 TIR domain DUF2872 PF11071.3 ESL11617.1 - 0.027 14.3 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2872) IQ PF00612.22 ESL11618.1 - 5.9e-23 78.2 186.3 7.1e-05 22.1 1.2 26.6 27 0 0 27 27 27 16 IQ calmodulin-binding motif TPR_12 PF13424.1 ESL11618.1 - 1.9e-10 40.5 4.0 7.8e-09 35.3 0.1 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL11618.1 - 3.5e-08 32.9 4.4 2e-06 27.3 0.1 4.8 4 0 0 4 4 4 1 TPR repeat TPR_10 PF13374.1 ESL11618.1 - 0.0002 21.1 0.3 0.0002 21.1 0.2 6.7 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11618.1 - 0.22 11.2 9.9 1.5 8.5 0.0 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11618.1 - 1.5 8.8 20.3 0.9 9.6 0.1 7.1 6 1 0 6 6 6 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL11619.1 - 8.9e-48 162.6 0.0 3.4e-47 160.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11619.1 - 3.6e-26 91.7 0.0 3.2e-25 88.6 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 ESL11619.1 - 9.6e-08 32.1 0.0 2.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 ESL11619.1 - 0.0012 17.8 0.0 0.0019 17.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PH_4 PF15404.1 ESL11619.1 - 0.0063 16.0 0.0 0.041 13.4 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.1 ESL11619.1 - 0.019 15.1 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.1 ESL11619.1 - 0.031 14.5 0.0 0.086 13.0 0.0 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain BolA PF01722.13 ESL11620.1 - 4.6e-14 52.1 0.0 5.6e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein Oscp1 PF10188.4 ESL11621.1 - 2.8e-59 199.8 0.4 3.8e-59 199.4 0.3 1.2 1 0 0 1 1 1 1 Organic solute transport protein 1 DUF1751 PF08551.5 ESL11621.1 - 0.26 11.6 1.3 8.3 6.8 0.0 2.5 2 1 1 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) Katanin_con80 PF13925.1 ESL11623.1 - 4.7e-34 117.4 0.0 7e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 con80 domain of Katanin Phage_Capsid_P3 PF09018.6 ESL11623.1 - 0.082 11.4 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 P3 major capsid protein MORN PF02493.15 ESL11626.1 - 1.5e-27 93.6 36.0 1.2e-06 27.9 1.6 7.7 7 0 0 7 7 7 6 MORN repeat Afi1 PF07792.7 ESL11626.1 - 3.3 7.6 5.5 1.1 9.2 0.9 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking GEMIN8 PF15348.1 ESL11626.1 - 8.6 6.3 15.8 0.19 11.7 4.7 2.5 3 0 0 3 3 3 0 Gemini of Cajal bodies-associated protein 8 PPR_3 PF13812.1 ESL11627.1 - 0.0014 18.7 0.2 5.7 7.4 0.0 3.6 4 0 0 4 4 4 2 Pentatricopeptide repeat domain DEAD PF00270.24 ESL11628.1 - 5.9e-41 139.7 0.0 1.1e-40 138.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL11628.1 - 2.3e-20 72.2 0.0 5.6e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESL11628.1 - 9.7e-14 50.6 0.8 1.9e-13 49.7 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESL11628.1 - 0.0079 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ebp2 PF05890.7 ESL11629.1 - 1.1e-47 162.5 6.3 1.8e-47 161.9 4.3 1.2 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 DUF3840 PF12944.2 ESL11629.1 - 0.028 14.2 0.4 0.064 13.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3840) U79_P34 PF03064.11 ESL11629.1 - 7.4 6.0 10.7 11 5.4 7.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 ADH_zinc_N PF00107.21 ESL11630.1 - 1.4e-21 76.3 0.1 1.9e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESL11630.1 - 8e-19 68.7 0.0 1.3e-18 68.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase zf-LYAR PF08790.6 ESL11631.1 - 1.1e-13 50.5 6.2 1.1e-13 50.5 4.3 2.2 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-DNL PF05180.7 ESL11631.1 - 0.0016 18.0 3.6 0.0029 17.3 2.5 1.4 1 0 0 1 1 1 1 DNL zinc finger DM PF00751.13 ESL11631.1 - 0.29 10.7 1.9 0.62 9.6 1.3 1.5 1 0 0 1 1 1 0 DM DNA binding domain Ribosomal_L37ae PF01780.14 ESL11632.1 - 2e-36 123.6 5.0 2.2e-36 123.5 3.4 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family C1_1 PF00130.17 ESL11632.1 - 0.0022 17.7 2.5 0.0032 17.1 1.7 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.5 ESL11632.1 - 0.0062 15.9 0.7 1.8 8.1 0.0 2.1 2 0 0 2 2 2 2 A2L zinc ribbon domain Carla_C4 PF01623.12 ESL11632.1 - 0.079 12.7 1.2 0.096 12.4 0.9 1.3 1 1 0 1 1 1 0 Carlavirus putative nucleic acid binding protein NOB1_Zn_bind PF08772.6 ESL11632.1 - 0.11 12.3 4.2 1.3 8.8 2.9 2.2 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Zn_Tnp_IS1595 PF12760.2 ESL11632.1 - 0.11 12.2 2.5 0.17 11.6 1.7 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.8 ESL11632.1 - 6.2 6.4 6.9 1.2 8.7 2.1 1.8 2 0 0 2 2 2 0 ClpX C4-type zinc finger GTP_EFTU PF00009.22 ESL11634.1 - 7.5e-45 152.6 0.0 1.1e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 ESL11634.1 - 1.5e-29 102.0 1.3 2.6e-29 101.2 0.9 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 ESL11634.1 - 1.3e-14 53.7 0.0 2.7e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 ESL11634.1 - 0.00025 20.9 0.0 0.0005 20.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 ESL11634.1 - 0.0023 17.3 0.0 0.0044 16.4 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ESL11634.1 - 0.042 13.0 0.0 0.094 11.9 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cNMP_binding PF00027.24 ESL11637.1 - 9.1e-09 35.0 0.0 3.8e-08 33.0 0.0 2.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF1227 PF06777.6 ESL11637.1 - 0.0061 16.2 0.0 0.018 14.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) PCI_Csn8 PF10075.4 ESL11638.1 - 6.3e-34 116.7 0.0 1.1e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 ESL11638.1 - 3.3e-27 95.3 0.5 4.8e-27 94.8 0.3 1.3 1 1 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI PF01399.22 ESL11638.1 - 0.02 15.1 0.9 0.04 14.2 0.1 1.8 2 0 0 2 2 2 0 PCI domain zf-CCCH PF00642.19 ESL11639.1 - 0.00012 21.6 7.3 0.034 13.8 0.6 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESL11639.1 - 1.5 8.9 5.5 8.2 6.6 0.7 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type tRNA-synt_1d PF00750.14 ESL11641.1 - 6.8e-87 291.5 0.1 1.1e-50 172.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.10 ESL11641.1 - 1.1e-24 86.6 1.2 3.6e-24 85.0 0.2 2.3 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 ESL11641.1 - 4.5e-12 46.3 0.0 1.5e-11 44.7 0.0 2.0 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain MTHFR PF02219.12 ESL11644.1 - 1.4e-05 24.3 0.0 0.059 12.4 0.0 2.6 3 0 0 3 3 3 2 Methylenetetrahydrofolate reductase PIG-L PF02585.12 ESL11646.1 - 3.8e-23 82.3 0.0 5.5e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF948 PF06103.6 ESL11647.1 - 0.039 13.7 0.0 0.15 11.9 0.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) WXG100 PF06013.7 ESL11647.1 - 0.047 13.6 0.5 0.12 12.4 0.3 1.7 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Mito_carr PF00153.22 ESL11648.1 - 1.1e-52 175.7 1.6 2.7e-20 71.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1632 PF07857.7 ESL11648.1 - 0.032 13.4 0.0 0.069 12.4 0.0 1.5 1 0 0 1 1 1 0 CEO family (DUF1632) Tctex-1 PF03645.8 ESL11649.1 - 1.5e-26 92.2 0.1 1.9e-26 91.8 0.1 1.2 1 0 0 1 1 1 1 Tctex-1 family FYVE PF01363.16 ESL11650.1 - 9.8e-05 22.1 13.9 0.0003 20.6 9.7 1.9 1 1 0 1 1 1 1 FYVE zinc finger Opy2 PF09463.5 ESL11650.1 - 0.018 15.1 2.3 0.018 15.1 1.6 2.5 2 0 0 2 2 2 0 Opy2 protein Fer2_3 PF13085.1 ESL11650.1 - 0.023 14.5 0.6 0.044 13.6 0.3 1.6 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain DUF2492 PF10678.4 ESL11650.1 - 0.078 13.0 1.1 0.57 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2492) zf-C2HC_2 PF13913.1 ESL11650.1 - 0.1 12.3 1.0 0.1 12.3 0.7 2.1 1 1 1 2 2 2 0 zinc-finger of a C2HC-type DUF4428 PF14471.1 ESL11650.1 - 0.46 10.2 4.0 3.4 7.4 2.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) zf-B_box PF00643.19 ESL11650.1 - 3.7 7.5 10.7 0.78 9.6 4.6 2.0 2 0 0 2 2 2 0 B-box zinc finger zf-C3HC4_2 PF13923.1 ESL11650.1 - 7.8 6.6 10.6 15 5.7 7.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Stm1_N PF09598.5 ESL11650.1 - 9.4 7.0 12.9 0.77 10.4 1.3 2.3 2 0 0 2 2 2 0 Stm1 Adenylsucc_synt PF00709.16 ESL11652.1 - 3.5e-110 368.5 0.0 4.3e-110 368.2 0.0 1.1 1 0 0 1 1 1 1 Adenylosuccinate synthetase Rap1_C PF11626.3 ESL11653.1 - 0.051 13.4 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Toxin_13 PF07822.6 ESL11653.1 - 0.085 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Neurotoxin B-IV-like protein LSM14 PF12701.2 ESL11654.1 - 2.5e-29 100.9 0.0 2.5e-29 100.9 0.0 1.7 2 0 0 2 2 2 1 Scd6-like Sm domain SM-ATX PF14438.1 ESL11654.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain FDF PF09532.5 ESL11654.1 - 0.033 14.7 3.1 0.033 14.7 2.1 3.2 2 1 1 3 3 3 0 FDF domain DUF4301 PF14134.1 ESL11654.1 - 0.04 12.4 0.6 0.055 12.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4301) Neur_chan_memb PF02932.11 ESL11654.1 - 0.088 12.6 1.7 0.13 12.1 1.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.17 ESL11654.1 - 0.34 9.8 4.5 0.57 9.1 3.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TRAPPC9-Trs120 PF08626.6 ESL11657.1 - 1.2e-10 39.4 0.0 0.0014 16.0 0.0 3.9 2 2 1 3 3 3 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit WD40 PF00400.27 ESL11658.1 - 2e-41 138.3 26.0 4e-06 26.4 0.1 11.0 11 0 0 11 11 11 9 WD domain, G-beta repeat PQQ_3 PF13570.1 ESL11658.1 - 0.0093 16.2 3.4 1.4e+02 2.9 0.0 5.8 4 1 1 5 5 5 0 PQQ-like domain Nucleoporin_N PF08801.6 ESL11658.1 - 0.036 12.7 1.1 0.22 10.2 0.0 2.7 4 0 0 4 4 4 0 Nup133 N terminal like Kelch_6 PF13964.1 ESL11658.1 - 0.038 14.1 1.7 30 4.9 0.1 4.3 4 0 0 4 4 4 0 Kelch motif Coatomer_WDAD PF04053.9 ESL11658.1 - 0.073 11.8 0.1 13 4.4 0.0 2.7 3 0 0 3 3 3 0 Coatomer WD associated region DUF72 PF01904.13 ESL11659.1 - 2e-43 148.8 0.7 1.8e-40 139.1 0.0 3.1 3 0 0 3 3 3 3 Protein of unknown function DUF72 Cyclin PF08613.6 ESL11661.1 - 4.7e-30 104.9 0.0 8.2e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 Cyclin RNA_pol_3_Rpc31 PF11705.3 ESL11661.1 - 0.19 11.6 3.8 0.41 10.5 2.7 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.8 ESL11661.1 - 4.2 7.1 7.5 1.8 8.3 0.2 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Rdx PF10262.4 ESL11662.1 - 5.6e-07 29.4 0.0 6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Rdx family RVP_2 PF08284.6 ESL11662.1 - 0.04 13.8 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease Galactosyl_T PF01762.16 ESL11663.1 - 8.3e-06 25.5 0.2 0.00036 20.1 0.0 2.4 2 1 0 3 3 3 2 Galactosyltransferase Kinesin PF00225.18 ESL11664.1 - 2.2e-101 338.8 0.2 2.2e-101 338.8 0.2 2.4 3 0 0 3 3 3 1 Kinesin motor domain AAA_22 PF13401.1 ESL11664.1 - 0.44 10.6 0.0 0.44 10.6 0.0 4.1 3 1 2 5 5 5 0 AAA domain Prefoldin_2 PF01920.15 ESL11665.1 - 2.8e-19 68.8 0.4 3.1e-19 68.6 0.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit DASH_Dad3 PF08656.5 ESL11665.1 - 0.0034 17.0 1.3 0.022 14.4 0.2 2.0 2 0 0 2 2 2 1 DASH complex subunit Dad3 SlyX PF04102.7 ESL11665.1 - 0.0037 17.5 1.0 0.056 13.8 0.0 2.2 2 0 0 2 2 2 1 SlyX Seryl_tRNA_N PF02403.17 ESL11665.1 - 0.021 14.8 0.3 0.03 14.3 0.2 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.9 ESL11665.1 - 0.045 13.3 3.3 0.47 10.0 0.8 2.0 1 1 1 2 2 2 0 IncA protein CENP-F_leu_zip PF10473.4 ESL11665.1 - 0.061 13.1 0.3 2.8 7.8 0.0 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 PF09787.4 ESL11665.1 - 0.062 11.8 0.1 0.068 11.6 0.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DASH_Spc34 PF08657.5 ESL11665.1 - 0.16 11.5 1.0 6.2 6.3 0.0 2.0 2 0 0 2 2 2 0 DASH complex subunit Spc34 Nup54 PF13874.1 ESL11665.1 - 0.24 11.0 1.6 9.5 5.8 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF4455 PF14643.1 ESL11665.1 - 0.24 9.9 1.5 0.54 8.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4455) DUF3847 PF12958.2 ESL11665.1 - 0.33 10.7 2.8 0.33 10.7 0.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) FliJ PF02050.11 ESL11665.1 - 0.49 10.4 4.0 6.2 6.8 0.3 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein Acyltransferase PF01553.16 ESL11666.1 - 0.0052 16.2 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase RRM_5 PF13893.1 ESL11667.1 - 2.7e-09 36.7 0.0 4e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESL11667.1 - 2.2e-08 33.5 0.0 4.3e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL11667.1 - 5.7e-08 32.6 0.0 7.7e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.7 ESL11667.1 - 0.0011 18.6 0.0 0.0013 18.3 0.0 1.1 1 0 0 1 1 1 1 Calcipressin Pkinase PF00069.20 ESL11668.1 - 2.5e-07 30.1 0.0 4.2e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESL11668.1 - 0.00064 19.5 0.1 0.0014 18.4 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESL11668.1 - 0.0024 17.0 0.0 0.0037 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 ESL11668.1 - 0.0092 15.5 0.1 0.015 14.9 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.1 ESL11668.1 - 0.021 13.8 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like IF-2B PF01008.12 ESL11669.1 - 2.1e-70 236.9 1.1 2.5e-70 236.6 0.8 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family SurE PF01975.12 ESL11669.1 - 0.025 13.9 1.3 4.8 6.4 0.3 2.4 2 0 0 2 2 2 0 Survival protein SurE Ribosomal_60s PF00428.14 ESL11669.1 - 1.4 9.3 5.0 0.77 10.1 0.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Arf PF00025.16 ESL11670.1 - 7.6e-65 217.3 0.0 8.6e-65 217.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESL11670.1 - 6.5e-15 54.7 0.6 2.5e-09 36.3 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 ESL11670.1 - 2.4e-11 43.2 0.0 2.8e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 ESL11670.1 - 5.9e-11 42.0 0.0 7.1e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ESL11670.1 - 1e-07 31.3 0.0 1.4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 ESL11670.1 - 2.3e-07 30.4 0.0 1.4e-06 27.8 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESL11670.1 - 2.5e-07 31.1 0.0 3.7e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESL11670.1 - 8.9e-07 28.8 0.0 1.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL11670.1 - 0.082 12.1 0.0 0.2 10.9 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.14 ESL11670.1 - 0.088 12.2 0.0 0.71 9.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SpoU_methylase PF00588.14 ESL11672.1 - 2.5e-18 66.3 0.0 6.5e-16 58.4 0.0 2.9 3 1 0 3 3 3 2 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 ESL11672.1 - 4.5e-06 26.7 0.0 0.0063 16.6 0.0 2.6 2 0 0 2 2 2 2 RNA 2'-O ribose methyltransferase substrate binding Histone PF00125.19 ESL11673.1 - 5.2e-15 55.3 0.4 7.2e-15 54.8 0.3 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESL11673.1 - 0.0067 16.4 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ART PF01129.13 ESL11674.1 - 0.15 11.1 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase UCH_1 PF13423.1 ESL11675.1 - 5.6e-26 91.6 0.0 1.9e-25 89.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 ESL11675.1 - 1.2e-20 74.4 0.0 8.7e-20 71.6 0.0 2.2 2 0 0 2 2 2 1 Exonuclease Cytochrom_D1 PF02239.11 ESL11675.1 - 0.13 10.5 0.2 0.2 9.8 0.1 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain zf-CW PF07496.10 ESL11676.1 - 9.7e-15 54.0 10.9 2.8e-09 36.5 4.5 3.7 3 0 0 3 3 3 2 CW-type Zinc Finger AAA_18 PF13238.1 ESL11676.1 - 4.3 7.6 6.8 0.5 10.6 0.6 2.5 3 0 0 3 3 3 0 AAA domain RRM_1 PF00076.17 ESL11677.1 - 7.4e-08 31.9 0.0 9.3e-08 31.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL11677.1 - 3.1e-06 27.0 0.0 4.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL11677.1 - 1e-05 25.2 0.0 1.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4586 PF15239.1 ESL11678.1 - 1.2e-75 254.9 9.4 1.4e-75 254.7 6.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) ubiquitin PF00240.18 ESL11679.1 - 4e-10 38.9 0.0 1.3e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family ubiquitin PF00240.18 ESL11681.1 - 0.00039 19.7 0.0 0.00072 18.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESL11681.1 - 0.00072 19.1 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HIT PF01230.18 ESL11684.1 - 1.1e-22 80.3 1.0 1.7e-22 79.8 0.7 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ESL11684.1 - 4.1e-14 52.7 0.0 6.4e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 ESL11684.1 - 1.9e-06 27.5 0.8 3.3e-06 26.7 0.4 1.5 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DSPc PF00782.15 ESL11685.1 - 1.1e-17 63.9 0.0 1.6e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain HSP70 PF00012.15 ESL11686.1 - 3.9e-40 137.3 0.1 3.9e-40 137.3 0.1 3.9 4 0 0 4 4 4 2 Hsp70 protein Spore_coat_CotO PF14153.1 ESL11686.1 - 0.68 9.3 6.5 1.2 8.5 4.5 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Nop14 PF04147.7 ESL11686.1 - 4.5 5.0 11.4 6.1 4.6 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESL11686.1 - 5.4 4.9 7.3 7.8 4.3 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 ESL11686.1 - 9.7 4.5 14.8 15 3.8 10.2 1.2 1 0 0 1 1 1 0 Daxx Family PAP_central PF04928.12 ESL11687.1 - 1.1e-82 276.6 0.0 1.5e-82 276.2 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 ESL11687.1 - 6.1e-24 84.3 0.0 1e-23 83.5 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 ESL11687.1 - 0.00065 19.9 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DNA_pol_B_palm PF14792.1 ESL11687.1 - 0.0055 16.7 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm MoeA_N PF03453.12 ESL11688.1 - 0.14 11.5 0.1 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 MoeA N-terminal region (domain I and II) RRM_1 PF00076.17 ESL11689.1 - 1.6e-73 242.3 0.0 3.3e-17 61.8 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL11689.1 - 7.2e-50 166.8 0.0 2.6e-12 46.5 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 ESL11689.1 - 3e-27 94.0 0.4 5.8e-27 93.1 0.3 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.1 ESL11689.1 - 4.2e-26 90.5 0.1 1e-06 28.4 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESL11689.1 - 1.5e-08 34.3 6.3 0.11 12.3 1.1 4.4 3 1 1 4 4 4 3 RNA binding motif Nup35_RRM_2 PF14605.1 ESL11689.1 - 1.2e-07 31.3 0.1 0.25 11.1 0.0 4.6 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 ESL11689.1 - 9.9e-07 28.4 0.0 0.14 11.9 0.0 4.4 3 1 1 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 ESL11689.1 - 4.6e-06 26.3 2.2 0.0027 17.4 0.0 3.8 4 1 0 4 4 4 2 Limkain b1 Peptidase_S49_N PF08496.5 ESL11689.1 - 0.13 12.0 1.2 0.25 11.1 0.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal LRR_6 PF13516.1 ESL11690.1 - 8.4e-05 22.2 0.2 0.31 11.2 0.1 3.6 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.28 ESL11690.1 - 0.00015 21.3 1.3 4.7 7.6 0.1 4.0 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_7 PF13504.1 ESL11690.1 - 0.0041 17.0 0.3 27 5.5 0.0 4.2 3 1 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.2 ESL11690.1 - 0.026 14.1 2.2 2.1 8.0 0.0 3.5 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) IFT57 PF10498.4 ESL11691.1 - 0.044 12.5 4.2 0.056 12.1 2.9 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Med4 PF10018.4 ESL11691.1 - 0.073 12.4 4.4 0.12 11.7 3.1 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Tox-ODYAM1 PF15642.1 ESL11691.1 - 0.099 11.2 2.3 0.12 11.0 1.6 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus DUF3552 PF12072.3 ESL11691.1 - 0.11 11.6 14.3 0.13 11.4 8.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) L_lactis_ph-MCP PF06673.6 ESL11691.1 - 0.25 10.0 3.2 0.39 9.4 2.2 1.3 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein OmpH PF03938.9 ESL11691.1 - 1 9.3 8.1 1.5 8.7 5.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RNF111_N PF15303.1 ESL11691.1 - 9.3 5.6 13.9 1e+02 2.2 9.7 1.9 1 1 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus Mnd1 PF03962.10 ESL11691.1 - 9.9 5.7 12.0 5.2 6.7 6.6 1.6 1 1 1 2 2 2 0 Mnd1 family PQQ_3 PF13570.1 ESL11692.1 - 0.021 15.1 5.5 0.14 12.4 0.2 3.4 3 1 0 3 3 3 0 PQQ-like domain WD40 PF00400.27 ESL11692.1 - 0.024 14.5 1.4 0.92 9.4 0.2 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF1177 PF06675.6 ESL11692.1 - 0.042 12.4 0.0 0.077 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1177) Glyco_hydro_38 PF01074.17 ESL11694.1 - 8.4e-65 218.7 5.3 1.3e-64 218.1 3.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 ESL11694.1 - 8.9e-41 140.1 0.0 1.2e-40 139.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 ESL11694.1 - 4e-20 71.7 0.0 9.9e-20 70.5 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase, middle domain RasGAP PF00616.14 ESL11695.1 - 5.9e-06 26.0 0.0 2.4e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Nol1_Nop2_Fmu PF01189.12 ESL11696.1 - 1.8e-20 73.4 0.1 9.3e-13 48.1 0.0 2.6 2 1 1 3 3 3 2 NOL1/NOP2/sun family Methyltransf_18 PF12847.2 ESL11696.1 - 0.00017 22.1 0.1 0.001 19.6 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL11696.1 - 0.00081 19.4 0.1 0.005 16.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11696.1 - 0.0021 17.6 0.0 0.0058 16.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 ESL11696.1 - 0.0031 16.5 0.0 0.0052 15.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.1 ESL11696.1 - 0.0063 16.8 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 ESL11696.1 - 0.072 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Lactamase_B_2 PF12706.2 ESL11697.1 - 2.7e-12 46.6 0.0 4.1e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESL11697.1 - 5.2e-07 29.5 0.0 7.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily He_PIG_assoc PF10632.4 ESL11697.1 - 0.00017 20.8 0.1 0.00048 19.3 0.0 1.8 1 0 0 1 1 1 1 He_PIG associated, NEW1 domain of bacterial glycohydrolase TPR_16 PF13432.1 ESL11698.1 - 4.6e-14 52.6 13.3 9.9e-06 26.0 1.2 6.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESL11698.1 - 8.4e-14 50.9 16.1 0.00021 20.8 0.2 6.0 4 2 2 6 6 6 4 TPR repeat TPR_19 PF14559.1 ESL11698.1 - 6.4e-13 48.8 1.2 0.00083 19.6 0.0 4.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11698.1 - 2.3e-10 40.1 14.0 0.0054 17.2 0.1 8.5 5 2 4 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11698.1 - 9.4e-10 37.6 14.9 0.99 9.4 0.1 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESL11698.1 - 2e-06 27.1 12.0 0.65 9.7 0.1 6.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL11698.1 - 9.6e-06 25.4 18.9 0.14 12.0 0.1 5.9 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESL11698.1 - 4.7e-05 23.2 0.2 0.06 13.5 0.0 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESL11698.1 - 8.1e-05 22.1 2.6 2.2 8.2 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL11698.1 - 0.003 17.6 5.3 0.16 12.1 0.3 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.4 ESL11698.1 - 0.0081 16.1 0.7 0.049 13.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESL11698.1 - 0.15 11.8 9.3 7.7 6.5 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL11698.1 - 0.96 10.0 8.2 11 6.7 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat OGFr_N PF04664.8 ESL11699.1 - 3.4e-08 33.0 0.5 6.1e-05 22.4 0.0 2.3 2 0 0 2 2 2 2 Opioid growth factor receptor (OGFr) conserved region EF-hand_8 PF13833.1 ESL11700.1 - 0.014 14.9 0.1 0.42 10.2 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair PB1 PF00564.19 ESL11701.1 - 0.099 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 PB1 domain DUF4208 PF13907.1 ESL11701.1 - 0.14 12.3 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Ribosomal_L7Ae PF01248.21 ESL11702.1 - 1.9e-24 84.9 0.0 2.3e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Radical_SAM PF04055.16 ESL11703.1 - 4.4e-15 56.2 0.0 1.2e-14 54.7 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 ESL11703.1 - 1.5e-07 31.2 0.3 2.5e-05 24.1 0.1 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family CNRIP1 PF15043.1 ESL11703.1 - 0.05 12.8 0.0 0.087 12.0 0.0 1.3 1 0 0 1 1 1 0 CB1 cannabinoid receptor-interacting protein 1 Mg296 PF09644.5 ESL11703.1 - 0.13 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Mg296 protein DUF3899 PF13038.1 ESL11704.1 - 6.5 6.9 8.7 1.9 8.6 1.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) Torsin PF06309.6 ESL11705.1 - 0.00012 21.9 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA PF00004.24 ESL11705.1 - 0.00014 22.0 0.0 0.00053 20.2 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 ESL11705.1 - 0.08 12.3 0.0 0.24 10.7 0.0 1.7 1 1 1 2 2 2 0 IstB-like ATP binding protein DUF1903 PF08991.5 ESL11706.1 - 0.11 12.7 0.7 0.16 12.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) Rpn3_C PF08375.6 ESL11706.1 - 0.11 12.9 0.2 0.19 12.1 0.1 1.4 1 0 0 1 1 1 0 Proteasome regulatory subunit C-terminal ArsA_ATPase PF02374.10 ESL11707.1 - 6.6e-93 311.0 0.0 8.8e-93 310.6 0.0 1.2 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 ESL11707.1 - 1.3e-12 47.5 0.6 1.6e-11 44.0 0.4 2.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.1 ESL11707.1 - 0.00017 21.0 0.2 0.00059 19.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_31 PF13614.1 ESL11707.1 - 0.00059 19.7 0.0 0.037 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 ESL11707.1 - 0.016 14.0 0.1 0.03 13.1 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.1 ESL11707.1 - 0.025 14.3 0.2 0.082 12.6 0.0 1.9 2 0 0 2 2 2 0 Part of AAA domain Fer4_NifH PF00142.13 ESL11707.1 - 0.057 12.5 0.0 0.17 11.0 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 ESL11707.1 - 0.07 12.5 0.1 5.3 6.4 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Ham1p_like PF01725.11 ESL11708.1 - 3.1e-55 186.4 0.0 3.5e-55 186.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF367 PF04034.8 ESL11710.1 - 7.4e-47 158.1 0.0 1e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 ESL11710.1 - 5.6e-10 38.6 0.0 1.2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Nucleoplasmin PF03066.10 ESL11710.1 - 0.29 10.6 9.3 0.4 10.1 6.5 1.2 1 0 0 1 1 1 0 Nucleoplasmin BSP_II PF05432.6 ESL11710.1 - 0.59 9.3 13.7 0.75 9.0 9.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Myc_N PF01056.13 ESL11710.1 - 3.4 6.7 8.2 4.7 6.2 5.7 1.3 1 0 0 1 1 1 0 Myc amino-terminal region Oxidored_FMN PF00724.15 ESL11712.1 - 6.5e-44 150.3 0.0 9.6e-44 149.7 0.0 1.3 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.9 ESL11712.1 - 5.4e-13 49.2 0.0 1.1e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESL11712.1 - 1.7e-09 37.5 0.0 9.4e-09 35.1 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESL11712.1 - 7.9e-09 34.8 0.0 7.3e-08 31.6 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESL11712.1 - 4.4e-08 33.4 0.1 0.0015 18.5 0.1 2.6 2 1 1 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESL11712.1 - 3.1e-07 30.6 0.1 0.00078 19.8 0.1 3.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ESL11712.1 - 3.5e-07 29.0 0.1 1.7e-06 26.7 0.0 2.1 1 1 1 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 ESL11712.1 - 6.7e-07 28.4 0.0 1.3e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 ESL11712.1 - 8.3e-07 28.4 0.0 1.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 ESL11712.1 - 0.00063 18.7 0.3 0.00093 18.1 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.19 ESL11712.1 - 0.001 18.2 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.12 ESL11712.1 - 0.0017 17.5 0.2 0.0044 16.1 0.0 1.7 2 0 0 2 2 2 1 Thi4 family FMO-like PF00743.14 ESL11712.1 - 0.0027 15.9 0.1 0.085 11.0 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like ApbA PF02558.11 ESL11712.1 - 0.0033 16.8 0.1 0.012 15.0 0.0 1.9 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 ESL11712.1 - 0.0044 16.6 0.0 0.022 14.4 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 ESL11712.1 - 0.011 15.7 0.8 0.14 12.1 0.1 2.9 3 0 0 3 3 3 0 NADH(P)-binding NAD_Gly3P_dh_N PF01210.18 ESL11712.1 - 0.014 15.1 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 ESL11712.1 - 0.019 13.9 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 ESL11712.1 - 0.026 14.2 0.0 0.072 12.8 0.0 1.8 1 0 0 1 1 1 0 FAD-NAD(P)-binding Shikimate_DH PF01488.15 ESL11712.1 - 0.049 13.7 0.0 13 5.9 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.9 ESL11712.1 - 0.05 12.9 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.1 ESL11712.1 - 0.061 13.5 0.0 1 9.6 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding ThiF PF00899.16 ESL11712.1 - 0.089 12.6 1.5 1.3 8.8 0.0 2.7 3 0 0 3 3 2 0 ThiF family Trp_halogenase PF04820.9 ESL11712.1 - 0.1 11.1 0.0 0.17 10.4 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase K_oxygenase PF13434.1 ESL11712.1 - 0.11 11.3 0.0 6.7 5.5 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) IncA PF04156.9 ESL11713.1 - 3.8 7.0 89.3 0.017 14.7 8.1 4.5 1 1 3 4 4 4 0 IncA protein Reo_sigmaC PF04582.7 ESL11713.1 - 9.2 5.3 18.2 1.6 7.8 0.5 3.8 1 1 3 4 4 4 0 Reovirus sigma C capsid protein DUF1891 PF09004.5 ESL11714.1 - 0.24 10.7 2.0 0.72 9.2 1.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1891) DUF87 PF01935.12 ESL11714.1 - 0.41 10.4 2.1 0.69 9.6 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 DS PF01916.12 ESL11715.1 - 3.1e-76 256.3 0.0 3.1e-75 253.0 0.0 1.9 1 1 0 1 1 1 1 Deoxyhypusine synthase PCI PF01399.22 ESL11716.1 - 0.0069 16.6 1.1 0.015 15.5 0.1 2.2 2 0 0 2 2 2 1 PCI domain DHO_dh PF01180.16 ESL11718.1 - 1.1e-69 234.6 0.0 1.3e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 ESL11718.1 - 0.0032 16.3 0.0 0.15 10.8 0.0 2.2 2 0 0 2 2 2 2 FMN-dependent dehydrogenase PcrB PF01884.12 ESL11718.1 - 0.021 14.1 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 PcrB family F_bP_aldolase PF01116.15 ESL11718.1 - 0.17 10.9 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Motile_Sperm PF00635.21 ESL11719.1 - 6.2e-08 32.2 0.0 1.4e-07 31.1 0.0 1.6 1 1 0 1 1 1 1 MSP (Major sperm protein) domain TPR_20 PF14561.1 ESL11720.1 - 3.9e-05 23.6 0.5 0.00037 20.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11720.1 - 5.9e-05 22.6 0.1 2.7 8.1 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL11720.1 - 0.002 17.9 0.4 0.02 14.8 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11720.1 - 0.018 15.3 1.5 1.9 8.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL11720.1 - 0.053 14.0 0.0 7.2 7.3 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESL11720.1 - 0.055 13.1 3.1 3.7 7.2 0.6 3.3 2 1 0 2 2 2 0 TPR repeat TPR_1 PF00515.23 ESL11720.1 - 0.082 12.5 1.2 9.8 5.9 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESL11720.1 - 0.11 13.2 4.7 24 5.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Myb_DNA-bind_3 PF12776.2 ESL11720.1 - 0.16 12.5 0.5 0.4 11.3 0.4 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain TPR_14 PF13428.1 ESL11720.1 - 0.57 10.9 3.1 66 4.5 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4398 PF14346.1 ESL11720.1 - 3.6 7.6 7.2 5.1 7.2 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) DUF4588 PF15251.1 ESL11722.1 - 0.03 14.2 1.2 1.2 9.0 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4588) CD20 PF04103.10 ESL11723.1 - 0.056 13.3 0.1 0.056 13.3 0.1 3.4 4 1 0 4 4 4 0 CD20-like family DUF2953 PF11167.3 ESL11723.1 - 0.66 9.9 2.8 14 5.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2953) AAA_6 PF12774.2 ESL11724.1 - 6.2e-85 284.3 0.0 3.1e-83 278.8 0.0 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 ESL11724.1 - 9.9e-36 122.5 0.2 2.6e-21 75.8 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_8 PF12780.2 ESL11724.1 - 5.9e-31 107.4 0.1 1.3e-28 99.7 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 MT PF12777.2 ESL11724.1 - 1.4e-25 89.7 10.7 2.1e-25 89.1 7.4 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESL11724.1 - 2.5e-22 79.2 0.2 3.5e-21 75.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_16 PF13191.1 ESL11724.1 - 3.2e-14 53.3 3.7 0.00032 20.7 0.0 5.6 5 1 1 6 6 5 3 AAA ATPase domain AAA PF00004.24 ESL11724.1 - 5.1e-12 46.1 0.9 0.019 15.1 0.0 4.7 5 1 0 5 5 4 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESL11724.1 - 8e-11 42.1 0.9 0.005 16.9 0.0 4.4 4 0 0 4 4 3 3 AAA domain AAA_17 PF13207.1 ESL11724.1 - 3.2e-09 37.6 0.0 0.00047 20.9 0.0 4.6 5 0 0 5 5 3 1 AAA domain RNA_helicase PF00910.17 ESL11724.1 - 3.6e-07 30.3 0.1 1.9 8.7 0.0 4.2 4 0 0 4 4 3 1 RNA helicase AAA_33 PF13671.1 ESL11724.1 - 1.1e-06 28.6 1.8 0.008 16.0 0.0 4.1 5 0 0 5 5 3 1 AAA domain AAA_28 PF13521.1 ESL11724.1 - 1.3e-06 28.4 4.5 0.088 12.7 0.0 4.8 5 0 0 5 5 3 2 AAA domain AAA_19 PF13245.1 ESL11724.1 - 1.4e-06 27.9 0.4 0.15 11.8 0.0 3.6 3 0 0 3 3 3 1 Part of AAA domain AAA_14 PF13173.1 ESL11724.1 - 1.6e-06 28.0 0.0 0.073 12.9 0.0 4.0 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 ESL11724.1 - 6.3e-06 25.4 0.0 0.0033 16.6 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function, DUF258 NACHT PF05729.7 ESL11724.1 - 7e-06 25.8 0.6 0.095 12.3 0.0 3.5 3 0 0 3 3 3 2 NACHT domain ABC_tran PF00005.22 ESL11724.1 - 3.7e-05 24.0 6.9 0.0065 16.7 0.0 3.9 4 0 0 4 4 3 1 ABC transporter Arch_ATPase PF01637.13 ESL11724.1 - 5.7e-05 22.9 9.9 0.14 11.7 0.0 4.8 5 0 0 5 5 5 2 Archaeal ATPase UPF0079 PF02367.12 ESL11724.1 - 6.3e-05 22.5 0.1 0.18 11.4 0.0 3.6 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 AAA_25 PF13481.1 ESL11724.1 - 6.5e-05 22.4 0.0 0.095 12.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 ESL11724.1 - 9.6e-05 21.5 2.7 0.092 11.8 0.0 3.9 4 0 0 4 4 3 1 Zeta toxin AAA_30 PF13604.1 ESL11724.1 - 9.7e-05 22.0 4.7 0.028 13.9 0.0 3.5 4 0 0 4 4 3 2 AAA domain Sigma54_activ_2 PF14532.1 ESL11724.1 - 0.00057 19.9 0.0 1.4 8.9 0.0 3.8 4 0 0 4 4 3 1 Sigma-54 interaction domain AAA_23 PF13476.1 ESL11724.1 - 0.00065 20.0 17.6 4.9 7.4 0.0 4.6 5 0 0 5 5 4 0 AAA domain IstB_IS21 PF01695.12 ESL11724.1 - 0.00073 18.9 0.1 1 8.7 0.0 3.6 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_18 PF13238.1 ESL11724.1 - 0.00087 19.5 8.9 0.031 14.5 0.0 5.2 6 0 0 6 6 4 1 AAA domain MobB PF03205.9 ESL11724.1 - 0.00092 18.9 2.1 0.092 12.4 0.0 4.0 4 0 0 4 4 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_PrkA PF08298.6 ESL11724.1 - 0.00092 17.9 0.0 0.042 12.5 0.0 2.5 2 0 0 2 2 2 1 PrkA AAA domain AAA_29 PF13555.1 ESL11724.1 - 0.0012 18.2 0.1 0.063 12.8 0.0 3.2 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_24 PF13479.1 ESL11724.1 - 0.0018 17.9 0.2 13 5.2 0.0 3.8 3 0 0 3 3 3 0 AAA domain SRPRB PF09439.5 ESL11724.1 - 0.0023 17.1 4.4 0.18 11.0 0.0 3.6 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit T2SE PF00437.15 ESL11724.1 - 0.0026 16.6 0.6 0.14 11.0 0.0 3.2 4 0 0 4 4 3 1 Type II/IV secretion system protein NB-ARC PF00931.17 ESL11724.1 - 0.0034 16.2 0.1 0.11 11.3 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain DAP3 PF10236.4 ESL11724.1 - 0.0047 15.9 0.2 1.6 7.6 0.0 2.6 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 DUF815 PF05673.8 ESL11724.1 - 0.0063 15.4 0.3 3.8 6.3 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF815) cobW PF02492.14 ESL11724.1 - 0.0064 15.9 1.1 3 7.2 0.1 3.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.16 ESL11724.1 - 0.0068 15.5 2.1 1.3 8.1 0.0 3.1 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI DUF4559 PF15112.1 ESL11724.1 - 0.0071 15.5 7.4 0.024 13.7 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4559) AAA_21 PF13304.1 ESL11724.1 - 0.0077 16.2 0.0 0.025 14.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ESL11724.1 - 0.02 14.3 0.6 4 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain DUF4497 PF14924.1 ESL11724.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) ATG16 PF08614.6 ESL11724.1 - 0.035 13.9 14.5 0.24 11.2 0.8 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Viral_helicase1 PF01443.13 ESL11724.1 - 0.037 13.5 0.5 5.7 6.3 0.0 3.0 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase CbiA PF01656.18 ESL11724.1 - 0.049 13.0 2.0 8.2 5.7 0.0 4.3 5 0 0 5 5 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_13 PF13166.1 ESL11724.1 - 0.1 11.0 13.8 0.25 9.7 4.1 3.0 3 0 0 3 3 3 0 AAA domain V_ATPase_I PF01496.14 ESL11724.1 - 0.15 9.9 14.8 0.32 8.8 10.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_GPO PF05929.6 ESL11724.1 - 0.21 10.8 12.2 0.17 11.1 4.3 2.3 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Laminin_I PF06008.9 ESL11724.1 - 0.22 10.8 18.2 0.82 8.9 5.9 2.4 2 0 0 2 2 2 0 Laminin Domain I ATP_bind_1 PF03029.12 ESL11724.1 - 0.39 10.2 4.2 5.1 6.5 0.0 3.5 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein Laminin_II PF06009.7 ESL11724.1 - 0.4 10.4 16.0 0.6 9.8 0.6 2.8 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.6 ESL11724.1 - 0.41 9.2 18.6 0.29 9.7 6.4 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein Guanylate_kin PF00625.16 ESL11724.1 - 0.47 9.8 10.5 1.1 8.7 0.0 3.7 4 0 0 4 4 3 0 Guanylate kinase Reo_sigmaC PF04582.7 ESL11724.1 - 0.66 9.0 3.4 1.2 8.1 0.3 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein GRA6 PF05084.8 ESL11724.1 - 1.8 8.0 4.5 3.6 7.0 3.1 1.4 1 0 0 1 1 1 0 Granule antigen protein (GRA6) IncA PF04156.9 ESL11724.1 - 1.8 8.0 22.7 1 8.9 2.3 3.1 3 0 0 3 3 2 0 IncA protein APG6 PF04111.7 ESL11724.1 - 2.7 6.9 19.8 1.7 7.6 1.8 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 MAD PF05557.8 ESL11724.1 - 3.7 5.5 22.1 2.9 5.8 7.6 2.3 2 0 0 2 2 2 0 Mitotic checkpoint protein G-alpha PF00503.15 ESL11724.1 - 4.5 5.8 9.4 0.18 10.4 0.0 2.4 2 0 0 2 2 1 0 G-protein alpha subunit L31 PF09784.4 ESL11724.1 - 5.1 7.2 9.6 48 4.0 2.7 3.3 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L31 TPR_MLP1_2 PF07926.7 ESL11724.1 - 6 6.6 20.7 3.8 7.2 1.0 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 ESL11724.1 - 8.8 5.1 20.8 4.3 6.2 6.3 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Fib_alpha PF08702.5 ESL11724.1 - 8.8 6.4 19.4 0.51 10.4 5.3 3.2 3 0 0 3 3 2 0 Fibrinogen alpha/beta chain family EF-hand_8 PF13833.1 ESL11726.1 - 2.4e-09 36.6 0.2 0.0019 17.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 ESL11726.1 - 1.4e-06 28.3 3.5 0.0027 17.7 0.2 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL11726.1 - 4.9e-06 25.4 1.1 0.079 12.2 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESL11726.1 - 0.00037 20.1 1.3 2.5 8.2 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain HAD_2 PF13419.1 ESL11726.1 - 0.03 14.5 0.5 0.043 14.0 0.3 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase zf-rbx1 PF12678.2 ESL11727.1 - 2.9e-32 110.5 11.5 3.7e-32 110.2 8.0 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESL11727.1 - 2.6e-16 59.2 8.8 3.5e-16 58.8 6.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 ESL11727.1 - 1.4e-06 27.9 13.6 1.1e-05 25.1 9.4 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESL11727.1 - 0.00039 20.0 9.4 0.084 12.5 7.0 2.3 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESL11727.1 - 0.0006 19.4 11.3 0.0061 16.1 7.9 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) VSP PF03302.8 ESL11727.1 - 0.013 14.1 1.1 0.015 13.9 0.7 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein zf-C3HC4_2 PF13923.1 ESL11727.1 - 0.045 13.7 12.4 1.1 9.3 8.6 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 ESL11727.1 - 0.093 12.7 8.6 0.19 11.7 5.8 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.3 ESL11727.1 - 0.13 11.8 2.6 0.21 11.1 1.8 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-HC5HC2H_2 PF13832.1 ESL11727.1 - 0.23 11.4 9.7 0.53 10.2 6.7 1.7 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_5 PF14634.1 ESL11727.1 - 0.29 10.8 12.0 4.9 6.9 8.4 2.4 1 1 0 1 1 1 0 zinc-RING finger domain zf-HC5HC2H PF13771.1 ESL11727.1 - 0.86 9.7 10.5 56 3.9 7.3 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain LRR_4 PF12799.2 ESL11728.1 - 6.3e-15 54.4 14.2 0.02 14.5 0.0 8.1 5 4 4 9 9 9 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL11728.1 - 8e-06 25.5 14.1 0.93 9.3 0.0 5.9 5 2 1 6 6 6 3 Leucine rich repeat LRR_6 PF13516.1 ESL11728.1 - 0.5 10.5 21.5 32 5.0 0.2 9.3 10 1 1 11 11 11 0 Leucine Rich repeat LRR_7 PF13504.1 ESL11728.1 - 0.62 10.4 22.2 26 5.6 0.0 8.7 11 1 0 11 11 11 0 Leucine rich repeat Gate PF07670.9 ESL11729.1 - 0.095 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Nucleoside recognition Glutaredoxin PF00462.19 ESL11730.1 - 3.9e-16 58.7 0.0 7.9e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin SH3BGR PF04908.10 ESL11730.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DUF1935 PF09149.5 ESL11731.1 - 7.3e-25 86.9 0.0 1e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Pkinase PF00069.20 ESL11732.1 - 3.1e-48 164.2 0.0 4.6e-48 163.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11732.1 - 7.8e-17 61.1 0.0 1.3e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL11732.1 - 3.3e-05 23.7 0.0 0.00018 21.3 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family PIP49_C PF12260.3 ESL11732.1 - 0.00071 19.0 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Choline_kinase PF01633.15 ESL11732.1 - 0.0024 17.5 0.0 0.0041 16.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.6 ESL11732.1 - 0.059 12.1 0.2 0.088 11.5 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase GST_N_3 PF13417.1 ESL11733.1 - 8.7e-35 118.7 0.0 5e-16 58.6 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESL11733.1 - 1.3e-25 89.2 0.1 1e-11 44.6 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESL11733.1 - 1.7e-15 56.8 0.0 1.8e-08 34.4 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESL11733.1 - 3.9e-13 49.0 1.6 2.3e-07 30.5 0.0 2.8 3 0 0 3 3 3 2 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.19 ESL11733.1 - 5.3e-09 35.9 0.2 4.7e-06 26.4 0.1 2.5 2 0 0 2 2 2 2 Glutaredoxin GST_C_3 PF14497.1 ESL11733.1 - 1.8e-07 31.5 0.0 0.00044 20.6 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ESL11733.1 - 4.3e-06 26.6 0.2 0.12 12.3 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain Tom37 PF10568.4 ESL11733.1 - 0.068 13.4 0.0 8.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein NUDIX PF00293.23 ESL11734.1 - 2.3e-12 46.7 0.0 3.3e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Thioredoxin PF00085.15 ESL11735.1 - 4.3e-15 55.2 0.0 2.4e-14 52.8 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 ESL11735.1 - 0.00019 21.6 0.0 0.0031 17.6 0.0 2.7 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESL11735.1 - 0.00026 20.9 0.2 0.018 15.0 0.0 3.2 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_8 PF13905.1 ESL11735.1 - 0.0087 16.1 0.0 0.42 10.7 0.0 3.0 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_6 PF13848.1 ESL11735.1 - 0.17 11.6 0.0 3.1 7.5 0.0 2.5 2 1 0 2 2 2 0 Thioredoxin-like domain Methyltransf_28 PF02636.12 ESL11736.1 - 7.5e-37 127.0 0.0 1e-36 126.6 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.15 ESL11736.1 - 2.2e-05 23.5 0.0 3.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.2 ESL11736.1 - 0.00083 19.9 0.0 0.0015 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 ESL11736.1 - 0.0023 16.9 0.0 0.0035 16.3 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_26 PF13659.1 ESL11736.1 - 0.0023 17.9 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11736.1 - 0.0026 17.3 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESL11736.1 - 0.016 15.6 0.0 0.028 14.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 ESL11736.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DAGK_cat PF00781.19 ESL11737.1 - 4e-14 52.1 0.0 6.2e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.16 ESL11737.1 - 0.00055 18.7 0.0 0.00078 18.2 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase PFK PF00365.15 ESL11737.1 - 0.042 12.7 0.1 0.11 11.4 0.0 1.6 2 0 0 2 2 2 0 Phosphofructokinase PS_pyruv_trans PF04230.8 ESL11737.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase RNase_P_pop3 PF08228.6 ESL11737.1 - 0.082 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 RNase P subunit Pop3 TP_methylase PF00590.15 ESL11737.1 - 0.096 12.3 0.1 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases GATase PF00117.23 ESL11737.1 - 0.15 11.5 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I AMP-binding PF00501.23 ESL11739.1 - 2.8e-36 124.8 0.0 4e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Glutaredoxin PF00462.19 ESL11740.1 - 1e-09 38.2 0.9 2.7e-09 36.8 0.5 1.8 1 1 1 2 2 2 1 Glutaredoxin GST_N_3 PF13417.1 ESL11740.1 - 2.6e-08 33.9 0.0 5e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESL11740.1 - 9.8e-06 25.9 0.0 1.7e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Prok-RING_4 PF14447.1 ESL11740.1 - 0.094 12.2 0.2 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 GlnE PF03710.10 ESL11741.1 - 0.044 13.0 0.6 0.05 12.8 0.4 1.1 1 0 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase IF4E PF01652.13 ESL11742.1 - 3.5e-30 104.6 0.0 5.2e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E dCMP_cyt_deam_1 PF00383.17 ESL11743.1 - 0.0039 16.8 0.9 0.021 14.4 0.6 2.2 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region SET PF00856.23 ESL11744.1 - 3.1e-09 37.3 0.0 5.6e-08 33.2 0.0 2.2 2 0 0 2 2 2 1 SET domain PNPase_C PF12111.3 ESL11744.1 - 1.3 8.2 4.2 4.5 6.5 0.1 2.5 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal Proteasome PF00227.21 ESL11745.1 - 2.7e-29 101.8 0.1 3.3e-29 101.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Glycos_transf_1 PF00534.15 ESL11746.1 - 1.2e-24 86.6 0.0 1.7e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESL11746.1 - 7.4e-13 48.8 0.0 1.3e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESL11746.1 - 0.00062 19.9 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF1689 PF07954.6 ESL11746.1 - 0.0081 16.0 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) Prenyltrans PF00432.16 ESL11747.1 - 1.9e-64 212.8 18.4 2e-13 49.6 0.0 5.7 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESL11747.1 - 3.1e-44 149.9 3.2 7.8e-19 68.1 0.0 3.4 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESL11747.1 - 9.5e-16 57.7 0.5 3.3e-06 27.0 0.0 4.0 1 1 3 4 4 4 3 Prenyltransferase-like A2M_comp PF07678.9 ESL11747.1 - 0.047 12.9 1.1 30 3.7 0.0 3.7 2 1 3 5 5 5 0 A-macroglobulin complement component VPS11_C PF12451.3 ESL11747.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal DnaJ PF00226.26 ESL11748.1 - 0.0049 16.5 0.0 0.0085 15.8 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DAGAT PF03982.8 ESL11749.1 - 1.4e-78 263.6 0.0 1.6e-78 263.4 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Peptidase_C54 PF03416.14 ESL11750.1 - 3.6e-52 177.2 0.0 5.2e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 Oligomerisation PF02410.10 ESL11751.1 - 5.1e-16 58.5 0.8 9e-16 57.7 0.5 1.4 1 0 0 1 1 1 1 Oligomerisation domain DUF2939 PF11159.3 ESL11752.1 - 0.067 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) HRDC PF00570.18 ESL11752.1 - 0.1 12.3 0.2 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 HRDC domain KH_4 PF13083.1 ESL11752.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 KH domain Acetyltransf_1 PF00583.19 ESL11755.1 - 4e-13 49.1 0.0 5.8e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESL11755.1 - 1.5e-10 41.0 0.0 2.2e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESL11755.1 - 9.2e-06 25.5 0.0 1.6e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESL11755.1 - 2.9e-05 24.1 0.0 4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESL11755.1 - 0.00023 21.1 0.0 0.00031 20.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESL11755.1 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_13 PF13880.1 ESL11755.1 - 0.012 15.2 0.0 0.032 13.9 0.0 1.7 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase CHAP PF05257.11 ESL11756.1 - 2.6e-21 75.5 0.2 8.5e-21 73.8 0.0 1.7 1 1 1 2 2 2 1 CHAP domain Amidase_6 PF12671.2 ESL11756.1 - 0.0038 17.2 0.0 0.0066 16.5 0.0 1.5 1 1 0 1 1 1 1 Putative amidase domain FA_desaturase PF00487.19 ESL11757.1 - 1.8e-36 125.9 20.3 2.6e-36 125.3 14.0 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 ESL11757.1 - 1.8e-06 27.6 0.1 3.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rer1 PF03248.8 ESL11757.1 - 0.00019 21.0 0.2 0.00036 20.1 0.1 1.4 1 0 0 1 1 1 1 Rer1 family FHA PF00498.21 ESL11758.1 - 8.3e-05 22.6 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 FHA domain HMG_CoA_synt_C PF08540.5 ESL11759.1 - 0.23 10.8 3.4 0.15 11.5 0.8 1.7 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal PCIF1_WW PF12237.3 ESL11760.1 - 2e-37 128.1 0.2 1.6e-36 125.2 0.1 2.1 2 0 0 2 2 2 1 Phosphorylated CTD interacting factor 1 WW domain Methuselah_N PF06652.7 ESL11760.1 - 0.081 12.4 0.2 0.33 10.4 0.1 1.9 2 0 0 2 2 2 0 Methuselah N-terminus Macro PF01661.16 ESL11762.1 - 0.0063 16.4 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 Macro domain EF-hand_7 PF13499.1 ESL11764.1 - 3.8e-15 55.7 0.1 8.6e-12 45.0 0.0 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESL11764.1 - 4e-08 32.4 0.2 0.00047 19.8 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESL11764.1 - 3.9e-07 28.9 0.3 0.0025 16.9 0.0 3.2 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 ESL11764.1 - 2.5e-05 23.3 0.8 0.00024 20.3 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.1 ESL11764.1 - 0.011 15.3 0.1 11 5.6 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain pair SPARC_Ca_bdg PF10591.4 ESL11764.1 - 0.054 13.5 0.1 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DNA_pol_B_palm PF14792.1 ESL11765.1 - 2.9e-20 72.4 0.0 6e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 ESL11765.1 - 7.7e-19 67.1 0.0 2.9e-11 42.8 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 ESL11765.1 - 1.2e-15 56.8 0.0 5.1e-15 54.7 0.0 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 ESL11765.1 - 1.1e-14 54.3 0.2 8.8e-13 48.2 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.1 ESL11765.1 - 0.00045 20.3 0.0 0.47 10.6 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix domain IMS_HHH PF11798.3 ESL11765.1 - 0.017 15.1 0.0 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 IMS family HHH motif RNA_pol_A_CTD PF03118.10 ESL11765.1 - 0.025 13.9 0.1 8.5 5.8 0.0 2.9 2 1 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain HHH_3 PF12836.2 ESL11765.1 - 0.099 12.5 0.1 5.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif Enkurin PF13864.1 ESL11766.1 - 1.3e-23 83.0 8.5 2.2e-23 82.3 5.9 1.4 1 0 0 1 1 1 1 Calmodulin-binding HAUS5 PF14817.1 ESL11766.1 - 0.016 13.8 2.1 0.021 13.4 1.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 AMPKBI PF04739.10 ESL11767.1 - 2.5e-18 65.8 0.0 4.1e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain SURF1 PF02104.10 ESL11768.1 - 2.4e-26 92.8 1.1 3.6e-26 92.3 0.0 1.7 2 0 0 2 2 2 1 SURF1 family Kinesin PF00225.18 ESL11769.1 - 2.5e-82 276.2 0.0 3.8e-82 275.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain CENP-B_N PF04218.8 ESL11769.1 - 0.12 11.8 0.1 0.27 10.6 0.1 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Mito_fiss_reg PF05308.6 ESL11769.1 - 1.8 7.8 11.0 2.5 7.3 6.1 2.4 2 1 0 2 2 2 0 Mitochondrial fission regulator Ribosomal_L23 PF00276.15 ESL11770.1 - 2.5e-05 24.1 0.1 3.9e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 Ribosomal_L27 PF01016.14 ESL11771.1 - 0.071 12.8 0.2 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Ribosomal L27 protein DnaJ PF00226.26 ESL11773.1 - 1.2e-27 95.4 3.3 2.4e-27 94.4 2.3 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESL11773.1 - 3.9e-22 77.9 0.1 3.7e-16 58.7 0.0 3.4 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESL11773.1 - 8.1e-14 51.4 13.7 1.4e-13 50.6 9.5 1.4 1 0 0 1 1 1 1 DnaJ central domain DZR PF12773.2 ESL11773.1 - 3.3 7.5 7.7 18 5.2 0.9 2.6 2 0 0 2 2 2 0 Double zinc ribbon HypA PF01155.14 ESL11773.1 - 7.5 6.2 10.3 0.98 9.1 1.5 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family 2-oxoacid_dh PF00198.18 ESL11774.1 - 2.3e-72 242.9 0.0 3.6e-72 242.3 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.12 ESL11774.1 - 5.3e-14 51.5 2.4 5.8e-12 45.0 0.8 2.8 2 0 0 2 2 2 2 e3 binding domain Biotin_lipoyl PF00364.17 ESL11774.1 - 3e-11 42.8 0.1 6e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme DEAD PF00270.24 ESL11774.1 - 0.00015 21.3 0.1 0.057 12.9 0.1 2.4 2 1 0 2 2 2 2 DEAD/DEAH box helicase Pex24p PF06398.6 ESL11775.1 - 1.9 7.2 9.2 3.3 6.3 6.4 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DnaJ PF00226.26 ESL11776.1 - 5.1e-17 61.3 1.9 1e-16 60.4 1.3 1.5 1 0 0 1 1 1 1 DnaJ domain Metal_resist PF13801.1 ESL11776.1 - 0.003 17.5 0.3 0.0065 16.4 0.2 1.5 1 0 0 1 1 1 1 Heavy-metal resistance ResIII PF04851.10 ESL11778.1 - 2.2e-13 50.4 0.0 4.3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T5orf172 PF10544.4 ESL11778.1 - 2.3e-07 31.1 0.0 6.6e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 T5orf172 domain DEAD PF00270.24 ESL11778.1 - 3.2e-06 26.7 0.0 5.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL11778.1 - 0.0059 16.4 0.0 0.024 14.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain MUG113 PF13455.1 ESL11778.1 - 0.0061 16.9 0.0 0.024 15.1 0.0 2.1 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 RecR PF02132.10 ESL11778.1 - 0.07 12.5 0.1 0.07 12.5 0.1 2.5 3 0 0 3 3 3 0 RecR protein DUF4567 PF15131.1 ESL11778.1 - 0.16 12.0 0.0 0.48 10.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4567) DUF3505 PF12013.3 ESL11778.1 - 0.27 11.4 4.7 0.29 11.3 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3505) TGT PF01702.13 ESL11779.1 - 6.6e-90 300.5 0.0 9e-90 300.1 0.0 1.2 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Herpes_UL56 PF04534.7 ESL11780.1 - 0.0088 15.7 3.0 0.045 13.4 2.1 1.9 1 1 0 1 1 1 1 Herpesvirus UL56 protein CAF-1_p150 PF11600.3 ESL11781.1 - 0.002 17.5 12.2 0.002 17.5 8.5 2.4 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal p31comet PF06581.7 ESL11781.1 - 0.019 13.8 1.3 0.038 12.8 0.9 1.4 1 0 0 1 1 1 0 Mad1 and Cdc20-bound-Mad2 binding HhH-GPD PF00730.20 ESL11781.1 - 0.047 13.9 0.3 0.16 12.2 0.2 2.0 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein CorA PF01544.13 ESL11781.1 - 3.6 6.5 6.7 9.5 5.1 4.6 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein TPR_7 PF13176.1 ESL11781.1 - 8.5 6.4 8.7 6.1 6.9 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA PF00004.24 ESL11783.1 - 1.6e-46 157.7 0.0 3.6e-46 156.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESL11783.1 - 1.1e-08 34.8 0.0 3e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESL11783.1 - 4.5e-07 30.0 0.1 2e-05 24.6 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 ESL11783.1 - 8.4e-07 29.0 0.1 2.2e-06 27.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESL11783.1 - 2.2e-06 27.8 0.4 7.8e-05 22.8 0.3 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL11783.1 - 7.9e-05 21.8 0.0 0.00019 20.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESL11783.1 - 0.00011 22.1 0.0 0.00039 20.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESL11783.1 - 0.00011 22.9 0.0 0.00021 22.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL11783.1 - 0.00033 20.3 0.0 0.0011 18.6 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain NTPase_1 PF03266.10 ESL11783.1 - 0.00051 19.7 0.1 0.0032 17.2 0.0 2.2 2 0 0 2 2 2 1 NTPase DUF815 PF05673.8 ESL11783.1 - 0.00053 18.9 0.0 0.00091 18.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 ESL11783.1 - 0.00066 19.6 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESL11783.1 - 0.00081 19.0 0.3 0.029 14.0 0.0 3.0 2 1 1 3 3 3 1 NACHT domain AAA_25 PF13481.1 ESL11783.1 - 0.0023 17.3 3.1 0.049 13.0 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.1 ESL11783.1 - 0.0028 17.5 0.0 0.0061 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESL11783.1 - 0.004 16.7 0.0 0.0095 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESL11783.1 - 0.0052 15.9 0.0 0.014 14.5 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 ESL11783.1 - 0.006 15.6 0.0 0.013 14.5 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Arch_ATPase PF01637.13 ESL11783.1 - 0.0064 16.2 0.1 0.071 12.7 0.0 2.1 1 1 1 2 2 2 1 Archaeal ATPase RNA_helicase PF00910.17 ESL11783.1 - 0.0079 16.3 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.8 ESL11783.1 - 0.0092 14.7 0.1 0.019 13.7 0.1 1.5 1 1 0 1 1 1 1 TIP49 C-terminus Sigma54_activat PF00158.21 ESL11783.1 - 0.01 15.3 0.0 0.47 9.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Bac_DnaA PF00308.13 ESL11783.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_18 PF13238.1 ESL11783.1 - 0.015 15.6 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESL11783.1 - 0.015 14.6 0.0 0.031 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.6 ESL11783.1 - 0.016 14.8 0.0 0.068 12.7 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 ESL11783.1 - 0.016 14.3 1.1 0.86 8.6 0.0 2.9 2 1 1 3 3 3 0 KaiC AAA_30 PF13604.1 ESL11783.1 - 0.02 14.4 0.0 0.058 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 ESL11783.1 - 0.022 14.4 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AFG1_ATPase PF03969.11 ESL11783.1 - 0.034 12.9 0.1 0.33 9.7 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase AAA_11 PF13086.1 ESL11783.1 - 0.049 13.2 0.2 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 ESL11783.1 - 0.058 12.2 0.0 0.19 10.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.22 ESL11783.1 - 0.087 13.1 0.1 0.27 11.5 0.0 2.1 2 1 0 2 2 1 0 ABC transporter Guanylate_kin PF00625.16 ESL11783.1 - 0.2 11.1 1.7 0.64 9.4 0.0 2.5 2 1 2 4 4 4 0 Guanylate kinase DUF465 PF04325.8 ESL11783.1 - 1.4 8.6 4.3 2.9 7.6 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF465) MIP PF00230.15 ESL11784.1 - 1.9e-35 122.4 26.4 2.2e-30 105.8 12.0 1.4 1 1 1 2 2 2 2 Major intrinsic protein Bax1-I PF01027.15 ESL11784.1 - 2.4 7.6 21.0 0.74 9.3 8.2 2.6 1 1 2 3 3 3 0 Inhibitor of apoptosis-promoting Bax1 Aldedh PF00171.17 ESL11785.1 - 1e-14 53.7 3.5 3.1e-10 39.0 2.0 2.7 2 1 0 2 2 2 2 Aldehyde dehydrogenase family PrpR_N PF06506.6 ESL11785.1 - 0.00052 19.4 0.2 0.0017 17.7 0.2 1.8 1 1 0 1 1 1 1 Propionate catabolism activator Myosin_tail_1 PF01576.14 ESL11786.1 - 0.077 10.7 46.0 0.063 11.0 20.4 2.1 1 1 1 2 2 2 0 Myosin tail LXG PF04740.7 ESL11786.1 - 4.8 6.9 9.2 0.14 11.9 0.2 2.7 3 1 0 3 3 3 0 LXG domain of WXG superfamily UQ_con PF00179.21 ESL11787.1 - 4.6e-34 116.8 0.1 5.9e-34 116.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ras PF00071.17 ESL11788.1 - 3.4e-54 182.6 0.0 4e-54 182.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL11788.1 - 1.5e-16 60.9 0.0 3.9e-16 59.6 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESL11788.1 - 4.1e-10 39.1 0.0 5.1e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESL11788.1 - 1.1e-06 28.2 0.0 2.4e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL11788.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESL11788.1 - 2.5e-05 23.5 0.1 3.3e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.1 ESL11788.1 - 0.00044 20.3 0.0 0.0011 18.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 ESL11788.1 - 0.0005 20.3 0.0 0.0014 18.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 ESL11788.1 - 0.0016 17.9 0.0 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.11 ESL11788.1 - 0.0019 17.3 0.0 0.0088 15.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRPRB PF09439.5 ESL11788.1 - 0.0099 15.1 0.0 0.026 13.7 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_17 PF13207.1 ESL11788.1 - 0.012 16.4 0.1 0.034 14.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESL11788.1 - 0.041 14.0 0.1 0.21 11.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 ESL11788.1 - 0.044 13.3 0.2 0.64 9.5 0.1 2.3 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 ESL11788.1 - 0.047 13.9 0.0 0.1 12.8 0.0 1.7 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 ESL11788.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL11788.1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IIGP PF05049.8 ESL11788.1 - 0.083 11.6 0.0 0.14 10.8 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC_sub_bind PF04392.7 ESL11788.1 - 0.089 11.7 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 ABC transporter substrate binding protein AAA_33 PF13671.1 ESL11788.1 - 0.093 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 ESL11788.1 - 0.098 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Septin PF00735.13 ESL11788.1 - 0.1 11.5 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_5 PF07728.9 ESL11788.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Myosin_head PF00063.16 ESL11789.1 - 3.4e-09 35.3 0.0 3.4e-09 35.3 0.0 2.8 2 2 0 2 2 2 1 Myosin head (motor domain) zf-CCCH_2 PF14608.1 ESL11790.1 - 4.8 7.3 6.2 0.65 10.0 0.2 2.7 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type zf-C3HC4_3 PF13920.1 ESL11791.1 - 0.00038 20.0 8.2 0.00066 19.2 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL11791.1 - 0.017 15.1 10.4 0.03 14.3 7.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3510 PF12022.3 ESL11791.1 - 0.053 13.6 0.2 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) zf-RING_5 PF14634.1 ESL11791.1 - 0.25 11.0 9.3 0.5 10.1 6.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 ESL11791.1 - 0.29 10.9 10.3 0.55 10.1 6.5 2.0 2 0 0 2 2 2 0 Ring finger domain zf-P11 PF03854.9 ESL11791.1 - 5.4 6.5 7.9 11 5.6 5.5 1.4 1 0 0 1 1 1 0 P-11 zinc finger CorA PF01544.13 ESL11792.1 - 0.75 8.7 2.5 0.5 9.3 0.5 1.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Ribosomal_L31e PF01198.14 ESL11794.1 - 5.2e-28 96.5 0.8 5.2e-28 96.5 0.6 1.6 2 0 0 2 2 2 1 Ribosomal protein L31e HhH-GPD PF00730.20 ESL11795.1 - 7.2e-18 64.8 0.0 1.4e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.1 ESL11795.1 - 5.1e-12 45.2 0.0 1.1e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.18 ESL11795.1 - 3.5e-06 26.3 0.4 1.5e-05 24.3 0.1 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 ESL11795.1 - 0.001 19.1 4.1 0.001 19.1 2.8 1.9 2 0 0 2 2 2 1 Iron-sulfur binding domain of endonuclease III HHH_5 PF14520.1 ESL11795.1 - 0.016 15.3 0.1 0.14 12.3 0.0 2.4 2 1 1 3 3 3 0 Helix-hairpin-helix domain PocR PF10114.4 ESL11795.1 - 0.13 11.3 0.1 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR Metallophos PF00149.23 ESL11796.1 - 0.00067 19.1 0.1 0.00099 18.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase M-factor PF03855.8 ESL11796.1 - 0.014 15.3 0.1 0.037 14.0 0.0 1.7 1 0 0 1 1 1 0 M-factor SNARE PF05739.14 ESL11797.1 - 0.00014 21.4 2.9 0.00014 21.4 2.0 2.0 2 0 0 2 2 2 1 SNARE domain FliJ PF02050.11 ESL11797.1 - 0.021 14.8 10.4 0.72 9.9 0.0 3.2 2 1 1 3 3 3 0 Flagellar FliJ protein DUF383 PF04063.9 ESL11797.1 - 0.023 14.2 0.3 0.19 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF383) Hypoth_Ymh PF09509.5 ESL11797.1 - 0.082 12.5 3.3 0.09 12.4 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) Sulfatase_C PF14707.1 ESL11797.1 - 0.34 11.1 1.6 0.82 9.9 0.0 2.2 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase Baculo_PEP_C PF04513.7 ESL11797.1 - 4.6 7.0 8.5 1.2 8.9 1.8 2.3 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC_2 PF13515.1 ESL11799.1 - 1.9e-14 53.6 30.6 3.1e-13 49.7 6.5 3.3 3 0 0 3 3 3 2 Fusaric acid resistance protein-like FUSC PF04632.7 ESL11799.1 - 0.0015 17.1 8.4 0.0015 17.1 5.8 2.1 2 0 0 2 2 2 1 Fusaric acid resistance protein family DUF883 PF05957.8 ESL11800.1 - 0.032 14.6 0.3 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) CheB_methylest PF01339.12 ESL11800.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 CheB methylesterase RNA_ligase PF09414.5 ESL11801.1 - 3e-51 173.8 0.0 4e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_M PF01068.16 ESL11801.1 - 0.00043 19.7 0.0 0.0009 18.6 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain FLILHELTA PF10306.4 ESL11801.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA MH1 PF03165.11 ESL11802.1 - 0.14 12.1 2.0 0.46 10.5 1.4 1.9 1 0 0 1 1 1 0 MH1 domain Abhydrolase_6 PF12697.2 ESL11804.1 - 1.6e-09 37.9 0.2 2.4e-09 37.4 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL11804.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family LRR_6 PF13516.1 ESL11805.1 - 2.4e-05 23.9 0.1 0.39 10.9 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.28 ESL11805.1 - 0.00014 21.3 0.4 0.11 12.6 0.0 3.7 3 0 0 3 3 3 1 Leucine Rich Repeat Pex24p PF06398.6 ESL11805.1 - 0.0012 17.7 0.1 0.0018 17.1 0.1 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin LRR_4 PF12799.2 ESL11805.1 - 0.0048 16.5 3.6 0.016 14.7 0.0 2.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) DUF4131 PF13567.1 ESL11805.1 - 0.0072 15.7 0.9 0.011 15.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Fucokinase PF07959.7 ESL11807.1 - 0.16 10.4 0.0 0.24 9.8 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase VWA_3 PF13768.1 ESL11808.1 - 1.8e-32 112.1 0.0 5.1e-32 110.7 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESL11808.1 - 2.9e-07 30.7 0.0 5.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 ESL11808.1 - 0.00063 19.1 0.0 0.0018 17.7 0.0 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF4424 PF14415.1 ESL11808.1 - 0.051 13.0 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4424) Corona_nucleoca PF00937.13 ESL11810.1 - 7.9 5.3 15.9 15 4.3 11.0 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Ribosomal_L7Ae PF01248.21 ESL11811.1 - 4.6e-23 80.5 0.9 5.8e-23 80.2 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ferritin PF00210.19 ESL11811.1 - 0.063 13.0 0.1 0.088 12.5 0.1 1.3 1 0 0 1 1 1 0 Ferritin-like domain SpoU_sub_bind PF08032.7 ESL11811.1 - 0.087 13.0 0.2 0.29 11.3 0.1 1.8 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding PEPCK_ATP PF01293.15 ESL11812.1 - 0.18 10.3 0.0 0.27 9.7 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase Lectin_leg-like PF03388.8 ESL11813.1 - 6.6e-21 74.4 0.0 9.5e-21 73.9 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family TPR_11 PF13414.1 ESL11815.1 - 0.047 13.3 2.0 0.76 9.4 0.1 3.2 3 0 0 3 3 3 0 TPR repeat TPR_14 PF13428.1 ESL11815.1 - 0.16 12.6 14.1 2.5 8.9 0.0 6.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11815.1 - 1.1 9.3 5.6 2.4 8.2 0.6 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1935 PF09149.5 ESL11816.1 - 8.2e-33 112.4 0.0 1e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) FadA PF09403.5 ESL11816.1 - 0.021 14.8 0.7 0.029 14.3 0.5 1.2 1 0 0 1 1 1 0 Adhesion protein FadA Antimicrobial11 PF08106.6 ESL11817.1 - 0.7 9.8 3.8 2.2 8.2 2.6 1.9 1 0 0 1 1 1 0 Formaecin family RolB_RolC PF02027.12 ESL11821.1 - 0.023 13.8 0.0 0.046 12.8 0.0 1.4 1 0 0 1 1 1 0 RolB/RolC glucosidase family Late_protein_L2 PF00513.13 ESL11821.1 - 0.15 10.8 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Late Protein L2 COX17 PF05051.8 ESL11825.1 - 1.3e-18 66.7 6.9 1.5e-18 66.4 4.8 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Apolipoprotein PF01442.13 ESL11827.1 - 0.0012 18.3 6.3 0.0012 18.3 4.4 3.4 3 0 0 3 3 3 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 ESL11827.1 - 0.019 14.8 4.6 0.07 12.9 3.2 2.0 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2973 PF11189.3 ESL11827.1 - 0.03 14.1 0.0 0.087 12.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) Ded_cyto PF06920.8 ESL11827.1 - 1.2 8.3 4.2 3.1 7.0 0.0 2.6 2 0 0 2 2 2 0 Dedicator of cytokinesis MMR_HSR1 PF01926.18 ESL11829.1 - 2.6e-08 33.8 0.0 1.4e-07 31.4 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL11829.1 - 4.9e-05 23.2 0.0 9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 ESL11829.1 - 0.18 11.0 0.0 11 5.3 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B Myosin_head PF00063.16 ESL11830.1 - 8.8e-21 73.6 0.1 1.3e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.22 ESL11830.1 - 0.27 11.0 5.4 0.18 11.5 0.2 3.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF3331 PF11811.3 ESL11831.1 - 1.6 8.3 9.1 22 4.6 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3331) C2 PF00168.25 ESL11832.1 - 0.0004 20.1 0.0 0.00091 19.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain Rootletin PF15035.1 ESL11832.1 - 0.00085 19.3 7.3 0.00085 19.3 5.0 7.0 2 2 4 6 6 6 1 Ciliary rootlet component, centrosome cohesion Tropomyosin_1 PF12718.2 ESL11832.1 - 0.0021 17.9 10.3 0.0021 17.9 7.2 7.3 5 2 1 7 7 7 1 Tropomyosin like BLOC1_2 PF10046.4 ESL11832.1 - 0.0069 16.5 3.4 0.0069 16.5 2.3 7.0 5 2 3 8 8 8 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.3 ESL11832.1 - 0.0091 15.7 13.1 0.0091 15.7 9.1 10.3 7 2 2 10 10 10 3 TATA element modulatory factor 1 DNA binding Reo_sigmaC PF04582.7 ESL11832.1 - 7.2 5.6 15.7 3.7 6.6 0.0 3.8 3 1 0 3 3 3 0 Reovirus sigma C capsid protein Thymidylate_kin PF02223.12 ESL11833.1 - 4e-19 68.7 0.0 5.3e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.1 ESL11833.1 - 4.5e-06 26.5 0.4 1.2e-05 25.2 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL11833.1 - 0.00011 22.5 0.0 0.00034 20.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESL11833.1 - 0.0043 17.0 0.3 0.009 16.0 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESL11833.1 - 0.013 16.2 0.0 0.021 15.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESL11833.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 ESL11833.1 - 0.13 11.3 0.1 0.52 9.3 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin TPR_11 PF13414.1 ESL11834.1 - 0.039 13.6 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 TPR repeat DUF2392 PF10288.4 ESL11838.1 - 3.7e-07 30.4 0.0 6.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) ATP_bind_3 PF01171.15 ESL11838.1 - 0.023 14.1 0.0 0.09 12.2 0.0 1.9 2 0 0 2 2 2 0 PP-loop family Ribosomal_L22e PF01776.12 ESL11839.1 - 7.6e-30 103.1 7.8 8.2e-30 103.0 5.4 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Glyco_hydro_56 PF01630.13 ESL11839.1 - 0.096 11.3 0.1 0.11 11.1 0.1 1.0 1 0 0 1 1 1 0 Hyaluronidase Transmemb_17 PF09799.4 ESL11840.1 - 9.2e-30 103.1 12.8 1.1e-29 102.9 8.9 1.1 1 0 0 1 1 1 1 Predicted membrane protein ATP-gua_Ptrans PF00217.14 ESL11841.1 - 2.8e-92 308.4 0.0 3.1e-92 308.2 0.0 1.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain DUF1342 PF07072.6 ESL11841.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) PDEase_I PF00233.14 ESL11844.1 - 3.6e-61 206.9 0.9 3.6e-61 206.9 0.6 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAS PF13851.1 ESL11844.1 - 0.0012 18.1 3.0 0.0023 17.1 2.1 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding FimP PF09766.4 ESL11844.1 - 0.0017 17.4 2.0 0.0028 16.7 1.4 1.2 1 0 0 1 1 1 1 Fms-interacting protein DUF4201 PF13870.1 ESL11844.1 - 0.21 11.0 5.2 0.38 10.1 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Ribosomal_S8e PF01201.17 ESL11845.1 - 1.6e-42 144.7 4.0 2e-42 144.4 2.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Herpes_DNAp_acc PF04929.7 ESL11846.1 - 3.7 6.4 6.8 6.2 5.6 4.7 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor PQQ_2 PF13360.1 ESL11847.1 - 4.5e-05 23.0 0.4 0.0093 15.4 0.1 3.2 3 1 1 4 4 4 1 PQQ-like domain BBS2_C PF14782.1 ESL11847.1 - 0.0019 16.8 0.1 0.012 14.2 0.0 2.2 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, C-terminal FG-GAP PF01839.18 ESL11847.1 - 0.0046 16.6 0.4 0.0046 16.6 0.3 2.0 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.1 ESL11847.1 - 0.0058 16.9 0.0 0.17 12.2 0.0 2.8 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Glucokinase PF02685.11 ESL11849.1 - 2.1e-19 69.4 0.0 7.6e-19 67.6 0.0 1.7 1 1 0 1 1 1 1 Glucokinase Pkinase PF00069.20 ESL11850.1 - 5.1e-60 202.8 0.0 6.5e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11850.1 - 2.1e-42 145.0 0.0 2.8e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11850.1 - 8.1e-10 38.1 0.0 1.6e-09 37.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like PH_9 PF15410.1 ESL11850.1 - 0.00017 21.7 0.0 0.007 16.5 0.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESL11850.1 - 0.00094 19.3 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESL11850.1 - 0.0031 17.7 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PaaSYMP PF14738.1 ESL11851.1 - 1.8e-47 160.9 6.1 1.8e-47 160.9 4.2 2.2 2 1 1 3 3 3 1 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 TPR_11 PF13414.1 ESL11852.1 - 4.6e-10 38.9 3.4 0.00015 21.3 0.1 3.2 2 1 1 3 3 3 3 TPR repeat TPR_17 PF13431.1 ESL11852.1 - 8.6e-09 34.9 0.3 0.33 11.2 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESL11852.1 - 4.7e-06 26.7 5.2 0.0047 17.4 0.1 4.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESL11852.1 - 0.00017 21.2 0.4 0.015 15.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESL11852.1 - 0.00042 20.1 3.3 0.15 11.9 1.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL11852.1 - 0.00054 20.2 1.3 1.4 9.2 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESL11852.1 - 0.017 15.7 6.6 0.17 12.5 0.4 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TBCA PF02970.11 ESL11852.1 - 0.063 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Tubulin binding cofactor A TPR_8 PF13181.1 ESL11852.1 - 0.11 12.3 0.0 25 4.9 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Pentapeptide_4 PF13599.1 ESL11853.1 - 4.5e-05 23.1 11.4 0.0071 16.1 7.9 2.5 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 ESL11853.1 - 0.00022 21.0 16.3 0.0056 16.5 1.5 3.5 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.17 ESL11853.1 - 0.0046 16.1 0.0 0.49 9.6 0.0 3.5 4 0 0 4 4 4 1 Pentapeptide repeats (8 copies) Pro_isomerase PF00160.16 ESL11854.1 - 1.2e-30 106.7 0.0 1.9e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_60s PF00428.14 ESL11854.1 - 0.03 14.7 5.5 0.047 14.0 3.8 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3740 PF12548.3 ESL11854.1 - 0.74 10.0 2.7 1.1 9.4 1.9 1.2 1 0 0 1 1 1 0 Sulfatase protein Nucleoside_tran PF01733.13 ESL11855.1 - 9.6e-33 113.6 8.2 9.6e-33 113.6 5.7 1.9 2 1 0 2 2 2 1 Nucleoside transporter COX14 PF14880.1 ESL11855.1 - 0.12 12.0 0.1 0.12 12.0 0.0 2.8 3 0 0 3 3 3 0 Cytochrome oxidase c assembly Pro_isomerase PF00160.16 ESL11856.1 - 3.4e-05 24.1 0.0 4.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GFRP PF06399.8 ESL11856.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) FHA PF00498.21 ESL11858.1 - 0.00043 20.3 0.0 0.0022 18.0 0.0 2.2 3 0 0 3 3 3 1 FHA domain MMR_HSR1_C PF08438.5 ESL11860.1 - 0.013 15.7 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 GTPase of unknown function C-terminal NPV_P10 PF05531.7 ESL11861.1 - 4.7 7.5 6.4 11 6.3 0.1 3.7 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Z1 PF10593.4 ESL11861.1 - 8.1 5.5 11.1 3.1 6.9 1.3 2.6 1 1 1 2 2 2 0 Z1 domain GRIM-19 PF06212.7 ESL11863.1 - 1.6e-08 34.2 0.0 1.9e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 GRIM-19 protein NTP_transferase PF00483.18 ESL11866.1 - 3e-46 157.7 0.0 3.8e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 ESL11866.1 - 2.6e-12 47.1 0.0 3.4e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 ESL11866.1 - 1e-10 40.6 12.4 6.5e-08 31.7 1.1 4.0 2 1 3 5 5 5 4 Bacterial transferase hexapeptide (six repeats) CTP_transf_3 PF02348.14 ESL11866.1 - 0.022 14.3 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase Hexapep_2 PF14602.1 ESL11866.1 - 0.024 14.2 7.1 0.11 12.1 1.8 3.5 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 ESL11866.1 - 0.09 11.3 0.3 1.3 7.4 0.1 2.2 1 1 1 2 2 2 0 L-fucokinase IspD PF01128.14 ESL11866.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NIF PF03031.13 ESL11867.1 - 1.9e-28 99.1 0.0 2.7e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.7 ESL11867.1 - 8.6e-05 21.6 0.0 0.00012 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF705) HAD_2 PF13419.1 ESL11867.1 - 0.033 14.3 0.0 0.093 12.9 0.0 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Nucleoside_tran PF01733.13 ESL11870.1 - 1.1e-30 106.9 0.8 1.1e-30 106.9 0.6 2.0 2 1 0 2 2 2 1 Nucleoside transporter Vma12 PF11712.3 ESL11870.1 - 0.14 11.8 2.6 2.4 7.8 0.2 2.8 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Glyco_tranf_2_3 PF13641.1 ESL11871.1 - 0.0065 16.3 0.0 0.0091 15.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 ATP_bind_1 PF03029.12 ESL11873.1 - 5.2e-51 173.4 0.0 4.9e-50 170.2 0.0 2.0 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.1 ESL11873.1 - 0.0033 17.2 0.1 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESL11873.1 - 0.013 15.6 0.0 0.041 14.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESL11873.1 - 0.013 16.3 1.4 0.029 15.2 1.0 2.0 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ESL11873.1 - 0.048 13.8 0.0 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESL11873.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 ESL11873.1 - 0.14 12.4 0.3 0.36 11.1 0.2 1.7 1 0 0 1 1 1 0 AAA domain DUF3819 PF12842.2 ESL11873.1 - 0.16 11.6 1.5 6.9 6.3 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3819) RNB PF00773.14 ESL11874.1 - 3.1e-61 207.4 0.0 4.6e-61 206.9 0.0 1.2 1 0 0 1 1 1 1 RNB domain zf-RanBP PF00641.13 ESL11875.1 - 1.4e-16 59.2 97.3 5.1e-07 28.6 1.2 9.6 8 1 1 9 9 9 9 Zn-finger in Ran binding protein and others DZR PF12773.2 ESL11875.1 - 1.9e-14 53.1 71.8 0.00072 19.3 7.8 7.1 4 2 3 7 7 7 7 Double zinc ribbon DUF1751 PF08551.5 ESL11876.1 - 3.8e-05 23.9 3.4 6.6e-05 23.1 2.4 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 ESL11876.1 - 0.0022 18.0 7.1 0.0047 16.9 4.9 1.6 1 0 0 1 1 1 1 Rhomboid family SAM_decarbox PF01536.11 ESL11877.1 - 3.3e-15 55.5 0.1 1.6e-10 40.1 0.0 2.4 2 1 0 2 2 2 2 Adenosylmethionine decarboxylase TPR_19 PF14559.1 ESL11878.1 - 0.037 14.3 0.2 0.2 12.0 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat PEP_mutase PF13714.1 ESL11879.1 - 1.4e-68 230.6 1.0 1.8e-68 230.3 0.7 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.16 ESL11879.1 - 0.021 13.0 0.1 0.11 10.7 0.0 1.9 1 1 1 2 2 2 0 Isocitrate lyase family L27 PF02828.11 ESL11879.1 - 0.11 12.1 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 L27 domain NIF PF03031.13 ESL11881.1 - 1e-13 51.2 0.0 1.2e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESL11881.1 - 0.0041 17.3 0.0 0.12 12.5 0.0 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase SRR1 PF07985.7 ESL11882.1 - 0.029 14.3 0.0 0.095 12.6 0.0 1.9 2 0 0 2 2 2 0 SRR1 MMR_HSR1 PF01926.18 ESL11885.1 - 3.9e-09 36.4 0.0 1.3e-08 34.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL11885.1 - 9e-06 25.6 0.0 1.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 ESL11885.1 - 0.045 13.0 0.0 2.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF258 PF03193.11 ESL11885.1 - 0.077 12.1 0.0 0.3 10.2 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function, DUF258 RNA_helicase PF00910.17 ESL11885.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Ras PF00071.17 ESL11886.1 - 2.9e-48 163.3 0.0 3.4e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESL11886.1 - 3.6e-14 53.2 0.0 5.3e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESL11886.1 - 2.6e-09 36.5 0.0 3.2e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESL11886.1 - 4.6e-05 22.6 0.0 5e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESL11886.1 - 0.00026 20.4 0.0 0.0038 16.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESL11886.1 - 0.0094 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESL11886.1 - 0.055 14.3 0.0 0.11 13.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain TOBE_3 PF12857.2 ESL11887.1 - 0.12 12.3 0.1 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 TOBE-like domain TP_methylase PF00590.15 ESL11888.1 - 1.2e-17 64.2 0.1 1.8e-17 63.7 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.1 ESL11888.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4434) HTHP PF11534.3 ESL11888.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Hexameric tyrosine-coordinated heme protein (HTHP) Pep3_Vps18 PF05131.9 ESL11889.1 - 2.6e-05 23.6 0.0 4.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family PE-PPE PF08237.6 ESL11889.1 - 0.076 12.4 0.1 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain PC_rep PF01851.17 ESL11891.1 - 7.7e-19 66.7 15.2 0.0004 20.4 0.0 7.8 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.1 ESL11891.1 - 2.2e-12 47.0 3.0 3e-07 30.6 0.0 5.6 3 1 2 5 5 5 2 HEAT repeats DUF1612 PF07756.7 ESL11892.1 - 0.046 13.8 0.1 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) PCI PF01399.22 ESL11893.1 - 2.3e-16 60.0 0.8 5e-16 58.9 0.5 1.6 1 0 0 1 1 1 1 PCI domain TPR_4 PF07721.9 ESL11893.1 - 0.18 12.2 8.6 1.5 9.4 0.5 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DDRGK PF09756.4 ESL11893.1 - 2.3 7.6 14.2 0.074 12.4 0.1 2.5 2 0 0 2 2 2 0 DDRGK domain PHO4 PF01384.15 ESL11894.1 - 1.4e-98 329.5 18.4 1.7e-98 329.3 12.8 1.0 1 0 0 1 1 1 1 Phosphate transporter family WD40 PF00400.27 ESL11895.1 - 2.5e-09 36.6 2.7 0.19 11.6 0.0 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat PS_Dcarbxylase PF02666.10 ESL11895.1 - 0.1 11.8 0.0 0.99 8.6 0.0 2.2 1 1 0 1 1 1 0 Phosphatidylserine decarboxylase PAGK PF15284.1 ESL11895.1 - 0.36 10.6 0.0 0.36 10.6 0.0 2.5 3 0 0 3 3 3 0 Phage-encoded virulence factor MBOAT_2 PF13813.1 ESL11896.1 - 0.00032 20.7 2.6 0.0025 17.8 0.3 2.6 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family TPT PF03151.11 ESL11896.1 - 0.0042 16.7 11.1 0.0042 16.7 7.7 2.9 2 1 1 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 ESL11896.1 - 0.012 15.6 3.2 0.012 15.6 2.2 3.5 2 1 0 3 3 3 0 EamA-like transporter family HECT PF00632.20 ESL11897.1 - 6.5e-12 45.2 0.0 0.00089 18.5 0.0 3.1 3 0 0 3 3 3 3 HECT-domain (ubiquitin-transferase) MSA-2c PF12238.3 ESL11897.1 - 0.13 11.9 0.1 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c COX17 PF05051.8 ESL11898.1 - 7.4e-06 25.8 0.3 1.1e-05 25.2 0.2 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) EF-hand_1 PF00036.27 ESL11899.1 - 5.5e-12 44.0 3.4 1.2e-06 27.3 0.0 3.0 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESL11899.1 - 2.7e-10 39.2 1.1 5.8e-05 22.6 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESL11899.1 - 2.3e-08 34.0 1.3 6.5e-08 32.5 0.1 2.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL11899.1 - 2.8e-06 26.8 6.0 6.7e-05 22.4 0.2 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 ESL11899.1 - 6.8e-06 25.1 5.1 9.7e-05 21.5 0.0 3.5 3 1 0 3 3 3 1 EF hand EF-hand_10 PF14788.1 ESL11899.1 - 0.023 14.3 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 EF hand COX6B PF02297.12 ESL11900.1 - 0.13 12.3 1.8 0.22 11.5 1.2 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Robl_LC7 PF03259.12 ESL11901.1 - 2.9e-12 45.9 0.1 3.8e-12 45.6 0.1 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain Toxin_36 PF10550.4 ESL11901.1 - 0.014 16.4 0.5 0.039 15.0 0.4 1.7 1 0 0 1 1 1 0 Conantokin-G mollusc-toxin LEA_4 PF02987.11 ESL11901.1 - 0.058 13.2 0.7 0.11 12.3 0.5 1.4 1 0 0 1 1 1 0 Late embryogenesis abundant protein SUI1 PF01253.17 ESL11902.1 - 2e-15 56.3 0.1 6.3e-15 54.7 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor SUI1 PUA PF01472.15 ESL11902.1 - 0.00075 19.1 0.1 0.17 11.6 0.0 2.7 2 0 0 2 2 2 2 PUA domain Adenosine_kin PF04008.9 ESL11902.1 - 0.059 12.8 0.1 0.26 10.7 0.1 2.0 2 0 0 2 2 2 0 Adenosine specific kinase Radical_SAM PF04055.16 ESL11903.1 - 3.1e-22 79.4 0.1 5.7e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 ESL11903.1 - 1.4e-20 73.1 0.1 2.8e-14 52.9 0.0 2.8 2 0 0 2 2 2 2 Wyosine base formation Flavodoxin_1 PF00258.20 ESL11903.1 - 2.8e-12 46.8 0.2 1.3e-11 44.6 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin CMD PF02627.15 ESL11903.1 - 0.097 12.5 0.5 1.8 8.4 0.2 2.4 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family ABC_tran PF00005.22 ESL11904.1 - 6.5e-13 49.1 0.1 3.8e-12 46.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 ESL11904.1 - 0.00043 20.3 0.0 0.00059 19.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 ESL11904.1 - 0.01 15.7 0.1 0.12 12.2 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 ESL11904.1 - 0.03 13.5 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain PQQ_2 PF13360.1 ESL11905.1 - 0.00049 19.6 4.8 0.16 11.3 2.5 3.3 1 1 1 2 2 2 2 PQQ-like domain ATG16 PF08614.6 ESL11905.1 - 0.0073 16.1 28.3 0.042 13.6 5.8 4.0 2 1 2 4 4 4 2 Autophagy protein 16 (ATG16) DUF3828 PF12883.2 ESL11905.1 - 0.063 13.2 0.4 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) Reo_sigmaC PF04582.7 ESL11905.1 - 0.15 11.1 12.8 0.078 12.1 4.4 2.6 2 1 1 3 3 3 0 Reovirus sigma C capsid protein PQQ_3 PF13570.1 ESL11905.1 - 0.2 11.9 8.2 5 7.5 0.2 4.1 4 0 0 4 4 3 0 PQQ-like domain CtaG_Cox11 PF04442.9 ESL11905.1 - 0.23 11.2 0.0 0.48 10.2 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein CtaG/Cox11 WD40 PF00400.27 ESL11905.1 - 0.28 11.1 2.7 2 8.4 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat CENP-F_leu_zip PF10473.4 ESL11905.1 - 0.71 9.7 27.7 0.6 9.9 8.4 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.3 ESL11905.1 - 1.1 8.4 15.8 3 7.0 1.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Tropomyosin_1 PF12718.2 ESL11905.1 - 1.2 8.9 22.0 0.11 12.3 4.7 3.0 1 1 1 2 2 2 0 Tropomyosin like AAA_13 PF13166.1 ESL11905.1 - 1.3 7.4 13.6 2 6.7 9.4 1.4 1 1 0 1 1 1 0 AAA domain GAS PF13851.1 ESL11905.1 - 1.3 8.2 20.9 0.24 10.5 8.0 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding WD40_alt PF14077.1 ESL11905.1 - 2.1 8.0 8.2 0.16 11.6 0.2 3.0 3 0 0 3 3 3 0 Alternative WD40 repeat motif Atg14 PF10186.4 ESL11905.1 - 2.2 7.1 23.7 0.42 9.5 10.2 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 ESL11905.1 - 8.2 5.3 23.6 2.2 7.2 1.4 2.8 1 1 2 3 3 3 0 Autophagy protein Apg6 PIP5K PF01504.13 ESL11906.1 - 3.8e-55 186.7 0.0 7.9e-55 185.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_7 PF13499.1 ESL11908.1 - 0.00021 21.3 0.2 1.2 9.3 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 ESL11908.1 - 0.021 14.1 0.0 7.3 6.1 0.0 2.8 2 0 0 2 2 2 0 EF hand zf-CCCH PF00642.19 ESL11909.1 - 2.4e-15 55.7 41.1 0.00057 19.4 1.4 5.8 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHC PF00098.18 ESL11909.1 - 2.1e-07 30.5 14.3 0.0015 18.3 4.3 3.3 2 0 0 2 2 2 2 Zinc knuckle zf-C3H1 PF10650.4 ESL11909.1 - 0.056 12.9 0.1 0.056 12.9 0.1 3.1 3 0 0 3 3 3 0 Putative zinc-finger domain zf-CCHC_3 PF13917.1 ESL11909.1 - 0.069 12.8 0.0 0.069 12.8 0.0 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCCH_2 PF14608.1 ESL11909.1 - 0.15 12.1 0.2 0.15 12.1 0.1 5.6 5 1 0 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type zf-CCHC_2 PF13696.1 ESL11909.1 - 0.74 9.3 17.2 0.16 11.5 1.6 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.1 ESL11909.1 - 2.4 7.8 11.5 0.45 10.2 3.4 2.6 2 0 0 2 2 2 0 Zinc knuckle HORMA PF02301.13 ESL11910.1 - 4.1e-33 114.6 0.0 4.7e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.4 ESL11910.1 - 0.096 12.0 0.0 2.9 7.2 0.0 2.0 2 0 0 2 2 2 0 Autophagy-related protein 13 ABC1 PF03109.11 ESL11911.1 - 6.7e-30 103.5 0.0 1.8e-29 102.1 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 ESL11911.1 - 1.4e-06 28.2 0.2 5.1e-06 26.4 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family CagA PF03507.8 ESL11911.1 - 0.092 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 CagA exotoxin DUF1682 PF07946.9 ESL11912.1 - 0.089 11.6 4.9 0.15 10.8 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CPSF_A PF03178.10 ESL11913.1 - 2e-45 155.3 0.0 4.7e-45 154.0 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.4 ESL11913.1 - 3e-07 28.9 0.0 4.5e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Vps5 PF09325.5 ESL11914.1 - 1.9e-22 79.6 6.8 2.9e-22 79.1 4.7 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 ESL11914.1 - 6.3e-18 64.6 0.0 1.3e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.4 ESL11914.1 - 2.9e-07 29.9 4.3 5.1e-06 25.9 3.0 2.2 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein BAR PF03114.13 ESL11914.1 - 1.3e-05 24.8 5.8 2.7e-05 23.7 4.0 1.5 1 0 0 1 1 1 1 BAR domain Cut12 PF11500.3 ESL11914.1 - 0.18 11.5 4.0 0.27 10.9 2.2 1.7 1 1 0 1 1 1 0 Spindle pole body formation-associated protein TMF_TATA_bd PF12325.3 ESL11914.1 - 0.59 9.8 9.5 1.2 8.9 0.2 3.0 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Takusan PF04822.8 ESL11914.1 - 0.59 9.9 2.8 17 5.2 0.0 3.0 3 0 0 3 3 3 0 Takusan SlyX PF04102.7 ESL11914.1 - 1.5 9.2 3.9 41 4.6 0.8 3.4 2 1 1 3 3 3 0 SlyX Surp PF01805.15 ESL11915.1 - 1.9e-10 40.1 4.1 9.9e-08 31.5 0.0 2.3 2 0 0 2 2 2 2 Surp module RCC1 PF00415.13 ESL11916.1 - 1.2e-37 127.9 4.8 2.9e-11 43.3 0.0 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESL11916.1 - 2e-23 81.4 18.8 1.3e-07 31.0 0.7 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB_2 PF02214.17 ESL11916.1 - 1.4e-09 38.0 0.0 2.2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TSC22 PF01166.13 ESL11917.1 - 0.05 13.5 6.5 1.1 9.2 1.4 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family End3 PF12761.2 ESL11917.1 - 0.058 13.0 2.1 0.091 12.3 1.4 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DivIC PF04977.10 ESL11917.1 - 0.059 12.8 7.7 0.53 9.8 1.4 2.3 2 0 0 2 2 2 0 Septum formation initiator TBPIP PF07106.8 ESL11917.1 - 0.14 11.6 4.1 0.23 10.9 2.8 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CENP-H PF05837.7 ESL11917.1 - 0.39 10.9 5.4 0.79 9.9 3.8 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FUSC PF04632.7 ESL11917.1 - 0.42 8.9 12.5 0.53 8.6 8.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.4 ESL11917.1 - 0.49 9.2 10.1 0.78 8.6 7.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HALZ PF02183.13 ESL11917.1 - 0.6 9.8 8.7 0.39 10.4 1.9 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper IncA PF04156.9 ESL11917.1 - 1.2 8.7 6.4 2 7.9 4.5 1.3 1 0 0 1 1 1 0 IncA protein MMR_HSR1 PF01926.18 ESL11918.1 - 1.1e-10 41.4 0.0 4.8e-09 36.1 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESL11918.1 - 0.00016 20.8 0.0 0.00033 19.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESL11918.1 - 0.0049 16.9 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.13 ESL11918.1 - 0.027 13.7 0.0 0.057 12.6 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.18 ESL11918.1 - 0.041 13.6 0.3 2.1 8.1 0.0 2.5 1 1 0 2 2 2 0 Dynamin family PPTA PF01239.17 ESL11919.1 - 1.3e-26 90.7 9.5 4.5e-07 28.9 0.0 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat PRP3 PF08572.5 ESL11920.1 - 8.3e-42 143.0 3.4 8.3e-42 143.0 2.4 2.0 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 ESL11920.1 - 3.5e-26 91.3 0.0 7.4e-26 90.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) PH PF00169.24 ESL11921.1 - 4.6e-13 49.2 0.0 8.8e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESL11921.1 - 0.0012 19.0 0.1 0.0027 17.9 0.0 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.1 ESL11921.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 1 0 1 1 1 0 PH domain Glucosamine_iso PF01182.15 ESL11922.1 - 3.6e-48 163.9 0.0 4.2e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase BLOC1_2 PF10046.4 ESL11923.1 - 1.2e-19 70.2 0.0 1.4e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 SAP PF02037.22 ESL11924.1 - 1.8e-12 46.4 0.0 3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 SAP domain HA PF03457.9 ESL11924.1 - 0.11 12.6 1.0 0.22 11.6 0.0 1.9 2 0 0 2 2 2 0 Helicase associated domain Med3 PF11593.3 ESL11926.1 - 2.1 7.4 13.5 2.8 7.0 9.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF962 PF06127.6 ESL11928.1 - 9.4e-22 76.7 0.3 1.1e-21 76.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF962) DOT1 PF08123.8 ESL11929.1 - 1e-22 80.5 0.0 1.2e-22 80.2 0.0 1.0 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 ESL11929.1 - 3.1e-08 34.1 0.0 4.8e-08 33.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESL11929.1 - 5e-07 29.7 0.2 6.4e-07 29.4 0.2 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESL11929.1 - 8.9e-07 28.6 0.0 1.1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESL11929.1 - 1.6e-05 25.3 0.0 3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL11929.1 - 3e-05 24.3 0.0 5.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESL11929.1 - 0.0031 17.2 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.8 ESL11929.1 - 0.0089 16.1 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_4 PF02390.12 ESL11929.1 - 0.032 13.2 0.0 0.048 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.15 ESL11929.1 - 0.033 13.2 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 ESL11929.1 - 0.04 13.3 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MetW PF07021.7 ESL11929.1 - 0.043 13.1 0.0 0.074 12.4 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.7 ESL11929.1 - 0.049 14.1 0.0 0.082 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 ESL11929.1 - 0.056 13.0 0.0 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 BRCT PF00533.21 ESL11930.1 - 9.8e-08 32.0 0.0 2.7e-07 30.6 0.0 1.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 ESL11930.1 - 0.015 15.1 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 twin BRCT domain PPR PF01535.15 ESL11931.1 - 5.9e-05 22.7 0.1 0.008 16.0 0.0 3.8 4 0 0 4 4 4 1 PPR repeat PPR_2 PF13041.1 ESL11931.1 - 0.02 14.8 0.0 0.25 11.3 0.0 2.7 2 0 0 2 2 2 0 PPR repeat family Ribosomal_60s PF00428.14 ESL11931.1 - 3.2 8.2 6.3 0.97 9.8 0.3 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein FAA_hydrolase_N PF09298.6 ESL11932.1 - 0.068 13.1 4.5 0.25 11.3 3.1 2.0 1 1 0 1 1 1 0 Fumarylacetoacetase N-terminal Mt_ATP-synt_B PF05405.9 ESL11932.1 - 0.37 10.2 8.7 0.61 9.5 5.3 1.9 1 1 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) HALZ PF02183.13 ESL11932.1 - 4.2 7.1 8.9 3.9 7.2 0.1 3.4 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF2305 PF10230.4 ESL11933.1 - 3.4e-62 210.2 0.0 4e-62 210.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 ESL11933.1 - 9.9e-11 41.9 0.2 1.2e-10 41.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL11933.1 - 6.6e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Pkr1 PF08636.5 ESL11934.1 - 0.00013 21.9 7.1 0.00017 21.5 4.9 1.1 1 0 0 1 1 1 1 ER protein Pkr1 DUF1632 PF07857.7 ESL11934.1 - 0.026 13.8 0.1 0.029 13.6 0.0 1.1 1 0 0 1 1 1 0 CEO family (DUF1632) DUF2244 PF10003.4 ESL11934.1 - 0.049 12.9 0.3 0.051 12.9 0.2 1.1 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) 2TM PF13239.1 ESL11934.1 - 0.12 12.4 1.9 0.19 11.8 1.3 1.3 1 0 0 1 1 1 0 2TM domain DUF4175 PF13779.1 ESL11934.1 - 0.2 9.2 1.0 0.21 9.2 0.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ATP_bind_1 PF03029.12 ESL11936.1 - 4e-59 200.0 0.0 4.7e-59 199.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 ESL11936.1 - 2.3e-05 25.2 0.7 5.8e-05 23.8 0.0 2.0 2 2 0 2 2 2 1 AAA domain CbiA PF01656.18 ESL11936.1 - 5.7e-05 22.6 0.0 0.00016 21.1 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.2 ESL11936.1 - 0.00081 18.9 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain SRP54 PF00448.17 ESL11936.1 - 0.0024 17.3 0.0 0.0067 15.8 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.1 ESL11936.1 - 0.0029 17.2 0.0 0.0057 16.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain ABC_tran PF00005.22 ESL11936.1 - 0.0033 17.7 0.0 0.0066 16.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_19 PF13245.1 ESL11936.1 - 0.0033 17.1 0.0 0.0067 16.1 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 ESL11936.1 - 0.0041 17.2 0.1 0.0095 16.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 ESL11936.1 - 0.0045 16.9 0.0 0.014 15.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.1 ESL11936.1 - 0.0046 16.3 0.1 0.025 13.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESL11936.1 - 0.0047 16.8 0.0 0.0095 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 ESL11936.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.1 ESL11936.1 - 0.012 15.5 0.0 0.036 14.0 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.9 ESL11936.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 ESL11936.1 - 0.014 14.8 0.1 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 ESL11936.1 - 0.017 15.3 0.2 0.052 13.8 0.0 2.1 2 1 0 2 2 2 0 AAA domain DUF258 PF03193.11 ESL11936.1 - 0.035 13.2 0.0 0.064 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 ESL11936.1 - 0.04 13.3 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 ESL11936.1 - 0.074 13.2 0.0 0.36 11.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.1 ESL11936.1 - 0.085 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 ESL11936.1 - 0.092 11.7 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_28 PF13521.1 ESL11936.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ESL11936.1 - 0.13 11.9 0.4 0.49 10.0 0.0 2.1 3 0 0 3 3 3 0 NACHT domain ArgK PF03308.11 ESL11936.1 - 0.13 10.9 0.0 0.22 10.2 0.0 1.3 1 0 0 1 1 1 0 ArgK protein Thymidylate_kin PF02223.12 ESL11936.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase MobB PF03205.9 ESL11936.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.16 ESL11936.1 - 0.16 11.1 0.1 0.25 10.4 0.1 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ArsA_ATPase PF02374.10 ESL11936.1 - 0.19 10.7 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase DNA_pol_B PF00136.16 ESL11939.1 - 1.3e-120 403.4 0.4 2.3e-120 402.5 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESL11939.1 - 1.1e-42 146.0 0.0 2.1e-42 145.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.5 ESL11939.1 - 0.001 18.4 1.1 0.013 14.8 1.1 2.3 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger Fascin PF06268.8 ESL11941.1 - 0.02 14.9 0.0 0.075 13.1 0.0 1.9 2 0 0 2 2 2 0 Fascin domain Hist_deacetyl PF00850.14 ESL11942.1 - 9.6e-57 192.6 0.0 1.5e-56 191.9 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Kinesin PF00225.18 ESL11943.1 - 5.9e-84 281.6 0.0 9.6e-84 280.9 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Calpain_III PF01067.17 ESL11943.1 - 3.8e-29 101.2 0.1 3.9e-21 75.2 0.0 2.7 2 0 0 2 2 2 2 Calpain large subunit, domain III Arm PF00514.18 ESL11943.1 - 7.6e-08 31.9 0.1 0.26 11.1 0.0 5.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat CDC14 PF08045.6 ESL11943.1 - 0.0027 16.8 0.1 0.035 13.2 0.0 2.2 1 1 1 2 2 2 1 Cell division control protein 14, SIN component V-ATPase_H_C PF11698.3 ESL11943.1 - 0.093 12.6 0.1 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 V-ATPase subunit H Pox_A_type_inc PF04508.7 ESL11943.1 - 0.099 12.4 9.4 0.04 13.6 0.9 3.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat AAA_10 PF12846.2 ESL11943.1 - 0.22 10.9 1.9 1.9 7.8 0.8 2.6 2 1 0 2 2 2 0 AAA-like domain HEAT_EZ PF13513.1 ESL11943.1 - 1.5 9.3 4.1 5.3 7.6 0.2 2.9 1 1 0 2 2 2 0 HEAT-like repeat Actin PF00022.14 ESL11944.1 - 1.3e-98 329.9 0.0 1.6e-98 329.7 0.0 1.0 1 0 0 1 1 1 1 Actin Rad21_Rec8_N PF04825.8 ESL11945.1 - 9.5e-32 109.2 0.0 1.7e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 ESL11945.1 - 8.3e-09 34.5 0.3 5.6e-08 31.8 0.1 2.3 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 ESL11945.1 - 0.0004 20.0 0.6 0.0041 16.7 0.0 2.2 2 0 0 2 2 2 1 ScpA/B protein UAA PF08449.6 ESL11946.1 - 1.2e-45 155.6 11.9 1.2e-45 155.6 8.3 2.0 2 1 0 2 2 2 1 UAA transporter family TPT PF03151.11 ESL11946.1 - 5.6e-07 29.3 2.6 5.6e-07 29.3 1.8 2.8 3 1 0 3 3 3 1 Triose-phosphate Transporter family Pkinase PF00069.20 ESL11947.1 - 4.2e-56 189.9 0.0 4.9e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11947.1 - 4.7e-28 97.9 0.0 9.7e-28 96.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11947.1 - 0.00063 18.8 0.0 0.00095 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like EF-hand_7 PF13499.1 ESL11948.1 - 1.1e-10 41.4 0.9 1.1e-10 41.4 0.6 2.9 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 ESL11948.1 - 1.6e-07 30.8 1.5 4.1e-06 26.2 0.5 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 ESL11948.1 - 7.6e-07 28.1 0.5 1.8e-06 27.0 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 ESL11948.1 - 1.5e-06 27.0 1.7 9.7e-06 24.5 0.1 2.8 3 0 0 3 3 3 1 EF hand EF-hand_10 PF14788.1 ESL11948.1 - 0.00018 21.1 0.2 0.00043 19.8 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 ESL11948.1 - 0.0006 19.4 2.7 0.0044 16.7 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.4 ESL11948.1 - 0.042 13.8 0.0 0.042 13.8 0.0 3.7 3 1 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region CP12 PF02672.10 ESL11948.1 - 0.18 12.3 0.0 0.18 12.3 0.0 6.0 2 1 3 6 6 6 0 CP12 domain Reo_sigmaC PF04582.7 ESL11948.1 - 0.78 8.8 9.3 2.9 6.9 0.8 2.3 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF948 PF06103.6 ESL11948.1 - 2.9 7.8 13.2 18 5.2 0.2 4.2 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF3584 PF12128.3 ESL11948.1 - 4.1 4.6 68.7 0.13 9.5 27.8 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Tropomyosin PF00261.15 ESL11948.1 - 8.3 5.4 73.1 24 3.8 12.9 3.6 1 1 1 2 2 2 0 Tropomyosin DUF2411 PF10304.4 ESL11949.1 - 0.57 9.7 2.1 1.2 8.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2411) Aa_trans PF01490.13 ESL11950.1 - 4.5e-45 153.8 29.0 5.7e-45 153.5 20.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ax_dynein_light PF10211.4 ESL11952.1 - 0.29 10.9 0.0 0.29 10.9 0.0 5.6 5 1 1 6 6 6 0 Axonemal dynein light chain DUF4239 PF14023.1 ESL11953.1 - 0.054 12.8 0.1 0.18 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) WD40 PF00400.27 ESL11954.1 - 0.014 15.2 1.0 23 5.0 0.0 4.0 3 1 0 3 3 3 0 WD domain, G-beta repeat Thiol_cytolysin PF01289.14 ESL11954.1 - 0.083 11.2 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 Thiol-activated cytolysin Ribosomal_S8 PF00410.14 ESL11956.1 - 0.00016 21.4 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 SF3b10 PF07189.6 ESL11956.1 - 0.04 13.7 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Splicing factor 3B subunit 10 (SF3b10) zf-met2 PF12907.2 ESL11957.1 - 2.3e-07 30.6 0.1 2.3e-07 30.6 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding 4F5 PF04419.9 ESL11957.1 - 0.0026 18.4 11.0 0.0026 18.4 7.6 1.6 2 0 0 2 2 2 1 4F5 protein family zf-C2H2_4 PF13894.1 ESL11957.1 - 0.014 15.7 1.5 0.052 13.8 0.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESL11957.1 - 0.031 14.3 2.8 0.27 11.3 1.9 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Eapp_C PF10238.4 ESL11957.1 - 0.19 11.5 2.8 0.29 11.0 2.0 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein UCH PF00443.24 ESL11958.1 - 3e-50 170.8 0.0 4.2e-50 170.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESL11958.1 - 4.4e-23 82.1 0.0 6.9e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MCPsignal PF00015.16 ESL11959.1 - 0.25 10.8 19.9 1.7 8.1 3.4 3.4 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DASH_Dam1 PF08653.5 ESL11959.1 - 0.85 9.4 3.2 11 5.9 0.1 3.6 3 0 0 3 3 3 0 DASH complex subunit Dam1 Reo_sigmaC PF04582.7 ESL11959.1 - 3.1 6.8 15.1 11 5.1 2.9 3.4 1 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF2316 PF10078.4 ESL11959.1 - 7.3 6.6 14.5 4.5 7.3 0.1 4.0 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) Pkinase PF00069.20 ESL11961.1 - 5.9e-05 22.3 0.0 9.2e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESL11963.1 - 4.4e-57 193.2 0.0 6.4e-57 192.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11963.1 - 2e-28 99.2 0.0 3.9e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL11963.1 - 2e-09 36.8 0.1 2.9e-06 26.4 0.0 2.6 1 1 0 2 2 2 2 Kinase-like APH PF01636.18 ESL11963.1 - 5.5e-05 23.0 1.1 0.024 14.3 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESL11963.1 - 0.0043 16.1 0.0 0.0097 14.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.4 ESL11963.1 - 0.058 11.9 0.0 0.093 11.2 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC ATP-synt_C PF00137.16 ESL11964.1 - 3.4e-30 103.7 28.5 7.5e-18 64.1 5.8 2.4 2 0 0 2 2 2 2 ATP synthase subunit C BCLP PF12304.3 ESL11964.1 - 0.086 12.2 1.3 0.14 11.5 0.6 1.6 1 1 0 1 1 1 0 Beta-casein like protein DUF4064 PF13273.1 ESL11964.1 - 0.17 12.0 10.5 2.6 8.2 2.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) GerA PF03323.8 ESL11964.1 - 2.8 5.9 6.2 3.9 5.4 0.7 2.1 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein DUF4231 PF14015.1 ESL11964.1 - 4 7.4 5.0 49 3.9 3.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) DUF1193 PF06702.7 ESL11966.1 - 9.7e-06 25.1 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1193) VPS9 PF02204.13 ESL11967.1 - 5.7e-33 113.0 0.0 1.1e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Methyltransf_32 PF13679.1 ESL11968.1 - 5e-15 55.4 0.1 1.2e-07 31.5 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain DUF2423 PF10338.4 ESL11969.1 - 0.00035 20.4 4.7 0.0011 18.8 3.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) DUF4429 PF14472.1 ESL11969.1 - 0.056 13.7 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4429) zf-B_box PF00643.19 ESL11970.1 - 4e-08 33.0 32.9 7.9e-06 25.6 7.6 3.7 3 0 0 3 3 3 2 B-box zinc finger zf-C3HC4_4 PF15227.1 ESL11970.1 - 3.1e-07 30.1 7.6 3.1e-07 30.1 5.3 3.8 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 ESL11970.1 - 3.8e-07 29.6 5.2 3.8e-07 29.6 3.6 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL11970.1 - 1.6e-05 24.8 5.7 1.6e-05 24.8 4.0 3.7 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESL11970.1 - 0.00017 21.2 6.9 0.00017 21.2 4.8 3.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESL11970.1 - 0.0004 20.1 5.9 0.0004 20.1 4.1 3.6 3 0 0 3 3 3 1 Ring finger domain IBR PF01485.16 ESL11970.1 - 0.0028 17.4 3.4 0.0028 17.4 2.3 3.9 4 0 0 4 4 4 1 IBR domain Mod_r PF07200.8 ESL11971.1 - 6.9e-12 45.5 3.8 1.2e-11 44.7 2.6 1.4 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein AKNA PF12443.3 ESL11971.1 - 0.0027 17.6 2.3 0.0056 16.6 0.6 2.1 1 1 1 2 2 2 1 AT-hook-containing transcription factor GAS PF13851.1 ESL11971.1 - 0.0088 15.2 8.0 0.025 13.7 5.6 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.6 ESL11971.1 - 0.031 14.1 2.3 0.16 11.8 1.9 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Syntaxin PF00804.20 ESL11971.1 - 0.064 13.4 1.4 0.17 12.0 1.0 1.7 1 0 0 1 1 1 0 Syntaxin MCPsignal PF00015.16 ESL11971.1 - 0.064 12.7 0.1 0.11 11.9 0.1 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DASH_Dad1 PF08649.5 ESL11971.1 - 0.067 12.9 0.5 3.2 7.5 0.0 3.0 3 0 0 3 3 3 0 DASH complex subunit Dad1 Baculo_PEP_C PF04513.7 ESL11971.1 - 0.081 12.7 1.1 0.14 11.9 0.2 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC PF04632.7 ESL11971.1 - 0.093 11.1 3.4 0.14 10.5 2.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family HAMP PF00672.20 ESL11971.1 - 0.18 11.9 0.4 0.18 11.9 0.3 1.8 2 0 0 2 2 2 0 HAMP domain DASH_Dam1 PF08653.5 ESL11971.1 - 0.26 11.0 1.4 5.1 6.9 0.1 3.2 4 0 0 4 4 4 0 DASH complex subunit Dam1 TMF_DNA_bd PF12329.3 ESL11971.1 - 0.6 9.9 5.1 0.61 9.9 1.8 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Apolipoprotein PF01442.13 ESL11971.1 - 1.4 8.4 12.1 5.9 6.3 6.9 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Cep57_MT_bd PF06657.8 ESL11971.1 - 2 8.4 6.5 1.6 8.7 1.8 2.2 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF972 PF06156.8 ESL11971.1 - 3.6 7.9 5.0 3.4 8.0 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) TPM PF04536.9 ESL11972.1 - 9.7e-14 51.2 0.0 1.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase DUF4543 PF15076.1 ESL11972.1 - 0.056 13.4 0.1 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) zf-IS66 PF13005.2 ESL11972.1 - 0.48 10.4 0.1 0.48 10.4 0.1 3.1 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 DUF2387 PF09526.5 ESL11972.1 - 1.2 9.0 6.6 2 8.3 2.8 2.3 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Cytochrome_C7 PF14522.1 ESL11972.1 - 3.1 7.4 11.9 2.9 7.5 2.0 2.2 1 1 1 2 2 2 0 Cytochrome c7 Mut7-C PF01927.11 ESL11972.1 - 5.1 7.0 11.3 2 8.3 0.7 2.3 2 0 0 2 2 2 0 Mut7-C RNAse domain Fer4_10 PF13237.1 ESL11972.1 - 7.7 6.3 9.9 1 9.2 2.4 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Choline_kinase PF01633.15 ESL11973.1 - 1.1e-11 44.7 0.0 2.2e-11 43.7 0.0 1.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 ESL11973.1 - 0.00096 18.9 0.0 0.0028 17.4 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Peptidase_S28 PF05577.7 ESL11974.1 - 2.7e-60 204.1 1.3 6.6e-60 202.9 0.9 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.6 ESL11974.1 - 4.5e-07 28.7 0.1 6.7e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.16 ESL11974.1 - 8e-06 25.2 0.2 1.4e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 ESL11974.1 - 7.8e-05 22.6 1.1 7.8e-05 22.6 0.7 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL11974.1 - 0.001 18.6 0.1 0.0015 18.1 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 ESL11974.1 - 0.048 13.0 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative esterase PHO4 PF01384.15 ESL11975.1 - 1.4e-105 352.6 25.6 1.4e-105 352.6 17.7 1.6 2 0 0 2 2 2 1 Phosphate transporter family Myco_arth_vir_N PF09610.5 ESL11975.1 - 0.1 12.5 0.4 0.77 9.7 0.0 2.8 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Dimer_Tnp_hAT PF05699.9 ESL11975.1 - 0.24 11.0 1.3 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region CLPTM1 PF05602.7 ESL11979.1 - 4.4e-109 365.1 0.0 5.6e-109 364.7 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.9 ESL11979.1 - 0.061 12.8 2.6 0.13 11.8 0.1 2.4 2 0 0 2 2 2 0 PQ loop repeat Pkinase PF00069.20 ESL11980.1 - 1.6e-60 204.4 0.0 2.6e-60 203.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL11980.1 - 3.1e-41 141.1 0.0 5.3e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.24 ESL11980.1 - 1.2e-11 44.2 0.1 7.9e-05 22.3 0.0 2.8 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Kinase-like PF14531.1 ESL11980.1 - 1.9e-10 40.1 0.0 6.4e-09 35.1 0.0 2.3 1 1 1 2 2 2 1 Kinase-like PAS PF00989.19 ESL11980.1 - 1.6e-06 27.9 0.0 5.9e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 ESL11980.1 - 0.0017 18.6 0.0 0.0056 17.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain Actin PF00022.14 ESL11981.1 - 5.3e-44 150.2 0.0 7.8e-44 149.6 0.0 1.2 1 1 0 1 1 1 1 Actin RNase_T PF00929.19 ESL11982.1 - 0.0022 18.3 0.0 0.0044 17.3 0.0 1.4 2 0 0 2 2 2 1 Exonuclease SPT16 PF08644.6 ESL11983.1 - 1.6e-36 125.4 1.8 1.6e-36 125.4 0.1 1.9 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.19 ESL11983.1 - 7.5e-16 58.3 0.0 1.5e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 ESL11983.1 - 9.7e-14 51.1 0.0 3.6e-13 49.2 0.0 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like TFIIA PF03153.8 ESL11983.1 - 0.00065 19.7 4.9 0.0011 18.9 3.4 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 ESL11983.1 - 4.8 4.9 21.4 12 3.6 14.8 1.5 1 0 0 1 1 1 0 Nop14-like family Ank_2 PF12796.2 ESL11986.1 - 9.1e-20 70.8 0.0 5.9e-16 58.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESL11986.1 - 2.9e-15 55.2 0.0 1.1e-05 24.9 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 ESL11986.1 - 3.6e-11 43.2 0.0 3.8e-07 30.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL11986.1 - 5.2e-10 38.5 0.0 0.0013 18.7 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 ESL11986.1 - 5.9e-10 39.0 0.1 1.9e-06 27.8 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ribosomal_L39 PF00832.15 ESL11987.1 - 1.1e-19 69.5 13.5 1.2e-19 69.4 9.4 1.0 1 0 0 1 1 1 1 Ribosomal L39 protein Methyltransf_FA PF12248.3 ESL11987.1 - 0.019 14.9 0.0 0.021 14.8 0.0 1.1 1 0 0 1 1 1 0 Farnesoic acid 0-methyl transferase SGL PF08450.7 ESL11988.1 - 6.9e-11 41.9 0.0 2.6e-08 33.5 0.0 2.0 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.16 ESL11988.1 - 1.1e-06 28.2 2.7 0.079 12.9 0.0 5.7 6 0 0 6 6 6 2 NHL repeat Str_synth PF03088.11 ESL11988.1 - 0.0015 18.4 0.0 0.43 10.6 0.0 2.8 2 1 0 2 2 2 2 Strictosidine synthase Lactonase PF10282.4 ESL11988.1 - 0.01 14.9 0.0 0.95 8.4 0.0 3.0 1 1 3 4 4 4 0 Lactonase, 7-bladed beta-propeller GSDH PF07995.6 ESL11988.1 - 0.17 10.9 0.0 0.64 9.0 0.0 1.9 1 1 0 1 1 1 0 Glucose / Sorbosone dehydrogenase HSP90 PF00183.13 ESL11989.1 - 2.8e-262 870.8 32.5 3.3e-262 870.6 22.5 1.0 1 0 0 1 1 1 1 Hsp90 protein DUF1510 PF07423.6 ESL11989.1 - 0.0083 15.5 12.6 0.0083 15.5 8.8 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) HATPase_c PF02518.21 ESL11989.1 - 0.019 14.6 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.4 ESL11989.1 - 0.025 14.3 0.4 0.074 12.8 0.3 1.8 1 0 0 1 1 1 0 Tumour suppressor protein Y_phosphatase2 PF03162.8 ESL11990.1 - 2.5e-22 78.9 0.0 3.7e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family UPF0160 PF03690.8 ESL11991.1 - 1.4e-123 412.3 0.0 1.6e-123 412.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) AMP-binding PF00501.23 ESL11992.1 - 6.2e-28 97.3 0.0 7e-25 87.2 0.0 2.8 2 1 0 2 2 2 2 AMP-binding enzyme ABC1 PF03109.11 ESL11993.1 - 7.3e-28 96.9 0.0 1.5e-27 95.8 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 ESL11993.1 - 3.7e-07 30.1 0.3 3.7e-07 30.1 0.2 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESL11993.1 - 4.3e-06 26.0 0.3 0.064 12.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ESL11993.1 - 7e-05 22.2 0.1 0.00014 21.2 0.0 1.5 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.12 ESL11993.1 - 7.5e-05 21.9 0.0 0.041 12.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESL11993.1 - 0.079 12.0 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ATP-synt_ab PF00006.20 ESL11994.1 - 2.2e-61 207.1 0.0 2.8e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL11994.1 - 2.8e-14 53.5 0.1 5.7e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESL11994.1 - 2.3e-13 50.1 0.8 4.6e-13 49.1 0.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain STOP PF05217.7 ESL11995.1 - 3e-10 40.2 15.7 2.1e-06 27.6 9.3 3.8 2 1 1 3 3 3 3 STOP protein DAO PF01266.19 ESL11996.1 - 4.4e-29 101.5 0.7 6.2e-29 101.0 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESL11996.1 - 5.2e-06 25.5 0.8 5.2e-06 25.5 0.5 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 ESL11996.1 - 9.6e-06 24.3 0.4 1.4e-05 23.8 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.2 ESL11996.1 - 1e-05 24.8 1.9 1.6e-05 24.1 1.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESL11996.1 - 6.2e-05 22.9 0.5 0.00019 21.4 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESL11996.1 - 7.1e-05 22.7 0.2 0.0002 21.3 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESL11996.1 - 0.0051 15.9 0.1 0.0086 15.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 ESL11996.1 - 0.013 14.4 1.0 0.013 14.4 0.7 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.12 ESL11996.1 - 0.013 14.5 0.2 0.025 13.7 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.7 ESL11996.1 - 0.022 13.6 0.9 0.039 12.8 0.7 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.1 ESL11996.1 - 0.033 14.2 0.3 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESL11996.1 - 0.035 14.5 0.1 0.084 13.2 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 ESL11996.1 - 0.79 9.3 3.1 0.41 10.2 0.6 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Myosin_head PF00063.16 ESL11997.1 - 5.5e-161 537.0 0.0 8.5e-161 536.3 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.22 ESL11997.1 - 2.2e-05 23.6 10.8 0.0062 16.0 2.3 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_16 PF13191.1 ESL11997.1 - 0.0085 16.0 0.6 0.054 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESL11997.1 - 0.024 14.7 0.3 0.092 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ESL11997.1 - 0.14 12.9 0.2 0.14 12.9 0.1 3.1 2 1 0 2 2 2 0 AAA domain Ribosomal_L34e PF01199.13 ESL11998.1 - 2.6e-29 101.2 4.6 2.6e-29 101.2 3.2 2.4 2 1 0 2 2 2 1 Ribosomal protein L34e DUF2762 PF10960.3 ESL11998.1 - 7.7 6.3 7.5 14 5.4 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) CBF PF03914.12 ESL11999.1 - 4.5e-34 117.2 0.2 1.3e-33 115.7 0.0 1.8 2 0 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.6 ESL11999.1 - 0.044 14.0 0.0 0.044 14.0 0.0 3.0 3 1 0 3 3 3 0 Nucleolar complex-associated protein DAG1 PF05454.6 ESL11999.1 - 0.061 12.4 0.8 0.1 11.7 0.6 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) ABC_membrane_2 PF06472.10 ESL12001.1 - 6.4e-55 186.2 3.0 8.9e-55 185.7 2.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESL12001.1 - 2.1e-15 57.2 0.0 3.5e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESL12001.1 - 7.2e-05 22.1 0.1 0.15 11.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 ESL12001.1 - 0.00037 20.5 0.0 0.003 17.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.1 ESL12001.1 - 0.028 13.9 0.0 0.39 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESL12001.1 - 0.037 13.5 0.0 0.09 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.8 ESL12001.1 - 0.082 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.9 ESL12001.1 - 0.085 12.5 0.1 0.21 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF258 PF03193.11 ESL12001.1 - 0.11 11.6 0.0 0.24 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESL12001.1 - 0.13 11.6 0.1 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.24 ESL12001.1 - 0.16 12.1 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESL12001.1 - 0.2 10.3 0.1 0.37 9.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_23 PF13476.1 ESL12001.1 - 0.23 11.7 0.0 0.45 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 ESL12001.1 - 0.24 11.3 0.0 0.81 9.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain UDPGP PF01704.13 ESL12002.1 - 2.5e-89 299.7 0.0 3.2e-89 299.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Ufd2P_core PF10408.4 ESL12003.1 - 8.2e-126 420.7 0.0 1e-125 420.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core Thioredoxin PF00085.15 ESL12003.1 - 4.2e-19 68.1 0.0 1e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESL12003.1 - 0.00093 19.2 0.0 0.0027 17.7 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 ESL12003.1 - 0.025 14.2 0.1 0.055 13.1 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family U-box PF04564.10 ESL12003.1 - 0.042 13.8 0.6 0.21 11.5 0.4 2.2 1 1 0 1 1 1 0 U-box domain Redoxin PF08534.5 ESL12003.1 - 0.059 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.1 ESL12003.1 - 0.067 13.2 0.6 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_2 PF13098.1 ESL12003.1 - 0.071 13.3 0.1 0.2 11.8 0.1 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain Glycolytic PF00274.14 ESL12004.1 - 2.1e-148 493.4 0.0 2.3e-148 493.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I eIF-3_zeta PF05091.7 ESL12004.1 - 0.15 10.6 0.1 0.21 10.1 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Aldose_epim PF01263.15 ESL12005.1 - 3.2e-38 131.5 0.2 4e-38 131.2 0.1 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase AAA_25 PF13481.1 ESL12006.1 - 0.0033 16.8 0.1 0.0093 15.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain Rad51 PF08423.6 ESL12006.1 - 0.0043 15.9 0.5 0.012 14.5 0.4 1.7 1 1 0 1 1 1 1 Rad51 KaiC PF06745.8 ESL12006.1 - 0.0044 16.1 0.0 0.0072 15.4 0.0 1.3 1 0 0 1 1 1 1 KaiC RecA PF00154.16 ESL12006.1 - 0.035 13.1 0.0 0.05 12.6 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein NACHT PF05729.7 ESL12006.1 - 0.092 12.4 0.3 0.31 10.6 0.0 1.9 2 1 0 2 2 2 0 NACHT domain Methyltransf_5 PF01795.14 ESL12006.1 - 0.1 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family Med9 PF07544.8 ESL12007.1 - 0.0042 16.7 1.4 0.0042 16.7 1.0 2.1 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Histone_HNS PF00816.16 ESL12007.1 - 0.0078 16.6 0.4 0.53 10.8 0.4 2.2 2 0 0 2 2 2 1 H-NS histone family DUF3020 PF11223.3 ESL12007.1 - 0.48 10.8 4.6 0.93 9.9 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3020) DUF4355 PF14265.1 ESL12007.1 - 1.4 8.8 6.1 2.3 8.2 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Peptidase_S49_N PF08496.5 ESL12007.1 - 2.9 7.6 5.1 0.38 10.5 1.0 1.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CRAL_TRIO PF00650.15 ESL12008.1 - 0.005 16.3 0.0 0.0069 15.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Thioredoxin_8 PF13905.1 ESL12009.1 - 1.1e-15 57.5 0.1 1.6e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 ESL12009.1 - 1.8e-05 24.3 0.0 2.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESL12009.1 - 0.0024 17.4 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin ECH PF00378.15 ESL12010.1 - 1.4e-54 184.8 0.0 1.8e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ATP-synt_C PF00137.16 ESL12012.1 - 4.3e-25 87.4 27.0 6.6e-18 64.3 7.1 3.1 3 0 0 3 3 3 2 ATP synthase subunit C TF_Otx PF03529.8 ESL12012.1 - 0.039 14.1 0.4 0.076 13.2 0.3 1.5 1 0 0 1 1 1 0 Otx1 transcription factor GerA PF03323.8 ESL12012.1 - 0.17 10.0 3.9 1.6 6.7 0.3 2.2 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Flavi_NS4A PF01350.12 ESL12012.1 - 1.2 8.7 4.9 13 5.3 0.9 2.3 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4A CDC45 PF02724.9 ESL12014.1 - 1.6e-125 419.5 0.0 1.9e-125 419.3 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF1168 PF06658.7 ESL12014.1 - 0.0025 17.3 1.2 0.0052 16.3 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Nop53 PF07767.6 ESL12014.1 - 0.083 11.8 5.4 0.3 10.0 3.9 1.7 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) REV PF00424.13 ESL12014.1 - 0.36 10.7 7.7 0.047 13.5 2.3 1.8 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) ABC1 PF03109.11 ESL12016.1 - 3.3e-26 91.6 0.0 8.6e-26 90.2 0.0 1.8 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 ESL12016.1 - 0.0093 15.7 0.5 0.09 12.4 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family MutS_V PF00488.16 ESL12018.1 - 1.7e-84 282.9 0.1 2.9e-84 282.1 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESL12018.1 - 5.5e-32 111.2 2.1 1.5e-31 109.7 1.4 1.8 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 ESL12018.1 - 6.7e-20 71.0 3.0 1.9e-19 69.6 2.1 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.1 ESL12018.1 - 0.094 12.2 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Aa_trans PF01490.13 ESL12019.1 - 9.9e-50 169.2 33.8 1.3e-49 168.8 23.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESL12019.1 - 5.6e-10 38.5 18.6 1.2e-09 37.4 12.9 1.4 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESL12019.1 - 5.4e-08 31.7 22.0 5.4e-08 31.7 15.3 2.2 2 0 0 2 2 2 1 Amino acid permease IF-2B PF01008.12 ESL12020.1 - 6.4e-19 68.0 3.8 1.2e-16 60.5 2.7 3.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family Porin_3 PF01459.17 ESL12021.1 - 0.0041 16.4 0.0 0.0083 15.4 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic porin PKD_channel PF08016.7 ESL12022.1 - 5.4e-05 21.8 10.4 0.00015 20.3 7.2 1.7 1 0 0 1 1 1 1 Polycystin cation channel MotB_plug PF13677.1 ESL12022.1 - 2 7.8 9.2 39 3.6 4.7 2.9 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB RRM_1 PF00076.17 ESL12023.1 - 2.9e-17 62.0 0.0 4.2e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL12023.1 - 2e-13 50.1 0.0 3e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL12023.1 - 7.1e-08 32.1 0.0 9.9e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 2OG-FeII_Oxy_4 PF13661.1 ESL12024.1 - 0.29 10.7 2.6 0.16 11.6 0.2 1.7 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily ATP-gua_Ptrans PF00217.14 ESL12025.1 - 7.5e-109 362.7 0.0 8.6e-109 362.5 0.0 1.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.10 ESL12025.1 - 3.3e-22 78.4 0.2 8.4e-22 77.1 0.0 1.8 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, N-terminal domain DUF1342 PF07072.6 ESL12025.1 - 0.025 14.2 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) DUF947 PF06102.7 ESL12026.1 - 1.5e-16 60.6 13.3 4.7e-16 59.0 9.2 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF947) DUF1660 PF07874.6 ESL12026.1 - 0.042 14.1 0.3 0.095 12.9 0.2 1.6 1 0 0 1 1 1 0 Prophage protein (DUF1660) PIG-U PF06728.8 ESL12027.1 - 5.1e-05 22.3 13.2 0.0026 16.6 9.1 2.4 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U zf-RING_2 PF13639.1 ESL12028.1 - 1.3e-07 31.3 2.6 1.3e-07 31.3 1.8 3.8 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.20 ESL12028.1 - 1e-05 25.0 0.8 1e-05 25.0 0.6 3.6 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESL12028.1 - 0.00065 19.6 4.2 0.00065 19.6 2.9 4.2 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESL12028.1 - 0.025 14.4 0.3 0.025 14.4 0.2 4.1 4 1 1 5 5 5 0 zinc finger of C3HC4-type, RING zf-CSL PF05207.8 ESL12028.1 - 8.2 6.0 20.1 2.1 7.9 6.0 3.7 3 2 0 3 3 3 0 CSL zinc finger Ribosomal_L38e PF01781.13 ESL12029.1 - 8.4e-30 102.3 4.3 1.2e-29 101.8 3.0 1.2 1 0 0 1 1 1 1 Ribosomal L38e protein family DUF2359 PF10151.4 ESL12029.1 - 0.006 15.1 0.1 0.0065 15.0 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2359) TrbM PF07424.6 ESL12029.1 - 0.17 11.8 1.1 0.2 11.6 0.8 1.1 1 0 0 1 1 1 0 TrbM Synthase_beta PF11421.3 ESL12030.1 - 0.26 11.9 2.2 0.59 10.8 1.6 1.6 1 0 0 1 1 1 0 ATP synthase F1 beta subunit Methyltransf_30 PF05430.6 ESL12031.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_31 PF13847.1 ESL12031.1 - 0.031 13.8 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 ESL12031.1 - 0.077 12.7 0.0 0.15 11.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain TPR_12 PF13424.1 ESL12033.1 - 0.00019 21.3 2.4 0.0049 16.7 0.8 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESL12033.1 - 0.00028 20.4 0.2 0.27 10.9 0.0 3.2 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 ESL12033.1 - 0.0013 18.4 4.5 0.8 9.7 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESL12033.1 - 0.0027 17.9 1.5 0.25 11.6 0.4 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESL12033.1 - 0.0055 16.4 0.7 0.39 10.6 0.0 3.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESL12033.1 - 0.012 16.1 0.5 26 5.8 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat UNC45-central PF11701.3 ESL12033.1 - 0.02 14.5 0.0 0.17 11.5 0.0 2.3 1 1 1 2 2 2 0 Myosin-binding striated muscle assembly central TPR_1 PF00515.23 ESL12033.1 - 0.11 12.0 4.1 6.7 6.4 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESL12033.1 - 0.12 12.8 2.3 14 6.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL12034.1 - 2.9e-20 72.5 0.0 1.3e-19 70.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL12034.1 - 3.5e-12 45.9 0.0 1.6e-11 43.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL12034.1 - 0.014 14.4 0.0 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like F420_oxidored PF03807.12 ESL12035.1 - 2.3e-06 27.9 0.0 5.7e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 ESL12035.1 - 2.4e-05 24.2 0.1 6.8e-05 22.8 0.1 1.8 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.1 ESL12035.1 - 0.016 15.4 0.1 0.069 13.4 0.0 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_10 PF13460.1 ESL12035.1 - 0.036 14.0 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding Shikimate_DH PF01488.15 ESL12035.1 - 0.04 14.0 0.0 0.092 12.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TPR_12 PF13424.1 ESL12035.1 - 0.044 13.7 0.1 0.14 12.1 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Saccharop_dh PF03435.13 ESL12035.1 - 0.12 11.2 0.2 0.25 10.2 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase ThiF PF00899.16 ESL12036.1 - 1.4e-49 167.3 1.9 1.6e-32 112.1 0.0 2.4 2 0 0 2 2 2 2 ThiF family UBACT PF02134.16 ESL12036.1 - 1e-32 111.5 0.0 1.1e-21 76.1 0.0 3.1 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_C PF09358.5 ESL12036.1 - 1.4e-26 93.1 0.0 2.7e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBA_e1_thiolCys PF10585.4 ESL12036.1 - 2e-20 71.9 1.2 2e-20 71.9 0.8 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 ESL12036.1 - 0.046 13.8 0.3 13 5.8 0.0 2.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PPR PF01535.15 ESL12039.1 - 6.9e-05 22.5 1.9 0.00087 19.1 0.1 2.6 2 0 0 2 2 2 1 PPR repeat PPR_2 PF13041.1 ESL12039.1 - 0.0002 21.2 0.6 0.0011 18.9 0.1 2.2 1 1 1 2 2 2 1 PPR repeat family Apc3 PF12895.2 ESL12039.1 - 0.1 12.7 0.1 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 VID27 PF08553.5 ESL12041.1 - 0.0064 14.7 0.0 0.0066 14.7 0.0 1.1 1 0 0 1 1 1 1 VID27 cytoplasmic protein Fer4_7 PF12838.2 ESL12041.1 - 0.085 13.2 0.5 0.15 12.4 0.4 1.6 1 1 0 1 1 1 0 4Fe-4S dicluster domain Reo_sigmaC PF04582.7 ESL12042.1 - 0.00074 18.7 10.1 0.038 13.1 2.8 2.3 1 1 1 2 2 2 2 Reovirus sigma C capsid protein DUF904 PF06005.7 ESL12042.1 - 0.0022 18.2 22.2 0.22 11.8 3.7 4.0 3 1 1 4 4 4 2 Protein of unknown function (DUF904) CENP-F_leu_zip PF10473.4 ESL12042.1 - 0.013 15.3 26.6 0.077 12.8 4.7 3.5 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Gp58 PF07902.6 ESL12042.1 - 0.041 12.0 11.7 0.12 10.5 8.1 1.6 1 1 0 1 1 1 0 gp58-like protein DUF4407 PF14362.1 ESL12042.1 - 0.22 10.4 17.0 0.042 12.8 5.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ATG16 PF08614.6 ESL12042.1 - 0.29 10.9 24.1 1.6 8.4 9.1 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) IncA PF04156.9 ESL12042.1 - 0.3 10.6 33.2 1.1 8.8 5.6 3.3 1 1 3 4 4 4 0 IncA protein Baculo_PEP_C PF04513.7 ESL12042.1 - 0.87 9.4 6.3 2.4 7.9 0.1 2.7 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.6 ESL12042.1 - 0.87 8.1 22.2 0.41 9.2 8.3 2.4 1 1 2 3 3 3 0 Spc7 kinetochore protein Med9 PF07544.8 ESL12042.1 - 0.94 9.2 14.1 5.2 6.8 0.5 4.5 2 1 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF948 PF06103.6 ESL12042.1 - 1.6 8.6 3.8 23 4.9 0.3 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GvpK PF05121.7 ESL12042.1 - 2.7 7.8 7.1 1.1 9.1 0.1 3.1 3 1 0 3 3 3 0 Gas vesicle protein K SlyX PF04102.7 ESL12042.1 - 5.8 7.3 15.1 22 5.4 0.3 4.1 2 1 1 4 4 4 0 SlyX KxDL PF10241.4 ESL12042.1 - 7.4 6.5 14.2 2.3 8.1 1.6 3.8 1 1 3 4 4 4 0 Uncharacterized conserved protein DUF16 PF01519.11 ESL12042.1 - 7.6 6.8 12.6 2.4 8.4 3.2 3.0 1 1 2 3 3 3 0 Protein of unknown function DUF16 APG6 PF04111.7 ESL12042.1 - 8.3 5.3 23.0 0.24 10.4 5.0 2.4 1 1 2 3 3 3 0 Autophagy protein Apg6 Vac14_Fig4_bd PF11916.3 ESL12044.1 - 2.8e-56 189.5 1.9 2.8e-56 189.5 1.3 2.4 3 0 0 3 3 3 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 ESL12044.1 - 4.7e-07 30.0 0.1 2.6e-05 24.5 0.0 2.8 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.17 ESL12044.1 - 0.019 14.9 3.8 9.2 6.6 0.1 4.5 4 0 0 4 4 4 0 HEAT repeat RIX1 PF08167.7 ESL12044.1 - 0.16 11.6 3.4 0.33 10.6 0.1 3.1 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis Methyltransf_26 PF13659.1 ESL12045.1 - 1.4e-17 63.7 0.0 2.4e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESL12045.1 - 5.9e-07 29.0 0.0 0.00052 19.4 0.0 3.1 2 1 0 2 2 2 2 Methyltransferase small domain Methyltransf_31 PF13847.1 ESL12045.1 - 0.0011 18.5 0.0 0.006 16.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESL12045.1 - 0.0017 18.9 0.1 0.025 15.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESL12045.1 - 0.0025 17.5 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESL12045.1 - 0.0086 16.4 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESL12045.1 - 0.015 14.3 0.0 2.3 7.2 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase HMG-CoA_red PF00368.13 ESL12048.1 - 1.3e-154 514.3 0.7 1.5e-154 514.1 0.5 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase ATG16 PF08614.6 ESL12049.1 - 2.2e-05 24.3 2.4 3.1e-05 23.8 1.7 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 ESL12049.1 - 0.31 10.1 6.4 0.7 9.0 4.1 1.7 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TMPIT PF07851.8 ESL12049.1 - 0.37 9.8 2.6 0.49 9.4 1.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF3677 PF12432.3 ESL12049.1 - 1.1 9.7 3.3 7.4 7.0 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3677) ATPgrasp_YheCD PF14398.1 ESL12050.1 - 0.0061 15.3 0.0 0.0089 14.8 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp WD40 PF00400.27 ESL12051.1 - 0.00027 20.6 0.1 6.4 6.8 0.0 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF2415 PF10313.4 ESL12051.1 - 0.13 11.9 0.0 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) Pkinase PF00069.20 ESL12052.1 - 1.4e-51 175.1 0.0 2e-51 174.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL12052.1 - 6.6e-29 100.7 0.0 9.2e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.1 ESL12052.1 - 3.5e-12 46.2 0.8 0.00015 21.7 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL12052.1 - 3.8e-10 39.2 5.0 2.9e-05 23.5 0.2 3.4 3 1 1 4 4 4 2 EF-hand domain pair Kinase-like PF14531.1 ESL12052.1 - 8.7e-09 34.7 0.0 1.3e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like EF-hand_6 PF13405.1 ESL12052.1 - 9.9e-06 25.0 10.6 0.88 9.6 0.0 5.1 5 0 0 5 5 5 3 EF-hand domain EF-hand_1 PF00036.27 ESL12052.1 - 2.4e-05 23.3 8.3 1.7 8.1 0.0 5.5 5 1 0 5 5 5 2 EF hand Kdo PF06293.9 ESL12052.1 - 0.0071 15.4 0.0 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.4 ESL12052.1 - 0.025 14.6 0.1 0.71 9.9 0.2 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4500 PF14937.1 ESL12052.1 - 0.058 13.2 0.2 0.41 10.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) Choline_kinase PF01633.15 ESL12052.1 - 0.089 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 ESL12052.1 - 0.093 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CGI-121 PF08617.5 ESL12053.1 - 1.4e-09 37.8 0.0 3.2e-09 36.6 0.0 1.5 1 1 0 1 1 1 1 Kinase binding protein CGI-121 Torsin PF06309.6 ESL12054.1 - 3.1e-06 27.0 0.0 6.6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Torsin RuvB_N PF05496.7 ESL12054.1 - 0.00075 18.6 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_23 PF13476.1 ESL12054.1 - 0.0036 17.6 0.0 0.0063 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL12054.1 - 0.0049 16.5 0.0 0.016 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.7 ESL12054.1 - 0.022 14.4 0.0 0.067 12.8 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 ESL12054.1 - 0.028 14.7 0.0 0.08 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 ESL12054.1 - 0.033 14.1 0.2 0.3 11.0 0.0 2.3 2 1 0 3 3 3 0 AAA domain AAA_16 PF13191.1 ESL12054.1 - 0.039 13.9 0.1 0.12 12.3 0.0 1.9 1 1 1 2 2 2 0 AAA ATPase domain APS_kinase PF01583.15 ESL12054.1 - 0.048 13.3 0.0 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 Adenylylsulphate kinase Sigma54_activ_2 PF14532.1 ESL12054.1 - 0.062 13.3 0.0 0.53 10.3 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.17 ESL12054.1 - 0.065 12.0 0.0 0.14 10.9 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.24 ESL12054.1 - 0.077 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL12054.1 - 0.078 13.7 0.0 0.19 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESL12054.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA PF00004.24 ESL12055.1 - 1.3e-15 57.7 0.0 2.9e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL12055.1 - 1.5e-07 31.5 0.0 3.4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESL12055.1 - 1.4e-05 24.8 0.0 3e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESL12055.1 - 2.9e-05 24.8 0.0 0.00012 22.9 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.1 ESL12055.1 - 6e-05 23.1 0.0 0.00026 21.1 0.0 2.1 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.1 ESL12055.1 - 0.00012 21.7 0.1 0.00032 20.3 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 ESL12055.1 - 0.00077 18.6 0.0 0.0019 17.2 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 ESL12055.1 - 0.00085 19.2 0.0 0.002 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESL12055.1 - 0.0013 19.0 0.1 0.0054 17.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 ESL12055.1 - 0.0014 18.3 0.0 0.0051 16.4 0.0 2.0 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.17 ESL12055.1 - 0.0015 18.6 0.0 0.0032 17.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase UPF0079 PF02367.12 ESL12055.1 - 0.0018 17.8 0.0 0.0041 16.7 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 ESL12055.1 - 0.0029 17.5 0.9 0.009 15.9 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESL12055.1 - 0.0035 16.7 0.0 0.0075 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESL12055.1 - 0.0044 16.0 0.0 0.01 14.9 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESL12055.1 - 0.0046 16.8 0.0 0.013 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESL12055.1 - 0.005 16.2 0.0 0.0096 15.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_23 PF13476.1 ESL12055.1 - 0.0068 16.7 0.4 0.083 13.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.1 ESL12055.1 - 0.0071 15.9 0.3 0.015 14.8 0.0 1.7 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.8 ESL12055.1 - 0.0079 15.1 0.0 0.015 14.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_30 PF13604.1 ESL12055.1 - 0.039 13.5 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESL12055.1 - 0.043 13.5 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 Archaeal ATPase TIP49 PF06068.8 ESL12055.1 - 0.046 12.4 0.0 0.08 11.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 ESL12055.1 - 0.051 13.1 0.3 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESL12055.1 - 0.052 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Rad17 PF03215.10 ESL12055.1 - 0.075 11.6 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein KaiC PF06745.8 ESL12055.1 - 0.1 11.6 0.0 0.24 10.5 0.0 1.5 1 0 0 1 1 1 0 KaiC cobW PF02492.14 ESL12055.1 - 0.1 12.0 0.2 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.16 ESL12055.1 - 0.12 11.5 0.1 0.24 10.5 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF1129 PF06570.6 ESL12056.1 - 0.089 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Ax_dynein_light PF10211.4 ESL12056.1 - 7.9 6.2 26.4 0.026 14.3 2.1 3.4 2 2 1 3 3 3 0 Axonemal dynein light chain Rad51 PF08423.6 ESL12057.1 - 1e-134 447.2 0.9 2e-134 446.3 0.4 1.6 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 ESL12057.1 - 3.9e-14 52.4 0.0 6.1e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 ESL12057.1 - 9.6e-09 35.2 0.1 2.3e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.16 ESL12057.1 - 1.8e-08 33.8 0.2 3e-08 33.0 0.2 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 ESL12057.1 - 9.2e-05 21.6 0.2 0.00022 20.4 0.1 1.7 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.1 ESL12057.1 - 0.0061 16.7 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.10 ESL12057.1 - 0.051 12.4 0.0 0.094 11.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain FLO_LFY PF01698.11 ESL12057.1 - 0.056 12.2 0.3 1.2 7.9 0.0 2.4 3 0 0 3 3 3 0 Floricaula / Leafy protein IFT46_B_C PF12317.3 ESL12058.1 - 1.6e-91 305.4 0.2 2.3e-91 304.9 0.1 1.2 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal DEAD PF00270.24 ESL12059.1 - 1.7e-32 112.2 0.1 2.8e-32 111.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL12059.1 - 4.5e-20 71.2 0.0 1e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESL12059.1 - 3e-12 45.8 5.4 3.1e-12 45.8 0.4 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESL12059.1 - 0.00013 21.9 0.0 0.00046 20.0 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 ESL12059.1 - 0.032 13.3 0.0 0.073 12.1 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.1 ESL12059.1 - 0.21 11.7 3.0 2.3 8.3 0.5 3.2 2 1 0 2 2 2 0 AAA domain DSPc PF00782.15 ESL12060.1 - 4.8e-08 32.6 0.0 5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESL12060.1 - 8.9e-06 25.2 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase YniB PF14002.1 ESL12061.1 - 0.053 12.9 0.1 0.063 12.7 0.0 1.1 1 0 0 1 1 1 0 YniB-like protein Mt_ATP-synt_B PF05405.9 ESL12061.1 - 0.082 12.3 0.2 0.11 11.9 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) MutS_V PF00488.16 ESL12062.1 - 2.2e-65 220.3 0.0 3.2e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESL12062.1 - 8.2e-25 87.7 0.8 1.4e-24 87.0 0.6 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 ESL12062.1 - 1.3e-06 28.4 0.0 3.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV DUF3995 PF13160.1 ESL12063.1 - 0.051 13.6 0.7 0.072 13.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3995) LMWPc PF01451.16 ESL12064.1 - 3.6e-09 37.0 0.1 7.8e-09 35.9 0.0 1.6 2 0 0 2 2 2 1 Low molecular weight phosphotyrosine protein phosphatase Leu_leader PF08054.6 ESL12064.1 - 0.012 15.2 0.7 0.034 13.7 0.5 1.8 1 0 0 1 1 1 0 Leucine operon leader peptide PEPCK_ATP PF01293.15 ESL12065.1 - 5.1e-156 519.8 0.0 6e-156 519.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 ESL12065.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESL12065.1 - 0.04 13.8 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.1 ESL12065.1 - 0.073 12.4 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESL12065.1 - 0.13 11.8 0.1 0.29 10.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1469 PF07332.6 ESL12066.1 - 3.9 7.2 7.8 0.21 11.3 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) ChaC PF04752.7 ESL12067.1 - 1e-45 155.8 0.0 1.1e-45 155.7 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein DEAD PF00270.24 ESL12069.1 - 3.7e-24 85.1 0.1 9e-24 83.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESL12069.1 - 4.3e-07 29.6 0.0 1.2e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESL12069.1 - 5.5e-05 23.0 0.0 9.4e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 ESL12069.1 - 0.015 14.7 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ESL12069.1 - 0.02 14.1 0.0 0.044 12.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein SecA_DEAD PF07517.9 ESL12069.1 - 0.14 11.3 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain eIF3_N PF09440.5 ESL12070.1 - 1.8e-22 79.9 0.4 4.9e-22 78.5 0.3 1.8 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 ESL12070.1 - 6.2e-09 36.1 0.0 2.1e-08 34.4 0.0 1.9 1 0 0 1 1 1 1 PCI domain TPR_12 PF13424.1 ESL12071.1 - 9.7e-06 25.4 4.4 0.32 10.9 0.0 4.0 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESL12071.1 - 6.9e-05 22.4 1.2 1.9 8.2 0.2 3.8 3 1 0 4 4 4 2 TPR repeat TPR_17 PF13431.1 ESL12071.1 - 0.046 13.9 0.4 9.6 6.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESL12071.1 - 0.077 12.8 1.4 2.8 7.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESL12071.1 - 2.1 8.4 5.6 31 4.8 0.5 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESL12073.1 - 4.2e-69 232.5 0.0 4.8e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL12073.1 - 3.1e-32 111.6 0.0 3.9e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESL12073.1 - 0.0001 21.3 0.0 0.00015 20.8 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.19 ESL12073.1 - 0.066 13.7 0.1 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain DUF4355 PF14265.1 ESL12074.1 - 1.1 9.2 5.0 3.2 7.7 3.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) PCRF PF03462.13 ESL12075.1 - 1.1e-11 44.4 0.3 3e-11 43.0 0.2 1.8 1 1 0 1 1 1 1 PCRF domain RF-1 PF00472.15 ESL12075.1 - 8.9e-10 38.3 0.0 4e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 RF-1 domain Toprim_Crpt PF13342.1 ESL12075.1 - 0.15 11.6 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase DHHA1 PF02272.14 ESL12075.1 - 0.26 11.0 3.1 0.29 10.8 0.3 2.4 3 0 0 3 3 3 0 DHHA1 domain Ank_2 PF12796.2 ESL12076.1 - 3.1e-10 40.2 0.0 5.9e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESL12076.1 - 9.3e-09 35.5 0.0 1.7e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESL12076.1 - 4.2e-08 32.6 0.0 1.7e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 ESL12076.1 - 1.7e-07 31.2 0.0 1.1e-05 25.5 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 ESL12076.1 - 2e-07 30.4 0.0 0.00016 21.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat TBP PF00352.16 ESL12077.1 - 5.6e-36 121.7 0.0 9e-17 60.2 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) TRM13 PF05206.9 ESL12079.1 - 6.1e-62 209.2 0.0 1e-59 201.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-U11-48K PF05253.7 ESL12079.1 - 4.5e-11 42.2 1.5 8.1e-11 41.4 1.1 1.5 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger zf-TRM13_CCCH PF11722.3 ESL12079.1 - 2.8e-09 36.1 3.1 2.8e-09 36.1 2.1 2.4 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein Ferric_reduct PF01794.14 ESL12080.1 - 3.2e-14 53.0 8.6 3.2e-14 53.0 5.9 3.9 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 ESL12080.1 - 7.9e-11 41.7 0.0 1.6e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 ESL12080.1 - 3.2e-10 40.1 0.0 3.5e-07 30.2 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 ESL12080.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESL12080.1 - 0.029 14.9 0.0 1.3 9.6 0.0 2.4 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain HSP70 PF00012.15 ESL12081.1 - 1.3e-64 218.2 3.8 1.5e-64 218.0 2.6 1.0 1 0 0 1 1 1 1 Hsp70 protein Pex19 PF04614.7 ESL12081.1 - 0.011 15.3 1.4 0.018 14.6 0.9 1.2 1 0 0 1 1 1 0 Pex19 protein family DUF4613 PF15390.1 ESL12081.1 - 0.22 9.6 1.9 0.29 9.2 1.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF2458 PF10454.4 ESL12081.1 - 0.36 10.7 5.1 0.72 9.7 3.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) Ribosomal_L16 PF00252.13 ESL12082.1 - 3.2e-21 75.4 0.0 4.3e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DnaJ PF00226.26 ESL12083.1 - 0.13 11.9 14.3 0.1 12.3 3.1 3.7 3 1 0 3 3 3 0 DnaJ domain DNA_mis_repair PF01119.14 ESL12084.1 - 5.4e-25 87.1 0.0 1e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 ESL12084.1 - 8.6e-11 41.6 0.0 1.8e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESL12084.1 - 6.4e-08 32.2 0.0 1.4e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IFT57 PF10498.4 ESL12084.1 - 0.12 11.1 2.7 0.18 10.5 1.8 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Kelch_3 PF13415.1 ESL12085.1 - 2.7e-25 87.8 0.1 7.9e-09 35.4 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESL12085.1 - 3.4e-21 74.7 0.1 3.1e-05 23.8 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESL12085.1 - 8.5e-19 66.8 0.2 0.0014 18.7 0.0 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESL12085.1 - 9.6e-18 63.4 0.0 0.0042 16.5 0.0 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 ESL12085.1 - 7.2e-17 60.8 3.4 0.00056 19.6 0.0 5.8 4 1 2 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESL12085.1 - 7.7e-11 41.3 6.2 0.15 11.9 0.0 7.1 8 0 0 8 8 8 3 Kelch motif DeoC PF01791.4 ESL12086.1 - 1.2e-42 145.7 7.3 1.5e-42 145.4 5.1 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase DUF2870 PF11069.3 ESL12089.1 - 2.8e-39 133.1 0.1 5.6e-39 132.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) Caps_synth_GfcC PF06251.6 ESL12089.1 - 0.021 14.0 0.1 0.17 11.0 0.0 2.0 2 0 0 2 2 2 0 Capsule biosynthesis GfcC C2 PF00168.25 ESL12091.1 - 1e-21 76.5 0.0 1.7e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.1 ESL12091.1 - 0.018 14.5 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain CHB_HEX_C PF03174.8 ESL12092.1 - 6.6e-13 48.3 0.4 2e-07 30.7 0.3 4.5 5 0 0 5 5 5 2 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C_1 PF13290.1 ESL12092.1 - 2.3e-10 40.1 2.9 1.3e-05 24.9 0.4 4.2 5 1 0 5 5 5 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 ESL12092.1 - 6.1e-10 39.0 0.5 3.9e-05 23.6 0.1 3.5 4 0 0 4 4 4 2 Fn3 associated Shisa PF13908.1 ESL12092.1 - 0.016 15.4 1.3 0.026 14.7 0.9 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SIT PF15330.1 ESL12092.1 - 0.027 14.6 0.1 0.051 13.7 0.1 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF3511 PF12023.3 ESL12092.1 - 0.12 11.7 0.2 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3511) Herpes_gE PF02480.11 ESL12092.1 - 0.38 8.9 2.2 0.7 8.0 1.5 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E UPF0560 PF10577.4 ESL12092.1 - 1.3 7.1 5.9 2 6.6 4.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Metallophos PF00149.23 ESL12093.1 - 1.4e-34 119.2 0.0 1.7e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 ESL12093.1 - 0.04 13.9 0.1 0.079 12.9 0.1 1.5 1 0 0 1 1 1 0 PPP5 TPR repeat region Strumpellin PF10266.4 ESL12094.1 - 0 1327.5 8.2 0 1327.3 5.7 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Dynactin PF12455.3 ESL12094.1 - 0.0037 16.2 4.8 0.042 12.7 0.2 2.7 3 0 0 3 3 3 2 Dynein associated protein DHC_N2 PF08393.8 ESL12095.1 - 1e-97 327.2 2.3 1e-97 327.2 1.6 1.8 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESL12095.1 - 2.9e-86 288.7 0.2 1.1e-84 283.5 0.0 2.4 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 ESL12095.1 - 8.8e-09 35.2 0.8 0.00022 20.9 0.0 4.3 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESL12095.1 - 1.6e-05 24.5 0.2 0.1 12.3 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA PF00004.24 ESL12095.1 - 6.4e-05 23.1 0.1 0.025 14.7 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESL12095.1 - 0.00064 20.5 1.2 0.14 12.9 0.0 4.2 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.17 ESL12095.1 - 0.00069 19.7 0.4 0.088 12.9 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA_22 PF13401.1 ESL12095.1 - 0.0018 18.4 0.2 0.43 10.7 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESL12095.1 - 0.0026 17.7 0.0 0.24 11.3 0.0 3.3 2 0 0 2 2 2 1 AAA ATPase domain DUF853 PF05872.7 ESL12095.1 - 0.005 15.2 0.6 0.71 8.1 0.1 2.5 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF853) AAA_18 PF13238.1 ESL12095.1 - 0.0065 16.7 0.1 0.31 11.3 0.0 3.1 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.7 ESL12095.1 - 0.007 15.4 1.3 5 6.1 0.0 3.5 3 0 0 3 3 3 1 Zeta toxin AAA_33 PF13671.1 ESL12095.1 - 0.038 13.8 1.5 10 5.9 0.1 3.2 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.17 ESL12095.1 - 0.039 13.3 1.3 4.5 6.6 0.2 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_14 PF13173.1 ESL12095.1 - 0.041 13.7 0.0 0.21 11.5 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESL12095.1 - 0.078 12.5 3.6 2.1 7.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain Hydrolase_3 PF08282.7 ESL12096.1 - 1.4e-39 136.2 0.0 3.3e-39 134.9 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 ESL12096.1 - 2.2e-11 43.5 0.1 2.8e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.2 ESL12096.1 - 0.00033 20.8 0.2 0.0036 17.4 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.11 ESL12096.1 - 0.0049 15.8 0.1 0.24 10.2 0.0 2.3 2 0 0 2 2 2 1 Trehalose-phosphatase Hydrolase PF00702.21 ESL12096.1 - 0.0078 16.6 0.7 1.7 8.9 0.0 2.4 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Peptidase_M16 PF00675.15 ESL12097.1 - 4.3e-37 127.1 0.0 8.2e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESL12097.1 - 8.1e-09 35.4 0.0 0.00064 19.4 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain EspA PF03433.8 ESL12097.1 - 0.31 10.4 0.0 0.55 9.6 0.0 1.3 1 0 0 1 1 1 0 EspA-like secreted protein IQ PF00612.22 ESL12098.1 - 0.0012 18.2 0.3 0.0051 16.3 0.2 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif Toxin_44 PF15523.1 ESL12098.1 - 0.73 9.7 3.5 11 5.9 0.6 2.7 2 0 0 2 2 2 0 Putative toxin 44 DUF2087 PF09860.4 ESL12098.1 - 0.73 9.6 8.1 4.9 6.9 0.2 3.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2087) GlutR_dimer PF00745.15 ESL12098.1 - 0.77 9.7 9.2 1.1 9.2 4.3 2.5 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain NAD_binding_1 PF00175.16 ESL12099.1 - 3e-20 72.8 0.0 5.4e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL12099.1 - 1.3e-11 44.4 0.0 2.3e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESL12099.1 - 0.00054 19.8 0.0 0.0046 16.8 0.0 2.0 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Herpes_US9 PF06072.6 ESL12101.1 - 0.15 11.9 1.5 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 DUF2361 PF10153.4 ESL12101.1 - 0.16 12.1 4.0 0.11 12.6 1.8 1.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2361) PTPlike_phytase PF14566.1 ESL12102.1 - 7.1e-25 87.7 0.1 2.6e-24 85.9 0.0 1.8 2 0 0 2 2 2 1 Inositol hexakisphosphate Abhydrolase_6 PF12697.2 ESL12103.1 - 5.8e-28 98.3 4.5 8.5e-28 97.7 3.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL12103.1 - 2.3e-12 46.9 0.0 3.2e-12 46.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL12103.1 - 3e-09 36.7 0.1 5.4e-09 35.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESL12103.1 - 0.00083 19.1 0.1 0.0022 17.7 0.1 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Esterase PF00756.15 ESL12103.1 - 0.0039 16.6 0.1 0.43 9.9 0.0 2.4 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.8 ESL12103.1 - 0.0092 15.5 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold PGAP1 PF07819.8 ESL12103.1 - 0.023 14.2 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2305 PF10230.4 ESL12103.1 - 0.091 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Thioesterase PF00975.15 ESL12103.1 - 0.11 12.7 1.7 0.76 9.9 1.2 2.2 1 1 0 1 1 1 0 Thioesterase domain Drc1-Sld2 PF11719.3 ESL12104.1 - 3.1e-05 23.2 0.2 0.039 13.0 0.1 2.3 2 0 0 2 2 2 2 DNA replication and checkpoint protein DUF3885 PF13021.1 ESL12104.1 - 0.01 15.4 0.3 0.024 14.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) DBR1 PF05011.8 ESL12105.1 - 3.2e-07 30.3 0.0 6.3e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 ESL12105.1 - 1.6e-06 27.6 0.3 0.0047 16.3 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESL12105.1 - 0.00046 20.0 0.0 0.001 18.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Y_phosphatase PF00102.22 ESL12107.1 - 4.2e-49 167.0 0.0 5.1e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 ESL12107.1 - 5.9e-06 25.9 0.0 1.1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESL12107.1 - 0.00031 20.7 0.0 0.00062 19.8 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 ESL12107.1 - 0.00034 20.8 0.0 0.00058 20.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PPR_3 PF13812.1 ESL12108.1 - 5.4e-12 44.9 0.2 1.8e-05 24.6 0.0 4.4 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.15 ESL12108.1 - 4.6e-11 41.9 0.1 0.0095 15.8 0.0 4.9 5 0 0 5 5 5 4 PPR repeat PPR_2 PF13041.1 ESL12108.1 - 7.6e-11 41.8 0.0 4.6e-05 23.3 0.0 3.8 2 1 2 4 4 4 3 PPR repeat family Pkinase PF00069.20 ESL12110.1 - 2.2e-34 118.8 0.0 2.6e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL12110.1 - 3.3e-15 55.8 0.0 3.8e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL12110.1 - 3.2e-06 27.0 0.1 0.00073 19.3 0.0 2.9 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.9 ESL12110.1 - 0.015 14.4 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL12110.1 - 0.041 12.8 0.0 0.2 10.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESL12110.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF2009 PF09418.5 ESL12111.1 - 1.5e-205 683.3 0.0 1.7e-205 683.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) RRM_1 PF00076.17 ESL12112.1 - 3.6e-12 45.7 0.1 7.3e-12 44.7 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL12112.1 - 7.3e-12 45.0 0.0 1.4e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL12112.1 - 2.7e-05 23.9 0.0 6.8e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.3 ESL12112.1 - 9.3e-05 22.3 1.8 0.00011 22.1 0.1 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G SET_assoc PF11767.3 ESL12112.1 - 0.033 13.5 0.2 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Rrp15p PF07890.7 ESL12112.1 - 0.036 14.1 2.6 0.73 9.8 0.2 2.5 1 1 1 2 2 2 0 Rrp15p Vps39_2 PF10367.4 ESL12114.1 - 1.1e-07 31.9 1.1 2.1e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-HC5HC2H_2 PF13832.1 ESL12114.1 - 0.015 15.3 3.1 0.015 15.3 2.2 1.7 1 1 1 2 2 2 0 PHD-zinc-finger like domain Prok-RING_1 PF14446.1 ESL12114.1 - 0.023 14.4 2.3 0.023 14.4 1.6 1.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.17 ESL12114.1 - 0.043 13.5 0.7 0.043 13.5 0.5 1.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.1 ESL12114.1 - 0.043 13.6 5.1 0.085 12.7 3.5 1.6 1 1 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.2 ESL12114.1 - 0.072 13.1 0.8 0.15 12.2 0.1 1.8 2 0 0 2 2 2 0 RING-H2 zinc finger zf-RING-like PF08746.6 ESL12114.1 - 0.077 13.0 2.1 0.19 11.7 1.5 1.7 1 0 0 1 1 1 0 RING-like domain zf-HC5HC2H PF13771.1 ESL12114.1 - 0.4 10.8 7.3 0.14 12.2 2.9 1.9 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING_5 PF14634.1 ESL12114.1 - 3 7.6 8.5 17 5.2 5.9 2.1 1 1 0 1 1 1 0 zinc-RING finger domain PHD PF00628.24 ESL12114.1 - 4 7.2 8.0 0.14 11.8 1.4 1.6 2 0 0 2 2 2 0 PHD-finger RRM_1 PF00076.17 ESL12115.1 - 3.2e-17 61.8 0.0 7.4e-17 60.7 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESL12115.1 - 1.4e-13 50.6 0.0 2.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESL12115.1 - 7.3e-06 25.7 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.27 ESL12116.1 - 5.9e-43 140.9 12.3 2e-10 39.2 0.7 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESL12116.1 - 2.5e-38 130.0 4.2 2.2e-21 75.7 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESL12116.1 - 2.2e-33 113.6 11.2 2.3e-16 59.1 0.5 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 ESL12116.1 - 2e-31 105.0 6.7 1.2e-09 37.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 ESL12116.1 - 2.9e-29 99.0 8.0 1.7e-07 30.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 ESL12116.1 - 8.6e-15 54.4 0.1 7.5e-08 32.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 ESL12116.1 - 1.1e-09 37.9 0.9 4.5e-05 23.1 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESL12116.1 - 3e-08 33.6 0.0 0.00049 20.0 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 ESL12116.1 - 1.9e-06 27.3 1.8 0.18 11.4 0.0 3.9 4 1 1 5 5 5 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 ESL12116.1 - 4.8e-06 26.4 1.2 5.9e-05 22.9 0.2 2.3 2 0 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.8 ESL12116.1 - 0.00022 20.9 0.3 0.082 12.6 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.8 ESL12116.1 - 0.00025 20.6 0.1 0.013 15.0 0.1 2.5 1 1 0 1 1 1 1 Caleosin related protein EF-hand_like PF09279.6 ESL12116.1 - 0.00033 20.6 1.2 0.0031 17.5 0.1 2.4 2 1 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like RNA_pol_Rpb4 PF03874.11 ESL12116.1 - 0.0038 17.2 0.5 1.7 8.6 0.1 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb4 DUF1103 PF06513.6 ESL12116.1 - 0.0051 16.2 1.1 0.0059 16.0 0.8 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) MotA_activ PF09114.5 ESL12116.1 - 0.021 14.5 0.1 4.2 7.1 0.0 2.3 2 0 0 2 2 2 0 Transcription factor MotA, activation domain Poly_export PF02563.11 ESL12116.1 - 0.042 13.6 0.2 11 5.8 0.0 3.1 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein LNS2 PF08235.8 ESL12116.1 - 0.045 13.3 0.1 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) Tenui_NCP PF04876.7 ESL12116.1 - 0.064 12.8 0.1 0.95 8.9 0.0 2.1 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein Toprim_2 PF13155.1 ESL12116.1 - 0.065 13.5 0.8 14 6.0 0.3 2.6 1 1 2 3 3 3 0 Toprim-like SpoVIF PF14069.1 ESL12116.1 - 0.077 12.7 0.8 1.6 8.5 0.1 2.6 3 0 0 3 3 3 0 Stage VI sporulation protein F DUF1880 PF08976.6 ESL12116.1 - 0.13 12.3 0.0 0.84 9.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1880) TPR_11 PF13414.1 ESL12117.1 - 2.9e-27 94.0 13.4 5.8e-12 45.0 0.4 5.1 3 1 2 5 5 5 4 TPR repeat TPR_1 PF00515.23 ESL12117.1 - 1.2e-22 78.4 18.7 1.2e-09 37.3 0.1 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESL12117.1 - 1.8e-18 64.8 18.3 1.9e-07 30.4 0.0 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESL12117.1 - 1.4e-16 60.6 3.1 8.5e-08 32.6 0.0 4.2 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESL12117.1 - 7.9e-16 56.5 13.3 4.5e-07 29.1 0.0 6.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL12117.1 - 9.5e-15 53.1 6.3 6.3e-07 28.7 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL12117.1 - 1.4e-13 50.5 8.2 3.9e-07 29.9 0.3 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESL12117.1 - 2.3e-13 49.1 11.9 3.8e-05 23.5 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL12117.1 - 2e-12 46.5 1.5 5.3e-05 23.4 0.0 4.7 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESL12117.1 - 2.9e-12 46.7 7.2 8.5e-07 29.2 0.5 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESL12117.1 - 6.4e-11 41.9 5.2 7.8e-05 22.8 0.0 6.0 7 0 0 7 7 6 2 Tetratricopeptide repeat Apc3 PF12895.2 ESL12117.1 - 3.2e-07 30.4 8.5 8.3e-06 25.8 1.0 4.0 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESL12117.1 - 7.6e-06 25.6 4.8 0.00082 19.1 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESL12117.1 - 0.00098 18.9 8.9 0.1 12.5 0.0 4.3 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESL12117.1 - 0.0063 16.6 0.1 5.5 7.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.9 ESL12117.1 - 0.061 13.7 0.1 11 6.7 0.1 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat AIG1 PF04548.11 ESL12117.1 - 1 8.4 5.7 2.9 6.9 0.2 2.2 2 0 0 2 2 2 0 AIG1 family MIT PF04212.13 ESL12117.1 - 4.5 7.2 12.7 5.6 6.9 0.7 4.2 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain MMR_HSR1 PF01926.18 ESL12118.1 - 2.4e-12 46.8 0.0 3.9e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESL12118.1 - 2.7e-06 27.3 0.1 0.0001 22.1 0.1 2.3 1 1 1 2 2 2 1 Dynamin family DUF258 PF03193.11 ESL12118.1 - 0.0001 21.5 0.0 0.00025 20.2 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESL12118.1 - 0.0014 18.1 0.0 4.6 6.6 0.0 3.1 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ESL12118.1 - 0.0022 17.4 0.0 0.0047 16.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MobB PF03205.9 ESL12118.1 - 0.017 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.13 ESL12118.1 - 0.019 14.2 0.1 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.22 ESL12118.1 - 0.081 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.7 ESL12118.1 - 0.088 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Miro PF08477.8 ESL12118.1 - 0.14 12.6 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein Lipase_3 PF01764.20 ESL12119.1 - 2.9e-39 133.8 0.0 4e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESL12119.1 - 0.00011 21.7 0.0 0.0019 17.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.2 ESL12119.1 - 0.0037 17.1 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESL12119.1 - 0.032 14.0 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2048 PF09752.4 ESL12119.1 - 0.033 13.0 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) PDEase_I PF00233.14 ESL12121.1 - 1.7e-61 208.0 0.7 3.1e-61 207.1 0.1 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.21 ESL12121.1 - 9.8e-44 149.1 0.1 2.9e-21 76.1 0.0 2.8 3 0 0 3 3 3 2 GAF domain GAF_2 PF13185.1 ESL12121.1 - 5.4e-17 62.6 0.3 5.6e-08 33.4 0.1 2.6 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.1 ESL12121.1 - 5.3e-16 58.9 0.1 2.6e-09 37.2 0.0 2.4 2 0 0 2 2 2 2 GAF domain zf-B_box PF00643.19 ESL12122.1 - 6.7e-06 25.9 2.0 1.5e-05 24.7 1.4 1.5 1 0 0 1 1 1 1 B-box zinc finger Exonuc_VII_L PF02601.10 ESL12122.1 - 0.012 14.8 0.9 0.02 14.1 0.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mnd1 PF03962.10 ESL12122.1 - 0.031 13.9 2.3 0.44 10.1 1.8 2.3 2 0 0 2 2 2 0 Mnd1 family AAA_13 PF13166.1 ESL12122.1 - 0.079 11.4 0.7 0.11 10.9 0.5 1.1 1 0 0 1 1 1 0 AAA domain DUF2421 PF10334.4 ESL12122.1 - 0.13 11.8 0.2 0.44 10.1 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2421) PilJ PF13675.1 ESL12122.1 - 0.15 12.3 1.0 0.32 11.3 0.2 2.0 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2317 PF10079.4 ESL12122.1 - 0.16 10.5 2.7 0.22 10.0 1.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) GST_C_2 PF13410.1 ESL12122.1 - 0.22 11.4 0.9 9.3 6.2 0.4 3.0 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Lectin_N PF03954.9 ESL12122.1 - 0.26 10.6 1.4 0.94 8.8 0.2 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF2205 PF10224.4 ESL12122.1 - 0.56 9.8 3.2 0.95 9.0 1.2 2.0 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) HEAT_2 PF13646.1 ESL12124.1 - 1.9e-07 31.2 11.5 0.00057 20.1 0.5 5.0 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.17 ESL12124.1 - 1.9 8.7 10.0 2.1 8.6 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat Evr1_Alr PF04777.8 ESL12125.1 - 1e-14 54.1 0.0 2.2e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Erv1 / Alr family DUF2296 PF10058.4 ESL12125.1 - 0.081 12.6 0.0 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Abhydrolase_6 PF12697.2 ESL12126.1 - 6.2e-27 94.9 0.5 9.9e-27 94.2 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESL12126.1 - 7.1e-19 68.2 0.1 8.2e-18 64.7 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESL12126.1 - 2.2e-15 56.6 0.0 4e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 ESL12126.1 - 0.0019 18.0 0.0 0.0079 16.0 0.0 1.9 2 0 0 2 2 2 1 TAP-like protein Ndr PF03096.9 ESL12126.1 - 0.011 14.2 0.0 0.017 13.6 0.0 1.2 1 0 0 1 1 1 0 Ndr family Esterase PF00756.15 ESL12126.1 - 0.017 14.5 0.0 0.04 13.3 0.0 1.6 2 0 0 2 2 2 0 Putative esterase Thioesterase PF00975.15 ESL12126.1 - 0.041 14.1 0.1 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 ESL12126.1 - 0.073 12.6 0.1 0.6 9.6 0.1 2.4 2 1 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESL12126.1 - 0.075 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase FAM177 PF14774.1 ESL12126.1 - 0.096 12.6 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 FAM177 family Patatin PF01734.17 ESL12126.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Patatin-like phospholipase Abhydrolase_2 PF02230.11 ESL12126.1 - 0.12 11.8 0.1 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 ESL12126.1 - 0.17 11.0 0.0 6 6.0 0.0 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family FAM183 PF14886.1 ESL12127.1 - 1.3e-05 25.7 0.2 3.6e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 FAM183A and FAM183B related LLC1 PF14945.1 ESL12127.1 - 1.8 8.9 5.5 14 6.0 3.1 2.3 1 1 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Amidinotransf PF02274.12 ESL12130.1 - 0.0038 16.3 0.3 0.021 13.9 0.0 2.2 2 0 0 2 2 2 1 Amidinotransferase DER1 PF04511.10 ESL12132.1 - 4.1e-28 98.2 2.7 4.9e-28 97.9 1.9 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 ESL12132.1 - 4 7.4 13.7 8.6 6.3 0.1 2.6 1 1 0 2 2 2 0 Rhomboid family Kua-UEV1_localn PF10520.4 ESL12133.1 - 5.7e-68 228.0 5.4 8.5e-68 227.5 3.8 1.2 1 0 0 1 1 1 1 Kua-ubiquitin conjugating enzyme hybrid localisation domain Antimicrobial10 PF08105.6 ESL12134.1 - 0.043 13.4 0.1 0.17 11.5 0.1 2.0 1 0 0 1 1 1 0 Metchnikowin family Med13_C PF06333.7 ESL12134.1 - 0.13 10.7 0.7 0.19 10.2 0.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal PPR PF01535.15 ESL12135.1 - 0.13 12.2 0.6 0.66 10.0 0.1 2.3 2 0 0 2 2 2 0 PPR repeat Dynamin_N PF00350.18 ESL12137.1 - 2.1e-18 66.7 0.0 5.2e-17 62.1 0.0 2.4 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESL12137.1 - 1.3e-08 34.7 0.0 3.4e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase MRP PF09387.5 ESL12138.1 - 1.7e-67 226.9 0.4 2e-67 226.6 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP LRR_4 PF12799.2 ESL12139.1 - 4.1e-06 26.2 0.0 0.04 13.5 0.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESL12139.1 - 0.00024 20.8 0.0 0.15 11.8 0.0 3.5 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESL12139.1 - 0.0081 16.0 0.4 1.8 8.9 0.2 3.1 2 0 0 2 2 2 1 Leucine Rich Repeat LRR_7 PF13504.1 ESL12139.1 - 0.23 11.7 1.1 13 6.5 0.3 3.6 3 0 0 3 3 3 0 Leucine rich repeat DUF21 PF01595.15 ESL12140.1 - 1.2e-33 115.9 0.3 2.4e-33 114.9 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESL12140.1 - 1.5e-07 31.0 0.3 0.001 18.8 0.1 2.5 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.24 ESL12140.1 - 0.005 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain UBACT PF02134.16 ESL12141.1 - 8.3e-25 86.1 0.4 1.4e-24 85.4 0.3 1.4 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein Aminotran_1_2 PF00155.16 ESL12142.1 - 5.6e-17 61.7 0.0 8.1e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Metal_resist PF13801.1 ESL12143.1 - 0.027 14.4 3.8 0.027 14.4 2.6 3.1 3 0 0 3 3 3 0 Heavy-metal resistance DUF3138 PF11336.3 ESL12143.1 - 0.6 8.2 3.7 0.76 7.8 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) GBA2_N PF12215.3 ESL12143.1 - 1.1 8.3 3.9 1.6 7.7 2.6 1.6 1 1 0 1 1 1 0 beta-Glucocerebrosidase 2 N terminal GP41 PF00517.12 ESL12143.1 - 2.9 7.3 9.0 2 7.9 3.8 2.2 2 0 0 2 2 2 0 Retroviral envelope protein Exonuc_VII_L PF02601.10 ESL12143.1 - 9.7 5.2 18.9 14 4.7 13.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit OGG_N PF07934.7 ESL12144.1 - 3.4e-24 85.0 0.0 5.8e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 ESL12144.1 - 1.6e-11 44.4 0.0 4.8e-11 42.8 0.0 1.8 2 1 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 ESL12144.1 - 2.3e-05 23.8 0.1 8.4e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif MRP-L46 PF11788.3 ESL12145.1 - 7e-11 42.7 0.1 2.2e-10 41.1 0.1 1.9 1 1 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NAD_binding_1 PF00175.16 ESL12146.1 - 4e-17 62.7 0.0 6.1e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESL12146.1 - 2.6e-09 37.0 0.0 4.4e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESL12146.1 - 5.1e-06 26.4 0.1 0.0017 18.2 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_2 PF00890.19 ESL12146.1 - 9.5e-06 24.7 0.5 1.3e-05 24.2 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain P34-Arc PF04045.9 ESL12147.1 - 7.8e-27 94.1 0.0 1.1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc MMR_HSR1 PF01926.18 ESL12151.1 - 1.7e-20 73.0 0.1 1.1e-14 54.3 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESL12151.1 - 2.2e-12 46.5 0.5 1.6e-08 34.0 0.3 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.18 ESL12151.1 - 1.3e-05 25.0 1.4 0.0067 16.2 0.3 3.0 2 1 1 3 3 3 1 Dynamin family GTP_EFTU PF00009.22 ESL12151.1 - 6.5e-05 22.4 0.2 0.013 14.9 0.0 3.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.16 ESL12151.1 - 0.00017 20.8 0.2 0.33 10.1 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family AIG1 PF04548.11 ESL12151.1 - 0.00042 19.4 0.3 0.15 11.1 0.1 2.3 2 0 0 2 2 2 2 AIG1 family DUF258 PF03193.11 ESL12151.1 - 0.00086 18.5 0.0 0.0017 17.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 ESL12151.1 - 0.0027 18.1 0.2 0.58 10.6 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein ArgK PF03308.11 ESL12151.1 - 0.037 12.8 0.0 0.065 11.9 0.0 1.4 1 0 0 1 1 1 0 ArgK protein AAA_17 PF13207.1 ESL12151.1 - 0.084 13.6 0.3 0.34 11.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain Taeniidae_ag PF05596.6 ESL12151.1 - 0.15 11.9 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Taeniidae antigen Dymeclin PF09742.4 ESL12152.1 - 1.4e-117 393.5 0.1 1.7e-117 393.3 0.1 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein CAAP1 PF15335.1 ESL12152.1 - 0.16 12.2 0.5 0.38 10.9 0.3 1.6 1 0 0 1 1 1 0 Caspase activity and apoptosis inhibitor 1 Hid1 PF12722.2 ESL12152.1 - 0.26 8.9 3.3 3.6 5.1 0.2 2.4 2 1 0 2 2 2 0 High-temperature-induced dauer-formation protein LysM PF01476.15 ESL12153.1 - 0.00059 19.6 0.0 0.26 11.2 0.0 2.4 2 0 0 2 2 2 2 LysM domain GlcNAc PF11397.3 ESL12154.1 - 1.2e-108 363.3 0.0 1.7e-108 362.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) FAD_binding_4 PF01565.18 ESL12155.1 - 0.0076 15.7 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain MBOAT_2 PF13813.1 ESL12155.1 - 0.045 13.8 0.2 0.091 12.8 0.1 1.5 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family SET PF00856.23 ESL12156.1 - 2e-07 31.4 0.3 3e-06 27.6 0.2 2.3 1 1 0 1 1 1 1 SET domain PBP1_TM PF14812.1 ESL12156.1 - 0.23 11.7 2.9 0.48 10.7 2.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NAD_binding_1 PF00175.16 ESL12157.1 - 3.2e-13 50.1 0.0 4.8e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESL12157.1 - 0.00013 21.9 0.0 0.0073 16.2 0.0 2.2 1 1 0 2 2 2 2 Ferric reductase NAD binding domain Skp1_POZ PF03931.10 ESL12158.1 - 0.003 17.6 0.0 0.037 14.1 0.0 2.1 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain Carn_acyltransf PF00755.15 ESL12159.1 - 4e-63 213.4 0.0 7.2e-63 212.6 0.0 1.3 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Glyco_hydro_65m PF03632.10 ESL12160.1 - 2e-67 227.4 0.0 3.6e-67 226.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 ESL12160.1 - 3.2e-28 98.7 0.2 1.3e-26 93.5 0.0 2.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain HAD_2 PF13419.1 ESL12160.1 - 2e-06 28.1 0.0 5.5e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Glyco_hydro_65C PF03633.10 ESL12160.1 - 1.9e-05 24.6 0.0 5.3e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain DUF524 PF04411.7 ESL12160.1 - 0.16 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF524) DUF3619 PF12279.3 ESL12161.1 - 0.098 12.7 0.8 0.18 11.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Arm PF00514.18 ESL12162.1 - 9.9e-41 136.2 11.9 1.4e-07 31.0 0.0 7.2 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat HEAT PF02985.17 ESL12162.1 - 1.6e-24 83.6 6.4 8.7e-06 25.3 0.0 7.5 7 1 0 7 7 7 6 HEAT repeat HEAT_2 PF13646.1 ESL12162.1 - 3.3e-24 84.9 11.0 6.2e-08 32.8 0.0 4.9 1 1 3 5 5 5 5 HEAT repeats HEAT_EZ PF13513.1 ESL12162.1 - 1.5e-19 69.8 19.0 0.00016 22.0 0.1 6.2 3 1 4 7 7 7 7 HEAT-like repeat Adaptin_N PF01602.15 ESL12162.1 - 2.8e-12 45.7 0.9 7.7e-06 24.4 0.1 3.4 2 1 2 4 4 4 2 Adaptin N terminal region Proteasom_PSMB PF10508.4 ESL12162.1 - 5.9e-10 38.0 0.1 3.7e-07 28.7 0.0 2.9 1 1 2 3 3 3 1 Proteasome non-ATPase 26S subunit DNA_alkylation PF08713.6 ESL12162.1 - 5.7e-08 32.5 0.0 0.019 14.4 0.0 4.0 2 1 1 4 4 4 2 DNA alkylation repair enzyme Cnd1 PF12717.2 ESL12162.1 - 6.1e-08 32.7 0.2 3e-05 23.9 0.1 3.6 1 1 3 4 4 4 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 ESL12162.1 - 0.0001 21.7 0.3 0.034 13.5 0.1 2.8 1 1 1 2 2 2 1 CLASP N terminal Vac14_Fab1_bd PF12755.2 ESL12162.1 - 0.00044 20.5 0.1 0.018 15.4 0.0 2.9 1 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region V-ATPase_H_C PF11698.3 ESL12162.1 - 0.0017 18.2 0.3 0.031 14.1 0.1 2.7 3 0 0 3 3 3 1 V-ATPase subunit H DUF3731 PF12531.3 ESL12162.1 - 0.025 14.0 3.0 2.5 7.5 0.1 3.4 2 1 1 4 4 4 0 DNA-K related protein DUF3730 PF12530.3 ESL12162.1 - 0.026 14.4 6.5 0.066 13.1 1.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3730) Nipped-B_C PF12830.2 ESL12162.1 - 0.027 14.1 0.5 0.3 10.7 0.1 2.6 2 1 1 3 3 3 0 Sister chromatid cohesion C-terminus HEAT_PBS PF03130.11 ESL12162.1 - 0.028 14.8 14.8 3.4 8.4 0.1 6.2 8 0 0 8 8 5 0 PBS lyase HEAT-like repeat OHCU_decarbox PF09349.5 ESL12162.1 - 0.034 14.4 1.4 2.2 8.5 0.0 3.3 2 1 1 3 3 3 0 OHCU decarboxylase Xpo1 PF08389.7 ESL12162.1 - 0.034 14.0 0.1 0.094 12.6 0.1 1.8 1 0 0 1 1 1 0 Exportin 1-like protein Mo25 PF08569.6 ESL12162.1 - 0.058 12.4 0.0 0.35 9.8 0.0 2.0 2 0 0 2 2 2 0 Mo25-like Chitin_synth_1 PF01644.12 ESL12162.1 - 0.095 12.4 0.0 2.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Chitin synthase EMP70 PF02990.11 ESL12163.1 - 1.6e-10 40.1 6.3 1.6e-10 40.1 4.4 1.4 1 1 0 1 1 1 1 Endomembrane protein 70 PsbM PF05151.7 ESL12163.1 - 0.025 14.1 0.3 0.063 12.8 0.2 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre M protein (PsbM) Pam17 PF08566.5 ESL12163.1 - 0.26 10.9 1.4 0.28 10.8 0.9 1.0 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 DUF4013 PF13197.1 ESL12163.1 - 1.3 8.3 10.2 2.2 7.6 7.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4013) MORN PF02493.15 ESL12165.1 - 3.1e-07 29.7 18.4 0.022 14.4 1.8 5.7 6 0 0 6 6 6 3 MORN repeat zf-RanBP PF00641.13 ESL12166.1 - 2e-25 87.5 52.1 3.9e-06 25.8 1.3 6.4 6 0 0 6 6 6 6 Zn-finger in Ran binding protein and others DZR PF12773.2 ESL12166.1 - 2.4e-05 24.0 43.3 0.14 11.9 7.1 4.8 1 1 3 4 4 4 4 Double zinc ribbon Rubredoxin PF00301.15 ESL12166.1 - 0.023 14.5 0.3 0.023 14.5 0.2 7.1 6 4 0 6 6 6 0 Rubredoxin DUF35_N PF12172.3 ESL12166.1 - 0.055 13.3 2.0 0.055 13.3 1.4 5.9 6 0 0 6 6 6 0 Rubredoxin-like zinc ribbon domain (DUF35_N) FA_desaturase PF00487.19 ESL12167.1 - 6.2e-14 52.0 21.9 7.8e-14 51.7 15.2 1.1 1 0 0 1 1 1 1 Fatty acid desaturase zf-HC5HC2H PF13771.1 ESL12168.1 - 1.1e-16 60.7 9.8 2.5e-15 56.3 4.4 2.5 2 0 0 2 2 2 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESL12168.1 - 9.7e-12 44.8 13.8 1.8e-11 44.0 9.6 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-Apc11 PF12861.2 ESL12168.1 - 1.2 8.9 10.3 0.056 13.2 2.5 2.1 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RabGAP-TBC PF00566.13 ESL12169.1 - 2.7e-08 33.5 0.0 4.1e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.15 ESL12169.1 - 0.1 12.9 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Rhodanese-like domain MMR_HSR1 PF01926.18 ESL12170.1 - 5e-12 45.7 0.0 8.8e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESL12170.1 - 3.3e-05 23.1 0.0 6.1e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESL12170.1 - 0.00035 20.0 0.0 0.032 13.6 0.0 2.5 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESL12170.1 - 0.081 12.1 0.0 0.3 10.3 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B PseudoU_synth_1 PF01416.15 ESL12171.1 - 8.5e-16 58.2 0.0 1.9e-07 31.4 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase AF1Q PF15017.1 ESL12171.1 - 0.79 9.6 4.5 0.71 9.8 2.2 1.6 1 1 0 1 1 1 0 Drug resistance and apoptosis regulator Glyco_transf_22 PF03901.12 ESL12172.1 - 5.4e-101 338.6 28.3 6.6e-101 338.3 19.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DPM3 PF08285.6 ESL12172.1 - 0.42 10.5 11.3 0.18 11.6 1.9 3.4 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Piwi PF02171.12 ESL12173.1 - 6.8e-12 44.9 0.0 1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Piwi domain Mito_fiss_reg PF05308.6 ESL12173.1 - 0.52 9.6 11.7 0.035 13.4 2.0 2.7 3 0 0 3 3 3 0 Mitochondrial fission regulator PP2C PF00481.16 ESL12174.1 - 7.3e-57 192.6 0.0 9.7e-57 192.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESL12174.1 - 0.00066 19.1 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C BK_channel_a PF03493.13 ESL12175.1 - 2.9e-15 56.0 0.0 8.9e-15 54.4 0.0 1.9 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.11 ESL12175.1 - 5.5e-09 35.6 8.9 5.5e-09 35.6 6.2 2.7 2 0 0 2 2 2 1 Ion channel HTH_31 PF13560.1 ESL12175.1 - 0.35 11.1 3.0 1.6 8.9 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain TM231 PF10149.4 ESL12176.1 - 9.7e-11 41.2 0.3 0.00019 20.5 0.0 2.2 2 0 0 2 2 2 2 Transmembrane protein 231 DDRGK PF09756.4 ESL12178.1 - 3.6e-23 81.9 47.3 3.3e-19 69.0 3.3 3.2 2 1 1 3 3 3 2 DDRGK domain DHHW PF14286.1 ESL12178.1 - 2.6 7.2 4.9 0.81 8.9 1.4 1.5 2 0 0 2 2 2 0 DHHW protein Ycf1 PF05758.7 ESL12178.1 - 3.1 5.3 11.5 4 5.0 8.0 1.1 1 0 0 1 1 1 0 Ycf1 Apis_Csd PF11671.3 ESL12178.1 - 6 6.6 11.8 11 5.7 8.2 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein ubiquitin PF00240.18 ESL12180.1 - 0.0045 16.3 0.0 0.0076 15.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family HemS PF05171.7 ESL12181.1 - 0.049 13.4 0.4 0.18 11.6 0.2 1.9 2 0 0 2 2 2 0 Haemin-degrading HemS.ChuX domain DUF1444 PF07285.6 ESL12181.1 - 0.062 12.6 2.7 0.093 12.0 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1444) Spc7 PF08317.6 ESL12181.1 - 0.11 11.1 6.5 0.15 10.6 4.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.7 ESL12181.1 - 0.27 10.2 7.7 0.38 9.7 5.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 LMBR1 PF04791.11 ESL12182.1 - 2.3e-27 95.7 30.8 6.6e-27 94.2 21.2 1.9 1 1 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_S18 PF01084.15 ESL12183.1 - 0.0012 18.6 0.1 0.0037 17.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 HTH_OrfB_IS605 PF12323.3 ESL12183.1 - 0.075 12.3 1.1 4.5 6.6 0.2 3.0 2 0 0 2 2 2 0 Helix-turn-helix domain zf-rbx1 PF12678.2 ESL12184.1 - 1.9e-05 24.6 6.2 5.6e-05 23.1 4.3 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESL12184.1 - 3e-05 23.7 3.5 3e-05 23.7 2.5 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESL12184.1 - 0.0097 15.9 2.8 0.0097 15.9 1.9 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESL12184.1 - 0.86 9.4 10.5 0.26 11.1 4.4 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pentapeptide PF00805.17 ESL12185.1 - 4.8e-08 32.0 5.0 0.037 13.2 0.5 4.1 1 1 3 4 4 4 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.1 ESL12185.1 - 8.4e-08 31.9 6.3 1.8e-06 27.6 4.4 2.2 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 ESL12185.1 - 7.4e-07 28.9 11.8 0.0023 17.7 4.7 2.5 2 0 0 2 2 2 2 Pentapeptide repeats (9 copies) MIP-T3 PF10243.4 ESL12186.1 - 1.1e-15 57.1 1.1 2.2e-14 52.8 0.2 2.1 2 0 0 2 2 2 2 Microtubule-binding protein MIP-T3 SusE PF14292.1 ESL12187.1 - 0.12 12.1 1.0 0.18 11.6 0.7 1.2 1 0 0 1 1 1 0 SusE outer membrane protein ThiF PF00899.16 ESL12188.1 - 6.1e-28 97.3 0.0 9.8e-28 96.6 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 ESL12188.1 - 2.3e-05 24.5 0.0 0.0023 18.0 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 ESL12188.1 - 0.0044 15.9 0.0 0.0065 15.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.14 ESL12188.1 - 0.15 11.1 0.0 5.9 6.0 0.0 2.4 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SNARE_assoc PF09335.6 ESL12189.1 - 5.3e-11 42.7 0.9 5.3e-11 42.7 0.6 3.2 2 1 0 2 2 2 1 SNARE associated Golgi protein EF-hand_5 PF13202.1 ESL12189.1 - 0.00097 18.3 0.2 0.0029 16.8 0.0 1.8 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.27 ESL12189.1 - 0.0061 15.7 0.1 0.023 13.9 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 ESL12189.1 - 0.014 15.5 0.0 0.067 13.3 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 ESL12189.1 - 0.033 14.0 0.1 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain TPR_11 PF13414.1 ESL12191.1 - 7.6e-23 79.9 1.9 1.1e-15 57.0 0.1 2.5 1 1 1 2 2 2 2 TPR repeat RPAP3_C PF13877.1 ESL12191.1 - 6.9e-18 64.4 0.0 1.3e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_2 PF07719.12 ESL12191.1 - 2.7e-17 61.2 0.6 0.00013 21.6 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESL12191.1 - 2.8e-17 61.5 0.2 0.00014 21.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESL12191.1 - 1.8e-10 40.5 2.4 1.6e-08 34.2 0.9 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESL12191.1 - 6.1e-08 32.6 0.2 0.018 15.6 0.1 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESL12191.1 - 6.4e-08 33.0 0.2 0.00068 20.2 0.5 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESL12191.1 - 4.6e-07 29.1 0.1 0.51 10.2 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESL12191.1 - 6e-06 26.1 0.1 0.0025 17.7 0.5 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESL12191.1 - 8.7e-05 22.4 0.5 2.3 8.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESL12191.1 - 0.00015 21.2 0.2 0.07 12.9 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESL12191.1 - 0.0002 21.3 0.0 0.00057 19.9 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESL12191.1 - 0.0016 18.7 0.0 0.055 13.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESL12191.1 - 0.0031 17.8 0.1 0.52 10.8 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat CDC45 PF02724.9 ESL12191.1 - 0.16 9.9 12.9 0.26 9.2 9.0 1.4 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_viral_N PF00242.12 ESL12191.1 - 1.7 7.5 12.5 2.6 6.9 8.7 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Spt5_N PF11942.3 ESL12191.1 - 3.8 8.1 22.0 0.22 12.1 10.9 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Ribosomal_L10 PF00466.15 ESL12192.1 - 2.7e-17 62.5 0.0 3.7e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 CS PF04969.11 ESL12194.1 - 2.5e-13 50.3 0.0 3.6e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 CS domain Motile_Sperm PF00635.21 ESL12195.1 - 1.2e-09 37.8 0.0 0.004 16.7 0.0 6.3 7 0 0 7 7 7 2 MSP (Major sperm protein) domain MYCBPAP PF14646.1 ESL12195.1 - 0.00045 19.0 0.0 8.8 4.9 0.0 3.9 4 0 0 4 4 4 3 MYCBP-associated protein family Proteasome PF00227.21 ESL12197.1 - 6.1e-24 84.3 0.7 2.2e-23 82.5 0.5 1.7 1 1 0 1 1 1 1 Proteasome subunit PAT1 PF09770.4 ESL12198.1 - 1.5 6.9 10.4 1.8 6.7 7.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PGK PF00162.14 ESL12199.1 - 1.2e-104 349.9 0.0 1.7e-104 349.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoglycerate kinase cNMP_binding PF00027.24 ESL12199.1 - 0.00023 20.9 0.0 0.00046 19.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Zein PF01559.11 ESL12199.1 - 0.027 13.7 0.5 0.045 12.9 0.3 1.3 1 0 0 1 1 1 0 Zein seed storage protein Actin PF00022.14 ESL12200.1 - 8.3e-148 492.0 0.0 9.7e-148 491.7 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ESL12200.1 - 0.012 16.0 0.1 0.13 12.6 0.0 2.2 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) SCO1-SenC PF02630.9 ESL12204.1 - 1.3e-41 142.0 0.0 1.8e-41 141.6 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 ESL12204.1 - 0.0099 15.5 0.0 0.026 14.1 0.0 1.8 1 1 0 1 1 1 1 AhpC/TSA family Cnd2 PF05786.9 ESL12206.1 - 3.3e-23 82.1 1.9 2.6e-10 39.5 1.1 3.1 3 1 0 3 3 3 2 Condensin complex subunit 2 DUF3342 PF11822.3 ESL12207.1 - 2.4e-122 408.0 1.1 3.2e-122 407.6 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) DUF4313 PF14190.1 ESL12207.1 - 0.13 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4313) HTH_Tnp_Tc5 PF03221.11 ESL12208.1 - 0.11 12.3 2.0 1.8 8.4 0.1 2.6 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF342 PF03961.8 ESL12208.1 - 6.3 5.0 16.9 0.92 7.8 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) RNA_binding PF01877.12 ESL12208.1 - 9.4 6.2 11.6 0.1 12.6 1.1 2.9 3 2 1 4 4 4 0 RNA binding DUF2379 PF09543.5 ESL12209.1 - 0.027 14.4 0.7 0.044 13.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) Closter_coat PF01785.12 ESL12209.1 - 0.035 13.1 0.0 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 Closterovirus coat protein AAA PF00004.24 ESL12210.1 - 6e-15 55.6 0.0 1.2e-07 31.9 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESL12210.1 - 0.00016 21.6 0.2 0.00085 19.3 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESL12210.1 - 0.00037 20.6 0.0 0.00092 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESL12210.1 - 0.00061 19.5 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) PKD_channel PF08016.7 ESL12210.1 - 0.00067 18.1 1.0 0.00097 17.6 0.7 1.1 1 0 0 1 1 1 1 Polycystin cation channel AAA_17 PF13207.1 ESL12210.1 - 0.00099 19.9 0.2 0.0075 17.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 ESL12210.1 - 0.0039 17.1 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 ESL12210.1 - 0.0067 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESL12210.1 - 0.01 15.5 0.1 0.12 12.1 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain DUF815 PF05673.8 ESL12210.1 - 0.017 14.0 0.0 0.037 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 ESL12210.1 - 0.02 14.2 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.1 ESL12210.1 - 0.037 13.5 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.17 ESL12210.1 - 0.044 13.9 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.1 ESL12210.1 - 0.049 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESL12210.1 - 0.076 12.8 0.1 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 ESL12210.1 - 0.099 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_23 PF13476.1 ESL12210.1 - 0.13 12.5 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain PPV_E1_C PF00519.12 ESL12210.1 - 0.14 10.7 0.0 0.21 10.1 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase Pkinase PF00069.20 ESL12211.1 - 4.7e-53 179.9 0.0 6.5e-53 179.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESL12211.1 - 3.2e-40 137.8 0.0 7.9e-40 136.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESL12211.1 - 0.013 15.1 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESL12211.1 - 0.019 14.0 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESL12211.1 - 0.16 10.9 0.0 3.7 6.4 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Proteasome PF00227.21 ESL12212.1 - 5e-36 123.7 0.0 5.6e-36 123.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DNA_pol_B_exo1 PF03104.14 ESL12213.1 - 2.1e-49 168.1 0.1 3.3e-49 167.5 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.7 ESL12213.1 - 1.1e-43 149.3 0.8 2.7e-42 144.7 0.0 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.16 ESL12213.1 - 2.1e-18 66.3 0.0 3.2e-16 59.1 0.0 3.0 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 ESL12213.1 - 1.8e-09 37.4 1.2 7.5e-07 28.8 0.0 3.2 3 0 0 3 3 3 2 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 ESL12213.1 - 1.1e-07 31.8 0.2 5.1e-07 29.6 0.1 2.2 2 1 0 2 2 2 1 RNase_H superfamily eIF-4B PF06273.6 ESL12213.1 - 0.024 13.3 1.8 0.04 12.6 1.2 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B FHA PF00498.21 ESL12215.1 - 6.5e-05 22.9 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain SNF2_N PF00176.18 ESL12216.1 - 1.1e-43 149.1 0.0 1.5e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESL12216.1 - 7.3e-13 48.1 0.0 1.7e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.24 ESL12216.1 - 1.8e-07 30.7 11.6 2.7e-05 23.7 0.7 3.0 3 0 0 3 3 3 2 PHD-finger C1_1 PF00130.17 ESL12216.1 - 0.00068 19.3 0.5 0.00068 19.3 0.4 3.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF282 PF03380.9 ESL12216.1 - 0.0061 16.2 0.3 0.017 14.8 0.2 1.8 1 0 0 1 1 1 1 Caenorhabditis protein of unknown function, DUF282 C1_2 PF03107.11 ESL12216.1 - 0.021 14.9 1.6 0.021 14.9 1.1 2.9 3 0 0 3 3 3 0 C1 domain ResIII PF04851.10 ESL12216.1 - 0.039 13.7 0.0 0.59 9.9 0.0 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit zf-PHD-like PF15446.1 ESL12216.1 - 0.78 9.0 7.0 2.3 7.4 0.3 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain IBR PF01485.16 ESL12216.1 - 7.9 6.4 17.0 1.6e+02 2.2 11.8 2.8 1 1 0 1 1 1 0 IBR domain CAS_CSE1 PF03378.10 ESL12217.1 - 5.4e-88 295.1 0.0 3.1e-87 292.6 0.0 2.1 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus Cse1 PF08506.5 ESL12217.1 - 4.1e-64 216.4 0.0 5.7e-64 216.0 0.0 1.2 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.14 ESL12217.1 - 5e-05 23.1 0.0 0.00028 20.7 0.0 2.4 3 0 0 3 3 3 1 Importin-beta N-terminal domain Adaptin_N PF01602.15 ESL12217.1 - 0.014 13.7 0.7 0.4 8.9 0.0 2.4 3 0 0 3 3 3 0 Adaptin N terminal region HEAT_EZ PF13513.1 ESL12217.1 - 0.015 15.8 0.2 10 6.7 0.0 3.9 3 0 0 3 3 3 0 HEAT-like repeat RIX1 PF08167.7 ESL12217.1 - 0.05 13.2 0.0 0.81 9.3 0.0 2.9 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Xpo1 PF08389.7 ESL12217.1 - 0.055 13.3 0.8 0.9 9.4 0.0 3.4 5 0 0 5 5 5 0 Exportin 1-like protein MAD PF05557.8 ESL12218.1 - 0.0033 15.6 6.6 0.0033 15.6 4.6 2.5 2 1 0 2 2 1 1 Mitotic checkpoint protein TPR_MLP1_2 PF07926.7 ESL12218.1 - 0.0044 16.7 7.6 0.0044 16.7 5.3 4.5 2 1 2 4 4 4 1 TPR/MLP1/MLP2-like protein HALZ PF02183.13 ESL12218.1 - 0.07 12.8 0.2 0.07 12.8 0.1 6.0 5 2 2 7 7 7 0 Homeobox associated leucine zipper Methyltrn_RNA_2 PF04013.7 ESL12218.1 - 0.39 10.2 2.4 10 5.6 0.0 3.1 3 0 0 3 3 3 0 Putative SAM-dependent RNA methyltransferase Herpes_BLRF2 PF05812.7 ESL12218.1 - 0.47 10.2 25.6 0.14 11.9 3.4 4.5 3 2 0 3 3 3 0 Herpesvirus BLRF2 protein FliD_C PF07195.7 ESL12218.1 - 1.1 8.5 20.0 0.29 10.4 3.6 4.0 3 3 1 4 4 4 0 Flagellar hook-associated protein 2 C-terminus Apelin PF15360.1 ESL12218.1 - 1.5 9.1 5.9 0.66 10.2 0.4 2.9 2 0 0 2 2 2 0 APJ endogenous ligand Laminin_II PF06009.7 ESL12218.1 - 1.5 8.5 27.8 0.037 13.7 2.6 4.1 2 1 2 4 4 4 0 Laminin Domain II GAS PF13851.1 ESL12218.1 - 3.5 6.7 46.4 0.22 10.6 5.5 4.6 3 2 1 4 4 4 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 ESL12218.1 - 3.6 7.1 62.5 0.43 10.1 3.3 4.7 3 2 1 4 4 4 0 IncA protein BLOC1_2 PF10046.4 ESL12218.1 - 4 7.6 25.2 1.5 8.9 1.3 5.0 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.6 ESL12218.1 - 5.3 6.9 9.0 6.7 6.6 0.3 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) PMP22_Claudin PF00822.15 ESL12219.1 - 2.3e-05 24.1 9.1 3e-05 23.7 6.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Amastin PF07344.6 ESL12219.1 - 3.9e-05 23.3 19.2 5.3e-05 22.8 11.1 2.0 1 1 1 2 2 2 1 Amastin surface glycoprotein Claudin_2 PF13903.1 ESL12219.1 - 0.0039 16.8 10.7 0.0039 16.8 7.4 2.0 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF3040 PF11239.3 ESL12219.1 - 7.4 6.7 7.7 0.5 10.4 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Rota_NS6 PF04866.7 ESL12222.1 - 0.026 14.5 0.2 0.9 9.5 0.0 2.3 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 zf-RNPHF PF08080.7 ESL12222.1 - 0.058 12.9 0.2 14 5.2 0.0 2.5 2 0 0 2 2 2 0 RNPHF zinc finger NIF PF03031.13 ESL12223.1 - 1.5e-31 109.2 0.1 2e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.21 ESL12223.1 - 0.13 12.6 0.0 1.8 8.9 0.0 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DUF705 PF05152.7 ESL12223.1 - 0.15 10.9 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) CTP_transf_1 PF01148.15 ESL12224.1 - 0.67 9.5 13.1 0.85 9.2 9.1 1.2 1 0 0 1 1 1 0 Cytidylyltransferase family DUF3816 PF12822.2 ESL12224.1 - 6.8 6.5 11.2 47 3.8 7.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) ATP-synt_ab PF00006.20 ESL12225.1 - 1.2e-69 234.0 0.1 1.7e-69 233.6 0.1 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESL12225.1 - 0.009 16.4 0.1 0.031 14.7 0.0 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain RNase_PH PF01138.16 ESL12226.1 - 1.5e-06 28.5 0.0 2.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESL12226.1 - 3.6e-05 23.6 0.1 8.4e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 LIM PF00412.17 ESL12227.1 - 1.9e-07 31.0 5.7 5.4e-06 26.3 2.2 2.5 3 0 0 3 3 3 2 LIM domain DUF3323 PF11796.3 ESL12227.1 - 0.11 11.8 0.1 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) zf-C2H2_7 PF15269.1 ESL12227.1 - 1 9.2 7.0 1.9 8.3 2.3 2.5 2 0 0 2 2 2 0 Zinc-finger NRDE-2 PF08424.5 ESL12228.1 - 0.00038 19.4 0.6 0.00038 19.4 0.4 3.1 3 1 0 3 3 3 1 NRDE-2, necessary for RNA interference SIS_2 PF13580.1 ESL12228.1 - 0.058 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 SIS domain DUF4201 PF13870.1 ESL12229.1 - 5.2e-41 140.0 19.7 5.2e-41 140.0 13.6 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4201) DUF948 PF06103.6 ESL12229.1 - 0.04 13.7 5.1 0.74 9.7 0.4 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.7 ESL12229.1 - 0.04 13.7 1.8 0.21 11.4 0.7 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.1 ESL12229.1 - 0.06 13.6 0.7 0.06 13.6 0.5 4.1 4 2 2 6 6 6 0 Snapin/Pallidin ATG16 PF08614.6 ESL12229.1 - 5.3 6.8 35.7 0.041 13.7 6.9 3.5 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) SlyX PF04102.7 ESL12229.1 - 7.5 7.0 19.3 9.7 6.6 0.1 5.1 5 0 0 5 5 5 0 SlyX SQS_PSY PF00494.14 ESL12230.1 - 3.8e-12 46.0 0.6 6.7e-12 45.2 0.1 1.5 1 1 0 1 1 1 1 Squalene/phytoene synthase TFIIS_C PF01096.13 ESL12231.1 - 1.9e-17 62.6 10.9 3.5e-17 61.7 7.0 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.9 ESL12231.1 - 7.2e-11 42.1 0.0 2.2e-10 40.5 0.0 1.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Baculo_LEF5_C PF11792.3 ESL12231.1 - 0.12 11.7 2.3 0.21 10.9 1.6 1.4 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Baculo_11_kDa PF06143.6 ESL12231.1 - 0.49 9.7 8.4 0.9 8.9 5.9 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family PEX11 PF05648.9 ESL12232.1 - 0.00013 21.3 3.6 0.093 11.9 0.1 2.1 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Evr1_Alr PF04777.8 ESL12233.1 - 8.4e-15 54.4 0.0 1.7e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Erv1 / Alr family DUF2296 PF10058.4 ESL12233.1 - 0.059 13.1 0.0 4.8 7.0 0.0 2.5 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) ArfGap PF01412.13 ESL12234.1 - 9.3e-41 138.2 0.1 9.3e-41 138.2 0.1 1.6 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Nucleoporin_FG PF13634.1 ESL12234.1 - 0.0058 16.8 0.9 0.011 15.8 0.6 1.4 1 0 0 1 1 1 1 Nucleoporin FG repeat region MORN PF02493.15 ESL12235.1 - 7.8e-52 170.0 84.1 3.6e-06 26.3 0.3 12.8 14 0 0 14 14 14 12 MORN repeat Kringle PF00051.13 ESL12235.1 - 3.6 7.7 0.0 3.6 7.7 0.0 4.1 5 0 0 5 5 5 0 Kringle domain