# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF605 PF04652.11 ESS54877.1 - 0.65 9.3 11.2 0.76 9.1 7.8 1.0 1 0 0 1 1 1 0 Vta1 like Galactosyl_T PF01762.16 ESS54878.1 - 8.8e-09 35.2 0.0 0.0015 18.1 0.0 3.6 4 0 0 4 4 4 3 Galactosyltransferase BNR_3 PF13859.1 ESS54879.1 - 1.8e-76 257.1 1.0 3.8e-76 256.1 0.7 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54879.1 - 4.9e-15 56.1 0.4 1.1e-14 54.9 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54879.1 - 3.9e-10 39.4 6.2 8.5e-10 38.3 4.3 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS54879.1 - 0.018 14.3 0.0 0.26 10.5 0.0 2.3 2 1 0 2 2 2 0 BNR repeat-like domain LAP1C PF05609.7 ESS54879.1 - 0.64 8.6 3.1 0.96 8.0 2.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) zf-Di19 PF05605.7 ESS54880.1 - 1.9 8.6 9.4 0.28 11.3 3.2 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding SelB-wing_1 PF09105.5 ESS54881.1 - 0.057 13.0 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix BNR_3 PF13859.1 ESS54883.1 - 1.6e-62 211.4 0.4 4.9e-62 209.7 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54883.1 - 6.3e-16 58.9 3.5 1.3e-15 57.9 2.5 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54883.1 - 6.5e-09 35.5 12.5 6.5e-09 35.5 8.7 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Suppressor_P21 PF11479.3 ESS54884.1 - 0.085 12.5 0.0 0.085 12.5 0.0 1.1 1 0 0 1 1 1 0 RNA silencing suppressor P21 BNR_3 PF13859.1 ESS54886.1 - 1.2e-107 359.5 1.8 1.6e-107 359.2 1.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain DUF349 PF03993.7 ESS54886.1 - 0.3 11.2 4.7 0.15 12.1 1.7 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) BNR_3 PF13859.1 ESS54887.1 - 2.6e-76 256.6 0.4 2.6e-76 256.6 0.3 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54887.1 - 2.3e-18 66.9 2.1 4.6e-18 65.9 1.2 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54887.1 - 1.9e-08 34.0 10.5 4.3e-08 32.8 7.3 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS54887.1 - 0.0015 17.8 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 2 BNR repeat-like domain IncA PF04156.9 ESS54888.1 - 0.002 17.7 1.2 0.002 17.7 0.8 2.2 2 0 0 2 2 2 1 IncA protein Daxx PF03344.10 ESS54888.1 - 0.13 10.6 30.7 0.16 10.4 21.3 1.1 1 0 0 1 1 1 0 Daxx Family PA26 PF04636.8 ESS54888.1 - 0.77 8.3 4.0 0.91 8.1 2.8 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CDC45 PF02724.9 ESS54888.1 - 4.8 5.0 15.0 5.7 4.8 10.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Rota_VP2 PF05087.7 ESS54888.1 - 5.1 4.8 8.9 6.8 4.4 6.1 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein DDRGK PF09756.4 ESS54888.1 - 5.3 6.4 19.4 8.9 5.6 13.4 1.3 1 0 0 1 1 1 0 DDRGK domain FAM196 PF15265.1 ESS54888.1 - 7.3 5.6 25.1 9.1 5.3 17.4 1.0 1 0 0 1 1 1 0 FAM196 family DUF966 PF06136.8 ESS54888.1 - 9.1 5.5 20.2 12 5.1 14.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) MAD PF05557.8 ESS54890.1 - 0.015 13.4 1.3 0.02 13.0 0.9 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein IFT57 PF10498.4 ESS54890.1 - 0.047 12.4 1.0 0.063 12.0 0.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESS54890.1 - 0.21 10.4 1.0 0.3 9.9 0.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1308 PF07000.6 ESS54891.1 - 0.02 13.5 0.1 0.025 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) Mucin PF01456.12 ESS54892.1 - 6.7e-41 139.4 41.1 1.5e-40 138.2 28.5 1.6 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF1675 PF07897.6 ESS54892.1 - 0.29 10.9 9.9 0.41 10.4 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) ArsD PF06953.6 ESS54892.1 - 0.8 9.8 3.9 0.35 11.0 0.4 1.9 2 1 0 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD WES_acyltransf PF03007.11 ESS54892.1 - 1.2 8.6 6.1 1.6 8.2 4.2 1.1 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain SSP160 PF06933.6 ESS54892.1 - 1.3 6.8 21.5 1.9 6.3 14.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Atrophin-1 PF03154.10 ESS54892.1 - 1.5 6.8 10.5 1.8 6.6 7.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family BNR_3 PF13859.1 ESS54896.1 - 3.9e-76 256.0 2.2 3.9e-76 256.0 1.5 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS54896.1 - 1.1e-09 37.9 10.0 1.1e-09 37.9 6.9 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS54897.1 - 3e-76 256.4 0.5 7.7e-76 255.1 0.3 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54897.1 - 1.1e-16 61.4 1.9 1.1e-16 61.4 1.3 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54897.1 - 1.1e-09 37.9 13.3 3e-09 36.5 9.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4131 PF13567.1 ESS54901.1 - 0.0095 15.3 0.1 0.0095 15.3 0.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4131) DUF1418 PF07214.7 ESS54901.1 - 0.046 13.3 0.0 0.16 11.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) Daxx PF03344.10 ESS54901.1 - 0.63 8.4 45.1 0.85 8.0 31.3 1.2 1 0 0 1 1 1 0 Daxx Family Utp14 PF04615.8 ESS54901.1 - 6.1 4.8 49.1 8.2 4.4 34.1 1.0 1 0 0 1 1 1 0 Utp14 protein DUF2575 PF10837.3 ESS54902.1 - 0.026 14.6 1.9 0.15 12.1 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2575) DUF2786 PF10979.3 ESS54903.1 - 0.057 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) HTH_Tnp_ISL3 PF13542.1 ESS54904.1 - 0.026 13.7 1.0 0.089 11.9 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Tr-sialidase_C PF11052.3 ESS54905.1 - 2.9e-09 36.6 8.4 4.6e-09 35.9 5.8 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Tr-sialidase_C PF11052.3 ESS54909.1 - 3.2e-11 42.8 13.2 7.7e-11 41.6 9.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS54909.1 - 3.2e-10 40.4 0.3 3.2e-10 40.4 0.2 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Gln-synt_C PF00120.19 ESS54911.1 - 3.2e-50 170.7 0.0 4.1e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 ESS54911.1 - 3e-13 49.1 0.0 5.4e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Laminin_G_3 PF13385.1 ESS54913.1 - 6e-16 59.0 0.5 1.5e-15 57.7 0.3 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54913.1 - 5e-10 39.0 9.4 1.4e-09 37.6 6.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal LCAT PF02450.10 ESS54913.1 - 0.18 10.7 0.0 0.35 9.8 0.0 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase RHSP PF07999.6 ESS54915.1 - 7.2e-101 337.9 0.0 9.7e-101 337.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS54915.1 - 0.11 12.6 0.0 0.87 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Tr-sialidase_C PF11052.3 ESS54917.1 - 1.7e-11 43.7 7.7 3.3e-11 42.8 5.3 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS54917.1 - 1.5e-10 41.5 0.3 2.4e-10 40.8 0.0 1.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS54917.1 - 3.2e-05 23.1 0.0 5.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54921.1 - 3.9e-15 56.4 1.0 5.1e-15 56.0 0.7 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54921.1 - 8.5e-08 31.9 6.7 2e-07 30.7 4.6 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Aspzincin_M35 PF14521.1 ESS54921.1 - 0.025 15.0 0.0 0.039 14.4 0.0 1.3 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase zf-ribbon_3 PF13248.1 ESS54922.1 - 8.2 5.7 9.5 6.1 6.1 2.8 2.9 3 1 0 3 3 3 0 zinc-ribbon domain RHSP PF07999.6 ESS54928.1 - 1e-62 212.2 0.0 1e-62 212.2 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein ASF1_hist_chap PF04729.8 ESS54928.1 - 0.1 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 ASF1 like histone chaperone GASA PF02704.9 ESS54929.1 - 2.5 8.1 11.6 0.14 12.1 2.0 3.0 3 0 0 3 3 3 0 Gibberellin regulated protein BNR_3 PF13859.1 ESS54931.1 - 4.7e-27 94.8 0.5 1.2e-26 93.5 0.0 1.9 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54931.1 - 0.00079 19.6 0.1 0.0014 18.8 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily FMN_bind PF04205.9 ESS54931.1 - 0.046 13.8 0.2 0.1 12.7 0.2 1.5 1 0 0 1 1 1 0 FMN-binding domain RVT_1 PF00078.22 ESS54933.1 - 4.9e-19 68.5 0.0 6.5e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ATXN-1_C PF12547.3 ESS54933.1 - 0.049 13.5 0.4 0.45 10.5 0.0 2.5 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator EF1G PF00647.14 ESS54934.1 - 6.7e-15 54.7 0.1 8.4e-15 54.3 0.1 1.1 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain ER-remodelling PF14755.1 ESS54935.1 - 0.034 14.2 0.5 0.042 13.9 0.4 1.1 1 0 0 1 1 1 0 Intracellular membrane remodeller DGF-1_C PF11040.3 ESS54936.1 - 9.9e-50 166.3 1.2 1.9e-49 165.4 0.9 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS54936.1 - 1.8e-13 50.6 0.2 4.1e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Ndc1_Nup PF09531.5 ESS54937.1 - 2.1 6.6 6.4 2.9 6.2 4.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1505 PF07403.6 ESS54939.1 - 0.019 14.9 0.6 0.026 14.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1505) DUF1738 PF08401.6 ESS54939.1 - 0.036 13.8 0.1 0.046 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) Phage_integrase PF00589.17 ESS54940.1 - 0.0071 16.0 0.5 0.022 14.4 0.0 2.0 3 0 0 3 3 3 1 Phage integrase family ACBP PF00887.14 ESS54945.1 - 2e-15 56.2 0.0 5.2e-15 54.8 0.0 1.6 2 0 0 2 2 2 1 Acyl CoA binding protein DUF3259 PF11652.3 ESS54945.1 - 0.077 13.1 0.2 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3259) Peptidase_M8 PF01457.11 ESS54946.1 - 2.8e-94 316.3 0.1 3.4e-94 316.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Ribosomal_L11_N PF03946.9 ESS54948.1 - 5e-14 51.5 0.0 8e-14 50.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 ESS54948.1 - 1.1e-05 25.4 0.0 2.9e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain BNR_3 PF13859.1 ESS54949.1 - 1.1e-22 80.5 0.1 1.1e-22 80.5 0.0 2.7 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54949.1 - 4.3e-17 62.7 0.1 8.1e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54949.1 - 6.8e-10 38.6 5.8 1.3e-09 37.7 4.0 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS54950.1 - 2.2e-150 499.4 19.2 3.9e-150 498.6 13.3 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS54950.1 - 1.6e-49 165.6 2.7 3.1e-49 164.7 1.9 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus RHSP PF07999.6 ESS54952.1 - 4.3e-12 45.3 1.0 4.8e-12 45.2 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein Exo_endo_phos_2 PF14529.1 ESS54953.1 - 2.7e-15 56.0 0.0 4.1e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS54953.1 - 5.2e-12 46.2 0.0 8.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family IFT57 PF10498.4 ESS54954.1 - 0.00084 18.1 1.7 0.0012 17.6 1.2 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF4407 PF14362.1 ESS54954.1 - 0.014 14.3 5.4 0.022 13.7 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_G_3 PF13385.1 ESS54955.1 - 4.2e-16 59.5 0.3 7.5e-16 58.7 0.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54955.1 - 1.1e-11 44.3 6.7 2.3e-11 43.3 4.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS54955.1 - 4.2e-07 29.3 0.0 4.2e-07 29.3 0.0 2.4 3 1 0 3 3 3 1 BNR repeat-like domain RHSP PF07999.6 ESS54957.1 - 9.2e-97 324.3 0.4 1.3e-96 323.9 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DAP3 PF10236.4 ESS54957.1 - 0.058 12.3 0.0 0.09 11.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 BNR_3 PF13859.1 ESS54958.1 - 1.6e-18 66.8 0.0 2.1e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain DUF3720 PF12517.3 ESS54959.1 - 3e-26 91.9 17.4 3e-26 91.9 12.0 4.1 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) Saccharop_dh PF03435.13 ESS54961.1 - 3.7e-07 29.4 0.2 5.3e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Saccharop_dh PF03435.13 ESS54962.1 - 3.5e-07 29.5 0.2 5.3e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase zf-ribbon_3 PF13248.1 ESS54964.1 - 0.45 9.7 5.9 0.51 9.6 0.8 2.8 3 1 0 3 3 3 0 zinc-ribbon domain DUF1517 PF07466.6 ESS54965.1 - 0.033 13.1 0.6 0.038 12.9 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) VanW PF04294.8 ESS54965.1 - 0.42 9.8 2.0 1.1 8.4 1.4 1.7 1 1 0 1 1 1 0 VanW like protein DUF3291 PF11695.3 ESS54966.1 - 0.071 12.5 0.1 0.64 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3291) Rifin_STEVOR PF02009.11 ESS54966.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.5 2 0 0 2 2 2 0 Rifin/stevor family DUF3043 PF11241.3 ESS54966.1 - 8.6 5.9 6.6 7.9 6.0 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3043) DGF-1_C PF11040.3 ESS54967.1 - 2.3e-49 165.1 1.2 2.3e-49 165.1 0.9 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS54967.1 - 1.7e-12 47.1 1.9 1.7e-12 47.1 1.3 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DUP PF00674.13 ESS54968.1 - 0.1 12.5 3.4 0.32 10.9 0.3 2.4 2 0 0 2 2 2 0 DUP family RskA PF10099.4 ESS54969.1 - 0.048 13.4 2.3 0.13 11.9 1.6 1.7 1 0 0 1 1 1 0 Anti-sigma-K factor rskA BNR_3 PF13859.1 ESS54970.1 - 1.8e-43 148.8 0.0 2.6e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS54970.1 - 0.00058 19.2 0.3 0.0053 16.0 0.0 2.3 2 1 1 3 3 3 1 BNR repeat-like domain BNR PF02012.15 ESS54970.1 - 3.1 8.0 13.0 8.4 6.6 0.0 4.9 5 0 0 5 5 5 0 BNR/Asp-box repeat DGF-1_5 PF11038.3 ESS54972.1 - 2e-76 256.8 14.5 2e-76 256.8 10.1 1.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS54972.1 - 4.4e-49 164.2 1.3 8.9e-49 163.3 0.9 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SID-1_RNA_chan PF13965.1 ESS54972.1 - 0.25 9.4 3.4 0.4 8.7 2.4 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1129 PF06570.6 ESS54972.1 - 0.34 10.1 2.0 1.3 8.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) RHSP PF07999.6 ESS54973.1 - 2.3e-45 155.0 0.0 3.1e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS54973.1 - 0.11 11.8 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain Mucin PF01456.12 ESS54975.1 - 4.9e-32 110.6 42.5 9e-31 106.5 29.5 2.5 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF566 PF04484.7 ESS54975.1 - 2.3 7.6 7.0 3.2 7.1 4.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF566) RR_TM4-6 PF06459.7 ESS54975.1 - 3.2 7.5 6.5 4 7.2 4.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.3 ESS54975.1 - 6.9 5.1 6.6 8.6 4.8 4.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3936 PF13072.1 ESS54976.1 - 0.013 14.9 0.6 0.026 13.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3936) IKKbetaNEMObind PF12179.3 ESS54977.1 - 0.082 12.7 0.2 0.23 11.2 0.0 1.8 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain BNR_3 PF13859.1 ESS54982.1 - 2e-63 214.3 0.1 3.1e-63 213.7 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS54982.1 - 2e-11 44.3 0.3 8.4e-11 42.3 0.0 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS54982.1 - 3.4e-05 23.5 9.3 8.6e-05 22.3 6.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS54982.1 - 0.0026 17.1 0.0 0.018 14.3 0.0 2.2 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS54982.1 - 0.014 15.1 2.2 0.18 11.7 0.3 3.2 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS54984.1 - 3.9e-59 200.2 3.3 5.1e-59 199.8 2.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain zf-CCHC_6 PF15288.1 ESS54988.1 - 0.78 9.4 3.6 0.72 9.5 0.9 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 ESS54988.1 - 2.7 7.7 8.3 0.32 10.7 0.3 2.9 3 0 0 3 3 3 0 Zinc knuckle RNase_H PF00075.19 ESS54989.1 - 6.3e-14 52.4 0.0 9.5e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_4 PF13894.1 ESS54989.1 - 0.0077 16.5 4.8 2 8.9 0.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS54989.1 - 0.028 14.7 7.8 1.4 9.3 0.1 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type Phe_ZIP PF08916.6 ESS54989.1 - 0.029 14.6 0.0 0.078 13.3 0.0 1.7 1 0 0 1 1 1 0 Phenylalanine zipper UPF0547 PF10571.4 ESS54989.1 - 0.049 13.3 0.8 0.34 10.6 0.0 2.7 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-Di19 PF05605.7 ESS54989.1 - 0.83 9.8 6.4 3.2 7.9 4.5 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 ESS54989.1 - 0.87 9.9 6.5 2.7 8.4 1.2 2.9 2 0 0 2 2 2 0 Zinc-finger double domain EBP50_C-term PF09007.6 ESS54990.1 - 0.029 14.2 0.2 0.13 12.1 0.1 2.2 3 0 0 3 3 3 0 EBP50, C-terminal BNR_3 PF13859.1 ESS54991.1 - 2.2e-131 437.5 4.0 3.4e-131 436.9 2.8 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS54991.1 - 0.0035 16.6 0.0 0.0052 16.1 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Beta_helix PF13229.1 ESS54994.1 - 0.00095 18.9 0.6 0.08 12.6 0.0 2.8 2 1 0 2 2 2 2 Right handed beta helix region Herpes_UL73 PF03554.8 ESS54994.1 - 0.13 12.0 1.8 1 9.2 1.4 2.2 1 1 1 2 2 2 0 UL73 viral envelope glycoprotein RHSP PF07999.6 ESS54995.1 - 6.8e-28 97.4 0.1 8.2e-28 97.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein IFT57 PF10498.4 ESS54997.1 - 0.15 10.7 1.0 0.22 10.2 0.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 zf-Sec23_Sec24 PF04810.10 ESS54997.1 - 0.74 9.4 4.4 16 5.1 0.1 2.6 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-CCHC_3 PF13917.1 ESS54997.1 - 9 6.1 10.8 2.9 7.7 4.8 2.1 2 0 0 2 2 2 0 Zinc knuckle DUF2633 PF11119.3 ESS54999.1 - 0.0069 16.0 1.0 0.0069 16.0 0.7 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2633) Methyltransf_16 PF10294.4 ESS55000.1 - 7e-10 38.6 0.0 6.4e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase MTS PF05175.9 ESS55000.1 - 3.1e-09 36.4 0.0 5.1e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 ESS55000.1 - 0.00069 20.1 0.0 0.0014 19.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS55000.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain BNR_3 PF13859.1 ESS55001.1 - 2.1e-111 371.9 5.7 3.6e-111 371.1 4.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55001.1 - 0.007 15.6 0.1 0.012 14.9 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55005.1 - 1e-47 162.7 4.7 1.4e-47 162.2 3.3 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55005.1 - 7.7e-11 42.4 0.4 3.3e-10 40.4 0.0 2.2 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS55005.1 - 3.6e-06 26.4 0.0 1.7e-05 24.2 0.0 1.8 1 1 1 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55005.1 - 4.2e-06 26.5 7.1 4.2e-06 26.5 4.9 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS55005.1 - 0.025 14.3 0.8 0.025 14.3 0.6 3.2 3 0 0 3 3 3 0 BNR/Asp-box repeat BLUF PF04940.7 ESS55005.1 - 0.078 12.7 0.0 11 5.8 0.0 2.6 3 0 0 3 3 3 0 Sensors of blue-light using FAD Pkinase PF00069.20 ESS55006.1 - 7.4e-48 162.9 0.0 9.3e-48 162.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS55006.1 - 1.6e-28 99.5 0.0 1.9e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase BNR_3 PF13859.1 ESS55007.1 - 7.4e-58 196.0 0.7 1.5e-57 195.0 0.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55007.1 - 2.3e-15 57.1 0.1 5.6e-15 55.9 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55007.1 - 3.2e-10 39.6 10.4 6.2e-10 38.7 7.2 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Colicin_C PF12106.3 ESS55008.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Colicin C terminal ribonuclease domain Tr-sialidase_C PF11052.3 ESS55010.1 - 2.1e-05 24.3 1.1 5.1e-05 23.0 0.8 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55012.1 - 1.4e-67 228.0 0.3 1.4e-67 228.0 0.2 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55012.1 - 3.5e-13 50.0 0.4 1.1e-12 48.4 0.3 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55012.1 - 9.2e-11 41.4 11.1 1.9e-10 40.3 7.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal EBP50_C-term PF09007.6 ESS55015.1 - 0.03 14.1 0.2 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 EBP50, C-terminal PyrI_C PF02748.10 ESS55016.1 - 0.012 14.9 2.0 0.63 9.5 0.1 2.9 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.1 ESS55016.1 - 0.018 15.3 14.8 0.23 11.8 1.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS55016.1 - 0.037 14.3 16.4 0.23 11.8 1.9 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESS55016.1 - 0.19 11.9 2.9 2.9 8.1 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 ESS55016.1 - 2.8 8.3 12.2 0.77 10.1 1.4 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.7 ESS55016.1 - 4.2 7.5 11.5 0.91 9.7 4.7 2.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding RHSP PF07999.6 ESS55017.1 - 2.4e-104 349.3 0.0 3.2e-104 348.9 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55017.1 - 0.0021 18.1 0.0 1.1 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 ESS55017.1 - 0.051 12.9 0.1 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain DNA_pol_viral_C PF00336.13 ESS55019.1 - 0.0027 16.9 0.1 0.0058 15.9 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase (viral) C-terminal domain RNase_H PF00075.19 ESS55019.1 - 0.039 14.2 0.0 0.058 13.7 0.0 1.3 1 0 0 1 1 1 0 RNase H Phage_integrase PF00589.17 ESS55022.1 - 0.034 13.8 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family RNase_H PF00075.19 ESS55023.1 - 1.6e-13 51.1 0.0 2.4e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 RNase H EBP50_C-term PF09007.6 ESS55023.1 - 0.095 12.5 0.9 0.21 11.4 0.1 2.0 2 0 0 2 2 2 0 EBP50, C-terminal zf-C2H2 PF00096.21 ESS55023.1 - 0.58 10.6 13.8 1.8 9.0 1.6 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS55023.1 - 1.5 9.2 11.5 10 6.7 1.5 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESS55023.1 - 5.8 7.1 8.5 8 6.7 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding RVT_1 PF00078.22 ESS55024.1 - 1.2e-25 90.1 0.0 1.5e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS55025.1 - 8.6e-08 32.5 0.0 1.4e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 ESS55025.1 - 0.032 14.0 0.0 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like Phe_ZIP PF08916.6 ESS55025.1 - 0.12 12.7 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 Phenylalanine zipper zf-C2H2_4 PF13894.1 ESS55026.1 - 1.6 9.2 6.0 0.58 10.6 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger CAP_N PF01213.14 ESS55026.1 - 3.1 6.9 11.6 0.54 9.5 1.2 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal zf-C2H2 PF00096.21 ESS55026.1 - 5.2 7.6 6.3 1.2 9.5 0.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Peptidase_M8 PF01457.11 ESS55027.1 - 7.4e-125 417.2 0.0 8.7e-125 417.0 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin DUF772 PF05598.6 ESS55027.1 - 0.058 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Transposase domain (DUF772) Thi4 PF01946.12 ESS55027.1 - 0.082 11.9 0.2 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Thi4 family zf-H2C2_2 PF13465.1 ESS55028.1 - 0.013 15.7 6.0 0.27 11.5 1.5 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_jaz PF12171.3 ESS55028.1 - 0.039 14.1 2.6 3.6 7.8 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS55028.1 - 0.21 11.9 8.7 1.6 9.2 0.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESS55028.1 - 0.54 10.4 6.3 1.6 8.9 4.4 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 ESS55028.1 - 1.2 9.1 5.5 3.4 7.6 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS55028.1 - 4.3 7.8 14.3 1.7 9.1 0.9 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type Peptidase_M8 PF01457.11 ESS55029.1 - 6.5e-150 499.9 0.0 8.5e-150 499.5 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESS55029.1 - 0.071 13.0 0.1 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 SprT-like PF10263.4 ESS55029.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 SprT-like family Reprolysin_3 PF13582.1 ESS55029.1 - 0.2 12.2 0.3 0.82 10.2 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Phage_integrase PF00589.17 ESS55033.1 - 0.0008 19.1 0.4 0.0014 18.2 0.3 1.5 1 1 0 1 1 1 1 Phage integrase family LytR_cpsA_psr PF03816.9 ESS55034.1 - 0.037 13.9 0.2 0.064 13.1 0.1 1.4 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain BNR_3 PF13859.1 ESS55035.1 - 8e-31 107.2 1.1 1.3e-30 106.6 0.2 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55035.1 - 3.9e-06 27.1 1.6 7e-06 26.3 1.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3548 PF12068.3 ESS55035.1 - 0.016 14.5 0.2 0.021 14.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3548) RNase_H PF00075.19 ESS55036.1 - 9.5e-09 35.6 0.0 1.5e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_jaz PF12171.3 ESS55036.1 - 0.093 12.8 2.8 4.4 7.5 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Phe_ZIP PF08916.6 ESS55036.1 - 0.095 13.0 0.6 0.2 11.9 0.1 2.0 2 0 0 2 2 2 0 Phenylalanine zipper DAN PF03045.10 ESS55036.1 - 0.12 11.7 0.0 0.12 11.7 0.0 2.5 3 1 0 3 3 3 0 DAN domain zf-Di19 PF05605.7 ESS55036.1 - 0.33 11.1 6.4 1.6 8.9 4.4 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESS55036.1 - 1.2 9.6 16.9 2 8.9 1.0 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS55036.1 - 1.6 9.2 13.6 1.6 9.2 0.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.2 ESS55036.1 - 4.4 7.6 8.2 25 5.2 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 ESS55036.1 - 4.6 7.7 11.5 1.5 9.2 1.2 3.5 3 0 0 3 3 3 0 Zinc-finger double domain RHSP PF07999.6 ESS55037.1 - 5.6e-61 206.4 0.0 6.8e-61 206.1 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55044.1 - 4.9e-64 216.3 0.3 1.1e-63 215.1 0.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55044.1 - 6.1e-15 55.8 0.3 1.5e-14 54.5 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55044.1 - 2e-10 40.3 8.1 4.8e-10 39.1 5.6 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Rpr2 PF04032.11 ESS55045.1 - 0.14 12.0 0.1 0.2 11.5 0.1 1.2 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Laminin_G_3 PF13385.1 ESS55046.1 - 3.1e-13 50.2 0.2 3.1e-13 50.2 0.1 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55046.1 - 3.9e-10 39.4 6.3 8e-10 38.4 3.9 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Tubulin_C PF03953.12 ESS55047.1 - 2.9e-32 111.3 0.1 4e-32 110.9 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain zf-C2H2 PF00096.21 ESS55049.1 - 0.025 14.8 13.7 0.41 11.0 1.6 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS55049.1 - 0.13 12.6 11.3 1.3 9.5 0.9 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS55049.1 - 0.2 12.0 7.9 0.35 11.2 1.5 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_jaz PF12171.3 ESS55049.1 - 0.21 11.8 6.3 5.3 7.3 0.8 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 ESS55049.1 - 1.9 8.6 8.2 4.9 7.3 5.5 1.9 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 ESS55049.1 - 2 8.4 5.1 3.4 7.6 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Beta_helix PF13229.1 ESS55051.1 - 0.098 12.4 0.5 13 5.5 0.2 2.2 1 1 1 2 2 2 0 Right handed beta helix region Alpha_kinase PF02816.13 ESS55052.1 - 1.5e-62 210.6 0.4 1.8e-62 210.3 0.2 1.1 1 0 0 1 1 1 1 Alpha-kinase family UIM PF02809.15 ESS55052.1 - 0.059 12.9 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif BNR_3 PF13859.1 ESS55054.1 - 7.5e-63 212.4 0.2 7.5e-63 212.4 0.1 2.1 3 1 1 4 4 4 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55054.1 - 3.8e-09 36.9 0.1 1.1e-08 35.5 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55055.1 - 7.6e-91 304.4 2.6 7.6e-91 304.4 1.8 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55055.1 - 3.6e-19 69.5 5.3 8e-19 68.4 0.6 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55055.1 - 9e-09 35.0 12.9 9e-09 35.0 8.9 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS55058.1 - 4.7e-32 110.7 38.0 3.6e-28 98.1 26.4 2.3 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF3439 PF11921.3 ESS55058.1 - 0.21 11.3 8.0 0.55 9.9 5.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mito_fiss_reg PF05308.6 ESS55059.1 - 0.081 12.2 1.6 0.12 11.7 1.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Mucin PF01456.12 ESS55060.1 - 4.1e-35 120.6 52.8 4.1e-35 120.6 36.6 5.2 4 2 0 4 4 4 1 Mucin-like glycoprotein Fimbrial_PilY2 PF14481.1 ESS55060.1 - 0.15 11.4 0.1 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 SOG2 PF10428.4 ESS55060.1 - 1.1 7.8 15.0 1.4 7.4 10.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein BNR_3 PF13859.1 ESS55062.1 - 7.1e-129 429.3 3.8 1.7e-128 428.0 2.7 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55062.1 - 5.4e-16 59.2 3.4 1.7e-15 57.5 2.3 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55062.1 - 3.8e-09 36.2 12.5 1.2e-08 34.6 8.7 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RVT_1 PF00078.22 ESS55063.1 - 0.022 14.1 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_M8 PF01457.11 ESS55066.1 - 1.1e-87 294.5 0.4 2.9e-87 293.1 0.3 1.6 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55066.1 - 0.0014 18.4 1.2 0.0032 17.3 0.9 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS55066.1 - 0.04 13.6 0.1 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 Matrixin BNR_3 PF13859.1 ESS55068.1 - 1.7e-56 191.5 5.0 2.3e-56 191.1 3.5 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55070.1 - 4.1e-128 426.8 1.7 4.1e-128 426.8 1.2 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55070.1 - 5.6e-15 55.9 0.3 1.7e-14 54.3 0.2 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55070.1 - 5.5e-10 38.9 9.0 1.3e-09 37.7 6.3 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55072.1 - 7.6e-38 130.3 1.0 1.2e-37 129.6 0.0 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55072.1 - 3.6e-17 63.0 3.1 6.9e-17 62.1 2.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55072.1 - 1.4e-08 34.4 10.1 3e-08 33.3 7.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Glycos_transf_2 PF00535.21 ESS55073.1 - 0.013 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 ESS55073.1 - 0.017 14.8 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family group 2 HAUS4 PF14735.1 ESS55073.1 - 0.033 13.5 0.0 0.046 13.0 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Glyco_tranf_2_2 PF10111.4 ESS55073.1 - 0.036 13.1 0.0 0.71 8.8 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Laminin_G_3 PF13385.1 ESS55074.1 - 1.4e-11 44.8 0.0 3.6e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55074.1 - 2.3e-06 26.9 0.0 3.9e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55074.1 - 4.4e-06 26.4 7.2 8.9e-06 25.4 5.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal GLTSCR1 PF15249.1 ESS55075.1 - 0.047 13.7 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 Glioma tumor suppressor candidate region Actin PF00022.14 ESS55075.1 - 0.05 12.0 0.0 0.06 11.7 0.0 1.2 1 0 0 1 1 1 0 Actin DUF2892 PF11127.3 ESS55076.1 - 1.9 8.4 4.1 2.7 7.8 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) Tr-sialidase_C PF11052.3 ESS55078.1 - 0.00011 21.9 6.1 0.0003 20.6 4.2 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55080.1 - 3.2e-120 400.8 5.9 6.3e-120 399.9 4.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55080.1 - 9.6e-17 61.6 0.5 3.7e-16 59.7 0.3 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55080.1 - 1.1e-09 37.9 11.0 2.4e-09 36.8 7.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M8 PF01457.11 ESS55081.1 - 2.3e-76 257.2 8.7 7.8e-75 252.1 6.0 2.1 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55081.1 - 1.6e-09 37.4 5.3 1.6e-09 37.4 3.7 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3810 PF12725.2 ESS55081.1 - 0.16 10.8 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) RHSP PF07999.6 ESS55085.1 - 3.8e-104 348.7 1.5 3.8e-104 348.7 1.1 2.2 2 1 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS55086.1 - 4.1e-98 328.8 0.2 5.6e-98 328.4 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS55087.1 - 3.6e-63 213.7 0.3 4.8e-63 213.2 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS55087.1 - 0.037 13.4 0.0 0.066 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 ESS55087.1 - 0.058 13.5 0.1 0.91 9.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain RHSP PF07999.6 ESS55088.1 - 1.2e-13 50.4 0.5 2e-13 49.7 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein Herpes_DNAp_acc PF04929.7 ESS55089.1 - 4.8 6.0 7.3 5.6 5.8 5.1 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Mucin PF01456.12 ESS55092.1 - 0.00017 21.3 5.9 0.00017 21.3 4.1 3.8 2 1 1 3 3 3 1 Mucin-like glycoprotein Mucin PF01456.12 ESS55093.1 - 1.4e-34 118.8 52.0 1.4e-34 118.8 36.0 4.4 2 2 0 3 3 3 1 Mucin-like glycoprotein SOG2 PF10428.4 ESS55093.1 - 8.2 4.9 12.8 11 4.4 8.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Laminin_G_3 PF13385.1 ESS55094.1 - 8e-12 45.6 0.1 8e-12 45.6 0.1 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55094.1 - 3.9e-09 36.1 14.8 7.4e-09 35.3 9.7 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2_4 PF13894.1 ESS55098.1 - 0.03 14.6 11.4 0.34 11.3 1.2 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS55098.1 - 0.055 13.7 5.9 0.41 11.0 1.4 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESS55098.1 - 0.055 13.8 16.4 0.15 12.4 1.4 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type UPF0547 PF10571.4 ESS55098.1 - 0.073 12.7 1.9 0.35 10.6 1.3 2.2 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 RNHCP PF12647.2 ESS55098.1 - 0.15 11.9 2.6 0.79 9.5 0.2 2.3 2 0 0 2 2 2 0 RNHCP domain Zn-ribbon_8 PF09723.5 ESS55098.1 - 0.16 11.9 1.1 19 5.3 0.0 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_jaz PF12171.3 ESS55098.1 - 0.5 10.5 5.2 5.3 7.3 0.8 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESS55098.1 - 1.6 8.7 5.3 2.4 8.1 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESS55098.1 - 1.9 8.6 8.5 8.9 6.5 5.9 2.1 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding BNR_3 PF13859.1 ESS55100.1 - 5e-104 347.7 5.2 5e-104 347.7 3.6 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55100.1 - 8.9e-16 58.5 0.1 3.4e-15 56.6 0.1 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55100.1 - 3.1e-08 33.3 11.6 7e-08 32.1 8.0 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal ECM1 PF05782.6 ESS55103.1 - 1.6 7.3 6.5 2.1 6.9 4.5 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) G-patch PF01585.18 ESS55103.1 - 3.2 7.6 6.2 19 5.1 1.6 2.6 1 1 1 2 2 2 0 G-patch domain DGF-1_C PF11040.3 ESS55104.1 - 7.7e-36 121.8 1.9 1.1e-35 121.3 1.3 1.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus PTS_EIIC PF02378.13 ESS55104.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.0 1 0 0 1 1 1 0 Phosphotransferase system, EIIC Laminin_G_3 PF13385.1 ESS55105.1 - 6.4e-18 65.4 0.4 1.5e-17 64.2 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55105.1 - 1.1e-10 41.1 12.1 3e-10 39.7 8.4 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3441 PF11923.3 ESS55106.1 - 0.071 12.6 0.3 0.076 12.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3441) BNR_3 PF13859.1 ESS55107.1 - 2e-93 312.8 2.1 2.5e-93 312.5 1.5 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55107.1 - 0.00082 18.7 0.1 0.0013 18.0 0.0 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Gag_p17 PF00540.13 ESS55108.1 - 6 6.6 7.3 0.41 10.4 0.7 1.9 2 0 0 2 2 2 0 gag gene protein p17 (matrix protein) RHSP PF07999.6 ESS55110.1 - 3.5e-65 220.2 0.0 4.9e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55110.1 - 0.041 14.0 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain RHSP PF07999.6 ESS55111.1 - 8.9e-108 360.6 0.0 8.9e-108 360.6 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein RHINO PF15319.1 ESS55114.1 - 0.0004 20.2 1.9 0.00049 19.9 1.3 1.1 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein RHSP PF07999.6 ESS55115.1 - 5.6e-79 265.7 0.2 7.5e-79 265.3 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55115.1 - 0.18 11.9 0.0 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESS55115.1 - 0.19 11.1 0.1 0.43 9.9 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain BNR_3 PF13859.1 ESS55117.1 - 1.6e-126 421.5 6.4 3.8e-126 420.3 4.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55117.1 - 8.4e-16 58.5 2.3 8.4e-16 58.5 1.6 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55117.1 - 2e-09 37.1 15.2 4.9e-09 35.8 10.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Herpes_UL49_2 PF04823.7 ESS55118.1 - 0.13 12.2 1.7 0.24 11.3 1.2 1.5 1 0 0 1 1 1 0 Herpesvirus UL49 tegument protein Glyco_trans_1_3 PF13528.1 ESS55120.1 - 0.08 12.1 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 MFS_2 PF13347.1 ESS55130.1 - 0.13 10.5 7.9 0.14 10.4 5.4 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein BNR_3 PF13859.1 ESS55132.1 - 5e-127 423.2 0.8 1.2e-126 422.0 0.5 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55132.1 - 2.4e-16 60.3 1.1 9.2e-16 58.4 0.8 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55132.1 - 1.1e-07 31.5 9.2 1.1e-07 31.5 6.4 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS55133.1 - 4e-118 393.6 9.1 4e-118 393.6 6.3 1.6 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS55133.1 - 1.3e-49 165.9 0.5 3.1e-49 164.7 0.4 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS55133.1 - 4e-34 116.8 13.8 4e-34 116.8 9.6 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 C6_DPF PF10170.4 ESS55134.1 - 0.013 15.5 0.5 0.019 14.9 0.3 1.3 1 0 0 1 1 1 0 Cysteine-rich domain CpXC PF14353.1 ESS55134.1 - 0.062 13.2 3.1 0.085 12.8 2.1 1.3 1 0 0 1 1 1 0 CpXC protein DDHD PF02862.12 ESS55134.1 - 0.18 11.5 3.7 0.21 11.3 2.6 1.1 1 0 0 1 1 1 0 DDHD domain LMBR1 PF04791.11 ESS55134.1 - 0.3 9.6 3.2 0.34 9.4 2.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM91_C PF14648.1 ESS55134.1 - 0.3 9.8 3.1 0.37 9.5 2.1 1.0 1 0 0 1 1 1 0 FAM91 C-terminus Paired_CXXCH_1 PF09699.5 ESS55134.1 - 1.5 8.4 6.8 0.3 10.6 1.3 2.2 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-UBR PF02207.15 ESS55134.1 - 3.5 7.4 8.7 16 5.3 6.0 2.0 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Neur_chan_memb PF02932.11 ESS55134.1 - 4.1 7.2 5.5 5.8 6.7 3.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1666 PF07891.7 ESS55134.1 - 8.8 5.6 11.9 3.3 7.0 3.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1666) Peptidase_M8 PF01457.11 ESS55135.1 - 2.1e-73 247.4 11.7 2.8e-72 243.7 8.1 2.0 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55135.1 - 5.5e-11 42.1 2.3 9.8e-11 41.3 1.6 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M13 PF01431.16 ESS55135.1 - 0.019 14.1 0.1 0.043 12.9 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M13 Mucin PF01456.12 ESS55136.1 - 1.8e-39 134.8 52.9 5.6e-26 91.0 22.3 2.1 1 1 1 2 2 2 2 Mucin-like glycoprotein BSP_II PF05432.6 ESS55136.1 - 5.1 6.2 14.8 9.4 5.4 10.3 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Exo_endo_phos_2 PF14529.1 ESS55137.1 - 1.1e-08 34.7 0.0 1.6e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS55137.1 - 2.2e-08 34.3 0.0 2.7e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BNR_3 PF13859.1 ESS55141.1 - 1e-90 304.0 2.2 1.8e-90 303.1 1.5 1.4 1 0 0 1 1 1 1 BNR repeat-like domain ATP_bind_1 PF03029.12 ESS55145.1 - 7.4e-68 228.6 0.1 9.2e-68 228.3 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 ESS55145.1 - 3.7e-06 26.5 0.0 2.6e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRP54 PF00448.17 ESS55145.1 - 4.6e-06 26.2 0.0 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Miro PF08477.8 ESS55145.1 - 1.8e-05 25.2 0.0 0.0021 18.5 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein CbiA PF01656.18 ESS55145.1 - 2e-05 24.0 0.0 3.8e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.1 ESS55145.1 - 2.8e-05 24.1 0.0 7.7e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.1 ESS55145.1 - 3.5e-05 23.5 0.0 5.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS55145.1 - 0.0002 21.0 0.0 0.00057 19.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain SRPRB PF09439.5 ESS55145.1 - 0.00025 20.3 0.0 0.67 9.1 0.0 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_33 PF13671.1 ESS55145.1 - 0.0003 20.6 0.0 0.00061 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 ESS55145.1 - 0.00052 19.7 0.0 0.001 18.7 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESS55145.1 - 0.00066 19.6 0.0 0.0014 18.5 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_30 PF13604.1 ESS55145.1 - 0.00067 19.2 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS55145.1 - 0.0011 19.0 0.0 0.0022 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESS55145.1 - 0.0015 17.9 0.0 0.0031 16.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein PduV-EutP PF10662.4 ESS55145.1 - 0.0016 17.9 0.0 0.016 14.6 0.0 2.4 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 ESS55145.1 - 0.0025 16.6 0.0 0.087 11.5 0.0 2.2 2 0 0 2 2 2 1 ArgK protein Arf PF00025.16 ESS55145.1 - 0.0026 17.0 0.0 0.055 12.6 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.13 ESS55145.1 - 0.0027 16.9 0.0 0.15 11.3 0.0 2.8 3 0 0 3 3 3 1 Ferrous iron transport protein B Zeta_toxin PF06414.7 ESS55145.1 - 0.0029 16.7 0.0 0.0055 15.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin NB-ARC PF00931.17 ESS55145.1 - 0.0035 16.2 0.0 0.0058 15.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.7 ESS55145.1 - 0.0045 16.6 0.0 0.0094 15.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_5 PF07728.9 ESS55145.1 - 0.0068 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) cobW PF02492.14 ESS55145.1 - 0.0087 15.5 0.0 0.13 11.6 0.0 2.2 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 ESS55145.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESS55145.1 - 0.018 15.8 0.0 0.054 14.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain PhoH PF02562.11 ESS55145.1 - 0.026 13.7 0.0 0.063 12.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.4 ESS55145.1 - 0.028 13.4 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.9 ESS55145.1 - 0.029 13.3 0.0 0.075 12.0 0.0 1.7 2 0 0 2 2 2 0 KAP family P-loop domain Sigma54_activat PF00158.21 ESS55145.1 - 0.03 13.8 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.13 ESS55145.1 - 0.031 13.7 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Septin PF00735.13 ESS55145.1 - 0.032 13.2 0.1 0.12 11.3 0.1 1.9 1 1 0 1 1 1 0 Septin DUF258 PF03193.11 ESS55145.1 - 0.034 13.3 0.1 0.46 9.6 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_35 PF14516.1 ESS55145.1 - 0.04 12.5 0.0 0.093 11.3 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain AAA PF00004.24 ESS55145.1 - 0.04 14.1 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.4 ESS55145.1 - 0.062 11.9 0.0 0.099 11.2 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.10 ESS55145.1 - 0.073 12.7 0.1 0.21 11.2 0.1 1.8 1 1 0 1 1 1 0 NTPase AAA_29 PF13555.1 ESS55145.1 - 0.076 12.5 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain APS_kinase PF01583.15 ESS55145.1 - 0.091 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_28 PF13521.1 ESS55145.1 - 0.1 12.5 0.1 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ras PF00071.17 ESS55145.1 - 0.11 11.8 0.0 1.3 8.3 0.0 2.3 2 1 0 2 2 2 0 Ras family DUF746 PF05344.6 ESS55146.1 - 0.055 12.9 0.1 0.29 10.6 0.1 2.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF746) Mucin PF01456.12 ESS55147.1 - 3.3e-32 111.2 40.6 1.8e-30 105.6 28.1 2.4 1 1 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.7 ESS55147.1 - 2.1 6.0 6.7 3.2 5.3 4.6 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3530 PF12048.3 ESS55147.1 - 5.9 5.7 10.3 1.9 7.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) Pex14_N PF04695.8 ESS55147.1 - 6 6.9 13.7 0.049 13.6 1.7 2.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3439 PF11921.3 ESS55147.1 - 7.1 6.4 16.3 1.2 8.9 5.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) RHSP PF07999.6 ESS55148.1 - 1.1e-111 373.6 1.1 1.6e-111 373.0 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS55148.1 - 0.18 11.2 0.0 0.38 10.1 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain RHSP PF07999.6 ESS55151.1 - 7.6e-78 262.0 0.2 1.2e-77 261.4 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS55152.1 - 7.2e-92 308.2 0.0 1.2e-91 307.4 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Bac_transf PF02397.11 ESS55152.1 - 0.12 11.4 0.0 0.26 10.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial sugar transferase DUF4131 PF13567.1 ESS55153.1 - 1.3 8.4 3.8 1.7 7.9 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2826 PF11442.3 ESS55154.1 - 1.4e-62 210.1 6.6 2.5e-62 209.2 4.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) RHSP PF07999.6 ESS55155.1 - 3.6e-36 124.7 0.2 3.6e-36 124.7 0.1 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein YscO PF07321.7 ESS55155.1 - 0.066 13.0 0.2 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Type III secretion protein YscO Tfb2 PF03849.9 ESS55156.1 - 2.4 6.6 6.0 2.1 6.9 0.3 2.1 2 0 0 2 2 2 0 Transcription factor Tfb2 RVT_1 PF00078.22 ESS55157.1 - 0.00042 19.7 0.0 0.00065 19.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Laminin_G_3 PF13385.1 ESS55158.1 - 0.011 16.0 0.0 0.012 15.8 0.0 1.0 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily RVT_1 PF00078.22 ESS55159.1 - 5.1e-15 55.4 0.0 9.1e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS55159.1 - 1.6e-11 44.6 0.0 2.8e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 RNase H Peptidase_M8 PF01457.11 ESS55160.1 - 1.9e-126 422.4 0.3 2.4e-126 422.1 0.2 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_3 PF13582.1 ESS55160.1 - 0.065 13.7 0.2 0.48 10.9 0.0 2.2 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 ESS55160.1 - 0.073 12.9 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF2583 PF10762.4 ESS55161.1 - 0.074 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) Laminin_G_3 PF13385.1 ESS55162.1 - 1.3e-12 48.2 0.1 2.1e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55162.1 - 2.2e-12 46.6 12.2 2.2e-12 46.6 8.5 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2862 PF11061.3 ESS55162.1 - 0.093 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2862) OGFr_III PF04680.8 ESS55162.1 - 0.42 10.8 3.0 0.73 10.0 2.1 1.3 1 0 0 1 1 1 0 Opioid growth factor receptor repeat BNR_3 PF13859.1 ESS55163.1 - 7.3e-28 97.5 0.3 1.4e-27 96.6 0.0 1.5 2 0 0 2 2 2 1 BNR repeat-like domain SSI PF00720.12 ESS55163.1 - 0.087 12.7 0.0 0.18 11.7 0.0 1.6 1 1 0 1 1 1 0 Subtilisin inhibitor-like BNR_3 PF13859.1 ESS55164.1 - 2.1e-26 92.7 0.1 2.7e-26 92.3 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain TFIIA PF03153.8 ESS55166.1 - 0.1 12.4 0.9 0.12 12.2 0.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BNR_3 PF13859.1 ESS55167.1 - 6.6e-126 419.5 3.3 9e-126 419.1 2.3 1.2 1 0 0 1 1 1 1 BNR repeat-like domain VP_N-CPKC PF11475.3 ESS55168.1 - 0.31 10.6 0.1 0.31 10.6 0.0 2.7 3 0 0 3 3 3 0 Virion protein N terminal domain Laminin_G_3 PF13385.1 ESS55170.1 - 3.1e-17 63.2 2.6 4.8e-17 62.6 1.8 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55170.1 - 1.2e-08 34.7 9.3 2.6e-08 33.5 6.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55173.1 - 1.3e-112 375.8 2.9 1.3e-112 375.8 2.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55173.1 - 1.3e-15 58.0 0.7 4e-15 56.4 0.5 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55173.1 - 5e-07 29.4 10.7 1e-06 28.4 7.4 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS55174.1 - 0.012 14.2 0.0 0.017 13.7 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein PE_PPE_C PF12484.3 ESS55174.1 - 0.12 13.3 1.8 0.34 11.8 0.6 2.0 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal BNR_3 PF13859.1 ESS55175.1 - 2.1e-46 158.4 0.4 2.4e-46 158.2 0.3 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55175.1 - 2.8e-06 26.8 0.1 5.1e-06 25.9 0.1 1.3 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS55175.1 - 0.31 11.0 0.3 0.31 11.0 0.2 2.6 3 0 0 3 3 3 0 BNR/Asp-box repeat DGF-1_4 PF11024.3 ESS55176.1 - 8.9e-14 51.6 2.2 2.5e-13 50.2 1.6 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS55177.1 - 2.3e-51 171.5 2.0 3.7e-51 170.9 1.4 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS55177.1 - 7.7e-22 77.8 3.1 7.7e-22 77.8 2.2 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 SID-1_RNA_chan PF13965.1 ESS55177.1 - 0.2 9.8 4.8 0.29 9.2 3.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 YjgP_YjgQ PF03739.9 ESS55181.1 - 0.077 11.7 4.7 0.091 11.4 3.3 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Tic20 PF09685.5 ESS55181.1 - 0.11 12.5 3.3 0.13 12.2 2.3 1.2 1 0 0 1 1 1 0 Tic20-like protein O-antigen_lig PF13425.1 ESS55181.1 - 0.14 12.1 5.4 0.18 11.7 3.8 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4131 PF13567.1 ESS55181.1 - 0.32 10.3 6.1 0.43 9.9 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) YfhO PF09586.5 ESS55181.1 - 0.54 8.2 8.4 0.58 8.1 5.8 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Ribosomal_S30 PF04758.9 ESS55183.1 - 0.15 11.8 0.5 0.21 11.3 0.4 1.4 1 1 0 1 1 1 0 Ribosomal protein S30 DUF3676 PF12429.3 ESS55184.1 - 4.7e-108 360.1 44.2 7.2e-108 359.4 30.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Laminin_G_3 PF13385.1 ESS55184.1 - 9.6e-10 38.9 1.2 9.6e-10 38.9 0.9 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55184.1 - 2.4e-07 30.4 4.4 3.8e-07 29.8 3.1 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RVT_1 PF00078.22 ESS55189.1 - 2.8e-16 59.5 0.0 3.9e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS55189.1 - 0.019 14.8 0.2 0.095 12.5 0.1 2.2 2 0 0 2 2 2 0 EBP50, C-terminal zf-C2H2_jaz PF12171.3 ESS55190.1 - 0.065 13.4 5.0 3.7 7.7 1.0 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESS55190.1 - 0.3 11.5 19.8 0.56 10.6 1.6 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESS55190.1 - 1.5 9.2 12.6 0.48 10.8 1.5 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS55190.1 - 1.6 9.2 17.8 2.3 8.7 2.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger BNR_3 PF13859.1 ESS55192.1 - 1.8e-29 102.7 0.6 3.6e-29 101.8 0.2 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Peptidase_C37 PF05416.7 ESS55193.1 - 0.04 12.2 0.2 0.046 12.0 0.2 1.0 1 0 0 1 1 1 0 Southampton virus-type processing peptidase POX PF07526.6 ESS55193.1 - 0.16 12.1 1.9 0.21 11.7 1.3 1.1 1 0 0 1 1 1 0 Associated with HOX BNR_3 PF13859.1 ESS55194.1 - 8.3e-10 38.2 0.1 1.9e-09 37.0 0.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55195.1 - 8.8e-40 136.6 2.5 1.3e-39 136.1 0.1 2.3 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55195.1 - 5e-18 65.8 0.4 1.5e-17 64.2 0.3 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55195.1 - 2.2e-09 36.9 13.8 4.7e-09 35.9 9.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS55200.1 - 5.9e-14 52.0 51.9 4.4e-09 36.2 14.9 2.7 1 1 1 2 2 2 2 Mucin-like glycoprotein DUF3561 PF12084.3 ESS55202.1 - 9.3 6.1 7.1 0.4 10.5 0.7 1.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3561) Laminin_G_3 PF13385.1 ESS55203.1 - 2.2e-17 63.7 0.8 4.8e-17 62.6 0.5 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55203.1 - 4.5e-09 36.0 12.5 9.2e-09 35.0 8.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Tr-sialidase_C PF11052.3 ESS55205.1 - 2.1e-10 40.2 6.6 5.3e-10 38.9 4.0 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS55205.1 - 7e-09 36.1 0.4 2.1e-08 34.5 0.1 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4046 PF13255.1 ESS55205.1 - 0.043 12.5 0.0 0.062 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4046) FTA2 PF13095.1 ESS55206.1 - 0.025 14.1 0.3 0.031 13.8 0.2 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RHSP PF07999.6 ESS55209.1 - 1.4e-27 96.3 1.2 1.2e-26 93.3 0.0 2.0 2 0 0 2 2 2 2 Retrotransposon hot spot protein Transposase_20 PF02371.11 ESS55211.1 - 0.069 13.2 0.3 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family BNR_3 PF13859.1 ESS55212.1 - 4.4e-40 137.6 0.4 5.9e-40 137.2 0.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55213.1 - 8.4e-16 58.6 0.5 1.8e-15 57.5 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55213.1 - 5.7e-11 42.0 11.1 1.3e-10 40.9 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Herpes_LMP1 PF05297.6 ESS55213.1 - 0.89 8.4 8.8 1.5 7.6 6.1 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) EGF_2 PF07974.8 ESS55214.1 - 4.8 7.4 14.7 28 4.9 10.2 2.3 1 1 0 1 1 1 0 EGF-like domain Peptidase_M8 PF01457.11 ESS55215.1 - 2.8e-149 497.8 0.1 3.7e-149 497.4 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.1 ESS55215.1 - 0.034 14.0 0.1 0.056 13.3 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 ESS55215.1 - 0.05 14.1 1.4 0.2 12.1 0.1 2.3 2 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Thi4 PF01946.12 ESS55215.1 - 0.1 11.6 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Thi4 family BNR_3 PF13859.1 ESS55216.1 - 1.4e-129 431.6 5.7 1.4e-129 431.6 3.9 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55216.1 - 4.5e-15 56.2 1.0 4.5e-15 56.2 0.7 2.1 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55216.1 - 1.1e-11 44.3 10.5 1.1e-11 44.3 7.3 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF1180 PF06679.7 ESS55216.1 - 0.08 12.8 0.7 0.32 10.8 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Phage_int_SAM_4 PF13495.1 ESS55218.1 - 0.0088 16.3 0.1 0.045 14.0 0.0 2.2 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_integrase PF00589.17 ESS55218.1 - 0.024 14.2 0.7 0.31 10.7 0.1 2.4 2 1 0 2 2 2 0 Phage integrase family zf-H2C2_2 PF13465.1 ESS55221.1 - 0.08 13.2 5.9 1.1 9.6 1.2 2.8 2 0 0 2 2 2 0 Zinc-finger double domain Trm112p PF03966.11 ESS55221.1 - 0.24 11.8 2.2 1.5 9.2 0.4 2.6 2 2 0 2 2 2 0 Trm112p-like protein zf-Di19 PF05605.7 ESS55221.1 - 0.4 10.8 7.6 1.2 9.2 5.2 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESS55221.1 - 1.2 9.6 15.4 0.99 9.8 2.3 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESS55221.1 - 1.2 9.3 6.3 1.8 8.7 0.3 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS55221.1 - 1.6 9.2 9.8 4.7 7.7 1.2 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESS55221.1 - 4.4 7.3 5.6 8.8 6.3 0.1 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger RNase_H PF00075.19 ESS55222.1 - 1.2e-11 45.0 0.0 1.8e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 RNase H PyrI_C PF02748.10 ESS55222.1 - 0.045 13.1 1.5 2.2 7.7 0.0 2.9 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.3 ESS55222.1 - 0.15 12.2 3.9 5.9 7.1 0.6 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DAN PF03045.10 ESS55222.1 - 0.19 11.1 2.6 0.24 10.8 0.0 2.3 2 0 0 2 2 2 0 DAN domain zf-C2H2 PF00096.21 ESS55222.1 - 0.23 11.8 17.6 0.48 10.8 1.9 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS55222.1 - 1.8 9.0 15.8 1.2 9.6 1.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESS55222.1 - 4.7 7.4 10.7 0.9 9.7 4.2 2.2 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 ESS55222.1 - 5.9 7.3 11.7 1.4 9.3 1.5 3.4 3 0 0 3 3 3 0 Zinc-finger double domain BNR_3 PF13859.1 ESS55223.1 - 1.3e-129 431.6 3.4 2.5e-129 430.8 2.3 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55223.1 - 1.6e-16 60.9 0.5 1.6e-16 60.9 0.3 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55223.1 - 1.5e-11 43.9 12.1 1.5e-11 43.9 8.4 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Herpes_LMP1 PF05297.6 ESS55223.1 - 3.1 6.6 9.7 9.6 5.0 6.7 1.8 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DGF-1_5 PF11038.3 ESS55227.1 - 7.9e-159 527.1 18.6 7.9e-159 527.1 12.9 2.6 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS55227.1 - 6.4e-44 147.7 2.6 7.7e-44 147.4 0.6 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS55227.1 - 2.1e-37 127.3 17.4 5.7e-37 125.9 12.1 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Laminin_G_3 PF13385.1 ESS55229.1 - 0.0036 17.5 0.1 0.0045 17.2 0.1 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3676 PF12429.3 ESS55230.1 - 1.7e-95 319.0 29.9 2.5e-95 318.4 20.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS55230.1 - 7.5e-08 32.1 6.7 1.4e-07 31.2 4.7 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal HTH_Tnp_4 PF13613.1 ESS55230.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HpaP PF09483.5 ESS55230.1 - 3.2 7.6 9.1 0.94 9.3 3.9 1.8 2 0 0 2 2 2 0 Type III secretion protein (HpaP) DGF-1_C PF11040.3 ESS55231.1 - 3.1e-47 158.3 0.5 5.9e-47 157.4 0.4 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS55231.1 - 4.6e-11 42.4 1.2 4.6e-11 42.4 0.9 1.7 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 PepSY_TM_2 PF13703.1 ESS55231.1 - 0.87 9.8 12.2 6.2 7.0 0.0 4.0 3 1 1 4 4 4 0 PepSY-associated TM helix Orbi_NS3 PF01616.11 ESS55231.1 - 1.7 7.5 4.3 0.77 8.6 0.1 2.1 2 1 1 3 3 3 0 Orbivirus NS3 DGF-1_4 PF11024.3 ESS55232.1 - 1.7e-40 137.2 16.9 4.3e-40 135.9 11.7 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Exo_endo_phos_2 PF14529.1 ESS55233.1 - 4.2e-16 58.6 0.0 8.2e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS55233.1 - 1.5e-11 44.7 0.0 2.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.22 ESS55234.1 - 3.5e-21 75.5 0.0 4.2e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.17 ESS55235.1 - 0.00074 19.2 0.3 0.0014 18.3 0.0 1.6 2 0 0 2 2 2 1 Phage integrase family IFT57 PF10498.4 ESS55236.1 - 0.0051 15.6 1.3 0.0068 15.1 0.9 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESS55236.1 - 0.02 13.8 2.6 0.028 13.3 1.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4407 PF14362.1 ESS55236.1 - 0.025 13.5 1.5 0.031 13.2 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HR1 PF02185.11 ESS55236.1 - 0.033 13.9 3.6 0.12 12.0 2.5 1.9 1 1 0 1 1 1 0 Hr1 repeat BCNT PF07572.7 ESS55238.1 - 0.096 12.6 0.5 0.33 10.9 0.0 2.1 3 0 0 3 3 3 0 Bucentaur or craniofacial development Mucin PF01456.12 ESS55240.1 - 6.2e-42 142.7 50.9 4.2e-27 94.6 22.0 2.0 1 1 1 2 2 2 2 Mucin-like glycoprotein PIH1 PF08190.7 ESS55240.1 - 7.4 5.9 7.0 13 5.0 4.8 1.3 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 BSP_II PF05432.6 ESS55240.1 - 7.9 5.6 14.0 14 4.8 9.7 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) zf-CCHC_6 PF15288.1 ESS55241.1 - 2 8.1 5.8 1.7 8.4 2.3 2.0 2 0 0 2 2 2 0 Zinc knuckle DDHD PF02862.12 ESS55242.1 - 0.75 9.5 3.7 0.83 9.4 2.6 1.0 1 0 0 1 1 1 0 DDHD domain RNase_H PF00075.19 ESS55244.1 - 1e-08 35.5 0.0 1.7e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS55244.1 - 0.043 13.2 1.4 0.14 11.5 0.0 2.4 2 0 0 2 2 2 0 DAN domain Phe_ZIP PF08916.6 ESS55244.1 - 0.08 13.2 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 Phenylalanine zipper RVT_1 PF00078.22 ESS55245.1 - 5.7e-14 51.9 0.0 8.5e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS55245.1 - 0.017 14.9 0.2 0.11 12.4 0.1 2.4 3 0 0 3 3 3 0 EBP50, C-terminal Mucin PF01456.12 ESS55248.1 - 6e-25 87.6 39.5 7.1e-25 87.4 27.4 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF1675 PF07897.6 ESS55248.1 - 0.03 14.1 4.7 0.034 14.0 3.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Pex14_N PF04695.8 ESS55248.1 - 0.56 10.2 6.1 0.62 10.1 4.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cyto_heme_lyase PF01265.12 ESS55248.1 - 0.75 9.3 4.9 0.91 9.0 3.4 1.0 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase MCPVI PF02993.9 ESS55248.1 - 1.6 8.8 6.2 1.8 8.6 4.3 1.0 1 0 0 1 1 1 0 Minor capsid protein VI DUF3484 PF11983.3 ESS55248.1 - 7.4 7.4 7.9 12 6.7 5.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3484) VCBS PF13517.1 ESS55249.1 - 6.5e-15 55.2 12.5 0.00023 21.4 1.0 5.9 4 2 2 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 ESS55249.1 - 3.3e-11 42.5 20.7 0.19 11.4 0.1 6.9 7 0 0 7 7 7 5 FG-GAP repeat PQQ_2 PF13360.1 ESS55249.1 - 6.7e-08 32.2 0.0 1.2e-05 24.9 0.0 2.4 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.1 ESS55249.1 - 6.7e-06 26.2 5.3 0.13 12.5 0.4 5.1 5 0 0 5 5 5 2 PQQ-like domain TcdB_toxin_midN PF12256.3 ESS55249.1 - 6.1e-05 22.5 4.0 1 8.7 0.1 5.0 4 1 1 5 5 5 2 Insecticide toxin TcdB middle/N-terminal region Neisseria_PilC PF05567.6 ESS55249.1 - 0.0073 15.3 0.3 0.16 10.9 0.0 2.9 2 1 1 3 3 3 1 Neisseria PilC beta-propeller domain BNR_3 PF13859.1 ESS55251.1 - 1.5e-132 441.4 6.7 1.5e-132 441.4 4.7 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55251.1 - 4.8e-20 72.3 0.9 1.5e-19 70.7 0.6 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55251.1 - 4.8e-09 35.9 15.6 4.8e-09 35.9 10.8 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55253.1 - 1.5e-31 109.6 1.2 1.1e-30 106.7 0.1 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55253.1 - 1.1e-17 64.6 1.4 2.6e-17 63.4 1.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55253.1 - 3.7e-11 42.6 9.4 7.9e-11 41.6 6.5 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal SCIMP PF15050.1 ESS55257.1 - 0.073 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 SCIMP protein Laminin_G_3 PF13385.1 ESS55258.1 - 0.066 13.4 0.0 0.075 13.2 0.0 1.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55259.1 - 8e-32 110.5 0.4 8e-32 110.5 0.3 1.9 2 1 1 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55259.1 - 1.1e-16 61.4 2.2 1.9e-16 60.6 1.5 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55259.1 - 1.2e-08 34.7 10.1 2.5e-08 33.6 7.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3676 PF12429.3 ESS55261.1 - 1.1e-105 352.3 45.9 1.6e-105 351.8 31.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS55261.1 - 2.7e-10 39.9 6.0 4.6e-10 39.1 4.2 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55266.1 - 5.1e-64 216.2 2.4 1.1e-63 215.2 0.6 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55266.1 - 3.7e-17 63.0 1.3 1e-16 61.5 0.9 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55266.1 - 1.5e-05 24.7 11.9 1.5e-05 24.7 8.2 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS55267.1 - 5.8e-19 68.0 0.1 4.9e-18 64.9 0.0 2.0 1 1 1 2 2 2 2 Retrotransposon hot spot protein Galactosyl_T PF01762.16 ESS55271.1 - 5.8e-07 29.2 0.0 0.03 13.9 0.0 3.5 4 0 0 4 4 4 2 Galactosyltransferase GIDE PF12483.3 ESS55276.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 E3 Ubiquitin ligase Molybdop_Fe4S4 PF04879.11 ESS55276.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Fe4S4 domain Mucin PF01456.12 ESS55279.1 - 1.1e-37 129.0 40.4 1.9e-37 128.1 28.0 1.4 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF4366 PF14283.1 ESS55279.1 - 0.098 12.0 0.1 0.098 12.0 0.0 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) BRF1 PF07741.8 ESS55279.1 - 0.37 11.0 3.6 0.52 10.5 2.5 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Menin PF05053.8 ESS55279.1 - 0.48 8.5 6.0 0.6 8.2 4.1 1.1 1 0 0 1 1 1 0 Menin SOG2 PF10428.4 ESS55279.1 - 3.3 6.2 11.9 4.3 5.8 8.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein zf-C2H2_jaz PF12171.3 ESS55280.1 - 0.18 11.9 3.6 3.4 7.9 0.5 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 ESS55280.1 - 0.34 11.0 6.6 1.4 9.1 4.6 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 ESS55280.1 - 8.5 6.9 15.9 5.3 7.6 1.5 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger IFT57 PF10498.4 ESS55282.1 - 0.00086 18.1 0.7 0.0011 17.8 0.5 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESS55282.1 - 0.019 13.8 0.9 0.026 13.4 0.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 ESS55282.1 - 0.084 11.5 0.3 0.11 11.1 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESS55282.1 - 0.23 10.3 5.3 0.29 10.0 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BNR_3 PF13859.1 ESS55284.1 - 1.2e-29 103.4 0.2 2.8e-29 102.2 0.1 1.6 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55285.1 - 7.8e-87 291.2 1.3 9.4e-87 290.9 0.9 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55285.1 - 0.0022 17.3 0.0 0.0031 16.8 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55286.1 - 6.3e-119 396.6 2.8 7.8e-119 396.3 1.9 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55286.1 - 2.6e-05 23.6 0.1 3.3e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain DGF-1_C PF11040.3 ESS55290.1 - 3.4e-47 158.2 1.2 6.4e-47 157.3 0.8 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS55290.1 - 9.5e-17 61.1 5.9 2.3e-16 59.9 4.1 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Laminin_G_3 PF13385.1 ESS55292.1 - 6e-07 29.8 0.0 9.3e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Dynein_heavy PF03028.10 ESS55292.1 - 0.076 11.0 0.0 0.1 10.6 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor DUF3005 PF11448.3 ESS55292.1 - 0.079 12.5 0.1 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) Metallothio_5 PF02067.10 ESS55293.1 - 0.01 15.8 4.5 0.01 15.8 3.1 2.8 2 1 0 2 2 2 0 Metallothionein family 5 vMSA PF00695.14 ESS55294.1 - 3.2 6.8 8.0 4 6.5 5.6 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Macoilin PF09726.4 ESS55295.1 - 8.6 4.5 19.6 11 4.1 13.6 1.2 1 0 0 1 1 1 0 Transmembrane protein Mucin PF01456.12 ESS55296.1 - 3e-24 85.4 26.4 3.5e-24 85.1 18.3 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF1675 PF07897.6 ESS55296.1 - 0.11 12.3 0.5 0.12 12.1 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) TMEM154 PF15102.1 ESS55296.1 - 0.37 10.4 7.6 0.4 10.3 5.3 1.1 1 0 0 1 1 1 0 TMEM154 protein family SSP160 PF06933.6 ESS55296.1 - 0.38 8.6 18.8 0.38 8.6 13.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MGC-24 PF05283.6 ESS55296.1 - 2.6 7.8 18.9 2.9 7.6 13.1 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Lamp PF01299.12 ESS55296.1 - 3.3 6.7 11.2 3.7 6.6 7.8 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) gpUL132 PF11359.3 ESS55296.1 - 9.4 5.4 13.0 10 5.3 9.0 1.1 1 0 0 1 1 1 0 Glycoprotein UL132 RHSP PF07999.6 ESS55300.1 - 5.5e-84 282.2 0.4 7.6e-84 281.8 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55300.1 - 0.0014 18.7 0.0 0.42 10.7 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_10 PF12846.2 ESS55300.1 - 0.095 12.1 0.0 0.53 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain DUF966 PF06136.8 ESS55301.1 - 0.15 11.4 5.0 0.19 11.1 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BNR_3 PF13859.1 ESS55302.1 - 1.5e-29 103.0 0.3 1.9e-29 102.7 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain CENP-N PF05238.8 ESS55303.1 - 0.025 13.6 0.2 0.25 10.3 0.2 2.0 1 1 0 1 1 1 0 Kinetochore protein CHL4 like Tr-sialidase_C PF11052.3 ESS55304.1 - 5e-11 42.2 8.7 1.3e-10 40.9 6.0 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS55304.1 - 8.4e-11 42.3 0.1 1.6e-10 41.4 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.18 ESS55304.1 - 0.082 12.9 0.1 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 Laminin G domain Peptidase_M8 PF01457.11 ESS55307.1 - 4.3e-90 302.5 0.3 5.5e-90 302.1 0.2 1.0 1 0 0 1 1 1 1 Leishmanolysin RskA PF10099.4 ESS55309.1 - 0.33 10.6 6.6 0.99 9.1 4.6 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Peptidase_M8 PF01457.11 ESS55311.1 - 1.6e-30 105.9 9.3 6e-29 100.7 6.5 2.0 1 1 0 1 1 1 1 Leishmanolysin Mucin PF01456.12 ESS55313.1 - 1.4e-39 135.1 37.5 3.9e-39 133.6 26.0 1.7 1 1 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.7 ESS55313.1 - 0.0043 14.9 9.8 0.0052 14.6 6.8 1.0 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein DUF2413 PF10310.4 ESS55313.1 - 0.034 12.9 1.4 0.039 12.7 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) SSP160 PF06933.6 ESS55313.1 - 0.044 11.7 15.3 0.06 11.3 10.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3591 PF12157.3 ESS55313.1 - 0.14 10.5 0.6 0.17 10.2 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3591) Tir_receptor_C PF07489.6 ESS55313.1 - 0.73 9.5 14.1 1.2 8.7 9.8 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Sporozoite_P67 PF05642.6 ESS55313.1 - 1.1 6.9 13.5 1.4 6.6 9.4 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3720 PF12517.3 ESS55314.1 - 1.5e-21 76.8 11.1 1.5e-21 76.8 7.7 4.4 1 1 4 5 5 5 1 Protein of unknown function (DUF3720) Biliv-reduc_cat PF09166.5 ESS55315.1 - 0.055 13.4 0.1 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Biliverdin reductase, catalytic BNR_3 PF13859.1 ESS55316.1 - 8.6e-25 87.4 0.1 1.5e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55316.1 - 8.6e-09 35.8 0.3 2.5e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RNase_H PF00075.19 ESS55317.1 - 4.2e-10 40.0 0.0 7.4e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.22 ESS55317.1 - 0.00016 21.1 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS55317.1 - 0.073 12.9 0.1 0.28 11.0 0.1 2.0 1 0 0 1 1 1 0 EBP50, C-terminal zf-C2H2 PF00096.21 ESS55317.1 - 9.5 6.8 15.6 2.3 8.7 1.6 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type DNA_pol_viral_C PF00336.13 ESS55318.1 - 0.033 13.4 0.1 0.091 12.0 0.0 1.8 1 1 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Spc7 PF08317.6 ESS55321.1 - 0.087 11.4 1.5 0.14 10.7 1.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESS55321.1 - 0.18 10.7 12.6 0.033 13.1 6.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Mucin PF01456.12 ESS55324.1 - 3.2e-25 88.5 26.5 4.2e-25 88.1 18.4 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Nop14 PF04147.7 ESS55324.1 - 0.041 11.8 0.2 0.047 11.6 0.1 1.0 1 0 0 1 1 1 0 Nop14-like family SSP160 PF06933.6 ESS55324.1 - 0.17 9.8 18.6 0.24 9.3 12.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Pex14_N PF04695.8 ESS55324.1 - 0.4 10.7 8.6 0.053 13.5 2.4 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Menin PF05053.8 ESS55324.1 - 3 5.9 5.2 3.2 5.7 3.6 1.1 1 0 0 1 1 1 0 Menin TMEM154 PF15102.1 ESS55324.1 - 4.5 6.9 10.3 6.5 6.4 7.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family Dicty_REP PF05086.7 ESS55324.1 - 9.4 3.8 11.8 12 3.5 8.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-C2H2_4 PF13894.1 ESS55327.1 - 0.24 11.8 11.3 2.4 8.6 1.2 2.9 2 1 1 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS55327.1 - 0.3 11.4 6.6 1.5 9.2 1.0 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-Di19 PF05605.7 ESS55327.1 - 0.31 11.1 8.0 0.85 9.7 5.6 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 ESS55327.1 - 0.37 11.0 6.2 5.1 7.3 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding BNR_3 PF13859.1 ESS55330.1 - 2.1e-25 89.4 0.0 8.4e-19 67.7 0.1 2.3 1 1 1 2 2 2 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55330.1 - 1.2e-12 48.3 0.0 3.5e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55330.1 - 8.3e-05 22.3 10.2 0.00017 21.3 7.1 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55333.1 - 1.3e-104 349.6 3.3 1.3e-104 349.6 2.3 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55333.1 - 1.5e-15 57.7 3.1 1.8e-15 57.4 0.9 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55333.1 - 3.2e-12 46.0 9.5 6.8e-12 45.0 6.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF1180 PF06679.7 ESS55333.1 - 7.8 6.3 6.4 0.75 9.6 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) RNase_H PF00075.19 ESS55334.1 - 5.7e-08 33.1 0.0 9.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS55334.1 - 0.093 12.1 0.0 0.093 12.1 0.0 2.6 3 0 0 3 3 3 0 DAN domain UPF0547 PF10571.4 ESS55334.1 - 0.31 10.7 0.1 0.31 10.7 0.1 3.2 3 1 0 3 3 3 0 Uncharacterised protein family UPF0547 zf-H2C2_2 PF13465.1 ESS55334.1 - 5.3 7.5 8.6 8.2 6.9 1.2 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS55334.1 - 9.9 6.7 15.1 1.3 9.4 1.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger RHSP PF07999.6 ESS55335.1 - 2.4e-119 398.8 0.0 4.4e-119 397.9 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein S-methyl_trans PF02574.11 ESS55335.1 - 0.054 12.7 0.2 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Homocysteine S-methyltransferase AAA_17 PF13207.1 ESS55335.1 - 0.11 13.3 0.2 10 6.9 0.1 3.6 3 1 0 3 3 3 0 AAA domain DGF-1_C PF11040.3 ESS55336.1 - 2.1e-49 165.3 1.4 3.4e-49 164.6 0.9 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS55336.1 - 1e-21 77.3 3.0 1e-21 77.3 2.0 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 BNR_3 PF13859.1 ESS55339.1 - 1.8e-48 165.2 0.0 2.7e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55339.1 - 7.3e-15 55.5 0.6 2.2e-14 53.9 0.4 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55339.1 - 1.6e-07 31.0 3.1 3.8e-07 29.8 2.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS55339.1 - 0.0096 15.6 3.2 3.4 7.8 0.1 4.0 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_3 PF13859.1 ESS55343.1 - 7.3e-17 61.3 0.0 1.1e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Cuticle_1 PF08140.6 ESS55343.1 - 0.3 10.9 1.4 7.5 6.4 0.0 3.6 5 0 0 5 5 5 0 Crustacean cuticle protein repeat DGF-1_C PF11040.3 ESS55345.1 - 4.1e-50 167.5 1.3 4.1e-50 167.5 0.9 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS55345.1 - 1.1e-28 100.2 3.5 1.1e-28 100.2 2.5 2.7 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS55345.1 - 9.9e-25 86.7 12.8 2.3e-24 85.5 8.9 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF605 PF04652.11 ESS55347.1 - 2.7 7.2 8.1 3.3 7.0 5.6 1.1 1 0 0 1 1 1 0 Vta1 like Galactosyl_T PF01762.16 ESS55348.1 - 3.2e-06 26.9 0.0 0.013 15.0 0.0 3.3 4 0 0 4 4 4 2 Galactosyltransferase Tachystatin_B PF11478.3 ESS55348.1 - 0.13 12.0 0.1 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B RVT_1 PF00078.22 ESS55349.1 - 0.0053 16.1 0.0 0.0073 15.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.20 ESS55350.1 - 3.2e-40 137.9 0.0 4.1e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS55350.1 - 1.2e-19 70.4 0.0 1.4e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS55350.1 - 0.0014 17.6 0.0 0.0057 15.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like BNR_3 PF13859.1 ESS55353.1 - 1.7e-65 221.1 0.2 2.9e-65 220.3 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55353.1 - 5.5e-15 55.9 0.5 1.2e-14 54.8 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55353.1 - 4.4e-07 29.6 9.8 8.6e-07 28.7 6.8 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Alginate_exp PF13372.1 ESS55353.1 - 0.0017 17.0 0.0 0.0026 16.4 0.0 1.2 1 0 0 1 1 1 1 Alginate export BNR_3 PF13859.1 ESS55354.1 - 3.8e-44 150.9 0.4 5.5e-44 150.4 0.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain DUF3508 PF12018.3 ESS55357.1 - 0.54 9.1 7.0 0.71 8.8 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3508) DNA_processg_A PF02481.10 ESS55359.1 - 0.082 11.7 0.1 0.18 10.7 0.0 1.7 1 1 0 1 1 1 0 DNA recombination-mediator protein A RuvC PF02075.12 ESS55359.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Crossover junction endodeoxyribonuclease RuvC Phage_integrase PF00589.17 ESS55360.1 - 0.0015 18.2 0.2 0.0036 16.9 0.1 1.7 1 1 0 1 1 1 1 Phage integrase family IFT57 PF10498.4 ESS55361.1 - 0.0033 16.2 0.5 0.0041 15.9 0.3 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Spc7 PF08317.6 ESS55361.1 - 0.12 10.9 0.3 0.17 10.5 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ATP-synt_D PF01813.12 ESS55361.1 - 0.15 11.5 0.7 0.23 11.0 0.5 1.1 1 0 0 1 1 1 0 ATP synthase subunit D DUF4407 PF14362.1 ESS55361.1 - 0.26 10.2 9.5 0.34 9.8 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.3 ESS55361.1 - 0.9 9.5 4.5 1.3 9.0 2.7 1.5 1 1 0 1 1 1 0 YlqD protein BNR_3 PF13859.1 ESS55362.1 - 8.9e-59 199.0 4.4 1.5e-58 198.2 3.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Peptidase_C2 PF00648.16 ESS55362.1 - 0.044 12.7 0.1 0.062 12.2 0.1 1.2 1 0 0 1 1 1 0 Calpain family cysteine protease Septum_form PF13845.1 ESS55363.1 - 0.0074 15.8 1.8 0.0089 15.5 1.2 1.0 1 0 0 1 1 1 1 Septum formation BNR_3 PF13859.1 ESS55364.1 - 3.7e-132 440.0 5.1 5.8e-132 439.4 3.6 1.3 1 0 0 1 1 1 1 BNR repeat-like domain XhlA PF10779.4 ESS55368.1 - 3.5 7.5 12.6 2 8.4 0.5 3.3 2 1 1 3 3 3 0 Haemolysin XhlA BNR_3 PF13859.1 ESS55369.1 - 9.6e-18 64.2 0.1 1.6e-17 63.6 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Rib_hydrolayse PF02267.12 ESS55369.1 - 0.0087 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyl cyclase MAD PF05557.8 ESS55372.1 - 0.066 11.2 3.2 0.094 10.7 2.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein IFT57 PF10498.4 ESS55372.1 - 0.32 9.6 3.8 0.13 11.0 1.0 1.4 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 SRP-alpha_N PF04086.8 ESS55373.1 - 2.5 7.4 13.1 3.7 6.8 9.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DPM3 PF08285.6 ESS55374.1 - 0.53 10.1 3.0 1 9.2 0.8 2.2 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) BNR_3 PF13859.1 ESS55375.1 - 1.1e-127 425.3 4.0 1.1e-127 425.3 2.8 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55375.1 - 3.6e-15 56.5 1.4 1.2e-14 54.8 0.8 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55375.1 - 1.4e-10 40.8 14.8 3.9e-10 39.4 10.3 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Alginate_exp PF13372.1 ESS55375.1 - 0.028 13.0 0.1 0.082 11.5 0.0 1.7 1 1 1 2 2 2 0 Alginate export DUF4407 PF14362.1 ESS55377.1 - 0.025 13.5 6.7 0.032 13.2 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Myosin_tail_1 PF01576.14 ESS55377.1 - 0.029 12.1 5.2 0.035 11.8 3.6 1.0 1 0 0 1 1 1 0 Myosin tail IFT57 PF10498.4 ESS55377.1 - 0.035 12.8 1.9 0.045 12.4 1.3 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.6 ESS55377.1 - 0.044 12.4 0.9 0.055 12.1 0.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.4 ESS55377.1 - 0.11 11.4 3.1 0.14 11.0 2.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_integrase PF00589.17 ESS55379.1 - 0.0016 18.1 0.4 0.0024 17.5 0.2 1.7 1 1 0 1 1 1 1 Phage integrase family RVT_1 PF00078.22 ESS55380.1 - 0.064 12.5 0.0 0.22 10.8 0.0 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) BNR_3 PF13859.1 ESS55383.1 - 3.2e-129 430.4 3.3 5.6e-129 429.6 2.3 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55383.1 - 1.4e-09 37.6 3.9 4.4e-09 36.0 2.7 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Phage_integrase PF00589.17 ESS55384.1 - 0.0021 17.7 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family BNR_3 PF13859.1 ESS55385.1 - 1.2e-100 336.5 7.3 1.8e-100 336.0 5.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Nucleoplasmin PF03066.10 ESS55386.1 - 0.71 9.3 5.6 0.97 8.9 3.9 1.2 1 0 0 1 1 1 0 Nucleoplasmin FA_desaturase PF00487.19 ESS55387.1 - 0.029 13.8 0.2 0.04 13.3 0.1 1.2 1 0 0 1 1 1 0 Fatty acid desaturase Cytochrom_B558a PF05038.8 ESS55387.1 - 0.094 12.3 0.5 0.18 11.4 0.4 1.4 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit IncA PF04156.9 ESS55387.1 - 9.2 5.8 7.7 19 4.7 5.3 1.5 1 0 0 1 1 1 0 IncA protein DUF1360 PF07098.6 ESS55390.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zf-ribbon_3 PF13248.1 ESS55390.1 - 1.3 8.2 4.5 1.8 7.8 0.3 2.6 3 0 0 3 3 3 0 zinc-ribbon domain Laminin_G_3 PF13385.1 ESS55391.1 - 2.5e-13 50.5 0.1 6.3e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55391.1 - 1.5e-12 47.1 9.0 2.8e-12 46.2 6.3 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_1 PF00054.18 ESS55391.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain Laminin_G_2 PF02210.19 ESS55391.1 - 0.024 14.6 0.1 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain BNR_3 PF13859.1 ESS55394.1 - 1.1e-38 133.0 0.0 1.4e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55394.1 - 2.5e-06 27.0 0.7 7.4e-06 25.4 0.5 1.5 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS55394.1 - 0.017 14.8 2.2 0.24 11.3 0.4 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat Laminin_G_3 PF13385.1 ESS55395.1 - 3.9e-08 33.6 0.0 6.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Dynein_heavy PF03028.10 ESS55395.1 - 0.0069 14.4 0.0 0.0086 14.1 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF2575 PF10837.3 ESS55398.1 - 0.053 13.6 0.5 0.77 9.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2575) Phage_integrase PF00589.17 ESS55400.1 - 0.00046 19.9 0.2 0.004 16.8 0.0 2.1 2 0 0 2 2 2 1 Phage integrase family DGF-1_5 PF11038.3 ESS55403.1 - 2.2e-162 538.8 18.6 2.6e-162 538.5 12.9 1.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS55403.1 - 3.7e-33 113.7 20.5 3.7e-33 113.7 14.2 1.7 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS55404.1 - 8.2e-36 121.7 1.8 1.3e-35 121.1 1.3 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4381 PF14316.1 ESS55404.1 - 0.041 14.0 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Vpu PF00558.14 ESS55404.1 - 0.79 9.3 2.4 1.9 8.0 1.6 1.8 1 1 0 1 1 1 0 Vpu protein RHSP PF07999.6 ESS55405.1 - 5.3e-80 269.1 0.8 8.5e-80 268.4 0.6 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55405.1 - 0.0086 16.2 0.0 6.5 6.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain SPC25 PF06703.6 ESS55406.1 - 0.032 13.8 0.1 0.037 13.6 0.1 1.1 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DNA_pol_viral_C PF00336.13 ESS55410.1 - 0.055 12.7 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain CDRT4 PF15213.1 ESS55412.1 - 0.055 13.5 0.2 0.25 11.4 0.2 2.0 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein HrpB2 PF09487.5 ESS55412.1 - 0.13 12.4 2.2 0.18 11.9 0.6 1.8 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) DUF2457 PF10446.4 ESS55413.1 - 0.045 12.4 3.7 0.05 12.3 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF605 PF04652.11 ESS55413.1 - 3.2 7.0 12.0 3.9 6.7 8.3 1.1 1 0 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS55415.1 - 2.7e-131 437.2 6.3 5.9e-131 436.1 4.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55415.1 - 8.8e-11 41.4 6.8 2.4e-10 40.0 4.7 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal OrfB_Zn_ribbon PF07282.6 ESS55416.1 - 0.16 11.6 0.8 0.24 11.1 0.6 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DGF-1_5 PF11038.3 ESS55417.1 - 1.7e-134 447.3 21.7 1.7e-134 447.3 15.1 1.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS55417.1 - 1.8e-41 139.8 0.6 4.9e-41 138.4 0.4 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SID-1_RNA_chan PF13965.1 ESS55417.1 - 1.4 7.0 6.0 2.3 6.2 4.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BNR_3 PF13859.1 ESS55418.1 - 2.3e-130 434.2 3.9 2.8e-130 433.9 2.7 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Vac7 PF12751.2 ESS55418.1 - 0.014 14.2 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 P12 PF12669.2 ESS55419.1 - 0.061 13.5 0.9 0.1 12.8 0.6 1.4 1 0 0 1 1 1 0 Virus attachment protein p12 family Mucin PF01456.12 ESS55420.1 - 0.0041 16.8 6.7 0.0041 16.8 4.6 2.4 2 2 0 2 2 2 1 Mucin-like glycoprotein Ferric_reduct PF01794.14 ESS55422.1 - 0.38 10.8 5.4 0.5 10.4 3.7 1.1 1 0 0 1 1 1 0 Ferric reductase like transmembrane component DUF4131 PF13567.1 ESS55422.1 - 1.5 8.1 8.9 1.8 7.9 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) zf-4CXXC_R1 PF10497.4 ESS55425.1 - 0.7 10.0 4.6 0.82 9.8 0.3 2.3 3 0 0 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Peptidase_M8 PF01457.11 ESS55426.1 - 7.4e-42 143.3 10.9 3e-40 138.0 7.5 2.1 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55426.1 - 7.4e-09 35.3 14.7 1.4e-08 34.4 10.2 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS55427.1 - 1.4e-19 70.5 17.8 1.4e-19 70.5 12.3 4.0 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) DUF3225 PF11533.3 ESS55429.1 - 0.16 11.6 2.0 0.18 11.4 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3225) BNR_3 PF13859.1 ESS55430.1 - 1.1e-128 428.6 1.9 2.6e-128 427.4 1.3 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55430.1 - 2.2e-14 54.0 1.5 5.2e-14 52.7 0.2 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55430.1 - 1.8e-10 40.5 12.6 5.4e-10 38.9 8.8 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55431.1 - 1.9e-86 289.9 2.2 3.6e-86 289.0 1.5 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55431.1 - 1.2e-17 64.6 0.2 4.8e-17 62.6 0.2 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55431.1 - 1.4e-09 37.6 16.7 3.4e-09 36.3 11.6 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal CDK5_activator PF03261.10 ESS55433.1 - 0.23 10.7 2.8 22 4.2 2.5 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein EF1G PF00647.14 ESS55435.1 - 2.8e-09 36.6 0.0 3.6e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain DUF2180 PF09947.4 ESS55435.1 - 0.0088 15.7 0.3 0.012 15.3 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2180) RHSP PF07999.6 ESS55436.1 - 8.3e-108 360.7 0.2 1.3e-107 360.1 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55438.1 - 6.1e-132 439.3 4.0 1.2e-131 438.4 2.8 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55438.1 - 1.8e-10 40.4 12.2 1.8e-10 40.4 8.5 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal CCSMST1 PF15013.1 ESS55440.1 - 0.014 15.2 0.2 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 CCSMST1 family CoA_binding_3 PF13727.1 ESS55440.1 - 0.12 12.2 4.8 0.14 11.9 3.3 1.1 1 0 0 1 1 1 0 CoA-binding domain TMEM247 PF15444.1 ESS55440.1 - 2.4 7.9 5.1 2.8 7.6 3.5 1.1 1 0 0 1 1 1 0 Transmembrane protein 247 Phage_integrase PF00589.17 ESS55441.1 - 0.003 17.2 0.1 0.0074 15.9 0.1 1.9 1 1 0 1 1 1 1 Phage integrase family Galactosyl_T PF01762.16 ESS55443.1 - 0.012 15.2 0.1 0.22 11.1 0.0 2.4 1 1 0 1 1 1 0 Galactosyltransferase BNR_3 PF13859.1 ESS55444.1 - 8.4e-128 425.7 3.8 1.6e-127 424.8 2.6 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55444.1 - 1.1e-15 58.2 1.3 3.7e-15 56.5 0.9 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55444.1 - 7.7e-09 35.2 6.3 2.2e-08 33.8 4.4 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55446.1 - 3.4e-24 85.4 0.2 4.5e-24 85.0 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55447.1 - 8.8e-100 333.7 1.7 1.1e-99 333.4 1.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55447.1 - 0.0012 18.1 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55449.1 - 6.9e-127 422.7 4.5 6.9e-127 422.7 3.1 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55449.1 - 8.5e-16 58.5 0.6 8.5e-16 58.5 0.4 2.3 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55449.1 - 1.1e-11 44.3 12.2 1.1e-11 44.3 8.5 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PPV_E2_N PF00508.12 ESS55451.1 - 0.014 14.6 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 E2 (early) protein, N terminal LCE PF14672.1 ESS55453.1 - 6.2 7.3 12.2 0.53 10.8 1.6 2.2 2 0 0 2 2 2 0 Late cornified envelope CASP_C PF08172.7 ESS55455.1 - 0.079 11.9 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 CASP C terminal RHSP PF07999.6 ESS55457.1 - 1.1e-45 156.0 0.0 1.5e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3720 PF12517.3 ESS55463.1 - 8.9e-26 90.4 20.8 8.9e-26 90.4 14.4 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3720) Nop14 PF04147.7 ESS55463.1 - 0.0028 15.6 6.2 0.0035 15.3 4.3 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 ESS55463.1 - 0.46 8.4 6.5 0.47 8.4 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.4 ESS55463.1 - 2.4 6.3 7.7 3 6.0 5.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Hid1 PF12722.2 ESS55463.1 - 8.9 3.8 6.7 11 3.5 4.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM176 PF14851.1 ESS55463.1 - 9.3 5.9 7.1 18 5.0 4.9 1.5 1 0 0 1 1 1 0 FAM176 family BNR_3 PF13859.1 ESS55464.1 - 2.9e-131 437.1 3.8 5.3e-131 436.3 2.6 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55464.1 - 1.1e-15 58.1 0.7 3.7e-15 56.5 0.5 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55464.1 - 2.7e-10 39.9 11.1 2.7e-10 39.9 7.7 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Herpes_LMP1 PF05297.6 ESS55464.1 - 2.2 7.1 8.8 4.8 5.9 6.1 1.5 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RNase_H PF00075.19 ESS55466.1 - 1.5e-13 51.2 0.0 2.2e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS55466.1 - 0.0098 15.3 0.1 0.0098 15.3 0.0 1.8 2 0 0 2 2 2 1 DAN domain RHSP PF07999.6 ESS55467.1 - 3.1e-07 29.3 1.9 8.2e-07 27.9 0.1 2.0 2 0 0 2 2 2 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55469.1 - 5.1e-65 219.5 0.6 5.1e-65 219.5 0.4 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55469.1 - 1.8e-20 73.7 0.5 3.9e-20 72.6 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55469.1 - 7.1e-10 38.5 11.2 7.1e-10 38.5 7.8 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55470.1 - 6e-56 189.7 1.7 8.8e-56 189.2 1.2 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF966 PF06136.8 ESS55472.1 - 2.4 7.4 15.1 3.4 6.9 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BNR_3 PF13859.1 ESS55473.1 - 2.5e-29 102.3 0.1 2.5e-29 102.3 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55473.1 - 3.4e-18 66.3 0.3 3.4e-18 66.3 0.2 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55473.1 - 3.7e-11 42.6 13.2 6.8e-11 41.8 9.1 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Exo_endo_phos_2 PF14529.1 ESS55474.1 - 9.1e-17 60.7 0.0 1.9e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS55474.1 - 3.2e-14 53.4 0.0 6.3e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Laminin_G_3 PF13385.1 ESS55474.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55475.1 - 4.6e-27 94.9 0.1 8.2e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55475.1 - 3.1e-16 59.9 0.5 5.4e-16 59.2 0.4 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55475.1 - 1.5e-09 37.5 9.7 3.7e-09 36.2 6.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS55475.1 - 0.091 12.7 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain BNR_3 PF13859.1 ESS55476.1 - 7e-70 235.5 0.3 8.7e-70 235.2 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS55477.1 - 4.6e-13 48.5 2.0 5.2e-13 48.3 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS55478.1 - 3e-64 217.2 0.1 5.1e-64 216.4 0.0 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF1633 PF07794.6 ESS55479.1 - 0.027 12.4 0.6 0.03 12.3 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Tweety PF04906.8 ESS55480.1 - 0.036 12.4 6.8 0.038 12.3 4.7 1.1 1 0 0 1 1 1 0 Tweety RHSP PF07999.6 ESS55481.1 - 3.2e-42 144.6 0.0 5e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3676 PF12429.3 ESS55483.1 - 2.3e-14 53.5 0.1 3.2e-14 53.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Laminin_G_3 PF13385.1 ESS55483.1 - 6.6e-08 32.9 0.3 1e-07 32.3 0.2 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS55484.1 - 9.1e-28 97.0 0.5 1.3e-27 96.5 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55485.1 - 5.1e-66 222.8 0.8 5.1e-66 222.8 0.6 2.3 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55485.1 - 1.5e-10 41.5 0.6 2.9e-10 40.6 0.4 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PEGA PF08308.6 ESS55485.1 - 0.037 13.8 0.9 0.073 12.8 0.1 1.9 2 0 0 2 2 2 0 PEGA domain Mucin PF01456.12 ESS55489.1 - 2.1e-29 102.1 60.0 5.2e-28 97.6 41.6 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein Shisa PF13908.1 ESS55489.1 - 0.0094 16.1 7.7 0.012 15.7 5.4 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Pex14_N PF04695.8 ESS55489.1 - 0.12 12.4 5.5 0.13 12.3 3.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2360 PF10152.4 ESS55489.1 - 0.13 12.5 2.9 0.15 12.3 2.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF1675 PF07897.6 ESS55489.1 - 0.2 11.5 4.9 0.24 11.2 3.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) LAT PF15234.1 ESS55489.1 - 0.46 9.9 7.0 0.66 9.4 4.8 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells MCPVI PF02993.9 ESS55489.1 - 0.7 9.9 5.1 0.82 9.7 3.6 1.1 1 0 0 1 1 1 0 Minor capsid protein VI DUF1180 PF06679.7 ESS55489.1 - 2.4 7.9 11.9 6.1 6.7 8.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3484 PF11983.3 ESS55489.1 - 2.6 8.9 5.1 4.3 8.2 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) PRCC PF10253.4 ESS55489.1 - 2.7 8.6 8.8 3.1 8.4 6.1 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF3530 PF12048.3 ESS55489.1 - 3.2 6.6 13.8 14 4.5 9.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) Dicty_REP PF05086.7 ESS55489.1 - 6.8 4.3 13.9 8.9 3.9 9.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ESSS PF10183.4 ESS55490.1 - 0.081 13.3 1.0 0.13 12.7 0.7 1.3 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF4233 PF14017.1 ESS55490.1 - 2.4 8.1 13.1 0.057 13.3 3.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4233) BNR_3 PF13859.1 ESS55491.1 - 1.4e-134 448.0 4.8 2.6e-134 447.1 3.3 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55491.1 - 7e-18 65.3 0.3 2.9e-17 63.3 0.2 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55491.1 - 5.8e-10 38.8 10.0 1.5e-09 37.5 6.9 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF515 PF04415.7 ESS55491.1 - 2.2 6.3 4.2 3.7 5.6 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) BNR_3 PF13859.1 ESS55494.1 - 4.6e-33 114.6 0.0 9.4e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55494.1 - 6.9e-12 45.8 0.5 2.5e-11 44.0 0.0 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESS55494.1 - 0.35 10.8 3.6 0.8 9.7 0.2 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS55500.1 - 2.9e-54 184.2 0.0 4.3e-54 183.6 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55500.1 - 1.8e-07 31.5 0.1 5.7e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS55500.1 - 0.00019 20.7 0.2 0.004 16.4 0.0 2.2 1 1 1 2 2 2 2 BNR repeat-like domain DUF718 PF05336.8 ESS55500.1 - 0.19 11.5 0.0 0.53 10.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF718) PepSY_TM_1 PF13172.1 ESS55501.1 - 1.2 8.9 4.3 3.1 7.6 0.1 2.5 2 0 0 2 2 2 0 PepSY-associated TM helix DUF605 PF04652.11 ESS55502.1 - 3.5 6.9 10.5 8.4 5.6 7.3 1.5 1 1 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS55503.1 - 1.1e-42 146.2 0.1 1.4e-42 145.8 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Gp_dh_C PF02800.15 ESS55509.1 - 8.1e-43 145.5 0.0 1e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Phage_integrase PF00589.17 ESS55511.1 - 0.03 13.9 0.2 0.064 12.9 0.0 1.6 2 0 0 2 2 2 0 Phage integrase family BNR_3 PF13859.1 ESS55512.1 - 1.2e-131 438.4 5.2 2.3e-131 437.4 3.6 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55512.1 - 7.1e-17 62.0 0.6 2.5e-16 60.3 0.1 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55512.1 - 6.8e-09 35.4 14.1 6.8e-09 35.4 9.8 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Retinin_C PF04527.7 ESS55513.1 - 0.12 12.3 0.6 0.37 10.8 0.4 1.8 1 0 0 1 1 1 0 Drosophila Retinin like protein BNR_3 PF13859.1 ESS55514.1 - 4.2e-134 446.4 5.4 4.2e-134 446.4 3.7 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55514.1 - 3e-19 69.7 3.4 9.4e-19 68.1 2.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55514.1 - 1e-08 34.8 15.1 3.2e-08 33.2 10.5 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55516.1 - 4e-74 249.4 1.4 1.1e-73 247.9 1.0 1.8 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55516.1 - 2.4e-17 63.6 0.3 5.5e-17 62.4 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55516.1 - 3.4e-11 42.7 7.8 6.7e-11 41.8 5.4 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4611 PF15387.1 ESS55516.1 - 0.032 14.3 1.3 0.092 12.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) BNR_3 PF13859.1 ESS55517.1 - 1.7e-20 73.3 0.0 3.3e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Vac7 PF12751.2 ESS55517.1 - 0.13 11.0 0.1 0.19 10.5 0.1 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 TPR_2 PF07719.12 ESS55518.1 - 1e-05 25.0 0.0 2.8e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS55518.1 - 0.00073 19.0 0.0 0.002 17.6 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS55518.1 - 0.0038 17.8 1.6 0.0072 16.9 0.1 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS55518.1 - 0.0049 16.4 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 TPR repeat TPR_6 PF13174.1 ESS55518.1 - 0.0069 16.7 0.0 0.021 15.2 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS55518.1 - 0.039 14.5 0.5 0.15 12.8 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS55518.1 - 0.13 12.5 0.1 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS55518.1 - 0.16 11.8 0.0 0.46 10.4 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS55518.1 - 0.18 11.7 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat ICAM_N PF03921.9 ESS55520.1 - 0.005 16.2 1.1 0.0063 15.9 0.8 1.2 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain RCR PF12273.3 ESS55520.1 - 0.024 15.1 0.0 0.028 14.9 0.0 1.2 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red BNR_3 PF13859.1 ESS55522.1 - 1.2e-128 428.5 4.2 1.2e-128 428.5 2.9 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55522.1 - 5.1e-15 56.0 3.1 8.9e-15 55.2 0.8 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55522.1 - 1.8e-11 43.7 11.1 1.8e-11 43.7 7.7 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55523.1 - 2.2e-89 299.5 6.0 2.9e-89 299.1 4.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55523.1 - 0.00015 21.1 0.2 0.00019 20.8 0.2 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55524.1 - 1.6e-31 109.5 0.1 1.6e-31 109.5 0.1 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55524.1 - 1.3e-18 67.7 1.0 4.5e-18 65.9 0.7 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55524.1 - 8.1e-11 41.5 11.6 1.8e-10 40.5 8.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Acid_PPase PF12689.2 ESS55527.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Acid Phosphatase Herpes_env PF01673.13 ESS55528.1 - 0.047 12.2 1.8 0.052 12.0 1.2 1.0 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Peptidase_S64 PF08192.6 ESS55528.1 - 6.7 4.9 8.8 6.9 4.8 6.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 FLO_LFY PF01698.11 ESS55528.1 - 8.7 5.0 7.2 11 4.8 5.0 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein SLD3 PF08639.5 ESS55528.1 - 9 4.8 12.5 10 4.5 8.7 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 BNR_3 PF13859.1 ESS55529.1 - 3.5e-127 423.7 7.5 5.9e-127 423.0 5.2 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55529.1 - 1.4e-16 61.1 2.4 2.4e-16 60.3 0.7 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55529.1 - 1.6e-10 40.6 11.8 4.8e-10 39.1 8.2 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS55530.1 - 4.1e-164 544.5 19.5 4.1e-164 544.5 13.5 2.4 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS55530.1 - 2e-49 165.3 1.1 2e-49 165.3 0.8 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS55530.1 - 1.4e-30 105.4 14.5 3.4e-30 104.2 10.0 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Phostensin PF13914.1 ESS55531.1 - 0.45 10.6 2.7 1.2 9.2 1.4 2.0 1 1 1 2 2 2 0 Phostensin PP1-binding and SH3-binding region BNR_3 PF13859.1 ESS55533.1 - 7.5e-127 422.6 2.9 7.5e-127 422.6 2.0 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55533.1 - 7e-17 62.0 2.0 1.8e-16 60.7 1.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55533.1 - 2e-08 33.9 12.6 6.8e-08 32.2 8.7 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS55535.1 - 6.7e-16 58.9 1.1 9.9e-16 58.3 0.6 1.4 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55535.1 - 5.6e-11 42.1 11.1 1.3e-10 40.9 7.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55536.1 - 2.7e-130 433.9 7.4 2.7e-130 433.9 5.1 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Clathrin PF00637.15 ESS55536.1 - 0.11 12.0 0.1 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TFIIA PF03153.8 ESS55537.1 - 2.2 8.0 8.8 2.3 8.0 6.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF605 PF04652.11 ESS55537.1 - 5.5 6.2 16.6 6.8 5.9 11.5 1.2 1 0 0 1 1 1 0 Vta1 like DUF4407 PF14362.1 ESS55538.1 - 0.25 10.2 5.4 0.36 9.7 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RHSP PF07999.6 ESS55540.1 - 8.7e-71 238.7 0.3 1.6e-70 237.8 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein Bac_transf PF02397.11 ESS55540.1 - 0.066 12.3 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial sugar transferase DUF2116 PF09889.4 ESS55543.1 - 0.05 13.4 0.2 0.05 13.4 0.2 1.6 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DGF-1_4 PF11024.3 ESS55545.1 - 1.3e-13 51.0 2.2 3.3e-13 49.8 1.5 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS55546.1 - 5.6e-52 173.5 1.7 8.9e-52 172.9 1.2 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS55546.1 - 4.4e-21 75.3 2.8 4.4e-21 75.3 1.9 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 SID-1_RNA_chan PF13965.1 ESS55546.1 - 0.67 8.0 5.5 1 7.4 3.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RHSP PF07999.6 ESS55548.1 - 9.3e-29 100.2 0.1 1.1e-28 100.1 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein zf-C2H2_jaz PF12171.3 ESS55549.1 - 0.035 14.2 3.3 4 7.6 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS55549.1 - 0.17 12.3 9.5 1.5 9.3 0.9 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS55549.1 - 0.19 12.0 6.7 0.6 10.5 1.2 2.7 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESS55549.1 - 0.55 10.6 15.0 0.34 11.3 1.2 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESS55549.1 - 0.62 10.2 6.5 1.9 8.6 4.5 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding RVT_1 PF00078.22 ESS55550.1 - 1.8e-14 53.6 0.1 2.3e-14 53.2 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESS55551.1 - 1.7e-17 63.0 0.0 2.9e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS55551.1 - 2.3e-12 47.4 0.0 6.1e-12 46.0 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RHSP PF07999.6 ESS55554.1 - 1.2e-35 123.0 0.0 1.2e-35 122.9 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_M8 PF01457.11 ESS55555.1 - 3.3e-105 352.3 11.1 2.3e-104 349.6 7.7 1.9 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55555.1 - 2.5e-09 36.8 11.4 2.5e-09 36.8 7.9 3.0 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS55555.1 - 0.045 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Matrixin DUF4131 PF13567.1 ESS55555.1 - 0.3 10.4 0.0 0.3 10.4 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4584 PF15223.1 ESS55556.1 - 0.022 14.0 4.9 0.026 13.8 3.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4584) Mucin PF01456.12 ESS55556.1 - 0.087 12.5 0.6 0.087 12.5 0.4 1.7 1 1 1 2 2 2 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS55557.1 - 2.5e-130 434.1 4.5 3.9e-130 433.4 3.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55557.1 - 3.4e-13 50.1 2.6 5.7e-12 46.1 0.2 2.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55559.1 - 1e-18 67.5 0.1 1.5e-18 66.9 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Rib_hydrolayse PF02267.12 ESS55559.1 - 0.013 14.8 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosyl cyclase DUF566 PF04484.7 ESS55567.1 - 0.039 13.4 2.5 0.043 13.3 1.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF566) DDE_Tnp_1_4 PF13701.1 ESS55567.1 - 0.11 10.6 2.8 0.12 10.5 1.9 1.0 1 0 0 1 1 1 0 Transposase DDE domain group 1 RB_B PF01857.15 ESS55567.1 - 0.9 9.0 4.1 0.75 9.2 0.1 2.0 1 1 1 2 2 2 0 Retinoblastoma-associated protein B domain XAP5 PF04921.9 ESS55567.1 - 1.2 8.6 10.9 2.3 7.7 7.5 1.4 1 1 0 1 1 1 0 XAP5, circadian clock regulator RVT_1 PF00078.22 ESS55568.1 - 1.5e-09 37.5 0.0 2.1e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3714 PF12508.3 ESS55572.1 - 0.14 11.6 6.9 0.19 11.1 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3714) Glyco_transf_15 PF01793.11 ESS55572.1 - 9.3 5.0 9.1 12 4.7 6.3 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Phage_integrase PF00589.17 ESS55574.1 - 0.0012 18.5 0.1 0.0034 17.0 0.0 1.8 2 0 0 2 2 2 1 Phage integrase family Pyrid_oxidase_2 PF13883.1 ESS55578.1 - 0.15 11.8 2.6 0.18 11.5 1.8 1.1 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Zip PF02535.17 ESS55578.1 - 1.4 7.8 4.1 1.7 7.5 2.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC27 PF09507.5 ESS55582.1 - 4.4 6.4 26.2 6.4 5.8 18.2 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nodulin-like PF06813.8 ESS55584.1 - 0.028 13.6 0.4 0.041 13.1 0.3 1.2 1 0 0 1 1 1 0 Nodulin-like BNR_3 PF13859.1 ESS55585.1 - 6.9e-121 403.0 7.9 1.4e-120 402.0 5.5 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55585.1 - 1.3e-09 37.7 10.2 3.3e-09 36.4 7.0 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55587.1 - 3.3e-129 430.4 4.9 3.3e-129 430.4 3.4 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55587.1 - 6.7e-15 55.6 0.2 2.8e-14 53.6 0.1 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55587.1 - 2.8e-10 39.8 11.1 2.8e-10 39.8 7.7 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS55588.1 - 5.1e-117 391.1 6.7 4e-97 325.5 1.3 2.0 1 1 1 2 2 2 2 Retrotransposon hot spot protein DUF2890 PF11081.3 ESS55588.1 - 0.0068 16.4 15.9 0.012 15.6 11.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2890) Daxx PF03344.10 ESS55588.1 - 0.014 13.9 17.4 0.018 13.5 12.0 1.1 1 0 0 1 1 1 0 Daxx Family Spore_coat_CotO PF14153.1 ESS55588.1 - 0.016 14.6 14.0 0.023 14.1 9.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO AIF_C PF14721.1 ESS55588.1 - 0.02 15.1 3.9 0.033 14.4 2.7 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RRN3 PF05327.6 ESS55588.1 - 0.035 12.2 8.7 0.046 11.8 6.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.9 ESS55588.1 - 0.057 11.4 11.6 0.072 11.1 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Merozoite_SPAM PF07133.6 ESS55588.1 - 0.071 13.0 28.2 0.12 12.3 19.6 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Sigma70_ner PF04546.8 ESS55588.1 - 0.13 11.8 16.7 0.21 11.1 11.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF913 PF06025.7 ESS55588.1 - 0.19 10.4 3.5 0.27 9.9 2.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DAP3 PF10236.4 ESS55588.1 - 0.2 10.5 0.0 0.2 10.5 0.0 1.7 2 0 0 2 2 1 0 Mitochondrial ribosomal death-associated protein 3 Nop14 PF04147.7 ESS55588.1 - 0.22 9.3 22.1 0.3 8.9 15.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 ESS55588.1 - 0.24 10.0 20.1 0.43 9.2 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Bud13 PF09736.4 ESS55588.1 - 0.44 10.8 13.5 0.7 10.1 9.4 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF3530 PF12048.3 ESS55588.1 - 0.46 9.4 4.8 0.64 8.9 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Hom_end_hint PF05203.11 ESS55588.1 - 0.46 10.1 2.3 0.84 9.3 1.6 1.5 1 0 0 1 1 1 0 Hom_end-associated Hint CENP-T PF15511.1 ESS55588.1 - 0.53 9.4 9.9 0.72 9.0 6.9 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Ycf1 PF05758.7 ESS55588.1 - 0.54 7.9 10.1 0.66 7.6 7.0 1.1 1 0 0 1 1 1 0 Ycf1 RR_TM4-6 PF06459.7 ESS55588.1 - 0.75 9.6 15.4 1.1 9.1 10.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SUFU_C PF12470.3 ESS55588.1 - 0.83 9.2 4.3 1.4 8.5 3.0 1.3 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain CT47 PF15623.1 ESS55588.1 - 0.93 9.1 28.6 1.6 8.4 19.8 1.3 1 0 0 1 1 1 0 Cancer/testis gene family 47 DDRGK PF09756.4 ESS55588.1 - 0.98 8.7 23.0 1.8 7.9 15.9 1.4 1 0 0 1 1 1 0 DDRGK domain RNA_pol_3_Rpc31 PF11705.3 ESS55588.1 - 1.1 9.1 21.3 1.7 8.5 14.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF1510 PF07423.6 ESS55588.1 - 1.1 8.5 19.0 1.8 7.9 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4359 PF14271.1 ESS55588.1 - 1.9 8.8 4.4 2.4 8.5 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4359) IncA PF04156.9 ESS55588.1 - 2.2 7.8 9.5 3.1 7.3 6.6 1.2 1 0 0 1 1 1 0 IncA protein TRAP_alpha PF03896.11 ESS55588.1 - 2.8 6.8 16.9 3.6 6.5 10.3 1.9 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Pox_Ag35 PF03286.9 ESS55588.1 - 2.8 7.4 14.2 4.5 6.7 9.9 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DDHD PF02862.12 ESS55588.1 - 3.5 7.3 10.2 5.4 6.7 7.1 1.2 1 0 0 1 1 1 0 DDHD domain Usp PF00582.21 ESS55588.1 - 3.8 7.6 9.9 8.2 6.6 6.8 1.6 1 0 0 1 1 1 0 Universal stress protein family NPR3 PF03666.8 ESS55588.1 - 4.3 5.7 5.9 5.8 5.3 4.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Trypan_PARP PF05887.6 ESS55588.1 - 5 6.9 26.4 8.5 6.1 18.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Drc1-Sld2 PF11719.3 ESS55588.1 - 5.4 5.9 12.4 7.7 5.4 8.6 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein SDA1 PF05285.7 ESS55588.1 - 6 6.0 21.8 8.1 5.6 15.1 1.1 1 0 0 1 1 1 0 SDA1 Nucleo_P87 PF07267.6 ESS55588.1 - 9.8 4.7 11.1 12 4.4 4.5 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 VP_N-CPKC PF11475.3 ESS55589.1 - 0.94 9.0 0.1 0.94 9.0 0.0 2.5 3 0 0 3 3 3 0 Virion protein N terminal domain BNR_3 PF13859.1 ESS55590.1 - 6e-127 422.9 5.8 9.5e-127 422.3 4.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55590.1 - 5.2e-16 59.2 0.2 5.2e-16 59.2 0.1 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55590.1 - 8.4e-07 28.7 12.7 8.4e-07 28.7 8.8 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS55590.1 - 0.0021 17.3 0.1 0.0046 16.2 0.1 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Molybdop_Fe4S4 PF04879.11 ESS55592.1 - 0.29 10.9 1.8 0.65 9.8 0.2 2.1 1 1 1 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain MCLC PF05934.6 ESS55595.1 - 2.3 6.3 5.8 3.1 5.9 4.0 1.3 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Phage_integrase PF00589.17 ESS55597.1 - 0.00088 18.9 0.2 0.0015 18.2 0.1 1.6 1 1 0 1 1 1 1 Phage integrase family DDE_Tnp_1 PF01609.16 ESS55598.1 - 0.022 14.3 1.4 0.026 14.0 1.0 1.1 1 0 0 1 1 1 0 Transposase DDE domain Erythro-docking PF09277.6 ESS55598.1 - 0.043 13.4 0.2 0.095 12.4 0.1 1.6 1 0 0 1 1 1 0 Erythronolide synthase, docking Biotin_carb_C PF02785.14 ESS55598.1 - 0.091 12.7 0.2 0.67 9.9 0.1 1.9 1 1 0 2 2 2 0 Biotin carboxylase C-terminal domain Mucin PF01456.12 ESS55601.1 - 1.2e-27 96.3 28.0 1.4e-27 96.2 19.4 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein TraP PF07296.6 ESS55601.1 - 0.12 11.3 0.3 0.13 11.2 0.2 1.1 1 0 0 1 1 1 0 TraP protein DUF3484 PF11983.3 ESS55601.1 - 0.59 10.9 5.3 0.96 10.3 3.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3484) DUF4658 PF15555.1 ESS55601.1 - 7.9 6.3 6.3 1.8 8.4 0.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4658) MSA-2c PF12238.3 ESS55601.1 - 8.2 6.0 7.2 10 5.7 5.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c MGC-24 PF05283.6 ESS55601.1 - 8.8 6.0 16.0 8.8 6.0 11.1 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) DUF2360 PF10152.4 ESS55601.1 - 9.6 6.4 7.5 11 6.2 5.2 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TPK_B1_binding PF04265.9 ESS55604.1 - 0.15 11.7 0.0 0.46 10.2 0.0 1.8 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain BNR_3 PF13859.1 ESS55605.1 - 3e-97 325.4 2.0 7.1e-97 324.2 1.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55605.1 - 5e-18 65.8 1.3 1.3e-17 64.4 0.9 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily LAM_C PF12544.3 ESS55606.1 - 0.13 12.2 5.5 0.17 11.9 3.8 1.3 1 0 0 1 1 1 0 Lysine-2,3-aminomutase Enkurin PF13864.1 ESS55606.1 - 2.6 8.3 12.3 4.8 7.4 8.5 1.6 1 1 0 1 1 1 0 Calmodulin-binding Peptidase_M8 PF01457.11 ESS55607.1 - 2.5e-107 359.3 10.4 2e-106 356.4 7.2 1.9 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55607.1 - 2.5e-09 36.8 11.4 2.5e-09 36.8 7.9 2.8 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS55607.1 - 0.037 13.7 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M8 PF01457.11 ESS55609.1 - 5.3e-08 31.6 3.9 2.1e-06 26.3 2.7 2.0 1 1 0 1 1 1 1 Leishmanolysin Ndc1_Nup PF09531.5 ESS55611.1 - 8.6 4.6 7.6 0.41 9.0 0.1 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup BNR_3 PF13859.1 ESS55612.1 - 4e-05 22.8 0.0 5.7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS55612.1 - 0.052 13.3 0.2 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS55613.1 - 9.8e-48 162.7 0.1 1.6e-47 162.0 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55613.1 - 1.5e-12 47.9 0.7 1.2e-11 45.1 0.0 2.4 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55613.1 - 1.8e-08 34.0 6.1 3.7e-08 33.0 4.3 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS55613.1 - 5.4e-05 22.6 0.0 0.00017 21.0 0.0 1.8 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS55613.1 - 0.013 15.2 10.7 0.12 12.2 0.3 3.2 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF2162 PF09930.4 ESS55614.1 - 0.22 10.6 2.1 0.34 10.0 1.5 1.2 1 0 0 1 1 1 0 Predicted transporter (DUF2162) BNR_3 PF13859.1 ESS55615.1 - 5.4e-65 219.4 1.0 5.4e-65 219.4 0.7 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55615.1 - 4e-11 43.4 0.0 2.3e-10 40.9 0.0 2.3 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55615.1 - 1.3e-06 28.0 8.2 1.3e-06 28.0 5.7 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS55615.1 - 3.7e-06 26.4 3.5 0.00092 18.5 0.1 2.7 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS55615.1 - 0.00052 19.4 6.0 0.2 11.6 0.3 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat Collagen PF01391.13 ESS55615.1 - 0.05 13.1 28.9 0.88 9.1 20.0 2.4 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) GspL_C PF12693.2 ESS55615.1 - 0.24 11.1 0.0 0.43 10.3 0.0 1.3 1 0 0 1 1 1 0 GspL periplasmic domain Amidase_6 PF12671.2 ESS55619.1 - 0.035 14.1 0.3 0.054 13.5 0.2 1.2 1 0 0 1 1 1 0 Putative amidase domain LMBR1 PF04791.11 ESS55619.1 - 4.2 5.8 6.4 5.1 5.5 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein BNR_3 PF13859.1 ESS55620.1 - 8.1e-93 310.8 4.3 8.1e-93 310.8 3.0 2.1 2 1 0 2 2 2 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55620.1 - 0.0092 15.2 0.1 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Alginate_exp PF13372.1 ESS55620.1 - 0.015 13.8 0.1 0.022 13.4 0.1 1.1 1 0 0 1 1 1 0 Alginate export RHSP PF07999.6 ESS55621.1 - 3.8e-178 592.5 0.0 4.8e-178 592.2 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55622.1 - 6.9e-36 123.8 0.2 8.9e-36 123.5 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Toxin_40 PF15520.1 ESS55622.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative toxin 40 BNR_3 PF13859.1 ESS55623.1 - 6.2e-128 426.2 7.8 1e-127 425.4 5.4 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55623.1 - 4.7e-10 39.1 11.8 4.7e-10 39.1 8.2 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55626.1 - 3.3e-66 223.4 0.9 6.2e-66 222.5 0.6 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55626.1 - 3.7e-12 46.7 0.0 1.7e-11 44.5 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55626.1 - 3.4e-06 26.8 7.1 9e-06 25.4 5.0 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS55626.1 - 0.00016 21.0 4.1 0.18 11.7 0.3 3.4 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.1 ESS55626.1 - 0.00036 19.9 0.5 0.0054 16.0 0.1 2.5 1 1 1 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.1 ESS55628.1 - 3.2e-65 220.2 0.5 3.2e-65 220.2 0.3 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55628.1 - 1.9e-12 47.6 0.0 8.4e-12 45.6 0.0 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55628.1 - 7.7e-06 25.6 10.0 7.7e-06 25.6 6.9 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS55628.1 - 0.00075 18.9 6.1 0.16 11.8 0.4 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat DUF1117 PF06547.7 ESS55628.1 - 0.047 13.7 0.5 0.16 12.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) Neur_chan_memb PF02932.11 ESS55629.1 - 0.1 12.4 0.4 0.11 12.3 0.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EVI2A PF05399.6 ESS55629.1 - 0.2 10.8 3.0 0.24 10.6 2.1 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF4653 PF15546.1 ESS55629.1 - 0.33 10.2 3.3 0.4 9.9 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) FNIP_N PF14636.1 ESS55629.1 - 0.56 10.6 4.5 0.93 9.9 3.1 1.4 1 1 0 1 1 1 0 Folliculin-interacting protein N-terminus Herpes_TAF50 PF03326.8 ESS55629.1 - 0.61 8.9 9.5 0.64 8.8 6.6 1.0 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Herpes_DNAp_acc PF04929.7 ESS55629.1 - 2.2 7.1 6.1 2.6 6.9 4.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor P_C PF06640.6 ESS55629.1 - 4.8 7.1 8.1 1.1 9.1 3.2 1.6 1 1 1 2 2 2 0 P protein C-terminus RVT_1 PF00078.22 ESS55630.1 - 0.055 12.8 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) IFT57 PF10498.4 ESS55631.1 - 0.0014 17.4 1.7 0.0019 17.0 1.2 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF4407 PF14362.1 ESS55631.1 - 0.027 13.4 8.3 0.035 13.0 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC144C PF14915.1 ESS55631.1 - 0.051 12.4 2.6 0.068 12.0 1.8 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region YlqD PF11068.3 ESS55631.1 - 1.4 8.9 4.6 2.1 8.3 3.2 1.3 1 0 0 1 1 1 0 YlqD protein HAUS4 PF14735.1 ESS55633.1 - 0.059 12.6 0.0 0.088 12.0 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Nop14 PF04147.7 ESS55635.1 - 0.086 10.7 28.0 0.097 10.5 19.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.5 ESS55635.1 - 0.34 10.0 37.6 0.43 9.7 26.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CytochromB561_N PF09786.4 ESS55635.1 - 0.68 8.3 7.3 0.76 8.1 5.0 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal NOA36 PF06524.7 ESS55635.1 - 2.2 7.4 14.5 2.9 7.0 10.0 1.3 1 0 0 1 1 1 0 NOA36 protein Nucleo_P87 PF07267.6 ESS55635.1 - 5.8 5.4 16.1 7.2 5.1 11.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AvrE PF11725.3 ESS55635.1 - 6.2 3.7 19.3 7.5 3.4 13.4 1.0 1 0 0 1 1 1 0 Pathogenicity factor Parvo_coat PF00740.13 ESS55635.1 - 6.3 5.6 11.4 7.3 5.4 7.9 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Ycf1 PF05758.7 ESS55635.1 - 8.2 4.0 19.8 11 3.6 13.7 1.1 1 0 0 1 1 1 0 Ycf1 CDC45 PF02724.9 ESS55635.1 - 9.4 4.1 22.1 13 3.7 15.3 1.1 1 0 0 1 1 1 0 CDC45-like protein BNR_3 PF13859.1 ESS55637.1 - 1.2e-07 31.1 0.0 3.1e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 BNR repeat-like domain Dynein_heavy PF03028.10 ESS55637.1 - 0.045 11.7 0.0 0.057 11.4 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor DUF3005 PF11448.3 ESS55637.1 - 0.089 12.4 0.1 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) PH PF00169.24 ESS55639.1 - 0.031 14.4 0.2 0.68 10.1 0.0 2.8 2 1 0 2 2 2 0 PH domain Arv1 PF04161.8 ESS55640.1 - 1.9e-21 76.9 0.4 2.8e-21 76.3 0.3 1.2 1 0 0 1 1 1 1 Arv1-like family DNA_pol_viral_C PF00336.13 ESS55641.1 - 0.011 14.9 0.0 0.036 13.3 0.0 1.8 1 1 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Phage_integrase PF00589.17 ESS55642.1 - 0.0019 17.8 0.6 0.0042 16.7 0.1 1.9 2 1 0 2 2 2 1 Phage integrase family DUF4407 PF14362.1 ESS55643.1 - 0.064 12.2 5.4 0.091 11.7 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IFT57 PF10498.4 ESS55643.1 - 0.12 11.0 2.0 0.18 10.5 1.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 MAD PF05557.8 ESS55643.1 - 0.15 10.1 3.2 0.19 9.7 2.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Spc7 PF08317.6 ESS55643.1 - 0.17 10.5 1.1 0.26 9.9 0.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein BNR_3 PF13859.1 ESS55645.1 - 1.8e-46 158.6 1.8 2.1e-46 158.4 1.2 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55645.1 - 0.0009 18.6 0.1 0.0012 18.1 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55647.1 - 5.3e-27 94.6 0.0 1.2e-26 93.5 0.0 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55647.1 - 9.2e-15 55.2 0.1 9.2e-15 55.2 0.1 2.4 2 2 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55647.1 - 2.4e-10 40.1 9.9 5.2e-10 39.0 6.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55648.1 - 1.8e-118 395.1 4.6 4.8e-118 393.7 3.2 1.8 1 1 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55648.1 - 2e-17 63.8 2.4 3e-17 63.3 0.6 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55648.1 - 1.8e-11 43.6 11.0 1.8e-11 43.6 7.6 2.4 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RVT_3 PF13456.1 ESS55651.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like Glycos_transf_2 PF00535.21 ESS55652.1 - 9.1e-05 22.2 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 HAUS4 PF14735.1 ESS55652.1 - 0.023 14.0 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 DUF3296 PF11726.3 ESS55652.1 - 0.071 12.6 0.0 0.099 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3296) BNR_3 PF13859.1 ESS55654.1 - 3.3e-128 427.1 3.9 6.9e-128 426.0 2.7 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55654.1 - 4.7e-15 56.1 0.9 1.2e-14 54.8 0.2 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS55654.1 - 0.00088 18.6 0.2 0.005 16.1 0.0 2.3 2 1 0 2 2 2 1 BNR repeat-like domain RHSP PF07999.6 ESS55656.1 - 2.9e-89 299.6 0.2 4.6e-89 299.0 0.1 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Laminin_G_3 PF13385.1 ESS55656.1 - 4e-13 49.8 0.1 9.6e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55657.1 - 8.1e-42 143.3 0.3 9.6e-42 143.1 0.2 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55657.1 - 4.7e-06 26.0 0.9 9.9e-06 25.0 0.6 1.7 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS55657.1 - 0.0078 15.8 1.9 0.38 10.7 0.2 3.4 3 0 0 3 3 3 1 BNR/Asp-box repeat Laminin_G_3 PF13385.1 ESS55659.1 - 4.5e-07 30.2 0.1 6.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF778 PF05608.7 ESS55659.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF778) BNR_3 PF13859.1 ESS55660.1 - 1.1e-24 87.1 0.0 3e-24 85.6 0.0 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55660.1 - 1.5e-08 34.9 0.0 3.3e-07 30.6 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4610 PF15384.1 ESS55661.1 - 0.059 12.9 0.2 0.059 12.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4610) BNR_3 PF13859.1 ESS55663.1 - 1.1e-117 392.5 6.4 1.3e-117 392.2 3.8 1.5 2 0 0 2 2 2 1 BNR repeat-like domain SSI PF00720.12 ESS55663.1 - 0.069 13.0 0.1 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 Subtilisin inhibitor-like ATP-synt_D PF01813.12 ESS55665.1 - 0.091 12.3 0.3 0.18 11.3 0.2 1.4 1 0 0 1 1 1 0 ATP synthase subunit D IFT57 PF10498.4 ESS55665.1 - 0.13 10.9 2.0 0.2 10.3 1.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.6 ESS55665.1 - 0.16 10.6 0.5 0.27 9.8 0.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESS55665.1 - 0.25 10.2 6.2 0.38 9.6 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.3 ESS55665.1 - 1.7 8.7 4.4 2.9 7.9 3.0 1.4 1 0 0 1 1 1 0 YlqD protein RHSP PF07999.6 ESS55667.1 - 9.7e-35 119.9 0.0 1.1e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein PPV_E2_N PF00508.12 ESS55667.1 - 0.047 12.8 0.0 0.07 12.3 0.0 1.2 1 0 0 1 1 1 0 E2 (early) protein, N terminal BNR_3 PF13859.1 ESS55669.1 - 8.7e-62 208.9 2.3 4.2e-61 206.6 0.3 2.4 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55669.1 - 7.8e-16 58.7 0.2 7.8e-16 58.7 0.1 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55669.1 - 8e-11 41.6 11.1 1.8e-10 40.4 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55670.1 - 8.8e-55 185.9 1.4 1.1e-54 185.6 1.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Lysozyme_like PF13702.1 ESS55670.1 - 0.046 13.2 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Lysozyme-like Vac7 PF12751.2 ESS55670.1 - 0.52 9.1 2.0 0.44 9.3 0.5 1.4 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 DUF4607 PF15380.1 ESS55671.1 - 0.061 12.7 7.9 0.14 11.6 5.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4607) Tox-SHH PF15652.1 ESS55673.1 - 1.2 9.7 4.2 8.8 6.9 0.3 2.4 2 1 0 2 2 2 0 HNH/Endo VII superfamily toxin with a SHH signature PhaC_N PF07167.8 ESS55674.1 - 0.11 11.9 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus BNR_3 PF13859.1 ESS55678.1 - 5.7e-127 423.0 5.0 1.2e-126 422.0 3.5 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55678.1 - 3.2e-18 66.4 0.3 1.1e-17 64.7 0.2 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55678.1 - 2.5e-10 40.0 12.2 2.5e-10 40.0 8.5 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS55679.1 - 2.3e-95 319.7 0.0 2.8e-95 319.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein LCE PF14672.1 ESS55682.1 - 0.013 15.9 2.0 0.013 15.9 1.4 2.2 2 0 0 2 2 2 0 Late cornified envelope BNR_3 PF13859.1 ESS55684.1 - 1.1e-58 198.7 5.3 1.4e-58 198.3 3.7 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS55684.1 - 0.27 11.0 1.4 0.69 9.6 1.0 1.7 1 1 0 1 1 1 0 Mucin-like glycoprotein RHSP PF07999.6 ESS55685.1 - 3.1e-77 260.0 1.0 4.6e-77 259.4 0.7 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55685.1 - 0.016 15.3 0.5 8.8 6.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain BNR_3 PF13859.1 ESS55689.1 - 5.1e-34 117.7 0.1 8.3e-34 117.0 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55689.1 - 1.4e-13 51.3 2.2 2.4e-13 50.6 0.7 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55689.1 - 0.0014 18.4 3.2 0.0028 17.4 2.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS55689.1 - 0.86 9.6 0.0 0.86 9.6 0.0 4.0 5 0 0 5 5 5 0 BNR/Asp-box repeat Tankyrase_bdg_C PF15327.1 ESS55690.1 - 0.24 11.5 5.0 7.7 6.6 2.1 2.8 2 1 0 2 2 2 0 Tankyrase binding protein C terminal domain Med25_NR-box PF11244.3 ESS55691.1 - 1 9.8 4.9 0.73 10.3 2.2 1.6 2 0 0 2 2 2 0 Mediator complex subunit 25 C-terminal NR box-containing DGF-1_4 PF11024.3 ESS55692.1 - 4.4e-10 39.7 2.5 1.3e-09 38.3 1.8 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS55693.1 - 3e-25 88.7 0.0 3.8e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55699.1 - 1.6e-132 441.2 6.3 1.6e-132 441.2 4.4 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55699.1 - 5.4e-14 52.7 0.4 1.3e-13 51.5 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55699.1 - 8.2e-12 44.7 6.7 2.1e-11 43.4 4.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55703.1 - 4.3e-130 433.3 3.0 4.3e-130 433.3 2.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55703.1 - 9.5e-17 61.6 2.9 2.7e-16 60.2 2.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55703.1 - 8e-07 28.8 13.5 2.4e-06 27.3 9.4 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Glyco_hydro_32N PF00251.15 ESS55703.1 - 0.097 12.0 0.8 5.9 6.1 0.1 2.6 2 1 1 3 3 3 0 Glycosyl hydrolases family 32 N-terminal domain RVT_1 PF00078.22 ESS55704.1 - 4.3e-20 72.0 0.1 5.4e-20 71.6 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR_3 PF13859.1 ESS55705.1 - 2.7e-66 223.7 1.9 3.1e-66 223.5 0.4 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55705.1 - 5.3e-17 62.4 1.2 1.1e-16 61.4 0.8 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55705.1 - 1.7e-06 27.7 9.9 4e-06 26.5 6.9 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS55708.1 - 2.2e-120 402.2 0.4 2.9e-120 401.8 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55709.1 - 1.7e-130 434.6 7.4 2.7e-130 433.9 5.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55709.1 - 3.2e-17 63.2 0.2 6.6e-17 62.1 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55709.1 - 6.1e-10 38.7 15.7 7.5e-10 38.5 8.4 2.7 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55711.1 - 4.4e-131 436.5 7.9 4.4e-131 436.5 5.5 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55711.1 - 1.5e-18 67.5 0.7 1.5e-18 67.5 0.5 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55711.1 - 3.7e-05 23.5 6.7 3.7e-05 23.5 4.6 2.6 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Cytomega_UL20A PF05984.7 ESS55711.1 - 0.63 10.2 5.0 9.3 6.5 1.8 3.3 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein Gmx_para_CXXCG PF09535.5 ESS55712.1 - 0.015 14.2 2.1 1.5 7.7 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (Gmx_para_CXXCG) SNN_cytoplasm PF09051.5 ESS55712.1 - 0.17 11.6 3.1 11 5.8 0.2 2.4 2 0 0 2 2 2 0 Stannin cytoplasmic Kunitz_legume PF00197.13 ESS55712.1 - 0.54 9.7 10.3 1.2 8.6 1.0 2.2 1 1 1 2 2 2 0 Trypsin and protease inhibitor RVT_connect PF06815.8 ESS55712.1 - 0.56 10.1 7.6 1.9 8.4 2.2 2.4 1 1 1 2 2 2 0 Reverse transcriptase connection domain DUF1642 PF07852.6 ESS55712.1 - 1.1 9.6 5.9 3.9 7.8 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1642) BNR_3 PF13859.1 ESS55715.1 - 1.6e-36 125.9 0.3 5e-36 124.3 0.2 1.8 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55715.1 - 2.4e-18 66.8 0.4 2.4e-18 66.8 0.3 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55715.1 - 1.2e-08 34.6 17.1 3e-08 33.3 11.8 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PSCyt3 PF07627.6 ESS55716.1 - 0.098 12.5 1.4 0.13 12.1 0.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) DUF3720 PF12517.3 ESS55719.1 - 4e-19 69.1 5.2 4e-19 69.1 3.6 4.1 2 2 1 4 4 4 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS55720.1 - 5.8e-22 78.1 0.2 7.4e-22 77.7 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain RVT_1 PF00078.22 ESS55722.1 - 1.2e-26 93.4 0.0 1.6e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS55722.1 - 0.05 13.4 0.2 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 EBP50, C-terminal RNase_H PF00075.19 ESS55723.1 - 3e-05 24.3 0.0 5.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 RNase H AKAP95 PF04988.7 ESS55723.1 - 0.16 11.7 0.5 15 5.3 0.0 2.2 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_2 PF13465.1 ESS55723.1 - 1.1 9.7 5.0 9.7 6.6 0.8 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS55723.1 - 6.7 7.2 8.6 5.8 7.4 1.4 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger DUF3720 PF12517.3 ESS55724.1 - 8.9e-23 80.8 10.9 8.9e-23 80.8 7.6 4.3 1 1 2 4 4 4 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS55729.1 - 1.1e-23 83.7 0.0 1.4e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS55734.1 - 7.1e-11 41.7 0.0 1.2e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain DUF1272 PF06906.6 ESS55735.1 - 0.31 10.9 7.9 0.068 13.0 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) BNR_3 PF13859.1 ESS55737.1 - 1e-75 254.7 2.9 1e-75 254.7 2.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55737.1 - 2.3e-18 66.9 0.1 5e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS55738.1 - 2.3e-135 450.6 3.1 2.3e-135 450.6 2.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55738.1 - 1.5e-18 67.4 0.6 1.5e-18 67.4 0.4 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55738.1 - 1.8e-10 40.4 6.4 5.6e-10 38.9 4.4 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal FdtA PF05523.6 ESS55739.1 - 0.14 11.7 0.4 0.27 10.7 0.3 1.4 1 0 0 1 1 1 0 WxcM-like, C-terminal P12 PF12669.2 ESS55739.1 - 2.6 8.3 6.8 0.5 10.6 2.1 1.8 2 0 0 2 2 2 0 Virus attachment protein p12 family FAM163 PF15069.1 ESS55739.1 - 8.5 6.9 8.7 2.2 8.8 2.7 2.3 1 1 1 2 2 2 0 FAM163 family RHSP PF07999.6 ESS55741.1 - 1.6e-83 280.7 0.0 2.3e-83 280.2 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Alpha_GJ PF03229.8 ESS55744.1 - 0.88 9.9 7.4 0.15 12.4 1.7 2.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J Macoilin PF09726.4 ESS55744.1 - 1.4 7.0 9.7 1.6 6.8 6.7 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF3676 PF12429.3 ESS55746.1 - 3.8e-105 350.5 51.2 5.9e-105 349.9 35.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS55746.1 - 2.7e-79 266.4 0.0 2.7e-79 266.4 0.0 2.4 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55746.1 - 5.3e-10 38.9 6.2 1.2e-09 37.9 4.3 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55747.1 - 1.6e-130 434.7 3.0 1.6e-130 434.7 2.1 2.7 3 1 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55747.1 - 6.9e-15 55.6 0.1 2.3e-14 53.8 0.0 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55747.1 - 4.3e-08 32.8 9.0 9.1e-08 31.8 6.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS55750.1 - 5.2e-107 358.1 0.0 7.4e-107 357.6 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein MAP7 PF05672.6 ESS55750.1 - 0.0045 16.3 15.0 0.0083 15.5 10.4 1.3 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family AAA_22 PF13401.1 ESS55750.1 - 0.017 15.2 0.5 10 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain zf-C2H2_jaz PF12171.3 ESS55753.1 - 0.063 13.4 4.0 3.1 8.0 1.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 ESS55753.1 - 0.068 13.4 7.1 0.4 11.0 1.5 2.7 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS55753.1 - 0.21 12.0 10.7 1.9 9.0 2.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS55753.1 - 0.27 11.6 16.4 1 9.8 3.3 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESS55753.1 - 0.45 10.4 5.2 4 7.4 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESS55753.1 - 1.2 9.3 8.2 3.5 7.8 5.7 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Laminin_G_3 PF13385.1 ESS55757.1 - 5.7e-12 46.1 0.2 5.7e-12 46.1 0.1 1.9 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55757.1 - 4.4e-10 39.2 5.4 1.2e-09 37.9 3.7 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2_4 PF13894.1 ESS55759.1 - 0.15 12.4 0.4 0.15 12.4 0.3 3.4 4 0 0 4 4 4 0 C2H2-type zinc finger CAP_N PF01213.14 ESS55759.1 - 3.6 6.7 10.9 14 4.8 0.1 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal RHSP PF07999.6 ESS55760.1 - 1.2e-44 152.6 0.0 1.7e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55761.1 - 5.1e-37 127.6 1.1 5.9e-37 127.3 0.7 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS55761.1 - 3.7e-05 22.9 4.2 0.046 13.5 0.2 2.7 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.1 ESS55761.1 - 0.00035 19.9 0.1 0.00085 18.6 0.1 1.6 1 1 0 1 1 1 1 BNR repeat-like domain DUF4185 PF13810.1 ESS55761.1 - 0.038 12.8 0.2 0.38 9.5 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4185) Peptidase_M8 PF01457.11 ESS55762.1 - 1.1e-32 113.0 0.1 1.4e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Sec1 PF00995.18 ESS55763.1 - 4.5e-106 355.7 0.0 5.3e-106 355.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Allene_ox_cyc PF06351.6 ESS55763.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Allene oxide cyclase Abhydrolase_9 PF10081.4 ESS55764.1 - 0.045 12.4 0.2 0.085 11.5 0.2 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family ATP-synt_A PF00119.15 ESS55765.1 - 0.18 11.3 4.3 0.19 11.1 2.9 1.1 1 0 0 1 1 1 0 ATP synthase A chain DUF4131 PF13567.1 ESS55765.1 - 0.75 9.1 7.0 1.1 8.6 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) BNR_3 PF13859.1 ESS55766.1 - 1.4e-129 431.6 3.5 2.9e-129 430.5 2.5 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55766.1 - 1.5e-17 64.2 1.5 4.6e-17 62.6 1.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55766.1 - 2.4e-11 43.2 11.1 6e-11 41.9 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Beta_helix PF13229.1 ESS55774.1 - 0.064 13.0 2.0 0.64 9.7 0.6 2.8 2 0 0 2 2 2 0 Right handed beta helix region DUF3568 PF12092.3 ESS55774.1 - 1.8 8.2 7.9 6.4 6.4 0.3 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3568) Glycos_transf_2 PF00535.21 ESS55778.1 - 0.0023 17.6 0.0 0.0043 16.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS55778.1 - 0.033 13.2 0.0 2.3 7.2 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Tr-sialidase_C PF11052.3 ESS55779.1 - 7.5e-08 32.1 5.4 1.7e-07 30.9 3.8 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3270 PF11674.3 ESS55780.1 - 1 9.3 6.9 2.2 8.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) BNR_3 PF13859.1 ESS55781.1 - 6.1e-23 81.3 0.0 1.3e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55781.1 - 4.7e-21 75.6 0.6 1.5e-20 74.0 0.4 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55781.1 - 6.7e-11 41.8 12.9 1.8e-10 40.4 8.9 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal IncA PF04156.9 ESS55786.1 - 0.01 15.4 2.9 0.013 15.1 2.0 1.1 1 0 0 1 1 1 0 IncA protein DUF4407 PF14362.1 ESS55786.1 - 0.033 13.1 4.1 0.04 12.8 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MAD PF05557.8 ESS55786.1 - 0.073 11.1 6.2 0.093 10.8 4.3 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein V_ATPase_I PF01496.14 ESS55786.1 - 0.089 10.6 0.8 0.11 10.2 0.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IFT57 PF10498.4 ESS55786.1 - 0.17 10.5 4.2 0.23 10.1 2.9 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESS55786.1 - 0.39 9.6 4.3 0.51 9.2 3.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 MLIP PF15274.1 ESS55787.1 - 0.11 11.9 0.1 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Muscular LMNA-interacting protein BNR_3 PF13859.1 ESS55791.1 - 9.8e-131 435.4 5.4 1.9e-130 434.4 3.7 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55791.1 - 3.7e-15 56.5 0.1 3.7e-15 56.5 0.1 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55791.1 - 1.6e-10 40.6 8.7 3.7e-10 39.5 6.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Exo_endo_phos_2 PF14529.1 ESS55793.1 - 2.8e-16 59.2 0.0 5.5e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS55793.1 - 6.4e-13 49.2 0.0 1.1e-12 48.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sipho_Gp157 PF05565.6 ESS55793.1 - 0.092 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 RVT_1 PF00078.22 ESS55794.1 - 1.6e-32 112.5 0.0 4e-32 111.3 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Carmo_coat_C PF08462.5 ESS55794.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Carmovirus coat protein RVT_1 PF00078.22 ESS55796.1 - 3.1e-05 23.4 0.0 4e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR_3 PF13859.1 ESS55797.1 - 1.2e-117 392.3 4.4 3.4e-117 390.9 3.1 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55797.1 - 4.2e-15 56.3 0.2 1.3e-14 54.7 0.1 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55797.1 - 3.7e-09 36.2 10.8 8.1e-09 35.1 7.5 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Arv1 PF04161.8 ESS55805.1 - 3.9e-24 85.7 0.7 6.3e-24 85.0 0.5 1.3 1 0 0 1 1 1 1 Arv1-like family FAM70 PF14967.1 ESS55805.1 - 0.0076 15.4 0.2 0.011 14.9 0.1 1.4 1 0 0 1 1 1 1 FAM70 protein DNA_pol_viral_C PF00336.13 ESS55808.1 - 0.0044 16.3 0.3 0.034 13.4 0.0 2.2 2 0 0 2 2 2 1 DNA polymerase (viral) C-terminal domain Phage_integrase PF00589.17 ESS55809.1 - 0.0096 15.5 0.1 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 Phage integrase family zf-C2H2 PF00096.21 ESS55811.1 - 3.5 8.1 7.0 9 6.8 0.3 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type DGF-1_5 PF11038.3 ESS55814.1 - 1.1e-162 539.7 18.7 1.1e-162 539.7 13.0 2.7 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS55814.1 - 1.9e-38 130.6 17.7 1.9e-38 130.6 12.3 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS55814.1 - 2e-37 126.9 2.0 2e-37 126.9 1.4 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus PRA1 PF03208.14 ESS55816.1 - 0.012 14.9 2.9 0.012 14.9 2.0 1.8 2 0 0 2 2 2 0 PRA1 family protein Peptidase_M8 PF01457.11 ESS55817.1 - 1.4e-42 145.8 11.8 2.1e-41 141.8 8.2 2.1 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55817.1 - 4e-11 42.5 2.3 7.1e-11 41.7 1.6 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2_4 PF13894.1 ESS55818.1 - 0.13 12.6 0.3 0.13 12.6 0.2 3.1 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS55818.1 - 0.24 11.8 3.8 0.33 11.3 0.4 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type P12 PF12669.2 ESS55820.1 - 0.35 11.0 4.5 0.63 10.2 3.2 1.5 1 0 0 1 1 1 0 Virus attachment protein p12 family ASRT PF07100.6 ESS55821.1 - 0.031 14.0 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer Mucin PF01456.12 ESS55821.1 - 0.12 12.1 0.6 0.15 11.8 0.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS55822.1 - 2e-130 434.4 8.1 2e-130 434.4 5.6 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55822.1 - 2.8e-17 63.3 1.1 5e-17 62.5 0.1 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55822.1 - 9.6e-10 38.1 10.8 2.6e-09 36.7 7.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal oligo_HPY PF08352.7 ESS55824.1 - 1.4 9.3 4.3 12 6.3 0.4 2.6 2 1 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region Tr-sialidase_C PF11052.3 ESS55825.1 - 1.8e-05 24.4 1.1 4.2e-05 23.3 0.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal X PF00739.14 ESS55826.1 - 0.13 12.1 3.2 0.22 11.3 2.2 1.4 1 0 0 1 1 1 0 Trans-activation protein X DUF2826 PF11442.3 ESS55828.1 - 1.4e-89 297.9 8.0 1.4e-89 297.9 5.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2826) BNR_3 PF13859.1 ESS55829.1 - 2.3e-31 109.0 0.2 6.3e-31 107.5 0.1 1.8 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55829.1 - 2.7e-16 60.1 0.8 6.2e-16 59.0 0.6 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55829.1 - 2.3e-05 24.1 14.8 0.0001 22.0 10.3 2.1 1 1 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF1345 PF07077.6 ESS55832.1 - 0.1 12.1 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) PPK2 PF03976.9 ESS55833.1 - 0.039 13.2 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) CPSF_A PF03178.10 ESS55834.1 - 1.8e-46 158.7 0.0 7.2e-46 156.7 0.0 1.8 2 0 0 2 2 2 1 CPSF A subunit region BNR_3 PF13859.1 ESS55835.1 - 2.8e-127 424.0 7.3 3.4e-127 423.8 3.3 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55835.1 - 1.2e-10 41.0 11.1 2.7e-10 39.9 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal NT-C2 PF10358.4 ESS55835.1 - 0.31 10.5 2.1 6.4 6.2 0.1 3.1 4 0 0 4 4 4 0 N-terminal C2 in EEIG1 and EHBP1 proteins Neisseria_TspB PF05616.8 ESS55835.1 - 5 5.3 8.9 8.4 4.6 6.2 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF2625 PF10946.3 ESS55836.1 - 0.061 12.2 0.0 0.087 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF2625 Phage_integrase PF00589.17 ESS55838.1 - 0.00039 20.1 0.1 0.0007 19.3 0.0 1.6 1 0 0 1 1 1 1 Phage integrase family Y2_Tnp PF04986.8 ESS55838.1 - 0.04 13.6 0.1 0.076 12.7 0.1 1.6 1 1 0 1 1 1 0 Putative transposase RHSP PF07999.6 ESS55839.1 - 8.5e-64 215.7 0.1 1.3e-63 215.1 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Laminin_G_3 PF13385.1 ESS55843.1 - 3.2e-18 66.4 1.5 3.2e-18 66.4 1.0 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55843.1 - 5.5e-12 45.3 10.7 9.9e-12 44.5 6.9 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF1664 PF07889.7 ESS55847.1 - 0.0018 18.1 0.9 0.0034 17.1 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Phycobilisome PF00502.14 ESS55847.1 - 0.017 14.8 0.2 1.9 8.2 0.1 2.2 1 1 1 2 2 2 0 Phycobilisome protein Fib_alpha PF08702.5 ESS55847.1 - 0.027 14.5 2.4 0.032 14.3 1.2 1.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Reo_sigmaC PF04582.7 ESS55847.1 - 0.083 12.0 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Bacillus_HBL PF05791.6 ESS55847.1 - 0.099 12.0 0.7 1.1 8.6 0.2 2.0 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ADIP PF11559.3 ESS55847.1 - 0.95 9.3 9.9 0.19 11.6 4.3 1.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.4 ESS55847.1 - 2 8.2 8.2 2.6 7.9 3.8 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lge1 PF11488.3 ESS55847.1 - 2.5 8.3 5.9 2.1 8.5 2.9 1.9 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 IncA PF04156.9 ESS55847.1 - 6.6 6.2 11.4 4.6 6.7 5.9 1.8 1 1 1 2 2 2 0 IncA protein Reo_sigmaC PF04582.7 ESS55848.1 - 0.33 10.0 20.5 0.2 10.7 1.5 3.6 2 1 2 4 4 4 0 Reovirus sigma C capsid protein DUF4201 PF13870.1 ESS55848.1 - 7 6.0 50.0 0.56 9.6 2.5 6.1 2 2 4 6 6 6 0 Domain of unknown function (DUF4201) Mt_ATP-synt_B PF05405.9 ESS55849.1 - 1.7 8.0 3.8 7.2 6.0 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) adh_short PF00106.20 ESS55850.1 - 1.5e-23 83.5 1.6 8.7e-23 81.0 1.1 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS55850.1 - 3.2e-09 36.7 0.2 6.6e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESS55850.1 - 1.5e-06 28.2 0.0 3.2e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ESS55850.1 - 7.2e-06 25.6 0.2 1.2e-05 24.8 0.2 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESS55850.1 - 0.015 15.3 0.1 0.044 13.7 0.0 1.7 1 1 0 1 1 1 0 NADH(P)-binding RNase_H PF00075.19 ESS55851.1 - 2.3e-13 50.5 0.0 3.6e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS55851.1 - 0.17 11.3 1.8 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 DAN domain zf-H2C2_2 PF13465.1 ESS55851.1 - 0.32 11.3 6.4 1.4 9.3 1.5 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESS55851.1 - 2.3 8.7 14.1 1.6 9.2 1.6 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS55851.1 - 7.1 7.2 12.6 9.2 6.8 1.5 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger BNR_3 PF13859.1 ESS55855.1 - 9.5e-29 100.4 0.3 9.5e-29 100.4 0.2 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55855.1 - 1.8e-13 51.0 2.0 3.4e-13 50.1 1.4 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_M8 PF01457.11 ESS55856.1 - 6.2e-35 120.5 10.5 2.1e-33 115.4 7.3 2.1 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS55856.1 - 2.9e-12 46.2 8.7 2.9e-12 46.2 6.0 2.4 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55858.1 - 4.4e-106 354.4 2.7 4.4e-106 354.4 1.9 1.4 2 0 0 2 2 2 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55858.1 - 0.0027 17.0 0.1 0.0039 16.5 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain DUF2208 PF09973.4 ESS55859.1 - 4.1 6.5 8.0 4.4 6.4 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Mucin PF01456.12 ESS55860.1 - 4.4e-32 110.8 51.6 8.5e-22 77.4 16.8 2.5 1 1 1 2 2 2 2 Mucin-like glycoprotein BNR_3 PF13859.1 ESS55863.1 - 4.9e-64 216.3 0.2 4.9e-64 216.3 0.1 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55863.1 - 2.9e-16 60.0 0.8 7e-16 58.8 0.6 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55863.1 - 3.9e-11 42.6 11.7 8.9e-11 41.4 8.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MukB PF04310.7 ESS55866.1 - 0.087 12.1 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 MukB N-terminal RHSP PF07999.6 ESS55868.1 - 1.9e-42 145.3 0.0 3.8e-42 144.4 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS55870.1 - 5.2e-15 55.2 0.0 7.5e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF3693 PF12472.3 ESS55870.1 - 0.18 11.4 1.2 0.43 10.2 0.8 1.6 1 0 0 1 1 1 0 Phage related protein BNR_3 PF13859.1 ESS55871.1 - 6.6e-32 110.8 0.9 8.6e-32 110.4 0.6 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS55871.1 - 0.017 14.8 0.4 0.07 12.9 0.3 2.1 1 0 0 1 1 1 0 BNR/Asp-box repeat Mucin PF01456.12 ESS55871.1 - 2.7 7.7 5.9 8.3 6.1 4.1 1.9 1 1 0 1 1 1 0 Mucin-like glycoprotein RHSP PF07999.6 ESS55872.1 - 3.3e-34 118.2 0.0 5.3e-34 117.5 0.0 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein Toxin_25 PF08095.6 ESS55872.1 - 0.26 11.0 2.1 4.2 7.2 0.1 2.7 2 0 0 2 2 2 0 Hefutoxin family Gram_pos_anchor PF00746.16 ESS55873.1 - 5.4 6.9 5.9 1.6 8.6 1.2 2.4 2 1 0 2 2 2 0 Gram positive anchor BNR_3 PF13859.1 ESS55874.1 - 1.3e-36 126.2 0.3 2.1e-36 125.5 0.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55874.1 - 4.8e-11 43.1 0.2 1.4e-10 41.6 0.0 1.9 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55874.1 - 1.5e-05 24.7 8.2 3.6e-05 23.5 5.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS55874.1 - 0.4 10.7 2.6 0.82 9.7 0.2 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat Mucin PF01456.12 ESS55879.1 - 5.6e-39 133.1 20.5 4.3e-38 130.3 15.1 1.7 2 0 0 2 2 2 1 Mucin-like glycoprotein BNR_3 PF13859.1 ESS55880.1 - 4.7e-134 446.3 3.7 7.2e-134 445.7 2.6 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55880.1 - 4e-07 29.6 0.0 5.8e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55883.1 - 3.6e-15 56.5 0.1 9.8e-15 55.1 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55883.1 - 4.2e-12 45.6 12.1 4.2e-12 45.6 8.4 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS55886.1 - 5e-37 126.8 66.4 8.9e-37 126.0 46.0 1.4 1 1 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS55886.1 - 0.014 15.9 9.1 0.016 15.7 6.3 1.1 1 0 0 1 1 1 0 FAM163 family DUF1675 PF07897.6 ESS55886.1 - 0.16 11.7 7.9 0.2 11.4 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DUF2360 PF10152.4 ESS55886.1 - 0.23 11.7 4.3 0.27 11.4 3.0 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) MCPVI PF02993.9 ESS55886.1 - 0.46 10.6 9.6 0.52 10.4 6.7 1.0 1 0 0 1 1 1 0 Minor capsid protein VI Cyto_heme_lyase PF01265.12 ESS55886.1 - 1.4 8.4 7.6 1.7 8.1 5.2 1.0 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase LAT PF15234.1 ESS55886.1 - 4 6.8 8.8 6 6.2 6.1 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells TFIIA PF03153.8 ESS55886.1 - 9.7 5.9 8.7 11 5.7 6.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ustilago_mating PF05722.7 ESS55887.1 - 1.1 8.4 4.3 1.2 8.3 3.0 1.1 1 0 0 1 1 1 0 Ustilago B locus mating-type protein BNR_3 PF13859.1 ESS55891.1 - 7.8e-26 90.8 0.1 9.9e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Glyoxalase PF00903.20 ESS55891.1 - 0.082 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Tr-sialidase_C PF11052.3 ESS55892.1 - 3e-07 30.1 4.1 6.7e-07 29.0 2.9 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Thyroglobulin_1 PF00086.13 ESS55893.1 - 0.0042 16.4 0.5 0.0087 15.3 0.3 1.6 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Gag_p17 PF00540.13 ESS55893.1 - 0.12 12.1 1.0 0.19 11.4 0.7 1.3 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) BNR_3 PF13859.1 ESS55894.1 - 2.9e-119 397.7 6.8 6.1e-119 396.6 4.7 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55894.1 - 5e-16 59.3 0.3 1.5e-15 57.7 0.2 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55894.1 - 9.5e-09 34.9 14.7 2.1e-08 33.8 10.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS55895.1 - 1.1e-40 138.7 53.1 1.3e-40 138.4 36.8 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS55895.1 - 0.0022 18.6 7.8 0.0027 18.2 5.4 1.1 1 0 0 1 1 1 1 FAM163 family Shisa PF13908.1 ESS55895.1 - 0.071 13.2 15.7 0.12 12.5 10.8 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator UPF0114 PF03350.11 ESS55895.1 - 0.092 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 Otopetrin PF03189.8 ESS55895.1 - 0.14 11.1 0.6 0.15 11.0 0.4 1.0 1 0 0 1 1 1 0 Otopetrin DUF1675 PF07897.6 ESS55895.1 - 0.27 11.0 9.2 0.35 10.7 6.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Presenilin PF01080.12 ESS55895.1 - 1.6 7.4 5.2 1.9 7.2 3.6 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.3 ESS55895.1 - 2.5 6.5 4.3 2.9 6.3 3.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MCPVI PF02993.9 ESS55895.1 - 3.6 7.6 11.0 4.2 7.4 7.6 1.0 1 0 0 1 1 1 0 Minor capsid protein VI DUF2360 PF10152.4 ESS55895.1 - 6.3 7.0 10.3 8.3 6.6 7.2 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) RHSP PF07999.6 ESS55897.1 - 1e-113 380.2 0.9 2.2e-113 379.1 0.1 1.9 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS55897.1 - 0.002 18.2 0.0 3.1 7.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF605 PF04652.11 ESS55898.1 - 2.2 7.5 18.7 3.2 7.0 13.0 1.3 1 0 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS55903.1 - 1.4e-131 438.2 5.5 2.2e-131 437.5 3.8 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55903.1 - 4.3e-09 36.0 13.2 4.3e-09 36.0 9.1 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_C PF11040.3 ESS55906.1 - 8e-35 118.5 1.6 1.5e-34 117.7 1.1 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS55906.1 - 7.5e-12 45.0 1.6 7.5e-12 45.0 1.1 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 PTS_EIIC PF02378.13 ESS55906.1 - 0.0093 14.8 1.7 0.013 14.3 0.2 1.8 2 0 0 2 2 2 1 Phosphotransferase system, EIIC YfhO PF09586.5 ESS55906.1 - 0.32 8.9 0.9 0.38 8.7 0.6 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SID-1_RNA_chan PF13965.1 ESS55906.1 - 0.45 8.6 4.2 0.67 8.0 2.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Glycos_transf_4 PF00953.16 ESS55906.1 - 0.98 9.1 11.0 2.5 7.8 7.4 1.8 1 1 1 2 2 2 0 Glycosyl transferase family 4 BNR_3 PF13859.1 ESS55909.1 - 1.3e-119 398.8 4.5 2e-119 398.2 3.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55909.1 - 4.6e-09 35.9 0.1 7.5e-09 35.2 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55910.1 - 4.2e-17 62.8 0.5 4.2e-17 62.8 0.3 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55910.1 - 8.5e-10 38.3 13.2 1.8e-09 37.3 9.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal FAM163 PF15069.1 ESS55911.1 - 0.057 13.9 0.0 0.076 13.5 0.0 1.1 1 0 0 1 1 1 0 FAM163 family BNR_3 PF13859.1 ESS55912.1 - 1.8e-131 437.8 4.7 1.8e-131 437.8 3.3 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55912.1 - 7.9e-16 58.6 0.2 3.2e-15 56.7 0.1 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55912.1 - 1.1e-07 31.6 11.4 1.1e-07 31.6 7.9 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Copper-fist PF00649.13 ESS55913.1 - 6.2 6.1 7.2 1.3 8.3 1.6 2.3 2 0 0 2 2 2 0 Copper fist DNA binding domain DUF3720 PF12517.3 ESS55915.1 - 2.1e-27 95.6 19.8 2.1e-27 95.6 13.7 3.9 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) Nop14 PF04147.7 ESS55915.1 - 9.2 4.0 14.6 12 3.7 10.1 1.2 1 0 0 1 1 1 0 Nop14-like family DUF707 PF05212.7 ESS55916.1 - 0.073 12.1 0.6 0.11 11.6 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF707) BNR_3 PF13859.1 ESS55918.1 - 3.5e-66 223.3 0.0 5.6e-66 222.7 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55918.1 - 6.4e-11 41.9 11.8 2.2e-10 40.2 8.2 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS55918.1 - 8.3e-11 42.3 0.0 3.2e-10 40.4 0.0 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS55918.1 - 1.9e-05 24.1 0.1 0.014 14.6 0.1 3.1 3 1 1 4 4 4 3 BNR repeat-like domain BNR PF02012.15 ESS55918.1 - 0.00017 20.8 2.8 0.57 10.2 0.2 3.3 2 0 0 2 2 2 2 BNR/Asp-box repeat SOG2 PF10428.4 ESS55918.1 - 0.1 11.2 1.7 0.14 10.7 1.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DGF-1_5 PF11038.3 ESS55920.1 - 1.6e-160 532.7 17.8 1.6e-160 532.7 12.3 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS55920.1 - 1.2e-40 137.7 17.2 4.4e-40 135.9 11.9 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF3676 PF12429.3 ESS55925.1 - 4.8e-104 347.0 45.8 7.6e-104 346.3 31.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS55925.1 - 1.6e-81 273.8 0.2 1.6e-81 273.8 0.1 2.2 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS55925.1 - 1.3e-08 34.4 7.8 2.8e-08 33.4 5.4 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal ABC2_membrane_3 PF12698.2 ESS55926.1 - 0.64 8.9 4.5 0.72 8.8 3.1 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1360 PF07098.6 ESS55927.1 - 0.025 14.3 0.0 0.025 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zf-ribbon_3 PF13248.1 ESS55927.1 - 0.97 8.7 3.8 0.59 9.4 0.9 1.9 2 1 0 2 2 2 0 zinc-ribbon domain DUF3676 PF12429.3 ESS55928.1 - 9.2e-73 244.6 25.7 9.2e-73 244.6 17.8 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS55928.1 - 3.1e-11 42.9 5.6 4.7e-11 42.3 3.9 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS55929.1 - 1.3e-18 67.7 0.4 1.3e-18 67.7 0.3 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Na_trans_assoc PF06512.8 ESS55929.1 - 0.6 10.0 3.3 1.1 9.1 2.3 1.4 1 0 0 1 1 1 0 Sodium ion transport-associated DUF605 PF04652.11 ESS55929.1 - 1.3 8.2 9.5 1.9 7.7 6.6 1.1 1 0 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS55930.1 - 5.2e-130 433.0 7.5 6.3e-130 432.7 5.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55930.1 - 4e-05 23.0 0.1 6.5e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain RVT_1 PF00078.22 ESS55931.1 - 2.1e-09 37.0 0.0 3.2e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS55931.1 - 3.2e-09 37.2 0.0 5.5e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 RNase H DUF2509 PF10713.4 ESS55931.1 - 0.062 13.0 2.2 0.55 9.9 0.5 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2509) RVT_3 PF13456.1 ESS55931.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase-like BNR_3 PF13859.1 ESS55933.1 - 1.4e-129 431.5 4.5 2.6e-129 430.7 3.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55933.1 - 5.9e-15 55.8 1.5 5.9e-15 55.8 1.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55933.1 - 4.4e-10 39.2 7.5 4.4e-10 39.2 5.2 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS55937.1 - 1.9e-28 99.0 13.3 1.9e-28 99.0 9.2 4.1 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS55938.1 - 2.1e-129 431.0 4.6 2.1e-129 431.0 3.2 2.2 2 1 1 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55938.1 - 2.9e-16 60.1 0.4 9.8e-16 58.3 0.3 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55938.1 - 2.2e-08 33.7 7.3 2.2e-08 33.7 5.1 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS55938.1 - 0.00068 19.0 0.1 0.002 17.4 0.0 1.8 1 0 0 1 1 1 1 BNR repeat-like domain ASRT PF07100.6 ESS55939.1 - 0.0082 15.8 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Anabaena sensory rhodopsin transducer DUF1623 PF07785.6 ESS55939.1 - 0.035 14.0 0.2 0.054 13.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) Corona_S2 PF01601.11 ESS55939.1 - 0.07 11.2 1.8 0.091 10.8 1.3 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Acetyltransf_1 PF00583.19 ESS55941.1 - 1.8e-11 43.9 0.1 3e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESS55941.1 - 1.2e-05 25.3 0.0 2.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESS55941.1 - 0.0011 18.6 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 ESS55941.1 - 0.0055 16.8 0.0 0.015 15.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESS55941.1 - 0.044 13.6 0.0 0.22 11.4 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF2968 PF11180.3 ESS55942.1 - 0.16 11.3 3.7 0.15 11.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) FlaC_arch PF05377.6 ESS55942.1 - 0.22 11.4 5.5 7.7 6.4 0.0 4.4 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) DUF1663 PF07909.6 ESS55944.1 - 3e-179 596.6 12.0 3.7e-179 596.4 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1663) ASF1_hist_chap PF04729.8 ESS55945.1 - 0.049 13.2 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 ASF1 like histone chaperone WD40 PF00400.27 ESS55946.1 - 0.00067 19.4 0.8 8.5 6.4 0.0 4.6 5 1 0 5 5 5 2 WD domain, G-beta repeat IBR PF01485.16 ESS55947.1 - 4.4e-11 42.4 50.3 1.1e-06 28.4 10.5 4.9 3 2 1 4 4 4 2 IBR domain zf-RING_2 PF13639.1 ESS55947.1 - 0.00025 20.7 7.6 0.00025 20.7 5.2 4.3 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.1 ESS55947.1 - 0.0039 16.8 7.8 0.0039 16.8 5.4 4.7 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESS55947.1 - 0.0042 17.0 8.2 0.0042 17.0 5.7 5.4 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) AAA PF00004.24 ESS55948.1 - 4.3e-52 175.7 0.0 5.5e-41 139.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS55948.1 - 1.1e-07 32.0 0.2 0.047 13.6 0.0 3.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 ESS55948.1 - 2.7e-06 27.5 0.1 0.27 11.3 0.0 3.4 2 1 1 3 3 3 2 AAA domain AAA_5 PF07728.9 ESS55948.1 - 1.7e-05 24.5 0.0 0.023 14.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESS55948.1 - 5.6e-05 22.2 0.0 0.00036 19.6 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESS55948.1 - 0.00011 21.6 0.1 0.81 9.0 0.0 3.2 4 0 0 4 4 3 2 AAA domain NACHT PF05729.7 ESS55948.1 - 0.00013 21.7 0.0 0.4 10.3 0.0 3.0 3 0 0 3 3 3 2 NACHT domain RNA_helicase PF00910.17 ESS55948.1 - 0.0014 18.7 0.0 0.31 11.2 0.0 2.6 2 0 0 2 2 2 1 RNA helicase TIP49 PF06068.8 ESS55948.1 - 0.0023 16.7 0.0 0.0051 15.5 0.0 1.6 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESS55948.1 - 0.0027 17.1 0.0 0.11 11.9 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.9 ESS55948.1 - 0.0051 16.7 0.0 0.059 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.22 ESS55948.1 - 0.0065 16.7 0.0 0.78 10.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter Mg_chelatase PF01078.16 ESS55948.1 - 0.0099 15.0 0.0 0.068 12.3 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESS55948.1 - 0.0099 15.3 0.0 5 6.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.1 ESS55948.1 - 0.012 15.4 0.0 1.3 8.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.5 ESS55948.1 - 0.021 14.6 0.0 0.081 12.8 0.0 2.0 2 0 0 2 2 1 0 Vps4 C terminal oligomerisation domain DUF815 PF05673.8 ESS55948.1 - 0.021 13.7 0.0 2 7.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.1 ESS55948.1 - 0.029 13.9 0.0 2.3 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESS55948.1 - 0.033 14.1 0.0 0.58 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESS55948.1 - 0.046 13.1 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Sigma54_activ_2 PF14532.1 ESS55948.1 - 0.047 13.7 0.0 0.4 10.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_17 PF13207.1 ESS55948.1 - 0.055 14.2 0.0 0.62 10.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESS55948.1 - 0.098 11.7 0.0 0.3 10.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.10 ESS55948.1 - 0.12 11.0 0.0 0.27 9.8 0.0 1.5 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 ESS55948.1 - 0.2 11.3 0.0 5.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Archaeal ATPase RskA PF10099.4 ESS55949.1 - 1.9 8.2 6.0 2.9 7.5 4.1 1.5 1 1 0 1 1 1 0 Anti-sigma-K factor rskA BNR_3 PF13859.1 ESS55953.1 - 1.4e-119 398.7 7.1 1.4e-119 398.7 4.9 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55953.1 - 3.3e-14 53.4 0.1 9.4e-14 51.9 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55953.1 - 2.6e-09 36.7 15.4 5.7e-09 35.6 10.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS55953.1 - 4.4e-05 22.8 0.0 0.00011 21.6 0.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain DUF3664 PF12406.3 ESS55954.1 - 0.053 14.1 0.9 0.053 14.1 0.6 2.1 1 1 1 2 2 2 0 Surface protein DUF2463 PF09591.5 ESS55955.1 - 0.0049 16.4 0.0 0.008 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) GPCR_chapero_1 PF11904.3 ESS55955.1 - 3.3 6.7 6.2 2.2 7.3 3.0 1.5 2 0 0 2 2 2 0 GPCR-chaperone BNR_3 PF13859.1 ESS55959.1 - 6.4e-130 432.7 5.4 7.5e-130 432.5 3.7 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS55959.1 - 0.0012 18.1 0.2 0.0017 17.6 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain RVT_1 PF00078.22 ESS55963.1 - 0.00058 19.2 0.0 0.00078 18.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4019 PF13211.1 ESS55966.1 - 0.36 11.0 2.0 0.85 9.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4019) SRP-alpha_N PF04086.8 ESS55966.1 - 0.61 9.4 3.7 0.78 9.0 2.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2574 PF10836.3 ESS55966.1 - 0.62 9.8 5.0 6.1 6.6 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2574) Mucin PF01456.12 ESS55969.1 - 5.4e-36 123.4 41.0 2.3e-35 121.4 28.4 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein DNA_pol_viral_N PF00242.12 ESS55969.1 - 0.091 11.7 2.6 0.12 11.3 1.8 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF4658 PF15555.1 ESS55969.1 - 0.11 12.3 0.2 0.11 12.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) SpoIIIAH PF12685.2 ESS55969.1 - 4.2 6.8 10.3 1.2e+02 2.0 7.1 2.3 1 1 0 1 1 1 0 SpoIIIAH-like protein NAD_binding_1 PF00175.16 ESS55972.1 - 2.4e-28 98.8 0.0 3.9e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESS55972.1 - 9.4e-25 86.6 0.0 1.5e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESS55972.1 - 1.8e-05 24.7 0.0 0.001 18.9 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain AAA PF00004.24 ESS55973.1 - 3e-42 143.9 0.0 6.3e-42 142.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESS55973.1 - 6.6e-07 29.4 0.0 1.4e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESS55973.1 - 2.8e-06 27.5 0.3 0.00042 20.4 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS55973.1 - 2.4e-05 24.1 0.1 9.2e-05 22.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS55973.1 - 3.4e-05 23.9 0.0 0.00019 21.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 ESS55973.1 - 0.00021 20.2 0.0 0.00037 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESS55973.1 - 0.0003 19.9 0.0 0.00056 19.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESS55973.1 - 0.0019 18.0 0.0 0.0037 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS55973.1 - 0.0034 18.1 0.1 0.0092 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS55973.1 - 0.0047 16.8 0.0 0.0094 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 ESS55973.1 - 0.0068 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ESS55973.1 - 0.0074 15.9 0.1 0.41 10.2 0.1 2.5 2 1 1 3 3 2 1 NACHT domain AAA_19 PF13245.1 ESS55973.1 - 0.0085 15.8 0.5 0.018 14.8 0.4 1.4 1 0 0 1 1 1 1 Part of AAA domain KaiC PF06745.8 ESS55973.1 - 0.0087 15.2 0.2 0.2 10.7 0.1 2.3 1 1 1 2 2 2 1 KaiC IstB_IS21 PF01695.12 ESS55973.1 - 0.01 15.2 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 ESS55973.1 - 0.012 15.9 0.0 0.028 14.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESS55973.1 - 0.016 15.3 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.17 ESS55973.1 - 0.017 14.0 0.0 0.061 12.1 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_28 PF13521.1 ESS55973.1 - 0.017 15.0 0.3 0.075 12.9 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.1 ESS55973.1 - 0.037 13.4 0.9 2 7.7 0.2 2.3 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.4 ESS55973.1 - 0.044 12.7 1.1 0.11 11.4 0.2 2.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.7 ESS55973.1 - 0.049 12.7 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin TIP49 PF06068.8 ESS55973.1 - 0.061 12.0 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.16 ESS55973.1 - 0.091 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.13 ESS55973.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PhoH PF02562.11 ESS55973.1 - 0.11 11.6 0.3 0.44 9.7 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein PAP2 PF01569.16 ESS55974.1 - 2.7 7.6 8.6 0.16 11.6 1.9 1.9 2 0 0 2 2 2 0 PAP2 superfamily BNR_3 PF13859.1 ESS55975.1 - 4.7e-122 406.9 4.5 1.1e-121 405.7 3.1 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55975.1 - 3.5e-18 66.3 0.6 3.5e-18 66.3 0.4 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55975.1 - 4.1e-07 29.7 11.5 8.5e-07 28.7 8.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Lin-8 PF03353.10 ESS55978.1 - 2.4 7.3 7.6 3.6 6.7 5.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Laminin_G_3 PF13385.1 ESS55980.1 - 3e-14 53.5 0.1 4.2e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55980.1 - 6.1e-08 32.3 11.9 6.1e-08 32.3 8.3 1.7 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS55981.1 - 2.7e-57 194.1 1.7 3.4e-57 193.8 1.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS55982.1 - 3.3e-20 72.8 0.6 8.4e-20 71.5 0.4 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS55982.1 - 2.1e-11 43.4 11.8 4.8e-11 42.3 8.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C4pol PF14260.1 ESS55983.1 - 0.048 13.6 1.1 0.078 12.9 0.8 1.5 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta DUF2161 PF09929.4 ESS55983.1 - 0.053 13.4 0.1 0.06 13.2 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2161) Selenoprotein_S PF06936.6 ESS55983.1 - 0.066 12.7 2.1 0.087 12.3 1.4 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) HutP PF09021.6 ESS55983.1 - 0.11 12.6 0.5 0.15 12.3 0.4 1.1 1 0 0 1 1 1 0 HutP BNR_3 PF13859.1 ESS55984.1 - 1.2e-14 54.1 0.0 2.4e-14 53.1 0.0 1.6 1 1 0 1 1 1 1 BNR repeat-like domain Amb_V_allergen PF03913.8 ESS55984.1 - 0.16 11.7 0.0 0.16 11.7 0.0 2.5 3 0 0 3 3 3 0 Amb V Allergen DUF4220 PF13968.1 ESS55985.1 - 0.075 12.1 0.1 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF4407 PF14362.1 ESS55985.1 - 0.21 10.4 6.8 0.3 9.9 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Herpes_DNAp_acc PF04929.7 ESS56173.1 - 1.2 8.0 3.6 1.5 7.6 2.4 1.3 1 1 0 1 1 1 0 Herpes DNA replication accessory factor PSI PF01437.20 ESS56173.1 - 4.9 7.3 13.8 7 6.8 0.5 2.7 2 1 0 2 2 2 0 Plexin repeat Mucin PF01456.12 ESS56174.1 - 3e-35 121.0 37.1 1.1e-34 119.2 25.7 1.9 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS56174.1 - 0.076 12.8 0.5 0.076 12.8 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) DNA_pol_viral_N PF00242.12 ESS56174.1 - 0.22 10.5 3.1 0.29 10.0 2.2 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF3138 PF11336.3 ESS56175.1 - 1.1 7.4 7.6 1.1 7.3 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF3597 PF12200.3 ESS56175.1 - 5.4 7.4 10.4 6.6 7.1 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) CDC27 PF09507.5 ESS56176.1 - 0.097 11.8 5.9 0.11 11.7 4.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Daxx PF03344.10 ESS56177.1 - 0.026 13.0 23.6 0.03 12.8 16.4 1.1 1 0 0 1 1 1 0 Daxx Family Menin PF05053.8 ESS56177.1 - 0.1 10.7 10.7 0.13 10.4 7.4 1.3 1 0 0 1 1 1 0 Menin Plasmodium_Vir PF05795.6 ESS56177.1 - 0.31 10.1 7.5 0.53 9.4 5.2 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Utp14 PF04615.8 ESS56177.1 - 0.41 8.7 25.0 0.51 8.4 17.3 1.1 1 0 0 1 1 1 0 Utp14 protein Peptidase_S64 PF08192.6 ESS56177.1 - 2.5 6.3 12.1 3.4 5.8 8.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ycf1 PF05758.7 ESS56177.1 - 2.7 5.5 10.0 3.1 5.3 6.9 1.1 1 0 0 1 1 1 0 Ycf1 BNR_3 PF13859.1 ESS56178.1 - 3.4e-75 252.9 1.8 3.6e-74 249.6 0.9 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Vac7 PF12751.2 ESS56178.1 - 0.046 12.5 0.3 0.074 11.8 0.2 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Laminin_G_3 PF13385.1 ESS56179.1 - 2.3e-17 63.6 0.7 3.3e-17 63.1 0.1 1.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS56179.1 - 1.4e-09 37.6 12.3 1.9e-09 37.2 7.6 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS56179.1 - 0.0042 16.0 0.0 0.0067 15.4 0.0 1.3 1 0 0 1 1 1 1 Sialidase, N-terminal domain Peptidase_M8 PF01457.11 ESS56182.1 - 3.9e-09 35.4 4.7 1.6e-07 30.0 3.3 2.0 1 1 0 1 1 1 1 Leishmanolysin RHSP PF07999.6 ESS56183.1 - 2.3e-14 52.8 0.0 2.8e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS56184.1 - 1.1e-65 222.0 0.1 1.4e-65 221.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS56185.1 - 1.6e-151 503.1 16.5 1.6e-151 503.1 11.4 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS56185.1 - 1.2e-35 121.7 15.6 2.9e-35 120.4 10.8 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 ArfGap PF01412.13 ESS56257.1 - 0.11 12.3 0.9 0.15 11.8 0.6 1.3 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf BNR_3 PF13859.1 ESS56258.1 - 4.8e-130 433.1 4.9 4.8e-130 433.1 3.4 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS56258.1 - 2.8e-18 66.6 0.5 7.1e-18 65.3 0.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS56258.1 - 0.00037 19.8 0.1 0.00073 18.9 0.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS56259.1 - 4.1e-14 53.1 0.2 4.1e-14 53.1 0.1 2.3 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS56259.1 - 4.4e-10 39.2 6.9 1.1e-09 38.0 4.8 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS56260.1 - 0.0011 18.7 23.4 0.0096 15.6 16.2 2.3 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF1942 PF09167.6 ESS56260.1 - 0.079 12.7 0.4 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1942) DUF605 PF04652.11 ESS56262.1 - 2.6 7.3 11.5 3.2 7.0 8.0 1.1 1 0 0 1 1 1 0 Vta1 like MAP65_ASE1 PF03999.7 ESS56262.1 - 9.2 4.7 8.9 10 4.5 6.2 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BNR_3 PF13859.1 ESS56263.1 - 4.5e-51 173.7 1.4 6.7e-51 173.2 0.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain DUF3676 PF12429.3 ESS56263.1 - 8.6e-21 74.6 7.9 1.4e-20 73.9 5.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Laminin_G_3 PF13385.1 ESS56263.1 - 3.8e-13 49.9 0.6 1.1e-12 48.4 0.4 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 ESS56263.1 - 0.071 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Laminin G domain DUF3676 PF12429.3 ESS56264.1 - 4.2e-69 232.6 31.7 7.1e-69 231.9 22.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS56264.1 - 2e-08 33.9 2.8 3.1e-08 33.3 1.9 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MG1 PF11974.3 ESS56264.1 - 2.1 8.9 5.2 0.79 10.3 1.5 2.1 2 1 0 2 2 2 0 Alpha-2-macroglobulin MG1 domain PIG-P PF08510.7 ESS56265.1 - 3.5 7.2 5.5 0.62 9.6 0.7 2.0 2 0 0 2 2 2 0 PIG-P Bd3614-deam PF14439.1 ESS56268.1 - 0.38 10.6 3.3 15 5.3 0.5 2.5 2 0 0 2 2 2 0 Bd3614-like deaminase BNR_3 PF13859.1 ESS56269.1 - 2.8e-128 427.3 7.8 5.5e-128 426.3 5.4 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS56269.1 - 2.8e-14 53.6 1.6 5.2e-14 52.7 0.2 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Daxx PF03344.10 ESS56271.1 - 3.8 5.8 38.0 5.4 5.3 26.4 1.1 1 0 0 1 1 1 0 Daxx Family DUF1360 PF07098.6 ESS56272.1 - 0.032 13.9 0.1 0.037 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zf-ribbon_3 PF13248.1 ESS56272.1 - 1.8 7.9 4.7 0.83 8.9 1.4 1.9 2 1 0 2 2 2 0 zinc-ribbon domain BNR_3 PF13859.1 ESS56273.1 - 5e-131 436.3 6.2 5e-131 436.3 4.3 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS56273.1 - 7.9e-14 52.1 0.1 2.7e-13 50.4 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS56273.1 - 5.3e-10 38.9 7.9 1.4e-09 37.6 5.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PIG-U PF06728.8 ESS56274.1 - 0.0095 14.8 0.1 0.011 14.6 0.1 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U UPF0542 PF15086.1 ESS56274.1 - 0.15 11.8 0.3 0.25 11.0 0.2 1.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0542 RNase_H PF00075.19 ESS56275.1 - 3.1e-11 43.7 0.0 5.1e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS56275.1 - 0.053 12.9 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 DAN domain DUF2509 PF10713.4 ESS56275.1 - 0.11 12.3 1.5 0.79 9.4 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2509) Beta_helix PF13229.1 ESS56277.1 - 5.2e-08 32.8 1.5 7.5e-06 25.7 0.2 2.2 1 1 1 2 2 2 2 Right handed beta helix region TIG PF01833.19 ESS56277.1 - 0.0062 16.5 0.4 0.11 12.5 0.0 2.7 1 1 1 2 2 2 1 IPT/TIG domain DUF1010 PF06231.6 ESS56277.1 - 0.026 14.5 1.2 0.042 13.8 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1010) NosD PF05048.8 ESS56277.1 - 0.091 11.8 0.5 0.67 9.0 0.6 1.9 1 1 1 2 2 2 0 Periplasmic copper-binding protein (NosD) Oxidored_q3 PF00499.15 ESS56895.1 - 2.2 8.0 14.9 2.6 7.8 10.3 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF3676 PF12429.3 ESS56896.1 - 9e-100 333.0 42.1 1.4e-99 332.3 29.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS56896.1 - 1.3e-79 267.4 4.2 1.7e-79 267.1 0.0 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS56896.1 - 1e-09 38.8 1.3 1e-09 38.8 0.9 2.8 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS56896.1 - 2.7e-09 36.7 5.3 5.9e-09 35.6 3.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal GSK-3_bind PF05350.7 ESS56899.1 - 0.078 12.4 2.8 0.19 11.1 2.0 1.7 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding RHSP PF07999.6 ESS56900.1 - 3.6e-108 361.9 1.8 5.5e-108 361.3 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein MIR PF02815.14 ESS56901.1 - 0.0023 17.4 3.3 0.003 17.1 2.3 1.3 1 0 0 1 1 1 1 MIR domain DUF2076 PF09849.4 ESS56901.1 - 0.0036 17.4 0.0 0.0041 17.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) MGC-24 PF05283.6 ESS56901.1 - 1.1 9.0 5.2 1.2 8.8 3.6 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) BNR_3 PF13859.1 ESS56903.1 - 4.7e-65 219.6 0.6 1.2e-64 218.3 0.4 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS56903.1 - 2e-19 70.3 0.6 4.9e-19 69.1 0.3 1.7 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS56903.1 - 1e-07 31.6 11.3 1e-07 31.6 7.8 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PEGA PF08308.6 ESS56903.1 - 0.058 13.1 0.1 0.41 10.4 0.0 2.4 2 0 0 2 2 2 0 PEGA domain RVT_1 PF00078.22 ESS56906.1 - 1.5e-21 76.7 0.0 2.5e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Uds1 PF15456.1 ESS56910.1 - 0.00083 19.3 11.3 0.00083 19.3 7.8 8.8 3 2 6 9 9 9 3 Up-regulated During Septation Snapin_Pallidin PF14712.1 ESS56911.1 - 0.026 14.8 1.0 0.026 14.8 0.7 4.7 5 1 1 6 6 6 0 Snapin/Pallidin Laminin_II PF06009.7 ESS56911.1 - 0.048 13.4 16.3 0.064 13.0 1.9 3.4 1 1 2 3 3 3 0 Laminin Domain II FliD_C PF07195.7 ESS56911.1 - 0.63 9.2 10.0 3.3 6.9 1.1 3.0 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus NYN_YacP PF05991.6 ESS56911.1 - 2.5 7.8 10.3 0.074 12.7 0.5 2.8 2 1 1 3 3 3 0 YacP-like NYN domain DUF1664 PF07889.7 ESS56911.1 - 4.1 7.2 21.7 0.27 11.0 2.4 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) PCI PF01399.22 ESS56911.1 - 9.6 6.5 11.8 2.8 8.2 0.9 3.5 2 1 0 3 3 3 0 PCI domain Hexapep PF00132.19 ESS56912.1 - 2.3e-11 42.6 9.4 0.00084 18.7 0.0 4.4 3 1 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NOB1_Zn_bind PF08772.6 ESS56913.1 - 2.4e-26 91.3 1.4 4.4e-26 90.4 1.0 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like AF1Q PF15017.1 ESS56913.1 - 0.00014 21.6 3.7 0.00027 20.8 2.6 1.4 1 0 0 1 1 1 1 Drug resistance and apoptosis regulator zf-NADH-PPase PF09297.6 ESS56913.1 - 0.33 10.4 4.2 0.69 9.4 0.9 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain ACC_epsilon PF13822.1 ESS56913.1 - 1.2 9.4 3.4 2.6 8.4 0.0 2.8 3 0 0 3 3 3 0 Acyl-CoA carboxylase epsilon subunit BNR_3 PF13859.1 ESS57052.1 - 5.5e-133 442.8 3.7 1e-132 441.9 2.6 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS57052.1 - 3e-13 50.2 5.6 6.3e-13 49.2 2.8 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF3720 PF12517.3 ESS57140.1 - 7.7e-26 90.6 16.7 7.7e-26 90.6 11.5 3.9 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS57141.1 - 7.8e-132 439.0 4.7 7.8e-132 439.0 3.3 2.7 3 0 0 3 3 3 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS57141.1 - 5.8e-17 62.3 0.4 1.9e-16 60.7 0.3 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS57141.1 - 5e-09 35.8 11.7 1.3e-08 34.5 8.1 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RVT_1 PF00078.22 ESS57143.1 - 9.8e-27 93.7 0.0 1.3e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS57143.1 - 0.018 14.8 0.5 0.18 11.6 0.1 2.5 3 0 0 3 3 3 0 EBP50, C-terminal DGF-1_5 PF11038.3 ESS57144.1 - 1.9e-47 161.8 11.4 1.9e-47 161.8 7.9 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS57144.1 - 1.2e-35 121.2 1.5 2.3e-35 120.2 1.0 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Glycos_transf_4 PF00953.16 ESS57144.1 - 0.0099 15.6 3.1 0.0099 15.6 2.2 2.3 2 1 0 2 2 2 1 Glycosyl transferase family 4 DUF3568 PF12092.3 ESS57145.1 - 1.2 8.8 3.5 17 5.1 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3568) RVT_1 PF00078.22 ESS57532.1 - 1.7e-30 106.0 0.0 3.7e-30 104.8 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS57532.1 - 0.046 13.5 0.2 0.16 11.8 0.1 1.9 2 0 0 2 2 2 0 EBP50, C-terminal DUF2826 PF11442.3 ESS57534.1 - 5.8e-92 305.6 10.8 7.6e-92 305.2 7.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) BNR_3 PF13859.1 ESS57535.1 - 1.6e-128 428.1 1.2 1.6e-128 428.1 0.8 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS57535.1 - 1.4e-15 57.8 1.7 2.9e-15 56.8 0.2 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS57535.1 - 1.1e-09 37.9 13.3 3.1e-09 36.5 9.2 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2702 PF10863.3 ESS57536.1 - 0.016 14.8 2.7 1.2 8.9 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2702) AMPKBI PF04739.10 ESS57536.1 - 0.075 12.8 0.3 0.18 11.6 0.2 1.6 1 0 0 1 1 1 0 5'-AMP-activated protein kinase beta subunit, interation domain YABBY PF04690.8 ESS57537.1 - 3.6 7.8 8.4 1.1 9.5 0.0 3.0 3 0 0 3 3 3 0 YABBY protein TFIIS_C PF01096.13 ESS57718.1 - 0.0018 17.8 1.3 0.0024 17.4 0.1 1.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) zf-ISL3 PF14690.1 ESS57718.1 - 0.19 11.7 3.2 0.2 11.6 1.2 1.8 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 RHSP PF07999.6 ESS57719.1 - 8.4e-29 100.4 0.0 1.3e-28 99.8 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS57720.1 - 1.4e-105 352.4 22.9 1.4e-105 352.4 15.9 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS57720.1 - 7.1e-48 160.4 0.3 1.5e-47 159.3 0.2 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus hEGF PF12661.2 ESS57722.1 - 0.13 12.3 2.0 0.37 10.9 1.4 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.8 ESS57722.1 - 3.2 7.9 11.2 11 6.3 7.8 1.9 1 1 0 1 1 1 0 EGF-like domain DUF1767 PF08585.7 ESS57725.1 - 0.037 14.2 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1767) Ribosomal_L12 PF00542.14 ESS57725.1 - 0.99 9.4 4.3 1.3 9.1 0.1 2.9 3 0 0 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain Aida_N PF08910.5 ESS57725.1 - 1.3 9.2 6.4 3.1 8.0 0.7 2.7 1 1 1 2 2 2 0 Aida N-terminus Peptidase_M8 PF01457.11 ESS57727.1 - 4.9e-11 41.6 10.4 1.4e-09 36.8 7.2 2.0 1 1 0 1 1 1 1 Leishmanolysin BNR_3 PF13859.1 ESS57728.1 - 1.2e-132 441.6 4.8 2.9e-132 440.4 3.3 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS57728.1 - 3e-17 63.3 0.0 1.2e-16 61.3 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS57728.1 - 3.1e-08 33.3 7.2 3.1e-08 33.3 5.0 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS58061.1 - 1.5e-96 323.1 2.8 1.5e-96 323.1 2.0 2.4 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58061.1 - 9.4e-21 74.6 0.6 2.3e-20 73.4 0.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58061.1 - 1.8e-12 46.8 11.7 4.3e-12 45.6 8.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS58062.1 - 2.2e-98 329.6 0.5 2.8e-98 329.3 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS58063.1 - 7.8e-29 100.7 0.2 2.2e-28 99.2 0.1 1.8 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58063.1 - 1.1e-15 58.1 1.1 1.8e-15 57.5 0.8 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58063.1 - 4.6e-10 39.1 10.8 1e-09 38.0 7.5 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal SUR7 PF06687.7 ESS58064.1 - 0.002 17.7 5.4 0.0025 17.4 3.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF4191 PF13829.1 ESS58064.1 - 0.073 12.1 10.2 0.11 11.6 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) FdtA PF05523.6 ESS58064.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 WxcM-like, C-terminal DUF3464 PF11947.3 ESS58064.1 - 0.1 12.0 3.2 0.12 11.8 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) FA_desaturase PF00487.19 ESS58064.1 - 0.39 10.1 3.7 0.52 9.7 2.6 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DUF1469 PF07332.6 ESS58064.1 - 1.2 8.8 17.4 1.8 8.2 12.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) DUF1700 PF08006.6 ESS58064.1 - 7.3 5.8 14.1 11 5.2 9.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Peptidase_M8 PF01457.11 ESS58065.1 - 1.5e-42 145.7 0.5 1.6e-42 145.5 0.3 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESS58065.1 - 0.048 13.3 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Matrixin Astacin PF01400.19 ESS58065.1 - 0.09 12.1 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.1 ESS58065.1 - 0.13 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 BNR_3 PF13859.1 ESS58066.1 - 6.3e-73 245.5 0.9 6.3e-73 245.5 0.6 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58066.1 - 3.5e-20 72.8 0.8 8.3e-20 71.6 0.5 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58066.1 - 6.6e-09 35.4 8.4 1.3e-08 34.5 5.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS58067.1 - 5.7e-161 534.1 17.0 5.7e-161 534.1 11.8 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS58067.1 - 1.7e-46 156.0 1.0 1.7e-46 156.0 0.7 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS58067.1 - 2.9e-33 114.0 15.5 1.1e-32 112.2 10.7 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Exo_endo_phos PF03372.18 ESS58068.1 - 1.1e-05 25.5 0.1 6e-05 23.1 0.0 1.9 1 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Peptidase_M8 PF01457.11 ESS58247.1 - 1.5e-107 360.0 8.6 1.3e-106 357.0 5.9 1.9 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS58247.1 - 5e-10 39.0 10.2 5e-10 39.0 7.1 2.6 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS58247.1 - 0.06 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Matrixin Galactosyl_T PF01762.16 ESS58248.1 - 5.2e-08 32.7 0.0 0.01 15.4 0.0 3.6 3 1 0 4 4 4 2 Galactosyltransferase RVT_1 PF00078.22 ESS58249.1 - 2.7e-17 62.8 0.0 3.7e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tubulin_C PF03953.12 ESS58250.1 - 4.5e-32 110.7 0.0 6.9e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain BNR_3 PF13859.1 ESS58348.1 - 1.8e-125 418.1 3.4 4.6e-125 416.7 2.4 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58348.1 - 3e-17 63.2 0.3 9.4e-17 61.6 0.2 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58348.1 - 6.3e-10 38.7 6.1 6.3e-10 38.7 4.2 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS58350.1 - 0.028 13.0 1.9 0.099 11.2 0.0 2.0 2 0 0 2 2 2 0 Retrotransposon hot spot protein Ribosomal_L12 PF00542.14 ESS58352.1 - 0.2 11.6 0.9 0.54 10.2 0.2 2.0 1 1 1 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain IncA PF04156.9 ESS58352.1 - 6.7 6.2 6.3 7.4 6.1 4.4 1.1 1 0 0 1 1 1 0 IncA protein DUF1360 PF07098.6 ESS58353.1 - 0.043 13.5 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zf-ribbon_3 PF13248.1 ESS58353.1 - 0.5 9.6 3.9 0.27 10.4 0.9 1.9 2 1 0 2 2 2 0 zinc-ribbon domain BNR_3 PF13859.1 ESS58354.1 - 1.3e-65 221.4 0.1 1.9e-65 220.9 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS58354.1 - 0.34 10.9 2.1 1.1 9.3 0.2 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS58355.1 - 7.1e-06 25.3 0.0 1.4e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 BNR repeat-like domain DGF-1_5 PF11038.3 ESS58661.1 - 6.6e-134 445.4 21.1 6.6e-134 445.4 14.6 1.7 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS58661.1 - 9.1e-47 156.8 2.1 2.4e-46 155.5 1.4 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF1129 PF06570.6 ESS58661.1 - 0.36 10.0 4.3 0.24 10.6 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) DGF-1_4 PF11024.3 ESS58662.1 - 3.1e-20 72.3 8.8 1.2e-19 70.4 6.1 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS58663.1 - 1.1e-81 274.7 0.0 1.9e-81 273.8 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF702 PF05142.7 ESS58664.1 - 0.58 10.3 4.0 0.65 10.1 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) BNR_3 PF13859.1 ESS58665.1 - 1e-63 215.2 1.3 3.5e-63 213.5 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58665.1 - 9.8e-05 22.6 1.3 0.00015 22.0 0.3 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS58753.1 - 8.2e-97 324.5 0.2 1.1e-96 324.1 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS58753.1 - 0.0054 16.8 0.0 2.4 8.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 ESS58753.1 - 0.18 11.1 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain BNR_3 PF13859.1 ESS58754.1 - 2.6e-45 154.8 0.0 4.5e-45 154.0 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58754.1 - 2e-11 44.3 0.0 3.6e-10 40.2 0.0 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58754.1 - 5.4e-06 26.1 7.2 1.2e-05 25.0 5.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS58754.1 - 0.057 12.6 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 BNR repeat-like domain BNR PF02012.15 ESS58754.1 - 0.1 12.4 13.0 0.35 10.8 0.4 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat Tweety PF04906.8 ESS58756.1 - 0.1 10.9 2.7 0.1 11.0 1.9 1.1 1 0 0 1 1 1 0 Tweety RHSP PF07999.6 ESS58798.1 - 1.5e-115 386.3 0.1 2e-115 385.8 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Squash PF00299.13 ESS58798.1 - 1.4 8.7 6.1 0.38 10.6 1.1 2.1 2 0 0 2 2 2 0 Squash family serine protease inhibitor Laminin_G_3 PF13385.1 ESS58799.1 - 9.6e-17 61.6 0.1 1.8e-16 60.7 0.0 1.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58799.1 - 3.6e-07 29.9 5.2 7.1e-07 28.9 3.6 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS58799.1 - 0.00043 19.4 0.0 0.00084 18.4 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS58801.1 - 1.8e-128 428.0 6.1 3.6e-128 427.0 4.2 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58801.1 - 4.2e-16 59.5 0.3 9.8e-16 58.3 0.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58801.1 - 1.7e-09 37.3 14.6 4.1e-09 36.1 10.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal LmjF365940-deam PF14421.1 ESS58802.1 - 0.12 11.8 4.6 0.19 11.1 3.2 1.4 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases Peptidase_M8 PF01457.11 ESS58804.1 - 0.00012 20.6 0.0 0.00019 19.9 0.0 1.3 1 0 0 1 1 1 1 Leishmanolysin BNR_3 PF13859.1 ESS58860.1 - 5.5e-63 212.8 0.3 5.5e-63 212.8 0.2 2.6 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58860.1 - 1.3e-14 54.7 0.3 2.8e-14 53.6 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58860.1 - 9e-11 41.4 11.1 1.8e-10 40.4 7.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Utp14 PF04615.8 ESS58863.1 - 1.3 7.0 28.3 1.8 6.6 19.6 1.1 1 0 0 1 1 1 0 Utp14 protein BNR_3 PF13859.1 ESS58872.1 - 3.9e-67 226.5 0.3 3.9e-67 226.5 0.2 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58872.1 - 6.6e-18 65.4 0.5 1.9e-17 63.9 0.3 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58872.1 - 1.3e-09 37.7 8.5 2.9e-09 36.6 5.9 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS58872.1 - 0.012 15.6 0.1 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain MIR PF02815.14 ESS58873.1 - 0.035 13.6 1.0 0.04 13.4 0.7 1.1 1 0 0 1 1 1 0 MIR domain Recombinase PF07508.8 ESS58874.1 - 0.0042 17.2 0.1 0.0048 17.0 0.1 1.1 1 0 0 1 1 1 1 Recombinase DUF2702 PF10863.3 ESS58874.1 - 0.048 13.3 1.4 0.055 13.1 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2702) PDEase_I_N PF08499.7 ESS58874.1 - 0.27 11.1 1.2 3.6 7.5 0.2 2.1 1 1 1 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal AAA_33 PF13671.1 ESS58876.1 - 0.018 14.9 0.1 0.03 14.2 0.0 1.3 1 1 0 1 1 1 0 AAA domain BNR_3 PF13859.1 ESS58877.1 - 3.7e-94 315.2 3.6 3.7e-94 315.2 2.5 2.2 2 1 0 2 2 2 1 BNR repeat-like domain Alginate_exp PF13372.1 ESS58877.1 - 0.0007 18.3 0.3 0.0011 17.7 0.2 1.1 1 0 0 1 1 1 1 Alginate export Mo-co_dimer PF03404.11 ESS58877.1 - 0.0084 15.7 0.7 0.13 11.8 0.0 2.4 2 0 0 2 2 2 1 Mo-co oxidoreductase dimerisation domain BNR PF02012.15 ESS58877.1 - 0.43 10.6 7.1 4.8 7.4 0.0 4.7 4 0 0 4 4 4 0 BNR/Asp-box repeat Tr-sialidase_C PF11052.3 ESS58927.1 - 2.4e-07 30.4 5.2 2.4e-07 30.4 3.6 2.7 3 0 0 3 3 3 2 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS58927.1 - 3.5e-05 24.1 0.0 7.6e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF384 PF04064.8 ESS58958.1 - 0.094 12.2 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF384) RQC PF09382.5 ESS58959.1 - 0.0084 15.8 0.4 0.012 15.3 0.2 1.3 1 1 0 1 1 1 1 RQC domain Stm1_N PF09598.5 ESS58959.1 - 0.38 11.4 2.4 2.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Stm1 FYVE PF01363.16 ESS58960.1 - 0.35 10.7 5.7 1.9 8.4 4.0 1.9 1 1 0 1 1 1 0 FYVE zinc finger REV PF00424.13 ESS58960.1 - 3 7.8 6.4 3.8 7.4 4.3 1.3 1 1 0 1 1 1 0 REV protein (anti-repression trans-activator protein) RHSP PF07999.6 ESS58963.1 - 8.2e-52 176.2 0.0 1.1e-51 175.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS58968.1 - 3.9e-128 426.8 6.9 6.9e-128 426.0 4.8 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58968.1 - 1.9e-18 67.1 0.2 6.7e-18 65.4 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58968.1 - 6.2e-10 38.7 13.3 1.5e-09 37.5 9.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS58969.1 - 1.7e-161 535.9 19.3 1.7e-161 535.9 13.4 2.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS58969.1 - 4.9e-39 132.5 17.1 1.7e-38 130.8 11.8 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS58969.1 - 1.4e-35 121.0 2.4 4.2e-35 119.4 1.6 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Laminin_G_3 PF13385.1 ESS58971.1 - 3.1e-21 76.2 1.2 7.5e-21 74.9 0.8 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS58971.1 - 3.4e-06 26.8 6.1 8.8e-06 25.4 4.2 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M8 PF01457.11 ESS58972.1 - 8.4e-12 44.2 7.4 3.3e-10 38.9 5.1 2.0 1 1 0 1 1 1 1 Leishmanolysin Nop14 PF04147.7 ESS58973.1 - 0.48 8.2 7.7 0.59 7.9 5.3 1.1 1 0 0 1 1 1 0 Nop14-like family Mucin PF01456.12 ESS58974.1 - 8.3e-38 129.3 48.5 2.2e-35 121.5 33.6 2.2 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF605 PF04652.11 ESS58974.1 - 0.072 12.4 17.2 0.091 12.1 11.9 1.1 1 0 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS58977.1 - 3.7e-74 249.5 0.2 5.2e-74 249.1 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain FA_hydroxylase PF04116.8 ESS58978.1 - 0.1 13.0 2.9 0.51 10.7 2.0 1.9 1 1 0 1 1 1 0 Fatty acid hydroxylase superfamily DUF3168 PF11367.3 ESS58978.1 - 0.11 12.5 0.1 0.15 12.1 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3168) DGF-1_5 PF11038.3 ESS58979.1 - 1.4e-157 523.0 19.6 1.4e-157 523.0 13.6 2.8 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS58979.1 - 3.9e-41 139.3 14.6 1e-40 137.9 10.1 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS58979.1 - 3.6e-33 113.2 2.0 3.6e-33 113.2 1.4 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS58980.1 - 2.4e-41 139.9 17.8 5.2e-41 138.8 12.4 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_5 PF11038.3 ESS58980.1 - 5.9e-38 130.6 0.1 5.9e-38 130.6 0.0 2.9 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS58981.1 - 1.3e-49 165.9 1.2 2.4e-49 165.1 0.8 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS58981.1 - 1.2e-48 165.7 11.1 1.2e-48 165.7 7.7 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 Orbi_NS3 PF01616.11 ESS58981.1 - 0.82 8.6 2.5 3.1 6.7 0.0 2.2 2 0 0 2 2 2 0 Orbivirus NS3 SID-1_RNA_chan PF13965.1 ESS58981.1 - 1.9 6.5 5.2 3 5.9 3.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DGF-1_C PF11040.3 ESS58983.1 - 1.3e-45 153.1 1.4 2.1e-45 152.5 1.0 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS58983.1 - 2.4e-22 79.4 4.5 2.4e-22 79.4 3.1 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DUF3377 PF11857.3 ESS58988.1 - 8.6 6.0 8.2 0.3 10.7 1.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) PROL5-SMR PF15621.1 ESS58990.1 - 2.5 8.5 12.2 4.5 7.7 8.5 1.4 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family IBR PF01485.16 ESS58991.1 - 1.7 8.5 6.0 3.6 7.5 1.0 2.6 2 1 0 2 2 2 0 IBR domain BNR_3 PF13859.1 ESS58992.1 - 6.1e-94 314.5 1.3 9.6e-94 313.9 0.9 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS58992.1 - 1.3e-19 71.0 0.8 2.7e-19 69.9 0.5 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sialidase PF02973.11 ESS58992.1 - 0.064 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Sialidase, N-terminal domain BNR_3 PF13859.1 ESS58993.1 - 9.3e-25 87.3 0.5 1.1e-24 87.1 0.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS58993.1 - 0.21 11.3 1.4 0.31 10.8 1.0 1.4 1 1 0 1 1 1 0 Mucin-like glycoprotein SIR2 PF02146.12 ESS58994.1 - 0.077 12.7 0.1 0.083 12.6 0.0 1.0 1 0 0 1 1 1 0 Sir2 family DGF-1_5 PF11038.3 ESS58995.1 - 1.3e-129 431.2 21.5 1.3e-129 431.2 14.9 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS58996.1 - 3e-41 139.6 17.6 3e-41 139.6 12.2 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RAP1 PF07218.6 ESS59087.1 - 0.051 11.6 2.4 0.064 11.3 1.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Nucleoplasmin PF03066.10 ESS59087.1 - 0.68 9.4 7.9 0.06 12.8 2.2 1.7 2 0 0 2 2 2 0 Nucleoplasmin PBP1_TM PF14812.1 ESS59087.1 - 1.3 9.3 8.6 2 8.7 4.9 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.7 ESS59087.1 - 6.3 4.5 6.5 6 4.6 4.5 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.8 ESS59087.1 - 6.6 6.2 8.3 0.36 10.3 2.0 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region Mucin PF01456.12 ESS59088.1 - 1e-20 73.9 35.4 1e-20 73.9 24.5 3.0 2 1 0 2 2 2 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS59088.1 - 0.072 12.9 0.3 0.072 12.9 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4658) Nop14 PF04147.7 ESS59088.1 - 0.62 7.9 9.0 0.8 7.5 6.2 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.7 ESS59088.1 - 0.94 7.7 17.2 1.2 7.4 11.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RHSP PF07999.6 ESS59094.1 - 1.6e-97 326.9 0.1 2e-97 326.6 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_C PF11040.3 ESS59095.1 - 3.1e-38 129.5 2.6 4.1e-38 129.1 1.8 1.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS59096.1 - 1.5e-155 516.4 16.8 1.5e-155 516.4 11.7 2.2 2 1 1 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS59096.1 - 2.8e-40 136.5 15.3 2.8e-40 136.5 10.6 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Mucin PF01456.12 ESS59123.1 - 1.3e-25 89.8 40.4 2.3e-25 89.0 28.0 1.3 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF1675 PF07897.6 ESS59123.1 - 0.2 11.4 2.8 0.25 11.1 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Pex14_N PF04695.8 ESS59123.1 - 0.29 11.1 5.0 0.34 10.9 3.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Shisa PF13908.1 ESS59123.1 - 0.88 9.7 7.5 1 9.4 5.2 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PRCC PF10253.4 ESS59123.1 - 2.1 9.0 6.5 2.3 8.8 4.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting MGC-24 PF05283.6 ESS59123.1 - 4 7.1 22.8 4.8 6.9 15.8 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) MCPVI PF02993.9 ESS59123.1 - 4.5 7.3 6.3 4.7 7.2 4.3 1.0 1 0 0 1 1 1 0 Minor capsid protein VI DUF2360 PF10152.4 ESS59123.1 - 5.6 7.2 7.3 6.2 7.0 5.1 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) K167R PF08065.7 ESS59124.1 - 1.6 8.8 8.2 0.51 10.4 2.5 2.1 1 1 1 2 2 2 0 K167R (NUC007) repeat TFIIA PF03153.8 ESS59124.1 - 2.4 7.9 6.3 2.7 7.8 4.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mucin PF01456.12 ESS59126.1 - 0.00019 21.2 13.6 0.00057 19.6 9.4 1.8 1 1 0 1 1 1 1 Mucin-like glycoprotein ELH PF02323.10 ESS59126.1 - 0.45 9.6 2.0 0.69 9.0 1.4 1.2 1 0 0 1 1 1 0 Egg-laying hormone precursor BNR_3 PF13859.1 ESS59128.1 - 5.1e-124 413.3 6.0 1.1e-123 412.2 4.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS59128.1 - 3.7e-09 36.2 11.3 3.7e-09 36.2 7.8 2.3 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS59128.1 - 4.5e-05 23.7 0.4 0.00015 22.0 0.2 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS59152.1 - 5e-132 439.6 4.9 6.2e-132 439.3 2.4 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59152.1 - 1.2e-18 67.7 1.6 2.5e-18 66.8 0.4 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59152.1 - 5.6e-10 38.9 7.0 1.2e-09 37.8 4.9 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Permease PF02405.11 ESS59152.1 - 0.22 10.9 0.6 0.35 10.3 0.4 1.2 1 0 0 1 1 1 0 Permease FAM163 PF15069.1 ESS59153.1 - 0.019 15.5 0.8 0.023 15.2 0.6 1.2 1 0 0 1 1 1 0 FAM163 family ITI_HC_C PF06668.7 ESS59153.1 - 0.066 12.6 0.0 0.089 12.1 0.0 1.1 1 0 0 1 1 1 0 Inter-alpha-trypsin inhibitor heavy chain C-terminus DUF3681 PF12442.3 ESS59155.1 - 0.034 14.3 0.1 0.076 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) DUF4634 PF15465.1 ESS59156.1 - 0.034 14.3 1.0 0.1 12.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) W2 PF02020.13 ESS59156.1 - 0.1 12.5 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon RIC3 PF15361.1 ESS59157.1 - 0.31 11.2 1.9 0.35 11.0 1.3 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF2058 PF09831.4 ESS59157.1 - 2.9 7.7 7.5 3.6 7.4 5.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) BNR_3 PF13859.1 ESS59158.1 - 9.1e-131 435.5 5.3 1.8e-130 434.5 3.7 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59158.1 - 1.3e-17 64.5 0.1 3.3e-17 63.1 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59158.1 - 3.9e-11 42.6 10.3 1.1e-10 41.1 7.2 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M8 PF01457.11 ESS59160.1 - 3.8e-05 22.2 0.0 6e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Leishmanolysin Adaptin_N PF01602.15 ESS59314.1 - 0.0057 15.0 0.0 0.015 13.6 0.0 1.7 1 1 0 1 1 1 1 Adaptin N terminal region SGS PF05002.10 ESS59315.1 - 0.065 12.9 1.5 6.8 6.5 0.1 2.4 2 0 0 2 2 2 0 SGS domain DGF-1_5 PF11038.3 ESS59371.1 - 1.4e-163 542.7 17.5 1.4e-163 542.7 12.1 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS59371.1 - 4.9e-50 167.3 2.2 9.5e-50 166.4 1.5 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS59371.1 - 3.7e-33 113.7 14.8 8.4e-33 112.5 10.3 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS59372.1 - 5e-39 134.1 0.0 5.3e-39 134.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF2826 PF11442.3 ESS59383.1 - 2.9e-87 290.3 9.3 4.2e-87 289.8 6.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) BNR_3 PF13859.1 ESS59384.1 - 8.7e-129 429.0 6.3 8.7e-129 429.0 4.4 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59384.1 - 6.7e-09 36.1 2.9 6.7e-09 36.1 2.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS59384.1 - 0.00035 19.9 2.0 0.0042 16.4 0.1 2.5 2 1 0 2 2 2 1 BNR repeat-like domain BNR PF02012.15 ESS59384.1 - 0.02 14.6 0.4 6.1 7.1 0.0 4.0 2 0 0 2 2 2 0 BNR/Asp-box repeat DUF2147 PF09917.4 ESS59385.1 - 1 9.6 9.1 0.4 10.9 1.6 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) ACBP PF00887.14 ESS59393.1 - 1.2e-15 56.9 0.0 2.1e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein DUF3259 PF11652.3 ESS59393.1 - 0.059 13.5 0.6 0.1 12.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3259) DGF-1_4 PF11024.3 ESS59394.1 - 8.7e-32 109.3 18.0 1.4e-31 108.7 12.4 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS59396.1 - 5.7e-11 42.4 1.1 4.1e-05 23.3 0.7 3.7 2 1 0 2 2 2 1 Right handed beta helix region BNR_3 PF13859.1 ESS59401.1 - 5e-128 426.5 7.5 5e-128 426.5 5.2 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59401.1 - 7.8e-14 52.2 0.2 7.8e-14 52.2 0.1 2.4 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59401.1 - 3.5e-10 39.5 12.4 9.1e-10 38.2 8.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4416 PF14385.1 ESS59401.1 - 0.17 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) PAT1 PF09770.4 ESS59408.1 - 3.1 5.9 19.5 3.3 5.8 13.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.2 ESS59408.1 - 4.6 4.8 10.8 6.1 4.3 7.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BNR_3 PF13859.1 ESS59409.1 - 2.8e-129 430.6 6.4 5.1e-129 429.7 4.4 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59409.1 - 6.8e-20 71.8 2.4 2.4e-19 70.1 1.7 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59409.1 - 2.7e-11 43.1 10.0 7.6e-11 41.6 6.9 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS59455.1 - 8.2e-15 55.3 0.1 2.2e-14 53.9 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59455.1 - 1.1e-08 34.7 13.6 2.5e-08 33.6 9.5 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS59456.1 - 3.1e-69 233.4 5.1 4e-69 233.0 3.5 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS59456.1 - 0.073 12.3 0.0 0.097 11.9 0.0 1.3 1 0 0 1 1 1 0 BNR repeat-like domain zf-C2H2_4 PF13894.1 ESS59457.1 - 0.024 14.9 11.6 1.6 9.2 1.1 3.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS59457.1 - 0.37 11.1 10.4 1.5 9.2 1.2 3.0 2 0 0 2 2 2 0 Zinc-finger double domain zf-Di19 PF05605.7 ESS59457.1 - 0.59 10.3 7.6 2.6 8.2 5.3 2.1 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding RVT_1 PF00078.22 ESS59458.1 - 0.0078 15.5 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DGF-1_5 PF11038.3 ESS59487.1 - 4.3e-157 521.4 20.5 4.3e-157 521.4 14.2 3.4 4 0 0 4 4 4 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS59487.1 - 8.8e-39 131.7 17.2 8.8e-39 131.7 11.9 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS59487.1 - 4e-36 122.7 1.9 4.5e-36 122.5 0.2 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Atg14 PF10186.4 ESS59520.1 - 0.71 8.7 5.4 1.4 7.7 3.8 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IFT57 PF10498.4 ESS59520.1 - 0.79 8.3 3.7 1.2 7.7 2.6 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF4407 PF14362.1 ESS59520.1 - 2 7.3 12.4 0.51 9.2 6.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Phage_integrase PF00589.17 ESS59521.1 - 0.021 14.4 0.2 0.041 13.5 0.1 1.7 1 1 0 1 1 1 0 Phage integrase family DUF885 PF05960.6 ESS59523.1 - 0.0035 16.5 1.1 0.033 13.3 0.0 2.1 1 1 0 2 2 2 2 Bacterial protein of unknown function (DUF885) BNR_3 PF13859.1 ESS59525.1 - 3e-29 102.0 1.7 4.1e-29 101.6 0.2 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59525.1 - 1.7e-18 67.3 3.1 4.4e-18 65.9 2.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59525.1 - 1.4e-08 34.3 13.3 3e-08 33.3 9.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS59526.1 - 2.3e-93 312.6 3.9 3.1e-93 312.2 2.7 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS59526.1 - 0.0015 17.8 0.1 0.0021 17.3 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain EBP50_C-term PF09007.6 ESS59527.1 - 0.038 13.8 0.1 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 EBP50, C-terminal RVT_1 PF00078.22 ESS59527.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS59528.1 - 5.1e-07 30.0 0.0 8.3e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS59528.1 - 0.062 12.7 1.7 0.2 11.1 0.0 2.5 2 0 0 2 2 2 0 DAN domain zf-Di19 PF05605.7 ESS59528.1 - 0.66 10.1 7.3 3.1 7.9 5.0 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 ESS59528.1 - 1 9.5 7.9 4.7 7.4 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS59528.1 - 8.2 7.0 16.7 6 7.4 1.5 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger DUF912 PF06024.7 ESS59530.1 - 2.7 8.1 8.6 45 4.1 6.0 2.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Daxx PF03344.10 ESS59530.1 - 3.2 6.1 15.0 3.8 5.8 10.4 1.0 1 0 0 1 1 1 0 Daxx Family BNR_3 PF13859.1 ESS59531.1 - 4e-134 446.5 7.9 4e-134 446.5 5.5 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59531.1 - 8.9e-19 68.2 0.3 3.8e-18 66.1 0.2 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59531.1 - 1.8e-09 37.2 4.9 5.1e-09 35.8 3.4 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Phage_integrase PF00589.17 ESS59532.1 - 0.0056 16.3 0.2 0.0091 15.6 0.1 1.3 1 0 0 1 1 1 1 Phage integrase family DGF-1_5 PF11038.3 ESS59533.1 - 4.9e-161 534.3 17.4 4.9e-161 534.3 12.1 2.7 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS59533.1 - 2.2e-47 158.8 0.8 2.2e-47 158.8 0.6 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS59533.1 - 1.6e-35 121.3 17.9 3.9e-35 120.0 12.4 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Utp14 PF04615.8 ESS59882.1 - 8.7 4.3 31.9 12 3.9 22.1 1.1 1 0 0 1 1 1 0 Utp14 protein Sec1 PF00995.18 ESS59883.1 - 4.8e-17 61.8 0.0 5.9e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sec1 PF00995.18 ESS59884.1 - 1.4e-15 57.0 0.0 1.8e-15 56.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Mucin PF01456.12 ESS59885.1 - 7.7e-25 87.3 34.2 8.5e-25 87.2 23.7 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS59885.1 - 0.09 12.6 6.7 0.22 11.3 4.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) Pex14_N PF04695.8 ESS59885.1 - 0.22 11.5 2.5 0.23 11.5 1.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MGC-24 PF05283.6 ESS59885.1 - 0.59 9.9 22.1 0.62 9.8 15.3 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) TMEM154 PF15102.1 ESS59885.1 - 2.7 7.6 11.0 3.3 7.4 7.6 1.3 1 0 0 1 1 1 0 TMEM154 protein family Lamp PF01299.12 ESS59885.1 - 2.8 7.0 15.8 2.9 6.9 11.0 1.0 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Daxx PF03344.10 ESS59895.1 - 0.081 11.4 29.1 0.1 11.0 20.1 1.1 1 0 0 1 1 1 0 Daxx Family Utp14 PF04615.8 ESS59895.1 - 0.16 10.0 29.5 0.19 9.8 20.5 1.0 1 0 0 1 1 1 0 Utp14 protein DUF966 PF06136.8 ESS59895.1 - 1.6 8.0 16.2 2.2 7.6 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TFIIF_alpha PF05793.7 ESS59895.1 - 4.3 5.5 36.3 5.5 5.2 25.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4551 PF15087.1 ESS59895.1 - 6.9 4.8 11.9 8.5 4.6 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) BNR_3 PF13859.1 ESS59896.1 - 5.4e-125 416.5 4.9 5.4e-125 416.5 3.4 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59896.1 - 1.4e-19 70.8 2.2 1.7e-19 70.6 0.3 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Daxx PF03344.10 ESS59897.1 - 0.023 13.1 21.2 0.027 12.9 14.7 1.1 1 0 0 1 1 1 0 Daxx Family TFIIF_alpha PF05793.7 ESS59897.1 - 0.11 10.8 20.5 0.15 10.3 14.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Utp14 PF04615.8 ESS59897.1 - 0.13 10.3 22.3 0.16 10.1 15.4 1.1 1 0 0 1 1 1 0 Utp14 protein Menin PF05053.8 ESS59897.1 - 0.2 9.7 11.3 0.29 9.2 7.9 1.2 1 0 0 1 1 1 0 Menin BUD22 PF09073.5 ESS59897.1 - 2.1 7.3 23.8 2.6 7.0 16.5 1.2 1 0 0 1 1 1 0 BUD22 Peptidase_S64 PF08192.6 ESS59897.1 - 9.9 4.3 13.0 13 4.0 9.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 BNR_3 PF13859.1 ESS59923.1 - 7.2e-120 399.7 6.5 7.2e-120 399.7 4.5 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59923.1 - 2.1e-14 54.0 0.4 7.2e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59923.1 - 1.4e-10 40.8 8.7 3.1e-10 39.7 6.1 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS59924.1 - 1.2e-174 581.0 0.0 1.2e-174 581.0 0.0 1.3 2 0 0 2 2 2 1 Retrotransposon hot spot protein Mucin PF01456.12 ESS59926.1 - 4.1e-31 107.6 62.8 8.8e-30 103.3 43.5 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein Shisa PF13908.1 ESS59926.1 - 0.004 17.3 9.2 0.0052 16.9 6.4 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FAM163 PF15069.1 ESS59926.1 - 0.019 15.5 6.3 0.022 15.3 4.4 1.1 1 0 0 1 1 1 0 FAM163 family DUF1675 PF07897.6 ESS59926.1 - 0.11 12.3 4.6 0.14 12.0 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Pex14_N PF04695.8 ESS59926.1 - 0.52 10.3 5.7 0.61 10.1 4.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MCPVI PF02993.9 ESS59926.1 - 1.6 8.8 5.9 1.9 8.6 4.1 1.0 1 0 0 1 1 1 0 Minor capsid protein VI ETS_PEA3_N PF04621.8 ESS59926.1 - 2.6 7.1 6.6 3 6.9 4.6 1.0 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain PRCC PF10253.4 ESS59926.1 - 5.5 7.6 8.2 6.2 7.4 5.7 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF4366 PF14283.1 ESS59926.1 - 6 6.2 13.6 2.9 7.2 7.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Patched PF02460.13 ESS59927.1 - 0.24 9.2 2.1 0.27 9.1 1.4 1.0 1 0 0 1 1 1 0 Patched family RHSP PF07999.6 ESS59931.1 - 3e-120 401.7 0.0 5.2e-120 400.9 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS59931.1 - 0.067 13.3 0.0 1 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain BNR_3 PF13859.1 ESS59932.1 - 1.3e-52 178.7 0.0 1.7e-52 178.4 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS59934.1 - 1.2e-13 51.5 0.1 4.2e-13 49.8 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS59934.1 - 5.8e-07 29.2 9.3 5.8e-07 29.2 6.4 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS59934.1 - 0.026 14.5 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain MIP-T3 PF10243.4 ESS59936.1 - 7.5 4.8 38.3 11 4.2 26.5 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 TT_ORF2 PF02957.10 ESS60157.1 - 3 8.5 14.6 4.5 7.9 2.3 2.1 2 0 0 2 2 2 0 TT viral ORF2 Mucin PF01456.12 ESS60158.1 - 3.7e-23 81.8 46.5 7.4e-23 80.8 32.2 1.6 1 1 0 1 1 1 1 Mucin-like glycoprotein Sporozoite_P67 PF05642.6 ESS60158.1 - 5.4 4.7 12.5 6 4.5 8.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Herpes_UL32 PF06070.6 ESS60158.1 - 5.7 5.2 12.2 6.5 5.0 8.4 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 BNR_3 PF13859.1 ESS60189.1 - 3.3e-130 433.6 3.3 3.3e-130 433.6 2.3 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60190.1 - 3.3e-12 46.9 0.2 3.3e-12 46.9 0.2 1.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60190.1 - 4.3e-07 29.6 7.8 4.3e-07 29.6 5.4 2.6 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS60190.1 - 0.004 16.1 0.1 0.0062 15.5 0.1 1.2 1 0 0 1 1 1 1 Sialidase, N-terminal domain DUF4131 PF13567.1 ESS60190.1 - 4.8 6.5 5.5 0.32 10.3 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Tr-sialidase_C PF11052.3 ESS60191.1 - 3.9e-05 23.4 1.7 8.8e-05 22.2 1.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF1049 PF06305.6 ESS60193.1 - 0.94 8.9 3.4 0.4 10.1 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) DUF3720 PF12517.3 ESS60255.1 - 6.1e-14 52.5 10.8 6.1e-14 52.5 7.5 4.3 2 2 3 5 5 5 1 Protein of unknown function (DUF3720) CDC45 PF02724.9 ESS60255.1 - 2.1 6.2 8.4 3.1 5.7 5.9 1.4 1 0 0 1 1 1 0 CDC45-like protein Laminin_G_3 PF13385.1 ESS60257.1 - 1.7e-06 28.3 0.1 3.5e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60257.1 - 2.5e-06 26.8 0.0 5.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60259.1 - 1.2e-12 48.3 0.0 2.8e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60267.1 - 5.3e-128 426.4 3.3 1.2e-127 425.2 2.3 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60267.1 - 1.8e-11 44.5 0.5 4.6e-11 43.1 0.3 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Lysozyme_like PF13702.1 ESS60267.1 - 0.016 14.7 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Lysozyme-like Vac7 PF12751.2 ESS60267.1 - 0.035 12.9 1.1 0.053 12.3 0.7 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 DUF3720 PF12517.3 ESS60268.1 - 1.2e-10 41.9 12.7 1.2e-10 41.9 8.8 4.3 2 1 2 4 4 4 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS60270.1 - 1.2e-127 425.2 2.2 1.2e-127 425.2 1.5 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60270.1 - 4e-08 32.9 10.6 1.3e-07 31.3 7.4 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS60300.1 - 6e-162 537.3 18.4 6e-162 537.3 12.8 2.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60300.1 - 9.1e-47 156.8 0.6 9.1e-47 156.8 0.4 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS60300.1 - 1.2e-42 144.1 17.3 3.5e-42 142.6 12.0 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RVT_1 PF00078.22 ESS60301.1 - 3.4e-27 95.2 0.0 8.1e-27 93.9 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.6 ESS60302.1 - 1.1e-87 294.4 0.1 1.5e-87 294.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60302.1 - 0.034 14.2 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESS60302.1 - 0.09 12.3 0.1 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain BNR_3 PF13859.1 ESS60303.1 - 2.3e-22 79.4 0.0 4.3e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60303.1 - 3.6e-13 50.0 1.2 7.6e-13 48.9 0.3 2.0 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60303.1 - 0.0017 18.1 5.9 0.0038 17.0 4.1 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal AAA_2 PF07724.9 ESS60304.1 - 5e-53 179.5 0.1 5.8e-52 176.0 0.0 2.7 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESS60304.1 - 3.3e-29 101.7 0.0 3.8e-15 56.2 0.0 3.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 ESS60304.1 - 4.4e-20 71.3 3.8 8.5e-19 67.2 0.0 4.0 3 0 0 3 3 3 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.15 ESS60304.1 - 3.6e-17 62.0 1.0 2.2e-08 33.9 0.5 3.0 2 0 0 2 2 2 2 Clp amino terminal domain AAA_5 PF07728.9 ESS60304.1 - 8e-17 61.2 0.1 4.8e-12 45.7 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS60304.1 - 5.8e-13 49.2 4.4 0.00099 19.1 0.0 5.3 3 2 1 5 5 5 3 AAA ATPase domain AAA_22 PF13401.1 ESS60304.1 - 2.8e-11 43.6 0.7 0.00027 21.0 0.0 4.1 3 1 0 4 4 3 2 AAA domain Sigma54_activat PF00158.21 ESS60304.1 - 7.2e-10 38.5 0.0 5e-07 29.3 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.12 ESS60304.1 - 1.7e-08 34.0 0.0 0.0055 16.1 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.1 ESS60304.1 - 7.5e-08 32.3 0.0 0.0022 17.8 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ESS60304.1 - 1.1e-06 29.4 3.4 0.0046 17.7 0.0 3.9 2 2 1 3 3 3 2 AAA domain Zeta_toxin PF06414.7 ESS60304.1 - 2e-06 27.0 2.4 0.00066 18.8 0.0 4.4 6 0 0 6 6 6 1 Zeta toxin AAA_18 PF13238.1 ESS60304.1 - 3.6e-06 27.3 0.0 0.22 11.7 0.0 3.3 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 ESS60304.1 - 6e-06 26.0 0.0 0.034 13.8 0.0 3.5 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.1 ESS60304.1 - 7.6e-06 25.6 0.1 0.3 10.8 0.0 3.4 2 1 1 3 3 3 2 Part of AAA domain AAA_25 PF13481.1 ESS60304.1 - 1.7e-05 24.3 0.4 0.06 12.7 0.0 3.6 4 0 0 4 4 4 2 AAA domain RuvB_N PF05496.7 ESS60304.1 - 4.8e-05 22.5 0.3 0.076 12.0 0.0 3.8 4 0 0 4 4 4 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 ESS60304.1 - 7.7e-05 21.9 0.1 0.28 10.3 0.1 3.5 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 ESS60304.1 - 8.5e-05 21.5 0.0 0.2 10.5 0.0 3.0 2 1 0 2 2 2 2 Protein of unknown function (DUF815) RNA_helicase PF00910.17 ESS60304.1 - 0.00029 20.9 0.4 0.8 9.9 0.0 3.2 4 0 0 4 4 2 1 RNA helicase AAA_3 PF07726.6 ESS60304.1 - 0.00029 20.4 0.2 0.16 11.5 0.0 3.5 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ESS60304.1 - 0.0005 19.9 0.0 0.24 11.2 0.0 3.4 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESS60304.1 - 0.00064 19.5 5.2 0.46 10.1 0.0 4.5 3 3 1 4 4 3 1 Archaeal ATPase T2SE PF00437.15 ESS60304.1 - 0.0014 17.6 0.0 0.0063 15.4 0.0 2.0 2 1 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.1 ESS60304.1 - 0.0015 17.9 0.0 1.9 8.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.1 ESS60304.1 - 0.0018 18.2 0.1 2.4 8.0 0.0 3.5 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 ESS60304.1 - 0.0018 17.4 0.0 0.82 8.8 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESS60304.1 - 0.0026 18.0 4.5 1.3 9.2 0.0 4.1 4 1 0 4 4 3 1 ABC transporter MobB PF03205.9 ESS60304.1 - 0.003 17.2 0.0 1 9.0 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.10 ESS60304.1 - 0.0059 16.3 0.0 3.2 7.4 0.0 3.0 2 0 0 2 2 2 1 NTPase ResIII PF04851.10 ESS60304.1 - 0.0061 16.4 0.1 0.24 11.1 0.0 3.3 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DNA_pol3_delta2 PF13177.1 ESS60304.1 - 0.0066 16.1 0.0 0.22 11.1 0.0 3.1 3 1 0 3 3 2 1 DNA polymerase III, delta subunit AAA_10 PF12846.2 ESS60304.1 - 0.0067 15.8 3.3 0.82 9.0 0.0 4.0 4 1 1 5 5 5 1 AAA-like domain Miro PF08477.8 ESS60304.1 - 0.014 15.9 0.0 1.8 9.0 0.0 3.1 2 0 0 2 2 2 0 Miro-like protein AAA_24 PF13479.1 ESS60304.1 - 0.024 14.2 0.0 10 5.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 ESS60304.1 - 0.025 14.2 0.0 9.3 5.9 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MMR_HSR1 PF01926.18 ESS60304.1 - 0.045 13.7 0.0 2.1 8.3 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.1 ESS60304.1 - 0.19 12.0 25.6 1.7 8.9 0.0 4.6 4 1 1 5 5 3 0 AAA domain DUF87 PF01935.12 ESS60304.1 - 1.8 8.3 0.0 1.8 8.3 0.0 3.7 4 1 0 4 4 3 0 Domain of unknown function DUF87 AAA_13 PF13166.1 ESS60304.1 - 4.3 5.6 10.8 8.9 4.6 7.5 1.4 1 0 0 1 1 1 0 AAA domain COQ7 PF03232.8 ESS60307.1 - 0.085 12.3 1.6 8.2 5.8 0.0 2.4 2 1 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 Acyl-CoA_ox_N PF14749.1 ESS60307.1 - 0.12 12.7 4.5 1.7 8.9 0.1 3.2 3 0 0 3 3 3 0 Acyl-coenzyme A oxidase N-terminal BNR_3 PF13859.1 ESS60309.1 - 7.7e-68 228.8 1.8 7.7e-68 228.8 1.2 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60309.1 - 1.2e-11 45.0 0.1 1.4e-10 41.6 0.0 2.6 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS60309.1 - 7.9e-07 28.6 2.3 7.8e-06 25.3 0.4 2.4 2 0 0 2 2 2 1 BNR repeat-like domain BNR PF02012.15 ESS60309.1 - 0.00019 20.7 5.3 0.31 11.0 0.1 3.9 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_3 PF13859.1 ESS60311.1 - 2e-66 224.1 0.9 2e-66 224.1 0.6 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60311.1 - 4.2e-10 40.0 1.1 1.9e-09 37.9 0.0 2.7 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60311.1 - 9.1e-06 25.4 2.6 9.1e-06 25.4 1.8 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Suppressor_P21 PF11479.3 ESS60312.1 - 0.13 11.9 0.1 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA silencing suppressor P21 BNR_3 PF13859.1 ESS60316.1 - 1.8e-126 421.3 8.1 1.8e-126 421.3 5.6 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60316.1 - 5.9e-18 65.5 4.7 8.9e-18 65.0 2.3 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60316.1 - 1e-10 41.2 15.6 3.1e-10 39.7 10.8 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MORN PF02493.15 ESS60316.1 - 2.5 8.0 5.2 12 5.8 0.3 3.0 2 0 0 2 2 2 0 MORN repeat Daxx PF03344.10 ESS60320.1 - 4.2 5.7 15.2 5 5.4 10.5 1.1 1 0 0 1 1 1 0 Daxx Family RVT_1 PF00078.22 ESS60322.1 - 8.7e-10 38.3 0.0 1.4e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PS_pyruv_trans PF04230.8 ESS60322.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase Tr-sialidase_C PF11052.3 ESS60326.1 - 1.7e-10 40.5 12.1 3.8e-10 39.4 8.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60329.1 - 7.6e-67 225.5 2.7 1.2e-66 224.9 1.9 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60329.1 - 3.6e-08 33.7 5.6 3.6e-08 33.7 0.0 3.5 2 2 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Nop14 PF04147.7 ESS60329.1 - 0.071 11.0 2.7 0.1 10.4 1.8 1.1 1 0 0 1 1 1 0 Nop14-like family BNR PF02012.15 ESS60329.1 - 0.21 11.5 15.3 0.19 11.6 0.4 4.2 4 0 0 4 4 4 0 BNR/Asp-box repeat Nucleoplasmin PF03066.10 ESS60329.1 - 0.89 9.0 5.2 1.6 8.2 3.6 1.4 1 0 0 1 1 1 0 Nucleoplasmin DUF2457 PF10446.4 ESS60329.1 - 1.7 7.2 12.8 2.7 6.6 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) YL1 PF05764.8 ESS60329.1 - 8.2 5.9 5.8 13 5.3 4.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein BNR_3 PF13859.1 ESS60330.1 - 6.4e-26 91.1 0.4 1.1e-25 90.3 0.1 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60330.1 - 7.4e-13 49.0 0.1 3.4e-12 46.8 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60330.1 - 3.5e-10 39.5 6.4 7.2e-10 38.5 4.4 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS60330.1 - 1.4 9.0 4.0 0.63 10.1 0.2 2.7 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS60331.1 - 1.2e-28 100.1 0.7 2.8e-28 98.9 0.2 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Bd3614-deam PF14439.1 ESS60331.1 - 0.027 14.3 0.2 0.076 12.8 0.1 1.7 1 0 0 1 1 1 0 Bd3614-like deaminase BNR PF02012.15 ESS60331.1 - 0.091 12.6 0.6 0.091 12.6 0.4 2.7 2 0 0 2 2 2 0 BNR/Asp-box repeat Beta_helix PF13229.1 ESS60334.1 - 0.00021 21.1 5.6 0.0027 17.4 3.5 2.5 1 1 1 2 2 2 2 Right handed beta helix region DGF-1_5 PF11038.3 ESS60335.1 - 6.5e-163 540.5 17.2 6.5e-163 540.5 12.0 2.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60335.1 - 1.4e-45 153.1 1.6 5.1e-45 151.2 1.1 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS60335.1 - 1.7e-35 121.1 19.4 5e-35 119.7 13.4 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS60337.1 - 1e-16 60.9 0.0 1.8e-16 60.1 0.0 1.3 1 1 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60339.1 - 1.4e-09 37.6 12.4 2.7e-09 36.7 8.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS60339.1 - 0.0053 17.0 0.0 0.0053 17.0 0.0 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Neisseria_TspB PF05616.8 ESS60339.1 - 5.7 5.1 6.2 7.4 4.8 4.3 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein BNR_3 PF13859.1 ESS60340.1 - 1.3e-45 155.8 1.5 1.7e-45 155.4 1.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS60341.1 - 1.2e-38 132.8 1.0 1.5e-38 132.5 0.1 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS60344.1 - 4e-130 433.4 5.7 4e-130 433.4 3.9 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60344.1 - 4.2e-16 59.5 0.9 1e-15 58.2 0.6 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PAT1 PF09770.4 ESS60346.1 - 6.6 4.8 13.7 7 4.7 9.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_M8 PF01457.11 ESS60348.1 - 4.8e-69 233.0 13.4 6.5e-68 229.3 9.3 2.0 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS60348.1 - 1.1e-10 41.1 4.5 2e-10 40.3 3.1 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS60348.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Matrixin DUF3810 PF12725.2 ESS60348.1 - 0.15 10.9 0.0 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DUF3720 PF12517.3 ESS60352.1 - 2.6e-19 69.7 13.0 2.6e-19 69.7 9.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3720) RVT_1 PF00078.22 ESS60356.1 - 3.5e-16 59.2 0.1 4.6e-16 58.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MCLC PF05934.6 ESS60359.1 - 0.021 13.1 0.0 0.035 12.4 0.0 1.3 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DGF-1_5 PF11038.3 ESS60362.1 - 3.6e-161 534.8 19.8 6.1e-161 534.0 13.7 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS60362.1 - 1.2e-39 134.5 16.4 3.2e-39 133.1 11.4 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS60362.1 - 4.1e-36 122.7 2.5 9.2e-36 121.6 1.7 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF1129 PF06570.6 ESS60362.1 - 1.3 8.2 3.1 1.2 8.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) BNR_3 PF13859.1 ESS60363.1 - 2.5e-68 230.4 0.3 5.6e-68 229.2 0.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60363.1 - 4.8e-17 62.6 3.4 1.4e-16 61.0 2.4 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60363.1 - 8.3e-10 38.3 12.7 8.3e-10 38.3 8.8 2.4 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60364.1 - 5.7e-24 84.6 16.0 5.7e-24 84.6 11.1 3.8 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) FlbD PF06289.6 ESS60364.1 - 0.045 13.1 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 Flagellar protein (FlbD) BNR_3 PF13859.1 ESS60370.1 - 2.9e-134 447.0 5.6 4.1e-134 446.5 3.9 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60371.1 - 2.6e-11 43.1 10.6 4.5e-11 42.3 7.3 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS60371.1 - 7.4e-07 29.5 0.3 1.6e-06 28.4 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Ctr PF04145.10 ESS60372.1 - 1.5 8.8 5.3 0.87 9.6 0.0 2.2 2 1 0 2 2 2 0 Ctr copper transporter family Mucin PF01456.12 ESS60374.1 - 3e-33 114.6 40.4 1.2e-20 73.6 15.4 2.3 1 1 1 2 2 2 2 Mucin-like glycoprotein BNR_3 PF13859.1 ESS60376.1 - 1.9e-85 286.7 4.4 2.5e-85 286.3 3.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60379.1 - 0.00024 21.4 0.0 0.00029 21.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Vac7 PF12751.2 ESS60380.1 - 0.074 11.8 0.4 0.088 11.6 0.3 1.0 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 BNR_3 PF13859.1 ESS60381.1 - 7.6e-118 393.0 8.8 7.6e-118 393.0 6.1 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60381.1 - 1.5e-13 51.3 2.0 1.5e-13 51.3 1.4 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS60382.1 - 4e-35 121.2 0.0 6e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Claudin_2 PF13903.1 ESS60383.1 - 0.31 10.7 4.8 0.38 10.4 3.3 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4131 PF13567.1 ESS60383.1 - 0.35 10.2 4.8 0.41 10.0 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) BNR_3 PF13859.1 ESS60384.1 - 2.2e-130 434.2 2.1 2.2e-130 434.2 1.5 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60384.1 - 9.1e-18 64.9 1.3 2.5e-17 63.5 0.9 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60384.1 - 3.4e-09 36.3 8.8 8.7e-09 35.1 6.1 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS60384.1 - 0.0024 17.1 0.1 0.011 15.0 0.0 2.2 2 0 0 2 2 2 1 BNR repeat-like domain zf-C2H2_4 PF13894.1 ESS60387.1 - 0.8 10.1 3.9 15 6.1 1.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.22 ESS60389.1 - 2.8e-15 56.2 0.0 3.7e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESS60389.1 - 1.3e-09 37.6 0.0 3.1e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DGF-1_5 PF11038.3 ESS60390.1 - 8e-129 428.7 22.4 8e-129 428.7 15.5 2.2 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60390.1 - 6.5e-49 163.7 1.3 6.5e-49 163.7 0.9 2.4 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Beta_helix PF13229.1 ESS60390.1 - 0.00013 21.7 3.1 0.14 11.9 0.0 3.7 2 1 2 4 4 4 2 Right handed beta helix region TBD PF12845.2 ESS60393.1 - 0.068 12.7 0.6 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 TBD domain PhnH PF05845.7 ESS60394.1 - 0.13 11.7 0.3 0.29 10.6 0.1 1.8 1 1 1 2 2 2 0 Bacterial phosphonate metabolism protein (PhnH) zf-CCHC_6 PF15288.1 ESS60398.1 - 0.11 12.2 0.7 0.23 11.1 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle Tox-SGS PF15651.1 ESS60400.1 - 0.043 13.5 0.4 0.043 13.5 0.3 1.6 2 0 0 2 2 2 0 Salivary glad secreted protein domain toxin DNA_pol_E_B PF04042.11 ESS60400.1 - 0.1 11.8 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B BNR_3 PF13859.1 ESS60401.1 - 5.2e-67 226.1 1.0 6.9e-67 225.7 0.7 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS60401.1 - 0.015 14.9 0.7 0.19 11.6 0.1 3.3 2 0 0 2 2 2 0 BNR/Asp-box repeat Imp-YgjV PF10688.4 ESS60404.1 - 0.11 11.8 0.8 3 7.2 0.1 2.1 2 0 0 2 2 2 0 Bacterial inner membrane protein Abhydrolase_6 PF12697.2 ESS60407.1 - 8.4e-16 58.5 0.3 1e-15 58.2 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS60407.1 - 8.4e-08 32.0 0.1 4.2e-07 29.7 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESS60407.1 - 1.1e-06 28.4 0.2 1.5e-06 28.0 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESS60407.1 - 0.0057 16.2 0.0 1 8.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold PGAP1 PF07819.8 ESS60407.1 - 0.009 15.6 0.2 0.018 14.6 0.0 1.5 2 0 0 2 2 2 1 PGAP1-like protein Ser_hydrolase PF06821.8 ESS60407.1 - 0.07 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Thioesterase PF00975.15 ESS60407.1 - 0.11 12.7 0.4 0.16 12.2 0.2 1.7 1 1 0 1 1 1 0 Thioesterase domain IncA PF04156.9 ESS60408.1 - 0.023 14.3 0.5 0.033 13.8 0.4 1.2 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.6 ESS60408.1 - 0.11 11.0 0.9 0.16 10.5 0.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESS60408.1 - 0.76 8.6 7.6 1.1 8.1 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RVT_1 PF00078.22 ESS60411.1 - 0.06 12.6 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.6 ESS60413.1 - 5.4e-96 321.8 3.8 7.7e-96 321.3 0.0 2.1 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60413.1 - 0.12 12.5 0.0 19 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain DGF-1_5 PF11038.3 ESS60416.1 - 1.4e-164 546.0 16.7 1.4e-164 546.0 11.5 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS60416.1 - 3.1e-35 120.4 16.0 1.1e-34 118.5 11.1 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS60418.1 - 8.2e-130 432.3 3.7 8.2e-130 432.3 2.5 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60418.1 - 3e-18 66.5 0.1 7.5e-18 65.2 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60418.1 - 2.3e-09 36.9 10.0 2.3e-09 36.9 6.9 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal FAM72 PF14976.1 ESS60419.1 - 0.24 11.2 5.7 0.34 10.7 4.0 1.2 1 0 0 1 1 1 0 FAM72 protein RVT_1 PF00078.22 ESS60420.1 - 5.3e-28 97.8 0.0 6.7e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4343 PF14243.1 ESS60422.1 - 0.069 13.0 0.1 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4343) DUF3676 PF12429.3 ESS60423.1 - 4.1e-104 347.2 52.1 6e-104 346.6 36.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS60423.1 - 1.9e-82 276.8 0.0 1.9e-82 276.8 0.0 3.0 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60423.1 - 5.2e-09 35.8 3.5 5.2e-09 35.8 2.4 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60427.1 - 9.6e-135 448.5 5.3 1.6e-134 447.9 3.7 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60427.1 - 3.1e-18 66.5 0.2 1.2e-17 64.5 0.2 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60427.1 - 5.7e-09 35.6 10.8 5.7e-09 35.6 7.5 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60432.1 - 3.1e-128 427.2 9.7 3.1e-128 427.2 6.7 2.6 2 1 1 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60432.1 - 7.7e-16 58.7 0.4 7.7e-16 58.7 0.3 2.5 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60432.1 - 8.4e-09 35.1 13.4 2.6e-08 33.5 9.3 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60434.1 - 3.9e-21 75.5 19.3 6.5e-21 74.8 13.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3720) Corona_S2 PF01601.11 ESS60435.1 - 0.16 10.0 3.4 0.2 9.6 2.3 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF1623 PF07785.6 ESS60435.1 - 0.16 11.8 0.5 0.25 11.2 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) BNR_3 PF13859.1 ESS60436.1 - 2.2e-130 434.3 5.2 7.6e-130 432.4 4.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60436.1 - 8.2e-18 65.1 0.2 2.9e-17 63.3 0.2 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60436.1 - 3.6e-09 36.3 10.7 3.6e-09 36.3 7.4 2.5 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Nuc_deoxyrib_tr PF05014.10 ESS60437.1 - 3.2e-10 39.8 0.0 5.2e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase UPF0547 PF10571.4 ESS60437.1 - 0.16 11.6 2.3 0.17 11.5 0.7 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Mucin PF01456.12 ESS60438.1 - 3.4e-37 127.3 33.5 6.5e-37 126.4 23.2 1.5 1 1 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.7 ESS60438.1 - 0.014 13.1 8.8 0.018 12.8 6.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3591 PF12157.3 ESS60438.1 - 0.16 10.3 0.5 0.21 9.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3591) SSP160 PF06933.6 ESS60438.1 - 0.62 7.9 17.3 0.83 7.5 12.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TMEM154 PF15102.1 ESS60438.1 - 6.2 6.5 6.7 10 5.8 4.7 1.4 1 0 0 1 1 1 0 TMEM154 protein family Gp_dh_C PF02800.15 ESS60439.1 - 7.5e-44 148.9 0.0 1e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain RAMP4 PF06624.7 ESS60441.1 - 0.007 15.8 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 MIP-T3 PF10243.4 ESS60441.1 - 0.27 9.6 21.9 0.33 9.3 15.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 BNR_3 PF13859.1 ESS60442.1 - 1.4e-89 300.2 2.7 2.3e-89 299.5 1.9 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60442.1 - 8.5e-17 61.8 0.5 3.2e-16 59.9 0.3 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60442.1 - 2.6e-10 39.9 6.6 6.4e-10 38.7 4.6 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal ETRAMP PF09716.5 ESS60444.1 - 0.09 12.7 0.0 2 8.4 0.0 3.0 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) DUF4131 PF13567.1 ESS60444.1 - 0.13 11.6 0.8 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Utp14 PF04615.8 ESS60444.1 - 6.5 4.7 39.7 8.3 4.4 27.5 1.0 1 0 0 1 1 1 0 Utp14 protein HA PF03457.9 ESS60448.1 - 0.016 15.2 0.5 0.016 15.2 0.3 2.1 2 1 0 2 2 2 0 Helicase associated domain MAD PF05557.8 ESS60451.1 - 0.047 11.7 2.5 0.063 11.3 1.7 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein RVT_1 PF00078.22 ESS60452.1 - 1.7e-19 70.0 0.0 2.4e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS60452.1 - 0.026 14.3 0.5 0.15 11.9 0.1 2.4 3 0 0 3 3 3 0 EBP50, C-terminal DUF3676 PF12429.3 ESS60455.1 - 2.9e-105 350.9 51.3 4.3e-105 350.4 35.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS60455.1 - 2.4e-80 269.9 0.8 2.4e-80 269.9 0.5 2.4 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60455.1 - 1.4e-09 37.5 5.1 1.4e-09 37.5 3.5 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF241 PF03087.9 ESS60456.1 - 0.044 13.2 0.7 6.6 6.1 0.1 2.0 2 0 0 2 2 2 0 Arabidopsis protein of unknown function Myosin_tail_1 PF01576.14 ESS60460.1 - 0.0061 14.3 4.4 0.0082 13.9 3.0 1.0 1 0 0 1 1 1 1 Myosin tail DUF4407 PF14362.1 ESS60460.1 - 0.042 12.7 5.7 0.061 12.2 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.3 ESS60460.1 - 0.1 12.6 2.6 0.17 11.9 1.8 1.3 1 0 0 1 1 1 0 YlqD protein Spc7 PF08317.6 ESS60460.1 - 0.2 10.2 0.7 0.29 9.7 0.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.4 ESS60460.1 - 0.27 10.1 2.5 0.43 9.4 1.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Pterin_4a PF01329.14 ESS60463.1 - 0.015 15.0 0.1 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase Melibiase PF02065.13 ESS60463.1 - 0.017 13.8 0.0 0.02 13.5 0.0 1.1 1 0 0 1 1 1 0 Melibiase DGF-1_5 PF11038.3 ESS60464.1 - 1.9e-126 420.9 20.1 4.6e-126 419.6 13.9 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60464.1 - 1.2e-44 150.0 1.1 2.9e-44 148.8 0.7 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF3377 PF11857.3 ESS60467.1 - 0.022 14.3 0.6 0.022 14.3 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) 3HCDH_N PF02737.13 ESS60468.1 - 7.9e-50 169.0 3.9 1.5e-49 168.1 2.7 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH PF00378.15 ESS60468.1 - 4.1e-43 147.2 0.2 7.1e-43 146.4 0.1 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family 3HCDH PF00725.17 ESS60468.1 - 1e-38 131.6 0.1 2.1e-24 85.7 0.1 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 ESS60468.1 - 2.2e-06 27.6 0.5 7e-06 25.9 0.3 1.9 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESS60468.1 - 0.021 15.2 0.2 0.059 13.8 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 ESS60468.1 - 0.073 13.1 0.1 0.22 11.6 0.1 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glutaredoxin PF00462.19 ESS60469.1 - 0.00015 21.6 0.0 0.0004 20.3 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 ESS60469.1 - 0.00083 19.5 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESS60469.1 - 0.06 13.8 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RNase_H PF00075.19 ESS60470.1 - 0.00046 20.5 0.0 0.00068 19.9 0.0 1.2 1 0 0 1 1 1 1 RNase H EBP50_C-term PF09007.6 ESS60470.1 - 0.039 13.8 0.1 0.079 12.8 0.1 1.5 1 0 0 1 1 1 0 EBP50, C-terminal FAP PF07174.6 ESS60471.1 - 0.11 11.7 6.6 0.17 11.1 4.5 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Mucin PF01456.12 ESS60472.1 - 1.2e-29 102.9 70.4 4.6e-28 97.7 48.8 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS60472.1 - 0.016 15.7 7.2 0.019 15.5 5.0 1.1 1 0 0 1 1 1 0 FAM163 family Shisa PF13908.1 ESS60472.1 - 0.04 14.1 9.0 0.054 13.6 6.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS60472.1 - 0.086 13.1 1.5 0.092 13.0 1.1 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) LAT PF15234.1 ESS60472.1 - 0.14 11.5 7.3 0.18 11.2 5.1 1.1 1 0 0 1 1 1 0 Linker for activation of T-cells Pex14_N PF04695.8 ESS60472.1 - 0.68 9.9 6.3 0.84 9.6 4.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PRCC PF10253.4 ESS60472.1 - 2.8 8.6 7.4 3.3 8.3 5.1 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF1180 PF06679.7 ESS60472.1 - 7.7 6.3 15.2 3.8 7.3 3.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) TFIIA PF03153.8 ESS60473.1 - 7.4 6.3 7.0 8.3 6.1 4.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BNR_3 PF13859.1 ESS60475.1 - 1.4e-129 431.6 5.9 4.2e-129 430.0 4.1 1.9 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60475.1 - 6.8e-18 65.3 1.9 6.8e-18 65.3 1.3 2.5 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60475.1 - 3e-09 36.5 12.4 3e-09 36.5 8.6 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal CDC27 PF09507.5 ESS60476.1 - 0.23 10.6 12.6 0.33 10.1 8.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AMP-binding PF00501.23 ESS60479.1 - 2.6e-89 299.5 0.0 3.5e-89 299.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Pkinase PF00069.20 ESS60481.1 - 3.7e-53 180.3 0.0 5.5e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS60481.1 - 4.5e-28 98.0 0.0 6.9e-28 97.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESS60481.1 - 0.00026 20.3 0.0 0.00044 19.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESS60481.1 - 0.00085 19.1 0.0 0.23 11.1 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS60481.1 - 0.0052 15.8 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RVT_1 PF00078.22 ESS60482.1 - 0.00031 20.1 0.0 0.0005 19.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mucin PF01456.12 ESS60484.1 - 1.1e-30 106.2 54.3 5.8e-21 74.7 17.2 2.7 1 1 1 2 2 2 2 Mucin-like glycoprotein Phage_fiber_2 PF03406.8 ESS60486.1 - 0.061 12.9 1.2 0.17 11.5 0.8 1.8 1 0 0 1 1 1 0 Phage tail fibre repeat SAA PF00277.13 ESS60488.1 - 0.16 12.3 1.8 0.21 11.9 1.2 1.3 1 0 0 1 1 1 0 Serum amyloid A protein Dickkopf_N PF04706.7 ESS60488.1 - 0.17 12.0 0.5 0.17 12.0 0.3 2.2 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Suppressor_P21 PF11479.3 ESS60490.1 - 0.13 12.0 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA silencing suppressor P21 BNR_3 PF13859.1 ESS60491.1 - 6.3e-73 245.5 3.4 6.3e-73 245.5 2.3 3.2 2 1 0 2 2 2 1 BNR repeat-like domain DUF2826 PF11442.3 ESS60493.1 - 1.5e-89 297.7 8.2 2.4e-89 297.0 5.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) Exo_endo_phos_2 PF14529.1 ESS60494.1 - 1.9e-16 59.7 0.0 2.9e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS60494.1 - 0.0014 18.6 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CoA_transf_3 PF02515.12 ESS60495.1 - 0.076 12.2 0.1 0.076 12.2 0.0 1.1 1 0 0 1 1 1 0 CoA-transferase family III BNR_3 PF13859.1 ESS60496.1 - 1.1e-132 441.7 8.8 1.1e-132 441.7 6.1 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60496.1 - 1.4e-14 54.6 0.2 5.5e-14 52.6 0.1 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60496.1 - 2.3e-10 40.1 10.3 7.2e-10 38.5 7.1 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Invasin_D3 PF09134.5 ESS60496.1 - 0.032 14.1 0.1 0.71 9.7 0.0 2.7 2 0 0 2 2 2 0 Invasin, domain 3 SSI PF00720.12 ESS60496.1 - 0.05 13.5 0.0 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 Subtilisin inhibitor-like LAT PF15234.1 ESS60497.1 - 0.17 11.3 0.9 0.36 10.2 0.2 1.8 1 1 1 2 2 2 0 Linker for activation of T-cells ZU5 PF00791.15 ESS60498.1 - 0.11 12.2 0.2 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 ZU5 domain Mucin PF01456.12 ESS60499.1 - 8.7e-32 109.8 63.5 2.2e-30 105.3 44.0 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein Shisa PF13908.1 ESS60499.1 - 0.013 15.6 8.5 0.018 15.2 5.9 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator FAM163 PF15069.1 ESS60499.1 - 0.036 14.6 7.0 0.041 14.4 4.8 1.1 1 0 0 1 1 1 0 FAM163 family Pex14_N PF04695.8 ESS60499.1 - 0.15 12.0 6.1 0.18 11.8 4.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1675 PF07897.6 ESS60499.1 - 0.2 11.5 4.9 0.24 11.2 3.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DUF2360 PF10152.4 ESS60499.1 - 0.21 11.8 3.5 0.24 11.6 2.5 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) MCPVI PF02993.9 ESS60499.1 - 0.64 10.1 5.1 0.75 9.9 3.5 1.1 1 0 0 1 1 1 0 Minor capsid protein VI LAT PF15234.1 ESS60499.1 - 0.8 9.1 7.8 1.1 8.6 5.4 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells PRCC PF10253.4 ESS60499.1 - 1.8 9.2 8.2 2.1 9.0 5.7 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF3484 PF11983.3 ESS60499.1 - 2.6 8.9 5.1 4.3 8.2 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) DUF1180 PF06679.7 ESS60499.1 - 2.7 7.8 12.7 8.6 6.2 8.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4366 PF14283.1 ESS60499.1 - 3.4 7.0 14.2 2.4 7.5 8.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF3530 PF12048.3 ESS60499.1 - 8.6 5.2 14.9 34 3.2 10.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) YfhO PF09586.5 ESS60500.1 - 1.6 6.6 7.8 1.7 6.5 5.4 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4131 PF13567.1 ESS60500.1 - 1.9 7.8 9.7 2.1 7.7 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) RHSP PF07999.6 ESS60502.1 - 3e-77 260.0 0.8 3e-77 260.0 0.5 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS60502.1 - 0.0091 15.4 0.2 0.88 8.9 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain AAA_28 PF13521.1 ESS60502.1 - 0.01 15.8 0.5 0.58 10.1 0.5 2.7 2 0 0 2 2 2 0 AAA domain DUF4152 PF13680.1 ESS60502.1 - 0.042 12.8 0.0 0.072 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4152) AAA_18 PF13238.1 ESS60502.1 - 0.073 13.3 0.1 6.4 7.0 0.0 2.9 2 1 0 2 2 2 0 AAA domain BNR_3 PF13859.1 ESS60503.1 - 4.9e-61 206.4 0.0 6.6e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS60503.1 - 1.2e-05 24.7 0.6 0.00052 19.3 0.3 2.3 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS60503.1 - 0.00015 21.0 3.0 0.19 11.6 0.1 3.2 2 0 0 2 2 2 2 BNR/Asp-box repeat Zip PF02535.17 ESS60504.1 - 0.19 10.7 3.7 0.26 10.2 2.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter hEGF PF12661.2 ESS60507.1 - 0.22 11.6 7.8 0.14 12.3 1.0 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF Peptidase_M8 PF01457.11 ESS60510.1 - 2.3e-12 46.0 0.0 2.7e-12 45.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin SDH_alpha PF03313.10 ESS60511.1 - 0.0028 16.7 0.1 0.003 16.6 0.1 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain BNR_3 PF13859.1 ESS60512.1 - 1.9e-30 106.0 0.3 1.1e-29 103.5 0.1 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60512.1 - 1e-15 58.2 0.5 2.3e-15 57.1 0.4 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60512.1 - 2.8e-09 36.6 12.3 3.1e-09 36.5 7.6 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS60512.1 - 0.08 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Sialidase, N-terminal domain BNR_3 PF13859.1 ESS60513.1 - 2.3e-88 296.2 5.2 2.6e-88 296.0 3.6 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS60513.1 - 0.0076 15.5 0.2 0.015 14.5 0.1 1.6 1 1 0 1 1 1 1 BNR repeat-like domain RVT_1 PF00078.22 ESS60515.1 - 2.4e-12 46.6 0.1 3.2e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DGF-1_5 PF11038.3 ESS60516.1 - 3e-76 256.2 15.0 3e-76 256.2 10.4 1.7 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60516.1 - 9.5e-48 160.0 2.0 1.8e-47 159.1 1.4 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SR-25 PF10500.4 ESS60519.1 - 0.021 14.2 6.7 0.027 13.9 4.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ALMS_motif PF15309.1 ESS60519.1 - 0.086 12.6 8.7 0.11 12.3 6.0 1.1 1 0 0 1 1 1 0 ALMS motif Med25_NR-box PF11244.3 ESS60519.1 - 1.4 9.4 6.5 2 8.9 4.5 1.4 1 1 0 1 1 1 0 Mediator complex subunit 25 C-terminal NR box-containing Mif2_N PF15624.1 ESS60519.1 - 2.1 8.9 5.4 2.6 8.6 3.8 1.1 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal TAF1D PF15333.1 ESS60519.1 - 4.3 7.0 11.1 5.6 6.6 7.7 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D BRF1 PF07741.8 ESS60519.1 - 9.5 6.5 8.1 4.1 7.6 2.1 2.0 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Laminin_G_3 PF13385.1 ESS60520.1 - 6.4e-10 39.4 0.0 1e-09 38.8 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60520.1 - 6.4e-07 29.1 8.4 1.2e-06 28.2 5.8 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60521.1 - 5.3e-19 68.4 0.0 7.4e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS60522.1 - 0.069 12.9 3.1 1 9.1 0.6 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS60523.1 - 1.9e-23 83.0 0.0 3e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60523.1 - 1.6e-07 31.7 0.0 3.3e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60524.1 - 5.9e-94 314.6 3.0 5.9e-94 314.6 2.1 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60524.1 - 1.2e-16 61.3 2.3 1.2e-16 61.3 1.6 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60524.1 - 3.1e-11 42.9 11.3 7.4e-11 41.7 7.8 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS60529.1 - 5.8e-30 103.9 49.5 4.9e-23 81.4 18.5 2.0 1 1 1 2 2 2 2 Mucin-like glycoprotein SSP160 PF06933.6 ESS60529.1 - 0.0048 14.9 15.5 0.005 14.9 10.7 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 FAM163 PF15069.1 ESS60529.1 - 0.012 16.2 2.6 0.013 16.0 1.8 1.1 1 0 0 1 1 1 0 FAM163 family Shisa PF13908.1 ESS60529.1 - 0.014 15.5 3.4 0.014 15.5 2.3 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF3530 PF12048.3 ESS60529.1 - 0.017 14.1 2.1 0.021 13.8 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) LAT PF15234.1 ESS60529.1 - 0.059 12.8 6.5 0.076 12.4 4.5 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells DUF1180 PF06679.7 ESS60529.1 - 1.8 8.4 8.6 2.3 8.0 5.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4366 PF14283.1 ESS60529.1 - 5.1 6.4 9.2 4.8 6.5 5.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) TMEM154 PF15102.1 ESS60529.1 - 5.1 6.7 7.9 6.6 6.4 5.5 1.3 1 0 0 1 1 1 0 TMEM154 protein family Tir_receptor_C PF07489.6 ESS60529.1 - 5.7 6.6 10.0 6.7 6.4 7.0 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Mucin PF01456.12 ESS60531.1 - 4.2e-30 104.4 65.1 4.1e-28 97.9 45.1 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein Shisa PF13908.1 ESS60531.1 - 0.0073 16.4 7.9 0.0087 16.2 5.5 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS60531.1 - 0.028 14.7 1.4 0.031 14.5 1.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF1675 PF07897.6 ESS60531.1 - 0.057 13.2 3.7 0.07 12.9 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) FAM163 PF15069.1 ESS60531.1 - 0.11 13.0 6.3 0.13 12.8 4.4 1.1 1 0 0 1 1 1 0 FAM163 family Pex14_N PF04695.8 ESS60531.1 - 0.3 11.1 5.8 0.37 10.8 4.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PRCC PF10253.4 ESS60531.1 - 1.6 9.3 6.8 1.9 9.1 4.7 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF1180 PF06679.7 ESS60531.1 - 4.4 7.1 12.9 14 5.5 8.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Dicty_REP PF05086.7 ESS60531.1 - 7.4 4.1 13.0 8.6 3.9 9.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DGF-1_5 PF11038.3 ESS60536.1 - 4.4e-163 541.1 19.3 1.8e-162 539.0 13.4 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS60536.1 - 5.8e-27 93.8 11.9 3.5e-26 91.3 8.3 2.4 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS60536.1 - 1e-23 82.9 1.4 1e-23 82.9 1.0 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SID-1_RNA_chan PF13965.1 ESS60536.1 - 1.5 6.8 3.4 2.3 6.2 2.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BNR_3 PF13859.1 ESS60542.1 - 5.5e-06 25.6 0.1 7.2e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS60543.1 - 1.2e-54 185.5 0.1 1.5e-54 185.1 0.1 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS60543.1 - 2.2e-06 27.1 0.1 2.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS60543.1 - 0.00089 18.7 3.8 0.3 11.0 0.2 2.9 2 0 0 2 2 2 2 BNR/Asp-box repeat Laminin_G_3 PF13385.1 ESS60544.1 - 4.1e-10 40.1 0.0 4.7e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60544.1 - 0.0014 18.4 4.3 0.0028 17.4 3.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Pertus-S4-tox PF09275.5 ESS60544.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Pertussis toxin S4 subunit DUF1184 PF06683.6 ESS60545.1 - 0.035 13.7 0.1 0.04 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1184) BNR_3 PF13859.1 ESS60546.1 - 1.4e-68 231.2 1.9 2.5e-68 230.4 1.3 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60546.1 - 2.1e-08 34.5 4.3 2.3e-07 31.1 0.1 2.9 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF3676 PF12429.3 ESS60547.1 - 4.4e-106 353.6 42.8 7.1e-106 352.9 29.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS60547.1 - 8.9e-10 38.2 2.7 1.6e-09 37.4 1.9 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS60550.1 - 7.1e-63 212.7 0.0 9.9e-63 212.2 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS60551.1 - 4.1e-37 127.8 0.5 8e-36 123.5 0.0 2.0 2 0 0 2 2 2 2 Retrotransposon hot spot protein UPF0239 PF06783.6 ESS60552.1 - 0.28 11.1 3.9 0.9 9.4 2.7 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0239) BNR_3 PF13859.1 ESS60553.1 - 5.2e-132 439.6 9.1 1e-131 438.6 4.5 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60553.1 - 4.2e-17 62.8 0.6 1.5e-16 61.0 0.4 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60553.1 - 1.3e-10 40.9 8.7 3.7e-10 39.4 6.1 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60555.1 - 8.3e-22 77.7 10.6 8.3e-22 77.7 7.4 3.9 1 1 2 4 4 4 1 Protein of unknown function (DUF3720) Mem_trans PF03547.13 ESS60555.1 - 0.011 14.0 0.7 0.013 13.8 0.5 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF3676 PF12429.3 ESS60556.1 - 4.7e-107 356.8 40.4 7.2e-107 356.2 28.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS60556.1 - 1.4e-83 280.4 0.1 1.4e-83 280.4 0.1 2.0 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60556.1 - 2.6e-10 40.7 3.9 5.7e-10 39.6 1.5 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60556.1 - 2e-07 30.7 3.4 2e-07 30.7 2.3 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60557.1 - 1.2e-05 24.5 0.0 1.7e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS60558.1 - 5e-50 170.3 0.1 9.7e-50 169.3 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60558.1 - 5e-12 46.3 0.6 1.7e-11 44.6 0.0 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60558.1 - 3.5e-07 29.9 8.2 8e-07 28.8 5.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS60558.1 - 0.0019 17.5 0.3 0.0045 16.3 0.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain BNR PF02012.15 ESS60558.1 - 0.0094 15.6 10.7 0.12 12.2 0.3 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat GCV_T PF01571.16 ESS60558.1 - 0.038 13.3 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain BNR_3 PF13859.1 ESS60559.1 - 1.2e-66 224.8 0.3 1.9e-66 224.2 0.2 1.2 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS60560.1 - 1.2e-121 406.4 0.9 1.3e-121 406.2 0.1 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60560.1 - 0.03 14.4 0.2 3.1 7.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain Nucleoplasmin PF03066.10 ESS60560.1 - 0.25 10.8 6.3 0.5 9.8 4.3 1.4 1 0 0 1 1 1 0 Nucleoplasmin Myc_N PF01056.13 ESS60560.1 - 0.58 9.2 6.3 1.2 8.2 4.4 1.4 1 0 0 1 1 1 0 Myc amino-terminal region RXT2_N PF08595.6 ESS60560.1 - 4.1 7.2 7.2 0.24 11.1 1.3 1.6 2 0 0 2 2 2 0 RXT2-like, N-terminal Galactosyl_T PF01762.16 ESS60561.1 - 2.3e-08 33.8 0.0 0.0001 21.9 0.0 2.1 2 0 0 2 2 2 2 Galactosyltransferase Ribosomal_L34e PF01199.13 ESS60561.1 - 0.015 15.5 0.0 0.035 14.3 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L34e Pkinase PF00069.20 ESS60565.1 - 3.5e-30 105.0 0.0 4.4e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS60565.1 - 2.3e-09 36.6 0.0 3.3e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS60565.1 - 0.0079 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS60565.1 - 0.097 11.7 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IncA PF04156.9 ESS60566.1 - 0.014 14.9 7.0 0.014 14.9 4.9 4.6 1 1 3 4 4 3 0 IncA protein Reo_sigmaC PF04582.7 ESS60566.1 - 0.033 13.3 7.8 0.19 10.8 0.8 3.0 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Arm PF00514.18 ESS60566.1 - 0.054 13.3 0.2 0.24 11.2 0.0 2.2 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat BCDHK_Adom3 PF10436.4 ESS60566.1 - 0.059 12.8 0.3 0.15 11.5 0.2 1.6 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Filament PF00038.16 ESS60566.1 - 0.094 12.1 41.1 0.031 13.7 21.9 2.1 1 1 1 2 2 2 0 Intermediate filament protein Spc7 PF08317.6 ESS60566.1 - 0.1 11.2 36.3 0.027 13.1 3.0 3.2 1 1 2 3 3 2 0 Spc7 kinetochore protein DUF2450 PF10475.4 ESS60566.1 - 0.25 10.2 10.9 0.16 10.8 6.1 1.7 1 1 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) LMBR1 PF04791.11 ESS60566.1 - 0.46 9.0 2.4 0.52 8.8 0.5 1.8 1 1 1 2 2 2 0 LMBR1-like membrane protein Atg14 PF10186.4 ESS60566.1 - 0.63 8.9 35.6 0.24 10.3 1.2 2.9 2 1 1 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 RTBV_P46 PF06216.6 ESS60566.1 - 0.93 8.2 12.7 0.32 9.8 1.1 2.8 1 1 2 3 3 3 0 Rice tungro bacilliform virus P46 protein Fib_alpha PF08702.5 ESS60566.1 - 1 9.5 14.7 0.28 11.3 0.8 3.7 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF1284 PF06935.6 ESS60566.1 - 1.5 9.0 4.6 0.65 10.2 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1284) USP8_interact PF08941.5 ESS60566.1 - 2.2 7.5 7.1 2.2 7.5 1.2 2.8 2 1 1 3 3 3 0 USP8 interacting ATG16 PF08614.6 ESS60566.1 - 2.7 7.7 40.4 0.35 10.6 10.9 3.5 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF948 PF06103.6 ESS60566.1 - 5.8 6.8 8.9 8.9 6.2 0.1 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF310 PF03750.8 ESS60566.1 - 7.8 6.7 9.1 14 5.9 0.0 3.7 2 2 0 3 3 3 0 Protein of unknown function (DUF310) DUF1510 PF07423.6 ESS60567.1 - 0.0008 18.8 1.7 0.00098 18.5 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Herpes_gE PF02480.11 ESS60567.1 - 0.087 11.0 0.0 0.13 10.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Daxx PF03344.10 ESS60567.1 - 0.41 9.0 9.3 0.54 8.6 6.4 1.1 1 0 0 1 1 1 0 Daxx Family Enterotoxin_HS1 PF08090.6 ESS60567.1 - 0.64 9.8 3.5 1.8 8.3 2.4 1.8 1 0 0 1 1 1 0 Heat stable E.coli enterotoxin 1 Tim54 PF11711.3 ESS60567.1 - 0.68 8.4 4.2 0.95 7.9 2.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Menin PF05053.8 ESS60567.1 - 0.96 7.5 4.2 1.2 7.1 2.9 1.1 1 0 0 1 1 1 0 Menin FAM176 PF14851.1 ESS60567.1 - 1.2 8.8 6.2 2.2 7.9 4.3 1.4 1 0 0 1 1 1 0 FAM176 family Sigma70_ner PF04546.8 ESS60567.1 - 2.9 7.4 10.8 4 6.9 7.5 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 ESS60567.1 - 3.5 7.1 16.3 5.3 6.5 11.3 1.2 1 0 0 1 1 1 0 Nucleoplasmin Nop14 PF04147.7 ESS60567.1 - 3.6 5.3 14.7 4.7 5.0 10.2 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 ESS60567.1 - 4.4 5.9 13.8 6.1 5.4 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Myc_N PF01056.13 ESS60567.1 - 6.3 5.8 8.8 9.5 5.2 6.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PBP1_TM PF14812.1 ESS60567.1 - 6.9 7.0 10.7 11 6.3 7.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.5 ESS60567.1 - 7 6.9 17.2 13 6.0 11.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_M8 PF01457.11 ESS60569.1 - 1.1e-43 149.3 0.1 1.4e-43 149.0 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Astacin PF01400.19 ESS60569.1 - 0.07 12.5 0.1 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) DUF1025 PF06262.6 ESS60569.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Possibl zinc metallo-peptidase Peptidase_M10 PF00413.19 ESS60569.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Matrixin Reprolysin_5 PF13688.1 ESS60569.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF3810 PF12725.2 ESS60569.1 - 0.15 10.9 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) BNR_3 PF13859.1 ESS60570.1 - 8e-133 442.2 7.9 8e-133 442.2 5.5 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60570.1 - 3.7e-17 63.0 0.8 1.3e-16 61.2 0.6 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60570.1 - 2.3e-08 33.7 9.9 2.3e-08 33.7 6.9 2.8 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS60571.1 - 6.8e-96 321.5 0.1 8.7e-96 321.1 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60571.1 - 0.024 14.7 0.0 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain SUN PF03856.8 ESS60571.1 - 0.063 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Beta-glucosidase (SUN family) BNR_3 PF13859.1 ESS60577.1 - 1.1e-20 73.9 0.7 2.3e-20 72.9 0.0 1.8 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60577.1 - 0.00031 21.0 0.9 0.00068 19.9 0.0 2.0 3 1 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60579.1 - 6e-128 426.2 8.1 1e-127 425.4 5.6 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60579.1 - 4.6e-05 23.7 0.0 0.0087 16.3 0.0 2.9 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60579.1 - 0.00042 20.1 8.9 0.00042 20.1 6.1 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_C2 PF00648.16 ESS60579.1 - 0.099 11.6 0.2 0.18 10.7 0.2 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease DGF-1_5 PF11038.3 ESS60580.1 - 1.2e-112 375.6 8.8 1.2e-112 375.6 6.1 2.9 4 1 1 5 5 5 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS60580.1 - 2.8e-38 130.1 15.4 8.1e-38 128.6 10.7 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 dsrm PF00035.20 ESS60581.1 - 1.6 9.3 4.5 1.5 9.4 2.0 1.8 2 1 0 2 2 2 0 Double-stranded RNA binding motif Herpes_LMP2 PF07415.6 ESS60584.1 - 0.038 12.5 0.1 0.04 12.5 0.1 1.0 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Oxidored_q3 PF00499.15 ESS60585.1 - 0.49 10.1 13.3 0.56 9.9 9.2 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Laminin_G_3 PF13385.1 ESS60587.1 - 1.3e-17 64.5 0.3 3.1e-17 63.2 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60587.1 - 7.2e-11 41.7 8.7 1.7e-10 40.5 6.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS60587.1 - 0.0077 16.2 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Laminin G domain DUF3720 PF12517.3 ESS60588.1 - 1.5e-25 89.7 14.0 1.5e-25 89.7 9.7 4.0 2 1 2 4 4 4 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS60589.1 - 1.4e-131 438.2 3.2 2.2e-131 437.5 2.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60589.1 - 1e-08 35.5 0.2 3.5e-08 33.8 0.1 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60592.1 - 9.5e-131 435.4 3.3 1.8e-130 434.5 2.3 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60592.1 - 2.6e-16 60.2 3.1 2.6e-16 60.2 2.1 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60592.1 - 3.6e-07 29.9 10.9 8.4e-07 28.7 7.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60596.1 - 5.9e-76 255.4 1.6 1.4e-75 254.2 1.1 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60596.1 - 1.2e-17 64.5 1.0 2.6e-17 63.5 0.7 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60596.1 - 1.2e-09 37.8 7.3 1.2e-09 37.8 5.0 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS60597.1 - 8.4e-05 22.3 1.9 8.4e-05 22.3 1.3 3.2 2 1 0 2 2 2 1 Mucin-like glycoprotein Shisa PF13908.1 ESS60597.1 - 0.037 14.2 1.0 0.037 14.2 0.7 2.8 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator DNA_pol_viral_C PF00336.13 ESS60598.1 - 0.0025 17.1 0.0 0.0061 15.8 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase (viral) C-terminal domain Phage_integrase PF00589.17 ESS60599.1 - 0.00042 20.0 0.2 0.00063 19.4 0.2 1.5 1 1 0 1 1 1 1 Phage integrase family RHSP PF07999.6 ESS60600.1 - 2.8e-81 273.3 0.0 5.2e-81 272.4 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS60603.1 - 5.1e-66 222.8 0.2 7.9e-66 222.2 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60603.1 - 2e-11 44.3 0.2 9.5e-11 42.1 0.0 2.3 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS60603.1 - 0.0003 20.1 0.2 0.0044 16.3 0.0 2.6 2 1 1 3 3 3 2 BNR repeat-like domain BNR PF02012.15 ESS60603.1 - 0.00083 18.8 3.5 0.95 9.5 0.2 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat RHSP PF07999.6 ESS60604.1 - 1.2e-90 304.2 0.0 1.7e-90 303.7 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF2626 PF11117.3 ESS60607.1 - 0.093 13.1 0.2 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2626) BNR_3 PF13859.1 ESS60608.1 - 8.1e-63 212.3 1.3 1.5e-62 211.5 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60608.1 - 4.9e-16 59.3 2.8 4.9e-16 59.3 1.9 1.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60608.1 - 3e-08 33.3 10.6 6.7e-08 32.2 7.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60609.1 - 1.3e-27 96.3 13.2 1.3e-27 96.3 9.1 4.0 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) Daxx PF03344.10 ESS60611.1 - 0.011 14.2 24.0 0.014 13.9 16.6 1.1 1 0 0 1 1 1 0 Daxx Family TFIIF_alpha PF05793.7 ESS60611.1 - 0.59 8.4 26.6 0.79 8.0 18.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF966 PF06136.8 ESS60611.1 - 0.87 8.9 14.3 1.4 8.3 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) MIP-T3 PF10243.4 ESS60611.1 - 2.7 6.3 33.4 3.3 6.0 23.1 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Mucin PF01456.12 ESS60612.1 - 6.9e-46 155.5 29.7 8.8e-46 155.2 20.6 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4366 PF14283.1 ESS60612.1 - 0.019 14.3 0.4 0.019 14.3 0.3 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4569 PF15133.1 ESS60612.1 - 0.024 14.0 3.0 0.03 13.7 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) TRAP_alpha PF03896.11 ESS60612.1 - 0.08 11.9 0.8 0.11 11.5 0.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Dicty_REP PF05086.7 ESS60612.1 - 0.16 9.7 10.2 0.19 9.4 7.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF605 PF04652.11 ESS60612.1 - 0.4 10.0 11.0 0.45 9.8 7.6 1.0 1 0 0 1 1 1 0 Vta1 like DUF1675 PF07897.6 ESS60612.1 - 0.54 10.0 8.3 0.64 9.8 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Herpes_LMP1 PF05297.6 ESS60612.1 - 0.74 8.6 2.9 0.93 8.3 2.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Hamartin PF04388.7 ESS60616.1 - 0.16 10.5 13.2 0.22 10.1 9.1 1.1 1 0 0 1 1 1 0 Hamartin protein Daxx PF03344.10 ESS60616.1 - 0.22 9.9 25.7 0.28 9.6 17.8 1.2 1 0 0 1 1 1 0 Daxx Family MIP-T3 PF10243.4 ESS60616.1 - 3.5 5.9 34.9 4.9 5.5 24.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ycf1 PF05758.7 ESS60616.1 - 3.6 5.1 9.7 3.9 5.0 6.7 1.1 1 0 0 1 1 1 0 Ycf1 CDC45 PF02724.9 ESS60616.1 - 9.1 4.1 10.8 11 3.8 7.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Laminin_G_3 PF13385.1 ESS60623.1 - 3.6e-17 63.0 0.9 5.1e-17 62.5 0.6 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60623.1 - 1.8e-09 37.2 10.8 3.5e-09 36.3 7.5 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60624.1 - 5e-60 203.1 2.5 7.5e-60 202.5 1.7 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF2909 PF11137.3 ESS60624.1 - 0.082 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) RNase_H PF00075.19 ESS60626.1 - 1.2e-08 35.3 0.0 2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_jaz PF12171.3 ESS60626.1 - 0.11 12.6 3.7 4.9 7.4 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DAN PF03045.10 ESS60626.1 - 0.15 11.5 0.0 0.15 11.5 0.0 2.7 4 0 0 4 4 4 0 DAN domain zf-H2C2_2 PF13465.1 ESS60626.1 - 6.9 7.1 11.8 1.6 9.1 1.2 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESS60626.1 - 8 7.0 19.7 1.1 9.7 1.6 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type RNase_H PF00075.19 ESS60628.1 - 0.0013 19.0 0.0 0.0015 18.8 0.0 1.1 1 0 0 1 1 1 1 RNase H Laminin_G_3 PF13385.1 ESS60630.1 - 4.2e-06 27.0 0.1 5.1e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.18 ESS60630.1 - 0.035 14.1 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain GAGA_bind PF06217.7 ESS60632.1 - 3.7 7.4 17.9 4.7 7.0 12.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Pacs-1 PF10254.4 ESS60632.1 - 4.6 5.7 13.4 5.3 5.5 9.3 1.1 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein DDHD PF02862.12 ESS60632.1 - 6 6.5 9.0 6.6 6.4 6.2 1.2 1 0 0 1 1 1 0 DDHD domain Laminin_G_3 PF13385.1 ESS60633.1 - 6.1e-17 62.3 1.1 6.1e-17 62.3 0.8 1.6 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60633.1 - 1.2e-09 37.8 14.1 2.6e-09 36.7 9.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60635.1 - 2.8e-15 56.8 15.6 2.8e-15 56.8 10.8 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) DUF3292 PF11696.3 ESS60635.1 - 0.18 9.6 1.7 0.27 9.0 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Grp1_Fun34_YaaH PF01184.14 ESS60636.1 - 0.016 14.5 4.8 0.023 13.9 3.3 1.2 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family DNA_pol_phi PF04931.8 ESS60636.1 - 0.73 7.5 11.8 1 7.0 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi BNR_3 PF13859.1 ESS60645.1 - 1e-123 412.3 9.3 2.4e-123 411.1 6.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60645.1 - 1.2e-18 67.8 0.9 4.6e-18 65.9 0.6 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60645.1 - 1.2e-11 44.2 8.1 2.9e-11 43.0 5.6 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal HTH_15 PF12324.3 ESS60645.1 - 0.043 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase Mucin PF01456.12 ESS60647.1 - 7.2e-05 22.5 14.0 0.00023 20.9 9.7 1.8 1 1 0 1 1 1 1 Mucin-like glycoprotein ELH PF02323.10 ESS60647.1 - 0.15 11.1 1.1 0.2 10.7 0.8 1.3 1 0 0 1 1 1 0 Egg-laying hormone precursor Tr-sialidase_C PF11052.3 ESS60648.1 - 1.3e-05 24.9 3.8 3.7e-05 23.5 2.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M8 PF01457.11 ESS60649.1 - 3.1e-63 213.9 11.8 4.2e-62 210.1 8.2 2.0 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS60649.1 - 3.7e-09 36.2 6.6 6.8e-09 35.4 4.6 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Gemini_AL2 PF01440.11 ESS60649.1 - 0.095 12.7 0.9 7.7 6.6 0.0 2.5 2 0 0 2 2 2 0 Geminivirus AL2 protein BNR_3 PF13859.1 ESS60651.1 - 2e-82 276.7 0.1 3.7e-82 275.8 0.0 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60651.1 - 4.7e-10 39.9 0.4 4.7e-10 39.9 0.3 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Glycos_transf_2 PF00535.21 ESS60653.1 - 0.0011 18.7 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 RVT_3 PF13456.1 ESS60654.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like BNR_3 PF13859.1 ESS60658.1 - 2.6e-131 437.3 2.5 2.6e-131 437.3 1.7 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60658.1 - 1.8e-16 60.7 0.7 5.4e-16 59.2 0.1 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60658.1 - 1.7e-10 40.5 8.7 3.7e-10 39.4 6.1 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60659.1 - 5.7e-27 94.2 17.3 5.7e-27 94.2 12.0 4.3 2 1 0 3 3 3 1 Protein of unknown function (DUF3720) G6B PF15096.1 ESS60660.1 - 0.064 12.7 2.6 0.071 12.6 1.8 1.1 1 0 0 1 1 1 0 G6B family CAML PF14963.1 ESS60660.1 - 0.43 9.8 3.6 0.5 9.6 2.5 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand BNR_3 PF13859.1 ESS60661.1 - 1.6e-135 451.1 6.4 1.6e-135 451.1 4.4 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60662.1 - 1e-09 38.0 16.1 1.9e-09 37.2 11.2 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal EF1G PF00647.14 ESS60663.1 - 1.8e-11 43.6 0.1 2.2e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain Neur_chan_memb PF02932.11 ESS60664.1 - 0.047 13.5 2.2 0.085 12.7 1.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3673 PF12425.3 ESS60664.1 - 1.3 8.9 6.7 0.61 9.9 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3673) Macoilin PF09726.4 ESS60664.1 - 6.4 4.9 11.8 8.7 4.4 8.2 1.1 1 0 0 1 1 1 0 Transmembrane protein BNR_3 PF13859.1 ESS60665.1 - 3e-23 82.3 0.1 4.1e-23 81.9 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS60666.1 - 2.3e-89 299.5 3.5 2.4e-89 299.4 1.2 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60667.1 - 2.7e-10 39.9 14.0 6.8e-10 38.6 9.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS60667.1 - 1.9e-07 31.4 0.0 1.9e-07 31.4 0.0 1.9 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60669.1 - 1.4e-130 434.9 2.5 8.8e-130 432.2 2.9 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60669.1 - 1.3e-17 64.5 1.0 4.5e-17 62.7 0.7 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60669.1 - 1.6e-07 31.0 10.1 3.4e-07 30.0 7.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Neisseria_TspB PF05616.8 ESS60669.1 - 5.6 5.2 7.3 11 4.1 5.1 1.4 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein BNR_3 PF13859.1 ESS60670.1 - 3.7e-129 430.2 5.7 8e-129 429.1 3.9 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60670.1 - 2.7e-16 60.1 2.0 7.7e-16 58.7 0.2 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60670.1 - 9.3e-09 35.0 10.8 9.3e-09 35.0 7.5 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS60673.1 - 2.2e-26 92.3 26.7 2.3e-26 92.2 18.5 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein MGC-24 PF05283.6 ESS60673.1 - 0.35 10.6 16.8 0.35 10.6 11.6 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) TMEM154 PF15102.1 ESS60673.1 - 0.81 9.3 9.2 0.84 9.3 6.4 1.1 1 0 0 1 1 1 0 TMEM154 protein family EspB PF05802.6 ESS60673.1 - 1.4 7.8 5.6 1.4 7.7 3.9 1.0 1 0 0 1 1 1 0 Enterobacterial EspB protein Rubella_E2 PF05749.6 ESS60673.1 - 8.7 5.5 7.6 9.7 5.3 5.3 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 BNR_3 PF13859.1 ESS60676.1 - 2.1e-134 447.4 6.5 2.1e-134 447.4 4.5 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60676.1 - 3.3e-15 56.6 2.3 3.3e-15 56.6 1.6 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60676.1 - 7.7e-10 38.4 9.5 2e-09 37.1 6.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS60679.1 - 2.7e-40 137.4 62.3 4.8e-40 136.6 43.2 1.4 1 1 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS60679.1 - 0.0014 19.2 8.3 0.0017 18.9 5.8 1.1 1 0 0 1 1 1 1 FAM163 family Shisa PF13908.1 ESS60679.1 - 0.078 13.1 12.8 0.11 12.7 8.9 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS60679.1 - 0.3 11.3 6.6 0.42 10.8 4.5 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) MCPVI PF02993.9 ESS60679.1 - 2.9 7.9 9.8 3.5 7.6 6.8 1.1 1 0 0 1 1 1 0 Minor capsid protein VI DUF2413 PF10310.4 ESS60679.1 - 4.1 6.1 6.8 4.4 6.0 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) DUF605 PF04652.11 ESS60679.1 - 5.9 6.1 12.4 6.6 6.0 8.6 1.1 1 0 0 1 1 1 0 Vta1 like PRCC PF10253.4 ESS60679.1 - 7.4 7.2 11.2 11 6.6 7.8 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Dicty_REP PF05086.7 ESS60679.1 - 9.7 3.7 19.4 12 3.5 13.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein BNR_3 PF13859.1 ESS60680.1 - 6e-77 258.7 1.7 8.9e-77 258.1 1.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS60683.1 - 8e-94 314.7 0.3 1.2e-93 314.1 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein CK_II_beta PF01214.13 ESS60686.1 - 2e-58 196.9 0.0 2.5e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Macoilin PF09726.4 ESS60687.1 - 8.2 4.5 9.1 5.1 5.2 4.9 1.6 2 0 0 2 2 2 0 Transmembrane protein DUF1360 PF07098.6 ESS60689.1 - 0.05 13.3 1.6 0.59 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) DNA_pol_phi PF04931.8 ESS60690.1 - 0.65 7.6 11.5 0.92 7.1 8.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Daxx PF03344.10 ESS60690.1 - 2.4 6.5 34.7 3.9 5.8 24.0 1.2 1 0 0 1 1 1 0 Daxx Family Pkinase PF00069.20 ESS60694.1 - 4.1e-49 167.0 0.0 7.5e-49 166.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS60694.1 - 2.2e-26 92.4 0.0 6.1e-26 91.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase LRR_4 PF12799.2 ESS60694.1 - 1.5e-13 50.0 2.4 8.9e-08 31.5 0.0 3.9 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS60694.1 - 1.6e-11 43.7 0.3 2.8e-06 26.9 0.6 3.2 2 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESS60694.1 - 2e-11 42.2 3.4 0.016 15.1 0.0 6.1 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 ESS60694.1 - 1.8e-05 24.2 6.9 0.025 14.7 0.0 5.4 5 0 0 5 5 5 1 Leucine rich repeat LRR_6 PF13516.1 ESS60694.1 - 0.00063 19.5 0.0 0.37 10.9 0.0 4.4 4 0 0 4 4 4 1 Leucine Rich repeat zf-B_box PF00643.19 ESS60694.1 - 0.00092 19.0 4.7 0.00092 19.0 3.2 2.6 2 0 0 2 2 2 1 B-box zinc finger Kinase-like PF14531.1 ESS60694.1 - 0.085 11.8 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like GCV_T PF01571.16 ESS60695.1 - 4.2e-14 52.4 0.0 6.4e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 ESS60695.1 - 2.5e-07 30.6 0.0 4.1e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SET PF00856.23 ESS60696.1 - 6.6e-07 29.7 0.0 1.3e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 SET domain SAF PF08666.7 ESS60696.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 SAF domain DUF966 PF06136.8 ESS60701.1 - 0.93 8.8 16.1 1.4 8.3 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF4407 PF14362.1 ESS60701.1 - 2.1 7.2 11.9 3.8 6.3 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TIL PF01826.12 ESS60703.1 - 0.73 10.0 7.3 0.49 10.5 0.6 2.8 2 0 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain Exo_endo_phos_2 PF14529.1 ESS60704.1 - 6.2e-07 29.0 0.0 2.3e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS60704.1 - 0.00017 21.6 0.4 0.00028 20.8 0.3 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF966 PF06136.8 ESS60707.1 - 7.8 5.8 9.8 15 4.8 6.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF966) RHSP PF07999.6 ESS60710.1 - 0.066 11.7 0.8 0.072 11.6 0.0 1.4 2 0 0 2 2 2 0 Retrotransposon hot spot protein DUF2431 PF10354.4 ESS60710.1 - 0.085 12.8 0.1 0.1 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) DUF3676 PF12429.3 ESS60711.1 - 6.5e-107 356.3 45.5 9.5e-107 355.8 31.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS60711.1 - 8.1e-84 281.3 0.4 8.1e-84 281.3 0.3 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60711.1 - 7e-10 38.6 5.1 1.4e-09 37.6 3.5 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PBP_sp32 PF07222.7 ESS60711.1 - 1.4 8.0 13.7 15 4.6 0.0 2.7 2 1 0 2 2 2 0 Proacrosin binding protein sp32 DUF1178 PF06676.6 ESS60713.1 - 0.16 12.1 0.7 0.4 10.8 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) FAM24 PF15193.1 ESS60713.1 - 0.29 11.3 3.6 0.67 10.1 0.5 2.6 2 0 0 2 2 2 0 FAM24 family BNR_3 PF13859.1 ESS60715.1 - 1.3e-128 428.4 6.3 1.3e-128 428.4 4.3 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60715.1 - 1.5e-15 57.7 0.0 3.9e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60715.1 - 2.2e-07 30.6 6.3 2.2e-07 30.6 4.4 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS60715.1 - 0.035 13.0 0.0 0.073 12.0 0.0 1.4 1 0 0 1 1 1 0 Sialidase, N-terminal domain CENP-R PF06729.7 ESS60717.1 - 0.014 15.0 1.3 0.016 14.8 0.9 1.1 1 0 0 1 1 1 0 Kinetochore component, CENP-R PPR_2 PF13041.1 ESS60718.1 - 1.2e-07 31.5 0.6 0.084 12.8 0.0 5.4 4 1 2 6 6 6 4 PPR repeat family PPR PF01535.15 ESS60718.1 - 3.8e-05 23.3 0.8 1.8 8.7 0.0 3.9 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.1 ESS60718.1 - 0.0072 16.5 0.3 72 4.0 0.0 5.2 5 0 0 5 5 5 0 Pentatricopeptide repeat domain Sld5 PF05916.6 ESS60721.1 - 2.2e-06 27.8 0.0 3.1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein zf-MYND PF01753.13 ESS60722.1 - 7.2e-10 38.5 10.5 7.2e-10 38.5 7.3 1.9 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.1 ESS60722.1 - 0.054 13.3 4.0 0.13 12.1 2.8 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 RVT_1 PF00078.22 ESS60725.1 - 1.7e-31 109.2 0.0 3.5e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESS60725.1 - 1.3e-05 24.8 0.1 3.3e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RHSP PF07999.6 ESS60726.1 - 9e-65 218.9 0.0 9e-65 218.9 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS60727.1 - 1.1e-108 363.7 0.1 1.1e-108 363.7 0.1 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein MAP7 PF05672.6 ESS60727.1 - 0.0017 17.7 24.5 0.0035 16.7 17.0 1.4 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family DUF4337 PF14235.1 ESS60727.1 - 0.0092 15.8 7.0 0.017 14.9 4.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4337) AAA_22 PF13401.1 ESS60727.1 - 0.033 14.3 0.0 7.8 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain U79_P34 PF03064.11 ESS60727.1 - 0.034 13.6 9.5 0.062 12.8 6.6 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 OmpH PF03938.9 ESS60727.1 - 0.29 11.0 9.0 0.76 9.7 6.3 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1682 PF07946.9 ESS60727.1 - 3.2 6.4 17.2 5.8 5.6 11.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DDHD PF02862.12 ESS60727.1 - 4.3 7.0 9.0 2.3 7.9 4.4 1.8 2 0 0 2 2 2 0 DDHD domain Atrophin-1 PF03154.10 ESS60727.1 - 7.7 4.5 20.0 11 4.0 13.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family NPR3 PF03666.8 ESS60727.1 - 9.2 4.6 7.7 14 4.0 5.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Mucin PF01456.12 ESS60729.1 - 1.2e-31 109.4 86.3 3.2e-25 88.5 25.4 2.1 1 1 1 2 2 2 2 Mucin-like glycoprotein Shisa PF13908.1 ESS60729.1 - 0.03 14.5 5.8 0.038 14.1 4.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS60729.1 - 0.038 14.2 0.9 0.042 14.1 0.6 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Pex14_N PF04695.8 ESS60729.1 - 0.086 12.8 2.5 0.092 12.7 1.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1675 PF07897.6 ESS60729.1 - 0.12 12.2 2.7 0.15 11.9 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) LAT PF15234.1 ESS60729.1 - 0.23 10.9 6.0 0.32 10.4 4.1 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells PRCC PF10253.4 ESS60729.1 - 0.71 10.5 4.4 0.79 10.3 3.0 1.0 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF1180 PF06679.7 ESS60729.1 - 1.2 8.9 9.9 1.7 8.4 6.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Phosphoprotein PF00922.12 ESS60729.1 - 2 7.5 6.3 2.3 7.3 4.3 1.0 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein DUF4366 PF14283.1 ESS60729.1 - 3 7.2 10.9 2.5 7.4 6.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF3530 PF12048.3 ESS60729.1 - 3.3 6.6 11.2 8.8 5.2 7.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) Mucin PF01456.12 ESS60733.1 - 4.9e-32 110.6 57.2 9.3e-31 106.5 39.6 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS60733.1 - 0.012 16.2 5.4 0.013 16.0 3.8 1.2 1 0 0 1 1 1 0 FAM163 family MGC-24 PF05283.6 ESS60733.1 - 0.033 13.9 22.4 0.043 13.6 15.5 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Shisa PF13908.1 ESS60733.1 - 0.044 13.9 8.1 0.057 13.5 5.6 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1675 PF07897.6 ESS60733.1 - 0.11 12.3 3.8 0.14 12.0 2.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Pex14_N PF04695.8 ESS60733.1 - 0.16 12.0 3.9 0.17 11.9 2.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2360 PF10152.4 ESS60733.1 - 0.26 11.5 4.8 0.3 11.3 3.3 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) MCPVI PF02993.9 ESS60733.1 - 0.57 10.2 4.5 0.66 10.0 3.1 1.0 1 0 0 1 1 1 0 Minor capsid protein VI Phosphoprotein PF00922.12 ESS60733.1 - 1.8 7.7 7.2 2 7.5 5.0 1.0 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein Dicty_REP PF05086.7 ESS60733.1 - 2.4 5.8 12.1 2.7 5.6 8.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4366 PF14283.1 ESS60733.1 - 2.5 7.4 12.1 0.72 9.2 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) PRCC PF10253.4 ESS60733.1 - 2.7 8.6 7.9 3.1 8.4 5.5 1.0 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF1180 PF06679.7 ESS60733.1 - 4.3 7.2 10.5 5.7 6.7 7.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Glyco_transf_43 PF03360.11 ESS60735.1 - 0.00096 18.7 0.1 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 43 Cullin_Nedd8 PF10557.4 ESS60737.1 - 7.3e-16 57.7 0.2 2.1e-15 56.2 0.1 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.17 ESS60737.1 - 4.4e-07 28.8 0.0 1.1e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 Cullin family Plasmid_stab_B PF10784.4 ESS60737.1 - 0.058 13.0 0.0 1.2 8.7 0.0 3.0 3 0 0 3 3 3 0 Plasmid stability protein Aa_trans PF01490.13 ESS60739.1 - 5.4e-53 179.9 28.4 5.4e-53 179.9 19.7 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 ESS60739.1 - 5.2e-06 25.2 6.6 5.2e-06 25.2 4.6 2.8 2 1 0 3 3 3 1 Amino acid permease Trp_Tyr_perm PF03222.8 ESS60739.1 - 0.03 13.1 37.6 0.0078 15.0 20.3 2.8 2 1 0 2 2 2 0 Tryptophan/tyrosine permease family Cytochrom_B_C PF00032.12 ESS60739.1 - 0.13 12.5 0.1 0.13 12.5 0.1 3.7 4 1 0 4 4 4 0 Cytochrome b(C-terminal)/b6/petD RVT_1 PF00078.22 ESS60741.1 - 9.7e-28 96.9 0.0 1.2e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sec16_N PF12935.2 ESS60743.1 - 0.052 13.4 3.9 0.064 13.1 2.7 1.1 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus DUF4569 PF15133.1 ESS60743.1 - 0.28 10.5 2.4 0.39 10.0 1.5 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4569) Glyco_transf_22 PF03901.12 ESS60744.1 - 8.3 5.2 5.3 11 4.9 3.7 1.1 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family BNR_3 PF13859.1 ESS60745.1 - 1.4e-12 47.3 0.0 1.9e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60747.1 - 5.4e-10 38.9 8.8 1e-09 38.0 6.1 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal NADH-G_4Fe-4S_3 PF10588.4 ESS60748.1 - 0.022 14.0 0.5 0.056 12.6 0.3 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region ZU5 PF00791.15 ESS60748.1 - 0.14 11.8 0.4 0.17 11.5 0.3 1.2 1 0 0 1 1 1 0 ZU5 domain DUF1397 PF07165.6 ESS60749.1 - 0.0021 17.3 0.9 0.0034 16.6 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1397) BNR_3 PF13859.1 ESS60750.1 - 3.2e-56 190.6 8.5 2.4e-48 164.8 0.7 2.8 2 1 1 3 3 3 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60750.1 - 2.5e-19 70.0 1.9 4.5e-19 69.2 1.3 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60750.1 - 2.4e-09 36.8 10.2 6e-09 35.6 7.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS60753.1 - 4.1e-18 66.1 0.3 9.6e-18 64.9 0.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60753.1 - 2.6e-12 46.3 9.0 4.8e-12 45.5 6.2 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS60753.1 - 0.0082 16.1 0.1 0.035 14.1 0.0 2.1 2 0 0 2 2 2 1 Laminin G domain Alginate_exp PF13372.1 ESS60753.1 - 0.01 14.4 0.1 0.015 13.9 0.0 1.2 1 0 0 1 1 1 0 Alginate export NST1 PF13945.1 ESS60754.1 - 1.4 8.9 6.8 2 8.4 4.7 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Laminin_G_3 PF13385.1 ESS60758.1 - 4.3e-06 27.0 0.0 5.2e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60761.1 - 6.2e-64 216.0 3.8 7.9e-64 215.6 2.6 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS60762.1 - 6e-63 212.7 3.4 2.3e-62 210.8 0.1 2.5 2 1 0 2 2 2 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60762.1 - 2.4e-15 57.0 0.1 4.9e-15 56.1 0.1 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily XLF PF09302.6 ESS60763.1 - 0.12 12.1 0.5 0.32 10.7 0.0 1.7 1 1 1 2 2 2 0 XLF (XRCC4-like factor) Daxx PF03344.10 ESS60764.1 - 0.049 12.1 27.0 0.061 11.8 18.7 1.1 1 0 0 1 1 1 0 Daxx Family Utp14 PF04615.8 ESS60764.1 - 0.87 7.6 27.0 1.1 7.3 18.7 1.0 1 0 0 1 1 1 0 Utp14 protein Peptidase_M8 PF01457.11 ESS60765.1 - 2.8e-79 266.8 10.0 7.5e-78 262.1 6.9 2.0 1 1 0 1 1 1 1 Leishmanolysin DUF3810 PF12725.2 ESS60765.1 - 0.19 10.5 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Daxx PF03344.10 ESS60767.1 - 2.6 6.4 38.7 4 5.8 26.8 1.3 1 0 0 1 1 1 0 Daxx Family CASP_C PF08172.7 ESS60768.1 - 0.18 10.8 1.3 0.24 10.4 0.9 1.3 1 1 0 1 1 1 0 CASP C terminal GKAP PF03359.8 ESS60768.1 - 3.6 7.0 6.4 0.6 9.6 1.7 1.6 1 1 1 2 2 2 0 Guanylate-kinase-associated protein (GKAP) protein MGC-24 PF05283.6 ESS60768.1 - 4.3 7.0 7.2 4.9 6.9 4.4 1.6 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Exo_endo_phos PF03372.18 ESS60770.1 - 4.6e-05 23.4 0.0 0.00013 21.9 0.0 1.6 1 1 1 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DGF-1_5 PF11038.3 ESS60771.1 - 1.8e-159 529.3 18.4 7.5e-159 527.2 12.7 2.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS60771.1 - 2.1e-34 117.7 16.2 2.1e-34 117.7 11.2 2.3 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS60771.1 - 4.6e-28 96.9 1.8 1.3e-27 95.4 1.3 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Beta_helix PF13229.1 ESS60771.1 - 1.1e-05 25.2 6.5 0.11 12.2 0.1 5.0 3 1 1 4 4 4 2 Right handed beta helix region Pkinase PF00069.20 ESS60772.1 - 2.6e-38 131.6 0.0 3.3e-38 131.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS60772.1 - 5.1e-19 68.3 0.0 5.7e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS60772.1 - 8.3e-05 21.6 0.0 0.00042 19.3 0.0 1.9 2 0 0 2 2 2 1 Kinase-like G6PD_N PF00479.17 ESS60775.1 - 1.1e-59 201.8 0.0 1.7e-59 201.1 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain G6PD_C PF02781.11 ESS60775.1 - 1.3e-30 106.2 0.0 1.9e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain HPP PF04982.8 ESS60776.1 - 1e-16 60.8 9.8 1e-16 60.8 6.8 1.6 2 0 0 2 2 2 1 HPP family Mab-21 PF03281.9 ESS60777.1 - 0.052 12.6 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Mab-21 protein MCM PF00493.18 ESS60778.1 - 5.7e-98 327.7 0.0 7.7e-98 327.3 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family AAA_5 PF07728.9 ESS60778.1 - 2e-09 37.2 0.0 3.8e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS60778.1 - 3.6e-05 23.0 1.3 0.1 11.7 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESS60778.1 - 0.00099 18.7 0.0 0.0022 17.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS60778.1 - 0.016 14.2 0.0 0.033 13.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ESS60778.1 - 0.026 14.4 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESS60778.1 - 0.03 14.2 0.6 0.093 12.7 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.24 ESS60778.1 - 0.032 14.4 0.0 0.1 12.8 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Desulfoferrod_N PF06397.7 ESS60778.1 - 0.047 13.0 0.2 0.14 11.5 0.1 1.8 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain Ribosomal_S11 PF00411.14 ESS60779.1 - 0.096 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S11 PET PF06297.9 ESS60779.1 - 0.12 12.0 0.1 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 PET Domain Pyr_redox_2 PF07992.9 ESS60780.1 - 1.8e-35 122.6 0.0 5.1e-35 121.1 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESS60780.1 - 3e-24 85.1 0.0 6.8e-24 84.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ESS60780.1 - 8.9e-22 77.2 0.8 8.2e-18 64.5 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESS60780.1 - 4.9e-07 28.9 1.8 0.0025 16.7 0.4 2.5 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_3 PF13738.1 ESS60780.1 - 1e-05 25.7 0.1 0.0044 17.0 0.0 3.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ESS60780.1 - 2.2e-05 23.1 0.3 0.012 14.1 0.1 2.6 2 0 0 2 2 2 2 HI0933-like protein GIDA PF01134.17 ESS60780.1 - 0.0011 17.8 1.3 0.0016 17.4 0.2 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 ESS60780.1 - 0.0015 17.6 0.0 0.058 12.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.19 ESS60780.1 - 0.0031 16.4 0.6 0.031 13.1 0.2 2.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.12 ESS60780.1 - 0.037 13.1 0.1 0.073 12.1 0.1 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.1 ESS60780.1 - 0.083 12.9 0.3 0.18 11.8 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 ESS60780.1 - 0.11 11.4 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.7 ESS60780.1 - 0.12 11.3 0.1 3.4 6.4 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein DEAD PF00270.24 ESS60781.1 - 1.2e-40 138.7 0.0 2.1e-40 138.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS60781.1 - 1e-22 79.7 0.0 5.7e-21 74.1 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS60781.1 - 0.00012 21.9 0.3 0.0035 17.1 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESS60781.1 - 0.04 12.7 0.0 0.068 11.9 0.0 1.4 1 0 0 1 1 1 0 SNF2 family N-terminal domain Glutaredoxin PF00462.19 ESS60783.1 - 8.8e-14 51.2 0.0 1.2e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin RHSP PF07999.6 ESS60785.1 - 3.9e-103 345.3 0.0 4.6e-103 345.1 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS60786.1 - 2.6e-105 352.5 1.4 4.2e-105 351.8 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60786.1 - 0.017 15.2 0.0 3.6 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Peptidase_C33 PF05412.7 ESS60788.1 - 0.022 14.5 0.0 0.066 13.0 0.0 1.8 2 0 0 2 2 2 0 Equine arterivirus Nsp2-type cysteine proteinase Amidase02_C PF12123.3 ESS60789.1 - 0.092 12.4 0.2 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 N-acetylmuramoyl-l-alanine amidase BNR_3 PF13859.1 ESS60791.1 - 2.5e-129 430.8 7.3 2.5e-129 430.8 5.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60791.1 - 1e-17 64.8 2.4 1e-17 64.8 1.6 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60791.1 - 2.6e-10 39.9 13.5 6e-10 38.8 9.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PPV_E2_N PF00508.12 ESS60795.1 - 0.053 12.7 0.0 0.058 12.5 0.0 1.1 1 0 0 1 1 1 0 E2 (early) protein, N terminal Mucin PF01456.12 ESS60797.1 - 3.9e-26 91.5 33.0 4.3e-26 91.3 22.9 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS60797.1 - 0.93 9.3 3.7 2.4 8.0 2.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) TraV PF09676.5 ESS60797.1 - 1.3 9.7 6.0 1.5 9.5 4.2 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DUF572 PF04502.8 ESS60797.1 - 1.6 7.8 5.3 1.7 7.7 3.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lamp PF01299.12 ESS60797.1 - 4.5 6.3 10.8 5.6 6.0 7.5 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) MGC-24 PF05283.6 ESS60797.1 - 9.7 5.9 20.3 11 5.7 14.1 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) BNR_3 PF13859.1 ESS60798.1 - 1.9e-118 395.0 6.7 2.5e-118 394.6 2.2 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60798.1 - 1.3e-17 64.4 1.5 1.3e-17 64.4 1.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60798.1 - 5.7e-08 32.4 11.4 1.4e-07 31.2 7.9 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Vps39_1 PF10366.4 ESS60798.1 - 0.017 15.1 0.2 0.056 13.4 0.1 1.9 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 BNR_3 PF13859.1 ESS60800.1 - 7.3e-129 429.2 5.9 1.2e-128 428.5 4.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60800.1 - 6.2e-17 62.2 1.1 1.6e-16 60.9 0.7 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60800.1 - 2.7e-09 36.7 10.6 3.4e-09 36.4 4.9 2.5 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Topo_Zn_Ribbon PF08272.6 ESS60800.1 - 0.17 11.2 1.1 0.81 9.0 0.3 2.3 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like DUF2826 PF11442.3 ESS60804.1 - 2.1e-91 303.7 7.5 2.5e-91 303.5 5.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) RHSP PF07999.6 ESS60806.1 - 4.8e-109 364.8 0.0 6.9e-109 364.3 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60806.1 - 0.0018 18.4 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain RHSP PF07999.6 ESS60808.1 - 1.2e-99 333.8 1.2 1.6e-99 333.4 0.9 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS60808.1 - 0.061 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain RHSP PF07999.6 ESS60809.1 - 0.047 12.2 0.0 0.072 11.6 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon hot spot protein RHSP PF07999.6 ESS60811.1 - 1.2e-94 317.3 2.4 1.2e-94 317.3 1.6 2.2 2 1 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60811.1 - 0.061 13.4 0.0 7.4 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain BNR_3 PF13859.1 ESS60812.1 - 2.6e-126 420.8 11.5 5e-126 419.9 8.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60812.1 - 1.3e-17 64.5 0.3 5.3e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60812.1 - 2.6e-10 39.9 9.7 2.6e-10 39.9 6.8 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS60812.1 - 0.011 15.8 0.1 0.025 14.5 0.1 1.6 1 0 0 1 1 1 0 Laminin G domain Mucin PF01456.12 ESS60813.1 - 0.072 12.8 1.9 0.081 12.6 1.3 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS60821.1 - 4.6e-131 436.5 6.3 1.1e-130 435.2 4.4 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60821.1 - 1.4e-15 57.8 0.7 1.4e-15 57.8 0.5 2.4 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60821.1 - 1e-10 41.2 8.8 3e-10 39.7 6.1 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS60821.1 - 8.5 6.1 13.1 1.2 8.8 4.2 2.7 2 1 0 2 2 2 0 Mucin-like glycoprotein GON PF08685.6 ESS60822.1 - 0.083 12.7 0.6 0.12 12.2 0.4 1.2 1 0 0 1 1 1 0 GON domain Mucin PF01456.12 ESS60825.1 - 1.4e-39 135.0 39.3 6.3e-36 123.2 27.2 2.1 1 1 0 1 1 1 1 Mucin-like glycoprotein DUF605 PF04652.11 ESS60825.1 - 0.0074 15.7 13.2 0.009 15.4 9.2 1.1 1 0 0 1 1 1 1 Vta1 like Mucin PF01456.12 ESS60828.1 - 1e-22 80.4 40.0 3.3e-22 78.7 27.7 1.8 1 1 0 1 1 1 1 Mucin-like glycoprotein Herpes_TAF50 PF03326.8 ESS60828.1 - 0.04 12.8 10.6 0.044 12.7 7.3 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Menin PF05053.8 ESS60828.1 - 4.7 5.2 6.9 5.4 5.0 4.8 1.1 1 0 0 1 1 1 0 Menin DUF1675 PF07897.6 ESS60828.1 - 6.3 6.5 12.4 10 5.9 8.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) BNR_3 PF13859.1 ESS60830.1 - 2.5e-36 125.3 1.6 3.9e-36 124.7 0.3 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60830.1 - 1.4e-16 61.1 1.8 3.2e-16 59.9 1.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60830.1 - 0.027 14.3 0.6 0.027 14.3 0.4 1.9 2 0 0 2 2 2 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60832.1 - 7.3e-89 297.8 0.5 7.3e-89 297.8 0.4 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60832.1 - 3.5e-18 66.3 0.1 9.7e-18 64.8 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60832.1 - 1.4e-11 43.9 13.0 3.2e-11 42.8 9.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Dockerin_1 PF00404.13 ESS60832.1 - 2.9 7.7 6.0 2 8.2 0.1 3.1 3 0 0 3 3 3 0 Dockerin type I repeat Mucin PF01456.12 ESS60835.1 - 0.69 9.6 12.4 0.39 10.5 7.5 1.7 1 1 0 1 1 1 0 Mucin-like glycoprotein RHSP PF07999.6 ESS60836.1 - 3.8e-67 226.7 0.2 5.1e-67 226.3 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS60837.1 - 5e-164 544.2 18.0 5e-164 544.2 12.5 2.9 4 0 0 4 4 4 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60837.1 - 9.3e-49 163.2 0.7 9.3e-49 163.2 0.5 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS60837.1 - 1.2e-39 134.5 16.3 1.2e-39 134.5 11.3 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS60841.1 - 4.9e-05 23.1 5.5 0.043 13.5 0.0 4.5 3 2 0 4 4 4 3 Right handed beta helix region cEGF PF12662.2 ESS60841.1 - 2 8.1 8.9 0.63 9.7 0.7 3.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like Fer4_19 PF06902.6 ESS60842.1 - 0.21 11.4 2.0 1.1 9.1 0.0 2.3 1 1 1 2 2 2 0 Divergent 4Fe-4S mono-cluster Laminin_G_3 PF13385.1 ESS60843.1 - 9.6e-08 32.4 0.3 1.1e-07 32.1 0.2 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS60844.1 - 3.8e-29 101.7 0.7 4.2e-29 101.5 0.5 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS60844.1 - 0.0063 16.1 4.6 0.11 12.3 0.2 2.9 3 0 0 3 3 3 2 BNR/Asp-box repeat Ras PF00071.17 ESS60846.1 - 4.3e-46 156.2 0.0 5.1e-46 156.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS60846.1 - 2.5e-17 63.4 0.0 4e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS60846.1 - 1.3e-16 60.3 0.0 1.6e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESS60846.1 - 8.8e-06 25.0 0.0 1e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESS60846.1 - 3.1e-05 23.4 0.0 5.6e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESS60846.1 - 7.6e-05 22.6 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESS60846.1 - 0.0021 17.2 0.1 0.0069 15.5 0.0 1.9 3 0 0 3 3 3 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESS60846.1 - 0.0061 16.0 0.0 0.0088 15.5 0.0 1.3 1 1 0 1 1 1 1 AAA-like domain AAA_24 PF13479.1 ESS60846.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS60846.1 - 0.013 15.7 0.1 0.016 15.5 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 ESS60846.1 - 0.022 14.3 0.1 0.061 12.8 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain YTH PF04146.10 ESS60846.1 - 0.029 13.9 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 YT521-B-like domain AAA_23 PF13476.1 ESS60846.1 - 0.077 13.3 0.0 0.085 13.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS60846.1 - 0.12 12.3 0.5 0.21 11.5 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 ESS60846.1 - 0.14 11.8 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arteri_nucleo PF01481.11 ESS60847.1 - 0.34 11.0 1.6 19 5.3 0.1 2.9 3 0 0 3 3 3 0 Arterivirus nucleocapsid protein BNR_3 PF13859.1 ESS60848.1 - 3.9e-131 436.7 2.1 5.9e-131 436.1 0.4 2.1 2 1 1 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60848.1 - 2.8e-17 63.3 4.3 1e-16 61.5 1.3 2.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60848.1 - 0.0001 22.0 5.9 0.0001 22.0 4.1 2.4 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Hamartin PF04388.7 ESS60849.1 - 0.08 11.6 2.5 0.092 11.4 1.7 1.0 1 0 0 1 1 1 0 Hamartin protein MMR1 PF08505.5 ESS60849.1 - 1.2 9.0 6.1 1.8 8.5 4.2 1.3 1 1 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein BNR_3 PF13859.1 ESS60852.1 - 5.3e-94 314.7 2.4 1.1e-93 313.7 1.7 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60852.1 - 9.6e-17 61.6 1.1 2.1e-16 60.5 0.8 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60852.1 - 2.1e-07 30.6 13.2 2.1e-07 30.6 9.2 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60854.1 - 7.4e-128 425.9 6.4 1.4e-127 425.0 3.4 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60854.1 - 7.7e-17 61.9 1.0 7.7e-17 61.9 0.7 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60854.1 - 2.8e-08 33.4 7.3 2.8e-08 33.4 5.1 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS60857.1 - 1.3e-49 168.9 0.0 2e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS60858.1 - 7.3e-156 517.4 17.3 7.3e-156 517.4 12.0 2.9 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60858.1 - 6.4e-47 157.3 1.9 6.4e-47 157.3 1.3 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS60858.1 - 2.4e-31 107.9 18.7 8.6e-31 106.1 13.0 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS60858.1 - 4.3e-05 23.3 11.9 0.026 14.2 0.0 6.1 3 2 1 4 4 4 2 Right handed beta helix region BNR_3 PF13859.1 ESS60861.1 - 1.9e-131 437.7 3.9 4.1e-131 436.6 2.7 1.6 1 0 0 1 1 1 1 BNR repeat-like domain DXP_redisom_C PF08436.7 ESS60862.1 - 0.13 12.1 0.2 0.38 10.6 0.0 1.8 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal Macoilin PF09726.4 ESS60862.1 - 1.7 6.8 8.7 1.9 6.6 6.0 1.0 1 0 0 1 1 1 0 Transmembrane protein RHSP PF07999.6 ESS60863.1 - 7.4e-83 278.5 0.0 1e-82 278.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Nit_Regul_Hom PF10126.4 ESS60863.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII AAA_10 PF12846.2 ESS60863.1 - 0.15 11.4 0.0 0.22 10.9 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain RHSP PF07999.6 ESS60864.1 - 0.005 15.4 0.2 0.01 14.4 0.1 1.5 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3886 PF13025.1 ESS60864.1 - 0.01 15.7 15.1 0.033 14.1 2.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) DUF2570 PF10828.3 ESS60864.1 - 0.64 9.6 3.6 17 5.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) BNR_3 PF13859.1 ESS60867.1 - 1.5e-57 195.0 0.3 2.5e-57 194.3 0.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60867.1 - 3.2e-13 50.2 1.1 1.5e-12 47.9 0.0 2.5 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60867.1 - 4.6e-10 39.1 6.4 1e-09 38.0 4.4 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS60867.1 - 0.18 11.7 8.0 0.11 12.3 0.4 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat RHSP PF07999.6 ESS60870.1 - 1.6e-102 343.3 0.3 2.5e-102 342.7 0.0 1.4 2 0 0 2 2 2 1 Retrotransposon hot spot protein FcoT PF10862.3 ESS60870.1 - 0.16 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 FcoT-like thioesterase domain DGF-1_C PF11040.3 ESS60871.1 - 3e-47 158.4 1.5 4.8e-47 157.7 1.0 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS60871.1 - 3.4e-21 75.6 3.3 3.4e-21 75.6 2.3 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 Glycos_transf_4 PF00953.16 ESS60871.1 - 3.1 7.5 13.3 1 9.1 6.5 2.0 1 1 1 2 2 2 0 Glycosyl transferase family 4 SID-1_RNA_chan PF13965.1 ESS60871.1 - 8.2 4.4 9.9 14 3.6 6.9 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DGF-1_4 PF11024.3 ESS60872.1 - 1.5e-31 108.6 14.9 1.5e-31 108.6 10.3 2.3 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF3568 PF12092.3 ESS60872.1 - 5.8 6.6 7.6 4.8 6.8 0.7 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3568) DGF-1_C PF11040.3 ESS60873.1 - 1.6e-48 162.4 1.9 1.6e-48 162.4 1.3 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS60873.1 - 6.6e-11 41.9 1.3 6.6e-11 41.9 0.9 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 RHSP PF07999.6 ESS60874.1 - 1.4e-19 69.9 0.0 2.1e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein HGWP PF03578.10 ESS60874.1 - 0.098 11.9 0.4 0.22 10.8 0.3 1.5 1 0 0 1 1 1 0 HGWP repeat eIF-1a PF01176.14 ESS60875.1 - 7.4e-05 22.1 1.3 0.00012 21.3 0.9 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 CFIA_Pcf11 PF11526.3 ESS60875.1 - 0.029 14.5 0.2 0.044 13.9 0.2 1.2 1 0 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 Glucosamine_iso PF01182.15 ESS60876.1 - 1.5e-46 158.6 0.0 1.7e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sedlin_N PF04628.8 ESS60877.1 - 2.3e-25 88.9 0.0 2.6e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 ESS60877.1 - 0.0033 17.1 0.0 0.0044 16.7 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family ASF1_hist_chap PF04729.8 ESS60878.1 - 1.1e-26 93.3 0.0 1.3e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone Ribosomal_L17 PF01196.14 ESS60879.1 - 2.1e-12 47.4 0.0 3.1e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 RVT_1 PF00078.22 ESS60881.1 - 3.9e-34 117.8 0.0 9.7e-34 116.5 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Endomucin PF07010.7 ESS60885.1 - 0.039 13.3 0.1 0.042 13.1 0.1 1.1 1 0 0 1 1 1 0 Endomucin PhaC_N PF07167.8 ESS60887.1 - 0.1 12.0 0.1 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Laminin_G_3 PF13385.1 ESS60890.1 - 1.9e-11 44.4 0.2 2.5e-11 44.0 0.1 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 ESS60890.1 - 0.0038 17.2 0.0 0.0044 17.0 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.18 ESS60890.1 - 0.076 13.0 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain BNR_3 PF13859.1 ESS60895.1 - 4.9e-75 252.4 2.2 6.3e-75 252.1 1.6 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Cytochrome_C554 PF13435.1 ESS60896.1 - 0.1 12.6 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 Cytochrome c554 and c-prime DUF3676 PF12429.3 ESS60899.1 - 2.2e-106 354.6 48.6 3.3e-106 354.0 33.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS60899.1 - 6e-84 281.7 0.5 6e-84 281.7 0.4 2.7 2 1 1 3 3 3 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60899.1 - 2.9e-10 39.8 5.6 2.9e-10 39.8 3.9 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal cEGF PF12662.2 ESS60906.1 - 0.022 14.4 1.0 0.022 14.4 0.7 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like hEGF PF12661.2 ESS60906.1 - 0.75 10.0 7.0 0.71 10.0 0.9 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF DGF-1_4 PF11024.3 ESS60907.1 - 1.8e-31 108.3 19.5 4.4e-31 107.0 13.5 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS60907.1 - 0.0017 18.1 4.5 0.008 15.9 2.0 2.8 3 0 0 3 3 3 1 Right handed beta helix region DGF-1_5 PF11038.3 ESS60908.1 - 1.5e-129 431.1 21.9 2.8e-129 430.2 15.2 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60908.1 - 1.3e-49 165.9 2.0 3e-49 164.8 1.4 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF1129 PF06570.6 ESS60908.1 - 0.021 14.1 0.9 0.1 11.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Laminin_G_3 PF13385.1 ESS60909.1 - 1.6e-13 51.2 0.3 4e-13 49.8 0.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60909.1 - 4.9e-10 39.0 10.3 1e-09 38.0 7.1 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60910.1 - 2.5e-127 424.2 5.7 3.2e-127 423.8 4.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS60910.1 - 2.6e-06 26.9 0.1 5.9e-06 25.7 0.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Exo_endo_phos PF03372.18 ESS60911.1 - 2.6e-05 24.3 0.5 4.3e-05 23.5 0.0 1.6 1 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DGF-1_5 PF11038.3 ESS60912.1 - 6.6e-160 530.7 18.2 6.6e-160 530.7 12.6 2.5 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60912.1 - 2.4e-48 161.9 2.4 2.4e-48 161.9 1.7 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS60912.1 - 1e-32 112.3 18.4 1e-32 112.3 12.7 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 zf-CCCH PF00642.19 ESS60913.1 - 3.3e-05 23.4 2.7 3.3e-05 23.4 1.9 2.8 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.19 ESS60914.1 - 0.00013 21.5 6.8 0.00028 20.4 4.7 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS60914.1 - 0.17 11.9 7.2 0.33 11.0 5.0 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Sclerostin PF05463.6 ESS60919.1 - 0.011 15.1 0.6 0.011 15.1 0.4 1.4 1 1 0 1 1 1 0 Sclerostin (SOST) RHSP PF07999.6 ESS60921.1 - 0.00072 18.2 0.2 0.0015 17.2 0.1 1.5 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS60922.1 - 2.3e-21 75.8 0.1 2.5e-21 75.8 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein zf-LITAF-like PF10601.4 ESS60924.1 - 0.01 15.6 1.4 0.014 15.2 1.0 1.2 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain CtaG_Cox11 PF04442.9 ESS60924.1 - 0.025 14.3 0.7 0.035 13.8 0.5 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein CtaG/Cox11 zf-ribbon_3 PF13248.1 ESS60924.1 - 0.044 13.0 1.2 0.044 13.0 0.9 2.4 3 0 0 3 3 3 0 zinc-ribbon domain Menin PF05053.8 ESS60925.1 - 2 6.4 5.8 2.8 6.0 4.0 1.1 1 0 0 1 1 1 0 Menin DUF35_N PF12172.3 ESS60926.1 - 6.5 6.8 7.7 0.96 9.4 0.1 3.1 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) AA_permease_N PF08403.5 ESS60927.1 - 0.077 12.3 0.1 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Amino acid permease N-terminal RHSP PF07999.6 ESS60928.1 - 7.6e-103 344.4 0.3 1.3e-102 343.6 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60928.1 - 0.039 14.0 0.3 0.59 10.2 0.0 2.9 4 1 0 4 4 4 0 AAA domain HPP PF04982.8 ESS60930.1 - 0.18 11.6 1.7 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 HPP family SIT PF15330.1 ESS60930.1 - 0.43 10.7 0.0 0.43 10.7 0.0 3.1 4 0 0 4 4 4 0 SHP2-interacting transmembrane adaptor protein, SIT ATG16 PF08614.6 ESS60932.1 - 0.00026 20.8 0.6 0.00031 20.6 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Cast PF10174.4 ESS60932.1 - 0.011 13.8 4.0 0.015 13.3 2.8 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone bZIP_2 PF07716.10 ESS60932.1 - 0.017 14.9 3.0 1.7 8.5 0.1 2.4 2 0 0 2 2 2 0 Basic region leucine zipper APG6 PF04111.7 ESS60932.1 - 0.024 13.6 0.7 0.032 13.2 0.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DASH_Dad2 PF08654.5 ESS60932.1 - 0.085 12.8 2.1 0.87 9.6 0.2 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 Ctr PF04145.10 ESS60932.1 - 0.14 12.2 1.1 0.21 11.5 0.8 1.4 1 1 0 1 1 1 0 Ctr copper transporter family DivIC PF04977.10 ESS60932.1 - 0.23 10.9 1.8 6.3 6.3 0.2 2.2 1 1 1 2 2 2 0 Septum formation initiator ADIP PF11559.3 ESS60932.1 - 0.63 9.9 5.9 2 8.3 4.0 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding HALZ PF02183.13 ESS60932.1 - 0.77 9.5 5.3 3.5 7.4 0.7 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.4 ESS60932.1 - 0.92 9.3 4.8 1.8 8.4 3.3 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.1 ESS60932.1 - 1.4 8.0 3.9 6.2 5.9 2.7 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Tetraspannin PF00335.15 ESS60933.1 - 0.079 12.2 7.9 0.14 11.3 5.5 1.3 1 0 0 1 1 1 0 Tetraspanin family Abhydrolase_6 PF12697.2 ESS60934.1 - 4.6e-29 101.9 0.6 6.5e-29 101.4 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS60934.1 - 2.5e-12 46.7 0.0 3.7e-12 46.2 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS60934.1 - 3e-10 40.0 0.1 9.1e-10 38.4 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESS60934.1 - 8.7e-05 22.2 0.0 0.00021 21.0 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase PGAP1 PF07819.8 ESS60934.1 - 0.011 15.3 0.1 0.028 14.0 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein Thioesterase PF00975.15 ESS60934.1 - 0.015 15.5 0.6 0.061 13.5 0.4 2.0 1 1 0 1 1 1 0 Thioesterase domain DUF2305 PF10230.4 ESS60934.1 - 0.02 14.3 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Esterase PF00756.15 ESS60934.1 - 0.034 13.5 0.1 1.3 8.3 0.0 2.5 2 0 0 2 2 2 0 Putative esterase AAA_33 PF13671.1 ESS60935.1 - 2.6e-07 30.5 1.4 1.5e-06 28.1 0.2 2.7 2 2 0 2 2 2 1 AAA domain tRNA_lig_kinase PF08303.6 ESS60935.1 - 3.3e-07 30.3 0.0 5.2e-06 26.4 0.0 2.1 1 1 0 1 1 1 1 tRNA ligase kinase domain AAA_16 PF13191.1 ESS60935.1 - 9.6e-05 22.4 0.9 0.00045 20.2 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 ESS60935.1 - 0.0048 17.2 0.0 0.0073 16.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 ESS60935.1 - 0.0064 16.6 0.1 0.043 13.9 0.0 2.0 1 1 1 2 2 2 1 AAA domain MobB PF03205.9 ESS60935.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 ESS60935.1 - 0.027 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 ESS60935.1 - 0.031 13.8 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF4158 PF13700.1 ESS60935.1 - 0.052 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) AAA_5 PF07728.9 ESS60935.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 ESS60935.1 - 0.098 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 RNA helicase PRK PF00485.13 ESS60935.1 - 0.16 11.4 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 ESS60935.1 - 1.2 10.0 3.9 1.4 9.7 1.0 2.4 2 2 0 2 2 2 0 AAA domain Hus1 PF04005.7 ESS60936.1 - 1.2e-32 113.0 0.0 1.5e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein zf-RING_5 PF14634.1 ESS60937.1 - 0.00016 21.3 9.6 0.0005 19.7 6.7 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESS60937.1 - 0.00017 21.5 6.5 0.0019 18.1 4.5 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS60937.1 - 0.00033 20.2 8.2 0.0006 19.4 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESS60937.1 - 0.00082 19.0 2.2 0.0043 16.7 1.4 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESS60937.1 - 0.00084 19.0 3.6 0.008 15.9 2.5 2.1 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 ESS60937.1 - 0.00095 18.9 10.2 0.0017 18.1 7.1 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 ESS60937.1 - 0.18 11.6 12.5 0.062 13.1 6.7 1.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_3 PF13920.1 ESS60937.1 - 0.35 10.5 9.3 0.4 10.3 5.0 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peptidase_M8 PF01457.11 ESS60938.1 - 3.1e-40 138.0 0.0 3.3e-40 137.9 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESS60938.1 - 0.033 13.9 0.0 0.052 13.2 0.0 1.5 1 1 0 1 1 1 0 Matrixin BNR_3 PF13859.1 ESS60940.1 - 1.8e-86 290.0 5.1 1.7e-51 175.1 0.6 2.2 1 1 1 2 2 2 2 BNR repeat-like domain Galactosyl_T PF01762.16 ESS60941.1 - 1.6e-09 37.6 0.0 0.0004 20.0 0.0 3.2 2 1 1 3 3 3 2 Galactosyltransferase BNR_3 PF13859.1 ESS60943.1 - 1.7e-58 198.1 0.0 2.4e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS60943.1 - 5.3e-06 25.9 2.1 0.00016 21.0 0.6 2.7 1 1 1 3 3 3 2 BNR repeat-like domain BNR PF02012.15 ESS60943.1 - 0.079 12.8 9.7 0.91 9.6 0.2 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat Glycos_transf_2 PF00535.21 ESS60945.1 - 0.00019 21.1 0.0 0.00035 20.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF2365 PF10157.4 ESS60945.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) HAUS4 PF14735.1 ESS60945.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 PSP1 PF04468.7 ESS60951.1 - 4.4e-26 90.6 0.3 8.6e-26 89.7 0.2 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF3676 PF12429.3 ESS60952.1 - 6.8e-69 231.9 25.0 1.1e-68 231.2 17.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS60952.1 - 1.7e-09 37.4 4.7 2.6e-09 36.7 3.3 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Menin PF05053.8 ESS60952.1 - 3.6 5.6 6.3 4.1 5.4 4.4 1.2 1 0 0 1 1 1 0 Menin BNR_3 PF13859.1 ESS60953.1 - 2.6e-34 118.6 0.3 6.2e-34 117.4 0.0 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60953.1 - 2.5e-10 40.8 2.9 3.4e-10 40.3 0.2 2.3 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF3676 PF12429.3 ESS60953.1 - 8e-06 25.6 4.8 1.3e-05 24.9 3.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Glycos_transf_2 PF00535.21 ESS60955.1 - 9.3e-05 22.1 0.0 0.00019 21.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 ESS60955.1 - 0.049 13.3 0.3 0.24 11.0 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family group 2 BNR_3 PF13859.1 ESS60956.1 - 9.3e-25 87.3 0.0 1.9e-24 86.2 0.0 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60956.1 - 7.9e-15 55.4 0.1 1.4e-14 54.6 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GATase_4 PF13230.1 ESS60956.1 - 0.12 11.0 0.0 0.66 8.6 0.0 1.9 2 0 0 2 2 2 0 Glutamine amidotransferases class-II DGF-1_5 PF11038.3 ESS60960.1 - 1.3e-41 142.6 2.1 2.1e-41 141.9 1.3 1.5 1 1 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS60960.1 - 2.3e-34 117.1 1.1 2.3e-34 117.1 0.8 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS60960.1 - 7.8e-27 93.4 25.0 7.8e-27 93.4 17.4 2.2 2 1 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 MEF2_binding PF09047.5 ESS60960.1 - 0.067 12.8 0.1 0.17 11.5 0.1 1.6 1 0 0 1 1 1 0 MEF2 binding Laminin_G_3 PF13385.1 ESS60961.1 - 5.1e-18 65.8 0.6 1.2e-17 64.6 0.4 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60961.1 - 2.7e-10 39.9 14.8 8.5e-10 38.3 10.3 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal NST1 PF13945.1 ESS60963.1 - 0.023 14.7 9.6 0.033 14.2 6.7 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Shadoo PF14999.1 ESS60965.1 - 0.038 13.8 0.5 0.038 13.8 0.3 1.6 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective RHSP PF07999.6 ESS60966.1 - 5.2e-06 25.3 0.2 9.5e-06 24.4 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein RcsC PF09456.5 ESS60966.1 - 0.015 14.9 0.1 0.12 12.0 0.0 2.3 2 0 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) RHSP PF07999.6 ESS60968.1 - 5.6e-24 84.5 0.9 9.6e-24 83.7 0.6 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF348 PF03990.9 ESS60968.1 - 0.097 12.2 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF348) DGF-1_5 PF11038.3 ESS60969.1 - 5.6e-159 527.6 17.3 5.6e-159 527.6 12.0 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS60969.1 - 5.2e-38 129.2 15.6 1.5e-37 127.8 10.8 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS60969.1 - 1.1e-17 63.7 4.2 4e-17 61.8 2.9 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus BNR_3 PF13859.1 ESS60971.1 - 1.7e-31 109.4 0.2 1.7e-31 109.4 0.1 2.5 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60971.1 - 2.1e-16 60.5 0.7 5.8e-16 59.1 0.5 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60971.1 - 3.5e-09 36.3 14.0 3.5e-09 36.3 9.7 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MRFAP1 PF15155.1 ESS60972.1 - 2 8.7 5.1 3.7 7.9 0.0 2.6 1 1 2 3 3 3 0 MORF4 family-associated protein1 Macoilin PF09726.4 ESS60974.1 - 3.6 5.7 6.1 3.5 5.7 4.3 1.1 1 0 0 1 1 1 0 Transmembrane protein BNR_3 PF13859.1 ESS60977.1 - 8.6e-60 202.4 0.8 1.5e-59 201.6 0.0 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60977.1 - 8.4e-17 61.8 0.2 2.4e-16 60.3 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60977.1 - 1.7e-09 37.3 8.5 1.7e-09 37.3 5.9 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2702 PF10863.3 ESS60978.1 - 0.38 10.4 2.4 0.23 11.1 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2702) Parathyroid PF01279.12 ESS60979.1 - 0.12 12.9 2.6 0.17 12.5 1.8 1.2 1 0 0 1 1 1 0 Parathyroid hormone family Daxx PF03344.10 ESS60980.1 - 0.0033 16.0 29.8 0.0042 15.6 20.6 1.2 1 0 0 1 1 1 1 Daxx Family Ycf1 PF05758.7 ESS60980.1 - 0.25 9.0 13.5 0.32 8.6 9.4 1.1 1 0 0 1 1 1 0 Ycf1 Utp14 PF04615.8 ESS60980.1 - 0.38 8.8 28.5 0.45 8.6 19.7 1.1 1 0 0 1 1 1 0 Utp14 protein BNR_3 PF13859.1 ESS60982.1 - 4e-63 213.3 0.1 6.4e-63 212.6 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS60982.1 - 7.9e-05 22.0 0.1 0.00085 18.7 0.0 2.6 1 1 1 2 2 2 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60982.1 - 0.00019 21.7 0.1 0.00097 19.4 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESS60982.1 - 0.0097 15.5 1.4 1 9.4 0.2 3.4 2 0 0 2 2 2 1 BNR/Asp-box repeat PRT_C PF08372.5 ESS60983.1 - 0.086 12.3 0.2 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal S-methyl_trans PF02574.11 ESS60983.1 - 0.29 10.4 1.1 0.37 10.0 0.2 1.5 2 0 0 2 2 2 0 Homocysteine S-methyltransferase RHSP PF07999.6 ESS60984.1 - 6e-104 348.0 0.0 7.8e-104 347.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS60984.1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain rpo132 PF12415.3 ESS60984.1 - 0.18 10.8 0.0 0.34 9.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase PH PF00169.24 ESS60985.1 - 0.0051 17.0 0.1 0.57 10.4 0.0 3.1 3 1 0 3 3 3 1 PH domain Sp38 PF07354.7 ESS60985.1 - 0.13 10.9 0.4 0.31 9.6 0.1 1.7 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) RHSP PF07999.6 ESS60986.1 - 9.2e-20 70.6 0.2 1e-18 67.1 0.0 1.9 2 0 0 2 2 2 2 Retrotransposon hot spot protein RHSP PF07999.6 ESS60987.1 - 9e-80 268.4 1.9 1.6e-79 267.5 1.3 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS60987.1 - 0.0081 16.3 0.3 2.2 8.4 0.0 2.7 3 0 0 3 3 3 2 AAA domain DUF3676 PF12429.3 ESS60989.1 - 6.9e-106 353.0 42.8 1e-105 352.4 29.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS60989.1 - 2.8e-76 256.5 0.0 7.3e-76 255.1 0.0 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS60989.1 - 2.2e-10 40.1 7.7 2.2e-10 40.1 5.3 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS60991.1 - 1.2e-64 218.3 1.1 5.6e-64 216.1 0.2 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60991.1 - 8e-16 58.6 0.6 8e-16 58.6 0.4 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS60991.1 - 0.00011 22.0 11.6 0.00025 20.8 8.0 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS60993.1 - 1.7e-18 67.0 13.4 1.7e-18 67.0 9.3 4.1 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) Mem_trans PF03547.13 ESS60993.1 - 0.3 9.3 2.0 0.46 8.7 1.4 1.4 1 0 0 1 1 1 0 Membrane transport protein BNR_3 PF13859.1 ESS60995.1 - 1.2e-07 31.0 0.0 1e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS60995.1 - 1.6e-06 28.4 0.1 8e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS61002.1 - 3.2e-09 35.9 0.2 4.9e-09 35.2 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61003.1 - 2.7e-33 115.2 0.0 2.9e-33 115.1 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS61007.1 - 3.4e-109 364.6 6.6 3.4e-109 364.6 4.5 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61007.1 - 8.9e-15 55.2 2.2 2.7e-14 53.7 1.5 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61007.1 - 7.3e-11 41.7 12.9 2e-10 40.3 8.9 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Utp14 PF04615.8 ESS61009.1 - 6.7 4.7 22.9 8.7 4.3 15.8 1.1 1 0 0 1 1 1 0 Utp14 protein DUF1981 PF09324.5 ESS61010.1 - 3.8e-23 80.8 0.1 1.3e-22 79.0 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1981) Sec7 PF01369.15 ESS61011.1 - 5.1e-49 166.5 0.1 1.8e-48 164.7 0.1 2.0 1 1 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESS61011.1 - 2.2e-20 72.7 1.2 5.3e-20 71.5 0.9 1.7 1 1 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF4047 PF13256.1 ESS61011.1 - 0.06 13.2 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) C2 PF00168.25 ESS61012.1 - 1.4e-05 24.8 0.1 2.9e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 C2 domain Reo_sigmaC PF04582.7 ESS61012.1 - 4.4 6.4 9.2 15 4.6 1.5 3.4 3 1 1 4 4 4 0 Reovirus sigma C capsid protein DGF-1_5 PF11038.3 ESS61013.1 - 1.1e-132 441.4 20.1 2.7e-132 440.1 13.9 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61013.1 - 3.9e-42 142.0 0.5 8.7e-42 140.9 0.4 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61014.1 - 8e-43 144.7 16.6 1.8e-42 143.5 11.5 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS61014.1 - 1.5e-05 24.7 0.3 0.018 14.8 0.0 5.2 4 2 1 5 5 5 1 Right handed beta helix region hEGF PF12661.2 ESS61015.1 - 0.026 14.5 1.7 0.064 13.3 1.2 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF cEGF PF12662.2 ESS61015.1 - 0.13 11.8 0.4 0.13 11.8 0.3 2.4 2 1 0 2 2 2 0 Complement Clr-like EGF-like EGF_2 PF07974.8 ESS61015.1 - 1.5 9.0 11.3 8.7 6.6 7.8 2.2 1 1 0 1 1 1 0 EGF-like domain DNA_RNApol_7kD PF03604.8 ESS61017.1 - 1.4 8.4 6.7 5.3 6.5 0.3 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Ribosomal_L37ae PF01780.14 ESS61018.1 - 0.14 12.0 4.0 0.26 11.1 2.8 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family DGF-1_5 PF11038.3 ESS61019.1 - 1.4e-78 263.9 15.6 1.4e-78 263.9 10.8 1.7 2 1 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 RHSP PF07999.6 ESS61020.1 - 4.9e-104 348.3 0.1 4.9e-104 348.3 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS61020.1 - 0.16 11.3 0.2 5.2 6.4 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain DUF605 PF04652.11 ESS61022.1 - 2.8 7.2 17.3 3.4 6.9 12.0 1.1 1 0 0 1 1 1 0 Vta1 like RHSP PF07999.6 ESS61024.1 - 4.3e-74 249.6 1.9 7.1e-74 248.9 1.3 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_29 PF13555.1 ESS61024.1 - 0.01 15.3 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Flavodoxin_1 PF00258.20 ESS61024.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin DUF3920 PF13058.1 ESS61025.1 - 0.022 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3920) THDPS_N_2 PF14805.1 ESS61025.1 - 0.028 14.2 0.1 0.074 12.9 0.1 1.6 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal RHSP PF07999.6 ESS61026.1 - 1.5e-95 320.4 0.1 1.9e-95 320.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61026.1 - 0.00091 19.3 0.0 1.5 8.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 ESS61026.1 - 0.15 11.4 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain RHSP PF07999.6 ESS61027.1 - 2.6e-107 359.1 0.0 4.7e-107 358.3 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein DBINO PF13892.1 ESS61027.1 - 0.0095 15.9 7.5 0.03 14.3 5.2 1.8 1 0 0 1 1 1 1 DNA-binding domain Lenti_VIF_2 PF07401.7 ESS61028.1 - 0.051 12.7 1.5 0.37 9.9 0.2 2.1 1 1 1 2 2 2 0 Bovine Lentivirus VIF protein HAUS4 PF14735.1 ESS61029.1 - 0.04 13.2 0.0 0.058 12.6 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 RHSP PF07999.6 ESS61030.1 - 1.2e-42 146.0 0.0 1.4e-42 145.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.22 ESS61031.1 - 1.5e-21 76.7 0.0 1.8e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS61032.1 - 1.7e-12 47.8 0.0 2.7e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 RNase H EBP50_C-term PF09007.6 ESS61032.1 - 0.04 13.7 0.1 0.14 12.0 0.1 1.9 2 0 0 2 2 2 0 EBP50, C-terminal DAN PF03045.10 ESS61032.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 DAN domain IgG_binding_B PF01378.12 ESS61034.1 - 0.16 11.8 2.4 0.4 10.5 1.6 1.7 1 0 0 1 1 1 0 B domain BNR_3 PF13859.1 ESS61035.1 - 6.6e-19 68.1 0.1 1.6e-18 66.8 0.0 1.7 1 1 1 2 2 2 1 BNR repeat-like domain Utp14 PF04615.8 ESS61036.1 - 0.091 10.9 35.4 0.11 10.6 24.5 1.1 1 0 0 1 1 1 0 Utp14 protein FHIPEP PF00771.15 ESS61036.1 - 0.18 10.1 1.7 0.23 9.7 1.2 1.3 1 0 0 1 1 1 0 FHIPEP family BNR_3 PF13859.1 ESS61037.1 - 5.2e-135 449.4 2.8 5.2e-135 449.4 1.9 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61037.1 - 6.1e-16 59.0 2.3 6.7e-16 58.9 0.1 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61037.1 - 1.5e-08 34.3 10.3 1.5e-08 34.3 7.2 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal ASRT PF07100.6 ESS61040.1 - 0.04 13.6 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer Corona_S2 PF01601.11 ESS61040.1 - 0.086 10.9 3.3 0.11 10.6 2.3 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF2162 PF09930.4 ESS61041.1 - 0.21 10.7 3.7 0.33 10.0 2.5 1.2 1 0 0 1 1 1 0 Predicted transporter (DUF2162) vMSA PF00695.14 ESS61042.1 - 1.7 7.7 4.3 1.9 7.6 2.9 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus RHSP PF07999.6 ESS61043.1 - 1.1e-78 264.7 0.0 1.4e-78 264.4 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61043.1 - 0.11 12.6 0.1 5.1 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain CYSTM PF12734.2 ESS61045.1 - 0.088 12.8 1.0 0.088 12.8 0.7 2.9 2 1 0 2 2 2 0 Cysteine-rich TM module stress tolerance DGF-1_5 PF11038.3 ESS61046.1 - 1.3e-161 536.3 18.6 1.3e-161 536.3 12.9 2.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61046.1 - 9.5e-47 156.8 1.0 9.5e-47 156.8 0.7 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61046.1 - 7.5e-42 141.5 16.3 2.6e-41 139.8 11.3 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS61047.1 - 2.2e-105 352.7 0.2 2.2e-105 352.7 0.2 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein Beta_helix PF13229.1 ESS61051.1 - 2.5e-06 27.3 18.8 0.0073 16.0 0.0 4.9 6 2 0 6 6 6 2 Right handed beta helix region Mito_fiss_reg PF05308.6 ESS61051.1 - 5 6.4 7.1 8.2 5.7 4.9 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator BNR_3 PF13859.1 ESS61052.1 - 5.2e-24 84.8 0.6 5.2e-24 84.8 0.4 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61052.1 - 9.4e-15 55.1 1.8 1.2e-14 54.8 0.4 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61052.1 - 9.8e-08 31.7 5.3 2.5e-07 30.4 3.7 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Phage_integrase PF00589.17 ESS61054.1 - 0.0011 18.6 0.2 0.002 17.8 0.1 1.6 1 1 0 1 1 1 1 Phage integrase family Spc7 PF08317.6 ESS61055.1 - 0.036 12.7 0.7 0.056 12.0 0.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESS61055.1 - 0.08 11.8 4.9 0.12 11.2 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RHSP PF07999.6 ESS61058.1 - 9e-35 120.0 0.0 9.4e-35 120.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Cystatin PF00031.16 ESS61058.1 - 0.27 11.3 1.8 7.7 6.7 0.3 2.5 3 0 0 3 3 3 0 Cystatin domain BNR_3 PF13859.1 ESS61060.1 - 1.7e-64 217.8 5.1 1.9e-64 217.7 3.6 1.0 1 0 0 1 1 1 1 BNR repeat-like domain Topo_Zn_Ribbon PF08272.6 ESS61060.1 - 0.087 12.1 0.3 0.21 10.9 0.2 1.6 1 0 0 1 1 1 0 Topoisomerase I zinc-ribbon-like Lin-8 PF03353.10 ESS61061.1 - 2.7 7.1 7.9 3 7.0 5.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Stm1_N PF09598.5 ESS61062.1 - 1.3 9.8 7.0 0.13 13.0 1.6 1.7 2 0 0 2 2 2 0 Stm1 Mucin PF01456.12 ESS61063.1 - 0.0019 17.9 1.9 0.0019 17.9 1.3 2.0 2 0 0 2 2 2 1 Mucin-like glycoprotein Prok-RING_2 PF14445.1 ESS61067.1 - 0.2 11.6 1.9 0.3 11.0 1.3 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 RNase_H PF00075.19 ESS61069.1 - 0.059 13.7 0.0 0.083 13.2 0.0 1.2 1 0 0 1 1 1 0 RNase H PepSY_TM_1 PF13172.1 ESS61071.1 - 7.1 6.5 7.1 5.2 6.9 0.5 2.5 2 0 0 2 2 2 0 PepSY-associated TM helix Ycf1 PF05758.7 ESS61072.1 - 0.3 8.7 13.4 0.35 8.5 9.3 1.2 1 0 0 1 1 1 0 Ycf1 zf-C2H2_jaz PF12171.3 ESS61073.1 - 0.096 12.8 4.5 3.5 7.8 0.5 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 ESS61073.1 - 0.52 10.6 9.1 1.1 9.6 1.2 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS61073.1 - 1.7 9.1 13.8 2.9 8.4 0.5 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS61073.1 - 1.9 9.0 16.8 0.9 10.0 0.6 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type Peptidase_M8 PF01457.11 ESS61074.1 - 0.0057 15.0 0.0 0.0062 14.9 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin ASRT PF07100.6 ESS61074.1 - 0.032 13.9 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer Corona_S2 PF01601.11 ESS61074.1 - 0.15 10.1 1.6 0.2 9.7 1.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Laminin_G_3 PF13385.1 ESS61076.1 - 1.4e-09 38.4 0.0 4.1e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS61076.1 - 0.0002 20.5 0.5 0.00059 18.9 0.0 1.9 1 1 0 1 1 1 1 BNR repeat-like domain DGF-1_5 PF11038.3 ESS61079.1 - 2.3e-68 230.3 14.0 2.3e-68 230.3 9.7 1.7 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61079.1 - 2.1e-38 130.0 0.9 3.9e-38 129.2 0.6 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus BNR_3 PF13859.1 ESS61080.1 - 2.3e-59 201.0 0.0 2.9e-59 200.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61080.1 - 7.3e-07 28.7 2.5 7.9e-05 22.0 0.6 2.3 1 1 2 3 3 3 3 BNR repeat-like domain BNR PF02012.15 ESS61080.1 - 3.8e-05 22.8 3.5 0.22 11.4 0.1 3.3 2 0 0 2 2 2 2 BNR/Asp-box repeat RHSP PF07999.6 ESS61081.1 - 2.2e-85 286.8 0.0 3e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS61083.1 - 5.4e-05 22.4 0.0 7e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain HDPD PF02924.9 ESS61083.1 - 0.1 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage lambda head decoration protein D RHSP PF07999.6 ESS61085.1 - 9.7e-50 169.4 0.0 1.3e-49 169.0 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_M8 PF01457.11 ESS61087.1 - 2.1e-19 69.3 0.2 2.6e-19 68.9 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESS61087.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Matrixin DUF3810 PF12725.2 ESS61087.1 - 0.062 12.1 0.0 0.08 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Reprolysin_5 PF13688.1 ESS61087.1 - 0.063 13.2 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Astacin PF01400.19 ESS61087.1 - 0.093 12.1 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) BNR_3 PF13859.1 ESS61089.1 - 4.5e-117 390.5 6.9 4.5e-117 390.5 4.8 1.9 1 1 1 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61089.1 - 8.4e-21 74.8 0.5 2.4e-20 73.3 0.3 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61089.1 - 2.7e-10 39.9 7.5 6.1e-10 38.7 5.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2_jaz PF12171.3 ESS61090.1 - 0.044 13.9 4.3 3.6 7.8 0.7 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 ESS61090.1 - 0.1 12.9 5.6 1.7 9.0 1.1 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS61090.1 - 0.22 11.9 11.2 2.2 8.8 1.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESS61090.1 - 0.27 11.3 8.6 0.86 9.7 5.9 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESS61090.1 - 0.94 9.9 16.5 0.4 11.1 1.6 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type MIR PF02815.14 ESS61091.1 - 0.0087 15.6 1.7 0.011 15.2 1.2 1.2 1 0 0 1 1 1 1 MIR domain DUF605 PF04652.11 ESS61091.1 - 0.26 10.6 5.1 0.29 10.4 3.5 1.1 1 0 0 1 1 1 0 Vta1 like RNR_inhib PF08591.5 ESS61091.1 - 3.6 8.5 6.3 10 7.1 0.6 2.1 1 1 1 2 2 2 0 Ribonucleotide reductase inhibitor BNR_3 PF13859.1 ESS61092.1 - 4.4e-130 433.2 6.7 7.9e-130 432.4 4.6 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Galactosyl_T PF01762.16 ESS61094.1 - 9.1e-09 35.1 0.0 0.00088 18.9 0.0 3.5 3 1 0 4 4 4 2 Galactosyltransferase DGF-1_C PF11040.3 ESS61096.1 - 3.3e-49 164.6 1.2 5.1e-49 164.0 0.9 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus PTS_EIIC PF02378.13 ESS61096.1 - 0.0046 15.8 0.1 0.0058 15.5 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase system, EIIC ABC2_membrane_2 PF12679.2 ESS61096.1 - 0.029 13.2 0.7 0.031 13.1 0.5 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Bax1-I PF01027.15 ESS61096.1 - 0.045 13.3 7.9 0.068 12.7 5.5 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Glycos_transf_4 PF00953.16 ESS61096.1 - 2.2 8.0 11.5 3.8 7.2 7.5 1.7 1 1 1 2 2 2 0 Glycosyl transferase family 4 DGF-1_5 PF11038.3 ESS61097.1 - 4.2e-73 245.9 13.5 4.9e-73 245.7 9.4 1.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS61099.1 - 6.2e-41 138.6 16.1 6.2e-41 138.6 11.1 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 GntP_permease PF02447.11 ESS61101.1 - 0.097 11.1 0.4 0.13 10.7 0.3 1.1 1 0 0 1 1 1 0 GntP family permease Daxx PF03344.10 ESS61106.1 - 0.54 8.6 23.0 0.56 8.6 16.0 1.0 1 0 0 1 1 1 0 Daxx Family Orbi_VP6 PF01516.11 ESS61106.1 - 2.3 7.2 15.3 2.5 7.0 10.6 1.0 1 0 0 1 1 1 0 Orbivirus helicase VP6 DUF2890 PF11081.3 ESS61106.1 - 4.8 7.2 16.4 5.5 6.9 11.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Merozoite_SPAM PF07133.6 ESS61106.1 - 7.3 6.4 25.0 6.3 6.6 16.9 1.2 1 1 0 1 1 1 0 Merozoite surface protein (SPAM) BNR_3 PF13859.1 ESS61108.1 - 2.1e-132 440.9 4.1 4.2e-132 439.9 2.8 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61108.1 - 1e-16 61.5 0.2 1e-16 61.5 0.2 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61108.1 - 4.6e-10 39.1 8.9 4.6e-10 39.1 6.1 2.8 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal P12 PF12669.2 ESS61110.1 - 1.3 9.2 6.4 0.15 12.2 1.6 1.6 2 0 0 2 2 2 0 Virus attachment protein p12 family Laminin_G_3 PF13385.1 ESS61111.1 - 7.4e-13 49.0 0.5 1.1e-12 48.4 0.3 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61111.1 - 3.9e-09 36.2 10.7 9.1e-09 35.0 7.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS61113.1 - 1e-105 353.8 0.0 1.5e-105 353.3 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61113.1 - 0.0031 17.6 0.0 4.1 7.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain Sp38 PF07354.7 ESS61114.1 - 0.12 10.9 0.1 0.25 9.9 0.1 1.5 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Ph1570 PF09638.5 ESS61115.1 - 0.005 16.6 0.1 0.028 14.2 0.0 2.2 2 1 0 2 2 2 1 Ph1570 protein MAP7 PF05672.6 ESS61115.1 - 0.043 13.1 27.6 0.086 12.2 19.1 1.5 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family HSP70 PF00012.15 ESS61115.1 - 0.61 7.9 9.2 0.87 7.4 6.4 1.1 1 0 0 1 1 1 0 Hsp70 protein Macoilin PF09726.4 ESS61115.1 - 4.3 5.4 12.1 5.8 5.0 8.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Asp-B-Hydro_N PF05279.6 ESS61115.1 - 9.7 5.9 14.3 14 5.4 9.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BNR_3 PF13859.1 ESS61117.1 - 9.3e-129 428.9 4.7 9.3e-129 428.9 3.3 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61117.1 - 8.8e-18 65.0 1.1 1.6e-17 64.2 0.2 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS61125.1 - 1.7e-67 227.9 0.2 2.4e-67 227.4 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61125.1 - 0.02 15.0 0.2 1.8 8.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain FYVE PF01363.16 ESS61129.1 - 0.14 12.0 1.7 0.33 10.8 1.2 1.6 1 0 0 1 1 1 0 FYVE zinc finger DUF3747 PF12565.3 ESS61130.1 - 0.044 12.8 0.0 0.046 12.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3747) cEGF PF12662.2 ESS61134.1 - 3.3 7.4 14.8 0.028 14.0 0.8 3.6 3 0 0 3 3 3 0 Complement Clr-like EGF-like DGF-1_5 PF11038.3 ESS61136.1 - 2e-144 479.9 18.0 3.1e-144 479.2 12.4 1.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61136.1 - 8.7e-41 137.7 1.4 2.1e-40 136.4 1.0 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF3676 PF12429.3 ESS61137.1 - 2.1e-110 367.8 40.1 2.8e-110 367.4 27.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS61137.1 - 5.4e-10 38.9 3.5 1.1e-09 38.0 2.5 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS61138.1 - 4.1e-23 81.7 12.9 6.4e-21 74.6 2.5 2.4 2 0 0 2 2 2 2 Mucin-like glycoprotein DUF3747 PF12565.3 ESS61139.1 - 0.011 14.8 0.0 0.013 14.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3747) zf-C2H2_4 PF13894.1 ESS61140.1 - 0.59 10.5 4.9 1.5 9.3 1.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger BNR_3 PF13859.1 ESS61141.1 - 9.4e-135 448.6 3.0 1.3e-134 448.1 2.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS61143.1 - 3.2e-39 133.9 53.1 1.5e-26 92.8 25.1 2.1 1 1 1 2 2 2 2 Mucin-like glycoprotein BSP_II PF05432.6 ESS61143.1 - 0.54 9.4 12.3 1 8.5 8.5 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) ARF7EP_C PF14949.1 ESS61144.1 - 0.011 16.1 1.6 0.018 15.4 1.1 1.3 1 0 0 1 1 1 0 ARF7 effector protein C-terminus RHSP PF07999.6 ESS61145.1 - 2.9e-89 299.6 3.3 1.4e-82 277.6 1.1 2.6 1 1 1 2 2 2 2 Retrotransposon hot spot protein RHSP PF07999.6 ESS61147.1 - 3e-105 352.3 0.9 5.5e-105 351.4 0.6 1.5 1 0 0 1 1 1 1 Retrotransposon hot spot protein DAP3 PF10236.4 ESS61147.1 - 0.045 12.6 0.0 1.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF2448 PF10476.4 ESS61149.1 - 0.012 15.1 0.1 0.016 14.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) WD40 PF00400.27 ESS61151.1 - 9.6e-05 22.1 0.1 0.47 10.4 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat EF-hand_8 PF13833.1 ESS61151.1 - 0.0029 17.1 0.0 0.012 15.2 0.0 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 ESS61151.1 - 0.0037 17.3 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair V-ATPase_G PF03179.10 ESS61153.1 - 2e-18 66.6 13.1 2e-18 66.6 9.1 1.4 2 0 0 2 2 2 1 Vacuolar (H+)-ATPase G subunit MalF_P2 PF14785.1 ESS61153.1 - 0.054 13.3 3.5 0.068 13.0 2.4 1.1 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain DUF3154 PF11351.3 ESS61153.1 - 0.9 9.2 5.5 0.85 9.3 2.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3154) Glyco_transf_8 PF01501.15 ESS61154.1 - 4e-14 52.5 0.0 1.1e-13 51.0 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 ESS61154.1 - 0.02 14.2 0.1 0.034 13.4 0.1 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative DUF2270 PF10028.4 ESS61157.1 - 0.052 13.0 0.1 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2270) SCIMP PF15050.1 ESS61158.1 - 0.03 14.1 2.7 0.18 11.6 0.7 2.4 2 1 0 2 2 2 0 SCIMP protein Mucin PF01456.12 ESS61158.1 - 4.1 7.1 22.3 31 4.3 14.5 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS61159.1 - 1.9e-136 454.1 12.3 4.1e-136 453.0 5.4 2.4 2 0 0 2 2 2 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61159.1 - 1.5e-18 67.4 3.7 5e-18 65.8 0.8 2.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61159.1 - 1.1e-09 38.0 12.4 3e-09 36.5 8.6 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS61159.1 - 0.018 15.0 0.3 0.047 13.7 0.2 1.7 1 0 0 1 1 1 0 Laminin G domain Mucin PF01456.12 ESS61161.1 - 1e-25 90.1 26.7 1.1e-25 90.0 18.5 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.6 ESS61161.1 - 0.53 8.1 23.1 0.58 8.0 16.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4658 PF15555.1 ESS61161.1 - 1.5 8.7 3.6 2.9 7.7 2.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) MGC-24 PF05283.6 ESS61161.1 - 7.2 6.3 16.6 7 6.3 11.5 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) RHSP PF07999.6 ESS61165.1 - 4.3e-74 249.6 0.1 4.9e-74 249.4 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3502 PF12010.3 ESS61165.1 - 0.0029 17.5 0.1 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) DUF348 PF03990.9 ESS61166.1 - 0.049 13.2 0.1 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF348) DUF427 PF04248.7 ESS61166.1 - 0.079 12.6 0.0 4.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF427) SecE PF00584.15 ESS61168.1 - 0.51 9.9 2.9 0.78 9.3 2.0 1.3 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex BNR_3 PF13859.1 ESS61169.1 - 1.1e-58 198.7 2.4 1.4e-58 198.3 1.6 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS61170.1 - 4.2e-63 213.2 2.0 5.1e-63 212.9 0.5 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61170.1 - 2e-16 60.5 0.4 5.3e-16 59.2 0.3 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61170.1 - 8.7e-11 41.4 11.1 1.8e-10 40.4 7.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS61172.1 - 1.3e-07 31.9 0.0 1.7e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Daxx PF03344.10 ESS61173.1 - 0.1 11.0 19.5 0.13 10.6 13.5 1.1 1 0 0 1 1 1 0 Daxx Family Hid1 PF12722.2 ESS61173.1 - 4.2 4.9 13.9 5.1 4.6 9.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Utp14 PF04615.8 ESS61173.1 - 7 4.6 24.2 8.6 4.3 16.8 1.0 1 0 0 1 1 1 0 Utp14 protein BNR_3 PF13859.1 ESS61174.1 - 3.3e-131 436.9 1.9 6.2e-131 436.0 1.3 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61174.1 - 8.3e-16 58.6 3.4 2.4e-15 57.1 2.3 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61174.1 - 4.9e-07 29.5 7.6 1.4e-06 28.0 5.3 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS61175.1 - 1.8e-94 316.8 0.0 3.1e-94 316.0 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3487 PF11990.3 ESS61176.1 - 1.1 8.6 7.8 1.5 8.2 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) BNR_3 PF13859.1 ESS61177.1 - 6.3e-56 189.7 0.2 7.9e-56 189.3 0.1 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61177.1 - 0.00017 21.0 0.1 0.00056 19.2 0.1 1.9 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS61177.1 - 0.013 15.2 5.1 0.57 10.2 0.2 3.3 3 0 0 3 3 3 0 BNR/Asp-box repeat Laminin_G_3 PF13385.1 ESS61178.1 - 1.2e-10 41.9 0.0 1.3e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EF1G PF00647.14 ESS61179.1 - 5.3e-06 26.0 0.0 7.9e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain Laminin_G_3 PF13385.1 ESS61181.1 - 1.1e-17 64.7 0.3 1.6e-17 64.1 0.2 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Mucin PF01456.12 ESS61183.1 - 3.6e-07 30.0 46.1 0.024 14.4 32.0 3.4 1 1 0 1 1 1 1 Mucin-like glycoprotein UPF0257 PF06788.8 ESS61183.1 - 0.042 13.0 0.3 0.067 12.4 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0257) CCDC14 PF15254.1 ESS61184.1 - 1.2 7.4 6.0 1.4 7.2 4.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Mito_fiss_reg PF05308.6 ESS61186.1 - 0.11 11.8 1.8 0.18 11.1 1.3 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator BNR_3 PF13859.1 ESS61189.1 - 2.4e-64 217.3 2.0 2.8e-64 217.1 0.5 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61189.1 - 8.2e-12 45.6 0.5 1.5e-11 44.7 0.4 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Thyroglobulin_1 PF00086.13 ESS61190.1 - 0.063 12.6 2.1 0.065 12.5 0.8 1.6 1 1 1 2 2 2 0 Thyroglobulin type-1 repeat zf-C4pol PF14260.1 ESS61190.1 - 5 7.1 7.3 8 6.5 5.0 1.5 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta DUF320 PF03777.8 ESS61192.1 - 0.026 14.2 0.5 0.052 13.3 0.3 1.5 1 0 0 1 1 1 0 Small secreted domain (DUF320) BNR_3 PF13859.1 ESS61193.1 - 2.8e-131 437.1 5.3 2.8e-131 437.1 3.7 2.1 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61193.1 - 5.6e-15 55.9 0.3 7.5e-14 52.2 0.1 2.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61193.1 - 2.8e-07 30.2 10.8 2.8e-07 30.2 7.5 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal FA PF08736.6 ESS61194.1 - 1.1 9.0 4.3 0.62 9.9 0.7 2.0 2 0 0 2 2 2 0 FERM adjacent (FA) Mucin PF01456.12 ESS61195.1 - 0.043 13.6 7.0 0.05 13.3 4.9 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein CCER1 PF15482.1 ESS61195.1 - 1 8.9 4.9 1.2 8.7 3.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 Apc15p PF05841.6 ESS61198.1 - 3.4 8.4 9.1 0.8 10.4 1.2 2.1 2 0 0 2 2 2 0 Apc15p protein Phage_integrase PF00589.17 ESS61200.1 - 0.0066 16.1 1.0 0.019 14.6 0.5 2.1 2 1 0 2 2 2 1 Phage integrase family RCR PF12273.3 ESS61204.1 - 0.095 13.2 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Enterotoxin_HS1 PF08090.6 ESS61204.1 - 2.7 7.7 6.7 5 6.9 4.7 1.5 1 1 0 1 1 1 0 Heat stable E.coli enterotoxin 1 DUF3676 PF12429.3 ESS61206.1 - 6.7e-114 379.2 51.5 9.4e-114 378.7 35.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS61206.1 - 1.4e-80 270.7 0.1 1.4e-80 270.7 0.1 2.8 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61206.1 - 6.3e-11 41.9 4.5 6.3e-11 41.9 3.2 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS61207.1 - 2e-23 82.7 0.6 2e-23 82.7 0.4 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein Retinal PF15449.1 ESS61209.1 - 0.4 8.2 19.2 0.53 7.8 13.3 1.1 1 0 0 1 1 1 0 Retinal protein DUF605 PF04652.11 ESS61209.1 - 0.53 9.6 10.1 0.67 9.2 7.0 1.1 1 0 0 1 1 1 0 Vta1 like RNase_H PF00075.19 ESS61210.1 - 2.3e-08 34.4 0.0 3.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_jaz PF12171.3 ESS61210.1 - 0.2 11.8 5.0 6.6 7.0 1.0 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 ESS61210.1 - 1.6 8.9 8.0 6.7 6.9 5.6 2.1 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 ESS61210.1 - 6.1 7.4 17.6 4.1 7.9 2.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS61210.1 - 6.7 7.2 22.6 1 9.8 1.6 3.6 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESS61210.1 - 7.8 6.9 12.9 0.9 9.9 1.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain DUF4407 PF14362.1 ESS61212.1 - 0.026 13.4 3.8 0.047 12.6 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IFT57 PF10498.4 ESS61212.1 - 0.31 9.7 1.7 0.46 9.1 1.2 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Pkinase PF00069.20 ESS61216.1 - 1.2e-66 224.5 0.0 1.6e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS61216.1 - 5.8e-50 169.7 0.0 9.4e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MORN PF02493.15 ESS61216.1 - 1.8e-42 140.5 41.4 4.2e-08 32.4 0.2 8.6 8 0 0 8 8 8 8 MORN repeat Kinase-like PF14531.1 ESS61216.1 - 0.00013 21.0 0.0 0.00044 19.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like SMC_N PF02463.14 ESS61217.1 - 5.9e-60 202.2 0.0 8.1e-59 198.5 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESS61217.1 - 3.2e-16 59.3 0.1 1.2e-15 57.5 0.1 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 ESS61217.1 - 1.2e-15 58.2 0.2 6.8e-08 32.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.1 ESS61217.1 - 1.9e-09 38.1 21.8 1.9e-09 38.1 15.1 5.2 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESS61217.1 - 0.00016 21.1 0.0 0.00035 20.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESS61217.1 - 0.001 19.3 14.6 0.075 13.3 0.9 5.5 4 2 0 4 4 4 2 ABC transporter AAA_15 PF13175.1 ESS61217.1 - 0.0032 16.5 5.2 0.02 13.9 0.0 3.3 4 0 0 4 4 4 1 AAA ATPase domain Baculo_PEP_C PF04513.7 ESS61217.1 - 0.0039 17.0 2.3 0.062 13.1 0.6 3.3 3 0 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ESS61217.1 - 0.071 12.9 8.0 0.32 10.8 2.3 3.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TPR_11 PF13414.1 ESS61218.1 - 1.6e-22 78.8 15.9 8.9e-09 34.8 1.2 6.6 4 1 4 8 8 8 5 TPR repeat TPR_2 PF07719.12 ESS61218.1 - 2.6e-16 58.1 17.8 2.1e-06 27.2 0.2 9.2 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS61218.1 - 1.6e-15 57.2 0.1 4.7e-05 23.6 0.0 6.3 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS61218.1 - 8.3e-15 53.9 3.9 0.0016 18.8 0.0 7.5 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS61218.1 - 5.1e-14 51.2 0.8 0.0075 16.3 0.0 7.8 7 2 1 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS61218.1 - 8.6e-14 50.4 15.1 3.7e-06 26.3 0.4 8.7 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESS61218.1 - 2.3e-12 47.1 11.2 0.00017 22.1 0.2 6.3 4 1 3 7 7 7 5 Tetratricopeptide repeat Apc3 PF12895.2 ESS61218.1 - 2.4e-12 46.8 13.2 2.8e-08 33.7 0.2 6.0 5 1 4 9 9 9 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 ESS61218.1 - 2.4e-10 40.1 23.7 0.00065 19.5 0.2 7.3 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESS61218.1 - 2.1e-08 33.3 3.8 0.00016 21.1 0.3 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS61218.1 - 2.5e-07 30.4 8.3 1.7e-05 24.5 0.3 4.6 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS61218.1 - 8.3e-06 25.2 2.6 0.011 15.4 0.0 5.4 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS61218.1 - 2.8e-05 24.2 5.6 0.14 12.7 0.1 5.9 6 0 0 6 6 5 1 Tetratricopeptide repeat BTAD PF03704.12 ESS61218.1 - 0.00046 20.5 9.0 0.0037 17.5 0.8 3.4 3 1 0 3 3 3 1 Bacterial transcriptional activator domain TPR_20 PF14561.1 ESS61218.1 - 0.0032 17.5 0.1 0.017 15.1 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.9 ESS61218.1 - 0.016 14.3 0.0 1.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Coatomer epsilon subunit TPR_3 PF07720.7 ESS61218.1 - 0.024 14.4 0.0 1.2 8.9 0.0 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.3 ESS61218.1 - 0.03 13.0 0.2 0.2 10.3 0.0 1.9 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 TPR_4 PF07721.9 ESS61218.1 - 0.45 11.1 16.6 0.4 11.2 0.7 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS61218.1 - 1.3 9.0 11.5 0.33 10.9 0.1 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat Metallophos PF00149.23 ESS61219.1 - 0.0014 18.0 0.4 0.0073 15.7 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Tctex-1 PF03645.8 ESS61221.1 - 1.1e-23 82.9 0.1 1.2e-23 82.8 0.1 1.0 1 0 0 1 1 1 1 Tctex-1 family DUF4537 PF15057.1 ESS61227.1 - 0.021 14.5 0.0 11 5.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) DUF4479 PF14794.1 ESS61227.1 - 0.041 13.4 0.0 12 5.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) DGF-1_C PF11040.3 ESS61228.1 - 7.8e-48 160.2 0.7 1.4e-47 159.4 0.5 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS61228.1 - 4.1e-21 75.4 3.7 4.1e-21 75.4 2.6 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 ABC2_membrane_2 PF12679.2 ESS61228.1 - 0.43 9.3 3.7 0.098 11.5 0.5 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein Orbi_NS3 PF01616.11 ESS61228.1 - 1.8 7.5 5.0 0.48 9.3 0.1 2.2 2 1 0 2 2 2 0 Orbivirus NS3 Mucin PF01456.12 ESS61229.1 - 1e-29 103.1 67.2 6e-27 94.1 46.6 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS61229.1 - 0.036 14.6 4.8 0.04 14.4 3.3 1.1 1 0 0 1 1 1 0 FAM163 family Shisa PF13908.1 ESS61229.1 - 0.1 12.7 9.3 0.13 12.3 6.5 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1675 PF07897.6 ESS61229.1 - 0.18 11.6 3.2 0.22 11.3 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DUF2360 PF10152.4 ESS61229.1 - 0.25 11.6 4.3 0.29 11.4 2.9 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) LAT PF15234.1 ESS61229.1 - 0.42 10.0 9.0 0.63 9.4 6.3 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells Pex14_N PF04695.8 ESS61229.1 - 0.61 10.1 6.6 0.7 9.9 4.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAP PF07174.6 ESS61229.1 - 1.2 8.3 10.8 1.3 8.2 7.5 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) MCPVI PF02993.9 ESS61229.1 - 5.4 7.0 7.4 6.4 6.8 5.1 1.0 1 0 0 1 1 1 0 Minor capsid protein VI PRCC PF10253.4 ESS61229.1 - 9.5 6.8 8.5 11 6.6 5.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting BNR_3 PF13859.1 ESS61230.1 - 1.5e-100 336.2 3.5 1.8e-100 336.0 2.4 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61230.1 - 0.0004 19.7 0.3 0.043 13.1 0.0 1.6 1 1 1 2 2 2 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61231.1 - 0.0035 17.5 0.4 0.0039 17.4 0.3 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DGF-1_5 PF11038.3 ESS61237.1 - 1.3e-46 159.0 12.5 1.3e-46 159.0 8.6 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61237.1 - 1e-39 134.2 1.2 2e-39 133.3 0.8 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus BNR_3 PF13859.1 ESS61240.1 - 1.4e-132 441.4 6.5 2.3e-132 440.7 4.5 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61240.1 - 1.4e-21 77.4 0.3 4.1e-21 75.8 0.2 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61240.1 - 8.2e-11 41.5 11.1 2.2e-10 40.1 7.7 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MIP-T3 PF10243.4 ESS61241.1 - 0.0026 16.2 22.8 0.0031 16.0 15.8 1.0 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Mucin PF01456.12 ESS61242.1 - 4e-32 110.9 71.6 1.9e-31 108.7 49.6 1.8 1 1 0 1 1 1 1 Mucin-like glycoprotein MGC-24 PF05283.6 ESS61242.1 - 0.0087 15.8 29.5 0.01 15.6 20.4 1.2 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24) FAM163 PF15069.1 ESS61242.1 - 0.012 16.1 7.8 0.014 16.0 5.4 1.2 1 0 0 1 1 1 0 FAM163 family PROL5-SMR PF15621.1 ESS61242.1 - 0.062 13.7 3.0 0.074 13.4 2.1 1.1 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family Shisa PF13908.1 ESS61242.1 - 0.072 13.2 10.7 0.11 12.7 7.4 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS61242.1 - 0.2 11.9 5.6 0.25 11.6 3.9 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) MCPVI PF02993.9 ESS61242.1 - 1.1 9.3 9.1 1.3 9.1 6.3 1.0 1 0 0 1 1 1 0 Minor capsid protein VI DUF2413 PF10310.4 ESS61242.1 - 2.9 6.6 5.8 3.1 6.4 4.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) PIH1 PF08190.7 ESS61242.1 - 4.7 6.5 8.8 5.2 6.4 6.1 1.0 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 PRCC PF10253.4 ESS61242.1 - 5.1 7.7 10.6 6.3 7.4 7.4 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Golgin_A5 PF09787.4 ESS61242.1 - 5.8 5.3 7.9 6.6 5.1 5.5 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 TFIIA PF03153.8 ESS61242.1 - 8.4 6.1 8.7 9.4 6.0 6.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RHSP PF07999.6 ESS61246.1 - 6.5e-105 351.2 1.4 1.8e-104 349.8 0.0 1.9 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61246.1 - 0.0023 18.0 0.0 4.8 7.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain OKR_DC_1_N PF03709.10 ESS61247.1 - 0.029 14.4 2.0 0.058 13.4 0.3 2.2 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain UPF0697 PF15117.1 ESS61247.1 - 7.6 6.3 6.4 8.6 6.2 0.6 2.3 1 1 1 2 2 2 0 Uncharacterised protein family UPF0697 RHSP PF07999.6 ESS61249.1 - 8.6e-107 357.4 4.8 2.3e-106 356.0 3.3 1.7 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF427 PF04248.7 ESS61249.1 - 0.046 13.3 0.1 1 9.0 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF427) BNR_3 PF13859.1 ESS61252.1 - 7.3e-103 343.8 4.4 9.5e-103 343.4 3.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61252.1 - 5.3e-06 25.9 0.4 8.5e-06 25.2 0.3 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS61252.1 - 0.017 14.9 0.6 0.037 13.8 0.4 1.6 1 1 0 1 1 1 0 Mucin-like glycoprotein Laminin_G_3 PF13385.1 ESS61253.1 - 4.6e-18 65.9 0.4 1.1e-17 64.7 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61253.1 - 1.1e-07 31.6 11.7 2.3e-07 30.5 8.1 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_2 PF02210.19 ESS61253.1 - 0.049 13.6 0.2 0.16 11.9 0.1 1.9 1 1 0 1 1 1 0 Laminin G domain KASH PF10541.4 ESS61254.1 - 1.4 8.8 5.0 1.8 8.4 1.2 2.0 2 0 0 2 2 2 0 Nuclear envelope localisation domain DUF4131 PF13567.1 ESS61254.1 - 1.7 8.0 4.8 2 7.8 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3446 PF11928.3 ESS61257.1 - 0.086 13.0 1.4 0.11 12.7 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) Perm-CXXC PF15629.1 ESS61260.1 - 0.014 15.3 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 Permuted single zf-CXXC unit MBOAT PF03062.14 ESS61261.1 - 1.8e-23 83.2 17.9 1.8e-23 83.2 12.4 1.4 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family PAP2 PF01569.16 ESS61262.1 - 2.7e-22 78.8 0.6 2.7e-22 78.8 0.4 2.2 1 1 1 2 2 2 1 PAP2 superfamily Mtp PF03821.11 ESS61262.1 - 0.0098 15.3 2.3 0.022 14.1 1.6 1.5 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter PDZ_2 PF13180.1 ESS61263.1 - 5.9e-06 26.0 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 ESS61263.1 - 0.0031 17.6 0.0 0.0068 16.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 ESS61263.1 - 0.13 12.0 0.0 0.4 10.5 0.0 1.8 2 0 0 2 2 2 0 Tricorn protease PDZ domain Cation_efflux PF01545.16 ESS61264.1 - 3.5e-30 105.0 8.7 3.8e-29 101.6 6.0 2.0 1 1 0 1 1 1 1 Cation efflux family Zip PF02535.17 ESS61264.1 - 0.0087 15.1 4.0 0.025 13.5 1.2 2.2 2 0 0 2 2 2 1 ZIP Zinc transporter Lipase_3 PF01764.20 ESS61265.1 - 6.1e-20 71.2 0.0 1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 ESS61265.1 - 0.00089 19.1 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS61265.1 - 0.0027 17.4 0.0 0.0044 16.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FYVE PF01363.16 ESS61265.1 - 0.0028 17.5 23.7 0.0028 17.5 16.5 2.6 2 1 1 3 3 3 1 FYVE zinc finger PGAP1 PF07819.8 ESS61265.1 - 0.015 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.9 ESS61265.1 - 0.033 13.4 0.0 0.06 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Thioesterase PF00975.15 ESS61265.1 - 0.076 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain DUF2974 PF11187.3 ESS61265.1 - 0.1 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) RHSP PF07999.6 ESS61267.1 - 1.8e-68 231.1 0.4 2.3e-68 230.8 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61267.1 - 0.12 12.4 0.3 1.6 8.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain IFT57 PF10498.4 ESS61268.1 - 0.026 13.2 2.6 0.04 12.6 1.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.6 ESS61268.1 - 0.056 12.1 1.3 0.092 11.3 0.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.9 ESS61268.1 - 0.07 12.7 1.6 0.13 11.8 1.1 1.4 1 0 0 1 1 1 0 IncA protein DUF4407 PF14362.1 ESS61268.1 - 0.17 10.8 7.2 0.27 10.1 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RHSP PF07999.6 ESS61270.1 - 5.2e-118 394.4 0.1 7.4e-118 393.8 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein MAP7 PF05672.6 ESS61270.1 - 0.021 14.2 27.5 0.037 13.3 19.1 1.3 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF348 PF03990.9 ESS61270.1 - 0.1 12.1 0.0 12 5.5 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF348) HSP70 PF00012.15 ESS61270.1 - 2.1 6.1 9.0 3.2 5.5 6.2 1.1 1 0 0 1 1 1 0 Hsp70 protein Met_10 PF02475.11 ESS61273.1 - 7.6e-33 113.7 0.0 1.1e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.8 ESS61273.1 - 0.0012 18.0 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESS61273.1 - 0.0025 17.8 0.0 0.0045 17.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain TRM PF02005.11 ESS61273.1 - 0.015 14.2 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase UPF0020 PF01170.13 ESS61273.1 - 0.061 12.9 0.0 0.094 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Pkinase PF00069.20 ESS61274.1 - 2.8e-64 216.7 0.0 4.2e-64 216.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS61274.1 - 9.2e-44 149.4 0.0 1.3e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS61274.1 - 0.011 14.7 0.0 0.027 13.4 0.0 1.6 1 1 0 1 1 1 0 Kinase-like GRASP55_65 PF04495.9 ESS61275.1 - 8.9e-05 22.5 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ_2 PF13180.1 ESS61275.1 - 0.023 14.5 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PPR PF01535.15 ESS61276.1 - 0.12 12.4 0.4 0.64 10.1 0.1 2.4 2 0 0 2 2 2 0 PPR repeat Radical_SAM PF04055.16 ESS61277.1 - 3.6e-15 56.5 0.0 1.1e-14 54.9 0.0 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 ESS61277.1 - 1.4e-08 34.6 0.3 2.3e-06 27.5 0.1 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESS61277.1 - 0.022 14.8 0.7 0.072 13.2 0.1 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DSPc PF00782.15 ESS61278.1 - 3.3e-08 33.1 0.0 5.2e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS61278.1 - 3.9e-07 29.6 0.0 1.3e-06 27.9 0.0 1.7 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESS61278.1 - 0.083 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.7 ESS61278.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) DUF2719 PF10891.3 ESS61278.1 - 0.12 12.0 0.1 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) DUF605 PF04652.11 ESS61280.1 - 0.18 11.1 11.6 0.24 10.7 8.0 1.3 1 0 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS61281.1 - 3.1e-131 437.0 6.7 3.5e-131 436.8 4.1 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61281.1 - 9.6e-18 64.9 0.6 2.1e-17 63.7 0.4 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61281.1 - 2.6e-09 36.7 11.2 2.6e-09 36.7 7.8 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS61282.1 - 1.4e-38 131.9 39.0 2.6e-38 130.9 27.0 1.5 1 1 0 1 1 1 1 Mucin-like glycoprotein ZU5 PF00791.15 ESS61283.1 - 0.11 12.2 1.1 0.12 12.0 0.6 1.3 1 1 0 1 1 1 0 ZU5 domain PhnH PF05845.7 ESS61285.1 - 0.019 14.4 0.2 0.031 13.7 0.2 1.3 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnH) Peptidase_M8 PF01457.11 ESS61287.1 - 2e-107 359.6 8.0 1.7e-106 356.6 5.5 1.9 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS61287.1 - 9.4e-10 38.1 8.3 9.4e-10 38.1 5.7 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS61287.1 - 0.053 13.2 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 Matrixin BNR_3 PF13859.1 ESS61292.1 - 3.4e-132 440.2 5.7 3.4e-132 440.2 3.9 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61292.1 - 3.9e-15 56.4 0.1 1.4e-14 54.6 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61292.1 - 1.4e-09 37.5 12.3 3.9e-09 36.2 8.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Na_trans_assoc PF06512.8 ESS61292.1 - 0.51 10.2 4.1 1.3 8.9 2.9 1.7 1 0 0 1 1 1 0 Sodium ion transport-associated Transglut_core PF01841.14 ESS61293.1 - 0.07 13.3 0.1 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 Transglutaminase-like superfamily BNR_3 PF13859.1 ESS61296.1 - 1e-134 448.5 13.3 2.7e-134 447.0 6.4 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61296.1 - 1e-20 74.5 1.9 2e-20 73.5 0.6 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61296.1 - 4.9e-11 42.2 5.3 1.3e-10 40.9 3.7 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS61296.1 - 3e-05 23.4 0.0 7.2e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 BNR repeat-like domain zf-C2H2_4 PF13894.1 ESS61300.1 - 0.97 9.9 7.9 4.6 7.8 1.1 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger BNR_3 PF13859.1 ESS61304.1 - 1.6e-129 431.4 7.3 2.5e-129 430.8 5.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61304.1 - 6e-10 38.8 13.5 6e-10 38.8 9.4 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2_jaz PF12171.3 ESS61305.1 - 0.018 15.1 3.7 1.9 8.7 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 ESS61305.1 - 0.079 13.2 7.0 0.57 10.5 1.2 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESS61305.1 - 0.11 12.8 11.5 2.3 8.7 1.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS61305.1 - 0.28 11.5 16.9 0.4 11.1 1.6 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESS61305.1 - 0.51 10.5 7.8 1.6 8.8 5.4 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 ESS61305.1 - 2.9 7.9 5.5 3.3 7.7 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.22 ESS61306.1 - 1.4e-31 109.4 0.0 2.6e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS61306.1 - 3.2e-13 50.1 0.0 6.1e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 RNase H EBP50_C-term PF09007.6 ESS61306.1 - 0.092 12.6 0.1 0.3 10.9 0.1 1.9 1 0 0 1 1 1 0 EBP50, C-terminal ERF PF04404.7 ESS61306.1 - 0.14 11.6 0.0 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 ERF superfamily DGF-1_5 PF11038.3 ESS61307.1 - 2.6e-156 518.8 17.7 2.6e-156 518.8 12.3 3.0 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61307.1 - 1.8e-36 123.9 2.6 1.8e-36 123.9 1.8 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61307.1 - 9.9e-34 115.5 19.0 9.9e-34 115.5 13.2 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS61308.1 - 1.8e-47 161.9 1.0 3.1e-47 161.1 0.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61308.1 - 1.7e-11 44.6 0.0 7.2e-11 42.5 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS61308.1 - 4.5e-05 22.8 0.3 0.0074 15.6 0.0 2.4 2 0 0 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS61308.1 - 0.00016 20.9 5.1 0.24 11.3 0.1 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_3 PF13859.1 ESS61311.1 - 5.6e-121 403.3 5.1 9.5e-121 402.6 3.5 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61311.1 - 2e-15 57.3 1.4 2e-15 57.3 0.9 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61311.1 - 5.1e-09 35.8 10.6 9.6e-09 34.9 7.4 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS61312.1 - 9.2e-25 87.1 12.9 9.2e-25 87.1 8.9 4.5 1 1 4 5 5 5 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS61313.1 - 0.0012 18.0 0.1 0.0015 17.6 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61317.1 - 1.3e-12 48.2 0.5 1.3e-12 48.2 0.3 2.1 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61317.1 - 4.3e-09 36.0 9.4 1.3e-08 34.5 6.5 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61318.1 - 2.3e-102 342.2 7.0 2.8e-102 341.9 4.9 1.1 1 0 0 1 1 1 1 BNR repeat-like domain YqzM PF14141.1 ESS61319.1 - 0.082 12.6 2.4 0.15 11.8 1.6 1.4 1 0 0 1 1 1 0 YqzM-like protein Gastrin PF00918.12 ESS61321.1 - 0.04 14.7 1.2 0.083 13.7 0.8 1.5 1 0 0 1 1 1 0 Gastrin/cholecystokinin family BNR_3 PF13859.1 ESS61322.1 - 1.2e-29 103.3 0.1 1.2e-29 103.3 0.1 1.5 2 0 0 2 2 2 1 BNR repeat-like domain H-K_ATPase_N PF09040.6 ESS61322.1 - 0.29 11.2 2.8 1.4 9.0 0.0 2.7 3 0 0 3 3 3 0 Gastric H+/K+-ATPase, N terminal domain Laminin_G_3 PF13385.1 ESS61323.1 - 8.4e-12 45.6 0.1 8.4e-12 45.6 0.1 2.0 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61323.1 - 2.1e-10 40.2 9.3 5.1e-10 39.0 6.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RVT_1 PF00078.22 ESS61325.1 - 6.5e-21 74.6 0.0 8.3e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESS61327.1 - 5.8e-17 61.3 0.0 1e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS61327.1 - 1.1e-14 54.9 0.0 1.8e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Brix PF04427.13 ESS61328.1 - 2.6e-36 125.1 0.0 3.8e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 Brix domain LRR_6 PF13516.1 ESS61329.1 - 2.5e-05 23.8 20.0 0.16 12.1 0.2 8.5 10 0 0 10 10 10 3 Leucine Rich repeat LRR_4 PF12799.2 ESS61329.1 - 4e-05 23.1 9.5 0.031 13.9 0.0 6.2 5 1 3 8 8 7 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS61329.1 - 0.0089 15.7 6.8 15 5.4 0.2 5.3 3 2 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 ESS61329.1 - 0.011 15.6 20.9 60 4.2 0.0 9.1 9 1 0 9 9 9 0 Leucine Rich Repeat DUF717 PF05338.7 ESS61329.1 - 0.074 13.0 0.2 8.7 6.3 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF717) LRR_7 PF13504.1 ESS61329.1 - 0.17 12.1 17.7 18 6.0 0.3 8.5 9 0 0 9 9 9 0 Leucine rich repeat MIT PF04212.13 ESS61330.1 - 0.0083 15.9 1.3 0.063 13.1 0.1 2.6 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain CTP_transf_1 PF01148.15 ESS61331.1 - 8.4e-61 205.8 22.8 1.2e-60 205.3 15.8 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family DUF370 PF04025.7 ESS61331.1 - 0.15 12.0 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF370) HemY_N PF07219.8 ESS61331.1 - 4.7 6.8 5.4 1.3 8.6 1.3 1.9 2 0 0 2 2 2 0 HemY protein N-terminus Pro_dh PF01619.13 ESS61332.1 - 9.3e-54 182.5 0.3 9.3e-54 182.5 0.2 1.6 2 0 0 2 2 2 1 Proline dehydrogenase EF-hand_8 PF13833.1 ESS61332.1 - 0.0015 18.1 0.0 0.0039 16.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 ESS61332.1 - 0.0023 18.0 0.0 0.0054 16.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Peptidase_M3 PF01432.15 ESS61334.1 - 5.2e-85 286.2 0.0 5.7e-85 286.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 ESS61334.1 - 0.031 13.6 0.1 0.052 12.9 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Peptidase_M3 PF01432.15 ESS61335.1 - 3.1e-15 56.1 1.2 3.1e-15 56.1 0.8 1.5 2 0 0 2 2 2 1 Peptidase family M3 HHH_6 PF14579.1 ESS61335.1 - 0.088 12.8 0.9 1.6 8.8 0.1 3.1 4 0 0 4 4 4 0 Helix-hairpin-helix motif DUF2508 PF10704.4 ESS61335.1 - 0.34 11.1 5.9 0.61 10.3 2.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) DGF-1_5 PF11038.3 ESS61337.1 - 1e-156 520.2 17.9 1e-156 520.2 12.4 1.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61337.1 - 9.6e-50 166.4 1.3 2.5e-49 165.0 0.9 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61337.1 - 1.7e-40 137.2 17.4 5e-40 135.7 12.0 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS61338.1 - 5e-09 35.2 0.2 1e-08 34.2 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS61339.1 - 7.7e-27 94.1 1.0 1.3e-26 93.4 0.2 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61339.1 - 1.8e-09 38.0 0.1 3.1e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61340.1 - 3.3e-11 42.8 9.6 7e-11 41.8 6.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS61340.1 - 4.5e-10 39.9 2.0 7.1e-10 39.3 1.4 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Atg14 PF10186.4 ESS61341.1 - 0.15 10.9 2.7 0.16 10.8 1.9 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3574 PF12098.3 ESS61341.1 - 0.16 11.5 0.9 0.21 11.1 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3574) Sperm_Ag_HE2 PF05324.8 ESS61342.1 - 0.034 14.0 0.1 0.056 13.3 0.1 1.3 1 0 0 1 1 1 0 Sperm antigen HE2 RHSP PF07999.6 ESS61344.1 - 1.7e-32 112.6 0.0 2.1e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF348 PF03990.9 ESS61345.1 - 0.067 12.7 0.1 0.19 11.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF348) DUF3676 PF12429.3 ESS61347.1 - 4.3e-103 343.8 42.4 6.8e-103 343.2 29.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS61347.1 - 8.4e-75 251.7 0.0 8.4e-75 251.7 0.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61347.1 - 2.8e-09 36.6 2.7 5.7e-09 35.6 1.9 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61349.1 - 1.2e-126 421.9 4.2 1.2e-126 421.9 2.9 2.2 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61349.1 - 3.3e-17 63.1 0.3 7.6e-17 61.9 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61349.1 - 5.6e-09 35.7 12.8 1.2e-08 34.6 8.9 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Neur_chan_memb PF02932.11 ESS61350.1 - 0.64 9.8 5.5 0.8 9.5 3.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Crisp PF08562.5 ESS61351.1 - 1 9.6 6.0 9 6.6 1.7 2.5 2 0 0 2 2 2 0 Crisp BNR_3 PF13859.1 ESS61352.1 - 9.4e-130 432.1 8.2 9.4e-130 432.1 5.7 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61352.1 - 5.8e-17 62.3 0.1 1.4e-16 61.1 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61352.1 - 6.3e-09 35.5 10.9 6.3e-09 35.5 7.6 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS61352.1 - 0.037 12.9 0.0 0.086 11.8 0.0 1.6 1 0 0 1 1 1 0 Sialidase, N-terminal domain Miro PF08477.8 ESS61355.1 - 6.7e-05 23.3 0.0 0.0002 21.8 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein AAA_14 PF13173.1 ESS61355.1 - 0.052 13.4 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ras PF00071.17 ESS61356.1 - 6.5e-49 165.4 2.0 8.3e-49 165.0 1.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS61356.1 - 1.1e-16 61.3 0.8 1.8e-16 60.7 0.2 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESS61356.1 - 6.6e-09 35.2 0.2 9.1e-09 34.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESS61356.1 - 5.5e-06 26.3 0.1 9.2e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ESS61356.1 - 0.0014 18.1 0.3 0.14 11.5 0.0 2.6 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 ESS61356.1 - 0.0019 17.6 2.6 0.013 14.9 0.3 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESS61356.1 - 0.0046 16.1 0.1 0.0078 15.3 0.1 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESS61356.1 - 0.02 14.0 0.0 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 ESS61356.1 - 0.03 13.6 0.3 1.4 8.1 0.1 2.4 2 1 0 2 2 2 0 Ferrous iron transport protein B MobB PF03205.9 ESS61356.1 - 0.081 12.6 0.3 0.29 10.8 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DnaJ PF00226.26 ESS61357.1 - 4.2e-27 93.6 1.2 6.6e-27 93.0 0.8 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESS61357.1 - 6.4e-22 77.2 0.5 1.2e-19 69.9 0.1 2.3 2 0 0 2 2 2 2 DnaJ C terminal domain Guanylate_cyc PF00211.15 ESS61359.1 - 2.6e-47 160.5 0.0 4.4e-47 159.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PrgI PF12666.2 ESS61359.1 - 0.0079 16.3 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 PrgI family protein MtrF PF09472.5 ESS61359.1 - 0.046 12.9 5.3 0.13 11.4 3.7 1.8 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Amidohydro_2 PF04909.9 ESS61359.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase DGF-1_5 PF11038.3 ESS61360.1 - 6.5e-162 537.2 19.3 6.5e-162 537.2 13.4 3.8 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61360.1 - 5.1e-48 160.8 1.4 1.6e-47 159.2 0.9 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61360.1 - 5.4e-33 113.1 19.0 2e-32 111.3 13.2 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_5 PF11038.3 ESS61361.1 - 3.6e-162 538.1 18.0 7e-162 537.1 12.5 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61361.1 - 2.3e-34 117.1 2.4 5.9e-34 115.8 1.7 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61361.1 - 9.6e-14 51.5 2.8 3.2e-13 49.8 1.9 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS61362.1 - 0.32 10.7 5.8 12 5.6 4.1 2.9 2 1 0 2 2 2 0 Right handed beta helix region RskA PF10099.4 ESS61362.1 - 0.36 10.5 6.5 0.86 9.3 3.8 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF3568 PF12092.3 ESS61362.1 - 2.4 7.8 5.6 4.5 6.9 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) Laminin_G_3 PF13385.1 ESS61365.1 - 5.1e-11 43.0 0.0 1.1e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61365.1 - 2e-06 27.5 7.1 4.2e-06 26.5 5.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61365.1 - 3.2e-05 23.1 0.0 6.6e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS61366.1 - 6e-50 170.0 1.4 8.2e-50 169.6 1.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS61366.1 - 4.1e-05 22.7 4.1 0.084 12.7 0.3 3.2 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.1 ESS61366.1 - 0.001 18.4 0.2 0.0027 17.0 0.1 1.8 1 1 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS61368.1 - 6.9e-36 123.7 0.1 8e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS61369.1 - 9.5e-164 543.3 16.5 9.5e-164 543.3 11.4 2.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61369.1 - 3.8e-48 161.2 1.8 1.2e-47 159.7 1.3 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61369.1 - 5.5e-34 116.3 12.7 1.5e-33 114.9 8.8 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS61371.1 - 6.7e-59 199.4 1.7 1e-58 198.8 1.2 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS61372.1 - 6.1e-63 212.7 1.5 8.5e-63 212.2 0.2 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61372.1 - 2.1e-16 60.5 2.5 4.5e-16 59.4 1.7 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61372.1 - 2.4e-09 36.8 13.2 5.8e-09 35.6 9.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS61374.1 - 6.8e-127 422.4 20.8 6.8e-127 422.4 14.4 1.7 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61374.1 - 9.5e-37 124.7 2.9 2e-36 123.7 2.0 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61375.1 - 1.1e-41 141.0 19.4 3.1e-41 139.6 13.5 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS61383.1 - 2.3e-121 405.4 0.0 3.9e-121 404.6 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3676 PF12429.3 ESS61385.1 - 1.4e-101 338.9 39.0 2.3e-101 338.2 27.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Laminin_G_3 PF13385.1 ESS61385.1 - 3.5e-11 43.5 1.1 7.9e-11 42.4 0.8 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61385.1 - 4.1e-11 42.5 7.3 7.7e-11 41.6 5.1 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4131 PF13567.1 ESS61386.1 - 1.2 8.5 10.6 1.5 8.2 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Lig_chan PF00060.21 ESS61386.1 - 3.5 7.3 5.4 4.5 6.9 3.7 1.1 1 0 0 1 1 1 0 Ligand-gated ion channel BNR_3 PF13859.1 ESS61387.1 - 2.2e-133 444.1 4.6 2.2e-133 444.1 3.2 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61387.1 - 1e-17 64.8 0.7 3.1e-17 63.2 0.5 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61387.1 - 1.7e-10 40.5 9.6 4.5e-10 39.2 6.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Med13_C PF06333.7 ESS61388.1 - 1.4 7.3 6.6 2.3 6.6 4.6 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal RVT_1 PF00078.22 ESS61393.1 - 0.0017 17.7 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.6 ESS61395.1 - 1.7e-105 353.2 0.1 2.6e-105 352.5 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61397.1 - 1.3e-24 86.6 0.7 2e-24 86.0 0.5 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF348 PF03990.9 ESS61397.1 - 0.032 13.7 0.1 0.2 11.2 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF348) Fzo_mitofusin PF04799.8 ESS61399.1 - 3.5 6.9 10.1 1.5 8.2 2.7 2.5 2 0 0 2 2 2 0 fzo-like conserved region PPR_2 PF13041.1 ESS61400.1 - 1.7e-05 24.7 0.1 0.31 11.0 0.0 4.3 3 1 1 4 4 4 2 PPR repeat family PPR PF01535.15 ESS61400.1 - 3.2e-05 23.6 3.5 0.043 13.7 0.1 4.6 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.1 ESS61400.1 - 0.00033 20.7 3.0 0.16 12.3 0.0 4.9 6 0 0 6 6 6 1 Pentatricopeptide repeat domain Pneumo_NS1 PF03438.8 ESS61400.1 - 0.17 11.7 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Pneumovirus NS1 protein Macoilin PF09726.4 ESS61402.1 - 0.63 8.2 13.3 0.74 8.0 9.2 1.0 1 0 0 1 1 1 0 Transmembrane protein Suf PF05843.9 ESS61402.1 - 3.4 7.3 6.4 4.5 6.9 4.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Otopetrin PF03189.8 ESS61402.1 - 9.7 5.0 9.9 12 4.7 6.8 1.2 1 0 0 1 1 1 0 Otopetrin Cyclin_N PF00134.18 ESS61403.1 - 0.023 14.2 0.3 0.53 9.8 0.0 2.1 2 0 0 2 2 2 0 Cyclin, N-terminal domain Vps39_2 PF10367.4 ESS61404.1 - 2.8e-24 85.3 1.1 7.4e-24 84.0 0.8 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 ESS61404.1 - 0.00032 20.2 0.1 0.019 14.5 0.0 3.0 3 0 0 3 3 3 1 Region in Clathrin and VPS BNR_3 PF13859.1 ESS61407.1 - 5.3e-62 209.6 0.8 5.3e-62 209.6 0.6 2.1 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61407.1 - 2.2e-17 63.7 0.6 4.3e-17 62.8 0.4 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61407.1 - 1.5e-11 43.9 14.7 3.6e-11 42.7 10.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal TMCO5 PF14992.1 ESS61408.1 - 0.75 8.8 8.1 0.85 8.7 5.6 1.1 1 0 0 1 1 1 0 TMCO5 family Mucin PF01456.12 ESS61411.1 - 1.9e-23 82.8 11.2 1.9e-23 82.8 7.8 3.2 3 0 0 3 3 3 1 Mucin-like glycoprotein Synaphin PF05835.7 ESS61413.1 - 0.17 12.0 3.1 0.24 11.5 2.1 1.1 1 0 0 1 1 1 0 Synaphin protein BNR_3 PF13859.1 ESS61415.1 - 2.5e-107 358.5 8.1 5.7e-107 357.3 5.6 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61415.1 - 1.5e-17 64.2 0.5 5.2e-17 62.5 0.4 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61415.1 - 3.3e-08 33.2 10.7 6.7e-08 32.2 7.4 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Suppressor_P21 PF11479.3 ESS61416.1 - 0.094 12.4 0.0 0.096 12.4 0.0 1.1 1 0 0 1 1 1 0 RNA silencing suppressor P21 RHSP PF07999.6 ESS61421.1 - 3.5e-45 154.4 0.7 3.5e-45 154.4 0.5 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein Beta_helix PF13229.1 ESS61426.1 - 0.02 14.6 0.1 0.31 10.7 0.0 2.1 2 0 0 2 2 2 0 Right handed beta helix region Galactosyl_T PF01762.16 ESS61429.1 - 2.7e-10 40.1 0.0 0.0002 20.9 0.0 3.7 3 1 1 4 4 4 2 Galactosyltransferase RVT_1 PF00078.22 ESS61431.1 - 6.3e-09 35.5 0.0 8.3e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DGF-1_C PF11040.3 ESS61432.1 - 2.7e-48 161.7 1.7 5e-48 160.8 1.2 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS61432.1 - 2.8e-22 79.2 3.5 2.8e-22 79.2 2.4 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_5 PF11038.3 ESS61433.1 - 4.2e-49 167.2 0.0 4.2e-49 167.2 0.0 3.3 4 0 0 4 4 4 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS61433.1 - 5.6e-39 132.3 16.2 5.6e-39 132.3 11.2 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS61437.1 - 8.2e-28 97.3 2.6 7.2e-27 94.2 0.1 2.2 2 0 0 2 2 2 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61437.1 - 1.5e-16 60.9 0.7 2.2e-16 60.4 0.5 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS61438.1 - 7.1e-54 182.9 0.8 8.7e-54 182.6 0.5 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61438.1 - 0.06 12.6 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 BNR repeat-like domain RHSP PF07999.6 ESS61439.1 - 1.1e-110 370.2 0.0 1.5e-110 369.8 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein FtsL PF04999.8 ESS61439.1 - 0.4 10.4 4.6 29 4.4 0.1 3.2 3 0 0 3 3 3 0 Cell division protein FtsL PH PF00169.24 ESS61441.1 - 0.01 16.0 0.2 0.19 11.9 0.0 2.5 2 1 0 2 2 2 0 PH domain Kinetochor_Ybp2 PF08568.5 ESS61442.1 - 0.063 11.5 0.2 0.28 9.4 0.1 1.8 2 0 0 2 2 2 0 Uncharacterised protein family, YAP/Alf4/glomulin RHSP PF07999.6 ESS61443.1 - 2.2e-79 267.1 2.1 3.1e-79 266.6 1.5 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein HK97-gp10_like PF04883.7 ESS61443.1 - 0.035 15.0 0.1 1.9 9.4 0.0 2.7 2 1 0 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component AAA_10 PF12846.2 ESS61443.1 - 0.048 13.0 0.1 0.091 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 ESS61443.1 - 0.084 13.0 0.2 0.9 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Herpes_LAMP2 PF06126.6 ESS61445.1 - 0.44 8.8 5.6 0.49 8.7 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 RHSP PF07999.6 ESS61446.1 - 3.7e-126 421.2 4.3 7.8e-126 420.1 0.0 2.1 2 0 0 2 2 2 1 Retrotransposon hot spot protein Squash PF00299.13 ESS61446.1 - 3.7 7.4 5.4 1 9.2 0.5 2.1 2 0 0 2 2 2 0 Squash family serine protease inhibitor rpo132 PF12415.3 ESS61447.1 - 0.035 13.0 0.1 0.14 11.1 0.0 2.0 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase RHSP PF07999.6 ESS61448.1 - 2.1e-85 286.9 0.3 3.7e-85 286.1 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein Cauli_AT PF03233.8 ESS61448.1 - 0.018 14.7 0.2 0.033 13.9 0.1 1.4 1 0 0 1 1 1 0 Aphid transmission protein AAA_22 PF13401.1 ESS61448.1 - 0.071 13.2 0.1 14 5.8 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_10 PF12846.2 ESS61448.1 - 0.086 12.2 1.3 12 5.1 0.3 2.8 2 1 0 2 2 2 0 AAA-like domain RHSP PF07999.6 ESS61450.1 - 6e-56 189.8 0.7 7.9e-56 189.4 0.5 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein PDE8 PF08629.5 ESS61450.1 - 0.09 12.5 0.1 0.23 11.2 0.1 1.7 1 0 0 1 1 1 0 PDE8 phosphodiesterase POTRA_1 PF08478.5 ESS61454.1 - 0.11 12.4 1.1 0.66 10.0 0.0 2.9 4 0 0 4 4 4 0 POTRA domain, FtsQ-type DGF-1_C PF11040.3 ESS61456.1 - 1.6e-34 117.6 2.6 3.1e-34 116.6 1.8 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_5 PF11038.3 ESS61456.1 - 2.3e-12 46.7 0.9 2.3e-12 46.7 0.6 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 SCFA_trans PF02667.9 ESS61456.1 - 0.0048 15.7 0.3 0.008 15.0 0.2 1.3 1 0 0 1 1 1 1 Short chain fatty acid transporter Telomere_reg-2 PF10193.4 ESS61458.1 - 0.00049 20.3 0.4 0.0025 18.0 0.0 2.5 3 0 0 3 3 3 1 Telomere length regulation protein RHH_2 PF03693.9 ESS61459.1 - 0.083 13.0 0.1 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0156) Pex26 PF07163.7 ESS61459.1 - 0.11 11.3 0.1 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Pex26 protein MerR-DNA-bind PF09278.6 ESS61460.1 - 0.0041 17.4 11.2 0.0041 17.4 7.8 3.8 4 2 0 4 4 4 1 MerR, DNA binding TFIIE_alpha PF02002.12 ESS61460.1 - 4.2 6.9 10.8 0.13 11.7 0.7 2.7 2 2 1 4 4 4 0 TFIIE alpha subunit D123 PF07065.9 ESS61460.1 - 7.9 5.4 10.7 0.12 11.3 0.7 2.1 2 1 0 2 2 2 0 D123 DUF912 PF06024.7 ESS61461.1 - 0.02 14.9 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4448 PF14610.1 ESS61461.1 - 0.027 13.9 0.0 0.028 13.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Anoctamin PF04547.7 ESS61461.1 - 0.068 11.8 0.2 0.075 11.6 0.2 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel AAA_11 PF13086.1 ESS61461.1 - 0.2 11.1 1.9 0.23 11.0 1.3 1.0 1 0 0 1 1 1 0 AAA domain F-box-like PF12937.2 ESS61462.1 - 0.00015 21.4 0.2 0.00075 19.1 0.0 2.3 2 0 0 2 2 2 1 F-box-like IncA PF04156.9 ESS61464.1 - 0.033 13.7 0.0 0.063 12.8 0.0 1.4 1 0 0 1 1 1 0 IncA protein Galactosyl_T PF01762.16 ESS61468.1 - 1.2e-05 24.9 0.2 0.00056 19.5 0.0 2.6 1 1 1 2 2 2 2 Galactosyltransferase MORN PF02493.15 ESS61469.1 - 2.3e-29 99.3 55.1 3.3e-07 29.6 3.0 7.6 7 0 0 7 7 7 7 MORN repeat Kinesin PF00225.18 ESS61470.1 - 2e-14 53.0 0.3 4.4e-10 38.7 0.0 2.3 2 1 0 2 2 2 2 Kinesin motor domain Lebercilin PF15619.1 ESS61470.1 - 0.00026 20.4 8.8 0.00043 19.7 6.1 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease CCDC144C PF14915.1 ESS61470.1 - 0.01 14.8 7.2 0.035 13.0 4.4 1.9 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region DUF4391 PF14335.1 ESS61470.1 - 0.21 10.9 2.6 1.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4391) APG6 PF04111.7 ESS61470.1 - 0.54 9.2 5.8 0.92 8.4 4.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 ESS61470.1 - 2.8 7.4 9.1 6.1 6.3 6.3 1.5 1 0 0 1 1 1 0 IncA protein DNA_pol_A_exo1 PF01612.15 ESS61471.1 - 1.3e-11 44.2 0.0 2.1e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 3'-5' exonuclease Nodulin-like PF06813.8 ESS61472.1 - 7.4e-07 28.6 13.5 7.4e-07 28.6 9.4 2.9 2 1 0 2 2 2 1 Nodulin-like PPR PF01535.15 ESS61473.1 - 0.023 14.6 0.0 4 7.6 0.0 3.9 3 0 0 3 3 3 0 PPR repeat BNR_3 PF13859.1 ESS61477.1 - 5.6e-132 439.5 6.3 5.6e-132 439.5 4.4 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61477.1 - 4.4e-17 62.7 0.0 1.3e-16 61.2 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61477.1 - 4.3e-10 39.2 9.5 1.3e-09 37.7 6.6 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Myb_DNA-bind_4 PF13837.1 ESS61481.1 - 0.43 10.7 3.6 0.72 10.0 0.6 2.3 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Acyltransferase PF01553.16 ESS61485.1 - 8.4e-17 60.8 0.0 2e-16 59.6 0.0 1.6 2 0 0 2 2 2 1 Acyltransferase SapB_1 PF05184.10 ESS61486.1 - 0.037 13.8 0.5 0.072 12.9 0.3 1.5 1 0 0 1 1 1 0 Saposin-like type B, region 1 CTDII PF01556.13 ESS61487.1 - 2.7e-22 78.4 0.0 4.7e-17 61.6 0.0 2.4 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 ESS61487.1 - 1.2e-15 57.0 0.2 2e-15 56.2 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.1 ESS61487.1 - 0.17 11.3 0.0 0.53 9.7 0.0 1.8 2 0 0 2 2 2 0 A repeated domain in UCH-protein DSBA PF01323.15 ESS61488.1 - 0.19 11.2 1.9 0.51 9.8 1.3 1.7 1 0 0 1 1 1 0 DSBA-like thioredoxin domain WD40_alt PF14077.1 ESS61489.1 - 0.03 13.9 0.3 0.063 12.9 0.2 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif DUF647 PF04884.9 ESS61490.1 - 3.8e-24 85.2 3.9 5.8e-24 84.6 2.7 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis ParBc_2 PF08857.6 ESS61491.1 - 0.034 13.9 8.5 0.041 13.7 5.9 1.1 1 0 0 1 1 1 0 Putative ParB-like nuclease DUF2244 PF10003.4 ESS61491.1 - 0.57 9.5 5.5 0.63 9.4 3.8 1.1 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) SelP_N PF04592.9 ESS61491.1 - 1.4 8.2 17.5 1.7 7.9 12.1 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region BNR_3 PF13859.1 ESS61496.1 - 5.4e-65 219.4 0.3 1.1e-64 218.4 0.2 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61496.1 - 1.9e-18 67.1 0.8 5.2e-18 65.7 0.5 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61496.1 - 9.8e-11 41.3 14.5 2.3e-10 40.1 10.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Treacle PF03546.9 ESS61498.1 - 0.046 12.5 6.1 0.056 12.2 4.2 1.0 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle CENP-B_dimeris PF09026.5 ESS61498.1 - 9.5 6.5 7.7 5 7.4 1.2 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4106 PF13388.1 ESS61499.1 - 1.3 7.8 8.6 2.1 7.2 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) RHSP PF07999.6 ESS61507.1 - 1.6e-172 574.0 0.0 2.3e-172 573.5 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61507.1 - 0.16 12.1 0.2 0.85 9.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain Laminin_G_3 PF13385.1 ESS61509.1 - 3.2e-16 59.9 0.4 3.2e-16 59.9 0.3 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61509.1 - 1.7e-09 37.3 9.6 4e-09 36.1 6.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Na_trans_assoc PF06512.8 ESS61509.1 - 1.3 8.9 3.8 0.88 9.4 1.4 1.7 2 0 0 2 2 2 0 Sodium ion transport-associated IgG_binding_B PF01378.12 ESS61510.1 - 0.31 10.8 1.7 0.72 9.7 1.2 1.5 1 0 0 1 1 1 0 B domain BNR_3 PF13859.1 ESS61511.1 - 4.9e-18 65.2 0.0 1.9e-17 63.3 0.0 1.8 1 1 0 1 1 1 1 BNR repeat-like domain LAT PF15234.1 ESS61513.1 - 4.9e-05 22.9 8.6 4.9e-05 22.9 6.0 2.4 1 1 0 2 2 2 1 Linker for activation of T-cells Utp14 PF04615.8 ESS61513.1 - 0.97 7.5 33.5 1.5 6.9 23.2 1.3 1 0 0 1 1 1 0 Utp14 protein BNR_3 PF13859.1 ESS61514.1 - 3.7e-134 446.6 3.6 6.7e-134 445.8 2.5 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61514.1 - 4e-09 36.1 10.8 9.2e-09 35.0 7.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61518.1 - 1.8e-127 424.7 6.4 3.7e-127 423.6 4.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61518.1 - 1.3e-17 64.4 0.8 1.3e-17 64.4 0.6 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61518.1 - 6e-10 38.8 14.8 1.7e-09 37.3 10.3 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS61518.1 - 0.081 12.7 0.5 1.1e+02 3.2 0.0 4.2 3 0 0 3 3 3 0 BNR/Asp-box repeat Ctr PF04145.10 ESS61519.1 - 0.092 12.7 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family BNR_3 PF13859.1 ESS61520.1 - 3.6e-130 433.5 6.0 3.6e-130 433.5 4.1 2.1 3 0 0 3 3 3 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61520.1 - 2.8e-09 36.6 13.9 7.6e-09 35.2 9.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal TFIIA PF03153.8 ESS61522.1 - 1.1 9.1 22.6 1.1 9.0 15.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Asp-B-Hydro_N PF05279.6 ESS61522.1 - 2.2 8.0 24.0 2.7 7.7 16.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Sec1 PF00995.18 ESS61523.1 - 9.9e-11 40.9 0.0 1.3e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Sec1 family BNR_3 PF13859.1 ESS61524.1 - 1.2e-128 428.5 3.3 1.2e-128 428.5 2.3 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61524.1 - 5.3e-20 72.2 0.6 1.3e-19 70.9 0.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61524.1 - 9.4e-07 28.5 14.3 9.4e-07 28.5 9.9 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal TFIIA PF03153.8 ESS61526.1 - 9.5 5.9 9.5 12 5.6 6.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DGF-1_5 PF11038.3 ESS61529.1 - 8.4e-164 543.4 18.4 8.4e-164 543.4 12.8 3.1 4 0 0 4 4 4 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61529.1 - 5e-49 164.1 1.4 5e-49 164.1 1.0 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61529.1 - 6.2e-38 129.0 15.8 1.8e-37 127.5 11.0 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS61530.1 - 9.6e-29 100.4 0.1 9.6e-29 100.4 0.1 2.2 3 1 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61530.1 - 2.8e-17 63.4 2.8 3.5e-17 63.0 1.5 1.4 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61530.1 - 1.1e-10 41.1 13.3 2.3e-10 40.1 9.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Pox_P21 PF05313.7 ESS61531.1 - 0.061 12.5 0.0 0.064 12.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P21 membrane protein Phage_Gp23 PF10669.4 ESS61532.1 - 0.052 13.6 0.1 0.062 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) CWC25 PF12542.3 ESS61532.1 - 0.11 12.9 1.9 0.18 12.2 1.3 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor DUF3720 PF12517.3 ESS61533.1 - 5.5e-18 65.4 17.0 5.5e-18 65.4 11.8 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF3720) Zip PF02535.17 ESS61533.1 - 4.1 6.3 11.1 5.3 5.9 7.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter zf-C2H2_4 PF13894.1 ESS61534.1 - 0.00087 19.4 4.7 0.11 12.9 0.3 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESS61534.1 - 0.042 13.7 1.2 1.3 9.0 0.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS61534.1 - 0.069 13.5 5.5 0.56 10.6 0.4 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Mucin PF01456.12 ESS61537.1 - 2.3e-33 115.0 45.1 9.2e-32 109.7 31.2 2.2 1 1 0 1 1 1 1 Mucin-like glycoprotein SOG2 PF10428.4 ESS61537.1 - 0.26 9.8 14.0 0.33 9.5 9.7 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3484 PF11983.3 ESS61537.1 - 2.3 9.0 11.8 10 7.0 2.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3484) FA PF08736.6 ESS61538.1 - 0.12 12.1 2.5 0.31 10.8 1.7 1.7 1 0 0 1 1 1 0 FERM adjacent (FA) Laminin_G_3 PF13385.1 ESS61539.1 - 2.3e-14 53.9 0.1 4.8e-14 52.8 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61539.1 - 4.3e-10 39.2 11.9 1.1e-09 37.9 8.2 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS61539.1 - 0.071 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Sialidase, N-terminal domain BNR_3 PF13859.1 ESS61540.1 - 3e-102 341.8 3.3 3.9e-102 341.4 2.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61540.1 - 0.00061 19.1 0.1 0.00085 18.6 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS61541.1 - 1.9e-10 40.6 65.1 2.1e-08 34.0 25.1 3.3 1 1 1 2 2 2 2 Mucin-like glycoprotein Neur_chan_memb PF02932.11 ESS61541.1 - 10 5.9 8.5 1.3 8.8 3.1 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BNR_3 PF13859.1 ESS61543.1 - 1e-130 435.3 2.8 1.8e-130 434.5 1.9 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61544.1 - 2.6e-10 39.9 11.9 4.3e-10 39.2 8.2 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61546.1 - 4.1e-130 433.3 4.3 4.1e-130 433.3 3.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61546.1 - 2.3e-17 63.6 0.5 9.8e-17 61.6 0.4 2.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61546.1 - 1.1e-10 41.1 11.1 2.7e-10 39.9 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal KASH PF10541.4 ESS61547.1 - 0.24 11.2 2.6 0.69 9.8 1.8 1.8 1 1 0 1 1 1 0 Nuclear envelope localisation domain Corona_S2 PF01601.11 ESS61554.1 - 0.32 9.0 3.0 0.38 8.7 2.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Zip PF02535.17 ESS61555.1 - 1.8 7.4 7.6 2.5 7.0 5.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BNR_3 PF13859.1 ESS61556.1 - 1.1e-132 441.8 7.5 1.7e-132 441.2 5.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61556.1 - 3.2e-18 66.4 0.9 6.8e-18 65.3 0.6 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Exo_endo_phos_2 PF14529.1 ESS61559.1 - 0.0072 15.9 0.1 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ASRT PF07100.6 ESS61561.1 - 0.049 13.3 0.0 0.091 12.5 0.0 1.4 1 1 0 1 1 1 0 Anabaena sensory rhodopsin transducer NAD_binding_11 PF14833.1 ESS61562.1 - 0.0052 16.8 0.5 0.25 11.4 0.0 2.5 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase GAS PF13851.1 ESS61563.1 - 8.4e-05 21.8 2.9 8.4e-05 21.8 2.0 7.8 3 2 5 8 8 8 3 Growth-arrest specific micro-tubule binding Vac_Fusion PF02346.11 ESS61563.1 - 2 7.9 19.6 0.47 9.9 0.3 5.3 5 0 0 5 5 5 0 Chordopoxvirus fusion protein ADH_zinc_N PF00107.21 ESS61565.1 - 1.5e-14 53.6 1.1 3e-14 52.6 0.6 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESS61565.1 - 4.5e-11 43.7 0.0 9.2e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESS61565.1 - 1.4e-06 28.0 0.0 2.1e-05 24.2 0.0 2.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain CAF1A PF12253.3 ESS61566.1 - 0.0023 18.0 21.6 0.0023 18.0 15.0 4.3 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A SDA1 PF05285.7 ESS61566.1 - 0.063 12.5 32.0 0.14 11.3 8.1 3.4 3 0 0 3 3 3 0 SDA1 Podoplanin PF05808.6 ESS61566.1 - 0.51 9.8 5.4 3.1 7.3 0.0 2.7 1 1 1 2 2 2 0 Podoplanin ABC1 PF03109.11 ESS61568.1 - 1.9e-22 79.4 0.0 3.7e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 ABC1 family DGF-1_5 PF11038.3 ESS61570.1 - 3.2e-79 266.0 1.9 3.2e-79 266.0 1.3 3.3 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS61570.1 - 5.9e-35 119.4 17.7 1.6e-34 118.0 12.3 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS61573.1 - 2.7e-16 59.2 0.1 4.7e-16 58.4 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61574.1 - 2.8e-50 171.1 0.0 3.2e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS61575.1 - 1.3e-160 533.0 17.9 1.3e-160 533.0 12.4 2.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61575.1 - 1e-42 143.9 2.0 3.4e-42 142.2 1.4 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61575.1 - 1.4e-36 124.6 17.8 5e-36 122.9 12.3 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Arb1 PF09692.5 ESS61575.1 - 5.9 5.6 0.0 9.2 4.9 0.0 1.1 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 CorA PF01544.13 ESS61576.1 - 3.3e-14 52.6 4.7 3.3e-09 36.2 1.1 2.3 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Peptidase_M20 PF01546.23 ESS61577.1 - 8.8e-25 87.3 0.0 1.9e-24 86.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESS61577.1 - 4.2e-22 78.0 0.0 6.7e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain MLANA PF14991.1 ESS61578.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A Vpu PF00558.14 ESS61578.1 - 4 7.0 4.9 7.6 6.1 3.4 1.4 1 0 0 1 1 1 0 Vpu protein DUF4605 PF15378.1 ESS61580.1 - 0.56 9.9 2.1 0.89 9.2 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) UPF0197 PF05251.7 ESS61580.1 - 0.57 10.5 3.5 0.88 9.9 2.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0197) Dus PF01207.12 ESS61581.1 - 1.6e-60 204.6 0.0 3.5e-60 203.4 0.0 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 ESS61581.1 - 0.039 12.9 0.0 0.5 9.2 0.0 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Glyco_trans_4_4 PF13579.1 ESS61582.1 - 0.0052 16.9 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain PgaD PF13994.1 ESS61582.1 - 0.24 10.9 1.4 0.26 10.7 0.1 1.7 2 0 0 2 2 2 0 PgaD-like protein zf-P11 PF03854.9 ESS61583.1 - 0.036 13.5 0.2 0.08 12.4 0.1 1.5 1 0 0 1 1 1 0 P-11 zinc finger FYVE PF01363.16 ESS61583.1 - 0.11 12.3 0.5 0.27 11.1 0.4 1.5 1 0 0 1 1 1 0 FYVE zinc finger DUF389 PF04087.9 ESS61583.1 - 0.39 10.6 5.2 0.77 9.7 0.4 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF389) FeoB_C PF07664.7 ESS61583.1 - 0.69 9.3 10.5 0.97 8.9 0.3 3.3 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus Stm1_N PF09598.5 ESS61584.1 - 2.1 9.1 10.2 0.11 13.1 3.2 1.7 2 0 0 2 2 2 0 Stm1 Band_7 PF01145.20 ESS61586.1 - 1e-20 74.4 0.0 1.3e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family CpeT PF06206.6 ESS61586.1 - 0.1 12.2 0.1 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 CpeT/CpcT family (DUF1001) Aa_trans PF01490.13 ESS61587.1 - 6.8e-14 51.1 5.8 8.4e-14 50.8 4.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS61587.1 - 1.3e-09 37.3 8.6 1.8e-09 36.9 5.9 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.13 ESS61588.1 - 6.1e-22 77.6 8.7 7e-22 77.4 6.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS61588.1 - 5.5e-06 25.4 8.6 6.7e-06 25.1 6.0 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family BNR_3 PF13859.1 ESS61589.1 - 1.8e-75 253.9 0.6 3.8e-75 252.8 0.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61589.1 - 1.1e-16 61.4 3.2 2.1e-16 60.5 2.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61589.1 - 1.4e-09 37.6 11.7 3.7e-09 36.2 8.1 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61590.1 - 2.5e-23 82.6 0.1 4.4e-23 81.8 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS61592.1 - 6.3e-132 439.3 2.8 6.3e-132 439.3 2.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61592.1 - 1.8e-17 64.0 2.8 7.4e-17 62.0 0.7 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61592.1 - 1.5e-10 40.6 13.4 1.5e-10 40.6 9.3 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_C PF11040.3 ESS61594.1 - 1.1e-45 153.4 0.5 1.1e-45 153.4 0.4 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61594.1 - 9.1e-21 74.0 3.0 2.6e-20 72.5 2.1 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS61594.1 - 5.9e-08 32.6 13.0 0.0011 18.7 0.0 6.0 5 2 1 6 6 6 3 Right handed beta helix region DUF2575 PF10837.3 ESS61597.1 - 0.11 12.6 0.5 0.48 10.5 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2575) Glycos_transf_2 PF00535.21 ESS61598.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS61598.1 - 0.0027 16.8 0.0 0.16 10.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Lenti_VIF_2 PF07401.7 ESS61599.1 - 0.05 12.7 0.9 0.6 9.2 0.1 2.1 1 1 0 2 2 2 0 Bovine Lentivirus VIF protein DGF-1_5 PF11038.3 ESS61601.1 - 4e-160 531.4 17.4 4e-160 531.4 12.1 1.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61601.1 - 5.4e-49 164.0 1.4 1.2e-48 162.9 1.0 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61601.1 - 4.7e-42 142.2 15.3 1.4e-41 140.7 10.6 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Laminin_G_3 PF13385.1 ESS61606.1 - 8.2e-13 48.8 0.5 1.4e-12 48.1 0.0 1.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61606.1 - 5.7e-12 45.2 10.6 5.7e-12 45.2 7.4 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal UL73_N PF12522.3 ESS61606.1 - 0.48 9.9 10.9 0.039 13.4 3.6 2.1 2 0 0 2 2 2 0 Cytomegalovirus glycoprotein N terminal BNR_3 PF13859.1 ESS61607.1 - 1e-12 47.8 0.6 2e-12 46.8 0.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain DUF3676 PF12429.3 ESS61608.1 - 3.4e-104 347.4 45.5 5.5e-104 346.7 31.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS61608.1 - 1.2e-80 270.9 0.0 1.2e-80 270.9 0.0 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61608.1 - 2.6e-12 47.2 0.2 7e-12 45.8 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61608.1 - 7.6e-11 41.6 6.9 2e-10 40.3 4.8 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Glyco_trans_2_3 PF13632.1 ESS61609.1 - 0.0076 15.9 0.1 0.0093 15.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_2 PF10111.4 ESS61609.1 - 0.038 13.0 0.1 0.046 12.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF2575 PF10837.3 ESS61610.1 - 0.058 13.4 0.2 0.59 10.2 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2575) RNase_H PF00075.19 ESS61610.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 RNase H IFT57 PF10498.4 ESS61612.1 - 0.0079 14.9 2.2 0.011 14.4 1.5 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Myosin_tail_1 PF01576.14 ESS61612.1 - 0.026 12.2 3.6 0.036 11.8 2.5 1.1 1 0 0 1 1 1 0 Myosin tail Spc7 PF08317.6 ESS61612.1 - 0.095 11.3 0.5 0.13 10.9 0.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESS61612.1 - 0.13 11.2 7.4 0.2 10.5 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.14 ESS61612.1 - 0.22 9.3 0.2 0.27 9.0 0.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc24 PF08286.6 ESS61612.1 - 1.6 8.4 4.0 20 4.9 0.1 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 BNR_3 PF13859.1 ESS61613.1 - 1.2e-130 435.1 7.4 1.2e-130 435.1 5.1 2.0 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61613.1 - 2.4e-18 66.8 0.2 6e-18 65.5 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61613.1 - 1.4e-08 34.3 10.5 1.4e-08 34.3 7.2 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2909 PF11137.3 ESS61613.1 - 0.11 12.2 0.1 0.23 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Peptidase_M8 PF01457.11 ESS61615.1 - 1.4e-47 162.2 0.3 1.7e-47 161.9 0.2 1.1 1 0 0 1 1 1 1 Leishmanolysin TniQ PF06527.6 ESS61615.1 - 0.035 14.3 0.6 0.13 12.5 0.1 2.1 2 0 0 2 2 2 0 TniQ Peptidase_M10 PF00413.19 ESS61615.1 - 0.042 13.5 0.0 0.062 13.0 0.0 1.2 1 0 0 1 1 1 0 Matrixin Astacin PF01400.19 ESS61615.1 - 0.043 13.2 0.1 0.069 12.5 0.1 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) DUF3810 PF12725.2 ESS61615.1 - 0.09 11.6 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DUF1025 PF06262.6 ESS61615.1 - 0.098 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Possibl zinc metallo-peptidase Reprolysin_5 PF13688.1 ESS61615.1 - 0.12 12.3 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Sperm_Ag_HE2 PF05324.8 ESS61617.1 - 0.17 11.8 0.4 0.25 11.2 0.2 1.3 1 0 0 1 1 1 0 Sperm antigen HE2 PGC7_Stella PF15549.1 ESS61619.1 - 2 8.3 7.3 0.45 10.4 0.2 2.3 2 1 0 2 2 2 0 PGC7/Stella/Dppa3 domain DUF457 PF04307.9 ESS61622.1 - 0.0067 15.7 1.6 0.0067 15.7 1.1 1.8 2 0 0 2 2 2 1 Predicted membrane-bound metal-dependent hydrolase (DUF457) DUF3429 PF11911.3 ESS61622.1 - 0.12 12.3 3.6 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3429) DUF4658 PF15555.1 ESS61622.1 - 0.16 11.8 3.9 0.74 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) BNR_3 PF13859.1 ESS61624.1 - 2.1e-129 431.0 10.4 2.9e-129 430.6 7.2 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61624.1 - 2.8e-06 26.8 0.5 5.2e-06 25.9 0.1 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Glyco_hydro_32N PF00251.15 ESS61624.1 - 0.12 11.7 0.5 22 4.2 0.0 3.0 2 1 1 3 3 3 0 Glycosyl hydrolases family 32 N-terminal domain Phage_integrase PF00589.17 ESS61628.1 - 0.0018 17.9 0.1 0.0026 17.4 0.1 1.5 1 1 0 1 1 1 1 Phage integrase family RHSP PF07999.6 ESS61631.1 - 2.2e-99 333.0 1.0 3.4e-99 332.4 0.7 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF229 PF02995.12 ESS61632.1 - 1.8e-11 43.1 0.0 2.8e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF229 PF02995.12 ESS61633.1 - 1e-06 27.4 0.0 1.4e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Ammonium_transp PF00909.16 ESS61634.1 - 4.4e-100 334.9 31.6 5e-100 334.7 21.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3953 PF13129.1 ESS61636.1 - 0.054 13.1 0.1 0.58 9.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3953) Cas_Cas4 PF01930.12 ESS61637.1 - 0.013 15.4 3.1 0.013 15.4 2.2 3.4 4 0 0 4 4 4 0 Domain of unknown function DUF83 Reo_sigmaC PF04582.7 ESS61637.1 - 1.3 8.1 14.1 0.095 11.8 2.7 2.7 2 1 2 4 4 4 0 Reovirus sigma C capsid protein Peptidase_C1 PF00112.18 ESS61639.1 - 4.6e-57 193.4 3.5 6.3e-57 192.9 2.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 ESS61639.1 - 4.8e-13 49.1 0.0 7.9e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) RHSP PF07999.6 ESS61640.1 - 2.5e-64 217.4 1.5 4.9e-64 216.5 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61641.1 - 2.7e-26 92.1 1.4 2.7e-26 92.1 0.9 2.0 2 0 0 2 2 2 1 Retrotransposon hot spot protein OKR_DC_1_N PF03709.10 ESS61643.1 - 0.2 11.7 0.2 0.2 11.7 0.2 2.4 3 1 0 3 3 3 0 Orn/Lys/Arg decarboxylase, N-terminal domain Sp38 PF07354.7 ESS61643.1 - 0.34 9.5 2.0 0.2 10.3 0.1 1.7 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) ECH PF00378.15 ESS61643.1 - 5.4 6.0 6.4 1.3 8.0 1.3 2.0 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase family RHSP PF07999.6 ESS61644.1 - 1.4e-23 83.1 0.0 2.1e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61645.1 - 3.6e-37 127.9 0.0 5.8e-37 127.3 0.0 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF2788 PF10981.3 ESS61645.1 - 0.011 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2788) zf-C2HC PF01530.13 ESS61647.1 - 0.45 10.2 7.8 0.085 12.6 2.8 1.8 2 0 0 2 2 2 0 Zinc finger, C2HC type DUF3676 PF12429.3 ESS61649.1 - 3e-116 386.9 37.3 4.6e-116 386.3 25.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS61649.1 - 2.7e-11 43.1 7.2 4.3e-11 42.4 5.0 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Metallophos PF00149.23 ESS61651.1 - 4e-42 143.8 0.1 4.9e-42 143.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pyr_redox_2 PF07992.9 ESS61652.1 - 5.8e-24 85.0 0.2 9e-24 84.4 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS61652.1 - 5.9e-22 77.8 0.5 2.1e-17 63.2 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESS61652.1 - 1e-12 48.0 0.0 2.1e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.1 ESS61652.1 - 3.2e-11 43.6 0.9 7.3e-09 35.9 0.3 3.0 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESS61652.1 - 7.6e-08 31.6 8.0 0.00044 19.2 2.2 3.8 2 2 2 4 4 4 2 FAD dependent oxidoreductase FAD_oxidored PF12831.2 ESS61652.1 - 1.1e-07 31.3 1.1 1.1e-07 31.3 0.8 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESS61652.1 - 2.7e-07 30.4 0.2 0.0017 18.3 0.1 3.0 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 ESS61652.1 - 4.2e-07 29.1 0.1 0.00018 20.5 0.1 2.5 2 1 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.9 ESS61652.1 - 4.6e-07 28.6 2.7 0.00019 20.0 0.3 2.9 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.7 ESS61652.1 - 0.00014 20.9 1.5 0.016 14.1 0.3 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_2 PF00890.19 ESS61652.1 - 0.00026 19.9 5.9 0.00073 18.4 1.5 2.6 2 1 1 3 3 3 1 FAD binding domain 3HCDH_N PF02737.13 ESS61652.1 - 0.00083 19.0 0.2 0.012 15.2 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 ESS61652.1 - 0.0029 17.0 0.0 0.055 12.9 0.0 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Thi4 PF01946.12 ESS61652.1 - 0.0058 15.7 0.1 0.042 12.9 0.0 2.2 2 0 0 2 2 2 1 Thi4 family 2-Hacid_dh_C PF02826.14 ESS61652.1 - 0.0079 15.3 0.1 0.078 12.1 0.0 2.5 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 ESS61652.1 - 0.0084 15.9 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.14 ESS61652.1 - 0.047 12.7 2.3 0.091 11.7 0.4 2.3 2 1 0 2 2 2 0 FAD binding domain Shikimate_DH PF01488.15 ESS61652.1 - 0.062 13.3 0.0 2.7 8.1 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 ESS61652.1 - 0.073 13.0 2.4 2.1 8.3 0.0 3.6 5 0 0 5 5 3 0 TrkA-N domain Trp_halogenase PF04820.9 ESS61652.1 - 0.09 11.3 0.2 0.21 10.1 0.0 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Glyco_trans_1_3 PF13528.1 ESS61652.1 - 0.19 10.9 0.0 0.42 9.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 1 Pyr_redox_2 PF07992.9 ESS61653.1 - 1.8e-28 99.8 0.1 2.5e-27 96.0 0.0 3.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESS61653.1 - 2.7e-16 59.5 0.0 5.7e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ESS61653.1 - 1.3e-15 57.5 1.2 1.6e-12 47.6 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESS61653.1 - 5.3e-11 42.2 0.6 5.1e-10 39.0 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESS61653.1 - 4.9e-09 36.5 0.5 1.9e-08 34.6 0.1 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESS61653.1 - 2e-08 33.5 0.3 0.00036 19.5 0.5 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.17 ESS61653.1 - 6.9e-07 28.4 0.7 0.0016 17.4 0.8 3.0 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESS61653.1 - 3e-06 27.1 2.6 0.001 19.0 0.2 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 ESS61653.1 - 5.4e-06 25.1 4.2 6.5e-05 21.5 0.2 3.3 3 1 1 4 4 4 1 HI0933-like protein FAD_binding_2 PF00890.19 ESS61653.1 - 3.1e-05 22.9 5.4 0.00014 20.8 0.9 2.8 2 1 1 3 3 3 1 FAD binding domain K_oxygenase PF13434.1 ESS61653.1 - 0.00011 21.2 0.1 0.0046 15.9 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 ESS61653.1 - 0.00021 20.4 0.2 0.0018 17.3 0.0 2.3 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.7 ESS61653.1 - 0.00034 19.6 0.8 0.012 14.5 0.3 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 ESS61653.1 - 0.00098 18.2 0.4 0.11 11.5 0.0 2.9 3 0 0 3 3 3 1 FAD binding domain 3HCDH_N PF02737.13 ESS61653.1 - 0.002 17.8 0.3 0.067 12.8 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 ESS61653.1 - 0.0047 17.1 0.0 1.1 9.5 0.0 2.8 2 1 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 ESS61653.1 - 0.0072 15.9 1.1 0.31 10.6 0.0 2.9 2 1 1 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.9 ESS61653.1 - 0.012 14.2 0.1 3.8 6.0 0.0 2.5 2 0 0 2 2 2 0 Tryptophan halogenase ThiF PF00899.16 ESS61653.1 - 0.024 14.4 0.5 0.14 11.9 0.0 2.3 2 0 0 2 2 2 0 ThiF family NAD_Gly3P_dh_N PF01210.18 ESS61653.1 - 0.1 12.3 0.0 4.9 6.8 0.0 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus CRAL_TRIO PF00650.15 ESS61657.1 - 4.6e-16 58.7 0.0 8.9e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain BNR_3 PF13859.1 ESS61660.1 - 2.1e-129 431.0 4.0 2.1e-129 431.0 2.8 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61660.1 - 2.3e-16 60.4 0.5 5.5e-16 59.1 0.3 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CMS1 PF14617.1 ESS61661.1 - 0.26 10.3 7.4 0.3 10.1 5.2 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Mpp10 PF04006.7 ESS61661.1 - 3.8 5.7 11.5 3.8 5.7 8.0 1.3 1 0 0 1 1 1 0 Mpp10 protein Peptidase_A21 PF03566.8 ESS61661.1 - 8.5 4.3 11.2 8.3 4.3 7.7 1.1 1 0 0 1 1 1 0 Peptidase family A21 BNR_3 PF13859.1 ESS61667.1 - 2.4e-30 105.7 0.9 5.2e-30 104.5 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61667.1 - 3.5e-16 59.8 0.3 8e-16 58.6 0.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61667.1 - 8.9e-10 38.2 12.3 1.8e-09 37.2 8.5 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS61669.1 - 1.9e-106 356.2 0.0 1.9e-106 356.2 0.0 1.9 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS61669.1 - 0.0048 16.3 0.1 0.9 8.9 0.0 2.4 2 0 0 2 2 2 2 AAA-like domain BNR_3 PF13859.1 ESS61670.1 - 1.7e-12 47.0 0.0 1.9e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS61671.1 - 4.7e-25 88.2 0.7 7.8e-25 87.5 0.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Dynein_heavy PF03028.10 ESS61671.1 - 0.057 11.4 0.0 0.077 11.0 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor DGF-1_5 PF11038.3 ESS61674.1 - 5.5e-163 540.8 19.1 5.5e-163 540.8 13.2 2.9 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS61674.1 - 2.7e-47 158.5 0.8 2.7e-47 158.5 0.6 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS61674.1 - 1e-38 131.5 16.6 3.4e-38 129.8 11.5 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DUF3728 PF12528.3 ESS61675.1 - 1.2 9.5 5.8 23 5.4 1.4 2.6 2 0 0 2 2 2 0 Prepilin peptidase dependent protein C (DUF3728) MAP65_ASE1 PF03999.7 ESS61676.1 - 1.5 7.2 8.3 2 6.9 5.7 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Tr-sialidase_C PF11052.3 ESS61680.1 - 1e-07 31.6 4.1 2.3e-07 30.5 2.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal TAFII55_N PF04658.8 ESS61681.1 - 0.09 12.2 0.6 0.1 12.0 0.4 1.1 1 0 0 1 1 1 0 TAFII55 protein conserved region Activin_recp PF01064.18 ESS61681.1 - 0.12 13.0 2.9 0.14 12.8 2.0 1.1 1 0 0 1 1 1 0 Activin types I and II receptor domain CWC25 PF12542.3 ESS61681.1 - 0.14 12.6 1.5 0.17 12.3 1.0 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor Mucin PF01456.12 ESS61681.1 - 0.94 9.2 5.1 1.1 9.0 3.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein BRF1 PF07741.8 ESS61681.1 - 1.3 9.2 4.4 1.5 9.0 3.1 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Laminin_G_3 PF13385.1 ESS61682.1 - 7.6e-17 61.9 0.0 1.8e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61682.1 - 5.9e-11 42.0 11.8 5.9e-11 42.0 8.2 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61683.1 - 1.5e-123 411.7 6.3 1.9e-123 411.4 4.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS61683.1 - 0.0052 16.1 0.0 0.011 14.9 0.0 1.7 1 1 1 2 2 2 1 BNR repeat-like domain DUF3357 PF11837.3 ESS61683.1 - 0.046 13.5 0.1 0.55 10.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) NTP_transferase PF00483.18 ESS61685.1 - 1.5e-46 158.7 0.0 1.8e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 ESS61685.1 - 1e-12 48.4 0.0 1.4e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 ESS61685.1 - 4.8e-11 41.6 7.1 2.9e-08 32.8 1.3 3.4 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESS61685.1 - 0.0082 15.6 0.6 0.0082 15.6 0.4 2.8 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.14 ESS61685.1 - 0.031 13.8 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase IspD PF01128.14 ESS61685.1 - 0.1 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase DUF1767 PF08585.7 ESS61686.1 - 6.7e-16 58.3 0.0 1.2e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1767) Tropomyosin_1 PF12718.2 ESS61687.1 - 0.0021 17.8 8.6 0.0021 17.8 5.9 4.3 2 1 2 4 4 4 1 Tropomyosin like Alkyl_sulf_C PF14864.1 ESS61687.1 - 0.049 13.6 0.1 0.049 13.6 0.1 3.8 2 1 1 5 5 5 0 Alkyl sulfatase C-terminal Reo_sigmaC PF04582.7 ESS61687.1 - 0.73 8.9 18.9 0.016 14.4 3.6 3.1 1 1 3 4 4 4 0 Reovirus sigma C capsid protein Arginase PF00491.16 ESS61688.1 - 3.1e-36 125.0 0.0 4.1e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Arginase family Pro_isomerase PF00160.16 ESS61689.1 - 1e-46 158.9 0.0 1.6e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Adeno_PIX PF03955.9 ESS61689.1 - 0.2 12.1 0.6 0.32 11.5 0.4 1.3 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Atg14 PF10186.4 ESS61689.1 - 0.37 9.6 3.6 0.47 9.3 2.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 M_domain PF12938.2 ESS61689.1 - 0.57 9.9 2.8 5.5 6.7 0.1 2.1 1 1 0 2 2 2 0 M domain of GW182 APG6 PF04111.7 ESS61689.1 - 0.67 8.9 4.1 0.83 8.6 2.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Bap31 PF05529.7 ESS61689.1 - 5.8 6.3 8.0 8.1 5.8 5.6 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like AhpC-TSA PF00578.16 ESS61690.1 - 2e-38 130.8 0.0 3.4e-38 130.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESS61690.1 - 1.2e-15 57.2 0.0 2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 ESS61690.1 - 5.3e-10 38.7 0.0 1e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin OKR_DC_1_C PF03711.10 ESS61690.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain YMF19 PF02326.10 ESS61690.1 - 0.27 11.8 3.4 0.63 10.6 2.3 1.6 1 0 0 1 1 1 0 Plant ATP synthase F0 UTP15_C PF09384.5 ESS61691.1 - 1.5e-35 122.0 1.4 1.5e-35 122.0 0.9 1.7 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.27 ESS61691.1 - 1.2e-19 69.3 0.7 0.00019 21.1 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Luciferase_N PF05295.6 ESS61693.1 - 0.095 12.5 0.0 0.29 10.9 0.0 1.8 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain DUF445 PF04286.7 ESS61693.1 - 0.22 11.0 3.4 0.58 9.6 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF445) TraH PF06122.6 ESS61693.1 - 0.42 9.3 4.7 0.2 10.4 0.8 2.0 2 0 0 2 2 2 0 Conjugative relaxosome accessory transposon protein DNA_pol_viral_C PF00336.13 ESS61694.1 - 0.0027 17.0 0.0 0.0096 15.2 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase (viral) C-terminal domain RHSP PF07999.6 ESS61695.1 - 9.7e-36 123.2 2.0 1.8e-35 122.4 1.4 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein FcoT PF10862.3 ESS61695.1 - 0.14 11.7 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 FcoT-like thioesterase domain DGF-1_C PF11040.3 ESS61696.1 - 4.2e-45 151.5 1.1 7.8e-45 150.6 0.7 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SCFA_trans PF02667.9 ESS61696.1 - 0.002 16.9 0.4 0.0027 16.5 0.3 1.2 1 0 0 1 1 1 1 Short chain fatty acid transporter DUF3488 PF11992.3 ESS61696.1 - 3.3 6.2 8.7 5.5 5.5 6.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) DGF-1_5 PF11038.3 ESS61697.1 - 1.5e-157 522.9 27.4 3.2e-131 436.6 15.3 3.9 3 1 1 4 4 4 2 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS61697.1 - 4.3e-39 132.7 17.0 1.1e-38 131.4 11.8 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 EF-hand_1 PF00036.27 ESS61701.1 - 1.4e-23 80.3 3.8 5e-11 41.0 0.7 2.1 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 ESS61701.1 - 2.4e-22 78.8 0.7 2.9e-22 78.5 0.5 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS61701.1 - 2.5e-19 68.6 4.2 3.7e-17 61.6 0.5 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS61701.1 - 1.4e-16 58.8 0.4 8.4e-10 37.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 ESS61701.1 - 3.9e-16 57.5 0.7 4.7e-08 32.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EFhand_Ca_insen PF08726.5 ESS61701.1 - 4.5e-06 26.5 0.2 6.7e-06 25.9 0.2 1.4 1 1 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_4 PF12763.2 ESS61701.1 - 5.3e-06 26.1 0.3 6.4e-06 25.8 0.2 1.0 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 ESS61701.1 - 3.3e-05 23.7 0.0 3.8e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.4 ESS61701.1 - 0.00011 22.2 0.1 0.00013 22.0 0.0 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_like PF09279.6 ESS61701.1 - 0.00028 20.8 0.2 0.00038 20.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like UPF0154 PF03672.8 ESS61701.1 - 0.0036 16.8 0.2 0.044 13.4 0.0 2.3 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) CMD PF02627.15 ESS61701.1 - 0.12 12.2 0.1 1.6 8.6 0.0 2.0 1 1 1 2 2 2 0 Carboxymuconolactone decarboxylase family KIP1 PF07765.7 ESS61701.1 - 0.2 11.4 0.6 3.3 7.5 0.0 2.1 1 1 1 2 2 2 0 KIP1-like protein Dockerin_1 PF00404.13 ESS61701.1 - 2.1 8.1 6.1 2.5 7.9 1.5 2.3 2 0 0 2 2 2 0 Dockerin type I repeat FbpA PF05833.6 ESS61702.1 - 4e-30 104.7 15.6 4e-30 104.7 10.8 3.5 2 2 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.3 ESS61702.1 - 5.9e-23 80.6 0.1 6.8e-22 77.1 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 ESS61702.1 - 6.3e-06 25.9 0.0 0.00016 21.4 0.0 2.8 1 1 0 1 1 1 1 Domain of unknown function (DUF814) DUF1180 PF06679.7 ESS61702.1 - 3.4 7.5 6.1 7.4 6.4 4.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SLA_LP_auto_ag PF05889.8 ESS61703.1 - 1.4e-92 310.2 0.0 3.9e-52 177.0 0.0 3.3 2 2 0 2 2 2 2 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Beta_elim_lyase PF01212.16 ESS61703.1 - 0.0051 15.9 0.1 0.008 15.3 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase IF-2 PF11987.3 ESS61704.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Translation-initiation factor 2 LolB PF03550.9 ESS61706.1 - 0.029 13.9 0.6 0.038 13.5 0.4 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein LolB BNR_3 PF13859.1 ESS61707.1 - 1.6e-64 217.9 1.1 1.6e-64 217.9 0.7 2.1 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61707.1 - 2e-13 50.8 0.1 6.8e-13 49.1 0.0 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4094 PF13334.1 ESS61708.1 - 0.084 13.2 0.5 1.5 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) BNR_3 PF13859.1 ESS61710.1 - 6.1e-134 445.9 4.9 1.2e-133 444.9 3.4 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Ion_trans PF00520.26 ESS61711.1 - 0.044 13.0 1.7 0.056 12.6 1.2 1.1 1 0 0 1 1 1 0 Ion transport protein DUF3720 PF12517.3 ESS61712.1 - 1.5e-16 60.8 13.6 1.5e-16 60.8 9.4 2.8 2 1 0 3 3 3 1 Protein of unknown function (DUF3720) Herpes_TAF50 PF03326.8 ESS61713.1 - 1.5 7.7 6.3 1.5 7.6 4.4 1.0 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) PAT1 PF09770.4 ESS61714.1 - 8.8 4.4 38.9 11 4.0 27.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tr-sialidase_C PF11052.3 ESS61715.1 - 2.1e-07 30.6 6.4 9.2e-07 28.6 4.4 2.2 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS61715.1 - 5e-05 23.5 0.0 0.0001 22.5 0.0 1.8 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS61715.1 - 0.0038 16.3 0.0 0.0055 15.8 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Nuc_deoxyrib_tr PF05014.10 ESS61717.1 - 1.5e-07 31.2 0.0 2.8e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase DUF3720 PF12517.3 ESS61718.1 - 1.1e-14 54.9 14.2 1.1e-14 54.9 9.8 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS61721.1 - 7.9e-136 452.1 7.0 1.5e-135 451.2 4.8 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61721.1 - 1.8e-18 67.2 0.1 4.6e-18 65.9 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61721.1 - 6e-11 42.0 10.6 6e-11 42.0 7.3 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61725.1 - 4.7e-79 265.6 0.0 1.1e-78 264.4 0.0 1.7 1 0 0 1 1 1 1 BNR repeat-like domain DUF3676 PF12429.3 ESS61725.1 - 5.8e-45 153.6 9.2 8.9e-45 153.0 6.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) RHSP PF07999.6 ESS61725.1 - 8.3e-21 74.0 0.0 1.4e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein Laminin_G_3 PF13385.1 ESS61725.1 - 1.9e-09 37.9 1.0 1.9e-09 37.9 0.7 2.3 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS61726.1 - 8.6e-31 106.9 0.0 1e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Herpes_DNAp_acc PF04929.7 ESS61727.1 - 4.4 6.1 5.7 5.7 5.7 4.0 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor BNR_3 PF13859.1 ESS61728.1 - 0.00011 21.3 0.0 0.00015 20.9 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF3357 PF11837.3 ESS61728.1 - 0.056 13.2 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Daxx PF03344.10 ESS61729.1 - 0.00018 20.1 38.0 0.00026 19.6 26.3 1.3 1 0 0 1 1 1 1 Daxx Family Nop14 PF04147.7 ESS61729.1 - 0.005 14.8 33.0 0.006 14.5 22.8 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 ESS61729.1 - 0.012 13.6 20.0 0.013 13.5 13.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 ESS61729.1 - 0.4 8.3 17.0 0.42 8.2 11.8 1.1 1 0 0 1 1 1 0 Ycf1 Utp14 PF04615.8 ESS61729.1 - 3.1 5.8 36.5 4 5.4 25.3 1.1 1 0 0 1 1 1 0 Utp14 protein BTV_NS2 PF04514.7 ESS61729.1 - 7.9 5.2 22.6 14 4.4 15.6 1.4 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 U79_P34 PF03064.11 ESS61729.1 - 9 5.7 21.0 19 4.6 14.5 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Mucin PF01456.12 ESS61730.1 - 2.4e-23 82.5 35.0 2.9e-23 82.2 24.3 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS61730.1 - 0.069 13.0 0.1 0.092 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) TraV PF09676.5 ESS61730.1 - 0.3 11.7 5.4 0.34 11.6 3.7 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Menin PF05053.8 ESS61730.1 - 0.52 8.4 5.6 0.53 8.3 3.9 1.0 1 0 0 1 1 1 0 Menin DUF2413 PF10310.4 ESS61730.1 - 1.4 7.6 5.8 1.4 7.6 4.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Lamp PF01299.12 ESS61730.1 - 9.7 5.2 12.7 12 4.9 8.8 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) BNR_3 PF13859.1 ESS61732.1 - 7.9e-128 425.8 8.1 8.3e-128 425.7 4.5 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61732.1 - 1.7e-16 60.8 0.2 4.3e-16 59.5 0.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61732.1 - 1.3e-10 40.9 13.1 1.3e-10 40.9 9.1 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61736.1 - 9.6e-24 84.0 0.6 1.3e-23 83.5 0.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Herpes_UL20 PF04544.7 ESS61736.1 - 0.15 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus egress protein UL20 BNR_3 PF13859.1 ESS61737.1 - 1.9e-92 309.6 2.5 1.9e-92 309.6 1.8 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61737.1 - 2.5e-19 70.0 1.8 6.1e-19 68.7 1.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS61741.1 - 9e-129 428.9 3.5 9e-129 428.9 2.4 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61741.1 - 1.7e-16 60.8 1.1 1.7e-16 60.8 0.7 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61741.1 - 7.4e-09 35.3 8.0 7.4e-09 35.3 5.5 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS61744.1 - 2.3e-15 56.6 14.2 2.3e-15 56.6 9.9 4.7 3 2 2 5 5 5 1 Mucin-like glycoprotein DUF605 PF04652.11 ESS61746.1 - 0.52 9.6 12.5 0.62 9.3 8.6 1.3 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 ESS61746.1 - 6.2 6.6 7.5 8 6.2 5.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BNR_3 PF13859.1 ESS61748.1 - 2.8e-130 433.9 4.3 2.8e-130 433.9 3.0 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61748.1 - 1.1e-18 68.0 0.9 2.6e-18 66.7 0.7 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61748.1 - 8.5e-11 41.5 6.4 2.2e-10 40.2 4.4 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS61750.1 - 8.7e-36 122.8 65.4 8e-25 87.2 22.2 2.7 2 1 0 2 2 2 2 Mucin-like glycoprotein Tim54 PF11711.3 ESS61750.1 - 7 5.1 13.8 1.5 7.3 1.0 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Pox_P21 PF05313.7 ESS61751.1 - 0.15 11.2 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P21 membrane protein HTH_19 PF12844.2 ESS61752.1 - 0.2 11.7 1.9 0.26 11.3 1.3 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Laminin_G_3 PF13385.1 ESS61754.1 - 1.7e-09 38.0 0.0 3.4e-09 37.1 0.0 1.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61754.1 - 8.6e-08 31.9 9.1 8.6e-08 31.9 6.3 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal WD40 PF00400.27 ESS61756.1 - 1.1e-05 25.0 0.2 0.032 14.1 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat RtcB PF01139.12 ESS61757.1 - 2.2e-120 402.5 0.0 2.5e-120 402.3 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB NifU PF01106.12 ESS61759.1 - 1.1e-16 60.3 0.0 1.9e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.6 ESS61759.1 - 8.7e-11 41.2 0.0 4.8e-09 35.7 0.0 2.4 2 0 0 2 2 2 2 Scaffold protein Nfu/NifU N terminal LRR_4 PF12799.2 ESS61761.1 - 4.6e-28 96.3 24.4 0.018 14.6 0.4 11.9 6 3 3 11 11 11 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS61761.1 - 3.4e-12 45.9 30.0 0.014 15.1 0.2 9.6 6 3 6 12 12 12 7 Leucine rich repeat LRR_6 PF13516.1 ESS61761.1 - 3.6e-07 29.5 35.2 0.0067 16.3 0.0 12.5 15 0 0 15 15 15 3 Leucine Rich repeat LRR_7 PF13504.1 ESS61761.1 - 0.019 15.0 40.1 0.73 10.2 0.2 14.2 15 4 2 17 17 17 0 Leucine rich repeat LRR_1 PF00560.28 ESS61761.1 - 0.096 12.7 40.2 0.18 11.9 0.2 11.6 13 2 0 13 13 13 0 Leucine Rich Repeat ThiF PF00899.16 ESS61762.1 - 7.3e-30 103.5 0.0 1.2e-29 102.8 0.0 1.4 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 ESS61762.1 - 8.7e-07 29.1 0.0 0.00018 21.5 0.0 2.8 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 ESS61762.1 - 0.0031 16.4 0.0 0.0048 15.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase B5 PF03484.10 ESS61762.1 - 0.033 14.0 0.0 0.07 12.9 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase B5 domain 2-Hacid_dh_C PF02826.14 ESS61762.1 - 0.066 12.3 0.0 3.6 6.6 0.0 2.3 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_deac_1 PF01522.16 ESS61762.1 - 0.1 12.2 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide deacetylase ApbA PF02558.11 ESS61762.1 - 0.2 11.1 0.0 0.38 10.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FYVE_2 PF02318.11 ESS61763.1 - 9.8e-05 22.2 1.0 0.00013 21.8 0.7 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger zf-ribbon_3 PF13248.1 ESS61763.1 - 0.0042 16.2 0.5 0.0042 16.2 0.3 4.1 4 1 1 5 5 5 1 zinc-ribbon domain FYVE PF01363.16 ESS61763.1 - 0.0097 15.7 11.9 0.11 12.3 8.5 2.0 1 1 1 2 2 2 1 FYVE zinc finger zinc_ribbon_2 PF13240.1 ESS61763.1 - 0.055 12.9 0.6 0.055 12.9 0.4 4.0 3 2 0 3 3 3 0 zinc-ribbon domain DZR PF12773.2 ESS61763.1 - 0.85 9.4 16.1 40 4.1 11.2 2.6 1 1 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.17 ESS61763.1 - 1.8 8.3 10.8 0.41 10.3 5.3 1.6 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ADK_lid PF05191.9 ESS61763.1 - 3.6 7.3 9.0 0.87 9.3 3.1 2.2 2 1 0 2 2 2 0 Adenylate kinase, active site lid UEV PF05743.8 ESS61764.1 - 1.6e-14 53.6 0.0 2.8e-13 49.6 0.0 2.1 2 0 0 2 2 2 1 UEV domain zf-C3HC4_3 PF13920.1 ESS61764.1 - 1.3e-09 37.5 13.2 3.9e-09 36.0 9.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Mucin PF01456.12 ESS61765.1 - 3.5e-26 91.7 36.5 3.8e-26 91.5 25.3 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein TraV PF09676.5 ESS61765.1 - 0.54 10.9 6.9 0.62 10.7 4.8 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DUF4658 PF15555.1 ESS61765.1 - 1.5 8.7 3.7 5 7.0 2.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) AJAP1_PANP_C PF15298.1 ESS61765.1 - 1.6 8.5 16.8 2.2 8.1 11.6 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Menin PF05053.8 ESS61765.1 - 3.4 5.7 5.0 3.5 5.6 3.4 1.0 1 0 0 1 1 1 0 Menin MGC-24 PF05283.6 ESS61765.1 - 3.5 7.3 20.8 4 7.1 14.4 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) DUF572 PF04502.8 ESS61765.1 - 3.5 6.7 6.4 3.8 6.6 4.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lamp PF01299.12 ESS61765.1 - 6.5 5.8 14.2 7.7 5.5 9.9 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Daxx PF03344.10 ESS61766.1 - 2.3 6.5 13.2 3 6.2 9.2 1.1 1 0 0 1 1 1 0 Daxx Family Exo_endo_phos PF03372.18 ESS61768.1 - 0.0093 15.9 0.0 0.014 15.3 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3068 PF11271.3 ESS61769.1 - 1 8.3 7.8 0.49 9.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3068) RVT_1 PF00078.22 ESS61771.1 - 2e-12 46.9 0.0 2.6e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_ASH PF10554.4 ESS61771.1 - 0.012 15.9 0.0 0.022 15.0 0.0 1.5 1 1 0 1 1 1 0 Ash protein family BNR_3 PF13859.1 ESS61774.1 - 2.9e-129 430.5 5.7 5.3e-129 429.7 3.9 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61774.1 - 2.9e-17 63.3 2.0 6.8e-17 62.1 1.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61774.1 - 1.1e-09 38.0 10.4 2.3e-09 36.9 7.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2_4 PF13894.1 ESS61777.1 - 0.041 14.2 1.6 0.1 12.9 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS61777.1 - 0.24 11.8 3.7 0.27 11.6 0.3 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF966 PF06136.8 ESS61778.1 - 6.2 6.1 12.7 8.8 5.6 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Mucin PF01456.12 ESS61781.1 - 0.00015 21.5 6.3 0.00015 21.5 4.3 3.8 3 1 1 4 4 4 1 Mucin-like glycoprotein BNR_3 PF13859.1 ESS61783.1 - 5.2e-77 258.9 1.3 5.2e-77 258.9 0.9 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61783.1 - 3.1e-18 66.4 0.8 7.1e-18 65.3 0.6 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61783.1 - 1.4e-10 40.8 6.8 3e-10 39.7 4.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Glycos_transf_2 PF00535.21 ESS61784.1 - 0.00017 21.3 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS61784.1 - 0.0023 17.0 0.0 0.2 10.6 0.1 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESS61784.1 - 0.054 13.1 0.6 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase family group 2 HAUS4 PF14735.1 ESS61784.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Glycos_transf_2 PF00535.21 ESS61785.1 - 0.00035 20.3 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS61785.1 - 0.0081 15.2 0.0 0.41 9.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 HAUS4 PF14735.1 ESS61785.1 - 0.039 13.2 0.0 0.056 12.7 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Glyco_trans_2_3 PF13632.1 ESS61785.1 - 0.055 13.1 0.4 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase family group 2 RVT_3 PF13456.1 ESS61786.1 - 0.008 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like Sp38 PF07354.7 ESS61788.1 - 0.046 12.3 0.2 0.11 11.1 0.1 1.6 1 1 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) RHSP PF07999.6 ESS61789.1 - 5.7e-98 328.3 0.5 7.7e-98 327.9 0.4 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61789.1 - 0.0016 18.5 0.0 2.2 8.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain DAP3 PF10236.4 ESS61789.1 - 0.022 13.7 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_10 PF12846.2 ESS61789.1 - 0.2 11.0 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain DUF348 PF03990.9 ESS61790.1 - 0.081 12.5 0.1 0.43 10.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF348) DUF2890 PF11081.3 ESS61793.1 - 0.11 12.5 3.3 0.13 12.2 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Bac_small_YrzI PF09501.5 ESS61793.1 - 0.33 10.8 2.0 2.6 8.0 0.0 2.2 1 1 1 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) Mucin PF01456.12 ESS61794.1 - 1e-36 125.8 34.6 1e-36 125.8 24.0 3.0 2 1 0 2 2 2 1 Mucin-like glycoprotein SpoIIIAH PF12685.2 ESS61794.1 - 2.6 7.4 7.8 51 3.2 5.4 2.1 1 1 0 1 1 1 0 SpoIIIAH-like protein DUF3123 PF11321.3 ESS61794.1 - 2.8 8.2 7.2 15 5.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) DUF3720 PF12517.3 ESS61795.1 - 1.1e-22 80.4 16.1 1.1e-22 80.4 11.1 4.2 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) Utp14 PF04615.8 ESS61795.1 - 2.7 6.0 46.6 3.5 5.6 32.3 1.1 1 0 0 1 1 1 0 Utp14 protein BNR_3 PF13859.1 ESS61796.1 - 8.4e-44 149.8 0.3 1e-43 149.6 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61797.1 - 6.3e-13 49.2 0.3 6.3e-13 49.2 0.2 2.0 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61797.1 - 1.2e-09 37.8 9.7 3e-09 36.5 6.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3487 PF11990.3 ESS61798.1 - 4.5 6.6 5.5 1.9 7.8 2.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) Daxx PF03344.10 ESS61799.1 - 0.081 11.3 19.5 0.1 11.0 13.5 1.2 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESS61799.1 - 2.6 5.9 8.0 2.8 5.8 5.6 1.3 1 0 0 1 1 1 0 CDC45-like protein BNR_3 PF13859.1 ESS61801.1 - 4.4e-63 213.2 1.1 1e-62 212.0 0.1 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61801.1 - 2.8e-16 60.1 0.6 2.8e-16 60.1 0.4 2.3 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61801.1 - 8.8e-11 41.4 11.1 1.8e-10 40.4 7.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3548 PF12068.3 ESS61801.1 - 0.082 12.1 0.1 0.21 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3548) RHSP PF07999.6 ESS61802.1 - 1.6e-78 264.2 0.0 2.4e-78 263.7 0.0 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61802.1 - 0.073 13.2 0.2 0.25 11.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain BNR_3 PF13859.1 ESS61803.1 - 3.3e-57 193.9 0.1 5.5e-57 193.1 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61803.1 - 9.3e-05 22.7 0.2 0.00061 20.0 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS61803.1 - 0.00018 20.8 0.1 0.00062 19.1 0.0 1.9 1 1 0 2 2 2 1 BNR repeat-like domain BNR PF02012.15 ESS61803.1 - 2 8.5 7.4 8.2 6.7 0.5 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat RHSP PF07999.6 ESS61804.1 - 9.9e-94 314.3 0.4 1.6e-93 313.7 0.3 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61804.1 - 0.058 13.5 0.0 0.69 10.0 0.0 2.5 1 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESS61804.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain BNR_3 PF13859.1 ESS61805.1 - 1.3e-63 214.9 0.1 2.6e-63 213.9 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61805.1 - 9.9e-14 51.8 0.4 3.8e-13 49.9 0.0 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61805.1 - 4.5e-08 32.8 8.7 1.3e-07 31.3 6.1 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS61805.1 - 0.0001 21.5 1.9 0.59 10.1 0.1 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat RHSP PF07999.6 ESS61808.1 - 8.3e-45 153.1 0.0 9e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS61809.1 - 9.6e-132 438.7 4.9 9.6e-132 438.7 3.4 2.0 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61809.1 - 4.7e-14 52.9 2.0 1.4e-13 51.4 0.0 2.8 4 0 0 4 4 4 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61809.1 - 4.8e-10 39.1 12.4 9.5e-10 38.1 8.6 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61812.1 - 7.7e-131 435.7 1.6 7.7e-131 435.7 1.1 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61812.1 - 1.8e-18 67.2 1.9 1.8e-18 67.2 1.3 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61812.1 - 3.8e-10 39.4 12.4 8.9e-10 38.2 8.6 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61815.1 - 4.8e-131 436.4 5.3 5.1e-131 436.3 2.8 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61815.1 - 4.1e-15 56.3 1.3 1.1e-14 54.9 0.2 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61815.1 - 9e-10 38.2 12.4 9e-10 38.2 8.6 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Exo_endo_phos_2 PF14529.1 ESS61816.1 - 1.1e-17 63.7 0.0 1.8e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS61816.1 - 8.7e-06 25.8 0.1 1.7e-05 24.8 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Laminin_G_3 PF13385.1 ESS61820.1 - 1.1e-15 58.2 0.1 1.6e-15 57.7 0.1 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61820.1 - 6.1e-08 32.3 11.9 6.1e-08 32.3 8.3 1.7 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS61821.1 - 2e-102 342.4 2.9 2e-102 342.4 2.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain DUF2721 PF11026.3 ESS61823.1 - 0.045 13.4 3.3 0.06 12.9 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF4191 PF13829.1 ESS61823.1 - 0.18 10.9 1.9 0.21 10.6 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF3040 PF11239.3 ESS61823.1 - 0.56 10.2 11.1 0.9 9.6 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF1700 PF08006.6 ESS61823.1 - 2.1 7.5 4.9 2.4 7.4 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) SUR7 PF06687.7 ESS61823.1 - 3.9 6.9 13.9 3.7 7.0 5.2 2.0 1 1 1 2 2 2 0 SUR7/PalI family DUF3720 PF12517.3 ESS61824.1 - 1.1e-18 67.6 14.8 1.1e-18 67.6 10.3 3.6 2 1 1 3 3 3 1 Protein of unknown function (DUF3720) C6_DPF PF10170.4 ESS61827.1 - 0.06 13.4 0.2 0.12 12.4 0.2 1.5 1 0 0 1 1 1 0 Cysteine-rich domain RHSP PF07999.6 ESS61828.1 - 1.9e-90 303.6 2.4 2.3e-90 303.3 1.7 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS61828.1 - 0.045 13.8 0.0 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.4 ESS61828.1 - 0.072 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF605 PF04652.11 ESS61829.1 - 0.11 11.8 14.5 0.12 11.8 10.0 1.1 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 ESS61829.1 - 3.7 5.6 15.3 3.9 5.5 10.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BNR_3 PF13859.1 ESS61831.1 - 5e-45 153.8 0.0 6.6e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS61832.1 - 2.5e-115 385.5 2.9 1.1e-114 383.4 0.0 2.2 2 0 0 2 2 2 2 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS61833.1 - 5.6e-161 534.2 16.3 2.4e-160 532.1 11.3 2.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS61833.1 - 4.1e-39 132.7 20.0 1.3e-38 131.2 13.9 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS61833.1 - 2.3e-17 62.6 3.6 2.3e-17 62.6 2.5 2.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SID-1_RNA_chan PF13965.1 ESS61833.1 - 5.7 4.9 4.8 8.7 4.3 3.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BNR_3 PF13859.1 ESS61838.1 - 1.3e-89 300.3 0.2 2.1e-61 207.7 0.0 2.5 1 1 1 2 2 2 2 BNR repeat-like domain CusF_Ec PF11604.3 ESS61838.1 - 0.11 12.4 0.0 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Copper binding periplasmic protein CusF ECH PF00378.15 ESS61839.1 - 5.8e-53 179.5 0.0 7.5e-53 179.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family DUF3549 PF12069.3 ESS61839.1 - 0.037 12.8 0.1 0.055 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3549) Peptidase_M1 PF01433.15 ESS61840.1 - 1.4e-16 60.6 0.0 1.7e-10 40.5 0.0 2.7 3 0 0 3 3 3 2 Peptidase family M1 Peptidase_MA_2 PF13485.1 ESS61840.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Hydrolase_6 PF13344.1 ESS61841.1 - 9.2e-19 67.2 0.0 1.8e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESS61841.1 - 1.3e-13 50.3 0.0 3e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ESS61841.1 - 3.7e-07 30.7 0.0 0.0036 17.7 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 ESS61841.1 - 8.3e-05 21.9 0.0 0.00029 20.2 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase HAD_2 PF13419.1 ESS61841.1 - 0.00095 19.4 0.0 0.0037 17.5 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Symplekin_C PF12295.3 ESS61842.1 - 0.00023 21.1 0.0 0.003 17.4 0.0 2.8 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal WD40 PF00400.27 ESS61844.1 - 1.2e-06 28.1 0.1 0.29 11.0 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESS61844.1 - 0.16 10.7 0.0 0.27 9.9 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region Cation_efflux PF01545.16 ESS61845.1 - 7.1e-57 192.6 6.5 9.1e-57 192.2 4.5 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ESS61845.1 - 0.00019 20.5 2.4 0.00019 20.5 1.6 1.7 2 0 0 2 2 2 1 ZIP Zinc transporter Lipase_3 PF01764.20 ESS61847.1 - 1e-36 125.6 0.0 1.4e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESS61847.1 - 0.0012 18.2 0.3 0.0092 15.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.2 ESS61847.1 - 0.0015 18.4 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS61847.1 - 0.0023 17.7 0.0 0.0042 16.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 ESS61847.1 - 0.0039 16.5 0.0 0.0054 16.0 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF2048 PF09752.4 ESS61847.1 - 0.0099 14.7 0.3 0.014 14.2 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2048) DUF3825 PF12873.2 ESS61847.1 - 0.13 11.3 0.0 0.36 9.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3825) Abhydrolase_1 PF00561.15 ESS61847.1 - 0.16 11.5 0.3 0.3 10.6 0.2 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Exo_endo_phos_2 PF14529.1 ESS61848.1 - 2.9e-08 33.3 0.0 4.6e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS61848.1 - 2.2e-07 31.0 0.0 2.9e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BNR_3 PF13859.1 ESS61852.1 - 1.2e-133 444.9 4.2 2.7e-133 443.8 2.9 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61852.1 - 2.5e-17 63.5 0.8 8.4e-17 61.8 0.6 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61852.1 - 3e-11 42.9 11.1 6.9e-11 41.8 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DapB_C PF05173.9 ESS61852.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus FA PF08736.6 ESS61853.1 - 0.23 11.2 1.1 0.38 10.5 0.8 1.4 1 0 0 1 1 1 0 FERM adjacent (FA) PAT1 PF09770.4 ESS61855.1 - 9.8 4.2 35.7 12 4.0 24.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RuvA_C PF07499.8 ESS61861.1 - 0.059 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 RuvA, C-terminal domain YABBY PF04690.8 ESS61862.1 - 0.015 15.5 0.1 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 YABBY protein BNR_3 PF13859.1 ESS61863.1 - 1.4e-129 431.6 6.6 1.4e-129 431.6 4.6 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61863.1 - 2.2e-18 66.9 1.0 4e-18 66.1 0.1 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61863.1 - 5.5e-09 35.7 10.5 1.5e-08 34.3 7.3 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M8 PF01457.11 ESS61865.1 - 2.8e-08 32.5 3.5 2e-06 26.4 2.4 2.0 1 1 0 1 1 1 1 Leishmanolysin Exo_endo_phos_2 PF14529.1 ESS61867.1 - 3.4e-11 42.8 0.1 5.4e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS61867.1 - 1.3e-08 35.1 0.1 2.8e-08 34.0 0.1 1.5 1 1 1 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Chon_Sulph_att PF06566.6 ESS61871.1 - 0.067 12.8 5.0 0.078 12.6 3.5 1.0 1 0 0 1 1 1 0 Chondroitin sulphate attachment domain Kei1 PF08552.6 ESS61871.1 - 0.36 10.4 4.8 0.46 10.1 3.3 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 RR_TM4-6 PF06459.7 ESS61871.1 - 1.4 8.7 8.6 1.5 8.6 6.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YqfQ PF14181.1 ESS61871.1 - 6.2 6.8 6.5 7.7 6.5 4.5 1.2 1 0 0 1 1 1 0 YqfQ-like protein BNR_3 PF13859.1 ESS61872.1 - 2.6e-129 430.7 6.2 2.6e-129 430.7 4.3 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61872.1 - 1.1e-19 71.2 1.0 3.2e-19 69.7 0.7 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61872.1 - 4.5e-09 36.0 9.2 4.5e-09 36.0 6.4 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS61874.1 - 9e-43 145.4 47.0 2.9e-25 88.7 24.1 2.0 1 1 1 2 2 2 2 Mucin-like glycoprotein DUF4366 PF14283.1 ESS61874.1 - 0.0014 18.0 0.4 0.0014 18.0 0.2 2.7 1 1 0 2 2 2 1 Domain of unknown function (DUF4366) DUF3811 PF11656.3 ESS61874.1 - 1 9.4 9.4 1.9 8.5 6.5 1.5 1 0 0 1 1 1 0 YjbD family (DUF3811) PA26 PF04636.8 ESS61874.1 - 1.9 7.0 5.7 2.3 6.7 3.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) MGC-24 PF05283.6 ESS61874.1 - 3.8 7.2 33.5 7.3 6.3 23.2 1.4 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Ctr PF04145.10 ESS61874.1 - 9.9 6.2 6.2 19 5.3 0.0 2.2 1 1 1 2 2 2 0 Ctr copper transporter family LSM PF01423.17 ESS61875.1 - 1.7e-06 27.4 0.0 2.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain DUF1314 PF07013.6 ESS61875.1 - 0.14 11.5 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) DUF3350 PF11830.3 ESS61876.1 - 0.09 12.8 0.1 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3350) DUF1186 PF06685.6 ESS61876.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) TarH PF02203.10 ESS61877.1 - 0.018 14.8 0.3 0.037 13.8 0.2 1.4 1 0 0 1 1 1 0 Tar ligand binding domain homologue Glyco_transf_11 PF01531.11 ESS61878.1 - 1.8e-14 53.4 0.2 8e-07 28.3 0.0 2.9 3 0 0 3 3 3 3 Glycosyl transferase family 11 PHD_2 PF13831.1 ESS61879.1 - 0.091 12.0 0.6 0.19 11.0 0.4 1.4 1 0 0 1 1 1 0 PHD-finger BSD PF03909.12 ESS61880.1 - 7.7e-09 35.1 0.0 2.7e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 BSD domain RP-C_C PF11800.3 ESS61880.1 - 0.25 11.0 2.7 0.44 10.2 1.8 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Kinesin PF00225.18 ESS61881.1 - 1.4e-90 303.3 0.0 2.2e-90 302.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Exo_endo_phos PF03372.18 ESS61882.1 - 8.6e-12 45.5 0.1 1.3e-11 44.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HTH_Tnp_IS1 PF12759.2 ESS61882.1 - 0.057 12.8 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 InsA C-terminal domain DUF4239 PF14023.1 ESS61883.1 - 0.21 10.9 0.3 2.5 7.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) Glutaredoxin PF00462.19 ESS61885.1 - 2.7e-17 62.5 0.2 5.8e-17 61.4 0.0 1.6 2 0 0 2 2 2 1 Glutaredoxin SH3BGR PF04908.10 ESS61885.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein Thymidylate_kin PF02223.12 ESS61886.1 - 9.5e-19 67.4 0.0 1.3e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.1 ESS61886.1 - 0.00023 21.4 0.0 0.0006 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS61886.1 - 0.00043 20.1 1.5 0.0019 18.1 1.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS61886.1 - 0.00089 19.4 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS61886.1 - 0.0027 17.7 0.2 0.0064 16.5 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 ESS61886.1 - 0.0035 16.4 0.2 0.011 14.8 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 ESS61886.1 - 0.0066 17.2 0.0 0.0096 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.13 ESS61886.1 - 0.0068 15.4 0.0 0.075 12.0 0.0 2.1 1 1 1 2 2 2 1 6-phosphofructo-2-kinase RNA_helicase PF00910.17 ESS61886.1 - 0.011 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA PF00004.24 ESS61886.1 - 0.032 14.4 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESS61886.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 ESS61886.1 - 0.14 11.9 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) BNR_3 PF13859.1 ESS61888.1 - 2.7e-131 437.2 3.4 2.7e-131 437.2 2.3 2.3 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61888.1 - 2.5e-18 66.8 1.1 2.5e-18 66.8 0.8 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61888.1 - 5.6e-10 38.8 10.4 5.6e-10 38.8 7.2 2.4 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS61888.1 - 0.027 13.4 0.1 0.06 12.3 0.0 1.5 1 0 0 1 1 1 0 Sialidase, N-terminal domain DUF2909 PF11137.3 ESS61888.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Daxx PF03344.10 ESS61893.1 - 0.78 8.1 11.5 1.2 7.5 8.0 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 ESS61893.1 - 5.3 4.8 13.1 7.1 4.4 9.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4088 PF13317.1 ESS61896.1 - 0.064 12.5 0.2 0.72 9.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4088) RHSP PF07999.6 ESS61897.1 - 1.3e-33 116.2 0.0 1.5e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein GBP_C PF02841.9 ESS61900.1 - 0.29 10.2 12.6 0.31 10.1 8.8 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF3597 PF12200.3 ESS61900.1 - 2.7 8.3 9.2 3.4 8.0 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DUF3138 PF11336.3 ESS61900.1 - 6.3 4.8 14.2 7.2 4.6 9.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TFIIA PF03153.8 ESS61901.1 - 0.11 12.3 6.8 0.15 11.9 4.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RHSP PF07999.6 ESS61903.1 - 6e-34 117.3 0.0 7.6e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61904.1 - 9.3e-09 34.3 0.1 1.8e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS61905.1 - 1e-129 432.1 7.5 2e-129 431.1 5.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61905.1 - 1.8e-07 30.8 11.0 1.8e-07 30.8 7.7 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4614 PF15391.1 ESS61906.1 - 0.54 10.0 9.4 1.1 9.0 6.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PAS_6 PF08348.6 ESS61907.1 - 0.89 9.1 3.6 4.3 6.9 2.5 1.9 1 1 0 1 1 1 0 YheO-like PAS domain DUF1637 PF07847.7 ESS61908.1 - 0.051 12.9 3.4 0.077 12.3 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1637) Peptidase_M8 PF01457.11 ESS61910.1 - 6.3e-84 282.1 10.6 7.4e-83 278.6 7.4 1.9 1 1 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESS61910.1 - 0.047 13.4 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 Matrixin DUF3810 PF12725.2 ESS61910.1 - 0.15 10.9 0.0 0.26 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) zf-C2H2_6 PF13912.1 ESS61914.1 - 0.0059 16.4 1.0 0.25 11.3 0.0 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESS61914.1 - 0.014 15.6 2.1 1.9 9.0 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS61914.1 - 0.13 12.6 3.1 1 9.8 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Zn_Tnp_IS1 PF03811.8 ESS61914.1 - 0.19 11.2 4.7 0.75 9.3 0.3 2.9 2 1 0 2 2 2 0 InsA N-terminal domain MIP-T3 PF10243.4 ESS61915.1 - 4.1 5.7 28.1 5 5.4 19.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Macoilin PF09726.4 ESS61915.1 - 9.6 4.3 22.5 14 3.7 15.6 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF4131 PF13567.1 ESS61917.1 - 0.063 12.6 0.5 0.72 9.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Daxx PF03344.10 ESS61917.1 - 0.15 10.5 27.7 0.17 10.3 19.2 1.1 1 0 0 1 1 1 0 Daxx Family Utp14 PF04615.8 ESS61917.1 - 0.86 7.6 31.9 1.1 7.3 22.1 1.0 1 0 0 1 1 1 0 Utp14 protein LAT PF15234.1 ESS61919.1 - 0.0078 15.7 0.2 0.0097 15.4 0.1 1.3 1 0 0 1 1 1 1 Linker for activation of T-cells Nop14 PF04147.7 ESS61919.1 - 0.15 9.9 16.1 0.16 9.8 11.2 1.0 1 0 0 1 1 1 0 Nop14-like family Ndc1_Nup PF09531.5 ESS61919.1 - 2.5 6.3 5.2 2.8 6.2 3.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CytochromB561_N PF09786.4 ESS61919.1 - 2.7 6.3 6.8 3.1 6.1 4.7 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal Ycf1 PF05758.7 ESS61919.1 - 2.9 5.4 12.3 2.8 5.5 8.5 1.0 1 0 0 1 1 1 0 Ycf1 FAM60A PF15396.1 ESS61919.1 - 4.4 6.9 10.2 6.4 6.4 7.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.7 ESS61919.1 - 9.3 6.0 20.0 13 5.5 13.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EBP50_C-term PF09007.6 ESS61920.1 - 0.026 14.3 0.2 0.095 12.5 0.1 1.9 2 0 0 2 2 2 0 EBP50, C-terminal RVT_1 PF00078.22 ESS61921.1 - 1.9e-27 96.0 0.0 2.5e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DGF-1_5 PF11038.3 ESS61922.1 - 5.4e-161 534.2 16.6 5.4e-161 534.2 11.5 2.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS61922.1 - 6.9e-40 135.2 16.6 2e-39 133.8 11.5 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS61922.1 - 2.1e-38 130.0 0.7 7.5e-38 128.2 0.5 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Ribosomal_S30 PF04758.9 ESS61925.1 - 0.033 13.9 1.4 0.045 13.5 0.3 1.7 2 0 0 2 2 2 0 Ribosomal protein S30 Peptidase_M8 PF01457.11 ESS61926.1 - 3.6e-105 352.2 9.1 3.2e-104 349.1 6.3 1.9 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS61926.1 - 9.2e-11 41.4 10.3 9.2e-11 41.4 7.2 2.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS61926.1 - 0.048 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 Matrixin BNR_3 PF13859.1 ESS61928.1 - 8.5e-46 156.4 2.0 1.2e-45 155.9 1.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF3682 PF12446.3 ESS61929.1 - 1.6e-50 170.8 39.5 1.6e-50 170.8 27.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3682) Daxx PF03344.10 ESS61929.1 - 1.3 7.3 14.1 1.7 7.0 9.8 1.1 1 0 0 1 1 1 0 Daxx Family DUF4407 PF14362.1 ESS61929.1 - 1.5 7.7 3.9 2.3 7.1 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.7 ESS61929.1 - 1.7 8.4 8.0 2 8.2 5.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.12 ESS61929.1 - 2.2 7.0 4.0 3 6.5 2.8 1.3 1 0 0 1 1 1 0 Presenilin Plasmodium_Vir PF05795.6 ESS61929.1 - 4.7 6.3 6.0 4.2 6.4 3.6 1.3 1 1 0 1 1 1 0 Plasmodium vivax Vir protein DUF1360 PF07098.6 ESS61930.1 - 0.035 13.8 0.1 0.051 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zf-ribbon_3 PF13248.1 ESS61930.1 - 0.86 8.8 3.7 0.5 9.6 1.0 1.9 2 1 0 2 2 2 0 zinc-ribbon domain BNR_3 PF13859.1 ESS61935.1 - 5e-127 423.2 2.6 5e-127 423.2 1.8 1.9 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS61935.1 - 1.4e-08 34.4 9.1 1.4e-08 34.4 6.3 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS61935.1 - 0.0024 18.1 0.1 0.0099 16.1 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Mo-co_dimer PF03404.11 ESS61935.1 - 0.052 13.1 0.2 6.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Mo-co oxidoreductase dimerisation domain SSB PF00436.20 ESS61937.1 - 0.017 14.9 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Single-strand binding protein family DUF4607 PF15380.1 ESS61937.1 - 0.056 12.8 8.0 0.13 11.7 5.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4607) DUF3720 PF12517.3 ESS61939.1 - 0.00067 20.3 8.0 0.00067 20.3 5.5 3.6 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) RHSP PF07999.6 ESS61942.1 - 4.8e-39 134.1 0.1 5.4e-39 134.0 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein LCE PF14672.1 ESS61943.1 - 0.45 11.0 3.9 0.49 10.9 2.5 1.3 1 1 0 1 1 1 0 Late cornified envelope RseA_N PF03872.8 ESS61944.1 - 0.018 15.3 0.4 0.029 14.6 0.3 1.3 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain Beta-TrCP_D PF12125.3 ESS61945.1 - 0.013 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 D domain of beta-TrCP WD40 PF00400.27 ESS61947.1 - 2.1e-13 49.5 8.7 2.6e-05 23.9 0.2 5.3 5 1 0 5 5 5 3 WD domain, G-beta repeat Ubiq_cyt_C_chap PF03981.7 ESS61948.1 - 0.18 11.6 0.2 1.7 8.4 0.1 2.1 2 0 0 2 2 2 0 Ubiquinol-cytochrome C chaperone DUF421 PF04239.7 ESS61953.1 - 0.044 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF421) TerD PF02342.13 ESS61954.1 - 3.4e-77 257.9 0.0 1.6e-55 187.2 0.0 2.2 2 0 0 2 2 2 2 TerD domain PYST-C1 PF09690.5 ESS61954.1 - 3.4 7.3 8.9 0.11 12.1 1.6 1.9 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) Calreticulin PF00262.13 ESS61955.1 - 2.7e-114 381.6 9.9 2.7e-114 381.6 6.8 1.5 2 0 0 2 2 2 1 Calreticulin family Metallophos_3 PF14582.1 ESS61955.1 - 0.62 9.1 5.4 0.96 8.5 3.7 1.2 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Myosin_tail_1 PF01576.14 ESS61956.1 - 0.01 13.5 11.5 0.014 13.1 6.8 1.8 1 1 0 1 1 1 0 Myosin tail TMCO5 PF14992.1 ESS61956.1 - 0.042 12.9 2.4 0.076 12.1 1.7 1.3 1 0 0 1 1 1 0 TMCO5 family LMP PF04778.7 ESS61956.1 - 0.058 13.1 0.5 0.12 12.0 0.4 1.5 1 0 0 1 1 1 0 LMP repeated region Phage_GP20 PF06810.6 ESS61956.1 - 0.071 12.5 2.7 0.13 11.7 1.9 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 RNA_pol_Rpb1_5 PF04998.12 ESS61957.1 - 2.9e-100 335.0 0.0 5.7e-100 334.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 ESS61957.1 - 4.9e-82 275.8 0.1 1.3e-81 274.5 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 ESS61957.1 - 6.1e-65 218.2 0.1 1.8e-64 216.6 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 ESS61957.1 - 6.4e-43 146.6 0.3 1.3e-42 145.6 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 ESS61957.1 - 1.8e-42 144.7 0.0 4.3e-42 143.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESS61957.1 - 1.2e-27 95.7 0.1 3e-27 94.4 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_7 PF04990.7 ESS61957.1 - 6.1e-27 93.9 0.8 6.1e-27 93.9 0.5 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 Galactosyl_T PF01762.16 ESS61958.1 - 3.7e-09 36.4 0.1 0.0012 18.5 0.0 3.3 2 1 1 3 3 3 3 Galactosyltransferase Galactosyl_T PF01762.16 ESS61959.1 - 1e-09 38.3 0.1 0.0028 17.2 0.0 3.3 2 1 1 3 3 3 3 Galactosyltransferase AATF-Che1 PF13339.1 ESS61960.1 - 0.041 14.0 2.4 0.066 13.3 1.7 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor IncA PF04156.9 ESS61961.1 - 0.91 9.0 6.8 4.3 6.8 0.4 2.8 3 0 0 3 3 3 0 IncA protein AIG1 PF04548.11 ESS61962.1 - 0.41 9.7 3.6 0.65 9.0 2.5 1.3 1 0 0 1 1 1 0 AIG1 family WW PF00397.21 ESS61965.1 - 2.1e-06 27.4 0.2 4.7e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 WW domain ABC2_membrane_3 PF12698.2 ESS61966.1 - 0.6 9.0 4.0 0.91 8.4 2.8 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4634 PF15465.1 ESS61968.1 - 0.15 12.2 0.2 0.29 11.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) Mucin PF01456.12 ESS61973.1 - 0.66 9.7 18.1 1.8 8.3 12.6 2.1 1 1 0 1 1 1 0 Mucin-like glycoprotein TMEM171 PF15471.1 ESS61973.1 - 7.1 5.3 7.0 15 4.2 4.9 1.5 1 0 0 1 1 1 0 Transmembrane protein family 171 Mucin PF01456.12 ESS61979.1 - 0.0032 17.2 3.9 0.0032 17.2 2.7 1.8 2 0 0 2 2 2 1 Mucin-like glycoprotein HTH_11 PF08279.7 ESS61980.1 - 0.1 12.2 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 HTH domain RHSP PF07999.6 ESS61981.1 - 3.4e-30 105.0 0.0 4e-30 104.7 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS61982.1 - 2.8e-11 42.6 0.2 4.6e-11 41.9 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS61985.1 - 1.3e-131 438.3 4.4 1.3e-131 438.3 3.0 1.9 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS61985.1 - 8.7e-17 61.8 0.4 3.3e-16 59.9 0.2 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS61985.1 - 3.7e-09 36.2 9.4 3.7e-09 36.2 6.5 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Tr-sialidase_C PF11052.3 ESS61986.1 - 2.7e-05 23.9 4.0 6.5e-05 22.7 2.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mem_trans PF03547.13 ESS61987.1 - 6.5e-28 97.1 11.2 7.7e-28 96.8 7.8 1.0 1 0 0 1 1 1 1 Membrane transport protein Mem_trans PF03547.13 ESS61988.1 - 2.7e-25 88.4 0.1 9.2e-25 86.7 0.1 1.8 1 1 0 1 1 1 1 Membrane transport protein Methyltransf_18 PF12847.2 ESS61989.1 - 0.0012 19.4 0.1 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS61989.1 - 0.0017 18.0 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS61989.1 - 0.0078 16.6 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 ESS61989.1 - 0.068 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain EAP30 PF04157.11 ESS61990.1 - 1.1e-40 139.1 0.0 1.6e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 ESS61990.1 - 1.5e-20 72.8 0.0 3e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.15 ESS61990.1 - 0.0014 18.0 0.0 0.003 17.0 0.0 1.5 1 0 0 1 1 1 1 GRAM domain WWbp PF10349.4 ESS61990.1 - 0.051 14.4 0.0 0.46 11.3 0.0 2.3 2 0 0 2 2 2 0 WW-domain ligand protein DUF2630 PF10944.3 ESS61990.1 - 0.085 12.9 0.2 0.21 11.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) Prefoldin_2 PF01920.15 ESS61992.1 - 1.6e-05 24.6 25.1 0.0021 17.7 4.6 4.0 4 0 0 4 4 4 2 Prefoldin subunit Laminin_II PF06009.7 ESS61992.1 - 0.00029 20.6 13.6 0.064 13.0 2.3 3.8 1 1 3 4 4 4 3 Laminin Domain II EzrA PF06160.7 ESS61992.1 - 0.00035 18.8 17.1 0.0065 14.7 5.4 2.5 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA MCPsignal PF00015.16 ESS61992.1 - 0.00094 18.7 6.2 0.00094 18.7 4.3 2.2 1 1 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain CENP-F_leu_zip PF10473.4 ESS61992.1 - 0.0032 17.3 25.7 0.097 12.5 5.1 3.2 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG2 PF06148.6 ESS61992.1 - 0.0039 17.0 16.0 1.1 9.1 3.5 4.2 1 1 3 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.6 ESS61992.1 - 0.005 15.5 18.3 0.075 11.6 3.8 2.6 1 1 2 3 3 3 2 Spc7 kinetochore protein ATP-synt_D PF01813.12 ESS61992.1 - 0.0062 16.1 7.5 0.099 12.1 1.0 3.8 1 1 1 2 2 2 1 ATP synthase subunit D DUF948 PF06103.6 ESS61992.1 - 0.0077 16.0 4.3 0.33 10.8 0.4 3.4 1 1 2 3 3 3 1 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.6 ESS61992.1 - 0.012 16.0 17.0 0.013 15.8 2.3 4.1 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Filament PF00038.16 ESS61992.1 - 0.021 14.3 24.3 0.054 12.9 10.3 2.1 1 1 0 2 2 2 0 Intermediate filament protein Herpes_U30 PF04523.8 ESS61992.1 - 0.022 12.2 1.3 0.026 12.0 0.5 1.4 1 1 0 1 1 1 0 Herpes virus tegument protein U30 LOH1CR12 PF10158.4 ESS61992.1 - 0.022 14.5 7.6 0.17 11.7 0.3 3.0 2 1 0 3 3 3 0 Tumour suppressor protein Baculo_PEP_C PF04513.7 ESS61992.1 - 0.023 14.5 9.1 2.9 7.7 3.9 3.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3407 PF11887.3 ESS61992.1 - 0.033 13.4 0.2 0.068 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3407) AAA_13 PF13166.1 ESS61992.1 - 0.035 12.5 13.9 0.017 13.6 7.7 1.6 1 1 0 1 1 1 0 AAA domain KxDL PF10241.4 ESS61992.1 - 0.038 13.9 0.2 0.038 13.9 0.2 3.7 2 2 1 3 3 3 0 Uncharacterized conserved protein NumbF PF06311.7 ESS61992.1 - 0.04 14.0 1.1 0.09 12.8 0.1 2.2 3 0 0 3 3 1 0 NUMB domain Dna2 PF08696.6 ESS61992.1 - 0.073 12.3 4.8 5.9 6.1 0.2 3.1 1 1 1 3 3 3 0 DNA replication factor Dna2 Reo_sigmaC PF04582.7 ESS61992.1 - 0.097 11.8 4.3 2.4 7.2 0.3 2.5 1 1 2 3 3 3 0 Reovirus sigma C capsid protein TBPIP PF07106.8 ESS61992.1 - 0.19 11.2 16.1 3.6 7.1 0.5 3.3 1 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3347 PF11827.3 ESS61992.1 - 0.22 11.5 9.1 1.3 8.9 1.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3347) Tropomyosin PF00261.15 ESS61992.1 - 0.27 10.2 26.8 2.4 7.1 16.8 2.7 1 1 0 1 1 1 0 Tropomyosin Bacillus_HBL PF05791.6 ESS61992.1 - 0.31 10.3 12.8 0.74 9.1 0.2 3.1 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.7 ESS61992.1 - 0.33 10.7 14.0 3.3 7.5 1.2 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.4 ESS61992.1 - 0.34 11.0 12.5 1.7 8.7 0.2 3.4 1 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.1 ESS61992.1 - 0.36 10.1 20.3 0.03 13.6 6.4 3.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) GCIP PF13324.1 ESS61992.1 - 0.47 9.6 5.2 0.82 8.8 2.0 2.0 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting TACC PF05010.9 ESS61992.1 - 0.49 10.1 24.4 0.81 9.4 7.2 2.1 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) Fib_alpha PF08702.5 ESS61992.1 - 0.54 10.3 17.3 3.3 7.8 2.7 4.0 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family THP2 PF09432.5 ESS61992.1 - 0.57 10.0 5.4 6.9 6.5 0.1 3.4 2 2 0 2 2 2 0 Tho complex subunit THP2 TPR_MLP1_2 PF07926.7 ESS61992.1 - 0.78 9.4 24.4 40 3.9 7.6 3.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Retrotrans_gag PF03732.12 ESS61992.1 - 1 9.5 5.1 2 8.5 0.1 3.0 2 2 0 2 2 2 0 Retrotransposon gag protein Hemagglutinin PF00509.13 ESS61992.1 - 1 7.4 3.5 10 4.1 0.1 2.3 1 1 1 2 2 2 0 Haemagglutinin AcylCoA_dehyd_C PF12186.3 ESS61992.1 - 1 9.2 6.9 2 8.3 0.0 3.6 2 2 1 3 3 3 0 Acyl-CoA dehydrogenase C terminal Mnd1 PF03962.10 ESS61992.1 - 1.4 8.5 19.7 0.033 13.8 3.0 3.0 1 1 3 4 4 4 0 Mnd1 family Sec2p PF06428.6 ESS61992.1 - 1.4 8.8 14.9 0.081 12.7 3.9 3.3 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p TMPIT PF07851.8 ESS61992.1 - 1.4 7.8 15.9 3.6 6.5 1.1 3.1 1 1 2 3 3 3 0 TMPIT-like protein DUF2317 PF10079.4 ESS61992.1 - 1.6 7.2 19.4 1.6 7.2 2.4 2.7 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2317) Cytochrom_B562 PF07361.6 ESS61992.1 - 3.2 8.2 9.7 13 6.2 1.0 3.4 1 1 0 2 2 2 0 Cytochrome b562 DUF2580 PF10824.3 ESS61992.1 - 4 7.8 9.5 1.1 9.6 1.5 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF2580) Lectin_N PF03954.9 ESS61992.1 - 4 6.8 8.5 0.83 9.0 0.2 3.1 1 1 0 2 2 2 0 Hepatic lectin, N-terminal domain V_ATPase_I PF01496.14 ESS61992.1 - 5.4 4.7 19.0 8.4 4.1 7.1 2.2 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Streptin-Immun PF11083.3 ESS61992.1 - 8.1 6.5 8.1 5.8 6.9 0.2 3.6 1 1 0 3 3 3 0 Lantibiotic streptin immunity protein Peptidase_C6 PF00851.13 ESS61992.1 - 8.1 4.9 8.6 4.1 5.9 1.6 2.1 2 0 0 2 2 2 0 Helper component proteinase Ank_2 PF12796.2 ESS61994.1 - 1.6e-16 60.3 9.6 3.6e-10 40.0 0.4 4.6 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESS61994.1 - 1.1e-09 37.5 11.8 0.026 14.3 0.1 7.0 6 1 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.1 ESS61994.1 - 2.9e-09 36.2 9.4 0.35 11.2 0.0 7.5 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.1 ESS61994.1 - 4.6e-09 36.2 8.1 9.1e-06 25.7 0.3 6.0 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS61994.1 - 1.1e-08 35.3 3.3 0.076 13.5 0.0 6.5 5 2 3 8 8 8 2 Ankyrin repeats (many copies) Orbi_VP6 PF01516.11 ESS61994.1 - 0.062 12.3 3.7 0.097 11.7 2.6 1.2 1 0 0 1 1 1 0 Orbivirus helicase VP6 DUF2956 PF11169.3 ESS61994.1 - 0.72 9.8 4.7 16 5.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Methyltransf_11 PF08241.7 ESS61995.1 - 6.5e-09 36.1 0.0 2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS61995.1 - 1.6e-08 34.4 0.1 5.9e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS61995.1 - 3.7e-07 30.5 0.0 8.1e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS61995.1 - 0.0001 21.9 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESS61995.1 - 0.045 13.3 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Ubie_methyltran PF01209.13 ESS61995.1 - 0.083 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ldh_1_C PF02866.13 ESS61996.1 - 1.2e-09 38.1 0.0 1.3e-09 38.0 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Bac_chlorC PF02043.12 ESS61998.1 - 0.015 15.0 0.0 0.041 13.6 0.0 1.7 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein Kinesin PF00225.18 ESS61999.1 - 9.3e-98 327.0 0.3 2.5e-97 325.6 0.0 1.9 2 1 0 2 2 2 1 Kinesin motor domain IncA PF04156.9 ESS61999.1 - 0.67 9.5 39.0 1.1 8.8 8.4 2.6 2 0 0 2 2 2 0 IncA protein PolyA_pol PF01743.15 ESS61999.1 - 6 7.0 9.6 0.2 11.8 0.4 3.0 2 1 1 3 3 3 0 Poly A polymerase head domain Mucin PF01456.12 ESS62002.1 - 0.00023 20.9 3.9 0.00051 19.8 2.7 1.6 1 0 0 1 1 1 1 Mucin-like glycoprotein Shisa PF13908.1 ESS62002.1 - 0.037 14.2 2.1 0.097 12.8 1.4 1.7 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4212 PF13937.1 ESS62003.1 - 0.19 11.7 5.3 0.17 11.8 2.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4212) Peptidase_M8 PF01457.11 ESS62006.1 - 4.7e-30 104.4 0.0 5.1e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Leishmanolysin RPAP2_Rtr1 PF04181.8 ESS62007.1 - 0.12 12.4 0.7 0.15 12.1 0.5 1.2 1 0 0 1 1 1 0 Rtr1/RPAP2 family BNR_3 PF13859.1 ESS62008.1 - 1.8e-131 437.8 6.5 1.8e-131 437.8 4.5 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62008.1 - 4e-17 62.8 0.7 1.4e-16 61.1 0.2 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62008.1 - 7.2e-10 38.5 9.8 2.3e-09 36.9 6.8 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS62009.1 - 2.2e-15 57.1 18.1 2.2e-15 57.1 12.5 4.1 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) Mucin PF01456.12 ESS62011.1 - 9.4e-40 135.6 19.3 1.3e-39 135.2 13.4 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.6 ESS62011.1 - 0.00058 17.9 15.7 0.00076 17.6 10.9 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 DUF3439 PF11921.3 ESS62011.1 - 0.053 13.2 13.5 0.084 12.6 9.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.7 ESS62011.1 - 0.13 10.0 11.5 0.15 9.7 8.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4658 PF15555.1 ESS62011.1 - 0.8 9.5 3.4 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) TMEM154 PF15102.1 ESS62011.1 - 2.1 8.0 6.8 3.6 7.2 4.7 1.4 1 0 0 1 1 1 0 TMEM154 protein family Med3 PF11593.3 ESS62011.1 - 3.6 6.7 11.9 4.4 6.4 8.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Daxx PF03344.10 ESS62012.1 - 0.049 12.1 18.4 0.059 11.8 12.7 1.1 1 0 0 1 1 1 0 Daxx Family Menin PF05053.8 ESS62012.1 - 0.25 9.4 10.8 0.39 8.8 7.5 1.3 1 0 0 1 1 1 0 Menin Utp14 PF04615.8 ESS62012.1 - 1.3 7.1 18.9 1.5 6.8 13.1 1.0 1 0 0 1 1 1 0 Utp14 protein BNR_3 PF13859.1 ESS62013.1 - 4.5e-88 295.2 4.3 4.5e-88 295.2 3.0 2.4 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62013.1 - 1.2e-16 61.2 1.2 3e-16 60.0 0.4 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62013.1 - 5.5e-10 38.9 9.6 5.5e-10 38.9 6.6 2.4 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62013.1 - 6.7e-05 22.3 0.9 0.00036 19.9 0.1 2.3 2 1 0 2 2 2 1 BNR repeat-like domain DUF4131 PF13567.1 ESS62019.1 - 0.22 10.9 2.3 0.25 10.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF1378 PF07125.6 ESS62020.1 - 0.63 10.0 2.8 0.97 9.4 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1378) Mucin PF01456.12 ESS62022.1 - 5.7e-33 113.6 40.6 5.7e-33 113.6 28.1 3.4 2 2 0 2 2 2 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS62022.1 - 0.011 15.6 0.1 0.011 15.6 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4658) TMEM154 PF15102.1 ESS62022.1 - 6.5 6.4 7.9 22 4.7 4.2 2.2 2 0 0 2 2 2 0 TMEM154 protein family Daxx PF03344.10 ESS62023.1 - 0.16 10.4 15.5 0.19 10.1 10.7 1.1 1 0 0 1 1 1 0 Daxx Family Menin PF05053.8 ESS62023.1 - 2.8 5.9 10.3 3.9 5.5 7.1 1.2 1 0 0 1 1 1 0 Menin DUF2826 PF11442.3 ESS62024.1 - 4.2e-60 202.0 8.2 6.8e-60 201.3 5.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) Glyco_transf_10 PF00852.14 ESS62025.1 - 9.1e-26 90.2 0.3 1.9e-22 79.3 0.1 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 10 (fucosyltransferase) DUF4131 PF13567.1 ESS62025.1 - 1.2 8.5 5.4 12 5.2 2.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) CorA PF01544.13 ESS62026.1 - 9.2e-16 57.7 0.1 1.8e-14 53.4 0.1 2.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CorA PF01544.13 ESS62027.1 - 2.2e-20 72.8 0.1 6.7e-20 71.3 0.1 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein AAA PF00004.24 ESS62028.1 - 4.3e-36 124.0 0.0 6.9e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS62028.1 - 0.00011 21.2 0.0 0.00029 19.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESS62028.1 - 0.00015 21.8 0.0 0.0086 16.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESS62028.1 - 0.00064 18.5 0.0 0.00097 17.9 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 ESS62028.1 - 0.001 18.7 0.1 0.0063 16.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS62028.1 - 0.0049 16.8 0.2 0.011 15.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESS62028.1 - 0.0075 17.0 0.0 0.013 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS62028.1 - 0.0097 15.6 1.6 0.026 14.2 0.1 2.6 2 1 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 ESS62028.1 - 0.022 14.1 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESS62028.1 - 0.031 13.4 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESS62028.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Vps4_C PF09336.5 ESS62028.1 - 0.09 12.6 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Sigma54_activat PF00158.21 ESS62028.1 - 0.098 12.1 0.0 0.59 9.5 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain CTDII PF01556.13 ESS62031.1 - 3.6e-22 78.0 0.1 2.1e-21 75.5 0.0 2.1 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.26 ESS62031.1 - 1.5e-18 66.3 0.5 2.5e-18 65.5 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESS62031.1 - 5e-17 61.7 11.0 8.9e-17 60.9 7.6 1.4 1 0 0 1 1 1 1 DnaJ central domain DUF2823 PF11034.3 ESS62031.1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2823) zf-RING_3 PF14369.1 ESS62031.1 - 0.54 10.3 5.0 10 6.1 1.9 2.9 2 1 1 3 3 3 0 zinc-finger DUF2318 PF10080.4 ESS62031.1 - 1.8 8.3 6.4 3.6 7.4 0.2 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) PADR1 PF08063.7 ESS62031.1 - 3.5 7.0 10.3 1.3 8.4 0.9 3.0 2 1 1 3 3 3 0 PADR1 (NUC008) domain HypA PF01155.14 ESS62031.1 - 6.3 6.5 8.5 0.58 9.8 0.8 2.2 1 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Kelch_6 PF13964.1 ESS62032.1 - 7e-09 35.4 0.6 0.011 15.8 0.0 5.4 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.20 ESS62032.1 - 3e-07 29.8 0.4 0.077 12.5 0.0 5.0 4 2 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESS62032.1 - 8.9e-07 28.4 0.1 0.31 10.8 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 ESS62032.1 - 3.1e-06 26.9 0.6 0.013 15.4 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 ESS62032.1 - 4.5e-06 26.3 5.2 0.4 10.4 0.2 5.4 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS62032.1 - 0.00013 22.0 12.5 7.4 6.8 1.4 7.6 6 2 0 6 6 6 1 Galactose oxidase, central domain RAG2 PF03089.9 ESS62032.1 - 0.052 12.2 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Recombination activating protein 2 Nucleoplasmin PF03066.10 ESS62034.1 - 0.89 9.0 8.5 0.27 10.7 3.1 2.1 2 0 0 2 2 2 0 Nucleoplasmin Nop14 PF04147.7 ESS62034.1 - 2.3 6.0 7.8 2.7 5.8 5.4 1.1 1 0 0 1 1 1 0 Nop14-like family Nop14 PF04147.7 ESS62036.1 - 0.029 12.2 25.6 0.033 12.1 17.7 1.0 1 0 0 1 1 1 0 Nop14-like family DUF3043 PF11241.3 ESS62036.1 - 0.24 10.9 0.0 0.24 10.9 0.0 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) SOBP PF15279.1 ESS62036.1 - 2.3 8.5 6.9 2.9 8.1 4.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein CCAP PF11105.3 ESS62037.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a BNR_3 PF13859.1 ESS62039.1 - 1.3e-14 54.0 0.0 1.6e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Mitofilin PF09731.4 ESS62040.1 - 0.33 9.5 10.9 0.39 9.3 7.6 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Neur_chan_memb PF02932.11 ESS62040.1 - 3.9 7.2 6.2 59 3.4 4.3 2.1 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Exo_endo_phos_2 PF14529.1 ESS62041.1 - 1.8e-12 46.8 0.1 2.9e-12 46.2 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS62041.1 - 7.9e-06 25.9 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BNR_3 PF13859.1 ESS62042.1 - 1.9e-125 418.0 4.8 1.9e-125 418.0 3.4 1.8 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62042.1 - 3.8e-18 66.1 0.7 1.1e-17 64.7 0.5 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62042.1 - 9.5e-08 31.7 11.3 2.6e-07 30.3 7.8 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62042.1 - 0.00021 20.7 0.3 0.0006 19.1 0.2 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Vac7 PF12751.2 ESS62042.1 - 0.13 11.1 0.4 0.19 10.5 0.3 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 UEV PF05743.8 ESS62043.1 - 8e-14 51.3 0.0 5.1e-13 48.7 0.0 1.9 2 0 0 2 2 2 1 UEV domain zf-C3HC4_3 PF13920.1 ESS62043.1 - 1.9e-10 40.2 12.8 5.4e-10 38.7 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RWD PF05773.17 ESS62043.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 RWD domain ASRT PF07100.6 ESS62045.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 1 1 2 2 2 0 Anabaena sensory rhodopsin transducer Mucin PF01456.12 ESS62046.1 - 0.56 9.9 3.9 0.7 9.6 2.7 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS62048.1 - 1.2e-131 438.4 5.6 1.2e-131 438.4 3.9 2.4 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS62048.1 - 1.2e-10 41.0 11.1 2.9e-10 39.8 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62050.1 - 3.4e-14 52.6 0.1 7.9e-09 35.0 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.1 ESS62052.1 - 1.2e-133 445.0 5.4 1.2e-133 445.0 3.7 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62052.1 - 7.7e-17 61.9 1.9 1.9e-16 60.7 0.2 2.4 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62052.1 - 2.4e-10 40.1 10.1 2.4e-10 40.1 7.0 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62052.1 - 0.00073 18.9 0.2 0.0012 18.1 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Glyco_hydro_32N PF00251.15 ESS62052.1 - 0.17 11.1 1.0 19 4.5 0.1 3.1 3 1 1 4 4 4 0 Glycosyl hydrolases family 32 N-terminal domain Tr-sialidase_C PF11052.3 ESS62053.1 - 6e-06 26.0 0.3 6e-06 26.0 0.2 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Na_Ca_ex PF01699.19 ESS62053.1 - 0.49 10.0 3.5 0.6 9.6 2.5 1.1 1 0 0 1 1 1 0 Sodium/calcium exchanger protein Tetraspannin PF00335.15 ESS62053.1 - 3.8 6.7 11.5 4.4 6.5 8.0 1.1 1 0 0 1 1 1 0 Tetraspanin family CDC27 PF09507.5 ESS62054.1 - 0.38 9.9 19.7 0.49 9.5 13.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pilt PF15453.1 ESS62054.1 - 0.38 10.3 13.4 0.51 9.9 9.3 1.1 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions Nop14 PF04147.7 ESS62054.1 - 0.58 8.0 20.3 0.7 7.7 14.1 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESS62054.1 - 0.7 7.8 17.9 0.93 7.4 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 ESS62054.1 - 1.2 8.4 23.0 1.7 7.9 15.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CENP-T PF15511.1 ESS62054.1 - 1.7 7.7 16.3 2.2 7.4 11.3 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Daxx PF03344.10 ESS62054.1 - 1.7 7.0 20.5 2.3 6.5 14.2 1.1 1 0 0 1 1 1 0 Daxx Family MIP-T3 PF10243.4 ESS62054.1 - 1.8 6.9 27.1 2.3 6.5 18.8 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RR_TM4-6 PF06459.7 ESS62054.1 - 2.5 7.9 15.8 3.6 7.3 11.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Myc_N PF01056.13 ESS62054.1 - 5 6.1 13.2 7 5.7 9.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PPP4R2 PF09184.6 ESS62054.1 - 8.4 5.8 21.1 11 5.4 14.6 1.1 1 0 0 1 1 1 0 PPP4R2 BNR_3 PF13859.1 ESS62056.1 - 5.2e-62 209.6 0.1 8.3e-62 209.0 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62056.1 - 0.00034 19.9 0.0 0.0027 17.0 0.0 2.2 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS62056.1 - 0.017 14.8 1.1 0.22 11.5 0.1 3.8 4 0 0 4 4 4 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS62059.1 - 1.8e-57 194.7 0.5 3.9e-57 193.6 0.0 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62059.1 - 2e-15 57.4 0.1 5.6e-15 55.9 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62059.1 - 3.2e-10 39.6 10.4 6.2e-10 38.7 7.2 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62060.1 - 2.9e-18 65.9 0.9 5.9e-18 64.9 0.2 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Mucin PF01456.12 ESS62060.1 - 0.0022 17.7 7.7 0.0052 16.5 1.1 2.2 2 0 0 2 2 2 2 Mucin-like glycoprotein Peptidase_M8 PF01457.11 ESS62062.1 - 4.8e-29 101.1 0.1 6e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M8 PF01457.11 ESS62063.1 - 1.3e-30 106.2 0.0 1.7e-30 105.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Mucin PF01456.12 ESS62063.1 - 0.061 13.0 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2477 PF10631.4 ESS62068.1 - 0.014 15.5 0.8 0.029 14.5 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2477) Tyr-DNA_phospho PF06087.7 ESS62069.1 - 1.3e-75 254.6 0.0 1.6e-75 254.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 ESS62069.1 - 0.05 13.3 0.0 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 PLD-like domain FBPase PF00316.15 ESS62073.1 - 1.3e-64 218.1 0.0 1.6e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 ESS62073.1 - 0.0025 17.1 0.0 0.014 14.7 0.0 2.1 2 1 0 2 2 2 1 Inositol monophosphatase family YqgF PF14639.1 ESS62074.1 - 3.1e-12 46.2 0.0 1.4e-11 44.1 0.0 2.1 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 SH2_2 PF14633.1 ESS62074.1 - 1e-08 34.5 0.0 1.9e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 SH2 domain HHH_7 PF14635.1 ESS62074.1 - 0.043 13.9 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Trypsin_2 PF13365.1 ESS62076.1 - 0.00023 21.1 0.0 0.00031 20.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 ESS62076.1 - 0.073 12.6 0.0 0.11 12.0 0.0 1.5 1 1 0 1 1 1 0 Trypsin LSM PF01423.17 ESS62077.1 - 3.5e-14 52.0 0.6 5.1e-14 51.5 0.4 1.2 1 0 0 1 1 1 1 LSM domain Ras PF00071.17 ESS62078.1 - 1.3e-51 174.2 0.7 1.6e-51 173.9 0.5 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS62078.1 - 1.2e-23 83.8 0.1 1.9e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS62078.1 - 1.1e-15 57.3 0.2 1.3e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESS62078.1 - 1.7e-06 27.6 0.1 4.4e-06 26.2 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESS62078.1 - 7.3e-06 25.2 0.1 9.7e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESS62078.1 - 6.9e-05 22.7 0.1 0.00015 21.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESS62078.1 - 0.00042 19.5 0.0 0.00068 18.8 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 ESS62078.1 - 0.027 13.9 0.1 0.52 9.7 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arch_ATPase PF01637.13 ESS62078.1 - 0.069 12.8 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_14 PF13173.1 ESS62078.1 - 0.11 12.4 0.1 0.27 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain BNR_3 PF13859.1 ESS62080.1 - 1.7e-131 437.9 1.8 1.7e-131 437.9 1.2 2.3 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62080.1 - 4.7e-17 62.6 1.0 1.4e-16 61.1 0.7 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62080.1 - 6.3e-09 35.5 8.7 6.3e-09 35.5 6.0 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62086.1 - 4.2e-125 416.9 5.1 4.2e-125 416.9 3.5 2.0 3 0 0 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62086.1 - 3.5e-19 69.5 0.2 1.7e-18 67.3 0.2 2.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62086.1 - 8.7e-08 31.9 11.6 8.7e-08 31.9 8.0 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mo-co_dimer PF03404.11 ESS62086.1 - 0.027 14.1 0.2 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Mo-co oxidoreductase dimerisation domain Laminin_G_2 PF02210.19 ESS62086.1 - 0.028 14.4 0.1 0.075 13.0 0.1 1.7 1 0 0 1 1 1 0 Laminin G domain SSB PF00436.20 ESS62090.1 - 0.079 12.8 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Single-strand binding protein family DUF4607 PF15380.1 ESS62090.1 - 0.092 12.1 5.9 0.24 10.7 4.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4607) Mucin PF01456.12 ESS62095.1 - 1.2e-38 132.0 47.6 1.6e-37 128.4 33.0 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein Pneumo_att_G PF05539.6 ESS62095.1 - 0.66 9.2 26.4 0.83 8.9 18.3 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G FAM176 PF14851.1 ESS62095.1 - 5.6 6.6 5.5 1.8 8.2 1.0 2.1 1 1 2 3 3 3 0 FAM176 family DUF3676 PF12429.3 ESS62097.1 - 3.4e-100 334.3 47.2 5.3e-100 333.7 32.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS62097.1 - 1.8e-82 276.9 0.3 1.8e-82 276.9 0.2 3.1 3 1 0 4 4 4 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62097.1 - 2.9e-11 43.8 0.7 2.9e-11 43.8 0.5 2.9 3 1 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62097.1 - 7.4e-11 41.7 7.2 1.5e-10 40.6 5.0 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4446 PF14584.1 ESS62098.1 - 0.11 12.3 0.2 0.19 11.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Laminin_G_3 PF13385.1 ESS62099.1 - 8.3e-09 35.8 0.1 1.3e-08 35.1 0.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS62100.1 - 2.8e-59 200.8 0.0 3.4e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DGF-1_5 PF11038.3 ESS62102.1 - 1.3e-151 503.5 18.2 1.3e-151 503.5 12.6 1.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS62102.1 - 2.8e-16 59.1 5.0 6.8e-16 57.9 3.5 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF1129 PF06570.6 ESS62102.1 - 0.07 12.4 2.0 0.08 12.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) HEV_ORF1 PF02444.11 ESS62102.1 - 1.2 9.3 8.3 0.64 10.2 1.2 3.0 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) BNR_3 PF13859.1 ESS62103.1 - 1.1e-125 418.8 5.2 1.1e-125 418.8 3.6 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62103.1 - 2.8e-18 66.6 1.0 1.1e-17 64.7 0.5 2.3 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62103.1 - 2.7e-10 39.9 11.1 2.7e-10 39.9 7.7 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Lysozyme_like PF13702.1 ESS62103.1 - 0.036 13.5 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Lysozyme-like DUF2786 PF10979.3 ESS62105.1 - 0.1 12.3 0.3 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) DUF2826 PF11442.3 ESS62107.1 - 2.9e-60 202.5 7.7 5.9e-60 201.5 5.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) BNR_3 PF13859.1 ESS62109.1 - 3.6e-129 430.2 3.5 8e-129 429.1 2.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62109.1 - 2.6e-15 57.0 0.1 8.5e-15 55.3 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1272 PF06906.6 ESS62109.1 - 0.023 14.5 1.1 0.054 13.3 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) DGF-1_5 PF11038.3 ESS62111.1 - 4.4e-93 311.5 4.2 6.5e-93 310.9 2.9 1.2 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS62111.1 - 2e-32 111.3 18.2 4.7e-32 110.1 12.6 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Beta_helix PF13229.1 ESS62112.1 - 0.034 13.8 1.2 0.24 11.1 0.8 2.1 1 1 0 1 1 1 0 Right handed beta helix region hEGF PF12661.2 ESS62113.1 - 0.099 12.7 2.0 0.25 11.5 1.4 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.8 ESS62113.1 - 3.2 8.0 12.0 12 6.1 8.3 2.0 1 1 0 1 1 1 0 EGF-like domain ASRT PF07100.6 ESS62114.1 - 0.032 13.9 0.0 0.07 12.8 0.0 1.6 2 0 0 2 2 2 0 Anabaena sensory rhodopsin transducer Peptidase_M8 PF01457.11 ESS62114.1 - 0.037 12.3 0.0 0.037 12.3 0.0 1.1 1 0 0 1 1 1 0 Leishmanolysin Corona_S2 PF01601.11 ESS62114.1 - 0.2 9.7 3.3 0.26 9.3 2.3 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Mucin PF01456.12 ESS62115.1 - 1.1e-29 103.1 51.5 4.2e-28 97.9 35.7 2.8 1 1 0 1 1 1 1 Mucin-like glycoprotein Nop14 PF04147.7 ESS62115.1 - 0.19 9.5 2.8 0.26 9.1 1.9 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3439 PF11921.3 ESS62115.1 - 0.42 10.3 20.5 0.043 13.5 10.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF3484 PF11983.3 ESS62115.1 - 7.5 7.4 11.2 0.28 12.0 2.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3484) DUF3302 PF11742.3 ESS62116.1 - 0.052 13.4 1.1 2.5 8.0 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3302) DGF-1_5 PF11038.3 ESS62120.1 - 8.4e-165 546.7 18.9 8.4e-165 546.7 13.1 2.2 2 1 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS62120.1 - 2.4e-40 136.7 15.6 7.3e-40 135.2 10.8 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS62120.1 - 1.2e-37 127.6 1.3 2.6e-37 126.5 0.9 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus RHSP PF07999.6 ESS62125.1 - 9e-49 166.2 0.0 1e-48 166.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS62126.1 - 9.5e-15 54.1 0.0 1.4e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS62128.1 - 5e-122 407.6 0.2 7.5e-122 407.0 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS62128.1 - 0.011 15.8 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF3502 PF12010.3 ESS62128.1 - 0.054 13.4 0.2 0.71 9.8 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3502) Laminin_G_3 PF13385.1 ESS62130.1 - 1.5e-13 51.2 0.6 2.1e-13 50.7 0.4 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 ESS62130.1 - 0.038 14.0 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain EGF_alliinase PF04863.8 ESS62130.1 - 0.11 12.4 0.0 2.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Alliinase EGF-like domain Tr-sialidase_C PF11052.3 ESS62130.1 - 0.56 10.1 6.7 1 9.2 4.7 1.4 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS62131.1 - 2.2e-128 428.5 0.1 3.4e-128 427.9 0.1 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS62132.1 - 4.8e-63 213.0 0.1 8.7e-63 212.2 0.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62132.1 - 3.7e-12 46.7 0.0 9.8e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62132.1 - 1.7e-06 27.8 9.1 1.7e-06 27.8 6.3 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS62132.1 - 0.0022 17.5 0.2 2.3 8.4 0.1 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat RHSP PF07999.6 ESS62135.1 - 1.2e-45 155.9 0.0 1.3e-45 155.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF1675 PF07897.6 ESS62136.1 - 2.3 8.0 10.8 2.8 7.7 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) zf-C2H2_4 PF13894.1 ESS62137.1 - 0.02 15.1 3.0 0.073 13.4 0.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS62137.1 - 0.052 13.9 3.3 0.095 13.0 0.2 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type RVT_1 PF00078.22 ESS62138.1 - 0.0059 15.9 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2616 PF11077.3 ESS62139.1 - 0.12 11.8 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) BNR_3 PF13859.1 ESS62144.1 - 1.1e-122 409.0 3.7 1.1e-122 409.0 2.6 1.8 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62144.1 - 5e-17 62.5 0.9 1.2e-16 61.3 0.6 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62144.1 - 1.5e-07 31.1 5.8 4.2e-07 29.7 4.0 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS62144.1 - 0.072 12.0 0.1 0.14 11.0 0.0 1.5 1 0 0 1 1 1 0 Sialidase, N-terminal domain SieB PF14163.1 ESS62146.1 - 0.031 13.8 0.1 0.031 13.8 0.1 1.7 2 0 0 2 2 2 0 Superinfection exclusion protein B DUF996 PF06195.8 ESS62146.1 - 0.073 13.0 0.5 0.34 10.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Ctr PF04145.10 ESS62146.1 - 0.17 11.9 6.6 1 9.3 4.5 2.4 1 1 0 1 1 1 0 Ctr copper transporter family RskA PF10099.4 ESS62146.1 - 0.24 11.1 3.6 1.1 9.0 0.7 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF4094 PF13334.1 ESS62146.1 - 0.25 11.7 2.0 0.46 10.8 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) SpoIIIAH PF12685.2 ESS62146.1 - 0.56 9.6 3.2 0.78 9.1 0.2 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein PepSY_TM PF03929.11 ESS62146.1 - 1.3 9.5 3.9 6.8 7.3 0.1 2.6 2 0 0 2 2 2 0 PepSY-associated TM helix BNR_3 PF13859.1 ESS62147.1 - 3.4e-92 308.8 2.2 3.4e-92 308.8 1.5 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62147.1 - 4e-20 72.6 0.5 1.2e-19 71.1 0.1 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62147.1 - 1.2e-07 31.5 14.0 2.4e-07 30.4 9.7 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Sialidase PF02973.11 ESS62147.1 - 0.057 12.3 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Sialidase, N-terminal domain Mucin PF01456.12 ESS62150.1 - 8e-37 126.1 50.6 1.1e-23 83.6 22.2 2.0 1 1 1 2 2 2 2 Mucin-like glycoprotein Peptidase_M8 PF01457.11 ESS62151.1 - 0.042 12.1 0.0 0.048 11.9 0.0 1.0 1 0 0 1 1 1 0 Leishmanolysin DNA_pol_viral_C PF00336.13 ESS62152.1 - 0.0019 17.4 0.0 0.0045 16.2 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase (viral) C-terminal domain TniQ PF06527.6 ESS62153.1 - 0.095 12.9 1.1 0.21 11.7 0.2 2.1 2 1 0 2 2 2 0 TniQ IncA PF04156.9 ESS62154.1 - 0.011 15.3 0.9 0.017 14.7 0.7 1.2 1 0 0 1 1 1 0 IncA protein MAD PF05557.8 ESS62154.1 - 0.039 12.0 3.1 0.052 11.6 2.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF4407 PF14362.1 ESS62154.1 - 0.04 12.8 5.1 0.059 12.3 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IFT57 PF10498.4 ESS62154.1 - 0.064 11.9 2.0 0.096 11.4 1.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF4201 PF13870.1 ESS62154.1 - 0.16 11.4 1.5 0.25 10.7 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) TAP42 PF04177.7 ESS62155.1 - 1.4e-31 109.7 5.8 1.8e-31 109.3 4.1 1.1 1 0 0 1 1 1 1 TAP42-like family ATP_bind_1 PF03029.12 ESS62157.1 - 8.1e-59 199.0 0.0 9.6e-59 198.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 ESS62157.1 - 9.4e-07 29.6 0.1 3.1e-06 28.0 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESS62157.1 - 6.3e-05 23.0 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 ESS62157.1 - 0.00012 21.7 0.1 0.00023 20.8 0.1 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 ESS62157.1 - 0.00013 22.1 0.1 0.00034 20.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ESS62157.1 - 0.0013 18.2 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain MobB PF03205.9 ESS62157.1 - 0.0014 18.3 0.1 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 ESS62157.1 - 0.0016 18.0 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.18 ESS62157.1 - 0.0022 17.4 0.0 0.0082 15.5 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.18 ESS62157.1 - 0.0036 17.2 0.0 0.012 15.5 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ESS62157.1 - 0.0039 16.6 0.0 0.16 11.4 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 ESS62157.1 - 0.004 17.4 0.0 0.0075 16.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.1 ESS62157.1 - 0.0045 17.3 0.0 0.011 15.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.17 ESS62157.1 - 0.0074 15.7 0.1 0.022 14.1 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain KAP_NTPase PF07693.9 ESS62157.1 - 0.0077 15.2 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain RNA_helicase PF00910.17 ESS62157.1 - 0.0097 16.0 0.0 0.15 12.2 0.0 2.4 2 1 0 2 2 2 1 RNA helicase AAA_25 PF13481.1 ESS62157.1 - 0.0098 15.3 0.1 0.027 13.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESS62157.1 - 0.01 15.7 0.0 0.023 14.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 ESS62157.1 - 0.011 14.9 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_33 PF13671.1 ESS62157.1 - 0.012 15.5 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESS62157.1 - 0.021 14.3 0.1 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 ESS62157.1 - 0.03 13.9 0.0 0.098 12.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 ESS62157.1 - 0.049 13.8 0.0 0.091 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 ESS62157.1 - 0.057 12.1 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 ArgK protein AAA_5 PF07728.9 ESS62157.1 - 0.063 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 ESS62157.1 - 0.094 12.6 0.3 0.18 11.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESS62157.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.12 ESS62157.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase Viral_helicase1 PF01443.13 ESS62157.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase T2SE PF00437.15 ESS62157.1 - 0.17 10.7 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Surp PF01805.15 ESS62158.1 - 1.8e-12 46.6 5.3 4.1e-10 39.1 0.1 2.3 2 0 0 2 2 2 2 Surp module DNA_pol_E_B PF04042.11 ESS62159.1 - 9.3e-32 109.9 0.2 5.3e-19 68.2 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase alpha/epsilon subunit B Cluap1 PF10234.4 ESS62161.1 - 2.2e-15 56.6 2.4 3.1e-15 56.1 1.7 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 RNase_T PF00929.19 ESS62162.1 - 3e-08 34.1 0.0 5.4e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DUF1295 PF06966.7 ESS62164.1 - 2.9e-08 33.3 0.6 5.6e-08 32.3 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 ESS62164.1 - 4.7e-06 26.6 0.4 1.5e-05 25.0 0.1 2.0 1 1 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.11 ESS62164.1 - 3.4e-05 23.6 2.9 3.8e-05 23.4 1.0 1.9 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.9 ESS62164.1 - 0.00064 19.8 0.1 0.0037 17.4 0.0 2.3 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ERG4_ERG24 PF01222.12 ESS62164.1 - 0.0036 15.9 0.4 0.0036 15.9 0.3 1.6 2 0 0 2 2 2 1 Ergosterol biosynthesis ERG4/ERG24 family RF-1 PF00472.15 ESS62165.1 - 2.7e-31 107.7 0.1 8.6e-31 106.0 0.0 1.9 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.13 ESS62165.1 - 6.3e-11 41.9 0.4 1.6e-10 40.6 0.3 1.8 1 1 0 1 1 1 1 PCRF domain DUF1126 PF06565.7 ESS62166.1 - 1.7e-33 113.7 0.8 1.1e-09 37.5 0.0 3.6 3 0 0 3 3 3 3 Repeat of unknown function (DUF1126) DUF2909 PF11137.3 ESS62168.1 - 0.13 11.9 0.3 1.6 8.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) Daxx PF03344.10 ESS62169.1 - 0.85 8.0 14.5 0.96 7.8 10.1 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 ESS62169.1 - 6.2 4.6 12.8 7.9 4.2 8.9 1.1 1 0 0 1 1 1 0 Nop14-like family BNR_3 PF13859.1 ESS62170.1 - 4.4e-134 446.4 6.0 4.4e-134 446.4 4.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain TMEM52 PF14979.1 ESS62172.1 - 3.7 7.4 7.3 4.8 7.0 5.1 1.2 1 0 0 1 1 1 0 Transmembrane 52 ABC2_membrane_3 PF12698.2 ESS62172.1 - 9.5 5.1 16.8 11 4.9 11.7 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Mucin PF01456.12 ESS62173.1 - 0.00016 21.4 3.4 0.00016 21.4 2.4 4.1 3 1 0 3 3 3 1 Mucin-like glycoprotein RHSP PF07999.6 ESS62176.1 - 5.2e-35 120.8 0.0 6.5e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS62177.1 - 1.7e-09 36.8 0.2 2.3e-09 36.3 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein KMP11 PF03037.11 ESS62179.1 - 0.09 13.3 1.6 0.2 12.2 1.1 1.5 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 BNR_3 PF13859.1 ESS62180.1 - 3.7e-131 436.8 1.1 3.7e-131 436.8 0.8 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62180.1 - 2.9e-16 60.0 1.6 2.9e-16 60.0 1.1 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62180.1 - 1.5e-07 31.1 11.9 3.8e-07 29.8 8.3 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62180.1 - 0.0099 15.1 0.2 0.027 13.7 0.1 1.7 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS62182.1 - 4.5e-14 51.8 0.3 8.1e-14 51.0 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS62183.1 - 0.0087 14.6 1.0 0.057 12.0 0.0 2.0 2 0 0 2 2 2 2 Retrotransposon hot spot protein Ribosomal_L37e PF01907.14 ESS62184.1 - 0.14 11.9 3.5 0.095 12.5 0.7 2.0 2 0 0 2 2 2 0 Ribosomal protein L37e RHSP PF07999.6 ESS62185.1 - 8.6e-24 83.9 0.6 1.3e-23 83.3 0.4 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF348 PF03990.9 ESS62185.1 - 0.041 13.4 0.2 0.23 11.0 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF348) BNR_3 PF13859.1 ESS62186.1 - 4.2e-67 226.4 0.4 7.9e-67 225.5 0.3 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62186.1 - 5.1e-14 52.8 0.5 2.3e-13 50.6 0.0 2.3 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62186.1 - 3.3e-06 26.8 8.8 3.3e-06 26.8 6.1 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS62186.1 - 2.2e-05 23.6 3.5 0.18 11.7 0.4 3.4 2 0 0 2 2 2 2 BNR/Asp-box repeat Laminin_G_3 PF13385.1 ESS62189.1 - 4.7e-13 49.6 1.9 7.5e-13 49.0 1.3 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3617 PF12276.3 ESS62189.1 - 0.055 12.9 2.8 0.19 11.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3617) Daxx PF03344.10 ESS62192.1 - 0.018 13.5 20.6 0.021 13.3 14.3 1.2 1 0 0 1 1 1 0 Daxx Family BNR_3 PF13859.1 ESS62195.1 - 2.1e-129 431.0 4.0 4.2e-129 430.0 2.8 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62195.1 - 9.1e-15 55.2 1.0 2e-14 54.1 0.7 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily RVT_1 PF00078.22 ESS62196.1 - 3.6e-27 95.1 0.0 4.3e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS62196.1 - 0.039 13.7 0.1 0.13 12.0 0.1 1.9 2 0 0 2 2 2 0 EBP50, C-terminal RNase_H PF00075.19 ESS62197.1 - 7.9e-09 35.9 0.0 1.3e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 RNase H Phe_ZIP PF08916.6 ESS62197.1 - 0.091 13.0 0.1 0.29 11.4 0.0 1.9 2 0 0 2 2 2 0 Phenylalanine zipper DAN PF03045.10 ESS62197.1 - 0.097 12.0 0.1 0.097 12.0 0.0 2.6 2 1 1 3 3 3 0 DAN domain zf-C2H2_jaz PF12171.3 ESS62197.1 - 0.16 12.1 4.6 8.8 6.6 0.7 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 ESS62197.1 - 0.52 10.4 7.8 2.6 8.2 5.4 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 ESS62197.1 - 2.8 8.4 17.3 2.6 8.5 2.0 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS62197.1 - 4.5 7.7 11.9 1.5 9.2 1.2 3.7 3 0 0 3 3 3 0 Zinc-finger double domain DUF2769 PF10967.3 ESS62198.1 - 0.7 10.2 9.2 0.087 13.1 1.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2769) Cellulose_synt PF03552.9 ESS62199.1 - 1.4 7.0 4.2 1.9 6.6 2.9 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF1700 PF08006.6 ESS62199.1 - 2.1 7.6 5.6 2.9 7.1 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Laminin_G_3 PF13385.1 ESS62200.1 - 1.6e-13 51.2 1.6 2.5e-13 50.5 0.3 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62200.1 - 1.3e-10 40.9 12.4 2.7e-10 39.9 8.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62201.1 - 6e-130 432.8 5.5 8.6e-130 432.3 3.8 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62201.1 - 0.0019 17.5 0.1 0.011 15.0 0.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain ASRT PF07100.6 ESS62202.1 - 0.0039 16.9 0.0 0.0053 16.4 0.0 1.2 1 0 0 1 1 1 1 Anabaena sensory rhodopsin transducer DUF1623 PF07785.6 ESS62202.1 - 0.21 11.5 0.8 0.36 10.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) BNR_3 PF13859.1 ESS62203.1 - 2.5e-94 315.8 2.8 4.2e-94 315.1 0.7 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62203.1 - 6e-20 72.0 0.2 1.8e-19 70.5 0.2 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62203.1 - 2.1e-12 46.6 10.4 6.5e-12 45.1 7.2 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal SIP1 PF04938.7 ESS62203.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF605 PF04652.11 ESS62204.1 - 0.27 10.5 11.2 0.32 10.3 7.8 1.1 1 0 0 1 1 1 0 Vta1 like RHSP PF07999.6 ESS62205.1 - 2.1e-105 352.8 0.2 2.1e-105 352.8 0.1 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein DDE_Tnp_1 PF01609.16 ESS62207.1 - 6.7 6.1 8.6 1.4 8.3 3.1 1.8 1 1 1 2 2 2 0 Transposase DDE domain RHSP PF07999.6 ESS62209.1 - 1.3e-101 340.3 0.2 1.3e-101 340.3 0.1 1.4 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS62209.1 - 0.0008 19.5 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 ESS62209.1 - 0.11 11.9 0.1 0.37 10.1 0.1 1.8 2 0 0 2 2 2 0 AAA-like domain ApoLp-III PF07464.6 ESS62210.1 - 0.062 13.3 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF3676 PF12429.3 ESS62211.1 - 1.9e-108 361.4 41.8 2.8e-108 360.8 29.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS62211.1 - 4.2e-79 265.8 0.0 4.2e-79 265.8 0.0 2.5 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62211.1 - 7.9e-11 42.4 1.8 7.9e-11 42.4 1.2 3.0 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62211.1 - 5.9e-10 38.8 4.0 5.9e-10 38.8 2.8 1.8 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Ras PF00071.17 ESS62213.1 - 2.6e-22 78.9 0.0 1.4e-16 60.3 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 ESS62213.1 - 4.8e-18 65.7 0.0 7.5e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS62213.1 - 3.6e-06 26.3 0.0 9.8e-05 21.6 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESS62213.1 - 3.2e-05 23.8 0.0 4.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESS62213.1 - 3.3e-05 23.1 0.0 4.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESS62213.1 - 3.3e-05 23.4 0.0 5.3e-05 22.7 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.14 ESS62213.1 - 0.0015 18.0 0.0 0.38 10.1 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 ESS62213.1 - 0.0036 16.5 0.0 0.0065 15.6 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESS62213.1 - 0.0085 16.2 0.0 0.014 15.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESS62213.1 - 0.01 15.4 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS62213.1 - 0.017 15.1 0.1 0.023 14.6 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain UPF0079 PF02367.12 ESS62213.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 ESS62213.1 - 0.022 14.7 0.0 0.035 14.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 ESS62213.1 - 0.031 14.0 0.0 0.096 12.4 0.0 1.7 2 0 0 2 2 2 0 Dynamin family MobB PF03205.9 ESS62213.1 - 0.032 13.9 0.0 0.097 12.3 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 ESS62213.1 - 0.045 14.0 0.0 0.12 12.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.7 ESS62213.1 - 0.049 13.2 0.1 0.11 12.1 0.0 1.5 2 0 0 2 2 2 0 NACHT domain Septin PF00735.13 ESS62213.1 - 0.084 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_5 PF07728.9 ESS62213.1 - 0.097 12.3 0.0 0.5 10.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.24 ESS62214.1 - 4.4e-35 120.7 0.0 9.4e-35 119.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESS62214.1 - 0.00041 20.3 0.0 0.0011 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESS62214.1 - 0.00055 20.0 0.4 0.21 11.7 0.1 3.2 2 1 1 3 3 3 1 AAA domain AAA_17 PF13207.1 ESS62214.1 - 0.0028 18.4 0.0 0.0088 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS62214.1 - 0.0078 15.9 2.3 0.054 13.2 0.7 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS62214.1 - 0.0084 15.8 1.9 0.024 14.3 1.3 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 ESS62214.1 - 0.0091 15.0 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESS62214.1 - 0.0099 15.8 0.4 0.046 13.6 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 ESS62214.1 - 0.024 14.4 0.1 0.07 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 ESS62214.1 - 0.035 13.2 0.3 0.097 11.8 0.2 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ESS62214.1 - 0.036 14.0 0.0 0.084 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESS62214.1 - 0.063 12.6 2.4 0.079 12.3 0.7 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.1 ESS62214.1 - 0.099 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Baculo_E56 PF04639.7 ESS62214.1 - 0.15 10.6 0.0 0.34 9.5 0.0 1.5 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope Plasmodium_Vir PF05795.6 ESS62214.1 - 0.2 10.8 0.1 0.54 9.3 0.0 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein C2 PF00168.25 ESS62215.1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 C2 domain DUF3719 PF12516.3 ESS62216.1 - 0.094 12.2 1.0 0.22 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) Pkinase PF00069.20 ESS62219.1 - 0.047 12.8 0.0 0.063 12.4 0.0 1.4 1 1 0 1 1 1 0 Protein kinase domain CcmD PF04995.9 ESS62219.1 - 5.1 6.9 5.2 13 5.6 3.6 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) FtsJ PF01728.14 ESS62220.1 - 2.5e-42 144.8 0.0 3.7e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF914 PF06027.7 ESS62223.1 - 1.4e-57 195.0 20.3 3.5e-48 164.1 2.9 2.0 2 0 0 2 2 2 2 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 ESS62223.1 - 1.7e-05 24.8 31.1 0.0004 20.4 6.3 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 ESS62223.1 - 0.0019 17.8 22.0 0.11 12.0 6.2 2.6 2 2 0 2 2 2 2 Triose-phosphate Transporter family SPRY PF00622.23 ESS62226.1 - 1.9e-13 50.6 0.3 6.1e-08 32.7 0.0 4.0 3 0 0 3 3 3 3 SPRY domain HECT PF00632.20 ESS62229.1 - 3.3e-48 164.4 0.1 5.1e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ELFV_dehydrog PF00208.16 ESS62230.1 - 1.9e-85 286.3 3.9 2.4e-85 286.0 2.7 1.0 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.1 ESS62230.1 - 0.00017 21.7 0.2 0.00029 21.0 0.2 1.6 1 1 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.14 ESS62230.1 - 0.00067 18.8 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 ESS62230.1 - 0.0042 16.6 0.0 0.0093 15.5 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.1 ESS62230.1 - 0.017 15.1 0.0 0.05 13.6 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Bac_GDH PF05088.7 ESS62230.1 - 0.025 12.0 0.1 0.032 11.6 0.1 1.1 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase Oxidored_nitro PF00148.14 ESS62230.1 - 0.041 12.5 0.0 0.064 11.8 0.0 1.4 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase CEP44 PF15007.1 ESS62231.1 - 0.00073 19.2 0.0 0.00088 18.9 0.0 1.1 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 UL73_N PF12522.3 ESS62232.1 - 0.13 11.8 0.2 0.13 11.8 0.1 1.9 2 0 0 2 2 2 0 Cytomegalovirus glycoprotein N terminal Glyco_hydro_63 PF03200.11 ESS62233.1 - 2.9e-05 22.1 0.0 3.4e-05 21.9 0.0 1.0 1 0 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Glyco_hydro_63 PF03200.11 ESS62234.1 - 2.4e-40 138.1 0.0 6.7e-40 136.7 0.0 1.6 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Ring_hydroxyl_A PF00848.14 ESS62235.1 - 0.094 12.3 0.0 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) 4HBT_2 PF13279.1 ESS62236.1 - 2.2e-06 28.1 0.1 4.3e-06 27.1 0.1 1.5 1 1 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 ESS62236.1 - 0.00021 21.3 0.1 0.00041 20.4 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.12 ESS62236.1 - 0.066 12.1 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Acyl-ACP thioesterase Sel1 PF08238.7 ESS62238.1 - 0.00079 19.9 9.7 0.21 12.2 0.4 4.8 5 1 0 5 5 5 2 Sel1 repeat Toxin_64 PF15542.1 ESS62238.1 - 1.4 9.4 4.8 2.7 8.5 2.8 1.8 1 1 0 1 1 1 0 Putative toxin 64 HhH-GPD PF00730.20 ESS62239.1 - 1.1e-16 60.9 0.0 2.3e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.1 ESS62239.1 - 1.8e-11 43.4 0.0 4.4e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.18 ESS62239.1 - 1.5e-06 27.5 0.5 6.9e-06 25.4 0.0 2.4 3 0 0 3 3 3 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 ESS62239.1 - 0.00092 19.3 5.4 0.002 18.2 3.8 1.6 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III Drf_FH3 PF06367.11 ESS62239.1 - 0.019 14.3 0.1 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Diaphanous FH3 Domain Cullin PF00888.17 ESS62240.1 - 3.9e-25 88.4 0.1 8.8e-25 87.2 0.0 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 ESS62240.1 - 1.4e-14 53.6 0.0 2.4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.17 ESS62241.1 - 2.1e-24 86.0 0.0 2.4e-24 85.8 0.0 1.0 1 0 0 1 1 1 1 Cullin family UPF0547 PF10571.4 ESS62246.1 - 0.069 12.8 1.2 0.25 11.0 0.9 2.0 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-C2H2_4 PF13894.1 ESS62246.1 - 0.15 12.4 6.4 0.28 11.5 0.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger RNHCP PF12647.2 ESS62246.1 - 0.24 11.2 2.1 1.5 8.6 0.1 2.3 2 0 0 2 2 2 0 RNHCP domain zf-C2H2 PF00096.21 ESS62246.1 - 0.25 11.7 8.1 0.14 12.5 1.0 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESS62246.1 - 0.7 10.3 4.9 5.7 7.4 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger double domain NAD_binding_1 PF00175.16 ESS62247.1 - 1.3e-22 80.4 0.0 2.2e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESS62247.1 - 1.1e-11 44.6 0.0 2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESS62247.1 - 4e-05 23.5 0.0 0.0006 19.7 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Nsp1_C PF05064.8 ESS62248.1 - 4.3e-06 26.3 0.0 1e-05 25.1 0.0 1.5 2 0 0 2 2 2 1 Nsp1-like C-terminal region DUF2959 PF11172.3 ESS62248.1 - 0.035 13.8 0.4 0.053 13.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) ATG16 PF08614.6 ESS62248.1 - 0.043 13.6 4.2 0.089 12.6 2.3 1.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.5 ESS62248.1 - 0.096 12.8 0.2 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Rnk_N PF14760.1 ESS62248.1 - 0.59 10.2 3.6 0.65 10.1 1.3 2.0 2 0 0 2 2 2 0 Rnk N-terminus PPR PF01535.15 ESS62249.1 - 2e-05 24.2 0.7 2.6 8.2 0.0 5.2 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.1 ESS62249.1 - 0.0053 16.9 6.7 14 6.2 0.0 6.5 7 0 0 7 7 7 1 Pentatricopeptide repeat domain TPR_12 PF13424.1 ESS62249.1 - 0.012 15.5 0.1 7.1 6.6 0.0 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.1 ESS62249.1 - 0.018 15.0 0.7 24 5.0 0.0 4.1 3 2 2 5 5 5 0 PPR repeat family Vps39_1 PF10366.4 ESS62249.1 - 0.018 15.0 0.1 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.1 ESS62249.1 - 0.046 13.5 0.0 23 5.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS62249.1 - 0.32 11.5 4.3 97 3.8 0.0 4.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MIP PF00230.15 ESS62250.1 - 1.3e-31 109.8 12.0 1.7e-31 109.4 8.3 1.2 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.15 ESS62251.1 - 2.7e-34 118.5 14.7 3.7e-34 118.1 10.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein HAD_2 PF13419.1 ESS62253.1 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESS62253.1 - 0.002 17.7 0.0 0.0036 16.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hist_deacetyl PF00850.14 ESS62254.1 - 2.2e-58 198.0 0.0 3.5e-58 197.3 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Paf1 PF03985.8 ESS62254.1 - 0.49 9.0 26.1 0.62 8.7 18.1 1.1 1 0 0 1 1 1 0 Paf1 DARPP-32 PF05395.7 ESS62254.1 - 1.6 8.8 19.6 13 5.9 11.2 2.1 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 TEX19 PF15553.1 ESS62254.1 - 2.3 8.0 8.9 4.3 7.1 6.2 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 RNA_pol_Rpc4 PF05132.9 ESS62254.1 - 3.2 7.7 9.9 5.9 6.8 6.9 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.12 ESS62254.1 - 3.3 7.4 11.9 5.7 6.6 8.3 1.3 1 0 0 1 1 1 0 DDHD domain TPR_11 PF13414.1 ESS62255.1 - 2.6e-05 23.7 1.1 0.0017 17.9 0.2 2.5 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.1 ESS62255.1 - 0.00054 19.8 5.4 0.00065 19.5 0.6 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat NIF3 PF01784.13 ESS62255.1 - 0.11 12.0 0.0 11 5.4 0.0 2.4 2 0 0 2 2 2 0 NIF3 (NGG1p interacting factor 3) Nol1_Nop2_Fmu PF01189.12 ESS62257.1 - 1.1e-14 54.5 0.0 1.4e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 ESS62257.1 - 0.0036 17.3 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS62257.1 - 0.022 15.3 0.0 0.034 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NUDIX PF00293.23 ESS62258.1 - 5.6e-07 29.2 0.6 1.3e-06 28.0 0.1 1.9 2 1 0 2 2 2 1 NUDIX domain PAP_assoc PF03828.14 ESS62259.1 - 2.5e-12 46.5 0.0 5.2e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESS62259.1 - 0.00047 20.4 0.1 0.0012 19.1 0.0 1.7 1 1 0 1 1 1 1 Nucleotidyltransferase domain Cpn60_TCP1 PF00118.19 ESS62261.1 - 0.00025 19.8 0.0 0.00034 19.3 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family YchF-GTPase_C PF06071.8 ESS62262.1 - 4.5e-38 128.9 0.9 9.4e-38 127.8 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 ESS62262.1 - 1.4e-16 60.4 0.0 2.4e-16 59.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS62262.1 - 0.00022 20.5 0.0 0.00051 19.3 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_17 PF13207.1 ESS62262.1 - 0.0075 17.0 0.0 0.02 15.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESS62262.1 - 0.0077 16.5 0.0 0.19 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain TGS PF02824.16 ESS62262.1 - 0.0078 16.0 0.1 0.023 14.5 0.0 1.8 2 0 0 2 2 2 1 TGS domain ArgK PF03308.11 ESS62262.1 - 0.027 13.2 0.0 0.037 12.8 0.0 1.3 1 0 0 1 1 1 0 ArgK protein PP2C PF00481.16 ESS62263.1 - 1.5e-76 257.1 0.0 1.8e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESS62263.1 - 2.7e-06 26.9 0.0 9.6e-06 25.1 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C ACOX PF01756.14 ESS62265.1 - 1.8e-10 40.5 0.0 3.5e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Mcp5_PH PF12814.2 ESS62266.1 - 3.6e-12 46.2 1.0 6.8e-12 45.3 0.7 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.24 ESS62266.1 - 0.0041 17.2 0.1 0.0085 16.2 0.1 1.5 1 0 0 1 1 1 1 PH domain Tropomyosin PF00261.15 ESS62267.1 - 0.061 12.4 5.8 0.032 13.3 2.5 1.6 1 1 0 1 1 1 0 Tropomyosin EMG1 PF03587.9 ESS62269.1 - 3e-42 144.2 0.0 3.7e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Atg14 PF10186.4 ESS62270.1 - 2.8e-05 23.2 0.0 0.0001 21.3 0.0 1.9 2 1 0 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 Spt5-NGN PF03439.8 ESS62271.1 - 5.5e-20 70.9 0.3 2e-19 69.1 0.1 2.1 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.24 ESS62271.1 - 1.8e-07 30.5 0.6 0.074 12.7 0.0 3.9 3 0 0 3 3 3 2 KOW motif Spt5_N PF11942.3 ESS62271.1 - 0.00068 20.2 0.2 0.00068 20.2 0.1 2.4 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal RNA_pol_3_Rpc31 PF11705.3 ESS62271.1 - 0.0085 16.0 8.6 0.015 15.2 6.0 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF3166 PF11365.3 ESS62272.1 - 0.0013 19.1 1.5 0.0022 18.3 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3166) Sec2p PF06428.6 ESS62272.1 - 0.0085 15.9 4.1 0.018 14.9 2.7 1.7 1 1 0 1 1 1 1 GDP/GTP exchange factor Sec2p Fib_alpha PF08702.5 ESS62272.1 - 0.025 14.7 3.5 0.043 13.9 2.4 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Spc7 PF08317.6 ESS62272.1 - 0.12 10.9 6.7 0.15 10.6 4.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein MORN PF02493.15 ESS62273.1 - 1.8e-18 65.0 22.9 1.8e-07 30.4 1.7 4.9 6 0 0 6 6 6 4 MORN repeat COG5 PF10392.4 ESS62274.1 - 0.029 14.3 0.1 0.033 14.1 0.1 1.1 1 0 0 1 1 1 0 Golgi transport complex subunit 5 GDE_N_bis PF14742.1 ESS62274.1 - 0.054 12.8 0.1 0.056 12.8 0.1 1.1 1 0 0 1 1 1 0 N-terminal domain of (some) glycogen debranching enzymes Adipogenin PF15202.1 ESS62277.1 - 9.2 6.2 8.4 11 5.9 2.1 2.3 2 0 0 2 2 2 0 Adipogenin Mucin PF01456.12 ESS62278.1 - 2e-42 144.3 46.2 3.3e-42 143.6 32.0 1.3 1 1 0 1 1 1 1 Mucin-like glycoprotein Nop14 PF04147.7 ESS62278.1 - 0.0067 14.4 1.3 0.007 14.3 0.9 1.0 1 0 0 1 1 1 1 Nop14-like family FAM60A PF15396.1 ESS62278.1 - 0.11 12.2 1.0 0.14 11.8 0.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Pex16 PF08610.5 ESS62278.1 - 0.21 10.5 1.6 0.27 10.2 1.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF2413 PF10310.4 ESS62278.1 - 0.73 8.5 7.9 0.79 8.4 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Menin PF05053.8 ESS62278.1 - 0.87 7.6 5.7 0.97 7.5 4.0 1.1 1 0 0 1 1 1 0 Menin Herpes_DNAp_acc PF04929.7 ESS62278.1 - 1.4 7.8 9.1 1.7 7.5 6.3 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor XAP5 PF04921.9 ESS62278.1 - 1.6 8.2 7.2 1.9 7.9 5.0 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Dicty_REP PF05086.7 ESS62278.1 - 3.3 5.3 17.6 4.1 5.0 12.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_S64 PF08192.6 ESS62278.1 - 3.9 5.6 6.2 5.2 5.2 4.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 Filo_glycop PF01611.11 ESS62278.1 - 5.7 5.6 12.5 7 5.3 8.7 1.1 1 0 0 1 1 1 0 Filovirus glycoprotein Aa_trans PF01490.13 ESS62279.1 - 0.045 12.2 0.0 0.066 11.6 0.0 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein BNR_3 PF13859.1 ESS62280.1 - 4.4e-132 439.8 5.5 4.4e-132 439.8 3.8 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62280.1 - 1.3e-16 61.1 1.1 4e-16 59.6 0.8 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62280.1 - 2.1e-07 30.6 10.4 2.1e-07 30.6 7.2 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal AP_endonuc_2_N PF07582.7 ESS62280.1 - 0.016 14.7 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 AP endonuclease family 2 C terminus BNR_3 PF13859.1 ESS62282.1 - 6.5e-120 399.8 2.4 9.3e-120 399.3 1.6 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF3720 PF12517.3 ESS62284.1 - 0.014 16.0 6.7 0.014 16.0 4.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3720) RHSP PF07999.6 ESS62285.1 - 2.8e-55 187.6 0.0 3.6e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS62285.1 - 0.093 12.8 0.1 1.1 9.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain BNR_3 PF13859.1 ESS62287.1 - 1.8e-19 69.9 0.0 2.8e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62287.1 - 2.8e-10 40.6 0.0 5.2e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESS62287.1 - 0.12 12.3 10.8 1.7 8.7 0.7 4.0 4 0 0 4 4 4 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS62288.1 - 1.7e-62 211.3 5.8 1.7e-62 211.3 4.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62288.1 - 1.1e-09 38.7 1.1 4.8e-09 36.6 0.0 2.6 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESS62288.1 - 2.5e-05 23.4 2.3 0.27 11.1 0.1 3.9 2 0 0 2 2 2 2 BNR/Asp-box repeat DUF2538 PF10804.3 ESS62288.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) BNR_3 PF13859.1 ESS62289.1 - 2.6e-41 141.6 0.1 4e-41 141.0 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS62289.1 - 0.029 14.1 1.0 0.097 12.5 0.0 2.5 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS62290.1 - 9.8e-19 67.5 0.0 1.5e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62290.1 - 4.7e-13 49.6 0.7 4.7e-13 49.6 0.5 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62290.1 - 7.9e-10 38.4 6.5 2.2e-09 37.0 4.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DGF-1_5 PF11038.3 ESS62291.1 - 1.5e-161 536.0 18.9 1.5e-161 536.0 13.1 3.0 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS62291.1 - 1.4e-41 140.7 18.3 4.8e-41 138.9 12.7 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS62291.1 - 3e-36 123.1 2.9 1.2e-35 121.2 2.0 2.1 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2207 PF09972.4 ESS62294.1 - 6.5 5.2 6.8 5.7 5.4 4.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3184 PF11380.3 ESS62295.1 - 0 1054.6 14.5 0 1041.7 10.1 3.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3184) BCL_N PF04714.8 ESS62295.1 - 0.11 12.1 0.2 0.32 10.6 0.1 1.8 1 0 0 1 1 1 0 BCL7, N-terminal conserver region Arif-1 PF06770.6 ESS62295.1 - 0.17 11.2 0.2 3.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Actin-rearrangement-inducing factor (Arif-1) Pkinase PF00069.20 ESS62296.1 - 2.8e-63 213.5 0.0 1.2e-60 204.8 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS62296.1 - 5.7e-24 84.5 5.5 9.8e-20 70.7 0.2 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.9 ESS62296.1 - 0.00098 18.2 0.6 0.0038 16.3 0.4 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FCP1_C PF09309.5 ESS62296.1 - 0.011 15.0 1.4 0.017 14.4 1.0 1.2 1 0 0 1 1 1 0 FCP1, C-terminal SPT16 PF08644.6 ESS62296.1 - 0.015 15.1 0.9 0.038 13.8 0.6 1.6 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) DUF4557 PF15101.1 ESS62296.1 - 0.023 14.5 2.3 0.039 13.8 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Ndc1_Nup PF09531.5 ESS62296.1 - 0.042 12.2 0.9 0.057 11.8 0.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup APH PF01636.18 ESS62296.1 - 0.19 11.4 0.0 0.19 11.4 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Phostensin_N PF13916.1 ESS62296.1 - 0.34 10.9 5.0 0.82 9.6 3.4 1.6 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal SAE2 PF08573.5 ESS62296.1 - 1.9 9.2 6.5 13 6.5 2.0 2.3 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus MtrG PF04210.8 ESS62297.1 - 0.52 10.0 3.4 7.5 6.3 0.0 3.5 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Abhydrolase_6 PF12697.2 ESS62298.1 - 0.024 14.5 0.7 0.099 12.5 0.5 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Methyltransf_23 PF13489.1 ESS62300.1 - 4.4e-15 55.7 0.0 7.2e-13 48.5 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 ESS62300.1 - 1.5e-14 54.2 0.1 2.2e-13 50.5 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS62300.1 - 1.1e-11 44.3 0.0 2.2e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESS62300.1 - 6e-08 33.0 0.0 0.00066 20.1 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.1 ESS62300.1 - 1e-05 25.1 0.0 3.1e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS62300.1 - 0.00016 22.0 0.0 0.0049 17.1 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS62300.1 - 0.0019 18.7 0.1 0.31 11.6 0.0 3.1 3 0 0 3 3 3 1 Methyltransferase domain BNR_3 PF13859.1 ESS62302.1 - 4e-64 216.6 0.4 4e-64 216.6 0.3 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62302.1 - 7.7e-19 68.4 2.7 2e-18 67.0 1.8 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62302.1 - 1.5e-08 34.3 10.4 3.3e-08 33.2 7.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS62306.1 - 5.4e-31 107.2 59.4 9.2e-28 96.8 41.1 2.1 1 1 0 1 1 1 1 Mucin-like glycoprotein AJAP1_PANP_C PF15298.1 ESS62306.1 - 0.022 14.6 12.3 0.025 14.4 8.5 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Shisa PF13908.1 ESS62306.1 - 0.11 12.7 7.1 0.13 12.4 4.9 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS62306.1 - 0.12 12.6 1.6 0.13 12.5 1.1 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Pex14_N PF04695.8 ESS62306.1 - 0.15 12.1 5.3 0.17 11.9 3.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1180 PF06679.7 ESS62306.1 - 4.2 7.2 11.9 11 5.8 8.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) PRCC PF10253.4 ESS62306.1 - 6 7.5 6.4 6.8 7.3 4.4 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF4634 PF15465.1 ESS62307.1 - 0.013 15.6 0.6 0.054 13.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) Pex14_N PF04695.8 ESS62309.1 - 0.36 10.8 4.8 0.17 11.9 1.4 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF605 PF04652.11 ESS62310.1 - 0.16 11.3 16.6 0.2 10.9 11.5 1.0 1 0 0 1 1 1 0 Vta1 like Laminin_G_3 PF13385.1 ESS62312.1 - 2e-15 57.3 0.2 3.7e-15 56.4 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62312.1 - 1.3e-07 31.3 9.2 3.1e-07 30.1 6.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62312.1 - 0.015 14.3 0.0 0.031 13.3 0.0 1.5 1 0 0 1 1 1 0 BNR repeat-like domain Suppressor_P21 PF11479.3 ESS62313.1 - 0.13 12.0 0.1 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 RNA silencing suppressor P21 BNR_3 PF13859.1 ESS62314.1 - 4.7e-75 252.5 0.7 6.9e-75 251.9 0.5 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62314.1 - 0.01 15.1 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 0 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62315.1 - 1.2e-12 48.3 0.2 3.3e-12 46.9 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62315.1 - 4.5e-11 42.4 12.0 4.5e-11 42.4 8.3 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4131 PF13567.1 ESS62318.1 - 6.9 6.0 7.8 12 5.3 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) BNR_3 PF13859.1 ESS62321.1 - 3.4e-63 213.5 0.8 7.1e-63 212.5 0.1 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62321.1 - 1.4e-15 57.8 3.7 1.8e-15 57.5 1.8 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62321.1 - 3.1e-08 33.3 10.6 6.7e-08 32.2 7.4 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62322.1 - 1.5e-38 132.6 0.0 2.4e-38 131.9 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain LCE PF14672.1 ESS62325.1 - 2.1 8.8 13.5 1.1 9.7 0.6 2.2 2 0 0 2 2 2 0 Late cornified envelope YadA_stalk PF05662.9 ESS62326.1 - 3.2 7.6 5.2 2.3 8.1 0.1 2.6 2 0 0 2 2 2 0 Coiled stalk of trimeric autotransporter adhesin BNR_3 PF13859.1 ESS62328.1 - 5.4e-131 436.2 6.6 5.4e-131 436.2 4.6 1.9 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62328.1 - 4.9e-17 62.6 0.4 1.6e-16 60.9 0.3 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62328.1 - 1.2e-10 41.0 11.1 2.8e-10 39.8 7.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62330.1 - 5.4e-08 32.2 0.0 1.3e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 BNR repeat-like domain DUF3005 PF11448.3 ESS62330.1 - 0.0046 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3005) BNR_3 PF13859.1 ESS62332.1 - 4.7e-105 351.0 3.1 5.9e-105 350.7 2.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62333.1 - 1.8e-15 57.4 0.2 1.8e-15 57.4 0.1 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62333.1 - 5.3e-11 42.1 8.7 1.6e-10 40.6 6.1 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Exo_endo_phos_2 PF14529.1 ESS62335.1 - 5.7e-18 64.6 0.0 8.2e-18 64.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS62335.1 - 1.4e-09 38.2 0.1 2.1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4272 PF14094.1 ESS62336.1 - 0.011 14.7 3.0 0.023 13.6 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) PH PF00169.24 ESS62336.1 - 0.016 15.4 0.3 0.58 10.3 0.0 2.9 3 1 0 3 3 3 0 PH domain Sp38 PF07354.7 ESS62336.1 - 0.11 11.1 0.1 0.21 10.2 0.1 1.4 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) RHSP PF07999.6 ESS62337.1 - 9.8e-75 251.7 0.6 2.1e-74 250.7 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein CCER1 PF15482.1 ESS62339.1 - 0.25 10.9 1.0 0.27 10.8 0.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 GDC-P PF02347.11 ESS62340.1 - 7e-36 123.8 0.1 9.9e-36 123.3 0.1 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Aminotran_5 PF00266.14 ESS62340.1 - 0.12 11.0 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class-V RHSP PF07999.6 ESS62341.1 - 2.9e-20 72.2 0.3 7.6e-18 64.3 0.0 2.0 2 0 0 2 2 2 2 Retrotransposon hot spot protein rpo132 PF12415.3 ESS62341.1 - 0.088 11.7 0.0 0.22 10.5 0.0 1.6 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase PH PF00169.24 ESS62342.1 - 0.0027 17.8 1.1 0.14 12.3 0.0 2.9 3 0 0 3 3 3 1 PH domain DUF4417 PF14386.1 ESS62342.1 - 0.071 12.4 0.6 0.35 10.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4417) Complex1_LYR_2 PF13233.1 ESS62342.1 - 0.16 12.4 14.3 1.1 9.7 4.4 3.0 1 1 1 2 2 2 0 Complex1_LYR-like CCAP PF11105.3 ESS62343.1 - 0.074 12.7 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a BNR_3 PF13859.1 ESS62347.1 - 2.7e-89 299.3 4.9 3.1e-89 299.1 3.4 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62347.1 - 0.0051 16.1 0.1 0.0079 15.5 0.1 1.5 1 1 0 1 1 1 1 BNR repeat-like domain PTPlike_phytase PF14566.1 ESS62347.1 - 0.013 15.5 0.1 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Glyco_hydro_32N PF00251.15 ESS62347.1 - 0.09 12.1 0.0 10 5.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain BNR_3 PF13859.1 ESS62348.1 - 2e-29 102.6 0.2 4.3e-29 101.5 0.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62348.1 - 3.6e-19 69.5 0.7 5.4e-19 68.9 0.5 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 ESS62348.1 - 0.074 13.0 0.3 0.15 12.0 0.2 1.5 1 0 0 1 1 1 0 Laminin G domain BNR_3 PF13859.1 ESS62351.1 - 2.2e-129 430.9 6.8 2.2e-129 430.9 4.7 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62351.1 - 4.6e-16 59.4 0.0 1.5e-15 57.7 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62351.1 - 2e-07 30.7 11.5 5.4e-07 29.3 8.0 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS62351.1 - 0.1 12.4 0.6 32 4.9 0.0 3.6 2 0 0 2 2 2 0 BNR/Asp-box repeat Peptidase_M8 PF01457.11 ESS62353.1 - 5.3e-07 28.3 0.5 6.7e-07 28.0 0.3 1.0 1 0 0 1 1 1 1 Leishmanolysin Mucin PF01456.12 ESS62355.1 - 6.8e-41 139.3 46.6 2.6e-27 95.3 24.3 2.1 1 1 1 2 2 2 2 Mucin-like glycoprotein DUF3811 PF11656.3 ESS62355.1 - 0.65 10.0 9.5 0.7 10.0 5.9 1.5 1 1 0 1 1 1 0 YjbD family (DUF3811) HeLo PF14479.1 ESS62355.1 - 2.2 7.9 8.1 2.7 7.7 5.3 1.4 1 1 0 1 1 1 0 Prion-inhibition and propagation Defensin_propep PF00879.13 ESS62355.1 - 9.9 6.2 7.5 1.2 9.1 0.6 2.7 2 1 0 2 2 2 0 Defensin propeptide BNR_3 PF13859.1 ESS62356.1 - 1.2e-31 109.9 1.1 2.4e-31 108.9 0.2 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62356.1 - 3e-09 37.3 0.2 6e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF2228 PF10228.4 ESS62357.1 - 0.07 12.6 2.2 0.076 12.5 1.5 1.0 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) DUF4094 PF13334.1 ESS62357.1 - 0.21 11.9 1.5 0.26 11.6 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF1090 PF06476.7 ESS62357.1 - 0.23 11.1 8.4 0.7 9.5 5.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1090) Tom37_C PF11801.3 ESS62357.1 - 0.76 9.6 3.8 0.83 9.5 2.6 1.0 1 0 0 1 1 1 0 Tom37 C-terminal domain Sec62 PF03839.11 ESS62357.1 - 4.1 6.7 6.8 4.1 6.7 4.7 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Mucin PF01456.12 ESS62361.1 - 3.8e-32 111.0 59.0 3.8e-25 88.3 25.0 2.1 1 1 1 2 2 2 2 Mucin-like glycoprotein AJAP1_PANP_C PF15298.1 ESS62361.1 - 0.022 14.6 11.8 0.025 14.4 8.2 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Shisa PF13908.1 ESS62361.1 - 0.076 13.1 6.9 0.095 12.8 4.8 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2360 PF10152.4 ESS62361.1 - 0.1 12.8 1.6 0.11 12.7 1.1 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Pex14_N PF04695.8 ESS62361.1 - 0.11 12.4 4.7 0.13 12.2 3.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1180 PF06679.7 ESS62361.1 - 4.1 7.2 11.7 8.2 6.2 8.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4634 PF15465.1 ESS62362.1 - 0.012 15.7 0.4 0.038 14.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) W2 PF02020.13 ESS62362.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon BNR_3 PF13859.1 ESS62363.1 - 7.2e-131 435.8 5.9 1.3e-130 435.0 4.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62363.1 - 1.2e-15 58.1 0.1 4.3e-15 56.2 0.1 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62363.1 - 4.9e-09 35.9 2.0 1.3e-08 34.5 1.4 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62368.1 - 5.7e-129 429.6 5.9 5.7e-129 429.6 4.1 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62368.1 - 4e-16 59.6 1.2 1.2e-15 58.1 0.8 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62368.1 - 1.5e-10 40.7 12.0 1.5e-10 40.7 8.3 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3584 PF12128.3 ESS62370.1 - 4.6 4.4 13.0 6.4 3.9 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4371 PF14291.1 ESS62373.1 - 0.055 13.0 0.1 0.062 12.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Rtf2 PF04641.7 ESS62373.1 - 0.057 12.6 0.7 0.059 12.5 0.5 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Mucin PF01456.12 ESS62373.1 - 0.076 12.7 8.0 0.087 12.5 5.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Cytochrome-c551 PF10643.4 ESS62373.1 - 1 8.6 4.5 1.1 8.4 3.1 1.1 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 TrbI PF03743.9 ESS62373.1 - 1.6 8.1 5.6 1.9 7.9 3.9 1.1 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein Rifin_STEVOR PF02009.11 ESS62373.1 - 6.7 6.2 7.1 8.1 5.9 4.9 1.3 1 0 0 1 1 1 0 Rifin/stevor family BNR_3 PF13859.1 ESS62375.1 - 2.6e-128 427.4 6.8 4.8e-128 426.5 4.7 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62375.1 - 1.5e-16 61.0 3.9 1.5e-16 61.0 2.7 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62375.1 - 3.5e-09 36.3 10.1 8.8e-09 35.0 7.0 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Alginate_exp PF13372.1 ESS62375.1 - 0.049 12.2 0.1 0.08 11.5 0.1 1.3 1 0 0 1 1 1 0 Alginate export Cas_TM1802 PF09484.5 ESS62375.1 - 0.064 11.7 0.2 0.091 11.2 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein TM1802 (cas_TM1802) DUF1317 PF07026.6 ESS62379.1 - 0.16 11.8 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1317) Mito_fiss_reg PF05308.6 ESS62382.1 - 7.7 5.7 6.1 13 5.0 4.3 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DGF-1_5 PF11038.3 ESS62384.1 - 1.7e-156 519.5 18.5 2.9e-156 518.7 12.8 1.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS62384.1 - 9.2e-50 166.4 2.9 2e-49 165.4 2.0 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS62384.1 - 6e-39 132.2 13.3 1.6e-38 130.9 9.2 1.8 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Aldedh PF00171.17 ESS62385.1 - 9.3e-97 324.2 0.0 1.1e-96 323.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Herpes_Helicase PF02689.9 ESS62385.1 - 0.2 9.3 0.0 0.36 8.5 0.0 1.3 1 0 0 1 1 1 0 Helicase zf-CCCH PF00642.19 ESS62386.1 - 3.8e-08 32.8 7.5 0.00029 20.4 1.7 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHC PF00098.18 ESS62386.1 - 1.4e-06 27.9 0.5 1.4e-06 27.9 0.3 2.3 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESS62386.1 - 0.0001 21.7 3.1 0.00018 20.8 2.2 1.4 1 0 0 1 1 1 1 Zinc knuckle RRM_1 PF00076.17 ESS62386.1 - 0.069 12.7 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRV_FeS PF05484.6 ESS62386.1 - 3 7.4 6.0 15 5.2 0.3 2.4 2 0 0 2 2 2 0 LRV protein FeS4 cluster Apis_Csd PF11671.3 ESS62386.1 - 3.2 7.5 8.9 4.3 7.1 4.4 2.0 2 0 0 2 2 2 0 Complementary sex determiner protein zf-C2H2_3 PF13878.1 ESS62387.1 - 3.2e-09 36.1 0.1 6.2e-09 35.2 0.1 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO ABC_tran PF00005.22 ESS62388.1 - 8.9e-46 155.5 0.8 1.6e-21 77.0 0.0 3.7 3 1 0 3 3 3 2 ABC transporter ABC_tran_2 PF12848.2 ESS62388.1 - 6.5e-24 83.5 8.7 6.5e-24 83.5 6.1 3.5 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.1 ESS62388.1 - 5.7e-18 65.8 5.4 0.0001 22.4 0.8 4.5 3 1 1 4 4 4 4 AAA domain SMC_N PF02463.14 ESS62388.1 - 9.4e-08 31.5 3.9 0.086 12.0 0.0 4.3 1 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.18 ESS62388.1 - 3e-07 30.4 0.2 0.036 14.0 0.0 3.7 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.1 ESS62388.1 - 1.2e-06 27.9 0.3 0.059 12.8 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ESS62388.1 - 7e-06 25.3 0.1 0.064 12.4 0.0 2.7 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESS62388.1 - 1.8e-05 25.5 3.1 0.0039 18.0 0.1 3.8 4 1 0 4 4 2 1 AAA domain AAA_16 PF13191.1 ESS62388.1 - 2.7e-05 24.2 6.7 0.0044 17.0 0.4 3.1 2 2 1 3 3 3 2 AAA ATPase domain Miro PF08477.8 ESS62388.1 - 6.4e-05 23.4 0.0 0.068 13.6 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein SbcCD_C PF13558.1 ESS62388.1 - 0.00085 19.1 0.2 0.18 11.7 0.1 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit MobB PF03205.9 ESS62388.1 - 0.0016 18.1 0.0 0.43 10.2 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 ESS62388.1 - 0.0021 17.7 0.0 0.56 9.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 ESS62388.1 - 0.0029 17.7 3.0 0.29 11.2 0.2 3.8 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESS62388.1 - 0.003 17.4 0.0 4.6 7.1 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 ESS62388.1 - 0.0035 17.6 4.6 0.06 13.6 0.0 4.1 5 0 0 5 5 4 1 AAA domain AAA_15 PF13175.1 ESS62388.1 - 0.005 15.9 7.1 0.52 9.2 0.0 4.3 3 1 2 5 5 5 1 AAA ATPase domain AAA_25 PF13481.1 ESS62388.1 - 0.006 16.0 0.0 2.6 7.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESS62388.1 - 0.0071 16.2 7.6 1.9 8.3 0.0 3.9 3 1 0 3 3 2 2 AAA domain AAA PF00004.24 ESS62388.1 - 0.0082 16.3 1.3 0.39 10.9 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ESS62388.1 - 0.0094 16.1 0.1 5.9 7.1 0.0 2.9 3 0 0 3 3 2 0 RNA helicase ArgK PF03308.11 ESS62388.1 - 0.011 14.5 1.8 0.78 8.4 0.0 2.9 3 0 0 3 3 3 0 ArgK protein Septin PF00735.13 ESS62388.1 - 0.011 14.7 1.6 6.5 5.6 0.0 3.3 3 0 0 3 3 3 0 Septin AAA_30 PF13604.1 ESS62388.1 - 0.014 15.0 0.0 0.72 9.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 ESS62388.1 - 0.014 14.2 0.0 1.7 7.4 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.1 ESS62388.1 - 0.024 14.9 0.1 0.024 14.9 0.1 4.3 5 0 0 5 5 5 0 AAA domain AAA_28 PF13521.1 ESS62388.1 - 0.03 14.3 0.0 0.03 14.3 0.0 3.3 4 0 0 4 4 3 0 AAA domain PduV-EutP PF10662.4 ESS62388.1 - 0.03 13.7 0.2 0.14 11.6 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.21 ESS62388.1 - 0.039 13.4 0.0 10 5.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.10 ESS62388.1 - 0.04 13.6 0.0 8 6.1 0.0 2.9 3 0 0 3 3 2 0 NTPase AAA_5 PF07728.9 ESS62388.1 - 0.051 13.3 0.2 3.6 7.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.14 ESS62388.1 - 0.061 12.7 0.1 0.39 10.1 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 ESS62388.1 - 0.081 12.7 7.3 13 5.5 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function DUF87 AAA_10 PF12846.2 ESS62388.1 - 0.11 11.8 2.7 5 6.4 0.0 3.3 3 1 0 3 3 3 0 AAA-like domain AAA_24 PF13479.1 ESS62388.1 - 0.11 11.9 3.5 6.5 6.2 0.1 3.6 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.18 ESS62388.1 - 0.14 11.9 3.6 3.5 7.4 0.0 3.7 4 0 0 4 4 4 0 Dynamin family LRR_4 PF12799.2 ESS62389.1 - 3.3e-17 61.6 13.0 5.7e-06 25.8 0.8 4.7 3 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESS62389.1 - 4e-09 36.2 1.1 3.7e-06 26.6 0.1 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.1 ESS62389.1 - 9.3e-07 28.5 18.7 0.0023 17.6 0.7 3.7 2 1 1 3 3 3 3 Leucine rich repeat Tup_N PF08581.5 ESS62389.1 - 1.5e-05 25.1 8.5 0.036 14.2 1.7 2.6 1 1 0 2 2 2 2 Tup N-terminal LRR_6 PF13516.1 ESS62389.1 - 0.00012 21.8 12.3 7.8 6.9 0.2 6.3 3 3 3 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.28 ESS62389.1 - 0.00021 20.8 17.6 2.2 8.6 0.1 7.3 7 0 0 7 7 7 2 Leucine Rich Repeat FNIP PF05725.7 ESS62389.1 - 0.0006 19.7 0.2 0.058 13.3 0.0 2.5 2 1 1 3 3 3 2 FNIP Repeat LRR_7 PF13504.1 ESS62389.1 - 0.0011 18.8 12.3 6.1 7.5 0.1 6.9 7 0 0 7 7 7 1 Leucine rich repeat G5 PF07501.7 ESS62389.1 - 0.056 13.4 0.1 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 G5 domain DUF4172 PF13776.1 ESS62389.1 - 0.071 13.2 0.8 0.33 11.0 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4172) Sec2p PF06428.6 ESS62389.1 - 0.32 10.8 8.5 0.24 11.2 2.1 2.8 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF4407 PF14362.1 ESS62389.1 - 1 8.2 9.4 0.72 8.7 1.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Rootletin PF15035.1 ESS62389.1 - 2.7 7.9 18.7 0.35 10.8 6.7 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FlbT PF07378.6 ESS62390.1 - 0.054 13.3 0.2 0.098 12.5 0.1 1.4 1 0 0 1 1 1 0 Flagellar protein FlbT CH PF00307.26 ESS62391.1 - 0.00064 19.7 0.0 0.0017 18.3 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.3 ESS62391.1 - 0.089 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain DNA_primase_lrg PF04104.9 ESS62392.1 - 2.2e-80 269.6 0.0 2.9e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit 7tm_6 PF02949.15 ESS62393.1 - 0.0073 15.2 0.8 0.0086 14.9 0.3 1.3 1 1 0 1 1 1 1 7tm Odorant receptor ETRAMP PF09716.5 ESS62393.1 - 0.3 11.0 0.0 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Acyltransferase PF01553.16 ESS62394.1 - 2.7e-14 52.7 0.0 1.8e-13 50.0 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase PRP21_like_P PF12230.3 ESS62394.1 - 0.0085 15.6 0.5 0.016 14.7 0.3 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Met_10 PF02475.11 ESS62397.1 - 4.3e-38 130.9 0.0 1.8e-34 119.1 0.0 2.2 2 0 0 2 2 2 2 Met-10+ like-protein Methyltransf_18 PF12847.2 ESS62397.1 - 0.00025 21.6 0.0 0.00068 20.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS62397.1 - 0.00088 19.2 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DSPc PF00782.15 ESS62398.1 - 2.6e-06 27.0 0.3 5.5e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 ESS62398.1 - 6.3e-05 23.2 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESS62398.1 - 0.00015 21.1 0.0 0.00028 20.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESS62398.1 - 0.0019 18.2 0.1 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Myosin_head PF00063.16 ESS62399.1 - 7.5e-192 639.0 0.9 2.5e-191 637.2 0.6 1.7 1 1 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.22 ESS62399.1 - 1.8e-05 23.9 0.6 0.00048 19.5 0.1 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif Hpr_kinase_C PF07475.7 ESS62399.1 - 0.054 12.8 0.2 3.2 7.0 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.1 ESS62399.1 - 0.064 13.4 0.0 0.31 11.1 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESS62399.1 - 0.19 11.5 0.0 0.54 10.0 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_17 PF13207.1 ESS62399.1 - 1.2 9.9 0.0 1.2 9.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain Methyltransf_28 PF02636.12 ESS62401.1 - 3.4e-37 128.2 0.0 4.7e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.15 ESS62401.1 - 7.3e-05 21.9 0.0 0.00012 21.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.2 ESS62401.1 - 0.00028 21.4 0.0 0.0006 20.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS62401.1 - 0.0036 17.3 0.0 0.0089 16.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 ESS62401.1 - 0.0044 15.9 0.0 0.0067 15.3 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_31 PF13847.1 ESS62401.1 - 0.0045 16.5 0.0 0.0077 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS62401.1 - 0.023 15.1 0.0 0.049 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 ESS62401.1 - 0.031 13.9 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain N6_Mtase PF02384.11 ESS62401.1 - 0.2 10.6 0.0 0.31 10.0 0.0 1.1 1 0 0 1 1 1 0 N-6 DNA Methylase zf-DHHC PF01529.15 ESS62402.1 - 1.2e-31 109.4 10.6 1.2e-31 109.4 7.3 1.9 1 1 1 2 2 2 1 DHHC palmitoyltransferase IncA PF04156.9 ESS62402.1 - 0.77 9.3 0.0 0.77 9.3 0.0 2.6 3 0 0 3 3 3 0 IncA protein polyprenyl_synt PF00348.12 ESS62403.1 - 4.2e-49 166.7 0.0 5.5e-49 166.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Ribosomal_L28e PF01778.12 ESS62405.1 - 2.6e-27 95.5 0.0 5e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.9 ESS62405.1 - 1.2e-14 54.2 16.9 1.2e-14 54.2 11.7 1.9 2 0 0 2 2 2 1 Mak16 protein C-terminal region Cdc6_C PF09079.6 ESS62406.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal MORN PF02493.15 ESS62407.1 - 5.9e-18 63.4 34.6 4.7e-05 22.8 1.5 5.4 5 0 0 5 5 5 5 MORN repeat EF-hand_1 PF00036.27 ESS62408.1 - 1.4e-16 58.4 4.8 6.6e-09 34.4 0.8 2.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 ESS62408.1 - 2.4e-15 55.8 2.5 7.7e-13 47.8 0.4 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 ESS62408.1 - 1.2e-13 50.9 0.6 1.5e-13 50.6 0.4 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 ESS62408.1 - 1.6e-12 46.1 4.1 7e-06 25.1 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 ESS62408.1 - 8.6e-12 43.8 1.6 2.9e-05 23.5 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.1 ESS62408.1 - 1.9e-08 34.0 0.0 2.6e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 ESS62408.1 - 0.0023 17.6 1.2 0.01 15.5 0.8 1.7 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand DUF3911 PF13050.1 ESS62408.1 - 0.043 13.9 0.1 0.053 13.6 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3911) MIP PF00230.15 ESS62409.1 - 4.6e-26 91.6 16.7 2.8e-25 89.0 11.5 1.9 1 1 0 1 1 1 1 Major intrinsic protein Peptidase_U4 PF03419.8 ESS62409.1 - 6.2 5.7 9.3 4.7 6.1 5.3 1.6 1 1 0 1 1 1 0 Sporulation factor SpoIIGA PsbQ PF05757.6 ESS62411.1 - 0.0026 17.1 2.1 0.003 17.0 1.5 1.0 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) Mito_fiss_reg PF05308.6 ESS62411.1 - 0.046 13.0 1.9 0.049 12.9 1.3 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Peptidase_M17_N PF02789.12 ESS62411.1 - 0.097 12.4 2.0 0.12 12.0 1.4 1.2 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain DUF3987 PF13148.1 ESS62411.1 - 0.18 10.3 9.9 0.2 10.1 6.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) PmbA_TldD PF01523.11 ESS62411.1 - 0.32 10.2 3.3 0.36 10.0 2.3 1.0 1 0 0 1 1 1 0 Putative modulator of DNA gyrase MAP2_projctn PF08377.5 ESS62411.1 - 2.7 5.4 5.6 3.1 5.2 3.9 1.0 1 0 0 1 1 1 0 MAP2/Tau projection domain CAP_N PF01213.14 ESS62411.1 - 3.5 6.8 6.7 3.7 6.7 4.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Dscam_C PF12355.3 ESS62411.1 - 3.5 7.8 6.5 2.5 8.3 3.3 1.6 1 1 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal TPR_2 PF07719.12 ESS62412.1 - 0.0014 18.4 3.8 0.91 9.6 0.7 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS62412.1 - 0.0047 16.8 2.6 0.3 11.0 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS62412.1 - 0.017 15.7 0.9 2.7 8.8 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESS62412.1 - 0.018 14.6 2.9 0.16 11.6 0.2 2.4 2 0 0 2 2 2 0 TPR repeat MAM33 PF02330.11 ESS62413.1 - 2.9e-12 46.7 0.3 3.2e-12 46.6 0.2 1.3 1 1 0 1 1 1 1 Mitochondrial glycoprotein Phage_int_SAM_4 PF13495.1 ESS62415.1 - 0.12 12.7 0.1 0.42 10.9 0.0 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Glycophorin_A PF01102.13 ESS62418.1 - 0.055 13.2 0.1 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A Viral_Beta_CD PF04530.7 ESS62418.1 - 0.11 12.7 0.3 0.13 12.4 0.2 1.1 1 0 0 1 1 1 0 Viral Beta C/D like family Viral_NABP PF05515.6 ESS62419.1 - 0.088 13.0 5.4 0.11 12.7 3.6 1.4 1 1 0 1 1 1 0 Viral nucleic acid binding FA_hydroxylase PF04116.8 ESS62419.1 - 0.14 12.5 6.1 5.6 7.3 0.1 2.7 2 0 0 2 2 2 0 Fatty acid hydroxylase superfamily Herpes_DNAp_acc PF04929.7 ESS62421.1 - 6.3 5.6 6.6 7.7 5.3 4.6 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor UAA PF08449.6 ESS62422.1 - 0.21 10.4 1.8 0.24 10.2 1.3 1.0 1 0 0 1 1 1 0 UAA transporter family BNR_3 PF13859.1 ESS62423.1 - 8.7e-133 442.1 2.9 8.7e-133 442.1 2.0 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62423.1 - 3.2e-15 56.6 2.6 3.2e-15 56.6 1.8 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62423.1 - 4.5e-09 36.0 11.0 1.2e-08 34.6 7.6 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RVT_1 PF00078.22 ESS62425.1 - 1.9e-05 24.1 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4551 PF15087.1 ESS62427.1 - 0.16 10.2 0.3 0.2 9.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Exo_endo_phos_2 PF14529.1 ESS62430.1 - 3.3e-07 29.9 0.0 5.6e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase BNR_3 PF13859.1 ESS62432.1 - 4.1e-73 246.1 0.6 4.1e-73 246.1 0.4 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62432.1 - 9.6e-17 61.6 1.6 2.4e-16 60.3 1.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62432.1 - 1.1e-11 44.4 10.5 2.3e-11 43.3 7.3 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS62432.1 - 0.0017 17.8 1.7 2.4 8.3 0.2 3.4 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_3 PF13859.1 ESS62433.1 - 7.3e-24 84.3 0.3 9.8e-24 83.9 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS62438.1 - 7.2e-21 74.4 21.3 1.5e-20 73.4 14.8 1.5 1 1 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.6 ESS62438.1 - 0.00034 18.7 12.3 0.00035 18.7 8.6 1.1 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 DUF3439 PF11921.3 ESS62438.1 - 0.00066 19.4 11.9 0.00078 19.1 8.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) DUF4658 PF15555.1 ESS62438.1 - 0.091 12.6 0.2 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) Dicty_REP PF05086.7 ESS62438.1 - 0.53 7.9 6.4 0.57 7.8 4.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MGC-24 PF05283.6 ESS62438.1 - 0.6 9.8 8.6 0.61 9.8 6.0 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) TMEM154 PF15102.1 ESS62438.1 - 1.2 8.8 3.9 1.3 8.7 2.7 1.1 1 0 0 1 1 1 0 TMEM154 protein family Enolase_N PF03952.11 ESS62439.1 - 0.1 12.5 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Enolase, N-terminal domain DNA_pol_viral_C PF00336.13 ESS62443.1 - 0.00038 19.8 0.0 0.001 18.4 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase (viral) C-terminal domain RVT_3 PF13456.1 ESS62443.1 - 0.059 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like RNase_H PF00075.19 ESS62443.1 - 0.12 12.7 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 RNase H Dak2 PF02734.12 ESS62446.1 - 0.19 11.3 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 DAK2 domain GCS PF03074.11 ESS62448.1 - 1.8e-170 566.9 0.3 1.8e-170 566.9 0.2 1.6 2 0 0 2 2 2 1 Glutamate-cysteine ligase DnaJ PF00226.26 ESS62449.1 - 3.8e-15 55.3 0.7 3.8e-14 52.1 0.1 2.7 3 0 0 3 3 3 1 DnaJ domain TPR_11 PF13414.1 ESS62449.1 - 8.3e-05 22.1 0.7 8.3e-05 22.1 0.5 4.2 4 1 1 5 5 5 1 TPR repeat TPR_16 PF13432.1 ESS62449.1 - 0.013 16.1 1.1 0.35 11.6 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESS62449.1 - 0.027 14.6 3.3 0.99 9.5 0.3 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Peptidase_S30 PF01577.11 ESS62449.1 - 1.5 8.1 5.5 0.8 9.0 0.6 2.1 1 1 1 2 2 2 0 Potyvirus P1 protease DUF420 PF04238.7 ESS62450.1 - 1.2 9.1 6.3 1.3 8.9 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF420) PepSY_TM PF03929.11 ESS62450.1 - 7.1 7.2 10.0 12 6.5 4.2 2.6 2 1 0 2 2 2 0 PepSY-associated TM helix EF-hand_1 PF00036.27 ESS62451.1 - 0.0098 15.1 0.0 0.024 13.9 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_9 PF14658.1 ESS62451.1 - 0.017 15.0 0.0 0.48 10.3 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain EF-hand_6 PF13405.1 ESS62451.1 - 0.018 14.8 0.1 0.085 12.7 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.1 ESS62451.1 - 0.067 12.8 0.0 0.58 9.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair DUF1682 PF07946.9 ESS62451.1 - 0.63 8.8 10.1 0.26 10.1 4.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) MatE PF01554.13 ESS62453.1 - 2.3e-40 137.8 32.3 1.7e-28 99.3 8.8 2.3 2 0 0 2 2 2 2 MatE Noc2 PF03715.8 ESS62454.1 - 8.2e-99 330.2 0.6 8.2e-99 330.2 0.4 1.8 2 0 0 2 2 2 1 Noc2p family THDPS_M PF14789.1 ESS62454.1 - 0.059 13.3 0.0 0.21 11.5 0.0 2.1 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle TGT PF01702.13 ESS62454.1 - 0.36 10.0 0.0 0.36 10.0 0.0 2.4 3 0 0 3 3 3 0 Queuine tRNA-ribosyltransferase DUF4375 PF14300.1 ESS62454.1 - 5.2 7.0 7.4 5.7 6.9 3.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) HRDC PF00570.18 ESS62455.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 HRDC domain Kinesin PF00225.18 ESS62456.1 - 6.1e-60 202.6 0.1 1e-59 201.9 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Longin PF13774.1 ESS62457.1 - 1.8e-22 78.6 0.0 3e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain UAA PF08449.6 ESS62459.1 - 6.1e-46 156.7 13.7 1.2e-45 155.7 9.5 1.4 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 ESS62459.1 - 9.8e-08 31.7 1.1 9.8e-08 31.7 0.8 3.1 2 1 1 3 3 3 2 Triose-phosphate Transporter family Kinesin PF00225.18 ESS62460.1 - 1.6e-58 198.0 0.0 1.6e-58 198.0 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain AAA_16 PF13191.1 ESS62460.1 - 0.19 11.6 0.0 0.19 11.6 0.0 3.8 2 1 1 4 4 4 0 AAA ATPase domain AAA_22 PF13401.1 ESS62460.1 - 0.23 11.6 5.3 0.35 11.0 0.0 3.3 3 1 1 4 4 4 0 AAA domain FtsK_SpoIIIE PF01580.13 ESS62460.1 - 0.4 10.1 0.0 0.4 10.1 0.0 2.7 3 0 0 3 3 3 0 FtsK/SpoIIIE family DUF87 PF01935.12 ESS62460.1 - 0.58 9.9 0.0 0.58 9.9 0.0 4.1 3 1 0 3 3 3 0 Domain of unknown function DUF87 DUF948 PF06103.6 ESS62460.1 - 2 8.3 11.5 19 5.1 0.0 5.0 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Myosin_tail_1 PF01576.14 ESS62460.1 - 5.3 4.6 64.6 0.014 13.1 12.9 4.1 2 1 2 4 4 4 0 Myosin tail PIH1 PF08190.7 ESS62461.1 - 3.1e-14 53.1 0.3 1.3e-08 34.6 0.0 2.1 2 0 0 2 2 2 2 pre-RNA processing PIH1/Nop17 Pkinase PF00069.20 ESS62462.1 - 8.6e-66 221.7 0.0 1e-65 221.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS62462.1 - 3e-31 108.4 0.0 3.7e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS62462.1 - 3.1e-06 26.3 0.0 4.4e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS62462.1 - 0.0049 16.6 0.2 0.0089 15.7 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Oxidored-like PF09791.4 ESS62463.1 - 1.9e-13 49.6 1.5 3.3e-13 48.8 1.0 1.3 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Herpes_UL32 PF06070.6 ESS62463.1 - 0.19 10.1 0.2 0.23 9.8 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 Bd3614_N PF14442.1 ESS62463.1 - 0.68 9.9 2.6 0.99 9.3 1.8 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal NAD_binding_1 PF00175.16 ESS62464.1 - 1.8e-11 44.5 0.0 3.1e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.15 ESS62464.1 - 0.0047 16.4 0.1 0.0079 15.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_6 PF08030.7 ESS62464.1 - 0.15 11.9 0.0 2.7 7.8 0.0 2.1 1 1 0 2 2 2 0 Ferric reductase NAD binding domain IF4E PF01652.13 ESS62465.1 - 3.1e-38 130.8 0.0 3.9e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TPT PF03151.11 ESS62466.1 - 2.2e-23 82.5 6.7 2.2e-23 82.5 4.6 2.6 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESS62466.1 - 2e-10 40.7 22.7 7e-09 35.7 3.2 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 ESS62466.1 - 6.7e-07 28.5 26.1 1.4e-06 27.5 18.1 1.5 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 ESS62466.1 - 0.033 14.3 20.0 0.44 10.7 2.3 2.9 2 1 1 3 3 3 0 Multidrug resistance efflux transporter MARVEL PF01284.18 ESS62466.1 - 0.95 9.2 18.7 0.094 12.5 5.6 3.0 1 1 1 2 2 2 0 Membrane-associating domain DUF4407 PF14362.1 ESS62467.1 - 0.088 11.7 6.0 0.14 11.1 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IFT57 PF10498.4 ESS62467.1 - 0.12 11.0 2.2 0.19 10.4 1.5 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 RVT_3 PF13456.1 ESS62468.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like IF3_N PF05198.11 ESS62469.1 - 0.0013 18.6 0.0 0.0038 17.1 0.0 1.7 1 1 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain FKBP_C PF00254.23 ESS62470.1 - 7.1e-32 109.2 0.0 2.5e-29 101.1 0.0 2.4 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 ESS62470.1 - 9.3e-15 54.0 0.8 1.6e-07 30.8 0.0 2.6 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS62470.1 - 1.7e-10 40.0 2.2 0.007 16.2 0.4 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS62470.1 - 3e-06 27.0 2.5 0.0048 16.7 0.2 2.8 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 ESS62470.1 - 5.1e-06 25.8 2.1 1.9 8.2 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS62470.1 - 2.7e-05 24.4 1.4 0.26 12.0 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS62470.1 - 0.00062 19.5 3.7 0.00077 19.2 0.4 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS62470.1 - 0.0021 18.6 7.8 0.64 10.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS62470.1 - 0.0026 18.0 0.1 0.11 12.7 0.1 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS62470.1 - 0.01 15.9 0.3 0.087 13.0 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS62470.1 - 0.56 10.1 4.2 8.1 6.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESS62470.1 - 5.9 7.0 10.9 0.62 10.2 0.7 2.6 2 1 1 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Carn_acyltransf PF00755.15 ESS62471.1 - 4.7e-165 550.0 0.0 5.6e-165 549.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase WD40 PF00400.27 ESS62472.1 - 1.1e-14 53.6 0.5 6.8e-06 25.7 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat IMPDH PF00478.20 ESS62473.1 - 2.6e-132 440.9 2.4 3.3e-132 440.6 1.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 ESS62473.1 - 1.8e-13 50.0 0.1 6.8e-06 25.7 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 ESS62473.1 - 7.4e-11 41.7 2.0 1.3e-06 27.7 0.7 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.13 ESS62473.1 - 1.3e-09 37.3 0.4 1.3e-09 37.3 0.3 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 ESS62473.1 - 0.00069 18.9 0.1 0.051 12.8 0.0 2.4 1 1 0 2 2 2 1 Histidine biosynthesis protein Glu_synthase PF01645.12 ESS62473.1 - 0.00094 18.2 0.6 0.0017 17.3 0.4 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase Peptidase_M41 PF01434.13 ESS62474.1 - 3e-42 144.4 0.2 4.4e-42 143.9 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESS62474.1 - 4.6e-40 136.8 0.0 1.2e-39 135.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESS62474.1 - 8.5e-05 22.0 1.4 0.0014 18.0 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.1 ESS62474.1 - 0.00038 20.5 2.2 0.0035 17.4 0.1 3.3 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.9 ESS62474.1 - 0.00044 20.0 0.0 0.0023 17.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS62474.1 - 0.00055 19.6 1.2 0.0018 17.9 0.1 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_16 PF13191.1 ESS62474.1 - 0.00097 19.1 5.9 0.0086 16.0 1.7 3.4 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 ESS62474.1 - 0.0015 17.6 0.0 0.0049 15.9 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ESS62474.1 - 0.0029 18.4 0.2 0.0097 16.7 0.0 2.0 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 ESS62474.1 - 0.011 15.1 0.1 0.025 13.9 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.8 ESS62474.1 - 0.014 14.1 0.0 0.023 13.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus DUF2075 PF09848.4 ESS62474.1 - 0.039 12.9 0.1 0.077 11.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.1 ESS62474.1 - 0.086 13.1 0.1 0.24 11.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.1 ESS62474.1 - 0.091 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ESS62474.1 - 0.11 12.1 0.1 0.55 9.8 0.1 2.1 2 0 0 2 2 2 0 NACHT domain Peptidase_M50B PF13398.1 ESS62474.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase M50B-like BTB_2 PF02214.17 ESS62475.1 - 3.9e-12 46.2 0.0 8.1e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESS62475.1 - 0.0099 15.8 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain JSRP PF15312.1 ESS62476.1 - 0.008 16.1 1.1 0.017 15.1 0.8 1.5 1 0 0 1 1 1 1 Junctional sarcoplasmic reticulum protein DUF368 PF04018.8 ESS62476.1 - 0.057 12.5 6.4 0.073 12.2 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF368) RHSP PF07999.6 ESS62477.1 - 4.7e-81 272.6 0.0 6.6e-81 272.1 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Mucin PF01456.12 ESS62480.1 - 1 9.1 18.8 3 7.6 13.0 2.1 1 1 0 1 1 1 0 Mucin-like glycoprotein Hid1 PF12722.2 ESS62482.1 - 9.1 3.8 6.7 10 3.6 4.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BNR_3 PF13859.1 ESS62484.1 - 7e-131 435.9 1.0 7e-131 435.9 0.7 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62484.1 - 1.4e-19 70.8 1.1 1.4e-19 70.8 0.8 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62484.1 - 5.8e-07 29.2 7.0 5.8e-07 29.2 4.8 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Filaggrin PF03516.8 ESS62485.1 - 6.5 7.2 9.0 15 6.1 0.2 2.2 1 1 1 2 2 2 0 Filaggrin Peptidase_M8 PF01457.11 ESS62486.1 - 1.5e-11 43.3 6.0 7e-10 37.8 4.1 2.0 1 1 0 1 1 1 1 Leishmanolysin PGG PF13962.1 ESS62487.1 - 0.12 11.9 7.2 2.3 7.8 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function zf-C2H2 PF00096.21 ESS62488.1 - 7.8 7.0 6.7 1.4 9.4 0.5 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Mucin PF01456.12 ESS62491.1 - 4e-37 127.1 40.5 8.6e-37 126.0 28.1 1.5 1 1 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.7 ESS62491.1 - 1.2 6.8 13.5 1.5 6.4 9.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.8 ESS62491.1 - 3 5.9 8.9 3.2 5.8 6.1 1.1 1 0 0 1 1 1 0 Menin Laminin_G_3 PF13385.1 ESS62492.1 - 8.5e-12 45.5 0.0 8.5e-12 45.5 0.0 2.0 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62492.1 - 1.7e-09 37.3 13.5 3.4e-09 36.4 9.4 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62493.1 - 2.2e-129 430.9 5.4 3.1e-129 430.4 3.8 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62493.1 - 0.00088 18.6 0.7 0.0035 16.6 0.1 2.1 2 0 0 2 2 2 1 BNR repeat-like domain DUF4407 PF14362.1 ESS62494.1 - 7.3 5.4 6.3 9 5.1 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PBD PF00786.23 ESS62499.1 - 3.5 8.1 4.5 5.5 7.4 3.1 1.6 1 1 0 1 1 1 0 P21-Rho-binding domain YqfQ PF14181.1 ESS62499.1 - 4.8 7.1 19.4 5.2 7.0 13.5 1.2 1 0 0 1 1 1 0 YqfQ-like protein Peptidase_U57 PF05582.7 ESS62499.1 - 5.3 5.9 14.0 6.1 5.7 9.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 GrpE PF01025.14 ESS62499.1 - 5.7 6.4 18.1 6.1 6.3 12.5 1.1 1 0 0 1 1 1 0 GrpE CDC45 PF02724.9 ESS62499.1 - 8 4.3 20.4 7.7 4.4 14.1 1.1 1 0 0 1 1 1 0 CDC45-like protein BNR_3 PF13859.1 ESS62502.1 - 6e-73 245.6 9.8 1.1e-36 126.4 0.1 2.8 2 2 1 3 3 3 2 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62502.1 - 3.1e-16 60.0 0.3 8.8e-16 58.5 0.2 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62502.1 - 1.5e-09 37.5 12.3 3.4e-09 36.3 8.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Tricorn_PDZ PF14685.1 ESS62503.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain Mucin PF01456.12 ESS62505.1 - 1.3e-23 83.3 26.8 1.6e-23 83.0 18.6 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4658 PF15555.1 ESS62505.1 - 0.15 11.9 3.0 0.54 10.1 2.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) MGC-24 PF05283.6 ESS62505.1 - 5.7 6.6 15.9 6.1 6.5 11.0 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) BNR_3 PF13859.1 ESS62507.1 - 2.3e-126 421.0 1.1 2.3e-126 421.0 0.8 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62507.1 - 6e-17 62.3 1.2 6e-17 62.3 0.8 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62507.1 - 4.9e-08 32.7 12.9 9.8e-08 31.7 8.9 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF1623 PF07785.6 ESS62508.1 - 0.069 13.0 0.9 0.11 12.4 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) Corona_S2 PF01601.11 ESS62508.1 - 0.19 9.7 5.1 0.26 9.3 3.6 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein RNase_PH PF01138.16 ESS62510.1 - 6.3e-16 58.8 0.1 1e-15 58.2 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Clathrin PF00637.15 ESS62511.1 - 2.3e-05 24.0 1.7 0.00015 21.3 0.1 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS IF-2B PF01008.12 ESS62513.1 - 2.2e-67 227.0 0.5 2.7e-67 226.7 0.3 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family UPF0029 PF01205.14 ESS62514.1 - 4e-29 100.4 0.1 7.4e-29 99.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 ESS62514.1 - 5.4e-06 26.2 0.0 1.4e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 RWD domain GTSE1_N PF15259.1 ESS62514.1 - 0.068 13.1 0.1 0.29 11.0 0.3 1.8 2 0 0 2 2 2 0 G-2 and S-phase expressed 1 2OG-FeII_Oxy_2 PF13532.1 ESS62515.1 - 8.2e-07 29.0 0.0 3.3e-06 27.0 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MscS_porin PF12795.2 ESS62515.1 - 0.0031 16.8 2.3 0.0053 16.0 1.6 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Lzipper-MIP1 PF14389.1 ESS62515.1 - 0.042 13.9 0.6 0.11 12.6 0.4 1.7 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 NPV_P10 PF05531.7 ESS62515.1 - 0.28 11.4 1.6 3.5 7.9 0.1 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3369 PF11849.3 ESS62516.1 - 0.059 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) DnaJ PF00226.26 ESS62518.1 - 2.6e-10 39.9 0.0 5.2e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain HTH_38 PF13936.1 ESS62518.1 - 0.00015 21.2 0.0 0.00036 20.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESS62518.1 - 0.00047 19.7 0.5 0.0067 16.0 0.0 2.8 2 1 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.1 ESS62518.1 - 0.0016 17.6 0.1 0.0057 15.7 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 KorB PF08535.5 ESS62518.1 - 0.0061 16.6 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 KorB domain HTH_AsnC-type PF13404.1 ESS62518.1 - 0.067 12.7 0.2 0.53 9.8 0.0 2.4 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_29 PF13551.1 ESS62518.1 - 0.15 12.2 3.3 0.45 10.6 0.3 2.7 2 1 0 2 2 2 0 Winged helix-turn helix Tubulin PF00091.20 ESS62520.1 - 2.9e-48 164.5 0.0 3.5e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.1 ESS62520.1 - 0.0026 16.7 0.1 0.0035 16.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin like DAP10 PF07213.6 ESS62521.1 - 0.12 12.0 0.1 0.32 10.7 0.1 1.6 1 0 0 1 1 1 0 DAP10 membrane protein MU117 PF15474.1 ESS62521.1 - 0.13 12.7 0.1 0.45 11.0 0.0 1.9 2 1 0 2 2 2 0 Meiotically up-regulated gene family FlaC_arch PF05377.6 ESS62522.1 - 0.022 14.6 0.1 4.1 7.3 0.0 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) V-SNARE PF05008.10 ESS62522.1 - 0.077 13.1 0.2 0.41 10.8 0.1 2.0 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DEAD PF00270.24 ESS62523.1 - 0.14 11.6 1.9 0.59 9.5 0.0 2.6 2 1 1 3 3 3 0 DEAD/DEAH box helicase MIP-T3 PF10243.4 ESS62523.1 - 9.5 4.5 21.0 15 3.9 14.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Fucokinase PF07959.7 ESS62524.1 - 7.5e-48 163.1 0.0 1.2e-46 159.1 0.0 2.0 1 1 0 1 1 1 1 L-fucokinase GHMP_kinases_N PF00288.21 ESS62524.1 - 5.5e-07 29.5 0.8 1.7e-06 28.0 0.5 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain MbtH PF03621.8 ESS62524.1 - 0.052 12.9 0.7 0.11 11.8 0.1 1.7 2 0 0 2 2 2 0 MbtH-like protein TSC22 PF01166.13 ESS62524.1 - 0.078 12.9 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family Pyridoxal_deC PF00282.14 ESS62526.1 - 7.9e-15 54.1 0.1 1.5e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain MRP-S26 PF14943.1 ESS62527.1 - 0.071 12.6 4.1 0.12 11.9 2.8 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 XRN_N PF03159.13 ESS62528.1 - 2.3e-19 69.7 0.0 1.4e-11 44.2 0.0 2.2 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus TTL PF03133.10 ESS62529.1 - 1.4e-48 165.3 0.0 1.8e-48 164.9 0.0 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESS62529.1 - 0.0012 18.6 0.0 0.0015 18.2 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp domain TTL PF03133.10 ESS62530.1 - 1.3e-59 201.5 0.0 2e-59 200.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESS62530.1 - 0.0005 19.8 0.0 0.00091 19.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.1 ESS62530.1 - 0.08 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Abhydrolase_5 PF12695.2 ESS62532.1 - 1.1e-25 90.0 0.0 1.8e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS62532.1 - 6.6e-18 65.4 0.0 2.3e-17 63.6 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS62532.1 - 8.4e-10 38.2 0.3 1.6e-08 34.0 0.2 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Ank_4 PF13637.1 ESS62532.1 - 6.5e-09 36.0 0.2 4.4e-07 30.2 0.1 3.0 2 1 1 3 3 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESS62532.1 - 1.6e-08 34.4 0.2 1.7e-06 28.0 0.0 3.3 3 1 1 4 4 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESS62532.1 - 1.9e-08 34.5 0.1 9.7e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESS62532.1 - 7.1e-07 28.8 0.2 0.00015 21.6 0.0 3.2 3 0 0 3 3 2 1 Ankyrin repeat Ank PF00023.25 ESS62532.1 - 1.7e-05 24.4 0.1 0.00022 20.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat AXE1 PF05448.7 ESS62532.1 - 3.4e-05 22.4 0.7 0.011 14.2 0.3 2.6 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.13 ESS62532.1 - 0.00021 20.8 0.0 0.041 13.2 0.0 2.2 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.3 ESS62532.1 - 0.00022 20.9 1.2 0.0013 18.5 0.1 2.7 2 1 1 3 3 3 1 Putative lysophospholipase DUF829 PF05705.9 ESS62532.1 - 0.0079 15.9 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) BAAT_C PF08840.6 ESS62532.1 - 0.028 14.1 0.0 0.094 12.4 0.0 1.9 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF249 PF03158.8 ESS62532.1 - 0.045 13.2 0.0 0.096 12.2 0.0 1.5 1 0 0 1 1 1 0 Multigene family 530 protein Abhydrolase_1 PF00561.15 ESS62532.1 - 0.049 13.1 0.1 5.4 6.4 0.1 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ESS62532.1 - 0.063 12.7 0.1 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydro_lipase PF04083.11 ESS62532.1 - 0.071 12.4 0.0 3.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region UPF0227 PF05728.7 ESS62532.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF1378 PF07125.6 ESS62532.1 - 0.31 11.0 3.4 15 5.5 0.1 3.2 4 0 0 4 4 3 0 Protein of unknown function (DUF1378) Mito_carr PF00153.22 ESS62533.1 - 6.5e-63 208.4 3.1 5.4e-20 70.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein NHL PF01436.16 ESS62534.1 - 4.2e-15 54.8 0.6 0.00029 20.6 0.0 5.4 5 0 0 5 5 5 2 NHL repeat SGL PF08450.7 ESS62534.1 - 4.7e-10 39.2 0.0 9.7e-07 28.4 0.0 2.6 1 1 2 3 3 3 3 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.11 ESS62534.1 - 0.00016 21.6 0.0 0.22 11.6 0.0 3.4 2 1 0 2 2 2 2 Strictosidine synthase Creatinase_N PF01321.13 ESS62534.1 - 0.076 13.4 0.0 0.77 10.2 0.0 2.3 1 1 0 2 2 2 0 Creatinase/Prolidase N-terminal domain GSDH PF07995.6 ESS62534.1 - 0.11 11.5 0.0 0.41 9.6 0.0 2.0 3 1 0 3 3 3 0 Glucose / Sorbosone dehydrogenase MYT1 PF08474.6 ESS62535.1 - 0.00091 18.7 0.2 0.0012 18.3 0.1 1.1 1 0 0 1 1 1 1 Myelin transcription factor 1 DSPc PF00782.15 ESS62537.1 - 1.5e-08 34.3 0.0 2.1e-08 33.8 0.0 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS62537.1 - 5e-06 26.0 0.0 6.2e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 ESS62537.1 - 0.12 11.7 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Mid2 PF04478.7 ESS62537.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DSPc PF00782.15 ESS62538.1 - 2.5e-07 30.3 0.0 3.9e-07 29.7 0.0 1.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS62538.1 - 2.2e-06 27.2 0.0 1.2e-05 24.7 0.0 1.8 1 1 1 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 ESS62538.1 - 0.023 14.1 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) DGF-1_5 PF11038.3 ESS62539.1 - 2.5e-165 548.4 17.7 1.4e-164 546.0 12.3 2.4 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS62539.1 - 4.1e-40 136.0 15.7 4.1e-40 136.0 10.9 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS62539.1 - 2.7e-39 132.9 0.6 2.7e-39 132.9 0.4 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2628 PF10947.3 ESS62542.1 - 0.55 10.0 4.0 0.65 9.8 2.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2628) Fun_ATP-synt_8 PF05933.8 ESS62542.1 - 8.1 6.5 10.2 0.74 9.8 1.9 2.2 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) WD40 PF00400.27 ESS62543.1 - 7.1e-65 212.7 36.0 4e-11 42.3 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESS62543.1 - 5e-06 24.9 19.0 0.069 11.2 0.1 5.4 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PB1 PF00564.19 ESS62543.1 - 0.0051 16.4 0.1 0.032 13.8 0.0 2.4 2 0 0 2 2 2 1 PB1 domain ATP-synt_F6 PF05511.6 ESS62543.1 - 0.016 15.0 0.5 0.054 13.4 0.4 1.9 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 FKBP_N PF01346.13 ESS62543.1 - 0.47 10.5 10.4 0.73 9.8 1.9 2.4 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PH PF00169.24 ESS62544.1 - 1.6e-09 37.9 0.0 3e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 PH domain IFT57 PF10498.4 ESS62544.1 - 0.00065 18.5 7.2 0.00065 18.5 5.0 1.6 2 0 0 2 2 2 1 Intra-flagellar transport protein 57 PH_11 PF15413.1 ESS62544.1 - 0.0015 18.7 0.4 0.0099 16.1 0.3 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain Laminin_II PF06009.7 ESS62544.1 - 0.38 10.4 8.7 2.5 7.8 0.1 2.4 1 1 1 2 2 2 0 Laminin Domain II COG2 PF06148.6 ESS62544.1 - 5.9 6.7 9.3 1.2 8.9 0.1 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MRP-L46 PF11788.3 ESS62545.1 - 2.8e-10 40.8 0.2 8.5e-10 39.2 0.0 1.9 2 1 0 2 2 2 1 39S mitochondrial ribosomal protein L46 Gal4_dimer PF03902.8 ESS62546.1 - 0.051 13.5 0.8 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 Gal4-like dimerisation domain PUF PF00806.14 ESS62547.1 - 1.1e-19 68.7 3.9 0.00083 18.7 0.0 5.8 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat SlyX PF04102.7 ESS62548.1 - 0.008 16.5 3.0 0.014 15.7 0.1 2.8 3 1 0 3 3 3 1 SlyX AAA_13 PF13166.1 ESS62548.1 - 0.055 11.9 1.5 0.066 11.6 1.0 1.0 1 0 0 1 1 1 0 AAA domain Paramyx_P_V_C PF03210.8 ESS62548.1 - 0.15 11.8 2.0 0.21 11.4 0.3 1.9 2 1 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal BMFP PF04380.8 ESS62548.1 - 0.34 11.0 4.0 7.4 6.7 0.4 2.7 2 0 0 2 2 2 0 Membrane fusogenic activity Ly49 PF08391.5 ESS62548.1 - 0.52 10.4 2.9 0.8 9.8 0.4 2.3 1 1 2 3 3 3 0 Ly49-like protein, N-terminal region TMF_TATA_bd PF12325.3 ESS62548.1 - 0.53 10.0 8.8 0.29 10.8 3.8 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding PB1 PF00564.19 ESS62549.1 - 0.11 12.1 0.0 6.7 6.4 0.0 2.6 2 0 0 2 2 2 0 PB1 domain CytochromB561_N PF09786.4 ESS62550.1 - 1.2e-07 30.6 0.1 0.00012 20.6 0.0 2.2 1 1 1 2 2 2 2 Cytochrome B561, N terminal Pro_isomerase PF00160.16 ESS62551.1 - 2.4e-49 167.5 1.5 2.7e-49 167.3 1.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HD PF01966.17 ESS62552.1 - 8.4e-15 54.8 0.0 1.9e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 HD domain HDOD PF08668.7 ESS62552.1 - 0.00014 21.1 0.0 0.00025 20.3 0.0 1.4 1 0 0 1 1 1 1 HDOD domain Kinesin PF00225.18 ESS62553.1 - 4.7e-54 183.3 0.0 5.6e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 ESS62553.1 - 0.061 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESS62553.1 - 0.16 11.7 0.7 0.71 9.6 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 Exo_endo_phos_2 PF14529.1 ESS62554.1 - 4.9e-16 58.4 0.0 7.5e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS62554.1 - 0.00042 20.3 0.0 0.00076 19.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.22 ESS62555.1 - 3e-21 75.7 0.0 3.8e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_jaz PF12171.3 ESS62556.1 - 0.27 11.4 7.9 2.2 8.5 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS62556.1 - 0.67 10.4 16.2 2.7 8.5 1.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC5 PF06221.8 ESS62556.1 - 4.1 7.2 8.0 6.1 6.6 0.8 3.0 3 0 0 3 3 3 0 Putative zinc finger motif, C2HC5-type zf-Di19 PF05605.7 ESS62556.1 - 4.9 7.3 11.3 1.4 9.1 4.9 2.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.2 ESS62556.1 - 8.3 6.7 7.8 8.7 6.7 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type BNR_3 PF13859.1 ESS62558.1 - 6.3e-125 416.3 1.7 1.3e-124 415.2 1.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS62558.1 - 2.4e-06 27.2 9.0 2.4e-06 27.2 6.3 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Daxx PF03344.10 ESS62561.1 - 0.05 12.1 33.7 0.062 11.7 23.3 1.2 1 0 0 1 1 1 0 Daxx Family Utp14 PF04615.8 ESS62561.1 - 4.7 5.2 38.8 6.1 4.8 26.9 1.1 1 0 0 1 1 1 0 Utp14 protein Ycf1 PF05758.7 ESS62561.1 - 4.9 4.7 15.3 5.9 4.4 10.6 1.2 1 0 0 1 1 1 0 Ycf1 IncA PF04156.9 ESS62561.1 - 8.8 5.8 10.5 0.11 12.1 1.7 1.9 2 0 0 2 2 2 0 IncA protein FAM163 PF15069.1 ESS62562.1 - 1.6 9.2 11.7 0.47 11.0 1.9 2.4 1 1 1 2 2 2 0 FAM163 family DUF3720 PF12517.3 ESS62566.1 - 4.9e-27 94.4 14.2 4.9e-27 94.4 9.8 4.0 3 2 1 4 4 4 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS62568.1 - 8.1e-132 438.9 5.3 8.1e-132 438.9 3.7 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62568.1 - 1.8e-16 60.7 2.9 2.7e-16 60.1 0.0 2.6 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62568.1 - 4.3e-10 39.2 10.0 1.2e-09 37.9 6.9 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Daxx PF03344.10 ESS62569.1 - 0.75 8.2 12.1 0.96 7.8 8.4 1.1 1 0 0 1 1 1 0 Daxx Family Hid1 PF12722.2 ESS62569.1 - 1.3 6.5 8.9 1.7 6.2 6.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BNR_3 PF13859.1 ESS62572.1 - 1.1e-127 425.3 6.5 1.1e-127 425.3 4.5 2.0 2 1 1 3 3 3 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62572.1 - 2.9e-16 60.0 0.7 8.7e-16 58.5 0.5 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62572.1 - 1.3e-09 37.7 9.1 3e-09 36.5 6.3 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal ASRT PF07100.6 ESS62573.1 - 0.11 12.2 0.0 0.35 10.6 0.0 1.7 1 1 1 2 2 2 0 Anabaena sensory rhodopsin transducer Polysacc_synt_C PF14667.1 ESS62574.1 - 0.0098 15.6 4.0 0.011 15.5 2.8 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis C-terminal domain DUF4271 PF14093.1 ESS62574.1 - 4.2 6.9 11.7 4.9 6.7 8.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) MFS_2 PF13347.1 ESS62574.1 - 4.3 5.6 7.1 1.6 7.0 1.9 1.9 2 0 0 2 2 2 0 MFS/sugar transport protein Peptidase_M8 PF01457.11 ESS62575.1 - 4.3e-94 315.7 0.0 4.8e-94 315.5 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M57 PF12388.3 ESS62575.1 - 0.0095 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.19 ESS62575.1 - 0.049 13.3 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 Matrixin Reprolysin_3 PF13582.1 ESS62575.1 - 0.054 14.0 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 ESS62575.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 ubiquitin PF00240.18 ESS62576.1 - 2.1e-05 23.8 0.0 0.0019 17.5 0.0 2.9 2 1 1 3 3 3 2 Ubiquitin family Lipase_3 PF01764.20 ESS62577.1 - 9.1e-20 70.7 0.0 2.2e-19 69.4 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 ESS62577.1 - 3.4e-07 30.1 0.0 6.5e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 ESS62577.1 - 7.6e-05 22.7 0.1 0.00013 21.9 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS62577.1 - 0.00014 21.5 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESS62577.1 - 0.013 15.0 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 ESS62577.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.3 ESS62577.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PE-PPE PF08237.6 ESS62577.1 - 0.05 13.0 0.0 0.078 12.3 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Lipase PF00151.14 ESS62577.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipase ALMT PF11744.3 ESS62577.1 - 0.39 9.3 2.2 0.59 8.7 1.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SET PF00856.23 ESS62578.1 - 1.8e-05 25.1 0.0 0.0003 21.1 0.0 2.2 1 1 0 1 1 1 1 SET domain Arm PF00514.18 ESS62581.1 - 7.5e-39 130.2 17.4 1.8e-07 30.7 0.0 9.0 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESS62581.1 - 2.1e-26 92.0 13.9 2.5e-07 30.8 0.0 5.0 2 1 3 5 5 5 5 HEAT repeats HEAT PF02985.17 ESS62581.1 - 1.6e-22 77.4 9.4 1.8e-05 24.4 0.0 8.1 8 0 0 8 8 8 6 HEAT repeat HEAT_EZ PF13513.1 ESS62581.1 - 7.3e-18 64.4 20.5 0.00024 21.5 0.1 6.4 5 1 2 7 7 6 6 HEAT-like repeat Adaptin_N PF01602.15 ESS62581.1 - 6.6e-13 47.8 3.5 3.2e-06 25.7 1.1 3.4 2 1 1 3 3 3 2 Adaptin N terminal region Proteasom_PSMB PF10508.4 ESS62581.1 - 2.1e-10 39.4 0.3 1e-07 30.6 0.0 2.8 1 1 2 3 3 3 1 Proteasome non-ATPase 26S subunit DNA_alkylation PF08713.6 ESS62581.1 - 4e-08 33.0 0.0 0.053 13.0 0.0 4.1 2 1 2 4 4 4 3 DNA alkylation repair enzyme Cnd1 PF12717.2 ESS62581.1 - 1.3e-07 31.6 2.1 0.00015 21.6 0.1 4.0 2 1 2 4 4 3 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 ESS62581.1 - 2.4e-05 23.7 0.8 0.05 12.9 0.1 2.8 1 1 1 2 2 2 2 CLASP N terminal V-ATPase_H_C PF11698.3 ESS62581.1 - 0.002 18.0 0.5 0.23 11.3 0.1 3.6 3 1 1 4 4 4 1 V-ATPase subunit H Vac14_Fab1_bd PF12755.2 ESS62581.1 - 0.0024 18.2 0.2 0.063 13.6 0.0 3.2 1 1 2 3 3 3 1 Vacuolar 14 Fab1-binding region Atx10homo_assoc PF09759.4 ESS62581.1 - 0.013 15.2 0.0 4.7 7.0 0.0 2.7 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain DUF3730 PF12530.3 ESS62581.1 - 0.015 15.2 6.3 0.086 12.7 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3730) HEAT_PBS PF03130.11 ESS62581.1 - 0.019 15.4 12.6 2.2 8.9 0.2 5.6 6 0 0 6 6 4 0 PBS lyase HEAT-like repeat DUF3731 PF12531.3 ESS62581.1 - 0.022 14.3 2.2 10 5.5 0.0 3.6 2 1 3 5 5 5 0 DNA-K related protein DUF3361 PF11841.3 ESS62581.1 - 0.028 14.1 3.4 32 4.2 0.0 4.2 1 1 2 4 4 4 0 Domain of unknown function (DUF3361) OHCU_decarbox PF09349.5 ESS62581.1 - 0.05 13.8 1.1 3.2 8.0 0.0 3.3 2 1 1 3 3 3 0 OHCU decarboxylase Xpo1 PF08389.7 ESS62581.1 - 0.092 12.6 0.2 0.39 10.6 0.1 2.2 2 0 0 2 2 1 0 Exportin 1-like protein Spc7 PF08317.6 ESS62582.1 - 0.00011 21.0 2.3 0.00017 20.3 1.6 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Exc PF07825.6 ESS62582.1 - 0.0038 16.9 0.2 0.01 15.6 0.1 1.7 1 0 0 1 1 1 1 Excisionase-like protein ATG16 PF08614.6 ESS62582.1 - 0.0061 16.4 7.4 0.0061 16.4 5.2 2.3 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) HAP1_N PF04849.8 ESS62582.1 - 0.0077 15.2 6.9 0.0098 14.8 3.7 1.7 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Tropomyosin_1 PF12718.2 ESS62582.1 - 0.015 15.1 6.6 0.026 14.3 3.6 2.2 1 1 0 1 1 1 0 Tropomyosin like HAUS4 PF14735.1 ESS62582.1 - 0.023 13.9 1.3 0.046 13.0 0.9 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 CENP-H PF05837.7 ESS62582.1 - 0.026 14.6 3.1 0.026 14.6 2.2 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) IncA PF04156.9 ESS62582.1 - 0.034 13.7 10.6 0.029 13.9 6.6 1.5 1 1 0 1 1 1 0 IncA protein DUF607 PF04678.8 ESS62582.1 - 0.036 13.9 1.5 0.055 13.3 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF607 KIAA1430 PF13879.1 ESS62582.1 - 0.042 14.2 1.4 0.042 14.2 1.0 2.2 3 0 0 3 3 2 0 KIAA1430 homologue GAS PF13851.1 ESS62582.1 - 0.081 12.1 6.7 0.23 10.6 4.0 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Caps_synth_GfcC PF06251.6 ESS62582.1 - 0.11 11.6 1.3 0.19 10.8 0.9 1.4 1 0 0 1 1 1 0 Capsule biosynthesis GfcC TMF_DNA_bd PF12329.3 ESS62582.1 - 0.18 11.6 6.4 0.18 11.6 2.5 2.5 2 1 1 3 3 2 0 TATA element modulatory factor 1 DNA binding DUF4446 PF14584.1 ESS62582.1 - 0.21 11.3 1.6 0.83 9.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF883 PF05957.8 ESS62582.1 - 0.22 11.9 7.5 0.073 13.4 2.7 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) TBPIP PF07106.8 ESS62582.1 - 0.45 10.0 3.9 0.27 10.7 0.8 1.9 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) EABR PF12180.3 ESS62582.1 - 1.2 8.5 5.9 0.31 10.4 1.3 2.2 2 0 0 2 2 2 0 TSG101 and ALIX binding domain of CEP55 Lebercilin PF15619.1 ESS62582.1 - 3.4 7.0 16.5 0.13 11.6 5.4 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.7 ESS62582.1 - 3.7 7.2 10.5 0.21 11.3 2.3 2.5 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) Death PF00531.17 ESS62582.1 - 4.9 7.0 7.6 5.2 6.9 0.9 2.9 3 0 0 3 3 2 0 Death domain bZIP_2 PF07716.10 ESS62582.1 - 8.6 6.2 18.8 1.7 8.5 0.7 3.7 3 0 0 3 3 3 0 Basic region leucine zipper DUF3552 PF12072.3 ESS62583.1 - 0.00062 19.0 10.9 0.00062 19.0 7.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) Tropomyosin PF00261.15 ESS62583.1 - 0.0029 16.7 26.3 0.0035 16.4 3.1 2.3 2 0 0 2 2 2 2 Tropomyosin Osmo_CC PF08946.5 ESS62583.1 - 0.052 13.5 4.1 0.14 12.1 2.8 1.7 1 0 0 1 1 1 0 Osmosensory transporter coiled coil DUF1515 PF07439.6 ESS62583.1 - 0.062 13.1 3.9 0.16 11.8 2.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF1828 PF08861.5 ESS62583.1 - 0.12 12.0 0.9 2.8 7.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF1828 HAUS6_N PF14661.1 ESS62583.1 - 0.35 10.1 18.5 1.1 8.5 3.2 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Borrelia_P83 PF05262.6 ESS62583.1 - 0.73 8.0 9.1 0.96 7.6 6.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Tropomyosin_1 PF12718.2 ESS62583.1 - 1.2 8.9 24.7 3.2 7.6 7.9 2.3 2 0 0 2 2 2 0 Tropomyosin like Sec8_exocyst PF04048.9 ESS62583.1 - 1.6 8.3 6.4 0.26 10.9 1.0 2.1 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain COG2 PF06148.6 ESS62583.1 - 4.6 7.1 9.7 0.69 9.7 3.7 1.9 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cluap1 PF10234.4 ESS62583.1 - 6.3 5.9 15.1 3.2 6.8 8.8 1.6 1 1 0 1 1 1 0 Clusterin-associated protein-1 PUF PF00806.14 ESS62585.1 - 3.4e-25 86.0 0.2 7.1e-06 25.2 0.0 5.3 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat Ndc1_Nup PF09531.5 ESS62585.1 - 0.0025 16.2 0.1 0.0025 16.2 0.1 1.4 2 0 0 2 2 2 1 Nucleoporin protein Ndc1-Nup RNase_PH PF01138.16 ESS62586.1 - 6.8e-06 26.4 0.1 0.024 14.9 0.0 2.2 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 Adaptin_N PF01602.15 ESS62587.1 - 5.5e-71 239.4 8.9 8.6e-71 238.8 6.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 ESS62587.1 - 6.6e-45 152.0 0.5 4e-44 149.4 0.3 2.3 1 1 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 ESS62587.1 - 3.5e-39 133.6 0.0 6.8e-39 132.7 0.0 1.5 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 ESS62587.1 - 5.2e-10 39.4 7.3 6.3e-05 23.1 0.2 5.5 3 2 2 5 5 5 2 HEAT repeats HEAT PF02985.17 ESS62587.1 - 2.4e-05 24.0 1.0 0.2 11.8 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat Ipi1_N PF12333.3 ESS62587.1 - 0.13 12.2 2.0 5.8 6.9 0.0 3.4 3 1 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation Cnd1 PF12717.2 ESS62587.1 - 0.16 11.8 8.9 2.2 8.0 1.4 3.4 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Adap_comp_sub PF00928.16 ESS62591.1 - 6.9e-47 159.7 0.0 9.3e-47 159.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESS62591.1 - 3.1e-05 23.7 0.0 7.1e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Clathrin adaptor complex small chain BTB_2 PF02214.17 ESS62592.1 - 0.017 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain Peptidase_M16 PF00675.15 ESS62593.1 - 4.5e-37 127.0 0.0 9e-37 126.1 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESS62593.1 - 1.7e-06 27.8 0.0 0.0015 18.2 0.0 3.2 3 1 0 3 3 3 2 Peptidase M16 inactive domain BSP_II PF05432.6 ESS62593.1 - 0.01 15.1 7.1 0.016 14.4 4.9 1.2 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Sigma70_ner PF04546.8 ESS62593.1 - 0.13 11.8 5.3 0.26 10.9 3.7 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 ESS62593.1 - 0.24 10.9 5.6 0.42 10.1 3.9 1.3 1 0 0 1 1 1 0 Nucleoplasmin Daxx PF03344.10 ESS62593.1 - 6.9 5.0 9.1 10 4.4 6.3 1.1 1 0 0 1 1 1 0 Daxx Family Autophagy_act_C PF03987.10 ESS62594.1 - 0.079 13.1 1.8 0.24 11.5 1.3 1.9 1 1 0 1 1 1 0 Autophagocytosis associated protein, active-site domain HEAT_2 PF13646.1 ESS62595.1 - 4.1e-10 39.8 2.7 0.00029 21.0 0.0 5.9 5 1 1 6 6 6 2 HEAT repeats HEAT_EZ PF13513.1 ESS62595.1 - 3.9e-07 30.3 4.9 0.038 14.4 0.2 6.3 7 1 1 8 8 8 2 HEAT-like repeat HEAT PF02985.17 ESS62595.1 - 1.1e-06 28.1 6.6 12 6.3 0.0 7.5 7 0 0 7 7 7 3 HEAT repeat TFCD_C PF12612.3 ESS62595.1 - 0.051 12.9 0.5 2.7 7.3 0.1 3.5 2 2 0 3 3 3 0 Tubulin folding cofactor D C terminal Tape_meas_lam_C PF09718.5 ESS62595.1 - 0.099 12.5 0.0 0.53 10.2 0.0 2.3 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) HEAT PF02985.17 ESS62596.1 - 0.0029 17.5 0.9 2.3 8.5 0.0 5.2 5 1 1 6 6 6 1 HEAT repeat CbiG_C PF01890.11 ESS62596.1 - 0.016 15.4 0.0 0.044 14.0 0.0 1.8 1 0 0 1 1 1 0 Cobalamin synthesis G C-terminus TMEM192 PF14802.1 ESS62597.1 - 0.028 13.2 0.1 0.058 12.2 0.1 1.5 1 0 0 1 1 1 0 TMEM192 family Filament PF00038.16 ESS62597.1 - 0.1 12.0 59.3 0.032 13.6 19.8 3.8 1 1 2 3 3 3 0 Intermediate filament protein NPV_P10 PF05531.7 ESS62597.1 - 0.31 11.3 8.4 10 6.4 0.4 4.9 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.7 ESS62597.1 - 1.1 8.9 58.2 1.7 8.4 0.1 5.6 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.7 ESS62597.1 - 4.7 6.2 5.1 1.7 7.7 0.1 2.5 2 2 1 3 3 3 0 Reovirus sigma C capsid protein CPSase_L_D2 PF02786.12 ESS62598.1 - 1.7e-63 213.6 0.0 3.3e-63 212.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESS62598.1 - 5.7e-39 132.6 0.0 1.6e-38 131.1 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESS62598.1 - 7.2e-37 125.6 0.0 1.3e-35 121.5 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 ESS62598.1 - 6.8e-14 52.0 0.9 1.2e-13 51.2 0.1 1.8 2 0 0 2 2 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESS62598.1 - 3.8e-11 42.7 0.0 1.4e-10 40.9 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.17 ESS62598.1 - 5.8e-11 41.8 0.1 1.1e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 ESS62598.1 - 9.3e-10 37.7 0.0 4.8e-08 32.1 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 ESS62598.1 - 1.4e-08 34.2 0.0 2.7e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESS62598.1 - 0.00018 21.0 0.0 0.00059 19.4 0.0 1.8 2 0 0 2 2 2 1 Biotin-lipoyl like RimK PF08443.6 ESS62598.1 - 0.002 17.6 0.0 0.26 10.7 0.0 2.2 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.1 ESS62598.1 - 0.0053 15.9 0.0 0.0092 15.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain HlyD_2 PF12700.2 ESS62598.1 - 0.021 14.0 0.0 0.3 10.1 0.0 2.1 1 1 1 2 2 2 0 HlyD family secretion protein GARS_A PF01071.14 ESS62598.1 - 0.027 14.0 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Toxin_59 PF15537.1 ESS62598.1 - 0.077 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative toxin 59 HlyD PF00529.15 ESS62598.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 HlyD family secretion protein ATPgrasp_ST PF14397.1 ESS62598.1 - 0.17 10.9 0.1 0.44 9.5 0.0 1.6 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Pkinase PF00069.20 ESS62601.1 - 5.5e-64 215.8 0.0 7.6e-64 215.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS62601.1 - 1.2e-42 145.7 0.0 1.6e-42 145.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS62601.1 - 8e-11 41.4 0.0 1.3e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PH PF00169.24 ESS62601.1 - 1.2e-08 35.0 0.0 2.1e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 ESS62601.1 - 5.1e-07 29.8 0.1 1.6e-05 25.0 0.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 ESS62601.1 - 0.00048 20.3 0.5 0.28 11.4 0.0 2.7 2 1 1 3 3 3 2 Pleckstrin homology domain DGF-1_5 PF11038.3 ESS62602.1 - 1.3e-151 503.5 18.5 1.3e-151 503.5 12.8 1.9 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS62602.1 - 1.3e-46 156.3 1.0 2.5e-46 155.4 0.7 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF1129 PF06570.6 ESS62602.1 - 1.9 7.7 4.2 0.76 9.0 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) DUF3568 PF12092.3 ESS62603.1 - 0.57 9.8 3.7 15 5.3 0.0 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3568) Mito_fiss_reg PF05308.6 ESS62604.1 - 2.4 7.4 7.3 4 6.7 5.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator BNR_3 PF13859.1 ESS62606.1 - 6e-59 199.6 0.0 1.2e-58 198.6 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62606.1 - 2.1e-15 57.3 1.6 8.5e-15 55.3 1.1 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62606.1 - 1.7e-09 37.3 4.1 1.7e-09 37.3 2.8 2.9 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62606.1 - 1.2e-06 28.0 1.0 4.2e-05 22.9 0.4 2.7 1 1 1 3 3 3 2 BNR repeat-like domain BNR PF02012.15 ESS62606.1 - 0.01 15.5 9.6 0.58 10.2 0.4 3.9 3 0 0 3 3 3 0 BNR/Asp-box repeat Cuticle_1 PF08140.6 ESS62606.1 - 0.013 15.2 0.4 0.12 12.2 0.0 2.7 3 0 0 3 3 3 0 Crustacean cuticle protein repeat Glycos_transf_2 PF00535.21 ESS62609.1 - 0.0018 17.9 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 MGC-24 PF05283.6 ESS62612.1 - 0.00035 20.4 0.5 0.00084 19.1 0.4 1.6 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24) DNA_pol_viral_C PF00336.13 ESS62614.1 - 0.036 13.3 0.0 0.085 12.1 0.0 1.6 1 1 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RNase_H PF00075.19 ESS62614.1 - 0.13 12.6 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 RNase H Mucin PF01456.12 ESS62615.1 - 0.0017 18.1 10.6 0.003 17.3 7.4 1.5 1 1 0 1 1 1 1 Mucin-like glycoprotein BNR_3 PF13859.1 ESS62619.1 - 7.3e-135 448.9 7.1 7.3e-135 448.9 4.9 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62619.1 - 9.8e-17 61.6 0.1 2.5e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62619.1 - 1.8e-10 40.4 11.5 1.8e-10 40.4 8.0 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Glyco_hydro_32N PF00251.15 ESS62619.1 - 0.033 13.5 0.4 0.72 9.1 0.2 2.4 2 1 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain Peptidase_M8 PF01457.11 ESS62620.1 - 1.9e-13 49.6 7.7 9.8e-12 43.9 5.3 2.0 1 1 0 1 1 1 1 Leishmanolysin DUF1397 PF07165.6 ESS62621.1 - 0.0022 17.2 0.6 0.004 16.3 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1397) DUF4614 PF15391.1 ESS62621.1 - 6 6.5 13.9 15 5.2 6.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4614) BNR_3 PF13859.1 ESS62623.1 - 1.7e-63 214.5 1.8 2e-63 214.3 0.4 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS62623.1 - 8.2e-07 28.7 5.6 8.2e-07 28.7 3.9 2.6 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS62625.1 - 9.7e-28 96.9 0.0 1e-27 96.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS62626.1 - 9.7e-08 31.0 0.1 1.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein Mucin PF01456.12 ESS62628.1 - 3.9e-33 114.2 53.2 2.3e-23 82.5 16.6 2.3 1 1 1 2 2 2 2 Mucin-like glycoprotein DUF4658 PF15555.1 ESS62628.1 - 0.24 11.2 0.1 0.24 11.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) Sec1 PF00995.18 ESS62629.1 - 0.00066 18.4 0.0 0.00072 18.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Daxx PF03344.10 ESS62632.1 - 0.18 10.2 9.4 0.24 9.8 6.5 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 ESS62632.1 - 3.8 5.3 8.6 4.4 5.0 6.0 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_viral_C PF00336.13 ESS62634.1 - 0.024 13.9 0.0 0.059 12.6 0.0 1.8 1 1 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RVT_3 PF13456.1 ESS62634.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like RHSP PF07999.6 ESS62637.1 - 6.4e-80 268.8 0.0 9.6e-80 268.3 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DDE_Tnp_1_6 PF13751.1 ESS62638.1 - 0.78 9.7 5.3 0.26 11.3 0.3 2.4 1 1 1 2 2 2 0 Transposase DDE domain RHSP PF07999.6 ESS62643.1 - 1.1e-97 327.4 0.5 1.5e-97 327.0 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS62643.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain BNR_3 PF13859.1 ESS62644.1 - 1e-55 189.0 3.4 1.3e-55 188.6 2.3 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62644.1 - 8.1e-10 38.4 0.4 3.8e-05 23.1 0.0 1.9 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS62644.1 - 0.00062 19.1 8.2 0.11 12.4 0.1 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF2538 PF10804.3 ESS62644.1 - 0.0075 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2538) Laminin_G_3 PF13385.1 ESS62645.1 - 8.1e-10 39.1 0.1 1.1e-09 38.7 0.1 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DGF-1_5 PF11038.3 ESS62650.1 - 1.3e-161 536.3 17.6 1.3e-161 536.3 12.2 3.3 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS62650.1 - 1.8e-40 137.1 15.3 5.2e-40 135.6 10.6 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS62650.1 - 1.7e-26 91.9 3.2 2.4e-26 91.4 0.6 2.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus RHSP PF07999.6 ESS62651.1 - 3e-34 118.3 0.8 4.9e-34 117.6 0.5 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein IL6Ra-bind PF09240.5 ESS62652.1 - 0.03 14.4 1.2 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding RHSP PF07999.6 ESS62653.1 - 2.8e-79 266.7 0.2 4.7e-79 266.0 0.2 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS62653.1 - 0.007 15.8 2.0 0.65 9.3 0.0 2.6 3 0 0 3 3 3 2 AAA-like domain RHSP PF07999.6 ESS62654.1 - 1.3e-36 126.1 0.0 2e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein ASF1_hist_chap PF04729.8 ESS62654.1 - 0.062 12.9 0.1 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 ASF1 like histone chaperone DUF3676 PF12429.3 ESS62655.1 - 5.8e-106 353.2 41.3 9e-106 352.6 28.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS62655.1 - 4.6e-81 272.2 0.1 1.1e-80 271.0 0.1 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62655.1 - 3e-10 40.5 1.4 3e-10 40.5 1.0 2.6 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62655.1 - 2e-07 30.7 3.4 2e-07 30.7 2.3 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal LEA_3 PF03242.8 ESS62656.1 - 0.0046 17.1 0.4 0.01 16.0 0.2 1.5 1 0 0 1 1 1 1 Late embryogenesis abundant protein DUF1071 PF06378.6 ESS62656.1 - 0.11 11.6 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) GRAM PF02893.15 ESS62657.1 - 7.7e-18 63.7 1.1 2e-08 33.6 0.2 2.7 2 0 0 2 2 2 2 GRAM domain EF-hand_7 PF13499.1 ESS62659.1 - 2.9e-15 56.1 3.2 2.6e-11 43.4 0.2 3.5 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS62659.1 - 7.7e-08 31.6 1.3 0.00082 19.0 0.1 3.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESS62659.1 - 1.7e-07 30.0 0.6 0.0022 17.1 0.0 4.1 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 ESS62659.1 - 9.6e-05 21.5 0.2 0.00058 19.0 0.0 2.5 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.4 ESS62659.1 - 0.01 15.8 0.2 0.9 9.5 0.0 2.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.1 ESS62659.1 - 0.034 13.7 0.3 14 5.3 0.0 3.7 4 0 0 4 4 4 0 EF-hand domain pair Abhydrolase_6 PF12697.2 ESS62660.1 - 8.4e-05 22.5 0.1 0.00014 21.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS62660.1 - 0.0044 16.5 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold RuvA_C PF07499.8 ESS62662.1 - 0.021 14.9 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 RuvA, C-terminal domain SlyX PF04102.7 ESS62663.1 - 4.8 7.6 7.4 19 5.6 0.1 3.2 3 0 0 3 3 3 0 SlyX Striatin PF08232.7 ESS62664.1 - 0.14 12.5 0.0 0.14 12.5 0.0 4.5 3 1 0 4 4 4 0 Striatin family DUF3947 PF13135.1 ESS62664.1 - 3.3 7.9 14.0 0.14 12.3 4.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) DUF1515 PF07439.6 ESS62664.1 - 6.7 6.5 9.2 1.4 8.7 0.4 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) AAA PF00004.24 ESS62665.1 - 3.5e-10 40.1 0.0 9.4e-10 38.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS62665.1 - 7.9e-07 29.2 0.0 1.7e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS62665.1 - 3.1e-06 27.9 0.0 1.1e-05 26.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS62665.1 - 8.4e-06 25.5 0.0 2.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS62665.1 - 2.8e-05 23.7 0.1 7.3e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 ESS62665.1 - 3.9e-05 23.5 0.5 9e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 ESS62665.1 - 7.3e-05 21.6 0.0 0.17 10.5 0.0 2.5 3 0 0 3 3 3 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 ESS62665.1 - 0.00011 22.2 0.0 0.0003 20.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 ESS62665.1 - 0.00011 21.6 0.0 0.0011 18.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESS62665.1 - 0.00014 21.9 0.1 0.0003 20.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESS62665.1 - 0.0003 19.9 0.0 0.00054 19.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF258 PF03193.11 ESS62665.1 - 0.00068 18.8 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 ESS62665.1 - 0.00076 19.7 0.0 0.00076 19.7 0.0 1.8 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.7 ESS62665.1 - 0.0044 16.1 0.1 0.012 14.7 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin ABC_tran PF00005.22 ESS62665.1 - 0.0075 16.5 0.0 0.032 14.5 0.0 2.0 1 1 0 1 1 1 1 ABC transporter IstB_IS21 PF01695.12 ESS62665.1 - 0.014 14.8 0.1 0.037 13.4 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.1 ESS62665.1 - 0.015 14.8 0.1 0.035 13.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ESS62665.1 - 0.032 13.8 0.0 0.079 12.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 ESS62665.1 - 0.042 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 ESS62665.1 - 0.043 13.5 0.0 0.083 12.5 0.0 1.4 1 0 0 1 1 1 0 NTPase Polyoma_lg_T_C PF06431.6 ESS62665.1 - 0.057 12.0 0.0 0.091 11.4 0.0 1.2 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus AAA_14 PF13173.1 ESS62665.1 - 0.081 12.8 0.0 0.2 11.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESS62665.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Fe-ADH_2 PF13685.1 ESS62667.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase ACBP PF00887.14 ESS62668.1 - 2e-29 101.0 0.2 2.2e-29 100.9 0.2 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein BNR_3 PF13859.1 ESS62669.1 - 2.7e-126 420.8 4.8 4.2e-126 420.2 3.3 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62669.1 - 2.5e-13 50.5 2.4 4.8e-13 49.6 0.7 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62669.1 - 6.3e-07 29.1 9.8 1.4e-06 28.0 6.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62669.1 - 0.00033 20.0 0.1 0.0014 17.9 0.0 2.0 2 0 0 2 2 2 1 BNR repeat-like domain DGF-1_5 PF11038.3 ESS62672.1 - 6.6e-161 533.9 18.3 6.6e-161 533.9 12.7 2.8 4 0 0 4 4 4 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS62672.1 - 4.7e-48 161.0 1.8 4.7e-48 161.0 1.3 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS62672.1 - 8.5e-36 122.1 14.8 2.4e-35 120.7 10.2 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 SID-1_RNA_chan PF13965.1 ESS62672.1 - 3.4 5.7 4.6 5.1 5.1 3.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4407 PF14362.1 ESS62676.1 - 0.88 8.4 11.2 1.9 7.3 7.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mem_trans PF03547.13 ESS62676.1 - 2.6 6.2 5.4 2.9 6.1 1.5 2.4 2 0 0 2 2 2 0 Membrane transport protein Med15 PF09606.5 ESS62681.1 - 0.74 7.9 33.5 0.86 7.7 23.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3801 PF12687.2 ESS62681.1 - 7.4 6.0 24.1 9.5 5.7 16.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) DUF4630 PF15443.1 ESS62682.1 - 0.36 10.6 2.9 1.4 8.7 0.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4630) DUF1397 PF07165.6 ESS62683.1 - 0.0011 18.1 0.9 0.0027 16.9 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1397) BNR_3 PF13859.1 ESS62686.1 - 1.3e-97 326.5 3.7 2.5e-97 325.6 2.6 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62686.1 - 6.2e-17 62.2 1.9 1.7e-16 60.8 1.3 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62686.1 - 4.9e-12 45.4 9.9 1e-11 44.4 6.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62687.1 - 4.8e-23 81.7 0.4 8e-23 80.9 0.3 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS62687.1 - 2.2 8.0 7.3 9.7 5.9 5.1 2.1 1 1 0 1 1 1 0 Mucin-like glycoprotein 2TM PF13239.1 ESS62688.1 - 0.18 11.8 3.9 0.33 11.0 2.7 1.5 1 0 0 1 1 1 0 2TM domain DUF3753 PF12575.3 ESS62688.1 - 2.2 8.1 4.2 3.9 7.3 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) RNase_H PF00075.19 ESS62690.1 - 2.8e-08 34.1 0.0 4.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS62690.1 - 0.016 14.6 2.4 0.096 12.0 0.0 2.6 2 0 0 2 2 2 0 DAN domain zf-C2H2 PF00096.21 ESS62690.1 - 0.63 10.5 10.4 11 6.5 2.7 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type RVT_1 PF00078.22 ESS62691.1 - 8.3e-33 113.5 0.0 2.3e-32 112.1 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.18 ESS62691.1 - 0.0005 20.0 0.0 0.00086 19.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Laminin_G_3 PF13385.1 ESS62693.1 - 4.1e-18 66.1 2.4 7.7e-18 65.2 1.7 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62693.1 - 4.9e-12 45.4 13.1 1.2e-11 44.2 9.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62694.1 - 5.4e-102 341.0 4.9 7.7e-102 340.5 3.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62694.1 - 0.001 18.4 0.2 0.0016 17.8 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS62697.1 - 7.7e-126 419.3 3.8 7.7e-126 419.3 2.6 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62697.1 - 2e-20 73.6 1.0 4.7e-20 72.4 0.7 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62697.1 - 1.6e-09 37.4 12.4 3.5e-09 36.3 8.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2909 PF11137.3 ESS62697.1 - 0.085 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) SelP_N PF04592.9 ESS62698.1 - 3.3 7.0 11.3 4 6.7 7.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.17 ESS62698.1 - 4.6 6.1 6.8 5 6.0 4.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Laminin_G_3 PF13385.1 ESS62700.1 - 3.7e-07 30.4 0.0 5e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3005 PF11448.3 ESS62700.1 - 0.03 13.9 0.1 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) PEGA PF08308.6 ESS62700.1 - 0.099 12.4 0.2 2.8 7.7 0.0 2.4 1 1 0 2 2 2 0 PEGA domain DUF3676 PF12429.3 ESS62701.1 - 3.7e-105 350.6 40.0 5e-105 350.2 27.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS62701.1 - 0.04 13.7 0.1 0.082 12.8 0.1 1.5 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Endotoxin_M PF00555.14 ESS62701.1 - 0.58 9.9 9.5 1.7 8.4 1.1 2.9 2 1 1 3 3 3 0 delta endotoxin Calpain_III PF01067.17 ESS62702.1 - 2.5e-10 40.1 0.0 5.5e-09 35.8 0.0 2.5 2 0 0 2 2 2 1 Calpain large subunit, domain III Peptidase_C2 PF00648.16 ESS62702.1 - 1.3e-09 37.5 0.0 2.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease PPO1_DWL PF12142.3 ESS62702.1 - 0.0016 17.9 0.2 0.004 16.6 0.1 1.6 1 0 0 1 1 1 1 Polyphenol oxidase middle domain Peptidase_C2 PF00648.16 ESS62703.1 - 2.4e-25 89.1 0.0 2.9e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C2 PF00648.16 ESS62705.1 - 5.4e-10 38.7 0.0 9e-10 38.0 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease PPO1_DWL PF12142.3 ESS62705.1 - 0.0041 16.5 0.2 0.01 15.3 0.1 1.6 1 0 0 1 1 1 1 Polyphenol oxidase middle domain UPF0154 PF03672.8 ESS62705.1 - 0.084 12.5 2.9 49 3.6 0.0 4.7 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0154) Radial_spoke_3 PF06098.6 ESS62706.1 - 2.9e-115 384.2 27.5 3.3e-115 384.0 19.1 1.0 1 0 0 1 1 1 1 Radial spoke protein 3 Adeno_VII PF03228.9 ESS62706.1 - 0.58 10.7 17.4 0.035 14.6 3.4 2.5 2 0 0 2 2 2 0 Adenoviral core protein VII Pep3_Vps18 PF05131.9 ESS62708.1 - 8.9e-12 44.6 1.3 8.1e-05 22.0 0.0 3.0 2 1 0 2 2 2 2 Pep3/Vps18/deep orange family Clathrin PF00637.15 ESS62708.1 - 5.4e-08 32.5 0.1 6.4e-07 29.0 0.0 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_2 PF10367.4 ESS62708.1 - 0.0053 16.9 0.4 0.025 14.7 0.1 2.3 2 1 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 NRN1 PF15056.1 ESS62708.1 - 0.022 14.7 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 Neuritin protein family Rabaptin PF03528.10 ESS62708.1 - 0.05 13.5 2.9 1.1 9.1 0.2 2.7 3 0 0 3 3 3 0 Rabaptin Plus-3 PF03126.13 ESS62709.1 - 0.0025 17.8 0.0 0.0061 16.5 0.0 1.7 1 0 0 1 1 1 1 Plus-3 domain ABC2_membrane_4 PF12730.2 ESS62711.1 - 0.41 9.7 7.4 0.56 9.3 5.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein RVT_1 PF00078.22 ESS62712.1 - 0.0074 15.6 0.0 0.0098 15.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR_3 PF13859.1 ESS62714.1 - 1e-54 185.7 7.8 1e-54 185.7 2.5 2.2 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62714.1 - 1.2e-14 54.8 0.2 7.5e-14 52.2 0.0 2.3 2 1 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62714.1 - 1.7e-06 27.7 9.5 3.4e-06 26.8 6.6 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62714.1 - 2e-06 27.3 1.4 0.00013 21.4 0.0 2.6 1 1 0 2 2 2 2 BNR repeat-like domain BNR PF02012.15 ESS62714.1 - 2e-05 23.7 2.3 0.21 11.5 0.1 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat SspN PF08177.6 ESS62715.1 - 0.046 13.4 0.5 0.11 12.2 0.4 1.7 1 0 0 1 1 1 0 Small acid-soluble spore protein N family HTH_Tnp_ISL3 PF13542.1 ESS62715.1 - 0.37 10.0 3.9 0.31 10.2 0.5 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 RHSP PF07999.6 ESS62716.1 - 3.2e-47 161.1 0.3 4.7e-47 160.5 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein FcoT PF10862.3 ESS62716.1 - 0.049 13.1 0.0 0.077 12.5 0.0 1.4 1 0 0 1 1 1 0 FcoT-like thioesterase domain DGF-1_5 PF11038.3 ESS62717.1 - 1.5e-160 532.8 20.0 1.5e-160 532.8 13.8 3.0 4 0 0 4 4 4 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS62717.1 - 2.2e-43 146.0 0.7 2.2e-43 146.0 0.5 2.0 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS62717.1 - 1.8e-31 108.3 17.1 2.9e-31 107.6 10.8 2.2 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Sperm_Ag_HE2 PF05324.8 ESS62720.1 - 0.15 12.0 2.1 5.1 7.0 0.0 2.1 2 0 0 2 2 2 0 Sperm antigen HE2 BNR_3 PF13859.1 ESS62721.1 - 9.1e-67 225.3 3.4 1.4e-66 224.6 2.3 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62721.1 - 6e-07 29.8 0.0 3e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESS62721.1 - 0.00012 21.3 4.1 0.16 11.8 0.3 3.5 2 0 0 2 2 2 2 BNR/Asp-box repeat Tau95 PF09734.4 ESS62727.1 - 3.5e-51 174.3 0.0 5.5e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit IQ PF00612.22 ESS62728.1 - 5.8e-30 100.0 187.5 0.00022 20.5 0.1 26.0 27 0 0 27 27 27 18 IQ calmodulin-binding motif TPR_11 PF13414.1 ESS62728.1 - 9.7e-09 34.7 10.7 4.4e-06 26.2 0.1 5.4 4 1 0 5 5 5 2 TPR repeat TPR_12 PF13424.1 ESS62728.1 - 4.2e-08 33.0 1.4 4.2e-08 33.0 1.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS62728.1 - 0.00097 18.9 0.8 0.00097 18.9 0.5 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS62728.1 - 0.008 15.7 7.4 0.97 9.1 0.0 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS62728.1 - 0.58 10.2 12.5 0.67 10.0 0.1 5.9 5 1 0 5 5 5 0 Tetratricopeptide repeat WD40 PF00400.27 ESS62729.1 - 1.5e-26 91.2 25.5 7.9e-09 35.0 1.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat PRP4 PF08799.6 ESS62729.1 - 5.7e-10 38.2 0.1 5.7e-10 38.2 0.1 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like MC1 PF05854.6 ESS62730.1 - 0.042 13.8 0.2 0.042 13.8 0.1 2.7 3 0 0 3 3 3 0 Non-histone chromosomal protein MC1 HMG_box PF00505.14 ESS62731.1 - 0.014 15.6 1.6 0.014 15.6 1.1 7.9 8 0 0 8 8 8 0 HMG (high mobility group) box Spt20 PF12090.3 ESS62732.1 - 0.36 10.1 13.2 3.8 6.8 0.0 2.7 2 1 0 2 2 2 0 Spt20 family Borrelia_P83 PF05262.6 ESS62732.1 - 9.4 4.3 11.7 19 3.3 5.9 2.2 2 0 0 2 2 2 0 Borrelia P83/100 protein PIF1 PF05970.9 ESS62733.1 - 1.1e-33 116.7 0.0 3.7e-31 108.3 0.0 2.3 2 0 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 ESS62733.1 - 1.1e-08 34.9 0.0 3.8e-08 33.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS62733.1 - 4e-07 29.6 2.4 1.4e-06 27.9 1.7 2.0 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 ESS62733.1 - 0.00087 19.3 0.0 0.0021 18.1 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 ESS62733.1 - 0.00092 18.8 0.1 0.21 11.0 0.0 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 ESS62733.1 - 0.0017 17.7 0.3 0.0035 16.7 0.2 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESS62733.1 - 0.0052 16.2 0.2 0.14 11.5 0.1 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein PhoH PF02562.11 ESS62733.1 - 0.017 14.3 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Herpes_Helicase PF02689.9 ESS62733.1 - 0.017 12.8 1.5 0.15 9.7 0.0 2.1 2 0 0 2 2 2 0 Helicase AAA_22 PF13401.1 ESS62733.1 - 0.019 15.1 0.0 0.047 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 ESS62733.1 - 0.029 13.6 0.3 0.043 13.1 0.2 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain TrwB_AAD_bind PF10412.4 ESS62733.1 - 0.032 12.8 0.1 0.048 12.2 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.10 ESS62733.1 - 0.034 13.8 0.2 8.6 6.0 0.1 2.4 2 0 0 2 2 2 0 NTPase AAA_11 PF13086.1 ESS62733.1 - 0.036 13.6 0.3 8.2 5.9 0.2 2.4 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.9 ESS62733.1 - 0.058 13.1 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DEAD PF00270.24 ESS62733.1 - 0.075 12.5 0.1 0.25 10.8 0.0 1.7 1 1 1 2 2 2 0 DEAD/DEAH box helicase NACHT PF05729.7 ESS62733.1 - 0.087 12.4 0.2 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.1 ESS62733.1 - 0.094 12.2 0.1 0.23 11.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2075 PF09848.4 ESS62733.1 - 0.11 11.4 0.7 0.27 10.1 0.3 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_32 PF13654.1 ESS62733.1 - 0.26 9.8 0.0 0.39 9.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain TK PF00265.13 ESS62734.1 - 4.6e-59 198.9 0.0 6.3e-59 198.4 0.0 1.2 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.1 ESS62734.1 - 0.059 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytochrome_C7 PF14522.1 ESS62734.1 - 0.087 12.4 2.2 0.22 11.1 1.6 1.6 1 0 0 1 1 1 0 Cytochrome c7 AAA_13 PF13166.1 ESS62736.1 - 9.3e-05 21.1 47.4 0.0012 17.4 17.7 2.3 2 0 0 2 2 2 2 AAA domain NPV_P10 PF05531.7 ESS62736.1 - 0.64 10.3 18.0 16 5.8 1.2 5.4 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Tropomyosin PF00261.15 ESS62737.1 - 1.3 8.0 30.5 0.064 12.3 4.2 2.0 1 1 1 2 2 2 0 Tropomyosin Dak2 PF02734.12 ESS62737.1 - 2.8 7.5 6.3 10 5.7 4.3 1.8 1 1 1 2 2 2 0 DAK2 domain OmpH PF03938.9 ESS62737.1 - 6.8 6.6 31.1 0.64 9.9 3.4 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) HisKA_3 PF07730.8 ESS62737.1 - 9.1 6.7 16.5 0.73 10.2 3.1 3.5 2 2 1 3 3 3 0 Histidine kinase Lebercilin PF15619.1 ESS62738.1 - 0.005 16.2 12.8 0.005 16.2 8.8 2.7 2 1 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease FlxA PF14282.1 ESS62738.1 - 0.012 15.5 5.2 0.59 10.1 0.1 2.9 3 0 0 3 3 3 0 FlxA-like protein ATG16 PF08614.6 ESS62738.1 - 0.019 14.7 17.3 0.036 13.8 1.2 2.7 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.1 ESS62738.1 - 0.041 12.8 6.8 0.056 12.4 4.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.3 ESS62738.1 - 0.068 12.8 17.4 2.1 8.0 1.3 3.5 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding AAA_13 PF13166.1 ESS62738.1 - 0.077 11.4 5.4 0.16 10.3 3.7 1.4 1 1 0 1 1 1 0 AAA domain FimP PF09766.4 ESS62738.1 - 0.31 10.0 10.2 0.57 9.1 0.1 3.0 3 0 0 3 3 3 0 Fms-interacting protein DUF1192 PF06698.6 ESS62738.1 - 0.46 10.3 4.5 0.17 11.7 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) TPR_MLP1_2 PF07926.7 ESS62738.1 - 0.95 9.2 17.4 0.11 12.2 1.6 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein HAUS-augmin3 PF14932.1 ESS62738.1 - 1.3 8.1 12.1 0.043 13.0 1.7 2.6 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 Phage_GP20 PF06810.6 ESS62738.1 - 1.3 8.4 10.1 2.8 7.3 0.2 3.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 Laminin_II PF06009.7 ESS62738.1 - 1.7 8.4 6.2 2 8.1 0.2 2.6 3 0 0 3 3 3 0 Laminin Domain II DUF641 PF04859.7 ESS62738.1 - 2.5 7.8 11.6 1 9.1 0.4 3.1 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) IFP_35_N PF07334.8 ESS62738.1 - 2.6 8.0 7.4 4.4 7.3 0.5 3.5 2 1 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus IncA PF04156.9 ESS62738.1 - 4.2 6.9 22.2 2.2 7.8 9.0 2.9 2 1 0 2 2 2 0 IncA protein Spc24 PF08286.6 ESS62738.1 - 4.5 6.9 11.8 5.4 6.7 0.5 3.3 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 TBPIP PF07106.8 ESS62738.1 - 5.1 6.6 15.9 1.4 8.4 0.7 3.4 1 1 3 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ORC3_N PF07034.6 ESS62739.1 - 0.028 13.3 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus BNR_3 PF13859.1 ESS62742.1 - 7.9e-126 419.3 1.9 7.9e-126 419.3 1.3 2.4 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62742.1 - 1e-18 68.0 0.5 2.5e-18 66.7 0.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62742.1 - 2.1e-06 27.4 9.2 6.3e-06 25.9 6.4 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2909 PF11137.3 ESS62742.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) AMA-1 PF02430.10 ESS62743.1 - 0.045 12.6 0.0 0.053 12.3 0.0 1.1 1 0 0 1 1 1 0 Apical membrane antigen 1 Daxx PF03344.10 ESS62744.1 - 1.2 7.5 7.3 1.4 7.2 5.0 1.0 1 0 0 1 1 1 0 Daxx Family BNR_3 PF13859.1 ESS62746.1 - 2.1e-132 440.9 2.4 3.9e-132 440.0 1.7 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62746.1 - 3.6e-18 66.3 0.4 8.8e-18 65.0 0.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62746.1 - 7.3e-08 32.1 9.3 1.8e-07 30.9 6.5 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS62748.1 - 1.6e-27 96.0 28.2 1.8e-27 95.8 19.5 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein MGC-24 PF05283.6 ESS62748.1 - 0.032 14.0 15.8 0.031 14.0 10.9 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) TraV PF09676.5 ESS62748.1 - 0.45 11.2 5.2 0.54 10.9 3.6 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) TMEM154 PF15102.1 ESS62748.1 - 0.88 9.2 8.9 0.94 9.1 6.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family Menin PF05053.8 ESS62748.1 - 1 7.4 3.4 0.98 7.5 2.3 1.0 1 0 0 1 1 1 0 Menin DUF3484 PF11983.3 ESS62748.1 - 1.2 9.9 3.8 1.8 9.4 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) Lamp PF01299.12 ESS62748.1 - 8.2 5.4 13.1 9 5.3 9.1 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Synaphin PF05835.7 ESS62750.1 - 0.41 10.7 9.0 0.66 10.1 6.3 1.5 1 1 0 1 1 1 0 Synaphin protein Herpes_env PF01673.13 ESS62750.1 - 5.1 5.5 8.6 5 5.5 6.0 1.0 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Mucin PF01456.12 ESS62753.1 - 6.6e-05 22.7 4.5 6.6e-05 22.7 3.1 4.1 3 2 1 4 4 4 1 Mucin-like glycoprotein DNA_pol_viral_C PF00336.13 ESS62754.1 - 0.066 12.4 0.0 0.19 10.9 0.0 1.8 1 1 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RHSP PF07999.6 ESS62756.1 - 1.5e-79 267.6 0.0 2.2e-79 267.1 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS62756.1 - 0.011 15.8 0.4 8.8 6.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain HMG_CoA_synt_N PF01154.12 ESS62757.1 - 1.1e-11 44.5 0.0 2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.5 ESS62757.1 - 1.5e-08 34.4 0.2 0.00032 20.2 0.0 2.3 2 0 0 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III PF08545.5 ESS62757.1 - 0.01 15.4 0.2 0.021 14.4 0.2 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1726 PF08351.6 ESS62757.1 - 0.069 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) UQ_con PF00179.21 ESS62758.1 - 7.8e-07 28.6 0.0 1.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme GDPD PF03009.12 ESS62759.1 - 2.8e-21 76.1 0.0 4.2e-21 75.6 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2451 PF10474.4 ESS62760.1 - 8e-08 32.3 0.8 1.3e-07 31.6 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) Anticodon_1 PF08264.8 ESS62760.1 - 0.098 12.4 0.1 10 5.8 0.0 2.6 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA DUF2450 PF10475.4 ESS62761.1 - 3.5e-15 55.6 7.2 3.5e-15 55.6 5.0 2.3 3 0 0 3 3 3 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 ESS62761.1 - 0.0057 16.4 0.8 0.03 14.0 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Arc_PepC PF06819.6 ESS62761.1 - 6 6.8 6.9 8.9 6.2 0.0 3.6 4 0 0 4 4 4 0 Archaeal Peptidase A24 C-terminal Domain Aminotran_1_2 PF00155.16 ESS62763.1 - 1.7e-62 211.4 0.0 2e-62 211.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SHMT PF00464.14 ESS62763.1 - 9.4e-07 27.5 0.0 9.3e-06 24.2 0.0 2.4 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 ESS62763.1 - 1.5e-05 24.3 0.1 2.3e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 ESS62763.1 - 8e-05 21.5 0.0 0.00031 19.5 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V HATPase_c_5 PF14501.1 ESS62763.1 - 0.017 14.8 0.1 0.088 12.5 0.0 2.2 3 0 0 3 3 3 0 GHKL domain Cys_Met_Meta_PP PF01053.15 ESS62763.1 - 0.018 13.3 0.0 0.031 12.5 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Torsin PF06309.6 ESS62764.1 - 2.2e-06 27.5 0.0 4.7e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Torsin RuvB_N PF05496.7 ESS62764.1 - 0.00027 20.0 0.0 0.00042 19.4 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 ESS62764.1 - 0.003 17.7 0.0 0.0057 16.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ESS62764.1 - 0.0039 16.8 0.1 0.084 12.5 0.1 2.5 1 1 0 1 1 1 1 NACHT domain AAA_21 PF13304.1 ESS62764.1 - 0.015 15.2 0.4 0.42 10.5 0.0 2.6 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.1 ESS62764.1 - 0.016 15.5 0.0 0.041 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 ESS62764.1 - 0.02 15.2 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.15 ESS62764.1 - 0.021 14.4 0.0 0.33 10.6 0.0 2.3 2 1 0 2 2 2 0 Adenylylsulphate kinase MASE1 PF05231.9 ESS62764.1 - 0.061 12.3 0.1 0.096 11.6 0.1 1.3 1 0 0 1 1 1 0 MASE1 NB-ARC PF00931.17 ESS62764.1 - 0.072 11.9 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.22 ESS62764.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.1 ESS62764.1 - 0.11 13.2 0.0 0.36 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF4131 PF13567.1 ESS62765.1 - 0.044 13.1 3.8 0.061 12.7 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF454 PF04304.8 ESS62765.1 - 0.13 12.2 2.4 0.27 11.2 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF454) Cyt-b5 PF00173.23 ESS62766.1 - 1.4e-10 40.8 0.2 3.5e-08 33.1 0.1 2.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 ESS62766.1 - 1.1e-05 25.0 6.0 1.5e-05 24.6 4.1 1.1 1 0 0 1 1 1 1 Fatty acid desaturase UPF0158 PF03682.8 ESS62766.1 - 0.023 14.3 0.0 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0158) FA_desaturase PF00487.19 ESS62767.1 - 1.5e-06 27.8 6.6 1.5e-06 27.8 4.6 2.8 2 1 1 3 3 3 2 Fatty acid desaturase WD40 PF00400.27 ESS62768.1 - 5.1e-79 257.5 27.5 8.1e-12 44.5 0.2 8.4 8 0 0 8 8 8 8 WD domain, G-beta repeat NLE PF08154.7 ESS62768.1 - 5.1e-15 55.2 0.0 8.7e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.6 ESS62768.1 - 5.3e-06 26.2 0.0 0.039 13.6 0.0 2.8 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 ESS62768.1 - 0.00041 19.9 0.9 12 5.6 0.0 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.3 ESS62768.1 - 0.0011 17.2 4.4 0.74 7.8 0.9 4.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nbas_N PF15492.1 ESS62768.1 - 0.002 17.2 0.1 0.93 8.5 0.0 3.5 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.4 ESS62768.1 - 1 8.7 4.9 18 4.7 0.1 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF1227 PF06777.6 ESS62769.1 - 7.4e-46 155.4 0.4 1.3e-45 154.6 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 ESS62769.1 - 5.9e-40 136.5 0.0 1.6e-39 135.1 0.0 1.8 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 ESS62769.1 - 7.8e-39 133.2 0.0 1.6e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.24 ESS62769.1 - 0.00011 21.7 0.4 0.038 13.4 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESS62769.1 - 0.00088 19.1 0.4 0.0031 17.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESS62769.1 - 0.0024 17.5 0.1 0.0084 15.8 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 ESS62769.1 - 0.0069 16.5 0.4 0.047 13.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain Flavi_DEAD PF07652.9 ESS62769.1 - 0.02 14.6 0.5 0.94 9.2 0.0 2.7 2 0 0 2 2 2 0 Flavivirus DEAD domain AAA_11 PF13086.1 ESS62769.1 - 0.034 13.7 0.0 0.067 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain Cullin PF00888.17 ESS62770.1 - 1.8e-80 271.2 1.3 2.6e-80 270.6 0.9 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESS62770.1 - 9.8e-26 89.3 2.3 2.8e-25 87.9 1.6 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF3658 PF12395.3 ESS62770.1 - 0.045 13.2 0.4 0.5 9.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function Pkinase PF00069.20 ESS62772.1 - 8.4e-62 208.6 0.0 9.9e-62 208.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS62772.1 - 4.7e-39 134.0 0.0 6.1e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS62772.1 - 0.0003 19.8 0.0 0.00081 18.4 0.0 1.7 1 1 0 1 1 1 1 Kinase-like YjcZ PF13990.1 ESS62772.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 YjcZ-like protein DDRGK PF09756.4 ESS62773.1 - 0.0048 16.3 23.5 0.0048 16.3 16.3 2.0 2 0 0 2 2 2 1 DDRGK domain DUF1675 PF07897.6 ESS62773.1 - 0.4 10.5 10.8 0.031 14.1 4.3 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1675) GAGA_bind PF06217.7 ESS62773.1 - 2 8.3 7.6 3.3 7.6 5.3 1.3 1 1 0 1 1 1 0 GAGA binding protein-like family Borrelia_P83 PF05262.6 ESS62773.1 - 6.5 4.9 14.4 12 4.0 10.0 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein RHSP PF07999.6 ESS62774.1 - 3.1e-14 52.4 0.3 4.5e-14 51.8 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Laminin_G_3 PF13385.1 ESS62777.1 - 6e-13 49.3 2.3 8.4e-13 48.8 1.6 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62777.1 - 1.9e-10 40.4 10.0 5e-10 39.0 6.9 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62778.1 - 5.2e-129 429.7 6.8 7e-129 429.3 4.7 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF2828 PF11443.3 ESS62782.1 - 0.12 10.5 6.6 0.17 10.0 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MIP-T3 PF10243.4 ESS62782.1 - 0.21 10.0 19.9 0.25 9.7 13.8 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF2413 PF10310.4 ESS62782.1 - 0.72 8.5 11.0 0.93 8.2 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Mucin PF01456.12 ESS62783.1 - 0.00028 20.6 7.0 0.00028 20.6 4.8 2.2 2 0 0 2 2 2 1 Mucin-like glycoprotein BNR_3 PF13859.1 ESS62784.1 - 7.8e-134 445.5 7.8 1.7e-133 444.4 5.4 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62784.1 - 7.5e-16 58.7 0.5 2.1e-15 57.2 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62784.1 - 1e-06 28.4 10.6 1e-06 28.4 7.4 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF4253 PF14062.1 ESS62785.1 - 0.08 12.5 0.1 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) Urb2 PF10441.4 ESS62785.1 - 0.57 9.7 5.2 0.08 12.5 0.4 1.8 2 0 0 2 2 2 0 Urb2/Npa2 family SelP_N PF04592.9 ESS62785.1 - 5.2 6.3 10.5 1.3 8.3 0.4 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region PhosphMutase PF10143.4 ESS62791.1 - 7.5e-60 201.4 0.0 1.1e-59 200.9 0.0 1.3 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.13 ESS62791.1 - 4.8e-23 81.8 0.0 2e-22 79.7 0.0 1.8 1 1 0 1 1 1 1 Metalloenzyme superfamily AIG2 PF06094.7 ESS62791.1 - 5.5e-22 78.1 0.0 1.2e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 AIG2-like family Haem_bd PF14376.1 ESS62792.1 - 0.05 13.2 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Haem-binding domain Cyclin_N PF00134.18 ESS62794.1 - 0.00033 20.2 0.1 0.00058 19.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain MOZ_SAS PF01853.13 ESS62798.1 - 9.9e-39 132.5 0.9 1.8e-37 128.4 0.3 2.6 2 1 0 2 2 2 1 MOZ/SAS family DNA_topoisoIV PF00521.15 ESS62799.1 - 9.4e-127 423.3 0.0 1.8e-126 422.4 0.0 1.5 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 ESS62799.1 - 3.4e-28 98.0 0.0 9.6e-28 96.5 0.0 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 ESS62799.1 - 4e-10 39.3 0.0 8.5e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.17 ESS62799.1 - 4.4e-09 36.2 0.0 2e-08 34.0 0.0 2.2 2 0 0 2 2 2 1 Toprim domain Myc_N PF01056.13 ESS62799.1 - 0.0041 16.3 6.8 0.0091 15.1 4.7 1.5 1 0 0 1 1 1 1 Myc amino-terminal region DUF1906 PF08924.6 ESS62799.1 - 0.089 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) FlxA PF14282.1 ESS62799.1 - 0.64 9.9 5.6 0.055 13.4 0.2 2.0 2 0 0 2 2 2 0 FlxA-like protein La PF05383.12 ESS62800.1 - 0.0098 15.6 0.1 0.66 9.8 0.0 2.5 1 1 1 2 2 2 2 La domain DUF3802 PF12290.3 ESS62800.1 - 0.058 13.7 1.3 0.16 12.2 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3802) Hexapep PF00132.19 ESS62801.1 - 4.4e-06 25.9 18.4 5.9e-05 22.3 1.9 4.1 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESS62801.1 - 4.5 6.9 27.7 0.071 12.6 1.4 4.6 2 1 4 6 6 6 0 Hexapeptide repeat of succinyl-transferase eIF3_N PF09440.5 ESS62803.1 - 3.5e-24 85.4 0.7 1.3e-23 83.6 0.3 2.1 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 ESS62803.1 - 2.2e-10 40.7 0.1 6.7e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 PCI domain CactinC_cactus PF09732.4 ESS62805.1 - 5.8e-42 142.2 1.4 9.5e-42 141.5 1.0 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DUF3632 PF12311.3 ESS62807.1 - 0.013 15.3 0.2 0.034 13.9 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3632) PEX11 PF05648.9 ESS62808.1 - 1.1e-18 67.2 0.1 1.6e-18 66.8 0.1 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) HiaBD2 PF15403.1 ESS62808.1 - 0.033 14.3 0.1 0.056 13.6 0.1 1.3 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) DUF2207 PF09972.4 ESS62811.1 - 0.073 11.6 1.9 0.08 11.5 1.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) GP4 PF03010.9 ESS62812.1 - 0.16 11.6 1.4 0.18 11.3 0.9 1.1 1 0 0 1 1 1 0 GP4 Metallothio_11 PF02066.10 ESS62813.1 - 0.072 12.9 1.6 0.11 12.3 1.1 1.3 1 0 0 1 1 1 0 Metallothionein family 11 Laminin_G_3 PF13385.1 ESS62814.1 - 6.1e-16 59.0 0.7 1.5e-15 57.7 0.5 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62814.1 - 1.1e-10 41.2 6.4 2.6e-10 39.9 4.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal MRP-S25 PF13741.1 ESS62815.1 - 0.1 12.0 2.0 0.14 11.6 1.4 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 DUF4407 PF14362.1 ESS62817.1 - 0.00032 19.7 1.3 0.00033 19.7 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) IFT57 PF10498.4 ESS62817.1 - 0.043 12.5 1.7 0.057 12.1 1.2 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Phage_integrase PF00589.17 ESS62818.1 - 0.005 16.5 0.0 0.0078 15.8 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family BNR_3 PF13859.1 ESS62820.1 - 1.1e-29 103.5 0.4 1.9e-29 102.7 0.3 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62820.1 - 5.6e-18 65.6 0.4 8.7e-18 65.0 0.3 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS62826.1 - 1.1e-133 445.1 3.1 1.3e-133 444.8 2.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62826.1 - 6.4e-05 22.3 0.2 0.0001 21.7 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain SNURF PF07192.6 ESS62827.1 - 0.52 10.2 3.7 0.7 9.7 0.1 2.1 2 0 0 2 2 2 0 SNURF/RPN4 protein Guanylate_cyc PF00211.15 ESS62828.1 - 0.034 13.5 0.7 0.041 13.2 0.5 1.1 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Nuc_deoxyrib_tr PF05014.10 ESS62829.1 - 2.2e-07 30.7 0.0 3.2e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Lipase_3 PF01764.20 ESS62830.1 - 3.5e-13 49.3 0.0 8.6e-13 48.1 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 ESS62830.1 - 0.028 14.2 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS62830.1 - 0.074 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Metallophos PF00149.23 ESS62831.1 - 1.5e-38 132.2 0.2 2.2e-38 131.6 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 ESS62831.1 - 7e-24 83.6 0.0 1.5e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_11 PF13414.1 ESS62831.1 - 6.2e-23 80.2 5.8 2.4e-16 59.1 1.0 2.3 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESS62831.1 - 9.4e-18 63.0 3.3 6.7e-07 28.6 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS62831.1 - 5.4e-14 50.9 6.1 2.1e-05 24.0 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESS62831.1 - 2.4e-05 23.7 0.5 0.006 16.2 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS62831.1 - 2.8e-05 24.6 3.7 0.0041 17.7 1.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS62831.1 - 3e-05 23.4 0.0 0.015 15.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS62831.1 - 7.9e-05 22.5 6.5 0.0076 16.1 1.3 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat BTAD PF03704.12 ESS62831.1 - 8.4e-05 22.9 0.4 0.00017 21.9 0.3 1.4 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_15 PF13429.1 ESS62831.1 - 0.00023 20.3 0.1 0.27 10.2 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS62831.1 - 0.0004 20.7 0.3 0.05 14.2 0.0 2.9 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS62831.1 - 0.00048 20.1 2.3 0.0041 17.2 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS62831.1 - 0.0013 19.0 0.7 0.92 9.8 0.0 3.0 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS62831.1 - 0.0026 17.5 0.3 0.0077 16.0 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS62831.1 - 0.067 13.3 4.1 0.12 12.5 2.1 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF21 PF01595.15 ESS62832.1 - 7.6e-30 103.5 0.8 1.4e-29 102.7 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESS62832.1 - 0.00021 20.9 1.2 0.51 10.1 0.1 2.9 2 1 0 2 2 2 2 CBS domain DUF21 PF01595.15 ESS62833.1 - 2e-34 118.4 8.6 3.1e-34 117.8 3.5 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF21 cNMP_binding PF00027.24 ESS62833.1 - 0.0015 18.2 0.1 0.0033 17.2 0.1 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CBS PF00571.23 ESS62833.1 - 0.0023 17.6 0.2 2.3 8.0 0.0 3.2 3 0 0 3 3 3 2 CBS domain DUF726 PF05277.7 ESS62834.1 - 1.1e-54 185.6 0.8 1.1e-51 175.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF726) Abhydrolase_5 PF12695.2 ESS62834.1 - 0.06 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family PNK3P PF08645.6 ESS62835.1 - 7.3e-07 28.7 0.0 1.1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Glyco_hydro_31 PF01055.21 ESS62836.1 - 2.9e-145 484.4 4.2 3.5e-145 484.2 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 ESS62836.1 - 1.5e-17 63.1 0.1 8e-17 60.8 0.0 2.3 2 0 0 2 2 2 1 Galactose mutarotase-like 3Beta_HSD PF01073.14 ESS62837.1 - 2.5e-10 39.5 0.0 3.4e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 ESS62837.1 - 6.6e-07 29.5 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 ESS62837.1 - 0.00011 22.5 0.0 0.0002 21.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.20 ESS62837.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 ESS62837.1 - 0.0087 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 ESS62837.1 - 0.017 14.0 0.0 5.9 5.6 0.0 2.8 3 0 0 3 3 3 0 RmlD substrate binding domain DapB_N PF01113.15 ESS62837.1 - 0.054 13.4 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus zf-C2HC_2 PF13913.1 ESS62838.1 - 9.9e-29 98.3 44.4 1e-10 40.9 1.0 7.1 8 0 0 8 8 8 4 zinc-finger of a C2HC-type DZR PF12773.2 ESS62838.1 - 2.3e-23 81.7 51.0 2.5e-11 43.1 7.4 6.7 3 3 2 5 5 5 3 Double zinc ribbon zf-ribbon_3 PF13248.1 ESS62838.1 - 3.3e-19 67.4 47.1 0.00015 20.8 0.7 7.1 7 0 0 7 7 7 5 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESS62838.1 - 1.3e-15 56.3 58.8 1e-05 24.8 3.1 7.7 8 1 1 9 9 7 6 zinc-ribbon domain NOB1_Zn_bind PF08772.6 ESS62838.1 - 0.00023 20.8 35.7 0.0025 17.5 0.5 6.1 5 1 1 6 6 6 3 Nin one binding (NOB1) Zn-ribbon like Sgf11 PF08209.6 ESS62838.1 - 0.00095 18.4 4.3 0.008 15.4 0.3 6.5 8 0 0 8 8 8 3 Sgf11 (transcriptional regulation protein) DUF4287 PF14117.1 ESS62838.1 - 0.0067 16.0 0.2 0.083 12.5 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4287) zf-NADH-PPase PF09297.6 ESS62838.1 - 0.069 12.6 0.3 0.069 12.6 0.2 7.6 8 0 0 8 8 8 0 NADH pyrophosphatase zinc ribbon domain Evr1_Alr PF04777.8 ESS62838.1 - 0.086 12.7 5.1 14 5.7 0.0 4.2 3 1 0 3 3 3 0 Erv1 / Alr family Zn_ribbon_2 PF12674.2 ESS62838.1 - 0.51 10.7 9.1 7.6 6.9 2.5 4.2 3 1 0 3 3 3 0 Putative zinc ribbon domain zf-dskA_traR PF01258.12 ESS62838.1 - 0.81 9.4 32.2 0.13 11.9 1.7 7.6 7 1 1 8 8 8 0 Prokaryotic dksA/traR C4-type zinc finger Rad50_zn_hook PF04423.9 ESS62838.1 - 0.85 9.1 8.5 14 5.2 0.0 4.5 4 0 0 4 4 4 0 Rad50 zinc hook motif OrfB_Zn_ribbon PF07282.6 ESS62838.1 - 1.3 8.6 26.6 0.34 10.5 1.5 6.4 3 1 4 7 7 7 0 Putative transposase DNA-binding domain Nudix_N_2 PF14803.1 ESS62838.1 - 2.9 7.6 48.4 3.4 7.4 0.1 10.3 12 0 0 12 12 11 0 Nudix N-terminal Prok-RING_1 PF14446.1 ESS62838.1 - 4.5 7.0 44.3 1.8 8.3 1.0 8.2 8 1 0 8 8 8 0 Prokaryotic RING finger family 1 MFS_1 PF07690.11 ESS62841.1 - 3e-26 92.0 47.0 3e-26 92.0 32.6 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 ESS62841.1 - 2.8e-10 38.8 30.4 3.5e-05 22.0 0.5 4.2 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family RRM_1 PF00076.17 ESS62842.1 - 0.0018 17.8 0.0 1.2 8.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS62842.1 - 0.026 14.3 0.2 0.094 12.5 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS62842.1 - 0.026 14.4 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) GHMP_kinases_N PF00288.21 ESS62843.1 - 0.81 9.8 4.6 2.1 8.5 3.2 1.7 1 0 0 1 1 1 0 GHMP kinases N terminal domain Voltage_CLC PF00654.15 ESS62848.1 - 7.4e-90 301.5 32.8 5.8e-89 298.5 20.3 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.23 ESS62848.1 - 4e-08 32.9 0.0 0.00047 19.8 0.0 2.6 2 0 0 2 2 2 2 CBS domain FUN14 PF04930.10 ESS62848.1 - 0.015 15.5 0.1 0.16 12.2 0.0 2.8 2 0 0 2 2 2 0 FUN14 family Sipho_Gp157 PF05565.6 ESS62849.1 - 0.047 13.2 4.4 0.051 13.1 3.1 1.0 1 0 0 1 1 1 0 Siphovirus Gp157 U79_P34 PF03064.11 ESS62849.1 - 3.1 7.2 8.5 3.3 7.1 5.9 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 LMWPc PF01451.16 ESS62850.1 - 1e-10 42.0 0.0 1.5e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase DUF1771 PF08590.5 ESS62851.1 - 1.2e-17 63.6 0.3 2.3e-17 62.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.11 ESS62851.1 - 2.4e-12 46.1 0.0 0.001 18.4 0.0 3.7 3 0 0 3 3 3 3 CUE domain Smr PF01713.16 ESS62851.1 - 2.6e-12 46.7 0.0 7.7e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Smr domain zf-CCCH PF00642.19 ESS62851.1 - 0.039 13.6 26.1 1.1 9.0 1.3 5.1 5 0 0 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pro_isomerase PF00160.16 ESS62852.1 - 1.8e-36 125.7 0.0 2.5e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Glyco_hydro_85 PF03644.8 ESS62853.1 - 8.3e-92 307.6 0.0 1.2e-91 307.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Peptidase_C97 PF05903.9 ESS62853.1 - 1.6e-28 99.3 0.0 4.5e-28 97.9 0.0 1.8 2 0 0 2 2 2 1 PPPDE putative peptidase domain PUB PF09409.5 ESS62853.1 - 2.3e-12 46.4 0.0 3.9e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 PUB domain SNF2_N PF00176.18 ESS62854.1 - 1.9e-51 174.6 0.0 4e-51 173.5 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS62854.1 - 2.2e-16 59.4 0.0 6.4e-16 57.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS62854.1 - 1e-05 25.4 0.0 0.079 12.7 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.24 ESS62854.1 - 8.4e-05 22.1 0.0 0.00018 21.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Beta_helix PF13229.1 ESS62855.1 - 2.9e-06 27.1 0.0 4.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 ESS62855.1 - 0.002 17.3 0.0 0.0032 16.6 0.0 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Acetyltransf_1 PF00583.19 ESS62856.1 - 3.3e-17 62.2 0.0 2.6e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESS62856.1 - 9.5e-14 51.3 0.5 2.8e-06 27.3 0.0 3.0 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESS62856.1 - 2.6e-11 43.6 0.0 2.6e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 ESS62856.1 - 0.0002 21.1 0.0 0.94 9.4 0.0 2.6 2 0 0 2 2 2 2 GCN5-related N-acetyl-transferase FR47 PF08445.5 ESS62856.1 - 0.0016 18.1 0.1 0.12 12.1 0.0 2.5 2 1 0 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.1 ESS62856.1 - 0.02 14.7 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PseudoU_synth_2 PF00849.17 ESS62857.1 - 2.5e-24 85.9 0.0 6e-24 84.7 0.0 1.6 2 0 0 2 2 2 1 RNA pseudouridylate synthase DHH PF01368.15 ESS62858.1 - 4.7e-10 39.2 0.0 7.5e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 DHH family WD40 PF00400.27 ESS62859.1 - 5.5e-16 57.7 13.5 5.3e-05 22.9 0.5 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat TPR_6 PF13174.1 ESS62860.1 - 0.0059 16.9 0.1 0.014 15.8 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_5 PF12688.2 ESS62860.1 - 0.043 13.8 0.3 0.094 12.7 0.2 1.5 1 0 0 1 1 1 0 Tetratrico peptide repeat MPC PF03650.8 ESS62863.1 - 1e-13 51.2 0.2 1.2e-13 50.9 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Thioredoxin_8 PF13905.1 ESS62864.1 - 8.8e-07 28.9 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like DUF1935 PF09149.5 ESS62865.1 - 6e-25 87.2 0.0 8.5e-25 86.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) NAP PF00956.13 ESS62866.1 - 1.6e-19 70.0 0.1 4.4e-19 68.5 0.1 1.6 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF1935 PF09149.5 ESS62868.1 - 8.9e-27 93.1 0.0 1.3e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF1880 PF08976.6 ESS62868.1 - 0.29 11.2 1.6 3.7 7.7 1.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1880) Raptor_N PF14538.1 ESS62869.1 - 5.5e-15 55.5 0.0 1.1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain SgrR_N PF12793.2 ESS62869.1 - 0.16 11.9 0.1 0.38 10.7 0.1 1.5 1 0 0 1 1 1 0 Sugar transport-related sRNA regulator N-term DUF1935 PF09149.5 ESS62870.1 - 4.2e-11 42.7 0.0 4.7e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.16 ESS62871.1 - 9.8e-31 106.8 0.0 1.6e-30 106.1 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS62871.1 - 8.2e-21 73.9 0.0 1.4e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.16 ESS62872.1 - 1.7e-51 174.9 0.0 2.4e-51 174.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS62872.1 - 6e-32 109.7 0.1 1.2e-31 108.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.16 ESS62873.1 - 8.6e-45 152.9 0.0 1.2e-44 152.4 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS62873.1 - 3.1e-31 107.4 0.0 5.8e-31 106.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.16 ESS62874.1 - 3.2e-51 174.1 0.0 4.7e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS62874.1 - 1.6e-32 111.5 0.1 3.2e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) SprT-like PF10263.4 ESS62875.1 - 0.0046 16.6 1.2 0.0072 15.9 0.8 1.6 1 1 0 1 1 1 1 SprT-like family Herpes_UL4 PF03277.8 ESS62875.1 - 0.041 13.1 0.1 0.075 12.2 0.0 1.6 1 1 0 1 1 1 0 Herpesvirus UL4 family PhaC_N PF07167.8 ESS62878.1 - 0.16 11.3 0.1 0.28 10.6 0.1 1.3 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus BNR_3 PF13859.1 ESS62883.1 - 1e-131 438.6 4.7 1e-131 438.6 3.2 2.1 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62883.1 - 3.4e-09 37.1 1.5 2.2e-08 34.5 0.2 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS62883.1 - 1.8e-07 30.7 0.1 3.3e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Lin-8 PF03353.10 ESS62885.1 - 0.4 9.9 8.9 0.52 9.5 6.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Hid1 PF12722.2 ESS62885.1 - 3.3 5.2 4.6 4 4.9 3.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.7 ESS62885.1 - 6.5 6.5 14.3 9.3 6.0 9.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 I-set PF07679.11 ESS62886.1 - 0.043 13.6 0.1 0.49 10.2 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin I-set domain Daxx PF03344.10 ESS62888.1 - 0.56 8.6 18.1 0.64 8.4 12.5 1.1 1 0 0 1 1 1 0 Daxx Family Menin PF05053.8 ESS62888.1 - 1.7 6.7 10.9 2.3 6.2 7.6 1.2 1 0 0 1 1 1 0 Menin DUF4375 PF14300.1 ESS62889.1 - 0.12 12.3 0.2 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) MCLC PF05934.6 ESS62889.1 - 4.4 5.4 11.8 5.3 5.2 8.2 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) vMSA PF00695.14 ESS62889.1 - 7.9 5.5 7.5 8.9 5.4 5.2 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Utp14 PF04615.8 ESS62889.1 - 9.2 4.2 15.5 11 3.9 10.8 1.0 1 0 0 1 1 1 0 Utp14 protein Gastrin PF00918.12 ESS62891.1 - 0.077 13.8 0.1 0.13 13.0 0.1 1.3 1 0 0 1 1 1 0 Gastrin/cholecystokinin family BNR_3 PF13859.1 ESS62892.1 - 9.9e-124 412.4 5.9 1.9e-123 411.4 4.1 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62892.1 - 4.3e-16 59.5 1.6 4.3e-16 59.5 1.1 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62892.1 - 1.3e-10 40.9 11.9 3.1e-10 39.7 8.3 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS62892.1 - 0.18 11.7 2.3 15 5.9 0.5 3.5 2 0 0 2 2 2 0 BNR/Asp-box repeat Podoplanin PF05808.6 ESS62894.1 - 0.064 12.8 2.1 0.071 12.6 1.4 1.2 1 0 0 1 1 1 0 Podoplanin SUR7 PF06687.7 ESS62894.1 - 0.065 12.7 1.4 0.07 12.6 0.9 1.1 1 0 0 1 1 1 0 SUR7/PalI family Herpes_gE PF02480.11 ESS62894.1 - 0.15 10.2 1.4 0.18 10.0 1.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF3040 PF11239.3 ESS62894.1 - 0.23 11.5 9.1 0.32 11.0 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) CbiQ PF02361.11 ESS62894.1 - 2.5 7.5 8.2 3 7.3 5.7 1.2 1 0 0 1 1 1 0 Cobalt transport protein CDK5_activator PF03261.10 ESS62896.1 - 0.58 9.4 3.5 14 4.8 3.9 1.9 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein Mucin PF01456.12 ESS62897.1 - 1.9e-34 118.5 50.0 4.2e-33 114.1 34.7 2.4 1 1 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.6 ESS62897.1 - 0.0095 13.9 19.0 0.023 12.7 13.2 1.6 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Sporozoite_P67 PF05642.6 ESS62897.1 - 0.2 9.4 17.9 0.24 9.1 12.4 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dicty_REP PF05086.7 ESS62897.1 - 8 4.0 13.1 11 3.6 9.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF605 PF04652.11 ESS62897.1 - 9.9 5.4 17.3 13 5.0 12.0 1.1 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 ESS62899.1 - 7.5 6.3 9.5 8.7 6.1 6.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tr-sialidase_C PF11052.3 ESS62900.1 - 8.5e-12 44.7 13.1 2.1e-11 43.4 9.1 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal NinF PF05810.7 ESS62901.1 - 0.94 9.3 4.8 1.6 8.5 3.3 1.3 1 0 0 1 1 1 0 NinF protein BNR_3 PF13859.1 ESS62903.1 - 4.9e-129 429.8 3.6 1.4e-128 428.3 2.5 1.8 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62903.1 - 7.7e-17 61.9 2.5 7.8e-17 61.9 0.4 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62903.1 - 6.5e-10 38.7 9.6 1.5e-09 37.5 6.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS62903.1 - 0.0071 15.6 0.1 0.016 14.5 0.1 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Vac7 PF12751.2 ESS62903.1 - 1.2 7.9 9.7 0.013 14.3 1.4 1.5 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 Peptidase_M8 PF01457.11 ESS62905.1 - 1.4e-12 46.8 6.5 4.2e-11 41.8 4.5 2.0 1 1 0 1 1 1 1 Leishmanolysin BNR_3 PF13859.1 ESS62907.1 - 8.4e-131 435.6 7.2 1.5e-130 434.8 5.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62907.1 - 5.1e-18 65.7 0.9 1.4e-17 64.3 0.6 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62907.1 - 7e-08 32.2 9.5 7e-08 32.2 6.6 2.5 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal FAM163 PF15069.1 ESS62908.1 - 2.7 8.5 8.9 0.52 10.8 2.5 2.2 1 1 1 2 2 2 0 FAM163 family BNR_3 PF13859.1 ESS62910.1 - 4.4e-134 446.4 7.0 4.4e-134 446.4 4.9 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62910.1 - 1.2e-18 67.8 0.9 3e-18 66.5 0.7 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62910.1 - 3.2e-07 30.1 8.8 3.2e-07 30.1 6.1 2.5 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Daxx PF03344.10 ESS62913.1 - 0.012 14.1 23.8 0.015 13.8 16.5 1.0 1 0 0 1 1 1 0 Daxx Family Utp14 PF04615.8 ESS62913.1 - 0.25 9.4 26.0 0.31 9.1 18.0 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4658 PF15555.1 ESS62913.1 - 9.4 6.1 7.1 5.4 6.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) PPR_2 PF13041.1 ESS62914.1 - 8e-50 166.6 0.7 3.1e-07 30.2 0.1 13.1 10 4 7 17 17 17 9 PPR repeat family PPR PF01535.15 ESS62914.1 - 6.1e-46 151.2 12.6 0.0012 18.7 0.0 18.1 18 0 0 18 18 18 8 PPR repeat PPR_3 PF13812.1 ESS62914.1 - 1.7e-43 143.2 11.2 0.013 15.6 0.0 17.5 18 1 1 19 19 19 10 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESS62914.1 - 4.2e-20 70.9 5.1 0.02 14.3 0.0 11.6 13 0 0 13 13 13 4 PPR repeat ECSIT PF06239.6 ESS62914.1 - 2.5e-05 23.2 0.0 3.3 6.5 0.0 4.7 4 1 1 5 5 5 2 Evolutionarily conserved signalling intermediate in Toll pathway Clathrin PF00637.15 ESS62914.1 - 0.059 12.9 2.6 16 5.0 0.0 5.4 4 2 2 6 6 6 0 Region in Clathrin and VPS NACHT PF05729.7 ESS62914.1 - 0.078 12.6 0.2 0.35 10.5 0.0 2.2 3 0 0 3 3 3 0 NACHT domain SPOB_a PF14689.1 ESS62914.1 - 0.1 12.1 1.1 27 4.4 0.0 5.1 5 0 0 5 5 5 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_7 PF13176.1 ESS62914.1 - 0.98 9.3 5.3 72 3.5 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF948 PF06103.6 ESS62915.1 - 1.9e-05 24.3 0.2 4.8e-05 23.1 0.2 1.7 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) DUF812 PF05667.6 ESS62915.1 - 0.0031 16.0 1.9 0.0031 16.0 1.3 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF812) Cast PF10174.4 ESS62915.1 - 0.0093 14.0 7.1 0.013 13.5 4.9 1.3 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Syntaxin-6_N PF09177.6 ESS62915.1 - 0.029 14.7 2.4 0.041 14.2 0.3 2.4 3 0 0 3 3 3 0 Syntaxin 6, N-terminal NYD-SP28_assoc PF14775.1 ESS62915.1 - 0.063 12.9 2.9 0.74 9.5 0.1 3.1 3 0 0 3 3 3 0 Sperm tail C-terminal domain CENP-F_leu_zip PF10473.4 ESS62915.1 - 0.091 12.6 8.6 0.45 10.3 3.8 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lzipper-MIP1 PF14389.1 ESS62915.1 - 0.11 12.5 5.5 2.2 8.4 0.1 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 RasGAP_C PF03836.10 ESS62915.1 - 0.32 10.6 2.3 1.6 8.4 1.6 2.0 1 1 0 1 1 1 0 RasGAP C-terminus APG6 PF04111.7 ESS62915.1 - 3.8 6.4 9.3 0.89 8.5 2.9 2.1 1 1 0 2 2 2 0 Autophagy protein Apg6 Gar1 PF04410.9 ESS62916.1 - 1.2e-27 96.2 0.0 4.5e-27 94.3 0.0 1.8 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region FA_desaturase PF00487.19 ESS62917.1 - 1.6e-26 93.2 30.5 1.6e-26 93.2 21.2 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Glycos_transf_1 PF00534.15 ESS62918.1 - 4.3e-12 45.7 0.0 1.8e-11 43.7 0.0 2.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESS62918.1 - 6.2e-07 29.5 0.0 4.6e-06 26.8 0.0 2.3 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESS62918.1 - 2.7e-06 27.5 0.0 7.2e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 DUF1677 PF07911.8 ESS62918.1 - 0.0014 18.7 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1677) Glycogen_syn PF05693.8 ESS62918.1 - 0.0077 14.5 0.0 0.011 13.9 0.0 1.1 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.1 ESS62918.1 - 0.011 15.5 1.3 0.017 14.8 0.2 1.9 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 ESS62918.1 - 0.025 14.6 0.4 0.15 12.2 0.0 2.6 3 0 0 3 3 3 0 Glycosyl transferase 4-like domain Sec61_beta PF03911.11 ESS62919.1 - 0.96 9.2 4.8 1.3 8.8 2.9 1.6 1 1 0 1 1 1 0 Sec61beta family AAA_2 PF07724.9 ESS62920.1 - 7.2e-52 175.7 0.0 2.2e-49 167.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESS62920.1 - 1.1e-24 87.0 0.0 4.2e-14 52.8 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 ESS62920.1 - 5.4e-21 74.3 0.1 2.5e-20 72.1 0.0 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 ESS62920.1 - 2.7e-17 62.7 0.0 2.9e-11 43.2 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS62920.1 - 1e-12 48.4 2.5 0.00035 20.5 0.0 4.7 2 2 1 5 5 5 3 AAA ATPase domain AAA_22 PF13401.1 ESS62920.1 - 1.5e-11 44.5 1.1 0.00016 21.7 0.0 4.8 3 2 1 4 4 4 2 AAA domain AAA_17 PF13207.1 ESS62920.1 - 4.5e-08 33.9 4.7 0.0014 19.4 0.0 4.0 2 1 1 3 3 2 1 AAA domain AAA_18 PF13238.1 ESS62920.1 - 2e-06 28.1 1.7 0.038 14.2 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.1 ESS62920.1 - 1.1e-05 25.3 0.0 0.16 11.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 ESS62920.1 - 2.9e-05 23.2 0.3 0.046 12.7 0.0 3.2 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus ResIII PF04851.10 ESS62920.1 - 6.2e-05 22.8 0.5 0.56 10.0 0.0 4.1 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 ESS62920.1 - 6.9e-05 22.9 0.0 0.41 10.8 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_25 PF13481.1 ESS62920.1 - 7.9e-05 22.1 0.0 0.7 9.2 0.0 3.3 2 1 1 3 3 3 2 AAA domain Sigma54_activat PF00158.21 ESS62920.1 - 8.1e-05 22.1 0.0 0.041 13.3 0.0 3.0 2 1 0 2 2 2 1 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.1 ESS62920.1 - 0.0001 22.0 0.0 0.0031 17.1 0.0 3.1 3 1 0 3 3 2 1 DNA polymerase III, delta subunit AAA_3 PF07726.6 ESS62920.1 - 0.00013 21.5 0.0 0.38 10.3 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 ESS62920.1 - 0.00013 21.4 0.0 0.07 12.5 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 ESS62920.1 - 0.00042 19.4 1.0 0.2 10.6 0.0 3.9 4 1 0 4 4 3 1 Zeta toxin Mg_chelatase PF01078.16 ESS62920.1 - 0.00078 18.6 0.0 2.3 7.3 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI NACHT PF05729.7 ESS62920.1 - 0.001 18.7 0.0 0.037 13.6 0.0 3.0 2 0 0 2 2 2 1 NACHT domain AAA_19 PF13245.1 ESS62920.1 - 0.0013 18.3 0.0 0.15 11.7 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 ESS62920.1 - 0.0017 18.2 0.5 2.7 7.8 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.1 ESS62920.1 - 0.0019 18.1 0.7 1.7 8.5 0.0 3.7 3 1 0 3 3 3 1 AAA domain MobB PF03205.9 ESS62920.1 - 0.0026 17.4 0.1 0.29 10.8 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.24 ESS62920.1 - 0.0031 17.0 0.1 9.3 5.7 0.0 3.6 3 0 0 3 3 3 0 DEAD/DEAH box helicase Arch_ATPase PF01637.13 ESS62920.1 - 0.0044 16.7 8.8 4 7.0 0.1 5.1 3 2 1 4 4 4 0 Archaeal ATPase DUF258 PF03193.11 ESS62920.1 - 0.0045 16.1 0.0 1.7 7.8 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 NTPase_1 PF03266.10 ESS62920.1 - 0.0082 15.8 0.1 2.9 7.5 0.0 3.0 3 0 0 3 3 2 1 NTPase T2SE PF00437.15 ESS62920.1 - 0.009 14.9 0.5 0.077 11.8 0.0 2.9 4 0 0 4 4 2 1 Type II/IV secretion system protein DUF815 PF05673.8 ESS62920.1 - 0.014 14.3 0.1 0.26 10.1 0.0 2.9 4 0 0 4 4 3 0 Protein of unknown function (DUF815) SRP54 PF00448.17 ESS62920.1 - 0.015 14.7 0.0 0.62 9.4 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain His_kinase PF06580.8 ESS62920.1 - 0.019 14.8 0.6 1.7 8.6 0.1 2.8 2 0 0 2 2 2 0 Histidine kinase AAA_24 PF13479.1 ESS62920.1 - 0.019 14.5 0.0 2.1 7.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 ESS62920.1 - 0.02 15.3 0.0 0.3 11.5 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 ESS62920.1 - 0.026 14.0 0.0 4.9 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Torsin PF06309.6 ESS62920.1 - 0.032 14.1 0.0 0.091 12.6 0.0 1.7 2 0 0 2 2 1 0 Torsin V_ATPase_I PF01496.14 ESS62920.1 - 0.034 12.0 3.7 0.051 11.4 2.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ABC_tran PF00005.22 ESS62920.1 - 0.034 14.4 0.0 15 5.8 0.0 3.2 3 1 0 3 3 3 0 ABC transporter Ribosomal_S7 PF00177.16 ESS62920.1 - 0.043 13.4 0.0 0.15 11.6 0.0 1.9 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e UPF0079 PF02367.12 ESS62920.1 - 0.049 13.2 0.0 13 5.3 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ATP_bind_1 PF03029.12 ESS62920.1 - 0.07 12.6 0.0 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IncA PF04156.9 ESS62920.1 - 0.27 10.8 8.5 0.5 9.9 5.9 1.4 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 ESS62920.1 - 0.95 8.4 5.4 1.6 7.6 3.8 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4404 PF14357.1 ESS62920.1 - 2.4 8.6 6.7 2.2 8.7 0.0 3.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4404) AAA_23 PF13476.1 ESS62920.1 - 6.9 6.9 10.5 74 3.5 0.0 3.4 2 1 0 2 2 2 0 AAA domain TMF_DNA_bd PF12329.3 ESS62921.1 - 0.00072 19.3 1.9 0.00072 19.3 1.3 10.0 8 3 3 11 11 11 3 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESS62921.1 - 0.0033 16.8 2.3 0.0033 16.8 1.6 11.0 9 2 4 13 13 13 4 Septum formation initiator Reo_sigmaC PF04582.7 ESS62921.1 - 7.4 5.6 17.8 10 5.2 0.1 4.8 4 2 2 6 6 6 0 Reovirus sigma C capsid protein Seryl_tRNA_N PF02403.17 ESS62922.1 - 0.12 12.3 1.5 0.67 9.9 0.5 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.4 ESS62922.1 - 0.74 9.6 11.1 0.39 10.5 3.6 2.8 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HTH_9 PF08221.6 ESS62923.1 - 0.12 12.2 0.1 7.8 6.4 0.0 3.5 4 0 0 4 4 4 0 RNA polymerase III subunit RPC82 helix-turn-helix domain TrmB PF01978.14 ESS62923.1 - 0.15 11.7 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.5 ESS62923.1 - 0.92 9.1 6.6 5.5 6.6 0.5 4.0 4 0 0 4 4 4 0 IclR helix-turn-helix domain Mito_carr PF00153.22 ESS62924.1 - 1.2e-33 114.6 3.1 7.4e-16 57.6 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Nop14 PF04147.7 ESS62925.1 - 1.7e-40 138.7 30.0 1.6e-25 89.2 0.1 2.6 1 1 1 2 2 2 2 Nop14-like family UAA PF08449.6 ESS62927.1 - 1.3e-38 132.6 23.4 5.7e-27 94.4 6.6 2.2 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.15 ESS62927.1 - 5.5e-06 26.4 7.4 5.5e-06 26.4 5.1 3.7 3 1 0 3 3 3 1 EamA-like transporter family DUF1673 PF07895.6 ESS62927.1 - 0.45 10.0 15.3 0.074 12.5 0.8 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1673) UPF0546 PF10639.4 ESS62927.1 - 0.61 9.9 7.0 0.59 9.9 0.8 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 TPT PF03151.11 ESS62927.1 - 5.2 6.6 27.9 0.012 15.2 7.4 3.5 2 2 1 3 3 3 0 Triose-phosphate Transporter family TPR_11 PF13414.1 ESS62929.1 - 1.3e-16 60.0 6.9 6.5e-09 35.3 1.9 3.0 2 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESS62929.1 - 2.1e-12 46.0 3.6 1.1e-07 31.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESS62929.1 - 2.3e-08 33.3 12.9 1.8e-05 24.2 0.1 4.2 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS62929.1 - 2.8e-05 23.5 4.0 0.0018 17.8 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS62929.1 - 0.0064 16.1 10.4 0.087 12.6 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.13 ESS62929.1 - 0.021 14.6 0.1 0.021 14.6 0.1 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.1 ESS62929.1 - 0.025 15.2 15.3 0.028 15.0 1.5 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS62929.1 - 0.025 14.4 2.0 0.046 13.6 0.1 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 ESS62929.1 - 0.033 14.0 2.3 0.13 12.1 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS62929.1 - 0.13 12.2 13.1 0.55 10.2 0.1 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS62929.1 - 0.13 12.6 6.0 0.98 9.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS62929.1 - 1.4 9.7 0.0 1.4 9.7 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS62929.1 - 1.8 8.6 12.4 5.9 6.9 0.8 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS62929.1 - 2.3 8.8 10.6 0.5 10.9 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESS62929.1 - 6.8 6.6 9.5 0.31 10.9 0.3 3.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Shisa PF13908.1 ESS62934.1 - 0.0071 16.5 0.9 0.031 14.4 0.0 2.2 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator DUF1191 PF06697.7 ESS62934.1 - 0.011 14.5 0.0 0.034 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1191) DUF2207 PF09972.4 ESS62934.1 - 0.038 12.5 0.0 0.061 11.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Herpes_gE PF02480.11 ESS62934.1 - 0.042 12.1 0.0 0.076 11.2 0.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TMEM154 PF15102.1 ESS62934.1 - 0.058 13.1 0.6 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family TRP PF06011.7 ESS62934.1 - 0.12 10.9 0.0 0.22 10.0 0.0 1.3 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel GP41 PF00517.12 ESS62934.1 - 0.23 10.9 0.1 0.37 10.3 0.0 1.2 1 0 0 1 1 1 0 Retroviral envelope protein Vpu PF00558.14 ESS62934.1 - 5.4 6.6 7.8 1.5 8.4 2.3 2.2 3 0 0 3 3 3 0 Vpu protein DUF4138 PF13595.1 ESS62936.1 - 9.1 5.1 0.0 18 4.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) Pkinase PF00069.20 ESS62937.1 - 4.2e-65 219.4 0.0 5.1e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS62937.1 - 1.6e-29 102.7 0.0 9.8e-29 100.1 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS62937.1 - 0.0013 17.7 0.0 0.0026 16.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESS62937.1 - 0.0053 15.8 0.0 0.0084 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS62937.1 - 0.021 14.5 0.1 0.061 13.0 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family UvrD_C_2 PF13538.1 ESS62938.1 - 0.00011 22.2 0.1 0.00021 21.3 0.1 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 ESS62938.1 - 0.00049 17.9 0.0 0.00066 17.5 0.0 1.1 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 ESS62938.1 - 0.03 13.8 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PIF1 PF05970.9 ESS62939.1 - 2.2e-38 132.1 0.0 1.3e-37 129.6 0.0 2.0 2 0 0 2 2 2 1 PIF1-like helicase AAA_30 PF13604.1 ESS62939.1 - 5.2e-17 62.0 0.0 1.8e-16 60.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS62939.1 - 5.1e-09 36.3 0.0 1.2e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS62939.1 - 1.2e-07 31.3 0.6 1.2e-07 31.3 0.4 2.8 3 0 0 3 3 3 1 Part of AAA domain AAA_11 PF13086.1 ESS62939.1 - 1.3e-05 24.9 5.1 0.0022 17.6 0.0 3.6 2 1 1 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.4 ESS62939.1 - 0.00011 20.9 0.2 0.00024 19.8 0.1 1.5 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.1 ESS62939.1 - 0.00066 19.7 0.1 0.0024 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain DUF2075 PF09848.4 ESS62939.1 - 0.001 18.1 0.1 0.001 18.1 0.1 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.24 ESS62939.1 - 0.0027 17.1 0.1 0.23 10.9 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_RecD PF05127.9 ESS62939.1 - 0.0028 17.2 2.9 0.0035 16.9 0.1 2.4 2 1 0 2 2 2 1 Helicase KaiC PF06745.8 ESS62939.1 - 0.0037 16.4 0.1 0.011 14.8 0.0 1.8 2 0 0 2 2 2 1 KaiC UvrD-helicase PF00580.16 ESS62939.1 - 0.0063 15.8 0.1 0.0063 15.8 0.0 2.4 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_5 PF07728.9 ESS62939.1 - 0.0065 16.1 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 ESS62939.1 - 0.0073 15.8 2.8 0.031 13.7 0.1 3.2 3 1 0 3 3 2 1 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 ESS62939.1 - 0.0085 15.8 1.2 0.028 14.1 0.0 2.1 2 0 0 2 2 2 1 Archaeal ATPase AAA PF00004.24 ESS62939.1 - 0.0097 16.1 0.0 0.029 14.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Herpes_Helicase PF02689.9 ESS62939.1 - 0.011 13.5 0.0 0.019 12.7 0.0 1.3 1 0 0 1 1 1 0 Helicase MobB PF03205.9 ESS62939.1 - 0.012 15.2 1.2 0.043 13.5 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 ESS62939.1 - 0.013 14.8 0.0 0.077 12.4 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.21 ESS62939.1 - 0.035 13.5 0.6 0.29 10.5 0.0 2.6 4 0 0 4 4 4 0 Sigma-54 interaction domain Torsin PF06309.6 ESS62939.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Torsin AAA_17 PF13207.1 ESS62939.1 - 0.35 11.7 3.0 20 5.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain Isochorismatase PF00857.15 ESS62940.1 - 1.2e-12 48.1 0.2 2.3e-12 47.2 0.2 1.4 1 1 0 1 1 1 1 Isochorismatase family Isochorismatase PF00857.15 ESS62941.1 - 3.6e-07 30.2 0.0 4.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family BCS1_N PF08740.6 ESS62942.1 - 2.9e-42 144.4 6.0 4.5e-42 143.7 4.2 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 ESS62942.1 - 1.2e-18 67.5 0.0 3.5e-18 66.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ESS62942.1 - 0.00068 19.3 0.4 0.35 10.5 0.0 2.8 2 1 1 3 3 3 2 NACHT domain AAA_17 PF13207.1 ESS62942.1 - 0.0015 19.3 0.0 0.0039 18.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESS62942.1 - 0.0016 18.6 0.1 0.048 13.8 0.0 2.9 3 0 0 3 3 3 1 RNA helicase AAA_5 PF07728.9 ESS62942.1 - 0.0042 16.8 0.0 0.021 14.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 ESS62942.1 - 0.0046 17.2 0.1 0.091 13.0 0.0 2.6 3 0 0 3 3 3 1 ABC transporter DUF815 PF05673.8 ESS62942.1 - 0.0053 15.7 0.0 0.014 14.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_16 PF13191.1 ESS62942.1 - 0.0056 16.6 2.7 0.037 14.0 1.5 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 ESS62942.1 - 0.0094 15.6 0.1 0.47 10.2 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 ESS62942.1 - 0.0096 15.8 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain HXXSHH PF07586.6 ESS62942.1 - 0.018 13.9 1.0 0.036 13.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) RuvB_N PF05496.7 ESS62942.1 - 0.022 13.8 0.0 0.06 12.3 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Rad17 PF03215.10 ESS62942.1 - 0.032 12.9 0.2 0.21 10.2 0.0 2.3 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein AAA_25 PF13481.1 ESS62942.1 - 0.037 13.4 0.0 0.14 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESS62942.1 - 0.053 13.6 0.0 0.19 11.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF885 PF05960.6 ESS62942.1 - 0.084 12.0 0.1 0.18 10.9 0.0 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF885) ABC_tran_2 PF12848.2 ESS62942.1 - 0.11 12.3 0.3 0.23 11.3 0.2 1.5 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.1 ESS62942.1 - 0.11 12.0 0.0 0.28 10.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AKAP7_NLS PF10469.4 ESS62944.1 - 2.2e-21 76.5 0.0 2.8e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 ESS62944.1 - 2.5e-05 24.0 0.0 3.8e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Mucin PF01456.12 ESS62945.1 - 5.2e-40 136.5 65.9 4.5e-28 97.8 20.9 2.6 2 1 0 2 2 2 2 Mucin-like glycoprotein DUF605 PF04652.11 ESS62945.1 - 1.6 8.0 22.1 2.4 7.4 15.3 1.3 1 0 0 1 1 1 0 Vta1 like BNR_3 PF13859.1 ESS62952.1 - 1.3e-63 214.9 1.2 2.6e-63 213.9 0.2 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62952.1 - 2.5e-18 66.8 0.0 5.2e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62952.1 - 2.1e-08 33.8 12.6 4.9e-08 32.7 8.7 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS62953.1 - 1.4e-59 201.7 3.9 1.8e-59 201.3 2.7 1.1 1 0 0 1 1 1 1 BNR repeat-like domain LMBR1 PF04791.11 ESS62954.1 - 0.0019 16.8 5.3 0.0021 16.7 3.7 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein Fer4_8 PF13183.1 ESS62954.1 - 0.023 14.6 1.0 0.032 14.2 0.7 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.1 ESS62954.1 - 0.073 13.4 0.7 0.1 12.9 0.5 1.2 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_16 PF13484.1 ESS62954.1 - 0.092 13.5 0.5 0.12 13.1 0.3 1.3 1 0 0 1 1 1 0 4Fe-4S double cluster binding domain zf-DHHC PF01529.15 ESS62958.1 - 0.028 13.8 0.1 0.028 13.8 0.1 2.8 2 1 0 2 2 2 0 DHHC palmitoyltransferase FLO_LFY PF01698.11 ESS62960.1 - 0.0019 17.1 0.5 0.0026 16.6 0.3 1.1 1 0 0 1 1 1 1 Floricaula / Leafy protein DUF4094 PF13334.1 ESS62960.1 - 0.031 14.6 0.5 0.075 13.4 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Kei1 PF08552.6 ESS62960.1 - 0.15 11.6 1.3 0.2 11.3 0.9 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Ctr PF04145.10 ESS62960.1 - 0.76 9.8 5.7 0.36 10.8 2.2 1.7 1 1 1 2 2 2 0 Ctr copper transporter family UPF0542 PF15086.1 ESS62960.1 - 5.2 6.8 10.2 0.88 9.3 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 BNR_3 PF13859.1 ESS62961.1 - 6.5e-134 445.8 7.1 1.5e-133 444.6 4.7 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62961.1 - 2.9e-16 60.0 0.4 2.9e-16 60.0 0.3 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62961.1 - 1.5e-06 27.9 10.8 3.8e-06 26.6 7.5 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Amastin PF07344.6 ESS62965.1 - 1.9e-42 144.4 3.4 2.5e-42 144.1 2.3 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein Amastin PF07344.6 ESS62966.1 - 1.7e-32 112.1 9.8 2.5e-32 111.6 6.8 1.2 1 0 0 1 1 1 1 Amastin surface glycoprotein 2TM PF13239.1 ESS62966.1 - 0.4 10.7 0.1 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 2TM domain Thiol-ester_cl PF10569.4 ESS62966.1 - 1.1 8.4 4.3 0.26 10.5 0.5 1.8 2 0 0 2 2 2 0 Alpha-macro-globulin thiol-ester bond-forming region CD20 PF04103.10 ESS62966.1 - 2.2 8.2 11.3 0.12 12.2 0.6 2.5 1 1 0 2 2 2 0 CD20-like family 3Beta_HSD PF01073.14 ESS62968.1 - 2.7e-41 141.1 0.0 3.5e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ESS62968.1 - 6.7e-29 100.9 0.0 8.9e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESS62968.1 - 6.2e-17 62.1 0.0 8.7e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 ESS62968.1 - 7.4e-15 54.5 0.1 3.2e-12 45.8 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 ESS62968.1 - 3.6e-11 42.4 0.0 2.6e-10 39.6 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESS62968.1 - 2.5e-09 36.4 0.0 4.3e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 ESS62968.1 - 4.7e-07 29.2 0.0 7.5e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 ESS62968.1 - 1.1e-06 28.6 0.1 2.9e-06 27.2 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS62968.1 - 4e-05 23.3 0.1 0.0003 20.5 0.1 2.1 2 0 0 2 2 2 1 KR domain Saccharop_dh PF03435.13 ESS62968.1 - 0.024 13.5 0.0 0.038 12.9 0.0 1.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase Peptidase_S9 PF00326.16 ESS62969.1 - 4e-35 120.9 0.0 6.9e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.10 ESS62969.1 - 1.5e-22 79.8 0.0 2.6e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain TPR_11 PF13414.1 ESS62970.1 - 3.3e-06 26.6 1.6 1.9e-05 24.2 0.5 2.5 1 1 1 2 2 2 1 TPR repeat TPR_17 PF13431.1 ESS62970.1 - 0.00015 21.6 0.5 0.01 15.9 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS62970.1 - 0.001 19.7 2.9 0.001 19.7 2.0 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESS62970.1 - 0.0027 17.4 2.4 10 6.3 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS62970.1 - 0.0038 17.1 3.8 0.017 15.0 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS62970.1 - 0.011 15.2 0.4 13 5.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2674 PF10879.3 ESS62970.1 - 0.067 12.9 0.3 0.8 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2674) TPR_6 PF13174.1 ESS62970.1 - 0.07 13.6 4.4 8.3 7.1 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Rapsyn_N PF10579.4 ESS62970.1 - 0.072 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region TPR_10 PF13374.1 ESS62970.1 - 4.4 7.3 8.8 0.49 10.4 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2040 PF09745.4 ESS62972.1 - 0.018 14.8 8.5 0.018 14.8 5.9 2.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) DUF3552 PF12072.3 ESS62972.1 - 0.85 8.7 46.3 0.17 11.0 4.1 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF3552) DUF2452 PF10504.4 ESS62972.1 - 0.97 8.6 9.4 0.091 12.0 1.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2452) GAGA_bind PF06217.7 ESS62972.1 - 3.9 7.3 12.1 6.1 6.7 7.2 1.8 1 1 1 2 2 2 0 GAGA binding protein-like family RNase_H PF00075.19 ESS62973.1 - 2.7e-27 95.7 0.0 1.3e-26 93.4 0.0 2.1 2 1 0 2 2 2 1 RNase H Cauli_VI PF01693.11 ESS62973.1 - 3.2e-16 59.0 0.1 5.4e-16 58.3 0.1 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin FHA PF00498.21 ESS62974.1 - 0.0025 17.8 0.0 0.0052 16.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain Pneumo_phosprot PF02478.11 ESS62975.1 - 0.073 12.5 1.2 0.11 11.9 0.8 1.3 1 0 0 1 1 1 0 Pneumovirus phosphoprotein XRN_N PF03159.13 ESS62976.1 - 1.5e-50 171.7 0.0 3e-50 170.8 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Leu_zip PF15294.1 ESS62977.1 - 6.9e-08 31.9 13.9 6.2e-06 25.5 7.9 2.1 2 0 0 2 2 2 2 Leucine zipper TMF_DNA_bd PF12329.3 ESS62977.1 - 0.069 12.9 12.3 0.21 11.4 3.1 2.7 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Antigen_Bd37 PF11641.3 ESS62977.1 - 0.096 11.9 2.5 0.13 11.5 0.5 1.9 1 1 1 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein DUF4201 PF13870.1 ESS62977.1 - 0.22 10.9 11.8 0.85 9.0 1.6 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Vps5 PF09325.5 ESS62977.1 - 0.35 10.0 10.9 1.5 8.0 1.7 2.2 1 1 1 2 2 2 0 Vps5 C terminal like HD_5 PF13487.1 ESS62977.1 - 0.37 10.8 2.4 31 4.6 0.0 3.1 3 1 0 3 3 3 0 HD domain V_ATPase_I PF01496.14 ESS62977.1 - 0.48 8.2 2.8 0.64 7.7 1.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-Q PF13094.1 ESS62977.1 - 0.72 9.8 12.9 1.3 8.9 8.9 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4298 PF14131.1 ESS62977.1 - 1.6 8.6 4.6 4.3 7.2 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) TBPIP PF07106.8 ESS62977.1 - 2.9 7.4 9.6 1.9 8.0 1.8 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SlyX PF04102.7 ESS62977.1 - 3.6 8.0 9.7 0.92 9.9 0.5 3.1 2 1 0 2 2 2 0 SlyX DUF1635 PF07795.6 ESS62977.1 - 3.8 6.8 9.1 10 5.3 6.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) Atg14 PF10186.4 ESS62977.1 - 7.3 5.4 11.8 6.4 5.6 0.1 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 FHA PF00498.21 ESS62979.1 - 7.2e-14 51.6 0.0 1.8e-13 50.3 0.0 1.7 1 1 0 1 1 1 1 FHA domain BNR_3 PF13859.1 ESS62980.1 - 1.9e-57 194.7 0.1 2.7e-57 194.2 0.1 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS62980.1 - 1.7e-15 57.1 0.0 3.7e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62980.1 - 8.2e-14 52.1 0.1 1.6e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR PF02012.15 ESS62980.1 - 3.2e-05 23.1 2.5 0.055 13.3 0.2 3.2 2 0 0 2 2 2 2 BNR/Asp-box repeat Peptidase_M8 PF01457.11 ESS62982.1 - 8.5e-79 265.2 1.2 9.9e-79 265.0 0.9 1.0 1 0 0 1 1 1 1 Leishmanolysin Histone PF00125.19 ESS62983.1 - 1.7e-23 82.4 1.5 1.9e-23 82.3 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESS62983.1 - 6.8e-06 26.0 0.7 9.9e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESS62983.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated CENP-S PF15630.1 ESS62983.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Kinetochore component CENP-S EF-hand_1 PF00036.27 ESS62984.1 - 0.052 12.8 0.0 0.17 11.2 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 ESS62984.1 - 0.13 12.4 0.1 0.53 10.4 0.1 1.8 1 1 1 2 2 2 0 EF-hand domain pair BNR_3 PF13859.1 ESS62987.1 - 8e-38 130.2 0.7 1.4e-37 129.4 0.5 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS62987.1 - 1.6e-13 51.1 0.6 3.4e-13 50.1 0.4 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS62987.1 - 1.2e-09 37.8 14.5 4.1e-09 36.1 10.0 2.0 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal RHSP PF07999.6 ESS62989.1 - 6e-78 262.3 0.1 7.9e-78 262.0 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein TMEM52 PF14979.1 ESS62991.1 - 0.0072 16.2 0.4 0.011 15.6 0.3 1.3 1 0 0 1 1 1 1 Transmembrane 52 Enterotoxin_HS1 PF08090.6 ESS62992.1 - 5.2 6.8 8.1 6.7 6.5 5.1 1.6 1 1 0 1 1 1 0 Heat stable E.coli enterotoxin 1 Peptidase_M8 PF01457.11 ESS62996.1 - 0.00021 19.8 0.0 0.00033 19.1 0.0 1.2 1 0 0 1 1 1 1 Leishmanolysin Laminin_G_3 PF13385.1 ESS63001.1 - 2.8e-11 43.8 1.5 5.9e-11 42.8 1.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63001.1 - 8.1e-10 38.3 10.3 1.7e-09 37.3 7.2 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63002.1 - 8.3e-133 442.2 4.4 1e-132 441.9 3.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS63002.1 - 4e-05 23.0 0.0 5.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Mucin PF01456.12 ESS63004.1 - 7.9e-25 87.2 27.2 8.9e-25 87.1 18.8 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.6 ESS63004.1 - 0.0069 14.4 16.4 0.007 14.4 11.4 1.1 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 TraV PF09676.5 ESS63004.1 - 0.16 12.6 2.7 0.17 12.6 1.9 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DUF1675 PF07897.6 ESS63004.1 - 0.75 9.6 4.9 0.85 9.4 3.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Menin PF05053.8 ESS63004.1 - 1.4 6.9 3.7 1.3 7.0 2.6 1.0 1 0 0 1 1 1 0 Menin AJAP1_PANP_C PF15298.1 ESS63004.1 - 1.9 8.3 12.5 1.9 8.3 8.7 1.0 1 0 0 1 1 1 0 AJAP1/PANP C-terminus TMEM154 PF15102.1 ESS63004.1 - 2.1 8.0 6.5 2.3 7.9 4.5 1.2 1 0 0 1 1 1 0 TMEM154 protein family BAT2_N PF07001.6 ESS63004.1 - 2.2 8.5 8.1 2.6 8.3 5.6 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Dicty_REP PF05086.7 ESS63004.1 - 9.9 3.7 9.2 11 3.6 6.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Herpes_DNAp_acc PF04929.7 ESS63005.1 - 6.1 5.7 5.5 8.2 5.2 3.8 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor US22 PF02393.11 ESS63006.1 - 0.036 14.1 0.0 0.037 14.0 0.0 1.1 1 0 0 1 1 1 0 US22 like RVT_1 PF00078.22 ESS63007.1 - 0.055 12.8 0.0 0.076 12.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Mucin PF01456.12 ESS63008.1 - 5.4e-32 110.5 53.9 2.3e-30 105.2 37.4 2.0 1 1 0 1 1 1 1 Mucin-like glycoprotein FAM163 PF15069.1 ESS63008.1 - 0.005 17.4 4.3 0.0055 17.2 3.0 1.1 1 0 0 1 1 1 1 FAM163 family MGC-24 PF05283.6 ESS63008.1 - 0.041 13.6 24.0 0.048 13.4 16.6 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Shisa PF13908.1 ESS63008.1 - 0.055 13.6 8.3 0.077 13.1 5.8 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Pex14_N PF04695.8 ESS63008.1 - 0.22 11.5 7.4 0.26 11.3 5.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sec10 PF07393.6 ESS63008.1 - 0.57 8.3 2.3 0.67 8.0 1.6 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec10 PRCC PF10253.4 ESS63008.1 - 1.1 9.9 7.8 1.3 9.7 5.4 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF2413 PF10310.4 ESS63008.1 - 1.6 7.4 4.9 1.7 7.3 3.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) MCPVI PF02993.9 ESS63008.1 - 1.9 8.5 5.9 2 8.4 4.1 1.0 1 0 0 1 1 1 0 Minor capsid protein VI DUF2360 PF10152.4 ESS63008.1 - 2.2 8.5 8.1 2.6 8.3 5.6 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF1180 PF06679.7 ESS63008.1 - 3.2 7.6 12.8 15 5.4 8.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Med13_C PF06333.7 ESS63008.1 - 3.6 6.0 9.3 4.3 5.7 6.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal DUF515 PF04415.7 ESS63008.1 - 4 5.5 5.4 4.4 5.4 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Atrophin-1 PF03154.10 ESS63008.1 - 6.9 4.6 13.1 7.6 4.5 9.0 1.0 1 0 0 1 1 1 0 Atrophin-1 family Med3 PF11593.3 ESS63008.1 - 7.6 5.6 27.4 8.4 5.5 19.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TFIIA PF03153.8 ESS63008.1 - 9 6.0 7.0 10 5.9 4.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dicty_REP PF05086.7 ESS63008.1 - 9.3 3.8 15.5 12 3.5 10.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RHSP PF07999.6 ESS63012.1 - 2.2e-79 267.1 0.0 2.8e-79 266.7 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS63012.1 - 0.00088 19.4 0.0 0.092 12.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain Myb_DNA-bind_5 PF13873.1 ESS63012.1 - 0.66 9.9 3.0 2 8.3 0.0 3.0 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain Galactosyl_T PF01762.16 ESS63013.1 - 4e-06 26.5 0.2 0.0006 19.4 0.0 3.2 3 1 1 4 4 4 2 Galactosyltransferase RHSP PF07999.6 ESS63014.1 - 2.7e-64 217.3 0.9 5.1e-64 216.4 0.6 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_10 PF12846.2 ESS63014.1 - 0.1 12.0 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain RHSP PF07999.6 ESS63015.1 - 2.3e-33 115.4 0.0 3.5e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Bac_transf PF02397.11 ESS63015.1 - 0.02 14.0 0.0 0.087 11.9 0.0 1.9 2 0 0 2 2 2 0 Bacterial sugar transferase DUF2431 PF10354.4 ESS63015.1 - 0.079 12.9 0.1 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) BNR_3 PF13859.1 ESS63017.1 - 7.2e-46 156.6 0.0 9.8e-46 156.2 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS63017.1 - 3.2e-05 23.1 2.4 0.24 11.3 0.4 3.4 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.1 ESS63017.1 - 0.00058 19.2 3.3 0.0042 16.4 0.4 1.9 1 1 1 2 2 2 2 BNR repeat-like domain Kelch_1 PF01344.20 ESS63017.1 - 3.3 7.3 5.5 60 3.2 0.0 3.4 2 1 0 2 2 2 0 Kelch motif Laminin_G_3 PF13385.1 ESS63018.1 - 8.2e-14 52.1 0.7 8.2e-14 52.1 0.5 1.7 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63018.1 - 0.00087 19.1 12.0 0.0029 17.4 8.3 1.9 1 1 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Herpes_UL21 PF03252.8 ESS63020.1 - 0.02 13.3 0.5 0.043 12.2 0.4 1.7 1 1 0 1 1 1 0 Herpesvirus UL21 PP1c_bdg PF10488.4 ESS63020.1 - 0.13 11.4 0.3 0.19 10.8 0.2 1.3 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region DGF-1_5 PF11038.3 ESS63021.1 - 2.2e-158 525.6 18.3 2.2e-158 525.6 12.7 3.1 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_4 PF11024.3 ESS63021.1 - 7.8e-40 135.1 18.2 2.3e-39 133.6 12.6 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_C PF11040.3 ESS63021.1 - 2.8e-34 116.8 1.2 2.8e-34 116.8 0.8 2.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Arb1 PF09692.5 ESS63021.1 - 9.3 4.9 0.0 15 4.3 0.0 1.1 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Amidase PF01425.16 ESS63022.1 - 0.00013 20.9 0.0 0.075 11.8 0.0 2.4 2 0 0 2 2 2 2 Amidase PI3_PI4_kinase PF00454.22 ESS63023.1 - 0.022 14.2 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase BAF1_ABF1 PF04684.8 ESS63023.1 - 2.2 7.0 15.2 4.6 5.9 10.5 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Protamine_P2 PF00841.14 ESS63023.1 - 5.8 7.5 12.2 11 6.6 8.5 1.4 1 0 0 1 1 1 0 Sperm histone P2 YlqD PF11068.3 ESS63023.1 - 7.4 6.6 12.1 38 4.3 0.1 2.4 2 0 0 2 2 2 0 YlqD protein Mak10 PF04112.8 ESS63026.1 - 0.00011 21.5 0.0 0.00057 19.1 0.0 2.1 1 1 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase PDEase_I PF00233.14 ESS63027.1 - 5.7e-16 58.9 2.4 2.4e-15 56.9 1.6 1.9 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PCIF1_WW PF12237.3 ESS63028.1 - 1.5e-36 125.3 0.1 1.6e-35 121.9 0.0 2.1 2 0 0 2 2 2 1 Phosphorylated CTD interacting factor 1 WW domain FH2 PF02181.18 ESS63030.1 - 1.2e-47 162.6 0.1 1.9e-47 161.9 0.1 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain Med9 PF07544.8 ESS63030.1 - 0.053 13.2 1.6 0.093 12.4 0.0 2.3 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Sec63 PF02889.11 ESS63031.1 - 2e-77 260.4 0.0 5.5e-70 236.0 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 ESS63031.1 - 5.7e-36 123.5 0.0 1.4e-28 99.5 0.1 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESS63031.1 - 3e-08 33.7 0.0 2.7e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESS63031.1 - 3e-07 30.2 0.0 8.6e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESS63031.1 - 0.00017 21.7 0.5 0.0058 16.7 0.0 3.4 3 0 0 3 3 3 1 AAA domain PhoH PF02562.11 ESS63031.1 - 0.015 14.5 0.0 0.16 11.1 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.1 ESS63031.1 - 0.077 12.5 0.1 9.1 5.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Acyltransferase PF01553.16 ESS63033.1 - 4e-18 65.1 0.0 8.4e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase LRR_6 PF13516.1 ESS63034.1 - 3.3e-13 48.1 8.2 0.012 15.6 0.1 6.2 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.2 ESS63034.1 - 1.6e-07 30.8 11.0 0.036 13.6 0.0 3.8 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS63034.1 - 5.2e-05 22.9 9.0 0.4 10.4 0.1 4.5 3 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 ESS63034.1 - 0.00034 20.2 10.5 23 5.5 0.0 6.3 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS63034.1 - 0.037 14.1 11.7 65 4.4 0.2 6.3 6 0 0 6 6 6 0 Leucine rich repeat FHA PF00498.21 ESS63036.1 - 8.5e-05 22.6 0.2 0.00089 19.3 0.0 2.6 3 0 0 3 3 3 1 FHA domain BRCT PF00533.21 ESS63036.1 - 0.034 14.3 0.0 16 5.7 0.0 2.7 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain N6-adenineMlase PF10237.4 ESS63037.1 - 2.7e-35 121.4 0.1 1e-34 119.5 0.0 1.9 1 1 0 1 1 1 1 Probable N6-adenine methyltransferase Spectrin PF00435.16 ESS63037.1 - 0.043 14.1 8.4 1.5 9.1 0.1 4.2 3 1 1 4 4 4 0 Spectrin repeat Methyltransf_26 PF13659.1 ESS63037.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF4588 PF15251.1 ESS63039.1 - 0.0024 17.9 1.3 0.0048 16.8 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4588) DDT PF02791.12 ESS63039.1 - 0.044 13.5 0.2 1.3 8.8 0.0 2.4 1 1 1 2 2 2 0 DDT domain DUF3008 PF11450.3 ESS63039.1 - 0.066 13.3 2.5 0.14 12.3 1.7 1.4 1 0 0 1 1 1 0 Protein of unknwon function (DUF3008) ADIP PF11559.3 ESS63043.1 - 4.1e-05 23.5 4.8 9.7e-05 22.3 3.4 1.6 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Nup54 PF13874.1 ESS63043.1 - 0.0009 18.9 5.3 0.0019 17.8 3.7 1.5 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 GAS PF13851.1 ESS63043.1 - 0.0014 17.8 11.9 0.0014 17.8 8.3 1.7 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding ERM PF00769.14 ESS63043.1 - 0.0021 17.6 12.9 0.0043 16.6 8.9 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF869 PF05911.6 ESS63043.1 - 0.0027 16.0 11.8 0.073 11.2 1.5 2.6 1 1 2 3 3 3 2 Plant protein of unknown function (DUF869) MogR_DNAbind PF12181.3 ESS63043.1 - 0.022 14.5 0.7 0.041 13.6 0.5 1.4 1 0 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) HlyD PF00529.15 ESS63043.1 - 0.06 12.6 13.7 0.011 15.0 6.8 1.6 2 0 0 2 2 2 0 HlyD family secretion protein TPR_MLP1_2 PF07926.7 ESS63043.1 - 0.077 12.7 10.5 0.13 11.9 2.0 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein EzrA PF06160.7 ESS63043.1 - 0.18 9.9 11.3 0.26 9.4 7.8 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TMPIT PF07851.8 ESS63043.1 - 0.31 10.0 5.6 9.9 5.1 0.0 2.1 2 0 0 2 2 2 0 TMPIT-like protein DUF342 PF03961.8 ESS63043.1 - 0.35 9.2 4.5 0.51 8.6 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 ESS63043.1 - 0.44 10.1 12.3 0.8 9.2 8.5 1.3 1 0 0 1 1 1 0 IncA protein Scaffolding_pro PF11418.3 ESS63043.1 - 1.8 8.9 6.3 18 5.7 1.8 2.7 1 1 1 2 2 2 0 Phi29 scaffolding protein V_ATPase_I PF01496.14 ESS63043.1 - 2.2 6.0 5.3 3.2 5.4 3.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AF0941-like PF14591.1 ESS63043.1 - 2.5 8.1 7.2 0.64 10.0 1.4 2.5 2 2 1 3 3 3 0 AF0941-like Exonuc_VII_L PF02601.10 ESS63043.1 - 4.1 6.5 10.3 1.9 7.5 5.2 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Cortex-I_coil PF09304.5 ESS63043.1 - 6 6.9 14.8 28 4.8 9.0 2.5 1 1 1 2 2 2 0 Cortexillin I, coiled coil Fructosamin_kin PF03881.9 ESS63044.1 - 4.9e-67 225.9 0.0 5.9e-67 225.6 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 ESS63044.1 - 1.9e-11 44.2 0.0 2.5e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 ESS63044.1 - 0.011 14.9 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase APH_6_hur PF04655.9 ESS63044.1 - 0.044 12.9 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Mic1 PF07035.7 ESS63045.1 - 3.9e-08 32.8 0.1 7.3e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Pkinase PF00069.20 ESS63049.1 - 3.4e-63 213.2 0.0 5e-63 212.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63049.1 - 3.4e-45 154.1 0.0 5.4e-45 153.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Nop14 PF04147.7 ESS63049.1 - 0.0039 15.1 33.2 0.0056 14.6 23.0 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 ESS63049.1 - 0.066 11.2 21.4 0.11 10.4 14.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 ESS63049.1 - 0.096 11.1 33.2 0.18 10.2 23.0 1.3 1 0 0 1 1 1 0 Daxx Family Spore_coat_CotO PF14153.1 ESS63049.1 - 0.32 10.3 10.7 0.61 9.4 7.5 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Merozoite_SPAM PF07133.6 ESS63049.1 - 1 9.2 35.7 1.7 8.4 24.7 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SAPS PF04499.10 ESS63049.1 - 1.2 7.7 7.4 1.7 7.1 5.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC27 PF09507.5 ESS63049.1 - 2.6 7.1 18.0 4.3 6.4 12.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ycf1 PF05758.7 ESS63049.1 - 4.7 4.8 8.5 6.6 4.3 5.9 1.1 1 0 0 1 1 1 0 Ycf1 DUF1510 PF07423.6 ESS63049.1 - 7.5 5.8 29.6 12 5.1 20.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Dicty_REP PF05086.7 ESS63052.1 - 0.12 10.1 0.5 0.24 9.0 0.4 1.5 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4615 PF15393.1 ESS63052.1 - 0.44 10.7 17.2 0.081 13.1 1.4 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4615) Toxin_51 PF15531.1 ESS63052.1 - 1.1 9.0 5.1 1.7 8.4 0.0 2.9 3 0 0 3 3 3 0 Putative toxin 51 Mucin PF01456.12 ESS63054.1 - 3.3e-25 88.5 23.8 3.6e-25 88.3 16.5 1.0 1 0 0 1 1 1 1 Mucin-like glycoprotein BNR_3 PF13859.1 ESS63058.1 - 7.5e-127 422.6 4.2 1.2e-126 422.0 2.9 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63058.1 - 4.9e-17 62.5 0.6 1.5e-16 60.9 0.4 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63058.1 - 5.6e-09 35.7 10.5 1.4e-08 34.4 7.3 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS63058.1 - 0.0086 15.3 0.1 0.14 11.4 0.0 2.4 2 1 1 3 3 3 2 BNR repeat-like domain CtaG_Cox11 PF04442.9 ESS63060.1 - 0.52 10.1 2.2 0.57 9.9 1.5 1.3 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein CtaG/Cox11 DUF2890 PF11081.3 ESS63061.1 - 8.1 6.4 10.6 13 5.8 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) CCAP PF11105.3 ESS63062.1 - 0.016 14.9 0.2 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a DUF4263 PF14082.1 ESS63064.1 - 0.065 13.1 0.3 0.1 12.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4263) LEA_3 PF03242.8 ESS63064.1 - 1.8 8.8 4.7 8 6.7 0.2 2.3 1 1 1 2 2 2 0 Late embryogenesis abundant protein Tr-sialidase_C PF11052.3 ESS63066.1 - 6.4e-11 41.9 12.4 6.4e-11 41.9 8.6 2.3 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63072.1 - 8.5e-27 94.0 0.0 1.6e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63072.1 - 1.1e-11 45.1 0.0 3.5e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63072.1 - 2.5e-05 24.0 7.9 7.1e-05 22.6 5.4 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63073.1 - 1.2e-25 90.2 0.2 1.7e-25 89.7 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Gram_pos_anchor PF00746.16 ESS63073.1 - 2.2 8.1 7.4 2.2 8.2 0.3 3.4 3 0 0 3 3 3 0 Gram positive anchor Peptidase_M8 PF01457.11 ESS63074.1 - 0.038 12.3 0.0 0.042 12.2 0.0 1.1 1 0 0 1 1 1 0 Leishmanolysin ASRT PF07100.6 ESS63074.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.4 1 1 0 1 1 1 0 Anabaena sensory rhodopsin transducer BNR_3 PF13859.1 ESS63078.1 - 3.2e-106 354.9 3.7 3.2e-106 354.9 2.6 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63078.1 - 8.1e-18 65.1 1.5 1.4e-17 64.3 0.1 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63078.1 - 3.4e-10 39.6 14.4 9.5e-10 38.1 10.0 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal ABC2_membrane_3 PF12698.2 ESS63080.1 - 0.091 11.7 0.1 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Peptidase_M8 PF01457.11 ESS63082.1 - 1.7e-110 369.8 11.4 9.5e-110 367.3 7.9 1.8 1 1 0 1 1 1 1 Leishmanolysin Tr-sialidase_C PF11052.3 ESS63082.1 - 5.8e-12 45.2 6.8 5.8e-12 45.2 4.7 2.9 3 0 0 3 3 3 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Peptidase_M10 PF00413.19 ESS63082.1 - 0.034 13.8 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Matrixin Reprolysin_5 PF13688.1 ESS63082.1 - 0.034 14.0 0.7 0.083 12.8 0.0 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12 DNA_ligase_OB_2 PF14743.1 ESS63082.1 - 0.1 12.2 0.0 0.32 10.6 0.0 1.9 1 0 0 1 1 1 0 DNA ligase OB-like domain BNR_3 PF13859.1 ESS63085.1 - 8.4e-128 425.7 6.0 2e-127 424.5 4.1 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63085.1 - 7.9e-13 48.9 1.7 7.9e-13 48.9 1.2 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS63085.1 - 0.00029 20.2 0.3 0.00091 18.5 0.2 1.8 1 0 0 1 1 1 1 BNR repeat-like domain PapJ PF14855.1 ESS63085.1 - 0.043 13.2 0.0 2.6 7.4 0.0 2.5 2 0 0 2 2 2 0 Pilus-assembly fibrillin subunit, chaperone PUB PF09409.5 ESS63086.1 - 2.8e-13 49.4 0.1 4.9e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 PUB domain EAF PF09816.4 ESS63086.1 - 0.0026 17.6 0.1 0.005 16.7 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor FtsH_ext PF06480.10 ESS63086.1 - 0.0068 16.5 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 FtsH Extracellular DUF2161 PF09929.4 ESS63086.1 - 0.042 13.7 0.1 0.074 12.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2161) DUF3596 PF12167.3 ESS63086.1 - 0.11 12.0 1.2 5.4 6.6 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3596) Chorein_N PF12624.2 ESS63087.1 - 1.3e-20 73.0 0.0 2.7e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter zf-met PF12874.2 ESS63095.1 - 1.1e-05 25.4 1.7 2.5e-05 24.3 1.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 ESS63095.1 - 0.12 12.4 1.5 0.29 11.3 1.0 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding PRKCSH-like PF12999.2 ESS63095.1 - 0.45 10.0 4.8 0.17 11.4 1.7 1.5 2 0 0 2 2 2 0 Glucosidase II beta subunit-like PI3_PI4_kinase PF00454.22 ESS63096.1 - 3.1e-43 147.9 0.0 1.4e-42 145.8 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 ESS63096.1 - 4.3e-10 38.8 0.6 9.9e-10 37.6 0.1 1.9 2 0 0 2 2 2 1 FATC domain Ral PF11058.3 ESS63096.1 - 0.025 13.9 0.0 0.06 12.7 0.0 1.6 1 0 0 1 1 1 0 Antirestriction protein Ral Xpo1 PF08389.7 ESS63097.1 - 2.1e-19 69.9 1.4 2.2e-18 66.5 0.0 3.2 4 0 0 4 4 4 1 Exportin 1-like protein HEAT PF02985.17 ESS63097.1 - 0.018 15.0 0.8 30 5.0 0.1 4.4 3 0 0 3 3 3 0 HEAT repeat zf-CCCH PF00642.19 ESS63098.1 - 0.00093 18.8 18.4 0.0094 15.6 2.2 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SelR PF01641.13 ESS63100.1 - 0.0092 15.6 0.4 0.025 14.2 0.0 1.9 2 0 0 2 2 2 1 SelR domain VIT1 PF01988.14 ESS63102.1 - 0.008 15.6 0.2 0.016 14.6 0.2 1.5 1 0 0 1 1 1 1 VIT family MFS_1 PF07690.11 ESS63102.1 - 1.8 7.2 8.6 0.19 10.4 0.3 2.4 2 1 0 2 2 2 0 Major Facilitator Superfamily Hist_deacetyl PF00850.14 ESS63103.1 - 6.2e-78 262.2 0.9 1.9e-45 155.5 0.7 2.2 2 0 0 2 2 2 2 Histone deacetylase domain Daxx PF03344.10 ESS63103.1 - 0.09 11.2 13.0 0.13 10.7 9.0 1.1 1 0 0 1 1 1 0 Daxx Family Ribosomal_60s PF00428.14 ESS63103.1 - 0.11 12.9 4.0 0.3 11.5 2.7 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF4653 PF15546.1 ESS63103.1 - 0.11 11.7 5.1 0.19 11.0 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) Prothymosin PF03247.9 ESS63103.1 - 1.1 9.4 17.3 2.3 8.4 12.0 1.5 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF4366 PF14283.1 ESS63103.1 - 1.2 8.4 5.9 0.29 10.5 1.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Trypan_PARP PF05887.6 ESS63103.1 - 3.1 7.6 9.7 8.6 6.1 6.8 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3984 PF13136.1 ESS63104.1 - 0.074 12.2 1.2 0.1 11.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) SNAP PF14938.1 ESS63105.1 - 2.7e-25 89.1 7.3 4.5e-25 88.3 5.0 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DHHA1 PF02272.14 ESS63105.1 - 0.017 14.8 0.2 0.048 13.3 0.2 1.8 1 0 0 1 1 1 0 DHHA1 domain Ras PF00071.17 ESS63106.1 - 7.2e-59 197.7 0.3 9.9e-59 197.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS63106.1 - 3.5e-22 79.1 0.0 6.4e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS63106.1 - 4.3e-14 52.1 0.1 5.4e-14 51.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESS63106.1 - 5.9e-06 25.8 0.0 3.3e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESS63106.1 - 0.00026 20.1 0.1 0.00035 19.7 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESS63106.1 - 0.00069 18.8 0.1 0.0018 17.5 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESS63106.1 - 0.0023 17.8 0.0 0.0057 16.6 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESS63106.1 - 0.015 15.4 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESS63106.1 - 0.047 13.1 0.4 0.15 11.5 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNase_PH PF01138.16 ESS63107.1 - 4.2e-18 65.9 0.0 8.4e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Pro_3_hydrox_C PF05373.6 ESS63109.1 - 0.042 13.8 0.1 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal RDD PF06271.7 ESS63110.1 - 0.031 14.1 1.0 0.055 13.3 0.7 1.3 1 0 0 1 1 1 0 RDD family Fascin PF06268.8 ESS63111.1 - 0.00016 21.7 0.0 0.00035 20.6 0.0 1.7 1 0 0 1 1 1 1 Fascin domain SnoaL_4 PF13577.1 ESS63111.1 - 0.032 14.1 0.1 0.063 13.1 0.1 1.5 1 0 0 1 1 1 0 SnoaL-like domain RIC1 PF07064.8 ESS63112.1 - 2.1e-69 233.8 0.0 3.1e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 RIC1 Cyclin_N PF00134.18 ESS63113.1 - 1.7e-09 37.2 0.6 3.2e-09 36.4 0.4 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain ACPS PF01648.15 ESS63114.1 - 0.014 15.2 0.0 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase superfamily Epimerase PF01370.16 ESS63115.1 - 8.7e-56 188.9 0.0 1.3e-55 188.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESS63115.1 - 1.8e-10 40.2 0.0 3e-08 32.8 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESS63115.1 - 1.5e-07 30.6 0.5 3.5e-05 22.8 0.0 3.0 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESS63115.1 - 2.6e-05 23.0 0.6 0.00041 19.1 0.4 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 ESS63115.1 - 0.0024 16.8 0.0 0.028 13.3 0.0 2.0 1 1 1 2 2 2 1 Male sterility protein Semialdhyde_dh PF01118.19 ESS63115.1 - 0.072 13.4 0.0 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 ESS63115.1 - 0.17 11.8 0.2 4.3 7.2 0.0 2.8 1 1 1 2 2 2 0 NADH(P)-binding LRR_4 PF12799.2 ESS63116.1 - 3.5e-20 71.1 5.3 2.8e-08 33.2 0.5 3.9 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS63116.1 - 1.7e-14 53.3 27.1 3.7e-07 29.7 1.5 3.7 1 1 3 4 4 4 4 Leucine rich repeat LRR_9 PF14580.1 ESS63116.1 - 8e-08 32.0 0.1 6.2e-05 22.6 0.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 ESS63116.1 - 2.9e-06 26.5 10.1 0.64 10.2 0.1 6.3 5 1 1 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS63116.1 - 5.1e-06 26.0 12.5 0.8 9.9 0.1 5.8 6 1 1 7 7 7 3 Leucine Rich repeat LRR_7 PF13504.1 ESS63116.1 - 0.00016 21.2 11.6 0.1 12.8 0.2 5.8 5 1 0 5 5 5 2 Leucine rich repeat S4 PF01479.20 ESS63118.1 - 2e-06 27.1 0.0 5e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 S4 domain Kinesin PF00225.18 ESS63119.1 - 2.6e-101 338.6 0.1 2.6e-101 338.6 0.1 2.6 3 0 0 3 3 3 1 Kinesin motor domain Trypsin_2 PF13365.1 ESS63120.1 - 0.0019 18.1 0.0 0.019 14.9 0.0 2.3 2 1 0 2 2 2 1 Trypsin-like peptidase domain AKAP7_NLS PF10469.4 ESS63121.1 - 3.1e-41 141.3 0.0 3.7e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 ESS63121.1 - 1.1e-08 34.8 0.0 1.6e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.11 ESS63121.1 - 0.00052 19.9 0.1 0.16 11.9 0.0 2.6 1 1 0 2 2 2 2 LigT like Phosphoesterase WD40 PF00400.27 ESS63123.1 - 4.1e-15 55.0 7.3 0.0071 16.1 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat FmdA_AmdA PF03069.10 ESS63124.1 - 0.052 12.2 0.0 0.096 11.3 0.0 1.3 1 0 0 1 1 1 0 Acetamidase/Formamidase family PLAC9 PF15205.1 ESS63124.1 - 0.075 13.3 0.1 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Placenta-specific protein 9 DnaJ PF00226.26 ESS63125.1 - 1e-08 34.8 0.0 2.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Acetyltransf_11 PF13720.1 ESS63125.1 - 0.0043 17.2 0.3 0.19 11.9 0.0 2.6 2 0 0 2 2 2 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Folliculin PF11704.3 ESS63125.1 - 0.02 14.4 2.3 0.026 14.1 0.5 2.1 1 1 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2654 PF10849.3 ESS63125.1 - 4.6 7.0 7.0 13 5.5 2.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2654) DEAD PF00270.24 ESS63127.1 - 2.1e-31 108.6 0.3 5.8e-31 107.2 0.0 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS63127.1 - 1.9e-24 85.3 0.1 4e-24 84.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS63127.1 - 5e-07 29.7 0.0 1.5e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESS63127.1 - 0.032 13.0 0.0 0.068 11.9 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain Helicase_C_2 PF13307.1 ESS63127.1 - 0.038 13.9 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain TauE PF01925.14 ESS63128.1 - 1.9e-17 63.5 29.9 6.2e-11 42.1 4.8 2.2 1 1 1 2 2 2 2 Sulfite exporter TauE/SafE CDC50 PF03381.10 ESS63129.1 - 2e-75 253.5 0.2 2.5e-75 253.2 0.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family BNR_3 PF13859.1 ESS63130.1 - 1.4e-41 142.5 0.0 1.4e-41 142.5 0.0 1.4 2 0 0 2 2 2 1 BNR repeat-like domain DGF-1_4 PF11024.3 ESS63132.1 - 1.1e-32 112.1 10.4 3.7e-32 110.5 7.2 2.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_5 PF11038.3 ESS63132.1 - 1.8e-12 47.0 0.0 1.8e-12 47.0 0.0 3.9 4 1 1 5 5 5 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 RCC_reductase PF06405.6 ESS63134.1 - 0.11 11.3 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) BNR_3 PF13859.1 ESS63135.1 - 2.1e-134 447.4 7.2 2.5e-134 447.2 5.0 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS63135.1 - 0.00019 20.8 0.1 0.0003 20.1 0.1 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63136.1 - 5e-12 46.3 0.1 9.6e-12 45.4 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63136.1 - 0.016 15.1 1.4 0.036 13.9 0.9 1.6 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS63138.1 - 3.9e-31 107.7 52.4 2.1e-21 76.2 16.0 2.7 1 1 1 2 2 2 2 Mucin-like glycoprotein BNR_3 PF13859.1 ESS63141.1 - 1.9e-129 431.2 6.0 2.2e-129 430.9 4.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS63141.1 - 0.00084 18.7 0.1 0.0017 17.7 0.1 1.5 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS63147.1 - 1.1e-62 211.8 0.0 1.9e-62 211.1 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63147.1 - 5.8e-15 55.8 0.6 2.5e-14 53.7 0.0 2.4 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63147.1 - 6.9e-07 29.0 9.2 6.9e-07 29.0 6.4 1.9 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS63147.1 - 0.00025 20.4 4.6 0.24 11.3 0.4 3.5 2 0 0 2 2 2 2 BNR/Asp-box repeat Tr-sialidase_C PF11052.3 ESS63148.1 - 1.2e-05 25.0 0.8 2e-05 24.3 0.6 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS63148.1 - 3.8e-05 23.9 0.3 7.3e-05 23.0 0.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CusF_Ec PF11604.3 ESS63148.1 - 0.099 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF DUF2028 PF09667.5 ESS63149.1 - 0.037 14.1 0.2 0.064 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2028) RHSP PF07999.6 ESS63150.1 - 8.7e-94 314.5 0.3 1.3e-93 314.0 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein MutL_C PF08676.6 ESS63153.1 - 0.029 13.9 0.0 0.29 10.7 0.0 2.2 2 0 0 2 2 2 0 MutL C terminal dimerisation domain Pkinase PF00069.20 ESS63155.1 - 6.8e-08 31.9 0.0 5.6e-07 28.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESS63156.1 - 3.2e-09 36.3 0.0 4.8e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63156.1 - 0.00026 20.1 0.0 0.0004 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESS63156.1 - 0.1 11.3 0.1 0.22 10.2 0.0 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Btz PF09405.5 ESS63157.1 - 0.0067 16.4 0.0 0.0097 15.9 0.0 1.2 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding DUF3357 PF11837.3 ESS63157.1 - 0.0087 15.9 0.5 1.4 8.8 0.0 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF3357) Myb_DNA-binding PF00249.26 ESS63160.1 - 2.9e-18 65.6 4.8 3.7e-09 36.5 0.1 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESS63160.1 - 7.6e-17 61.1 7.7 4.2e-08 33.1 0.3 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ESS63160.1 - 0.018 15.1 12.0 0.42 10.7 0.1 4.3 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain XylR_N PF06505.6 ESS63160.1 - 0.056 12.8 0.0 0.23 10.9 0.0 2.0 1 0 0 1 1 1 0 Activator of aromatic catabolism DUF192 PF02643.10 ESS63161.1 - 0.13 11.9 0.0 0.33 10.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized ACR, COG1430 IMPDH PF00478.20 ESS63162.1 - 5.8e-131 436.5 5.0 6.6e-131 436.3 3.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 ESS63162.1 - 3.2e-12 46.0 0.0 6.5e-06 25.8 0.1 2.7 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 ESS63162.1 - 9.1e-07 28.0 5.6 2.2e-06 26.7 3.9 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.10 ESS63162.1 - 1e-05 24.8 12.5 0.054 12.6 6.0 3.3 2 1 1 3 3 3 2 Nitronate monooxygenase PcrB PF01884.12 ESS63162.1 - 2e-05 23.9 10.9 0.00093 18.5 0.2 3.7 2 1 2 4 4 4 2 PcrB family ThiG PF05690.9 ESS63162.1 - 0.00097 18.2 3.2 0.003 16.6 0.3 2.4 3 0 0 3 3 3 1 Thiazole biosynthesis protein ThiG DHO_dh PF01180.16 ESS63162.1 - 0.0012 17.8 4.7 0.063 12.2 0.4 2.3 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase His_biosynth PF00977.16 ESS63162.1 - 0.0018 17.5 3.4 0.016 14.4 0.2 2.4 1 1 0 2 2 2 1 Histidine biosynthesis protein Glu_synthase PF01645.12 ESS63162.1 - 0.0085 15.0 6.1 0.022 13.6 4.2 1.6 1 1 0 1 1 1 1 Conserved region in glutamate synthase TMP-TENI PF02581.12 ESS63162.1 - 0.027 13.6 5.1 0.62 9.1 0.2 2.4 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI Methyltransf_20 PF12147.3 ESS63162.1 - 0.11 11.3 0.1 0.24 10.2 0.1 1.5 1 0 0 1 1 1 0 Putative methyltransferase ParA PF10609.4 ESS63162.1 - 0.12 12.2 2.8 37 4.2 0.0 4.1 4 1 0 4 4 4 0 ParA/MinD ATPase like Kinesin PF00225.18 ESS63163.1 - 2.2e-104 348.7 0.0 2.2e-104 348.7 0.0 2.5 3 0 0 3 3 3 1 Kinesin motor domain Cortex-I_coil PF09304.5 ESS63163.1 - 0.0062 16.5 8.0 0.0062 16.5 5.6 8.1 4 2 4 8 8 8 1 Cortexillin I, coiled coil RRM_1 PF00076.17 ESS63164.1 - 0.0012 18.4 0.0 2.3 7.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS63164.1 - 0.0089 15.8 0.2 0.77 9.6 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Miff PF05644.6 ESS63164.1 - 0.021 14.4 0.6 0.021 14.4 0.4 2.7 3 0 0 3 3 3 0 Mitochondrial and peroxisomal fission factor Mff Gon7 PF08738.5 ESS63164.1 - 0.52 10.3 7.4 1.6 8.7 0.6 2.9 2 0 0 2 2 2 0 Gon7 family Viral_P18 PF04521.8 ESS63164.1 - 0.7 9.3 8.0 0.27 10.6 0.9 2.9 2 1 1 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein ACT_5 PF13710.1 ESS63164.1 - 1.1 9.1 5.9 0.9 9.3 1.7 2.4 2 0 0 2 2 2 0 ACT domain CK2S PF15011.1 ESS63164.1 - 1.3 8.8 15.0 0.051 13.3 2.9 2.4 2 0 0 2 2 2 0 Casein Kinase 2 substrate G-patch PF01585.18 ESS63165.1 - 2.9e-13 49.3 0.1 6.8e-13 48.1 0.1 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESS63165.1 - 0.001 18.8 0.1 0.001 18.8 0.1 1.8 2 0 0 2 2 2 1 DExH-box splicing factor binding site CD52 PF15116.1 ESS63167.1 - 3.4 7.5 10.2 0.48 10.2 0.1 3.6 2 1 1 3 3 3 0 CAMPATH-1 antigen DBR1 PF05011.8 ESS63168.1 - 1.4e-07 31.4 0.0 3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain UPF1_Zn_bind PF09416.5 ESS63169.1 - 9.8e-64 213.5 3.4 1.7e-63 212.7 2.3 1.4 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 ESS63169.1 - 7e-62 208.3 0.0 1.2e-61 207.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESS63169.1 - 9.8e-54 182.4 0.1 1.4e-53 181.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS63169.1 - 2.4e-16 59.2 0.8 1.6e-15 56.5 0.8 2.3 2 0 0 2 2 1 1 Part of AAA domain AAA_30 PF13604.1 ESS63169.1 - 7.9e-12 45.1 0.0 2.1e-10 40.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 ESS63169.1 - 8.6e-05 22.4 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 ESS63169.1 - 0.00021 20.7 0.0 0.19 10.9 0.0 2.4 1 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain PhoH PF02562.11 ESS63169.1 - 0.0013 18.0 0.0 0.0026 17.0 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein Helicase_RecD PF05127.9 ESS63169.1 - 0.0017 17.9 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 Helicase DEAD PF00270.24 ESS63169.1 - 0.0019 17.7 0.1 0.0071 15.8 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.4 ESS63169.1 - 0.0065 15.4 0.3 0.025 13.5 0.0 2.1 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.13 ESS63169.1 - 0.0079 15.7 0.1 1.4 8.3 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 ESS63169.1 - 0.012 15.5 0.7 0.025 14.5 0.1 1.8 2 0 0 2 2 1 0 AAA ATPase domain AAA PF00004.24 ESS63169.1 - 0.023 14.9 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.9 ESS63169.1 - 0.034 13.8 0.1 0.075 12.7 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain T2SE PF00437.15 ESS63169.1 - 0.036 12.9 0.0 0.066 12.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 ESS63169.1 - 0.043 13.9 0.0 0.58 10.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 ESS63169.1 - 0.075 13.3 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-UBP PF02148.14 ESS63169.1 - 0.27 11.3 6.9 0.69 10.0 4.8 1.7 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein ATP-synt_10 PF05176.9 ESS63170.1 - 2.6e-06 26.9 0.0 1.1e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 ATP10 protein Fer4_8 PF13183.1 ESS63172.1 - 0.028 14.4 2.1 0.044 13.8 1.5 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain Nucleoplasmin PF03066.10 ESS63177.1 - 0.0066 15.9 7.4 0.0083 15.6 5.1 1.2 1 0 0 1 1 1 1 Nucleoplasmin Sporozoite_P67 PF05642.6 ESS63177.1 - 0.015 13.1 0.3 0.017 13.0 0.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.1 ESS63177.1 - 0.064 13.5 6.0 0.097 12.9 4.1 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EBV-NA3 PF05009.7 ESS63177.1 - 1.2 8.3 5.1 1.7 7.8 3.5 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Sigma70_ner PF04546.8 ESS63177.1 - 1.8 8.1 7.4 2.3 7.7 5.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.7 ESS63177.1 - 2.3 6.0 12.0 2.8 5.7 8.3 1.0 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.6 ESS63177.1 - 3.5 7.1 12.0 4.3 6.7 8.3 1.1 1 0 0 1 1 1 0 PPP4R2 Daxx PF03344.10 ESS63177.1 - 6.7 5.0 11.3 8.4 4.7 7.9 1.0 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESS63177.1 - 8.3 4.3 6.3 10 3.9 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein BNR_3 PF13859.1 ESS63178.1 - 7.4e-62 209.1 0.4 7.4e-62 209.1 0.3 1.9 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63178.1 - 1.1e-19 71.1 3.0 2.8e-19 69.8 2.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63178.1 - 1.4e-11 44.0 7.7 3.1e-11 42.9 5.3 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Rib_hydrolayse PF02267.12 ESS63179.1 - 0.085 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosyl cyclase RuvA_C PF07499.8 ESS63181.1 - 0.05 13.7 0.0 0.091 12.9 0.0 1.4 1 0 0 1 1 1 0 RuvA, C-terminal domain Filo_glycop PF01611.11 ESS63183.1 - 4.4 5.9 8.8 5.1 5.7 6.1 1.3 1 0 0 1 1 1 0 Filovirus glycoprotein FLO_LFY PF01698.11 ESS63184.1 - 0.0057 15.5 0.1 0.0064 15.3 0.0 1.0 1 0 0 1 1 1 1 Floricaula / Leafy protein DUF4094 PF13334.1 ESS63184.1 - 0.028 14.7 0.1 0.036 14.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) WBP-1 PF11669.3 ESS63184.1 - 0.082 12.9 0.4 0.094 12.8 0.2 1.3 1 1 0 1 1 1 0 WW domain-binding protein 1 Neur_chan_memb PF02932.11 ESS63184.1 - 0.087 12.6 0.9 0.1 12.5 0.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ctr PF04145.10 ESS63184.1 - 0.092 12.7 0.2 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Ctr copper transporter family NicO PF03824.11 ESS63184.1 - 0.15 11.3 0.6 0.16 11.2 0.4 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein BNR_3 PF13859.1 ESS63185.1 - 3e-131 437.1 7.5 3e-131 437.1 5.2 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63185.1 - 4.5e-19 69.2 0.3 1.2e-18 67.8 0.2 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63185.1 - 7.6e-10 38.4 9.0 1.5e-09 37.5 6.2 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DHQ_synthase PF01761.15 ESS63187.1 - 0.16 10.9 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase PAT1 PF09770.4 ESS63188.1 - 0.42 8.7 7.6 0.46 8.6 5.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF605 PF04652.11 ESS63188.1 - 0.57 9.5 17.2 0.73 9.1 11.9 1.1 1 0 0 1 1 1 0 Vta1 like Ctr PF04145.10 ESS63190.1 - 2.4 8.1 4.9 7.9 6.5 3.4 1.9 1 1 0 1 1 1 0 Ctr copper transporter family Laminin_G_3 PF13385.1 ESS63192.1 - 6.3e-14 52.5 0.8 1.2e-13 51.6 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63192.1 - 1.1e-09 38.0 11.3 1.9e-09 37.2 7.8 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63193.1 - 9.6e-135 448.5 7.3 1.3e-134 448.1 5.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF2909 PF11137.3 ESS63193.1 - 0.083 12.6 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Peptidase_M8 PF01457.11 ESS63196.1 - 0.0046 15.3 0.1 0.0066 14.8 0.1 1.1 1 0 0 1 1 1 1 Leishmanolysin Phage_fiber_2 PF03406.8 ESS63198.1 - 0.4 10.3 0.2 0.4 10.3 0.2 2.0 2 0 0 2 2 2 0 Phage tail fibre repeat Peptidase_S10 PF00450.17 ESS63199.1 - 3.5e-113 378.9 0.8 4.3e-113 378.6 0.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 ESS63199.1 - 4.8e-07 29.8 0.0 4.3e-06 26.7 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESS63199.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESS63199.1 - 0.013 15.2 0.0 0.03 14.0 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS63199.1 - 0.021 14.0 0.1 0.099 11.8 0.1 2.1 2 1 0 2 2 2 0 Prolyl oligopeptidase family Cpn60_TCP1 PF00118.19 ESS63200.1 - 4.2e-139 464.3 7.7 4.8e-139 464.1 5.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pkinase PF00069.20 ESS63201.1 - 2.4e-75 253.0 0.0 2.7e-75 252.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63201.1 - 5.5e-33 114.1 0.0 6.2e-33 113.9 0.0 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS63201.1 - 0.00013 21.7 0.3 0.37 10.4 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS63201.1 - 0.01 14.9 0.1 0.025 13.6 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinesin PF00225.18 ESS63202.1 - 4.1e-85 285.4 0.6 1e-84 284.1 0.4 1.7 1 0 0 1 1 1 1 Kinesin motor domain CCDC66 PF15236.1 ESS63203.1 - 0.015 14.9 38.9 0.055 13.0 26.9 1.9 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 66 Ax_dynein_light PF10211.4 ESS63204.1 - 5.2e-31 107.9 0.0 6.6e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain Tubulin PF00091.20 ESS63205.1 - 6.7e-70 235.2 0.0 1e-69 234.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESS63205.1 - 2.9e-24 85.5 0.0 6.2e-24 84.4 0.0 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESS63205.1 - 0.00092 19.2 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.1 ESS63205.1 - 0.031 13.2 0.1 0.054 12.4 0.0 1.5 1 0 0 1 1 1 0 Tubulin like DUF972 PF06156.8 ESS63206.1 - 1.5 9.1 11.9 0.51 10.6 1.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF4201 PF13870.1 ESS63206.1 - 3.2 7.1 25.6 0.43 9.9 4.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) Clathrin PF00637.15 ESS63207.1 - 8.4e-09 35.1 26.0 0.045 13.3 0.0 9.4 7 2 2 10 10 10 2 Region in Clathrin and VPS WD40 PF00400.27 ESS63207.1 - 6.9e-08 32.0 3.8 0.19 11.6 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESS63207.1 - 0.0002 20.2 12.0 0.018 13.8 0.2 5.7 5 2 1 7 7 7 2 Coatomer WD associated region MORN_2 PF07661.8 ESS63207.1 - 0.053 13.5 0.2 2.4 8.4 0.1 3.3 2 0 0 2 2 2 0 MORN repeat variant TPR_1 PF00515.23 ESS63207.1 - 0.28 10.8 38.7 1.5 8.5 1.2 11.4 13 1 1 14 14 14 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63207.1 - 1.1 9.8 11.2 83 3.9 0.3 7.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63207.1 - 1.2 9.0 33.9 2.4 8.1 0.9 9.2 8 3 1 9 9 9 0 Tetratricopeptide repeat PPR PF01535.15 ESS63207.1 - 1.5 8.9 16.9 7 6.8 0.3 7.3 9 0 0 9 9 9 0 PPR repeat PDCD2_C PF04194.8 ESS63210.1 - 2.3e-38 131.3 0.0 3.7e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Arc_trans_TRASH PF08394.5 ESS63210.1 - 4.5 7.5 7.0 3.6 7.8 0.4 3.3 3 0 0 3 3 3 0 Archaeal TRASH domain AAA PF00004.24 ESS63212.1 - 5.7e-42 143.0 0.0 9.4e-42 142.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESS63212.1 - 1.2e-07 31.5 0.0 3.8e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 ESS63212.1 - 1.6e-05 25.0 0.3 0.00039 20.5 0.1 2.7 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.1 ESS63212.1 - 7.4e-05 22.6 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS63212.1 - 0.00022 20.9 0.3 0.0016 18.1 0.2 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESS63212.1 - 0.00045 20.1 0.0 0.0008 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.8 ESS63212.1 - 0.0005 18.8 0.0 0.00086 18.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 ESS63212.1 - 0.00051 20.0 0.0 0.0029 17.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 ESS63212.1 - 0.00056 19.3 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.1 ESS63212.1 - 0.0012 19.6 0.0 0.003 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESS63212.1 - 0.0018 17.3 0.0 0.0032 16.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESS63212.1 - 0.0019 17.9 0.1 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain Mg_chelatase PF01078.16 ESS63212.1 - 0.0032 16.6 0.0 0.0059 15.7 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 ESS63212.1 - 0.0035 17.2 0.0 0.0067 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESS63212.1 - 0.0039 16.6 0.5 0.14 11.5 0.3 2.4 1 1 1 2 2 2 1 AAA domain NACHT PF05729.7 ESS63212.1 - 0.0095 15.6 0.0 0.16 11.6 0.0 2.4 1 1 1 2 2 2 1 NACHT domain Bac_DnaA PF00308.13 ESS63212.1 - 0.012 15.2 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_24 PF13479.1 ESS63212.1 - 0.014 14.9 0.0 0.032 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESS63212.1 - 0.019 14.5 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 ESS63212.1 - 0.021 14.7 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESS63212.1 - 0.022 15.0 0.1 0.088 13.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESS63212.1 - 0.024 13.7 0.0 0.045 12.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 ESS63212.1 - 0.049 12.8 0.1 0.089 12.0 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.1 ESS63212.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESS63212.1 - 0.061 12.2 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 ESS63212.1 - 0.078 12.4 0.0 0.35 10.3 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain CPT PF07931.7 ESS63212.1 - 0.11 12.0 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein RNA_helicase PF00910.17 ESS63212.1 - 0.13 12.4 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.17 ESS63212.1 - 0.18 10.6 0.0 0.3 9.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.12 ESS63212.1 - 0.18 10.6 0.0 0.34 9.7 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 INCENP_N PF12178.3 ESS63213.1 - 0.065 12.7 0.0 0.17 11.4 0.0 1.8 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal tRNA_edit PF04073.10 ESS63214.1 - 2.6e-07 30.4 0.0 1.1e-06 28.4 0.0 1.9 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2 PF00152.15 ESS63215.1 - 2.4e-54 184.3 0.0 3.4e-54 183.8 0.0 1.2 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 ESS63215.1 - 9.5e-06 24.9 0.3 0.023 13.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Erythro_esteras PF05139.9 ESS63215.1 - 0.00029 20.1 0.0 0.56 9.3 0.0 2.1 2 0 0 2 2 2 2 Erythromycin esterase HMG_box_2 PF09011.5 ESS63216.1 - 2.5e-05 24.5 0.3 0.0029 17.9 0.0 2.6 2 0 0 2 2 2 2 HMG-box domain Tic20 PF09685.5 ESS63217.1 - 0.0015 18.4 1.5 0.0015 18.4 1.0 2.0 2 0 0 2 2 2 1 Tic20-like protein FtsH_ext PF06480.10 ESS63217.1 - 1.5 9.0 8.5 1.2 9.3 0.1 2.4 2 1 0 2 2 2 0 FtsH Extracellular Wyosine_form PF08608.7 ESS63219.1 - 3.8e-19 68.5 0.0 1.3e-18 66.7 0.0 2.0 2 0 0 2 2 2 1 Wyosine base formation Radical_SAM PF04055.16 ESS63219.1 - 4.1e-14 53.0 0.0 8e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Presenilin PF01080.12 ESS63220.1 - 6.1e-56 189.9 18.4 4e-41 141.1 2.6 2.0 1 1 1 2 2 2 2 Presenilin CorA PF01544.13 ESS63221.1 - 1.4e-19 70.2 0.1 2.5e-19 69.4 0.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Cohesin_load PF10345.4 ESS63221.1 - 0.0097 14.1 0.3 0.41 8.7 0.2 2.1 2 0 0 2 2 2 2 Cohesin loading factor Pkinase PF00069.20 ESS63222.1 - 2.7e-64 216.8 0.0 3.2e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63222.1 - 1.5e-29 102.8 0.0 1.4e-28 99.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESS63222.1 - 6.5e-21 74.0 11.9 1.3e-20 73.0 8.2 1.5 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESS63222.1 - 5.6e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS63222.1 - 0.0082 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.15 ESS63222.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase FYVE_2 PF02318.11 ESS63222.1 - 3.9 7.3 9.2 1.5 8.7 4.4 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger Cnd1 PF12717.2 ESS63223.1 - 5.8e-39 133.7 0.7 1.3e-37 129.3 0.0 3.0 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ESS63223.1 - 0.00018 21.7 0.1 0.021 15.0 0.0 3.7 2 1 2 4 4 4 3 HEAT repeats HEAT_EZ PF13513.1 ESS63223.1 - 0.00026 21.3 0.2 0.0021 18.4 0.0 2.8 2 1 1 3 3 3 1 HEAT-like repeat HEAT PF02985.17 ESS63223.1 - 0.0038 17.1 5.6 3.2 8.0 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat HEAT PF02985.17 ESS63224.1 - 6.3e-05 22.7 0.2 2.4 8.4 0.0 4.2 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.2 ESS63224.1 - 0.00011 22.1 0.8 0.046 13.5 0.1 2.9 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 ESS63224.1 - 0.0041 15.5 0.2 1.4 7.1 0.0 2.5 2 1 1 3 3 3 2 Adaptin N terminal region HEAT_2 PF13646.1 ESS63224.1 - 0.018 15.3 0.0 0.77 10.0 0.0 2.6 1 1 1 2 2 2 0 HEAT repeats V-ATPase_H_C PF11698.3 ESS63224.1 - 0.062 13.2 0.1 16 5.4 0.0 2.6 2 0 0 2 2 2 0 V-ATPase subunit H Oxidored_FMN PF00724.15 ESS63225.1 - 1.4e-82 277.4 0.0 1.8e-82 277.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.9 ESS63225.1 - 5.6e-15 55.7 0.0 1e-12 48.4 0.0 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS63225.1 - 4.3e-11 43.0 2.8 1.2e-05 25.6 0.3 4.6 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESS63225.1 - 5.8e-11 42.8 0.0 0.00022 21.3 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS63225.1 - 2.2e-10 40.4 0.3 1.9e-09 37.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESS63225.1 - 4.8e-10 38.8 2.7 7.3e-08 31.6 0.0 2.9 3 1 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.9 ESS63225.1 - 2.9e-07 29.2 0.4 6.3e-06 24.9 0.1 2.7 2 1 1 3 3 3 1 HI0933-like protein NAD_Gly3P_dh_N PF01210.18 ESS63225.1 - 6.9e-07 29.1 0.1 0.005 16.5 0.0 2.8 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K_oxygenase PF13434.1 ESS63225.1 - 9.1e-07 28.1 0.0 0.0048 15.8 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.2 ESS63225.1 - 2.7e-05 23.4 0.1 4e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase 3HCDH_N PF02737.13 ESS63225.1 - 2.9e-05 23.8 0.1 0.0069 16.0 0.0 2.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 ESS63225.1 - 5.4e-05 22.2 0.1 0.00012 21.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 ESS63225.1 - 0.00017 20.7 0.1 0.0029 16.7 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain F420_oxidored PF03807.12 ESS63225.1 - 0.00018 21.8 0.3 0.24 11.8 0.1 2.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Thi4 PF01946.12 ESS63225.1 - 0.00019 20.6 0.7 0.0014 17.7 0.0 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_10 PF13460.1 ESS63225.1 - 0.00027 20.9 0.0 0.64 9.9 0.0 2.4 2 0 0 2 2 2 2 NADH(P)-binding UDPG_MGDP_dh_N PF03721.9 ESS63225.1 - 0.00093 18.6 0.3 0.016 14.6 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Amino_oxidase PF01593.19 ESS63225.1 - 0.0011 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FMO-like PF00743.14 ESS63225.1 - 0.0013 17.0 0.2 0.048 11.8 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like GIDA PF01134.17 ESS63225.1 - 0.0013 17.6 0.0 0.0032 16.4 0.0 1.7 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_7 PF13241.1 ESS63225.1 - 0.0014 18.8 0.1 0.029 14.6 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding ApbA PF02558.11 ESS63225.1 - 0.0019 17.6 0.2 2.2 7.7 0.0 2.6 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.10 ESS63225.1 - 0.015 15.1 0.0 0.44 10.3 0.0 2.6 3 0 0 3 3 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_9 PF13454.1 ESS63225.1 - 0.033 13.9 2.5 0.12 12.0 0.0 2.9 4 0 0 4 4 4 0 FAD-NAD(P)-binding TrkA_N PF02254.13 ESS63225.1 - 0.04 13.9 0.2 6.8 6.7 0.0 2.8 3 0 0 3 3 2 0 TrkA-N domain DUF3489 PF11994.3 ESS63225.1 - 0.14 12.1 0.1 0.47 10.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) Shikimate_DH PF01488.15 ESS63225.1 - 0.23 11.5 0.7 16 5.5 0.0 2.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Laminin_G_3 PF13385.1 ESS63226.1 - 1.7e-13 51.1 2.1 1.8e-13 51.0 0.4 1.7 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63226.1 - 0.00021 21.0 4.4 0.00054 19.7 3.1 1.8 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3338 PF11819.3 ESS63227.1 - 0.092 12.2 0.1 0.098 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) DGF-1_5 PF11038.3 ESS63228.1 - 1.9e-159 529.1 17.2 1.9e-159 529.1 12.0 2.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS63228.1 - 1.8e-46 155.9 0.8 8.8e-46 153.7 0.6 2.3 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS63228.1 - 6.6e-39 132.1 16.9 1.6e-38 130.8 11.7 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 Glycos_transf_2 PF00535.21 ESS63230.1 - 0.0086 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS63230.1 - 0.0094 15.0 0.0 0.37 9.8 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESS63230.1 - 0.082 12.6 0.7 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase family group 2 DnaJ PF00226.26 ESS63233.1 - 7.7e-28 96.0 0.7 1.5e-27 95.0 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESS63233.1 - 2.8e-20 72.0 1.2 1e-16 60.5 0.0 3.6 3 1 1 4 4 4 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESS63233.1 - 9e-15 54.4 13.6 1.5e-14 53.7 9.5 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 ESS63233.1 - 0.0096 15.6 5.0 0.3 10.7 0.7 2.4 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family zf-RING_3 PF14369.1 ESS63233.1 - 0.23 11.5 5.6 32 4.6 0.0 4.3 4 0 0 4 4 4 0 zinc-finger zf-C3HC4_3 PF13920.1 ESS63233.1 - 0.81 9.4 5.5 1 9.0 0.2 2.9 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zinc-ribbons_6 PF07191.7 ESS63233.1 - 1.5 8.6 7.6 4.3 7.2 1.4 2.4 2 0 0 2 2 2 0 zinc-ribbons DZR PF12773.2 ESS63233.1 - 3.2 7.6 12.9 2.2 8.1 1.2 2.5 1 1 1 2 2 2 0 Double zinc ribbon Aldo_ket_red PF00248.16 ESS63234.1 - 1.9e-44 151.5 0.0 2.2e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family adh_short PF00106.20 ESS63236.1 - 2.3e-25 89.4 1.8 3.1e-25 89.0 1.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS63236.1 - 8.9e-15 54.8 1.2 2.6e-14 53.3 0.8 1.6 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESS63236.1 - 5.7e-10 39.3 0.0 6.9e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ESS63236.1 - 5e-08 32.6 0.1 3.6e-07 29.8 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESS63236.1 - 0.0077 16.2 0.1 0.009 16.0 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 ESS63236.1 - 0.068 12.0 0.1 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Pkinase PF00069.20 ESS63238.1 - 3.1e-53 180.5 0.0 3.8e-53 180.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63238.1 - 1.1e-24 86.9 0.0 1.3e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63238.1 - 5e-06 25.6 0.0 0.00044 19.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 ESS63238.1 - 3.6e-05 22.9 0.0 5.2e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS63238.1 - 0.0024 17.6 0.0 0.0035 17.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Prp19 PF08606.6 ESS63239.1 - 1.2e-29 101.7 1.5 2.2e-29 100.9 0.6 1.7 2 0 0 2 2 2 1 Prp19/Pso4-like zf-Nse PF11789.3 ESS63239.1 - 5.3e-05 22.6 0.3 0.00013 21.4 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 ESS63239.1 - 0.005 16.7 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain PBC PF03792.8 ESS63239.1 - 0.021 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 PBC domain Rtf2 PF04641.7 ESS63239.1 - 0.029 13.5 1.0 0.11 11.6 0.0 2.2 2 1 0 2 2 2 0 Rtf2 RING-finger WEMBL PF05701.6 ESS63239.1 - 0.029 12.8 0.0 0.038 12.4 0.0 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Streptin-Immun PF11083.3 ESS63239.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein Spore_YtfJ PF09579.5 ESS63239.1 - 0.075 12.8 0.2 0.075 12.8 0.1 1.6 2 0 0 2 2 2 0 Sporulation protein YtfJ (Spore_YtfJ) S1-P1_nuclease PF02265.11 ESS63239.1 - 0.077 12.6 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 S1/P1 Nuclease Sec10 PF07393.6 ESS63239.1 - 0.079 11.1 0.0 0.099 10.8 0.0 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec10 WD40 PF00400.27 ESS63240.1 - 4.6e-10 38.9 9.3 7.5e-06 25.6 0.2 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat TTL PF03133.10 ESS63241.1 - 8.8e-53 179.1 0.0 1.2e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESS63241.1 - 0.0014 18.4 0.0 0.0041 16.8 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 ESS63241.1 - 0.007 15.1 0.1 2 7.1 0.0 2.5 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.9 ESS63241.1 - 0.17 11.7 0.0 2.1 8.1 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain Acetyltransf_11 PF13720.1 ESS63242.1 - 0.082 13.1 1.1 0.11 12.7 0.7 1.2 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 HR1 PF02185.11 ESS63242.1 - 0.68 9.7 5.0 0.73 9.6 1.8 1.9 1 1 1 2 2 2 0 Hr1 repeat APO_RNA-bind PF05634.6 ESS63242.1 - 1.4 8.1 5.0 0.66 9.1 2.2 1.4 1 1 0 1 1 1 0 APO RNA-binding Atg14 PF10186.4 ESS63242.1 - 1.8 7.4 5.9 1.9 7.3 4.1 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 tRNA_synt_1c_R2 PF04557.10 ESS63242.1 - 3.5 8.3 7.2 0.66 10.7 0.7 2.0 1 1 1 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 HTH_12 PF08461.5 ESS63242.1 - 5 6.9 9.3 1.4 8.6 3.5 1.9 1 1 1 2 2 2 0 Ribonuclease R winged-helix domain Dynein_heavy PF03028.10 ESS63243.1 - 1e-213 711.3 0.0 4.4e-213 709.2 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESS63243.1 - 6.3e-108 360.8 6.8 6.3e-108 360.8 4.7 3.6 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS63243.1 - 2.7e-97 324.8 0.2 7.7e-97 323.3 0.0 1.9 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESS63243.1 - 4.4e-64 216.0 0.0 8.4e-64 215.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS63243.1 - 4.2e-49 166.4 0.5 4.2e-49 166.4 0.4 2.4 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 ESS63243.1 - 6.9e-47 159.8 0.0 1.1e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 ESS63243.1 - 4.8e-29 101.1 11.5 4.8e-29 101.1 7.9 2.2 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESS63243.1 - 7.9e-20 70.9 2.4 0.0002 21.1 0.0 6.9 8 1 0 8 8 6 3 AAA domain (dynein-related subfamily) AAA PF00004.24 ESS63243.1 - 1.9e-07 31.3 1.9 0.027 14.6 0.0 3.6 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS63243.1 - 7.8e-06 26.0 3.3 0.11 12.6 0.0 4.9 3 1 0 3 3 3 2 AAA domain AAA_17 PF13207.1 ESS63243.1 - 3.5e-05 24.5 0.3 0.013 16.2 0.0 4.1 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.1 ESS63243.1 - 0.00032 21.0 2.9 0.27 11.5 0.0 4.5 4 0 0 4 4 3 1 AAA domain Sigma54_activ_2 PF14532.1 ESS63243.1 - 0.0011 18.9 0.1 0.52 10.3 0.0 3.7 3 0 0 3 3 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 ESS63243.1 - 0.0018 17.8 0.3 0.62 9.6 0.1 3.1 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 ESS63243.1 - 0.0019 18.3 0.3 4.7 7.4 0.0 3.7 2 0 0 2 2 2 1 RNA helicase T2SE PF00437.15 ESS63243.1 - 0.0039 16.1 3.0 0.0066 15.3 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_33 PF13671.1 ESS63243.1 - 0.0078 16.0 0.3 3.5 7.4 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESS63243.1 - 0.0089 16.0 11.2 0.19 11.7 0.0 5.5 6 0 0 6 6 5 1 AAA ATPase domain Sigma54_activat PF00158.21 ESS63243.1 - 0.029 13.8 0.0 0.1 12.0 0.0 1.9 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.1 ESS63243.1 - 0.11 12.2 0.7 4.3 7.1 0.0 2.9 2 0 0 2 2 2 0 Part of AAA domain Mg_chelatase PF01078.16 ESS63243.1 - 2.4 7.2 4.9 1.2 8.3 0.0 3.0 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 ESS63243.1 - 9.2 6.5 5.6 17 5.6 0.1 3.6 2 0 0 2 2 2 0 ABC transporter BNR_3 PF13859.1 ESS63244.1 - 2.1e-31 109.1 0.4 2.4e-31 108.9 0.3 1.0 1 0 0 1 1 1 1 BNR repeat-like domain HN PF00423.14 ESS63244.1 - 0.034 12.4 0.0 0.044 12.0 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase BNR_3 PF13859.1 ESS63245.1 - 1.2e-23 83.6 1.0 1.6e-23 83.2 0.1 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63245.1 - 2.1e-07 31.2 0.0 8.4e-07 29.3 0.0 2.0 2 2 1 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily GRA6 PF05084.8 ESS63246.1 - 0.05 13.1 0.9 0.11 11.9 0.8 1.4 1 1 0 1 1 1 0 Granule antigen protein (GRA6) RHSP PF07999.6 ESS63249.1 - 2.4e-83 280.1 1.1 3.9e-83 279.4 0.7 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein RPAP3_C PF13877.1 ESS63250.1 - 7.4e-18 64.3 0.0 1.8e-17 63.0 0.0 1.7 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_11 PF13414.1 ESS63250.1 - 1.1e-17 63.3 2.1 2.7e-13 49.3 0.4 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESS63250.1 - 4.4e-14 51.3 3.0 0.00018 20.9 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS63250.1 - 1.7e-11 43.1 4.9 0.0022 17.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESS63250.1 - 1.2e-07 31.4 0.6 0.00031 20.5 0.9 3.5 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63250.1 - 4.4e-05 22.9 1.1 0.47 10.3 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS63250.1 - 7.2e-05 23.3 1.8 0.046 14.3 0.0 2.7 1 1 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS63250.1 - 0.00029 20.9 0.1 0.00074 19.6 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS63250.1 - 0.00037 20.8 2.2 0.16 12.6 0.1 3.5 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63250.1 - 0.0036 17.3 2.5 2.3 8.6 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63250.1 - 0.013 15.3 3.5 0.82 9.6 1.2 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63250.1 - 0.015 15.6 1.3 1.5 9.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS63250.1 - 0.13 12.1 2.8 0.91 9.4 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DIRP PF06584.8 ESS63250.1 - 2.4 8.0 10.6 0.16 11.8 3.4 2.0 2 0 0 2 2 2 0 DIRP TBPIP PF07106.8 ESS63251.1 - 3.4e-15 56.0 1.5 4.5e-15 55.6 1.0 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Choline_kinase PF01633.15 ESS63251.1 - 0.02 14.4 0.1 0.031 13.8 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase IncA PF04156.9 ESS63251.1 - 0.026 14.1 3.0 0.046 13.3 2.1 1.5 1 0 0 1 1 1 0 IncA protein ImcF-related_N PF14331.1 ESS63251.1 - 0.038 12.8 0.2 0.053 12.4 0.2 1.4 1 0 0 1 1 1 0 ImcF-related N-terminal domain Syntaxin_2 PF14523.1 ESS63251.1 - 0.081 12.9 6.3 0.25 11.3 4.3 1.9 1 1 0 1 1 1 0 Syntaxin-like protein HTH_5 PF01022.15 ESS63251.1 - 0.11 12.1 0.1 5.5 6.7 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family SlyX PF04102.7 ESS63251.1 - 0.14 12.5 5.3 1.7 9.0 1.8 2.8 1 1 1 2 2 2 0 SlyX DivIC PF04977.10 ESS63251.1 - 1 8.8 6.8 5.6 6.5 0.3 2.6 1 1 1 2 2 2 0 Septum formation initiator Med9 PF07544.8 ESS63251.1 - 4 7.2 6.9 4.6 7.0 0.1 2.9 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 CbiQ PF02361.11 ESS63252.1 - 0.25 10.8 3.6 0.19 11.2 1.8 1.3 1 1 0 1 1 1 0 Cobalt transport protein DUF4079 PF13301.1 ESS63252.1 - 0.53 10.2 3.2 0.6 10.0 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) Synaptobrevin PF00957.16 ESS63253.1 - 2.8e-29 100.5 0.3 8.3e-29 99.0 0.1 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.1 ESS63253.1 - 7.3e-17 60.7 0.2 1.2e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF2146 PF10220.4 ESS63253.1 - 0.016 13.2 0.1 0.019 13.0 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) RPW8 PF05659.6 ESS63253.1 - 0.096 12.2 0.1 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 PriCT_2 PF08707.6 ESS63256.1 - 9.7e-18 63.8 0.3 2.7e-17 62.4 0.2 1.8 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) DNA_primase_S PF01896.14 ESS63256.1 - 0.081 12.7 0.6 0.35 10.6 0.2 2.1 2 1 0 2 2 2 0 Eukaryotic and archaeal DNA primase small subunit SOBP PF15279.1 ESS63256.1 - 1.8 8.8 18.0 3.1 8.1 12.5 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein GFO_IDH_MocA PF01408.17 ESS63257.1 - 1.4e-06 28.8 0.1 3.2e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DUF4337 PF14235.1 ESS63258.1 - 0.14 11.9 3.6 0.36 10.6 2.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Sec10 PF07393.6 ESS63259.1 - 9.4e-28 96.8 0.1 7.5e-24 83.9 0.0 2.7 2 1 0 3 3 3 2 Exocyst complex component Sec10 TerD PF02342.13 ESS63259.1 - 0.0073 15.6 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 TerD domain BING4CT PF08149.6 ESS63261.1 - 1.2e-32 111.2 0.0 4.3e-32 109.4 0.0 2.0 1 1 1 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.27 ESS63261.1 - 3.4e-09 36.2 5.3 1.1e-06 28.2 0.0 3.2 4 0 0 4 4 4 2 WD domain, G-beta repeat Nucleo_P87 PF07267.6 ESS63261.1 - 1.8 7.1 11.5 2.3 6.8 8.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MYCBPAP PF14646.1 ESS63264.1 - 1.6e-11 43.5 0.2 3.7e-11 42.3 0.0 1.7 1 1 1 2 2 2 1 MYCBP-associated protein family DUF809 PF05663.6 ESS63264.1 - 3 7.7 6.2 5.6 6.8 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) DUF4106 PF13388.1 ESS63265.1 - 0.0081 15.1 0.0 0.012 14.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4106) Kinesin PF00225.18 ESS63266.1 - 1.9e-86 289.8 0.0 4.6e-86 288.5 0.0 1.7 1 0 0 1 1 1 1 Kinesin motor domain Peptidase_S10 PF00450.17 ESS63266.1 - 0.13 11.3 2.7 0.2 10.7 1.8 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase ThiF PF00899.16 ESS63267.1 - 1.2e-51 174.0 2.2 6.9e-33 113.3 0.0 2.4 2 0 0 2 2 2 2 ThiF family UBACT PF02134.16 ESS63267.1 - 9e-32 108.4 0.0 2.1e-21 75.2 0.0 3.4 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_C PF09358.5 ESS63267.1 - 2.7e-26 92.2 0.0 4.9e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBA_e1_thiolCys PF10585.4 ESS63267.1 - 2.9e-20 71.3 1.8 7.3e-20 70.0 1.2 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 ESS63267.1 - 0.0012 18.9 1.5 1 9.4 0.2 2.7 2 1 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 ESS63267.1 - 0.056 13.2 0.2 0.17 11.6 0.1 1.8 1 0 0 1 1 1 0 FAD-NAD(P)-binding Lactamase_B PF00753.22 ESS63268.1 - 1.2e-13 51.1 0.2 1.9e-08 34.1 0.1 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESS63268.1 - 0.01 15.4 0.1 0.016 14.7 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Tr-sialidase_C PF11052.3 ESS63269.1 - 4.4e-12 45.6 6.7 7.7e-12 44.8 4.6 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63269.1 - 0.0016 17.5 0.0 0.0017 17.4 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain RVT_1 PF00078.22 ESS63273.1 - 2.1e-15 56.6 0.0 3.5e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS63273.1 - 7.8e-09 35.9 0.0 1.4e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 RNase H EBP50_C-term PF09007.6 ESS63273.1 - 0.065 13.0 0.1 0.29 10.9 0.1 2.2 1 0 0 1 1 1 0 EBP50, C-terminal zf-C2H2_jaz PF12171.3 ESS63273.1 - 0.57 10.4 3.7 11 6.2 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESS63273.1 - 0.97 9.9 13.8 2.5 8.6 1.6 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type Exo_endo_phos_2 PF14529.1 ESS63274.1 - 8.6e-16 57.6 0.0 1.4e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS63274.1 - 2.9e-14 53.5 0.0 4.3e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BNR_3 PF13859.1 ESS63276.1 - 4.3e-132 439.8 5.1 1.3e-131 438.2 3.5 1.9 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63276.1 - 5.7e-20 72.1 0.2 2.3e-19 70.1 0.2 2.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63276.1 - 1.1e-09 37.9 13.4 2.2e-09 36.9 7.5 2.5 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal LMBR1 PF04791.11 ESS63281.1 - 3 6.3 5.6 4.1 5.8 3.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Vma12 PF11712.3 ESS63281.1 - 7.1 6.3 6.5 19 4.9 4.5 1.8 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2826 PF11442.3 ESS63283.1 - 1.5e-85 284.7 8.8 1.7e-85 284.5 6.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) RE_XcyI PF09571.5 ESS63285.1 - 0.14 10.9 0.8 0.15 10.8 0.5 1.1 1 0 0 1 1 1 0 XcyI restriction endonuclease Dsh_C PF12316.3 ESS63285.1 - 1.1 9.2 3.0 1.1 9.2 2.1 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal BNR_3 PF13859.1 ESS63287.1 - 6.2e-29 101.0 0.6 1.7e-28 99.5 0.1 2.0 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63287.1 - 7.5e-17 62.0 0.1 7.5e-17 62.0 0.1 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63287.1 - 1.6e-10 40.6 12.4 4.9e-10 39.0 8.6 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Mucin PF01456.12 ESS63290.1 - 0.012 15.4 1.1 0.015 15.0 0.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein BNR_3 PF13859.1 ESS63291.1 - 1.5e-19 70.2 0.0 1.8e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain DUF4159 PF13709.1 ESS63291.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) Gastrin PF00918.12 ESS63292.1 - 0.029 15.1 0.1 0.081 13.7 0.1 1.8 1 0 0 1 1 1 0 Gastrin/cholecystokinin family DUF3720 PF12517.3 ESS63293.1 - 3e-24 85.5 16.9 3e-24 85.5 11.7 4.5 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) vATP-synt_E PF01991.13 ESS63293.1 - 1.7 7.8 13.8 3.6 6.8 9.6 1.5 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit BNR_3 PF13859.1 ESS63294.1 - 3.1e-49 167.7 0.7 6.6e-49 166.6 0.2 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63294.1 - 1e-15 58.3 1.2 2.3e-15 57.1 0.8 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Alginate_exp PF13372.1 ESS63294.1 - 0.011 14.3 0.1 0.018 13.6 0.1 1.3 1 0 0 1 1 1 0 Alginate export Herpes_LMP1 PF05297.6 ESS63294.1 - 3.9 6.2 9.1 6.7 5.5 6.3 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) BNR_3 PF13859.1 ESS63296.1 - 5e-16 58.6 0.0 1.9e-14 53.4 0.0 2.0 1 1 0 1 1 1 1 BNR repeat-like domain DUF4159 PF13709.1 ESS63296.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) DUF3720 PF12517.3 ESS63297.1 - 1.3e-24 86.7 16.1 1.3e-24 86.7 11.2 4.0 2 1 2 4 4 4 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS63298.1 - 5.3e-128 426.4 3.3 7.2e-128 426.0 2.3 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63299.1 - 1.7e-14 54.3 0.4 1.7e-14 54.3 0.3 2.0 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63299.1 - 4.2e-11 42.5 11.1 7.5e-11 41.6 7.7 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Neisseria_TspB PF05616.8 ESS63299.1 - 1.9 6.7 5.3 2.3 6.5 3.7 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Mucin PF01456.12 ESS63300.1 - 2.8e-43 147.1 27.1 3.9e-43 146.6 18.8 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4569 PF15133.1 ESS63300.1 - 0.052 12.9 2.6 0.062 12.6 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF1675 PF07897.6 ESS63300.1 - 0.11 12.3 7.0 0.13 12.1 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Paramyxo_ncap PF00973.14 ESS63300.1 - 0.34 9.5 3.5 0.4 9.3 2.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein ArsD PF06953.6 ESS63300.1 - 0.7 10.0 4.4 0.57 10.3 1.9 1.7 1 1 1 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD Dicty_REP PF05086.7 ESS63300.1 - 8.6 3.9 9.4 8.9 3.9 6.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein B9-C2 PF07162.6 ESS63301.1 - 3.7e-33 114.6 0.0 5.8e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein zf-RING_2 PF13639.1 ESS63302.1 - 3.1e-14 52.5 5.3 5.3e-14 51.7 3.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESS63302.1 - 1.6e-10 40.9 7.9 3e-10 40.0 5.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESS63302.1 - 1.8e-07 31.0 4.8 3.6e-07 30.1 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS63302.1 - 6.2e-07 28.9 5.0 1.2e-06 28.1 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS63302.1 - 1.5e-06 27.7 4.4 2.8e-06 26.8 3.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS63302.1 - 2.2e-06 27.2 5.4 2.2e-06 27.2 3.8 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESS63302.1 - 4.4e-05 23.2 5.4 7.7e-05 22.4 3.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 ESS63302.1 - 0.0013 18.4 0.3 0.0039 16.9 0.2 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.3 ESS63302.1 - 0.0065 15.9 2.3 0.016 14.7 1.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.3 ESS63302.1 - 0.008 16.1 7.4 0.047 13.6 5.2 2.2 1 1 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.2 ESS63302.1 - 0.083 12.9 6.5 0.26 11.3 4.5 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_UBOX PF13445.1 ESS63302.1 - 0.086 12.5 3.5 0.12 12.1 0.7 2.4 1 1 1 2 2 2 0 RING-type zinc-finger PHD PF00628.24 ESS63302.1 - 1.3 8.7 7.5 3.4 7.4 5.2 1.8 1 1 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.1 ESS63302.1 - 4.9 6.8 6.5 11 5.6 3.7 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 ESS63302.1 - 8.1 6.4 7.2 37 4.2 4.5 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING V-SNARE PF05008.10 ESS63303.1 - 3.5e-08 33.4 0.2 0.00013 22.0 0.0 2.8 2 2 0 2 2 2 2 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 ESS63303.1 - 7.2e-07 29.1 3.1 2.2e-06 27.6 2.2 1.9 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 ESS63303.1 - 1.3e-06 28.0 0.1 1.3e-06 28.0 0.1 3.0 3 0 0 3 3 3 1 Sec20 PsbJ PF01788.12 ESS63303.1 - 0.0056 16.1 1.8 0.0089 15.5 0.6 1.7 2 0 0 2 2 2 1 PsbJ Tetraspannin PF00335.15 ESS63303.1 - 0.022 14.0 0.7 0.47 9.6 0.0 2.1 2 0 0 2 2 2 0 Tetraspanin family PLU-1 PF08429.6 ESS63303.1 - 0.031 13.1 0.2 0.042 12.7 0.1 1.3 1 0 0 1 1 1 0 PLU-1-like protein DUF4515 PF14988.1 ESS63303.1 - 0.097 12.3 3.5 0.054 13.1 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) Synaptobrevin PF00957.16 ESS63303.1 - 0.93 9.1 4.5 1.2 8.7 1.5 2.5 2 1 0 2 2 2 0 Synaptobrevin DUF4239 PF14023.1 ESS63303.1 - 4.7 6.5 5.9 0.47 9.7 0.6 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4239) BRCT PF00533.21 ESS63304.1 - 3.5e-07 30.2 0.0 1.2e-06 28.5 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Sigma54_activ_2 PF14532.1 ESS63304.1 - 0.12 12.4 0.0 11 6.0 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain EXOSC1 PF10447.4 ESS63305.1 - 3.4e-10 39.7 0.0 9.8e-10 38.2 0.0 1.8 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 Trichoplein PF13868.1 ESS63306.1 - 2.1e-11 42.8 128.9 2.1e-11 42.8 89.4 2.2 1 1 1 2 2 2 1 Tumour suppressor, Mitostatin Sulfate_transp PF00916.15 ESS63307.1 - 8.1e-33 113.6 10.9 8.1e-33 113.6 7.5 2.0 1 1 1 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 ESS63307.1 - 3.7e-13 48.9 5.1 3.7e-13 48.9 3.5 3.3 4 0 0 4 4 4 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 ESS63307.1 - 4.1e-06 26.1 0.0 8.3e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 STAS domain LRR_4 PF12799.2 ESS63308.1 - 2.1e-06 27.2 0.0 0.075 12.6 0.0 3.0 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS63308.1 - 1.9e-05 24.3 0.1 0.0039 16.9 0.1 2.5 2 1 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.1 ESS63308.1 - 0.003 17.1 0.1 0.0083 15.7 0.0 1.7 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.28 ESS63308.1 - 0.065 13.2 0.1 15 6.1 0.0 3.5 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_7 PF13504.1 ESS63308.1 - 0.13 12.5 0.0 27 5.5 0.0 3.2 3 0 0 3 3 3 0 Leucine rich repeat Nop14 PF04147.7 ESS63308.1 - 2.6 5.8 10.4 3.1 5.5 7.2 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2890 PF11081.3 ESS63308.1 - 3.9 7.4 9.5 5.8 6.9 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) CDC45 PF02724.9 ESS63308.1 - 6.4 4.6 7.6 8 4.3 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Ala_racemase_N PF01168.15 ESS63309.1 - 2e-45 154.9 0.0 2.4e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain V_ATPase_I PF01496.14 ESS63311.1 - 4.7e-219 729.0 14.3 2.3e-218 726.7 9.9 1.8 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family TACC PF05010.9 ESS63311.1 - 0.023 14.4 0.3 0.039 13.7 0.2 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) UbiA PF01040.13 ESS63312.1 - 4.5e-29 101.4 16.3 6.2e-29 100.9 11.3 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF2309 PF10070.4 ESS63312.1 - 0.14 10.2 0.0 0.29 9.1 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2309) NRDE-2 PF08424.5 ESS63315.1 - 0.0016 17.3 2.1 0.028 13.3 0.3 3.1 2 1 1 3 3 3 1 NRDE-2, necessary for RNA interference Apc5 PF12862.2 ESS63315.1 - 0.038 13.8 2.0 0.49 10.2 0.0 3.7 5 0 0 5 5 5 0 Anaphase-promoting complex subunit 5 Rifin_STEVOR PF02009.11 ESS63316.1 - 0.022 14.4 0.7 0.034 13.8 0.5 1.3 1 0 0 1 1 1 0 Rifin/stevor family Prenyltransf PF01255.14 ESS63316.1 - 0.022 13.8 0.6 0.032 13.3 0.4 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase Spc7 PF08317.6 ESS63316.1 - 0.037 12.6 3.0 0.055 12.1 2.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3482 PF11981.3 ESS63316.1 - 0.041 13.1 3.7 0.069 12.3 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Mmp37 PF09139.6 ESS63316.1 - 0.15 11.0 0.7 0.21 10.5 0.5 1.1 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 Prenyltransf PF01255.14 ESS63317.1 - 0.046 12.8 0.6 0.074 12.1 0.4 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase Rifin_STEVOR PF02009.11 ESS63317.1 - 0.15 11.7 0.5 0.22 11.1 0.4 1.2 1 0 0 1 1 1 0 Rifin/stevor family HCV_capsid PF01543.12 ESS63317.1 - 0.45 10.5 2.2 0.81 9.6 0.2 2.2 2 1 1 3 3 3 0 Hepatitis C virus capsid protein V-SNARE_C PF12352.3 ESS63320.1 - 3.1e-12 46.3 3.2 3.1e-12 46.3 2.2 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.10 ESS63320.1 - 2.3e-06 27.6 3.2 1.2e-05 25.3 0.0 3.2 2 2 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.8 ESS63320.1 - 3e-06 26.8 2.2 3e-06 26.8 1.5 1.9 2 0 0 2 2 1 1 Sec20 OAD_gamma PF04277.8 ESS63320.1 - 0.0037 17.5 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain IncA PF04156.9 ESS63320.1 - 0.0049 16.4 5.7 1.1 8.8 0.0 3.6 2 1 2 4 4 4 1 IncA protein Sec8_exocyst PF04048.9 ESS63320.1 - 0.009 15.6 1.1 0.02 14.5 0.5 1.7 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain TMP_2 PF06791.8 ESS63320.1 - 0.0093 15.6 1.8 0.016 14.8 1.2 1.3 1 0 0 1 1 1 1 Prophage tail length tape measure protein YukC PF10140.4 ESS63320.1 - 0.012 14.1 0.5 0.019 13.5 0.3 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC MSC PF09402.5 ESS63320.1 - 0.034 12.8 0.1 0.045 12.4 0.0 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Fib_alpha PF08702.5 ESS63320.1 - 0.044 13.9 2.1 3.2 7.8 1.1 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3357 PF11837.3 ESS63320.1 - 0.063 13.1 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF2142 PF09913.4 ESS63320.1 - 0.065 11.9 0.2 0.092 11.3 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) DUF3753 PF12575.3 ESS63320.1 - 0.087 12.6 1.6 0.19 11.5 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) FUSC PF04632.7 ESS63320.1 - 0.098 11.0 0.7 0.15 10.4 0.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF912 PF06024.7 ESS63320.1 - 0.098 12.7 1.4 0.18 11.8 1.0 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Shisa PF13908.1 ESS63320.1 - 0.14 12.3 0.5 0.25 11.4 0.3 1.5 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2383 PF09537.5 ESS63320.1 - 0.14 12.3 5.0 4.4 7.5 0.1 3.2 3 2 0 3 3 2 0 Domain of unknown function (DUF2383) DUF2116 PF09889.4 ESS63320.1 - 0.37 10.6 1.4 0.67 9.7 1.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zf-C4H2 PF10146.4 ESS63320.1 - 0.41 10.6 4.6 0.97 9.4 3.0 1.7 2 0 0 2 2 2 0 Zinc finger-containing protein DUF4140 PF13600.1 ESS63320.1 - 0.47 10.9 4.1 9.2 6.7 0.1 3.1 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Laminin_II PF06009.7 ESS63320.1 - 0.49 10.1 6.6 0.12 12.1 1.5 2.2 2 1 1 3 3 2 0 Laminin Domain II Synaptobrevin PF00957.16 ESS63320.1 - 0.57 9.8 5.7 0.44 10.1 2.3 2.1 1 1 1 2 2 2 0 Synaptobrevin DASH_Duo1 PF08651.5 ESS63320.1 - 2.5 7.7 8.3 0.55 9.8 1.0 2.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 V_ATPase_I PF01496.14 ESS63320.1 - 2.6 5.8 6.4 2 6.2 3.0 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Prefoldin_2 PF01920.15 ESS63320.1 - 8 6.2 9.4 6.7 6.5 3.0 3.2 3 1 0 3 3 3 0 Prefoldin subunit TIP41 PF04176.8 ESS63322.1 - 3e-20 72.2 0.0 5.1e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 TIP41-like family GAF_2 PF13185.1 ESS63322.1 - 3.1e-08 34.2 0.0 6.2e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 GAF domain GAF PF01590.21 ESS63322.1 - 1.3e-07 31.8 0.0 3.2e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.1 ESS63322.1 - 3.8e-05 23.7 0.0 6.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 GAF domain DUF4512 PF14975.1 ESS63323.1 - 0.01 16.6 0.5 0.018 15.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) IgaA PF07095.6 ESS63323.1 - 0.089 10.5 0.1 0.1 10.3 0.1 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA adh_short PF00106.20 ESS63324.1 - 2.8e-22 79.4 1.5 5.5e-22 78.4 0.1 1.8 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ESS63324.1 - 7.1e-08 32.3 0.5 1.3e-07 31.4 0.1 1.6 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 ESS63324.1 - 1.3e-07 31.6 0.2 1.7e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESS63324.1 - 0.00017 21.6 0.2 0.0003 20.8 0.2 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_2 PF03446.10 ESS63324.1 - 0.0048 16.7 0.1 0.13 12.1 0.0 2.3 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Saccharop_dh PF03435.13 ESS63324.1 - 0.015 14.3 0.1 0.024 13.6 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Epimerase PF01370.16 ESS63324.1 - 0.021 14.2 0.2 0.032 13.6 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Thymidylate_kin PF02223.12 ESS63324.1 - 0.041 13.2 0.0 0.085 12.2 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase BNR_3 PF13859.1 ESS63325.1 - 0.1 11.6 0.2 0.1 11.6 0.1 1.2 1 0 0 1 1 1 0 BNR repeat-like domain RHSP PF07999.6 ESS63326.1 - 3.7e-97 325.7 0.9 6.6e-97 324.8 0.6 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS63326.1 - 0.029 14.4 0.1 5.5 7.1 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF3676 PF12429.3 ESS63331.1 - 2.2e-97 325.1 36.8 3.6e-97 324.5 25.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS63331.1 - 2e-81 273.4 0.0 2e-81 273.4 0.0 2.1 2 1 0 2 2 2 1 BNR repeat-like domain Myosin_head PF00063.16 ESS63332.1 - 3.5e-159 531.0 0.1 7.2e-159 530.0 0.0 1.5 1 1 0 1 1 1 1 Myosin head (motor domain) ADK PF00406.17 ESS63334.1 - 4.4e-27 94.8 0.0 6.4e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESS63334.1 - 1.5e-07 32.2 0.0 8.2e-07 29.8 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 ESS63334.1 - 3.9e-06 26.7 0.0 8.4e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 ESS63334.1 - 0.0005 19.4 0.0 0.9 8.8 0.0 3.3 3 0 0 3 3 3 2 Thymidylate kinase AAA_18 PF13238.1 ESS63334.1 - 0.00061 20.0 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 ESS63334.1 - 0.0019 18.0 0.1 0.096 12.5 0.0 2.5 2 1 0 2 2 2 1 Shikimate kinase ADK_lid PF05191.9 ESS63334.1 - 0.099 12.3 0.3 0.21 11.2 0.2 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid RIIa PF02197.12 ESS63334.1 - 0.14 11.6 0.7 0.36 10.3 0.1 2.1 1 1 1 2 2 2 0 Regulatory subunit of type II PKA R-subunit AAA_19 PF13245.1 ESS63334.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain Methyltransf_18 PF12847.2 ESS63335.1 - 9.9e-06 26.1 0.0 1.9e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESS63335.1 - 3.5e-05 23.0 0.5 5.4e-05 22.4 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESS63335.1 - 0.00025 21.0 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 ESS63335.1 - 0.00088 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.9 ESS63335.1 - 0.012 14.9 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.6 ESS63335.1 - 0.013 14.2 0.0 0.019 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.1 ESS63335.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain 2OG-FeII_Oxy_3 PF13640.1 ESS63336.1 - 1.8e-11 44.4 0.0 3.2e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 ESS63336.1 - 2.4e-05 23.8 0.0 4.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.8 ESS63336.1 - 0.0011 17.8 0.0 0.0015 17.3 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein PhyH PF05721.8 ESS63336.1 - 0.0078 16.2 0.0 0.059 13.3 0.0 2.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DEAD PF00270.24 ESS63337.1 - 9.7e-17 60.9 0.0 4.6e-16 58.7 0.0 2.0 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS63337.1 - 1.5e-13 50.3 0.0 3.9e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS63337.1 - 0.032 14.0 0.1 0.19 11.5 0.0 2.3 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit MFS_1 PF07690.11 ESS63339.1 - 2.3e-09 36.4 19.7 3.1e-09 36.0 13.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily AAA PF00004.24 ESS63340.1 - 2.8e-44 150.4 0.0 5.4e-44 149.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS63340.1 - 3.6e-07 29.4 0.0 6.1e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESS63340.1 - 6.4e-05 23.1 0.1 0.026 14.6 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESS63340.1 - 0.0002 21.2 0.0 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESS63340.1 - 0.00024 21.1 0.9 0.017 15.0 0.0 3.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 ESS63340.1 - 0.00099 19.9 0.0 0.0029 18.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS63340.1 - 0.0023 17.6 0.0 0.0074 16.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 ESS63340.1 - 0.0037 17.4 0.0 0.0074 16.4 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Zeta_toxin PF06414.7 ESS63340.1 - 0.0048 16.0 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin IstB_IS21 PF01695.12 ESS63340.1 - 0.0051 16.2 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Vps4_C PF09336.5 ESS63340.1 - 0.0051 16.6 0.1 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_14 PF13173.1 ESS63340.1 - 0.0056 16.5 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS63340.1 - 0.0068 16.2 0.0 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESS63340.1 - 0.015 14.4 0.1 0.028 13.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESS63340.1 - 0.018 13.7 0.0 0.03 13.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_28 PF13521.1 ESS63340.1 - 0.019 14.9 0.0 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 ESS63340.1 - 0.025 13.4 0.0 0.041 12.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 SKI PF01202.17 ESS63340.1 - 0.047 13.5 0.0 0.32 10.8 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase ABC_tran PF00005.22 ESS63340.1 - 0.052 13.8 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.1 ESS63340.1 - 0.058 13.7 0.0 0.18 12.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain DUF815 PF05673.8 ESS63340.1 - 0.06 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.1 ESS63340.1 - 0.077 12.3 0.3 1.2 8.4 0.1 2.5 1 1 1 2 2 2 0 AAA domain PhoH PF02562.11 ESS63340.1 - 0.17 11.0 0.0 0.35 10.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 ESS63340.1 - 0.18 10.9 0.0 0.35 9.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.1 ESS63340.1 - 0.26 10.8 0.1 0.5 9.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Kelch_4 PF13418.1 ESS63342.1 - 2.3e-30 104.0 9.7 4.1e-08 32.8 0.0 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS63342.1 - 4.7e-27 93.4 8.7 1e-07 31.8 0.1 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain DUF4110 PF13422.1 ESS63342.1 - 1.4e-21 76.0 7.9 1.4e-21 76.0 5.5 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4110) Kelch_5 PF13854.1 ESS63342.1 - 1.7e-21 75.7 4.6 0.00028 20.7 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 ESS63342.1 - 2e-19 68.8 9.2 0.0038 17.3 0.0 6.4 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ESS63342.1 - 2.6e-17 62.1 5.2 0.0049 16.3 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESS63342.1 - 2.7e-11 42.7 7.2 0.008 15.9 0.0 5.8 5 0 0 5 5 5 5 Kelch motif GLE1 PF07817.8 ESS63342.1 - 0.079 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 GLE1-like protein Plant_vir_prot PF01307.12 ESS63342.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Plant viral movement protein Nodulin-like PF06813.8 ESS63343.1 - 0.00055 19.2 25.6 0.00058 19.1 14.9 2.7 2 1 0 2 2 2 1 Nodulin-like DUF3357 PF11837.3 ESS63343.1 - 0.46 10.3 7.1 5.1 6.9 0.7 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF3357) DUF1738 PF08401.6 ESS63345.1 - 2.2e-05 24.2 0.0 0.17 11.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF1738) MORN PF02493.15 ESS63346.1 - 0.00042 19.8 1.4 0.022 14.4 0.0 3.3 4 0 0 4 4 4 2 MORN repeat APH PF01636.18 ESS63348.1 - 1.6e-18 67.3 0.0 4.4e-18 65.8 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family HAD_2 PF13419.1 ESS63348.1 - 9.7e-05 22.6 0.2 0.071 13.3 0.0 3.1 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase UPF0081 PF03652.10 ESS63349.1 - 0.081 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0081) DUF4490 PF14892.1 ESS63350.1 - 0.04 13.5 1.1 0.13 11.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4490) BNR_3 PF13859.1 ESS63353.1 - 1.5e-83 280.4 1.7 2.1e-83 279.9 1.2 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF2909 PF11137.3 ESS63353.1 - 0.073 12.8 0.1 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) BNR_3 PF13859.1 ESS63354.1 - 5e-30 104.6 0.2 7.9e-30 103.9 0.2 1.3 1 0 0 1 1 1 1 BNR repeat-like domain MIP-T3 PF10243.4 ESS63355.1 - 1.2 7.4 12.2 1.7 7.0 8.5 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Nucleoplasmin PF03066.10 ESS63358.1 - 0.36 10.3 8.8 0.87 9.0 6.1 1.6 1 0 0 1 1 1 0 Nucleoplasmin FRG2 PF15315.1 ESS63358.1 - 3.1 7.7 16.0 4 7.3 0.6 2.3 2 0 0 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 SseC PF04888.7 ESS63361.1 - 0.11 11.8 19.5 0.14 11.4 13.5 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Mucin PF01456.12 ESS63362.1 - 0.0041 16.9 13.0 0.0099 15.6 9.0 1.8 1 1 0 1 1 1 1 Mucin-like glycoprotein Antibiotic_NAT PF02522.9 ESS63365.1 - 0.068 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase RHSP PF07999.6 ESS63366.1 - 1e-66 225.3 0.0 1.2e-66 225.1 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein BNR_3 PF13859.1 ESS63368.1 - 4.5e-30 104.7 0.4 1e-29 103.5 0.1 1.8 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63368.1 - 3.6e-17 63.0 0.5 7.3e-17 62.0 0.4 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63368.1 - 2.6e-12 46.3 12.2 4.8e-12 45.5 8.5 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63369.1 - 1.4e-77 260.8 3.4 1.9e-77 260.4 2.4 1.2 1 0 0 1 1 1 1 BNR repeat-like domain RHSP PF07999.6 ESS63371.1 - 3.9e-81 272.8 0.0 5.7e-81 272.3 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS63371.1 - 0.089 12.9 0.2 8 6.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain Phage_integrase PF00589.17 ESS63372.1 - 0.013 15.2 0.1 0.028 14.1 0.1 1.7 1 1 0 1 1 1 0 Phage integrase family DUF4407 PF14362.1 ESS63373.1 - 0.037 13.0 6.0 0.064 12.2 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Preseq_ALAS PF09029.5 ESS63377.1 - 4.6 7.2 6.8 0.45 10.5 1.3 1.9 3 0 0 3 3 3 0 5-aminolevulinate synthase presequence Kelch_5 PF13854.1 ESS63378.1 - 2.4e-11 43.3 1.3 0.00013 21.8 0.2 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 ESS63378.1 - 3.7e-10 39.4 6.2 3.6e-06 26.6 0.1 3.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESS63378.1 - 3.2e-08 33.3 0.4 0.012 15.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 ESS63378.1 - 4.8e-05 22.8 4.6 0.059 12.9 0.1 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESS63378.1 - 0.00012 22.1 7.8 0.093 12.9 0.4 5.1 4 1 1 5 5 5 1 Galactose oxidase, central domain Potassium_chann PF11404.3 ESS63378.1 - 0.02 14.6 0.3 0.04 13.6 0.2 1.5 1 0 0 1 1 1 0 Potassium voltage-gated channel Kelch_4 PF13418.1 ESS63379.1 - 1.1e-08 34.6 0.6 0.00063 19.4 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS63379.1 - 3.5e-05 23.8 10.8 7.9e-05 22.7 0.0 4.2 3 2 1 4 4 4 1 Galactose oxidase, central domain RestrictionMunI PF11407.3 ESS63382.1 - 0.18 11.4 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II restriction enzyme MunI DUF3584 PF12128.3 ESS63383.1 - 0.025 11.9 18.5 0.041 11.2 12.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TBPIP PF07106.8 ESS63383.1 - 0.54 9.7 12.8 1 8.8 8.8 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Atg14 PF10186.4 ESS63383.1 - 0.59 9.0 11.6 1.9 7.3 8.1 1.9 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 ESS63383.1 - 8.1 5.9 27.3 22 4.5 17.7 2.5 2 1 1 3 3 3 0 IncA protein AAA PF00004.24 ESS63389.1 - 3e-38 131.0 0.0 6.8e-38 129.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS63389.1 - 2.3e-06 27.7 0.1 0.00014 22.0 0.1 2.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS63389.1 - 3.4e-06 26.8 0.1 3.4e-05 23.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESS63389.1 - 2e-05 23.7 0.0 3.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Vps4_C PF09336.5 ESS63389.1 - 4.1e-05 23.3 0.0 9.7e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_17 PF13207.1 ESS63389.1 - 0.00025 21.8 0.0 0.0007 20.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS63389.1 - 0.00027 20.6 0.0 0.0021 17.7 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain TIP49 PF06068.8 ESS63389.1 - 0.0004 19.2 0.0 0.001 17.8 0.0 1.6 1 1 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESS63389.1 - 0.0012 18.2 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 ESS63389.1 - 0.0024 17.8 0.9 0.013 15.5 0.0 2.5 2 2 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.9 ESS63389.1 - 0.0027 17.6 0.0 0.0052 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 ESS63389.1 - 0.004 16.3 0.1 0.01 15.0 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 ESS63389.1 - 0.0064 15.6 0.0 0.014 14.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 ESS63389.1 - 0.0066 16.3 0.3 0.022 14.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESS63389.1 - 0.014 14.8 1.3 0.22 10.8 0.0 2.8 2 1 0 3 3 3 0 AAA domain AAA_14 PF13173.1 ESS63389.1 - 0.024 14.5 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESS63389.1 - 0.027 14.0 0.2 0.076 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 ESS63389.1 - 0.047 12.6 0.0 0.094 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.1 ESS63389.1 - 0.065 13.5 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESS63389.1 - 0.066 12.6 0.0 0.95 8.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 ESS63389.1 - 0.076 11.8 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.17 ESS63389.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.1 ESS63389.1 - 0.15 12.0 1.7 0.24 11.3 0.0 2.2 3 0 0 3 3 3 0 AAA domain Rad21_Rec8_N PF04825.8 ESS63396.1 - 1.8e-32 111.5 0.0 4.6e-32 110.2 0.0 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 ESS63396.1 - 8e-08 31.3 0.0 6.3e-07 28.4 0.0 2.3 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 ESS63396.1 - 0.0013 18.3 3.2 0.0028 17.2 0.1 2.6 3 1 0 3 3 3 1 ScpA/B protein MORN PF02493.15 ESS63397.1 - 1.6e-26 90.4 35.0 1.1e-06 28.0 1.6 7.8 8 0 0 8 8 8 6 MORN repeat VID27 PF08553.5 ESS63397.1 - 1.4 7.0 6.1 2.1 6.4 4.3 1.2 1 0 0 1 1 1 0 VID27 cytoplasmic protein DNA_repr_REX1B PF14966.1 ESS63398.1 - 2.9 8.3 9.6 0.71 10.2 3.1 2.5 3 0 0 3 3 3 0 DNA repair REX1-B Lectin_leg-like PF03388.8 ESS63400.1 - 3.4e-12 45.9 0.5 0.00013 21.2 0.0 3.9 4 2 1 5 5 5 2 Legume-like lectin family PBP1_TM PF14812.1 ESS63400.1 - 0.034 14.4 11.9 0.14 12.4 8.2 2.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Suppressor_P21 PF11479.3 ESS63400.1 - 0.056 13.1 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 RNA silencing suppressor P21 CDC45 PF02724.9 ESS63400.1 - 0.48 8.3 11.3 0.79 7.6 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.10 ESS63400.1 - 0.94 8.9 12.3 1.7 8.1 8.5 1.3 1 0 0 1 1 1 0 Nucleoplasmin Myc_N PF01056.13 ESS63400.1 - 2 7.4 11.7 0.16 11.1 4.4 1.7 2 0 0 2 2 2 0 Myc amino-terminal region Tom37_C PF11801.3 ESS63400.1 - 2.2 8.1 4.3 6.6 6.5 3.0 1.7 1 0 0 1 1 1 0 Tom37 C-terminal domain FAM176 PF14851.1 ESS63400.1 - 9.6 5.8 9.2 13 5.4 4.0 2.4 2 0 0 2 2 2 0 FAM176 family AFG1_ATPase PF03969.11 ESS63401.1 - 8.7e-84 281.3 1.0 2.1e-77 260.4 0.0 2.9 2 1 0 3 3 3 2 AFG1-like ATPase Bac_DnaA PF00308.13 ESS63401.1 - 2.2e-07 30.7 0.2 2.1e-06 27.5 0.1 2.2 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_22 PF13401.1 ESS63401.1 - 0.00056 20.0 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESS63401.1 - 0.016 15.4 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS63401.1 - 0.031 14.2 0.0 0.077 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 ESS63401.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.1 ESS63401.1 - 0.058 13.2 0.1 0.25 11.2 0.1 2.1 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESS63401.1 - 0.061 13.0 0.0 0.39 10.3 0.0 2.2 3 0 0 3 3 3 0 Archaeal ATPase DUF123 PF01986.11 ESS63401.1 - 0.069 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF123 RNA_helicase PF00910.17 ESS63401.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Peptidase_M28 PF04389.12 ESS63402.1 - 1.9e-24 86.3 0.3 5e-07 29.6 0.0 3.2 3 0 0 3 3 3 3 Peptidase family M28 Med13_N PF11597.3 ESS63402.1 - 0.11 11.2 0.0 0.2 10.3 0.0 1.4 2 0 0 2 2 2 0 Mediator complex subunit 13 N-terminal LON PF02190.11 ESS63403.1 - 0.00069 19.3 0.3 0.0041 16.8 0.0 2.2 3 0 0 3 3 3 1 ATP-dependent protease La (LON) domain Spc7 PF08317.6 ESS63403.1 - 0.0033 16.1 9.3 0.0033 16.1 6.4 2.2 3 0 0 3 3 3 1 Spc7 kinetochore protein IL15 PF02372.10 ESS63403.1 - 2.3 8.0 9.1 0.81 9.4 3.5 2.2 2 0 0 2 2 2 0 Interleukin 15 UQ_con PF00179.21 ESS63404.1 - 2.8e-21 75.4 0.0 4.6e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESS63404.1 - 0.085 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 RWD domain Flagellar_rod PF05149.7 ESS63405.1 - 6.3e-105 350.4 32.3 1.6e-104 349.1 22.4 1.6 1 0 0 1 1 1 1 Paraflagellar rod protein Cyclase_polyket PF04673.7 ESS63405.1 - 0.29 11.1 2.5 4.7 7.3 0.3 3.0 2 0 0 2 2 2 0 Polyketide synthesis cyclase Herpes_capsid PF06112.6 ESS63406.1 - 0.0016 18.4 4.8 0.0036 17.3 3.3 1.5 1 0 0 1 1 1 1 Gammaherpesvirus capsid protein CPSF_A PF03178.10 ESS63407.1 - 6.9e-17 61.5 0.0 1e-15 57.6 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.4 ESS63407.1 - 8.3e-15 53.9 0.0 4.8e-05 21.6 0.0 3.4 3 0 0 3 3 3 3 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF3619 PF12279.3 ESS63407.1 - 0.048 13.7 2.5 3.5 7.7 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Imm24 PF15570.1 ESS63409.1 - 0.0071 16.0 0.9 0.0087 15.7 0.6 1.2 1 0 0 1 1 1 1 Immunity protein 24 zf-C2HC_2 PF13913.1 ESS63410.1 - 2.2e-15 55.8 8.2 3.5e-07 29.6 2.0 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2 PF00096.21 ESS63410.1 - 0.016 15.5 1.5 4.8 7.7 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS63410.1 - 0.066 13.5 2.6 6.4 7.3 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESS63410.1 - 0.14 12.1 0.3 10 6.1 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-RING_3 PF14369.1 ESS63410.1 - 0.52 10.3 2.6 1.3 9.0 0.1 2.4 2 0 0 2 2 2 0 zinc-finger zf-Di19 PF05605.7 ESS63410.1 - 0.68 10.0 2.6 1.5 9.0 0.4 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 ESS63410.1 - 0.87 10.0 4.3 2.4 8.6 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double domain Sgf11 PF08209.6 ESS63410.1 - 1.4 8.2 8.2 2.2 7.6 0.9 2.6 2 1 0 2 2 2 0 Sgf11 (transcriptional regulation protein) APC_CDC26 PF10471.4 ESS63410.1 - 4.4 8.1 31.3 0.53 11.0 0.5 4.4 4 0 0 4 4 4 0 Anaphase-promoting complex APC subunit 1 zf-MYND PF01753.13 ESS63413.1 - 1.1e-10 41.1 8.4 2e-10 40.3 5.8 1.4 1 0 0 1 1 1 1 MYND finger MAM33 PF02330.11 ESS63414.1 - 2e-08 34.2 0.0 2.8e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein TTL PF03133.10 ESS63415.1 - 7.7e-70 235.1 0.0 1e-69 234.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ESS63415.1 - 0.0009 18.1 0.0 0.0082 14.9 0.0 2.1 2 0 0 2 2 2 1 YheC/D like ATP-grasp MCM PF00493.18 ESS63416.1 - 5.5e-82 275.2 0.0 1.1e-81 274.2 0.0 1.5 1 0 0 1 1 1 1 MCM2/3/5 family Pkinase PF00069.20 ESS63416.1 - 1.5e-52 178.3 0.0 2.3e-52 177.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63416.1 - 1e-36 126.3 0.0 1.6e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 ESS63416.1 - 2.2e-09 37.4 0.0 4.7e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 PH domain Mg_chelatase PF01078.16 ESS63416.1 - 1.2e-07 31.1 0.2 1.7e-05 24.0 0.0 2.6 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESS63416.1 - 1.2e-07 31.4 0.0 2.5e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Kinase-like PF14531.1 ESS63416.1 - 3.9e-07 29.3 0.0 8.8e-07 28.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Sigma54_activat PF00158.21 ESS63416.1 - 0.022 14.2 0.0 0.57 9.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.6 ESS63416.1 - 0.048 13.2 0.0 0.17 11.5 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad51 PF08423.6 ESS63419.1 - 5.5e-134 444.9 0.1 7.9e-134 444.4 0.1 1.2 1 0 0 1 1 1 1 Rad51 RecA PF00154.16 ESS63419.1 - 3.3e-12 46.1 0.2 4.5e-12 45.6 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.1 ESS63419.1 - 8.4e-11 41.6 0.0 1.4e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ESS63419.1 - 1.9e-07 30.4 0.0 4e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 KaiC HHH_5 PF14520.1 ESS63419.1 - 5.1e-07 29.7 0.6 1.3e-06 28.5 0.5 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DnaB_C PF03796.10 ESS63419.1 - 0.023 13.5 0.1 0.046 12.6 0.1 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DUF1664 PF07889.7 ESS63420.1 - 0.016 15.0 0.8 0.016 15.0 0.5 9.4 2 2 7 11 11 11 0 Protein of unknown function (DUF1664) Filament PF00038.16 ESS63420.1 - 0.064 12.7 180.0 0.024 14.1 37.3 4.8 1 1 3 4 4 4 0 Intermediate filament protein Baculo_PEP_C PF04513.7 ESS63420.1 - 3.4 7.4 55.6 0.27 11.0 2.2 9.1 6 3 3 9 9 9 0 Baculovirus polyhedron envelope protein, PEP, C terminus Neocarzinostat PF00960.13 ESS63421.1 - 0.12 12.3 0.2 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 Neocarzinostatin family DUF2267 PF10025.4 ESS63422.1 - 0.17 11.9 2.4 0.17 11.9 0.1 2.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) Phage_fiber PF03335.8 ESS63422.1 - 0.21 11.3 0.7 0.57 10.0 0.5 1.7 1 0 0 1 1 1 0 Phage tail fibre repeat His_Phos_1 PF00300.17 ESS63423.1 - 3.4e-12 46.7 0.0 5.3e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) BRCT PF00533.21 ESS63424.1 - 4.7e-05 23.4 0.0 0.049 13.7 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain EthD PF07110.6 ESS63424.1 - 0.032 15.1 0.0 0.061 14.2 0.0 1.5 1 0 0 1 1 1 0 EthD domain DZR PF12773.2 ESS63424.1 - 0.08 12.7 1.7 0.26 11.1 1.1 1.8 1 0 0 1 1 1 0 Double zinc ribbon A_deaminase PF00962.17 ESS63425.1 - 1.4e-102 343.0 0.0 4e-78 262.6 0.0 2.5 2 0 0 2 2 2 2 Adenosine/AMP deaminase IncA PF04156.9 ESS63425.1 - 4.4 6.8 7.3 8.7 5.8 5.1 1.4 1 0 0 1 1 1 0 IncA protein Pro_isomerase PF00160.16 ESS63426.1 - 2.9e-44 151.0 0.1 4.9e-44 150.2 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 ESS63426.1 - 4.2e-22 77.5 8.3 8.2e-12 44.6 0.3 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS63426.1 - 4.3e-16 57.4 1.2 1.6e-05 24.4 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS63426.1 - 1.2e-14 53.1 2.2 1.1e-05 24.7 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63426.1 - 7.8e-07 28.9 4.9 0.0004 20.2 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63426.1 - 2e-06 27.9 0.2 0.081 13.5 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS63426.1 - 6.4e-06 26.6 3.1 3.5e-05 24.3 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63426.1 - 6.8e-06 25.4 0.6 0.065 13.0 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63426.1 - 6.6e-05 22.7 0.3 0.055 13.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63426.1 - 0.00011 22.4 1.1 0.91 10.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS63426.1 - 0.00022 21.4 1.6 0.041 14.2 0.1 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS63426.1 - 0.00025 20.8 0.1 0.00059 19.6 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS63426.1 - 0.00041 20.4 0.9 0.034 14.2 0.4 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.2 ESS63426.1 - 0.0018 18.1 3.2 0.0021 17.9 0.7 2.1 2 1 0 2 2 1 1 Domain of Unknown Function (DUF3856) Fis1_TPR_C PF14853.1 ESS63426.1 - 0.043 13.6 0.5 0.53 10.2 0.1 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 ESS63426.1 - 0.076 12.8 2.6 2.9 7.9 0.0 3.4 3 1 1 4 4 3 0 Tetratricopeptide repeat Vel1p PF10339.4 ESS63426.1 - 0.08 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Yeast-specific zinc responsive MecA_N PF05223.6 ESS63426.1 - 0.16 12.0 3.7 1.7 8.7 0.2 2.2 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain Gp_dh_N PF00044.19 ESS63428.1 - 8.1e-29 100.5 0.0 1.4e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Gp_dh_C PF02800.15 ESS63428.1 - 8.6e-25 87.0 0.0 1.1e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain ADH_zinc_N PF00107.21 ESS63428.1 - 0.031 13.8 0.1 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RCC1 PF00415.13 ESS63429.1 - 3.4e-41 139.2 17.6 3e-12 46.5 0.1 6.9 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS63429.1 - 1.6e-34 116.7 33.1 1.7e-10 40.1 0.5 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat CBM_X PF06204.6 ESS63429.1 - 9.3 5.8 6.3 8.7 5.9 0.1 3.1 4 0 0 4 4 4 0 Putative carbohydrate binding domain HSP70 PF00012.15 ESS63430.1 - 4e-76 256.2 5.9 1.9e-75 254.0 4.1 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESS63430.1 - 8.1e-05 21.3 0.1 0.00091 17.9 0.0 2.4 3 0 0 3 3 3 1 MreB/Mbl protein FGGY_C PF02782.11 ESS63430.1 - 0.015 14.9 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Kinesin PF00225.18 ESS63431.1 - 2e-61 207.5 0.0 3.3e-61 206.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain AAA_16 PF13191.1 ESS63431.1 - 0.00031 20.7 0.0 0.00068 19.6 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF3197 PF11432.3 ESS63431.1 - 0.039 13.9 0.0 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3197) AAA_22 PF13401.1 ESS63431.1 - 0.04 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESS63431.1 - 0.047 13.4 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF87 Laminin_G_3 PF13385.1 ESS63432.1 - 1.3e-18 67.7 1.7 2.5e-18 66.7 1.2 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63432.1 - 1.7e-12 46.9 9.0 3.9e-12 45.7 6.2 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF2616 PF11077.3 ESS63433.1 - 0.011 15.2 0.5 0.016 14.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) DUF3742 PF12553.3 ESS63435.1 - 1.7 9.1 0.0 1.7 9.1 0.0 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF3742) GAGA_bind PF06217.7 ESS63438.1 - 0.041 13.8 0.5 0.053 13.4 0.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RVT_1 PF00078.22 ESS63440.1 - 0.086 12.1 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.21 ESS63442.1 - 0.0062 16.8 3.6 0.089 13.1 0.2 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS63442.1 - 0.028 14.7 8.5 0.084 13.2 0.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Mucin PF01456.12 ESS63444.1 - 6.3e-37 126.5 46.8 5.5e-23 81.3 13.5 2.4 1 1 1 2 2 2 2 Mucin-like glycoprotein LMBR1 PF04791.11 ESS63444.1 - 0.091 11.3 1.7 0.48 8.9 1.2 1.9 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF4658 PF15555.1 ESS63444.1 - 1.2 8.9 4.3 1.2 9.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) BNR_3 PF13859.1 ESS63446.1 - 8.3e-130 432.3 5.8 1.5e-129 431.5 4.1 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63446.1 - 3.5e-16 59.8 1.9 3.7e-16 59.7 0.3 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63446.1 - 5.3e-06 26.2 7.0 1.2e-05 25.1 4.8 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS63449.1 - 4.5e-05 23.7 0.0 6.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PEGA PF08308.6 ESS63449.1 - 0.093 12.5 0.0 0.72 9.6 0.0 2.2 2 0 0 2 2 2 0 PEGA domain BNR_3 PF13859.1 ESS63450.1 - 5.5e-101 337.7 3.3 1.3e-100 336.4 2.3 1.7 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63450.1 - 1.2e-18 67.8 0.6 3.4e-18 66.3 0.4 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63450.1 - 3.7e-06 26.6 10.3 8.8e-06 25.4 7.1 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR PF02012.15 ESS63450.1 - 0.71 9.9 9.4 6.7 6.9 0.0 4.9 4 0 0 4 4 4 0 BNR/Asp-box repeat BNR_3 PF13859.1 ESS63451.1 - 9e-22 77.5 0.1 1.4e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain DUF4534 PF15049.1 ESS63454.1 - 0.086 12.4 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4534) Thiolase_C PF02803.13 ESS63460.1 - 1.2e-12 47.2 0.4 3.1e-11 42.7 0.1 2.7 2 1 1 3 3 3 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 ESS63460.1 - 5.2e-09 35.4 0.2 1.3e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 ESS63460.1 - 5e-07 29.4 2.3 2.1e-06 27.3 0.3 2.6 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 ESS63460.1 - 0.022 14.3 3.2 0.91 9.2 0.4 3.1 3 1 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Aa_trans PF01490.13 ESS63461.1 - 1.2e-55 188.7 34.1 1.4e-55 188.4 23.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS63461.1 - 8.4e-07 28.1 10.0 8.4e-07 28.1 6.9 2.0 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Sigma_reg_N PF13800.1 ESS63461.1 - 4.4 7.3 8.1 11 6.0 0.1 3.4 2 1 1 3 3 3 0 Sigma factor regulator N-terminal RRM_1 PF00076.17 ESS63462.1 - 6.5e-12 44.9 0.0 9.7e-12 44.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS63462.1 - 3.9e-11 42.7 0.0 6.1e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS63462.1 - 2.3e-07 30.5 0.0 3.5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RIH_assoc PF08454.6 ESS63463.1 - 4.1e-31 106.8 0.4 1.8e-30 104.8 0.1 2.2 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.26 ESS63463.1 - 7.9e-09 35.0 11.2 7.9e-09 35.0 7.8 3.0 2 1 0 2 2 2 2 Ion transport protein Ins145_P3_rec PF08709.6 ESS63464.1 - 3.3e-55 186.4 0.0 1.2e-54 184.5 0.0 2.0 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESS63464.1 - 0.012 15.1 0.0 0.04 13.4 0.0 2.0 1 1 1 2 2 2 0 MIR domain MMR_HSR1 PF01926.18 ESS63465.1 - 3e-12 46.5 0.0 5.2e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESS63465.1 - 6.7e-07 29.2 0.0 4.6e-05 23.3 0.1 2.5 1 1 1 2 2 2 1 Dynamin family DUF258 PF03193.11 ESS63465.1 - 2.4e-05 23.5 0.0 5.3e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESS63465.1 - 0.00082 18.8 0.0 0.0018 17.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ESS63465.1 - 0.001 18.5 0.0 2.9 7.2 0.0 3.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESS63465.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.22 ESS63465.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 ESS63465.1 - 0.013 15.8 0.2 0.029 14.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESS63465.1 - 0.017 14.8 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Parvo_NS1 PF01057.12 ESS63465.1 - 0.038 12.8 0.0 1 8.1 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Gtr1_RagA PF04670.7 ESS63465.1 - 0.047 12.8 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF1738 PF08401.6 ESS63466.1 - 0.0093 15.6 0.0 0.029 14.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1738) DUF1738 PF08401.6 ESS63467.1 - 0.00021 21.0 0.4 0.032 13.9 0.1 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF1738) DUF676 PF05057.9 ESS63469.1 - 0.097 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) SET PF00856.23 ESS63470.1 - 1.6e-11 44.7 0.5 1.4e-07 31.9 0.5 2.7 2 1 0 2 2 2 2 SET domain zf-Mss51 PF13824.1 ESS63470.1 - 0.00037 20.2 1.8 0.0021 17.8 1.2 2.3 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.13 ESS63470.1 - 0.00098 18.9 3.9 0.00098 18.9 2.7 3.1 3 0 0 3 3 3 1 MYND finger FAD-oxidase_C PF02913.14 ESS63471.1 - 8.6e-43 146.4 0.0 1.4e-42 145.7 0.0 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 ESS63471.1 - 6.1e-34 116.4 0.7 4.6e-33 113.6 0.7 2.2 2 0 0 2 2 2 1 FAD binding domain Chaperone_III PF07824.7 ESS63471.1 - 0.056 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Type III secretion chaperone domain SET PF00856.23 ESS63472.1 - 3.7e-12 46.8 0.0 3.9e-11 43.5 0.0 2.2 2 1 0 2 2 2 1 SET domain DUF2321 PF10083.4 ESS63472.1 - 0.078 12.4 0.5 0.14 11.6 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Na_H_Exchanger PF00999.16 ESS63474.1 - 7.1e-44 149.8 44.7 1e-43 149.3 31.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF726 PF05277.7 ESS63474.1 - 0.00051 19.0 0.2 0.00096 18.1 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF726) TPR_19 PF14559.1 ESS63475.1 - 9.2e-06 25.9 0.5 0.0076 16.5 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63475.1 - 0.019 14.7 1.3 0.2 11.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63475.1 - 0.026 15.1 1.4 13 6.7 0.0 3.9 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63475.1 - 0.24 11.7 1.2 2.2 8.7 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_28 PF02636.12 ESS63476.1 - 1.7e-58 197.9 0.0 2.3e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase tRNA-synt_1 PF00133.17 ESS63479.1 - 8.4e-31 106.6 0.0 2.2e-18 65.6 0.0 3.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESS63479.1 - 1.2e-19 70.3 0.0 7.2e-10 38.0 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 ESS63479.1 - 2.2e-11 43.7 0.0 5e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 ESS63479.1 - 7.4e-06 25.2 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain zf-RING_2 PF13639.1 ESS63480.1 - 1.1e-09 37.9 13.0 2.6e-09 36.7 9.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS63480.1 - 3e-05 23.9 12.4 3e-05 23.9 8.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS63480.1 - 4.1e-05 23.1 9.0 4.1e-05 23.1 6.2 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESS63480.1 - 0.0064 16.5 8.4 0.016 15.2 5.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESS63480.1 - 0.093 12.4 13.9 0.12 12.0 7.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS63480.1 - 0.56 9.9 15.7 0.082 12.6 8.1 1.7 2 0 0 2 2 2 0 zinc-RING finger domain PQQ_2 PF13360.1 ESS63481.1 - 1.8e-29 102.9 7.7 1.9e-05 24.2 0.0 8.1 7 2 0 7 7 7 5 PQQ-like domain PQQ PF01011.16 ESS63481.1 - 9.3e-07 28.0 7.8 0.048 13.2 0.0 8.0 8 0 0 8 8 8 1 PQQ enzyme repeat PQQ_3 PF13570.1 ESS63481.1 - 6.7e-06 26.2 10.0 16 5.9 0.0 9.9 9 0 0 9 9 9 1 PQQ-like domain DUF4604 PF15377.1 ESS63483.1 - 3.3 7.8 12.0 4.8 7.3 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF155 PF02582.9 ESS63484.1 - 2e-38 132.0 0.0 3e-38 131.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Abhydrolase_6 PF12697.2 ESS63485.1 - 7.5e-19 68.5 1.5 1.8e-17 64.0 1.1 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS63485.1 - 2.6e-09 36.9 0.0 5.5e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS63485.1 - 7.1e-06 25.7 0.0 0.0099 15.4 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold PGAP1 PF07819.8 ESS63485.1 - 0.0015 18.1 0.2 0.0039 16.7 0.1 1.8 1 1 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.15 ESS63485.1 - 0.013 15.6 0.3 0.23 11.6 0.0 2.4 2 1 0 2 2 2 0 Thioesterase domain Abhydro_lipase PF04083.11 ESS63485.1 - 0.032 13.6 0.0 0.091 12.1 0.0 1.8 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region LCAT PF02450.10 ESS63485.1 - 0.046 12.6 0.0 0.074 12.0 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF676 PF05057.9 ESS63485.1 - 0.085 12.1 0.2 0.23 10.7 0.1 1.6 1 1 0 1 1 1 0 Putative serine esterase (DUF676) MAM33 PF02330.11 ESS63486.1 - 0.0014 18.4 1.2 0.009 15.7 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial glycoprotein Securin PF04856.8 ESS63486.1 - 0.051 13.2 0.2 0.09 12.4 0.1 1.4 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor Adenylsucc_synt PF00709.16 ESS63487.1 - 1.2e-110 370.0 0.0 1.5e-110 369.7 0.0 1.1 1 0 0 1 1 1 1 Adenylosuccinate synthetase Nucleoside_tran PF01733.13 ESS63488.1 - 8.2e-27 94.1 3.8 8.2e-27 94.1 2.6 1.8 1 1 0 1 1 1 1 Nucleoside transporter TPK_B1_binding PF04265.9 ESS63490.1 - 2.6e-17 62.2 0.0 4.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.11 ESS63490.1 - 2.4e-07 30.3 0.0 0.0075 15.8 0.0 3.2 3 0 0 3 3 3 2 Thiamin pyrophosphokinase, catalytic domain DUF4218 PF13960.1 ESS63490.1 - 0.097 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Peptidase_M1 PF01433.15 ESS63491.1 - 4.9e-126 420.9 0.2 7.3e-126 420.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 ESS63491.1 - 2e-45 155.4 4.2 2.5e-45 155.1 2.3 1.6 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 ESS63491.1 - 1.7e-19 70.1 0.5 4.3e-19 68.8 0.4 1.7 1 0 0 1 1 1 1 Peptidase MA superfamily Endonuclease_NS PF01223.18 ESS63492.1 - 2.9e-19 69.5 0.0 5.3e-19 68.6 0.0 1.4 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease IFT57 PF10498.4 ESS63493.1 - 0.083 11.6 1.4 0.14 10.8 1.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Abhydro_lipase PF04083.11 ESS63494.1 - 0.96 8.8 3.4 19 4.6 0.2 2.7 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Ribosomal_60s PF00428.14 ESS63499.1 - 0.031 14.6 17.8 0.043 14.2 12.4 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein BNR_3 PF13859.1 ESS63505.1 - 6.4e-107 357.1 4.0 6.4e-107 357.1 2.8 1.7 2 0 0 2 2 2 1 BNR repeat-like domain ETRAMP PF09716.5 ESS63506.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF1284 PF06935.6 ESS63506.1 - 0.18 12.0 0.8 0.27 11.4 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1284) Exo_endo_phos_2 PF14529.1 ESS63509.1 - 1.1e-17 63.7 0.0 1.8e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS63509.1 - 5.7e-13 49.3 0.0 8.4e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 ESS63510.1 - 3.5e-35 119.0 22.8 3.4e-10 39.2 0.2 6.5 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS63510.1 - 3e-18 65.2 24.8 3.9e-07 29.7 1.8 6.2 4 3 2 6 6 6 5 Leucine rich repeat LRR_1 PF00560.28 ESS63510.1 - 9.1e-15 52.4 25.3 0.19 11.8 0.3 10.1 10 0 0 10 10 10 5 Leucine Rich Repeat LRR_9 PF14580.1 ESS63510.1 - 1e-13 51.2 6.3 0.00053 19.5 0.0 4.3 1 1 3 4 4 4 3 Leucine-rich repeat LRR_7 PF13504.1 ESS63510.1 - 1e-09 37.0 16.3 0.67 10.4 0.1 8.4 9 0 0 9 9 9 3 Leucine rich repeat LRR_6 PF13516.1 ESS63510.1 - 1.1e-08 34.1 17.0 0.042 13.9 0.2 9.1 7 3 2 9 9 9 2 Leucine Rich repeat DUF310 PF03750.8 ESS63510.1 - 0.0071 16.5 0.1 0.076 13.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF310) NDUFA12 PF05071.11 ESS63513.1 - 0.73 10.3 9.3 0.049 14.1 1.8 2.6 2 1 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Histone_HNS PF00816.16 ESS63513.1 - 0.8 10.2 13.8 5.7 7.5 4.1 2.7 2 0 0 2 2 2 0 H-NS histone family DUF2215 PF10225.4 ESS63513.1 - 1.5 8.1 6.2 0.68 9.3 0.8 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) Mid2 PF04478.7 ESS63514.1 - 0.00022 20.6 1.0 0.0004 19.8 0.0 1.9 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor vATP-synt_AC39 PF01992.11 ESS63515.1 - 9.6e-60 202.4 0.0 1.1e-59 202.2 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Band_7 PF01145.20 ESS63517.1 - 3.1e-27 95.6 0.1 3.1e-27 95.6 0.1 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 ESS63517.1 - 0.035 13.6 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Acetyltransf_2 PF00797.12 ESS63518.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 N-acetyltransferase UPF0020 PF01170.13 ESS63519.1 - 1.5e-15 57.1 0.1 5.7e-11 42.3 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 ESS63519.1 - 1.3e-11 44.5 0.8 3.2e-11 43.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain N6_N4_Mtase PF01555.13 ESS63519.1 - 3.5e-05 23.4 0.0 0.0015 18.0 0.0 2.2 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.11 ESS63519.1 - 0.0012 18.0 0.0 0.016 14.3 0.0 2.0 2 0 0 2 2 2 1 N-6 DNA Methylase Cons_hypoth95 PF03602.10 ESS63519.1 - 0.025 13.9 0.0 3 7.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical protein 95 DsbD_2 PF13386.1 ESS63519.1 - 0.039 13.6 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region MFS_1 PF07690.11 ESS63520.1 - 3.1e-34 118.2 30.7 1.2e-33 116.2 21.4 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.1 ESS63520.1 - 0.044 13.2 18.0 1 8.7 3.3 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) Complex1_51K PF01512.12 ESS63521.1 - 6.2e-45 152.6 0.0 1.1e-44 151.7 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 ESS63521.1 - 2.7e-18 64.8 0.2 5.4e-18 63.8 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 ESS63521.1 - 1.9e-08 34.0 0.0 3.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 SLBB domain zf-C3HC4_3 PF13920.1 ESS63523.1 - 0.0003 20.4 6.5 0.0004 19.9 4.5 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C2HC5 PF06221.8 ESS63523.1 - 0.0091 15.7 2.7 0.0091 15.7 1.8 1.7 1 1 1 2 2 2 1 Putative zinc finger motif, C2HC5-type zf-RING_5 PF14634.1 ESS63523.1 - 0.034 13.8 7.3 0.05 13.3 5.0 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESS63523.1 - 1 9.4 8.5 2.8 8.0 5.9 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS63523.1 - 2.2 8.1 11.8 8.1 6.3 8.2 1.8 1 1 0 1 1 1 0 Ring finger domain FANCL_C PF11793.3 ESS63523.1 - 2.4 8.2 8.2 4.6 7.2 0.2 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain TerY-C PF15616.1 ESS63523.1 - 2.9 7.8 7.1 4.3 7.2 5.0 1.5 1 1 0 1 1 1 0 TerY-C metal binding domain Prefoldin_2 PF01920.15 ESS63524.1 - 2.8e-16 59.1 5.9 2.8e-16 59.1 4.1 2.2 1 1 1 2 2 2 1 Prefoldin subunit GAS PF13851.1 ESS63524.1 - 0.035 13.2 0.6 0.035 13.2 0.4 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF948 PF06103.6 ESS63524.1 - 0.074 12.9 3.4 0.89 9.4 0.5 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF607 PF04678.8 ESS63524.1 - 0.23 11.3 2.7 0.36 10.7 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF607 Tropomyosin_1 PF12718.2 ESS63524.1 - 0.26 11.1 13.8 0.95 9.2 9.6 2.0 1 1 0 1 1 1 0 Tropomyosin like IncA PF04156.9 ESS63524.1 - 0.53 9.8 16.5 0.71 9.4 11.4 1.2 1 0 0 1 1 1 0 IncA protein UCH PF00443.24 ESS63524.1 - 1.1 8.3 3.9 1.3 8.0 2.7 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF1682 PF07946.9 ESS63524.1 - 1.1 7.9 9.6 1.8 7.3 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Mod_r PF07200.8 ESS63524.1 - 3.7 7.4 15.8 10 6.0 0.2 2.0 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2098 PF09871.4 ESS63524.1 - 8.7 6.3 8.1 0.99 9.3 2.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) Helicase_C_3 PF13625.1 ESS63527.1 - 0.11 12.2 0.1 0.96 9.2 0.0 2.1 1 1 1 2 2 2 0 Helicase conserved C-terminal domain RINT1_TIP1 PF04437.8 ESS63528.1 - 0.042 12.4 0.2 0.063 11.8 0.1 1.1 1 0 0 1 1 1 0 RINT-1 / TIP-1 family Frigida PF07899.6 ESS63528.1 - 0.089 11.5 0.4 0.19 10.4 0.3 1.5 1 1 0 1 1 1 0 Frigida-like protein CAF1 PF04857.15 ESS63529.1 - 1.2e-62 211.6 0.1 1.8e-62 211.0 0.0 1.3 1 1 0 1 1 1 1 CAF1 family ribonuclease IF-2 PF11987.3 ESS63530.1 - 0.037 13.8 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 Translation-initiation factor 2 DUF1131 PF06572.7 ESS63530.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1131) HALZ PF02183.13 ESS63530.1 - 0.16 11.7 1.7 6.1 6.6 0.1 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper ATP-synt_D PF01813.12 ESS63530.1 - 2.3 7.7 6.6 13 5.2 0.1 3.0 2 1 1 3 3 3 0 ATP synthase subunit D PPR_3 PF13812.1 ESS63531.1 - 0.086 13.1 0.5 0.34 11.2 0.0 2.3 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Motile_Sperm PF00635.21 ESS63533.1 - 1e-05 25.1 0.0 4.1 7.0 0.0 6.5 7 0 0 7 7 7 2 MSP (Major sperm protein) domain FixG_C PF11614.3 ESS63533.1 - 0.0019 18.2 0.0 2.1 8.4 0.0 4.8 5 0 0 5 5 5 1 IG-like fold at C-terminal of FixG, putative oxidoreductase MYCBPAP PF14646.1 ESS63533.1 - 0.024 13.3 0.0 25 3.4 0.0 3.5 2 1 1 3 3 3 0 MYCBP-associated protein family Metallophos PF00149.23 ESS63535.1 - 7.6e-12 45.0 0.1 2e-11 43.6 0.1 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESS63535.1 - 2.8e-06 27.2 0.0 5.8e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Gastrin PF00918.12 ESS63537.1 - 0.00098 19.9 1.6 0.0013 19.5 1.1 1.3 1 0 0 1 1 1 1 Gastrin/cholecystokinin family PRT_C PF08372.5 ESS63537.1 - 0.013 14.9 2.7 0.017 14.6 1.9 1.1 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Frag1 PF10277.4 ESS63537.1 - 0.014 14.8 0.5 0.016 14.6 0.3 1.0 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family FAM176 PF14851.1 ESS63537.1 - 0.038 13.6 6.0 0.041 13.5 4.2 1.1 1 0 0 1 1 1 0 FAM176 family VirB8 PF04335.8 ESS63537.1 - 0.048 13.2 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 VirB8 protein TRP PF06011.7 ESS63537.1 - 0.073 11.6 0.2 0.081 11.4 0.2 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF2701 PF10857.3 ESS63537.1 - 0.1 12.3 2.0 0.16 11.7 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) DUF3357 PF11837.3 ESS63537.1 - 0.11 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF2500 PF10694.4 ESS63537.1 - 0.11 12.4 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) BpuSI_N PF15516.1 ESS63537.1 - 0.15 11.7 0.3 0.18 11.4 0.2 1.2 1 0 0 1 1 1 0 BpuSI N-terminal domain DUF4233 PF14017.1 ESS63537.1 - 0.16 11.8 1.5 0.22 11.4 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4233) TMEM18 PF14770.1 ESS63537.1 - 1.2 8.6 4.2 2.2 7.8 2.8 1.6 1 1 1 2 2 2 0 Transmembrane protein 18 Med3 PF11593.3 ESS63538.1 - 0.98 8.5 7.2 0.029 13.6 0.9 1.6 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal RNase_PH PF01138.16 ESS63539.1 - 1e-09 38.8 0.0 2.2e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESS63539.1 - 7.4e-06 25.8 0.0 2.2e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 DUF3846 PF12957.2 ESS63539.1 - 0.023 14.3 0.0 0.86 9.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3846) tRNA-synt_2c PF01411.14 ESS63542.1 - 8.7e-191 634.9 0.0 1.1e-190 634.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 ESS63542.1 - 1.9e-11 43.6 0.0 3.9e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain HA2 PF04408.18 ESS63544.1 - 4.5e-16 58.7 0.1 1.2e-15 57.3 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS63544.1 - 4.7e-11 42.3 1.5 1.1e-10 41.2 0.1 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain R3H PF01424.17 ESS63544.1 - 7.8e-10 38.3 0.0 2.2e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 R3H domain DEAD PF00270.24 ESS63544.1 - 8.7e-10 38.3 0.1 1.7e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS63544.1 - 3.9e-05 23.8 0.1 0.00013 22.0 0.1 1.9 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESS63544.1 - 0.0067 15.3 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 ESS63544.1 - 0.025 14.3 0.0 2.3 8.0 0.0 3.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESS63544.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Metallophos PF00149.23 ESS63545.1 - 1.8e-06 27.4 0.3 3.7e-06 26.4 0.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF4504 PF14953.1 ESS63545.1 - 0.011 15.0 0.0 3.4 6.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4504) Metallophos_2 PF12850.2 ESS63545.1 - 0.094 12.5 0.0 0.34 10.7 0.0 1.9 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain ABC_tran PF00005.22 ESS63546.1 - 9.2e-27 94.0 0.0 1.8e-26 93.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS63546.1 - 7.3e-08 32.7 0.3 0.00018 21.5 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESS63546.1 - 0.0015 18.0 0.2 0.0032 16.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_10 PF12846.2 ESS63546.1 - 0.0021 17.5 0.3 0.46 9.8 0.1 2.2 2 0 0 2 2 2 2 AAA-like domain DUF258 PF03193.11 ESS63546.1 - 0.006 15.7 0.1 0.011 14.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SbcCD_C PF13558.1 ESS63546.1 - 0.0068 16.2 0.3 0.075 12.9 0.2 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 ESS63546.1 - 0.0093 15.3 2.9 0.092 12.1 0.1 2.7 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 ESS63546.1 - 0.017 15.1 1.3 0.042 13.8 0.9 1.9 1 1 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.14 ESS63546.1 - 0.02 14.1 0.8 0.13 11.4 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ESS63546.1 - 0.073 13.9 0.3 0.23 12.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 ESS63546.1 - 0.11 12.6 1.6 0.91 9.6 1.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.1 ESS63546.1 - 0.21 10.6 0.0 1.1 8.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain ABC_ATPase PF09818.4 ESS63546.1 - 0.93 7.9 5.6 9.4 4.6 0.2 2.9 2 1 0 2 2 2 0 Predicted ATPase of the ABC class Hexapep PF00132.19 ESS63547.1 - 6.9e-15 53.7 0.5 3.9e-05 22.9 0.0 3.3 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) D5_N PF08706.6 ESS63547.1 - 0.052 13.6 0.2 0.078 13.0 0.2 1.2 1 0 0 1 1 1 0 D5 N terminal like Hexapep_2 PF14602.1 ESS63547.1 - 0.059 12.9 1.1 2.2 7.8 0.0 2.9 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase COPIIcoated_ERV PF07970.7 ESS63548.1 - 3.9e-51 173.7 0.1 5.6e-51 173.2 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 ESS63548.1 - 1.3e-25 89.2 0.1 2.3e-25 88.3 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF1282 PF06930.7 ESS63548.1 - 0.074 12.7 0.3 7.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1282) Methyltransf_26 PF13659.1 ESS63550.1 - 0.0019 18.2 0.0 0.0047 16.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain AAA_22 PF13401.1 ESS63551.1 - 1.8e-08 34.6 0.0 4.5e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESS63551.1 - 9.3e-07 29.1 0.0 2.9e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS63551.1 - 0.00022 21.2 0.0 0.00089 19.2 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain NACHT PF05729.7 ESS63551.1 - 0.0068 16.0 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Arch_ATPase PF01637.13 ESS63551.1 - 0.0089 15.7 0.0 0.035 13.8 0.0 1.9 1 1 0 1 1 1 1 Archaeal ATPase AAA_19 PF13245.1 ESS63551.1 - 0.022 14.4 0.6 0.057 13.1 0.0 2.0 2 0 0 2 2 2 0 Part of AAA domain DUF2075 PF09848.4 ESS63551.1 - 0.098 11.6 0.0 0.18 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T2SE PF00437.15 ESS63551.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PPR PF01535.15 ESS63552.1 - 8.5e-09 34.8 1.6 0.0049 16.7 0.1 5.6 6 0 0 6 6 6 2 PPR repeat PPR_2 PF13041.1 ESS63552.1 - 3.2e-07 30.2 0.3 0.017 15.1 0.0 4.9 3 1 2 5 5 5 3 PPR repeat family PPR_3 PF13812.1 ESS63552.1 - 0.00072 19.6 0.1 64 4.1 0.0 6.3 6 0 0 6 6 6 0 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESS63552.1 - 0.018 14.5 0.0 0.89 9.0 0.0 2.8 3 0 0 3 3 3 0 PPR repeat Beach PF02138.13 ESS63553.1 - 2.8e-90 302.4 0.0 4.6e-90 301.7 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 ESS63553.1 - 1e-09 38.1 0.0 2.1e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 ESS63553.1 - 4.9e-05 23.0 0.4 0.029 14.2 0.0 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat zf-DHHC PF01529.15 ESS63554.1 - 8.9e-33 113.1 12.5 8.9e-33 113.1 8.7 1.5 1 1 0 1 1 1 1 DHHC palmitoyltransferase Baculo_11_kDa PF06143.6 ESS63554.1 - 0.018 14.3 1.1 0.018 14.3 0.7 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family NYD-SP28_assoc PF14775.1 ESS63555.1 - 1.6e-07 30.9 6.5 1.6e-07 30.9 4.5 2.7 2 0 0 2 2 2 1 Sperm tail C-terminal domain NYD-SP28 PF14772.1 ESS63555.1 - 1.7e-07 31.2 11.1 1.7e-07 31.2 7.7 5.0 3 3 2 5 5 5 1 Sperm tail NFRKB_winged PF14465.1 ESS63555.1 - 0.039 13.7 3.3 4.5 7.1 0.1 3.0 1 1 1 2 2 2 0 NFRKB Winged Helix-like Baculo_PEP_C PF04513.7 ESS63555.1 - 0.48 10.2 8.9 4.8 7.0 0.3 3.4 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mesothelin PF06060.7 ESS63557.1 - 0.15 10.0 0.0 0.21 9.5 0.0 1.1 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Exo_endo_phos PF03372.18 ESS63560.1 - 2e-11 44.2 0.0 2.5e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Fumble PF03630.9 ESS63561.1 - 2.7e-74 250.0 0.0 4.1e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 Fumble AMP-binding PF00501.23 ESS63561.1 - 2.1e-16 59.3 0.7 3.9e-10 38.7 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme MFS_1 PF07690.11 ESS63562.1 - 1.8e-28 99.3 41.3 6.8e-27 94.1 29.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Adeno_E3B PF03376.9 ESS63562.1 - 0.042 13.7 0.0 0.042 13.7 0.0 2.9 3 0 0 3 3 3 0 Adenovirus E3B protein RRM_6 PF14259.1 ESS63563.1 - 0.0032 17.4 0.0 1.9 8.5 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CENP_C_N PF15622.1 ESS63563.1 - 0.0057 15.9 0.7 0.0087 15.3 0.5 1.2 1 0 0 1 1 1 1 Kinetochore assembly subunit CENP-C N-terminal DUF1840 PF08895.6 ESS63563.1 - 0.093 12.7 2.5 0.45 10.5 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DSPc PF00782.15 ESS63564.1 - 5.6e-31 106.8 0.0 9.4e-31 106.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.1 ESS63564.1 - 8.6e-11 41.4 16.6 2.2e-07 30.5 1.4 3.4 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.2 ESS63564.1 - 1.3e-08 34.3 6.2 9.1e-05 21.9 0.4 3.3 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS63564.1 - 1.6e-06 27.2 4.7 0.24 11.5 0.0 4.9 5 0 0 5 5 5 2 Leucine Rich Repeat Y_phosphatase PF00102.22 ESS63564.1 - 0.003 16.9 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_7 PF13504.1 ESS63564.1 - 0.01 15.8 8.1 0.94 9.9 0.1 4.1 4 0 0 4 4 4 0 Leucine rich repeat CDKN3 PF05706.7 ESS63564.1 - 0.075 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) LRR_6 PF13516.1 ESS63564.1 - 0.11 12.5 1.7 28 5.2 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Phospholamban PF04272.9 ESS63565.1 - 0.098 12.1 1.3 0.31 10.5 0.9 1.8 1 0 0 1 1 1 0 Phospholamban DUF4266 PF14086.1 ESS63565.1 - 3.3 8.2 13.0 0.19 12.2 0.9 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) Aminotran_5 PF00266.14 ESS63566.1 - 3.5e-10 39.1 0.0 7.4e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V zf-DHHC PF01529.15 ESS63567.1 - 2.4e-28 98.6 0.1 2.4e-28 98.6 0.1 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase Consortin_C PF15281.1 ESS63567.1 - 0.034 13.6 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 Consortin C-terminus DUF912 PF06024.7 ESS63567.1 - 0.15 12.0 0.2 0.49 10.4 0.1 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4577 PF15145.1 ESS63567.1 - 0.33 10.8 1.3 9.6 6.1 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Hydrolase_3 PF08282.7 ESS63568.1 - 1.7e-41 142.4 0.0 6.3e-41 140.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 ESS63568.1 - 4.3e-13 49.1 0.1 5.5e-07 29.1 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.21 ESS63568.1 - 7.5e-05 23.2 0.4 0.0012 19.3 0.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS63568.1 - 0.025 14.7 0.1 0.29 11.2 0.1 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.9 ESS63568.1 - 0.13 11.5 0.2 1.3 8.3 0.0 2.2 1 1 1 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) PYNP_C PF07831.8 ESS63569.1 - 0.057 12.8 0.0 0.094 12.1 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain Mpv17_PMP22 PF04117.7 ESS63570.1 - 0.0071 15.9 0.0 0.016 14.8 0.0 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family Histone PF00125.19 ESS63571.1 - 4.9e-15 55.4 0.3 6.6e-15 54.9 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESS63571.1 - 0.021 14.8 0.1 0.036 14.1 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HTH_9 PF08221.6 ESS63571.1 - 0.08 12.8 0.1 0.48 10.3 0.0 2.0 1 1 1 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF588 PF04535.7 ESS63572.1 - 0.048 13.2 2.1 0.075 12.6 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF588) Proteasome PF00227.21 ESS63573.1 - 1.7e-37 128.5 0.0 1.9e-37 128.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DGF-1_4 PF11024.3 ESS63574.1 - 7.9e-43 144.7 14.7 7.9e-43 144.7 10.2 1.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 DGF-1_5 PF11038.3 ESS63575.1 - 1.8e-151 503.0 19.6 2.1e-151 502.8 13.6 1.0 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 HEV_ORF1 PF02444.11 ESS63575.1 - 0.093 12.9 7.2 0.19 11.9 0.6 2.5 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) Galactosyl_T PF01762.16 ESS63577.1 - 1.4e-05 24.7 0.0 0.00063 19.3 0.0 2.3 1 1 1 2 2 2 2 Galactosyltransferase RCC1 PF00415.13 ESS63578.1 - 6.9e-23 80.6 8.8 1.7e-09 37.7 0.0 7.1 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS63578.1 - 2e-18 65.5 18.7 1.5e-07 30.8 0.3 6.3 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat EMP24_GP25L PF01105.19 ESS63579.1 - 6.4e-32 110.7 0.0 8.7e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD PLAC8 PF04749.12 ESS63579.1 - 0.069 13.7 1.5 0.17 12.4 0.1 2.1 2 0 0 2 2 2 0 PLAC8 family Yip1 PF04893.12 ESS63579.1 - 0.084 12.3 2.2 0.32 10.4 0.2 2.1 2 0 0 2 2 2 0 Yip1 domain COPIIcoated_ERV PF07970.7 ESS63580.1 - 5.4e-68 228.9 0.0 7.9e-68 228.3 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 ESS63580.1 - 2.9e-27 94.4 0.0 5.9e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) QueC PF06508.8 ESS63580.1 - 0.0069 15.6 0.4 0.012 14.9 0.2 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC DUF3437 PF11919.3 ESS63580.1 - 0.044 13.4 0.2 0.1 12.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) Ly49 PF08391.5 ESS63580.1 - 0.06 13.4 0.1 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF165 PF02592.10 ESS63580.1 - 0.09 12.9 0.2 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized ACR, YhhQ family COG1738 DUF972 PF06156.8 ESS63581.1 - 1.4 9.3 6.1 5.4 7.4 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) MgrB PF13998.1 ESS63582.1 - 0.093 12.5 0.6 0.59 9.9 0.0 2.4 2 0 0 2 2 2 0 MgrB protein DUF1771 PF08590.5 ESS63583.1 - 7.8e-21 73.8 9.6 7.8e-21 73.8 6.6 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) KH_1 PF00013.24 ESS63583.1 - 9.2e-12 44.4 1.8 1.7e-11 43.5 0.9 1.7 2 0 0 2 2 2 1 KH domain Smr PF01713.16 ESS63583.1 - 4.9e-10 39.4 0.0 1.7e-09 37.6 0.0 2.0 1 0 0 1 1 1 1 Smr domain KH_3 PF13014.1 ESS63583.1 - 1.7e-08 33.9 0.2 4e-08 32.7 0.1 1.7 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 ESS63583.1 - 0.00011 21.6 0.3 0.00029 20.3 0.2 1.6 1 0 0 1 1 1 1 KH domain Cadherin_C PF01049.12 ESS63583.1 - 0.024 14.6 0.8 0.12 12.4 0.1 2.1 2 0 0 2 2 2 0 Cadherin cytoplasmic region NPBW PF15180.1 ESS63584.1 - 0.04 13.5 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Neuropeptides B and W Maf1 PF09174.5 ESS63585.1 - 7.9e-36 123.5 0.0 9.7e-36 123.2 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator Med3 PF11593.3 ESS63586.1 - 1.2 8.2 18.8 1.6 7.8 13.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4084 PF13321.1 ESS63587.1 - 0.012 14.8 0.4 0.016 14.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4084) Ribosomal_L12 PF00542.14 ESS63588.1 - 3e-17 62.3 1.2 5.2e-17 61.5 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Pkinase PF00069.20 ESS63589.1 - 4.3e-58 196.5 0.0 8e-58 195.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63589.1 - 7.3e-32 110.4 0.0 1.4e-31 109.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63589.1 - 0.0011 17.9 0.0 0.0033 16.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like CBFD_NFYB_HMF PF00808.18 ESS63589.1 - 0.002 18.1 0.2 0.053 13.5 0.0 3.0 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pox_ser-thr_kin PF05445.6 ESS63589.1 - 0.016 14.0 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase THF_DHG_CYH PF00763.18 ESS63589.1 - 0.17 11.8 0.7 0.39 10.7 0.5 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain MscS_porin PF12795.2 ESS63589.1 - 0.65 9.2 19.7 2.2 7.5 3.3 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Spc7 PF08317.6 ESS63589.1 - 1.8 7.1 14.5 0.5 8.9 0.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DivIC PF04977.10 ESS63589.1 - 2.5 7.6 9.7 1.3 8.6 0.1 3.2 3 0 0 3 3 3 0 Septum formation initiator DUF4140 PF13600.1 ESS63589.1 - 2.6 8.5 14.3 0.5 10.8 0.7 3.6 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) TBPIP PF07106.8 ESS63589.1 - 3.5 7.1 11.1 8.9 5.8 0.4 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SlyX PF04102.7 ESS63589.1 - 7.2 7.0 12.3 3.3 8.1 0.4 3.5 2 2 1 3 3 3 0 SlyX Clathrin PF00637.15 ESS63591.1 - 1.3e-15 57.2 3.9 2.4e-14 53.1 1.0 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.3 ESS63591.1 - 5.6e-11 42.1 0.0 1.4e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal TPR_11 PF13414.1 ESS63591.1 - 0.0056 16.2 0.5 0.032 13.8 0.0 2.5 2 0 0 2 2 2 1 TPR repeat Vps8 PF12816.2 ESS63591.1 - 0.018 14.2 1.1 0.025 13.8 0.2 1.6 2 0 0 2 2 2 0 Golgi CORVET complex core vacuolar protein 8 SBP_bac_11 PF13531.1 ESS63591.1 - 0.067 12.8 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein TPR_21 PF09976.4 ESS63591.1 - 0.12 12.3 3.1 0.61 10.0 0.6 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-C3HC4_2 PF13923.1 ESS63591.1 - 0.16 12.0 9.4 0.42 10.6 6.5 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 ESS63591.1 - 0.26 11.1 2.7 0.64 9.8 1.9 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 ESS63591.1 - 0.85 9.4 11.2 2 8.1 7.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 ESS63591.1 - 0.86 9.4 11.3 2.5 7.9 7.8 1.8 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.2 ESS63591.1 - 0.94 9.6 8.7 2.2 8.4 6.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger Prok-RING_1 PF14446.1 ESS63591.1 - 1.5 8.6 7.5 4.3 7.1 5.2 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Ca_chan_IQ PF08763.6 ESS63592.1 - 0.0049 16.0 0.1 0.0086 15.2 0.1 1.4 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PQQ_3 PF13570.1 ESS63592.1 - 0.01 16.0 0.0 0.6 10.4 0.0 3.1 2 0 0 2 2 2 0 PQQ-like domain Nup54 PF13874.1 ESS63593.1 - 9.5e-33 112.8 1.2 9.5e-33 112.8 0.9 1.4 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 DUF1875 PF08961.5 ESS63593.1 - 0.0055 16.0 0.5 0.02 14.1 0.4 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF1875) Mad3_BUB1_I PF08311.7 ESS63593.1 - 0.0069 16.1 0.1 0.35 10.6 0.1 2.3 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 DUF1819 PF08849.6 ESS63593.1 - 0.016 14.6 0.8 0.036 13.4 0.0 1.9 2 1 0 2 2 2 0 Putative inner membrane protein (DUF1819) DUF4588 PF15251.1 ESS63594.1 - 0.0039 17.1 2.0 0.03 14.3 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4588) Inositol_P PF00459.20 ESS63595.1 - 4e-23 82.0 0.0 6.8e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family SQS_PSY PF00494.14 ESS63596.1 - 3.1e-42 144.7 0.2 3.1e-42 144.7 0.2 1.5 2 0 0 2 2 2 1 Squalene/phytoene synthase Pkinase PF00069.20 ESS63597.1 - 4.5e-61 206.2 0.0 5.8e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63597.1 - 2.5e-41 141.4 0.0 3.5e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63597.1 - 2.3e-08 33.3 0.0 4.2e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PH PF00169.24 ESS63597.1 - 0.0073 16.4 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Pox_ser-thr_kin PF05445.6 ESS63597.1 - 0.047 12.4 0.1 0.072 11.8 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Carboxyl_trans PF01039.17 ESS63598.1 - 2.6e-126 421.9 0.0 7.2e-126 420.4 0.0 1.6 2 0 0 2 2 2 1 Carboxyl transferase domain ACC_central PF08326.7 ESS63598.1 - 3.9e-98 329.4 0.3 7.5e-93 311.9 0.1 2.2 2 0 0 2 2 2 2 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.12 ESS63598.1 - 2e-47 161.1 0.0 3.6e-47 160.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESS63598.1 - 2.9e-24 85.2 0.0 6.9e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESS63598.1 - 7.4e-21 74.1 0.0 2e-20 72.7 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 ESS63598.1 - 1.3e-13 51.0 0.1 5.2e-13 49.1 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESS63598.1 - 3.5e-12 45.7 0.0 8.1e-08 31.3 0.0 2.7 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl PF00364.17 ESS63598.1 - 5.4e-10 38.7 0.0 1.4e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.8 ESS63598.1 - 1.6e-06 27.6 0.0 4.2e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 ESS63598.1 - 0.00024 20.4 0.0 0.00069 19.0 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESS63598.1 - 0.29 10.8 0.0 0.88 9.2 0.0 1.8 1 0 0 1 1 1 0 Biotin-lipoyl like SMK-1 PF04802.10 ESS63599.1 - 2.7e-07 30.3 0.0 4.7e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Ribosomal_60s PF00428.14 ESS63599.1 - 0.0011 19.3 7.5 0.003 17.9 4.9 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein DUF1117 PF06547.7 ESS63600.1 - 6.1 6.9 11.3 12 6.0 1.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) A_deaminase PF00962.17 ESS63601.1 - 0.045 12.6 3.5 0.06 12.2 2.4 1.1 1 0 0 1 1 1 0 Adenosine/AMP deaminase CRISPR_Cse1 PF09481.5 ESS63601.1 - 0.17 10.5 7.1 0.086 11.5 3.4 1.5 1 1 1 2 2 2 0 CRISPR-associated protein Cse1 (CRISPR_cse1) M PF02370.11 ESS63601.1 - 1.3 9.6 4.4 31 5.3 0.9 3.5 2 0 0 2 2 2 0 M protein repeat IFT57 PF10498.4 ESS63601.1 - 1.5 7.4 9.8 2.1 7.0 6.8 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Exonuc_VII_L PF02601.10 ESS63601.1 - 1.8 7.6 7.8 2.3 7.3 5.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Kinesin PF00225.18 ESS63604.1 - 7.8e-05 21.5 0.0 0.00032 19.5 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain DUF1324 PF07038.6 ESS63604.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1324) Exonuc_V_gamma PF04257.9 ESS63604.1 - 0.048 11.6 1.9 0.13 10.1 0.1 2.0 2 0 0 2 2 2 0 Exodeoxyribonuclease V, gamma subunit Glyco_hydro_46 PF01374.13 ESS63604.1 - 0.27 10.7 1.5 0.61 9.5 1.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 RP-C_C PF11800.3 ESS63604.1 - 0.43 10.2 4.2 2.3 7.8 0.2 2.5 2 0 0 2 2 2 0 Replication protein C C-terminal region RE_HindVP PF09519.5 ESS63605.1 - 0.014 14.2 0.1 0.028 13.3 0.1 1.4 1 0 0 1 1 1 0 HindVP restriction endonuclease IGR PF09597.5 ESS63605.1 - 0.096 12.6 0.1 11 6.0 0.0 2.5 2 0 0 2 2 2 0 IGR protein motif DUF2419 PF10343.4 ESS63607.1 - 0.14 11.4 0.1 0.22 10.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2419) ADP_ribosyl_GH PF03747.9 ESS63608.1 - 0.056 13.2 0.3 0.098 12.4 0.2 1.3 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase RIC3 PF15361.1 ESS63608.1 - 0.59 10.3 3.3 0.41 10.8 1.1 1.6 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 TBCA PF02970.11 ESS63608.1 - 0.77 9.8 5.9 1.6 8.8 0.3 2.7 2 0 0 2 2 2 0 Tubulin binding cofactor A Kinesin PF00225.18 ESS63609.1 - 0.00075 18.2 0.0 0.081 11.6 0.0 2.1 2 0 0 2 2 2 2 Kinesin motor domain Sec8_exocyst PF04048.9 ESS63611.1 - 0.077 12.6 0.1 0.22 11.1 0.1 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Atrophin-1 PF03154.10 ESS63616.1 - 0.49 8.4 10.6 0.69 7.9 7.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family Peptidase_S49_N PF08496.5 ESS63616.1 - 0.53 10.0 4.8 0.79 9.5 3.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PPP4R2 PF09184.6 ESS63616.1 - 0.66 9.4 11.5 0.97 8.9 8.0 1.2 1 0 0 1 1 1 0 PPP4R2 RR_TM4-6 PF06459.7 ESS63616.1 - 0.78 9.5 8.2 1.1 9.0 5.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PBP1_TM PF14812.1 ESS63616.1 - 1.5 9.1 10.7 0.21 11.9 4.2 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IncA PF04156.9 ESS63618.1 - 0.00042 19.9 13.9 0.00042 19.9 9.6 5.7 1 1 5 6 6 6 1 IncA protein TPD52 PF04201.10 ESS63618.1 - 0.0013 18.4 7.1 0.0013 18.4 5.0 5.5 3 2 3 7 7 7 1 Tumour protein D52 family GAS PF13851.1 ESS63618.1 - 0.25 10.5 78.9 0.066 12.3 8.0 5.2 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding HECT PF00632.20 ESS63619.1 - 4.8e-10 39.0 0.0 0.00019 20.6 0.0 3.1 3 0 0 3 3 3 3 HECT-domain (ubiquitin-transferase) PspB PF06667.7 ESS63620.1 - 0.061 13.2 0.1 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein B CECR6_TMEM121 PF14997.1 ESS63621.1 - 8e-07 28.8 4.5 1.1e-05 25.1 3.1 2.2 1 1 0 1 1 1 1 CECR6/TMEM121 family PPO1_DWL PF12142.3 ESS63622.1 - 0.022 14.2 0.2 0.82 9.2 0.0 2.4 2 0 0 2 2 2 0 Polyphenol oxidase middle domain TSA PF03249.8 ESS63622.1 - 0.83 8.1 4.4 1.3 7.4 3.1 1.3 1 0 0 1 1 1 0 Type specific antigen FAD_binding_3 PF01494.14 ESS63623.1 - 5.6e-11 42.0 0.2 9.1e-08 31.5 0.2 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 ESS63623.1 - 5.1e-07 29.6 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESS63623.1 - 3.1e-06 26.3 0.2 0.00023 20.1 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESS63623.1 - 3.5e-05 24.1 0.0 0.00013 22.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESS63623.1 - 8.2e-05 21.6 0.0 0.00023 20.1 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 ESS63623.1 - 0.0053 16.6 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESS63623.1 - 0.0096 14.8 0.0 0.032 13.1 0.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.12 ESS63623.1 - 0.025 13.6 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 ESS63623.1 - 0.025 14.6 0.1 0.33 10.9 0.0 2.4 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESS63623.1 - 0.029 14.1 0.1 3.4 7.4 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding DMPK_coil PF08826.5 ESS63625.1 - 0.021 14.6 0.3 0.021 14.6 0.2 3.2 3 0 0 3 3 3 0 DMPK coiled coil domain like GrpE PF01025.14 ESS63625.1 - 1 8.9 9.2 0.1 12.1 1.5 2.5 2 1 0 2 2 2 0 GrpE Pam16 PF03656.8 ESS63626.1 - 0.019 14.7 0.6 0.035 13.9 0.4 1.3 1 0 0 1 1 1 0 Pam16 PqiA PF04403.8 ESS63627.1 - 4.6e-14 52.2 14.7 2.8e-13 49.7 6.1 2.6 2 1 0 2 2 2 2 Paraquat-inducible protein A Rootletin PF15035.1 ESS63628.1 - 0.0073 16.3 2.5 0.013 15.4 1.8 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion HAP1_N PF04849.8 ESS63628.1 - 0.027 13.4 0.6 0.044 12.7 0.4 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region WW PF00397.21 ESS63628.1 - 0.34 10.8 0.0 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 WW domain Dala_Dala_lig_C PF07478.8 ESS63629.1 - 1e-12 47.8 0.0 1.7e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.1 ESS63629.1 - 3.9e-12 46.2 0.0 9.8e-12 44.9 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain SET PF00856.23 ESS63629.1 - 5.4e-12 46.3 0.3 1.9e-10 41.3 0.2 2.3 1 1 0 1 1 1 1 SET domain ATP-grasp_3 PF02655.9 ESS63629.1 - 0.00013 21.8 0.0 0.00026 20.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 ESS63629.1 - 0.00016 21.0 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 ESS63629.1 - 0.042 13.3 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TPR_7 PF13176.1 ESS63630.1 - 0.004 16.8 0.1 8.4 6.4 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat Ribosomal_L28e PF01778.12 ESS63631.1 - 0.067 13.6 4.6 0.077 13.3 3.2 1.1 1 0 0 1 1 1 0 Ribosomal L28e protein family Cut8_N PF14482.1 ESS63631.1 - 0.07 13.1 5.7 0.096 12.7 3.6 1.6 1 1 0 1 1 1 0 Cut8 proteasome-binding domain DUF3080 PF11279.3 ESS63631.1 - 0.084 11.9 0.9 0.089 11.9 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) Pox_Ag35 PF03286.9 ESS63631.1 - 0.15 11.5 9.2 0.16 11.4 6.4 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein LsmAD PF06741.8 ESS63631.1 - 0.19 11.8 5.5 0.27 11.3 3.8 1.4 1 1 0 1 1 1 0 LsmAD domain U79_P34 PF03064.11 ESS63631.1 - 0.33 10.4 6.6 0.34 10.3 4.5 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Ribosomal_60s PF00428.14 ESS63631.1 - 0.73 10.2 6.0 0.96 9.8 4.2 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein BLVR PF06375.6 ESS63631.1 - 2.9 7.7 10.1 3.5 7.4 7.0 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) ORC6 PF05460.8 ESS63631.1 - 3.5 6.6 9.5 3.9 6.4 6.6 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PBP1_TM PF14812.1 ESS63631.1 - 4 7.8 10.8 6.5 7.1 7.5 1.6 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF755 PF05501.6 ESS63631.1 - 4.7 7.2 14.2 5.6 7.0 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Presenilin PF01080.12 ESS63631.1 - 6.7 5.4 6.8 6.8 5.4 4.7 1.0 1 0 0 1 1 1 0 Presenilin Phyto_Pns9_10 PF05878.6 ESS63631.1 - 7 5.5 6.3 7.9 5.3 4.4 1.0 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Dicty_REP PF05086.7 ESS63631.1 - 7.8 4.1 8.0 7.9 4.0 5.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pkinase PF00069.20 ESS63632.1 - 8.5e-47 159.4 0.0 1.2e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63632.1 - 5.7e-26 91.1 0.0 1.1e-25 90.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESS63632.1 - 7.3e-12 45.0 12.1 2.4e-11 43.3 8.3 2.0 1 1 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESS63632.1 - 0.00085 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS63632.1 - 0.001 18.4 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 ESS63632.1 - 0.08 12.5 0.2 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase MORN PF02493.15 ESS63633.1 - 3.8e-34 114.3 56.4 3.4e-05 23.3 0.0 10.7 10 1 0 10 10 10 9 MORN repeat PH PF00169.24 ESS63633.1 - 1.6e-08 34.7 0.1 2.8e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESS63633.1 - 0.0019 18.3 0.2 0.011 15.9 0.1 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 ESS63633.1 - 0.15 12.1 0.0 3 7.9 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain ATP-synt_ab_N PF02874.18 ESS63634.1 - 0.061 13.5 1.1 0.18 12.0 0.1 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain DUF3772 PF12607.3 ESS63635.1 - 0.11 12.1 0.0 0.35 10.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Pkinase PF00069.20 ESS63637.1 - 3.6e-53 180.3 0.0 4.3e-53 180.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63637.1 - 7e-36 123.6 0.0 8.5e-36 123.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63637.1 - 3.5e-11 42.6 0.0 6.1e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESS63637.1 - 0.0026 17.1 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESS63637.1 - 0.0059 15.6 0.1 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS63637.1 - 0.0089 15.7 2.5 0.025 14.2 1.8 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESS63637.1 - 0.031 13.6 0.1 0.056 12.7 0.0 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL JAB PF01398.16 ESS63638.1 - 1.6e-20 72.9 2.2 2.1e-19 69.3 1.5 2.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESS63638.1 - 5e-10 38.9 0.9 4.9e-09 35.7 0.6 2.2 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain TPR_11 PF13414.1 ESS63640.1 - 1.2e-27 95.2 12.6 3.6e-08 32.9 0.6 6.1 5 1 1 6 6 6 4 TPR repeat TPR_2 PF07719.12 ESS63640.1 - 1.7e-23 80.5 13.2 0.00038 20.1 0.0 8.7 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_1 PF00515.23 ESS63640.1 - 1.2e-18 65.8 12.0 4.4e-05 22.9 0.1 7.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63640.1 - 4.5e-17 61.7 14.9 1.1e-05 25.2 0.0 6.4 5 1 2 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESS63640.1 - 1.1e-14 54.5 9.9 0.0019 18.8 0.5 6.8 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS63640.1 - 5.1e-14 52.3 2.4 0.001 19.3 0.0 6.0 5 1 1 6 6 6 3 Tetratricopeptide repeat Apc3 PF12895.2 ESS63640.1 - 1.8e-11 44.0 10.2 0.0013 18.8 0.1 4.7 3 3 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESS63640.1 - 2.5e-11 42.4 7.0 0.28 11.0 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63640.1 - 7.2e-09 35.5 6.3 1.1 10.0 0.0 7.8 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63640.1 - 3.1e-08 32.8 1.9 5.8 6.9 0.0 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63640.1 - 3.8e-08 32.9 2.3 0.71 10.2 0.0 7.4 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63640.1 - 0.0026 18.1 12.2 8.3 7.1 0.0 7.5 9 1 1 10 10 8 0 Tetratricopeptide repeat TPR_15 PF13429.1 ESS63640.1 - 0.003 16.6 0.4 0.43 9.6 0.0 3.9 4 2 1 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS63640.1 - 0.0053 16.6 6.9 8.8 6.2 0.0 5.6 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 ESS63640.1 - 0.0069 16.2 11.5 1.6 8.6 0.0 5.4 5 1 1 6 6 5 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESS63640.1 - 0.018 15.2 1.0 3.5 7.8 0.0 2.6 3 0 0 3 3 2 0 Alkyl sulfatase dimerisation DUF3856 PF12968.2 ESS63640.1 - 0.043 13.6 2.8 0.066 13.0 0.4 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_10 PF13374.1 ESS63640.1 - 0.15 12.0 16.8 3.8 7.5 0.1 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat PDZ_2 PF13180.1 ESS63645.1 - 8.6e-11 41.5 0.0 2.7e-10 40.0 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 ESS63645.1 - 4.1e-07 30.0 0.0 8.2e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PI-PLC-X PF00388.14 ESS63645.1 - 6e-05 22.4 0.0 0.0007 19.0 0.0 2.4 2 1 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.6 ESS63645.1 - 0.0019 18.1 0.1 0.0044 16.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like Hexapep PF00132.19 ESS63647.1 - 8.7e-06 25.0 0.5 0.0028 17.0 0.0 4.1 4 1 1 5 5 5 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESS63647.1 - 6.5e-05 22.3 0.7 0.0015 18.0 0.0 2.9 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase tRNA-synt_His PF13393.1 ESS63648.1 - 1.4e-42 145.8 0.0 2.2e-42 145.2 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 ESS63648.1 - 4.8e-15 55.5 0.0 7.1e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESS63648.1 - 5.2e-06 26.3 0.3 1.3e-05 25.0 0.1 1.8 2 0 0 2 2 2 1 Anticodon binding domain Cyt-b5 PF00173.23 ESS63649.1 - 9.7e-30 102.1 0.0 4.1e-13 48.9 0.0 3.2 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.19 ESS63649.1 - 2e-10 40.6 0.0 4.2e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESS63649.1 - 5.6e-08 33.3 0.1 1.3e-06 28.8 0.0 2.5 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESS63649.1 - 6.1e-06 26.2 0.5 0.0015 18.4 0.1 2.9 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Smr PF01713.16 ESS63649.1 - 0.01 16.0 0.3 6 7.1 0.0 3.4 3 0 0 3 3 3 1 Smr domain MazG PF03819.12 ESS63649.1 - 0.13 12.1 1.1 0.34 10.8 0.1 2.1 2 0 0 2 2 2 0 MazG nucleotide pyrophosphohydrolase domain Pkinase PF00069.20 ESS63650.1 - 6.6e-69 231.9 0.0 8.7e-69 231.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63650.1 - 1.3e-42 145.6 0.0 1.9e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63650.1 - 3.4e-09 36.0 0.0 1.6e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.17 ESS63650.1 - 0.0029 16.9 0.0 0.0067 15.7 0.0 1.5 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESS63650.1 - 0.0042 16.8 0.6 0.49 10.0 0.2 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family BBS2_C PF14782.1 ESS63651.1 - 1.2e-138 462.2 0.0 1.7e-138 461.7 0.0 1.2 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_N PF14781.1 ESS63651.1 - 1.1e-35 122.2 0.1 2.4e-35 121.1 0.1 1.6 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, N-terminal BBS2_Mid PF14783.1 ESS63651.1 - 3.1e-33 113.8 0.0 1.7e-32 111.4 0.0 2.2 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.18 ESS63651.1 - 0.0049 16.5 0.0 0.017 14.8 0.0 1.9 1 0 0 1 1 1 1 FG-GAP repeat VCBS PF13517.1 ESS63651.1 - 0.041 14.2 0.1 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FlgN PF05130.7 ESS63651.1 - 0.22 11.7 8.1 0.38 10.9 0.6 2.3 2 0 0 2 2 2 0 FlgN protein AMP-binding PF00501.23 ESS63652.1 - 8.1e-18 64.0 0.0 4e-10 38.6 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme UPF0137 PF03677.8 ESS63653.1 - 0.022 14.2 0.8 2.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0137) DUF1192 PF06698.6 ESS63653.1 - 0.045 13.5 4.6 4.6 7.1 1.4 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) Cep57_CLD_2 PF14197.1 ESS63653.1 - 0.047 13.6 10.7 0.078 12.9 5.7 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Polysacc_deac_1 PF01522.16 ESS63653.1 - 0.76 9.4 3.5 4 7.1 0.9 2.9 2 1 0 2 2 2 0 Polysaccharide deacetylase PSP PF04046.11 ESS63654.1 - 8.3e-19 66.7 4.9 1.7e-18 65.7 3.4 1.6 1 0 0 1 1 1 1 PSP DUF382 PF04037.8 ESS63654.1 - 1.6e-13 50.6 2.4 9.4e-12 44.8 0.0 2.6 3 0 0 3 3 3 2 Domain of unknown function (DUF382) QCR10 PF09796.4 ESS63654.1 - 0.097 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Med3 PF11593.3 ESS63654.1 - 6.9 5.8 13.5 11 5.0 6.3 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DUF2458 PF10454.4 ESS63655.1 - 0.012 15.5 1.9 0.012 15.5 1.3 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) DUF148 PF02520.12 ESS63655.1 - 0.06 13.1 3.7 0.11 12.3 0.7 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF148 MinE PF03776.9 ESS63655.1 - 0.13 11.8 3.1 0.9 9.1 0.2 3.2 3 0 0 3 3 3 0 Septum formation topological specificity factor MinE LMBR1 PF04791.11 ESS63656.1 - 4.5e-27 94.7 19.7 2.4e-26 92.3 13.7 1.9 1 1 0 1 1 1 1 LMBR1-like membrane protein Alg14 PF08660.6 ESS63657.1 - 3.1e-54 183.5 0.0 5.6e-54 182.6 0.0 1.4 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_tran_28_C PF04101.11 ESS63657.1 - 3.9e-26 91.6 0.0 6.3e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESS63657.1 - 0.00017 20.9 0.1 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 1 NatB_MDM20 PF09797.4 ESS63658.1 - 5.6e-76 255.6 0.4 8.3e-76 255.0 0.3 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.1 ESS63658.1 - 3e-08 33.8 10.5 4e-05 23.8 3.5 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63658.1 - 0.0012 19.2 12.1 0.015 15.8 0.3 5.0 4 1 0 4 4 4 1 Tetratricopeptide repeat DUF4096 PF13340.1 ESS63658.1 - 0.081 12.7 0.1 0.54 10.1 0.0 2.4 2 0 0 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) TPR_16 PF13432.1 ESS63658.1 - 0.11 13.2 10.7 0.089 13.4 2.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63658.1 - 4.5 7.7 6.7 2.2 8.7 0.2 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat LRR_4 PF12799.2 ESS63659.1 - 5.8e-11 41.7 0.2 1.1e-05 24.8 0.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS63659.1 - 1.4e-06 27.9 0.0 0.0014 18.3 0.0 3.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_7 PF13504.1 ESS63659.1 - 7.3e-06 25.3 1.4 0.094 12.9 0.3 4.5 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 ESS63659.1 - 0.00011 21.7 1.6 0.15 12.1 0.1 3.9 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS63659.1 - 0.0016 18.3 3.0 4.1 7.7 0.4 4.4 5 0 0 5 5 5 2 Leucine Rich repeat SAM_1 PF00536.25 ESS63660.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 ESS63660.1 - 0.039 13.7 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain IpaD PF06511.6 ESS63661.1 - 0.71 8.8 2.7 1.1 8.1 1.9 1.2 1 0 0 1 1 1 0 Invasion plasmid antigen IpaD Med9 PF07544.8 ESS63662.1 - 0.44 10.3 23.1 0.28 10.9 1.6 4.2 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF3552 PF12072.3 ESS63662.1 - 3.1 6.9 38.1 0.029 13.5 10.8 3.6 1 1 1 3 3 3 0 Domain of unknown function (DUF3552) Bystin PF05291.6 ESS63663.1 - 5.4e-108 360.4 0.2 7.9e-108 359.9 0.1 1.1 1 0 0 1 1 1 1 Bystin DUF1173 PF06666.6 ESS63664.1 - 0.056 12.2 0.0 0.094 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) DUF643 PF04867.7 ESS63664.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF643) tRNA-synt_2 PF00152.15 ESS63665.1 - 2.4e-72 243.5 0.0 3.3e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESS63665.1 - 1.9e-10 40.4 0.1 1.7e-09 37.4 0.1 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESS63665.1 - 0.00036 19.7 0.1 0.094 11.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DUF2058 PF09831.4 ESS63665.1 - 0.011 15.6 2.4 0.017 14.9 1.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) IpaC_SipC PF09599.5 ESS63665.1 - 0.93 8.4 13.1 1.5 7.8 9.1 1.2 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) HA2 PF04408.18 ESS63666.1 - 6.9e-25 87.0 0.0 1.2e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESS63666.1 - 1e-17 63.9 0.0 1.9e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESS63666.1 - 2.6e-14 52.8 0.0 6.2e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS63666.1 - 1.4e-07 31.1 0.1 4.4e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS63666.1 - 8.8e-06 25.8 0.0 2.9e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS63666.1 - 0.00076 18.4 0.0 0.0015 17.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 ESS63666.1 - 0.013 15.3 0.0 5.7 6.7 0.0 2.7 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit ABC_tran PF00005.22 ESS63666.1 - 0.025 14.8 0.1 0.7 10.1 0.0 2.4 1 1 1 2 2 2 0 ABC transporter SRP54 PF00448.17 ESS63666.1 - 0.034 13.5 0.0 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_29 PF13555.1 ESS63666.1 - 0.063 12.8 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 ESS63666.1 - 0.068 12.9 0.1 0.52 10.0 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain AAA_30 PF13604.1 ESS63666.1 - 0.1 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 ESS63666.1 - 0.12 12.3 0.0 0.55 10.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.1 ESS63666.1 - 0.14 11.5 0.0 0.52 9.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 ESS63666.1 - 0.15 11.6 0.0 0.4 10.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Choline_kinase PF01633.15 ESS63667.1 - 1.6e-29 103.0 0.0 6.2e-29 101.0 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESS63667.1 - 9.9e-14 51.6 0.0 1.3e-10 41.4 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family Turandot PF07240.6 ESS63670.1 - 0.036 13.5 3.1 4.8 6.7 0.0 2.9 3 0 0 3 3 3 0 Stress-inducible humoral factor Turandot RLL PF10036.4 ESS63670.1 - 0.064 12.6 1.9 0.19 11.1 0.1 2.1 2 0 0 2 2 2 0 Putative carnitine deficiency-associated protein CECR6_TMEM121 PF14997.1 ESS63671.1 - 3.2e-05 23.6 1.8 3.2e-05 23.6 1.2 2.7 2 1 1 3 3 3 1 CECR6/TMEM121 family DUF4227 PF14004.1 ESS63671.1 - 0.0089 15.8 0.2 0.038 13.8 0.1 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4227) HALZ PF02183.13 ESS63672.1 - 0.016 14.9 10.9 1.4 8.6 0.2 4.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper DivIC PF04977.10 ESS63672.1 - 0.034 13.6 10.3 0.14 11.6 1.7 3.5 3 0 0 3 3 3 0 Septum formation initiator Prefoldin PF02996.12 ESS63672.1 - 0.05 13.2 3.1 0.36 10.5 0.1 3.4 3 1 2 5 5 5 0 Prefoldin subunit bZIP_1 PF00170.16 ESS63672.1 - 0.14 12.1 14.0 6.9 6.7 0.1 4.6 3 1 1 4 4 4 0 bZIP transcription factor TPR_MLP1_2 PF07926.7 ESS63672.1 - 0.15 11.7 11.1 0.27 10.9 6.7 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 ESS63672.1 - 0.48 10.0 14.0 0.055 13.1 5.3 2.7 2 2 2 4 4 4 0 Mnd1 family DUF342 PF03961.8 ESS63672.1 - 0.65 8.3 7.8 0.45 8.8 1.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF342) FadA PF09403.5 ESS63672.1 - 1.1 9.3 7.9 2.3 8.2 2.5 2.7 2 0 0 2 2 2 0 Adhesion protein FadA TPD52 PF04201.10 ESS63672.1 - 1.8 8.2 10.4 4.2 7.0 1.6 2.9 2 1 1 3 3 3 0 Tumour protein D52 family COG5 PF10392.4 ESS63672.1 - 2.6 8.0 8.1 18 5.3 1.1 3.6 3 1 0 3 3 3 0 Golgi transport complex subunit 5 TMF_DNA_bd PF12329.3 ESS63672.1 - 5.7 6.8 12.6 1 9.2 3.1 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.14 ESS63672.1 - 6.8 4.4 6.0 9.7 3.8 4.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF972 PF06156.8 ESS63672.1 - 9 6.6 15.4 11 6.3 2.2 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF972) Atg14 PF10186.4 ESS63673.1 - 0.088 11.7 9.0 0.63 8.9 1.1 2.5 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 ADIP PF11559.3 ESS63673.1 - 0.099 12.5 12.5 0.22 11.4 1.3 2.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Bacillus_HBL PF05791.6 ESS63673.1 - 0.1 11.9 3.4 0.14 11.5 0.6 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Cortex-I_coil PF09304.5 ESS63673.1 - 0.13 12.3 13.9 0.69 9.9 0.9 3.3 3 0 0 3 3 3 0 Cortexillin I, coiled coil Rop-like PF05082.8 ESS63673.1 - 0.29 10.6 2.1 32 4.0 0.0 3.4 3 0 0 3 3 3 0 Rop-like DUF1664 PF07889.7 ESS63673.1 - 0.33 10.7 5.6 1.8 8.4 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CDC37_N PF03234.9 ESS63673.1 - 0.34 11.2 7.3 0.16 12.2 0.9 2.7 2 1 1 3 3 3 0 Cdc37 N terminal kinase binding SlyX PF04102.7 ESS63673.1 - 0.41 11.0 8.8 1.8 8.9 0.5 3.5 2 1 1 3 3 3 0 SlyX V_ATPase_I PF01496.14 ESS63673.1 - 0.72 7.6 4.0 1.1 7.0 2.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin-6_N PF09177.6 ESS63673.1 - 2 8.9 6.8 3.2 8.2 0.2 3.6 3 0 0 3 3 3 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.7 ESS63673.1 - 2.8 7.6 10.2 3.8 7.2 1.4 3.0 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.3 ESS63673.1 - 8.1 6.3 16.5 0.24 11.2 2.6 3.5 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding TPR_11 PF13414.1 ESS63674.1 - 9e-24 82.9 17.2 3.5e-13 48.9 0.8 4.7 4 1 1 5 5 5 4 TPR repeat TPR_17 PF13431.1 ESS63674.1 - 2.2e-18 64.8 5.7 0.0011 19.0 0.0 6.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESS63674.1 - 2.1e-17 61.9 5.9 3.2e-06 26.4 0.1 5.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESS63674.1 - 2.8e-17 62.9 12.5 7.1e-06 26.5 0.1 5.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS63674.1 - 1e-15 56.2 12.9 2.7e-05 23.7 0.1 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63674.1 - 2.4e-14 53.0 2.6 1.1e-07 31.6 0.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63674.1 - 4.8e-12 45.3 22.1 0.0036 17.8 0.0 7.9 5 1 3 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS63674.1 - 2.9e-09 37.1 13.0 0.0011 19.2 0.1 5.4 3 3 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63674.1 - 6.8e-08 31.7 0.4 0.044 13.5 0.0 5.1 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS63674.1 - 3.7e-05 23.1 3.0 4.8 7.2 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS63674.1 - 0.00047 19.9 10.9 0.0053 16.5 0.6 4.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63674.1 - 0.00097 19.4 7.8 8.3 7.1 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESS63674.1 - 0.0019 17.4 0.1 0.0084 15.3 0.0 2.2 2 0 0 2 2 2 1 SHNi-TPR TPR_10 PF13374.1 ESS63674.1 - 2.9 7.9 12.3 0.62 10.0 0.2 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESS63674.1 - 7.1 6.8 17.0 11 6.2 0.1 5.6 4 2 3 7 7 7 0 Tetratricopeptide repeat tRNA-synt_2b PF00587.20 ESS63675.1 - 1.8e-42 144.8 0.7 3e-42 144.1 0.5 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESS63675.1 - 2.8e-18 65.6 0.2 8.2e-18 64.1 0.2 1.8 2 0 0 2 2 2 1 Anticodon binding domain TGS PF02824.16 ESS63675.1 - 9.1e-13 47.8 0.0 1.9e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.9 ESS63675.1 - 1.6e-11 43.8 0.0 2.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain RRM_1 PF00076.17 ESS63676.1 - 1.6e-05 24.3 0.2 0.13 11.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS63676.1 - 0.00019 21.2 0.0 0.00048 19.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS63676.1 - 0.00022 21.1 0.1 0.00078 19.3 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESS63676.1 - 0.0091 15.7 0.2 0.024 14.3 0.1 1.7 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF3157 PF11355.3 ESS63676.1 - 0.041 13.1 0.1 0.21 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3157) OTU PF02338.14 ESS63677.1 - 2.1e-15 57.3 1.4 3.7e-15 56.5 0.1 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ESS63677.1 - 0.0023 17.3 0.0 0.089 12.1 0.0 2.2 2 0 0 2 2 2 1 Peptidase C65 Otubain DZR PF12773.2 ESS63677.1 - 0.021 14.6 32.6 0.082 12.7 8.8 3.3 3 1 0 3 3 3 0 Double zinc ribbon zf-RanBP PF00641.13 ESS63677.1 - 0.11 11.6 28.7 0.093 11.8 3.0 4.5 3 1 1 4 4 4 0 Zn-finger in Ran binding protein and others zf-tcix PF14952.1 ESS63677.1 - 0.22 10.8 0.1 0.22 10.8 0.0 3.3 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.1 ESS63677.1 - 0.34 10.1 23.9 0.017 14.3 2.3 4.0 4 0 0 4 4 4 0 zinc-ribbon domain Peptidase_M16_C PF05193.16 ESS63678.1 - 9.6e-17 61.2 0.0 2.2e-16 60.0 0.0 1.6 1 1 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ESS63678.1 - 5.7e-07 29.4 0.0 1.1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Herpes_IE68 PF02479.11 ESS63679.1 - 0.026 13.7 0.1 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus immediate early protein Thioredoxin PF00085.15 ESS63680.1 - 2.6e-15 55.9 0.0 5.2e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 ESS63680.1 - 6.4e-05 23.1 0.0 0.0006 19.9 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESS63680.1 - 0.00035 20.6 0.0 0.056 13.5 0.1 3.2 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.1 ESS63680.1 - 0.011 15.7 0.1 0.041 13.9 0.1 1.9 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_6 PF13848.1 ESS63680.1 - 0.013 15.2 0.0 0.77 9.5 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like domain HyaE PF07449.6 ESS63680.1 - 0.12 12.2 0.0 0.35 10.7 0.0 1.8 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Ala_racemase_N PF01168.15 ESS63682.1 - 3.5e-33 114.9 0.0 4.8e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.16 ESS63682.1 - 1.8e-25 88.8 0.1 2.8e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain Phage_GP20 PF06810.6 ESS63683.1 - 0.01 15.3 3.2 0.01 15.3 2.2 3.7 3 2 1 4 4 4 1 Phage minor structural protein GP20 FlaC_arch PF05377.6 ESS63683.1 - 0.61 10.0 6.0 12 5.9 0.1 4.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.7 ESS63683.1 - 3.3 7.5 10.9 25 4.7 0.1 4.2 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 ESS63683.1 - 3.8 7.3 7.0 2.6 7.8 0.4 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) 2OG-FeII_Oxy_2 PF13532.1 ESS63684.1 - 1.2e-12 48.0 0.0 1.8e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESS63684.1 - 6.6e-07 29.5 0.0 2e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 ESS63684.1 - 0.073 13.5 0.0 0.47 11.0 0.0 2.3 2 1 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily AAA PF00004.24 ESS63685.1 - 1e-05 25.7 0.0 1.6e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESS63685.1 - 0.015 15.1 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain RNase_H PF00075.19 ESS63686.1 - 2e-13 50.8 0.0 2.9e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS63686.1 - 0.15 11.4 0.1 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 DAN domain zf-C2H2_jaz PF12171.3 ESS63686.1 - 0.2 11.8 3.7 7.5 6.8 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESS63686.1 - 2.7 8.5 16.5 1.4 9.4 1.2 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type RHSP PF07999.6 ESS63689.1 - 1.8e-43 148.7 0.0 3.1e-43 148.0 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein Laminin_G_3 PF13385.1 ESS63691.1 - 1.8e-16 60.7 2.1 2.1e-16 60.5 0.4 1.8 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63691.1 - 1.5e-12 47.1 12.0 3e-12 46.1 8.3 1.6 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS63692.1 - 6.7e-131 435.9 3.7 8.4e-131 435.6 2.6 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS63694.1 - 8.9e-131 435.5 7.6 1.6e-130 434.7 5.3 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63694.1 - 8.9e-10 39.0 0.2 2.5e-09 37.5 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63695.1 - 3e-12 46.1 11.1 4.9e-12 45.5 7.7 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal COPR5 PF15340.1 ESS63695.1 - 0.4 11.0 3.2 0.78 10.0 2.2 1.5 1 1 0 1 1 1 0 Cooperator of PRMT5 family mono-CXXC PF15626.1 ESS63695.1 - 9.1 6.3 6.5 10 6.1 1.9 2.3 2 1 0 2 2 2 0 single CXXC unit DUF3720 PF12517.3 ESS63697.1 - 3e-17 63.1 15.8 3e-17 63.1 10.9 4.0 1 1 4 5 5 5 1 Protein of unknown function (DUF3720) BNR_3 PF13859.1 ESS63698.1 - 2.9e-130 433.8 3.2 4.9e-130 433.1 2.2 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63698.1 - 1.2e-16 61.2 0.7 4.4e-16 59.4 0.5 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63698.1 - 4.8e-09 35.9 12.2 4.8e-09 35.9 8.5 2.0 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_2 PF13088.1 ESS63698.1 - 0.00035 19.9 0.0 0.016 14.5 0.0 2.5 2 1 1 3 3 3 2 BNR repeat-like domain DUF3728 PF12528.3 ESS63699.1 - 1.4 9.3 8.6 3.4 8.1 1.1 3.1 3 1 0 3 3 3 0 Prepilin peptidase dependent protein C (DUF3728) MAP65_ASE1 PF03999.7 ESS63702.1 - 1.7 7.1 9.4 2.2 6.7 6.5 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Peptidase_M8 PF01457.11 ESS63707.1 - 3.1e-07 29.1 6.1 1.5e-05 23.5 4.2 2.1 1 1 0 1 1 1 1 Leishmanolysin BNR_3 PF13859.1 ESS63708.1 - 2.5e-131 437.3 4.6 5e-131 436.3 3.2 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS63708.1 - 5.3e-19 68.9 2.0 1.5e-18 67.5 0.1 2.4 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS63708.1 - 1.1e-07 31.6 12.6 1.1e-07 31.6 8.7 2.1 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal PTPlike_phytase PF14566.1 ESS63708.1 - 0.12 12.3 0.2 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Mucin PF01456.12 ESS63709.1 - 1.3e-30 106.0 47.3 2.5e-29 101.9 32.8 2.3 1 1 0 1 1 1 1 Mucin-like glycoprotein Herpes_UL32 PF06070.6 ESS63709.1 - 2.4 6.5 17.8 2.8 6.2 12.3 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 MAP65_ASE1 PF03999.7 ESS63709.1 - 8.9 4.7 10.9 11 4.4 7.6 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Phage_integrase PF00589.17 ESS63711.1 - 0.00066 19.3 0.4 0.0013 18.4 0.3 1.7 1 1 0 1 1 1 1 Phage integrase family HSP70 PF00012.15 ESS63712.1 - 7.1e-260 863.0 13.1 8.1e-260 862.9 9.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESS63712.1 - 9e-20 70.5 0.7 6.5e-17 61.1 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 ESS63712.1 - 0.00043 19.9 0.0 0.0017 18.0 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 ESS63712.1 - 0.00044 19.4 3.1 0.0017 17.4 0.0 2.9 2 1 1 3 3 3 1 Hydantoinase/oxoprolinase SpoIIAA-like PF11964.3 ESS63712.1 - 0.2 11.9 1.7 0.92 9.8 0.2 2.8 2 2 1 3 3 3 0 SpoIIAA-like RRM_6 PF14259.1 ESS63714.1 - 0.041 13.8 0.1 9.4 6.2 0.0 3.0 3 0 0 3 3 3 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Flavodoxin_1 PF00258.20 ESS63715.1 - 3.1e-34 118.0 0.0 4.6e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.15 ESS63715.1 - 1.2e-31 109.9 0.0 1.9e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_NdrI PF07972.6 ESS63715.1 - 0.013 15.4 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 NrdI Flavodoxin like TarH PF02203.10 ESS63715.1 - 0.16 11.7 0.0 11 5.8 0.0 2.2 2 0 0 2 2 2 0 Tar ligand binding domain homologue EF-hand_8 PF13833.1 ESS63716.1 - 0.022 14.3 0.1 0.076 12.6 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair Fmp27_WPPW PF10359.4 ESS63716.1 - 0.37 9.1 9.3 0.53 8.6 6.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain IncA PF04156.9 ESS63716.1 - 0.38 10.3 13.5 0.56 9.7 9.4 1.2 1 0 0 1 1 1 0 IncA protein DUF342 PF03961.8 ESS63716.1 - 0.67 8.3 6.6 0.92 7.8 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 ESS63716.1 - 1.6 6.4 7.1 1.9 6.2 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ESS63716.1 - 2.3 7.1 11.9 3.3 6.6 8.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 ADIP PF11559.3 ESS63716.1 - 3.4 7.5 18.9 5.7 6.8 13.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding EssA PF10661.4 ESS63716.1 - 4.9 6.8 8.8 9.9 5.8 6.1 1.5 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA CDC37_N PF03234.9 ESS63716.1 - 6 7.1 9.6 10 6.3 6.6 1.4 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Atg14 PF10186.4 ESS63716.1 - 9.5 5.0 11.6 12 4.7 8.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Ribonuclease_3 PF00636.21 ESS63717.1 - 0.0007 20.0 0.0 0.0018 18.6 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease III domain WCCH PF03716.9 ESS63718.1 - 0.099 12.1 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 WCCH motif TFIIA PF03153.8 ESS63720.1 - 1.8 8.3 7.9 2.4 7.9 5.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hydrolase_3 PF08282.7 ESS63721.1 - 2.2e-54 184.7 0.0 2.5e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 ESS63721.1 - 4.1e-13 49.1 0.1 1.6e-06 27.6 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.21 ESS63721.1 - 1.8e-09 38.3 0.2 3.6e-08 34.0 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS63721.1 - 3.4e-05 24.0 0.4 0.0037 17.4 0.3 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 ESS63721.1 - 0.002 17.9 0.0 0.0049 16.7 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.9 ESS63721.1 - 0.067 12.5 0.2 4.1 6.7 0.0 2.5 1 1 1 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) zf-CCCH PF00642.19 ESS63722.1 - 0.00074 19.1 9.3 0.0014 18.2 6.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) IMS_C PF11799.3 ESS63723.1 - 1.2e-14 54.3 1.1 1.9e-14 53.6 0.7 1.2 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Myosin_tail_1 PF01576.14 ESS63723.1 - 0.086 10.5 1.2 0.1 10.3 0.9 1.0 1 0 0 1 1 1 0 Myosin tail TMF_DNA_bd PF12329.3 ESS63724.1 - 0.025 14.3 4.4 0.12 12.1 1.9 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Syntaxin-6_N PF09177.6 ESS63724.1 - 2 8.8 5.0 3.4 8.1 0.5 3.2 4 0 0 4 4 4 0 Syntaxin 6, N-terminal IMS PF00817.15 ESS63725.1 - 1.5e-13 50.8 0.0 2.2e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.3 ESS63725.1 - 0.0015 18.4 0.0 0.0035 17.2 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif DUF2762 PF10960.3 ESS63725.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) Beta-APP PF03494.8 ESS63728.1 - 0.009 15.4 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) ADIP PF11559.3 ESS63729.1 - 0.0046 16.8 8.6 0.0046 16.8 6.0 5.8 3 1 2 6 6 6 2 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.3 ESS63729.1 - 0.012 15.3 1.6 0.012 15.3 1.1 5.7 6 0 0 6 6 6 0 TATA element modulatory factor 1 DNA binding DEAD PF00270.24 ESS63730.1 - 1.9e-40 138.1 0.1 5.8e-38 130.0 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS63730.1 - 5.3e-29 99.8 0.0 1.2e-28 98.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 ESS63730.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain CMS1 PF14617.1 ESS63730.1 - 0.002 17.2 0.0 0.0038 16.3 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit SNARE PF05739.14 ESS63734.1 - 5.8e-15 54.7 0.5 5.8e-15 54.7 0.3 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESS63734.1 - 1.3e-07 31.7 1.5 1.3e-07 31.7 1.0 2.6 1 1 0 2 2 2 1 Syntaxin MCPsignal PF00015.16 ESS63734.1 - 0.0013 18.3 11.5 0.037 13.5 3.5 2.3 2 0 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain CCP_MauG PF03150.9 ESS63734.1 - 0.0029 17.9 2.7 0.0029 17.9 1.9 1.9 1 1 1 2 2 2 1 Di-haem cytochrome c peroxidase Prominin PF05478.6 ESS63734.1 - 0.016 12.7 7.4 0.023 12.2 5.1 1.2 1 0 0 1 1 1 0 Prominin Herpes_US9 PF06072.6 ESS63734.1 - 0.016 14.9 0.8 0.016 14.9 0.6 2.0 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 AAA_13 PF13166.1 ESS63734.1 - 0.19 10.1 15.0 0.022 13.2 5.1 2.0 1 1 1 2 2 2 0 AAA domain Sec20 PF03908.8 ESS63734.1 - 0.67 9.6 9.4 0.27 10.9 1.0 3.2 2 1 1 3 3 3 0 Sec20 DUF2951 PF11166.3 ESS63734.1 - 3 7.7 10.0 0.45 10.3 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2951) CoA_binding_3 PF13727.1 ESS63735.1 - 0.045 13.5 1.0 0.072 12.9 0.7 1.3 1 0 0 1 1 1 0 CoA-binding domain Coa1 PF08695.5 ESS63735.1 - 0.059 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 DUF1212 PF06738.7 ESS63735.1 - 0.23 10.8 6.8 0.35 10.3 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) DUF2293 PF10056.4 ESS63736.1 - 0.043 13.7 0.7 0.091 12.7 0.5 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) ABC_tran PF00005.22 ESS63737.1 - 7.3e-32 110.5 0.1 1.5e-31 109.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 ESS63737.1 - 8.6e-16 57.7 11.1 8.6e-16 57.7 7.7 2.5 3 0 0 3 3 3 1 ABC-2 type transporter AAA_21 PF13304.1 ESS63737.1 - 3.4e-07 30.5 0.1 0.0099 15.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESS63737.1 - 8.6e-05 22.5 0.1 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 ESS63737.1 - 0.00077 18.6 0.0 0.0021 17.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESS63737.1 - 0.0015 17.9 0.0 0.0031 16.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 ESS63737.1 - 0.0076 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS63737.1 - 0.0096 16.0 0.1 0.026 14.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 ESS63737.1 - 0.022 14.6 0.0 0.076 12.9 0.0 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 ESS63737.1 - 0.028 15.2 0.0 0.063 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESS63737.1 - 0.031 14.5 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESS63737.1 - 0.057 13.3 0.5 0.12 12.3 0.4 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESS63737.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 ESS63737.1 - 0.13 11.6 0.3 0.24 10.8 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 ESS63737.1 - 0.15 10.8 0.1 0.26 10.0 0.1 1.3 1 0 0 1 1 1 0 ArgK protein AAA_30 PF13604.1 ESS63737.1 - 0.22 11.0 0.0 0.41 10.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain FixQ PF05545.6 ESS63737.1 - 0.46 10.1 0.0 0.46 10.1 0.0 2.9 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ DUF2089 PF09862.4 ESS63738.1 - 0.0007 19.3 0.3 0.0027 17.5 0.2 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) Aldose_epim PF01263.15 ESS63739.1 - 7e-59 199.3 0.0 9.8e-59 198.8 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase FtsX PF02687.16 ESS63741.1 - 1.2e-18 66.9 36.7 1.7e-10 40.7 10.5 3.4 4 0 0 4 4 4 2 FtsX-like permease family CHAP PF05257.11 ESS63742.1 - 1.2e-14 54.0 0.1 1.8e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 CHAP domain ATG16 PF08614.6 ESS63743.1 - 0.036 13.8 1.7 0.052 13.3 1.2 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.7 ESS63743.1 - 0.06 13.5 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein CD52 PF15116.1 ESS63743.1 - 0.13 12.0 0.8 17 5.3 0.0 3.0 2 0 0 2 2 2 0 CAMPATH-1 antigen NTP_transferase PF00483.18 ESS63743.1 - 0.15 11.3 0.3 0.21 10.8 0.2 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase Reo_sigmaC PF04582.7 ESS63743.1 - 0.15 11.2 4.4 0.21 10.7 3.1 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Gp58 PF07902.6 ESS63743.1 - 0.68 8.0 2.9 0.94 7.6 2.0 1.1 1 0 0 1 1 1 0 gp58-like protein PLAC9 PF15205.1 ESS63744.1 - 1.7 8.9 6.5 2.1 8.6 0.2 4.2 4 0 0 4 4 4 0 Placenta-specific protein 9 AMPKBI PF04739.10 ESS63745.1 - 1.4e-17 63.3 0.0 2.5e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain 5_3_exonuc_N PF02739.11 ESS63745.1 - 0.091 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain Metallopep PF12044.3 ESS63745.1 - 0.12 10.8 0.0 0.34 9.2 0.0 1.7 2 0 0 2 2 2 0 Putative peptidase family ABC2_membrane_2 PF12679.2 ESS63746.1 - 2.7 6.7 8.2 3.1 6.5 5.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-DHHC PF01529.15 ESS63746.1 - 4.5 6.6 11.2 5.8 6.2 7.7 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase SET PF00856.23 ESS63747.1 - 6.4e-11 42.8 0.0 6e-10 39.6 0.0 2.0 1 1 0 1 1 1 1 SET domain RecR PF02132.10 ESS63747.1 - 0.067 12.6 0.2 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 RecR protein DUF678 PF05077.7 ESS63747.1 - 0.083 12.8 0.1 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF678) FtsJ PF01728.14 ESS63748.1 - 7.9e-49 166.0 0.1 9.2e-49 165.8 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 ESS63748.1 - 0.0005 19.8 0.0 0.00093 18.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS63748.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Arch_flagellin PF01917.11 ESS63749.1 - 2.3 7.8 4.3 4.9 6.7 3.0 1.5 1 0 0 1 1 1 0 Archaebacterial flagellin AMP-binding PF00501.23 ESS63750.1 - 4.4e-86 288.8 0.2 5.2e-86 288.6 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESS63750.1 - 9e-17 61.7 0.2 9e-17 61.7 0.1 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain EF-hand_6 PF13405.1 ESS63751.1 - 4.6e-09 35.4 0.4 2.2e-05 23.9 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 ESS63751.1 - 5.1e-08 31.6 0.8 0.00065 18.8 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 ESS63751.1 - 1.3e-05 25.1 5.2 1.4e-05 25.1 2.0 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS63751.1 - 4.1e-05 23.1 5.7 7.3e-05 22.3 0.2 3.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 ESS63751.1 - 5e-05 22.4 0.3 0.0014 17.8 0.0 2.5 2 0 0 2 2 2 1 EF hand GSP_synth PF03738.9 ESS63751.1 - 0.069 13.4 0.0 0.6 10.4 0.0 2.1 2 0 0 2 2 2 0 Glutathionylspermidine synthase preATP-grasp Fmp27 PF10344.4 ESS63751.1 - 0.13 9.8 0.1 0.19 9.3 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 XRN_N PF03159.13 ESS63752.1 - 4.7e-42 143.9 0.0 1.4e-21 76.9 0.0 2.4 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus DUF2401 PF10287.4 ESS63754.1 - 0.047 13.1 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative TOS1-like glycosyl hydrolase (DUF2401) WW PF00397.21 ESS63755.1 - 3.9e-23 80.9 19.1 7.9e-08 32.0 2.9 3.4 3 0 0 3 3 3 3 WW domain Hydrolase_2 PF07486.7 ESS63755.1 - 7.9 7.0 7.0 4.8 7.7 0.5 3.1 1 1 2 3 3 3 0 Cell Wall Hydrolase CAF1 PF04857.15 ESS63757.1 - 2.3e-50 171.3 0.0 3.4e-50 170.8 0.0 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Metallothio_2 PF01439.13 ESS63758.1 - 0.081 13.4 0.5 0.16 12.5 0.4 1.4 1 0 0 1 1 1 0 Metallothionein RHSP PF07999.6 ESS63760.1 - 1.4e-81 274.3 0.4 2.1e-81 273.7 0.2 1.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein NGP1NT PF08153.7 ESS63762.1 - 0.071 13.0 0.0 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 NGP1NT (NUC091) domain GFO_IDH_MocA PF01408.17 ESS63763.1 - 3e-14 53.5 0.2 5.7e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Arv1 PF04161.8 ESS63764.1 - 0.029 14.2 1.0 0.029 14.2 0.7 1.4 2 0 0 2 2 2 0 Arv1-like family GSP_synth PF03738.9 ESS63765.1 - 2.6e-24 85.2 0.1 4.7e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CHAP PF05257.11 ESS63765.1 - 9.3e-19 67.3 0.0 2.1e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 CHAP domain CP_ATPgrasp_2 PF14403.1 ESS63765.1 - 0.038 12.6 0.0 0.056 12.0 0.0 1.1 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 Baculo_gp64 PF03273.8 ESS63765.1 - 0.059 11.5 0.1 0.093 10.8 0.1 1.2 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family PUF PF00806.14 ESS63766.1 - 0.00072 18.8 0.0 6.1 6.5 0.0 5.0 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat Pkinase PF00069.20 ESS63767.1 - 5.3e-68 228.9 0.0 6.9e-68 228.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63767.1 - 4.5e-39 134.0 0.0 5.7e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63767.1 - 3.3e-06 26.2 0.0 1e-05 24.6 0.0 1.8 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESS63767.1 - 0.0018 18.0 0.1 0.028 14.1 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family VPS9 PF02204.13 ESS63768.1 - 1.3e-10 41.1 0.1 5.1e-10 39.3 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain MORN PF02493.15 ESS63768.1 - 8.4e-06 25.2 8.4 0.0052 16.4 0.2 5.0 4 0 0 4 4 4 2 MORN repeat MethyltransfD12 PF02086.10 ESS63768.1 - 0.034 13.6 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase CARDB PF07705.6 ESS63769.1 - 0.091 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 CARDB LRR_8 PF13855.1 ESS63770.1 - 5e-07 29.3 0.0 1.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 ESS63770.1 - 9.6e-07 28.2 0.5 0.0096 15.5 0.2 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) EF-hand_7 PF13499.1 ESS63770.1 - 1.2e-06 28.5 0.2 8.8e-06 25.7 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS63770.1 - 6.5e-06 25.6 0.0 0.0044 16.7 0.0 3.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESS63770.1 - 0.00022 20.3 0.0 0.0076 15.4 0.0 3.4 3 0 0 3 3 3 1 EF hand LRR_7 PF13504.1 ESS63770.1 - 0.00099 18.9 0.1 0.78 10.2 0.0 3.2 2 0 0 2 2 2 1 Leucine rich repeat EF-hand_9 PF14658.1 ESS63770.1 - 0.0021 17.9 0.0 0.028 14.3 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 ESS63770.1 - 0.0034 16.9 0.0 0.012 15.2 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair LRR_6 PF13516.1 ESS63770.1 - 0.0037 17.1 0.2 0.28 11.3 0.0 2.8 2 0 0 2 2 2 1 Leucine Rich repeat LRR_1 PF00560.28 ESS63770.1 - 0.012 15.4 0.1 6.4 7.2 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat Syntaxin-6_N PF09177.6 ESS63770.1 - 0.053 13.9 3.4 0.41 11.0 0.1 3.3 3 0 0 3 3 3 0 Syntaxin 6, N-terminal ADIP PF11559.3 ESS63770.1 - 1.3 8.9 6.7 0.061 13.2 0.4 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Ax_dynein_light PF10211.4 ESS63770.1 - 1.4 8.7 9.4 0.044 13.6 1.4 2.4 2 1 0 2 2 1 0 Axonemal dynein light chain bZIP_2 PF07716.10 ESS63770.1 - 8.6 6.2 8.3 0.91 9.3 2.3 2.0 2 0 0 2 2 2 0 Basic region leucine zipper Pex2_Pex12 PF04757.9 ESS63771.1 - 5.7e-19 68.4 3.7 6.4e-12 45.3 0.0 2.2 1 1 1 2 2 2 2 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 ESS63771.1 - 2.2e-09 37.1 9.4 3.4e-09 36.5 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS63771.1 - 2.4e-09 36.8 8.3 3.9e-09 36.2 5.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESS63771.1 - 1.7e-08 34.0 5.8 2.7e-08 33.3 4.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS63771.1 - 3.2e-08 33.1 6.7 5.3e-08 32.4 4.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESS63771.1 - 1.4e-07 31.0 8.1 2.1e-07 30.4 5.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS63771.1 - 1.2e-06 28.2 7.3 1.9e-06 27.6 5.1 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 ESS63771.1 - 0.00013 21.7 3.3 0.00022 20.9 2.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESS63771.1 - 0.00025 21.1 5.1 0.0004 20.4 3.6 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 ESS63771.1 - 0.0019 17.8 2.5 0.0052 16.4 1.7 1.8 1 1 0 1 1 1 1 RING-type zinc-finger TerY-C PF15616.1 ESS63771.1 - 0.0094 15.8 0.4 0.015 15.2 0.3 1.2 1 0 0 1 1 1 1 TerY-C metal binding domain zf-RING_4 PF14570.1 ESS63771.1 - 0.043 13.3 5.7 0.094 12.3 4.0 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 ESS63771.1 - 0.049 13.1 1.4 0.083 12.4 1.0 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.1 ESS63771.1 - 0.1 12.3 3.6 0.19 11.5 2.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.1 ESS63771.1 - 0.1 12.1 6.7 0.37 10.3 4.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.3 ESS63771.1 - 0.34 10.8 7.6 2.5 8.1 5.3 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain IBR PF01485.16 ESS63771.1 - 0.98 9.3 7.4 0.86 9.5 4.0 1.8 1 1 0 1 1 1 0 IBR domain zf-DHHC PF01529.15 ESS63772.1 - 7.5e-38 129.6 1.3 7.5e-38 129.6 0.9 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Pex2_Pex12 PF04757.9 ESS63775.1 - 8e-33 113.7 8.3 1e-32 113.4 5.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.20 ESS63775.1 - 0.029 14.0 10.6 0.048 13.3 7.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 ESS63775.1 - 0.089 12.3 4.4 0.2 11.2 3.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.1 ESS63775.1 - 0.094 12.7 9.2 0.21 11.6 6.4 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS63775.1 - 0.24 11.1 10.4 0.42 10.3 7.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESS63775.1 - 0.33 10.6 8.5 0.51 10.0 5.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS63775.1 - 0.61 10.0 9.6 2.4 8.0 6.9 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Fib_alpha PF08702.5 ESS63776.1 - 0.53 10.3 5.4 0.25 11.4 0.7 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family COG2 PF06148.6 ESS63776.1 - 0.98 9.2 9.5 4.4 7.1 1.7 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 His_Phos_2 PF00328.17 ESS63777.1 - 1.3e-12 47.7 0.4 9.5e-05 21.8 0.5 3.0 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) ATP-gua_PtransN PF02807.10 ESS63777.1 - 0.0037 17.3 0.0 0.0072 16.4 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain PCI PF01399.22 ESS63778.1 - 5.6e-16 58.7 0.8 1.4e-15 57.4 0.1 2.0 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 ESS63778.1 - 0.0029 17.3 0.0 0.0079 15.9 0.0 1.7 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 ParcG PF10274.4 ESS63779.1 - 1.1e-77 260.0 0.0 1.4e-77 259.7 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein DnaJ PF00226.26 ESS63780.1 - 2e-22 78.6 0.5 5.5e-22 77.2 0.4 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.3 ESS63780.1 - 1.6e-06 28.0 4.3 3.5e-06 27.0 3.0 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESS63780.1 - 3.3e-05 23.9 2.0 6.1e-05 23.0 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESS63780.1 - 0.0031 17.5 1.0 0.0077 16.3 0.1 2.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Mitofilin PF09731.4 ESS63780.1 - 0.012 14.3 7.9 0.018 13.7 5.4 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1848 PF08902.6 ESS63780.1 - 0.039 13.4 0.9 0.06 12.8 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) zf-C2H2 PF00096.21 ESS63780.1 - 0.066 13.5 0.5 0.15 12.4 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type ARGLU PF15346.1 ESS63780.1 - 0.069 12.9 25.8 0.12 12.1 17.9 1.3 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Med8 PF10232.4 ESS63780.1 - 0.11 11.9 7.9 0.23 10.9 5.5 1.5 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 OTT_1508_deam PF14441.1 ESS63780.1 - 0.22 11.3 2.3 0.63 9.8 1.4 2.0 1 1 0 1 1 1 0 OTT_1508-like deaminase Sec1 PF00995.18 ESS63781.1 - 2.2e-86 290.7 0.0 2.6e-86 290.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family MobB PF03205.9 ESS63782.1 - 0.0083 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B BRO1 PF03097.13 ESS63783.1 - 7.3e-19 67.7 4.3 8.8e-19 67.4 3.0 1.1 1 0 0 1 1 1 1 BRO1-like domain EST1 PF10374.4 ESS63783.1 - 0.46 10.4 4.1 0.85 9.6 0.7 2.5 1 1 1 2 2 2 0 Telomerase activating protein Est1 CoA_binding PF02629.14 ESS63784.1 - 9.4e-29 99.7 3.4 1.1e-28 99.6 1.2 1.9 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 ESS63784.1 - 1.3e-18 67.0 0.2 2.8e-18 65.9 0.1 1.5 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 ESS63784.1 - 1.8e-06 27.5 0.0 3.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 ESS63784.1 - 6.4e-06 26.3 0.1 2.6e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 CoA binding domain KBP_C PF12309.3 ESS63785.1 - 2e-102 342.9 0.0 4.3e-102 341.8 0.0 1.6 2 0 0 2 2 2 1 KIF-1 binding protein C terminal SNARE PF05739.14 ESS63786.1 - 3.5e-06 26.6 1.1 7.5e-06 25.5 0.3 1.9 2 0 0 2 2 2 1 SNARE domain V-SNARE_C PF12352.3 ESS63786.1 - 0.042 13.9 0.4 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DUF2321 PF10083.4 ESS63786.1 - 0.11 12.0 0.2 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Syntaxin PF00804.20 ESS63786.1 - 0.43 10.7 5.5 0.25 11.5 0.1 2.3 2 1 0 2 2 2 0 Syntaxin Snapin_Pallidin PF14712.1 ESS63786.1 - 0.5 10.6 5.2 0.21 11.9 0.4 2.5 2 1 1 3 3 3 0 Snapin/Pallidin PEARLI-4 PF05278.7 ESS63786.1 - 2 7.6 8.5 0.065 12.5 1.0 1.9 2 1 1 3 3 3 0 Arabidopsis phospholipase-like protein (PEARLI 4) TBCA PF02970.11 ESS63786.1 - 4.1 7.5 9.0 0.43 10.6 1.5 2.7 2 2 1 3 3 3 0 Tubulin binding cofactor A TPR_11 PF13414.1 ESS63787.1 - 5.1e-29 99.7 24.5 8.1e-12 44.6 4.0 4.5 2 2 3 5 5 5 5 TPR repeat TPR_2 PF07719.12 ESS63787.1 - 1.4e-23 80.7 12.9 1.7e-06 27.4 0.1 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESS63787.1 - 1.8e-22 77.9 10.2 7.2e-07 28.5 0.0 5.6 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63787.1 - 7.6e-15 54.6 12.5 1.2e-06 28.2 0.2 4.9 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63787.1 - 2.1e-14 52.6 9.7 0.00071 19.9 0.0 5.5 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS63787.1 - 7.7e-12 45.3 5.6 3.4e-06 27.2 2.8 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63787.1 - 5.5e-11 41.4 0.8 0.031 14.0 0.0 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESS63787.1 - 6.4e-10 39.4 8.2 0.00029 21.4 0.3 4.4 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63787.1 - 1.2e-06 28.2 10.2 0.0073 16.4 0.2 6.1 8 0 0 8 8 6 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS63787.1 - 2.6e-05 24.2 11.5 0.00099 19.1 1.5 3.4 3 1 0 3 3 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESS63787.1 - 6.6e-05 23.1 3.4 0.35 11.4 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS63787.1 - 7e-05 22.5 6.2 0.044 13.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS63787.1 - 0.0024 17.5 10.2 0.23 11.3 0.2 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat Apc5 PF12862.2 ESS63787.1 - 0.01 15.6 0.4 0.01 15.6 0.3 2.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 MAS20 PF02064.10 ESS63787.1 - 0.026 14.4 1.0 0.21 11.4 0.0 2.7 2 1 1 3 3 3 0 MAS20 protein import receptor TPR_20 PF14561.1 ESS63787.1 - 0.039 14.0 8.1 5.4 7.2 0.8 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat Fe-S_assembly PF04384.8 ESS63787.1 - 0.085 13.2 0.9 1.4 9.3 0.3 2.3 2 0 0 2 2 2 0 Iron-sulphur cluster assembly BTAD PF03704.12 ESS63787.1 - 0.12 12.6 13.3 2.5 8.3 0.9 3.6 2 2 0 2 2 2 0 Bacterial transcriptional activator domain zf-CCHC PF00098.18 ESS63787.1 - 1.3 9.0 6.2 0.29 11.1 1.5 2.0 2 0 0 2 2 2 0 Zinc knuckle TPR_10 PF13374.1 ESS63787.1 - 4.4 7.3 15.2 3.7 7.6 0.4 4.3 6 0 0 6 6 4 0 Tetratricopeptide repeat Adeno_VII PF03228.9 ESS63787.1 - 4.7 7.8 6.9 0.47 11.0 0.5 2.5 2 2 0 2 2 2 0 Adenoviral core protein VII mRNA_triPase PF02940.10 ESS63788.1 - 8.1e-33 113.9 0.0 9.8e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain DUF3662 PF12401.3 ESS63788.1 - 0.0066 16.5 0.1 1.3 9.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2662) DUF3756 PF12581.3 ESS63788.1 - 0.016 14.8 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) RNase_H PF00075.19 ESS63790.1 - 0.045 14.0 0.0 0.068 13.5 0.0 1.2 1 0 0 1 1 1 0 RNase H HEAT PF02985.17 ESS63792.1 - 0.11 12.6 1.2 85 3.6 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat HEXIM PF15313.1 ESS63793.1 - 0.054 13.6 1.0 0.16 12.1 0.7 1.9 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein NAD_binding_5 PF07994.7 ESS63794.1 - 9.3e-107 356.9 0.0 1.1e-106 356.6 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 ESS63794.1 - 1.8e-45 153.3 0.0 3.3e-45 152.4 0.0 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase HECT PF00632.20 ESS63794.1 - 0.031 13.4 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) FA_desaturase PF00487.19 ESS63795.1 - 1.4e-16 60.7 9.8 1.4e-16 60.7 6.8 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 ESS63795.1 - 5.1e-07 29.3 0.0 9.5e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DEAD PF00270.24 ESS63796.1 - 2.3e-26 92.3 0.1 5.2e-26 91.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS63796.1 - 3.4e-16 58.8 0.0 7.3e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESS63796.1 - 0.0048 15.7 0.0 0.0067 15.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C_2 PF13307.1 ESS63796.1 - 0.055 13.4 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Helicase C-terminal domain Nic96 PF04097.9 ESS63797.1 - 3.6e-117 392.0 0.0 5.2e-117 391.5 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Paxillin PF03535.8 ESS63797.1 - 0.047 13.4 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Paxillin family WD40 PF00400.27 ESS63798.1 - 6.4e-24 82.9 18.3 7.5e-07 28.8 0.3 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ESS63798.1 - 0.00064 19.4 0.0 5.3 6.7 0.0 3.8 3 1 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A DUF2937 PF11157.3 ESS63799.1 - 0.044 13.1 0.2 0.073 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) F-box-like PF12937.2 ESS63800.1 - 5.3e-05 22.8 1.4 0.0001 21.9 1.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESS63800.1 - 0.0013 18.3 2.0 0.0029 17.2 1.1 1.8 1 1 1 2 2 2 1 F-box domain His_Phos_2 PF00328.17 ESS63802.1 - 3.7e-16 59.3 0.0 7.6e-12 45.2 0.0 2.3 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) PCI PF01399.22 ESS63803.1 - 0.011 16.0 0.0 0.036 14.3 0.0 1.9 1 0 0 1 1 1 0 PCI domain Fer2_3 PF13085.1 ESS63806.1 - 0.88 9.4 8.9 0.22 11.3 3.8 1.6 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Sds3 PF08598.6 ESS63806.1 - 3.7 7.0 7.9 5.9 6.3 5.4 1.4 1 1 0 1 1 1 0 Sds3-like DUF3552 PF12072.3 ESS63807.1 - 3.3 6.8 11.4 3.9 6.6 7.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) TIP_N PF12457.3 ESS63807.1 - 6.1 6.9 12.2 30 4.7 8.5 1.9 1 1 0 1 1 1 0 Tuftelin interacting protein N terminal EF-hand_8 PF13833.1 ESS63808.1 - 4.2e-08 32.6 1.5 0.00057 19.4 0.1 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 ESS63808.1 - 8.2e-07 29.0 1.1 0.0045 17.0 0.1 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS63808.1 - 8.2e-07 28.3 0.1 0.0014 18.3 0.0 3.1 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 ESS63808.1 - 8.6e-05 21.5 0.4 0.0026 16.9 0.0 3.2 4 0 0 4 4 4 1 EF hand EF-hand_5 PF13202.1 ESS63808.1 - 0.00065 18.9 0.1 0.012 14.9 0.0 2.7 2 0 0 2 2 2 1 EF hand T2SE PF00437.15 ESS63808.1 - 0.029 13.2 0.0 0.03 13.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein SpoIIAA-like PF11964.3 ESS63808.1 - 0.029 14.6 0.3 0.49 10.6 0.0 2.2 2 0 0 2 2 2 0 SpoIIAA-like DUF3349 PF11829.3 ESS63808.1 - 0.048 14.0 0.0 4.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) EF-hand_9 PF14658.1 ESS63808.1 - 0.077 12.9 0.1 0.41 10.6 0.0 2.2 3 0 0 3 3 3 0 EF-hand domain Peptidase_S9 PF00326.16 ESS63809.1 - 1.7e-35 122.2 0.0 3.3e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.16 ESS63809.1 - 2.4e-21 75.7 0.0 4e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_5 PF12695.2 ESS63809.1 - 5.2e-06 26.2 0.0 1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS63809.1 - 0.012 15.5 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 ESS63809.1 - 0.026 13.9 0.3 0.084 12.2 0.2 1.7 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.15 ESS63809.1 - 0.044 13.2 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF3141 PF11339.3 ESS63809.1 - 0.22 9.8 0.1 0.35 9.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Cullin_Nedd8 PF10557.4 ESS63810.1 - 2.5e-19 68.8 0.3 4.8e-19 67.9 0.2 1.4 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.17 ESS63810.1 - 0.0004 19.0 0.0 0.00075 18.1 0.0 1.4 1 0 0 1 1 1 1 Cullin family Sterol_MT_C PF08498.5 ESS63811.1 - 2.7e-11 43.2 0.0 4.8e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 ESS63811.1 - 4.9e-10 39.7 0.0 1.3e-09 38.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS63811.1 - 1.1e-06 28.3 0.0 1.9e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS63811.1 - 0.0035 16.4 0.0 0.0049 16.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 ESS63811.1 - 0.013 15.1 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Aminotran_1_2 PF00155.16 ESS63813.1 - 3.2e-43 148.0 0.0 3.8e-43 147.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 ESS63813.1 - 0.00012 20.4 0.0 0.00016 20.1 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ESS63813.1 - 0.00013 21.1 0.0 0.00016 20.8 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 ESS63813.1 - 0.0014 17.8 0.0 0.002 17.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DUF4186 PF13811.1 ESS63813.1 - 0.0027 17.3 0.1 0.0053 16.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4186) Aminotran_3 PF00202.16 ESS63813.1 - 0.12 11.1 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III zf-CCCH PF00642.19 ESS63816.1 - 2.7e-14 52.4 43.4 0.00074 19.1 0.2 6.0 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHC PF00098.18 ESS63816.1 - 0.0018 18.1 1.1 0.012 15.5 0.7 2.6 1 0 0 1 1 1 1 Zinc knuckle zf-C3H1 PF10650.4 ESS63816.1 - 0.054 12.9 0.6 0.054 12.9 0.4 3.4 4 0 0 4 4 4 0 Putative zinc-finger domain zf-CCCH_2 PF14608.1 ESS63816.1 - 0.16 11.9 0.2 0.16 11.9 0.1 6.1 6 1 0 6 6 6 0 Zinc finger C-x8-C-x5-C-x3-H type zf-UBR PF02207.15 ESS63818.1 - 8.3e-15 54.2 13.1 8.3e-15 54.2 9.1 2.5 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Apc1 PF12859.2 ESS63819.1 - 0.088 13.0 2.7 0.12 12.6 1.8 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 SSP160 PF06933.6 ESS63819.1 - 0.25 9.2 6.0 0.26 9.2 4.1 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.3 ESS63819.1 - 0.7 9.6 6.5 0.74 9.5 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ETRAMP PF09716.5 ESS63819.1 - 0.83 9.6 5.4 1.3 9.0 3.7 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Menin PF05053.8 ESS63819.1 - 1.1 7.2 4.3 1.2 7.2 3.0 1.1 1 0 0 1 1 1 0 Menin Mucin PF01456.12 ESS63819.1 - 1.2 8.8 12.3 1.4 8.6 8.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein NST1 PF13945.1 ESS63819.1 - 1.4 8.9 7.8 1.6 8.7 5.4 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Podoplanin PF05808.6 ESS63819.1 - 2.3 7.7 5.8 2.6 7.5 4.0 1.1 1 0 0 1 1 1 0 Podoplanin Dicty_REP PF05086.7 ESS63819.1 - 7.7 4.1 13.5 8.2 4.0 9.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ribonuc_red_sm PF00268.16 ESS63820.1 - 2.7e-115 384.1 0.8 3.2e-115 383.9 0.6 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF1220 PF06758.8 ESS63820.1 - 0.043 13.6 0.1 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Repeat of unknown function (DUF1220) RNase_H PF00075.19 ESS63821.1 - 2.5e-08 34.3 0.0 4.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 ESS63821.1 - 0.017 14.8 0.0 0.073 12.8 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase-like zf-C2H2_jaz PF12171.3 ESS63821.1 - 0.084 13.0 3.7 4.6 7.4 0.5 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DAN PF03045.10 ESS63821.1 - 0.1 12.0 3.2 0.17 11.3 0.0 2.6 2 0 0 2 2 2 0 DAN domain zf-C2H2 PF00096.21 ESS63821.1 - 3.4 8.2 18.8 1 9.8 1.6 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS63821.1 - 5.8 7.4 16.4 5.9 7.4 1.5 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger ACBP PF00887.14 ESS63822.1 - 1.5e-27 95.0 0.0 2.7e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein DUF4486 PF14858.1 ESS63823.1 - 8.2e-11 40.8 2.2 1.5e-10 39.9 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4486) TPR_12 PF13424.1 ESS63823.1 - 1.4e-05 24.9 15.8 0.42 10.5 0.0 7.4 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63823.1 - 0.011 16.1 3.6 0.43 11.1 0.0 4.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_S9_N PF02897.10 ESS63824.1 - 4.9e-126 420.6 0.0 6.5e-126 420.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.16 ESS63824.1 - 7.4e-66 221.4 0.0 1.1e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family HCaRG PF07258.9 ESS63825.1 - 3e-06 26.8 0.0 5.2e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 HCaRG protein Acyl-CoA_ox_N PF14749.1 ESS63827.1 - 0.23 11.7 1.2 0.33 11.2 0.1 1.8 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Statherin PF03875.8 ESS63827.1 - 9 6.2 5.6 3.4 7.6 0.6 2.5 3 0 0 3 3 3 0 Statherin MT PF12777.2 ESS63828.1 - 8.5e-09 34.6 3.5 8.9e-09 34.5 0.1 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor HipA_C PF07804.7 ESS63828.1 - 0.01 15.9 0.2 3.4 7.8 0.1 3.0 2 0 0 2 2 2 0 HipA-like C-terminal domain AAA PF00004.24 ESS63829.1 - 0.00044 20.4 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.6 ESS63829.1 - 0.00094 19.0 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Torsin DEAD PF00270.24 ESS63830.1 - 9.3e-25 87.0 0.2 1.5e-24 86.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS63830.1 - 1.1e-17 63.6 0.0 1e-16 60.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SecA_DEAD PF07517.9 ESS63830.1 - 0.032 13.5 0.0 0.31 10.2 0.0 2.1 2 1 0 2 2 2 0 SecA DEAD-like domain ResIII PF04851.10 ESS63830.1 - 0.064 13.0 0.3 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit UPF0160 PF03690.8 ESS63831.1 - 2.4e-126 421.4 0.0 2.7e-126 421.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF4237 PF14021.1 ESS63831.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4237) Adaptin_binding PF10199.4 ESS63832.1 - 0.037 14.3 4.6 0.047 13.9 3.2 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 OmpH PF03938.9 ESS63832.1 - 0.29 11.0 9.7 0.39 10.6 6.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Hydrolase PF00702.21 ESS63834.1 - 8.3e-15 55.7 0.0 2.6e-12 47.6 0.0 3.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS63834.1 - 6.6e-12 45.9 0.0 1.5e-10 41.6 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ESS63834.1 - 3.3e-08 32.8 0.3 2.8e-06 26.5 0.0 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.7 ESS63834.1 - 0.043 13.3 0.1 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS63834.1 - 0.14 12.1 0.0 0.83 9.6 0.0 2.2 1 1 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit zf-C3HC4_2 PF13923.1 ESS63835.1 - 4.2e-11 42.6 9.5 4.2e-11 42.6 6.6 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS63835.1 - 1.5e-08 34.1 11.8 1.5e-08 34.1 8.2 4.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS63835.1 - 1.4e-07 31.2 11.3 1.4e-07 31.2 7.8 4.4 4 1 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.1 ESS63835.1 - 1.1e-06 28.2 11.8 1.1e-06 28.2 8.2 4.3 4 1 0 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESS63835.1 - 1.5e-06 27.7 6.8 1.5e-06 27.7 4.7 4.0 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS63835.1 - 2.6e-06 27.2 8.8 2.6e-06 27.2 6.1 3.7 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESS63835.1 - 3e-06 26.8 2.3 9.3e-06 25.2 1.0 2.3 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESS63835.1 - 0.0023 17.6 7.8 0.0023 17.6 5.4 2.7 2 1 1 3 3 3 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 ESS63835.1 - 0.0026 17.8 7.0 0.0026 17.8 4.8 3.9 3 2 0 3 3 3 1 RING-H2 zinc finger U-box PF04564.10 ESS63835.1 - 0.022 14.7 0.0 0.059 13.3 0.0 1.7 1 0 0 1 1 1 0 U-box domain 2Fe-2S_thioredx PF01257.14 ESS63836.1 - 9.5e-50 167.9 0.0 1.2e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin GED PF02212.13 ESS63837.1 - 2.5 8.0 10.1 5.9 6.8 1.7 2.3 2 0 0 2 2 2 0 Dynamin GTPase effector domain RCC1 PF00415.13 ESS63838.1 - 2e-65 216.7 21.3 5.5e-15 55.3 0.3 8.2 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS63838.1 - 2.5e-39 132.0 36.9 1.5e-13 49.9 1.1 7.9 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat BTB_2 PF02214.17 ESS63838.1 - 7.8e-10 38.8 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain CBM_X PF06204.6 ESS63838.1 - 0.026 14.0 0.6 19 4.8 0.0 3.6 3 0 0 3 3 3 0 Putative carbohydrate binding domain DUF4213 PF13938.1 ESS63838.1 - 0.031 14.4 0.4 57 3.9 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4213) Pkinase PF00069.20 ESS63839.1 - 9e-68 228.2 0.0 1.1e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63839.1 - 1.3e-36 126.0 0.0 1.7e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63839.1 - 7.7e-08 31.6 0.0 2.2e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESS63839.1 - 0.0049 16.6 0.1 0.017 14.8 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS63839.1 - 0.16 10.9 2.2 0.16 11.0 0.5 1.7 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family POLO_box PF00659.13 ESS63840.1 - 2.2e-46 155.6 0.4 1.1e-26 92.6 0.0 2.2 2 0 0 2 2 2 2 POLO box duplicated region WD40 PF00400.27 ESS63841.1 - 6.4e-33 111.4 20.8 2.4e-08 33.5 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 ESS63841.1 - 0.00021 19.5 1.7 0.00079 17.6 0.5 2.4 2 1 1 3 3 3 1 Nucleoporin Nup120/160 PQQ_2 PF13360.1 ESS63841.1 - 0.001 18.5 0.1 0.013 14.9 0.0 2.7 2 1 0 2 2 2 1 PQQ-like domain PD40 PF07676.7 ESS63841.1 - 0.0068 16.0 0.0 4.9 6.9 0.0 3.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat EBP PF05241.7 ESS63841.1 - 0.0097 14.9 0.1 0.6 9.0 0.0 2.4 2 0 0 2 2 2 1 Emopamil binding protein Cytochrom_D1 PF02239.11 ESS63841.1 - 0.01 14.1 0.1 0.14 10.4 0.0 2.3 2 2 0 2 2 2 0 Cytochrome D1 heme domain DUF3312 PF11768.3 ESS63841.1 - 0.021 13.0 0.1 0.088 11.0 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3312) Kinesin PF00225.18 ESS63842.1 - 2.4e-73 246.7 0.0 3.6e-73 246.1 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain DUF3508 PF12018.3 ESS63843.1 - 6.6e-12 45.0 0.0 1.3e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3508) TPR_11 PF13414.1 ESS63844.1 - 4.1e-10 39.1 6.4 9.1e-06 25.2 2.2 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS63844.1 - 3.2e-09 36.0 9.6 0.063 13.2 0.2 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESS63844.1 - 2e-07 30.6 0.7 0.56 10.5 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS63844.1 - 3.9e-05 23.0 10.3 0.36 10.5 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS63844.1 - 0.00013 22.2 3.5 0.0042 17.4 0.3 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS63844.1 - 0.0004 20.2 16.1 0.0081 16.0 1.2 4.5 3 2 2 5 5 5 3 Tetratricopeptide repeat Apc3 PF12895.2 ESS63844.1 - 0.0019 18.2 12.7 0.045 13.8 0.1 3.5 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS63844.1 - 0.003 18.0 9.6 0.085 13.5 0.1 5.0 5 1 1 6 6 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63844.1 - 0.0079 16.5 0.7 7 7.3 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat B PF02216.11 ESS63844.1 - 0.0091 15.7 0.1 0.041 13.6 0.1 2.0 2 0 0 2 2 2 1 B domain TPR_16 PF13432.1 ESS63844.1 - 0.081 13.6 5.9 1.3 9.7 0.2 3.4 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS63844.1 - 0.22 11.4 0.0 0.22 11.4 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESS63844.1 - 3.1 7.8 9.8 16 5.5 0.1 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat FUSC PF04632.7 ESS63845.1 - 4.4 5.6 27.1 5.1 5.4 18.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family SASP_gamma PF04259.9 ESS63845.1 - 8.3 6.6 13.7 11 6.2 7.0 2.3 2 0 0 2 2 2 0 Small, acid-soluble spore protein, gamma-type IU_nuc_hydro PF01156.14 ESS63847.1 - 3.9e-06 26.3 0.0 6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Pkinase PF00069.20 ESS63848.1 - 6e-69 232.0 0.0 7.6e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63848.1 - 1.9e-35 122.2 0.0 2.4e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63848.1 - 5e-05 22.3 0.0 8.3e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like LRR_4 PF12799.2 ESS63848.1 - 0.0013 18.3 1.2 0.0013 18.3 0.8 2.3 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESS63848.1 - 0.0017 18.2 3.2 2.8 8.2 0.2 3.9 4 0 0 4 4 4 2 Leucine Rich repeat RIO1 PF01163.17 ESS63848.1 - 0.019 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 RIO1 family LRR_1 PF00560.28 ESS63848.1 - 1.7 8.9 10.2 5.4 7.4 0.2 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat DUF3522 PF12036.3 ESS63850.1 - 2.1e-60 203.6 5.8 2.5e-60 203.4 4.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) ABC2_membrane_6 PF06182.6 ESS63850.1 - 0.28 10.7 6.1 0.3 10.5 3.5 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein TPR_16 PF13432.1 ESS63851.1 - 0.061 14.0 0.1 0.061 14.0 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS63851.1 - 0.48 10.4 6.2 2.2 8.4 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63851.1 - 0.69 10.7 5.9 1.1 10.0 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS63851.1 - 4.4 8.0 9.1 15 6.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RHSP PF07999.6 ESS63853.1 - 7.6e-47 159.8 0.1 1.5e-46 158.9 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS63854.1 - 1.2e-17 63.6 0.0 3.8e-17 62.0 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein PEP_mutase PF13714.1 ESS63854.1 - 0.07 12.3 0.1 3.5 6.7 0.0 2.1 1 1 1 2 2 2 0 Phosphoenolpyruvate phosphomutase zf-RING_2 PF13639.1 ESS63855.1 - 3.6e-11 42.7 5.4 3.6e-11 42.7 3.8 1.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS63855.1 - 1.2e-08 34.8 7.9 1.2e-08 34.8 3.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESS63855.1 - 6.4e-08 32.5 1.2 6.4e-08 32.5 0.9 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 ESS63855.1 - 3.5e-07 29.8 3.6 2.4e-06 27.1 0.3 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.20 ESS63855.1 - 4.4e-07 29.4 3.2 4.4e-07 29.4 2.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS63855.1 - 7.2e-07 28.7 6.3 8.5e-07 28.5 2.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS63855.1 - 1.2e-06 28.2 1.1 1.5e-05 24.7 1.1 2.3 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 ESS63855.1 - 3.8e-06 26.5 2.7 3.8e-06 26.5 1.9 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESS63855.1 - 0.00043 20.0 0.9 0.0008 19.1 0.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 ESS63855.1 - 0.0085 15.6 4.2 0.14 11.7 0.0 3.1 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 CpXC PF14353.1 ESS63855.1 - 0.016 15.1 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 CpXC protein FANCL_C PF11793.3 ESS63855.1 - 0.046 13.6 3.1 1.2 9.0 2.7 2.5 1 1 1 2 2 2 0 FANCL C-terminal domain Prok-RING_1 PF14446.1 ESS63855.1 - 0.19 11.4 0.1 0.19 11.4 0.1 2.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 RINGv PF12906.2 ESS63855.1 - 0.29 11.1 4.0 0.58 10.2 1.8 2.2 2 1 0 2 2 2 0 RING-variant domain zf-RING_4 PF14570.1 ESS63855.1 - 0.42 10.2 2.4 1.1 8.8 1.7 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.7 ESS63855.1 - 0.67 10.1 3.3 19 5.4 2.4 2.4 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Peptidase_M20 PF01546.23 ESS63856.1 - 8.9e-13 48.1 0.0 1.3e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESS63856.1 - 1.3e-09 37.7 0.0 2.8e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.9 ESS63856.1 - 1.1e-07 30.9 0.0 2.2e-06 26.6 0.0 2.5 3 0 0 3 3 3 1 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.12 ESS63856.1 - 0.0039 16.9 0.0 0.0082 15.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 ATP-grasp PF02222.17 ESS63856.1 - 0.049 12.9 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 ATP-grasp domain DUF3522 PF12036.3 ESS63857.1 - 7.3e-59 198.6 7.1 8.6e-59 198.4 5.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) DUF998 PF06197.8 ESS63857.1 - 0.0088 15.3 1.3 0.0088 15.3 0.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF998) DUF331 PF03889.8 ESS63857.1 - 0.11 11.8 0.2 0.21 10.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function MFS_1 PF07690.11 ESS63857.1 - 0.12 11.0 4.6 0.12 11.1 2.5 1.5 1 1 0 1 1 1 0 Major Facilitator Superfamily DUF1304 PF06993.7 ESS63857.1 - 0.16 11.6 3.3 10 5.9 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1304) DUF3488 PF11992.3 ESS63857.1 - 0.47 9.0 4.6 0.65 8.5 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) DUF2231 PF09990.4 ESS63857.1 - 1 9.7 4.6 0.55 10.6 0.8 2.4 2 2 0 2 2 2 0 Predicted membrane protein (DUF2231) TctB PF07331.6 ESS63857.1 - 3.1 7.4 7.9 3.4 7.3 1.1 2.9 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family Ceramidase PF05875.7 ESS63857.1 - 3.1 6.8 13.6 39 3.2 9.4 2.3 1 1 0 1 1 1 0 Ceramidase DUF805 PF05656.9 ESS63857.1 - 3.8 7.3 7.6 21 4.9 5.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF805) LSM PF01423.17 ESS63858.1 - 0.00012 21.4 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 LSM domain Adeno_E4_34 PF04528.8 ESS63858.1 - 1.9 8.0 3.8 2.8 7.5 0.1 2.2 1 1 0 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region Arf PF00025.16 ESS63859.1 - 1.2e-68 229.7 0.1 1.5e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESS63859.1 - 1.5e-11 43.8 0.0 1.9e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 ESS63859.1 - 1e-10 40.8 0.5 2.7e-08 32.9 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 ESS63859.1 - 9.5e-10 38.0 0.0 1.1e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 ESS63859.1 - 1.6e-08 33.9 0.0 2e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESS63859.1 - 1.1e-07 32.3 0.0 1.6e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESS63859.1 - 1.1e-06 28.5 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESS63859.1 - 0.0066 15.8 0.0 0.04 13.3 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESS63859.1 - 0.091 12.0 0.8 0.47 9.7 0.5 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B tRNA-synt_2 PF00152.15 ESS63860.1 - 1e-87 294.0 0.2 1.3e-87 293.7 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESS63860.1 - 7e-11 41.8 0.1 1.3e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESS63860.1 - 9.1e-07 28.3 0.1 0.0044 16.2 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ESS63860.1 - 0.029 13.9 0.1 4.4 6.8 0.0 3.3 3 1 0 4 4 4 0 tRNA synthetase class II core domain (G, H, P, S and T) CP12 PF02672.10 ESS63860.1 - 0.035 14.5 0.6 0.079 13.4 0.4 1.6 1 0 0 1 1 1 0 CP12 domain Cortex-I_coil PF09304.5 ESS63860.1 - 0.23 11.5 4.2 0.12 12.4 0.4 2.1 2 0 0 2 2 2 0 Cortexillin I, coiled coil Seryl_tRNA_N PF02403.17 ESS63860.1 - 0.27 11.2 3.2 0.12 12.3 0.4 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Peptidase_M20 PF01546.23 ESS63861.1 - 3.7e-35 121.1 0.0 4.7e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESS63861.1 - 8.3e-18 64.1 0.0 1.3e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF946 PF06101.6 ESS63861.1 - 0.066 11.1 0.0 0.1 10.5 0.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF946) HECT PF00632.20 ESS63862.1 - 3.7e-92 308.8 0.0 5.6e-92 308.2 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4414 PF14377.1 ESS63862.1 - 2.2e-16 59.7 0.1 3.2e-15 55.9 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4414) DUF773 PF05600.7 ESS63862.1 - 0.5 9.0 0.0 1.1 7.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF773) LRR_4 PF12799.2 ESS63864.1 - 1e-05 25.0 3.3 0.00048 19.6 0.2 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS63864.1 - 0.00018 21.1 1.3 0.0004 20.0 0.9 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.1 ESS63864.1 - 0.0068 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.28 ESS63864.1 - 0.0073 16.1 4.3 0.58 10.4 0.1 4.6 5 1 1 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.1 ESS63864.1 - 0.035 14.1 0.5 54 4.3 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeat LRR_7 PF13504.1 ESS63864.1 - 0.44 10.9 4.2 56 4.6 0.0 4.8 6 0 0 6 6 6 0 Leucine rich repeat Flagellar_rod PF05149.7 ESS63865.1 - 5.5e-10 38.9 23.3 5.5e-10 38.9 16.1 2.2 2 0 0 2 2 2 1 Paraflagellar rod protein LRR_8 PF13855.1 ESS63866.1 - 5.2 6.8 7.6 8.8 6.1 0.3 3.4 3 1 0 3 3 3 0 Leucine rich repeat ABA_GPCR PF12430.3 ESS63867.1 - 2.6e-15 56.0 4.1 2.6e-15 56.0 2.9 1.9 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 ESS63867.1 - 1.8e-12 47.0 0.0 3.4e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3735) NUDIX PF00293.23 ESS63868.1 - 2.5e-09 36.8 0.0 5.2e-09 35.8 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain DEAD PF00270.24 ESS63870.1 - 1.8e-43 147.9 0.0 1.1e-41 142.1 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS63870.1 - 4.1e-22 77.8 0.4 2e-21 75.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS63870.1 - 0.0015 18.4 0.0 0.035 13.9 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 ESS63870.1 - 0.049 13.5 0.0 0.089 12.7 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain UPF0506 PF11703.3 ESS63871.1 - 0.066 13.1 3.4 0.13 12.1 2.3 1.4 1 0 0 1 1 1 0 UPF0506 WD40 PF00400.27 ESS63872.1 - 1.1e-06 28.2 4.6 0.11 12.3 0.4 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat Rav1p_C PF12234.3 ESS63872.1 - 0.00023 19.4 0.0 0.00033 18.9 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal Phage_holin_3 PF05106.7 ESS63872.1 - 0.016 15.2 0.0 0.32 10.9 0.1 2.9 3 0 0 3 3 3 0 Phage holin family (Lysis protein S) Rav1p_C PF12234.3 ESS63873.1 - 1.2e-18 66.6 0.0 2.3e-18 65.7 0.0 1.3 1 1 0 1 1 1 1 RAVE protein 1 C terminal DM4_12 PF07841.8 ESS63876.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 DM4/DM12 family Acyl-CoA_dh_M PF02770.14 ESS63877.1 - 1.7e-12 46.6 0.1 4.2e-12 45.3 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 ESS63877.1 - 8.2e-10 39.2 0.0 1.8e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain DUF663 PF04950.7 ESS63878.1 - 3e-79 266.0 0.0 4.5e-79 265.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 ESS63878.1 - 3.7e-19 68.0 0.1 9.9e-19 66.6 0.0 1.8 2 0 0 2 2 2 1 AARP2CN (NUC121) domain FAT PF02259.18 ESS63879.1 - 8.5e-60 202.5 5.8 1.6e-59 201.7 4.0 1.5 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 ESS63879.1 - 9.9e-58 195.3 0.1 2.3e-57 194.1 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.3 ESS63879.1 - 1.8e-32 112.4 4.0 1.9e-32 112.3 0.2 3.0 3 1 1 4 4 4 1 Domain of unknown function (DUF3385) Rapamycin_bind PF08771.6 ESS63879.1 - 2.1e-27 95.1 0.3 2.1e-27 95.1 0.2 3.0 2 0 0 2 2 2 1 Rapamycin binding domain FATC PF02260.15 ESS63879.1 - 2.7e-17 61.8 0.1 8.9e-17 60.2 0.0 2.0 1 0 0 1 1 1 1 FATC domain UME PF08064.8 ESS63879.1 - 9.8e-06 25.4 1.3 0.15 12.0 0.0 5.0 5 0 0 5 5 5 2 UME (NUC010) domain HEAT_EZ PF13513.1 ESS63879.1 - 0.00035 20.9 8.7 5.8 7.5 0.0 7.2 5 2 2 7 7 7 1 HEAT-like repeat FANCI_S1 PF14675.1 ESS63879.1 - 0.0065 15.8 0.1 0.067 12.5 0.0 2.6 2 0 0 2 2 2 1 FANCI solenoid 1 Ipi1_N PF12333.3 ESS63880.1 - 0.0016 18.3 0.1 0.0053 16.7 0.0 1.9 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Lectin_leg-like PF03388.8 ESS63882.1 - 3.4e-17 62.3 0.0 4.6e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family HECT PF00632.20 ESS63883.1 - 7.1e-57 192.9 0.0 3.8e-56 190.5 0.0 2.2 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESS63883.1 - 3.1e-38 130.6 1.6 1.4e-18 67.1 0.0 4.1 3 1 0 3 3 3 3 SPRY domain Laminin_G_3 PF13385.1 ESS63883.1 - 1e-16 61.5 0.0 1.7e-08 34.8 0.0 3.3 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily UBA PF00627.26 ESS63883.1 - 0.05 13.4 0.2 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 UBA/TS-N domain GSK-3_bind PF05350.7 ESS63883.1 - 0.44 9.9 0.2 0.93 8.8 0.2 1.4 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding CAF1 PF04857.15 ESS63885.1 - 1.9e-43 148.7 2.4 2.7e-43 148.2 1.7 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease AAA PF00004.24 ESS63887.1 - 4.1e-36 124.0 0.0 3.6e-33 114.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS63887.1 - 7e-12 45.6 0.1 1.2e-05 25.4 0.0 3.9 3 2 0 3 3 2 2 AAA domain AAA_16 PF13191.1 ESS63887.1 - 1.9e-11 44.2 4.5 0.00028 20.9 0.0 4.2 3 1 1 4 4 4 2 AAA ATPase domain IstB_IS21 PF01695.12 ESS63887.1 - 9.7e-11 41.3 0.0 6.7e-05 22.3 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_5 PF07728.9 ESS63887.1 - 7.2e-10 38.7 0.0 2.1e-06 27.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESS63887.1 - 1.3e-08 34.8 0.1 5.5e-05 23.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESS63887.1 - 1.6e-08 34.1 0.2 0.004 16.8 0.1 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_17 PF13207.1 ESS63887.1 - 2.4e-08 34.8 0.0 7.9e-06 26.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.7 ESS63887.1 - 8.2e-07 28.3 0.1 0.01 14.9 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin AAA_14 PF13173.1 ESS63887.1 - 2.6e-06 27.3 0.0 9.5e-06 25.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 ESS63887.1 - 6.9e-06 25.3 0.2 0.0024 17.0 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 ESS63887.1 - 1.2e-05 24.4 0.1 6e-05 22.2 0.0 2.2 2 1 1 3 3 2 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 ESS63887.1 - 1.2e-05 25.3 0.0 0.0097 16.0 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.7 ESS63887.1 - 0.00016 21.4 0.0 0.016 14.8 0.0 2.7 2 0 0 2 2 2 1 NACHT domain DUF815 PF05673.8 ESS63887.1 - 0.00017 20.6 0.0 0.019 13.8 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 ESS63887.1 - 0.00028 20.3 0.1 0.018 14.4 0.1 3.0 2 1 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESS63887.1 - 0.00048 19.9 0.0 0.55 9.8 0.0 3.2 2 1 1 3 3 3 1 Archaeal ATPase Sigma54_activ_2 PF14532.1 ESS63887.1 - 0.00056 19.9 0.3 0.41 10.6 0.0 3.5 5 0 0 5 5 3 1 Sigma-54 interaction domain Sigma54_activat PF00158.21 ESS63887.1 - 0.0006 19.3 0.0 0.12 11.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_29 PF13555.1 ESS63887.1 - 0.00092 18.6 0.0 1.5 8.4 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_2 PF07724.9 ESS63887.1 - 0.001 19.0 0.0 0.039 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_30 PF13604.1 ESS63887.1 - 0.001 18.6 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 ESS63887.1 - 0.0016 17.2 0.0 0.0043 15.8 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus ABC_tran PF00005.22 ESS63887.1 - 0.0016 18.7 0.0 0.12 12.6 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.1 ESS63887.1 - 0.002 17.7 0.0 0.022 14.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESS63887.1 - 0.0034 16.9 0.0 0.33 10.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.11 ESS63887.1 - 0.0063 15.3 0.0 2.4 6.8 0.0 2.6 3 0 0 3 3 3 1 AFG1-like ATPase SKI PF01202.17 ESS63887.1 - 0.0076 16.1 0.0 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 Shikimate kinase PhoH PF02562.11 ESS63887.1 - 0.0081 15.4 0.0 0.058 12.6 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_10 PF12846.2 ESS63887.1 - 0.0084 15.5 0.4 7.2 5.9 0.0 3.5 4 1 1 5 5 5 0 AAA-like domain AAA_3 PF07726.6 ESS63887.1 - 0.011 15.4 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESS63887.1 - 0.012 15.9 0.0 0.14 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 ESS63887.1 - 0.015 15.2 0.0 0.094 12.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain DAP3 PF10236.4 ESS63887.1 - 0.026 13.4 0.0 0.97 8.3 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 UPF0079 PF02367.12 ESS63887.1 - 0.038 13.6 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Parvo_NS1 PF01057.12 ESS63887.1 - 0.047 12.5 0.0 0.085 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MCM PF00493.18 ESS63887.1 - 0.079 11.7 0.0 0.18 10.5 0.0 1.5 2 0 0 2 2 1 0 MCM2/3/5 family Rad17 PF03215.10 ESS63887.1 - 0.083 11.5 0.0 1.3 7.6 0.0 2.0 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein ResIII PF04851.10 ESS63887.1 - 0.084 12.6 0.0 6.3 6.5 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TniB PF05621.6 ESS63887.1 - 0.09 11.5 0.0 0.18 10.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein KaiC PF06745.8 ESS63887.1 - 0.18 10.8 0.0 0.54 9.3 0.0 1.7 2 0 0 2 2 2 0 KaiC DUF904 PF06005.7 ESS63888.1 - 0.041 14.1 0.2 0.083 13.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DPPIV_N PF00930.16 ESS63888.1 - 0.12 10.9 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region RabGAP-TBC PF00566.13 ESS63889.1 - 3.9e-25 88.5 0.2 5.8e-25 88.0 0.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1126 PF06565.7 ESS63890.1 - 7e-36 121.3 0.0 3.8e-11 42.2 0.0 3.7 3 0 0 3 3 3 3 Repeat of unknown function (DUF1126) EF-hand_8 PF13833.1 ESS63890.1 - 2.9e-06 26.7 0.7 0.045 13.3 0.1 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS63890.1 - 5.2e-05 22.2 0.1 0.0084 15.3 0.0 3.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 ESS63890.1 - 0.0021 18.1 2.6 0.062 13.4 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS63890.1 - 0.01 15.6 0.3 4.2 7.5 0.0 3.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.1 ESS63890.1 - 0.017 14.4 0.5 1.9 7.9 0.1 3.1 2 0 0 2 2 2 0 EF hand ABC2_membrane PF01061.19 ESS63891.1 - 1.2e-31 109.4 17.0 1.9e-31 108.9 11.8 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESS63891.1 - 1.4e-21 77.2 0.0 2.4e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS63891.1 - 1.9e-07 31.3 0.4 0.00017 21.7 0.0 2.3 1 1 1 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 ESS63891.1 - 0.00014 20.9 14.8 0.00033 19.8 10.3 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_17 PF13207.1 ESS63891.1 - 0.0035 18.1 0.0 0.016 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESS63891.1 - 0.0039 16.3 0.0 0.0066 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS63891.1 - 0.0045 16.9 0.1 0.0097 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.18 ESS63891.1 - 0.008 16.1 0.0 0.02 14.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase SMC_N PF02463.14 ESS63891.1 - 0.013 14.7 0.0 0.13 11.4 0.0 2.3 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESS63891.1 - 0.015 14.8 0.3 0.035 13.6 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 ESS63891.1 - 0.029 14.1 0.0 0.078 12.7 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 ESS63891.1 - 0.049 13.7 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 ESS63891.1 - 0.051 13.1 0.0 0.078 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.7 ESS63891.1 - 0.058 13.0 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.1 ESS63891.1 - 0.084 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 ESS63891.1 - 0.086 11.8 0.0 8.9 5.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain T2SE PF00437.15 ESS63891.1 - 0.1 11.4 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Dynamin_N PF00350.18 ESS63891.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.7 1 1 0 1 1 1 0 Dynamin family FtsK_SpoIIIE PF01580.13 ESS63891.1 - 0.14 11.6 0.2 0.26 10.7 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.12 ESS63891.1 - 0.15 11.8 0.4 0.27 11.0 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 cobW PF02492.14 ESS63891.1 - 0.16 11.3 0.2 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 ESS63891.1 - 0.18 11.5 0.2 1.4 8.6 0.1 2.2 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.1 ESS63891.1 - 0.22 11.1 0.2 0.37 10.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain Ribosomal_S8e PF01201.17 ESS63892.1 - 7.6e-36 123.1 10.1 2.4e-34 118.3 7.0 2.2 1 1 0 1 1 1 1 Ribosomal protein S8e DUF3746 PF12562.3 ESS63892.1 - 0.04 13.7 0.4 0.27 11.1 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3746) DUF4496 PF14908.1 ESS63893.1 - 3.7e-10 39.8 0.0 7.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4496) Bac_DNA_binding PF00216.16 ESS63893.1 - 0.022 14.7 0.1 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial DNA-binding protein TB2_DP1_HVA22 PF03134.14 ESS63894.1 - 1.8e-06 27.5 0.4 2.7e-06 27.0 0.3 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Sec23_trunk PF04811.10 ESS63895.1 - 4.2e-49 167.1 0.0 7e-49 166.3 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 ESS63895.1 - 2.3e-28 97.6 0.2 4e-28 96.8 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESS63895.1 - 5e-19 68.6 1.9 5e-19 68.6 1.3 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 ESS63895.1 - 3.1e-14 52.2 5.8 3.1e-14 52.2 4.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 ESS63895.1 - 0.00047 19.8 0.0 0.0024 17.5 0.0 2.1 2 0 0 2 2 2 1 Gelsolin repeat DUF3322 PF11795.3 ESS63895.1 - 0.14 11.7 0.2 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) TPP_enzyme_N PF02776.13 ESS63896.1 - 0.0041 16.6 1.3 0.0063 16.0 0.4 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Varsurf_PPLC PF03490.8 ESS63900.1 - 8.8e-30 102.1 1.1 1.5e-29 101.3 0.7 1.4 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C PI-PLC-X PF00388.14 ESS63900.1 - 5.8e-07 29.0 0.0 9.2e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain GET2 PF08690.5 ESS63901.1 - 0.23 10.6 2.5 0.34 10.0 1.7 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 WD40 PF00400.27 ESS63903.1 - 0.0013 18.5 0.8 9 6.3 0.0 4.1 3 0 0 3 3 3 3 WD domain, G-beta repeat PPR_3 PF13812.1 ESS63904.1 - 1.9e-19 68.2 3.8 5.6e-05 23.0 0.0 7.3 7 0 0 7 7 7 3 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESS63904.1 - 1.3e-17 63.4 4.8 1.9e-07 30.9 0.0 6.2 7 1 1 8 8 8 3 PPR repeat family PPR PF01535.15 ESS63904.1 - 4.1e-08 32.6 8.2 0.014 15.3 0.1 6.0 7 0 0 7 7 7 2 PPR repeat PPR_1 PF12854.2 ESS63904.1 - 8.7e-06 25.1 0.4 0.078 12.4 0.0 4.6 4 1 0 4 4 4 1 PPR repeat RPN7 PF10602.4 ESS63904.1 - 0.022 14.1 0.3 3.5 6.9 0.0 2.7 2 0 0 2 2 2 0 26S proteasome subunit RPN7 DUF1040 PF06288.8 ESS63904.1 - 0.093 12.9 0.0 0.31 11.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1040) TPR_14 PF13428.1 ESS63904.1 - 0.096 13.3 0.6 22 6.0 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat F_actin_cap_B PF01115.12 ESS63905.1 - 9e-22 77.4 0.0 1.5e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 F-actin capping protein, beta subunit WW PF00397.21 ESS63905.1 - 1.1e-07 31.5 3.3 3.7e-07 29.8 2.3 2.0 1 0 0 1 1 1 1 WW domain M20_dimer PF07687.9 ESS63906.1 - 1.2e-08 34.6 0.0 2.3e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESS63906.1 - 2.8e-06 26.9 0.0 3.1e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Arteri_Gl PF00951.13 ESS63906.1 - 0.018 14.6 1.2 0.029 13.9 0.9 1.3 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein M20_dimer PF07687.9 ESS63907.1 - 8.6e-09 35.1 0.0 1.4e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESS63907.1 - 7.6e-05 22.2 0.0 9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 OST-HTH PF12872.2 ESS63908.1 - 0.013 15.3 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 OST-HTH/LOTUS domain DUF4498 PF14926.1 ESS63909.1 - 0.09 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4498) tRNA_U5-meth_tr PF05958.6 ESS63910.1 - 3.4e-15 55.6 0.0 1.7e-14 53.3 0.0 1.9 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 ESS63910.1 - 1.2e-14 54.1 0.0 2e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS63910.1 - 9.8e-09 34.8 0.0 1.7e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ESS63910.1 - 1.8e-08 34.4 0.0 3.4e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS63910.1 - 1.4e-07 32.0 0.0 2.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS63910.1 - 1.2e-06 28.8 0.0 2.5e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESS63910.1 - 4.6e-05 22.6 0.1 7.6e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.10 ESS63910.1 - 6.2e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.5 ESS63910.1 - 0.00027 20.5 0.0 0.00042 19.9 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.7 ESS63910.1 - 0.00041 20.7 0.0 0.00088 19.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS63910.1 - 0.00097 18.3 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.14 ESS63910.1 - 0.0018 17.8 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 ESS63910.1 - 0.0054 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESS63910.1 - 0.0055 15.7 0.0 0.0094 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.1 ESS63910.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.6 ESS63910.1 - 0.029 13.8 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NodS PF05401.6 ESS63910.1 - 0.03 13.7 0.1 0.055 12.8 0.1 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_23 PF13489.1 ESS63910.1 - 0.057 13.1 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF2370 PF10176.4 ESS63911.1 - 0.048 12.9 2.9 0.085 12.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Pex14_N PF04695.8 ESS63911.1 - 6.2 6.8 10.6 19 5.3 5.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SNAP PF14938.1 ESS63912.1 - 1e-56 192.1 17.5 1.2e-56 191.9 12.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ESS63912.1 - 2.3e-06 27.4 9.5 0.00035 20.4 0.1 3.3 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS63912.1 - 9.1e-05 22.0 0.4 9.1e-05 22.0 0.3 4.1 4 2 0 4 4 4 1 TPR repeat Foie-gras_1 PF11817.3 ESS63912.1 - 0.0003 20.3 5.8 0.19 11.1 0.0 3.2 2 1 0 3 3 3 2 Foie gras liver health family 1 TPR_7 PF13176.1 ESS63912.1 - 0.00041 19.9 5.6 4.1 7.4 0.0 6.6 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS63912.1 - 0.001 19.3 6.5 1.6 9.1 0.0 4.5 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS63912.1 - 0.0013 19.0 8.3 10 6.8 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.2 ESS63912.1 - 0.0018 16.9 2.3 0.0022 16.7 1.6 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_16 PF13432.1 ESS63912.1 - 0.0054 17.3 5.8 3 8.6 0.2 4.2 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS63912.1 - 0.0062 17.0 7.4 5 8.0 0.0 5.2 5 1 0 5 5 5 1 Tetratricopeptide repeat ATP-synt_DE PF00401.15 ESS63912.1 - 0.012 15.4 0.6 0.012 15.4 0.4 3.2 4 0 0 4 4 4 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain TPR_2 PF07719.12 ESS63912.1 - 0.14 12.1 21.6 0.32 11.0 0.0 6.8 8 1 2 10 10 9 0 Tetratricopeptide repeat Sel1 PF08238.7 ESS63912.1 - 0.2 12.3 2.7 17 6.1 0.0 4.3 4 1 1 5 5 5 0 Sel1 repeat Apc3 PF12895.2 ESS63912.1 - 0.23 11.6 9.4 0.66 10.1 0.2 3.6 2 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESS63912.1 - 0.3 10.7 11.8 0.89 9.2 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat NSF PF02071.15 ESS63912.1 - 2 9.3 13.6 23 6.1 0.1 6.0 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_21 PF09976.4 ESS63912.1 - 6.4 6.7 9.3 0.38 10.6 0.9 2.6 2 2 1 3 3 3 0 Tetratricopeptide repeat Peptidase_C50 PF03568.12 ESS63913.1 - 8.4e-36 123.4 0.0 1.6e-30 106.1 0.0 2.1 2 0 0 2 2 2 2 Peptidase family C50 CHAT PF12770.2 ESS63913.1 - 0.00022 20.4 0.0 0.0013 17.9 0.0 2.0 2 0 0 2 2 2 1 CHAT domain DUF3989 PF13150.1 ESS63913.1 - 0.089 12.2 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) Pkinase PF00069.20 ESS63914.1 - 1.5e-54 184.9 0.0 1.7e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS63914.1 - 1.4e-32 112.8 0.0 1.9e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS63914.1 - 0.00089 18.3 0.3 0.003 16.5 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESS63914.1 - 0.0026 16.8 0.0 0.0051 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS63914.1 - 0.069 12.8 0.1 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CHORD PF04968.7 ESS63916.1 - 7.8e-47 157.3 25.1 5.6e-24 84.1 6.2 2.6 2 0 0 2 2 2 2 CHORD AAA PF00004.24 ESS63917.1 - 4.7e-33 114.1 0.0 1.1e-25 90.3 0.0 2.5 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS63917.1 - 4.5e-11 43.0 0.3 0.00012 22.2 0.1 3.7 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.1 ESS63917.1 - 2.5e-09 37.3 9.0 0.00053 20.0 0.2 4.6 3 2 2 5 5 5 2 AAA ATPase domain AAA_17 PF13207.1 ESS63917.1 - 9.1e-09 36.1 0.0 0.00018 22.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ESS63917.1 - 6.9e-07 29.6 0.0 0.003 17.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 ESS63917.1 - 9.5e-07 28.6 4.1 0.002 17.7 0.1 3.8 2 2 0 2 2 2 2 NACHT domain AAA_28 PF13521.1 ESS63917.1 - 1.4e-06 28.4 0.0 0.0037 17.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESS63917.1 - 5.7e-06 26.0 0.1 0.11 12.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESS63917.1 - 6.9e-06 25.9 0.1 0.0018 18.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.12 ESS63917.1 - 1.1e-05 24.8 0.0 0.00069 19.0 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESS63917.1 - 1.3e-05 25.0 0.0 0.0032 17.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ESS63917.1 - 2e-05 24.3 0.1 0.02 14.6 0.1 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 ESS63917.1 - 3.4e-05 23.9 0.0 0.053 13.6 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_19 PF13245.1 ESS63917.1 - 5.9e-05 22.7 1.9 0.0095 15.6 0.2 3.1 3 0 0 3 3 2 1 Part of AAA domain Arch_ATPase PF01637.13 ESS63917.1 - 7.8e-05 22.4 0.0 0.0017 18.0 0.0 2.2 2 0 0 2 2 2 1 Archaeal ATPase AAA_10 PF12846.2 ESS63917.1 - 0.0001 21.8 0.1 0.0092 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain Zeta_toxin PF06414.7 ESS63917.1 - 0.00019 20.6 0.0 0.0062 15.6 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin ABC_tran PF00005.22 ESS63917.1 - 0.00022 21.5 0.0 0.0016 18.7 0.0 2.1 2 0 0 2 2 2 1 ABC transporter T2SE PF00437.15 ESS63917.1 - 0.00024 20.1 0.2 0.02 13.8 0.0 2.5 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_30 PF13604.1 ESS63917.1 - 0.0003 20.4 1.4 0.34 10.4 0.1 3.6 3 1 0 3 3 3 1 AAA domain AAA_2 PF07724.9 ESS63917.1 - 0.00031 20.6 0.0 0.028 14.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_29 PF13555.1 ESS63917.1 - 0.00032 20.1 0.0 0.039 13.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain NTPase_1 PF03266.10 ESS63917.1 - 0.00035 20.3 0.1 0.76 9.4 0.0 2.5 2 0 0 2 2 2 2 NTPase DUF258 PF03193.11 ESS63917.1 - 0.001 18.2 0.0 0.017 14.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRP54 PF00448.17 ESS63917.1 - 0.001 18.5 0.1 0.47 9.8 0.0 2.8 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain TIP49 PF06068.8 ESS63917.1 - 0.0011 17.8 0.1 0.03 13.0 0.0 2.3 2 0 0 2 2 2 1 TIP49 C-terminus AAA_25 PF13481.1 ESS63917.1 - 0.0024 17.2 0.1 0.3 10.4 0.2 3.0 2 1 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.12 ESS63917.1 - 0.0025 17.4 0.0 0.88 9.0 0.0 2.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Miro PF08477.8 ESS63917.1 - 0.0027 18.1 0.0 0.052 14.0 0.1 2.6 2 0 0 2 2 2 1 Miro-like protein ResIII PF04851.10 ESS63917.1 - 0.0037 17.1 0.0 0.39 10.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PRK PF00485.13 ESS63917.1 - 0.0052 16.3 0.0 0.13 11.8 0.0 2.2 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family ArgK PF03308.11 ESS63917.1 - 0.0062 15.3 0.5 1.2 7.8 0.0 2.6 2 1 1 3 3 3 1 ArgK protein Sigma54_activat PF00158.21 ESS63917.1 - 0.0068 15.8 0.1 1.8 7.9 0.0 3.3 4 0 0 4 4 4 1 Sigma-54 interaction domain AAA_24 PF13479.1 ESS63917.1 - 0.0072 15.9 0.0 0.69 9.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 ESS63917.1 - 0.0073 15.9 0.0 0.74 9.4 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Bac_DnaA PF00308.13 ESS63917.1 - 0.013 15.2 0.0 0.35 10.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein RuvB_N PF05496.7 ESS63917.1 - 0.016 14.2 0.1 5.3 6.0 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 ESS63917.1 - 0.02 14.0 0.0 4.1 6.5 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_21 PF13304.1 ESS63917.1 - 0.024 14.6 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 ESS63917.1 - 0.025 14.0 0.1 0.16 11.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AFG1_ATPase PF03969.11 ESS63917.1 - 0.036 12.8 0.0 2.4 6.8 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase cobW PF02492.14 ESS63917.1 - 0.04 13.3 0.1 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.1 ESS63917.1 - 0.06 13.6 0.0 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 ESS63917.1 - 0.083 12.5 0.1 0.71 9.5 0.0 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase PhoH PF02562.11 ESS63917.1 - 0.084 12.0 0.2 2.7 7.1 0.0 3.1 3 1 0 3 3 2 0 PhoH-like protein Myosin_head PF00063.16 ESS63917.1 - 0.095 10.7 0.0 3.2 5.6 0.0 2.1 2 0 0 2 2 2 0 Myosin head (motor domain) PIF1 PF05970.9 ESS63917.1 - 0.14 11.1 0.0 0.89 8.4 0.0 2.0 2 0 0 2 2 2 0 PIF1-like helicase DUF815 PF05673.8 ESS63917.1 - 0.16 10.8 0.0 2.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) KTI12 PF08433.5 ESS63917.1 - 0.17 11.0 0.0 0.82 8.8 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NB-ARC PF00931.17 ESS63917.1 - 0.18 10.6 0.0 11 4.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain KAP_NTPase PF07693.9 ESS63917.1 - 0.18 10.7 0.0 0.68 8.8 0.0 1.8 2 1 1 3 3 2 0 KAP family P-loop domain DUF4455 PF14643.1 ESS63918.1 - 8e-08 31.3 7.5 2.8e-07 29.5 5.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4455) DUF4456 PF14644.1 ESS63919.1 - 6.3e-25 87.6 0.0 6.3e-25 87.6 0.0 4.8 4 2 0 4 4 4 2 Domain of unknown function (DUF4456) HEAT PF02985.17 ESS63920.1 - 0.58 10.3 8.8 0.047 13.7 0.3 4.0 3 1 1 4 4 4 0 HEAT repeat DUF989 PF06181.6 ESS63922.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF989) Med3 PF11593.3 ESS63923.1 - 0.00014 21.2 2.8 0.00021 20.6 1.9 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Rif1_N PF12231.3 ESS63923.1 - 0.16 10.9 0.2 0.85 8.5 0.1 1.9 2 0 0 2 2 2 0 Rap1-interacting factor 1 N terminal Myotub-related PF06602.9 ESS63924.1 - 2.2e-95 319.4 0.0 3.1e-95 318.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE_2 PF02318.11 ESS63924.1 - 0.022 14.6 10.3 0.066 13.1 7.1 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger DSPc PF00782.15 ESS63924.1 - 0.067 12.7 0.0 0.2 11.2 0.0 1.8 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 ESS63924.1 - 0.07 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family FYVE PF01363.16 ESS63924.1 - 5.9 6.8 19.9 12 5.9 12.6 2.5 2 1 0 2 2 2 0 FYVE zinc finger BNR_3 PF13859.1 ESS63926.1 - 9.3e-83 277.8 0.0 1.3e-82 277.3 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain SGS PF05002.10 ESS63927.1 - 1.5e-27 95.1 0.1 2.4e-27 94.5 0.1 1.3 1 0 0 1 1 1 1 SGS domain CS PF04969.11 ESS63927.1 - 3.3e-07 30.7 0.0 5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 CS domain Ribosomal_S17 PF00366.15 ESS63928.1 - 1.4e-25 89.1 1.0 1.4e-25 89.1 0.7 1.8 2 0 0 2 2 2 1 Ribosomal protein S17 Pkr1 PF08636.5 ESS63929.1 - 1.1e-05 25.4 5.8 1.4e-05 25.0 4.1 1.1 1 0 0 1 1 1 1 ER protein Pkr1 2TM PF13239.1 ESS63929.1 - 0.0061 16.6 2.4 0.0085 16.1 1.6 1.2 1 0 0 1 1 1 1 2TM domain DUF4131 PF13567.1 ESS63929.1 - 0.073 12.4 0.1 0.089 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) RNA_ligase PF09414.5 ESS63930.1 - 4.6e-53 179.7 0.1 7.9e-53 179.0 0.0 1.4 2 0 0 2 2 2 1 RNA ligase DNA_ligase_A_M PF01068.16 ESS63930.1 - 0.0022 17.3 0.0 0.0051 16.1 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain FLILHELTA PF10306.4 ESS63930.1 - 0.031 14.3 0.0 0.088 12.8 0.0 1.8 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA DUF2881 PF11087.3 ESS63931.1 - 0.018 14.5 0.4 0.043 13.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2881) PDGLE PF13190.1 ESS63931.1 - 0.021 14.5 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 PDGLE domain Mec-17 PF05301.6 ESS63932.1 - 4.9e-30 103.9 0.1 7.3e-30 103.3 0.1 1.2 1 0 0 1 1 1 1 Touch receptor neuron protein Mec-17 Mito_fiss_reg PF05308.6 ESS63932.1 - 0.025 13.9 4.0 0.039 13.3 2.7 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Acetyltransf_1 PF00583.19 ESS63932.1 - 0.08 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family LMBR1 PF04791.11 ESS63933.1 - 3.4e-21 75.3 11.4 4.4e-21 75.0 7.9 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein ABC2_membrane_3 PF12698.2 ESS63933.1 - 0.39 9.6 19.4 0.0078 15.2 8.7 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein Polysacc_synt PF01943.12 ESS63933.1 - 0.96 8.6 15.4 11 5.1 9.8 2.1 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DUF418 PF04235.7 ESS63933.1 - 4.9 6.8 10.5 2.3 7.8 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF418) ATP-synt_ab PF00006.20 ESS63934.1 - 1.3e-64 217.6 0.1 5.6e-64 215.5 0.0 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESS63934.1 - 6.5e-23 81.3 0.5 1.1e-22 80.6 0.4 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESS63934.1 - 1.1e-11 44.8 0.1 2.7e-11 43.5 0.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 ESS63934.1 - 0.0017 17.7 0.3 0.0072 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 ESS63934.1 - 0.0094 16.1 0.1 0.056 13.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 ESS63934.1 - 0.027 13.5 0.8 0.036 13.1 0.0 1.6 2 0 0 2 2 2 0 KaiC DUF258 PF03193.11 ESS63934.1 - 0.06 12.5 0.1 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF2075 PF09848.4 ESS63934.1 - 0.19 10.6 0.2 3 6.7 0.2 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) WD40 PF00400.27 ESS63935.1 - 0.023 14.5 0.0 0.22 11.4 0.0 2.7 1 1 0 1 1 1 0 WD domain, G-beta repeat zf-CCHH PF10283.4 ESS63936.1 - 0.047 13.5 0.8 0.089 12.6 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger (CX5CX6HX5H) motif PPR_2 PF13041.1 ESS63937.1 - 0.0002 21.2 0.0 0.083 12.8 0.0 3.9 4 0 0 4 4 4 1 PPR repeat family PPR PF01535.15 ESS63937.1 - 0.00051 19.8 1.8 0.013 15.4 0.0 3.9 5 0 0 5 5 5 1 PPR repeat PPR_3 PF13812.1 ESS63937.1 - 0.015 15.5 1.6 27 5.3 0.1 4.6 4 0 0 4 4 4 0 Pentatricopeptide repeat domain CCDC14 PF15254.1 ESS63940.1 - 0.45 8.8 0.0 0.67 8.2 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Cullin PF00888.17 ESS63941.1 - 3.9e-64 217.2 0.0 9.1e-64 216.0 0.0 1.4 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESS63941.1 - 1.1e-18 66.8 0.1 7e-18 64.2 0.0 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain NPL4 PF05021.10 ESS63942.1 - 7.4e-27 94.3 0.0 1.1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 NPL4 family PRP38 PF03371.10 ESS63943.1 - 0.00037 20.1 0.0 0.00064 19.3 0.0 1.4 1 1 0 1 1 1 1 PRP38 family Unstab_antitox PF09720.5 ESS63943.1 - 0.038 13.6 0.0 0.097 12.3 0.0 1.7 1 0 0 1 1 1 0 Putative addiction module component Metallophos PF00149.23 ESS63944.1 - 3.7e-41 140.7 0.4 5.2e-41 140.2 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GIY-YIG PF01541.19 ESS63945.1 - 8.8e-07 29.2 0.0 2.1e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain Sec23_trunk PF04811.10 ESS63946.1 - 1.7e-38 132.3 0.0 2.5e-38 131.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 ESS63946.1 - 8.7e-20 70.0 0.4 4.9e-19 67.6 0.1 2.2 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESS63946.1 - 3.9e-19 68.9 0.2 8.6e-19 67.8 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 ESS63946.1 - 5.7e-13 48.1 9.6 1.4e-12 46.9 6.7 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger vMSA PF00695.14 ESS63946.1 - 0.57 9.3 10.0 0.97 8.5 6.9 1.3 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus EF-hand_7 PF13499.1 ESS63947.1 - 0.0043 17.1 0.0 0.0062 16.6 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair PapD_N PF00345.15 ESS63950.1 - 0.0003 20.5 0.0 0.021 14.5 0.0 2.5 2 0 0 2 2 2 2 Pili and flagellar-assembly chaperone, PapD N-terminal domain Motile_Sperm PF00635.21 ESS63950.1 - 0.012 15.2 0.0 0.32 10.6 0.0 2.4 2 0 0 2 2 2 0 MSP (Major sperm protein) domain Glyco_trans_1_2 PF13524.1 ESS63952.1 - 0.015 15.5 1.0 0.038 14.2 0.7 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 UCH PF00443.24 ESS63960.1 - 3.9e-43 147.5 0.0 8e-43 146.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS63960.1 - 2.3e-19 69.9 1.6 8.4e-18 64.8 1.1 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Baculo_ME53 PF06061.6 ESS63960.1 - 0.088 11.7 0.2 0.19 10.6 0.1 1.5 1 0 0 1 1 1 0 Baculoviridae ME53 TMEM173 PF15009.1 ESS63962.1 - 0.042 12.6 0.3 0.041 12.6 0.2 1.0 1 0 0 1 1 1 0 Transmembrane protein 173 GP4 PF03010.9 ESS63962.1 - 0.5 9.9 7.7 0.6 9.7 5.3 1.1 1 0 0 1 1 1 0 GP4 Transaldolase PF00923.14 ESS63963.1 - 1.2e-93 313.4 0.0 1.4e-93 313.2 0.0 1.0 1 0 0 1 1 1 1 Transaldolase DUF740 PF05340.7 ESS63963.1 - 0.21 9.9 0.0 0.29 9.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) SH3BGR PF04908.10 ESS63964.1 - 2.8e-06 27.2 0.0 3.6e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.19 ESS63964.1 - 0.023 14.6 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin DUF1162 PF06650.7 ESS63965.1 - 8.2e-11 41.6 0.0 1.2e-06 27.9 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1162) Pex24p PF06398.6 ESS63965.1 - 0.00042 19.2 5.9 0.00057 18.7 0.0 2.5 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin ATG_C PF09333.6 ESS63965.1 - 0.074 13.2 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 ATG C terminal domain Chorein_N PF12624.2 ESS63968.1 - 6.8e-20 70.7 0.1 1.7e-09 37.2 0.0 2.6 2 0 0 2 2 2 2 N-terminal region of Chorein, a TM vesicle-mediated sorter HrpA_pilin PF09589.5 ESS63968.1 - 0.033 14.6 1.2 0.098 13.0 0.0 2.3 2 0 0 2 2 2 0 HrpA pilus formation protein Mem_trans PF03547.13 ESS63969.1 - 2.6e-06 26.0 7.7 9.4e-05 20.8 1.5 2.2 2 0 0 2 2 2 2 Membrane transport protein Mem_trans PF03547.13 ESS63970.1 - 9.5e-05 20.8 7.2 0.1 10.8 4.2 2.1 2 0 0 2 2 2 2 Membrane transport protein Methyltransf_18 PF12847.2 ESS63971.1 - 0.039 14.5 0.0 0.07 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_7 PF13499.1 ESS63972.1 - 4.5e-07 29.9 0.0 1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS63972.1 - 3.5e-06 26.5 0.0 0.00011 21.6 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS63972.1 - 1.5e-05 23.9 0.0 0.0089 15.2 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 ESS63972.1 - 0.00069 19.2 0.2 0.97 9.4 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 ESS63972.1 - 0.017 14.4 0.2 0.1 11.9 0.0 2.4 3 0 0 3 3 3 0 EF hand Fe-S_biosyn PF01521.15 ESS63973.1 - 1.1e-07 31.7 0.0 3.5e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Iron-sulphur cluster biosynthesis Dicty_REP PF05086.7 ESS63973.1 - 0.12 10.1 2.3 0.15 9.7 1.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2823 PF11034.3 ESS63973.1 - 3.8 7.7 5.9 4.2 7.5 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2823) DUF1738 PF08401.6 ESS63974.1 - 4.3e-09 36.1 0.0 0.00015 21.4 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF1738) Exo_endo_phos PF03372.18 ESS63975.1 - 2.9e-25 89.6 0.1 3.4e-25 89.4 0.0 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESS63975.1 - 0.00015 21.3 0.0 0.00086 18.9 0.0 2.2 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase DGF-1_5 PF11038.3 ESS63976.1 - 4.5e-78 262.2 2.7 5.8e-78 261.8 0.0 2.7 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS63976.1 - 0.036 13.9 2.7 0.049 13.5 0.4 2.4 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Nop52 PF05997.7 ESS63977.1 - 3.4e-35 121.4 2.2 3.4e-29 101.8 1.6 3.5 3 0 0 3 3 3 3 Nucleolar protein,Nop52 DUF2413 PF10310.4 ESS63977.1 - 0.034 12.9 0.1 0.034 12.9 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2413) PIN PF01850.16 ESS63977.1 - 0.74 10.1 4.9 2.2 8.6 0.2 3.0 3 0 0 3 3 3 0 PIN domain CDC45 PF02724.9 ESS63977.1 - 2.7 5.9 14.1 0.095 10.7 0.3 2.4 2 0 0 2 2 2 0 CDC45-like protein Ycf1 PF05758.7 ESS63980.1 - 0.56 7.8 1.6 0.74 7.4 1.1 1.1 1 0 0 1 1 1 0 Ycf1 TRAP_alpha PF03896.11 ESS63980.1 - 0.85 8.5 4.7 1.3 7.9 3.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Merozoite_SPAM PF07133.6 ESS63980.1 - 6 6.7 22.7 10 6.0 15.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) EF-hand_1 PF00036.27 ESS63981.1 - 9.5e-07 27.6 0.5 0.0027 16.9 0.0 3.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 ESS63981.1 - 1.9e-06 27.2 3.9 0.014 15.1 0.0 3.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 ESS63981.1 - 0.00012 21.6 1.1 0.16 11.5 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 ESS63981.1 - 0.00012 22.0 2.2 0.033 14.3 1.5 2.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 ESS63981.1 - 0.017 14.4 0.0 0.017 14.4 0.0 3.3 3 1 0 3 3 3 0 EF hand Phage_integrase PF00589.17 ESS63982.1 - 0.036 13.7 0.3 0.064 12.9 0.2 1.7 1 1 0 1 1 1 0 Phage integrase family RNase_H PF00075.19 ESS63983.1 - 1.4e-12 48.0 0.0 2.1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 RNase H EBP50_C-term PF09007.6 ESS63983.1 - 0.094 12.5 0.9 0.2 11.5 0.1 1.9 2 0 0 2 2 2 0 EBP50, C-terminal zf-C2H2_jaz PF12171.3 ESS63983.1 - 0.24 11.5 3.7 7.5 6.8 0.5 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 ESS63983.1 - 0.97 9.6 7.3 3.2 7.9 5.0 1.8 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Acyl-CoA_dh_1 PF00441.19 ESS63984.1 - 9.2e-41 139.4 1.5 1.5e-40 138.7 1.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESS63984.1 - 1.2e-27 96.7 0.0 4.9e-27 94.7 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESS63984.1 - 5.7e-19 67.3 0.2 1.3e-18 66.2 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESS63984.1 - 1.8e-18 67.0 0.1 2.9e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.1 ESS63984.1 - 0.0019 18.4 0.0 0.0035 17.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal XRN_N PF03159.13 ESS63985.1 - 1.3e-18 67.2 0.0 2.9e-18 66.1 0.0 1.5 1 1 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XPG_N PF00752.12 ESS63985.1 - 0.014 15.5 0.0 0.058 13.6 0.0 2.0 2 1 0 2 2 2 0 XPG N-terminal domain Rhodopsin_N PF10413.4 ESS63985.1 - 0.15 11.7 0.3 0.31 10.7 0.2 1.5 1 0 0 1 1 1 0 Amino terminal of the G-protein receptor rhodopsin ARD PF03079.9 ESS63986.1 - 2.3e-15 56.9 0.0 3.6e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 ARD/ARD' family DUF953 PF06110.6 ESS63986.1 - 8.3e-14 51.0 0.0 1.3e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Cupin_2 PF07883.6 ESS63986.1 - 6.2e-06 25.6 0.0 8.6e-05 21.9 0.0 2.5 2 0 0 2 2 2 1 Cupin domain Cupin_6 PF12852.2 ESS63986.1 - 0.0047 16.5 0.0 0.012 15.2 0.0 1.7 1 1 1 2 2 2 1 Cupin AraC_binding PF02311.14 ESS63986.1 - 0.023 14.3 0.0 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 AraC-like ligand binding domain Thioredoxin_8 PF13905.1 ESS63986.1 - 0.023 14.7 0.0 0.11 12.6 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin PF00085.15 ESS63986.1 - 0.078 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin GIT_SHD PF08518.6 ESS63988.1 - 0.027 13.8 0.4 0.079 12.3 0.3 1.8 1 0 0 1 1 1 0 Spa2 homology domain (SHD) of GIT TPD52 PF04201.10 ESS63990.1 - 3.6 7.2 6.1 6.5 6.4 4.2 1.4 1 1 0 1 1 1 0 Tumour protein D52 family TatD_DNase PF01026.16 ESS63991.1 - 1.7e-10 40.5 0.0 3.1e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 TatD related DNase Sec6 PF06046.8 ESS63992.1 - 4.4e-09 34.9 0.2 6e-09 34.5 0.2 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 DUF577 PF04510.7 ESS63992.1 - 0.03 14.0 1.4 0.042 13.5 1.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF577) NLE PF08154.7 ESS63992.1 - 0.071 13.1 0.1 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 NLE (NUC135) domain RAG2 PF03089.9 ESS63992.1 - 0.11 11.2 0.1 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Recombination activating protein 2 Cep57_CLD PF14073.1 ESS63995.1 - 4.9 6.9 11.8 0.091 12.5 2.6 2.0 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Terminase_5 PF06056.7 ESS63996.1 - 0.058 12.9 0.2 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) AAA PF00004.24 ESS63997.1 - 2.9e-87 289.5 0.0 9.2e-48 161.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS63997.1 - 1.3e-15 57.0 0.0 1.6e-07 30.6 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESS63997.1 - 1.3e-13 51.3 0.5 2.6e-05 24.3 0.0 4.5 3 2 2 5 5 4 2 AAA ATPase domain AAA_5 PF07728.9 ESS63997.1 - 7.7e-11 41.8 0.1 0.00029 20.5 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESS63997.1 - 2.6e-10 40.4 0.0 2.8e-05 24.1 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESS63997.1 - 4.7e-10 39.7 0.2 0.0037 17.4 0.0 4.3 2 2 2 4 4 4 2 AAA domain AAA_14 PF13173.1 ESS63997.1 - 5.4e-10 39.2 0.0 0.0012 18.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ESS63997.1 - 8.8e-10 38.0 0.0 1.9e-05 23.8 0.0 2.8 2 0 0 2 2 2 2 Zeta toxin AAA_33 PF13671.1 ESS63997.1 - 5.2e-09 36.1 0.4 0.0021 17.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_17 PF13207.1 ESS63997.1 - 3.1e-08 34.4 0.0 0.0012 19.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESS63997.1 - 1.1e-07 31.5 0.7 0.017 14.8 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain RNA_helicase PF00910.17 ESS63997.1 - 2.4e-07 30.8 0.0 0.027 14.6 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.1 ESS63997.1 - 4.4e-06 26.7 0.0 0.093 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 ESS63997.1 - 4.9e-06 26.0 0.0 0.029 13.7 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.7 ESS63997.1 - 6.7e-06 25.8 0.3 0.13 11.9 0.0 3.6 4 0 0 4 4 3 2 NACHT domain Mg_chelatase PF01078.16 ESS63997.1 - 1.1e-05 24.7 0.2 0.044 12.9 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESS63997.1 - 1.4e-05 24.0 0.0 0.11 11.2 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus ABC_tran PF00005.22 ESS63997.1 - 2.1e-05 24.8 0.0 0.52 10.6 0.0 2.9 2 1 0 2 2 2 2 ABC transporter AAA_18 PF13238.1 ESS63997.1 - 2.9e-05 24.3 0.0 0.12 12.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 ESS63997.1 - 3e-05 23.6 0.0 0.18 11.2 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.1 ESS63997.1 - 6.3e-05 22.6 0.4 0.12 11.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.6 ESS63997.1 - 8.7e-05 22.1 0.0 0.36 10.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESS63997.1 - 9.4e-05 22.2 0.0 0.00063 19.5 0.0 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Sigma54_activ_2 PF14532.1 ESS63997.1 - 0.00019 21.4 0.0 0.03 14.3 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.1 ESS63997.1 - 0.00021 20.7 3.4 1.1 8.5 0.0 3.9 2 2 1 4 4 4 2 AAA domain AAA_24 PF13479.1 ESS63997.1 - 0.00032 20.3 0.3 0.094 12.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 ESS63997.1 - 0.00045 20.0 0.0 1.1 8.9 0.0 3.1 2 2 1 3 3 3 1 Archaeal ATPase NB-ARC PF00931.17 ESS63997.1 - 0.00049 19.0 0.0 0.24 10.2 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Sigma54_activat PF00158.21 ESS63997.1 - 0.0005 19.5 0.0 0.082 12.3 0.0 2.9 3 0 0 3 3 2 1 Sigma-54 interaction domain Rad17 PF03215.10 ESS63997.1 - 0.00086 18.0 0.2 0.28 9.7 0.0 2.6 2 1 1 3 3 3 1 Rad17 cell cycle checkpoint protein Parvo_NS1 PF01057.12 ESS63997.1 - 0.0015 17.4 0.1 0.37 9.6 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 UPF0079 PF02367.12 ESS63997.1 - 0.0019 17.8 0.0 2.5 7.7 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 NTPase_1 PF03266.10 ESS63997.1 - 0.0046 16.6 0.5 1.1 8.8 0.0 2.9 3 0 0 3 3 3 1 NTPase Bac_DnaA PF00308.13 ESS63997.1 - 0.0056 16.3 0.4 2 7.9 0.1 2.7 2 1 0 2 2 2 1 Bacterial dnaA protein DUF815 PF05673.8 ESS63997.1 - 0.0079 15.1 0.0 3.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.20 ESS63997.1 - 0.026 14.0 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain SKI PF01202.17 ESS63997.1 - 0.027 14.3 0.0 0.41 10.4 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase KaiC PF06745.8 ESS63997.1 - 0.032 13.3 0.1 2.6 7.0 0.0 2.7 2 1 0 2 2 2 0 KaiC CPT PF07931.7 ESS63997.1 - 0.034 13.7 0.1 6 6.4 0.0 2.8 3 0 0 3 3 2 0 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.1 ESS63997.1 - 0.049 13.1 0.1 12 5.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain PhoH PF02562.11 ESS63997.1 - 0.083 12.1 0.4 4.3 6.5 0.0 2.8 3 0 0 3 3 3 0 PhoH-like protein AAA_23 PF13476.1 ESS63997.1 - 0.11 12.8 0.0 23 5.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.4 ESS63997.1 - 0.11 11.3 0.0 6 5.6 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.4 ESS63997.1 - 0.19 11.2 0.1 18 4.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Aminotran_5 PF00266.14 ESS63999.1 - 4.3e-86 288.9 0.0 5.6e-86 288.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESS63999.1 - 3.8e-09 36.1 0.0 5.9e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 ESS63999.1 - 0.00022 20.3 0.0 0.00035 19.7 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.14 ESS63999.1 - 0.0022 16.4 0.0 0.0035 15.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain AAA PF00004.24 ESS64000.1 - 4.7e-36 123.9 0.1 6.4e-30 104.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS64000.1 - 1.9e-15 57.1 0.2 2.5e-07 30.8 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESS64000.1 - 2.3e-11 44.0 0.1 2.2e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.1 ESS64000.1 - 4e-10 39.2 0.2 7.1e-05 22.4 0.1 2.6 2 0 0 2 2 2 2 Part of AAA domain AAA_17 PF13207.1 ESS64000.1 - 7.5e-10 39.6 0.6 0.00041 21.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESS64000.1 - 2.6e-09 36.9 0.1 0.00069 19.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS64000.1 - 5.7e-08 32.1 0.0 0.0019 17.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 ESS64000.1 - 7.8e-08 32.6 0.1 0.0021 18.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 ESS64000.1 - 1e-07 31.9 0.0 0.011 15.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 ESS64000.1 - 1.2e-07 31.3 0.0 0.0013 18.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein RuvB_N PF05496.7 ESS64000.1 - 6.6e-07 28.6 0.0 0.012 14.6 0.0 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DUF2075 PF09848.4 ESS64000.1 - 7.7e-07 28.3 0.0 0.0067 15.4 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 ESS64000.1 - 1.4e-06 28.2 0.0 0.03 14.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 ESS64000.1 - 2e-06 26.8 0.0 0.002 16.8 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus NACHT PF05729.7 ESS64000.1 - 2.3e-06 27.3 0.0 0.077 12.6 0.0 2.7 2 0 0 2 2 2 2 NACHT domain Sigma54_activat PF00158.21 ESS64000.1 - 2.3e-06 27.1 0.0 0.021 14.2 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_2 PF07724.9 ESS64000.1 - 5.7e-06 26.3 0.0 0.00053 19.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) NB-ARC PF00931.17 ESS64000.1 - 5.8e-06 25.3 0.0 0.0031 16.3 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain KTI12 PF08433.5 ESS64000.1 - 6e-06 25.6 0.0 0.047 12.9 0.0 2.3 2 0 0 2 2 2 2 Chromatin associated protein KTI12 RNA_helicase PF00910.17 ESS64000.1 - 9.7e-06 25.7 0.0 0.22 11.6 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.22 ESS64000.1 - 1.4e-05 25.3 0.1 0.13 12.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter UPF0079 PF02367.12 ESS64000.1 - 1.6e-05 24.4 0.0 0.083 12.5 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 AAA_24 PF13479.1 ESS64000.1 - 2.4e-05 24.0 0.0 0.0038 16.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESS64000.1 - 6.8e-05 22.3 0.2 0.14 11.5 0.0 3.3 2 1 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESS64000.1 - 7e-05 22.6 0.0 0.0056 16.4 0.0 2.5 2 0 0 2 2 2 1 Archaeal ATPase AAA_11 PF13086.1 ESS64000.1 - 0.00011 21.8 0.0 0.12 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ESS64000.1 - 0.00017 20.7 0.0 0.34 9.9 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin cobW PF02492.14 ESS64000.1 - 0.00073 19.0 0.2 0.15 11.5 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain T2SE PF00437.15 ESS64000.1 - 0.00099 18.0 0.0 0.18 10.6 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_28 PF13521.1 ESS64000.1 - 0.0012 18.8 0.0 0.49 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 ESS64000.1 - 0.0013 18.6 0.0 1.4 8.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.11 ESS64000.1 - 0.0013 18.0 0.0 0.72 9.0 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein Parvo_NS1 PF01057.12 ESS64000.1 - 0.0018 17.2 0.0 0.12 11.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 KaiC PF06745.8 ESS64000.1 - 0.0021 17.2 0.0 0.38 9.8 0.0 2.6 2 0 0 2 2 2 1 KaiC Zot PF05707.7 ESS64000.1 - 0.0054 16.2 0.0 3.1 7.2 0.0 2.7 3 0 0 3 3 2 1 Zonular occludens toxin (Zot) AAA_10 PF12846.2 ESS64000.1 - 0.0055 16.1 0.0 0.25 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA-like domain AAA_30 PF13604.1 ESS64000.1 - 0.006 16.1 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 ESS64000.1 - 0.011 15.7 0.0 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.6 ESS64000.1 - 0.014 14.9 0.0 0.7 9.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESS64000.1 - 0.015 15.0 0.1 7.7 6.1 0.0 2.6 2 0 0 2 2 2 0 NTPase RecA PF00154.16 ESS64000.1 - 0.029 13.4 0.1 3.3 6.6 0.0 2.2 2 0 0 2 2 2 0 recA bacterial DNA recombination protein ATP-synt_ab PF00006.20 ESS64000.1 - 0.037 13.5 0.0 0.76 9.2 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain SRPRB PF09439.5 ESS64000.1 - 0.056 12.6 0.0 3.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MobB PF03205.9 ESS64000.1 - 0.058 13.0 0.1 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CPT PF07931.7 ESS64000.1 - 0.058 13.0 0.0 15 5.1 0.0 2.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Viral_helicase1 PF01443.13 ESS64000.1 - 0.06 12.8 0.0 5.6 6.4 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.13 ESS64000.1 - 0.12 11.7 0.0 7.6 5.9 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_13 PF13166.1 ESS64000.1 - 0.21 10.0 0.0 0.34 9.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain EBP PF05241.7 ESS64001.1 - 5.7e-32 110.3 0.7 5.7e-32 110.3 0.5 1.8 2 0 0 2 2 2 1 Emopamil binding protein DUF2613 PF11021.3 ESS64002.1 - 0.031 13.9 0.4 0.13 11.9 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) WGG PF10273.4 ESS64003.1 - 4.2e-05 23.5 2.8 0.00023 21.1 1.9 1.9 1 1 0 1 1 1 1 Pre-rRNA-processing protein TSR2 TPR_11 PF13414.1 ESS64004.1 - 7.6e-32 108.7 34.2 6e-11 41.8 1.4 7.5 4 2 4 8 8 8 7 TPR repeat TPR_12 PF13424.1 ESS64004.1 - 1.9e-28 98.1 37.5 4.4e-08 32.9 0.5 8.7 5 3 4 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESS64004.1 - 1.9e-24 85.7 10.5 4e-05 24.1 0.0 7.2 5 1 3 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.23 ESS64004.1 - 7.8e-23 79.0 34.8 0.00023 20.6 0.4 10.7 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_2 PF07719.12 ESS64004.1 - 1.8e-21 74.2 38.6 0.011 15.5 0.0 12.2 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_8 PF13181.1 ESS64004.1 - 2.6e-18 64.3 23.9 0.0044 16.7 0.3 10.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS64004.1 - 3.6e-18 64.4 6.3 0.0062 17.0 0.0 10.1 3 3 5 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESS64004.1 - 2.5e-16 59.7 16.8 0.0017 18.6 0.1 7.5 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.1 ESS64004.1 - 8.4e-15 54.1 21.1 0.0052 17.1 0.0 10.9 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS64004.1 - 4.2e-13 48.0 18.0 0.23 11.3 0.0 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat Apc3 PF12895.2 ESS64004.1 - 1.5e-10 41.0 27.6 0.00058 19.9 0.3 7.2 6 1 2 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESS64004.1 - 2.3e-06 27.3 23.9 0.11 12.7 0.6 9.0 11 0 0 11 11 9 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESS64004.1 - 2.4e-06 27.2 25.8 0.53 10.2 0.0 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_4 PF07721.9 ESS64004.1 - 0.0018 18.5 1.5 39 5.0 0.1 5.5 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR PF01535.15 ESS64004.1 - 0.0047 16.8 10.5 5 7.3 0.1 6.5 7 0 0 7 7 6 2 PPR repeat TPR_21 PF09976.4 ESS64004.1 - 0.07 13.0 0.1 0.07 13.0 0.1 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat CbiG_mid PF11761.3 ESS64004.1 - 0.098 12.8 0.0 0.32 11.2 0.0 1.8 1 0 0 1 1 1 0 Cobalamin biosynthesis central region MFS_1 PF07690.11 ESS64006.1 - 2.7e-18 65.8 22.7 7.6e-18 64.3 15.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Spore_YhcN_YlaJ PF09580.5 ESS64006.1 - 0.18 11.9 0.2 0.24 11.5 0.1 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) JmjC PF02373.17 ESS64007.1 - 1.4e-12 47.9 0.1 5.4e-11 42.7 0.1 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 ESS64007.1 - 0.00056 19.4 0.0 0.003 17.0 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.6 ESS64007.1 - 0.035 13.6 0.0 0.11 12.0 0.0 1.8 1 0 0 1 1 1 0 Cupin domain RAI16-like PF10257.4 ESS64008.1 - 8.6e-11 41.3 0.0 5.5e-10 38.6 0.0 2.2 2 1 0 2 2 2 1 Retinoic acid induced 16-like protein Sushi_2 PF09014.5 ESS64008.1 - 0.099 12.4 0.0 4.4 7.1 0.0 3.0 3 0 0 3 3 3 0 Beta-2-glycoprotein-1 fifth domain SMC_hinge PF06470.8 ESS64009.1 - 0.0021 18.0 0.0 0.012 15.6 0.0 1.9 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain eIF-1a PF01176.14 ESS64009.1 - 0.0065 15.8 0.3 0.036 13.4 0.1 2.0 2 0 0 2 2 2 1 Translation initiation factor 1A / IF-1 SpoIIE PF07228.7 ESS64010.1 - 7.3e-06 25.8 0.0 9.7e-05 22.1 0.0 2.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESS64010.1 - 4.5e-05 22.9 0.0 7.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C zf-rbx1 PF12678.2 ESS64011.1 - 8.1e-11 41.8 8.5 1.9e-10 40.6 5.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESS64011.1 - 4.9e-10 39.0 10.7 1.3e-09 37.7 7.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESS64011.1 - 4.8e-06 26.1 12.2 1.2e-05 24.8 8.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS64011.1 - 7.1e-06 25.5 8.1 2.2e-05 24.0 5.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS64011.1 - 1.6e-05 24.5 9.4 4.6e-05 23.0 6.5 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESS64011.1 - 1.9e-05 24.6 11.4 1.9e-05 24.6 7.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS64011.1 - 1.9e-05 24.3 8.5 9.3e-05 22.1 5.3 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 ESS64011.1 - 0.32 10.7 9.5 0.92 9.2 6.6 1.9 1 0 0 1 1 1 0 PHD-finger zf-RING_UBOX PF13445.1 ESS64011.1 - 0.61 9.8 7.2 1.9 8.2 5.0 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 ESS64011.1 - 1.3 8.6 8.4 3.9 7.1 5.8 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FAM176 PF14851.1 ESS64012.1 - 0.41 10.3 4.6 0.97 9.1 3.2 1.7 1 0 0 1 1 1 0 FAM176 family IF-2B PF01008.12 ESS64013.1 - 6.2e-32 110.7 0.0 1.1e-31 109.8 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family LIF_OSM PF01291.12 ESS64015.1 - 0.13 12.2 2.7 0.7 9.7 0.2 2.7 2 0 0 2 2 2 0 LIF / OSM family Rgp1 PF08737.5 ESS64015.1 - 1.1 8.2 9.3 1.2 8.1 5.0 2.1 1 1 0 1 1 1 0 Rgp1 Baculo_PEP_C PF04513.7 ESS64015.1 - 1.3 8.8 10.6 0.26 11.0 0.4 3.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ESS64015.1 - 1.4 8.8 10.3 0.87 9.4 0.2 4.3 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Imm2 PF14426.1 ESS64015.1 - 2.1 8.3 4.9 4.4 7.3 0.5 2.8 2 0 0 2 2 2 0 Immunity protein Imm2 Fucose_iso_N2 PF07882.7 ESS64015.1 - 8.8 5.9 10.2 11 5.6 2.2 2.6 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain NNMT_PNMT_TEMT PF01234.12 ESS64016.1 - 0.093 11.6 0.0 3.5 6.5 0.0 2.3 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Prominin PF05478.6 ESS64016.1 - 0.57 7.6 1.5 0.82 7.1 1.0 1.1 1 0 0 1 1 1 0 Prominin EMP70 PF02990.11 ESS64018.1 - 1.6e-134 449.2 19.1 2.2e-134 448.8 13.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Tom7 PF08038.7 ESS64018.1 - 2.1 7.8 6.6 0.13 11.7 0.4 2.2 2 0 0 2 2 2 0 TOM7 family Isy1 PF06246.7 ESS64019.1 - 1.9e-13 50.4 4.4 1.8e-12 47.2 3.1 2.3 1 1 0 1 1 1 1 Isy1-like splicing family DOT1 PF08123.8 ESS64020.1 - 4.1e-24 85.0 0.0 6.3e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.1 ESS64020.1 - 2e-06 27.4 0.0 4.2e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS64020.1 - 2.3e-06 28.1 0.0 3.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS64020.1 - 0.00019 21.4 0.0 0.00036 20.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS64020.1 - 0.00034 20.9 0.0 0.00092 19.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS64020.1 - 0.00039 20.8 0.0 0.00098 19.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESS64020.1 - 0.0025 17.4 0.0 0.0043 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESS64020.1 - 0.0028 16.7 0.0 0.0043 16.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UPF0020 PF01170.13 ESS64020.1 - 0.025 14.1 0.0 0.04 13.4 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.7 ESS64020.1 - 0.035 14.5 0.0 0.071 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 ESS64020.1 - 0.035 13.4 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.8 ESS64020.1 - 0.042 13.9 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_4 PF02390.12 ESS64020.1 - 0.043 12.8 0.0 0.072 12.1 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase MTS PF05175.9 ESS64020.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Peptidase_M20 PF01546.23 ESS64021.1 - 2.1e-36 125.1 0.0 2.7e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESS64021.1 - 2e-21 75.8 0.0 3.3e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.9 ESS64021.1 - 0.012 14.4 0.0 0.22 10.2 0.0 2.2 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase Adaptin_N PF01602.15 ESS64024.1 - 8.5e-72 242.1 3.3 9.8e-72 241.9 2.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.17 ESS64024.1 - 0.031 14.3 0.1 64 4.0 0.0 4.4 3 1 1 4 4 4 0 HEAT repeat Alpha_adaptinC2 PF02883.15 ESS64025.1 - 0.045 14.0 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 Adaptin C-terminal domain Cytochrom_C1 PF02167.10 ESS64026.1 - 9.7e-63 211.7 0.0 1.2e-62 211.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family Peptidase_M16_C PF05193.16 ESS64028.1 - 1.4e-25 90.0 0.0 2.6e-14 53.3 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain M16C_assoc PF08367.6 ESS64028.1 - 3e-24 85.2 0.0 6.9e-24 84.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16 PF00675.15 ESS64028.1 - 4e-10 39.6 0.0 2.9e-09 36.8 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) EF-hand_8 PF13833.1 ESS64029.1 - 1.6e-20 72.4 5.6 2.7e-06 26.8 0.1 4.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.1 ESS64029.1 - 2.1e-19 69.4 2.8 3.3e-07 30.3 0.3 4.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 ESS64029.1 - 6e-16 56.4 4.3 1.4e-05 24.0 0.4 5.1 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 ESS64029.1 - 1e-15 56.1 5.6 0.002 17.8 0.0 5.4 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 ESS64029.1 - 0.0061 15.8 5.1 0.071 12.4 0.2 3.7 4 0 0 4 4 4 1 EF hand EF-hand_like PF09279.6 ESS64029.1 - 0.012 15.5 0.3 0.17 11.9 0.0 2.9 4 0 0 4 4 4 0 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_4 PF12763.2 ESS64029.1 - 0.014 15.1 0.3 0.31 10.7 0.0 2.7 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Sec7 PF01369.15 ESS64030.1 - 5.8e-41 140.2 0.0 1e-40 139.4 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain DUF773 PF05600.7 ESS64031.1 - 0.027 13.2 0.1 0.052 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF773) tRNA_Me_trans PF03054.11 ESS64032.1 - 8.8e-46 156.0 0.0 1.3e-35 122.6 0.0 3.8 3 1 0 3 3 3 3 tRNA methyl transferase Asn_synthase PF00733.16 ESS64032.1 - 0.00092 18.7 0.0 0.0023 17.4 0.0 1.8 1 1 0 1 1 1 1 Asparagine synthase ACP_syn_III PF08545.5 ESS64033.1 - 0.013 15.1 0.0 0.43 10.2 0.0 2.3 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1751 PF08551.5 ESS64034.1 - 4.1e-05 23.8 0.8 4.1e-05 23.8 0.5 2.1 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 ESS64034.1 - 0.14 12.1 13.1 0.014 15.4 5.2 2.2 1 1 0 1 1 1 0 Rhomboid family FH2 PF02181.18 ESS64035.1 - 8.5e-59 199.2 0.2 8.5e-59 199.2 0.2 1.7 2 0 0 2 2 2 1 Formin Homology 2 Domain DUF747 PF05346.6 ESS64036.1 - 2.6e-76 256.8 13.6 4e-76 256.2 9.4 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family Pkinase PF00069.20 ESS64037.1 - 1.6e-43 148.7 0.0 2.3e-42 144.9 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64037.1 - 3.2e-19 69.0 0.1 4.6e-15 55.3 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS64037.1 - 3e-05 23.1 0.0 9.9e-05 21.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESS64037.1 - 0.02 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESS64037.1 - 0.067 12.0 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 ESS64037.1 - 0.084 11.9 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2823 PF11034.3 ESS64037.1 - 0.2 11.8 0.3 0.38 10.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2823) Acyl-CoA_dh_1 PF00441.19 ESS64039.1 - 0.043 13.9 8.4 0.078 13.0 0.5 2.6 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain PLDc_2 PF13091.1 ESS64040.1 - 1.7e-07 31.0 0.1 0.0011 18.7 0.0 3.1 2 1 1 3 3 3 2 PLD-like domain Cytochrom_C PF00034.16 ESS64040.1 - 0.078 13.8 0.1 0.17 12.7 0.1 1.6 1 0 0 1 1 1 0 Cytochrome c PTPA PF03095.10 ESS64041.1 - 4.2e-100 334.7 0.0 4.8e-100 334.6 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Shugoshin_N PF07558.6 ESS64042.1 - 0.00081 19.0 0.6 0.0017 18.0 0.4 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.10 ESS64042.1 - 0.072 12.9 0.3 0.072 12.9 0.2 2.4 3 0 0 3 3 3 0 Basic region leucine zipper SHNi-TPR PF10516.4 ESS64042.1 - 0.13 11.5 0.5 0.35 10.1 0.4 1.7 1 0 0 1 1 1 0 SHNi-TPR Pkinase PF00069.20 ESS64043.1 - 1.7e-55 187.9 0.0 4.8e-54 183.2 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64043.1 - 4.7e-38 130.7 0.0 2.2e-22 79.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS64043.1 - 0.0013 17.7 0.0 0.22 10.4 0.0 2.9 3 0 0 3 3 3 2 Kinase-like Metal_resist PF13801.1 ESS64043.1 - 0.028 14.4 1.9 2.6 8.0 0.4 3.1 3 0 0 3 3 3 0 Heavy-metal resistance PX PF00787.19 ESS64044.1 - 0.0018 18.0 0.1 0.0018 18.0 0.0 1.6 2 0 0 2 2 2 1 PX domain EF-hand_7 PF13499.1 ESS64044.1 - 0.061 13.4 0.0 0.41 10.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 ESS64044.1 - 0.062 13.2 0.7 0.29 11.1 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain FH2 PF02181.18 ESS64044.1 - 0.087 11.6 1.2 0.16 10.8 0.9 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain EF-hand_1 PF00036.27 ESS64044.1 - 0.14 11.5 0.6 0.63 9.4 0.0 2.4 2 0 0 2 2 2 0 EF hand ABC_tran_2 PF12848.2 ESS64045.1 - 1.2 8.9 9.1 2.9 7.8 6.3 1.6 1 0 0 1 1 1 0 ABC transporter PLAC8 PF04749.12 ESS64046.1 - 0.00022 21.7 22.5 0.00022 21.7 15.6 2.4 2 1 0 2 2 2 1 PLAC8 family CIAPIN1 PF05093.8 ESS64047.1 - 4.4e-17 61.9 17.6 1e-15 57.6 12.2 2.1 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis ADH_N PF08240.7 ESS64047.1 - 6 6.6 8.2 0.26 11.0 0.3 2.0 1 1 1 2 2 2 0 Alcohol dehydrogenase GroES-like domain Proteasom_Rpn13 PF04683.8 ESS64050.1 - 5.7e-19 67.9 0.2 8.5e-19 67.4 0.1 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DNA_pol_E_B PF04042.11 ESS64053.1 - 6.9e-28 97.3 0.3 1.1e-27 96.6 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DTW PF03942.10 ESS64054.1 - 5.1e-27 94.4 0.0 7.5e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 DTW domain zf-B_box PF00643.19 ESS64054.1 - 0.072 12.9 0.8 0.13 12.1 0.5 1.4 1 0 0 1 1 1 0 B-box zinc finger GAS PF13851.1 ESS64055.1 - 5.5e-61 205.2 23.1 5.5e-61 205.2 16.0 3.0 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding Lysine_decarbox PF03641.9 ESS64056.1 - 0.086 12.6 0.0 0.23 11.2 0.0 1.7 2 0 0 2 2 2 0 Possible lysine decarboxylase Synaptobrevin PF00957.16 ESS64057.1 - 0.043 13.4 0.7 2.4 7.8 0.2 2.5 2 0 0 2 2 2 0 Synaptobrevin Med9 PF07544.8 ESS64057.1 - 0.17 11.6 1.2 0.52 10.0 0.8 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 MerR-DNA-bind PF09278.6 ESS64057.1 - 0.18 12.2 1.7 0.47 10.8 1.2 1.7 1 0 0 1 1 1 0 MerR, DNA binding Ribosomal_L18p PF00861.17 ESS64058.1 - 3.9e-35 120.6 0.5 3.9e-35 120.6 0.3 1.8 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 ESS64058.1 - 1.1e-23 83.6 5.6 1.7e-23 82.9 3.9 1.3 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Trypsin_2 PF13365.1 ESS64060.1 - 0.0031 17.4 0.0 0.007 16.3 0.0 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain TPR_12 PF13424.1 ESS64061.1 - 1.6e-12 47.1 20.2 1.1e-08 34.8 0.7 5.2 2 1 6 8 8 8 4 Tetratricopeptide repeat DUF2743 PF10899.3 ESS64061.1 - 0.012 14.9 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2743) TPR_8 PF13181.1 ESS64061.1 - 0.03 14.1 5.1 1.1 9.1 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESS64061.1 - 0.096 12.3 13.2 0.1 12.2 0.2 4.3 3 1 2 5 5 5 0 TPR repeat TPR_1 PF00515.23 ESS64061.1 - 2.8 7.7 11.7 22 4.8 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS64061.1 - 9.2 6.4 16.0 56 4.0 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat U3_assoc_6 PF08640.6 ESS64062.1 - 8.7e-17 60.6 0.1 3.8e-16 58.5 0.0 2.1 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 Ribosomal_S6e PF01092.14 ESS64064.1 - 1.8e-41 140.7 2.0 2e-41 140.5 0.2 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e RmlD_sub_bind PF04321.12 ESS64065.1 - 3.6e-05 22.8 0.0 0.034 13.0 0.0 2.3 2 1 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.1 ESS64065.1 - 0.00025 21.0 0.0 0.00047 20.2 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding EF-hand_1 PF00036.27 ESS64066.1 - 1.6e-12 45.7 1.1 1.2e-06 27.4 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 ESS64066.1 - 3.8e-11 41.9 1.7 2.6e-05 23.7 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESS64066.1 - 1.2e-10 41.3 1.5 4.8e-09 36.2 0.3 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 ESS64066.1 - 1.9e-09 36.3 1.4 2.9e-05 23.2 0.1 3.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 ESS64066.1 - 9.6e-06 25.1 1.3 0.0059 16.1 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 ESS64066.1 - 0.095 12.7 0.3 5.4 7.0 0.0 2.8 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Ank_2 PF12796.2 ESS64067.1 - 6.3e-92 302.0 18.1 7.4e-15 55.0 1.0 14.8 8 5 6 14 14 14 12 Ankyrin repeats (3 copies) Ank PF00023.25 ESS64067.1 - 1.8e-60 197.9 59.4 1.4e-07 30.9 0.0 23.2 23 0 0 23 23 23 15 Ankyrin repeat Ank_4 PF13637.1 ESS64067.1 - 3.2e-59 196.3 35.3 4.2e-08 33.4 0.1 18.4 16 5 4 20 20 20 11 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESS64067.1 - 3.3e-46 154.2 48.3 2.6e-08 33.8 0.2 19.2 15 5 6 21 21 21 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS64067.1 - 2.5e-43 141.7 41.3 6.8e-05 22.7 0.0 22.4 24 0 0 24 24 24 10 Ankyrin repeat CYTH PF01928.16 ESS64068.1 - 0.0022 17.6 0.0 0.0039 16.8 0.0 1.5 1 0 0 1 1 1 1 CYTH domain SH3_9 PF14604.1 ESS64071.1 - 2.2e-32 110.3 2.3 2.4e-14 52.6 0.0 4.0 4 1 0 4 4 4 3 Variant SH3 domain SH3_1 PF00018.23 ESS64071.1 - 5e-30 102.6 0.2 9.2e-12 44.1 0.0 3.3 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.12 ESS64071.1 - 3.5e-28 96.8 0.3 2.2e-11 43.0 0.0 3.2 3 0 0 3 3 3 3 Variant SH3 domain zf-DHHC PF01529.15 ESS64071.1 - 0.047 13.0 0.5 0.079 12.3 0.4 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase PA-IL PF07828.7 ESS64071.1 - 0.072 12.8 0.0 0.54 10.0 0.0 2.1 2 0 0 2 2 2 0 PA-IL-like protein DUF4205 PF13898.1 ESS64072.1 - 2.1e-26 92.4 0.0 4.7e-26 91.3 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4205) E1-E2_ATPase PF00122.15 ESS64073.1 - 6.7e-63 211.8 3.5 1.3e-62 210.8 1.4 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESS64073.1 - 1.9e-29 102.4 8.2 1.9e-29 102.4 5.7 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESS64073.1 - 1.6e-21 77.6 0.0 2.7e-20 73.7 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS64073.1 - 4.8e-16 58.4 0.0 1.3e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESS64073.1 - 1.4e-09 38.4 0.4 1.2e-08 35.3 0.0 2.8 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESS64073.1 - 3.4e-05 23.2 0.0 6.6e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESS64073.1 - 0.0001 21.9 0.4 0.00018 21.1 0.3 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Sec31 PF11549.3 ESS64073.1 - 0.058 13.0 0.0 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein transport protein SEC31 Kinesin PF00225.18 ESS64074.1 - 1.5e-73 247.4 0.1 2.9e-43 147.8 0.0 2.5 3 0 0 3 3 3 2 Kinesin motor domain DUF3135 PF11333.3 ESS64075.1 - 0.0021 18.1 0.0 0.0069 16.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3135) DUF717 PF05338.7 ESS64075.1 - 0.0085 16.0 0.7 0.016 15.1 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF717) DUF2197 PF09963.4 ESS64075.1 - 0.18 11.7 0.0 0.18 11.7 0.0 3.7 4 1 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-C3HC4_3 PF13920.1 ESS64075.1 - 7.5 6.3 13.2 6.3 6.5 3.3 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) STOP PF05217.7 ESS64076.1 - 1.5e-05 24.8 13.8 3.1e-05 23.8 2.8 2.5 1 1 1 2 2 2 2 STOP protein ArfGap PF01412.13 ESS64077.1 - 1.3e-30 105.5 0.9 1.6e-30 105.2 0.1 1.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SirB PF04247.7 ESS64078.1 - 0.49 10.1 3.8 0.68 9.6 2.6 1.2 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB ATP11 PF06644.6 ESS64079.1 - 6.3e-24 84.9 1.6 8.1e-24 84.5 1.1 1.1 1 0 0 1 1 1 1 ATP11 protein Ribosomal_L32e PF01655.13 ESS64080.1 - 7.9e-42 141.7 0.5 9.5e-42 141.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 DUF1436 PF07262.6 ESS64080.1 - 0.075 12.5 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) Pox_TAP PF03355.9 ESS64081.1 - 0.14 11.4 0.1 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Viral Trans-Activator Protein Ribosomal_L36e PF01158.13 ESS64082.1 - 7.4e-34 115.6 5.6 8.5e-34 115.4 3.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e BTB PF00651.26 ESS64084.1 - 1.1e-11 44.7 0.1 7.1e-05 22.7 0.0 2.8 2 1 0 2 2 2 2 BTB/POZ domain MATH PF00917.21 ESS64084.1 - 0.0017 18.6 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 MATH domain GDE_N_bis PF14742.1 ESS64084.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of (some) glycogen debranching enzymes Spectrin PF00435.16 ESS64085.1 - 0.0019 18.4 0.4 0.0019 18.4 0.3 3.1 3 1 0 3 3 3 1 Spectrin repeat zf-primase PF09329.6 ESS64086.1 - 2.7e-10 39.6 0.2 7.4e-10 38.2 0.1 1.8 1 0 0 1 1 1 1 Primase zinc finger Mcm10 PF09332.6 ESS64086.1 - 6.5e-08 32.3 5.9 1.6e-07 31.0 4.0 1.6 1 1 0 1 1 1 1 Mcm10 replication factor fn3 PF00041.16 ESS64087.1 - 3.2e-114 373.2 57.3 1.5e-06 28.2 0.4 38.0 37 4 0 37 37 37 29 Fibronectin type III domain Interfer-bind PF09294.5 ESS64087.1 - 5.3e-16 58.5 15.0 0.58 10.2 0.0 14.0 16 0 0 16 16 16 7 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.4 ESS64087.1 - 0.24 10.4 3.7 4.8 6.1 0.0 4.6 6 0 0 6 6 6 0 Uncharacterised conserved protein (DUF2369) HECT PF00632.20 ESS64088.1 - 4.7e-38 131.1 0.0 8e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESS64088.1 - 2e-10 40.8 0.0 3.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-RanBP PF00641.13 ESS64089.1 - 7.2e-05 21.8 1.3 7.2e-05 21.8 0.9 3.2 1 1 1 2 2 2 1 Zn-finger in Ran binding protein and others DUF1724 PF08350.5 ESS64092.1 - 0.033 13.7 0.5 0.77 9.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1724) Sec1 PF00995.18 ESS64093.1 - 1.8e-86 291.0 0.0 2.1e-86 290.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF3726 PF12525.3 ESS64093.1 - 0.032 14.0 0.5 0.13 12.0 0.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3726) LEAP-2 PF07359.6 ESS64094.1 - 4.6 6.9 8.2 2.4 7.8 2.7 2.5 2 1 1 3 3 3 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) WD40 PF00400.27 ESS64095.1 - 1.3e-19 69.2 3.4 2.9e-06 26.9 0.3 4.6 4 1 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.1 ESS64095.1 - 0.0047 17.1 0.0 0.71 10.2 0.0 3.8 4 0 0 4 4 4 1 PQQ-like domain TFIIA PF03153.8 ESS64095.1 - 0.011 15.7 15.2 0.016 15.1 10.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VID27 PF08553.5 ESS64095.1 - 0.063 11.5 10.4 0.086 11.0 7.2 1.2 1 0 0 1 1 1 0 VID27 cytoplasmic protein BUD22 PF09073.5 ESS64095.1 - 0.13 11.3 27.2 0.25 10.3 18.8 1.4 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.7 ESS64095.1 - 0.47 8.3 30.7 0.67 7.8 21.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 ESS64095.1 - 0.7 8.5 26.6 1.3 7.6 18.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Daxx PF03344.10 ESS64095.1 - 0.7 8.3 34.1 1.3 7.3 23.6 1.4 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 ESS64095.1 - 0.75 9.0 34.0 1.2 8.3 23.6 1.2 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.7 ESS64095.1 - 1.2 8.3 12.8 2.1 7.5 8.9 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.9 ESS64095.1 - 6 4.7 27.4 8.9 4.2 19.0 1.2 1 0 0 1 1 1 0 CDC45-like protein BTV_NS2 PF04514.7 ESS64095.1 - 7.4 5.3 19.2 12 4.6 13.3 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF3584 PF12128.3 ESS64097.1 - 0.00048 17.6 21.9 0.00048 17.6 15.2 3.8 1 1 1 3 3 3 1 Protein of unknown function (DUF3584) BLOC1_2 PF10046.4 ESS64097.1 - 0.0007 19.6 40.5 0.04 14.0 0.8 8.8 6 3 4 11 11 11 4 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.7 ESS64097.1 - 0.0025 17.6 29.8 0.076 12.8 0.2 7.9 4 3 4 9 9 9 3 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 ESS64097.1 - 0.0029 16.8 22.1 0.25 10.5 0.0 6.5 2 2 5 7 7 7 3 Reovirus sigma C capsid protein NPV_P10 PF05531.7 ESS64097.1 - 0.31 11.2 21.7 5.8 7.2 0.1 8.3 7 4 1 8 8 8 0 Nucleopolyhedrovirus P10 protein FUSC PF04632.7 ESS64097.1 - 0.43 8.9 19.9 0.57 8.5 2.6 3.7 2 1 1 3 3 3 0 Fusaric acid resistance protein family ApoO PF09769.4 ESS64097.1 - 2.6 7.7 17.5 21 4.8 0.3 6.1 6 1 0 6 6 6 0 Apolipoprotein O Lipase PF00151.14 ESS64098.1 - 0.048 12.8 0.0 0.067 12.3 0.0 1.1 1 0 0 1 1 1 0 Lipase CN_hydrolase PF00795.17 ESS64099.1 - 1.6e-31 109.0 0.0 2.2e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF2826 PF11442.3 ESS64100.1 - 7.5e-72 240.2 5.9 1.4e-71 239.3 4.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2826) DUF1176 PF06674.6 ESS64101.1 - 0.18 10.8 1.9 0.23 10.5 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1176) Sec1 PF00995.18 ESS64103.1 - 2e-07 30.0 0.0 2.8e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Sec1 family DUF4583 PF15190.1 ESS64103.1 - 0.083 12.5 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4583) Nucleoplasmin PF03066.10 ESS64105.1 - 2 7.9 15.5 0.1 12.0 6.7 1.9 2 0 0 2 2 2 0 Nucleoplasmin Laminin_G_3 PF13385.1 ESS64107.1 - 1.5e-06 28.5 0.0 2.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS64107.1 - 0.032 13.2 0.0 0.064 12.3 0.0 1.5 1 0 0 1 1 1 0 BNR repeat-like domain Mucin PF01456.12 ESS64108.1 - 0.0012 18.6 19.1 0.0038 17.0 13.2 1.8 1 1 0 1 1 1 1 Mucin-like glycoprotein DGF-1_5 PF11038.3 ESS64109.1 - 3.3e-96 321.7 19.4 3.3e-96 321.7 13.4 2.8 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS64109.1 - 2.2e-45 152.4 1.4 2.2e-45 152.4 1.0 2.3 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS64109.1 - 3.5e-33 113.8 15.7 3.5e-33 113.8 10.9 2.3 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 BNR_3 PF13859.1 ESS64112.1 - 1.8e-131 437.8 4.2 1.8e-131 437.8 2.9 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS64112.1 - 4.4e-18 66.0 0.9 1.3e-17 64.4 0.7 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS64112.1 - 3.4e-07 29.9 12.1 8e-07 28.8 8.4 1.7 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS64119.1 - 3.5e-130 433.6 2.5 4.6e-130 433.2 1.7 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS64119.1 - 0.0033 16.7 0.0 0.004 16.4 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BssS PF13991.1 ESS64119.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 BssS protein family BNR_3 PF13859.1 ESS64120.1 - 3.2e-62 210.3 0.2 6.8e-62 209.3 0.2 1.6 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS64120.1 - 2.2e-16 60.4 2.4 2.2e-16 60.4 1.6 2.4 3 1 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS64120.1 - 3.8e-10 39.4 11.1 3.8e-10 39.4 7.7 2.4 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal DUF3720 PF12517.3 ESS64121.1 - 1.6e-22 80.0 16.5 1.6e-22 80.0 11.4 4.0 1 1 3 4 4 4 1 Protein of unknown function (DUF3720) FlbD PF06289.6 ESS64121.1 - 0.099 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Flagellar protein (FlbD) vATP-synt_E PF01991.13 ESS64121.1 - 8.2 5.6 13.0 14 4.8 9.0 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Herpes_DNAp_acc PF04929.7 ESS64122.1 - 0.028 13.3 0.9 0.048 12.6 0.6 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor FAD_binding_2 PF00890.19 ESS64124.1 - 9.3e-15 54.3 0.0 1.3e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 ESS64124.1 - 5.2e-10 39.8 0.0 1.1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESS64124.1 - 0.087 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain ApbE PF02424.10 ESS64125.1 - 2.6e-60 203.8 0.0 3.9e-60 203.2 0.0 1.2 1 0 0 1 1 1 1 ApbE family NAD_binding_1 PF00175.16 ESS64125.1 - 9.9e-17 61.4 0.0 2.4e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_2 PF00890.19 ESS64125.1 - 1.1e-15 57.3 0.0 1.9e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_6 PF00970.19 ESS64125.1 - 2.3e-09 37.2 0.0 6e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESS64125.1 - 1.6e-06 28.1 0.2 0.0021 18.0 0.0 2.7 3 0 0 3 3 3 2 Ferric reductase NAD binding domain Rhodanese PF00581.15 ESS64126.1 - 2.2e-11 44.0 0.0 4.5e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain STT3 PF02516.9 ESS64127.1 - 6.8e-49 167.1 26.7 1.5e-46 159.4 16.8 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Kri1_C PF12936.2 ESS64130.1 - 1.4e-23 82.6 0.5 1.4e-23 82.6 0.3 2.9 3 0 0 3 3 3 1 KRI1-like family C-terminal Kri1 PF05178.7 ESS64130.1 - 7e-23 80.8 14.8 7e-23 80.8 10.3 5.5 6 0 0 6 6 6 1 KRI1-like family TIMELESS PF04821.9 ESS64131.1 - 0.11 11.6 0.3 0.23 10.6 0.2 1.5 1 0 0 1 1 1 0 Timeless protein FAM176 PF14851.1 ESS64131.1 - 1.1 8.8 6.3 0.22 11.2 0.1 2.6 3 0 0 3 3 3 0 FAM176 family Pkinase PF00069.20 ESS64133.1 - 1.3e-67 227.7 0.0 2e-67 227.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64133.1 - 2.7e-25 88.9 0.0 4.4e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS64133.1 - 0.0013 17.7 0.1 0.38 9.6 0.0 3.0 2 1 0 3 3 3 2 Kinase-like Pkinase PF00069.20 ESS64136.1 - 1.9e-53 181.2 0.0 2.3e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64136.1 - 6e-36 123.8 0.0 7.7e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS64136.1 - 5e-07 28.9 0.0 7.9e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SH3_3 PF08239.6 ESS64136.1 - 4.4e-06 26.7 0.0 8.9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain PQQ_3 PF13570.1 ESS64137.1 - 5.4e-06 26.4 2.1 0.0054 16.9 0.0 4.4 3 1 1 4 4 4 1 PQQ-like domain WD40 PF00400.27 ESS64137.1 - 1.1e-05 25.1 11.0 0.00067 19.4 0.0 5.0 6 0 0 6 6 6 3 WD domain, G-beta repeat DUF3366 PF11846.3 ESS64139.1 - 0.038 13.8 0.0 0.081 12.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3366) SPX PF03105.14 ESS64140.1 - 7.9e-18 65.2 13.2 2.3e-10 40.7 0.8 3.6 3 1 1 4 4 4 3 SPX domain Na_sulph_symp PF00939.14 ESS64141.1 - 4.2e-15 55.5 28.6 6.9e-13 48.2 16.6 2.0 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 ESS64141.1 - 2.7e-06 26.2 8.8 2.7e-06 26.2 6.1 2.9 2 1 1 3 3 3 2 Citrate transporter DUF3681 PF12442.3 ESS64142.1 - 0.22 11.7 3.0 3.6 7.8 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3681) Dor1 PF04124.7 ESS64143.1 - 1.5e-18 66.3 0.6 2.2e-18 65.8 0.4 1.1 1 0 0 1 1 1 1 Dor1-like family P3A PF08727.6 ESS64144.1 - 0.1 11.9 0.1 0.22 10.8 0.1 1.5 1 0 0 1 1 1 0 Poliovirus 3A protein like DHC_N2 PF08393.8 ESS64145.1 - 3.1e-96 322.3 6.1 7.3e-96 321.1 4.2 1.7 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS64145.1 - 6.5e-85 284.3 0.0 2.4e-84 282.4 0.0 1.9 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 ESS64145.1 - 5.6e-16 58.5 0.1 1.4e-07 31.2 0.0 4.0 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS64145.1 - 1.7e-05 24.4 0.3 0.18 11.5 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain AAA PF00004.24 ESS64145.1 - 4e-05 23.8 0.1 0.024 14.8 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ESS64145.1 - 0.00015 21.9 0.0 0.096 12.8 0.0 3.3 3 0 0 3 3 2 1 RNA helicase AAA_22 PF13401.1 ESS64145.1 - 0.00017 21.6 0.5 0.79 9.8 0.0 4.6 4 0 0 4 4 4 1 AAA domain AAA_17 PF13207.1 ESS64145.1 - 0.00037 21.2 0.2 0.16 12.7 0.0 4.1 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 ESS64145.1 - 0.00046 20.5 0.0 0.58 10.4 0.0 3.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESS64145.1 - 0.001 19.0 0.2 0.19 11.7 0.0 3.2 3 0 0 3 3 2 1 AAA ATPase domain DUF853 PF05872.7 ESS64145.1 - 0.02 13.2 0.5 1.3 7.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) AAA_30 PF13604.1 ESS64145.1 - 0.037 13.5 0.4 2.8 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESS64145.1 - 0.038 13.9 0.0 0.27 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 ESS64145.1 - 0.13 11.7 0.6 10 5.5 0.1 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_7 PF12775.2 ESS64146.1 - 1.2e-34 119.7 0.0 1.4e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESS64146.1 - 0.017 14.8 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.10 ESS64147.1 - 1.7e-192 641.2 0.0 5.3e-192 639.6 0.0 1.8 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 ESS64147.1 - 1.5e-43 148.7 0.0 3e-43 147.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS64147.1 - 8.8e-43 145.7 1.6 1.8e-41 141.5 0.4 3.0 2 1 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS64147.1 - 2.9e-35 121.6 7.2 5.2e-35 120.8 5.0 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Ldh_1_C PF02866.13 ESS64148.1 - 8e-33 113.6 0.0 2e-32 112.3 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 ESS64148.1 - 2.2e-29 102.0 0.0 3.5e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain F-box PF00646.28 ESS64150.1 - 1.4 8.6 5.6 0.28 10.8 0.5 2.3 3 0 0 3 3 3 0 F-box domain SlyX PF04102.7 ESS64151.1 - 4.3e-06 27.0 8.8 0.00048 20.4 1.2 2.6 2 0 0 2 2 2 2 SlyX zf-RING_2 PF13639.1 ESS64151.1 - 0.0078 16.0 6.0 0.019 14.7 3.1 2.3 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESS64151.1 - 0.025 14.2 6.6 0.054 13.1 0.8 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zwint PF15556.1 ESS64151.1 - 0.026 13.7 5.9 0.046 12.9 4.1 1.4 1 0 0 1 1 1 0 ZW10 interactor Mod_r PF07200.8 ESS64151.1 - 0.036 13.9 7.5 0.78 9.6 0.1 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein BUD22 PF09073.5 ESS64151.1 - 0.077 12.0 11.9 0.11 11.6 8.3 1.1 1 0 0 1 1 1 0 BUD22 Adeno_PIX PF03955.9 ESS64151.1 - 0.12 12.8 0.2 1 9.9 0.0 2.3 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) TMF_DNA_bd PF12329.3 ESS64151.1 - 0.4 10.5 5.1 1.3 8.9 0.9 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-Apc11 PF12861.2 ESS64151.1 - 0.41 10.5 2.0 1.2 8.9 0.2 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DivIC PF04977.10 ESS64151.1 - 0.71 9.4 3.7 4.7 6.7 0.1 2.4 2 0 0 2 2 2 0 Septum formation initiator zf-C3HC4 PF00097.20 ESS64151.1 - 1.1 8.9 5.2 0.47 10.1 0.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ADIP PF11559.3 ESS64151.1 - 3.5 7.5 16.1 1.2 9.0 1.2 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding zf-C3HC4_2 PF13923.1 ESS64151.1 - 5.6 7.0 7.6 0.36 10.9 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HSP70 PF00012.15 ESS64153.1 - 7e-200 664.9 3.6 8.7e-200 664.6 2.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESS64153.1 - 8.4e-12 44.3 2.2 4e-10 38.8 0.4 2.4 2 0 0 2 2 2 2 MreB/Mbl protein BcrAD_BadFG PF01869.15 ESS64153.1 - 0.00046 19.5 0.1 0.027 13.7 0.0 3.1 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Hep_59 PF07052.6 ESS64153.1 - 0.024 15.0 2.2 5.3 7.4 0.3 2.9 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 DUF4611 PF15387.1 ESS64153.1 - 0.039 14.1 1.4 0.14 12.3 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FtsA PF14450.1 ESS64153.1 - 0.046 13.5 5.6 0.064 13.0 0.0 3.6 3 2 0 3 3 3 0 Cell division protein FtsA DUF4455 PF14643.1 ESS64153.1 - 0.054 12.1 2.5 0.098 11.2 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) FGGY_C PF02782.11 ESS64153.1 - 0.059 12.9 0.1 0.14 11.7 0.1 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Orbi_NS1 PF01718.11 ESS64153.1 - 0.1 10.5 0.1 0.24 9.3 0.0 1.6 2 0 0 2 2 2 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein Hydantoinase_A PF01968.13 ESS64153.1 - 0.75 8.8 6.2 2.9 6.8 0.3 3.0 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase Prominin PF05478.6 ESS64154.1 - 0.27 8.7 2.8 0.35 8.3 1.9 1.2 1 0 0 1 1 1 0 Prominin Beta-lactamase PF00144.19 ESS64155.1 - 3.3e-05 23.0 0.0 0.041 12.8 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase DUF2804 PF10974.3 ESS64156.1 - 4.6e-53 180.2 0.1 5.5e-53 179.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2804) Glyco_transf_36 PF06165.6 ESS64156.1 - 0.12 12.2 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 36 HALZ PF02183.13 ESS64157.1 - 0.47 10.2 33.7 0.28 10.9 0.2 6.6 5 1 1 6 6 6 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.4 ESS64157.1 - 7.3 6.5 49.3 0.44 10.5 8.5 4.5 3 1 0 4 4 4 0 JNK_SAPK-associated protein-1 HSP70 PF00012.15 ESS64159.1 - 3.9e-176 586.5 1.7 4.7e-176 586.2 1.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESS64159.1 - 4.6e-08 32.0 0.0 8.4e-08 31.1 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.11 ESS64159.1 - 0.00014 21.5 0.1 0.00071 19.2 0.0 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 ESS64159.1 - 0.022 13.6 0.3 1.6 7.4 0.0 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 ESS64159.1 - 0.033 13.2 2.9 2.7 7.0 0.1 2.8 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase Spc97_Spc98 PF04130.8 ESS64160.1 - 1.4e-75 254.6 5.2 2.1e-75 254.1 3.6 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family AAA PF00004.24 ESS64161.1 - 1.1e-10 41.8 0.0 4.2e-09 36.6 0.0 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 ESS64161.1 - 0.014 14.8 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 ESS64161.1 - 0.014 14.7 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESS64161.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain IPT PF01745.11 ESS64161.1 - 0.02 14.0 0.0 0.086 12.0 0.0 1.8 2 0 0 2 2 2 0 Isopentenyl transferase AAA_17 PF13207.1 ESS64161.1 - 0.024 15.4 0.1 0.11 13.2 0.0 2.0 2 1 0 2 2 1 0 AAA domain AAA_5 PF07728.9 ESS64161.1 - 0.035 13.8 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PPV_E1_C PF00519.12 ESS64161.1 - 0.041 12.5 0.0 0.059 11.9 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase AAA_22 PF13401.1 ESS64161.1 - 0.053 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS64161.1 - 0.055 13.4 0.1 0.17 11.8 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 ESS64161.1 - 0.073 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain RNA_helicase PF00910.17 ESS64161.1 - 0.086 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.1 ESS64161.1 - 0.088 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 ESS64162.1 - 1.6e-58 192.6 20.1 2.4e-11 43.0 0.0 7.4 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESS64162.1 - 2e-06 26.2 6.0 0.0022 16.2 0.1 4.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF1513 PF07433.6 ESS64162.1 - 0.0002 20.3 0.0 0.085 11.7 0.0 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF1513) PD40 PF07676.7 ESS64162.1 - 0.0015 18.1 0.3 5.4 6.8 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.6 ESS64162.1 - 0.09 11.5 0.3 1.3 7.6 0.2 2.8 1 1 0 1 1 1 0 Nup133 N terminal like DUF179 PF02622.10 ESS64163.1 - 0.00026 20.6 0.0 0.0018 17.9 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 2OG-FeII_Oxy_2 PF13532.1 ESS64164.1 - 1.4e-07 31.5 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ribosomal_L14e PF01929.12 ESS64166.1 - 1.5e-23 82.9 6.1 1.5e-23 82.9 4.2 2.1 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.24 ESS64166.1 - 8.9e-06 25.2 2.4 1.7e-05 24.2 1.6 1.5 1 0 0 1 1 1 1 KOW motif Cytochrom_B562 PF07361.6 ESS64167.1 - 0.051 13.9 1.3 0.051 13.9 0.9 1.6 2 0 0 2 2 2 0 Cytochrome b562 HR1 PF02185.11 ESS64167.1 - 0.09 12.5 0.5 0.09 12.5 0.4 3.1 3 0 0 3 3 3 0 Hr1 repeat Med9 PF07544.8 ESS64167.1 - 0.098 12.3 1.5 0.66 9.7 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TSC22 PF01166.13 ESS64167.1 - 0.2 11.6 9.1 0.44 10.5 0.6 2.7 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF1690 PF07956.6 ESS64167.1 - 0.85 9.5 6.5 0.67 9.9 2.4 2.0 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) DivIC PF04977.10 ESS64167.1 - 1.9 8.0 5.9 2.5 7.6 0.1 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF3782 PF12644.2 ESS64167.1 - 7.1 6.5 7.5 6.3 6.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) Acetyltransf_1 PF00583.19 ESS64168.1 - 2.7e-17 62.5 0.0 4.8e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESS64168.1 - 9.7e-13 48.0 0.0 1.3e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESS64168.1 - 3.2e-07 30.2 0.0 4.6e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESS64168.1 - 1.6e-06 28.2 0.0 2e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESS64168.1 - 6.2e-05 22.6 0.0 0.00016 21.3 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 ESS64168.1 - 0.00014 21.6 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.1 ESS64168.1 - 0.0022 17.9 0.0 0.003 17.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESS64168.1 - 0.0026 17.9 0.0 0.0034 17.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain HTH_20 PF12840.2 ESS64168.1 - 0.063 13.1 0.9 0.22 11.3 0.2 2.1 1 1 1 2 2 2 0 Helix-turn-helix domain Acetyltransf_8 PF13523.1 ESS64168.1 - 0.067 13.0 0.0 0.095 12.5 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain APG12 PF04110.8 ESS64169.1 - 1.8e-05 24.8 0.0 2.1e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Beta_helix PF13229.1 ESS64173.1 - 4.5e-08 33.0 0.1 0.00031 20.5 0.0 3.1 2 2 0 2 2 2 2 Right handed beta helix region Coiled-coil_56 PF09813.4 ESS64173.1 - 0.098 12.6 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 DUF4246 PF14033.1 ESS64173.1 - 0.29 9.6 0.1 0.43 9.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) PhyH PF05721.8 ESS64174.1 - 1.8e-35 122.8 0.0 2.4e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF563 PF04577.9 ESS64175.1 - 5.3e-27 95.0 0.1 1.4e-26 93.7 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF563) SET PF00856.23 ESS64176.1 - 0.1 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 SET domain ETS_PEA3_N PF04621.8 ESS64178.1 - 1.4 8.0 5.8 2.1 7.5 4.0 1.3 1 1 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain RNB PF00773.14 ESS64179.1 - 1.6e-64 218.2 0.0 2.3e-64 217.7 0.0 1.2 1 0 0 1 1 1 1 RNB domain TBPIP PF07106.8 ESS64180.1 - 0.094 12.2 0.0 0.2 11.1 0.0 1.5 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ADH_N PF08240.7 ESS64181.1 - 4.1e-07 29.7 0.2 7.7e-07 28.8 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESS64181.1 - 0.00013 21.5 0.0 0.00048 19.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase A_deaminase PF00962.17 ESS64182.1 - 2.6e-67 227.0 0.0 3.8e-67 226.5 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase OmpH PF03938.9 ESS64182.1 - 6.8 6.6 21.7 1.5 8.6 7.2 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) A_deaminase PF00962.17 ESS64183.1 - 3.3e-17 62.3 0.0 5.2e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF4168 PF13767.1 ESS64183.1 - 0.087 13.4 0.0 0.27 11.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4168) MRP-L47 PF06984.8 ESS64184.1 - 3.6e-26 90.8 0.2 7.3e-26 89.9 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GRIM-19 PF06212.7 ESS64184.1 - 0.062 13.0 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 GRIM-19 protein PseudoU_synth_2 PF00849.17 ESS64185.1 - 2e-13 50.4 0.0 6.3e-13 48.8 0.0 1.8 2 0 0 2 2 2 1 RNA pseudouridylate synthase GRAM PF02893.15 ESS64186.1 - 3.5e-06 26.4 0.0 6.5e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 GRAM domain GAS2 PF02187.12 ESS64187.1 - 0.074 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain Zein-binding PF04576.10 ESS64187.1 - 0.099 12.7 8.3 0.064 13.3 3.8 2.2 2 0 0 2 2 2 0 Zein-binding Mnd1 PF03962.10 ESS64187.1 - 9.9 5.7 18.5 0.11 12.1 4.8 2.3 2 0 0 2 2 2 0 Mnd1 family DUF2207 PF09972.4 ESS64189.1 - 0.22 10.0 0.0 0.29 9.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Cut8_M PF14483.1 ESS64191.1 - 0.17 11.7 2.0 6 6.7 0.1 2.5 2 0 0 2 2 2 0 Cut8 dimerisation domain TPR_6 PF13174.1 ESS64191.1 - 0.19 12.2 1.4 22 5.7 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Methyltransf_18 PF12847.2 ESS64193.1 - 1.3e-05 25.7 0.0 1.9e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS64193.1 - 0.001 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS64193.1 - 0.0043 17.4 0.0 0.011 16.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain TFIIIC_sub6 PF10419.4 ESS64194.1 - 0.1 12.0 1.8 9.6 5.7 0.1 3.3 4 0 0 4 4 4 0 TFIIIC subunit Ribosomal_L34e PF01199.13 ESS64194.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L34e DUF3302 PF11742.3 ESS64195.1 - 1.2 8.9 3.7 0.57 10.0 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3302) Topo_C_assoc PF14370.1 ESS64196.1 - 1.8e-28 97.9 0.1 2.7e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 C-terminal topoisomerase domain CDC45 PF02724.9 ESS64196.1 - 0.11 10.5 6.5 0.12 10.3 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RAP1 PF07218.6 ESS64196.1 - 0.53 8.3 5.1 0.61 8.1 3.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.4 ESS64196.1 - 0.66 8.1 3.8 0.75 8.0 2.6 1.1 1 0 0 1 1 1 0 Transmembrane protein Tmemb_cc2 PF10267.4 ESS64196.1 - 1.8 7.0 7.3 2.4 6.6 5.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SDA1 PF05285.7 ESS64196.1 - 2.1 7.5 9.4 3 7.0 6.5 1.3 1 0 0 1 1 1 0 SDA1 PDEase_I PF00233.14 ESS64197.1 - 2.1e-13 50.5 0.0 3.6e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF918 PF06033.6 ESS64197.1 - 0.0021 17.6 0.5 0.0044 16.5 0.4 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF918) Exo_endo_phos PF03372.18 ESS64198.1 - 1.8e-16 60.8 0.0 5.7e-16 59.2 0.0 1.8 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.11 ESS64204.1 - 1.8e-16 59.7 40.1 1.1e-11 44.0 15.6 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily Nodulin-like PF06813.8 ESS64204.1 - 1.4e-10 40.9 20.5 2.1e-09 36.9 14.2 2.5 1 1 0 1 1 1 1 Nodulin-like PQQ_3 PF13570.1 ESS64205.1 - 0.13 12.5 0.8 81 3.6 0.0 3.6 3 0 0 3 3 3 0 PQQ-like domain RabGAP-TBC PF00566.13 ESS64207.1 - 9.4e-46 155.9 0.2 1.3e-45 155.5 0.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain WD40 PF00400.27 ESS64208.1 - 0.0015 18.3 0.3 0.091 12.6 0.0 3.5 3 0 0 3 3 3 1 WD domain, G-beta repeat XPC-binding PF09280.6 ESS64209.1 - 1.2e-07 31.0 6.0 2e-07 30.3 3.6 1.8 1 1 0 1 1 1 1 XPC-binding domain UBA PF00627.26 ESS64209.1 - 2.7e-07 30.1 0.1 2.7e-07 30.1 0.1 2.3 3 0 0 3 3 3 1 UBA/TS-N domain DUF1676 PF07898.8 ESS64209.1 - 0.17 12.2 4.5 0.13 12.5 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) GvpL_GvpF PF06386.6 ESS64209.1 - 0.56 9.7 11.8 0.024 14.2 4.1 1.7 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF DUF4559 PF15112.1 ESS64209.1 - 1.6 7.7 4.4 2.5 7.1 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) MDMPI_N PF11716.3 ESS64209.1 - 4.7 7.6 7.9 1.8 9.0 2.8 2.3 2 1 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain EMP70 PF02990.11 ESS64211.1 - 2.2e-149 498.2 5.6 2.7e-149 498.0 3.9 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 SYS1 PF09801.4 ESS64212.1 - 3.1e-29 101.8 7.3 3.9e-29 101.4 5.1 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF4243 PF14027.1 ESS64212.1 - 0.0094 15.4 0.7 0.013 14.9 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) DUF4281 PF14108.1 ESS64212.1 - 0.54 10.3 6.9 3.4 7.7 0.7 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4281) dsrm PF00035.20 ESS64214.1 - 3.1e-10 40.4 1.4 0.012 16.1 0.1 4.2 3 1 0 3 3 3 3 Double-stranded RNA binding motif RINGv PF12906.2 ESS64215.1 - 7.7e-11 41.8 7.7 1.6e-10 40.8 5.3 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 ESS64215.1 - 0.00039 20.1 4.7 0.0009 19.0 3.3 1.7 1 0 0 1 1 1 1 Ring finger domain ADK_lid PF05191.9 ESS64215.1 - 0.0056 16.3 0.1 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid zf-RING-like PF08746.6 ESS64215.1 - 0.16 12.0 2.2 0.31 11.0 1.5 1.5 1 0 0 1 1 1 0 RING-like domain Radial_spoke PF04712.7 ESS64215.1 - 1.2 7.7 12.5 2.4 6.8 4.0 2.1 2 0 0 2 2 2 0 Radial spokehead-like protein PBP1_TM PF14812.1 ESS64215.1 - 4.8 7.5 16.5 0.15 12.3 4.6 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ABC_tran PF00005.22 ESS64216.1 - 1.7e-27 96.3 0.0 2.7e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS64216.1 - 4.9e-09 36.5 0.4 2.9e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 ESS64216.1 - 0.0028 17.5 0.8 0.062 13.2 0.1 2.9 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 ESS64216.1 - 0.011 14.9 0.3 0.19 10.9 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESS64216.1 - 0.067 12.7 0.2 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 ESS64216.1 - 0.092 12.5 0.5 0.77 9.5 0.2 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_25 PF13481.1 ESS64216.1 - 0.13 11.6 0.2 0.67 9.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 ESS64216.1 - 0.14 11.5 0.3 3.1 7.1 0.1 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.7 ESS64216.1 - 0.15 11.7 1.4 0.28 10.8 0.2 1.9 2 0 0 2 2 2 0 NACHT domain Peptidase_S8 PF00082.17 ESS64217.1 - 1.1e-37 129.7 0.0 2e-37 128.8 0.0 1.5 1 0 0 1 1 1 1 Subtilase family CUB PF00431.15 ESS64217.1 - 2.9e-10 40.1 0.0 8.3e-10 38.7 0.0 1.8 2 0 0 2 2 2 1 CUB domain EGF_2 PF07974.8 ESS64217.1 - 0.014 15.5 5.5 0.014 15.5 3.8 6.2 4 1 2 6 6 6 0 EGF-like domain ECR1_N PF14382.1 ESS64217.1 - 0.12 11.7 0.2 7.2 6.0 0.0 3.7 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region Thioredoxin PF00085.15 ESS64218.1 - 1.1e-08 34.6 0.0 2.4e-05 23.9 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 ESS64218.1 - 0.022 14.9 0.0 0.042 14.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESS64218.1 - 0.11 12.6 0.0 7.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like Atg14 PF10186.4 ESS64219.1 - 0.0019 17.2 0.2 0.0029 16.6 0.2 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 ERM PF00769.14 ESS64219.1 - 0.012 15.2 3.1 0.017 14.6 2.2 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3573 PF12097.3 ESS64219.1 - 0.1 11.2 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CENP-Q PF13094.1 ESS64219.1 - 0.17 11.9 3.3 0.32 11.0 2.3 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MORN PF02493.15 ESS64220.1 - 1.5e-48 159.7 95.7 5.3e-06 25.8 0.3 21.2 20 0 0 20 20 20 19 MORN repeat MutS_V PF00488.16 ESS64221.1 - 7.5e-30 104.0 0.2 1.5e-29 103.0 0.0 1.5 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.13 ESS64221.1 - 9.7e-25 87.5 0.1 2.8e-24 86.0 0.0 1.7 2 0 0 2 2 2 1 MutS domain III AAA_29 PF13555.1 ESS64221.1 - 0.0004 19.8 0.0 0.0011 18.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 ESS64221.1 - 0.0011 18.9 0.2 0.005 16.8 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESS64221.1 - 0.0023 18.0 0.0 0.0068 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain MutS_IV PF05190.13 ESS64221.1 - 0.0034 17.5 0.0 0.007 16.5 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.1 ESS64221.1 - 0.0073 16.6 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS64221.1 - 0.01 15.5 0.8 0.076 12.7 0.2 2.6 3 0 0 3 3 3 0 Part of AAA domain SMC_N PF02463.14 ESS64221.1 - 0.026 13.7 0.0 0.057 12.6 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.1 ESS64221.1 - 0.027 14.0 0.0 0.086 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.4 ESS64221.1 - 0.064 12.1 0.0 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.22 ESS64221.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA PF00004.24 ESS64221.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.1 ESS64221.1 - 0.16 11.9 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESS64221.1 - 0.19 10.6 1.1 0.49 9.3 0.7 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Flagellar_rod PF05149.7 ESS64222.1 - 4.6e-111 370.6 32.8 4.6e-111 370.6 22.7 3.1 2 1 1 3 3 3 2 Paraflagellar rod protein PTCB-BRCT PF12738.2 ESS64223.1 - 7.3e-18 64.1 0.1 5.3e-14 51.8 0.0 4.4 5 0 0 5 5 5 2 twin BRCT domain BRCT PF00533.21 ESS64223.1 - 6.3e-16 58.3 0.0 0.00012 22.0 0.0 5.9 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain TPR_11 PF13414.1 ESS64224.1 - 1.9e-20 72.2 7.3 8.8e-18 63.7 0.4 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS64224.1 - 2.2e-13 49.0 1.2 1.8e-06 27.3 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS64224.1 - 8.9e-12 44.0 2.2 1.8e-05 24.1 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS64224.1 - 2.5e-08 34.3 8.2 3.9e-07 30.5 0.0 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS64224.1 - 9.2e-06 25.9 0.2 0.018 15.3 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS64224.1 - 1.7e-05 24.6 0.7 0.22 11.8 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS64224.1 - 4.5e-05 23.7 0.6 0.14 12.8 0.0 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESS64224.1 - 0.0014 17.7 1.2 0.16 11.0 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS64224.1 - 0.0016 18.2 1.7 0.91 9.4 0.6 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS64224.1 - 0.006 16.2 4.3 0.37 10.6 0.1 3.6 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS64224.1 - 0.013 15.4 2.6 0.24 11.3 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.12 ESS64224.1 - 0.014 15.6 4.5 0.031 14.5 0.3 2.8 3 1 1 4 4 3 0 Bacterial transcriptional activator domain RPN7 PF10602.4 ESS64224.1 - 0.1 11.9 0.8 0.51 9.6 0.6 2.0 1 1 0 1 1 1 0 26S proteasome subunit RPN7 TPR_7 PF13176.1 ESS64224.1 - 0.11 12.3 0.5 1.4 8.8 0.0 3.0 2 1 1 3 3 2 0 Tetratricopeptide repeat Folliculin PF11704.3 ESS64225.1 - 6.8e-11 42.0 0.0 1.4e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Bac_surface_Ag PF01103.18 ESS64226.1 - 2e-18 66.9 1.6 3.6e-18 66.1 0.7 1.4 1 1 0 1 1 1 1 Surface antigen PFU PF09070.6 ESS64226.1 - 0.15 12.0 0.9 6.3 6.8 0.0 2.5 3 0 0 3 3 3 0 PFU (PLAA family ubiquitin binding) Pyr_redox_2 PF07992.9 ESS64227.1 - 1.2e-28 100.4 0.2 4.9e-28 98.3 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS64227.1 - 6.6e-22 77.7 0.3 6.8e-19 68.0 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESS64227.1 - 5.6e-19 68.1 0.5 1.2e-18 67.0 0.1 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.1 ESS64227.1 - 3.1e-10 40.4 0.9 7.1e-08 32.7 0.3 3.0 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESS64227.1 - 4.4e-09 35.6 1.4 0.00025 20.0 0.0 3.7 4 0 0 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 ESS64227.1 - 3e-06 26.3 0.1 1.6e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 ESS64227.1 - 8.8e-06 25.6 1.6 0.022 14.7 0.3 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 ESS64227.1 - 1e-05 24.8 2.2 6.5e-05 22.1 0.5 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase 3HCDH_N PF02737.13 ESS64227.1 - 0.00011 21.8 0.2 0.0003 20.5 0.0 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.12 ESS64227.1 - 0.00032 19.8 0.9 0.043 12.9 0.1 2.3 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.17 ESS64227.1 - 0.00034 19.6 1.8 0.36 9.6 0.6 2.7 2 1 0 2 2 2 2 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.14 ESS64227.1 - 0.00045 19.4 0.1 0.0018 17.4 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.9 ESS64227.1 - 0.0005 18.6 8.6 0.0026 16.3 0.5 3.4 3 2 2 5 5 5 2 HI0933-like protein FAD_binding_3 PF01494.14 ESS64227.1 - 0.00055 19.0 0.2 0.11 11.4 0.1 2.9 3 0 0 3 3 3 1 FAD binding domain NAD_binding_7 PF13241.1 ESS64227.1 - 0.0023 18.1 0.0 0.81 9.9 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding ThiF PF00899.16 ESS64227.1 - 0.004 16.9 0.2 0.024 14.4 0.0 2.3 2 0 0 2 2 2 1 ThiF family Lycopene_cycl PF05834.7 ESS64227.1 - 0.0058 15.5 0.5 0.23 10.3 0.3 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 ESS64227.1 - 0.0076 15.1 5.3 0.021 13.6 0.7 3.0 4 0 0 4 4 4 1 FAD binding domain Shikimate_DH PF01488.15 ESS64227.1 - 0.016 15.3 0.1 0.61 10.1 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.16 ESS64227.1 - 0.043 13.3 0.1 0.24 10.9 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PWI PF01480.12 ESS64227.1 - 0.12 12.4 0.1 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 PWI domain NAD_binding_9 PF13454.1 ESS64227.1 - 0.22 11.3 3.3 3.1 7.5 0.0 3.6 4 0 0 4 4 4 0 FAD-NAD(P)-binding Aa_trans PF01490.13 ESS64229.1 - 5.9e-63 212.7 30.2 6.7e-63 212.5 20.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 ESS64229.1 - 3.3e-08 32.4 12.6 3.3e-08 32.4 8.7 2.1 1 1 1 2 2 2 1 Amino acid permease Trp_Tyr_perm PF03222.8 ESS64229.1 - 6.9e-08 31.7 9.4 6.9e-08 31.7 6.5 2.2 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family RyR PF02026.11 ESS64230.1 - 2.1 8.4 5.1 5.5 7.0 0.0 3.1 3 0 0 3 3 3 0 RyR domain DCX PF03607.12 ESS64231.1 - 0.032 13.8 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 Doublecortin Methyltrn_RNA_4 PF09936.4 ESS64231.1 - 0.11 11.9 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase DNA_pol_A PF00476.15 ESS64232.1 - 1.7e-26 92.7 0.0 3.4e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A RNase_T PF00929.19 ESS64232.1 - 3.4e-16 59.9 0.0 1.6e-15 57.7 0.0 2.1 2 0 0 2 2 2 1 Exonuclease SURF1 PF02104.10 ESS64233.1 - 1.5e-24 87.0 0.1 2.8e-24 86.1 0.1 1.4 1 0 0 1 1 1 1 SURF1 family Peptidase_C2 PF00648.16 ESS64236.1 - 1.3e-29 103.2 0.0 3e-29 101.9 0.0 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.17 ESS64236.1 - 2.5e-12 46.6 0.0 1.3e-10 41.1 0.0 3.3 3 1 0 3 3 3 1 Calpain large subunit, domain III Peptidase_M16_C PF05193.16 ESS64236.1 - 0.0058 16.3 0.1 0.013 15.1 0.1 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain MIT PF04212.13 ESS64236.1 - 0.045 13.6 0.2 0.57 10.0 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 ESS64236.1 - 0.37 10.8 1.6 4.1 7.5 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PhyH PF05721.8 ESS64237.1 - 0.049 13.6 0.1 3.5 7.6 0.0 2.4 2 1 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Radical_SAM PF04055.16 ESS64237.1 - 0.13 12.3 0.5 3.2 7.9 0.3 2.4 1 1 0 1 1 1 0 Radical SAM superfamily MutS_III PF05192.13 ESS64237.1 - 0.16 11.7 0.1 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 MutS domain III FTCD_C PF04961.7 ESS64237.1 - 1 8.7 2.7 0.51 9.7 0.3 1.6 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase cNMP_binding PF00027.24 ESS64238.1 - 2e-32 110.8 0.1 9.5e-19 67.0 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_4 PF12799.2 ESS64238.1 - 0.0012 18.3 3.8 0.026 14.1 0.4 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESS64238.1 - 0.01 15.7 0.9 2.3 8.5 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich repeat MOZ_SAS PF01853.13 ESS64239.1 - 3.6e-26 91.5 0.0 3.4e-25 88.3 0.0 2.2 1 1 0 1 1 1 1 MOZ/SAS family TPR_12 PF13424.1 ESS64240.1 - 1.5e-20 72.8 15.9 3.3e-07 30.1 0.0 4.9 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.1 ESS64240.1 - 3e-11 42.8 24.1 0.0013 18.5 1.4 6.1 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESS64240.1 - 1.4e-09 38.3 15.6 0.0081 16.8 0.5 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS64240.1 - 2.2e-09 36.4 9.5 0.057 13.3 0.5 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESS64240.1 - 1.6e-06 27.6 8.4 0.084 12.5 1.9 3.8 4 0 0 4 4 4 3 TPR repeat Apc3 PF12895.2 ESS64240.1 - 9.4e-05 22.4 3.4 0.6 10.2 0.0 3.6 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESS64240.1 - 0.00072 19.0 4.2 0.58 9.8 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS64240.1 - 0.00076 19.9 19.1 0.18 12.5 1.0 4.9 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS64240.1 - 0.0013 19.0 7.6 1.1 9.9 0.4 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS64240.1 - 0.0063 16.8 11.0 0.094 13.0 0.5 5.2 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS64240.1 - 0.029 14.1 11.0 1.7 8.6 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESS64240.1 - 0.082 12.7 0.1 14 5.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc5 PF12862.2 ESS64240.1 - 0.35 10.7 1.9 0.76 9.6 0.0 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 HemY_N PF07219.8 ESS64240.1 - 0.48 9.9 5.5 8.5 5.9 0.1 2.5 2 1 0 2 2 2 0 HemY protein N-terminus Ras PF00071.17 ESS64241.1 - 3.1e-52 176.2 0.0 3.7e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS64241.1 - 9.2e-17 61.6 0.0 1.7e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS64241.1 - 4.9e-11 42.1 0.0 5.7e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.1 ESS64241.1 - 1.3e-06 28.5 0.0 3.2e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESS64241.1 - 4.5e-05 22.7 0.0 7.7e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS64241.1 - 7.2e-05 22.8 0.1 0.00037 20.5 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 ESS64241.1 - 7.3e-05 22.7 0.0 0.00012 22.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.7 ESS64241.1 - 0.0002 21.0 0.0 0.00032 20.4 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Gtr1_RagA PF04670.7 ESS64241.1 - 0.0011 18.1 0.0 0.002 17.3 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.22 ESS64241.1 - 0.0014 18.8 0.0 0.0022 18.2 0.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_5 PF07728.9 ESS64241.1 - 0.0039 16.9 0.0 0.0084 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) SRPRB PF09439.5 ESS64241.1 - 0.0042 16.3 0.0 0.0098 15.1 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 ESS64241.1 - 0.0044 16.6 0.0 0.0075 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESS64241.1 - 0.0046 17.2 0.0 0.0078 16.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.13 ESS64241.1 - 0.0094 15.2 0.0 3 7.1 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B PduV-EutP PF10662.4 ESS64241.1 - 0.013 14.9 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 ESS64241.1 - 0.016 14.7 0.1 0.031 13.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.1 ESS64241.1 - 0.018 15.0 0.0 0.062 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESS64241.1 - 0.025 14.7 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.8 ESS64241.1 - 0.03 13.2 0.1 0.069 12.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) KAP_NTPase PF07693.9 ESS64241.1 - 0.041 12.8 0.0 0.055 12.4 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA PF00004.24 ESS64241.1 - 0.064 13.4 0.0 0.26 11.4 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.15 ESS64241.1 - 0.089 11.4 0.2 5 5.7 0.1 2.3 2 1 1 3 3 3 0 G-protein alpha subunit AAA_17 PF13207.1 ESS64241.1 - 0.09 13.5 0.0 0.15 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESS64241.1 - 0.095 12.1 0.0 0.15 11.5 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain PRK PF00485.13 ESS64241.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 ESS64241.1 - 0.11 12.3 0.1 0.24 11.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESS64241.1 - 0.12 11.8 0.3 0.44 9.9 0.2 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESS64241.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.1 ESS64241.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain SKG6 PF08693.5 ESS64242.1 - 9.3 5.6 14.2 0.1 11.9 1.8 3.3 3 0 0 3 3 3 0 Transmembrane alpha-helix domain zf-RING_5 PF14634.1 ESS64244.1 - 9.7e-05 22.0 15.9 0.00017 21.2 11.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain IncA PF04156.9 ESS64244.1 - 0.012 15.2 6.6 0.017 14.7 4.5 1.1 1 0 0 1 1 1 0 IncA protein DUF2400 PF09674.5 ESS64244.1 - 0.024 14.3 2.2 0.034 13.8 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) MRP-S31 PF15433.1 ESS64244.1 - 0.09 12.1 5.2 0.14 11.5 3.6 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 COG6 PF06419.6 ESS64244.1 - 0.14 10.2 7.0 0.17 9.9 4.8 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 PA26 PF04636.8 ESS64244.1 - 0.17 10.5 2.8 0.23 10.1 1.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) zf-C3HC4_2 PF13923.1 ESS64244.1 - 0.18 11.8 16.3 0.39 10.7 11.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) APG6 PF04111.7 ESS64244.1 - 0.19 10.7 8.2 0.28 10.1 5.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF948 PF06103.6 ESS64244.1 - 0.27 11.0 3.1 0.48 10.3 2.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) PolC_DP2 PF03833.8 ESS64244.1 - 0.48 8.0 2.3 0.58 7.7 1.6 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF2229 PF09989.4 ESS64244.1 - 0.59 9.5 2.4 0.88 8.9 1.6 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Prominin PF05478.6 ESS64244.1 - 0.63 7.4 4.8 0.83 7.1 3.3 1.1 1 0 0 1 1 1 0 Prominin zf-C3HC4 PF00097.20 ESS64244.1 - 1.8 8.2 15.5 4 7.1 10.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Atg14 PF10186.4 ESS64244.1 - 2.2 7.1 13.9 3.2 6.5 9.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ERM PF00769.14 ESS64244.1 - 3 7.3 14.3 5.2 6.5 9.9 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Macoilin PF09726.4 ESS64244.1 - 3.9 5.6 14.2 0.86 7.8 6.2 1.9 2 0 0 2 2 2 0 Transmembrane protein DUF4200 PF13863.1 ESS64245.1 - 8.4e-27 93.6 18.4 8.4e-27 93.6 12.8 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4200) WD40 PF00400.27 ESS64246.1 - 0.00011 21.9 6.3 1 9.3 0.4 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat Acetyltransf_1 PF00583.19 ESS64247.1 - 1.1e-14 54.2 0.1 1.9e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 ESS64247.1 - 1.3e-07 31.2 0.0 2.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 ESS64247.1 - 2.4e-05 24.4 1.3 3.5e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESS64247.1 - 0.0013 18.5 0.3 0.0013 18.5 0.2 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESS64247.1 - 0.0021 18.1 0.0 0.0042 17.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Metal_resist PF13801.1 ESS64247.1 - 0.0025 17.8 0.5 0.0025 17.8 0.4 1.7 2 0 0 2 2 2 1 Heavy-metal resistance Acetyltransf_3 PF13302.1 ESS64247.1 - 0.0037 17.4 0.0 0.0061 16.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESS64247.1 - 0.017 15.0 0.4 0.026 14.4 0.2 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESS64247.1 - 0.021 14.6 0.2 0.031 14.1 0.2 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3292 PF11696.3 ESS64247.1 - 0.22 9.3 1.7 0.28 9.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) SDA1 PF05285.7 ESS64248.1 - 0.23 10.6 6.2 0.37 10.0 4.3 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.9 ESS64248.1 - 1.6 6.6 10.4 2.4 6.1 7.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 ESS64248.1 - 2.6 6.4 7.4 4.2 5.7 5.1 1.2 1 0 0 1 1 1 0 Daxx Family DUF2457 PF10446.4 ESS64248.1 - 3.9 6.1 18.8 8.2 5.0 13.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.7 ESS64248.1 - 6.7 4.4 14.5 9.8 3.9 10.0 1.1 1 0 0 1 1 1 0 Nop14-like family Nipped-B_C PF12830.2 ESS64249.1 - 7.9e-46 156.0 0.0 7.9e-46 156.0 0.0 2.6 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus DUF3437 PF11919.3 ESS64249.1 - 0.0099 15.5 0.3 17 5.1 0.0 4.6 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) Adaptin_N PF01602.15 ESS64249.1 - 0.036 12.3 2.4 0.03 12.6 0.2 1.8 2 0 0 2 2 2 0 Adaptin N terminal region DUF2413 PF10310.4 ESS64249.1 - 0.66 8.7 6.2 1.2 7.9 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) AMP-binding PF00501.23 ESS64251.1 - 2.3e-54 184.4 0.2 3.3e-54 183.8 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme FeoA PF04023.9 ESS64251.1 - 0.068 13.1 0.1 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 FeoA domain AMP-binding_C PF13193.1 ESS64251.1 - 0.088 13.7 0.0 0.28 12.1 0.0 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Glyco_hydro_75 PF07335.6 ESS64251.1 - 0.15 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 Radial_spoke PF04712.7 ESS64252.1 - 5e-156 520.2 16.5 1.4e-154 515.5 10.5 2.2 1 1 0 1 1 1 1 Radial spokehead-like protein Pkinase PF00069.20 ESS64253.1 - 3.5e-77 259.0 0.0 5.9e-77 258.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64253.1 - 5.3e-42 143.6 0.0 9.8e-42 142.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.1 ESS64253.1 - 4.8e-11 42.7 0.1 0.00047 20.3 0.0 3.3 2 1 1 3 3 3 2 HEAT repeats Arm PF00514.18 ESS64253.1 - 1.8e-09 37.0 0.2 0.00028 20.5 0.0 5.2 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT PF02985.17 ESS64253.1 - 4.8e-08 32.4 0.7 0.032 14.3 0.0 5.1 6 0 0 6 6 5 2 HEAT repeat HEAT_EZ PF13513.1 ESS64253.1 - 1.1e-06 28.9 0.2 0.036 14.5 0.0 4.9 2 1 2 4 4 4 1 HEAT-like repeat Kinase-like PF14531.1 ESS64253.1 - 6.1e-06 25.4 0.0 2.4e-05 23.4 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESS64253.1 - 0.0055 15.7 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESS64253.1 - 0.0078 15.5 0.1 0.016 14.5 0.1 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESS64253.1 - 0.0092 15.3 0.9 0.023 14.0 0.6 1.6 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESS64253.1 - 0.013 15.2 0.0 0.11 12.2 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Arm_2 PF04826.8 ESS64253.1 - 0.023 13.8 0.0 0.46 9.5 0.0 2.5 2 0 0 2 2 2 0 Armadillo-like Atrophin-1 PF03154.10 ESS64254.1 - 0.014 13.6 8.5 0.014 13.5 5.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family Tom37_C PF11801.3 ESS64254.1 - 0.031 14.1 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Tom37 C-terminal domain DUF3671 PF12420.3 ESS64254.1 - 0.032 14.1 0.1 0.054 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function Glt_symporter PF03616.9 ESS64254.1 - 0.055 11.9 0.0 0.064 11.7 0.0 1.0 1 0 0 1 1 1 0 Sodium/glutamate symporter TT_ORF1 PF02956.9 ESS64254.1 - 0.17 10.2 1.7 0.18 10.2 1.2 1.0 1 0 0 1 1 1 0 TT viral orf 1 zf-LITAF-like PF10601.4 ESS64254.1 - 1.2 9.0 8.5 2 8.3 5.9 1.3 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain DUF1777 PF08648.7 ESS64254.1 - 1.9 8.2 17.1 2.3 7.9 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF2956 PF11169.3 ESS64254.1 - 4.5 7.2 10.2 7.2 6.6 7.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2956) Cwf_Cwc_15 PF04889.7 ESS64255.1 - 0.039 13.6 1.1 0.066 12.9 0.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TPR_2 PF07719.12 ESS64256.1 - 1.8e-07 30.5 8.3 0.00015 21.3 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS64256.1 - 1.1e-05 24.9 7.3 0.00082 18.9 0.1 3.7 4 0 0 4 4 4 2 TPR repeat TPR_14 PF13428.1 ESS64256.1 - 6.2e-05 23.2 14.3 0.078 13.6 0.1 4.9 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS64256.1 - 0.0012 18.5 1.0 0.13 12.0 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS64256.1 - 0.006 16.2 4.1 3.2 7.7 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS64256.1 - 0.0076 15.8 4.8 0.055 13.0 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS64256.1 - 0.013 15.3 4.1 2.3 8.2 0.2 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS64256.1 - 0.039 14.6 14.8 0.93 10.2 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESS64256.1 - 0.047 13.8 0.9 3.6 7.7 0.1 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.9 ESS64256.1 - 0.068 13.6 1.0 0.57 10.7 0.7 2.7 1 0 0 1 1 1 0 Tetratricopeptide repeat NARP1 PF12569.3 ESS64256.1 - 0.08 11.6 1.0 0.13 11.0 0.1 1.7 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.1 ESS64256.1 - 0.16 12.4 3.1 1.3 9.6 0.0 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS64256.1 - 4.6 7.1 14.4 22 5.0 0.3 5.0 4 1 0 5 5 5 0 Tetratricopeptide repeat Lectin_C PF00059.16 ESS64259.1 - 1.1e-08 35.6 0.1 0.082 13.5 0.0 4.0 3 1 0 3 3 3 3 Lectin C-type domain Peptidase_C2 PF00648.16 ESS64261.1 - 3.3e-49 167.4 0.0 5.1e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS64261.1 - 1.2e-35 121.6 0.0 2.9e-35 120.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Pyrophosphatase PF00719.14 ESS64261.1 - 0.037 13.4 0.0 3.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Inorganic pyrophosphatase KRTDAP PF15200.1 ESS64261.1 - 0.094 12.4 0.0 0.79 9.5 0.0 2.4 2 0 0 2 2 2 0 Keratinocyte differentiation-associated Lyase_1 PF00206.15 ESS64262.1 - 7.4e-52 176.4 0.0 9.7e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.6 ESS64262.1 - 3.6e-44 149.2 0.0 8e-44 148.1 0.0 1.6 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal DUF4111 PF13427.1 ESS64262.1 - 0.092 12.5 0.0 0.59 9.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4111) N_Asn_amidohyd PF14736.1 ESS64263.1 - 0.16 10.8 0.0 1.4 7.7 0.0 2.3 3 0 0 3 3 3 0 Protein N-terminal asparagine amidohydrolase DUF2423 PF10338.4 ESS64264.1 - 0.00044 20.1 7.3 0.00044 20.1 5.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DUF1713 PF08213.6 ESS64264.1 - 1.2 8.8 8.0 0.52 9.9 1.8 2.5 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1713) NTP_transf_2 PF01909.18 ESS64265.1 - 3.3e-05 24.1 0.0 7.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.14 ESS64265.1 - 0.001 18.9 0.4 0.0025 17.7 0.3 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase zf-DHHC PF01529.15 ESS64266.1 - 4.9e-21 74.8 1.7 1.1e-20 73.8 0.2 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.25 ESS64266.1 - 1.6e-06 27.6 0.3 7.6e-05 22.3 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 ESS64266.1 - 2.2e-05 24.8 0.0 0.01 16.3 0.0 3.3 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESS64266.1 - 4.7e-05 23.6 0.0 0.00039 20.6 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS64266.1 - 0.00012 22.1 0.0 0.00096 19.3 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS64266.1 - 0.00059 19.8 0.0 0.094 13.0 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeat Rop-like PF05082.8 ESS64266.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Rop-like TBCC PF07986.7 ESS64268.1 - 1e-32 112.0 1.3 1.6e-32 111.4 0.9 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C EF-hand_6 PF13405.1 ESS64269.1 - 1e-08 34.3 2.3 0.013 15.3 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 ESS64269.1 - 1.5e-06 28.2 2.6 0.0041 17.2 1.9 3.2 1 1 0 1 1 1 1 EF-hand domain pair zf-C3HC4_2 PF13923.1 ESS64269.1 - 1.9e-06 27.8 9.6 1.9e-06 27.8 6.7 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) EF-hand_1 PF00036.27 ESS64269.1 - 3.4e-06 25.9 0.1 0.25 10.7 0.0 3.6 3 0 0 3 3 3 2 EF hand zf-RING_2 PF13639.1 ESS64269.1 - 1.6e-05 24.6 10.5 5.2e-05 22.9 7.3 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESS64269.1 - 3.4e-05 23.3 6.4 3.4e-05 23.3 4.4 2.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS64269.1 - 0.00015 21.5 8.8 0.00015 21.5 6.1 2.9 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 ESS64269.1 - 0.004 16.9 8.7 0.004 16.9 6.0 2.5 2 1 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 ESS64269.1 - 0.0081 15.8 3.2 0.018 14.7 1.9 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESS64269.1 - 0.013 15.1 10.2 0.013 15.1 7.1 2.9 1 1 1 2 2 2 0 zinc-RING finger domain EF-hand_8 PF13833.1 ESS64269.1 - 0.016 14.8 0.6 3.6 7.2 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain pair TPR_11 PF13414.1 ESS64270.1 - 1.7e-44 149.2 32.4 5.7e-10 38.7 1.1 13.4 10 4 5 16 16 15 10 TPR repeat TPR_19 PF14559.1 ESS64270.1 - 2e-43 146.5 35.6 1.1e-07 32.1 0.0 16.3 12 2 5 17 17 17 7 Tetratricopeptide repeat TPR_14 PF13428.1 ESS64270.1 - 2.7e-37 123.8 47.4 0.00015 22.1 0.3 22.0 14 7 9 23 23 23 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESS64270.1 - 8.9e-33 112.2 48.4 9.4e-07 29.3 0.3 14.9 13 3 2 16 16 16 7 Tetratricopeptide repeat TPR_12 PF13424.1 ESS64270.1 - 5e-27 93.6 41.5 4.8e-07 29.6 0.2 15.2 12 4 4 16 16 15 8 Tetratricopeptide repeat TPR_2 PF07719.12 ESS64270.1 - 7.3e-27 91.0 46.3 0.00012 21.7 0.3 19.4 21 0 0 21 21 19 7 Tetratricopeptide repeat TPR_1 PF00515.23 ESS64270.1 - 5.9e-24 82.6 24.8 4.7e-06 25.9 0.3 14.7 16 0 0 16 16 14 4 Tetratricopeptide repeat Apc3 PF12895.2 ESS64270.1 - 2e-22 79.0 26.9 0.0018 18.3 0.2 11.2 8 2 3 12 12 12 7 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESS64270.1 - 8.9e-22 75.1 19.8 0.0034 17.0 0.2 16.3 17 1 1 18 18 15 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS64270.1 - 1.7e-17 61.7 27.3 0.00069 19.2 0.1 14.0 15 0 0 15 15 15 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESS64270.1 - 1.1e-12 47.0 19.7 1.5 9.2 0.0 13.9 17 0 0 17 17 14 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS64270.1 - 5.8e-12 45.2 40.4 0.09 13.2 0.2 17.0 20 0 0 20 20 16 3 Tetratricopeptide repeat RPN7 PF10602.4 ESS64270.1 - 4.6e-07 29.3 9.7 0.0062 15.9 0.1 6.9 6 1 0 6 6 6 1 26S proteasome subunit RPN7 NARP1 PF12569.3 ESS64270.1 - 1.4e-06 27.3 12.9 0.00064 18.6 0.0 6.0 5 2 1 7 7 7 1 NMDA receptor-regulated protein 1 TPR_4 PF07721.9 ESS64270.1 - 0.0017 18.6 32.7 20 5.9 0.2 11.6 11 0 0 11 11 10 0 Tetratricopeptide repeat SNAP PF14938.1 ESS64270.1 - 0.021 13.9 24.9 0.8 8.7 0.8 7.3 6 2 1 7 7 7 0 Soluble NSF attachment protein, SNAP TPR_9 PF13371.1 ESS64270.1 - 0.039 13.7 24.4 0.092 12.6 0.4 8.6 7 2 2 9 9 9 0 Tetratricopeptide repeat Apc5 PF12862.2 ESS64270.1 - 0.16 11.8 9.3 4.6 7.1 0.9 5.8 5 1 2 7 7 5 0 Anaphase-promoting complex subunit 5 TPR_10 PF13374.1 ESS64270.1 - 0.37 10.7 39.5 0.79 9.7 0.2 10.3 10 0 0 10 10 9 0 Tetratricopeptide repeat MIT PF04212.13 ESS64270.1 - 8.8 6.2 18.0 14 5.6 0.1 6.0 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain Y_phosphatase2 PF03162.8 ESS64271.1 - 2.4e-53 179.9 0.0 3.2e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESS64271.1 - 7.4e-09 36.0 0.5 2.9e-08 34.1 0.0 2.0 2 1 1 3 3 3 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESS64271.1 - 0.00081 18.7 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 ESS64271.1 - 0.015 14.8 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESS64271.1 - 0.071 13.1 0.6 0.098 12.7 0.0 1.5 2 0 0 2 2 2 0 Inositol hexakisphosphate Myotub-related PF06602.9 ESS64271.1 - 0.11 11.2 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DENN PF02141.16 ESS64274.1 - 1.3e-12 47.7 0.6 2.3e-12 46.9 0.4 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain Mito_carr PF00153.22 ESS64277.1 - 4.1e-20 71.2 8.2 3.1e-11 42.8 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2938 PF11158.3 ESS64277.1 - 0.0025 17.1 0.1 0.005 16.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2938) DUF4255 PF14065.1 ESS64282.1 - 0.031 13.7 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4255) BT1 PF03092.11 ESS64283.1 - 1.5e-76 257.8 2.7 1.7e-76 257.7 1.9 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 ESS64283.1 - 1.2e-05 24.2 8.3 0.0065 15.2 0.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Thia_YuaJ PF09515.5 ESS64283.1 - 0.00063 19.5 5.8 0.00085 19.1 4.0 1.1 1 0 0 1 1 1 1 Thiamine transporter protein (Thia_YuaJ) Wzy_C PF04932.10 ESS64283.1 - 0.11 12.2 1.0 0.14 11.9 0.7 1.3 1 0 0 1 1 1 0 O-Antigen ligase Na_Ca_ex PF01699.19 ESS64283.1 - 0.68 9.5 6.5 0.13 11.8 1.0 2.2 2 1 0 2 2 2 0 Sodium/calcium exchanger protein BT1 PF03092.11 ESS64284.1 - 4.7e-06 25.5 0.0 5.1e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 BT1 family Polysacc_synt_3 PF13440.1 ESS64284.1 - 0.026 14.0 3.6 0.03 13.7 2.5 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein EI24 PF07264.6 ESS64284.1 - 0.052 12.9 3.5 0.071 12.5 2.4 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF4173 PF13777.1 ESS64284.1 - 0.075 12.3 5.3 0.094 11.9 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) YibE_F PF07907.6 ESS64284.1 - 0.19 10.9 3.9 0.23 10.6 2.7 1.1 1 0 0 1 1 1 0 YibE/F-like protein FA_desaturase PF00487.19 ESS64284.1 - 0.22 10.9 2.1 0.3 10.4 1.5 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DUF4191 PF13829.1 ESS64284.1 - 0.45 9.5 1.8 0.62 9.1 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Sec23_trunk PF04811.10 ESS64286.1 - 3.4e-45 154.3 0.0 5.1e-22 78.4 0.0 2.3 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 ESS64286.1 - 1.2e-25 88.9 0.0 2.4e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESS64286.1 - 3.1e-21 75.6 2.2 5.1e-21 75.0 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 ESS64286.1 - 6e-07 29.0 0.0 1.3e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.10 ESS64286.1 - 1.6e-05 24.3 8.1 5.8e-05 22.5 5.6 2.0 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger OrfB_Zn_ribbon PF07282.6 ESS64286.1 - 0.058 13.0 0.7 0.16 11.6 0.5 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Iso_dh PF00180.15 ESS64289.1 - 5.6e-69 232.7 0.0 6.4e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Thi4 PF01946.12 ESS64290.1 - 0.0067 15.5 0.4 0.013 14.5 0.3 1.4 1 0 0 1 1 1 1 Thi4 family DUF3571 PF12095.3 ESS64290.1 - 0.7 10.1 4.4 3.1 8.0 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3571) RNase_T PF00929.19 ESS64291.1 - 1.7e-22 80.4 0.1 2.5e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Exonuclease A2M_comp PF07678.9 ESS64291.1 - 0.042 13.0 0.0 0.08 12.1 0.0 1.4 1 0 0 1 1 1 0 A-macroglobulin complement component Pterin_4a PF01329.14 ESS64293.1 - 2.5e-09 36.7 0.0 4.1e-08 32.8 0.0 2.2 1 1 1 2 2 2 1 Pterin 4 alpha carbinolamine dehydratase HrpB_C PF08482.5 ESS64293.1 - 0.019 15.1 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent helicase C-terminal Nop PF01798.13 ESS64295.1 - 3.2e-57 192.0 0.2 6.8e-57 190.9 0.1 1.6 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 ESS64295.1 - 1.1e-21 76.4 0.0 2.3e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 ESS64295.1 - 1.6e-18 66.6 0.0 4.1e-18 65.2 0.0 1.8 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Pkinase PF00069.20 ESS64296.1 - 4.4e-59 199.7 0.0 5.6e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64296.1 - 1.5e-28 99.5 0.0 2.6e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESS64296.1 - 1.1e-05 24.5 0.6 2.2e-05 23.6 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS64296.1 - 0.00011 22.0 0.7 0.00011 22.0 0.5 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family CheR PF01739.13 ESS64296.1 - 0.0036 16.6 0.0 0.017 14.4 0.0 1.9 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain RIO1 PF01163.17 ESS64296.1 - 0.066 12.5 0.4 0.13 11.6 0.3 1.5 1 0 0 1 1 1 0 RIO1 family LRR_8 PF13855.1 ESS64298.1 - 1.6e-18 66.1 21.7 6.3e-10 38.6 3.6 3.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 ESS64298.1 - 3.5e-18 64.7 22.2 2e-08 33.6 2.3 3.4 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS64298.1 - 2.1e-11 42.2 14.9 0.0014 18.3 0.1 6.2 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 ESS64298.1 - 1.2e-07 30.7 21.4 0.021 14.9 0.4 5.8 6 0 0 6 6 6 4 Leucine rich repeat LRR_6 PF13516.1 ESS64298.1 - 2.5e-05 23.8 12.8 3 8.2 0.1 5.4 6 0 0 6 6 6 4 Leucine Rich repeat GDA1_CD39 PF01150.12 ESS64299.1 - 1.6e-22 79.6 0.0 2.1e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family BioW PF03744.8 ESS64299.1 - 0.11 11.9 0.1 1 8.7 0.0 2.0 2 0 0 2 2 2 0 6-carboxyhexanoate--CoA ligase ART PF01129.13 ESS64299.1 - 0.11 11.5 0.1 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase GDA1_CD39 PF01150.12 ESS64300.1 - 1e-06 27.5 0.0 1.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Prefoldin_3 PF13758.1 ESS64301.1 - 0.52 10.1 10.6 0.13 12.0 0.8 3.2 3 0 0 3 3 3 0 Prefoldin subunit DEAD PF00270.24 ESS64303.1 - 2.9e-41 140.7 0.0 1.1e-38 132.3 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS64303.1 - 6.5e-26 90.0 0.0 2.3e-25 88.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS64303.1 - 1e-05 25.4 0.0 0.00021 21.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 ESS64303.1 - 0.057 13.3 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Helicase C-terminal domain AAA_13 PF13166.1 ESS64304.1 - 0.015 13.8 0.1 0.025 13.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 ESS64304.1 - 0.028 14.0 2.0 0.075 12.6 1.4 1.7 1 0 0 1 1 1 0 IncA protein WASH_WAHD PF11945.3 ESS64304.1 - 0.033 13.4 1.6 0.13 11.4 0.0 2.3 3 0 0 3 3 3 0 WAHD domain of WASH complex DUF2730 PF10805.3 ESS64304.1 - 0.085 12.5 4.3 1.7 8.4 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF948 PF06103.6 ESS64304.1 - 0.14 12.0 0.1 3 7.7 0.0 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF342 PF03961.8 ESS64304.1 - 0.19 10.1 1.3 0.42 8.9 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) CorA PF01544.13 ESS64304.1 - 0.21 10.5 2.3 0.37 9.7 1.6 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Fmp27_WPPW PF10359.4 ESS64304.1 - 0.83 7.9 3.8 0.25 9.7 0.4 1.7 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DivIC PF04977.10 ESS64304.1 - 0.85 9.1 6.8 27 4.3 0.2 3.5 2 1 1 3 3 3 0 Septum formation initiator FlxA PF14282.1 ESS64304.1 - 4.3 7.3 9.0 0.82 9.6 0.6 3.0 1 1 3 4 4 4 0 FlxA-like protein DUF485 PF04341.7 ESS64305.1 - 0.52 10.0 9.6 0.5 10.1 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 PSP1 PF04468.7 ESS64306.1 - 1.3e-23 82.7 0.6 2.4e-23 81.8 0.4 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region PAM2 PF07145.10 ESS64306.1 - 3 7.5 5.5 6.6 6.4 3.8 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region WD40 PF00400.27 ESS64307.1 - 6.7e-60 196.9 29.3 7.7e-13 47.7 0.9 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESS64307.1 - 0.0058 16.0 0.0 0.41 10.1 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Myosin_head PF00063.16 ESS64308.1 - 3.9e-164 547.4 0.0 5.5e-164 546.9 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 ESS64308.1 - 0.024 14.7 0.0 0.072 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESS64308.1 - 0.12 12.5 0.0 0.35 11.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase PLAC8 PF04749.12 ESS64309.1 - 1.2 9.7 31.2 1.7 9.2 20.0 1.9 2 0 0 2 2 2 0 PLAC8 family Claudin_2 PF13903.1 ESS64309.1 - 9.3 5.9 7.8 25 4.5 1.8 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Thymidylate_kin PF02223.12 ESS64310.1 - 1.6e-16 60.2 0.0 3.5e-16 59.1 0.0 1.5 1 1 0 1 1 1 1 Thymidylate kinase T2SE PF00437.15 ESS64310.1 - 0.0026 16.7 0.1 0.028 13.3 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein PPK2 PF03976.9 ESS64310.1 - 0.0093 15.2 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 1 Polyphosphate kinase 2 (PPK2) Tsg PF04668.7 ESS64310.1 - 0.027 14.6 2.7 0.067 13.3 1.9 1.6 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region Torsin PF06309.6 ESS64310.1 - 0.041 13.7 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Torsin ArgK PF03308.11 ESS64310.1 - 0.068 11.9 0.0 0.13 10.9 0.0 1.4 1 0 0 1 1 1 0 ArgK protein MMS19_N PF14500.1 ESS64311.1 - 6.5e-22 78.0 0.3 6.5e-22 78.0 0.2 2.5 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.1 ESS64311.1 - 0.00086 19.5 0.9 0.093 13.0 0.1 4.0 3 0 0 3 3 3 1 HEAT repeats DUF1981 PF09324.5 ESS64311.1 - 0.0067 15.9 0.0 0.03 13.8 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1981) Gryzun PF07919.7 ESS64312.1 - 8.2e-62 209.2 0.0 1.1e-61 208.8 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Gryzun-like PF12742.2 ESS64312.1 - 0.011 15.4 0.0 0.045 13.5 0.0 2.1 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking TPR_2 PF07719.12 ESS64312.1 - 0.7 9.9 1.8 15 5.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PHD PF00628.24 ESS64313.1 - 7.8e-06 25.4 2.1 1.3e-05 24.7 1.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 ESS64313.1 - 0.056 12.7 1.1 0.086 12.1 0.7 1.3 1 0 0 1 1 1 0 PHD-finger DUF2802 PF10975.3 ESS64313.1 - 0.46 10.2 3.6 0.64 9.8 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) zf-RING-like PF08746.6 ESS64313.1 - 0.68 9.9 3.4 1.4 8.9 2.4 1.6 1 0 0 1 1 1 0 RING-like domain WD40 PF00400.27 ESS64314.1 - 3.2e-08 33.1 9.6 0.003 17.3 0.1 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat LisH PF08513.6 ESS64314.1 - 0.0011 18.6 3.8 0.026 14.3 0.6 2.4 2 0 0 2 2 2 2 LisH DUF4471 PF14740.1 ESS64315.1 - 1.4e-94 316.5 0.8 1.7e-94 316.2 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) TMF_TATA_bd PF12325.3 ESS64315.1 - 0.0087 15.7 1.4 0.017 14.8 0.9 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding HCMVantigenic_N PF12154.3 ESS64315.1 - 0.014 15.2 1.3 0.031 14.1 0.9 1.5 1 0 0 1 1 1 0 Glycoprotein B N-terminal antigenic domain of HCMV Peptidase_M76 PF09768.4 ESS64315.1 - 0.1 12.0 0.3 16 4.8 0.0 2.5 2 0 0 2 2 2 0 Peptidase M76 family DUF2857 PF11198.3 ESS64316.1 - 0.095 12.2 4.1 0.071 12.6 0.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2857) YbjQ_1 PF01906.12 ESS64317.1 - 0.53 10.7 3.5 6.2 7.2 0.2 2.8 1 1 0 2 2 2 0 Putative heavy-metal-binding MRP-S28 PF10213.4 ESS64320.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit protein E1-E2_ATPase PF00122.15 ESS64321.1 - 5.7e-44 149.8 1.6 1.6e-43 148.4 1.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESS64321.1 - 7.4e-35 121.2 0.4 2.2e-34 119.7 0.3 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS64321.1 - 1e-17 64.9 0.0 3.2e-17 63.3 0.0 2.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESS64321.1 - 2.9e-05 23.7 0.1 7.1e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UBA PF00627.26 ESS64324.1 - 2.1e-12 46.4 1.7 1.2e-11 44.1 0.2 2.7 2 0 0 2 2 2 1 UBA/TS-N domain ubiquitin PF00240.18 ESS64324.1 - 0.0066 15.8 0.0 0.015 14.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family NAD_binding_1 PF00175.16 ESS64325.1 - 3.3e-23 82.3 0.0 5.5e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESS64325.1 - 3.7e-13 49.4 0.0 6e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESS64325.1 - 3.3e-06 27.0 0.0 1.2e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain DUF607 PF04678.8 ESS64326.1 - 5.6e-47 159.9 0.0 7.6e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF607 MatE PF01554.13 ESS64327.1 - 5.3e-32 110.6 33.7 1.1e-20 73.8 6.4 2.6 3 0 0 3 3 3 2 MatE zf-C2HC_2 PF13913.1 ESS64328.1 - 2.8e-12 45.9 21.7 1.8e-08 33.8 3.1 3.4 3 0 0 3 3 3 2 zinc-finger of a C2HC-type DUF329 PF03884.9 ESS64328.1 - 0.0017 17.8 4.5 0.006 16.1 0.9 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF329) zf-C2H2 PF00096.21 ESS64328.1 - 0.0083 16.4 9.7 4.8 7.7 2.1 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zinc_ribbon_2 PF13240.1 ESS64328.1 - 0.024 14.1 0.8 2.2 7.8 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESS64328.1 - 0.039 13.1 4.5 1.1 8.5 0.3 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_3 PF14369.1 ESS64328.1 - 0.061 13.3 2.9 7 6.7 0.1 2.7 2 0 0 2 2 2 0 zinc-finger Zn-ribbon_8 PF09723.5 ESS64328.1 - 0.068 13.1 3.7 7.4 6.6 0.0 3.0 3 0 0 3 3 3 0 Zinc ribbon domain FYDLN_acid PF09538.5 ESS64328.1 - 0.18 12.3 5.6 1.3 9.6 1.2 3.1 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) DZR PF12773.2 ESS64328.1 - 0.44 10.3 6.1 9 6.2 0.1 3.3 3 0 0 3 3 3 0 Double zinc ribbon zf-Di19 PF05605.7 ESS64328.1 - 1.9 8.6 4.8 6.6 6.9 0.7 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-HYPF PF07503.7 ESS64328.1 - 2.8 7.4 6.2 36 3.8 0.1 3.3 3 0 0 3 3 3 0 HypF finger Beta_helix PF13229.1 ESS64329.1 - 7e-52 175.3 63.0 1.1e-19 70.7 13.7 6.2 2 2 4 6 6 6 6 Right handed beta helix region NosD PF05048.8 ESS64329.1 - 5.1e-37 127.2 34.4 7.5e-12 44.9 3.2 6.0 3 1 3 6 6 6 6 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.2 ESS64329.1 - 0.58 10.2 39.8 0.019 15.0 6.3 4.9 2 2 3 5 5 5 0 Pectate lyase superfamily protein Beta_helix PF13229.1 ESS64330.1 - 1e-41 142.3 45.8 8.4e-09 35.3 9.6 11.3 6 2 3 10 10 10 7 Right handed beta helix region NosD PF05048.8 ESS64330.1 - 1.2e-27 96.6 30.5 1.1e-07 31.2 2.2 9.5 7 4 2 10 10 10 6 Periplasmic copper-binding protein (NosD) Aegerolysin PF06355.8 ESS64333.1 - 0.045 13.6 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Aegerolysin WD40 PF00400.27 ESS64334.1 - 0.00019 21.2 11.7 0.00081 19.1 0.1 6.1 8 0 0 8 8 8 2 WD domain, G-beta repeat WD40 PF00400.27 ESS64335.1 - 0.0032 17.3 1.9 0.013 15.4 0.0 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF1126 PF06565.7 ESS64336.1 - 1.9e-40 135.9 0.2 2.5e-14 52.4 0.0 3.7 3 0 0 3 3 3 3 Repeat of unknown function (DUF1126) EF-hand_7 PF13499.1 ESS64336.1 - 1.1e-07 31.8 0.2 3.3e-06 27.1 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS64336.1 - 1.6e-06 27.6 2.8 4.5e-05 22.9 0.1 3.8 4 1 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.27 ESS64336.1 - 0.0014 17.7 0.1 0.034 13.4 0.0 3.4 3 0 0 3 3 3 1 EF hand DUF4319 PF14203.1 ESS64336.1 - 0.005 16.3 1.0 0.028 13.9 0.7 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4319) DUF1456 PF07308.8 ESS64336.1 - 0.087 12.8 0.2 2.4 8.2 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) Transket_pyr PF02779.19 ESS64338.1 - 4.5e-55 185.8 0.0 6.9e-55 185.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESS64338.1 - 5.2e-53 179.7 0.0 8e-53 179.1 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component CheR_N PF03705.10 ESS64338.1 - 0.11 11.8 0.0 0.29 10.5 0.0 1.6 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain PIP5K PF01504.13 ESS64339.1 - 6.1e-55 186.0 0.2 1.1e-54 185.2 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase FYVE PF01363.16 ESS64339.1 - 6.8e-15 54.7 6.5 6.8e-15 54.7 4.5 2.6 2 0 0 2 2 2 1 FYVE zinc finger Cpn60_TCP1 PF00118.19 ESS64339.1 - 4.9e-14 51.8 0.0 8.6e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family IBR PF01485.16 ESS64339.1 - 0.016 15.0 4.9 0.046 13.6 2.2 2.7 2 0 0 2 2 2 0 IBR domain HypA PF01155.14 ESS64339.1 - 0.46 10.1 4.3 1.8 8.2 1.8 2.6 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Dabb PF07876.7 ESS64340.1 - 1.7e-09 38.0 0.3 2.1e-09 37.7 0.2 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain ABM PF03992.11 ESS64340.1 - 0.011 15.7 0.1 0.014 15.3 0.1 1.2 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase Dabb PF07876.7 ESS64341.1 - 3e-12 46.8 0.0 3.9e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Oxidored_q6 PF01058.17 ESS64342.1 - 4.9e-19 68.2 0.1 6.7e-19 67.7 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit RdRP_4 PF02123.11 ESS64343.1 - 0.0037 16.0 2.0 0.0046 15.7 1.4 1.1 1 0 0 1 1 1 1 Viral RNA-directed RNA-polymerase DUF3584 PF12128.3 ESS64343.1 - 0.0099 13.2 16.7 0.015 12.6 11.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) ATG16 PF08614.6 ESS64343.1 - 0.035 13.9 22.5 0.46 10.2 15.6 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) HlyD PF00529.15 ESS64343.1 - 0.17 11.1 20.9 0.26 10.5 14.5 1.3 1 0 0 1 1 1 0 HlyD family secretion protein DUF1178 PF06676.6 ESS64343.1 - 8.5 6.5 9.3 1.4 9.1 3.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1178) Peptidase_S46 PF10459.4 ESS64343.1 - 9.7 4.4 13.2 14 3.9 9.2 1.2 1 0 0 1 1 1 0 Peptidase S46 EF-hand_6 PF13405.1 ESS64345.1 - 0.00087 18.9 0.6 0.0092 15.7 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESS64345.1 - 0.0016 17.6 0.7 0.011 14.9 0.3 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 ESS64345.1 - 0.0021 17.6 0.1 0.01 15.4 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 ESS64345.1 - 0.0021 18.1 0.1 0.041 14.0 0.0 2.5 1 1 0 1 1 1 1 EF-hand domain pair Ins145_P3_rec PF08709.6 ESS64345.1 - 0.056 12.4 0.1 1.5 7.7 0.0 2.7 2 1 1 3 3 3 0 Inositol 1,4,5-trisphosphate/ryanodine receptor ArfGap PF01412.13 ESS64347.1 - 2.1e-25 88.7 0.1 3.2e-25 88.1 0.1 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf C1_4 PF07975.7 ESS64347.1 - 0.043 13.8 0.6 0.13 12.2 0.1 2.0 2 0 0 2 2 2 0 TFIIH C1-like domain His_Phos_2 PF00328.17 ESS64348.1 - 2.4e-08 33.6 0.0 1.7e-05 24.3 0.0 2.1 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) TBCC PF07986.7 ESS64349.1 - 6.9e-25 86.7 2.5 1.8e-24 85.4 1.8 1.7 1 1 0 1 1 1 1 Tubulin binding cofactor C DUF2090 PF09863.4 ESS64349.1 - 0.0042 15.9 0.0 0.0074 15.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2090) CAP_C PF08603.6 ESS64349.1 - 0.033 13.5 0.2 0.049 12.9 0.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal Phage_Gp19 PF09355.5 ESS64349.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 cobW PF02492.14 ESS64350.1 - 3.7e-43 147.0 0.1 4.8e-43 146.6 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 ESS64350.1 - 0.0012 18.5 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_19 PF13245.1 ESS64350.1 - 0.0057 16.3 0.0 0.021 14.5 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain ATP_bind_1 PF03029.12 ESS64350.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.1 ESS64350.1 - 0.027 14.3 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESS64350.1 - 0.037 13.5 0.0 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 ESS64350.1 - 0.047 13.8 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 ESS64350.1 - 0.075 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain CbiA PF01656.18 ESS64350.1 - 0.15 11.4 0.0 0.37 10.1 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 ESS64350.1 - 0.16 11.6 0.1 0.36 10.5 0.0 1.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B zf-CCHC PF00098.18 ESS64351.1 - 1e-29 100.9 51.2 0.00019 21.2 0.5 9.4 9 0 0 9 9 9 9 Zinc knuckle zf-CCHC_2 PF13696.1 ESS64351.1 - 7e-05 22.2 42.0 0.00014 21.2 1.0 7.2 4 2 3 7 7 7 4 Zinc knuckle zf-CCHC_4 PF14392.1 ESS64351.1 - 7.6e-05 22.2 58.5 0.023 14.3 1.2 9.2 9 0 0 9 9 9 6 Zinc knuckle NYN PF01936.13 ESS64351.1 - 0.00056 20.2 0.0 0.0012 19.1 0.0 1.7 1 1 0 1 1 1 1 NYN domain Topoisom_bac PF01131.15 ESS64352.1 - 9.4e-77 258.5 0.0 1.7e-76 257.6 0.0 1.4 2 0 0 2 2 2 1 DNA topoisomerase zf-GRF PF06839.7 ESS64352.1 - 1.7e-08 34.2 1.3 5.8e-08 32.5 0.9 2.0 1 0 0 1 1 1 1 GRF zinc finger zf-C4_Topoisom PF01396.14 ESS64352.1 - 1.8e-05 24.1 0.9 1.8e-05 24.1 0.6 3.2 3 0 0 3 3 3 1 Topoisomerase DNA binding C4 zinc finger Topoisom_bac PF01131.15 ESS64353.1 - 1.9e-15 56.6 0.0 2.6e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 ESS64353.1 - 1.6e-14 53.6 0.0 2.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Toprim domain 14-3-3 PF00244.15 ESS64354.1 - 1e-93 312.7 6.0 1.2e-93 312.5 4.2 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 ESS64354.1 - 0.016 15.1 4.2 0.07 13.0 1.6 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Zw10 PF06248.8 ESS64354.1 - 0.076 11.1 1.1 0.12 10.4 0.8 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 Bacteroid_pep PF14406.1 ESS64354.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 Ribosomally synthesized peptide in Bacteroidetes IncA PF04156.9 ESS64355.1 - 0.0011 18.6 23.0 0.0011 18.6 16.0 4.9 1 1 3 4 4 4 2 IncA protein Matrilin_ccoil PF10393.4 ESS64355.1 - 0.0086 15.4 4.1 0.04 13.2 0.0 4.0 4 0 0 4 4 4 1 Trimeric coiled-coil oligomerisation domain of matrilin Prefoldin PF02996.12 ESS64355.1 - 0.026 14.1 1.2 0.026 14.1 0.8 7.2 4 3 0 7 7 7 0 Prefoldin subunit Pox_I6 PF04595.8 ESS64355.1 - 0.044 12.5 0.3 0.077 11.7 0.2 1.3 1 0 0 1 1 1 0 Poxvirus I6-like family Reo_sigmaC PF04582.7 ESS64355.1 - 0.57 9.2 24.0 0.13 11.4 0.8 4.2 1 1 4 5 5 5 0 Reovirus sigma C capsid protein UCR_hinge PF02320.11 ESS64355.1 - 6.1 6.8 9.1 2.7 7.9 0.1 4.0 4 0 0 4 4 4 0 Ubiquinol-cytochrome C reductase hinge protein Rep_fac_C PF08542.6 ESS64356.1 - 3.9e-15 55.6 0.0 8.8e-15 54.4 0.0 1.6 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESS64356.1 - 4e-05 23.3 0.1 6.3e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.8 ESS64356.1 - 0.0017 17.8 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 ESS64356.1 - 0.0047 15.6 0.0 0.0053 15.4 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein DUF3834 PF12916.2 ESS64356.1 - 0.019 13.9 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) GMC_oxred_N PF00732.14 ESS64357.1 - 6.3e-39 133.8 0.0 8.6e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 ESS64357.1 - 1.6e-12 47.9 0.0 2.6e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 ESS64357.1 - 1.4e-07 30.8 0.5 0.013 14.3 0.0 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESS64357.1 - 0.0059 15.4 1.1 0.092 11.5 0.1 2.4 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.9 ESS64357.1 - 0.015 15.1 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS64357.1 - 0.021 13.6 0.1 0.93 8.2 0.3 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESS64357.1 - 0.061 13.3 2.2 0.17 11.9 0.3 2.6 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 ESS64357.1 - 0.1 11.5 0.1 0.18 10.6 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.1 ESS64357.1 - 0.11 12.5 0.0 18 5.3 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PDR_assoc PF08370.6 ESS64358.1 - 0.067 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated AdoHcyase PF05221.12 ESS64359.1 - 2.2e-141 469.4 0.0 2.5e-141 469.3 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 ESS64359.1 - 2e-87 291.1 1.7 2.9e-87 290.6 1.2 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 ESS64359.1 - 1.1e-10 41.0 0.0 2.2e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESS64359.1 - 1.3e-05 24.6 0.1 2.1e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 ESS64359.1 - 4e-05 23.5 0.3 0.0002 21.3 0.2 2.2 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.1 ESS64359.1 - 0.0023 18.1 0.2 0.0061 16.7 0.2 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.14 ESS64359.1 - 0.012 14.6 0.5 0.076 12.0 0.4 2.0 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ELFV_dehydrog PF00208.16 ESS64359.1 - 0.016 14.8 0.1 0.04 13.4 0.0 1.7 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.15 ESS64359.1 - 0.04 14.0 0.1 0.079 13.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Oxidored_nitro PF00148.14 ESS64359.1 - 0.059 12.0 0.2 0.21 10.1 0.1 1.8 1 1 1 2 2 2 0 Nitrogenase component 1 type Oxidoreductase PALP PF00291.20 ESS64359.1 - 0.065 12.4 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme 3HCDH_N PF02737.13 ESS64359.1 - 0.09 12.4 0.1 0.22 11.1 0.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Zip PF02535.17 ESS64360.1 - 0.004 16.2 0.0 0.0064 15.5 0.0 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Conotoxin PF02950.12 ESS64360.1 - 0.074 13.8 0.8 0.13 13.1 0.0 1.7 2 0 0 2 2 2 0 Conotoxin Na_H_antiporter PF03553.9 ESS64361.1 - 0.15 11.0 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Na+/H+ antiporter family WD40 PF00400.27 ESS64362.1 - 3.3e-23 80.6 0.1 3.7e-05 23.4 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat LRR_6 PF13516.1 ESS64363.1 - 5e-07 29.1 2.7 2 8.7 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.28 ESS64363.1 - 5.5e-05 22.6 1.2 0.71 10.1 0.0 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat DUF2894 PF11445.3 ESS64363.1 - 0.026 14.7 6.4 0.073 13.3 4.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) LRR_8 PF13855.1 ESS64363.1 - 0.053 13.2 2.8 5.6 6.8 0.0 3.9 3 1 1 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 ESS64363.1 - 0.11 12.1 6.0 2.3 7.9 0.0 3.7 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) RRF PF01765.14 ESS64363.1 - 0.26 10.7 1.2 0.47 9.9 0.8 1.3 1 0 0 1 1 1 0 Ribosome recycling factor LRR_7 PF13504.1 ESS64363.1 - 0.49 10.7 3.9 16 6.2 0.0 4.5 5 0 0 5 5 5 0 Leucine rich repeat Snf7 PF03357.16 ESS64364.1 - 6.9e-06 25.5 6.7 6.9e-06 25.5 4.6 2.0 1 1 1 2 2 2 1 Snf7 tRNA-synt_2b PF00587.20 ESS64365.1 - 6.7e-55 185.3 0.1 9.9e-55 184.7 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESS64365.1 - 1e-16 60.6 0.0 1.3e-15 57.0 0.0 2.5 2 0 0 2 2 2 1 Anticodon binding domain Cut12 PF11500.3 ESS64367.1 - 6 6.5 12.2 10 5.7 8.5 1.4 1 0 0 1 1 1 0 Spindle pole body formation-associated protein zf-C3HC4_3 PF13920.1 ESS64368.1 - 7.2e-15 54.3 25.2 5.8e-10 38.6 7.7 4.7 6 0 0 6 6 6 3 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS64368.1 - 0.0001 21.9 25.2 0.0012 18.5 7.3 5.3 6 0 0 6 6 6 3 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESS64368.1 - 0.0011 18.9 29.9 0.0069 16.3 8.8 5.0 5 0 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-C2HC_2 PF13913.1 ESS64368.1 - 0.0031 17.1 1.8 0.0031 17.1 1.2 4.7 5 0 0 5 5 5 1 zinc-finger of a C2HC-type zf-C2H2 PF00096.21 ESS64368.1 - 0.27 11.6 0.2 0.27 11.6 0.2 5.1 6 0 0 6 6 6 0 Zinc finger, C2H2 type Rad50_zn_hook PF04423.9 ESS64368.1 - 1.4 8.4 5.7 10 5.6 0.0 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif GCV_T PF01571.16 ESS64370.1 - 1.1e-60 204.6 0.0 1.3e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 ESS64370.1 - 1.1e-20 73.4 0.2 1.9e-20 72.6 0.1 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain T4SS-DNA_transf PF02534.9 ESS64370.1 - 0.027 13.0 0.0 0.037 12.6 0.0 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer ERM PF00769.14 ESS64371.1 - 0.00012 21.7 1.6 0.00012 21.7 1.1 3.9 3 1 0 3 3 3 1 Ezrin/radixin/moesin family Filament PF00038.16 ESS64371.1 - 0.0007 19.1 29.5 0.0044 16.5 4.8 3.5 2 1 1 3 3 3 2 Intermediate filament protein CH PF00307.26 ESS64371.1 - 0.0015 18.5 0.0 0.0044 17.0 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain ADIP PF11559.3 ESS64371.1 - 0.3 10.9 34.9 0.099 12.5 1.1 5.2 4 1 1 5 5 5 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 ESS64371.1 - 1.3 8.1 5.4 0.37 9.9 0.5 2.3 3 0 0 3 3 3 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.3 ESS64371.1 - 1.5 8.6 39.9 0.021 14.5 3.5 4.8 3 2 2 5 5 5 0 TATA element modulatory factor 1 TATA binding NAC PF01849.13 ESS64372.1 - 1e-19 69.8 0.0 1.5e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 NAC domain Ribosomal_L34e PF01199.13 ESS64373.1 - 3.2e-21 75.3 0.3 3.2e-21 75.3 0.2 2.5 2 1 0 2 2 2 1 Ribosomal protein L34e DUF2175 PF09943.4 ESS64373.1 - 0.094 12.7 2.1 0.15 12.1 1.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Radial_spoke_3 PF06098.6 ESS64373.1 - 0.12 11.3 10.4 0.17 10.8 7.2 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 DUF498 PF04430.9 ESS64374.1 - 1.2e-23 82.7 0.0 2.1e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Clp1 PF06807.9 ESS64375.1 - 6.4e-06 26.0 0.1 1.3e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA_19 PF13245.1 ESS64375.1 - 0.024 14.4 0.3 0.72 9.6 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain FtsK_SpoIIIE PF01580.13 ESS64375.1 - 0.072 12.5 0.1 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESS64375.1 - 0.074 13.1 0.0 0.58 10.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain NUDIX PF00293.23 ESS64379.1 - 2.6e-13 49.8 0.1 3.8e-13 49.2 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain DUF1456 PF07308.8 ESS64379.1 - 0.1 12.6 0.0 4.2 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) potato_inhibit PF00280.13 ESS64379.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Potato inhibitor I family Gp_dh_C PF02800.15 ESS64383.1 - 2.5e-46 157.0 0.0 3.2e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESS64383.1 - 0.12 12.3 0.1 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Gp_dh_C PF02800.15 ESS64384.1 - 5.8e-47 159.0 0.0 8.2e-47 158.5 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain COG7 PF10191.4 ESS64385.1 - 4.7e-13 47.9 0.9 4.7e-13 47.9 0.6 1.4 2 0 0 2 2 2 1 Golgi complex component 7 (COG7) TSA PF03249.8 ESS64385.1 - 0.0002 20.0 2.0 0.00025 19.7 1.4 1.1 1 0 0 1 1 1 1 Type specific antigen Protocadherin PF08374.6 ESS64385.1 - 0.013 15.1 1.2 0.021 14.4 0.8 1.2 1 0 0 1 1 1 0 Protocadherin Pyridoxal_deC PF00282.14 ESS64385.1 - 0.084 11.3 2.4 0.037 12.4 0.3 1.4 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain DUF1484 PF07363.6 ESS64385.1 - 4.2 7.7 11.1 2.3 8.6 2.3 2.9 2 2 2 4 4 4 0 Protein of unknown function (DUF1484) YqzE PF14038.1 ESS64385.1 - 7.5 6.3 9.1 18 5.2 6.3 1.6 1 1 0 1 1 1 0 YqzE-like protein Prenyltrans PF00432.16 ESS64386.1 - 2e-29 100.8 18.7 8.2e-08 31.6 0.1 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESS64386.1 - 8.5e-17 61.5 1.4 6.6e-12 45.8 0.0 3.8 4 1 0 4 4 4 3 Prenyltransferase-like Shadoo PF14999.1 ESS64387.1 - 0.092 12.5 0.9 5.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective AJAP1_PANP_C PF15298.1 ESS64387.1 - 0.21 11.4 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus zf-C2H2_6 PF13912.1 ESS64390.1 - 0.0008 19.2 0.7 0.0021 17.8 0.5 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESS64390.1 - 0.0082 16.4 0.2 0.028 14.7 0.1 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger Muted PF14942.1 ESS64390.1 - 0.017 15.0 8.1 0.04 13.7 5.6 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein zf-C2H2_jaz PF12171.3 ESS64390.1 - 0.062 13.4 0.1 0.18 11.9 0.1 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-LITAF-like PF10601.4 ESS64390.1 - 0.54 10.1 6.3 1.2 9.0 4.4 1.6 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Spc24 PF08286.6 ESS64390.1 - 1.4 8.6 11.8 3.6 7.3 8.2 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 UPF0029 PF01205.14 ESS64391.1 - 0.12 12.1 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein family UPF0029 Cyt-b5 PF00173.23 ESS64392.1 - 1.3e-20 72.9 0.0 2.8e-20 71.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FYVE PF01363.16 ESS64393.1 - 2.2e-24 85.1 26.3 4e-18 65.0 9.7 2.5 2 0 0 2 2 2 2 FYVE zinc finger MORN PF02493.15 ESS64393.1 - 3e-15 54.9 37.5 0.0012 18.4 0.5 9.6 10 0 0 10 10 10 7 MORN repeat FYVE_2 PF02318.11 ESS64393.1 - 0.0036 17.1 21.3 0.052 13.4 1.3 2.7 3 0 0 3 3 3 2 FYVE-type zinc finger MORN PF02493.15 ESS64394.1 - 6.6e-22 75.8 55.7 0.00027 20.4 0.5 12.6 12 1 0 12 12 12 9 MORN repeat MORN PF02493.15 ESS64395.1 - 6.1e-19 66.5 34.0 5.3e-05 22.7 1.1 6.7 7 0 0 7 7 7 6 MORN repeat DnaJ PF00226.26 ESS64396.1 - 4.7e-22 77.5 0.5 7.2e-22 76.9 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain DegS PF05384.6 ESS64396.1 - 0.0058 15.8 1.5 0.016 14.4 1.1 1.7 1 1 0 1 1 1 1 Sensor protein DegS FAM176 PF14851.1 ESS64396.1 - 0.083 12.5 0.1 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 FAM176 family WD40 PF00400.27 ESS64397.1 - 9.5e-26 88.7 19.1 5.9e-06 25.9 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat WWE PF02825.15 ESS64397.1 - 1.3e-08 34.1 0.1 4.7e-08 32.3 0.0 2.0 1 0 0 1 1 1 1 WWE domain Nup160 PF11715.3 ESS64397.1 - 0.0039 15.3 0.2 0.0079 14.3 0.1 1.5 1 1 0 1 1 1 1 Nucleoporin Nup120/160 A2L_zn_ribbon PF08792.5 ESS64398.1 - 0.0078 15.6 2.1 1.4 8.4 0.1 2.5 2 0 0 2 2 2 2 A2L zinc ribbon domain MMR_HSR1 PF01926.18 ESS64400.1 - 1.8e-13 50.4 0.0 3e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS64400.1 - 2.8e-05 23.4 0.0 4.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 ESS64400.1 - 0.00023 20.3 0.5 0.00046 19.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 ESS64400.1 - 0.00067 19.5 1.6 0.0065 16.3 0.2 2.3 1 1 1 2 2 2 1 Dynamin family Miro PF08477.8 ESS64400.1 - 0.034 14.6 0.0 0.069 13.6 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein GTP_EFTU PF00009.22 ESS64400.1 - 0.039 13.3 0.0 0.3 10.5 0.1 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AIG1 PF04548.11 ESS64400.1 - 0.086 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 AIG1 family FUSC_2 PF13515.1 ESS64402.1 - 8e-05 22.5 10.1 8e-05 22.5 7.0 3.5 2 2 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 ESS64402.1 - 0.022 13.4 6.8 0.0057 15.3 1.7 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter Thioredoxin PF00085.15 ESS64404.1 - 0.011 15.4 0.0 0.11 12.1 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin DUF1611 PF07755.6 ESS64404.1 - 0.017 13.7 0.0 0.027 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1611) DAO PF01266.19 ESS64404.1 - 0.16 10.8 0.8 0.68 8.7 0.2 2.0 1 1 1 2 2 2 0 FAD dependent oxidoreductase DNA_ligase_OB_2 PF14743.1 ESS64405.1 - 4.9e-19 67.7 0.1 8.3e-19 67.0 0.1 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.16 ESS64405.1 - 8.6e-19 67.7 0.0 3.5e-18 65.7 0.0 1.9 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DUF4379 PF14311.1 ESS64405.1 - 0.0015 18.3 3.0 0.0038 17.0 2.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) mRNA_cap_enzyme PF01331.14 ESS64405.1 - 0.021 14.5 0.0 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain FlhC PF05280.6 ESS64405.1 - 0.11 12.0 0.6 0.27 10.7 0.4 1.6 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) DNA_ligase_OB_2 PF14743.1 ESS64406.1 - 8.2e-22 76.6 0.3 1.4e-21 75.9 0.2 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.16 ESS64406.1 - 5.7e-18 65.0 0.0 9.2e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DUF4379 PF14311.1 ESS64406.1 - 4.8e-14 51.9 2.7 1e-13 50.8 1.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) Zn_Tnp_IS1595 PF12760.2 ESS64406.1 - 0.013 15.2 2.9 0.26 11.1 0.2 2.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Cys_rich_CPXG PF14255.1 ESS64406.1 - 0.048 13.4 0.9 0.099 12.4 0.6 1.6 1 0 0 1 1 1 0 Cysteine-rich CPXCG Zn-ribbon_8 PF09723.5 ESS64406.1 - 0.15 12.0 1.6 0.22 11.4 0.3 1.9 2 0 0 2 2 2 0 Zinc ribbon domain DUF2387 PF09526.5 ESS64406.1 - 0.34 10.8 2.7 0.56 10.1 0.2 2.3 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) zf-FPG_IleRS PF06827.9 ESS64406.1 - 0.39 10.4 5.4 1.1 8.9 3.7 1.8 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS UPF0547 PF10571.4 ESS64406.1 - 3.1 7.5 10.0 0.25 11.0 1.2 2.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 SnAPC_2_like PF11035.3 ESS64409.1 - 0.053 13.0 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Small nuclear RNA activating complex subunit 2-like Utp12 PF04003.7 ESS64411.1 - 0.0085 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family FAM165 PF14981.1 ESS64411.1 - 0.21 11.1 2.8 0.68 9.4 1.9 1.9 1 0 0 1 1 1 0 FAM165 family Cupin_8 PF13621.1 ESS64412.1 - 6.5e-63 212.5 0.6 2.9e-61 207.1 0.1 2.6 2 1 0 2 2 2 1 Cupin-like domain DUF4131 PF13567.1 ESS64413.1 - 0.013 14.8 0.4 0.015 14.7 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Dsh_C PF12316.3 ESS64414.1 - 0.0097 16.0 2.4 0.012 15.6 1.7 1.1 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal Med19 PF10278.4 ESS64414.1 - 0.16 11.6 29.6 0.22 11.1 20.5 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CAF-1_p150 PF11600.3 ESS64414.1 - 0.45 9.8 34.2 0.53 9.6 23.7 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DDHD PF02862.12 ESS64414.1 - 0.77 9.5 9.6 0.87 9.3 6.7 1.1 1 0 0 1 1 1 0 DDHD domain PBP_sp32 PF07222.7 ESS64414.1 - 0.89 8.6 11.6 1 8.4 8.1 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Zip PF02535.17 ESS64414.1 - 0.93 8.4 5.9 0.91 8.4 4.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter FancD2 PF14631.1 ESS64414.1 - 1.4 5.9 8.5 1.5 5.8 5.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF1510 PF07423.6 ESS64414.1 - 1.9 7.8 18.1 2.3 7.5 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FLO_LFY PF01698.11 ESS64414.1 - 3.7 6.2 13.8 4.3 6.0 9.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein AUX_IAA PF02309.11 ESS64414.1 - 7.5 6.2 14.9 8.7 6.0 10.4 1.0 1 0 0 1 1 1 0 AUX/IAA family DUF3435 PF11917.3 ESS64414.1 - 8.8 4.9 14.9 10 4.6 10.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DnaJ PF00226.26 ESS64416.1 - 1.4e-20 72.7 0.3 2.7e-20 71.8 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESS64416.1 - 0.0039 16.5 0.0 0.0087 15.3 0.0 1.6 1 0 0 1 1 1 1 X-domain of DnaJ-containing Mucin PF01456.12 ESS64417.1 - 1.2e-05 25.1 30.6 0.0087 15.8 21.2 3.4 1 1 0 1 1 1 1 Mucin-like glycoprotein RHSP PF07999.6 ESS64418.1 - 1.6e-36 125.8 0.0 1.8e-36 125.6 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Nitro_FeMo-Co PF02579.12 ESS64418.1 - 0.014 15.4 0.0 0.11 12.6 0.0 2.2 2 1 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor RHSP PF07999.6 ESS64419.1 - 4.9e-42 144.0 0.2 9e-42 143.1 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF641 PF04859.7 ESS64420.1 - 0.34 10.6 7.5 3.4 7.4 0.7 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) zf-C3HC4_2 PF13923.1 ESS64421.1 - 2.4e-09 37.0 8.2 5.6e-09 35.8 5.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS64421.1 - 4.9e-09 35.8 9.1 1e-08 34.8 6.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESS64421.1 - 7.1e-09 35.1 7.7 1.4e-08 34.2 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS64421.1 - 2.2e-08 33.6 7.0 3.9e-08 32.8 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS64421.1 - 4.7e-07 29.4 8.3 1e-06 28.3 5.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESS64421.1 - 3.7e-05 23.5 8.9 8.9e-05 22.2 6.1 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 ESS64421.1 - 0.00037 20.5 3.3 0.00091 19.2 2.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 ESS64421.1 - 0.0097 15.6 9.8 0.01 15.5 5.3 2.3 2 0 0 2 2 2 1 RING-type zinc-finger FYVE PF01363.16 ESS64421.1 - 0.02 14.7 4.6 0.051 13.4 3.2 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-MIZ PF02891.15 ESS64421.1 - 0.066 12.7 9.2 0.2 11.1 6.4 1.8 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Apc11 PF12861.2 ESS64421.1 - 0.071 12.9 2.6 0.14 11.9 1.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PARP PF00644.15 ESS64423.1 - 1.2e-63 214.3 0.0 2e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 ESS64423.1 - 6.3e-43 145.6 0.2 9e-43 145.1 0.2 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 ESS64423.1 - 7.1e-26 89.9 0.8 1.5e-25 88.9 0.5 1.6 1 0 0 1 1 1 1 WGR domain Myosin_TH1 PF06017.8 ESS64424.1 - 9.2e-05 21.8 0.0 0.00015 21.1 0.0 1.2 1 0 0 1 1 1 1 Myosin tail DUF2353 PF09789.4 ESS64424.1 - 0.032 13.5 0.1 0.039 13.2 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) WD40 PF00400.27 ESS64425.1 - 1e-10 41.0 9.4 0.0013 18.5 0.1 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESS64425.1 - 1e-06 27.8 3.4 0.013 14.3 0.0 4.1 4 1 1 5 5 5 2 Coatomer WD associated region TPR_1 PF00515.23 ESS64425.1 - 0.00012 21.5 5.0 0.63 9.7 0.1 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS64425.1 - 0.0033 17.3 9.4 0.31 10.9 0.0 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS64425.1 - 0.0052 16.4 11.8 0.16 11.8 0.2 4.6 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS64425.1 - 0.0073 16.0 2.8 0.14 12.0 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Vps39_1 PF10366.4 ESS64425.1 - 0.022 14.7 0.7 0.07 13.1 0.1 2.2 2 0 0 2 2 1 0 Vacuolar sorting protein 39 domain 1 TPR_11 PF13414.1 ESS64425.1 - 0.032 13.8 7.6 0.3 10.7 0.2 3.9 3 0 0 3 3 3 0 TPR repeat eIF2A PF08662.6 ESS64425.1 - 0.04 13.6 0.1 1.9 8.1 0.0 2.8 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 ESS64425.1 - 0.043 11.6 1.8 0.37 8.5 0.0 2.6 3 0 0 3 3 3 0 IKI3 family RPN7 PF10602.4 ESS64425.1 - 0.044 13.1 1.6 1.1 8.6 0.0 2.8 3 0 0 3 3 3 0 26S proteasome subunit RPN7 Prok-RING_4 PF14447.1 ESS64425.1 - 0.051 13.1 7.3 0.15 11.5 5.1 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TPR_2 PF07719.12 ESS64425.1 - 0.1 12.5 17.3 0.36 10.8 0.1 5.5 6 2 1 7 7 5 0 Tetratricopeptide repeat PPR PF01535.15 ESS64425.1 - 0.1 12.6 0.0 14 5.9 0.0 3.0 2 0 0 2 2 2 0 PPR repeat TPR_14 PF13428.1 ESS64425.1 - 0.14 12.9 13.8 3.9 8.3 0.5 5.2 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS64425.1 - 0.23 11.7 5.3 5.5 7.4 0.5 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-ribbon_3 PF13248.1 ESS64425.1 - 4.8 6.5 8.6 2.2 7.6 0.5 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Slu7 PF11708.3 ESS64426.1 - 1.2e-05 25.2 9.0 0.00017 21.4 0.1 3.0 3 0 0 3 3 3 2 Pre-mRNA splicing Prp18-interacting factor CWC25 PF12542.3 ESS64426.1 - 0.22 12.0 8.2 1.3 9.4 2.4 2.5 2 0 0 2 2 2 0 Pre-mRNA splicing factor PhageMin_Tail PF10145.4 ESS64427.1 - 0.044 13.4 3.3 2.6 7.6 0.1 3.5 2 1 2 4 4 4 0 Phage-related minor tail protein FAST_1 PF06743.10 ESS64427.1 - 0.11 12.2 0.1 4.8 6.9 0.0 3.5 4 1 0 4 4 4 0 FAST kinase-like protein, subdomain 1 plasmid_Toxin PF12703.2 ESS64427.1 - 0.69 9.7 5.1 2.9 7.7 0.1 3.6 4 0 0 4 4 4 0 Toxin of toxin-antitoxin type 1 system TPMT PF05724.6 ESS64428.1 - 2.8e-21 75.9 1.0 2.9e-21 75.9 0.0 1.5 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.2 ESS64428.1 - 5.8e-05 23.6 0.0 0.00011 22.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS64428.1 - 0.032 13.9 0.0 0.063 12.9 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 ESS64428.1 - 0.039 14.4 0.0 0.086 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Sec3_C PF09763.4 ESS64430.1 - 7.4e-97 325.1 0.0 1.3e-96 324.3 0.0 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec3 CBFD_NFYB_HMF PF00808.18 ESS64430.1 - 0.018 15.0 0.4 0.06 13.4 0.3 1.9 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF972 PF06156.8 ESS64430.1 - 0.028 14.7 0.4 0.098 13.0 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Med9 PF07544.8 ESS64430.1 - 2.4 7.9 7.6 24 4.7 0.0 3.1 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PQQ_2 PF13360.1 ESS64431.1 - 0.011 15.1 0.0 0.39 10.1 0.0 2.8 2 1 0 2 2 2 0 PQQ-like domain Pribosyltran_N PF13793.1 ESS64432.1 - 3e-37 126.9 0.2 1.3e-35 121.6 0.1 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESS64432.1 - 5.3e-19 68.6 0.1 1.3e-17 64.1 0.0 2.5 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ESS64432.1 - 8.5e-09 35.2 0.0 1.5e-07 31.1 0.0 2.5 2 1 0 2 2 2 1 Phosphoribosyl transferase domain EF-hand_6 PF13405.1 ESS64433.1 - 2.9e-07 29.8 2.2 0.00024 20.7 0.2 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 ESS64433.1 - 3.2e-07 29.1 1.1 4.4e-05 22.4 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 ESS64433.1 - 6e-06 25.7 0.3 0.018 14.6 0.3 3.9 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_7 PF13499.1 ESS64433.1 - 1.3e-05 25.2 0.4 0.00041 20.4 0.1 2.9 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 ESS64433.1 - 0.0014 17.9 0.1 0.0068 15.6 0.2 2.2 2 0 0 2 2 2 1 EF hand DUF1126 PF06565.7 ESS64434.1 - 1.3e-17 62.9 0.2 3e-09 36.2 0.0 2.6 3 0 0 3 3 3 2 Repeat of unknown function (DUF1126) TPR_11 PF13414.1 ESS64435.1 - 5.2e-67 221.4 30.2 5.2e-19 67.6 0.4 6.2 6 0 0 6 6 6 6 TPR repeat TPR_1 PF00515.23 ESS64435.1 - 9.2e-51 167.4 30.5 5.7e-07 28.8 0.1 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.12 ESS64435.1 - 5.4e-45 147.7 33.0 1.9e-05 24.1 0.0 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESS64435.1 - 7.6e-26 90.1 17.7 1.2e-06 28.9 0.0 6.5 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.1 ESS64435.1 - 6.9e-21 72.8 11.2 0.15 12.7 0.0 8.6 5 3 3 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.1 ESS64435.1 - 4.3e-19 68.2 27.1 1.8e-05 24.5 0.4 6.8 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESS64435.1 - 1.5e-17 61.9 24.9 0.0092 15.6 0.0 8.7 8 1 1 9 9 8 6 Tetratricopeptide repeat TPR_9 PF13371.1 ESS64435.1 - 1e-14 54.1 5.8 4.4e-05 23.2 0.0 5.9 4 2 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS64435.1 - 3.2e-13 49.8 15.5 0.014 15.7 0.2 6.4 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.1 ESS64435.1 - 6.1e-13 47.5 14.5 0.7 9.8 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat Apc3 PF12895.2 ESS64435.1 - 1.1e-11 44.6 28.1 3.5e-06 27.0 3.3 5.3 3 3 1 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESS64435.1 - 5.8e-10 38.5 22.3 0.014 15.5 0.4 8.7 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_3 PF07720.7 ESS64435.1 - 1.6e-05 24.5 12.1 0.032 14.0 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS64435.1 - 2.2e-05 24.2 14.9 0.41 10.5 0.1 7.1 8 0 0 8 8 8 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 ESS64435.1 - 5.2e-05 23.4 23.7 3.3 8.3 0.0 7.8 8 0 0 8 8 7 2 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESS64435.1 - 8.4e-05 21.7 12.6 1.8 7.8 0.0 6.4 6 0 0 6 6 6 2 SHNi-TPR TPR_10 PF13374.1 ESS64435.1 - 0.0032 17.3 24.2 0.34 10.9 0.2 7.7 9 0 0 9 9 8 2 Tetratricopeptide repeat DUF1780 PF08682.5 ESS64435.1 - 0.019 14.4 2.0 0.042 13.3 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1780) U79_P34 PF03064.11 ESS64435.1 - 0.2 11.1 6.9 0.37 10.2 4.8 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Bestrophin PF01062.16 ESS64435.1 - 0.52 9.2 1.6 1.8 7.4 0.9 1.9 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel DUF1993 PF09351.5 ESS64436.1 - 0.036 14.0 0.5 0.48 10.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) DUF2666 PF10869.3 ESS64436.1 - 0.14 12.1 0.1 0.14 12.1 0.1 2.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2666) zf-RING_2 PF13639.1 ESS64437.1 - 4.4e-12 45.6 6.7 7.6e-12 44.8 4.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESS64437.1 - 5.6e-10 39.1 5.3 9.8e-10 38.4 3.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESS64437.1 - 5.7e-07 29.4 5.7 9.9e-07 28.6 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS64437.1 - 4.3e-06 26.2 3.1 7e-06 25.6 2.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS64437.1 - 1.1e-05 25.0 4.9 1.7e-05 24.4 3.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESS64437.1 - 0.00014 21.4 4.4 0.00023 20.7 3.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.1 ESS64437.1 - 0.00062 19.7 0.4 0.00085 19.3 0.3 1.3 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-Apc11 PF12861.2 ESS64437.1 - 0.0015 18.3 4.9 0.0041 16.9 3.4 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ESS64437.1 - 0.0055 16.3 3.1 0.012 15.2 2.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-HC5HC2H PF13771.1 ESS64437.1 - 0.0072 16.4 0.4 0.011 15.9 0.3 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain CwfJ_C_1 PF04677.10 ESS64437.1 - 0.11 12.1 0.4 0.16 11.6 0.3 1.2 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 zf-C3HC4_4 PF15227.1 ESS64437.1 - 0.17 11.7 2.3 0.39 10.6 1.6 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 ESS64437.1 - 0.31 11.1 5.7 0.9 9.6 4.0 1.8 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 ESS64437.1 - 0.87 9.5 5.3 1.5 8.8 3.7 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain DUF1423 PF07227.6 ESS64437.1 - 1.9 7.0 6.1 2.6 6.5 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) Exo_endo_phos_2 PF14529.1 ESS64438.1 - 2.1e-15 56.3 0.0 3.4e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESS64438.1 - 0.00084 19.3 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SLBP_RNA_bind PF15247.1 ESS64438.1 - 0.098 12.4 0.6 5.3 6.8 0.0 2.6 1 1 1 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain RVT_1 PF00078.22 ESS64439.1 - 2.6e-15 56.3 0.0 3.3e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESS64440.1 - 9.2e-10 38.9 0.0 1.5e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_jaz PF12171.3 ESS64440.1 - 0.18 11.9 3.7 7.2 6.8 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DAN PF03045.10 ESS64440.1 - 0.19 11.1 2.4 0.23 10.8 0.0 2.3 2 0 0 2 2 2 0 DAN domain zf-Di19 PF05605.7 ESS64440.1 - 1.2 9.3 7.2 4.6 7.4 5.0 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Peptidase_M8 PF01457.11 ESS64445.1 - 4.4e-49 167.2 0.0 5.6e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin DUF2142 PF09913.4 ESS64447.1 - 9.3 4.7 7.5 21 3.6 5.2 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2142) Peptidase_M8 PF01457.11 ESS64448.1 - 6.6e-59 199.6 0.0 8.5e-59 199.2 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M10 PF00413.19 ESS64448.1 - 0.029 14.0 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Matrixin Peptidase_M7 PF02031.11 ESS64448.1 - 0.048 13.3 0.0 3.8 7.2 0.0 2.3 1 1 1 2 2 2 0 Streptomyces extracellular neutral proteinase (M7) family DUF3810 PF12725.2 ESS64448.1 - 0.07 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Mucin PF01456.12 ESS64451.1 - 6.9e-27 93.9 34.1 7.9e-27 93.7 23.6 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein TraV PF09676.5 ESS64451.1 - 0.035 14.8 5.5 0.035 14.7 3.8 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Pex14_N PF04695.8 ESS64451.1 - 0.078 13.0 5.3 0.089 12.8 3.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4658 PF15555.1 ESS64451.1 - 0.34 10.7 4.3 1 9.2 3.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) PRCC PF10253.4 ESS64451.1 - 2.5 8.7 6.8 2.6 8.7 4.7 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Menin PF05053.8 ESS64451.1 - 3.4 5.7 5.5 3.5 5.6 3.8 1.0 1 0 0 1 1 1 0 Menin Spc7 PF08317.6 ESS64452.1 - 0.0021 16.7 1.5 0.003 16.2 1.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein IFT57 PF10498.4 ESS64452.1 - 0.011 14.5 2.9 0.016 14.0 2.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 ATP-synt_D PF01813.12 ESS64452.1 - 0.027 14.0 0.3 0.057 12.9 0.2 1.4 1 0 0 1 1 1 0 ATP synthase subunit D Atg14 PF10186.4 ESS64452.1 - 0.081 11.8 4.5 0.15 10.9 3.1 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 YlqD PF11068.3 ESS64452.1 - 0.64 10.0 4.5 1.2 9.1 3.1 1.4 1 0 0 1 1 1 0 YlqD protein IncA PF04156.9 ESS64452.1 - 0.94 9.0 6.2 1.5 8.3 4.3 1.2 1 0 0 1 1 1 0 IncA protein DUF4407 PF14362.1 ESS64452.1 - 1 8.2 6.7 1.8 7.4 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Myosin_head PF00063.16 ESS64454.1 - 1.1e-170 569.0 0.0 3.8e-170 567.2 0.0 1.7 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.14 ESS64454.1 - 0.031 13.9 0.0 0.076 12.7 0.0 1.7 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_22 PF13401.1 ESS64454.1 - 0.038 14.1 0.0 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF3321 PF11968.3 ESS64454.1 - 0.044 13.4 0.5 0.36 10.4 0.0 2.7 4 0 0 4 4 4 0 Putative methyltransferase (DUF3321) T2SE PF00437.15 ESS64454.1 - 0.079 11.8 0.1 0.43 9.4 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_17 PF13207.1 ESS64454.1 - 0.11 13.3 1.8 0.45 11.3 0.1 3.0 2 1 0 2 2 2 0 AAA domain DAO PF01266.19 ESS64455.1 - 3.9e-40 137.8 0.2 8.8e-40 136.6 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 ESS64455.1 - 3.4e-05 23.1 0.4 6.9e-05 22.0 0.3 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESS64455.1 - 0.0016 17.3 0.3 0.016 14.1 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 ESS64455.1 - 0.019 14.8 0.6 0.048 13.5 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESS64455.1 - 0.082 11.9 2.1 0.52 9.3 0.3 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.1 ESS64455.1 - 0.098 12.6 0.8 0.29 11.1 0.5 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 ESS64455.1 - 0.16 10.7 0.6 0.76 8.5 0.1 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox PF00070.22 ESS64455.1 - 0.2 12.0 2.4 0.28 11.6 0.3 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NADH-u_ox-rdase PF10785.4 ESS64456.1 - 7.6e-20 70.9 2.5 7.6e-20 70.9 1.8 1.9 3 0 0 3 3 3 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF4137 PF13593.1 ESS64458.1 - 2.9e-77 259.8 22.8 2.9e-77 259.8 15.8 1.6 2 0 0 2 2 2 1 SBF-like CPA transporter family (DUF4137) DUF4190 PF13828.1 ESS64458.1 - 1.1 8.8 6.7 0.12 11.9 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) Peptidase_M8 PF01457.11 ESS64459.1 - 3.1e-85 286.5 0.2 4.3e-85 286.0 0.1 1.2 1 0 0 1 1 1 1 Leishmanolysin HEAT_2 PF13646.1 ESS64460.1 - 1.9e-07 31.2 1.4 0.00037 20.7 0.1 3.1 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.17 ESS64460.1 - 0.00058 19.7 8.5 9.4 6.6 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat Mic1 PF07035.7 ESS64460.1 - 0.0079 15.5 0.5 0.022 14.1 0.3 1.7 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like TIP120 PF08623.5 ESS64460.1 - 0.019 14.5 0.1 0.042 13.4 0.1 1.5 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) Abhydro_lipase PF04083.11 ESS64460.1 - 0.026 13.8 0.0 0.064 12.6 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Vac14_Fab1_bd PF12755.2 ESS64460.1 - 0.057 13.8 0.0 0.81 10.1 0.0 2.6 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region Prok-E2_E PF14462.1 ESS64462.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family E RNB PF00773.14 ESS64463.1 - 1.9e-92 310.0 1.2 2.9e-92 309.4 0.8 1.2 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 ESS64463.1 - 2.1e-07 31.0 0.0 5.3e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 PIN domain OB_RNB PF08206.6 ESS64463.1 - 0.024 14.1 0.0 0.1 12.1 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF4611 PF15387.1 ESS64464.1 - 0.001 19.1 1.6 0.0026 17.8 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) DUF506 PF04720.7 ESS64464.1 - 0.11 12.0 0.7 1.7 8.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF506) PBP1_TM PF14812.1 ESS64464.1 - 0.52 10.6 5.0 1.1 9.6 3.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ThiF PF00899.16 ESS64466.1 - 0.00015 21.5 0.4 0.00029 20.6 0.0 1.6 2 0 0 2 2 2 1 ThiF family BON PF04972.12 ESS64466.1 - 0.0011 18.6 0.3 0.0043 16.7 0.0 2.1 2 0 0 2 2 2 1 BON domain OSTbeta PF15048.1 ESS64469.1 - 0.061 13.3 0.1 3 7.9 0.0 2.3 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein ATP-grasp_4 PF13535.1 ESS64472.1 - 4.2e-29 101.5 0.0 1.5e-19 70.4 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESS64472.1 - 3.9e-11 42.2 0.0 6.1e-09 35.0 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 ESS64472.1 - 6.1e-07 29.4 0.0 9.6e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 ESS64472.1 - 0.0002 20.7 0.0 0.00098 18.4 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.8 ESS64472.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus SeleniumBinding PF11524.3 ESS64472.1 - 0.015 15.4 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Selenium binding protein RimK PF08443.6 ESS64472.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.5 1 0 0 1 1 1 0 RimK-like ATP-grasp domain WD40 PF00400.27 ESS64473.1 - 1.1e-39 132.8 29.9 1.5e-06 27.8 0.2 10.4 10 0 0 10 10 10 8 WD domain, G-beta repeat PQQ_3 PF13570.1 ESS64473.1 - 0.0025 18.0 5.9 53 4.2 0.0 6.4 5 1 1 6 6 6 0 PQQ-like domain Coatomer_WDAD PF04053.9 ESS64473.1 - 0.11 11.3 0.0 2.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Coatomer WD associated region Nucleoporin_N PF08801.6 ESS64473.1 - 0.14 10.8 1.4 0.41 9.3 0.0 2.5 4 0 0 4 4 4 0 Nup133 N terminal like ETF_alpha PF00766.14 ESS64474.1 - 2.2e-35 120.1 0.1 3.3e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain AMP-binding PF00501.23 ESS64475.1 - 2.1e-56 191.1 0.2 2.5e-54 184.2 0.1 2.5 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 ESS64475.1 - 3.3e-09 37.5 0.0 9.7e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF2162 PF09930.4 ESS64476.1 - 0.16 11.0 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Predicted transporter (DUF2162) RasGEF_N PF00618.15 ESS64477.1 - 5.8e-13 48.8 0.1 1.5e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.14 ESS64477.1 - 8.5e-08 32.1 0.0 3.2e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 RasGEF domain PQ-loop PF04193.9 ESS64478.1 - 2.5e-33 113.4 20.5 3.6e-17 61.6 1.0 3.8 4 0 0 4 4 4 2 PQ loop repeat Sdh_cyt PF01127.17 ESS64478.1 - 4 7.2 9.5 1.5 8.6 1.9 2.8 1 1 2 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Skp1_POZ PF03931.10 ESS64482.1 - 4.9e-07 29.7 0.0 5.6e-06 26.3 0.0 2.1 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain zf-HIT PF04438.11 ESS64483.1 - 7.3e-06 25.5 11.1 1.7e-05 24.3 7.7 1.7 1 0 0 1 1 1 1 HIT zinc finger zf-CCCH PF00642.19 ESS64483.1 - 0.079 12.6 0.3 0.079 12.6 0.2 3.4 2 1 1 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS64483.1 - 0.28 11.2 7.7 4.5 7.4 0.3 3.6 3 1 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type PAPS_reduct PF01507.14 ESS64484.1 - 3.2e-19 69.4 0.0 3.3e-13 49.8 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.15 ESS64484.1 - 0.081 12.4 0.0 0.43 10.0 0.0 2.0 2 0 0 2 2 2 0 PP-loop family Aminotran_5 PF00266.14 ESS64486.1 - 4.2e-12 45.4 0.0 1.5e-11 43.7 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ESS64486.1 - 0.00047 19.3 0.0 0.0035 16.4 0.0 1.9 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 ESS64486.1 - 0.027 12.7 0.0 0.039 12.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Epimerase PF01370.16 ESS64487.1 - 3.2e-61 206.7 0.3 4.2e-61 206.3 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESS64487.1 - 6.2e-20 71.2 0.0 8.4e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 ESS64487.1 - 5.3e-18 64.8 0.3 3.6e-17 62.1 0.2 2.0 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 ESS64487.1 - 5e-17 61.7 0.0 1e-16 60.7 0.0 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESS64487.1 - 3.4e-16 58.7 0.1 4.8e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 ESS64487.1 - 0.00053 20.0 0.0 0.00092 19.2 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESS64487.1 - 0.0024 17.1 0.2 0.0081 15.4 0.2 1.8 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.20 ESS64487.1 - 0.13 12.1 0.1 0.54 10.1 0.0 2.1 2 1 0 2 2 2 0 short chain dehydrogenase RHSP PF07999.6 ESS64488.1 - 2e-69 234.2 1.2 4.7e-69 233.0 0.9 1.5 1 1 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS64489.1 - 1e-68 231.9 1.0 2.1e-68 230.9 0.7 1.5 1 1 0 1 1 1 1 Retrotransposon hot spot protein NPP PF08384.5 ESS64490.1 - 0.18 11.4 0.7 0.44 10.2 0.0 1.8 2 0 0 2 2 2 0 Pro-opiomelanocortin, N-terminal region Ribosomal_L38e PF01781.13 ESS64491.1 - 5.1e-31 106.2 4.0 6e-31 106.0 2.8 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family DUF3699 PF12480.3 ESS64491.1 - 0.14 11.8 0.1 0.19 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3699) AAA_16 PF13191.1 ESS64492.1 - 4.1e-05 23.6 9.4 0.0017 18.4 0.1 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 ESS64492.1 - 0.0016 18.5 0.9 1.3 9.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 ESS64492.1 - 0.0041 16.8 0.0 0.67 9.6 0.0 2.5 3 0 0 3 3 3 2 Archaeal ATPase Yip1 PF04893.12 ESS64493.1 - 0.0009 18.7 16.6 0.0017 17.8 11.5 1.4 1 0 0 1 1 1 1 Yip1 domain MIR PF02815.14 ESS64494.1 - 0.058 12.9 0.4 0.12 11.8 0.3 1.4 1 0 0 1 1 1 0 MIR domain PAT1 PF09770.4 ESS64495.1 - 8 4.5 8.7 9.7 4.2 6.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FtsJ PF01728.14 ESS64498.1 - 3.6e-05 23.8 0.0 6.4e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase RRM_5 PF13893.1 ESS64499.1 - 0.026 14.3 0.0 0.62 9.9 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 ESS64500.1 - 1.6e-15 56.9 0.2 0.00036 19.7 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain DUF2094 PF09867.4 ESS64500.1 - 0.08 12.8 0.0 21 4.9 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2094) Pkinase_Tyr PF07714.12 ESS64500.1 - 0.29 10.1 3.6 8.3 5.3 0.1 2.9 3 0 0 3 3 3 0 Protein tyrosine kinase Kdo PF06293.9 ESS64500.1 - 0.31 10.0 5.7 5.1 6.0 0.4 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4614 PF15391.1 ESS64500.1 - 2.1 8.0 18.9 0.88 9.3 0.1 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4614) Pkinase PF00069.20 ESS64501.1 - 6.1e-34 117.3 0.2 2.2e-15 56.4 0.0 3.9 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64501.1 - 4.8e-08 32.3 0.3 3.4e-06 26.3 0.0 3.2 4 0 0 4 4 4 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS64501.1 - 5.8e-05 22.1 0.2 0.039 12.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Metallophos PF00149.23 ESS64503.1 - 1.6e-20 73.3 0.1 3.8e-20 72.1 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_C48 PF02902.14 ESS64504.1 - 1.4e-16 60.8 0.1 1.8e-15 57.1 0.1 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Pkinase PF00069.20 ESS64505.1 - 1.7e-20 73.3 0.1 9e-10 38.1 0.0 2.7 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64505.1 - 2.7e-19 69.2 0.1 1.2e-09 37.6 0.0 3.2 3 1 0 3 3 3 2 Protein tyrosine kinase PQ-loop PF04193.9 ESS64507.1 - 1e-18 66.5 0.7 2e-18 65.7 0.0 1.9 2 0 0 2 2 2 1 PQ loop repeat DUF2301 PF10063.4 ESS64507.1 - 0.62 10.2 8.2 0.29 11.3 0.3 3.2 2 1 2 4 4 4 0 Uncharacterized integral membrane protein (DUF2301) UBX PF00789.15 ESS64508.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 UBX domain PHD PF00628.24 ESS64509.1 - 0.036 13.7 8.1 0.073 12.7 5.6 1.5 1 0 0 1 1 1 0 PHD-finger PolC_DP2 PF03833.8 ESS64509.1 - 0.076 10.6 0.7 0.11 10.2 0.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-HC5HC2H_2 PF13832.1 ESS64509.1 - 0.16 11.9 3.7 0.11 12.5 1.0 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain BUD22 PF09073.5 ESS64509.1 - 0.23 10.4 3.6 0.36 9.8 2.5 1.2 1 0 0 1 1 1 0 BUD22 SR-25 PF10500.4 ESS64509.1 - 0.8 9.1 11.3 1.8 7.9 7.8 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Yippee-Mis18 PF03226.9 ESS64509.1 - 0.88 9.6 5.2 7.8 6.6 1.1 3.0 1 1 2 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly C1_3 PF07649.7 ESS64509.1 - 1.9 8.6 5.4 0.4 10.7 1.3 1.7 2 0 0 2 2 2 0 C1-like domain Methyltransf_18 PF12847.2 ESS64510.1 - 1.6e-14 54.4 0.0 3.4e-14 53.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS64510.1 - 7.3e-14 51.7 0.0 1.2e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS64510.1 - 9.6e-12 44.7 0.0 3.4e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 ESS64510.1 - 1.3e-11 44.7 0.0 0.00022 21.6 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.7 ESS64510.1 - 1.5e-09 38.1 0.0 1.3e-08 35.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESS64510.1 - 6.2e-05 22.4 0.0 0.012 15.0 0.0 2.1 2 0 0 2 2 2 2 Nodulation protein S (NodS) Methyltransf_25 PF13649.1 ESS64510.1 - 0.00015 22.0 0.0 0.00051 20.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS64510.1 - 0.0012 18.9 0.0 0.0027 17.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain TPMT PF05724.6 ESS64510.1 - 0.0025 17.3 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) tRNA_U5-meth_tr PF05958.6 ESS64510.1 - 0.0038 15.9 0.0 0.0054 15.4 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_4 PF02390.12 ESS64510.1 - 0.012 14.6 0.0 0.05 12.6 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase PCMT PF01135.14 ESS64510.1 - 0.044 13.3 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF2841 PF11001.3 ESS64511.1 - 0.19 11.5 0.6 0.37 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2841) Pkinase PF00069.20 ESS64512.1 - 3.1e-27 95.3 0.0 5.6e-27 94.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64512.1 - 6.2e-15 54.9 0.0 8.9e-14 51.1 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESS64512.1 - 0.0023 17.6 3.1 0.026 14.2 0.0 2.9 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS64512.1 - 0.023 13.6 0.0 0.039 12.8 0.0 1.4 1 1 0 1 1 1 0 Kinase-like SCO1-SenC PF02630.9 ESS64514.1 - 3.2e-45 153.8 0.0 4.5e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 ESS64514.1 - 0.00097 18.8 0.0 0.0025 17.4 0.0 1.8 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 ESS64514.1 - 0.0032 17.5 0.0 0.0066 16.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like DUF553 PF04473.7 ESS64515.1 - 0.063 12.5 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like domain Pox_A_type_inc PF04508.7 ESS64515.1 - 0.31 10.9 4.8 4.4 7.3 0.3 3.7 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Sec1 PF00995.18 ESS64518.1 - 0.003 16.2 0.0 0.0033 16.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family TPR_14 PF13428.1 ESS64519.1 - 1.2e-06 28.5 8.2 3.2 8.6 0.0 7.5 5 2 3 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS64519.1 - 5.4e-05 22.7 0.1 0.18 11.4 0.0 4.4 3 1 1 4 4 4 1 TPR repeat Apc3 PF12895.2 ESS64519.1 - 0.00045 20.2 0.3 0.077 13.1 0.0 3.2 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESS64519.1 - 0.00073 19.2 0.0 0.28 11.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESS64519.1 - 0.0029 17.6 0.1 0.98 9.5 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS64519.1 - 0.0046 16.8 0.7 0.044 13.7 0.0 3.0 4 0 0 4 4 4 1 Tetratricopeptide repeat PRP1_N PF06424.7 ESS64519.1 - 0.0082 16.4 3.2 0.042 14.1 2.4 1.9 1 1 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_8 PF13181.1 ESS64519.1 - 0.013 15.2 0.0 0.068 12.9 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS64519.1 - 0.024 14.8 0.0 10 6.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS64519.1 - 0.025 14.1 0.0 0.11 12.1 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat cNMP_binding PF00027.24 ESS64521.1 - 9.5e-15 54.1 0.2 3.9e-06 26.5 0.0 4.2 3 2 0 3 3 3 3 Cyclic nucleotide-binding domain A_deaminase PF00962.17 ESS64523.1 - 3.5e-85 285.8 0.0 5.5e-61 206.2 0.0 2.5 2 1 0 2 2 2 2 Adenosine/AMP deaminase Med13_C PF06333.7 ESS64523.1 - 0.04 12.4 0.1 0.066 11.7 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal DUF1180 PF06679.7 ESS64524.1 - 0.64 9.8 4.6 0.69 9.7 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) NfeD PF01957.13 ESS64525.1 - 0.03 14.4 0.1 0.25 11.4 0.0 2.1 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF4131 PF13567.1 ESS64525.1 - 0.041 13.2 0.0 0.094 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4381 PF14316.1 ESS64525.1 - 5.2 7.1 7.6 9.5 6.3 0.2 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4381) WD40 PF00400.27 ESS64527.1 - 4.6e-05 23.1 3.5 2.4 8.1 0.0 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat zf-C2HC_2 PF13913.1 ESS64528.1 - 0.014 15.0 6.8 0.028 14.0 0.7 2.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF2574 PF10836.3 ESS64528.1 - 0.082 12.6 0.0 0.26 11.0 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2574) Complex1_LYR_2 PF13233.1 ESS64529.1 - 1.3e-15 57.7 0.0 3.2e-15 56.4 0.0 1.6 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 ESS64529.1 - 0.043 13.6 0.5 0.13 12.1 0.4 1.8 1 1 0 1 1 1 0 Complex 1 protein (LYR family) Sod_Fe_C PF02777.13 ESS64530.1 - 1.4e-30 105.2 0.6 2.8e-30 104.2 0.4 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 ESS64530.1 - 1.2e-17 63.9 0.1 3.2e-17 62.5 0.1 1.8 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain WW PF00397.21 ESS64531.1 - 1.1e-07 31.5 0.3 1.7e-07 30.9 0.2 1.3 1 0 0 1 1 1 1 WW domain APG6 PF04111.7 ESS64531.1 - 0.036 13.1 68.5 0.08 11.9 18.3 3.2 3 0 0 3 3 3 0 Autophagy protein Apg6 IncA PF04156.9 ESS64531.1 - 0.59 9.6 83.5 0.27 10.8 24.9 3.2 2 1 1 3 3 3 0 IncA protein SpoU_methylase PF00588.14 ESS64532.1 - 5e-23 81.5 0.0 1.3e-22 80.2 0.0 1.7 1 0 0 1 1 1 1 SpoU rRNA Methylase family Aa_trans PF01490.13 ESS64534.1 - 4.6e-57 193.3 26.5 5.8e-57 193.0 18.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Borrelia_lipo_2 PF06238.6 ESS64535.1 - 0.14 12.2 0.1 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Borrelia burgdorferi BBR25 lipoprotein EMP24_GP25L PF01105.19 ESS64536.1 - 0.34 10.5 1.9 4.7 6.8 0.7 2.2 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD ABC_tran PF00005.22 ESS64540.1 - 3.2e-24 85.7 0.0 4.7e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESS64540.1 - 6.6e-05 22.2 0.0 0.00023 20.4 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ESS64540.1 - 0.002 18.9 0.1 0.0075 17.0 0.1 1.8 2 1 0 2 2 1 1 AAA domain AAA_21 PF13304.1 ESS64540.1 - 0.0047 16.9 0.0 1.2 9.0 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.1 ESS64540.1 - 0.029 14.6 0.0 0.058 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESS64540.1 - 0.037 14.3 0.1 0.066 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS64540.1 - 0.05 13.5 0.5 0.12 12.3 0.1 1.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.1 ESS64540.1 - 0.052 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESS64540.1 - 0.053 12.9 0.0 0.097 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF4245 PF14030.1 ESS64540.1 - 0.064 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) DUF258 PF03193.11 ESS64540.1 - 0.082 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESS64540.1 - 0.1 12.1 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PRK PF00485.13 ESS64540.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 ESS64540.1 - 0.18 10.8 0.0 0.33 10.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin EF-hand_7 PF13499.1 ESS64543.1 - 0.00013 22.0 0.1 0.0027 17.7 0.1 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS64543.1 - 0.0018 18.0 0.0 0.05 13.5 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESS64543.1 - 0.0044 16.2 0.1 0.038 13.2 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 ESS64543.1 - 0.0064 15.7 0.0 0.017 14.4 0.0 1.8 1 0 0 1 1 1 1 EF hand BAMBI PF06211.7 ESS64543.1 - 0.082 12.9 0.8 3.9 7.5 0.0 3.1 3 0 0 3 3 3 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain zf-RanBP PF00641.13 ESS64544.1 - 3.8e-30 102.6 54.7 4.8e-08 31.9 1.2 6.4 6 0 0 6 6 6 6 Zn-finger in Ran binding protein and others DZR PF12773.2 ESS64544.1 - 0.0002 21.1 45.6 0.0017 18.1 8.0 5.2 1 1 4 5 5 5 4 Double zinc ribbon DUF35_N PF12172.3 ESS64544.1 - 0.028 14.3 1.4 0.028 14.3 0.9 5.9 6 0 0 6 6 6 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Paired_CXXCH_1 PF09699.5 ESS64544.1 - 6.6 6.3 17.4 1.5 8.3 0.8 4.4 4 1 0 4 4 4 0 Doubled CXXCH motif (Paired_CXXCH_1) Spt4 PF06093.8 ESS64544.1 - 9.8 6.1 15.3 1.2 9.0 0.8 4.1 4 0 0 4 4 4 0 Spt4/RpoE2 zinc finger Coatomer_WDAD PF04053.9 ESS64545.1 - 9.1e-141 469.6 0.0 1.3e-140 469.1 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 ESS64545.1 - 6.5e-40 133.6 0.3 6.4e-09 35.3 0.0 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat Peptidase_M41 PF01434.13 ESS64547.1 - 6.7e-45 153.1 0.1 9.4e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESS64547.1 - 1.9e-39 134.8 0.1 5e-39 133.5 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS64547.1 - 0.00014 20.9 0.2 0.001 18.1 0.0 2.4 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESS64547.1 - 0.00034 20.0 0.1 0.59 9.5 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.1 ESS64547.1 - 0.00037 20.6 0.0 0.036 14.2 0.0 3.0 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESS64547.1 - 0.00041 20.2 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 ESS64547.1 - 0.00062 19.4 0.0 0.0023 17.6 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 ESS64547.1 - 0.0013 19.5 0.0 0.0037 18.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS64547.1 - 0.0019 18.2 0.1 0.025 14.5 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 ESS64547.1 - 0.0042 16.9 0.0 0.02 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESS64547.1 - 0.0067 15.1 0.0 0.011 14.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESS64547.1 - 0.0073 15.7 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.9 ESS64547.1 - 0.023 14.4 0.3 0.15 11.7 0.2 2.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS64547.1 - 0.026 13.6 0.0 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TPR_11 PF13414.1 ESS64548.1 - 4.5e-15 55.0 0.5 4e-07 29.5 0.2 3.7 2 1 1 3 3 3 3 TPR repeat SET PF00856.23 ESS64548.1 - 2e-12 47.7 0.1 2e-11 44.4 0.0 2.5 3 0 0 3 3 3 1 SET domain TPR_12 PF13424.1 ESS64548.1 - 0.00051 19.9 6.5 0.022 14.6 0.2 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESS64548.1 - 0.0022 17.7 3.2 20 5.4 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat UPRTase PF14681.1 ESS64549.1 - 2.5e-69 232.6 0.0 3e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 ESS64549.1 - 3e-06 26.9 0.0 4.4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CoA_binding_2 PF13380.1 ESS64549.1 - 0.079 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 CoA binding domain EF-hand_7 PF13499.1 ESS64550.1 - 3.6e-07 30.2 0.2 5.6e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS64550.1 - 0.00011 21.8 1.3 0.0041 16.8 0.0 3.3 2 1 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 ESS64550.1 - 0.00075 18.6 2.8 0.011 15.0 0.0 3.4 3 1 1 4 4 4 1 EF hand EF-hand_9 PF14658.1 ESS64550.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.1 ESS64550.1 - 0.013 15.0 1.0 0.024 14.2 0.1 1.9 2 0 0 2 2 2 0 EF-hand domain pair Bap31 PF05529.7 ESS64550.1 - 4.9 6.5 5.0 2.4 7.5 1.1 2.0 1 1 0 2 2 2 0 B-cell receptor-associated protein 31-like N2227 PF07942.7 ESS64552.1 - 1.2e-94 316.3 0.0 1.6e-94 315.8 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein ELL PF10390.4 ESS64553.1 - 0.041 13.1 0.3 0.07 12.3 0.2 1.3 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL CDC14 PF08045.6 ESS64554.1 - 6.1e-05 22.2 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Cell division control protein 14, SIN component Fes1 PF08609.5 ESS64554.1 - 0.0026 18.2 0.3 0.007 16.8 0.1 1.8 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 Brevenin PF03032.10 ESS64554.1 - 0.018 14.8 4.2 0.018 14.8 2.9 2.0 2 0 0 2 2 2 0 Brevenin/esculentin/gaegurin/rugosin family TPR_MLP1_2 PF07926.7 ESS64555.1 - 0.16 11.7 12.1 0.67 9.6 0.5 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein MbeD_MobD PF04899.7 ESS64555.1 - 0.27 11.1 12.0 0.27 11.1 2.6 3.7 3 2 0 3 3 3 0 MbeD/MobD like SlyX PF04102.7 ESS64555.1 - 0.3 11.4 8.8 2.6 8.5 0.1 3.8 3 1 0 3 3 3 0 SlyX Spectrin PF00435.16 ESS64555.1 - 0.69 10.2 6.4 0.79 10.0 0.0 3.1 3 0 0 3 3 3 0 Spectrin repeat DUF641 PF04859.7 ESS64555.1 - 0.8 9.4 11.6 0.66 9.7 1.0 3.0 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) bZIP_1 PF00170.16 ESS64555.1 - 1.6 8.7 12.8 4.7 7.2 0.2 3.7 3 1 0 3 3 3 0 bZIP transcription factor CENP-Q PF13094.1 ESS64555.1 - 3.7 7.5 13.1 0.86 9.6 0.0 3.1 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Myosin_head PF00063.16 ESS64556.1 - 1.6e-216 720.5 0.0 2.5e-216 719.9 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 ESS64556.1 - 1e-15 57.5 0.0 3.9e-08 32.8 0.0 3.2 2 1 0 2 2 2 2 Myosin tail WW PF00397.21 ESS64556.1 - 4.2e-08 32.8 1.4 1.3e-07 31.3 1.0 1.9 1 0 0 1 1 1 1 WW domain FYVE PF01363.16 ESS64556.1 - 0.00053 19.8 10.3 0.001 18.8 7.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger Zeta_toxin PF06414.7 ESS64556.1 - 0.0018 17.3 0.0 0.0018 17.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.1 ESS64556.1 - 0.012 15.7 0.0 0.057 13.5 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESS64556.1 - 0.039 14.7 1.2 0.2 12.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.7 ESS64556.1 - 0.1 11.8 0.1 2.6 7.3 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.1 ESS64556.1 - 0.18 11.7 0.0 0.18 11.7 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 ESS64556.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.1 2 0 0 2 2 2 0 ABC transporter Amastin PF07344.6 ESS64557.1 - 1.8e-32 112.1 4.9 2.3e-32 111.7 2.9 1.5 2 0 0 2 2 2 1 Amastin surface glycoprotein AAA_16 PF13191.1 ESS64557.1 - 3.5e-05 23.8 0.0 5.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 ESS64557.1 - 0.0082 15.0 0.1 0.062 12.1 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain DUF2791 PF10923.3 ESS64557.1 - 0.026 13.1 0.0 0.04 12.5 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Zeta_toxin PF06414.7 ESS64557.1 - 0.068 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF4064 PF13273.1 ESS64557.1 - 0.25 11.4 6.2 0.57 10.3 0.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) DUF3815 PF12821.2 ESS64557.1 - 0.45 10.4 8.1 0.096 12.6 2.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3815) CorA PF01544.13 ESS64557.1 - 0.56 9.1 0.0 0.56 9.1 0.0 2.3 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein DUF2721 PF11026.3 ESS64557.1 - 1.9 8.1 8.5 2.2 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) YfhO PF09586.5 ESS64557.1 - 3.9 5.3 6.8 6.8 4.5 2.8 2.0 2 0 0 2 2 2 0 Bacterial membrane protein YfhO ERAP1_C PF11838.3 ESS64559.1 - 0.011 15.0 0.1 0.095 11.9 0.0 2.1 2 0 0 2 2 2 0 ERAP1-like C-terminal domain DUF964 PF06133.6 ESS64559.1 - 0.21 11.6 1.5 0.96 9.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF964) Rhodanese PF00581.15 ESS64560.1 - 7.3e-13 48.8 0.0 2.5e-05 24.6 0.0 3.5 2 1 0 2 2 2 2 Rhodanese-like domain Pkinase PF00069.20 ESS64561.1 - 6.6e-38 130.3 0.0 3.6e-37 127.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64561.1 - 1.9e-27 96.0 0.0 7.3e-20 71.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS64561.1 - 5.4e-05 23.0 0.1 0.00032 20.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS64561.1 - 0.039 12.9 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.6 ESS64561.1 - 0.19 10.5 0.1 0.31 9.8 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Phage_GPO PF05929.6 ESS64562.1 - 0.075 12.2 1.0 0.13 11.5 0.7 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Fmp27_WPPW PF10359.4 ESS64562.1 - 0.75 8.1 5.3 1.1 7.5 3.7 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FUSC-like PF12805.2 ESS64562.1 - 2.7 6.8 6.1 3.9 6.3 4.2 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS TEX13 PF15186.1 ESS64562.1 - 8 6.0 8.8 19 4.8 6.1 1.6 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family DUF2992 PF11208.3 ESS64564.1 - 0.12 12.2 0.2 0.22 11.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) HEPN PF05168.9 ESS64567.1 - 0.089 12.6 1.0 0.44 10.4 0.4 2.3 2 1 0 2 2 2 0 HEPN domain Ribosomal_L13 PF00572.13 ESS64569.1 - 1.8e-20 73.3 0.1 3.6e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L13 Metallophos PF00149.23 ESS64570.1 - 1.4e-34 119.2 0.0 1.7e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 ESS64570.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 PPP5 TPR repeat region Metallophos PF00149.23 ESS64571.1 - 4.5e-30 104.5 0.0 6.1e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NAD_binding_10 PF13460.1 ESS64572.1 - 3e-10 40.3 0.1 0.00073 19.5 0.0 2.3 2 0 0 2 2 2 2 NADH(P)-binding 3Beta_HSD PF01073.14 ESS64572.1 - 1.5e-06 27.1 0.0 5.5e-06 25.2 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 ESS64572.1 - 0.00067 18.9 0.1 0.0026 17.0 0.1 1.8 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 ESS64572.1 - 0.0089 14.9 0.0 0.016 14.1 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 ESS64572.1 - 0.012 15.0 0.0 0.14 11.5 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family CBF PF03914.12 ESS64574.1 - 1.9e-37 128.2 0.7 3.5e-37 127.3 0.0 1.7 2 0 0 2 2 2 1 CBF/Mak21 family SpoIIE PF07228.7 ESS64575.1 - 1.5e-10 41.1 0.0 2.1e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESS64575.1 - 1.9e-05 24.2 0.0 3.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 ESS64575.1 - 0.011 15.1 0.0 0.95 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein phosphatase 2C Sod_Fe_C PF02777.13 ESS64576.1 - 4.3e-07 29.7 0.1 3.4e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Tcp10_C PF07202.8 ESS64576.1 - 0.0036 16.8 0.0 0.0061 16.1 0.0 1.4 1 0 0 1 1 1 1 T-complex protein 10 C-terminus FAST_1 PF06743.10 ESS64577.1 - 0.36 10.5 3.9 0.44 10.2 0.0 3.1 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 DUF2039 PF10217.4 ESS64578.1 - 1.6e-28 98.5 14.5 2.9e-28 97.7 10.1 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) DUF2797 PF10977.3 ESS64578.1 - 0.019 14.6 4.7 0.033 13.8 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Cript PF10235.4 ESS64578.1 - 0.11 12.9 7.2 0.27 11.6 5.0 1.6 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Tweety PF04906.8 ESS64579.1 - 0.029 12.7 0.0 0.029 12.7 0.0 4.5 4 1 1 5 5 5 0 Tweety ELO PF01151.13 ESS64580.1 - 1.8e-47 161.7 18.2 2.8e-47 161.1 12.6 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Reo_sigmaC PF04582.7 ESS64581.1 - 0.0002 20.6 28.6 0.0043 16.2 4.7 4.1 1 1 2 4 4 4 3 Reovirus sigma C capsid protein DUF2968 PF11180.3 ESS64581.1 - 0.003 16.9 5.3 0.003 16.9 3.7 6.1 2 2 4 6 6 6 1 Protein of unknown function (DUF2968) MscS_porin PF12795.2 ESS64581.1 - 0.0047 16.2 16.5 0.0047 16.2 11.5 5.0 2 2 2 4 4 4 2 Mechanosensitive ion channel porin domain Cast PF10174.4 ESS64581.1 - 0.0059 14.7 84.9 0.16 9.9 26.7 4.1 1 1 2 3 3 3 2 RIM-binding protein of the cytomatrix active zone TMF_DNA_bd PF12329.3 ESS64581.1 - 0.01 15.6 3.2 0.01 15.6 2.2 8.0 5 2 1 6 6 6 0 TATA element modulatory factor 1 DNA binding ATG16 PF08614.6 ESS64581.1 - 0.028 14.2 80.1 0.95 9.2 13.4 5.3 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.14 ESS64581.1 - 0.55 7.8 89.5 1.1 6.8 26.2 3.3 1 1 3 4 4 4 0 Myosin tail WEMBL PF05701.6 ESS64581.1 - 0.6 8.4 88.4 0.54 8.6 23.7 4.1 1 1 2 3 3 3 0 Weak chloroplast movement under blue light Filament PF00038.16 ESS64581.1 - 2.1 7.7 74.6 0.021 14.3 21.9 3.9 2 1 0 3 3 3 0 Intermediate filament protein NPV_P10 PF05531.7 ESS64581.1 - 7.8 6.8 37.3 0.16 12.2 0.7 7.6 6 3 0 6 6 6 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 ESS64582.1 - 0.1 11.7 2.0 0.2 10.7 0.1 2.1 1 1 0 2 2 2 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 ESS64584.1 - 0.16 12.2 13.7 0.48 10.7 0.5 5.5 6 1 0 6 6 6 0 Nucleopolyhedrovirus P10 protein Tnp_P_element PF12017.3 ESS64584.1 - 2.3 7.4 13.0 0.25 10.5 1.3 3.5 3 0 0 3 3 3 0 Transposase protein Snapin_Pallidin PF14712.1 ESS64584.1 - 3.4 8.0 40.9 0.5 10.7 2.0 6.3 4 2 2 6 6 6 0 Snapin/Pallidin Filament PF00038.16 ESS64584.1 - 7.6 5.9 55.7 0.41 10.0 4.7 4.0 3 1 1 4 4 4 0 Intermediate filament protein Baculo_PEP_C PF04513.7 ESS64584.1 - 8.3 6.2 13.2 8.5 6.2 0.2 4.7 3 2 3 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vault PF01505.13 ESS64585.1 - 1.4e-63 210.6 6.9 2e-14 53.3 0.0 6.7 7 0 0 7 7 7 5 Major Vault Protein repeat MVP_shoulder PF11978.3 ESS64585.1 - 5.4e-51 171.4 0.1 1.6e-50 169.8 0.0 1.9 2 0 0 2 2 2 1 Shoulder domain Pkinase PF00069.20 ESS64586.1 - 7.4e-57 192.4 0.0 1.2e-56 191.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64586.1 - 1.7e-24 86.3 0.0 1.3e-21 76.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS64586.1 - 0.00024 20.9 0.3 0.00086 19.1 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS64586.1 - 0.00063 19.1 0.4 0.0011 18.3 0.3 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESS64586.1 - 0.029 13.4 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESS64586.1 - 0.13 11.6 0.1 0.2 10.9 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DEAD PF00270.24 ESS64587.1 - 3.8e-40 137.1 0.0 8.9e-39 132.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase GUCT PF08152.7 ESS64587.1 - 2e-26 91.8 0.0 4.3e-26 90.7 0.0 1.6 1 0 0 1 1 1 1 GUCT (NUC152) domain Helicase_C PF00271.26 ESS64587.1 - 3.8e-24 84.3 0.0 8.6e-24 83.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS64587.1 - 0.0025 17.6 0.1 0.044 13.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit LRR_6 PF13516.1 ESS64588.1 - 2.3e-23 79.5 13.6 0.0015 18.3 0.0 8.8 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.2 ESS64588.1 - 5.4e-10 38.6 2.7 0.0039 16.7 0.0 4.7 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS64588.1 - 2e-05 23.9 6.6 24 5.4 0.0 6.7 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.1 ESS64588.1 - 0.00051 19.7 4.3 3.8 7.3 0.1 4.9 4 2 0 4 4 4 2 Leucine rich repeat LRR_7 PF13504.1 ESS64588.1 - 0.14 12.4 5.5 1.9e+02 2.9 0.0 5.9 6 0 0 6 6 6 0 Leucine rich repeat Metallophos PF00149.23 ESS64589.1 - 3.9e-29 101.4 0.2 6.1e-29 100.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESS64589.1 - 0.00043 20.1 0.0 0.00076 19.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Methyltransf_4 PF02390.12 ESS64590.1 - 2e-05 23.7 0.0 2.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase CENP-F_leu_zip PF10473.4 ESS64591.1 - 4.6e-05 23.3 8.8 4.6e-05 23.3 6.1 5.1 2 2 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WEMBL PF05701.6 ESS64591.1 - 0.55 8.6 51.5 0.016 13.6 19.6 2.5 1 1 1 2 2 2 0 Weak chloroplast movement under blue light DUF3584 PF12128.3 ESS64591.1 - 1.3 6.2 52.8 0.091 10.0 9.7 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Sec8_exocyst PF04048.9 ESS64591.1 - 3.6 7.2 16.5 0.58 9.7 0.3 4.5 3 1 1 5 5 5 0 Sec8 exocyst complex component specific domain OstA PF03968.9 ESS64592.1 - 1 9.3 7.3 4.6 7.2 0.0 3.2 3 1 0 3 3 3 0 OstA-like protein 2-oxoacid_dh PF00198.18 ESS64593.1 - 5.5e-77 258.1 0.1 6.9e-77 257.8 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 ESS64593.1 - 2.9e-16 58.8 0.6 6e-16 57.8 0.4 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 ESS64593.1 - 1.9e-13 49.7 0.0 3.8e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 e3 binding domain Fip1 PF05182.8 ESS64594.1 - 9.9e-20 69.5 0.5 1.5e-19 68.9 0.3 1.3 1 0 0 1 1 1 1 Fip1 motif zf-CCCH PF00642.19 ESS64594.1 - 4.3e-06 26.2 1.6 7.2e-06 25.5 1.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MMR_HSR1 PF01926.18 ESS64596.1 - 4.7e-15 55.5 0.0 1.3e-14 54.1 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS64596.1 - 2.1e-06 27.1 0.0 3.2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.11 ESS64596.1 - 5.2e-05 22.4 1.0 0.00012 21.3 0.0 1.9 2 0 0 2 2 2 1 AIG1 family Miro PF08477.8 ESS64596.1 - 0.016 15.7 0.0 0.038 14.4 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein DUF258 PF03193.11 ESS64596.1 - 0.031 13.4 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Dynamin_N PF00350.18 ESS64596.1 - 0.034 13.9 1.7 0.3 10.8 0.1 2.8 2 1 1 3 3 3 0 Dynamin family Peptidase_S9_N PF02897.10 ESS64597.1 - 0.044 12.3 0.0 0.4 9.1 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.16 ESS64598.1 - 1.1e-28 99.8 0.0 3.4e-27 95.0 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF736 PF05284.7 ESS64598.1 - 0.11 12.3 0.1 12 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF736) zf-C3HC4_3 PF13920.1 ESS64600.1 - 2.9e-07 30.0 2.5 5.4e-07 29.1 1.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS64600.1 - 1.4e-06 27.8 3.7 2.5e-06 27.1 2.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESS64600.1 - 3.2e-06 27.0 7.7 6.1e-06 26.1 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS64600.1 - 1.5e-05 24.7 8.8 2.8e-05 23.9 6.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 ESS64600.1 - 2.4e-05 23.8 3.2 4.3e-05 23.0 2.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS64600.1 - 0.00034 20.3 7.6 0.00062 19.5 5.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 ESS64600.1 - 0.00066 19.3 2.6 0.0016 18.0 1.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESS64600.1 - 0.015 15.1 2.9 0.037 13.8 2.0 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein HypA PF01155.14 ESS64600.1 - 0.018 14.7 0.2 0.018 14.7 0.1 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-RING_4 PF14570.1 ESS64600.1 - 0.034 13.7 1.2 0.077 12.6 0.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Fib_alpha PF08702.5 ESS64600.1 - 9.5 6.3 9.2 10 6.2 0.4 3.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DEAD PF00270.24 ESS64601.1 - 1.3e-39 135.4 0.1 1.3e-38 132.1 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS64601.1 - 5.9e-20 70.9 0.0 1.5e-19 69.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESS64601.1 - 1.5e-14 53.3 0.3 3.2e-14 52.2 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESS64601.1 - 0.022 14.5 1.7 0.064 13.0 0.0 2.6 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Zip PF02535.17 ESS64604.1 - 1.3e-10 40.8 12.0 8.5e-09 34.8 0.3 2.5 2 1 1 3 3 3 2 ZIP Zinc transporter HEAT PF02985.17 ESS64607.1 - 6.6e-07 28.8 0.6 0.054 13.5 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat UVR PF02151.14 ESS64607.1 - 0.0012 18.2 0.5 0.0012 18.2 0.3 2.8 3 0 0 3 3 3 1 UvrB/uvrC motif Cnd1 PF12717.2 ESS64607.1 - 0.05 13.4 1.4 10 5.9 0.0 3.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 ESS64607.1 - 0.069 12.9 1.1 6.3 6.7 0.4 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 ESS64607.1 - 0.68 10.4 3.4 13 6.3 0.5 3.0 3 0 0 3 3 3 0 HEAT-like repeat WD40 PF00400.27 ESS64608.1 - 3.5e-41 137.6 17.9 1.9e-08 33.8 0.0 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat PQQ_3 PF13570.1 ESS64608.1 - 0.026 14.8 4.9 12 6.3 0.0 4.4 4 0 0 4 4 4 0 PQQ-like domain DUF3312 PF11768.3 ESS64608.1 - 0.084 11.0 0.1 3.6 5.6 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3312) FOP_dimer PF09398.5 ESS64609.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 FOP N terminal dimerisation domain Herpes_UL52 PF03121.10 ESS64611.1 - 5.3e-14 51.7 0.1 1.3e-13 50.4 0.1 1.7 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase Nicastrin PF05450.10 ESS64612.1 - 1.4e-09 37.5 0.0 2.9e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.12 ESS64612.1 - 0.00011 21.9 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 ESS64612.1 - 0.0014 18.1 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 LysM PF01476.15 ESS64613.1 - 1.2e-06 28.3 0.0 0.081 12.8 0.0 3.1 3 0 0 3 3 3 2 LysM domain Histone PF00125.19 ESS64614.1 - 2.2e-11 43.6 0.1 2.8e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESS64614.1 - 0.013 15.5 0.2 0.04 13.9 0.0 1.8 1 1 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 ESS64614.1 - 0.026 14.3 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TAF PF02969.12 ESS64614.1 - 0.026 14.4 0.2 0.043 13.7 0.1 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) Bromo_TP PF07524.8 ESS64614.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated Rrp15p PF07890.7 ESS64618.1 - 8.2e-08 32.3 18.6 1.7e-06 28.1 12.9 2.0 1 1 0 1 1 1 1 Rrp15p MBF1 PF08523.5 ESS64618.1 - 0.06 13.3 0.6 0.06 13.3 0.4 2.5 3 1 0 3 3 3 0 Multiprotein bridging factor 1 SPOUT_MTase PF02590.12 ESS64618.1 - 0.1 12.2 2.9 1.6 8.3 0.3 2.3 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase PsaN PF05479.6 ESS64618.1 - 0.22 11.4 0.2 0.22 11.4 0.1 2.2 2 0 0 2 2 2 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) ADIP PF11559.3 ESS64619.1 - 0.002 18.0 8.8 0.0022 17.9 6.1 1.0 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF4631 PF15450.1 ESS64619.1 - 0.0024 16.2 3.5 0.0026 16.1 2.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4631) HAP1_N PF04849.8 ESS64619.1 - 0.0061 15.5 1.9 0.0072 15.3 1.3 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region MscS_porin PF12795.2 ESS64619.1 - 0.01 15.1 9.0 0.18 11.1 2.1 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Myosin_tail_1 PF01576.14 ESS64619.1 - 0.018 12.8 4.1 0.02 12.6 2.9 1.0 1 0 0 1 1 1 0 Myosin tail Spc7 PF08317.6 ESS64619.1 - 0.048 12.3 1.4 0.057 12.0 1.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIVA PF05103.8 ESS64619.1 - 0.054 13.5 3.4 0.068 13.2 1.5 1.6 1 1 1 2 2 2 0 DivIVA protein MitMem_reg PF13012.1 ESS64619.1 - 0.055 13.5 2.2 0.16 12.0 0.2 1.9 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Arfaptin PF06456.8 ESS64619.1 - 0.071 12.4 2.3 0.082 12.2 1.6 1.0 1 0 0 1 1 1 0 Arfaptin-like domain GldM_N PF12081.3 ESS64619.1 - 0.072 12.5 0.8 0.09 12.2 0.5 1.1 1 0 0 1 1 1 0 GldM N-terminal domain DUF1664 PF07889.7 ESS64619.1 - 0.077 12.8 1.7 0.09 12.5 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sec8_exocyst PF04048.9 ESS64619.1 - 0.099 12.2 2.4 0.14 11.7 1.0 1.6 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain UPF0242 PF06785.6 ESS64619.1 - 0.13 10.9 3.3 0.16 10.6 2.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Vps53_N PF04100.7 ESS64619.1 - 0.14 10.9 1.4 0.16 10.7 1.0 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal GTPase_Cys_C PF12631.2 ESS64619.1 - 0.14 12.5 1.2 0.19 12.1 0.6 1.5 1 1 0 1 1 1 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE DUF3552 PF12072.3 ESS64619.1 - 0.15 11.2 3.8 0.16 11.1 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) IncA PF04156.9 ESS64619.1 - 0.18 11.4 3.0 0.21 11.1 2.1 1.1 1 0 0 1 1 1 0 IncA protein HALZ PF02183.13 ESS64619.1 - 0.19 11.4 4.5 1.8 8.3 0.1 2.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper Lectin_N PF03954.9 ESS64619.1 - 0.28 10.5 3.0 0.35 10.2 2.1 1.1 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Mod_r PF07200.8 ESS64619.1 - 0.32 10.9 3.5 0.7 9.8 2.4 1.6 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF972 PF06156.8 ESS64619.1 - 0.37 11.1 3.8 1.3 9.3 2.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ESS64619.1 - 0.52 10.6 4.4 0.84 9.9 3.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF904) KxDL PF10241.4 ESS64619.1 - 0.69 9.8 3.2 3.5 7.5 2.3 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein TMF_DNA_bd PF12329.3 ESS64619.1 - 0.89 9.4 4.0 1.2 8.9 2.7 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.6 ESS64619.1 - 1.8 8.4 4.5 1.9 8.3 1.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Dynein_light PF01221.13 ESS64620.1 - 7e-32 109.2 1.2 7.2e-32 109.2 0.8 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Vasohibin PF14822.1 ESS64620.1 - 0.0083 15.2 0.1 0.0091 15.0 0.0 1.2 1 0 0 1 1 1 1 Vasohibin PseudoU_synth_2 PF00849.17 ESS64620.1 - 0.14 11.9 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA pseudouridylate synthase AMP-binding PF00501.23 ESS64621.1 - 2.5e-05 22.8 0.5 3.1e-05 22.5 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.23 ESS64622.1 - 8.4e-09 34.3 0.0 9.1e-06 24.3 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme adh_short PF00106.20 ESS64623.1 - 1.1e-20 74.2 0.4 1.7e-20 73.6 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS64623.1 - 1.6e-09 37.6 0.2 2.5e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 ESS64623.1 - 3.6e-05 23.8 0.1 5.9e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESS64623.1 - 9.2e-05 21.9 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESS64623.1 - 0.0031 17.3 0.0 0.0045 16.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 2-Hacid_dh_C PF02826.14 ESS64623.1 - 0.023 13.8 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SPC25 PF06703.6 ESS64623.1 - 0.023 14.2 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) NAD_binding_7 PF13241.1 ESS64623.1 - 0.044 14.0 0.1 0.098 12.9 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 ESS64623.1 - 0.079 12.6 0.3 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Nol1_Nop2_Fmu PF01189.12 ESS64623.1 - 0.08 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 NOL1/NOP2/sun family Pyr_redox PF00070.22 ESS64623.1 - 0.13 12.7 0.1 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.20 ESS64624.1 - 1.7e-17 63.8 0.1 3.8e-17 62.7 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ESS64624.1 - 1.1e-09 38.2 0.0 3.4e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESS64624.1 - 6.4e-07 29.3 0.0 1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ESS64624.1 - 1.8e-05 24.3 0.0 2.9e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESS64624.1 - 0.0023 17.9 0.0 0.069 13.1 0.0 2.6 1 1 0 1 1 1 1 NADH(P)-binding Abhydrolase_2 PF02230.11 ESS64625.1 - 4.2e-45 153.8 0.0 6e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 ESS64625.1 - 8e-14 51.6 0.2 1.2e-13 51.0 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS64625.1 - 2.9e-09 37.1 2.0 0.00015 21.7 1.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS64625.1 - 6.3e-07 28.8 0.0 0.00055 19.2 0.0 3.0 3 0 0 3 3 3 1 Prolyl oligopeptidase family LIP PF03583.9 ESS64625.1 - 5.2e-05 22.5 1.5 0.0018 17.5 0.0 2.2 1 1 1 2 2 2 1 Secretory lipase DLH PF01738.13 ESS64625.1 - 0.00031 20.0 0.1 0.00054 19.3 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Cutinase PF01083.17 ESS64625.1 - 0.012 15.3 1.0 0.15 11.7 0.2 2.1 1 1 1 2 2 2 0 Cutinase FSH1 PF03959.8 ESS64625.1 - 0.039 13.3 0.0 0.15 11.4 0.0 2.0 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydro_lipase PF04083.11 ESS64625.1 - 0.056 12.8 0.2 0.45 9.8 0.1 2.4 2 1 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Abhydrolase_4 PF08386.5 ESS64625.1 - 0.099 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DUF563 PF04577.9 ESS64628.1 - 4e-21 75.8 0.1 7.3e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Complex1_49kDa PF00346.14 ESS64629.1 - 0.068 12.1 0.1 0.61 9.0 0.0 2.0 2 0 0 2 2 2 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit SPRY PF00622.23 ESS64632.1 - 6.7e-09 35.8 0.0 2.5e-08 34.0 0.0 2.0 1 1 0 1 1 1 1 SPRY domain Ig_J_chain PF15097.1 ESS64632.1 - 0.094 12.3 0.1 0.22 11.1 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin J chain Mito_fiss_reg PF05308.6 ESS64632.1 - 0.13 11.6 9.3 0.29 10.4 4.4 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.14 ESS64632.1 - 0.18 11.0 3.3 0.35 10.1 2.3 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MSP1_C PF07462.6 ESS64632.1 - 1.7 6.8 8.7 2.8 6.2 6.0 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Tmemb_40 PF10160.4 ESS64633.1 - 0.0067 15.6 1.6 0.0099 15.1 1.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein Mucin PF01456.12 ESS64633.1 - 7.1 6.3 10.4 0.64 9.7 0.7 2.8 3 0 0 3 3 3 0 Mucin-like glycoprotein Cyclin PF08613.6 ESS64634.1 - 2.3e-18 67.0 0.1 4.1e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESS64634.1 - 6.6e-07 28.9 0.1 1.2e-06 28.0 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 ESS64635.1 - 1.1e-21 77.7 0.1 1.9e-21 77.0 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESS64635.1 - 9.7e-08 31.6 0.1 1.9e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain WD40 PF00400.27 ESS64636.1 - 1.2e-35 120.0 24.8 1.7e-06 27.6 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat PFU PF09070.6 ESS64636.1 - 1.7e-34 118.3 0.2 3.4e-34 117.3 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) Cep57_CLD PF14073.1 ESS64637.1 - 1.6e-05 24.8 8.0 2.3e-05 24.3 5.5 1.3 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 Activator_LAG-3 PF11498.3 ESS64637.1 - 0.018 13.8 7.5 0.021 13.5 5.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF342 PF03961.8 ESS64637.1 - 0.13 10.6 6.3 0.17 10.2 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CENP-H PF05837.7 ESS64637.1 - 0.31 11.2 7.4 0.68 10.1 5.1 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Fmp27_WPPW PF10359.4 ESS64637.1 - 0.58 8.5 8.8 0.73 8.1 6.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain TMPIT PF07851.8 ESS64637.1 - 1.4 7.9 5.9 1.9 7.4 4.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein Macoilin PF09726.4 ESS64637.1 - 4.4 5.4 18.6 16 3.6 13.0 1.5 1 1 1 2 2 2 0 Transmembrane protein Ins134_P3_kin PF05770.6 ESS64638.1 - 2.8e-06 26.5 2.5 0.067 12.1 0.6 3.7 3 1 0 3 3 3 2 Inositol 1, 3, 4-trisphosphate 5/6-kinase DUF1840 PF08895.6 ESS64639.1 - 2.8 8.0 6.4 0.2 11.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Scaffolding_pro PF11418.3 ESS64640.1 - 1 9.7 13.3 0.15 12.4 0.9 4.4 3 2 1 4 4 4 0 Phi29 scaffolding protein Reo_sigmaC PF04582.7 ESS64640.1 - 2.7 7.0 5.1 7.1 5.7 0.6 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 ESS64640.1 - 2.9 8.1 5.0 2e+02 2.3 0.2 4.8 3 3 2 5 5 5 0 Nucleopolyhedrovirus P10 protein STOP PF05217.7 ESS64642.1 - 4e-11 43.0 16.4 0.0011 18.7 6.7 3.9 1 1 2 4 4 4 4 STOP protein DUF1682 PF07946.9 ESS64643.1 - 0.037 12.8 9.7 0.057 12.2 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) PCIF1_WW PF12237.3 ESS64644.1 - 1.7e-08 33.9 0.0 4e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain PI3_PI4_kinase PF00454.22 ESS64645.1 - 5.6e-46 156.9 0.0 5.2e-30 104.6 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 ESS64645.1 - 1e-35 122.5 1.7 1.9e-35 121.7 1.2 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.19 ESS64645.1 - 1e-08 35.0 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 TFCD_C PF12612.3 ESS64646.1 - 3.7e-38 130.8 3.1 5.1e-38 130.4 0.5 2.5 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.1 ESS64646.1 - 6.7e-08 32.7 12.5 0.037 14.3 0.2 7.5 7 1 1 8 8 8 3 HEAT repeats HEAT PF02985.17 ESS64646.1 - 0.00012 21.8 27.1 0.04 13.9 0.0 9.8 10 0 0 10 10 10 2 HEAT repeat HEAT_EZ PF13513.1 ESS64646.1 - 0.00024 21.5 33.3 0.71 10.4 0.4 10.6 10 1 1 11 11 11 3 HEAT-like repeat DUF2454 PF10521.4 ESS64646.1 - 0.16 10.9 0.0 0.64 8.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) Transketolase_N PF00456.16 ESS64647.1 - 1.4e-136 454.7 0.0 1.9e-136 454.2 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 ESS64647.1 - 8.5e-44 149.1 0.0 1.4e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESS64647.1 - 8.9e-08 32.1 0.0 2e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Terpene_synth PF01397.16 ESS64647.1 - 0.014 14.8 0.3 0.027 13.8 0.0 1.6 2 0 0 2 2 2 0 Terpene synthase, N-terminal domain DXP_synthase_N PF13292.1 ESS64647.1 - 0.022 13.7 0.0 0.6 8.9 0.0 2.4 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Ribosomal_S8e PF01201.17 ESS64648.1 - 6.3e-43 146.0 3.6 7.7e-43 145.8 2.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Kelch_3 PF13415.1 ESS64649.1 - 1.3e-49 165.3 6.5 1e-10 41.4 0.0 7.3 7 0 0 7 7 7 7 Galactose oxidase, central domain Kelch_4 PF13418.1 ESS64649.1 - 2.2e-47 158.5 9.1 5.9e-08 32.3 0.4 6.9 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS64649.1 - 1.1e-34 117.8 7.0 2.4e-06 27.3 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 ESS64649.1 - 2e-33 113.6 15.3 1.9e-07 30.5 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 ESS64649.1 - 5.4e-30 102.3 10.0 3.2e-06 27.0 0.0 6.2 4 2 2 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESS64649.1 - 4.4e-25 86.4 13.0 4.3e-06 26.2 0.1 6.9 6 2 0 6 6 6 5 Kelch motif Rax2 PF12768.2 ESS64649.1 - 0.00088 18.5 0.0 0.027 13.7 0.0 2.8 2 2 1 3 3 3 1 Cortical protein marker for cell polarity DUF1509 PF07420.6 ESS64650.1 - 0.044 13.0 0.3 0.062 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) SRPRB PF09439.5 ESS64652.1 - 1.8e-25 89.2 0.4 1.2e-16 60.4 0.1 2.2 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 ESS64652.1 - 4e-10 39.4 0.0 4.8e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESS64652.1 - 3.4e-06 26.9 0.0 5.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 ESS64652.1 - 5.4e-06 25.7 0.0 0.02 14.1 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 ESS64652.1 - 0.0018 18.7 0.0 0.0034 17.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein DUF2855 PF11017.3 ESS64652.1 - 0.0054 15.9 0.4 0.0068 15.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) DUF463 PF04317.7 ESS64652.1 - 0.0082 14.7 0.3 2.2 6.7 0.0 2.1 2 0 0 2 2 2 2 YcjX-like family, DUF463 Mg_chelatase PF01078.16 ESS64652.1 - 0.013 14.6 0.1 0.026 13.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Septin PF00735.13 ESS64652.1 - 0.024 13.6 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_16 PF13191.1 ESS64652.1 - 0.034 14.1 1.9 0.17 11.8 1.3 2.0 1 1 0 1 1 1 0 AAA ATPase domain Arch_ATPase PF01637.13 ESS64652.1 - 0.043 13.5 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase DUF4445 PF14574.1 ESS64652.1 - 0.045 11.9 0.0 0.07 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4445) AAA_33 PF13671.1 ESS64652.1 - 0.049 13.4 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 ESS64652.1 - 0.053 13.0 0.2 0.96 8.9 0.0 2.3 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.12 ESS64652.1 - 0.054 12.9 0.1 0.58 9.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.7 ESS64652.1 - 0.054 13.1 1.1 0.59 9.7 0.8 2.1 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 ESS64652.1 - 0.059 13.5 0.1 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain NAD_binding_3 PF03447.11 ESS64652.1 - 0.089 13.1 0.7 0.47 10.8 0.2 2.1 1 1 1 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Gtr1_RagA PF04670.7 ESS64652.1 - 0.089 11.9 0.0 0.15 11.1 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Sigma54_activat PF00158.21 ESS64652.1 - 0.11 12.0 0.2 8.8 5.7 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain cobW PF02492.14 ESS64652.1 - 0.19 11.1 1.5 0.75 9.2 0.1 2.1 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 ESS64652.1 - 0.19 11.2 1.4 1.2 8.6 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein WD40 PF00400.27 ESS64653.1 - 1.2e-09 37.6 0.5 0.1 12.5 0.0 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat CENP-B_dimeris PF09026.5 ESS64653.1 - 0.034 14.3 3.1 0.095 12.9 2.2 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SARG PF15385.1 ESS64654.1 - 2 7.6 11.3 2.3 7.4 7.8 1.1 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein ThiF PF00899.16 ESS64655.1 - 0.001 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 ThiF family DUF4129 PF13559.1 ESS64655.1 - 0.23 11.4 3.3 1.7 8.6 0.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4129) zf-CCHC_4 PF14392.1 ESS64656.1 - 0.15 11.7 6.4 0.51 10.0 1.0 2.8 2 0 0 2 2 2 0 Zinc knuckle PyrI_C PF02748.10 ESS64656.1 - 0.3 10.5 1.7 12 5.3 0.1 2.9 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CCHC PF00098.18 ESS64656.1 - 1.2 9.2 10.5 7.5 6.6 1.2 3.0 2 0 0 2 2 2 0 Zinc knuckle SR-25 PF10500.4 ESS64656.1 - 2.1 7.7 5.4 4.3 6.7 3.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GRAB PF10375.4 ESS64657.1 - 0.00049 19.6 0.0 0.0013 18.3 0.0 1.7 1 0 0 1 1 1 1 GRIP-related Arf-binding domain TMF_DNA_bd PF12329.3 ESS64657.1 - 0.0098 15.6 6.2 0.0098 15.6 4.3 10.8 6 4 3 10 10 10 3 TATA element modulatory factor 1 DNA binding Reo_sigmaC PF04582.7 ESS64657.1 - 0.68 9.0 25.7 0.29 10.2 3.8 4.4 3 1 1 4 4 4 0 Reovirus sigma C capsid protein MCM PF00493.18 ESS64659.1 - 6.3e-116 386.7 0.0 9.3e-116 386.2 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESS64659.1 - 1e-16 61.5 0.0 3.2e-16 59.9 0.0 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESS64659.1 - 6.5e-09 35.2 0.0 2.2e-07 30.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESS64659.1 - 4.2e-05 23.0 0.0 0.00034 20.1 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.6 ESS64659.1 - 0.00019 21.0 0.0 0.00048 19.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESS64659.1 - 0.0085 15.8 0.0 0.033 13.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ketoacyl-synt PF00109.21 ESS64660.1 - 1.8e-44 152.1 0.1 2.6e-44 151.6 0.1 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 ESS64660.1 - 4.8e-27 94.1 0.1 7.4e-27 93.5 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 ESS64660.1 - 0.007 15.3 0.2 0.011 14.6 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain RRM_6 PF14259.1 ESS64662.1 - 3.5e-42 142.2 0.0 7.5e-16 57.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS64662.1 - 8.6e-30 102.1 0.0 1.4e-11 43.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS64662.1 - 1e-06 28.5 0.0 0.009 15.8 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup54 PF13874.1 ESS64662.1 - 0.015 14.9 0.9 0.51 9.9 1.3 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 SYF2 PF08231.7 ESS64663.1 - 7.3 6.7 22.4 9.7 6.2 15.5 1.2 1 0 0 1 1 1 0 SYF2 splicing factor GTP_EFTU PF00009.22 ESS64665.1 - 2.8e-35 121.4 1.6 3e-35 121.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 ESS64665.1 - 6.3e-15 54.9 0.0 1.5e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 ESS64665.1 - 4.1e-13 49.2 0.9 2.5e-07 30.7 0.0 3.8 4 0 0 4 4 4 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESS64665.1 - 1.1e-06 28.5 0.0 3.1e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase MIP-T3 PF10243.4 ESS64665.1 - 0.0003 19.4 28.5 0.0003 19.4 19.7 1.8 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 GTP_EFTU_D4 PF14578.1 ESS64665.1 - 0.00056 19.5 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 AAA_16 PF13191.1 ESS64665.1 - 0.0094 15.9 0.1 0.0094 15.9 0.1 2.7 3 1 0 3 3 3 1 AAA ATPase domain Miro PF08477.8 ESS64665.1 - 0.013 15.9 0.0 0.069 13.6 0.0 2.4 1 0 0 1 1 1 0 Miro-like protein ATP_bind_1 PF03029.12 ESS64665.1 - 0.015 14.8 0.0 0.051 13.1 0.0 1.9 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 ESS64665.1 - 0.038 14.1 0.1 0.39 10.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain Ras PF00071.17 ESS64665.1 - 0.053 12.9 0.0 0.25 10.7 0.0 2.2 1 1 0 1 1 1 0 Ras family She9_MDM33 PF05546.6 ESS64666.1 - 0.0024 17.4 8.0 0.0024 17.4 5.6 1.8 1 1 0 1 1 1 1 She9 / Mdm33 family TMCO5 PF14992.1 ESS64666.1 - 0.0025 16.9 9.7 0.0041 16.3 6.7 1.3 1 0 0 1 1 1 1 TMCO5 family RTBV_P46 PF06216.6 ESS64666.1 - 0.082 11.7 4.4 0.11 11.3 3.1 1.1 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein DegT_DnrJ_EryC1 PF01041.12 ESS64666.1 - 0.12 11.3 1.0 0.15 11.0 0.7 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family AAA_13 PF13166.1 ESS64666.1 - 0.31 9.4 7.4 0.42 9.0 5.1 1.3 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.14 ESS64666.1 - 0.61 7.8 7.9 0.74 7.5 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hom_end_hint PF05203.11 ESS64666.1 - 0.66 9.6 2.5 0.76 9.4 1.8 1.2 1 0 0 1 1 1 0 Hom_end-associated Hint His_kinase PF06580.8 ESS64666.1 - 0.72 9.8 5.0 1.7 8.6 1.7 2.3 1 1 1 2 2 2 0 Histidine kinase Mit_ribos_Mrp51 PF11709.3 ESS64666.1 - 0.97 8.5 3.3 5.4 6.1 2.9 1.8 1 1 1 2 2 2 0 Mitochondrial ribosomal protein subunit FliJ PF02050.11 ESS64666.1 - 1.5 8.9 19.8 2.1 8.4 13.8 1.2 1 0 0 1 1 1 0 Flagellar FliJ protein CFIA_Pcf11 PF11526.3 ESS64666.1 - 1.5 9.0 4.7 35 4.6 3.2 2.3 1 1 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 Atg14 PF10186.4 ESS64666.1 - 1.5 7.6 20.9 1.6 7.6 13.2 1.6 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TPR_MLP1_2 PF07926.7 ESS64666.1 - 1.7 8.4 20.2 5.1 6.8 12.5 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DivIVA PF05103.8 ESS64666.1 - 2.9 7.9 15.6 0.25 11.4 6.1 2.0 1 1 1 2 2 2 0 DivIVA protein Spore_II_R PF09551.5 ESS64666.1 - 4.3 7.3 6.1 3.6 7.6 2.6 1.8 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) TMF_DNA_bd PF12329.3 ESS64666.1 - 4.6 7.1 18.0 2.3 8.0 9.7 2.2 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.6 ESS64666.1 - 5.1 5.6 18.2 7.8 5.0 12.0 1.5 1 1 1 2 2 2 0 Spc7 kinetochore protein FlgN PF05130.7 ESS64666.1 - 6.2 7.0 20.3 9.1 6.5 14.1 1.3 1 0 0 1 1 1 0 FlgN protein Phage_GP20 PF06810.6 ESS64666.1 - 8.9 5.7 15.1 8.5 5.8 6.9 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4520 PF15016.1 ESS64667.1 - 2.1e-28 97.6 0.4 6.6e-27 92.9 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4520) Laminin_G_3 PF13385.1 ESS64670.1 - 2e-06 28.1 0.0 3.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Beach PF02138.13 ESS64671.1 - 3.2e-96 321.9 0.7 9.4e-95 317.1 0.0 2.9 3 0 0 3 3 3 1 Beige/BEACH domain WD40 PF00400.27 ESS64671.1 - 0.12 12.3 2.5 4.4 7.3 0.0 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat GTP_EFTU PF00009.22 ESS64672.1 - 2.1e-23 82.7 0.0 5.2e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESS64672.1 - 5.1e-14 52.2 0.6 1.3e-13 50.9 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESS64672.1 - 1.8e-07 31.1 0.1 1.8e-07 31.1 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESS64672.1 - 0.0068 16.3 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ESS64672.1 - 0.02 14.3 0.3 2.8 7.4 0.0 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 ESS64672.1 - 0.04 13.6 0.0 0.14 11.8 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TFIIS_C PF01096.13 ESS64673.1 - 5.7e-17 61.0 7.2 1.1e-16 60.1 5.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) PWWP PF00855.12 ESS64673.1 - 1.2e-10 41.4 0.0 2.5e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 PWWP domain Med26 PF08711.6 ESS64673.1 - 3.7e-05 23.1 0.1 8.5e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Sgf11 PF08209.6 ESS64673.1 - 0.71 9.2 3.7 3.1 7.2 0.2 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) TFIIS_C PF01096.13 ESS64675.1 - 8.1e-05 22.1 1.6 0.00013 21.5 0.5 1.9 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 ESS64675.1 - 0.00033 20.1 0.0 0.00059 19.2 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zinc_ribbon_5 PF13719.1 ESS64675.1 - 0.014 14.9 1.0 0.072 12.6 0.7 2.2 1 1 0 1 1 1 0 zinc-ribbon domain Lar_restr_allev PF14354.1 ESS64675.1 - 0.023 14.9 0.4 0.053 13.8 0.2 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-DNL PF05180.7 ESS64675.1 - 0.05 13.3 0.9 0.14 11.8 0.2 2.1 2 0 0 2 2 2 0 DNL zinc finger zinc_ribbon_4 PF13717.1 ESS64675.1 - 0.051 13.2 1.0 0.29 10.8 0.7 2.2 1 1 0 1 1 1 0 zinc-ribbon domain CHAP PF05257.11 ESS64676.1 - 4.3e-19 68.3 0.0 8.4e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 CHAP domain FixP_N PF14715.1 ESS64676.1 - 0.071 12.5 0.2 0.19 11.1 0.1 1.7 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP ATG27 PF09451.5 ESS64676.1 - 0.087 12.0 0.1 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 CHAP PF05257.11 ESS64677.1 - 1.4e-07 31.1 2.1 8.9e-07 28.6 1.5 2.2 1 1 0 1 1 1 1 CHAP domain Amidase_6 PF12671.2 ESS64677.1 - 0.02 14.9 0.5 0.058 13.4 0.1 1.8 1 1 1 2 2 2 0 Putative amidase domain Beta_helix PF13229.1 ESS64682.1 - 3.1e-05 23.7 0.8 0.017 14.8 0.0 4.3 3 1 0 3 3 3 1 Right handed beta helix region hEGF PF12661.2 ESS64682.1 - 0.55 10.4 7.0 0.44 10.7 1.4 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF UQ_con PF00179.21 ESS64684.1 - 2e-34 118.0 0.0 2.8e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DnaJ PF00226.26 ESS64687.1 - 1.3e-15 56.8 0.1 1.3e-15 56.8 0.1 2.0 2 0 0 2 2 2 1 DnaJ domain Carboxyl_trans PF01039.17 ESS64687.1 - 0.55 8.5 3.0 0.68 8.2 2.1 1.1 1 0 0 1 1 1 0 Carboxyl transferase domain DUF1690 PF07956.6 ESS64687.1 - 0.96 9.4 7.4 1.4 8.8 5.1 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) CBP4 PF07960.6 ESS64687.1 - 4.5 6.9 9.4 0.73 9.4 3.7 1.7 2 0 0 2 2 2 0 CBP4 KRTDAP PF15200.1 ESS64688.1 - 0.016 14.9 0.0 0.043 13.5 0.0 1.7 1 0 0 1 1 1 0 Keratinocyte differentiation-associated zf-Sec23_Sec24 PF04810.10 ESS64688.1 - 0.059 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger MRC1 PF09444.5 ESS64688.1 - 9.3 6.5 19.5 0.059 13.6 3.5 3.1 3 0 0 3 3 3 0 MRC1-like domain DUF4457 PF14652.1 ESS64690.1 - 6.9e-30 104.1 0.0 2e-10 40.1 0.0 4.3 3 1 0 4 4 4 4 Domain of unknown function (DUF4457) TRAM_LAG1_CLN8 PF03798.11 ESS64691.1 - 5.6e-21 75.0 15.8 5.6e-21 75.0 10.9 1.4 2 0 0 2 2 2 1 TLC domain HEAT_2 PF13646.1 ESS64692.1 - 8.9e-30 102.8 4.8 5.8e-16 58.5 0.7 3.2 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 ESS64692.1 - 7e-22 75.6 0.8 0.00019 21.5 0.1 6.1 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.17 ESS64692.1 - 1.4e-05 24.7 2.3 0.014 15.4 0.0 4.4 5 1 1 6 6 6 1 HEAT repeat HEAT_EZ PF13513.1 ESS64692.1 - 7.5e-05 23.0 3.7 0.0017 18.7 0.5 3.6 3 2 1 4 4 4 1 HEAT-like repeat Vitellogenin_N PF01347.17 ESS64692.1 - 0.022 12.9 0.0 0.04 12.1 0.0 1.5 1 1 0 1 1 1 0 Lipoprotein amino terminal region HEAT PF02985.17 ESS64694.1 - 0.083 13.0 0.0 0.32 11.2 0.0 2.1 1 0 0 1 1 1 0 HEAT repeat Sedlin_N PF04628.8 ESS64695.1 - 7.2e-08 32.3 0.0 1.5e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region DUF2630 PF10944.3 ESS64695.1 - 0.13 12.4 0.1 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) DUF4460 PF14687.1 ESS64696.1 - 4.9e-09 35.9 0.1 1.2e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF4461 PF14688.1 ESS64696.1 - 6.7e-06 25.6 0.0 0.069 12.4 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4461) LRR_6 PF13516.1 ESS64697.1 - 0.00018 21.2 3.7 15 6.0 0.1 6.2 7 0 0 7 7 7 1 Leucine Rich repeat LRR_4 PF12799.2 ESS64697.1 - 0.00024 20.6 0.3 0.16 11.6 0.3 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS64697.1 - 0.0092 15.8 7.8 12 6.4 0.1 6.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.1 ESS64697.1 - 0.93 9.2 4.1 6 6.7 0.2 3.3 3 0 0 3 3 3 0 Leucine rich repeat LRR_7 PF13504.1 ESS64697.1 - 1.5 9.3 8.3 83 4.0 0.1 5.5 5 0 0 5 5 5 0 Leucine rich repeat ELMO_CED12 PF04727.8 ESS64699.1 - 3.8e-45 153.4 0.1 6.4e-45 152.7 0.1 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family Methyltransf_18 PF12847.2 ESS64700.1 - 0.014 15.9 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ESS64700.1 - 0.17 11.5 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain EB1 PF03271.12 ESS64703.1 - 1.2e-10 41.2 0.1 2.1e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif zf-C2H2_4 PF13894.1 ESS64704.1 - 5.2e-08 32.6 35.6 0.0015 18.7 1.6 5.7 5 1 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESS64704.1 - 1.6e-07 31.2 1.7 1.6e-07 31.2 1.2 6.2 6 1 1 7 7 7 1 Zinc-finger double domain zf-BED PF02892.10 ESS64704.1 - 0.0034 17.1 15.7 1.2 8.9 0.5 4.6 3 1 1 4 4 4 3 BED zinc finger zf-met2 PF12907.2 ESS64704.1 - 0.033 14.1 1.8 3 7.8 0.1 2.9 2 0 0 2 2 2 0 Zinc-binding zf-TRAF PF02176.13 ESS64704.1 - 0.35 11.2 18.9 0.35 11.2 0.9 4.1 4 1 1 5 5 5 0 TRAF-type zinc finger TF_Zn_Ribbon PF08271.7 ESS64704.1 - 1.5 8.2 0.0 1.5 8.2 0.0 3.1 4 0 0 4 4 4 0 TFIIB zinc-binding Elf1 PF05129.8 ESS64704.1 - 1.9 8.2 9.4 18 5.1 0.3 3.5 3 1 0 3 3 3 0 Transcription elongation factor Elf1 like RNHCP PF12647.2 ESS64704.1 - 3.1 7.6 12.1 1.2 9.0 0.4 3.7 3 1 0 3 3 3 0 RNHCP domain DNA_binding_1 PF01035.15 ESS64705.1 - 2.3e-26 91.3 0.1 3.7e-26 90.6 0.1 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain MGC-24 PF05283.6 ESS64705.1 - 0.23 11.2 2.0 0.33 10.7 0.7 1.7 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24) Cnd1 PF12717.2 ESS64706.1 - 5.8e-06 26.2 0.0 1.3e-05 25.0 0.0 1.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 ESS64706.1 - 0.00018 21.2 0.9 0.12 12.5 0.0 3.0 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 ESS64706.1 - 0.00021 21.5 0.5 0.0017 18.6 0.1 2.1 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.1 ESS64706.1 - 0.0036 17.7 2.1 0.12 12.8 0.4 3.1 1 1 2 3 3 3 1 HEAT-like repeat SpecificRecomb PF10136.4 ESS64706.1 - 0.019 13.0 0.1 0.023 12.7 0.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase PNP_UDP_1 PF01048.15 ESS64706.1 - 0.043 12.7 0.0 0.055 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphorylase superfamily Adaptin_N PF01602.15 ESS64706.1 - 0.045 12.0 0.1 0.057 11.7 0.1 1.1 1 0 0 1 1 1 0 Adaptin N terminal region Peptidase_M8 PF01457.11 ESS64709.1 - 9.5e-124 413.5 0.0 1.3e-123 413.1 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin BRCA2 PF00634.13 ESS64710.1 - 0.0019 17.4 0.0 0.0045 16.2 0.0 1.7 1 0 0 1 1 1 1 BRCA2 repeat DUF2220 PF09983.4 ESS64711.1 - 0.31 10.1 8.6 0.1 11.7 1.5 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Ribosomal_S27 PF01599.14 ESS64711.1 - 0.83 9.5 4.8 0.31 10.8 0.4 2.3 2 0 0 2 2 2 0 Ribosomal protein S27a TPR_14 PF13428.1 ESS64712.1 - 0.058 14.0 3.2 19 6.2 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS64712.1 - 0.3 11.0 2.1 34 4.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESS64713.1 - 8.7e-59 198.7 0.0 1.9e-58 197.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64713.1 - 3.9e-39 134.2 0.0 6.6e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.19 ESS64713.1 - 1.6e-06 27.8 0.0 4.5e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold Kinase-like PF14531.1 ESS64713.1 - 0.00013 21.0 0.0 0.038 12.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 ESS64713.1 - 0.008 15.2 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS64713.1 - 0.017 14.8 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4577 PF15145.1 ESS64713.1 - 0.18 11.7 2.5 10 6.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) TerD PF02342.13 ESS64714.1 - 0.0058 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 TerD domain DUF4611 PF15387.1 ESS64714.1 - 0.049 13.7 0.8 0.12 12.5 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_viral_N PF00242.12 ESS64715.1 - 1.4 7.8 15.2 1.5 7.7 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain MIP-T3 PF10243.4 ESS64715.1 - 9.3 4.5 25.0 11 4.3 17.3 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 FA_desaturase PF00487.19 ESS64716.1 - 5.6e-26 91.5 18.6 9.6e-26 90.7 12.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.5 ESS64716.1 - 1.8e-18 65.4 0.7 3.1e-18 64.7 0.5 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Lant_dehyd_N PF04737.8 ESS64716.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus RNase_H PF00075.19 ESS64718.1 - 6.2e-08 33.0 0.0 9.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_jaz PF12171.3 ESS64718.1 - 0.03 14.4 2.3 3.3 7.9 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS64718.1 - 1.2 9.5 14.3 1.9 8.9 0.6 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS64718.1 - 1.4 9.3 16.4 1.5 9.2 1.7 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type BCIP PF13862.1 ESS64719.1 - 2e-28 99.2 0.0 2.5e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DnaJ PF00226.26 ESS64720.1 - 5e-08 32.5 0.0 9.3e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain OrfB_Zn_ribbon PF07282.6 ESS64720.1 - 0.32 10.6 4.3 0.48 10.1 2.3 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain CAP_N PF01213.14 ESS64720.1 - 0.78 8.9 5.5 1.8 7.7 3.8 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF663 PF04950.7 ESS64721.1 - 5.8e-78 261.8 0.0 5.8e-78 261.8 0.0 1.7 2 0 0 2 2 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 ESS64721.1 - 5.3e-25 86.7 0.1 2.2e-24 84.8 0.0 2.2 2 0 0 2 2 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.1 ESS64721.1 - 6.7e-05 23.0 0.0 0.00018 21.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS64721.1 - 0.0001 22.3 0.0 0.00033 20.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.18 ESS64721.1 - 0.00019 21.3 0.0 0.00053 19.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase MobB PF03205.9 ESS64721.1 - 0.0002 21.1 0.4 0.00061 19.5 0.0 2.0 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.22 ESS64721.1 - 0.00084 18.8 0.0 0.028 13.8 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_30 PF13604.1 ESS64721.1 - 0.0017 17.9 0.8 0.0064 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 ESS64721.1 - 0.0021 18.3 0.0 0.013 15.7 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_10 PF12846.2 ESS64721.1 - 0.0028 17.1 0.0 0.0061 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA-like domain AAA_33 PF13671.1 ESS64721.1 - 0.0033 17.2 0.0 0.016 15.0 0.0 2.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS64721.1 - 0.0035 17.0 0.0 0.0078 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Miro PF08477.8 ESS64721.1 - 0.0054 17.2 0.0 0.016 15.6 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein AAA_17 PF13207.1 ESS64721.1 - 0.006 17.4 2.4 0.016 16.0 0.0 3.1 3 0 0 3 3 1 1 AAA domain ATP_bind_1 PF03029.12 ESS64721.1 - 0.013 15.0 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.10 ESS64721.1 - 0.017 14.8 0.1 0.037 13.7 0.1 1.6 1 0 0 1 1 1 0 NTPase DUF258 PF03193.11 ESS64721.1 - 0.018 14.2 0.0 0.04 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA PF00004.24 ESS64721.1 - 0.019 15.1 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESS64721.1 - 0.038 13.7 0.2 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 ESS64721.1 - 0.059 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain PDGLE PF13190.1 ESS64721.1 - 0.39 10.4 0.8 1.6 8.4 0.1 2.3 2 0 0 2 2 2 0 PDGLE domain AAA_23 PF13476.1 ESS64721.1 - 1.1 9.5 8.0 14 5.9 0.5 3.5 3 1 1 4 4 4 0 AAA domain Methyltransf_16 PF10294.4 ESS64723.1 - 7.3e-15 54.8 0.0 1e-13 51.1 0.0 2.5 2 1 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESS64723.1 - 0.061 13.9 0.0 0.13 12.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF4586 PF15239.1 ESS64724.1 - 2.9e-10 40.1 0.1 3.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Kinesin PF00225.18 ESS64725.1 - 1.1e-91 307.0 0.5 1.8e-91 306.3 0.4 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF1635 PF07795.6 ESS64725.1 - 3 7.1 10.2 5.5 6.2 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF1323 PF07037.6 ESS64725.1 - 8.2 6.6 8.8 4.4 7.4 2.6 2.7 3 0 0 3 3 3 0 Putative transcription regulator (DUF1323) Rep_fac-A_C PF08646.5 ESS64726.1 - 1.9e-43 147.6 1.1 2e-40 137.8 0.1 3.1 3 0 0 3 3 3 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 ESS64726.1 - 9e-13 47.8 0.0 9.4e-11 41.4 0.0 2.5 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain DZR PF12773.2 ESS64726.1 - 0.014 15.1 1.9 0.028 14.2 1.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 ESS64726.1 - 0.08 12.7 1.6 0.16 11.7 1.1 1.5 1 0 0 1 1 1 0 zinc-ribbons PhnA_Zn_Ribbon PF08274.7 ESS64726.1 - 0.11 12.3 0.5 0.21 11.4 0.4 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon Zn_Tnp_IS1595 PF12760.2 ESS64726.1 - 0.23 11.2 4.1 0.43 10.4 2.8 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain AAA PF00004.24 ESS64729.1 - 1.1e-32 113.0 0.0 1.7e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESS64729.1 - 2.5e-07 31.0 0.0 4.5e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS64729.1 - 1.2e-06 29.3 0.0 2.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS64729.1 - 1.4e-06 28.4 0.0 1.1e-05 25.6 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESS64729.1 - 3.3e-06 27.2 0.0 6.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.1 ESS64729.1 - 7.1e-05 22.4 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESS64729.1 - 0.00013 21.4 0.7 0.0099 15.3 0.0 2.5 2 1 1 3 3 2 1 AAA domain Arch_ATPase PF01637.13 ESS64729.1 - 0.00014 21.6 0.1 0.028 14.1 0.1 2.2 1 1 0 1 1 1 1 Archaeal ATPase DUF815 PF05673.8 ESS64729.1 - 0.00052 19.0 0.0 0.012 14.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.1 ESS64729.1 - 0.00099 18.9 0.0 0.0023 17.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESS64729.1 - 0.001 19.2 0.0 0.0019 18.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.1 ESS64729.1 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESS64729.1 - 0.0015 18.2 0.0 0.0036 16.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Sigma54_activ_2 PF14532.1 ESS64729.1 - 0.002 18.1 0.0 0.0052 16.8 0.0 1.6 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.9 ESS64729.1 - 0.0021 17.8 0.1 0.0055 16.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS64729.1 - 0.0023 17.6 0.0 0.0059 16.3 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 ESS64729.1 - 0.0026 16.8 0.0 0.0051 15.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 ESS64729.1 - 0.0033 16.8 0.0 0.014 14.7 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_28 PF13521.1 ESS64729.1 - 0.0035 17.3 0.0 0.011 15.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 ESS64729.1 - 0.0037 16.8 0.0 0.0066 16.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 TIP49 PF06068.8 ESS64729.1 - 0.0095 14.6 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus KAP_NTPase PF07693.9 ESS64729.1 - 0.021 13.8 0.0 0.16 10.9 0.0 1.9 1 1 1 2 2 2 0 KAP family P-loop domain AAA_2 PF07724.9 ESS64729.1 - 0.036 13.9 0.0 0.077 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 ESS64729.1 - 0.038 13.1 0.0 0.074 12.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 ESS64729.1 - 0.065 12.3 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.1 ESS64729.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 ESS64729.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SKI PF01202.17 ESS64729.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase PduV-EutP PF10662.4 ESS64729.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.10 ESS64729.1 - 0.11 11.2 0.0 0.16 10.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ABC_tran PF00005.22 ESS64729.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 ESS64729.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 ESS64729.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 ESS64729.1 - 0.17 11.4 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESS64729.1 - 0.18 11.4 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF4131 PF13567.1 ESS64729.1 - 5.5 6.3 10.2 1.7 8.0 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Topoisom_bac PF01131.15 ESS64730.1 - 1.6e-95 320.3 0.0 2.1e-95 319.9 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 ESS64730.1 - 5.1e-14 52.0 0.0 9.3e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 Toprim domain zf-BED PF02892.10 ESS64730.1 - 1.9 8.2 8.6 10 5.9 0.1 3.9 4 0 0 4 4 4 0 BED zinc finger ArfGap PF01412.13 ESS64731.1 - 1.5e-38 131.1 0.8 1.3e-37 128.1 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf DUF1183 PF06682.7 ESS64731.1 - 0.2 11.2 5.0 0.27 10.8 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) WD40 PF00400.27 ESS64732.1 - 9.9e-05 22.0 3.1 0.00025 20.8 0.1 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat PQQ_2 PF13360.1 ESS64732.1 - 0.018 14.4 0.2 0.54 9.6 0.1 2.6 1 1 0 2 2 2 0 PQQ-like domain PQQ PF01011.16 ESS64732.1 - 0.037 13.5 0.0 1 8.9 0.0 2.5 2 0 0 2 2 2 0 PQQ enzyme repeat DUF3050 PF11251.3 ESS64732.1 - 0.16 11.1 0.0 0.36 10.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3050) Methyltransf_18 PF12847.2 ESS64733.1 - 0.0028 18.2 0.0 0.005 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.6 ESS64733.1 - 0.092 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Nol1_Nop2_Fmu PF01189.12 ESS64734.1 - 4.8e-22 78.6 0.0 2.1e-13 50.2 0.0 2.8 2 1 1 3 3 3 2 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 ESS64734.1 - 0.02 14.9 0.2 0.055 13.5 0.1 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 ESS64734.1 - 0.034 14.7 0.1 0.21 12.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain PC_rep PF01851.17 ESS64735.1 - 7.7e-22 76.2 12.3 0.0004 20.4 0.0 7.9 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.1 ESS64735.1 - 3.1e-12 46.6 0.0 2.9e-07 30.6 0.0 5.4 3 1 3 6 6 6 4 HEAT repeats HEAT PF02985.17 ESS64735.1 - 0.0046 16.9 0.8 24 5.3 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat DUF466 PF04328.8 ESS64737.1 - 0.0066 16.2 0.6 0.015 15.1 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF466) zf-HIT PF04438.11 ESS64741.1 - 0.045 13.3 7.1 0.11 12.1 4.9 1.7 1 0 0 1 1 1 0 HIT zinc finger zf-B_box PF00643.19 ESS64741.1 - 0.13 12.1 1.5 0.33 10.8 1.0 1.7 1 0 0 1 1 1 0 B-box zinc finger Pkinase PF00069.20 ESS64742.1 - 6.5e-64 215.5 0.0 1.1e-63 214.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64742.1 - 1.3e-33 116.1 0.0 2.1e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Lipocalin_5 PF13924.1 ESS64742.1 - 1.4e-31 109.0 0.0 2.6e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Lipocalin-like domain PX PF00787.19 ESS64742.1 - 2.7e-12 46.4 0.8 6.3e-12 45.2 0.5 1.6 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.1 ESS64742.1 - 1.4e-07 30.7 0.0 2.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FYVE PF01363.16 ESS64742.1 - 3.1e-05 23.7 9.1 9.4e-05 22.2 6.3 1.8 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.18 ESS64742.1 - 0.025 14.3 0.2 0.088 12.5 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESS64744.1 - 5.1e-07 29.1 0.1 0.015 14.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64744.1 - 0.00051 19.1 0.1 0.073 12.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DUF3342 PF11822.3 ESS64746.1 - 1.7e-118 395.3 0.1 2.3e-118 394.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) TruD PF01142.13 ESS64747.1 - 1.2e-41 142.6 0.0 1.1e-39 136.2 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) CT47 PF15623.1 ESS64747.1 - 0.029 14.1 3.9 0.054 13.2 2.7 1.4 1 0 0 1 1 1 0 Cancer/testis gene family 47 Helicase_C_2 PF13307.1 ESS64749.1 - 1.6e-43 148.5 0.2 5.7e-43 146.7 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESS64749.1 - 7.8e-36 123.0 0.1 1.3e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 ESS64749.1 - 0.00013 21.4 0.0 0.21 11.0 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESS64749.1 - 0.0018 18.1 0.0 2.8 7.7 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Kelch_3 PF13415.1 ESS64750.1 - 7.8e-22 76.8 0.6 2.1e-08 34.0 0.0 4.0 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS64750.1 - 8.1e-14 51.2 0.4 1.9e-08 34.0 0.0 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.1 ESS64750.1 - 2.8e-11 42.9 0.9 2.1e-06 27.3 0.0 4.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESS64750.1 - 6.8e-08 32.3 1.3 0.12 12.5 0.0 4.7 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.20 ESS64750.1 - 1.2e-05 24.7 1.2 0.00095 18.6 0.0 3.9 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.10 ESS64750.1 - 0.006 16.3 1.4 3.3 7.6 0.0 3.1 3 0 0 3 3 3 2 Kelch motif Mpt_N PF09176.6 ESS64750.1 - 0.06 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal TPP_enzyme_N PF02776.13 ESS64751.1 - 4.3e-21 75.1 0.0 1.4e-20 73.4 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 ESS64751.1 - 6.8e-13 48.4 4.9 2e-11 43.6 1.6 3.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain UbiA PF01040.13 ESS64752.1 - 1.6e-25 89.8 19.4 2.3e-25 89.2 13.5 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4405 PF14358.1 ESS64752.1 - 0.35 11.0 4.8 1.4 9.0 3.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4405) NGP1NT PF08153.7 ESS64754.1 - 1.7e-42 144.4 0.2 1.7e-42 144.4 0.1 2.3 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 ESS64754.1 - 4.8e-20 71.6 1.2 2e-16 59.9 0.1 3.0 3 1 0 3 3 3 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESS64754.1 - 6.3e-06 26.1 4.9 0.3 10.8 0.0 4.2 3 2 1 4 4 4 2 Dynamin family FeoB_N PF02421.13 ESS64754.1 - 3.4e-05 23.1 0.2 9e-05 21.7 0.1 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 ESS64754.1 - 0.0026 16.9 0.0 0.0072 15.5 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESS64754.1 - 0.0036 16.7 0.0 1.9 7.8 0.0 3.4 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESS64754.1 - 0.0054 17.2 3.4 0.26 11.7 0.0 3.8 5 0 0 5 5 5 1 Miro-like protein MobB PF03205.9 ESS64754.1 - 0.014 15.1 0.5 0.44 10.2 0.1 3.0 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 ESS64754.1 - 0.098 12.6 0.0 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain ATP-synt_ab PF00006.20 ESS64755.1 - 2.1e-69 233.3 0.1 3.2e-69 232.7 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESS64755.1 - 0.0054 17.1 0.3 0.015 15.7 0.0 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain Pkinase PF00069.20 ESS64758.1 - 2.5e-73 246.4 0.0 2.9e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64758.1 - 1.7e-32 112.5 0.0 2.4e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS64758.1 - 0.0012 18.6 0.0 0.28 10.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS64758.1 - 0.033 13.2 0.0 0.079 12.0 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 ESS64758.1 - 0.035 12.9 0.0 0.057 12.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Motile_Sperm PF00635.21 ESS64759.1 - 0.00044 19.8 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DEAD PF00270.24 ESS64762.1 - 4.7e-35 120.5 0.1 3.2e-34 117.8 0.1 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS64762.1 - 3.6e-07 30.1 0.0 5.8e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C4H2 PF10146.4 ESS64762.1 - 0.057 13.4 0.4 0.092 12.7 0.3 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein NtA PF03146.10 ESS64762.1 - 0.072 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Agrin NtA domain AAA_22 PF13401.1 ESS64762.1 - 0.15 12.1 0.7 2.4 8.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain Helicase_C PF00271.26 ESS64763.1 - 1.1e-22 79.6 0.1 2.7e-22 78.4 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3357 PF11837.3 ESS64763.1 - 0.23 11.3 2.3 0.35 10.7 0.1 2.5 2 1 0 3 3 3 0 Domain of unknown function (DUF3357) COG4 PF08318.7 ESS64764.1 - 2.6e-60 203.9 1.9 2.9e-58 197.1 0.2 3.2 2 1 0 2 2 2 1 COG4 transport protein G-alpha PF00503.15 ESS64764.1 - 0.046 12.4 0.3 0.079 11.6 0.2 1.5 1 0 0 1 1 1 0 G-protein alpha subunit Surp PF01805.15 ESS64765.1 - 1e-13 50.7 0.1 1.8e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 Surp module ubiquitin PF00240.18 ESS64767.1 - 0.00025 20.3 0.0 0.00049 19.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family TPT PF03151.11 ESS64768.1 - 5.3e-12 45.6 5.8 5.3e-12 45.6 4.0 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 ESS64768.1 - 8.1e-07 28.2 21.6 1.4e-06 27.4 15.0 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESS64768.1 - 9e-05 22.5 3.6 9e-05 22.5 2.5 2.4 2 0 0 2 2 2 1 EamA-like transporter family Kinesin PF00225.18 ESS64769.1 - 3.1e-92 308.8 0.0 5.5e-92 308.0 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF4407 PF14362.1 ESS64769.1 - 0.013 14.4 1.9 0.029 13.3 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med3 PF11593.3 ESS64770.1 - 0.025 13.8 12.6 0.051 12.8 8.7 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SPX PF03105.14 ESS64770.1 - 0.076 12.7 5.5 0.24 11.1 4.3 1.4 1 1 0 1 1 1 0 SPX domain DUF3583 PF12126.3 ESS64770.1 - 0.54 9.2 8.7 0.054 12.5 2.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3583) NUC194 PF08163.7 ESS64770.1 - 1 8.1 5.3 1.4 7.7 3.7 1.1 1 0 0 1 1 1 0 NUC194 domain MDFI PF15316.1 ESS64770.1 - 1.4 8.8 3.4 2.7 7.9 2.4 1.4 1 0 0 1 1 1 0 MyoD family inhibitor Macoilin PF09726.4 ESS64770.1 - 2.5 6.2 9.9 0.62 8.2 4.3 1.7 1 1 0 1 1 1 0 Transmembrane protein Ank_2 PF12796.2 ESS64772.1 - 1.3e-51 172.8 2.6 6.6e-13 48.8 0.0 8.3 5 4 4 9 9 9 7 Ankyrin repeats (3 copies) Ank PF00023.25 ESS64772.1 - 3.4e-43 143.3 29.4 2.5e-06 27.0 0.0 14.9 15 0 0 15 15 15 10 Ankyrin repeat Ank_3 PF13606.1 ESS64772.1 - 1.6e-37 123.7 14.5 0.0025 17.8 0.0 15.2 15 0 0 15 15 15 8 Ankyrin repeat Ank_5 PF13857.1 ESS64772.1 - 5.2e-37 125.0 27.4 9.6e-06 25.6 0.1 13.0 7 4 7 14 14 14 10 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS64772.1 - 8e-34 115.4 14.1 7.2e-08 32.7 0.0 9.7 6 3 3 9 9 9 9 Ankyrin repeats (many copies) LRR_6 PF13516.1 ESS64773.1 - 1.6e-08 33.7 1.7 0.084 12.9 0.0 4.6 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 ESS64773.1 - 6.3e-08 32.0 2.1 0.0013 18.2 0.0 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESS64773.1 - 4.3e-05 23.0 5.0 7.7 7.1 0.7 4.6 4 0 0 4 4 4 2 Leucine rich repeat LRR_8 PF13855.1 ESS64773.1 - 0.00055 19.6 2.7 0.11 12.3 0.0 2.8 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESS64773.1 - 0.001 18.7 5.6 12 6.3 1.2 4.4 4 0 0 4 4 4 2 Leucine Rich Repeat Nitroreductase PF00881.19 ESS64774.1 - 3.3e-25 88.8 0.0 5.4e-25 88.1 0.0 1.4 1 1 0 1 1 1 1 Nitroreductase family DUF4139 PF13598.1 ESS64777.1 - 6.3e-71 239.2 2.4 7.9e-71 238.9 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) Viral_protease PF08715.5 ESS64778.1 - 0.71 8.8 3.4 1 8.3 2.3 1.1 1 0 0 1 1 1 0 Papain like viral protease SHIPPO-rpt PF07004.7 ESS64779.1 - 4.9e-28 96.5 19.8 0.0033 18.2 0.3 9.4 9 0 0 9 9 9 9 Sperm-tail PG-rich repeat SHIPPO-rpt PF07004.7 ESS64780.1 - 7.5e-37 124.3 141.7 0.00093 19.9 0.2 26.7 27 0 0 27 27 27 22 Sperm-tail PG-rich repeat DUF2076 PF09849.4 ESS64780.1 - 1.1 9.1 3.0 2.9 7.8 2.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PTS_EIIC_2 PF13303.1 ESS64781.1 - 0.067 12.0 0.3 0.1 11.4 0.2 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC Cyclin PF08613.6 ESS64782.1 - 4.5e-20 72.5 0.1 4.5e-20 72.5 0.0 2.7 3 1 0 3 3 3 1 Cyclin Cyclin_N PF00134.18 ESS64782.1 - 5.2e-06 26.0 0.5 1.1e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Zip PF02535.17 ESS64782.1 - 0.19 10.7 3.3 0.4 9.6 2.3 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4175 PF13779.1 ESS64782.1 - 6.9 4.2 11.8 9.9 3.7 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DSPc PF00782.15 ESS64783.1 - 3.8e-25 88.0 1.0 1.7e-09 37.3 0.2 3.8 3 0 0 3 3 3 3 Dual specificity phosphatase, catalytic domain HbrB PF08539.6 ESS64784.1 - 0.038 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 HbrB-like Helicase_IV_N PF12462.3 ESS64784.1 - 0.071 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Radical_SAM PF04055.16 ESS64785.1 - 8.6e-22 78.0 0.0 2.1e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 ESS64785.1 - 3.5e-21 75.0 0.1 6.7e-15 54.9 0.0 2.7 2 0 0 2 2 2 2 Wyosine base formation Flavodoxin_1 PF00258.20 ESS64785.1 - 3e-12 46.7 1.5 2.1e-11 43.9 0.0 2.7 3 0 0 3 3 3 1 Flavodoxin CDC45 PF02724.9 ESS64785.1 - 0.0023 16.0 3.3 0.0036 15.4 2.3 1.2 1 0 0 1 1 1 1 CDC45-like protein TPPK_C PF12555.3 ESS64785.1 - 0.096 12.4 0.7 0.21 11.3 0.5 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal TFIIA PF03153.8 ESS64785.1 - 1.9 8.2 13.2 0.53 10.1 7.0 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Kinesin PF00225.18 ESS64786.1 - 2.9e-86 289.2 0.0 6e-85 284.8 0.0 2.2 1 1 0 1 1 1 1 Kinesin motor domain MscS_porin PF12795.2 ESS64786.1 - 0.19 11.0 6.1 0.15 11.3 0.5 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Serinc PF03348.10 ESS64789.1 - 0.0004 19.2 7.5 0.0004 19.2 5.2 2.3 1 1 1 2 2 2 1 Serine incorporator (Serinc) DUF1510 PF07423.6 ESS64789.1 - 0.0033 16.8 5.1 0.0033 16.8 3.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) Suf PF05843.9 ESS64789.1 - 0.0058 16.4 7.6 0.0058 16.4 5.3 2.7 3 0 0 3 3 3 1 Suppressor of forked protein (Suf) Ycf1 PF05758.7 ESS64789.1 - 0.0058 14.4 1.1 0.0082 13.9 0.7 1.1 1 0 0 1 1 1 1 Ycf1 Pex14_N PF04695.8 ESS64789.1 - 0.0064 16.5 8.0 0.0064 16.5 5.5 3.9 3 1 0 4 4 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SID-1_RNA_chan PF13965.1 ESS64789.1 - 0.028 12.5 5.5 0.036 12.2 3.4 1.5 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 VirB3 PF05101.8 ESS64789.1 - 0.067 13.1 0.0 0.067 13.1 0.0 2.5 3 0 0 3 3 2 0 Type IV secretory pathway, VirB3-like protein Plasmodium_Vir PF05795.6 ESS64789.1 - 0.097 11.8 0.1 0.097 11.8 0.1 1.9 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Sec62 PF03839.11 ESS64789.1 - 0.16 11.3 2.6 0.37 10.1 1.8 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 Peptidase_S49_N PF08496.5 ESS64789.1 - 0.44 10.3 9.5 0.05 13.3 3.3 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal ETRAMP PF09716.5 ESS64789.1 - 0.68 9.9 1.4 1.8 8.5 0.1 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Spt20 PF12090.3 ESS64789.1 - 8.9 5.6 14.6 0.22 10.8 3.8 2.3 2 0 0 2 2 2 0 Spt20 family Zip PF02535.17 ESS64789.1 - 9.3 5.1 10.8 0.86 8.5 0.0 2.5 3 0 0 3 3 3 0 ZIP Zinc transporter Skp1 PF01466.14 ESS64790.1 - 0.093 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain ADH_zinc_N PF00107.21 ESS64791.1 - 3.1e-08 33.2 0.0 6e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESS64791.1 - 2.9e-06 27.0 0.4 1.3e-05 24.9 0.1 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain CDH PF02611.10 ESS64791.1 - 0.071 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase DGF-1_5 PF11038.3 ESS64792.1 - 2e-160 532.3 16.4 2e-160 532.3 11.3 2.4 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS64792.1 - 1.5e-45 152.9 0.9 4.5e-45 151.4 0.6 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS64792.1 - 1.2e-34 118.5 19.6 3.6e-34 116.9 13.6 1.9 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 PSP1 PF04468.7 ESS64796.1 - 8.8e-11 41.6 0.0 8.8e-11 41.6 0.0 2.5 3 0 0 3 3 3 1 PSP1 C-terminal conserved region TFIIA PF03153.8 ESS64796.1 - 0.54 10.1 14.9 0.7 9.7 10.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_M24 PF00557.19 ESS64797.1 - 1.7e-21 76.7 0.1 3.2e-21 75.8 0.2 1.5 2 0 0 2 2 2 1 Metallopeptidase family M24 PAT1 PF09770.4 ESS64798.1 - 0.00086 17.6 88.4 0.0011 17.3 61.3 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 GreA_GreB_N PF03449.10 ESS64798.1 - 8.7 6.4 12.0 2.4 8.2 1.5 2.6 1 1 0 2 2 2 0 Transcription elongation factor, N-terminal U-box PF04564.10 ESS64799.1 - 1.5e-06 28.0 0.0 3.8e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 ESS64799.1 - 0.013 14.9 0.0 0.034 13.6 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-DHHC PF01529.15 ESS64800.1 - 3.1e-28 98.3 4.1 3.1e-28 98.3 2.9 2.5 2 1 1 3 3 3 1 DHHC palmitoyltransferase MARVEL PF01284.18 ESS64800.1 - 0.003 17.3 2.4 0.047 13.5 0.0 2.4 2 0 0 2 2 2 1 Membrane-associating domain Phage_B PF02304.10 ESS64800.1 - 0.097 12.9 1.6 0.19 12.0 1.1 1.4 1 0 0 1 1 1 0 Scaffold protein B BUD22 PF09073.5 ESS64801.1 - 0.098 11.7 7.8 0.13 11.3 5.4 1.2 1 0 0 1 1 1 0 BUD22 BSP_II PF05432.6 ESS64801.1 - 0.11 11.7 9.1 0.16 11.2 6.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SDA1 PF05285.7 ESS64801.1 - 0.62 9.2 10.4 0.83 8.8 7.2 1.2 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.4 ESS64801.1 - 1 7.9 11.8 1.4 7.5 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) HEAT PF02985.17 ESS64802.1 - 0.0031 17.4 0.5 0.077 13.1 0.1 3.3 2 0 0 2 2 2 1 HEAT repeat HEAT_EZ PF13513.1 ESS64802.1 - 0.023 15.1 0.4 1 9.9 0.0 4.0 3 1 0 3 3 3 0 HEAT-like repeat Cse1 PF08506.5 ESS64802.1 - 0.047 12.2 0.0 0.31 9.5 0.0 2.3 3 0 0 3 3 3 0 Cse1 zf-C4pol PF14260.1 ESS64803.1 - 0.034 14.1 2.0 5.4 7.0 0.0 3.1 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta CorA PF01544.13 ESS64803.1 - 0.074 12.0 2.5 0.058 12.4 0.3 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF948 PF06103.6 ESS64803.1 - 0.13 12.1 1.2 9.8 6.1 0.1 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.1 ESS64803.1 - 0.94 7.8 6.7 0.14 10.5 0.3 2.1 2 0 0 2 2 2 0 AAA domain Amidinotransf PF02274.12 ESS64804.1 - 2.9e-05 23.3 0.0 0.0004 19.5 0.0 2.6 3 1 1 4 4 4 1 Amidinotransferase DUF4061 PF13270.1 ESS64805.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) DUF892 PF05974.7 ESS64805.1 - 0.13 12.0 0.4 11 5.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF892) Ax_dynein_light PF10211.4 ESS64806.1 - 0.082 12.7 0.7 0.12 12.1 0.5 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain F-actin_cap_A PF01267.12 ESS64807.1 - 3.1e-27 95.3 0.0 1.5e-25 89.7 0.0 2.9 1 1 0 1 1 1 1 F-actin capping protein alpha subunit DUF3077 PF11275.3 ESS64807.1 - 0.033 14.1 0.1 8.8 6.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3077) DUF179 PF02622.10 ESS64810.1 - 1.8e-29 102.4 0.0 2.7e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Rcd1 PF04078.8 ESS64810.1 - 0.21 10.4 0.0 0.3 9.8 0.0 1.1 1 0 0 1 1 1 0 Cell differentiation family, Rcd1-like DUF3612 PF12268.3 ESS64811.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3612) ASFV_J13L PF05568.6 ESS64812.1 - 0.1 12.1 0.7 0.5 9.8 0.5 2.1 1 1 0 1 1 1 0 African swine fever virus J13L protein DUF4515 PF14988.1 ESS64813.1 - 0.052 13.2 51.2 0.11 12.1 5.1 3.4 1 1 1 3 3 3 0 Domain of unknown function (DUF4515) DUF3508 PF12018.3 ESS64813.1 - 2.4 7.0 18.3 0.58 9.1 7.3 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3508) DUF1014 PF06244.7 ESS64814.1 - 1.6e-16 60.5 14.7 5.4e-15 55.6 10.2 2.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) Ycf1 PF05758.7 ESS64814.1 - 0.057 11.1 7.9 0.083 10.5 5.5 1.2 1 0 0 1 1 1 0 Ycf1 Sec63 PF02889.11 ESS64816.1 - 1.1e-155 517.5 0.4 2.3e-89 299.7 0.2 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 ESS64816.1 - 4.3e-53 179.2 0.8 1.4e-28 99.5 0.3 3.2 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.10 ESS64816.1 - 4e-22 78.9 0.0 2e-14 53.8 0.1 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESS64816.1 - 1.3e-17 63.4 0.0 1.9e-07 30.8 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESS64816.1 - 8.1e-09 34.6 0.1 2.9e-05 23.0 0.2 2.5 2 0 0 2 2 2 2 SNF2 family N-terminal domain AAA_22 PF13401.1 ESS64816.1 - 1.6e-07 31.5 0.0 0.0038 17.3 0.0 3.5 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESS64816.1 - 1.1e-06 28.3 0.0 0.015 15.0 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_10 PF12846.2 ESS64816.1 - 2.3e-05 24.0 2.7 1.1 8.6 0.0 4.6 4 1 0 5 5 5 2 AAA-like domain T2SE PF00437.15 ESS64816.1 - 3.6e-05 22.8 0.0 0.026 13.4 0.0 3.2 3 0 0 3 3 3 2 Type II/IV secretion system protein PhoH PF02562.11 ESS64816.1 - 0.00074 18.8 0.1 0.68 9.1 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.4 ESS64816.1 - 0.0015 17.5 0.0 0.0038 16.2 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.16 ESS64816.1 - 0.091 12.0 0.1 2.9 7.1 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.24 ESS64816.1 - 0.12 12.5 2.8 2.5 8.2 0.1 3.9 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESS64816.1 - 0.2 11.9 0.0 1.9 8.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain His_Phos_1 PF00300.17 ESS64817.1 - 4.1e-10 39.9 0.0 1.3e-09 38.3 0.0 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) BBP1_C PF15272.1 ESS64818.1 - 0.0016 18.0 13.4 0.0016 18.0 9.3 4.2 1 1 3 4 4 4 1 Spindle pole body component BBP1, C-terminal TMF_TATA_bd PF12325.3 ESS64818.1 - 0.0032 17.1 4.8 0.0032 17.1 3.3 6.1 4 2 1 6 6 6 1 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.7 ESS64818.1 - 0.0041 16.9 25.6 0.0064 16.2 2.2 4.6 3 2 1 5 5 5 2 Protein of unknown function (DUF1664) Spc7 PF08317.6 ESS64818.1 - 0.0044 15.7 6.7 0.0044 15.7 4.7 3.8 2 1 1 4 4 4 1 Spc7 kinetochore protein DUF3598 PF12204.3 ESS64818.1 - 0.017 14.4 0.5 0.017 14.4 0.3 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF3598) Acetyltransf_11 PF13720.1 ESS64818.1 - 0.06 13.5 2.5 0.18 12.0 0.2 3.0 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Reo_sigmaC PF04582.7 ESS64818.1 - 5.3 6.1 10.1 5 6.2 1.0 2.6 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF4062 PF13271.1 ESS64819.1 - 0.066 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) C2 PF00168.25 ESS64820.1 - 0.068 13.0 0.1 0.36 10.6 0.0 2.1 2 0 0 2 2 2 0 C2 domain FAD_binding_8 PF08022.7 ESS64822.1 - 1.8e-12 47.0 0.0 2.7e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 ESS64822.1 - 7.9e-09 35.5 0.0 1.1e-07 31.8 0.0 2.1 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 ESS64822.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESS64822.1 - 0.0019 18.7 0.0 2 9.0 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain Ferric_reduct PF01794.14 ESS64822.1 - 0.019 15.0 3.0 0.021 14.8 1.0 1.8 1 1 1 2 2 2 0 Ferric reductase like transmembrane component JTB PF05439.7 ESS64822.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) Wzy_C PF04932.10 ESS64823.1 - 0.67 9.7 5.2 0.88 9.3 3.6 1.2 1 1 0 1 1 1 0 O-Antigen ligase IQ PF00612.22 ESS64825.1 - 2e-17 61.1 38.6 0.0011 18.4 0.2 7.4 6 0 0 6 6 6 6 IQ calmodulin-binding motif Pkinase PF00069.20 ESS64826.1 - 5.4e-12 45.4 0.3 8.1e-12 44.8 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESS64826.1 - 0.063 12.6 0.2 0.12 11.7 0.1 1.4 1 1 0 1 1 1 0 RIO1 family Hid1 PF12722.2 ESS64827.1 - 3.1e-40 137.7 1.5 5.1e-39 133.6 0.8 2.8 2 1 0 2 2 2 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 ESS64827.1 - 2.5e-28 98.6 0.2 1.8e-27 95.8 0.2 2.1 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein EF-hand_1 PF00036.27 ESS64828.1 - 1.8e-23 80.0 0.8 5.6e-07 28.4 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 ESS64828.1 - 3e-22 78.5 6.3 1e-12 47.9 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS64828.1 - 3.4e-19 66.9 3.1 0.00037 20.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 ESS64828.1 - 6.8e-17 60.8 6.2 1.2e-05 24.8 0.1 4.4 5 0 0 5 5 4 3 EF-hand domain pair EF-hand_5 PF13202.1 ESS64828.1 - 1.9e-16 58.5 5.1 0.0013 18.0 0.0 4.7 5 0 0 5 5 5 4 EF hand zf-C3HC4_3 PF13920.1 ESS64828.1 - 1.6e-08 34.0 6.7 1.6e-08 34.0 4.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS64828.1 - 2.3e-07 30.3 3.9 2.3e-07 30.3 2.7 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS64828.1 - 3.4e-07 30.1 7.1 3.4e-07 30.1 5.0 2.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS64828.1 - 1e-05 25.1 8.8 1e-05 25.1 6.1 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.1 ESS64828.1 - 5e-05 22.9 6.1 0.00011 21.8 4.3 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.1 ESS64828.1 - 0.00013 21.6 12.8 0.00036 20.2 8.4 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.1 ESS64828.1 - 0.00022 21.0 3.4 0.00022 21.0 2.4 2.9 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING SPARC_Ca_bdg PF10591.4 ESS64828.1 - 0.00061 19.8 0.0 0.029 14.3 0.0 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region zf-RING_UBOX PF13445.1 ESS64828.1 - 0.013 15.1 9.7 0.019 14.7 1.4 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.1 ESS64828.1 - 0.15 11.6 6.9 0.3 10.6 4.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.3 ESS64828.1 - 0.24 10.9 3.3 0.75 9.3 2.3 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.15 ESS64828.1 - 1.7 8.2 9.4 7 6.2 4.9 2.9 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger DNA_mis_repair PF01119.14 ESS64829.1 - 1.2e-24 86.0 0.0 2.3e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 ESS64829.1 - 6e-09 35.6 0.0 1.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESS64829.1 - 9e-08 31.8 0.0 2.1e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2040 PF09745.4 ESS64829.1 - 6.7 6.5 11.5 0.72 9.6 4.9 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) Kinesin PF00225.18 ESS64830.1 - 2.3e-60 204.0 0.1 1e-42 146.0 0.0 2.7 2 1 0 2 2 2 2 Kinesin motor domain T2SE PF00437.15 ESS64830.1 - 0.0086 15.0 1.0 0.011 14.6 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.1 ESS64830.1 - 0.31 11.3 1.7 32 4.7 2.0 2.5 2 0 0 2 2 2 0 AAA domain HpcH_HpaI PF03328.9 ESS64831.1 - 6.6e-05 21.8 0.0 0.0012 17.7 0.0 2.6 2 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 ESS64831.1 - 0.0014 17.5 0.0 0.0037 16.1 0.0 1.6 2 0 0 2 2 2 1 C-C_Bond_Lyase of the TIM-Barrel fold Pkinase PF00069.20 ESS64832.1 - 1.5e-64 217.6 0.0 1.9e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64832.1 - 2e-39 135.2 0.0 2.7e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase zinc_ribbon_2 PF13240.1 ESS64832.1 - 4.7e-06 25.8 2.4 1.1e-05 24.7 1.6 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESS64832.1 - 0.00011 21.2 5.9 0.0003 19.8 4.1 1.7 1 1 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 ESS64832.1 - 0.00019 21.1 1.0 0.00037 20.2 0.7 1.4 1 0 0 1 1 1 1 Double zinc ribbon Kdo PF06293.9 ESS64832.1 - 0.0031 16.6 0.0 0.0067 15.5 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS64832.1 - 0.0089 15.7 0.0 0.071 12.8 0.0 2.2 1 1 2 3 3 3 1 Phosphotransferase enzyme family zf-NADH-PPase PF09297.6 ESS64832.1 - 0.014 14.9 6.2 0.16 11.4 0.6 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Kinase-like PF14531.1 ESS64832.1 - 0.044 12.7 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like NOB1_Zn_bind PF08772.6 ESS64832.1 - 0.59 9.9 4.1 1.3 8.9 2.8 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Zn_ribbon_recom PF13408.1 ESS64832.1 - 2.7 8.3 6.3 15 5.8 4.4 2.2 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Nudix_N_2 PF14803.1 ESS64832.1 - 3.1 7.5 4.7 5.7 6.7 0.4 2.4 2 0 0 2 2 2 0 Nudix N-terminal UPF0547 PF10571.4 ESS64832.1 - 5 6.8 6.6 2.6 7.8 0.2 2.3 1 1 1 2 2 2 0 Uncharacterised protein family UPF0547 cIII PF08134.6 ESS64833.1 - 0.37 10.4 2.0 0.51 9.9 0.0 2.2 3 0 0 3 3 3 0 cIII protein family Rab5ip PF07019.7 ESS64834.1 - 0.02 14.9 0.0 0.024 14.7 0.0 1.1 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) WD40 PF00400.27 ESS64835.1 - 0.047 13.5 0.1 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat WD40 PF00400.27 ESS64836.1 - 0.00012 21.8 3.9 4.7 7.2 0.0 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESS64836.1 - 0.055 12.2 0.0 0.32 9.7 0.0 1.9 1 1 0 2 2 2 0 Nup133 N terminal like WD40 PF00400.27 ESS64837.1 - 2.9e-19 68.1 3.0 4.6e-07 29.4 0.1 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat SH2 PF00017.19 ESS64837.1 - 0.11 12.3 0.0 2.4 8.0 0.0 2.7 3 0 0 3 3 3 0 SH2 domain ERCC4 PF02732.10 ESS64838.1 - 1.1e-20 73.8 0.0 2.2e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain SAP PF02037.22 ESS64838.1 - 1.9e-08 33.5 1.6 4.8e-08 32.3 1.1 1.7 1 0 0 1 1 1 1 SAP domain Tweety PF04906.8 ESS64839.1 - 0.0044 15.4 2.2 0.0068 14.8 1.5 1.2 1 0 0 1 1 1 1 Tweety Prominin PF05478.6 ESS64839.1 - 0.014 12.9 0.2 0.018 12.6 0.2 1.1 1 0 0 1 1 1 0 Prominin DUF588 PF04535.7 ESS64839.1 - 0.057 12.9 2.6 0.11 12.0 1.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF588) Helicase_C PF00271.26 ESS64840.1 - 2.7e-15 55.9 0.0 3.6e-14 52.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS64840.1 - 9.5e-14 51.2 0.0 2.8e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HRDC PF00570.18 ESS64840.1 - 2.7e-10 39.8 0.0 5.1e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 HRDC domain Clat_adaptor_s PF01217.15 ESS64841.1 - 1.3e-41 141.6 0.6 1.4e-41 141.4 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CRISPR_Cse2 PF09485.5 ESS64843.1 - 0.0044 17.0 0.9 1.6 8.7 0.0 2.9 2 1 0 2 2 2 2 CRISPR-associated protein Cse2 (CRISPR_cse2) EF-hand_1 PF00036.27 ESS64843.1 - 0.086 12.1 0.0 2.9 7.4 0.0 2.6 2 0 0 2 2 2 0 EF hand RRM_1 PF00076.17 ESS64844.1 - 6.5e-34 115.3 0.7 1.9e-19 69.0 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS64844.1 - 2.1e-25 88.4 0.5 3.3e-14 52.5 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS64844.1 - 1.3e-14 53.7 0.2 1e-08 34.8 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESS64844.1 - 1.7e-07 30.9 0.1 0.023 14.4 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 ESS64844.1 - 0.003 17.2 0.1 0.62 9.8 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 ESS64844.1 - 0.17 11.6 1.7 0.56 10.0 0.1 2.4 2 1 0 2 2 2 0 Limkain b1 UBA PF00627.26 ESS64845.1 - 2.1e-05 24.1 0.2 3.5e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Rhomboid PF01694.17 ESS64845.1 - 0.0035 17.3 0.6 0.0053 16.7 0.4 1.3 1 0 0 1 1 1 1 Rhomboid family Tom37 PF10568.4 ESS64846.1 - 7.6e-06 26.1 0.0 1.6e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_3 PF14497.1 ESS64846.1 - 0.0013 19.1 0.0 0.0036 17.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESS64846.1 - 0.0042 16.9 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DEC-1_N PF04625.8 ESS64846.1 - 3.7 6.1 17.0 3 6.4 10.7 1.6 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region Med3 PF11593.3 ESS64846.1 - 8.6 5.4 11.3 13 4.8 7.9 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FAD_binding_2 PF00890.19 ESS64847.1 - 6.9e-115 384.2 1.0 6.9e-115 384.2 0.7 1.5 2 0 0 2 2 2 1 FAD binding domain Succ_DH_flav_C PF02910.15 ESS64847.1 - 8.3e-43 145.3 0.5 1.2e-42 144.8 0.3 1.2 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term DAO PF01266.19 ESS64847.1 - 1.8e-05 23.8 0.3 0.021 13.7 0.1 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.12 ESS64847.1 - 5.8e-05 22.2 0.1 0.037 13.1 0.1 3.1 3 0 0 3 3 3 1 Thi4 family Pyr_redox_2 PF07992.9 ESS64847.1 - 0.00013 21.9 0.0 0.01 15.7 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS64847.1 - 0.0022 16.9 2.7 0.1 11.4 1.7 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.9 ESS64847.1 - 0.016 13.6 0.2 0.032 12.6 0.1 1.5 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.7 ESS64847.1 - 0.022 13.6 2.1 1 8.2 0.3 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Amastin PF07344.6 ESS64848.1 - 5e-07 29.4 5.2 7.7e-07 28.8 3.6 1.3 1 1 0 1 1 1 1 Amastin surface glycoprotein DUF2909 PF11137.3 ESS64848.1 - 0.5 10.1 0.1 0.5 10.1 0.0 3.3 4 1 0 4 4 4 0 Protein of unknown function (DUF2909) DUF2207 PF09972.4 ESS64848.1 - 0.86 8.1 6.9 0.062 11.8 1.1 1.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) COX8 PF02285.10 ESS64848.1 - 1.9 8.1 3.7 1.3 8.5 0.1 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII Neurensin PF14927.1 ESS64848.1 - 4.8 6.5 9.2 0.18 11.2 1.9 1.8 2 1 0 2 2 2 0 Neurensin NAD_binding_4 PF07993.7 ESS64850.1 - 2.9e-62 209.8 0.0 4.1e-62 209.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.14 ESS64850.1 - 2.6e-08 33.9 0.2 5e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 ESS64850.1 - 5.6e-08 32.5 0.0 4.5e-07 29.5 0.0 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESS64850.1 - 2.6e-05 23.2 0.3 0.066 12.1 0.1 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain 3Beta_HSD PF01073.14 ESS64850.1 - 0.0058 15.3 0.4 3.5 6.2 0.0 3.0 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 ESS64850.1 - 0.013 14.3 0.1 0.094 11.5 0.1 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF533 PF04391.7 ESS64850.1 - 0.036 13.4 1.9 0.071 12.4 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Peptidase_M8 PF01457.11 ESS64851.1 - 3.7e-06 25.5 0.1 4.9e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Leishmanolysin Mucin PF01456.12 ESS64851.1 - 0.0041 16.8 0.0 0.0041 16.8 0.0 2.9 3 0 0 3 3 3 1 Mucin-like glycoprotein SpoU_methylase PF00588.14 ESS64852.1 - 2.8e-16 59.6 0.0 4.6e-14 52.4 0.0 3.3 3 1 0 3 3 3 1 SpoU rRNA Methylase family DUF4594 PF15266.1 ESS64853.1 - 0.33 11.0 9.8 1 9.5 2.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4594) Ssl1 PF04056.9 ESS64854.1 - 2.1e-26 92.7 0.0 3e-13 49.7 0.0 2.1 2 0 0 2 2 2 2 Ssl1-like C1_4 PF07975.7 ESS64854.1 - 0.0036 17.2 8.6 0.0036 17.2 6.0 2.7 2 1 0 2 2 2 1 TFIIH C1-like domain zf-C3HC4_3 PF13920.1 ESS64854.1 - 9.4 5.9 29.4 0.97 9.1 8.5 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) SET PF00856.23 ESS64855.1 - 1e-07 32.4 0.3 1.3e-06 28.8 0.2 2.3 1 1 0 1 1 1 1 SET domain WD40 PF00400.27 ESS64857.1 - 5.6e-30 102.1 17.3 2.9e-07 30.0 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ESS64857.1 - 1.8e-05 24.5 0.0 0.007 16.0 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 ESS64857.1 - 0.023 14.1 0.1 0.46 10.0 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1391 PF07151.7 ESS64857.1 - 0.071 12.6 0.1 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1391) GST_C_3 PF14497.1 ESS64858.1 - 4.6e-08 33.4 0.0 1.1e-07 32.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESS64858.1 - 6.1e-06 26.0 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.4 ESS64858.1 - 4.8e-05 23.5 0.0 8.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_2 PF13409.1 ESS64858.1 - 0.00021 21.1 0.0 0.00042 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 ESS64858.1 - 0.00041 20.5 0.0 0.0011 19.0 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESS64858.1 - 0.039 13.9 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Med14 PF08638.6 ESS64858.1 - 0.05 12.8 0.2 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 Mediator complex subunit MED14 TRAPP PF04051.11 ESS64859.1 - 3.9e-23 81.6 0.0 5e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PH PF00169.24 ESS64860.1 - 2.2e-12 47.0 0.0 3.4e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESS64860.1 - 0.004 17.3 0.1 0.0096 16.1 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.1 ESS64860.1 - 0.049 13.5 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 PH domain TCTP PF00838.12 ESS64861.1 - 6.9e-39 133.4 2.2 7.8e-39 133.3 1.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Ribosomal_S20p PF01649.13 ESS64861.1 - 0.076 13.4 0.4 0.11 12.8 0.3 1.3 1 0 0 1 1 1 0 Ribosomal protein S20 DUF3384 PF11864.3 ESS64861.1 - 0.14 10.5 0.0 0.17 10.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) DUF1292 PF06949.6 ESS64861.1 - 1.1 9.7 6.0 4 7.8 0.0 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1292) GTP_EFTU PF00009.22 ESS64862.1 - 7.6e-25 87.4 1.2 3e-24 85.5 0.9 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESS64862.1 - 4e-07 30.5 0.7 2.1e-06 28.2 0.2 2.4 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 ESS64862.1 - 6.2e-07 29.3 0.1 1.5e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ESS64862.1 - 0.00011 21.7 0.3 0.002 17.6 0.1 3.0 3 1 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.17 ESS64862.1 - 0.00011 21.6 0.1 0.00036 19.9 0.0 1.9 2 0 0 2 2 2 1 Ras family FeoB_N PF02421.13 ESS64862.1 - 0.0013 18.0 0.1 0.0026 17.0 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.5 ESS64862.1 - 0.0013 17.9 0.8 0.0051 16.0 0.1 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ESS64862.1 - 0.022 14.7 0.2 0.51 10.3 0.1 2.6 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 ESS64862.1 - 0.033 13.3 0.0 0.068 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 IF-2 PF11987.3 ESS64862.1 - 0.048 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Translation-initiation factor 2 Dynamin_N PF00350.18 ESS64862.1 - 1.2 8.9 6.5 5.6 6.7 0.0 3.3 3 1 1 4 4 4 0 Dynamin family START PF01852.14 ESS64863.1 - 3.8e-09 36.1 0.0 8.6e-09 35.0 0.0 1.5 1 1 0 1 1 1 1 START domain DUF987 PF06174.6 ESS64863.1 - 0.072 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF987) ubiquitin PF00240.18 ESS64865.1 - 1.5e-06 27.5 0.0 4.5e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 ESS64865.1 - 4e-05 23.7 0.3 0.00017 21.6 0.2 2.1 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain FimP PF09766.4 ESS64865.1 - 0.0004 19.5 1.9 0.00066 18.8 1.3 1.3 1 0 0 1 1 1 1 Fms-interacting protein DUF4175 PF13779.1 ESS64865.1 - 0.0047 14.7 18.9 0.0089 13.7 13.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Tim54 PF11711.3 ESS64865.1 - 0.018 13.6 0.7 0.034 12.7 0.5 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Glt_symporter PF03616.9 ESS64865.1 - 0.096 11.1 0.5 0.15 10.5 0.4 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF4557 PF15101.1 ESS64865.1 - 0.1 12.3 8.8 0.2 11.4 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Serinc PF03348.10 ESS64865.1 - 1.5 7.4 3.3 2.3 6.8 2.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) PAT1 PF09770.4 ESS64865.1 - 2.3 6.3 24.4 3.6 5.6 16.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0560 PF10577.4 ESS64865.1 - 3.3 5.8 11.1 5.9 5.0 7.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4131 PF13567.1 ESS64866.1 - 5.9 6.2 7.6 10 5.5 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) C2 PF00168.25 ESS64868.1 - 2.6e-14 52.8 0.0 6.2e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.12 ESS64868.1 - 0.0043 17.4 3.3 1.1 9.6 0.0 3.5 4 0 0 4 4 4 2 Putative heavy-metal-binding DSPc PF00782.15 ESS64869.1 - 5.1e-09 35.7 0.2 8.2e-08 31.9 0.0 2.8 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS64869.1 - 0.0096 15.2 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pkinase PF00069.20 ESS64870.1 - 8.7e-41 139.7 0.1 8.2e-35 120.1 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64870.1 - 2.3e-16 59.6 0.0 5.2e-16 58.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase DUF4599 PF15371.1 ESS64870.1 - 0.00025 21.0 1.5 0.00068 19.6 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4599) Kinase-like PF14531.1 ESS64870.1 - 0.079 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like CheB_methylest PF01339.12 ESS64870.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 CheB methylesterase DUF2392 PF10288.4 ESS64871.1 - 5.6e-08 33.0 0.0 9.8e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) ATP_bind_3 PF01171.15 ESS64871.1 - 0.027 13.9 0.0 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 PP-loop family PDZ_2 PF13180.1 ESS64876.1 - 0.00019 21.2 0.0 0.00052 19.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 ESS64876.1 - 0.016 15.3 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Peptidase_M16 PF00675.15 ESS64879.1 - 4.4e-07 29.7 0.1 4.1e-06 26.6 0.1 2.3 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESS64879.1 - 5.5e-07 29.4 0.0 1.3e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Kelch_6 PF13964.1 ESS64881.1 - 0.0014 18.6 0.3 0.14 12.3 0.0 3.2 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.1 ESS64881.1 - 0.025 14.5 2.1 0.04 13.8 0.0 2.3 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.1 ESS64881.1 - 0.039 13.7 1.1 0.89 9.3 0.0 3.0 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS64881.1 - 0.92 9.7 3.3 9.1 6.5 0.1 3.3 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_4 PF13418.1 ESS64882.1 - 8.1e-18 63.9 3.3 7.2e-07 28.8 0.1 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain BTB_2 PF02214.17 ESS64882.1 - 2.2e-12 46.9 1.1 2e-10 40.7 0.1 2.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.20 ESS64882.1 - 4.5e-12 45.3 0.2 0.0022 17.4 0.0 3.6 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 ESS64882.1 - 9.1e-11 41.4 0.4 0.024 14.6 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 ESS64882.1 - 3.6e-10 39.7 6.8 1.9e-06 27.8 0.1 4.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESS64882.1 - 9.1e-09 35.1 1.2 0.0016 18.5 0.1 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 ESS64882.1 - 0.0003 20.4 2.1 0.43 10.4 0.1 3.5 3 0 0 3 3 3 1 Kelch motif GDE_C PF06202.9 ESS64882.1 - 0.0049 15.6 0.0 0.0088 14.8 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase LRR_6 PF13516.1 ESS64886.1 - 1.2e-10 40.3 0.2 0.00043 20.0 0.0 2.8 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.2 ESS64886.1 - 2e-05 24.0 0.0 6.6e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS64886.1 - 0.00015 21.3 0.4 0.13 12.3 0.0 3.2 2 0 0 2 2 2 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS64886.1 - 0.00018 21.1 0.0 0.46 10.8 0.0 3.4 2 0 0 2 2 2 2 Leucine rich repeat LRR_8 PF13855.1 ESS64886.1 - 0.079 12.7 0.1 0.42 10.3 0.1 2.1 1 1 0 1 1 1 0 Leucine rich repeat Ax_dynein_light PF10211.4 ESS64887.1 - 0.00071 19.4 4.7 0.00071 19.4 3.2 3.2 3 0 0 3 3 3 1 Axonemal dynein light chain Seadorna_VP6 PF07407.6 ESS64887.1 - 0.3 9.7 1.7 0.55 8.9 1.2 1.3 1 0 0 1 1 1 0 Seadornavirus VP6 protein Glyco_transf_25 PF01755.12 ESS64888.1 - 5.6e-17 62.0 0.0 5.4e-15 55.5 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) TRM PF02005.11 ESS64889.1 - 2e-101 339.6 1.6 1.4e-72 244.6 0.9 3.0 2 1 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Actin PF00022.14 ESS64890.1 - 8.1e-96 320.8 0.0 9.2e-96 320.6 0.0 1.0 1 0 0 1 1 1 1 Actin AAA PF00004.24 ESS64891.1 - 3.9e-36 124.1 0.0 6.3e-36 123.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESS64891.1 - 7.5e-06 25.7 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.7 ESS64891.1 - 8.7e-06 24.9 0.0 1.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESS64891.1 - 1.1e-05 25.5 0.1 0.00024 21.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESS64891.1 - 0.00074 18.3 0.0 0.0014 17.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_18 PF13238.1 ESS64891.1 - 0.00082 19.6 1.0 0.011 16.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESS64891.1 - 0.0014 18.0 0.1 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 ESS64891.1 - 0.0018 18.0 0.1 0.0065 16.1 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 ESS64891.1 - 0.0018 19.1 0.1 0.0073 17.1 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESS64891.1 - 0.0056 16.6 0.0 0.015 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 ESS64891.1 - 0.008 15.5 0.3 0.18 11.1 0.2 2.3 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESS64891.1 - 0.008 15.9 0.1 0.019 14.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS64891.1 - 0.012 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 ESS64891.1 - 0.017 14.7 0.1 0.042 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESS64891.1 - 0.02 14.7 0.0 0.02 14.7 0.0 2.4 3 0 0 3 3 1 0 AAA domain RNA_helicase PF00910.17 ESS64891.1 - 0.023 14.8 0.0 0.055 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase KaiC PF06745.8 ESS64891.1 - 0.032 13.3 0.1 0.72 8.9 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_2 PF07724.9 ESS64891.1 - 0.037 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 ESS64891.1 - 0.045 13.6 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ESS64891.1 - 0.052 12.7 0.0 0.097 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein LisH PF08513.6 ESS64891.1 - 0.054 13.2 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 LisH AAA_28 PF13521.1 ESS64891.1 - 0.056 13.4 0.1 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESS64891.1 - 0.059 12.8 0.0 1.8 8.0 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain A_deaminase PF00962.17 ESS64893.1 - 3.4e-74 249.7 0.0 9e-74 248.3 0.0 1.7 2 0 0 2 2 2 1 Adenosine/AMP deaminase MRJP PF03022.11 ESS64893.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Major royal jelly protein DUF615 PF04751.9 ESS64894.1 - 0.12 12.0 0.1 0.34 10.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Cas_Cas6 PF01881.11 ESS64895.1 - 0.0044 17.2 0.4 0.0044 17.2 0.3 2.0 2 0 0 2 2 2 1 CRISPR associated protein Cas6 Coa1 PF08695.5 ESS64898.1 - 0.17 11.3 0.8 12 5.4 0.4 2.3 1 1 1 2 2 2 0 Cytochrome oxidase complex assembly protein 1 DUF4131 PF13567.1 ESS64898.1 - 6.2 6.2 11.8 2.2 7.6 6.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) Peptidase_S8 PF00082.17 ESS64899.1 - 4.4e-24 85.1 0.0 7e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Subtilase family Dpy-30 PF05186.8 ESS64901.1 - 2.1e-07 30.2 0.1 3.6e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Dpy-30 motif cNMP_binding PF00027.24 ESS64904.1 - 4.3e-09 36.0 1.0 1.6e-05 24.6 0.1 3.6 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain DUF3835 PF12927.2 ESS64904.1 - 1.4 9.9 7.4 0.59 11.1 3.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3835) DNA_primase_S PF01896.14 ESS64905.1 - 5.7e-39 133.2 0.0 9e-39 132.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit SIS_2 PF13580.1 ESS64906.1 - 0.038 13.7 0.0 0.5 10.0 0.0 2.5 2 0 0 2 2 2 0 SIS domain THF_DHG_CYH_C PF02882.14 ESS64908.1 - 1.1e-41 141.6 0.7 3e-41 140.1 0.5 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 ESS64908.1 - 1.2e-29 102.6 0.0 1.9e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Bclx_interact PF08945.5 ESS64908.1 - 0.039 13.4 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain SEP PF08059.8 ESS64910.1 - 1.5e-09 37.9 0.0 3e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 SEP domain Carn_acyltransf PF00755.15 ESS64911.1 - 1.3e-135 452.7 0.0 1.6e-135 452.5 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase API5 PF05918.6 ESS64912.1 - 0.00025 19.6 0.1 0.00025 19.6 0.0 2.8 3 0 0 3 3 3 1 Apoptosis inhibitory protein 5 (API5) DUF2702 PF10863.3 ESS64912.1 - 0.11 12.1 0.2 5.8 6.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2702) Mito_carr PF00153.22 ESS64913.1 - 8.9e-12 44.5 0.8 1.9e-08 33.8 0.1 3.4 3 0 0 3 3 3 2 Mitochondrial carrier protein Trypan_glycop_C PF10659.4 ESS64913.1 - 0.019 15.2 0.2 0.032 14.4 0.1 1.3 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain DUF3317 PF11779.3 ESS64914.1 - 0.11 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) TRAP_alpha PF03896.11 ESS64915.1 - 1.1e-17 63.9 0.0 1.4e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Wzt_C PF14524.1 ESS64915.1 - 0.059 13.0 0.1 0.09 12.4 0.1 1.2 1 0 0 1 1 1 0 Wzt C-terminal domain DUF883 PF05957.8 ESS64919.1 - 1.3e-06 28.7 15.1 0.52 10.7 0.1 4.3 2 2 2 4 4 4 3 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.13 ESS64919.1 - 2.1e-06 27.4 4.8 0.0056 16.2 0.2 2.7 2 1 0 2 2 2 2 Apolipoprotein A1/A4/E domain DUF4456 PF14644.1 ESS64919.1 - 0.0016 17.6 1.5 0.22 10.7 0.2 2.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4456) OSCP PF00213.13 ESS64919.1 - 0.0054 16.6 2.2 0.0054 16.6 1.5 2.0 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit Serine_rich PF08824.5 ESS64919.1 - 0.027 14.2 1.5 0.38 10.4 0.0 2.6 2 1 0 2 2 2 0 Serine rich protein interaction domain Peptidase_S64 PF08192.6 ESS64919.1 - 0.028 12.7 2.1 0.033 12.5 1.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 zf-ZPR1 PF03367.8 ESS64919.1 - 0.14 11.3 1.7 7 5.7 0.1 2.4 2 0 0 2 2 2 0 ZPR1 zinc-finger domain AIP3 PF03915.8 ESS64919.1 - 0.18 10.6 6.2 0.32 9.8 4.3 1.4 1 1 0 1 1 1 0 Actin interacting protein 3 MT0933_antitox PF14013.1 ESS64919.1 - 0.19 11.8 4.0 0.55 10.3 0.2 3.4 3 1 0 3 3 3 0 MT0933-like antitoxin protein DUF842 PF05811.8 ESS64919.1 - 0.22 11.0 3.4 0.23 10.8 0.2 2.4 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) LMP PF04778.7 ESS64919.1 - 0.27 10.9 4.6 0.73 9.5 0.2 2.5 2 1 0 2 2 2 0 LMP repeated region YtxH PF12732.2 ESS64919.1 - 1.1 9.6 15.8 0.22 11.9 1.0 3.8 2 2 0 2 2 2 0 YtxH-like protein DUF3359 PF11839.3 ESS64919.1 - 1.1 9.5 8.0 0.2 12.0 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3359) Phasin PF05597.6 ESS64919.1 - 4.1 7.1 13.7 5 6.8 0.5 3.7 2 2 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3552 PF12072.3 ESS64919.1 - 6.7 5.8 13.3 0.17 11.1 1.9 2.9 2 2 0 2 2 2 0 Domain of unknown function (DUF3552) ApoLp-III PF07464.6 ESS64919.1 - 6.7 6.7 11.0 9.5 6.2 2.0 2.7 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) ATP-synt_B PF00430.13 ESS64919.1 - 7.3 6.4 12.9 4.8 6.9 0.9 3.2 2 2 1 3 3 3 0 ATP synthase B/B' CF(0) zf-CCCH PF00642.19 ESS64921.1 - 0.0047 16.5 3.2 0.0047 16.5 2.3 3.6 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS64921.1 - 0.56 10.2 8.6 4 7.5 0.1 3.2 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type LRV_FeS PF05484.6 ESS64921.1 - 2.6 7.6 9.3 0.17 11.4 0.6 2.5 2 0 0 2 2 2 0 LRV protein FeS4 cluster DUF2036 PF09724.4 ESS64922.1 - 6.5e-92 308.1 0.0 7.4e-92 307.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) YukD PF08817.5 ESS64923.1 - 0.027 15.0 0.0 6.3 7.4 0.0 2.7 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD zf-CCCH PF00642.19 ESS64924.1 - 0.013 15.2 3.7 0.013 15.2 2.6 2.6 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DinB_2 PF12867.2 ESS64925.1 - 0.068 13.5 5.2 7.5 6.9 3.6 2.6 1 1 0 1 1 1 0 DinB superfamily DUF4446 PF14584.1 ESS64925.1 - 0.098 12.4 0.0 0.098 12.4 0.0 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF4446) YPEB PF14620.1 ESS64925.1 - 0.16 10.9 9.6 0.059 12.3 0.7 2.3 1 1 0 2 2 2 0 YpeB sporulation IncA PF04156.9 ESS64925.1 - 0.46 10.0 28.7 2.5 7.6 6.4 2.7 1 1 2 3 3 3 0 IncA protein ERM PF00769.14 ESS64925.1 - 5.4 6.4 32.5 3.8 6.9 6.4 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family GATase PF00117.23 ESS64926.1 - 1.1e-35 122.8 0.0 2.2e-35 121.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 ESS64926.1 - 1.8e-26 91.6 0.0 4.6e-16 58.2 0.0 2.8 2 1 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.8 ESS64926.1 - 1.4e-13 50.7 0.0 1.4e-12 47.5 0.0 2.7 2 1 1 3 3 3 1 Peptidase C26 NAD_synthase PF02540.12 ESS64926.1 - 1.5e-08 33.8 0.0 0.00016 20.6 0.0 2.2 2 0 0 2 2 2 2 NAD synthase QueC PF06508.8 ESS64926.1 - 4.4e-05 22.8 0.0 0.00049 19.4 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 ESS64926.1 - 0.00053 19.4 0.0 0.0015 18.0 0.0 1.7 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.14 ESS64926.1 - 0.00072 18.7 0.0 0.001 18.1 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 ESS64926.1 - 0.004 16.6 0.0 0.0077 15.7 0.0 1.5 1 1 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.15 ESS64926.1 - 0.0056 16.2 0.0 0.035 13.6 0.0 2.0 2 0 0 2 2 2 1 PP-loop family PAPS_reduct PF01507.14 ESS64926.1 - 0.0078 16.0 0.0 0.022 14.5 0.0 1.7 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family tRNA_Me_trans PF03054.11 ESS64926.1 - 0.018 13.6 0.0 0.042 12.4 0.1 1.6 2 0 0 2 2 2 0 tRNA methyl transferase GATase_3 PF07685.9 ESS64926.1 - 0.14 11.7 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DIRP PF06584.8 ESS64927.1 - 0.022 14.6 0.2 0.047 13.5 0.2 1.5 1 0 0 1 1 1 0 DIRP Pox_MCEL PF03291.11 ESS64929.1 - 1.6e-41 142.2 0.0 2e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme mRNA_cap_C PF03919.10 ESS64929.1 - 1.5e-10 41.3 0.1 3.9e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain mRNA_cap_enzyme PF01331.14 ESS64929.1 - 2.4e-10 40.4 0.0 1.9e-05 24.4 0.0 3.1 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain Methyltransf_11 PF08241.7 ESS64929.1 - 0.01 16.3 0.0 0.063 13.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS64929.1 - 0.011 16.1 0.1 0.034 14.4 0.1 2.0 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESS64929.1 - 0.012 15.6 0.1 0.036 14.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESS64929.1 - 0.037 14.5 0.0 0.3 11.5 0.0 2.6 2 1 0 2 2 1 0 Methyltransferase domain Sec23_trunk PF04811.10 ESS64929.1 - 0.052 12.9 0.2 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Sec23/Sec24 trunk domain Methyltransf_31 PF13847.1 ESS64929.1 - 0.066 12.8 0.0 10 5.6 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain DNA_ligase_A_M PF01068.16 ESS64929.1 - 0.075 12.3 0.0 15 4.8 0.0 2.7 2 1 0 2 2 2 0 ATP dependent DNA ligase domain Methyltransf_18 PF12847.2 ESS64929.1 - 0.13 12.8 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CTDII PF01556.13 ESS64930.1 - 2.1e-26 91.6 0.0 3e-22 78.2 0.0 3.7 4 0 0 4 4 4 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESS64930.1 - 3.2e-14 52.7 14.1 6e-14 51.8 9.8 1.5 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.1 ESS64930.1 - 0.0071 16.6 2.6 2 8.7 0.1 2.6 2 0 0 2 2 2 2 Cytochrome c3 Prim_Zn_Ribbon PF08273.7 ESS64930.1 - 0.025 14.6 3.6 0.025 14.6 2.5 3.1 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase HypA PF01155.14 ESS64930.1 - 0.53 9.9 8.9 3 7.5 0.4 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Cytochrome_C7 PF14522.1 ESS64930.1 - 4.6 6.9 9.2 37 4.0 6.5 2.3 1 1 0 1 1 1 0 Cytochrome c7 HHH_5 PF14520.1 ESS64931.1 - 3.8e-05 23.7 0.0 8.2e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.18 ESS64931.1 - 0.00016 21.2 0.0 0.00028 20.4 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.2 ESS64931.1 - 0.0014 18.4 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif R3H PF01424.17 ESS64932.1 - 4e-11 42.4 0.0 7.1e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 ESS64932.1 - 8.7e-11 41.5 205.6 0.00023 21.0 6.2 14.9 13 1 1 14 14 14 9 NF-X1 type zinc finger SET PF00856.23 ESS64934.1 - 0.0001 22.6 0.0 0.00018 21.8 0.0 1.4 1 0 0 1 1 1 1 SET domain FF PF01846.14 ESS64934.1 - 0.064 13.2 0.1 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 FF domain Herpes_UL21 PF03252.8 ESS64935.1 - 0.02 13.3 0.5 0.043 12.2 0.4 1.7 1 1 0 1 1 1 0 Herpesvirus UL21 PP1c_bdg PF10488.4 ESS64935.1 - 0.13 11.4 0.3 0.19 10.8 0.2 1.3 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region SET PF00856.23 ESS64937.1 - 2.1e-13 50.9 0.0 1.9e-12 47.8 0.0 2.5 2 1 0 2 2 2 1 SET domain DUF3177 PF11375.3 ESS64938.1 - 0.0098 15.3 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3177) DDE_Tnp_1_assoc PF13808.1 ESS64938.1 - 0.054 13.1 0.1 4.6 6.9 0.0 2.8 3 0 0 3 3 3 0 DDE_Tnp_1-associated Herpes_UL33 PF03581.8 ESS64941.1 - 0.005 16.7 0.0 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 Herpesvirus UL33-like protein GlcNAc PF11397.3 ESS64941.1 - 0.12 11.4 0.3 0.17 10.9 0.2 1.2 1 0 0 1 1 1 0 Glycosyltransferase (GlcNAc) DUF3619 PF12279.3 ESS64941.1 - 0.66 10.0 4.5 0.53 10.3 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3619) GvpL_GvpF PF06386.6 ESS64941.1 - 0.8 9.2 4.8 1 8.8 3.4 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF MutS_V PF00488.16 ESS64944.1 - 7.5e-83 277.5 0.0 1.2e-82 276.8 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESS64944.1 - 3.5e-31 108.5 1.9 7.6e-31 107.4 1.3 1.6 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 ESS64944.1 - 5.9e-21 74.4 2.2 1.3e-20 73.3 1.5 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.1 ESS64944.1 - 4.2 7.6 5.5 7.9 6.7 0.1 2.6 3 0 0 3 3 3 0 AAA domain Abhydrolase_5 PF12695.2 ESS64945.1 - 1.8e-22 79.6 0.0 2.4e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS64945.1 - 3.8e-16 59.6 0.0 4.9e-10 39.6 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS64945.1 - 1e-09 38.2 0.1 1e-06 28.4 0.0 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ESS64945.1 - 1.9e-05 24.2 2.4 0.0068 15.8 0.7 3.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 ESS64945.1 - 7.9e-05 22.4 0.1 0.00017 21.3 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Peptidase_S9 PF00326.16 ESS64945.1 - 0.00061 19.0 0.0 0.14 11.3 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.13 ESS64945.1 - 0.0015 17.8 0.0 0.0065 15.7 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 ESS64945.1 - 0.028 13.9 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold FSH1 PF03959.8 ESS64945.1 - 0.051 13.0 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Esterase PF00756.15 ESS64945.1 - 0.06 12.7 0.0 0.092 12.1 0.0 1.5 2 0 0 2 2 2 0 Putative esterase C8 PF08742.6 ESS64945.1 - 0.08 13.2 1.9 5.1 7.4 0.6 2.6 2 0 0 2 2 2 0 C8 domain Zn_clus PF00172.13 ESS64947.1 - 0.12 12.3 3.4 0.22 11.4 2.4 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.27 ESS64948.1 - 2.1e-15 55.9 0.2 5.8e-09 35.4 0.1 3.4 2 0 0 2 2 2 2 WD domain, G-beta repeat HSP90 PF00183.13 ESS64949.1 - 1.6e-259 861.7 31.5 2.6e-259 861.0 21.8 1.3 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.1 ESS64949.1 - 9.4e-12 44.7 0.1 9.4e-12 44.7 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESS64949.1 - 1.3e-11 44.1 0.0 2.6e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ABC_tran PF00005.22 ESS64950.1 - 1.6e-40 138.5 1.2 3e-21 76.1 0.0 3.7 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 ESS64950.1 - 2.1e-18 67.3 0.1 0.00024 21.1 0.0 4.3 3 1 0 4 4 4 4 AAA domain SMC_N PF02463.14 ESS64950.1 - 2.2e-12 46.6 0.0 3.4e-06 26.4 0.0 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 ESS64950.1 - 9e-07 28.2 0.0 9e-05 21.7 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESS64950.1 - 6.1e-06 27.0 3.1 0.088 13.6 0.0 4.3 4 1 0 4 4 4 2 AAA domain SbcCD_C PF13558.1 ESS64950.1 - 1e-05 25.3 0.1 0.005 16.7 0.0 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 ESS64950.1 - 0.00011 21.7 0.2 0.09 12.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_tran_2 PF12848.2 ESS64950.1 - 0.00042 20.0 21.4 0.001 18.8 1.0 3.5 3 0 0 3 3 3 2 ABC transporter AAA_15 PF13175.1 ESS64950.1 - 0.0017 17.4 2.2 1.7 7.6 0.0 4.3 4 1 1 5 5 5 1 AAA ATPase domain RNA_helicase PF00910.17 ESS64950.1 - 0.0019 18.3 0.0 0.31 11.2 0.0 2.6 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.18 ESS64950.1 - 0.0031 17.4 0.2 0.14 12.1 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESS64950.1 - 0.0031 17.5 0.5 0.44 10.5 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 ESS64950.1 - 0.0035 17.5 5.3 0.63 10.2 0.1 4.1 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) Miro PF08477.8 ESS64950.1 - 0.0056 17.1 0.9 0.43 11.0 0.0 3.3 3 1 0 3 3 3 1 Miro-like protein AAA_14 PF13173.1 ESS64950.1 - 0.009 15.9 0.0 4.6 7.1 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.1 ESS64950.1 - 0.014 15.5 0.7 0.99 9.5 0.1 3.0 3 1 0 3 3 2 0 AAA domain AAA_33 PF13671.1 ESS64950.1 - 0.015 15.1 0.5 0.72 9.7 0.0 3.2 4 1 0 4 4 3 0 AAA domain AAA_28 PF13521.1 ESS64950.1 - 0.016 15.1 3.8 5.1 7.0 0.0 3.7 3 1 0 3 3 3 0 AAA domain AAA_10 PF12846.2 ESS64950.1 - 0.042 13.2 0.0 5.1 6.4 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain AAA_5 PF07728.9 ESS64950.1 - 0.052 13.2 0.0 4.2 7.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 ESS64950.1 - 0.062 12.9 0.0 3.2 7.3 0.0 3.0 3 0 0 3 3 3 0 NACHT domain AAA_18 PF13238.1 ESS64950.1 - 0.082 13.2 9.1 8.1 6.7 0.0 4.1 4 0 0 4 4 4 0 AAA domain Dynamin_N PF00350.18 ESS64950.1 - 0.64 9.8 6.3 4 7.2 0.9 3.3 3 1 0 3 3 2 0 Dynamin family FtsK_SpoIIIE PF01580.13 ESS64950.1 - 1.1 8.6 6.8 14 5.0 2.6 3.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_23 PF13476.1 ESS64950.1 - 3.9 7.7 26.5 3.2 8.0 0.0 3.7 4 1 0 4 4 3 0 AAA domain Pkinase PF00069.20 ESS64951.1 - 6.8e-48 163.0 0.0 2.2e-37 128.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64951.1 - 8.9e-28 97.0 0.4 5.5e-20 71.5 0.2 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESS64951.1 - 0.22 10.2 0.2 0.32 9.7 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PSI PF01437.20 ESS64953.1 - 0.0022 18.0 15.3 0.0022 18.0 10.6 4.4 4 1 0 4 4 4 1 Plexin repeat Mpv17_PMP22 PF04117.7 ESS64954.1 - 7.2e-15 54.3 0.6 7.2e-15 54.3 0.4 2.3 3 0 0 3 3 3 1 Mpv17 / PMP22 family RRM_1 PF00076.17 ESS64955.1 - 2.6e-09 36.5 0.0 4.5e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS64955.1 - 6.2e-08 32.5 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESS64955.1 - 3.2e-05 23.7 0.1 6e-05 22.8 0.1 1.5 1 1 0 1 1 1 1 RNA binding motif RRM_5 PF13893.1 ESS64955.1 - 3.5e-05 23.5 0.0 6.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESS64955.1 - 0.0044 16.7 0.0 0.0081 15.8 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 NID PF07292.8 ESS64955.1 - 0.094 12.7 0.1 0.26 11.3 0.0 1.7 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) GST_N_3 PF13417.1 ESS64956.1 - 3e-35 120.2 0.1 5.9e-18 64.8 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESS64956.1 - 4.8e-25 87.3 0.1 2.7e-14 52.8 0.0 2.7 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESS64956.1 - 2.9e-15 56.1 0.0 2.1e-09 37.4 0.0 2.7 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESS64956.1 - 4.9e-13 48.7 1.2 1.1e-05 25.2 0.0 3.0 3 0 0 3 3 3 2 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.19 ESS64956.1 - 6.3e-09 35.6 0.2 3.9e-08 33.1 0.2 2.1 2 0 0 2 2 2 1 Glutaredoxin GST_C PF00043.20 ESS64956.1 - 2.5e-06 27.3 0.2 0.019 14.9 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESS64956.1 - 3.4e-06 27.4 0.0 0.0031 17.9 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain Rpr2 PF04032.11 ESS64956.1 - 0.047 13.5 0.2 0.83 9.5 0.0 2.2 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain A_deamin PF02137.13 ESS64957.1 - 4.7e-46 157.6 0.0 5.7e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain CAP_N PF01213.14 ESS64959.1 - 1.9 7.7 6.0 3.2 6.9 4.2 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.6 ESS64959.1 - 5.7 6.2 14.4 27 4.0 8.7 2.4 2 1 0 2 2 2 0 Mitochondrial fission regulator zf-DHHC PF01529.15 ESS64961.1 - 4.5e-30 104.3 5.4 6.1e-30 103.8 3.7 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase HAP2-GCS1 PF10699.4 ESS64962.1 - 3.2e-20 71.8 0.4 1.6e-19 69.5 0.1 2.2 2 0 0 2 2 2 1 Male gamete fusion factor Peptidase_M14 PF00246.19 ESS64964.1 - 1.1e-24 87.5 0.0 1.9e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESS64964.1 - 0.04 12.8 0.0 0.063 12.1 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family BUD22 PF09073.5 ESS64964.1 - 0.044 12.8 15.9 0.086 11.8 11.0 1.4 1 0 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.7 ESS64964.1 - 0.13 11.9 17.2 0.27 10.8 11.9 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Daxx PF03344.10 ESS64964.1 - 0.85 8.0 13.8 1.7 7.0 9.6 1.4 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 ESS64964.1 - 1.5 6.6 23.9 2.5 5.8 16.6 1.3 1 0 0 1 1 1 0 Nop14-like family Nop PF01798.13 ESS64967.1 - 1.3e-21 76.4 0.1 3.3e-21 75.1 0.0 1.6 2 0 0 2 2 2 1 Putative snoRNA binding domain NOSIC PF08060.8 ESS64967.1 - 5.3e-13 48.5 0.1 1.2e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain CEP19 PF14933.1 ESS64968.1 - 1.9e-46 158.2 0.1 4e-46 157.2 0.1 1.5 1 0 0 1 1 1 1 CEP19-like protein EF-hand_7 PF13499.1 ESS64968.1 - 0.055 13.6 0.7 3.8 7.7 0.0 3.2 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.27 ESS64968.1 - 0.29 10.5 1.3 1.9 7.9 0.0 2.8 3 0 0 3 3 3 0 EF hand Fe_hyd_lg_C PF02906.9 ESS64971.1 - 1.5e-69 234.3 0.0 2e-69 234.0 0.0 1.1 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain PDZ_2 PF13180.1 ESS64972.1 - 7.9e-06 25.6 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 ESS64972.1 - 0.016 15.3 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Ank_2 PF12796.2 ESS64973.1 - 0.0001 22.5 0.0 0.00023 21.4 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESS64973.1 - 0.0011 18.6 0.1 0.0042 16.8 0.0 2.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 ESS64973.1 - 0.045 14.0 0.1 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeat FYDLN_acid PF09538.5 ESS64973.1 - 0.35 11.4 18.9 0.18 12.3 8.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Cytidylate_kin PF02224.13 ESS64974.1 - 0.023 14.1 1.6 0.058 12.8 1.1 1.6 1 0 0 1 1 1 0 Cytidylate kinase DUF3752 PF12572.3 ESS64974.1 - 2.8 8.0 8.0 2.9 7.9 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3752) PTPLA PF04387.9 ESS64976.1 - 2.1e-24 85.7 1.8 2.1e-24 85.7 1.2 1.6 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA DUF3945 PF13101.1 ESS64977.1 - 0.077 12.3 0.1 0.44 9.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) DUF2385 PF09539.5 ESS64978.1 - 0.01 16.1 0.1 0.02 15.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) DUF883 PF05957.8 ESS64978.1 - 0.016 15.6 2.0 0.098 13.0 0.0 2.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Tetraspannin PF00335.15 ESS64979.1 - 7.9e-22 77.6 10.3 1.1e-21 77.1 7.1 1.2 1 0 0 1 1 1 1 Tetraspanin family YjgP_YjgQ PF03739.9 ESS64979.1 - 2.8e-05 23.0 0.1 2.8e-05 23.0 0.1 1.4 2 0 0 2 2 2 1 Predicted permease YjgP/YjgQ family PIG-F PF06699.6 ESS64979.1 - 0.0053 16.7 5.5 0.01 15.7 3.8 1.4 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F CD20 PF04103.10 ESS64979.1 - 0.0077 16.1 5.9 0.0077 16.1 4.1 2.3 2 1 0 3 3 3 1 CD20-like family Claudin_2 PF13903.1 ESS64979.1 - 4.6 6.9 14.8 24 4.5 8.3 2.8 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DSPc PF00782.15 ESS64981.1 - 1.5e-30 105.5 0.1 2.1e-30 105.0 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS64981.1 - 0.00054 19.3 0.0 0.00063 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.7 ESS64981.1 - 0.0018 17.2 0.0 0.0023 16.8 0.0 1.1 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase PTPlike_phytase PF14566.1 ESS64981.1 - 0.0041 17.1 0.0 0.009 16.0 0.0 1.5 1 1 0 1 1 1 1 Inositol hexakisphosphate TFIIIC_sub6 PF10419.4 ESS64981.1 - 0.0052 16.2 0.0 0.0098 15.3 0.0 1.4 1 0 0 1 1 1 1 TFIIIC subunit RHSP PF07999.6 ESS64984.1 - 7.5e-116 387.2 0.2 7.5e-116 387.2 0.2 1.9 2 0 0 2 2 2 1 Retrotransposon hot spot protein Syja_N PF02383.13 ESS64985.1 - 1.2e-20 73.5 0.0 4.8e-20 71.5 0.0 1.9 2 1 0 2 2 2 1 SacI homology domain Glutaredoxin PF00462.19 ESS64986.1 - 4.8e-10 39.2 0.4 1.1e-09 38.1 0.3 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 ESS64986.1 - 1.1e-07 31.9 0.0 2.9e-07 30.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESS64986.1 - 0.00015 22.2 0.0 0.00028 21.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Prok-RING_4 PF14447.1 ESS64986.1 - 0.025 14.1 0.4 0.072 12.6 0.3 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 SPX PF03105.14 ESS64987.1 - 6.3 6.4 6.7 14 5.3 4.7 1.6 1 1 0 1 1 1 0 SPX domain Pol_alpha_B_N PF08418.5 ESS64988.1 - 0.029 13.8 0.1 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF3816 PF12822.2 ESS64989.1 - 0.017 15.0 1.8 0.019 14.8 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) Vac14_Fig4_bd PF11916.3 ESS64990.1 - 9.5e-57 191.0 5.8 9.5e-57 191.0 4.0 2.9 3 1 0 3 3 3 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 ESS64990.1 - 2.7e-08 34.0 0.2 1.9e-05 24.9 0.0 3.3 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.1 ESS64990.1 - 0.0016 18.6 0.2 5.3 7.4 0.0 4.1 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.17 ESS64990.1 - 0.0019 18.1 3.9 1.4 9.1 0.1 4.8 5 0 0 5 5 5 2 HEAT repeat Kelch_5 PF13854.1 ESS64991.1 - 1.2e-08 34.7 1.5 0.035 14.0 0.0 4.5 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESS64991.1 - 2.1e-08 33.9 3.0 0.28 11.4 0.1 6.0 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 ESS64991.1 - 5.2e-06 26.1 12.1 0.017 14.8 0.1 5.2 4 2 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESS64991.1 - 0.0095 15.6 3.6 35 4.3 0.0 4.9 5 0 0 5 5 5 0 Kelch motif Kelch_1 PF01344.20 ESS64991.1 - 0.0097 15.4 1.8 1.7 8.2 0.0 4.4 6 0 0 6 6 6 1 Kelch motif Kelch_3 PF13415.1 ESS64991.1 - 0.018 15.2 4.4 0.19 11.9 0.0 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain C2 PF00168.25 ESS64992.1 - 0.0038 17.0 0.0 0.052 13.3 0.0 2.6 2 1 0 2 2 2 1 C2 domain DUF3832 PF12909.2 ESS64993.1 - 0.0062 16.5 0.0 0.027 14.5 0.0 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3832) WD40 PF00400.27 ESS64994.1 - 3.1e-15 55.3 12.7 0.00037 20.2 0.0 9.2 10 0 0 10 10 10 4 WD domain, G-beta repeat DUF4170 PF13773.1 ESS64994.1 - 0.16 11.8 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4170) Pkinase PF00069.20 ESS64996.1 - 3.3e-65 219.8 0.0 4.9e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS64996.1 - 3e-44 151.0 0.0 4.5e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS64996.1 - 3e-09 36.2 0.0 4.7e-08 32.3 0.0 2.1 1 1 1 2 2 2 1 Kinase-like EMP24_GP25L PF01105.19 ESS64998.1 - 1.3e-19 70.6 0.0 1.6e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD tRNA-synt_1b PF00579.20 ESS65000.1 - 1.3e-55 188.6 0.0 4.7e-52 176.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Gag_p10 PF02337.12 ESS65000.1 - 0.2 11.3 0.7 1 9.1 0.5 2.3 1 1 0 1 1 1 0 Retroviral GAG p10 protein PX PF00787.19 ESS65002.1 - 2.8e-07 30.3 0.2 5.4e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 PX domain HSP20 PF00011.16 ESS65002.1 - 0.071 12.9 0.0 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Hsp20/alpha crystallin family DnaJ PF00226.26 ESS65003.1 - 1e-21 76.3 4.7 1e-21 76.3 3.2 3.0 3 0 0 3 3 3 1 DnaJ domain TPR_11 PF13414.1 ESS65003.1 - 3.7e-19 68.1 19.9 1.2e-09 37.6 0.6 5.1 4 1 1 5 5 5 5 TPR repeat TPR_19 PF14559.1 ESS65003.1 - 9.3e-15 54.7 26.5 7.5e-05 22.9 4.4 5.8 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESS65003.1 - 5e-11 41.6 25.0 0.04 13.8 0.1 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65003.1 - 6.5e-11 42.5 30.8 0.0057 17.2 1.8 5.9 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS65003.1 - 3.2e-07 30.3 33.8 0.018 15.6 2.3 7.5 5 3 3 8 8 7 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65003.1 - 7.2e-06 25.3 18.3 0.15 11.7 0.1 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESS65003.1 - 0.00033 20.4 29.1 0.022 14.6 0.3 5.7 4 2 2 6 6 6 3 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESS65003.1 - 0.0012 19.0 9.6 0.0026 18.0 0.8 3.3 2 1 1 3 3 3 1 Alkyl sulfatase dimerisation DUF3818 PF12825.2 ESS65003.1 - 0.004 15.8 3.4 0.24 10.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) TPR_20 PF14561.1 ESS65003.1 - 0.059 13.4 16.7 0.86 9.7 0.4 5.1 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65003.1 - 0.15 11.8 8.5 1.3 8.9 0.1 4.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS65003.1 - 0.36 11.3 20.1 4.4 7.9 0.3 6.5 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS65003.1 - 0.68 9.9 0.0 0.68 9.9 0.0 6.0 5 2 2 7 7 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS65003.1 - 0.75 10.1 0.0 0.75 10.1 0.0 5.4 8 1 0 8 8 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS65003.1 - 9.2 6.2 17.1 1 9.2 0.2 5.4 5 2 2 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat SHMT PF00464.14 ESS65004.1 - 1.4e-169 563.7 0.0 1.7e-169 563.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 ESS65004.1 - 0.044 12.9 0.0 0.075 12.1 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase YjbE PF11106.3 ESS65005.1 - 0.094 12.6 8.5 0.21 11.5 5.9 1.6 1 0 0 1 1 1 0 Exopolysaccharide production protein YjbE Pkinase PF00069.20 ESS65006.1 - 8e-71 238.2 0.0 1.1e-70 237.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65006.1 - 1.5e-42 145.5 0.0 1.9e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65006.1 - 4.7e-07 29.0 0.0 0.021 13.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.6 ESS65006.1 - 0.029 13.2 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 ESS65006.1 - 0.033 13.9 0.0 0.087 12.5 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESS65006.1 - 0.093 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family WXG100 PF06013.7 ESS65007.1 - 0.026 14.5 0.7 0.026 14.5 0.5 2.9 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Spc24 PF08286.6 ESS65007.1 - 0.86 9.3 12.2 2.3 7.9 1.2 3.5 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.15 ESS65007.1 - 0.9 9.3 8.9 0.085 12.6 0.8 3.1 2 1 0 2 2 2 0 Prefoldin subunit F420_oxidored PF03807.12 ESS65008.1 - 4.5e-06 27.0 0.0 9.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 ESS65008.1 - 1.8e-05 24.7 0.1 4.9e-05 23.2 0.1 1.8 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.1 ESS65008.1 - 0.00031 20.9 0.0 0.00082 19.5 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Saccharop_dh PF03435.13 ESS65008.1 - 0.004 16.2 0.2 0.0061 15.5 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 ESS65008.1 - 0.0098 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 ESS65008.1 - 0.085 12.8 0.3 0.2 11.6 0.1 1.7 2 0 0 2 2 2 0 NADH(P)-binding Ribosomal_S27 PF01599.14 ESS65009.1 - 1.2e-21 76.2 2.4 1.2e-21 76.2 1.7 1.6 2 0 0 2 2 2 1 Ribosomal protein S27a IBR PF01485.16 ESS65009.1 - 0.0024 17.6 0.4 0.0034 17.2 0.2 1.3 1 0 0 1 1 1 1 IBR domain RRM_1 PF00076.17 ESS65013.1 - 2.4e-16 59.1 0.0 3.8e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS65013.1 - 2.5e-10 40.1 0.0 4.8e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS65013.1 - 4.9e-07 29.4 0.0 7.6e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Snapin_Pallidin PF14712.1 ESS65014.1 - 0.0019 18.4 4.4 0.0019 18.4 3.1 5.6 5 4 0 5 5 5 1 Snapin/Pallidin Orthopox_F14 PF06076.7 ESS65014.1 - 0.015 15.3 0.5 0.23 11.5 0.0 2.7 2 0 0 2 2 2 0 Orthopoxvirus F14 protein Med2 PF11214.3 ESS65014.1 - 0.025 14.5 1.1 0.025 14.5 0.8 4.1 3 1 1 4 4 4 0 Mediator complex subunit 2 Surfac_D-trimer PF09006.6 ESS65014.1 - 0.039 13.6 0.4 0.5 10.1 0.0 2.9 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation HGD-D PF06050.8 ESS65014.1 - 0.054 12.3 1.8 0.79 8.4 0.1 2.6 1 1 1 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component Reo_sigmaC PF04582.7 ESS65014.1 - 0.13 11.3 13.8 0.16 11.0 0.0 4.6 4 2 1 5 5 5 0 Reovirus sigma C capsid protein DUF4391 PF14335.1 ESS65014.1 - 7.1 5.9 16.3 0.053 12.9 3.8 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4391) Cauli_AT PF03233.8 ESS65014.1 - 9.1 5.9 13.0 3.4 7.3 1.7 4.0 4 0 0 4 4 4 0 Aphid transmission protein Nsp1_C PF05064.8 ESS65014.1 - 9.7 5.8 16.0 1.1 8.8 4.4 3.8 4 0 0 4 4 4 0 Nsp1-like C-terminal region DUF3054 PF11255.3 ESS65015.1 - 0.09 12.6 0.3 0.17 11.7 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3054) PSS PF03034.10 ESS65016.1 - 4.3e-110 367.5 4.7 7.9e-110 366.6 3.3 1.4 1 0 0 1 1 1 1 Phosphatidyl serine synthase Carb_kinase PF01256.12 ESS65017.1 - 2.9e-51 174.0 1.6 6.1e-50 169.7 1.1 2.3 1 1 0 1 1 1 1 Carbohydrate kinase YjeF_N PF03853.10 ESS65017.1 - 1.2e-45 155.1 0.2 1e-44 152.0 0.0 2.3 2 0 0 2 2 2 1 YjeF-related protein N-terminus Phos_pyr_kin PF08543.7 ESS65017.1 - 8.3e-05 21.8 0.0 0.00015 21.0 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Ham1p_like PF01725.11 ESS65017.1 - 0.05 12.9 0.0 0.28 10.5 0.0 2.0 2 0 0 2 2 2 0 Ham1 family PAP_central PF04928.12 ESS65018.1 - 4.1e-84 281.3 0.0 5.8e-84 280.8 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 ESS65018.1 - 1.3e-24 86.4 0.0 2.4e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 ESS65018.1 - 0.00058 20.1 0.0 0.0015 18.7 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain FYVE PF01363.16 ESS65019.1 - 2.8e-15 55.9 14.4 2.8e-15 55.9 10.0 2.5 2 1 0 2 2 2 1 FYVE zinc finger Ras PF00071.17 ESS65019.1 - 3.3e-07 29.8 0.0 6e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS65019.1 - 8.1e-05 23.0 0.0 0.00018 22.0 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein F-box-like PF12937.2 ESS65019.1 - 0.00027 20.6 0.3 0.00062 19.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESS65019.1 - 0.0074 15.9 0.2 0.019 14.5 0.2 1.7 1 0 0 1 1 1 1 F-box domain NACHT PF05729.7 ESS65019.1 - 0.08 12.5 0.0 0.21 11.2 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 ESS65019.1 - 0.088 12.9 0.1 0.3 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 ESS65019.1 - 0.091 12.7 0.5 1.8 8.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain Pro_racemase PF05544.6 ESS65020.1 - 1.9e-135 450.8 0.1 2.2e-135 450.6 0.1 1.0 1 0 0 1 1 1 1 Proline racemase PhzC-PhzF PF02567.11 ESS65020.1 - 0.0068 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein CSD PF00313.17 ESS65021.1 - 6.2e-13 48.3 1.0 8.8e-07 28.6 0.5 4.6 5 0 0 5 5 5 2 'Cold-shock' DNA-binding domain S1-like PF14444.1 ESS65021.1 - 0.024 14.3 1.1 0.049 13.3 0.2 1.9 2 0 0 2 2 2 0 S1-like WD40 PF00400.27 ESS65022.1 - 2.8e-05 23.8 17.7 0.5 10.3 0.2 5.8 7 0 0 7 7 7 3 WD domain, G-beta repeat Radial_spoke_3 PF06098.6 ESS65022.1 - 0.97 8.3 2.8 1.5 7.7 1.9 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 EBP50_C-term PF09007.6 ESS65023.1 - 0.011 15.5 0.2 0.037 13.8 0.1 1.9 1 0 0 1 1 1 0 EBP50, C-terminal Peripla_BP_6 PF13458.1 ESS65025.1 - 9.6e-12 44.8 0.8 5.4e-10 39.1 0.2 2.6 2 1 0 2 2 2 2 Periplasmic binding protein Guanylate_cyc PF00211.15 ESS65026.1 - 3e-06 26.7 0.0 4e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain EmrE PF13536.1 ESS65027.1 - 5.4 7.2 18.5 0.056 13.6 6.5 2.3 2 1 1 3 3 3 0 Multidrug resistance efflux transporter ERG4_ERG24 PF01222.12 ESS65028.1 - 4.9e-129 430.6 6.7 5.8e-129 430.3 4.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 ESS65028.1 - 1.2e-08 34.5 0.2 3.9e-08 32.8 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 ESS65028.1 - 4.9e-05 23.3 0.0 4.9e-05 23.3 0.0 2.4 3 0 0 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.9 ESS65028.1 - 0.0017 18.5 0.0 0.0058 16.8 0.0 1.9 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Actin PF00022.14 ESS65030.1 - 5.2e-120 400.4 0.0 6e-120 400.2 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESS65030.1 - 0.002 16.7 0.0 0.11 11.0 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein CENP-Q PF13094.1 ESS65031.1 - 2.9 7.8 8.6 5.9 6.8 3.0 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4398 PF14346.1 ESS65034.1 - 0.47 10.5 17.6 0.91 9.6 12.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) Formyl_trans_N PF00551.14 ESS65035.1 - 2.8e-18 66.0 0.0 6.6e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase DEAD PF00270.24 ESS65036.1 - 6.1e-43 146.2 0.0 1.1e-42 145.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65036.1 - 2.5e-21 75.3 0.5 5.6e-21 74.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESS65036.1 - 9.3e-13 47.5 0.1 2.1e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESS65036.1 - 0.0004 20.2 0.0 0.00088 19.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RasGAP_C PF03836.10 ESS65038.1 - 0.014 15.0 6.4 0.034 13.8 2.7 2.1 1 1 1 2 2 2 0 RasGAP C-terminus DcpS_C PF11969.3 ESS65038.1 - 0.1 12.8 2.5 0.67 10.2 0.3 2.1 1 1 1 2 2 2 0 Scavenger mRNA decapping enzyme C-term binding DUF2762 PF10960.3 ESS65038.1 - 0.16 11.6 3.6 0.3 10.8 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) GrpE PF01025.14 ESS65038.1 - 0.41 10.1 8.6 2.4 7.7 3.7 2.2 1 1 1 2 2 2 0 GrpE DUF342 PF03961.8 ESS65038.1 - 0.75 8.1 9.2 0.88 7.9 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CorA PF01544.13 ESS65038.1 - 1.5 7.7 5.6 2.2 7.2 3.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HAUS6_N PF14661.1 ESS65038.1 - 5.4 6.2 8.8 1.2 8.3 3.3 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Pox_A_type_inc PF04508.7 ESS65038.1 - 6.2 6.8 7.9 3 7.8 1.3 3.0 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat SlyX PF04102.7 ESS65038.1 - 7.9 6.9 7.9 2.1 8.7 0.1 2.9 3 1 0 3 3 3 0 SlyX HAP1_N PF04849.8 ESS65039.1 - 6e-05 22.1 7.4 0.015 14.3 1.1 2.2 1 1 1 2 2 2 2 HAP1 N-terminal conserved region ERM PF00769.14 ESS65039.1 - 0.034 13.6 6.9 0.072 12.6 4.8 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Tricorn_PDZ PF14685.1 ESS65039.1 - 0.062 13.1 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Tricorn protease PDZ domain Spc7 PF08317.6 ESS65039.1 - 0.067 11.8 2.9 0.11 11.0 1.2 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.8 ESS65039.1 - 0.072 13.4 7.8 0.13 12.6 2.8 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF972) HOOK PF05622.7 ESS65039.1 - 0.12 10.1 10.5 0.014 13.2 2.4 2.1 2 0 0 2 2 2 0 HOOK protein Atg14 PF10186.4 ESS65039.1 - 0.17 10.8 5.1 0.36 9.7 3.5 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Mnd1 PF03962.10 ESS65039.1 - 0.2 11.3 3.9 0.39 10.3 2.7 1.4 1 0 0 1 1 1 0 Mnd1 family bZIP_1 PF00170.16 ESS65039.1 - 0.98 9.4 13.8 1 9.3 0.3 4.0 2 1 2 4 4 4 0 bZIP transcription factor TPR_MLP1_2 PF07926.7 ESS65039.1 - 1.3 8.7 8.8 0.8 9.4 1.7 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GTP_EFTU PF00009.22 ESS65040.1 - 2.9e-26 92.0 0.0 4.5e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 ESS65040.1 - 1.6e-19 69.5 0.0 3.1e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 ESS65040.1 - 2e-08 33.9 0.0 4.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Miro PF08477.8 ESS65040.1 - 3.6e-08 33.9 0.0 6.5e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESS65040.1 - 4.4e-07 29.8 0.0 9.1e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_IV PF03764.13 ESS65040.1 - 2.2e-06 27.2 0.0 4.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV Dynamin_N PF00350.18 ESS65040.1 - 4.4e-05 23.3 0.1 0.056 13.2 0.0 2.3 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.5 ESS65040.1 - 0.0028 16.9 0.0 0.0046 16.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 ESS65040.1 - 0.0046 16.3 0.0 0.0079 15.5 0.0 1.3 1 0 0 1 1 1 1 Ras family GTP_EFTU_D2 PF03144.20 ESS65040.1 - 0.017 15.2 0.0 0.049 13.7 0.0 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 2 ATG16 PF08614.6 ESS65042.1 - 0.0071 16.1 7.2 0.0071 16.1 5.0 6.1 1 1 4 5 5 5 1 Autophagy protein 16 (ATG16) Guanylate_cyc PF00211.15 ESS65044.1 - 7.5e-22 77.5 0.0 1.4e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peptidase_S28 PF05577.7 ESS65045.1 - 2.2e-50 171.5 0.1 2.9e-50 171.1 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.15 ESS65045.1 - 0.0057 16.2 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold NTF-like PF14540.1 ESS65046.1 - 0.027 14.1 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase-like HEAT PF02985.17 ESS65047.1 - 9.3e-12 43.9 5.5 0.37 10.9 0.0 7.5 7 0 0 7 7 6 4 HEAT repeat HEAT_EZ PF13513.1 ESS65047.1 - 2.2e-10 40.7 1.4 0.023 15.1 0.0 8.1 8 0 0 8 8 8 1 HEAT-like repeat HEAT_2 PF13646.1 ESS65047.1 - 1.7e-09 37.8 0.0 0.0076 16.5 0.0 5.7 6 1 1 7 7 6 3 HEAT repeats Cnd1 PF12717.2 ESS65047.1 - 5.7e-06 26.2 2.0 0.0025 17.6 0.0 4.1 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 ESS65047.1 - 1.2e-05 24.8 6.9 1.2 8.4 0.1 5.8 6 1 2 8 8 8 3 CLASP N terminal Vac14_Fab1_bd PF12755.2 ESS65047.1 - 6.2e-05 23.3 0.5 0.28 11.5 0.1 4.9 3 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region MMS19_N PF14500.1 ESS65047.1 - 0.00038 19.8 0.4 0.039 13.2 0.0 3.5 3 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II CRM1_C PF08767.6 ESS65047.1 - 0.0008 18.4 1.6 0.7 8.7 0.1 2.9 2 0 0 2 2 2 2 CRM1 C terminal Cnd3 PF12719.2 ESS65047.1 - 0.0036 16.3 2.7 0.12 11.3 0.1 2.7 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain DUF2435 PF10363.4 ESS65047.1 - 0.011 15.6 1.2 1.1 9.2 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2435) Pox_polyA_pol_C PF12629.2 ESS65047.1 - 0.094 12.4 0.1 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain RRM_1 PF00076.17 ESS65048.1 - 3.2e-08 33.0 0.0 6.8e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS65048.1 - 1.2e-07 31.5 0.1 3.9e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 ESS65048.1 - 3.3e-05 23.8 0.0 0.00015 21.8 0.0 1.9 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_5 PF13893.1 ESS65048.1 - 0.00032 20.4 0.0 0.00089 19.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DinB_2 PF12867.2 ESS65048.1 - 0.2 11.9 1.9 5.9 7.2 0.2 2.5 1 1 1 2 2 2 0 DinB superfamily PI3_PI4_kinase PF00454.22 ESS65050.1 - 2.4e-16 59.9 0.1 4.6e-16 59.0 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FYVE PF01363.16 ESS65050.1 - 1.3e-10 41.0 7.9 3.8e-10 39.5 5.4 1.9 1 0 0 1 1 1 1 FYVE zinc finger Cas_DxTHG PF09455.5 ESS65050.1 - 0.012 14.8 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family YceG PF02618.11 ESS65050.1 - 0.072 12.1 0.3 0.12 11.3 0.2 1.2 1 0 0 1 1 1 0 YceG-like family Pex2_Pex12 PF04757.9 ESS65050.1 - 0.23 10.8 5.1 2.1 7.7 0.0 2.7 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region Tropomyosin_1 PF12718.2 ESS65052.1 - 0.0013 18.6 22.4 0.0029 17.4 0.4 3.2 3 1 0 3 3 3 1 Tropomyosin like DUF3095 PF11294.3 ESS65052.1 - 0.0085 15.1 1.3 0.014 14.4 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3095) IncA PF04156.9 ESS65052.1 - 0.015 14.9 0.2 0.015 14.9 0.1 3.1 3 1 0 3 3 2 0 IncA protein LCD1 PF09798.4 ESS65052.1 - 0.028 12.4 1.2 0.043 11.8 0.9 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein HALZ PF02183.13 ESS65052.1 - 0.39 10.4 13.8 2.8 7.7 0.0 4.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper CDC37_N PF03234.9 ESS65052.1 - 0.85 9.9 11.9 0.35 11.1 6.2 1.8 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DUF4618 PF15397.1 ESS65052.1 - 1.2 8.4 11.7 3.7 6.8 6.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF972 PF06156.8 ESS65052.1 - 1.5 9.1 22.2 0.28 11.5 2.9 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF972) GAS PF13851.1 ESS65052.1 - 2 7.5 21.5 0.65 9.1 0.7 3.6 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding DUF1843 PF08898.5 ESS65052.1 - 2.6 8.1 8.9 17 5.5 0.1 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF1843) Myosin_tail_1 PF01576.14 ESS65052.1 - 4.8 4.7 23.3 0.27 8.8 11.1 1.9 2 0 0 2 2 2 0 Myosin tail TSC22 PF01166.13 ESS65052.1 - 7.3 6.6 12.4 1.3 9.0 0.0 3.8 4 1 1 5 5 5 0 TSC-22/dip/bun family DivIC PF04977.10 ESS65052.1 - 7.7 6.0 18.7 0.24 10.9 0.1 5.1 3 1 2 5 5 5 0 Septum formation initiator SRR1 PF07985.7 ESS65053.1 - 0.0012 18.6 0.1 0.0069 16.2 0.0 2.1 2 0 0 2 2 2 1 SRR1 Methyltransf_26 PF13659.1 ESS65054.1 - 3.2e-16 59.4 0.0 5.2e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS65054.1 - 0.00011 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS65054.1 - 0.00017 21.0 0.0 0.18 11.1 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase small domain Methyltransf_25 PF13649.1 ESS65054.1 - 0.0036 17.6 0.0 0.0085 16.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS65054.1 - 0.011 16.2 0.0 0.21 12.1 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain DUF938 PF06080.7 ESS65054.1 - 0.03 13.8 0.0 0.74 9.3 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF938) Methyltransf_12 PF08242.7 ESS65054.1 - 0.043 14.2 0.0 0.14 12.6 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ESS65054.1 - 0.065 12.8 0.0 2.5 7.7 0.0 2.4 2 2 0 2 2 2 0 Methyltransferase domain Methyltransf_4 PF02390.12 ESS65054.1 - 0.17 10.9 0.0 3.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase CTP_transf_2 PF01467.21 ESS65056.1 - 1.7e-09 37.9 0.0 5.4e-09 36.2 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase FAD_syn PF06574.7 ESS65056.1 - 0.077 12.6 0.5 0.22 11.1 0.0 1.9 2 0 0 2 2 2 0 FAD synthetase Lzipper-MIP1 PF14389.1 ESS65057.1 - 1.7 8.7 5.4 0.29 11.2 0.2 2.3 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF3456 PF11938.3 ESS65060.1 - 1.3e-10 41.4 0.1 2.1e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Potyvirid-P3 PF13608.1 ESS65060.1 - 0.0046 16.1 0.6 0.0059 15.7 0.4 1.1 1 0 0 1 1 1 1 Protein P3 of Potyviral polyprotein DUF4200 PF13863.1 ESS65061.1 - 1.9e-29 102.1 16.3 1.9e-29 102.1 11.3 5.1 4 1 0 4 4 4 3 Domain of unknown function (DUF4200) DUF367 PF04034.8 ESS65062.1 - 3.6e-44 149.4 0.0 5e-44 148.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 ESS65062.1 - 4.8e-10 38.8 0.0 9.3e-10 37.9 0.0 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Sorting_nexin PF03700.8 ESS65063.1 - 0.081 13.0 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain DDE_Tnp_1_6 PF13751.1 ESS65063.1 - 0.52 10.3 5.9 0.65 10.0 3.7 1.5 1 1 0 1 1 1 0 Transposase DDE domain Endosulfine PF04667.12 ESS65064.1 - 1.6e-07 31.2 0.3 1.7e-07 31.0 0.2 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Amelin PF05111.7 ESS65064.1 - 2.8 6.5 6.3 3.1 6.4 4.3 1.0 1 0 0 1 1 1 0 Ameloblastin precursor (Amelin) PCI_Csn8 PF10075.4 ESS65065.1 - 3.3e-13 49.6 0.0 4.4e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 ESS65065.1 - 1.1e-08 34.8 0.0 1.4e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family CS PF04969.11 ESS65066.1 - 2.7e-06 27.8 0.8 2.7e-06 27.8 0.5 1.6 2 0 0 2 2 2 1 CS domain EMP24_GP25L PF01105.19 ESS65067.1 - 8e-41 139.7 0.0 9.2e-41 139.5 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Complex1_LYR PF05347.10 ESS65068.1 - 1.2e-12 47.4 0.2 2.3e-12 46.5 0.2 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESS65068.1 - 8.2e-12 45.1 0.2 1.5e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Ras PF00071.17 ESS65069.1 - 5.9e-61 204.5 0.4 6.9e-61 204.3 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS65069.1 - 1.4e-18 67.5 0.0 2.4e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS65069.1 - 2.3e-14 53.0 0.1 2.8e-14 52.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESS65069.1 - 1.3e-06 27.7 0.1 1.6e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESS65069.1 - 9.6e-05 21.8 0.2 0.00031 20.2 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESS65069.1 - 0.00021 21.1 0.0 0.00031 20.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESS65069.1 - 0.024 13.8 0.0 0.053 12.7 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESS65069.1 - 0.024 14.7 0.0 0.058 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESS65069.1 - 0.03 13.9 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS65069.1 - 0.033 14.1 0.1 0.053 13.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 ESS65069.1 - 0.12 11.9 0.0 0.31 10.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dpy-30 PF05186.8 ESS65070.1 - 1.8e-05 24.1 0.1 0.022 14.2 0.0 2.2 2 0 0 2 2 2 2 Dpy-30 motif RHSP PF07999.6 ESS65071.1 - 2.2e-109 366.0 0.1 2.2e-109 366.0 0.1 1.6 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS65071.1 - 0.026 14.6 0.0 11 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 ESS65072.1 - 7.4e-34 116.6 0.1 1.7e-33 115.5 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65072.1 - 4.3e-19 68.1 0.0 9.1e-19 67.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESS65072.1 - 1.1e-13 50.5 1.1 7.4e-13 47.8 0.2 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESS65072.1 - 0.00064 19.5 0.0 0.0017 18.2 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESS65072.1 - 0.033 12.9 0.0 0.077 11.7 0.0 1.6 1 0 0 1 1 1 0 SNF2 family N-terminal domain Bowman-Birk_leg PF00228.15 ESS65072.1 - 0.3 10.9 1.8 29 4.5 0.0 2.9 2 0 0 2 2 2 0 Bowman-Birk serine protease inhibitor family V_ATPase_I PF01496.14 ESS65074.1 - 0.0026 15.6 0.1 0.0034 15.3 0.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SSF PF00474.12 ESS65074.1 - 0.061 11.9 0.2 0.092 11.3 0.2 1.2 1 0 0 1 1 1 0 Sodium:solute symporter family Tetraspannin PF00335.15 ESS65074.1 - 0.37 10.0 3.7 0.58 9.3 2.6 1.2 1 0 0 1 1 1 0 Tetraspanin family p450 PF00067.17 ESS65075.1 - 2.6e-59 200.9 0.0 3.4e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.20 ESS65076.1 - 2.8e-70 236.4 0.0 3.9e-70 235.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65076.1 - 1.3e-35 122.7 0.0 1.8e-34 119.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DUF2656 PF10847.3 ESS65076.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2656) RINGv PF12906.2 ESS65077.1 - 2.8e-10 40.0 7.1 6.8e-10 38.8 4.9 1.7 1 0 0 1 1 1 1 RING-variant domain PHD PF00628.24 ESS65077.1 - 1.1 9.0 9.5 0.97 9.1 0.2 2.5 2 0 0 2 2 2 0 PHD-finger zf-RING_4 PF14570.1 ESS65077.1 - 3.7 7.2 7.2 10 5.8 5.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF2622 PF11080.3 ESS65078.1 - 0.02 14.7 0.0 0.034 14.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2622) DUF1700 PF08006.6 ESS65079.1 - 4.2 6.6 6.2 4.3 6.5 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF3671 PF12420.3 ESS65079.1 - 5.4 7.0 12.7 0.53 10.2 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function zf-CCCH PF00642.19 ESS65081.1 - 2.4e-05 23.8 0.6 3.8e-05 23.2 0.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS65081.1 - 0.2 11.6 0.9 0.34 10.9 0.6 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type SET PF00856.23 ESS65082.1 - 5.9e-10 39.6 0.3 4.3e-09 36.8 0.1 2.0 2 0 0 2 2 2 1 SET domain DUF4266 PF14086.1 ESS65083.1 - 1.7 9.1 5.6 2.4 8.7 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) Proteasome PF00227.21 ESS65085.1 - 1.4e-44 151.6 0.1 1.7e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESS65085.1 - 6.2e-11 41.4 0.0 6.2e-11 41.4 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature zf-C3H1 PF10650.4 ESS65085.1 - 0.064 12.7 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 Putative zinc-finger domain zf-CCCH PF00642.19 ESS65086.1 - 0.11 12.1 0.3 0.25 11.0 0.2 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS65086.1 - 0.19 11.7 0.2 0.4 10.7 0.1 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type zf-U1 PF06220.7 ESS65087.1 - 0.0031 17.0 18.0 0.24 11.0 0.2 5.0 5 0 0 5 5 5 3 U1 zinc finger zf-met PF12874.2 ESS65087.1 - 0.045 13.9 0.3 0.045 13.9 0.2 6.8 8 2 0 8 8 8 0 Zinc-finger of C2H2 type AKAP95 PF04988.7 ESS65087.1 - 1.8 8.3 26.7 3.5 7.3 1.3 5.6 2 1 4 6 6 6 0 A-kinase anchoring protein 95 (AKAP95) VIT1 PF01988.14 ESS65088.1 - 1.8e-60 204.0 4.7 2.1e-60 203.8 3.2 1.1 1 0 0 1 1 1 1 VIT family SET PF00856.23 ESS65089.1 - 0.00054 20.3 0.0 0.0013 19.0 0.0 1.6 2 0 0 2 2 2 1 SET domain XPG_I PF00867.13 ESS65090.1 - 3.7e-30 103.8 0.0 7e-30 102.9 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 ESS65090.1 - 1.3e-26 92.7 0.0 3e-26 91.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 ESS65090.1 - 8.5e-05 22.7 0.1 0.00054 20.1 0.0 2.2 2 1 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Sigma70_r1_1 PF03979.9 ESS65090.1 - 0.0007 19.4 0.8 0.0016 18.3 0.6 1.6 1 0 0 1 1 1 1 Sigma-70 factor, region 1.1 5_3_exonuc_N PF02739.11 ESS65090.1 - 0.013 14.8 0.0 0.038 13.3 0.0 1.7 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain XPG_I_2 PF12813.2 ESS65090.1 - 0.024 14.1 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 XPG domain containing SLBP_RNA_bind PF15247.1 ESS65093.1 - 2e-14 53.0 0.0 5e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain Ank PF00023.25 ESS65094.1 - 1e-20 72.3 0.4 3.5e-08 32.8 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.2 ESS65094.1 - 1.5e-19 70.0 0.0 5.4e-10 39.4 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS65094.1 - 1.3e-17 63.4 0.6 9.1e-11 41.6 0.0 4.5 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS65094.1 - 1.3e-15 55.9 0.5 8.3e-05 22.4 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 ESS65094.1 - 4.2e-13 49.4 0.4 5e-05 23.6 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) PUB PF09409.5 ESS65095.1 - 8e-14 51.1 0.0 1.4e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 PUB domain Tubulin PF00091.20 ESS65096.1 - 2.3e-73 246.5 0.0 3.4e-73 246.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESS65096.1 - 1.1e-44 151.5 0.2 1.1e-44 151.5 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESS65096.1 - 2.4e-05 24.3 0.0 8.1e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.1 ESS65096.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Tubulin like EF-hand_1 PF00036.27 ESS65097.1 - 0.052 12.8 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 ESS65097.1 - 0.13 12.1 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_6 PF13405.1 ESS65098.1 - 2.2e-10 39.5 0.6 0.0079 15.9 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 ESS65098.1 - 5.9e-07 28.3 0.0 0.0052 15.9 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 ESS65098.1 - 5.9e-06 26.3 0.1 0.5 10.5 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 ESS65098.1 - 6.7e-05 22.0 0.0 0.0061 15.8 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 ESS65098.1 - 0.0027 17.3 0.0 0.57 9.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS65099.1 - 3.9e-05 23.1 0.2 0.42 10.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 ESS65099.1 - 0.0071 16.4 0.0 1.6 8.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS65099.1 - 0.058 12.7 0.0 0.69 9.3 0.0 2.4 2 0 0 2 2 2 0 EF hand Dynein_heavy PF03028.10 ESS65100.1 - 4.5e-173 577.0 0.0 1.8e-172 575.0 0.0 2.1 1 1 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 ESS65100.1 - 4.7e-142 474.3 9.0 4.7e-142 474.3 6.2 4.8 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 ESS65100.1 - 1e-120 403.0 3.6 1e-120 403.0 2.5 3.6 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS65100.1 - 1.4e-91 306.1 0.0 2.7e-91 305.2 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESS65100.1 - 1.3e-71 240.6 0.2 2.5e-71 239.7 0.2 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS65100.1 - 8.6e-53 178.5 0.5 3.2e-52 176.6 0.3 2.1 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 ESS65100.1 - 1.8e-40 138.7 0.1 9.2e-40 136.4 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 MT PF12777.2 ESS65100.1 - 5.4e-39 133.9 4.8 1.2e-38 132.7 3.3 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESS65100.1 - 2.3e-14 53.3 0.4 0.0013 18.4 0.0 6.0 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA PF00004.24 ESS65100.1 - 2.1e-06 27.9 0.1 0.026 14.7 0.0 4.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS65100.1 - 9.7e-06 25.6 3.0 1.2 9.1 0.0 5.8 6 0 0 6 6 6 1 AAA ATPase domain AAA_22 PF13401.1 ESS65100.1 - 0.00029 20.9 0.0 6.9 6.8 0.0 4.4 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 ESS65100.1 - 0.027 15.2 3.7 0.16 12.8 0.0 4.5 5 0 0 5 5 4 0 AAA domain 2OG-FeII_Oxy PF03171.15 ESS65102.1 - 8.4e-13 48.4 0.0 1.6e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 ESS65102.1 - 0.00015 22.2 0.0 0.19 12.2 0.0 2.6 2 0 0 2 2 2 2 non-haem dioxygenase in morphine synthesis N-terminal NAD_binding_2 PF03446.10 ESS65103.1 - 7.5e-31 107.1 0.0 1e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 ESS65103.1 - 7.9e-08 32.3 0.9 1.7e-07 31.2 0.6 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 ESS65103.1 - 0.0011 19.3 0.2 0.0027 18.0 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Minor_capsid_1 PF10665.4 ESS65103.1 - 0.011 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Minor capsid protein GFO_IDH_MocA PF01408.17 ESS65103.1 - 0.038 14.5 0.0 0.3 11.5 0.0 2.2 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Shikimate_DH PF01488.15 ESS65103.1 - 0.038 14.0 0.1 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 ESS65103.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase_Tyr PF07714.12 ESS65104.1 - 0.0024 17.0 0.0 0.0045 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESS65104.1 - 0.074 12.1 0.0 0.34 10.0 0.0 1.9 1 1 0 1 1 1 0 Protein kinase domain DUF972 PF06156.8 ESS65105.1 - 0.12 12.6 1.1 0.6 10.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Vac_Fusion PF02346.11 ESS65105.1 - 9.9 5.6 7.8 1.1 8.7 0.2 2.6 3 0 0 3 3 3 0 Chordopoxvirus fusion protein RRM_6 PF14259.1 ESS65108.1 - 1e-07 31.8 0.1 3.3e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS65108.1 - 2e-05 24.3 0.0 3.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS65108.1 - 3.5e-05 23.3 0.1 7.2e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Complex1_LYR PF05347.10 ESS65110.1 - 6.4e-07 29.0 0.1 1.4e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESS65110.1 - 1.3e-05 25.2 0.2 4.3e-05 23.6 0.0 1.9 2 1 0 2 2 2 1 Complex1_LYR-like Aa_trans PF01490.13 ESS65111.1 - 2.1e-50 171.3 38.9 2.7e-50 171.0 27.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Imm46 PF15585.1 ESS65112.1 - 0.29 11.2 2.0 0.39 10.7 0.2 2.0 1 1 2 3 3 3 0 Immunity protein 46 PilJ PF13675.1 ESS65112.1 - 2.7 8.3 16.7 0.085 13.1 2.8 3.1 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Filament PF00038.16 ESS65112.1 - 3.6 6.9 30.7 4.6 6.6 20.7 1.6 1 1 0 1 1 1 0 Intermediate filament protein Tnp_P_element PF12017.3 ESS65112.1 - 5.6 6.1 10.2 0.46 9.6 0.9 2.4 2 1 0 2 2 2 0 Transposase protein APG6 PF04111.7 ESS65112.1 - 9.8 5.1 30.3 0.11 11.5 11.1 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Metallophos PF00149.23 ESS65114.1 - 3.8e-26 91.7 0.0 6.2e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PMM PF03332.8 ESS65115.1 - 1e-97 326.0 1.8 1.2e-97 325.8 1.2 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 ESS65115.1 - 1.5e-08 34.5 0.0 5e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 ESS65115.1 - 0.029 13.6 0.0 3.6 6.8 0.0 2.1 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Clathrin PF00637.15 ESS65116.1 - 3.3e-13 49.4 0.8 1.7e-12 47.1 0.0 2.6 3 0 0 3 3 3 1 Region in Clathrin and VPS F-box PF00646.28 ESS65116.1 - 0.00081 18.9 0.1 0.00081 18.9 0.0 2.8 2 0 0 2 2 2 1 F-box domain FYVE_2 PF02318.11 ESS65116.1 - 0.34 10.8 4.7 0.78 9.6 3.3 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger C1_3 PF07649.7 ESS65116.1 - 0.9 9.6 11.0 0.67 10.0 5.4 2.6 2 0 0 2 2 2 0 C1-like domain FYVE PF01363.16 ESS65116.1 - 1.3 9.0 10.0 0.82 9.6 4.8 2.2 2 0 0 2 2 2 0 FYVE zinc finger TLD PF07534.11 ESS65117.1 - 2.3e-21 76.2 0.1 4.2e-10 39.7 0.0 2.2 2 0 0 2 2 2 2 TLD Sec7 PF01369.15 ESS65119.1 - 6.2e-56 189.0 0.0 1.4e-55 187.8 0.0 1.6 1 0 0 1 1 1 1 Sec7 domain DUF1981 PF09324.5 ESS65119.1 - 1.1e-21 76.1 0.0 4.2e-21 74.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) Sec7_N PF12783.2 ESS65119.1 - 4.3e-17 62.0 0.6 4.3e-17 62.0 0.4 2.5 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal LicD PF04991.8 ESS65120.1 - 7.6e-11 42.5 0.4 1.7e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 LicD family Jiv90 PF14901.1 ESS65120.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone NTP_transf_5 PF14907.1 ESS65120.1 - 0.037 13.3 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase MutS_V PF00488.16 ESS65121.1 - 5.3e-60 202.7 0.0 1.1e-59 201.7 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.15 ESS65121.1 - 6.3e-35 119.6 0.1 1.8e-34 118.1 0.0 1.9 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.13 ESS65121.1 - 3.2e-24 85.8 0.8 3.6e-17 62.8 0.1 2.6 2 0 0 2 2 2 2 MutS domain III ABC_tran PF00005.22 ESS65121.1 - 0.0014 18.8 0.0 0.0042 17.3 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 ESS65121.1 - 0.0092 15.4 0.0 0.025 14.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 ESS65121.1 - 0.038 13.4 0.0 0.21 10.9 0.0 2.1 3 0 0 3 3 3 0 AAA domain WD40 PF00400.27 ESS65122.1 - 7.2e-06 25.6 7.2 0.04 13.8 1.4 4.7 5 1 0 5 5 5 2 WD domain, G-beta repeat ALG3 PF05208.8 ESS65123.1 - 1.4e-101 340.3 18.0 1.6e-101 340.1 12.5 1.0 1 0 0 1 1 1 1 ALG3 protein Metallophos PF00149.23 ESS65124.1 - 1.1e-28 100.0 0.0 4.8e-28 97.9 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase EDR1 PF14381.1 ESS65126.1 - 3.6e-27 95.2 0.0 8.1e-27 94.1 0.0 1.6 1 1 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Pkinase PF00069.20 ESS65126.1 - 1.3e-26 93.2 0.0 2e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65126.1 - 4.9e-19 68.4 0.0 7.9e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65126.1 - 0.0087 15.0 0.0 0.018 14.0 0.0 1.4 2 0 0 2 2 2 1 Kinase-like DUF72 PF01904.13 ESS65127.1 - 7.1e-44 150.2 0.4 2.1e-41 142.1 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function DUF72 TPR_11 PF13414.1 ESS65128.1 - 5.4e-17 61.2 3.6 3.1e-11 42.7 0.1 2.3 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS65128.1 - 8.8e-11 40.8 5.8 1.2e-05 24.8 1.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65128.1 - 1.1e-10 40.6 5.7 1.2e-05 24.6 0.8 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS65128.1 - 3.9e-05 23.5 2.6 0.0039 17.0 1.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65128.1 - 7.1e-05 23.3 3.8 0.0011 19.5 2.8 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65128.1 - 0.0036 16.9 0.9 0.0036 16.9 0.7 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS65128.1 - 0.0072 16.6 3.7 0.011 16.0 1.8 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS65128.1 - 0.021 14.9 0.8 6.6 7.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS65128.1 - 0.025 15.0 2.1 0.1 13.1 1.1 2.4 2 0 0 2 2 1 0 Tetratricopeptide repeat MIT PF04212.13 ESS65128.1 - 0.033 14.0 1.5 5.4 6.9 0.4 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.1 ESS65128.1 - 0.043 13.6 3.0 0.53 10.1 1.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS65128.1 - 0.054 14.1 1.5 0.054 14.1 1.1 3.5 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS65128.1 - 0.075 12.8 0.9 8.4 6.4 0.3 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Avl9 PF09794.4 ESS65129.1 - 0.00038 19.0 0.0 0.0017 16.9 0.0 1.9 1 1 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 ESS65129.1 - 0.0055 16.3 0.0 0.04 13.6 0.0 2.1 1 1 1 2 2 2 1 Stabilization of polarity axis DENN PF02141.16 ESS65129.1 - 0.011 15.4 6.7 0.097 12.3 0.4 2.5 1 1 1 2 2 2 0 DENN (AEX-3) domain Peripla_BP_2 PF01497.13 ESS65130.1 - 0.066 12.3 0.0 0.072 12.2 0.0 1.1 1 0 0 1 1 1 0 Periplasmic binding protein Acetyltransf_1 PF00583.19 ESS65131.1 - 0.0068 16.4 0.1 0.025 14.5 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESS65131.1 - 0.011 15.9 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DnaJ PF00226.26 ESS65132.1 - 4.7e-19 67.8 0.3 8.1e-19 67.1 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.6 ESS65132.1 - 0.00026 21.2 0.0 0.0006 20.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) NETI PF14044.1 ESS65132.1 - 0.11 11.9 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 NETI protein FTCD_N PF07837.7 ESS65132.1 - 0.15 11.5 0.6 0.65 9.4 0.0 2.0 2 0 0 2 2 2 0 Formiminotransferase domain, N-terminal subdomain Arm PF00514.18 ESS65133.1 - 0.052 13.3 0.0 4.4 7.2 0.0 2.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PUL PF08324.6 ESS65133.1 - 0.061 12.1 0.2 0.12 11.1 0.1 1.4 1 0 0 1 1 1 0 PUL domain CENP-F_leu_zip PF10473.4 ESS65136.1 - 1 9.2 6.6 0.88 9.4 1.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DEAD PF00270.24 ESS65137.1 - 8.2e-32 110.0 0.0 5.3e-31 107.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65137.1 - 4.1e-26 90.6 0.0 8.7e-26 89.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HAD_2 PF13419.1 ESS65138.1 - 2.7e-14 53.7 0.0 4e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NIF PF03031.13 ESS65138.1 - 0.00017 21.2 0.1 0.004 16.8 0.0 2.2 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.21 ESS65138.1 - 0.014 15.7 0.0 0.4 11.0 0.0 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 ESS65138.1 - 0.11 12.3 0.0 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase EMP24_GP25L PF01105.19 ESS65139.1 - 3.1e-27 95.4 0.0 4.7e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD A2M_N PF01835.14 ESS65139.1 - 0.042 14.1 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 MG2 domain DUF2976 PF11190.3 ESS65139.1 - 0.068 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) G10 PF01125.12 ESS65140.1 - 1.6e-55 186.6 1.4 2.7e-55 185.9 1.0 1.4 1 0 0 1 1 1 1 G10 protein Nol1_Nop2_Fmu PF01189.12 ESS65141.1 - 8e-24 84.4 0.0 7.7e-21 74.6 0.0 2.9 2 1 0 2 2 2 1 NOL1/NOP2/sun family FtsJ PF01728.14 ESS65141.1 - 0.0031 17.5 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ribul_P_3_epim PF00834.14 ESS65141.1 - 0.031 13.3 0.0 0.058 12.4 0.0 1.4 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Y_phosphatase PF00102.22 ESS65142.1 - 5.9e-52 176.3 0.0 7e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 ESS65142.1 - 8.5e-06 25.3 0.0 2e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 ESS65142.1 - 0.00024 21.3 0.0 0.00043 20.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.1 ESS65142.1 - 0.00076 19.5 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate AvrPto PF11592.3 ESS65144.1 - 0.068 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Central core of the bacterial effector protein AvrPto Choline_transpo PF04515.7 ESS65145.1 - 5.7e-86 288.2 32.7 5.7e-86 288.2 22.6 2.5 1 1 2 3 3 3 1 Plasma-membrane choline transporter Sec1 PF00995.18 ESS65146.1 - 3.7e-118 395.6 0.0 4.2e-118 395.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family TFIIF_beta PF02270.10 ESS65146.1 - 0.17 11.6 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, beta subunit Spc97_Spc98 PF04130.8 ESS65147.1 - 2.4e-18 65.7 0.7 1.6e-16 59.7 0.0 2.5 3 0 0 3 3 3 2 Spc97 / Spc98 family MMR_HSR1 PF01926.18 ESS65148.1 - 1.2e-16 60.6 0.0 2.6e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 ESS65148.1 - 7.6e-16 57.7 0.0 1.4e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 ESS65148.1 - 2.5e-09 36.5 0.0 6.9e-09 35.1 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.11 ESS65148.1 - 0.0067 15.2 0.1 0.016 14.0 0.0 1.6 2 0 0 2 2 2 1 ArgK protein GTP_EFTU PF00009.22 ESS65148.1 - 0.0086 15.5 0.1 9.9 5.5 0.0 3.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESS65148.1 - 0.013 15.2 0.2 1.4 8.7 0.0 2.4 1 1 1 2 2 2 0 Dynamin family AAA_28 PF13521.1 ESS65148.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ESS65148.1 - 0.095 13.1 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein SRPRB PF09439.5 ESS65148.1 - 0.1 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Guanylate_kin PF00625.16 ESS65149.1 - 2.4e-39 134.6 0.0 3.4e-22 78.7 0.0 2.9 2 1 0 2 2 2 2 Guanylate kinase AAA_33 PF13671.1 ESS65149.1 - 1e-06 28.6 0.0 5.3e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS65149.1 - 0.00085 19.4 0.0 0.0024 18.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESS65149.1 - 0.00095 18.3 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS65149.1 - 0.0025 17.8 0.0 0.017 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 ESS65149.1 - 0.0029 17.0 0.0 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESS65149.1 - 0.008 16.4 0.1 0.013 15.8 0.0 1.5 1 1 0 1 1 1 1 ABC transporter NACHT PF05729.7 ESS65149.1 - 0.0092 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.17 ESS65149.1 - 0.015 15.4 0.0 0.031 14.4 0.0 1.6 2 0 0 2 2 1 0 RNA helicase AAA_17 PF13207.1 ESS65149.1 - 0.018 15.8 0.0 0.036 14.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESS65149.1 - 0.045 14.0 0.1 0.51 10.6 0.0 2.3 1 1 0 1 1 1 0 AAA domain Esterase PF00756.15 ESS65149.1 - 0.045 13.1 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative esterase MobB PF03205.9 ESS65149.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESS65149.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_10 PF12846.2 ESS65149.1 - 0.067 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain DUF1860 PF08949.5 ESS65149.1 - 0.084 12.4 0.6 0.74 9.3 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1860) TPR_11 PF13414.1 ESS65151.1 - 6.3e-39 131.4 11.4 4e-09 35.9 0.4 6.2 4 2 1 6 6 6 6 TPR repeat TPR_2 PF07719.12 ESS65151.1 - 4.1e-32 107.5 9.3 0.0014 18.3 0.0 10.0 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65151.1 - 5.5e-32 108.0 8.7 0.00021 20.7 0.0 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65151.1 - 1.6e-24 85.9 2.1 1.6e-05 25.3 0.0 7.3 5 2 2 7 7 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESS65151.1 - 1.1e-22 79.7 15.6 4.9e-05 23.1 0.1 6.8 3 2 5 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.1 ESS65151.1 - 3.4e-22 78.5 4.5 1.2e-05 25.5 0.1 6.2 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65151.1 - 8e-20 69.0 1.6 0.017 14.8 0.1 8.5 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS65151.1 - 1.2e-17 62.8 9.5 0.00074 19.9 0.0 8.8 2 2 8 10 10 10 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESS65151.1 - 2.3e-16 59.4 7.5 8e-05 22.4 0.0 6.0 4 1 4 8 8 8 4 Tetratricopeptide repeat Apc3 PF12895.2 ESS65151.1 - 4.1e-16 58.8 14.3 3.7e-05 23.7 0.1 5.5 1 1 4 6 6 6 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESS65151.1 - 9.7e-14 50.0 0.1 0.011 15.5 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESS65151.1 - 7.7e-13 47.9 6.4 0.28 11.7 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS65151.1 - 1.8e-11 43.2 15.9 0.014 15.5 0.2 9.0 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESS65151.1 - 2.1e-09 36.8 0.4 0.00016 20.8 0.0 4.0 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.1 ESS65151.1 - 0.0009 19.1 8.3 7.7 6.6 0.1 6.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESS65151.1 - 0.024 14.7 2.2 5.6 7.1 0.0 4.2 3 2 1 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESS65151.1 - 0.027 13.7 0.4 5.3 6.3 0.1 2.7 2 0 0 2 2 2 0 SHNi-TPR Paf67 PF10255.4 ESS65151.1 - 0.049 12.5 1.7 0.76 8.5 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase I-associated factor PAF67 BTAD PF03704.12 ESS65151.1 - 0.15 12.3 0.2 0.15 12.3 0.1 3.4 3 2 0 3 3 3 0 Bacterial transcriptional activator domain DUF4153 PF13687.1 ESS65152.1 - 0.085 12.3 3.9 5.1 6.5 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4153) Ribosomal_S18 PF01084.15 ESS65153.1 - 0.0014 18.4 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 Glucokinase PF02685.11 ESS65154.1 - 1.4e-18 66.7 0.0 4.4e-18 65.1 0.0 1.6 1 1 0 1 1 1 1 Glucokinase Endonuclease_5 PF04493.9 ESS65155.1 - 9.6e-51 172.0 0.0 1.3e-50 171.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V UvrC_HhH_N PF08459.6 ESS65155.1 - 0.0077 15.7 0.0 0.017 14.6 0.0 1.6 1 1 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal adh_short PF00106.20 ESS65156.1 - 3.8e-16 59.4 1.4 1.7e-15 57.2 1.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS65156.1 - 1.7e-08 34.3 0.3 2.6e-08 33.7 0.2 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 ESS65156.1 - 0.0029 16.6 0.0 0.0059 15.6 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.14 ESS65156.1 - 0.0072 15.4 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.16 ESS65156.1 - 0.014 14.8 0.0 0.05 13.0 0.0 1.9 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESS65156.1 - 0.098 12.4 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Aminotran_1_2 PF00155.16 ESS65157.1 - 6.2e-69 232.6 0.0 7e-69 232.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 ESS65157.1 - 0.0037 15.6 0.0 0.0056 15.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme BBE PF08031.7 ESS65157.1 - 0.028 14.3 0.0 11 6.0 0.0 2.5 2 0 0 2 2 2 0 Berberine and berberine like Beta_elim_lyase PF01212.16 ESS65157.1 - 0.051 12.7 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 ESS65157.1 - 0.083 11.9 0.0 0.22 10.5 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family ApoO PF09769.4 ESS65158.1 - 0.21 11.2 11.5 8.6 6.0 7.0 2.7 1 1 0 1 1 1 0 Apolipoprotein O NPV_P10 PF05531.7 ESS65158.1 - 0.76 10.0 20.5 2.6 8.3 0.0 5.0 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein ALS2CR8 PF15299.1 ESS65158.1 - 2.2 7.8 16.2 0.083 12.4 2.9 2.2 1 1 1 2 2 2 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Fib_alpha PF08702.5 ESS65158.1 - 3.6 7.7 27.6 3.2 7.8 2.4 3.4 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Mnd1 PF03962.10 ESS65158.1 - 4 7.0 32.5 0.46 10.1 2.9 3.8 1 1 3 4 4 4 0 Mnd1 family Baculo_PEP_C PF04513.7 ESS65158.1 - 5.1 6.9 20.1 6.9 6.4 7.0 3.7 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 ESS65158.1 - 9.3 6.0 25.6 1.1 9.0 1.3 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) PIH1 PF08190.7 ESS65159.1 - 1e-10 41.6 0.0 1.2e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Lipase_3 PF01764.20 ESS65160.1 - 0.0041 16.7 0.0 0.0093 15.5 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Matrilin_ccoil PF10393.4 ESS65160.1 - 0.14 11.5 0.1 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin KH_5 PF13184.1 ESS65162.1 - 0.067 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 NusA-like KH domain EF-hand_7 PF13499.1 ESS65164.1 - 1e-10 41.5 0.0 0.082 13.0 0.0 4.2 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.1 ESS65164.1 - 5.8e-06 25.7 0.0 0.73 9.8 0.0 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 ESS65164.1 - 0.0099 15.1 4.4 0.1 11.9 0.1 3.6 4 0 0 4 4 4 1 EF hand DAGK_acc PF00609.14 ESS65165.1 - 1.7e-45 155.0 0.0 2.5e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 ESS65165.1 - 5.3e-17 61.4 0.0 9.1e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain zf-CHC2 PF01807.15 ESS65165.1 - 0.045 13.3 0.1 0.097 12.2 0.1 1.5 1 0 0 1 1 1 0 CHC2 zinc finger NAD_kinase PF01513.16 ESS65165.1 - 0.053 12.3 0.0 0.13 11.0 0.0 1.6 2 0 0 2 2 2 0 ATP-NAD kinase PPTA PF01239.17 ESS65166.1 - 1.3e-19 68.5 22.1 1.5e-07 30.4 1.7 4.9 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat Fumerase PF05681.9 ESS65167.1 - 1.7e-84 283.1 0.0 2.3e-84 282.6 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.7 ESS65167.1 - 9.9e-79 263.2 0.0 1.6e-78 262.5 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus Ycf34 PF10718.4 ESS65167.1 - 0.15 12.4 0.3 0.33 11.3 0.2 1.5 1 0 0 1 1 1 0 Hypothetical chloroplast protein Ycf34 DUF342 PF03961.8 ESS65168.1 - 1.7 7.0 17.1 2.3 6.5 1.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF342) dCMP_cyt_deam_1 PF00383.17 ESS65170.1 - 0.00081 19.0 1.6 0.01 15.4 1.1 2.5 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Nol1_Nop2_Fmu PF01189.12 ESS65171.1 - 6.9e-18 65.0 0.2 1.3e-06 28.0 0.0 3.8 4 0 0 4 4 4 3 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 ESS65171.1 - 0.002 17.7 0.0 0.18 11.3 0.0 3.1 3 1 0 3 3 3 1 Methyltransferase domain PCMT PF01135.14 ESS65171.1 - 0.01 15.3 0.0 0.056 12.9 0.0 2.0 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.1 ESS65171.1 - 0.035 14.4 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 ESS65171.1 - 0.043 12.9 0.0 0.23 10.5 0.0 1.9 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 ESS65171.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase PPR_2 PF13041.1 ESS65172.1 - 1e-07 31.7 0.3 0.31 11.0 0.0 4.8 4 1 1 5 5 5 2 PPR repeat family TPR_11 PF13414.1 ESS65172.1 - 0.00056 19.4 1.3 0.023 14.3 1.1 2.7 1 1 1 2 2 2 1 TPR repeat BTAD PF03704.12 ESS65172.1 - 0.0035 17.6 0.9 0.018 15.3 0.6 2.3 1 1 0 1 1 1 1 Bacterial transcriptional activator domain PPR PF01535.15 ESS65172.1 - 0.0098 15.8 0.0 57 4.0 0.0 4.7 5 0 0 5 5 5 0 PPR repeat TPR_19 PF14559.1 ESS65172.1 - 0.14 12.5 0.7 5.5 7.4 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 ESS65173.1 - 5e-73 245.4 0.0 6.6e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65173.1 - 1.1e-39 136.1 0.0 1.5e-39 135.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65173.1 - 6.3e-05 22.0 0.0 0.00012 21.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESS65173.1 - 0.00092 18.5 0.1 0.002 17.5 0.1 1.4 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESS65173.1 - 0.0018 17.3 0.0 0.0031 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS65173.1 - 0.0045 16.7 0.0 0.017 14.8 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family YukC PF10140.4 ESS65173.1 - 0.23 9.9 0.0 0.31 9.5 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Gpi1 PF05024.10 ESS65174.1 - 1.4e-34 119.4 5.5 1.4e-34 119.4 3.8 1.6 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) SR-25 PF10500.4 ESS65176.1 - 8.7 5.7 19.8 7.7 5.9 4.5 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein HEAT_EZ PF13513.1 ESS65177.1 - 0.0011 19.3 3.4 2.7 8.5 0.0 5.1 4 1 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 ESS65177.1 - 0.049 13.9 4.8 1.2 9.4 0.0 4.4 4 1 0 4 4 4 0 HEAT repeats HEAT PF02985.17 ESS65177.1 - 0.093 12.8 2.2 12 6.3 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat Beta_helix PF13229.1 ESS65178.1 - 3.9e-84 280.1 100.5 1.1e-12 48.0 5.8 14.2 2 1 12 14 14 14 13 Right handed beta helix region NosD PF05048.8 ESS65178.1 - 2.1e-61 207.1 58.0 2.3e-09 36.7 1.4 13.5 4 1 9 14 14 14 13 Periplasmic copper-binding protein (NosD) DUF4551 PF15087.1 ESS65178.1 - 0.5 8.6 4.0 1.2 7.4 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SCHIP-1 PF10148.4 ESS65179.1 - 0.016 14.6 0.1 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 AAA_12 PF13087.1 ESS65180.1 - 1.3e-34 119.3 0.0 2.1e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESS65180.1 - 3.3e-20 72.6 0.0 4.6e-19 68.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESS65180.1 - 9.2e-09 35.1 0.0 0.00094 18.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESS65180.1 - 2.2e-05 24.1 0.0 0.00023 20.8 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain Viral_helicase1 PF01443.13 ESS65180.1 - 0.0041 16.6 1.4 1.1 8.7 0.1 3.1 2 1 1 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.11 ESS65180.1 - 0.012 14.8 0.0 0.084 12.0 0.0 2.3 3 0 0 3 3 3 0 PhoH-like protein AAA_22 PF13401.1 ESS65180.1 - 0.021 14.9 0.1 3.1 7.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 ESS65180.1 - 0.043 13.2 0.1 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ESS65180.1 - 0.069 13.9 3.4 1.9 9.3 0.9 3.3 2 1 0 2 2 2 0 AAA domain DUF3279 PF11682.3 ESS65180.1 - 0.075 12.6 0.6 0.16 11.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) DUF2075 PF09848.4 ESS65180.1 - 0.086 11.8 0.0 0.18 10.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) zf-CCHC_4 PF14392.1 ESS65180.1 - 0.17 11.5 1.4 0.37 10.4 1.0 1.6 1 0 0 1 1 1 0 Zinc knuckle UDP-g_GGTase PF06427.6 ESS65181.1 - 3.6e-62 209.3 0.0 1.2e-61 207.6 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 ESS65181.1 - 9.9e-05 21.7 0.1 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 VIT1 PF01988.14 ESS65182.1 - 2e-27 96.0 4.0 2.5e-27 95.7 2.8 1.1 1 0 0 1 1 1 1 VIT family PH PF00169.24 ESS65183.1 - 7.4e-08 32.5 0.0 0.0037 17.4 0.0 3.0 3 0 0 3 3 3 2 PH domain PH_8 PF15409.1 ESS65183.1 - 0.00046 20.2 0.1 0.0062 16.5 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.1 ESS65183.1 - 0.028 14.6 3.8 0.62 10.3 0.5 3.8 3 1 0 3 3 3 0 Pleckstrin homology domain PH_6 PF15406.1 ESS65183.1 - 0.045 13.8 0.1 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain LRR_4 PF12799.2 ESS65184.1 - 1e-12 47.3 15.2 0.036 13.6 0.7 7.1 5 2 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65184.1 - 1.2e-08 34.5 9.9 0.16 11.7 2.4 5.8 3 2 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 ESS65184.1 - 1.6e-08 33.4 23.8 4.2 7.7 0.1 10.8 7 4 3 10 10 10 5 Leucine Rich Repeat FNIP PF05725.7 ESS65184.1 - 4.9e-08 32.8 12.4 0.12 12.3 0.1 5.5 4 1 0 4 4 4 3 FNIP Repeat LRR_7 PF13504.1 ESS65184.1 - 0.00025 20.7 24.8 2.5 8.6 0.0 10.0 11 0 0 11 11 11 2 Leucine rich repeat LRR_6 PF13516.1 ESS65184.1 - 0.0014 18.4 25.1 2 8.7 0.1 8.5 9 0 0 9 9 9 3 Leucine Rich repeat WD40 PF00400.27 ESS65185.1 - 3.7e-47 156.5 16.1 3.5e-11 42.5 0.1 8.9 10 0 0 10 10 10 7 WD domain, G-beta repeat eIF2A PF08662.6 ESS65185.1 - 1e-07 31.9 0.0 0.16 11.6 0.0 4.1 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.1 ESS65185.1 - 0.00027 20.4 4.8 0.037 13.4 0.4 3.8 3 1 0 3 3 3 1 PQQ-like domain Apc4_WD40 PF12894.2 ESS65185.1 - 0.0048 16.3 0.0 0.085 12.3 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.7 ESS65185.1 - 0.033 13.8 0.1 0.32 10.7 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat CPSF_A PF03178.10 ESS65185.1 - 0.034 13.2 0.0 6.6 5.7 0.0 2.9 2 1 1 3 3 3 0 CPSF A subunit region Cytochrom_D1 PF02239.11 ESS65185.1 - 0.044 12.0 0.0 0.085 11.1 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.6 ESS65185.1 - 0.047 12.3 0.0 0.11 11.1 0.0 1.5 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) IstB_IS21 PF01695.12 ESS65185.1 - 0.14 11.5 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF3312 PF11768.3 ESS65185.1 - 0.21 9.7 0.0 1.3 7.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) Pkinase PF00069.20 ESS65186.1 - 8.3e-51 172.6 0.0 1.6e-50 171.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65186.1 - 8.5e-23 80.7 0.0 5.3e-19 68.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS65186.1 - 0.024 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESS65186.1 - 0.16 10.7 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase GDI PF00996.13 ESS65187.1 - 7e-174 578.2 0.1 8.5e-174 577.9 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Kinetocho_Slk19 PF12709.2 ESS65188.1 - 0.0058 16.6 1.2 0.0058 16.6 0.8 2.7 2 1 0 2 2 2 1 Central kinetochore-associated Snapin_Pallidin PF14712.1 ESS65188.1 - 0.096 12.9 8.6 0.16 12.3 0.8 2.5 2 0 0 2 2 2 0 Snapin/Pallidin FlaC_arch PF05377.6 ESS65188.1 - 0.19 11.6 2.3 0.23 11.3 0.1 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.6 ESS65188.1 - 0.39 10.6 8.0 0.08 12.8 1.8 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RNA_pol_Rpc34 PF05158.7 ESS65188.1 - 0.51 9.4 9.2 1.5 7.9 2.3 2.2 2 0 0 2 2 2 0 RNA polymerase Rpc34 subunit DTW PF03942.10 ESS65189.1 - 1.8e-15 56.7 0.3 5.1e-15 55.2 0.0 1.8 2 0 0 2 2 2 1 DTW domain PUA_2 PF14306.1 ESS65189.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.5 2 0 0 2 2 2 0 PUA-like domain DUF4379 PF14311.1 ESS65190.1 - 2.1e-48 161.9 19.5 7e-19 67.3 2.3 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF4379) Zn-ribbon_8 PF09723.5 ESS65190.1 - 0.00036 20.4 16.3 0.046 13.6 0.2 3.9 3 1 0 3 3 3 3 Zinc ribbon domain HypA PF01155.14 ESS65190.1 - 0.027 14.1 13.2 1.7 8.3 1.1 3.3 2 1 1 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-CSL PF05207.8 ESS65190.1 - 0.034 13.6 0.1 0.034 13.6 0.1 3.0 3 1 0 3 3 3 0 CSL zinc finger zf-MIZ PF02891.15 ESS65190.1 - 0.071 12.6 0.5 0.071 12.6 0.4 5.1 5 1 1 6 6 6 0 MIZ/SP-RING zinc finger Elf1 PF05129.8 ESS65190.1 - 4.1 7.1 11.3 4.6 7.0 0.0 4.3 3 2 1 5 5 5 0 Transcription elongation factor Elf1 like CpXC PF14353.1 ESS65190.1 - 6.9 6.6 13.4 6.5 6.7 0.0 4.3 3 1 1 4 4 4 0 CpXC protein OrfB_Zn_ribbon PF07282.6 ESS65190.1 - 9 6.0 19.5 6.5 6.4 0.4 5.2 3 3 2 5 5 5 0 Putative transposase DNA-binding domain zf-TRAF PF02176.13 ESS65191.1 - 0.00094 19.5 0.6 0.00094 19.5 0.4 3.0 2 1 1 3 3 3 1 TRAF-type zinc finger zf-C2H2 PF00096.21 ESS65191.1 - 0.91 10.0 13.3 4.1 7.9 0.1 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS65191.1 - 0.94 9.9 0.0 0.94 9.9 0.0 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger BNR_3 PF13859.1 ESS65194.1 - 6e-18 64.9 0.0 8.5e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Lysine_decarbox PF03641.9 ESS65195.1 - 2e-23 82.6 0.0 4e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase NAD_binding_1 PF00175.16 ESS65196.1 - 7.3e-24 84.4 0.0 9.4e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESS65196.1 - 0.00023 21.0 0.0 0.00066 19.6 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Vault PF01505.13 ESS65196.1 - 0.13 12.2 0.0 0.54 10.3 0.0 2.0 2 0 0 2 2 2 0 Major Vault Protein repeat MIF4G PF02854.14 ESS65197.1 - 6.3e-22 78.0 0.0 2.3e-21 76.1 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain CRM1_C PF08767.6 ESS65197.1 - 0.0091 14.9 0.0 0.019 13.8 0.0 1.4 1 0 0 1 1 1 1 CRM1 C terminal Cadherin PF00028.12 ESS65201.1 - 0.045 14.0 0.1 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 Cadherin domain Imm3 PF14425.1 ESS65201.1 - 0.098 12.6 0.2 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Immunity protein Imm3 AAA_2 PF07724.9 ESS65203.1 - 7.8e-41 139.8 1.3 2.1e-32 112.3 0.1 2.7 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESS65203.1 - 2.1e-13 50.5 0.2 3.9e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESS65203.1 - 1e-08 35.0 0.5 2.3e-05 24.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS65203.1 - 7.8e-07 29.2 0.1 0.00021 21.4 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESS65203.1 - 7.1e-06 26.1 0.4 3.2e-05 23.9 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 ESS65203.1 - 1.1e-05 26.2 0.1 4.7e-05 24.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESS65203.1 - 7.2e-05 23.0 0.1 0.00022 21.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain MCM PF00493.18 ESS65203.1 - 9.8e-05 21.3 0.0 0.0042 15.9 0.0 2.5 2 0 0 2 2 2 1 MCM2/3/5 family ClpB_D2-small PF10431.4 ESS65203.1 - 0.00022 21.0 0.9 0.00049 19.9 0.0 2.1 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein Mg_chelatase PF01078.16 ESS65203.1 - 0.00026 20.2 0.2 0.0023 17.0 0.1 2.4 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESS65203.1 - 0.00044 19.0 0.5 0.001 17.8 0.0 1.7 2 0 0 2 2 2 1 TIP49 C-terminus AAA_14 PF13173.1 ESS65203.1 - 0.0013 18.5 0.0 2.4 8.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 ESS65203.1 - 0.0015 17.6 0.1 0.0068 15.4 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 ESS65203.1 - 0.0016 18.2 0.1 0.0087 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS65203.1 - 0.0021 17.0 0.0 0.0047 15.8 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.10 ESS65203.1 - 0.0021 17.7 1.0 0.45 10.2 0.0 2.5 2 0 0 2 2 2 1 NTPase Zeta_toxin PF06414.7 ESS65203.1 - 0.0027 16.8 0.1 0.011 14.7 0.0 1.9 1 1 1 2 2 2 1 Zeta toxin DEAD PF00270.24 ESS65203.1 - 0.005 16.3 0.2 0.28 10.6 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase ATP-synt_ab PF00006.20 ESS65203.1 - 0.0087 15.5 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain UPF0079 PF02367.12 ESS65203.1 - 0.015 14.9 0.0 0.28 10.8 0.0 2.7 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 IstB_IS21 PF01695.12 ESS65203.1 - 0.016 14.6 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 ESS65203.1 - 0.018 15.2 0.0 0.77 9.9 0.0 3.0 3 0 0 3 3 3 0 RNA helicase ABC_tran PF00005.22 ESS65203.1 - 0.018 15.3 0.0 0.05 13.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.21 ESS65203.1 - 0.025 14.0 0.1 0.072 12.5 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain MMR_HSR1 PF01926.18 ESS65203.1 - 0.046 13.6 0.1 0.34 10.8 0.0 2.4 2 1 0 2 2 1 0 50S ribosome-binding GTPase AAA_28 PF13521.1 ESS65203.1 - 0.05 13.5 0.1 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain CPT PF07931.7 ESS65203.1 - 0.06 12.9 0.1 0.23 11.0 0.0 2.0 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF258 PF03193.11 ESS65203.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 ESS65203.1 - 0.13 11.8 0.1 2.9 7.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain FMO-like PF00743.14 ESS65204.1 - 3e-28 98.3 0.0 1.4e-23 82.9 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 ESS65204.1 - 6.2e-22 78.6 0.0 1.4e-21 77.5 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 ESS65204.1 - 6.3e-12 45.0 0.0 3.1e-09 36.2 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 ESS65204.1 - 3.5e-11 43.3 0.0 1.5e-08 34.7 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS65204.1 - 3.7e-06 26.8 0.0 1.7e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESS65204.1 - 3.6e-05 22.8 0.1 1.6 7.5 0.0 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESS65204.1 - 4.6e-05 23.7 0.0 0.5 10.8 0.0 3.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESS65204.1 - 0.00028 20.6 0.0 0.0012 18.5 0.0 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 ESS65204.1 - 0.011 14.6 0.8 0.049 12.4 0.8 1.9 1 1 1 2 2 2 0 FAD binding domain IlvN PF07991.7 ESS65204.1 - 0.056 12.8 0.1 0.39 10.0 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_7 PF13241.1 ESS65204.1 - 0.061 13.5 0.0 1.1 9.5 0.0 2.6 3 0 0 3 3 3 0 Putative NAD(P)-binding GIDA PF01134.17 ESS65204.1 - 0.086 11.6 0.2 0.57 8.9 0.7 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A ThiF PF00899.16 ESS65204.1 - 0.088 12.6 3.4 0.63 9.8 0.8 2.4 2 0 0 2 2 2 0 ThiF family HI0933_like PF03486.9 ESS65204.1 - 0.097 11.1 0.9 0.2 10.0 0.4 1.6 2 0 0 2 2 2 0 HI0933-like protein Mito_carr PF00153.22 ESS65206.1 - 5.5e-41 138.1 1.3 1.7e-13 50.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2043 PF09740.4 ESS65207.1 - 0.83 9.7 6.6 0.25 11.4 2.1 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2043) DEAD PF00270.24 ESS65208.1 - 3.2e-41 140.6 0.4 4.1e-41 140.2 0.3 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS65208.1 - 0.009 15.8 0.0 0.021 14.6 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UMPH-1 PF05822.7 ESS65208.1 - 0.05 12.9 0.0 0.077 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) CobA_CobO_BtuR PF02572.10 ESS65208.1 - 0.12 12.0 0.2 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP LHH PF14411.1 ESS65209.1 - 0.029 14.5 3.5 0.029 14.5 2.4 1.5 1 1 1 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH Kelch_5 PF13854.1 ESS65210.1 - 1.7e-18 66.1 6.0 0.0067 16.3 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 ESS65210.1 - 1.4e-16 60.1 0.4 0.011 15.8 0.0 7.4 6 2 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESS65210.1 - 5.5e-16 58.0 12.0 0.044 13.5 0.1 7.6 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.20 ESS65210.1 - 1.6e-12 46.7 2.1 0.0041 16.6 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESS65210.1 - 4.6e-12 45.5 7.2 0.027 14.6 0.0 6.4 4 2 2 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESS65210.1 - 5.7e-11 41.7 12.4 0.024 14.3 0.1 6.9 6 2 0 6 6 6 4 Kelch motif Metallophos PF00149.23 ESS65212.1 - 6.8e-35 120.2 0.0 9.1e-35 119.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Rab5-bind PF09311.6 ESS65214.1 - 6.3e-05 22.9 8.7 6.3e-05 22.9 6.0 2.5 3 0 0 3 3 3 1 Rabaptin-like protein RasGAP_C PF03836.10 ESS65214.1 - 0.051 13.2 4.0 0.62 9.7 0.3 2.8 3 0 0 3 3 2 0 RasGAP C-terminus Prominin PF05478.6 ESS65214.1 - 0.061 10.8 1.3 1.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Prominin DivIC PF04977.10 ESS65214.1 - 0.12 11.8 12.3 1.9 8.0 0.2 4.1 3 1 0 3 3 3 0 Septum formation initiator DUF4200 PF13863.1 ESS65214.1 - 0.49 10.3 12.5 0.77 9.7 3.8 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DUF972 PF06156.8 ESS65214.1 - 0.63 10.4 10.1 6.4 7.1 0.6 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF972) EzrA PF06160.7 ESS65214.1 - 0.67 8.0 8.9 2.2 6.3 2.8 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA ADIP PF11559.3 ESS65214.1 - 1.1 9.1 16.0 0.04 13.8 4.4 3.1 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding Med9 PF07544.8 ESS65214.1 - 1.7 8.4 8.3 1.7 8.4 0.5 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DivIVA PF05103.8 ESS65214.1 - 1.8 8.5 15.3 4.9 7.2 0.1 3.7 3 1 0 3 3 3 0 DivIVA protein IncA PF04156.9 ESS65214.1 - 2.2 7.8 19.9 1.4 8.4 2.9 3.4 3 1 1 4 4 4 0 IncA protein Microtub_assoc PF07989.6 ESS65214.1 - 3.2 7.6 6.0 0.55 10.0 0.2 2.8 3 0 0 3 3 3 0 Microtubule associated bZIP_1 PF00170.16 ESS65214.1 - 3.8 7.5 22.0 0.19 11.7 0.9 4.4 4 1 1 5 5 4 0 bZIP transcription factor APG6 PF04111.7 ESS65214.1 - 4.1 6.3 15.7 0.36 9.8 2.6 2.4 2 1 1 3 3 3 0 Autophagy protein Apg6 DUF904 PF06005.7 ESS65214.1 - 7.4 6.9 19.4 12 6.2 1.5 4.7 3 2 2 5 5 5 0 Protein of unknown function (DUF904) Pkinase PF00069.20 ESS65215.1 - 1.4e-48 165.2 0.0 2.6e-48 164.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65215.1 - 7.3e-17 61.2 0.0 2.4e-16 59.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase PIP49_C PF12260.3 ESS65215.1 - 0.00043 19.7 0.4 0.00092 18.6 0.0 1.7 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 APH PF01636.18 ESS65215.1 - 0.00048 19.9 0.0 0.0016 18.2 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS65215.1 - 0.012 15.2 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase PP2C PF00481.16 ESS65216.1 - 2.5e-66 223.7 0.1 4.1e-66 222.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESS65216.1 - 0.0043 16.4 0.0 0.011 15.1 0.0 1.7 1 0 0 1 1 1 1 Protein phosphatase 2C WD40 PF00400.27 ESS65217.1 - 2.6e-05 23.9 11.9 0.00022 20.9 0.0 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat tRNA_anti-codon PF01336.20 ESS65221.1 - 1e-07 31.7 0.0 1.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PPR_2 PF13041.1 ESS65222.1 - 0.00078 19.3 2.4 0.029 14.3 0.0 3.0 3 0 0 3 3 3 2 PPR repeat family HCV_NS5a_C PF12941.2 ESS65224.1 - 0.034 13.7 2.7 0.35 10.3 0.0 3.1 3 0 0 3 3 3 0 HCV NS5a protein C-terminal region DZR PF12773.2 ESS65224.1 - 0.07 12.9 2.2 0.19 11.5 1.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 ESS65224.1 - 0.12 12.3 1.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Nudix_N_2 PF14803.1 ESS65224.1 - 0.42 10.3 4.6 5.6 6.7 3.5 2.5 1 1 1 2 2 2 0 Nudix N-terminal DUF1682 PF07946.9 ESS65224.1 - 0.48 9.2 5.6 0.76 8.5 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Fer4_2 PF12797.2 ESS65224.1 - 0.57 10.2 3.7 1.9 8.5 0.3 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4 PF00037.22 ESS65224.1 - 0.6 9.8 5.2 1.7 8.4 0.6 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Abhydrolase_3 PF07859.8 ESS65225.1 - 8.8e-13 48.3 0.1 1.5e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 ESS65225.1 - 6.3e-12 44.9 0.1 1.3e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 ESS65225.1 - 5.4e-09 35.9 0.0 1e-08 35.0 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS65225.1 - 1.3e-07 31.7 0.1 2.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS65225.1 - 0.00033 19.9 0.3 0.41 9.8 0.2 3.2 2 1 0 2 2 2 2 Prolyl oligopeptidase family PseudoU_synth_2 PF00849.17 ESS65228.1 - 7e-20 71.5 0.0 3.8e-19 69.1 0.0 2.3 1 1 0 1 1 1 1 RNA pseudouridylate synthase Asparaginase PF00710.15 ESS65229.1 - 2.1e-67 227.2 0.0 6.7e-63 212.4 0.0 2.1 2 0 0 2 2 2 2 Asparaginase Sugarporin_N PF11471.3 ESS65230.1 - 3.5 7.3 12.2 7.7 6.2 2.9 3.2 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension PPR_2 PF13041.1 ESS65232.1 - 0.00094 19.1 0.0 0.025 14.5 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.1 ESS65232.1 - 0.075 13.3 2.7 9.7 6.7 0.0 4.4 5 0 0 5 5 5 0 Pentatricopeptide repeat domain Phospholip_B PF04916.8 ESS65233.1 - 3.2e-153 510.7 7.1 4.1e-153 510.4 4.9 1.0 1 0 0 1 1 1 1 Phospholipase B T4_Gp59_C PF08994.5 ESS65233.1 - 0.21 11.7 1.3 0.92 9.6 0.2 2.2 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase C-term DUF572 PF04502.8 ESS65234.1 - 0.019 14.1 4.4 0.027 13.7 3.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ctr PF04145.10 ESS65235.1 - 0.02 14.9 0.2 0.043 13.8 0.1 1.7 1 1 1 2 2 2 0 Ctr copper transporter family DVL PF08137.7 ESS65235.1 - 0.085 12.3 0.3 0.21 11.0 0.2 1.7 1 0 0 1 1 1 0 DVL family DUF2360 PF10152.4 ESS65235.1 - 0.2 11.9 1.7 0.31 11.3 1.2 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Ribosomal_L13 PF00572.13 ESS65236.1 - 1.3e-20 73.7 0.6 2e-20 73.1 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L13 TP53IP5 PF15331.1 ESS65236.1 - 0.084 12.7 3.1 0.094 12.6 0.0 2.1 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 CEP76-C2 PF15627.1 ESS65237.1 - 4.6e-39 133.4 0.0 7e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 CEP76 C2 domain DEAD PF00270.24 ESS65238.1 - 2.3e-41 141.1 0.0 9.2e-41 139.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65238.1 - 2.3e-24 85.0 0.9 4.8e-24 84.0 0.6 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS65238.1 - 4.2e-07 29.9 0.0 1.3e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESS65238.1 - 0.05 13.7 0.0 0.18 11.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain T4SS-DNA_transf PF02534.9 ESS65238.1 - 0.052 12.1 0.0 0.083 11.4 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_19 PF13245.1 ESS65238.1 - 0.069 12.9 0.1 0.21 11.3 0.0 1.8 1 1 0 1 1 1 0 Part of AAA domain Sua5_yciO_yrdC PF01300.13 ESS65239.1 - 4.3e-49 166.1 0.0 5.9e-49 165.7 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 ESS65239.1 - 7.3e-07 29.3 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding DUF3584 PF12128.3 ESS65240.1 - 0.00022 18.7 37.5 0.00043 17.7 26.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) D123 PF07065.9 ESS65241.1 - 8.3e-11 41.5 0.0 1.9e-10 40.3 0.0 1.5 2 0 0 2 2 2 1 D123 Myc_N PF01056.13 ESS65241.1 - 0.12 11.5 0.1 0.71 8.9 0.1 2.0 2 0 0 2 2 2 0 Myc amino-terminal region Pkinase PF00069.20 ESS65242.1 - 3.5e-42 144.3 0.0 4.4e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65242.1 - 3.9e-14 52.3 0.0 5e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS65242.1 - 0.00011 22.0 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS65242.1 - 0.00014 21.5 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.1 ESS65242.1 - 0.0061 15.5 0.0 0.02 13.8 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.6 ESS65242.1 - 0.059 12.1 0.0 0.086 11.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Cytochrom_B_N_2 PF13631.1 ESS65243.1 - 0.06 13.1 0.2 0.092 12.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB LRR_6 PF13516.1 ESS65244.1 - 4.7e-17 60.0 0.9 0.075 13.1 0.0 7.8 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.2 ESS65244.1 - 7.2e-09 35.0 1.3 0.084 12.5 0.0 5.2 4 2 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS65244.1 - 9.5e-08 31.0 0.0 3.9 7.8 0.0 6.8 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.1 ESS65244.1 - 4.3e-05 23.1 5.6 1 9.1 0.3 4.8 3 2 2 5 5 5 4 Leucine rich repeat LRR_7 PF13504.1 ESS65244.1 - 0.0041 17.0 6.9 4.7 7.8 0.0 6.1 7 0 0 7 7 7 1 Leucine rich repeat Sec3_C_2 PF15278.1 ESS65244.1 - 0.087 12.9 0.4 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Sec3 exocyst complex subunit GTP_EFTU PF00009.22 ESS65247.1 - 9.7e-56 188.1 0.0 1.7e-55 187.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 ESS65247.1 - 1.1e-19 70.0 0.0 2.4e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 ESS65247.1 - 1.3e-14 53.7 0.1 2.7e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 ESS65247.1 - 0.00011 22.1 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESS65247.1 - 0.00031 20.7 0.0 0.00076 19.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 ESS65247.1 - 0.0097 16.4 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 ESS65247.1 - 0.062 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 AIG1 family CaATP_NAI PF12515.3 ESS65247.1 - 0.064 12.7 1.9 0.11 12.0 0.5 2.0 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain FeoB_N PF02421.13 ESS65247.1 - 0.065 12.5 0.0 0.23 10.7 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B SRPRB PF09439.5 ESS65247.1 - 0.088 12.0 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Peptidase_S15 PF02129.13 ESS65248.1 - 2e-59 201.2 2.2 3e-59 200.6 1.5 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 ESS65248.1 - 5.7e-37 127.7 0.0 8.9e-37 127.0 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_6 PF12697.2 ESS65248.1 - 1.8e-12 47.6 0.1 3.8e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS65248.1 - 1.3e-09 37.9 0.0 6.9e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS65248.1 - 7.6e-09 35.0 2.4 2.9e-08 33.2 0.5 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.7 ESS65248.1 - 0.00074 18.1 0.0 0.0016 17.0 0.0 1.5 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.3 ESS65248.1 - 0.00078 19.2 0.0 0.0018 18.1 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 ESS65248.1 - 0.002 17.6 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Zip PF02535.17 ESS65249.1 - 5.5e-37 127.4 14.8 5.5e-37 127.4 10.3 2.0 2 0 0 2 2 2 1 ZIP Zinc transporter DUF21 PF01595.15 ESS65249.1 - 5.5 6.2 8.7 8.1 5.6 1.3 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF21 Zip PF02535.17 ESS65250.1 - 1.3e-35 122.9 19.3 1.5e-35 122.7 13.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Ctr PF04145.10 ESS65250.1 - 0.00041 20.4 0.1 0.002 18.1 0.0 2.2 2 1 0 2 2 2 1 Ctr copper transporter family Zip PF02535.17 ESS65251.1 - 1.7e-40 139.0 16.2 2.4e-40 138.4 11.2 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DUF3360 PF11840.3 ESS65251.1 - 0.32 9.2 16.3 0.65 8.2 3.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3360) Clc-like PF07062.7 ESS65251.1 - 1.9 7.6 6.4 2.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Clc-like MCM PF00493.18 ESS65252.1 - 7.5e-120 399.6 0.3 1.2e-119 399.0 0.2 1.3 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 ESS65252.1 - 1.3e-07 30.9 0.0 4.5e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.1 ESS65252.1 - 2.6e-06 27.9 0.0 1.6e-05 25.3 0.0 2.3 3 0 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.9 ESS65252.1 - 0.0022 17.7 0.0 0.0047 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESS65252.1 - 0.0057 16.2 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESS65252.1 - 0.028 13.8 1.1 0.04 13.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_2 PF13335.1 ESS65252.1 - 0.097 13.0 8.4 0.2 12.0 0.1 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI WW PF00397.21 ESS65253.1 - 5.7e-06 26.0 1.4 1.1e-05 25.1 1.0 1.5 1 0 0 1 1 1 1 WW domain GCD14 PF08704.5 ESS65254.1 - 1.4e-68 231.0 0.0 2.8e-41 141.6 0.0 3.0 2 1 1 3 3 3 3 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 ESS65254.1 - 3.2e-09 36.5 0.0 5.8e-09 35.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS65254.1 - 5.6e-05 23.1 0.1 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESS65254.1 - 0.00031 20.3 0.0 0.00051 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 ESS65254.1 - 0.00071 20.1 0.0 0.0014 19.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS65254.1 - 0.0038 17.6 0.0 0.19 12.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.1 ESS65254.1 - 0.014 16.2 0.0 0.035 14.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESS65254.1 - 0.025 15.0 0.0 0.2 12.1 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESS65254.1 - 0.09 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Fibrillarin PF01269.12 ESS65254.1 - 0.12 11.2 0.0 5.5 5.8 0.0 2.1 2 0 0 2 2 2 0 Fibrillarin Rft-1 PF04506.8 ESS65255.1 - 1.6e-30 106.0 3.0 1.5e-25 89.6 0.1 2.2 2 0 0 2 2 2 2 Rft protein 2-oxoacid_dh PF00198.18 ESS65256.1 - 5e-80 268.1 0.0 5.8e-80 267.8 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) ATP-synt_ab_N PF02874.18 ESS65257.1 - 1.8e-14 53.7 0.8 2.7e-14 53.1 0.5 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab PF00006.20 ESS65258.1 - 8.2e-62 208.4 0.0 1e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESS65258.1 - 2.5e-14 53.6 0.0 4.6e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain NTP_transferase PF00483.18 ESS65259.1 - 2.2e-06 27.1 0.0 3.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 ESS65259.1 - 0.00055 20.0 0.0 0.00093 19.3 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 ESS65259.1 - 0.017 14.6 0.4 0.033 13.6 0.3 1.5 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) DUF676 PF05057.9 ESS65260.1 - 1.3e-18 67.1 0.0 4.2e-18 65.4 0.0 1.8 1 1 0 1 1 1 1 Putative serine esterase (DUF676) VCBS PF13517.1 ESS65261.1 - 2.4e-11 43.8 10.8 0.0066 16.7 0.4 5.2 4 2 1 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 ESS65261.1 - 1.1e-10 40.8 10.4 0.0068 16.0 0.3 4.9 5 0 0 5 5 5 3 FG-GAP repeat TcdB_toxin_midN PF12256.3 ESS65261.1 - 0.0063 15.9 1.9 3.8 6.9 0.0 3.8 3 1 1 4 4 4 2 Insecticide toxin TcdB middle/N-terminal region ParA PF10609.4 ESS65262.1 - 4.4e-35 119.4 0.0 9.5e-35 118.3 0.0 1.6 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESS65262.1 - 5.9e-16 58.4 0.1 8.2e-16 57.9 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 ESS65262.1 - 1.7e-08 33.8 0.8 1e-07 31.3 0.6 1.9 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 ESS65262.1 - 0.0001 22.2 0.1 0.00055 19.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.13 ESS65262.1 - 0.00032 19.9 0.0 0.018 14.2 0.1 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family VirC1 PF07015.6 ESS65262.1 - 0.00099 18.2 0.2 0.0019 17.3 0.1 1.5 1 0 0 1 1 1 1 VirC1 protein ArsA_ATPase PF02374.10 ESS65262.1 - 0.002 17.2 0.4 0.002 17.2 0.3 1.8 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.1 ESS65262.1 - 0.037 13.6 0.1 6.3 6.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain YhjQ PF06564.7 ESS65262.1 - 0.083 12.2 0.1 0.15 11.4 0.1 1.5 1 1 0 1 1 1 0 YhjQ protein His_Phos_2 PF00328.17 ESS65263.1 - 0.00073 18.9 0.1 0.017 14.4 0.1 2.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Myc_N PF01056.13 ESS65264.1 - 3 6.9 4.8 5 6.1 3.3 1.3 1 0 0 1 1 1 0 Myc amino-terminal region IF4E PF01652.13 ESS65265.1 - 1.3e-29 102.9 0.0 1.6e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PAM2 PF07145.10 ESS65265.1 - 0.011 15.2 5.8 0.081 12.4 0.1 3.4 3 0 0 3 3 3 0 Ataxin-2 C-terminal region Spc42p PF11544.3 ESS65265.1 - 0.16 11.9 0.2 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 Spindle pole body component Spc42p Acyl-CoA_dh_C PF12806.2 ESS65266.1 - 3.6e-23 81.8 0.1 1.2e-22 80.1 0.0 1.8 2 0 0 2 2 2 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_1 PF00441.19 ESS65266.1 - 9e-17 61.5 0.1 7.2e-16 58.6 0.1 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 ESS65266.1 - 7.7e-15 54.1 0.0 1.6e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 ESS65266.1 - 4.5e-14 53.0 0.0 1.1e-13 51.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 ESS65266.1 - 0.0003 21.0 0.0 0.00058 20.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AcylCoA_DH_N PF12418.3 ESS65266.1 - 0.015 14.9 0.4 0.038 13.6 0.3 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase N terminal R3H PF01424.17 ESS65267.1 - 2.6e-10 39.8 0.0 6.6e-10 38.5 0.0 1.8 1 0 0 1 1 1 1 R3H domain PIF1 PF05970.9 ESS65268.1 - 4.7e-32 111.3 0.3 2.8e-28 98.9 0.0 2.8 3 0 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 ESS65268.1 - 6.1e-13 48.7 0.0 1.3e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS65268.1 - 0.00013 21.6 1.0 0.00044 19.9 0.7 1.9 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 ESS65268.1 - 0.0038 16.1 0.0 0.008 15.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Viral_helicase1 PF01443.13 ESS65268.1 - 0.0043 16.6 0.6 0.39 10.1 0.0 2.6 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase MobB PF03205.9 ESS65268.1 - 0.0051 16.5 0.1 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B UvrD-helicase PF00580.16 ESS65268.1 - 0.0079 15.5 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_11 PF13086.1 ESS65268.1 - 0.0088 15.6 0.0 0.82 9.2 0.0 2.4 1 1 1 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 ESS65268.1 - 0.012 15.7 0.0 0.038 14.1 0.0 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain IstB_IS21 PF01695.12 ESS65268.1 - 0.013 14.8 0.2 0.39 10.1 0.1 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.24 ESS65268.1 - 0.029 13.8 0.0 0.76 9.2 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase DUF853 PF05872.7 ESS65268.1 - 0.045 12.0 0.3 0.068 11.5 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AAA_22 PF13401.1 ESS65268.1 - 0.051 13.7 0.5 0.42 10.7 0.3 2.5 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESS65268.1 - 0.07 12.5 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain DUF2075 PF09848.4 ESS65268.1 - 0.08 11.9 2.8 0.075 11.9 0.4 2.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 ESS65268.1 - 0.098 12.3 0.2 0.6 9.7 0.1 2.3 2 0 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.16 ESS65268.1 - 0.1 11.7 0.4 0.24 10.5 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.11 ESS65268.1 - 0.12 11.6 0.0 0.28 10.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_32 PF13654.1 ESS65268.1 - 0.14 10.7 0.1 0.22 10.1 0.1 1.2 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESS65268.1 - 0.25 11.0 1.1 1.4 8.6 0.2 2.3 2 0 0 2 2 2 0 NTPase Herpes_Helicase PF02689.9 ESS65268.1 - 0.29 8.8 0.0 11 3.6 0.0 2.1 2 0 0 2 2 2 0 Helicase CbiA PF01656.18 ESS65268.1 - 0.44 9.9 1.6 1.3 8.3 0.7 2.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain HEAT_2 PF13646.1 ESS65271.1 - 3.5e-07 30.4 10.6 0.0021 18.3 1.0 3.8 3 2 0 3 3 3 2 HEAT repeats HEAT_2 PF13646.1 ESS65272.1 - 6.3e-11 42.4 16.5 0.06 13.6 0.2 6.9 4 1 3 7 7 7 5 HEAT repeats HEAT_EZ PF13513.1 ESS65272.1 - 1.2e-08 35.2 7.9 0.025 15.0 0.6 6.9 6 1 1 7 7 7 2 HEAT-like repeat SF3b1 PF08920.5 ESS65272.1 - 2.5e-06 27.5 0.0 4.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Splicing factor 3B subunit 1 MMS19_C PF12460.3 ESS65272.1 - 0.0014 17.4 1.2 1.7 7.2 0.0 4.2 5 0 0 5 5 5 1 RNAPII transcription regulator C-terminal HEAT PF02985.17 ESS65272.1 - 0.0014 18.5 9.8 14 6.0 0.1 7.8 7 1 0 7 7 7 1 HEAT repeat CTD PF12815.2 ESS65272.1 - 0.01 16.2 1.2 0.017 15.4 0.8 1.3 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 CLASP_N PF12348.3 ESS65272.1 - 0.015 14.6 2.3 0.32 10.2 0.1 3.4 3 1 0 4 4 4 0 CLASP N terminal Arm PF00514.18 ESS65272.1 - 0.027 14.2 1.0 2.1 8.2 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat LRR_4 PF12799.2 ESS65273.1 - 1.5e-15 56.3 8.7 9.1e-08 31.5 1.2 4.8 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) IQ PF00612.22 ESS65273.1 - 4e-14 50.8 4.4 4.4e-05 22.7 0.4 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif LRR_8 PF13855.1 ESS65273.1 - 3.6e-07 29.8 17.2 8.9e-05 22.1 0.3 4.4 3 1 1 4 4 4 3 Leucine rich repeat LRR_9 PF14580.1 ESS65273.1 - 3.8e-07 29.8 2.8 4.5e-06 26.3 0.0 3.1 3 1 0 3 3 3 1 Leucine-rich repeat LRR_1 PF00560.28 ESS65273.1 - 6.2e-05 22.4 18.4 2.3 8.5 0.1 7.6 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS65273.1 - 0.0065 16.4 18.1 12 6.5 0.0 7.6 7 1 0 7 7 7 1 Leucine rich repeat LRR_6 PF13516.1 ESS65273.1 - 0.023 14.7 17.0 17 5.8 0.0 7.2 7 1 1 8 8 8 0 Leucine Rich repeat CAP_N PF01213.14 ESS65273.1 - 0.05 12.8 0.7 0.087 12.0 0.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ADP_ribosyl_GH PF03747.9 ESS65274.1 - 2.1e-11 44.1 3.1 1.1e-07 31.9 0.1 3.2 2 1 0 3 3 3 3 ADP-ribosylglycohydrolase IQ PF00612.22 ESS65275.1 - 3.4e-16 57.2 90.1 0.00094 18.6 0.3 15.5 15 1 1 16 16 16 12 IQ calmodulin-binding motif Adaptin_N PF01602.15 ESS65276.1 - 1.2e-72 244.9 15.1 1.8e-72 244.3 10.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 ESS65276.1 - 9.6e-37 126.1 0.4 2.6e-36 124.7 0.3 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT PF02985.17 ESS65276.1 - 0.11 12.6 4.6 36 4.7 0.1 4.9 4 0 0 4 4 4 0 HEAT repeat SelR PF01641.13 ESS65278.1 - 5.4e-39 132.7 0.0 7e-39 132.3 0.0 1.1 1 0 0 1 1 1 1 SelR domain DUF2296 PF10058.4 ESS65278.1 - 0.0022 17.6 2.5 0.87 9.3 0.0 3.0 4 0 0 4 4 4 2 Predicted integral membrane metal-binding protein (DUF2296) TF_Zn_Ribbon PF08271.7 ESS65278.1 - 0.0096 15.2 0.3 0.45 9.8 0.0 2.5 2 0 0 2 2 2 1 TFIIB zinc-binding HNH_5 PF14279.1 ESS65278.1 - 0.14 12.1 0.7 0.26 11.3 0.1 1.7 2 0 0 2 2 2 0 HNH endonuclease DUF2318 PF10080.4 ESS65278.1 - 0.37 10.5 4.2 1.4 8.7 0.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) GATA PF00320.22 ESS65278.1 - 0.94 8.8 10.0 2.4 7.5 0.0 3.6 5 0 0 5 5 5 0 GATA zinc finger COX15-CtaA PF02628.10 ESS65279.1 - 2.5e-89 299.1 14.9 2.9e-89 298.9 10.4 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Metallophos PF00149.23 ESS65281.1 - 3.3e-40 137.6 0.6 4.1e-40 137.3 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase VitD-bind_III PF09164.5 ESS65281.1 - 0.079 12.5 1.5 0.13 11.8 0.4 1.8 2 0 0 2 2 2 0 Vitamin D binding protein, domain III Ribosomal_S14 PF00253.16 ESS65282.1 - 2.6e-17 61.9 3.2 2.8e-17 61.8 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e PHF5 PF03660.9 ESS65282.1 - 0.0098 15.9 0.3 0.01 15.9 0.2 1.1 1 0 0 1 1 1 1 PHF5-like protein Ribosomal_L40e PF01020.12 ESS65282.1 - 0.65 9.6 4.0 2.3 7.8 1.0 2.3 2 1 0 2 2 2 0 Ribosomal L40e family GRIM-19 PF06212.7 ESS65283.1 - 1.2e-08 34.7 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 GRIM-19 protein DPCD PF14913.1 ESS65284.1 - 7.4e-51 172.0 0.1 9.5e-51 171.6 0.1 1.0 1 0 0 1 1 1 1 DPCD protein family LacAB_rpiB PF02502.13 ESS65286.1 - 8.1e-50 168.1 0.1 9.4e-50 167.8 0.0 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase RNA_pol_L_2 PF13656.1 ESS65287.1 - 2.8e-25 87.5 0.0 4.3e-25 86.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 ESS65287.1 - 0.00028 19.9 0.0 0.00046 19.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Gemini_AL1 PF00799.15 ESS65287.1 - 0.038 13.8 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain MobA_MobL PF03389.10 ESS65287.1 - 0.08 12.3 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 MobA/MobL family zf-B_box PF00643.19 ESS65288.1 - 0.00015 21.5 2.5 0.00015 21.5 1.8 2.0 2 0 0 2 2 2 1 B-box zinc finger Myb_DNA-bind_5 PF13873.1 ESS65288.1 - 0.023 14.5 0.0 0.086 12.7 0.0 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain AAA_13 PF13166.1 ESS65288.1 - 0.027 12.9 3.4 0.046 12.1 2.4 1.3 1 0 0 1 1 1 0 AAA domain Apolipoprotein PF01442.13 ESS65288.1 - 0.073 12.5 4.6 0.049 13.1 2.0 1.5 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain COG5 PF10392.4 ESS65288.1 - 0.089 12.7 2.3 0.16 11.9 1.6 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 COG2 PF06148.6 ESS65288.1 - 0.8 9.5 6.4 6 6.7 3.9 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.9 ESS65288.1 - 1.5 8.3 5.8 2.6 7.5 4.0 1.3 1 0 0 1 1 1 0 IncA protein DUF2730 PF10805.3 ESS65289.1 - 0.03 14.0 2.4 0.092 12.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Oligomerisation PF02410.10 ESS65290.1 - 1.9e-16 59.9 0.3 3.3e-16 59.1 0.2 1.4 1 0 0 1 1 1 1 Oligomerisation domain Pkinase PF00069.20 ESS65291.1 - 2e-47 161.5 0.0 5.7e-36 124.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65291.1 - 1.2e-31 109.7 0.0 6.3e-26 91.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Beta_helix PF13229.1 ESS65291.1 - 3.5e-26 91.8 14.7 1.3e-15 57.4 2.2 3.4 2 1 2 4 4 4 2 Right handed beta helix region NosD PF05048.8 ESS65291.1 - 7.6e-21 74.3 3.9 8.7e-12 44.6 0.0 2.5 2 1 1 3 3 3 2 Periplasmic copper-binding protein (NosD) APH PF01636.18 ESS65291.1 - 9.2e-06 25.5 0.1 0.0047 16.6 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS65291.1 - 2e-05 23.7 0.0 0.00045 19.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DUF1565 PF07602.6 ESS65291.1 - 9.2e-05 21.6 3.9 0.00034 19.8 0.7 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF1565) NUDIX PF00293.23 ESS65292.1 - 0.00013 21.6 0.0 0.0005 19.7 0.0 1.9 1 1 1 2 2 2 1 NUDIX domain Patatin PF01734.17 ESS65293.1 - 2.1e-22 80.0 0.0 4.3e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3336 PF11815.3 ESS65293.1 - 6.9e-20 71.0 0.1 4.9e-19 68.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) WD40 PF00400.27 ESS65294.1 - 6.8e-14 51.1 7.9 0.0035 17.1 0.0 7.9 8 0 0 8 8 8 4 WD domain, G-beta repeat DUF3312 PF11768.3 ESS65294.1 - 0.02 13.1 0.0 0.059 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) Coatomer_WDAD PF04053.9 ESS65294.1 - 0.026 13.3 0.0 3.2 6.4 0.0 3.1 2 1 1 3 3 3 0 Coatomer WD associated region SGT1 PF07093.6 ESS65295.1 - 2.6e-05 22.8 7.9 0.0012 17.3 3.6 2.6 2 1 0 2 2 2 2 SGT1 protein RRM_1 PF00076.17 ESS65298.1 - 9.2e-19 66.8 0.0 2e-14 52.9 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS65298.1 - 1.3e-13 50.7 0.0 9.4e-09 35.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS65298.1 - 1.8e-05 24.5 0.0 0.0091 15.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kei1 PF08552.6 ESS65299.1 - 0.29 10.7 3.5 0.51 9.9 0.2 1.9 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_S49_N PF08496.5 ESS65299.1 - 6 6.6 11.8 3.6 7.3 1.7 2.0 1 1 1 2 2 2 0 Peptidase family S49 N-terminal FA_desaturase PF00487.19 ESS65300.1 - 2.6 7.3 7.8 5.7 6.3 5.4 1.6 1 1 0 1 1 1 0 Fatty acid desaturase Ependymin PF00811.13 ESS65302.1 - 0.022 14.4 0.0 0.022 14.4 0.0 1.1 1 0 0 1 1 1 0 Ependymin DnaJ PF00226.26 ESS65304.1 - 5.7e-12 45.1 0.0 1.1e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain DUF4339 PF14237.1 ESS65305.1 - 5e-15 54.7 0.4 9.9e-15 53.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) Radical_SAM PF04055.16 ESS65306.1 - 5.2e-10 39.7 0.0 8.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.15 ESS65306.1 - 0.00035 20.2 0.0 0.00092 18.9 0.1 1.7 2 0 0 2 2 2 1 TRAM domain DUF155 PF02582.9 ESS65307.1 - 1.9e-20 73.5 0.0 4.7e-20 72.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Mito_carr PF00153.22 ESS65308.1 - 6.9e-07 28.8 10.9 0.041 13.5 0.1 4.7 3 3 1 4 4 4 4 Mitochondrial carrier protein DUF204 PF02659.10 ESS65308.1 - 0.22 11.6 2.6 0.44 10.7 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF zf-C2H2_2 PF12756.2 ESS65309.1 - 1.6e-28 98.7 7.3 1.8e-20 72.9 0.1 3.4 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 ESS65309.1 - 2.9e-10 39.9 8.0 6.4e-06 26.1 0.3 4.1 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESS65309.1 - 2.1e-08 34.0 8.0 7.7e-05 22.7 0.6 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESS65309.1 - 2.1e-07 30.5 8.5 0.0026 17.5 0.3 4.1 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESS65309.1 - 7e-07 29.1 15.1 0.039 14.2 0.5 5.1 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS65309.1 - 1.3e-06 28.3 15.0 0.01 16.1 0.5 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type AKAP95 PF04988.7 ESS65309.1 - 0.012 15.4 5.9 1.2 8.8 1.4 3.1 3 1 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) DUF373 PF04123.8 ESS65310.1 - 2.4 7.0 7.8 3.6 6.5 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) E1-E2_ATPase PF00122.15 ESS65311.1 - 2.8e-12 46.1 0.0 8.6e-12 44.5 0.0 1.7 1 1 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 ESS65311.1 - 5.5e-10 39.7 0.0 2.1e-09 37.8 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESS65311.1 - 1.1e-09 39.0 0.1 0.00021 21.7 0.1 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS65311.1 - 2.9e-08 33.5 0.0 7e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESS65311.1 - 0.002 17.7 0.1 0.0049 16.4 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Intg_mem_TP0381 PF09529.5 ESS65311.1 - 0.9 8.7 8.0 0.027 13.7 1.0 1.7 2 0 0 2 2 2 0 Integral membrane protein (intg_mem_TP0381) LRR_4 PF12799.2 ESS65312.1 - 3.2e-27 93.6 10.6 5.5e-05 22.6 0.0 6.6 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65312.1 - 4.2e-17 61.6 21.9 3.3e-06 26.7 4.0 6.0 3 2 3 7 7 7 6 Leucine rich repeat LRR_6 PF13516.1 ESS65312.1 - 3.3e-07 29.6 13.7 11 6.4 0.0 8.8 8 1 1 9 9 9 1 Leucine Rich repeat LRR_1 PF00560.28 ESS65312.1 - 1.5e-06 27.4 25.8 2.7 8.3 0.4 10.0 9 1 0 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.1 ESS65312.1 - 5.9e-05 22.7 1.7 0.00043 19.8 0.0 2.9 2 1 1 3 3 3 1 Leucine-rich repeat LRR_7 PF13504.1 ESS65312.1 - 0.00064 19.5 18.3 25 5.6 0.0 9.4 10 0 0 10 10 10 0 Leucine rich repeat Candida_ALS_N PF11766.3 ESS65312.1 - 0.21 10.4 0.0 0.36 9.6 0.0 1.3 1 0 0 1 1 1 0 Cell-wall agglutinin N-terminal ligand-sugar binding TTL PF03133.10 ESS65313.1 - 1.2e-32 113.0 0.0 4.3e-32 111.2 0.0 1.9 2 1 0 2 2 2 1 Tubulin-tyrosine ligase family Helicase_C PF00271.26 ESS65314.1 - 9.6e-15 54.2 0.2 2.5e-14 52.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_4 PF13871.1 ESS65314.1 - 0.049 13.0 0.3 0.1 12.0 0.2 1.4 1 0 0 1 1 1 0 Helicase_C-like DEAD PF00270.24 ESS65315.1 - 4e-09 36.1 0.0 5.8e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS65315.1 - 0.037 13.8 0.1 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PAF-AH_p_II PF03403.8 ESS65316.1 - 1.9 6.6 5.7 3.1 6.0 4.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II NdhL PF10716.4 ESS65318.1 - 0.099 12.4 0.9 0.26 11.0 0.6 1.6 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit Mnd1 PF03962.10 ESS65319.1 - 0.00024 20.8 2.6 0.00024 20.8 1.8 3.4 3 1 1 4 4 4 1 Mnd1 family zf-C2H2 PF00096.21 ESS65319.1 - 0.022 15.0 1.2 0.022 15.0 0.9 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS65319.1 - 0.38 11.2 2.8 0.35 11.3 0.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Pyridoxal_deC PF00282.14 ESS65320.1 - 1.6e-18 66.3 0.0 4.3e-18 64.9 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 ESS65320.1 - 2.1e-07 30.0 0.0 5.2e-07 28.7 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ESS65320.1 - 0.00047 19.3 0.0 0.00078 18.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family zf-B_box PF00643.19 ESS65321.1 - 2.2e-08 33.8 30.0 8.5e-06 25.5 6.9 3.7 3 0 0 3 3 3 2 B-box zinc finger zf-C3HC4 PF00097.20 ESS65321.1 - 4.9e-07 29.2 5.4 4.9e-07 29.2 3.8 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS65321.1 - 1.1e-06 28.3 7.3 1.1e-06 28.3 5.1 3.8 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 ESS65321.1 - 0.00012 22.0 6.3 0.00012 22.0 4.4 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS65321.1 - 0.00052 19.7 6.4 0.00052 19.7 4.5 3.5 3 0 0 3 3 3 1 Ring finger domain zf-MIZ PF02891.15 ESS65321.1 - 0.0033 16.9 3.0 0.0033 16.9 2.1 2.5 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-RING_5 PF14634.1 ESS65321.1 - 0.01 15.5 6.6 0.01 15.5 4.6 3.4 3 0 0 3 3 3 0 zinc-RING finger domain DUF3138 PF11336.3 ESS65322.1 - 1.5 6.9 6.0 2.8 6.0 3.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) NTR2 PF15458.1 ESS65322.1 - 8.1 5.6 16.4 5 6.2 1.8 2.6 2 1 0 2 2 2 0 Nineteen complex-related protein 2 DUF2575 PF10837.3 ESS65323.1 - 0.028 14.5 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) UvrD-helicase PF00580.16 ESS65323.1 - 1.1 8.5 0.0 1.9 7.7 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Vps26 PF03643.10 ESS65324.1 - 1.6e-18 66.5 0.5 8.2e-18 64.1 0.4 1.8 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 ESS65324.1 - 2e-07 30.9 0.0 3.5e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Clp1 PF06807.9 ESS65326.1 - 6.5e-35 120.6 0.0 8.7e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 ESS65326.1 - 5.1e-19 68.3 0.0 8.1e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESS65326.1 - 0.0014 18.5 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESS65326.1 - 0.0038 17.2 0.0 0.0066 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESS65326.1 - 0.0074 17.0 0.0 0.02 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 ESS65326.1 - 0.01 16.3 0.0 0.019 15.4 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein DUF815 PF05673.8 ESS65326.1 - 0.017 14.0 0.0 0.026 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PduV-EutP PF10662.4 ESS65326.1 - 0.042 13.3 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 ESS65326.1 - 0.053 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.18 ESS65326.1 - 0.064 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA PF00004.24 ESS65326.1 - 0.079 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PTH2 PF01981.11 ESS65327.1 - 3.7e-16 58.8 0.0 6.1e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Prp19_bind PF06991.6 ESS65327.1 - 0.12 11.6 4.0 0.17 11.0 2.8 1.2 1 0 0 1 1 1 0 Splicing factor, Prp19-binding domain TPR_11 PF13414.1 ESS65329.1 - 5.8e-06 25.8 2.0 0.00099 18.7 0.1 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS65329.1 - 7.8e-06 25.4 1.7 0.0073 16.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS65329.1 - 0.011 15.8 0.1 0.011 15.8 0.0 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESS65329.1 - 0.013 15.8 2.1 3 8.2 0.1 2.4 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65329.1 - 0.038 13.6 2.6 0.45 10.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65329.1 - 0.15 11.8 0.2 0.81 9.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat OKR_DC_1_N PF03709.10 ESS65331.1 - 0.064 13.3 1.4 0.35 10.9 0.1 2.8 4 0 0 4 4 4 0 Orn/Lys/Arg decarboxylase, N-terminal domain RHSP PF07999.6 ESS65332.1 - 7.8e-19 67.5 0.6 2.3e-18 66.0 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein DUF3676 PF12429.3 ESS65335.1 - 4.3e-105 350.4 39.5 6.6e-105 349.8 27.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) BNR_3 PF13859.1 ESS65335.1 - 1.3e-82 277.4 0.0 1.3e-82 277.4 0.0 2.5 2 1 0 2 2 2 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS65335.1 - 3.9e-11 42.5 6.7 3.9e-11 42.5 4.6 2.2 2 0 0 2 2 2 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS65335.1 - 1.1e-09 38.7 0.8 1.1e-09 38.7 0.6 2.6 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Glycos_transf_2 PF00535.21 ESS65336.1 - 5.5e-05 22.9 0.0 0.0001 22.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS65336.1 - 0.038 13.0 0.0 3.5 6.6 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Pro_isomerase PF00160.16 ESS65337.1 - 8.2e-21 74.8 0.0 1.1e-20 74.4 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rop PF01815.11 ESS65337.1 - 0.085 12.3 0.2 1.4 8.4 0.1 2.2 2 0 0 2 2 2 0 Rop protein Mnd1 PF03962.10 ESS65339.1 - 0.077 12.6 0.3 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 Mnd1 family DCP1 PF06058.8 ESS65339.1 - 0.14 12.2 0.1 6.2 6.8 0.1 2.3 2 0 0 2 2 2 0 Dcp1-like decapping family WD40 PF00400.27 ESS65341.1 - 1.3e-09 37.5 8.3 0.00099 18.9 0.2 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF2415 PF10313.4 ESS65341.1 - 0.0083 15.7 0.2 0.04 13.5 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) LRR_6 PF13516.1 ESS65342.1 - 0.014 15.4 0.0 41 4.6 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.2 ESS65343.1 - 0.00046 19.7 5.0 2.8 7.6 0.1 4.7 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) FAD-oxidase_C PF02913.14 ESS65344.1 - 1.7e-50 171.6 0.0 2.9e-50 170.9 0.0 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 ESS65344.1 - 6.2e-35 119.6 0.0 1.1e-34 118.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain tRNA-synt_2 PF00152.15 ESS65345.1 - 2e-85 286.5 0.0 2.6e-85 286.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESS65345.1 - 3.6e-10 39.5 0.7 7.9e-10 38.4 0.5 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESS65345.1 - 2.7e-09 36.5 0.8 0.00033 19.9 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ESS65345.1 - 0.0034 16.9 0.0 2 7.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) GATase PF00117.23 ESS65346.1 - 2.4e-09 36.9 0.0 3.4e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESS65346.1 - 3.4e-08 33.2 0.1 4e-05 23.1 0.0 3.1 3 0 0 3 3 3 3 Peptidase C26 Yip1 PF04893.12 ESS65348.1 - 1e-10 41.3 9.0 1e-10 41.3 6.2 1.6 1 1 0 1 1 1 1 Yip1 domain LRR_6 PF13516.1 ESS65349.1 - 2.4e-32 107.3 10.1 0.00063 19.5 0.0 9.3 9 0 0 9 9 9 8 Leucine Rich repeat LRR_4 PF12799.2 ESS65349.1 - 4.8e-15 54.7 17.0 9.6e-05 21.9 2.1 6.2 1 1 6 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65349.1 - 4.3e-13 48.7 17.7 0.00046 19.8 0.4 6.1 2 1 3 5 5 5 5 Leucine rich repeat LRR_1 PF00560.28 ESS65349.1 - 1.3e-11 42.8 19.0 1.8 8.9 0.1 8.8 9 1 0 9 9 9 5 Leucine Rich Repeat LRR_7 PF13504.1 ESS65349.1 - 7.1e-09 34.4 15.5 3.6 8.1 0.0 9.0 9 1 0 9 9 9 2 Leucine rich repeat DUF3357 PF11837.3 ESS65349.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Rubis-subs-bind PF09273.6 ESS65350.1 - 1.3e-09 38.0 0.0 1.7e-08 34.4 0.0 2.4 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding NAD_binding_2 PF03446.10 ESS65351.1 - 7.7e-54 181.9 1.7 1.3e-53 181.1 1.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 ESS65351.1 - 9.3e-35 119.3 2.2 9.3e-35 119.3 1.5 1.6 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 ESS65351.1 - 2.4e-06 27.8 0.5 2.3e-05 24.7 0.1 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 ESS65351.1 - 7.1e-06 26.1 0.0 1.7e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 ESS65351.1 - 2.5e-05 23.5 1.2 0.00014 21.0 0.0 2.5 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESS65351.1 - 3.1e-05 23.6 1.9 7.2e-05 22.5 0.1 2.3 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 ESS65351.1 - 0.0055 16.0 0.1 0.014 14.7 0.1 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_Gly3P_dh_N PF01210.18 ESS65351.1 - 0.038 13.7 0.4 0.72 9.5 0.0 2.5 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 ESS65351.1 - 0.046 13.1 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.4 ESS65351.1 - 0.071 12.8 0.5 0.14 11.8 0.1 1.7 2 0 0 2 2 2 0 Rossmann-like domain PNK3P PF08645.6 ESS65352.1 - 1.5e-50 170.7 0.0 2.4e-50 170.0 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 ESS65352.1 - 2.3e-14 53.4 0.0 2e-13 50.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESS65352.1 - 0.00024 20.2 0.0 0.00067 18.8 0.0 1.6 1 1 1 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.18 ESS65352.1 - 0.0081 16.1 0.0 0.022 14.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESS65352.1 - 0.02 15.7 0.0 0.062 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 ESS65352.1 - 0.024 14.7 0.0 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESS65352.1 - 0.032 14.5 0.0 0.067 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS65352.1 - 0.035 14.3 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Put_Phosphatase PF06888.7 ESS65352.1 - 0.043 12.9 0.0 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 Putative Phosphatase SRPRB PF09439.5 ESS65352.1 - 0.065 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ESS65352.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.13 ESS65352.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA PF00004.24 ESS65352.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 ESS65352.1 - 0.2 11.1 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RrnaAD PF00398.15 ESS65354.1 - 9e-60 201.8 0.0 1.1e-59 201.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 ESS65354.1 - 1.5e-09 37.8 0.0 2.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS65354.1 - 2.6e-05 23.8 0.0 4.1e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS65354.1 - 2.8e-05 24.6 0.0 4.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS65354.1 - 0.00011 21.6 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 ESS65354.1 - 0.00025 20.8 0.0 0.00048 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS65354.1 - 0.00072 19.9 0.0 0.0014 19.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESS65354.1 - 0.0029 17.1 0.0 0.0046 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.7 ESS65354.1 - 0.007 15.2 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_12 PF08242.7 ESS65354.1 - 0.0077 16.6 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Pox_D5 PF03288.11 ESS65354.1 - 0.011 15.9 0.3 0.025 14.8 0.2 1.6 1 0 0 1 1 1 0 Poxvirus D5 protein-like Methyltransf_25 PF13649.1 ESS65354.1 - 0.011 16.0 0.0 0.023 15.0 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 ESS65354.1 - 0.012 14.6 0.0 0.026 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.6 ESS65354.1 - 0.087 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) zf-RanBP PF00641.13 ESS65355.1 - 3.4e-08 32.4 2.9 6.6e-08 31.5 2.0 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Mito_carr PF00153.22 ESS65356.1 - 9.5e-14 50.8 0.3 4.7e-09 35.8 0.1 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein UCH_1 PF13423.1 ESS65359.1 - 3.9e-29 102.0 0.0 1.1e-28 100.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 ESS65359.1 - 1.6e-21 77.2 0.0 5.3e-21 75.5 0.0 1.9 2 0 0 2 2 2 1 Exonuclease UCH PF00443.24 ESS65359.1 - 0.16 11.0 0.0 4.9 6.1 0.0 2.7 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF2019 PF09450.5 ESS65360.1 - 0.17 11.7 2.2 0.42 10.4 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF2019) zf-C2H2_jaz PF12171.3 ESS65361.1 - 1.5e-12 47.2 35.4 0.0002 21.4 0.0 6.3 7 0 0 7 7 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESS65361.1 - 8e-12 44.7 61.2 0.011 16.0 0.1 8.9 9 0 0 9 9 8 6 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESS65361.1 - 1.6e-10 40.9 39.1 0.003 17.6 3.4 7.3 7 0 0 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 ESS65361.1 - 5.5e-10 38.8 51.0 0.0031 17.7 0.2 8.6 8 0 0 8 8 8 5 C2H2-type zinc finger zf-met PF12874.2 ESS65361.1 - 1.6e-09 37.5 32.4 3.9e-05 23.6 0.1 7.0 7 1 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESS65361.1 - 0.00016 21.4 25.5 0.16 11.9 0.0 6.2 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESS65361.1 - 0.00038 20.5 31.6 0.64 10.1 0.2 7.0 3 2 2 5 5 5 3 C2H2 type zinc-finger (2 copies) DUF629 PF04780.7 ESS65361.1 - 0.0012 17.4 25.1 0.21 10.0 2.4 5.5 5 1 1 6 6 6 4 Protein of unknown function (DUF629) zf-met2 PF12907.2 ESS65361.1 - 0.0014 18.5 37.9 0.0015 18.4 0.1 6.8 7 1 1 8 8 8 3 Zinc-binding zf-H2C2_2 PF13465.1 ESS65361.1 - 0.024 14.9 0.7 0.024 14.9 0.5 8.8 10 1 0 10 10 10 0 Zinc-finger double domain GAGA PF09237.6 ESS65361.1 - 3.9 7.1 11.2 6.9 6.3 0.0 4.3 5 0 0 5 5 5 0 GAGA factor Peptidase_C54 PF03416.14 ESS65362.1 - 3.7e-40 137.8 0.0 6.4e-39 133.7 0.0 2.0 1 1 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.8 ESS65362.1 - 1.4e-05 24.3 0.0 0.03 13.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase family C78 Med9 PF07544.8 ESS65364.1 - 1.2 8.9 11.9 5.3 6.8 1.9 3.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Sad1_UNC PF07738.8 ESS65365.1 - 2.7e-23 82.2 0.2 5.4e-23 81.2 0.0 1.6 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal Snapin_Pallidin PF14712.1 ESS65365.1 - 0.001 19.3 1.8 0.002 18.3 1.2 1.4 1 0 0 1 1 1 1 Snapin/Pallidin PspA_IM30 PF04012.7 ESS65365.1 - 0.0045 16.3 1.0 0.0071 15.7 0.7 1.2 1 0 0 1 1 1 1 PspA/IM30 family Tropomyosin PF00261.15 ESS65365.1 - 0.035 13.1 2.7 0.07 12.2 1.9 1.4 1 0 0 1 1 1 0 Tropomyosin WEMBL PF05701.6 ESS65365.1 - 0.084 11.3 0.7 0.12 10.8 0.5 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light RabGAP-TBC PF00566.13 ESS65366.1 - 1.6e-08 34.2 0.5 2.4e-08 33.7 0.3 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ku PF02735.11 ESS65367.1 - 5.8e-22 78.0 0.0 1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.6 ESS65367.1 - 2e-19 69.6 0.0 4.7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.10 ESS65367.1 - 4.6e-08 32.7 0.0 7.7e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA_2 PF13519.1 ESS65367.1 - 0.0076 16.3 0.0 0.019 15.0 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain Arb1 PF09692.5 ESS65367.1 - 0.071 11.9 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Kinesin PF00225.18 ESS65368.1 - 2.7e-36 124.9 0.1 5e-36 124.0 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF4164 PF13747.1 ESS65368.1 - 0.032 14.3 2.4 0.032 14.3 1.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) bZIP_1 PF00170.16 ESS65368.1 - 0.035 14.0 0.5 0.035 14.0 0.4 3.6 3 2 1 4 4 4 0 bZIP transcription factor EMP70 PF02990.11 ESS65369.1 - 1.8e-135 452.3 18.4 2.6e-135 451.8 12.7 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Pkinase PF00069.20 ESS65370.1 - 1.7e-61 207.6 0.0 1.8e-60 204.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65370.1 - 6e-26 91.0 0.0 8.4e-26 90.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65370.1 - 0.00033 19.6 0.0 0.0023 16.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESS65370.1 - 0.022 13.8 0.0 0.036 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fez1 PF06818.10 ESS65371.1 - 0.027 14.4 0.7 0.027 14.4 0.5 3.1 3 0 0 3 3 3 0 Fez1 FPN1 PF06963.7 ESS65371.1 - 0.04 12.3 0.0 0.059 11.7 0.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) zf-C4H2 PF10146.4 ESS65371.1 - 0.51 10.3 4.7 0.75 9.7 3.3 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein BEX PF04538.7 ESS65371.1 - 1.9 8.7 6.5 5.8 7.1 4.4 1.8 1 1 0 1 1 1 0 Brain expressed X-linked like family SlyX PF04102.7 ESS65371.1 - 2.4 8.5 10.6 0.4 11.0 0.3 3.2 2 1 1 3 3 3 0 SlyX Cep57_MT_bd PF06657.8 ESS65371.1 - 4.7 7.2 16.0 1.4 8.9 0.0 4.8 4 1 1 6 6 6 0 Centrosome microtubule-binding domain of Cep57 PP2C PF00481.16 ESS65372.1 - 6.4e-50 169.9 0.1 9e-50 169.4 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 ESS65372.1 - 0.00031 20.4 0.0 0.04 13.6 0.0 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESS65372.1 - 0.0026 17.1 0.1 0.019 14.4 0.0 2.4 1 1 1 2 2 2 1 Protein phosphatase 2C RabGAP-TBC PF00566.13 ESS65373.1 - 3.1e-51 173.8 0.0 3.7e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Abhydrolase_5 PF12695.2 ESS65374.1 - 3.1e-17 62.6 0.0 5.1e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS65374.1 - 4e-12 46.4 0.0 6.7e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 ESS65374.1 - 3.7e-08 33.1 0.0 2.5e-07 30.4 0.0 2.0 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 ESS65374.1 - 8.8e-08 31.9 0.6 4.4e-05 23.1 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESS65374.1 - 1.7e-07 30.7 0.0 4.3e-07 29.3 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.7 ESS65374.1 - 0.00014 20.4 0.0 0.16 10.4 0.0 2.6 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) PhoPQ_related PF10142.4 ESS65374.1 - 0.00016 20.3 0.0 0.00021 19.9 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Hydrolase_4 PF12146.3 ESS65374.1 - 0.00027 20.7 0.0 0.00058 19.6 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase BAAT_C PF08840.6 ESS65374.1 - 0.011 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.8 ESS65374.1 - 0.024 14.0 0.0 0.072 12.5 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Nucleoplasmin PF03066.10 ESS65374.1 - 2.2 7.7 9.9 0.096 12.1 0.4 2.1 2 0 0 2 2 2 0 Nucleoplasmin PAP2 PF01569.16 ESS65375.1 - 7.3e-09 35.3 0.4 9.1e-09 35.0 0.2 1.2 1 0 0 1 1 1 1 PAP2 superfamily FUSC_2 PF13515.1 ESS65375.1 - 0.12 12.2 0.7 0.13 12.1 0.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein-like UPF0016 PF01169.14 ESS65375.1 - 0.22 11.6 1.0 1.5 9.0 0.7 1.9 1 1 0 1 1 1 0 Uncharacterized protein family UPF0016 WD40 PF00400.27 ESS65376.1 - 5.3e-46 152.9 16.8 7.7e-13 47.7 0.1 7.6 7 1 1 8 8 8 6 WD domain, G-beta repeat eIF2A PF08662.6 ESS65376.1 - 1.6e-08 34.4 0.0 0.0003 20.5 0.0 3.2 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 ESS65376.1 - 0.11 12.0 0.0 6.9 6.2 0.0 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Evr1_Alr PF04777.8 ESS65378.1 - 4.2e-16 58.6 0.1 9.1e-16 57.5 0.0 1.6 2 0 0 2 2 2 1 Erv1 / Alr family Thioredoxin PF00085.15 ESS65379.1 - 1.5e-09 37.4 0.4 2.3e-09 36.8 0.3 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESS65379.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Dymeclin PF09742.4 ESS65380.1 - 4e-154 514.3 0.4 4.6e-154 514.1 0.2 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.2 ESS65380.1 - 0.089 10.4 2.7 0.26 8.9 0.4 2.2 2 1 0 2 2 2 0 High-temperature-induced dauer-formation protein Ribosomal_S13 PF00416.17 ESS65381.1 - 7 7.1 7.1 61 4.1 3.4 3.0 2 1 0 2 2 2 0 Ribosomal protein S13/S18 DNA_pol_B_thumb PF14791.1 ESS65382.1 - 2.2e-12 46.5 0.0 5.2e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DUF2872 PF11071.3 ESS65383.1 - 0.022 14.6 0.4 0.047 13.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2872) zf-UBP PF02148.14 ESS65384.1 - 7.1e-13 48.4 13.1 7.1e-13 48.4 9.1 2.6 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 ESS65384.1 - 2.8e-09 36.6 6.6 2.8e-09 36.6 4.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS65384.1 - 1.1e-07 31.7 7.7 1.1e-07 31.7 5.3 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS65384.1 - 5.9e-06 25.9 6.7 5.9e-06 25.9 4.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 ESS65384.1 - 9.4e-06 25.6 4.4 9.4e-06 25.6 3.0 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESS65384.1 - 2.4e-05 23.9 7.1 2.4e-05 23.9 4.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS65384.1 - 0.0001 22.0 6.0 0.00024 20.8 2.2 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger SAA PF00277.13 ESS65384.1 - 0.11 12.8 0.4 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 Serum amyloid A protein MTHFR_C PF12225.3 ESS65384.1 - 1 8.9 9.2 1.1 8.8 4.8 2.1 1 1 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal LRRNT PF01462.13 ESS65385.1 - 0.026 14.0 0.0 0.052 13.0 0.0 1.4 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain AAA_17 PF13207.1 ESS65386.1 - 1.1e-06 29.5 0.0 2.8e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS65386.1 - 8e-06 25.9 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 ESS65386.1 - 0.00013 22.2 0.1 0.00013 22.2 0.1 2.2 3 0 0 3 3 3 1 AAA domain AAA PF00004.24 ESS65386.1 - 0.0087 16.2 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AMP-binding PF00501.23 ESS65387.1 - 3.2e-78 262.9 0.0 4.4e-78 262.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.23 ESS65388.1 - 5.1e-76 255.7 0.0 7.2e-76 255.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.23 ESS65389.1 - 1.1e-77 261.1 0.0 1.5e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CM1 PF03026.10 ESS65389.1 - 0.17 10.9 0.1 1.1 8.3 0.0 2.0 2 0 0 2 2 2 0 Influenza C virus M1 protein AMP-binding PF00501.23 ESS65390.1 - 4.9e-85 285.4 0.1 6.8e-85 284.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PGDYG PF14083.1 ESS65390.1 - 0.099 13.0 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 PGDYG protein zf-CCHC_3 PF13917.1 ESS65392.1 - 2.2e-05 24.0 13.7 0.007 16.0 0.0 3.7 3 0 0 3 3 3 2 Zinc knuckle eIF3g PF12353.3 ESS65392.1 - 0.00014 21.7 23.8 0.018 14.9 0.3 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor 3 subunit G PRP3 PF08572.5 ESS65393.1 - 5.8e-58 195.8 2.3 5.8e-58 195.8 1.6 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 ESS65393.1 - 7.2e-33 112.9 0.3 2.4e-32 111.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) PEARLI-4 PF05278.7 ESS65393.1 - 0.0076 15.6 1.9 0.038 13.3 0.3 2.2 2 0 0 2 2 2 1 Arabidopsis phospholipase-like protein (PEARLI 4) Mtc PF03820.12 ESS65394.1 - 2.6e-90 302.1 0.1 2.9e-90 302.0 0.1 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier RNA_ligase PF09414.5 ESS65396.1 - 2.2e-50 171.0 0.0 3.3e-50 170.4 0.0 1.3 1 0 0 1 1 1 1 RNA ligase RabGAP-TBC PF00566.13 ESS65397.1 - 1.5e-37 129.1 0.1 2.6e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Asp_protease PF09668.5 ESS65398.1 - 8.4e-55 183.6 0.5 1.3e-54 183.0 0.4 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 ESS65398.1 - 1e-07 32.3 0.3 2.5e-07 31.0 0.1 1.8 2 0 0 2 2 2 1 Aspartyl protease Rad60-SLD PF11976.3 ESS65398.1 - 3.2e-06 26.7 0.1 6.8e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like gag-asp_proteas PF13975.1 ESS65398.1 - 3.5e-06 26.7 0.0 7.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.18 ESS65398.1 - 0.00025 20.3 0.1 0.00047 19.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA_4 PF14555.1 ESS65398.1 - 0.00099 18.5 0.1 0.0019 17.6 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain YhzD PF14120.1 ESS65398.1 - 0.016 15.1 3.3 0.017 14.9 0.4 2.3 1 1 1 2 2 2 0 YhzD-like protein RVP_2 PF08284.6 ESS65398.1 - 0.042 13.7 0.1 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Tn7_Tnp_TnsA_C PF08721.6 ESS65399.1 - 0.024 14.6 0.7 0.9 9.5 0.0 3.0 3 0 0 3 3 3 0 TnsA endonuclease C terminal Spore_permease PF03845.8 ESS65400.1 - 1.3 7.6 8.2 2 7.0 5.7 1.2 1 0 0 1 1 1 0 Spore germination protein HSP70 PF00012.15 ESS65401.1 - 1.3e-39 135.6 0.1 1.3e-39 135.6 0.0 2.9 3 0 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.8 ESS65401.1 - 0.00043 18.9 0.0 0.001 17.7 0.0 1.5 1 0 0 1 1 1 1 MreB/Mbl protein Peptidase_M16 PF00675.15 ESS65402.1 - 2.3e-44 150.7 0.1 3.1e-43 147.0 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESS65402.1 - 8.9e-21 74.3 0.0 5e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain SH3_9 PF14604.1 ESS65403.1 - 0.062 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain C1_1 PF00130.17 ESS65403.1 - 0.47 10.2 6.9 0.26 11.0 0.4 3.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_4 PF13637.1 ESS65404.1 - 0.00012 22.4 0.0 2 9.0 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESS65404.1 - 0.00053 20.2 0.0 0.022 15.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) RRM_1 PF00076.17 ESS65405.1 - 0.00054 19.5 0.0 0.0012 18.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS65405.1 - 0.00089 19.0 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS65405.1 - 0.014 15.4 0.0 0.058 13.3 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) ThiF PF00899.16 ESS65407.1 - 8.9e-37 125.9 0.2 1.4e-36 125.3 0.1 1.3 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 ESS65407.1 - 5.4e-18 64.3 0.0 9.1e-18 63.5 0.0 1.4 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ESS65407.1 - 6.3e-09 35.0 0.3 1.3e-08 34.1 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 ESS65407.1 - 0.0015 18.6 0.0 0.0052 16.8 0.0 1.7 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 ESS65407.1 - 0.0072 16.5 0.1 0.017 15.3 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding DAO PF01266.19 ESS65407.1 - 0.0074 15.2 0.1 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESS65407.1 - 0.0078 16.5 0.4 0.019 15.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Saccharop_dh PF03435.13 ESS65407.1 - 0.028 13.3 0.1 0.072 12.0 0.0 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase ApbA PF02558.11 ESS65407.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CC2D2AN-C2 PF15625.1 ESS65409.1 - 8.3e-07 28.6 0.0 1.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.25 ESS65409.1 - 0.021 14.6 0.0 0.047 13.5 0.0 1.6 1 0 0 1 1 1 0 C2 domain DUF4336 PF14234.1 ESS65410.1 - 0.047 12.8 0.1 0.17 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4336) DUF3880 PF12996.2 ESS65410.1 - 0.06 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 DUF based on E. rectale Gene description (DUF3880) Pkinase PF00069.20 ESS65411.1 - 0.0081 15.3 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESS65412.1 - 1.7e-09 37.2 0.0 1.9e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65412.1 - 0.094 11.7 0.0 0.14 11.2 0.0 1.3 1 1 0 1 1 1 0 Protein tyrosine kinase DEAD PF00270.24 ESS65413.1 - 1.1e-38 132.3 0.2 1.1e-37 129.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65413.1 - 9.4e-28 95.8 0.2 6.7e-27 93.1 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.1 ESS65413.1 - 0.0013 17.8 0.2 0.0053 15.8 0.0 2.0 2 1 1 3 3 3 1 U3-containing 90S pre-ribosomal complex subunit DUF1460 PF07313.7 ESS65413.1 - 0.0033 16.6 0.1 1.1 8.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1460) AAA_22 PF13401.1 ESS65413.1 - 0.011 15.8 0.7 0.072 13.2 0.0 2.6 3 1 0 3 3 3 0 AAA domain DUF3128 PF11326.3 ESS65414.1 - 2.7e-15 56.2 0.0 9.4e-15 54.5 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) HYLS1_C PF15311.1 ESS65414.1 - 7e-06 26.1 1.3 2e-05 24.7 0.9 1.8 1 0 0 1 1 1 1 Hydrolethalus syndrome protein 1 C-terminus zf-C2H2_6 PF13912.1 ESS65415.1 - 0.00028 20.6 0.3 0.00051 19.8 0.2 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS65415.1 - 0.00041 20.5 1.3 0.00041 20.5 0.9 2.3 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESS65415.1 - 0.00044 20.2 0.1 0.0013 18.7 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESS65415.1 - 0.001 19.2 1.0 0.0039 17.4 0.7 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger CpXC PF14353.1 ESS65415.1 - 0.0021 17.9 0.0 0.0067 16.3 0.0 1.7 2 0 0 2 2 2 1 CpXC protein zf-H2C2_2 PF13465.1 ESS65415.1 - 0.037 14.3 0.3 0.037 14.3 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger double domain zf-ISL3 PF14690.1 ESS65415.1 - 2.5 8.1 5.2 4.7 7.3 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 BK_channel_a PF03493.13 ESS65416.1 - 4e-22 78.0 0.0 8.4e-22 77.0 0.0 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.11 ESS65416.1 - 1.1e-12 47.5 5.1 3.9e-12 45.6 3.5 2.0 1 0 0 1 1 1 1 Ion channel Isochorismatase PF00857.15 ESS65418.1 - 1.6e-28 99.7 0.1 1.8e-28 99.6 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family DUF4591 PF15261.1 ESS65421.1 - 2.5e-09 37.4 25.0 3.7e-08 33.6 2.5 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF4591) E1-E2_ATPase PF00122.15 ESS65423.1 - 2.7e-65 219.6 0.4 2.7e-65 219.6 0.3 2.0 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESS65423.1 - 3.6e-46 156.9 5.6 8e-46 155.8 3.9 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESS65423.1 - 6.1e-32 111.7 0.0 2.1e-31 109.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESS65423.1 - 3.1e-20 71.3 0.5 1.6e-19 69.0 0.0 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 ESS65423.1 - 1.8e-19 69.5 0.1 3.8e-19 68.4 0.1 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESS65423.1 - 6.4e-16 59.0 0.1 1.7e-15 57.6 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESS65423.1 - 7.8e-08 32.1 2.6 2.8e-06 27.0 0.7 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESS65423.1 - 0.028 14.6 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase VWA_2 PF13519.1 ESS65423.1 - 0.097 12.7 0.9 1 9.4 0.1 2.7 3 1 0 4 4 4 0 von Willebrand factor type A domain Ribosomal_L9_N PF01281.14 ESS65424.1 - 7.6e-05 21.8 0.0 0.00015 20.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain DUF1952 PF09189.5 ESS65424.1 - 0.023 14.4 0.2 11 5.7 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1952) Ecm29 PF13001.2 ESS65424.1 - 0.054 11.9 0.1 0.075 11.5 0.0 1.1 1 0 0 1 1 1 0 Proteasome stabiliser ABC1 PF03109.11 ESS65425.1 - 1e-29 102.9 0.0 6.1e-29 100.4 0.0 2.2 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 ESS65425.1 - 8.7e-06 25.6 0.1 1.3e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESS65425.1 - 0.095 11.8 0.0 0.26 10.3 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain UAE_UbL PF14732.1 ESS65426.1 - 5.8e-19 67.9 0.2 2.1e-17 63.0 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Tad_C PF09977.4 ESS65426.1 - 0.01 16.8 3.0 0.022 15.7 2.1 1.5 1 0 0 1 1 1 1 Putative Tad-like Flp pilus-assembly Collagen_bind PF05737.7 ESS65426.1 - 0.019 15.1 0.2 0.033 14.3 0.1 1.3 1 0 0 1 1 1 0 Collagen binding domain ThiF PF00899.16 ESS65427.1 - 1.3e-33 115.7 0.0 2.9e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.4 ESS65427.1 - 7.2e-16 57.2 0.4 1.2e-15 56.5 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 ESS65427.1 - 0.0063 16.6 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 ESS65427.1 - 0.018 15.2 0.0 0.066 13.4 0.0 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding DNase-RNase PF02577.9 ESS65427.1 - 0.067 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Bifunctional nuclease Pyr_redox PF00070.22 ESS65427.1 - 0.15 12.5 0.4 0.37 11.2 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Exo_endo_phos PF03372.18 ESS65428.1 - 1.1e-18 68.1 0.0 1.7e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESS65428.1 - 0.0048 16.4 0.0 0.013 15.1 0.0 1.7 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase CATSPERB PF15149.1 ESS65428.1 - 0.0064 14.7 0.0 0.0099 14.1 0.0 1.2 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit beta protein family Hexapep PF00132.19 ESS65429.1 - 2.1e-14 52.2 11.9 7.3e-05 22.0 3.4 3.5 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESS65429.1 - 0.036 13.6 12.6 0.35 10.4 4.0 2.7 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase DUF2205 PF10224.4 ESS65430.1 - 0.023 14.2 2.4 0.023 14.2 1.7 2.9 2 1 1 3 3 3 0 Predicted coiled-coil protein (DUF2205) ApoO PF09769.4 ESS65430.1 - 0.25 11.0 2.1 0.64 9.7 1.4 1.8 1 0 0 1 1 1 0 Apolipoprotein O Atg14 PF10186.4 ESS65430.1 - 0.25 10.2 13.2 0.53 9.1 9.1 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF848 PF05852.6 ESS65430.1 - 0.83 9.4 10.2 0.22 11.3 4.3 2.0 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) zf-C4H2 PF10146.4 ESS65430.1 - 0.96 9.4 8.6 0.27 11.2 3.5 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein Mnd1 PF03962.10 ESS65430.1 - 7.6 6.1 11.9 7 6.2 5.8 2.2 2 0 0 2 2 2 0 Mnd1 family PIG-H PF10181.4 ESS65432.1 - 8.7e-18 63.7 0.8 1.7e-17 62.7 0.3 1.7 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component ERCC4 PF02732.10 ESS65433.1 - 9.3e-18 64.3 0.0 2.8e-16 59.5 0.0 3.0 4 0 0 4 4 4 1 ERCC4 domain FYVE_2 PF02318.11 ESS65435.1 - 0.037 13.9 8.2 0.087 12.7 5.7 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-B_box PF00643.19 ESS65435.1 - 5 7.1 9.6 1.8 8.5 4.6 1.9 2 0 0 2 2 2 0 B-box zinc finger ATG16 PF08614.6 ESS65437.1 - 0.01 15.6 2.3 0.01 15.6 1.6 2.8 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) UPF0167 PF03691.9 ESS65437.1 - 0.16 11.3 0.1 8.2 5.7 0.0 2.7 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0167) Reo_sigmaC PF04582.7 ESS65437.1 - 1.5 7.9 6.8 1.3 8.1 0.5 2.7 2 1 2 4 4 4 0 Reovirus sigma C capsid protein bZIP_1 PF00170.16 ESS65437.1 - 2.2 8.3 24.7 0.17 11.8 0.6 4.7 4 1 1 5 5 5 0 bZIP transcription factor DUF641 PF04859.7 ESS65437.1 - 2.3 8.0 10.3 6.6 6.4 0.7 2.7 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DSPc PF00782.15 ESS65438.1 - 1.5e-22 79.5 0.0 2.7e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain RRM_6 PF14259.1 ESS65438.1 - 0.051 13.5 0.0 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SipA PF09052.5 ESS65438.1 - 8.6 4.6 9.5 15 3.8 6.6 1.3 1 0 0 1 1 1 0 Salmonella invasion protein A Adaptin_N PF01602.15 ESS65440.1 - 1.5e-74 251.2 0.3 1.7e-74 251.0 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESS65440.1 - 1.8e-07 31.3 0.5 0.043 14.1 0.0 3.4 2 1 0 2 2 2 2 HEAT repeats HEAT PF02985.17 ESS65440.1 - 5.9e-07 29.0 4.0 0.18 11.9 0.0 4.8 4 1 0 4 4 4 2 HEAT repeat Cnd1 PF12717.2 ESS65440.1 - 6.7e-06 26.0 2.3 0.089 12.6 0.4 3.0 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESS65440.1 - 0.0005 20.4 2.0 3.6 8.2 0.0 4.5 3 1 1 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 ESS65440.1 - 0.00054 20.2 0.3 0.1 13.0 0.0 3.2 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region Proteasom_PSMB PF10508.4 ESS65440.1 - 0.0038 15.5 0.4 0.081 11.1 0.1 2.2 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.3 ESS65440.1 - 0.022 14.7 1.2 2.1 8.2 0.0 3.4 3 1 1 4 4 4 0 V-ATPase subunit H ParcG PF10274.4 ESS65440.1 - 0.33 10.8 2.2 7 6.5 0.0 2.6 3 0 0 3 3 3 0 Parkin co-regulated protein DEAD PF00270.24 ESS65441.1 - 7e-34 116.7 0.0 1.7e-33 115.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65441.1 - 2.8e-19 68.7 0.0 8.3e-19 67.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESS65441.1 - 0.00055 20.0 0.0 0.0042 17.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain SecA_DEAD PF07517.9 ESS65441.1 - 0.0074 15.6 0.1 0.14 11.4 0.0 2.6 3 0 0 3 3 3 1 SecA DEAD-like domain SNF2_N PF00176.18 ESS65441.1 - 0.01 14.6 0.0 0.022 13.5 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain DegV PF02645.11 ESS65441.1 - 0.025 13.6 0.0 0.062 12.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 SR-25 PF10500.4 ESS65441.1 - 0.07 12.5 15.0 0.17 11.3 10.4 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ASCH PF04266.9 ESS65442.1 - 2.9e-15 56.5 0.0 8.8e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.8 ESS65442.1 - 1.7e-11 43.7 8.5 3.3e-11 42.7 5.9 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DUF3140 PF11338.3 ESS65442.1 - 0.059 13.4 0.2 0.22 11.6 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) MAD PF05557.8 ESS65443.1 - 0.047 11.7 1.2 0.061 11.4 0.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Toxin_59 PF15537.1 ESS65443.1 - 0.083 12.9 0.2 0.28 11.2 0.1 1.8 1 1 1 2 2 2 0 Putative toxin 59 TPR_2 PF07719.12 ESS65444.1 - 0.00013 21.6 0.2 4 7.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS65444.1 - 0.00016 21.5 0.7 0.014 15.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESS65444.1 - 0.0002 21.4 0.6 0.0015 18.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS65444.1 - 0.0026 18.0 0.3 0.28 11.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65444.1 - 0.0038 17.8 0.3 28 5.5 0.0 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESS65444.1 - 0.0091 15.6 0.6 4.9 6.8 0.0 3.3 3 0 0 3 3 3 1 TPR repeat TPR_6 PF13174.1 ESS65444.1 - 0.012 16.0 0.0 0.65 10.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_88 PF07470.8 ESS65444.1 - 0.02 13.9 0.0 0.041 12.9 0.0 1.5 1 1 0 1 1 1 0 Glycosyl Hydrolase Family 88 TPR_1 PF00515.23 ESS65444.1 - 0.038 13.6 1.1 4.2 7.1 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Meckelin PF09773.4 ESS65445.1 - 0 1180.0 9.7 0 1179.8 6.7 1.0 1 0 0 1 1 1 1 Meckelin (Transmembrane protein 67) DUF1469 PF07332.6 ESS65446.1 - 0.71 9.6 3.2 1.7 8.3 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1469) Aa_trans PF01490.13 ESS65447.1 - 7.6e-49 166.2 34.0 1e-48 165.8 23.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS65447.1 - 3.4e-12 45.8 10.0 3.4e-12 45.8 6.9 2.6 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family LrgA PF03788.9 ESS65448.1 - 0.12 12.0 0.1 0.68 9.6 0.0 2.1 2 1 1 3 3 3 0 LrgA family TGT PF01702.13 ESS65449.1 - 3.2e-32 111.7 0.1 1.1e-31 109.9 0.1 1.7 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF2366 PF10171.4 ESS65449.1 - 0.06 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2366) Myosin_head PF00063.16 ESS65450.1 - 2.8e-161 537.9 0.0 7.5e-161 536.5 0.0 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) IQ PF00612.22 ESS65450.1 - 1e-06 27.8 7.4 0.0037 16.7 1.3 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.1 ESS65450.1 - 0.0094 16.0 0.5 0.057 13.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF3015 PF11220.3 ESS65450.1 - 0.026 14.1 0.1 0.069 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) AAA_16 PF13191.1 ESS65450.1 - 0.057 13.4 0.0 0.057 13.4 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 ESS65450.1 - 0.44 11.3 0.0 0.44 11.3 0.0 2.8 2 1 0 2 2 2 0 AAA domain SMC_hinge PF06470.8 ESS65451.1 - 2.5e-26 91.9 0.0 1.5e-25 89.4 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.14 ESS65451.1 - 2.1e-19 69.6 29.9 2.1e-19 69.6 20.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESS65451.1 - 4.7e-17 62.9 8.6 4.7e-17 62.9 6.0 5.6 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.1 ESS65451.1 - 1.3e-06 27.8 0.0 2.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 ESS65451.1 - 3.2e-05 24.0 0.1 3.2e-05 24.0 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_13 PF13166.1 ESS65451.1 - 0.1 11.0 0.0 0.1 11.0 0.0 4.7 3 1 1 4 4 4 0 AAA domain ABC_tran PF00005.22 ESS65451.1 - 0.58 10.4 0.0 0.58 10.4 0.0 5.6 4 2 1 5 5 5 0 ABC transporter JAB PF01398.16 ESS65452.1 - 2.8e-21 75.3 0.0 4.2e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESS65452.1 - 5.8e-06 25.8 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Glyco_hydro_71 PF03659.9 ESS65452.1 - 0.029 12.8 0.0 0.04 12.4 0.0 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 71 SET PF00856.23 ESS65453.1 - 2.7e-13 50.5 0.0 7.2e-13 49.1 0.0 1.7 1 1 0 1 1 1 1 SET domain LRR_6 PF13516.1 ESS65454.1 - 3.2e-08 32.8 0.7 0.2 11.7 0.0 5.4 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.28 ESS65454.1 - 4.5e-05 22.9 0.5 17 5.9 0.0 5.5 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.2 ESS65454.1 - 0.0047 16.5 0.7 0.8 9.3 0.0 4.0 3 3 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65454.1 - 0.19 11.4 1.9 2 8.2 0.1 3.2 4 0 0 4 4 4 0 Leucine rich repeat LRR_7 PF13504.1 ESS65454.1 - 0.53 10.6 3.4 37 5.1 0.0 4.0 4 0 0 4 4 4 0 Leucine rich repeat UPF0449 PF15136.1 ESS65455.1 - 0.081 13.1 2.8 0.5 10.6 0.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF972 PF06156.8 ESS65455.1 - 4.2 7.7 12.2 9.9 6.5 1.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF972) LysM PF01476.15 ESS65457.1 - 2.3e-07 30.6 0.0 0.0089 15.9 0.0 2.6 2 0 0 2 2 2 2 LysM domain HTH_Tnp_ISL3 PF13542.1 ESS65457.1 - 0.1 11.7 0.2 2.3 7.4 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 eIF2A PF08662.6 ESS65459.1 - 7e-34 117.2 0.0 3e-32 111.9 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Reo_sigmaC PF04582.7 ESS65460.1 - 0.78 8.8 27.6 0.48 9.5 2.3 4.2 1 1 3 4 4 4 0 Reovirus sigma C capsid protein DUF869 PF05911.6 ESS65460.1 - 1.5 6.9 89.1 0.082 11.1 16.8 4.0 1 1 3 4 4 4 0 Plant protein of unknown function (DUF869) RRM_1 PF00076.17 ESS65461.1 - 2.4e-14 52.6 0.0 4.4e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.16 ESS65461.1 - 9.1e-12 45.4 0.0 3.6e-11 43.5 0.0 1.9 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_6 PF14259.1 ESS65461.1 - 3.7e-09 36.4 0.0 9.2e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS65461.1 - 3e-08 33.3 0.0 8.9e-08 31.8 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP6A_N PF04406.9 ESS65462.1 - 1e-10 41.0 3.0 4.6e-09 35.8 0.1 2.3 2 0 0 2 2 2 2 Type IIB DNA topoisomerase DUF2399 PF09664.5 ESS65462.1 - 0.0027 17.6 0.0 0.0073 16.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) DUF1788 PF08747.6 ESS65462.1 - 0.054 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) AAA_17 PF13207.1 ESS65463.1 - 2.7e-05 24.9 0.0 8.3e-05 23.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 ESS65463.1 - 0.00034 20.2 0.0 0.022 14.3 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 ESS65463.1 - 0.00079 19.7 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS65463.1 - 0.0026 17.9 0.0 0.0055 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESS65463.1 - 0.019 13.9 0.0 0.032 13.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.1 ESS65463.1 - 0.019 14.7 0.0 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Thymidylate_kin PF02223.12 ESS65463.1 - 0.045 13.1 0.0 5.3 6.3 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase CPT PF07931.7 ESS65463.1 - 0.054 13.1 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.1 ESS65463.1 - 0.059 13.3 0.1 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.16 ESS65463.1 - 0.07 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESS65463.1 - 0.074 12.9 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ESS65463.1 - 0.095 12.3 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.17 ESS65463.1 - 0.12 11.1 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.9 ESS65463.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Tetraspannin PF00335.15 ESS65464.1 - 2.7e-23 82.4 10.2 3.3e-23 82.1 7.1 1.1 1 0 0 1 1 1 1 Tetraspanin family EMP70 PF02990.11 ESS65464.1 - 0.0029 16.1 1.5 0.0046 15.4 1.0 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 ABC2_membrane PF01061.19 ESS65464.1 - 0.17 11.0 10.6 0.19 10.8 6.7 1.5 2 0 0 2 2 2 0 ABC-2 type transporter DUF443 PF04276.7 ESS65464.1 - 4.2 6.7 8.3 5.9 6.2 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF443) Orthopox_F7 PF05813.7 ESS65465.1 - 6.3 6.7 8.1 13 5.7 0.3 2.4 1 1 0 2 2 2 0 Orthopoxvirus F7 protein CPSase_L_D2 PF02786.12 ESS65466.1 - 1e-77 260.2 0.0 1.5e-77 259.6 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 ESS65466.1 - 2.4e-46 156.4 0.0 4.8e-46 155.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 ESS65466.1 - 2.8e-44 150.8 0.0 6.3e-44 149.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.14 ESS65466.1 - 4.5e-35 120.0 0.0 8.8e-35 119.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_L_chain PF00289.17 ESS65466.1 - 1e-20 73.8 0.0 2.5e-20 72.6 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 ESS65466.1 - 2.9e-11 43.4 0.0 5.7e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Peptidase_C26 PF07722.8 ESS65466.1 - 8e-08 31.9 0.2 3.8e-06 26.4 0.1 2.6 1 1 0 1 1 1 1 Peptidase C26 Dala_Dala_lig_C PF07478.8 ESS65466.1 - 0.0015 17.9 0.1 0.0032 16.8 0.1 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus DJ-1_PfpI PF01965.19 ESS65466.1 - 0.0085 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 DJ-1/PfpI family CPSase_L_D2 PF02786.12 ESS65467.1 - 6.2e-21 74.6 0.0 1.3e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.1 ESS65467.1 - 1.2e-20 74.0 0.2 4.7e-20 72.0 0.0 2.1 3 0 0 3 3 3 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESS65467.1 - 2.6e-15 56.0 0.0 5.4e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Arginosuc_synth PF00764.14 ESS65467.1 - 3e-14 52.8 0.1 1.8e-13 50.2 0.0 2.0 2 0 0 2 2 2 1 Arginosuccinate synthase CPSase_L_chain PF00289.17 ESS65467.1 - 3.4e-14 52.8 0.0 1.8e-13 50.5 0.0 2.3 3 0 0 3 3 3 1 Carbamoyl-phosphate synthase L chain, N-terminal domain MGS PF02142.17 ESS65467.1 - 3e-12 46.2 0.0 1.1e-11 44.5 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain ATP-grasp PF02222.17 ESS65467.1 - 1.5e-10 40.6 0.0 3.5e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESS65467.1 - 2.2e-05 23.9 0.0 5.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus TrkA_N PF02254.13 ESS65467.1 - 0.012 15.6 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 0 TrkA-N domain GSH-S_ATP PF02955.11 ESS65467.1 - 0.013 14.6 0.0 0.044 12.9 0.0 1.9 2 0 0 2 2 2 0 Prokaryotic glutathione synthetase, ATP-grasp domain Pyr_redox PF00070.22 ESS65467.1 - 0.029 14.7 0.1 1.1 9.7 0.0 3.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase zf-rbx1 PF12678.2 ESS65468.1 - 6.4e-20 71.0 19.7 1.2e-17 63.7 13.6 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESS65468.1 - 1.6e-11 43.8 16.6 6.7e-10 38.6 2.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 ESS65468.1 - 7.2e-10 38.5 3.7 7.2e-10 38.5 2.5 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS65468.1 - 1.7e-05 24.7 6.0 1.7e-05 24.7 4.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS65468.1 - 0.00015 21.3 2.5 0.00015 21.3 1.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS65468.1 - 0.00022 20.8 4.3 0.00022 20.8 3.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS65468.1 - 0.0005 19.7 3.1 0.0005 19.7 2.1 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.3 ESS65468.1 - 0.0076 15.7 2.2 0.02 14.3 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.3 ESS65468.1 - 0.0093 15.9 5.5 0.88 9.5 1.7 2.9 2 1 1 3 3 3 1 FANCL C-terminal domain DiS_P_DiS PF06750.8 ESS65468.1 - 0.015 15.0 5.3 0.021 14.5 0.6 2.2 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain zf-RING_6 PF14835.1 ESS65468.1 - 0.067 12.9 1.0 0.067 12.9 0.7 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 ESS65468.1 - 7.6 6.3 10.9 0.36 10.5 1.7 2.8 2 1 0 2 2 2 0 RING-type zinc-finger Baculo_RING PF05883.6 ESS65468.1 - 8 6.2 7.6 0.94 9.3 0.1 2.2 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain DUF4206 PF13901.1 ESS65468.1 - 8.9 5.8 10.1 2 7.9 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4206) zf-rbx1 PF12678.2 ESS65469.1 - 4e-16 58.8 13.6 4.8e-16 58.6 9.4 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESS65469.1 - 1.7e-10 40.6 9.9 2e-10 40.3 6.9 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 ESS65469.1 - 6.5e-05 22.6 23.1 0.00027 20.6 16.0 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS65469.1 - 0.55 10.3 20.9 8.3 6.5 14.5 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 ESS65469.1 - 0.85 9.1 8.9 1 8.9 5.7 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.1 ESS65469.1 - 1 9.1 21.1 8.9 6.1 14.7 2.3 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.20 ESS65469.1 - 2.1 8.0 20.4 8.3 6.1 14.1 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS65469.1 - 2.4 7.9 21.8 43 3.8 15.1 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PIGA PF08288.7 ESS65471.1 - 7.5e-38 128.8 0.0 1.5e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 ESS65471.1 - 3.5e-27 94.8 0.0 5.1e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 ESS65471.1 - 3.5e-12 46.7 0.5 8.9e-12 45.4 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 ESS65471.1 - 5.3e-11 42.7 0.0 1.4e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 ESS65471.1 - 1.3e-09 38.0 1.0 2.3e-08 33.9 0.4 2.8 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 ESS65471.1 - 0.012 15.8 0.0 0.032 14.5 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferases group 1 DNA_pol_B PF00136.16 ESS65472.1 - 1.3e-137 459.3 0.0 1.9e-137 458.8 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESS65472.1 - 3e-74 249.7 0.0 5.9e-74 248.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 ESS65472.1 - 2e-21 75.7 9.7 5.8e-21 74.2 6.7 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.8 ESS65472.1 - 0.041 12.5 0.5 0.71 8.4 0.0 2.8 3 0 0 3 3 3 0 DNA polymerase type B, organellar and viral RNase_H_2 PF13482.1 ESS65472.1 - 0.1 12.4 0.4 0.45 10.2 0.2 2.0 1 1 0 1 1 1 0 RNase_H superfamily SNF2_N PF00176.18 ESS65473.1 - 1.9e-78 263.3 1.1 2.5e-78 262.9 0.2 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.5 ESS65473.1 - 8.4e-27 93.2 0.9 2.4e-26 91.7 0.7 1.9 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.26 ESS65473.1 - 3.8e-16 58.7 0.0 1e-15 57.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS65473.1 - 8.3e-07 28.6 0.0 1.5e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS65473.1 - 1.4e-05 24.9 0.0 6.2e-05 22.9 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HAND PF09110.6 ESS65473.1 - 0.061 13.7 0.3 0.19 12.1 0.2 1.9 1 0 0 1 1 1 0 HAND Pkinase PF00069.20 ESS65474.1 - 4.3e-65 219.4 0.0 6.7e-65 218.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65474.1 - 1.1e-35 122.9 0.0 1.5e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.1 ESS65474.1 - 1.1e-21 76.7 0.6 3.5e-10 39.8 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS65474.1 - 4.6e-16 56.8 1.6 0.014 14.7 0.1 5.4 4 1 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 ESS65474.1 - 1.2e-13 49.6 4.0 0.084 12.8 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 ESS65474.1 - 2.3e-12 46.3 0.2 5.5e-06 25.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 ESS65474.1 - 5.5e-05 22.3 6.4 0.44 9.9 0.2 4.6 4 1 0 4 4 4 2 EF hand RIO1 PF01163.17 ESS65474.1 - 0.0015 17.9 1.7 0.0047 16.2 1.1 1.7 1 1 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESS65474.1 - 0.0035 16.3 0.1 0.024 13.6 0.0 2.1 1 1 0 2 2 2 1 Kinase-like EF-hand_9 PF14658.1 ESS65474.1 - 0.012 15.5 0.0 0.35 10.8 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain Choline_kinase PF01633.15 ESS65474.1 - 0.028 13.9 0.2 0.065 12.8 0.2 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase PMBR PF09373.5 ESS65474.1 - 0.043 13.7 0.0 0.5 10.3 0.0 2.7 2 0 0 2 2 2 0 Pseudomurein-binding repeat Kdo PF06293.9 ESS65474.1 - 0.046 12.7 0.1 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PcfK PF14058.1 ESS65475.1 - 0.19 11.8 0.0 6.2 6.9 0.0 2.6 2 0 0 2 2 2 0 PcfK-like protein Autophagy_N PF03986.8 ESS65476.1 - 1.4e-32 112.5 0.4 2.6e-32 111.6 0.1 1.6 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 ESS65476.1 - 5.4e-23 80.9 0.7 9.5e-23 80.1 0.5 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 ESS65476.1 - 3.6e-13 48.3 2.1 7.2e-13 47.3 1.5 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Peptidase_M20 PF01546.23 ESS65477.1 - 1.4e-21 76.8 0.0 2e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESS65477.1 - 5.7e-12 45.3 0.0 9.3e-12 44.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain adh_short PF00106.20 ESS65479.1 - 7.9e-23 81.2 0.0 1.3e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESS65479.1 - 5.8e-10 39.3 0.0 9.1e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESS65479.1 - 2.6e-08 33.7 0.1 6.6e-08 32.4 0.0 1.6 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.1 ESS65479.1 - 0.0019 18.2 0.1 0.016 15.2 0.0 2.1 2 0 0 2 2 2 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 ESS65479.1 - 0.0019 17.9 0.1 0.0019 17.9 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 ESS65479.1 - 0.017 14.5 0.0 0.029 13.8 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 ESS65479.1 - 0.025 13.4 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ACT_7 PF13840.1 ESS65479.1 - 0.12 11.9 0.8 0.7 9.4 0.1 2.3 2 0 0 2 2 2 0 ACT domain WD40 PF00400.27 ESS65480.1 - 1.8e-05 24.4 0.5 7.8 6.5 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat Ribul_P_3_epim PF00834.14 ESS65482.1 - 2.4e-70 235.7 0.9 2.9e-70 235.5 0.7 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family His_biosynth PF00977.16 ESS65482.1 - 0.01 15.0 0.1 0.18 11.0 0.0 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein PcrB PF01884.12 ESS65482.1 - 0.011 14.9 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 0 PcrB family OMPdecase PF00215.19 ESS65482.1 - 0.015 14.7 1.3 0.039 13.3 0.4 2.0 2 1 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Radical_SAM PF04055.16 ESS65482.1 - 0.024 14.8 0.0 1.2 9.2 0.0 2.2 1 1 0 2 2 2 0 Radical SAM superfamily PG_binding_3 PF09374.5 ESS65482.1 - 0.025 14.5 0.1 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 Predicted Peptidoglycan domain QRPTase_C PF01729.14 ESS65482.1 - 0.051 13.0 0.0 0.12 11.9 0.0 1.5 1 1 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain DUF1932 PF09130.6 ESS65482.1 - 0.076 12.7 0.3 0.23 11.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) PilN PF05137.8 ESS65483.1 - 0.047 13.5 0.3 0.099 12.4 0.2 1.5 1 0 0 1 1 1 0 Fimbrial assembly protein (PilN) HTH_8 PF02954.14 ESS65484.1 - 2.6 7.6 5.2 0.5 9.9 0.5 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family PRA1 PF03208.14 ESS65485.1 - 0.0022 17.3 0.6 0.0025 17.1 0.0 1.4 2 0 0 2 2 2 1 PRA1 family protein PPR_2 PF13041.1 ESS65487.1 - 0.1 12.6 0.0 0.58 10.1 0.0 2.3 3 0 0 3 3 3 0 PPR repeat family CCSMST1 PF15013.1 ESS65488.1 - 0.34 10.8 8.2 0.32 10.9 0.2 4.0 3 1 1 4 4 4 0 CCSMST1 family ubiquitin PF00240.18 ESS65490.1 - 3.9e-09 35.7 0.0 4.5e-06 25.9 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin family Med3 PF11593.3 ESS65490.1 - 3.8 6.6 9.9 5.9 6.0 6.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TPR_12 PF13424.1 ESS65491.1 - 7.9e-09 35.3 11.4 3.9e-05 23.4 0.2 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS65491.1 - 8.7e-08 31.4 9.1 0.14 12.0 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS65491.1 - 2.7e-07 30.6 4.6 0.00035 20.6 0.3 4.1 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ESS65491.1 - 9.6e-05 22.9 18.0 0.011 16.4 0.1 6.9 6 2 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS65491.1 - 0.00023 21.4 22.2 0.27 11.5 1.0 6.3 6 2 2 8 8 7 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS65491.1 - 0.0009 18.9 22.6 0.19 11.7 0.4 8.4 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS65491.1 - 0.0055 17.2 21.5 2.7 8.8 0.2 8.0 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS65491.1 - 0.0098 15.5 23.4 0.15 11.7 0.5 5.9 6 1 1 7 7 7 3 TPR repeat TPR_4 PF07721.9 ESS65491.1 - 0.032 14.6 10.9 17 6.1 0.2 6.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65491.1 - 0.04 13.7 11.4 2.4 8.1 0.3 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat GP120 PF00516.13 ESS65491.1 - 0.31 9.2 0.9 1 7.4 0.0 1.9 2 0 0 2 2 2 0 Envelope glycoprotein GP120 DUF3856 PF12968.2 ESS65491.1 - 1.3 8.8 11.2 3.5 7.4 0.0 4.0 4 0 0 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_1 PF00515.23 ESS65491.1 - 4.7 6.9 21.7 2.6 7.7 0.0 6.6 9 0 0 9 9 8 0 Tetratricopeptide repeat Cnd3 PF12719.2 ESS65493.1 - 0.0095 14.9 0.1 0.017 14.0 0.1 1.3 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain DUF1129 PF06570.6 ESS65493.1 - 0.85 8.8 4.7 1.8 7.8 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) F-box-like PF12937.2 ESS65494.1 - 2.5e-05 23.8 0.0 4.9e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESS65494.1 - 5.5e-05 22.6 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 F-box domain Aa_trans PF01490.13 ESS65495.1 - 1.8e-53 181.5 17.6 2.1e-53 181.2 12.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS65495.1 - 7.8e-08 31.5 13.7 2.1e-07 30.0 9.5 1.8 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family RhodobacterPufX PF11511.3 ESS65495.1 - 5.6 6.4 7.8 1.8 8.0 0.0 3.3 3 0 0 3 3 3 0 Intrinsic membrane protein PufX Pkinase PF00069.20 ESS65496.1 - 1.3e-51 175.2 0.0 9.8e-51 172.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65496.1 - 2.7e-31 108.5 0.0 9.9e-31 106.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 ESS65496.1 - 1.1e-15 57.4 1.4 1.1e-07 31.8 0.1 2.9 3 0 0 3 3 3 2 FHA domain Kinase-like PF14531.1 ESS65496.1 - 3.2e-09 36.1 0.0 6.6e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESS65496.1 - 0.0011 18.3 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESS65496.1 - 0.057 13.1 0.0 0.13 11.9 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESS65498.1 - 5.6e-65 219.0 0.0 8.2e-65 218.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65498.1 - 1.7e-30 106.0 0.1 3.2e-30 105.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESS65498.1 - 1.7e-06 27.2 0.4 2.9e-06 26.4 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESS65498.1 - 7.5e-06 25.1 0.0 2.1e-05 23.6 0.0 1.7 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.17 ESS65498.1 - 0.01 15.1 0.2 0.024 13.9 0.1 1.6 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 ESS65498.1 - 0.077 12.7 0.6 0.45 10.1 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family AAA_25 PF13481.1 ESS65500.1 - 5.9e-07 29.0 0.1 3.7e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain RecA PF00154.16 ESS65500.1 - 1.6e-06 27.4 0.0 2.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.6 ESS65500.1 - 0.00047 19.1 0.0 0.0018 17.1 0.0 1.9 2 0 0 2 2 2 1 Rad51 AAA_33 PF13671.1 ESS65500.1 - 0.0095 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 ESS65500.1 - 0.02 14.4 0.1 0.069 12.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain ArgK PF03308.11 ESS65500.1 - 0.027 13.2 0.1 0.045 12.5 0.1 1.3 1 0 0 1 1 1 0 ArgK protein AAA_16 PF13191.1 ESS65500.1 - 0.047 13.6 0.0 0.64 9.9 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 ESS65500.1 - 0.076 13.1 0.0 0.72 10.0 0.0 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS65500.1 - 0.1 12.8 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter KaiC PF06745.8 ESS65500.1 - 0.15 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 KaiC SNARE PF05739.14 ESS65503.1 - 2.2e-18 65.6 3.0 2.2e-18 65.6 2.1 2.7 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESS65503.1 - 0.0016 18.5 2.4 0.0016 18.5 1.7 2.5 2 1 0 2 2 2 1 Syntaxin Dak1_2 PF13684.1 ESS65503.1 - 0.0021 17.0 0.4 0.0021 17.0 0.3 1.8 2 0 0 2 2 2 1 Dihydroxyacetone kinase family DUF2120 PF09893.4 ESS65503.1 - 0.31 10.9 5.3 0.43 10.5 1.4 2.2 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) DUF1664 PF07889.7 ESS65503.1 - 1.7 8.4 12.2 4.7 7.0 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 ESS65503.1 - 5.4 7.4 12.9 3 8.2 1.4 3.2 1 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF3652 PF12372.3 ESS65504.1 - 0.026 14.1 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Huntingtin protein region PI3_PI4_kinase PF00454.22 ESS65505.1 - 0.0083 15.6 0.0 0.014 14.8 0.0 1.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Nexin_C PF08628.7 ESS65505.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Sorting nexin C terminal IL32 PF15225.1 ESS65506.1 - 0.042 13.7 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 Interleukin 32 MFS_1 PF07690.11 ESS65507.1 - 1.1e-17 63.7 35.6 5.1e-11 41.8 2.9 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.11 ESS65507.1 - 5.3e-13 48.5 20.2 7.3e-13 48.0 14.0 1.1 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1_like PF12832.2 ESS65507.1 - 0.00011 21.9 0.9 0.00011 21.9 0.7 2.4 2 0 0 2 2 2 1 MFS_1 like family LacY_symp PF01306.14 ESS65507.1 - 0.0066 15.0 22.8 0.018 13.6 15.8 1.7 1 1 0 1 1 1 1 LacY proton/sugar symporter Pox_A_type_inc PF04508.7 ESS65508.1 - 0.093 12.5 3.7 0.23 11.3 2.6 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat ABC1 PF03109.11 ESS65509.1 - 2.9e-27 95.0 0.0 6.3e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 ESS65509.1 - 0.015 15.0 0.0 0.03 14.0 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Rotamase PF00639.16 ESS65510.1 - 0.067 13.9 0.0 0.11 13.2 0.0 1.4 1 0 0 1 1 1 0 PPIC-type PPIASE domain Sec66 PF09802.4 ESS65510.1 - 0.083 12.2 0.1 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 GAS2 PF02187.12 ESS65513.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain Pro_isomerase PF00160.16 ESS65517.1 - 5.8e-46 156.5 0.1 6.7e-46 156.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_12 PF13424.1 ESS65518.1 - 3.2e-19 68.6 8.4 3.3e-09 36.5 0.7 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65518.1 - 8.5e-13 47.3 5.5 0.067 12.8 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESS65518.1 - 9.5e-12 43.8 8.9 0.34 10.9 0.0 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.1 ESS65518.1 - 4.7e-11 42.1 8.5 3.8e-05 23.2 0.3 3.9 1 1 2 4 4 4 4 TPR repeat TPR_8 PF13181.1 ESS65518.1 - 2.5e-09 36.2 0.7 0.35 10.7 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS65518.1 - 3.3e-07 29.5 6.8 1.8 8.5 0.1 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65518.1 - 0.00084 19.9 3.1 2.4 8.9 0.1 4.1 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS65518.1 - 0.0018 18.0 0.0 0.0018 18.0 0.0 3.6 5 1 0 5 5 5 1 Tetratricopeptide repeat DUF309 PF03745.9 ESS65518.1 - 0.015 14.7 0.1 0.26 10.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF309) TPR_10 PF13374.1 ESS65518.1 - 0.017 15.0 5.6 15 5.6 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat PMEI PF04043.10 ESS65518.1 - 0.04 13.8 1.5 0.15 11.9 0.5 2.4 2 1 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor TPR_21 PF09976.4 ESS65518.1 - 0.05 13.5 0.0 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS65518.1 - 0.072 13.7 4.0 20 6.1 0.1 4.5 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS65518.1 - 0.51 10.9 4.7 38 5.0 0.0 4.8 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS65518.1 - 1 9.9 4.1 2 9.0 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat GDPD PF03009.12 ESS65519.1 - 3.5e-26 92.2 0.0 7.6e-23 81.3 0.0 3.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EpsG PF14897.1 ESS65520.1 - 5.9 5.7 13.6 6.8 5.5 9.4 1.1 1 0 0 1 1 1 0 EpsG family zf-C3HC4_3 PF13920.1 ESS65521.1 - 9.9e-14 50.7 6.0 1.6e-13 50.0 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS65521.1 - 3.4e-08 33.3 8.2 6.2e-08 32.5 5.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS65521.1 - 5.5e-06 26.1 8.1 1.1e-05 25.0 5.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESS65521.1 - 0.00031 20.4 5.1 0.00056 19.5 3.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESS65521.1 - 0.042 13.7 7.8 0.095 12.5 5.4 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RecR PF02132.10 ESS65521.1 - 0.4 10.1 3.7 13 5.2 0.0 2.7 2 1 0 2 2 2 0 RecR protein Prok-RING_4 PF14447.1 ESS65521.1 - 1.7 8.2 8.2 19 4.8 5.7 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Ank_4 PF13637.1 ESS65522.1 - 2.8e-07 30.8 0.0 0.012 16.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS65522.1 - 9.5e-07 28.4 0.6 0.0097 16.0 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 ESS65522.1 - 6.2e-06 26.4 1.6 0.00035 20.8 0.7 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESS65522.1 - 6.5e-06 25.6 0.5 0.14 12.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 ESS65522.1 - 0.00058 20.0 0.4 0.051 13.8 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) CDC45 PF02724.9 ESS65523.1 - 0.0032 15.5 1.0 0.0032 15.5 0.7 1.6 2 0 0 2 2 2 1 CDC45-like protein PBP1_TM PF14812.1 ESS65523.1 - 3.6 7.9 16.3 9.3 6.6 4.6 3.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.7 ESS65523.1 - 7.2 4.3 11.4 0.24 9.2 3.0 1.9 2 0 0 2 2 2 0 Nop14-like family Vps51 PF08700.6 ESS65525.1 - 1.9e-15 56.4 2.8 3.5e-15 55.6 0.9 1.9 2 0 0 2 2 2 1 Vps51/Vps67 GlcNAc PF11397.3 ESS65526.1 - 2.1e-18 66.5 0.0 5.4e-09 35.6 0.0 3.2 3 0 0 3 3 3 2 Glycosyltransferase (GlcNAc) GlcNAc PF11397.3 ESS65527.1 - 1.7e-108 362.7 0.0 2.7e-108 362.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) Glyco_tranf_2_3 PF13641.1 ESS65527.1 - 0.002 17.9 0.1 0.0093 15.7 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Pkinase PF00069.20 ESS65529.1 - 3.4e-55 186.9 0.0 4.3e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65529.1 - 1.6e-18 66.7 0.0 2.5e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESS65529.1 - 0.00013 21.0 0.0 0.00022 20.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS65529.1 - 0.00029 20.6 0.8 0.25 11.0 0.4 3.1 2 1 0 3 3 3 1 Phosphotransferase enzyme family DUF3816 PF12822.2 ESS65530.1 - 0.076 12.8 0.4 0.09 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) 7tm_6 PF02949.15 ESS65530.1 - 0.18 10.6 7.0 0.19 10.5 4.9 1.0 1 0 0 1 1 1 0 7tm Odorant receptor PCI PF01399.22 ESS65532.1 - 3.1e-14 53.1 1.0 3.1e-14 53.1 0.7 1.7 2 0 0 2 2 2 1 PCI domain DUF3534 PF12053.3 ESS65532.1 - 0.077 12.8 0.2 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3534) DDRGK PF09756.4 ESS65532.1 - 0.48 9.8 15.9 0.061 12.7 0.9 2.5 2 1 0 2 2 2 0 DDRGK domain DUF4398 PF14346.1 ESS65533.1 - 0.53 10.3 8.0 1.3 9.1 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) TPR_16 PF13432.1 ESS65533.1 - 2.3 8.9 17.8 0.13 12.9 1.0 4.2 2 2 2 4 4 4 0 Tetratricopeptide repeat FtsJ PF01728.14 ESS65534.1 - 2.7e-61 206.7 0.0 3.3e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase SSB PF00436.20 ESS65535.1 - 0.018 14.8 0.0 0.027 14.3 0.0 1.4 1 1 0 1 1 1 0 Single-strand binding protein family PSI PF01437.20 ESS65537.1 - 0.007 16.5 10.4 0.007 16.5 7.2 2.8 2 1 0 2 2 2 1 Plexin repeat Zip PF02535.17 ESS65537.1 - 0.073 12.0 0.0 0.073 12.0 0.0 2.6 3 0 0 3 3 3 0 ZIP Zinc transporter gpUL132 PF11359.3 ESS65538.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein UL132 Rhomboid PF01694.17 ESS65539.1 - 4.1e-05 23.6 15.3 0.00027 20.9 8.7 2.8 2 1 0 2 2 2 1 Rhomboid family Sof1 PF04158.9 ESS65540.1 - 0.13 12.2 0.3 0.28 11.2 0.2 1.4 1 0 0 1 1 1 0 Sof1-like domain UPF0197 PF05251.7 ESS65544.1 - 7.3 6.9 9.3 20 5.5 0.9 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0197) Gly_kinase PF02595.10 ESS65545.1 - 1.7e-47 161.9 3.1 4.1e-44 150.8 2.1 3.5 1 1 0 1 1 1 1 Glycerate kinase family Mucin PF01456.12 ESS65550.1 - 1.8e-16 60.1 1.8 1.8e-16 60.1 1.2 1.6 2 0 0 2 2 2 1 Mucin-like glycoprotein zf-DHHC PF01529.15 ESS65550.1 - 0.018 14.4 2.9 0.023 14.0 2.0 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase PX PF00787.19 ESS65554.1 - 6.5e-06 25.9 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 PX domain Pkinase PF00069.20 ESS65556.1 - 1.2e-56 191.7 0.0 1.7e-56 191.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65556.1 - 1e-31 109.9 0.0 1.6e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65556.1 - 0.0073 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like NUC129 PF08157.6 ESS65556.1 - 0.036 13.9 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 NUC129 domain Kdo PF06293.9 ESS65556.1 - 0.14 11.2 0.0 0.29 10.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESS65556.1 - 0.45 9.8 0.0 0.88 8.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Zip PF02535.17 ESS65557.1 - 0.031 13.3 5.4 0.07 12.1 0.0 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter Hid1 PF12722.2 ESS65557.1 - 0.088 10.4 6.7 0.028 12.1 2.8 1.4 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Dala_Dala_lig_N PF01820.16 ESS65557.1 - 0.97 9.7 3.5 17 5.7 0.0 2.4 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus T2SM_b PF10741.4 ESS65558.1 - 0.04 13.5 0.3 0.17 11.4 0.0 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M subtype b PapD-like PF14874.1 ESS65559.1 - 0.00073 19.4 0.1 0.87 9.5 0.0 4.2 3 0 0 3 3 3 1 Flagellar-associated PapD-like Snf7 PF03357.16 ESS65559.1 - 0.033 13.5 2.8 0.079 12.3 1.9 1.5 1 0 0 1 1 1 0 Snf7 Pkinase PF00069.20 ESS65561.1 - 6e-63 212.4 0.0 7e-63 212.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65561.1 - 2.6e-31 108.6 0.0 3.3e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65561.1 - 3.4e-12 45.9 0.0 2.3e-11 43.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESS65561.1 - 3.3e-06 26.3 0.1 6e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS65561.1 - 0.048 13.3 0.1 0.15 11.7 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family UFD1 PF03152.9 ESS65562.1 - 7.2e-49 165.2 0.0 9e-49 164.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF2135 PF09906.4 ESS65563.1 - 0.17 11.8 1.3 11 6.1 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2135) PCI PF01399.22 ESS65564.1 - 4.7e-11 42.9 0.0 2.4e-10 40.6 0.0 2.1 2 0 0 2 2 2 1 PCI domain RRM_5 PF13893.1 ESS65565.1 - 0.076 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Luteo_Vpg PF01659.11 ESS65566.1 - 0.079 12.6 1.5 0.094 12.4 0.1 1.8 2 0 0 2 2 2 0 Luteovirus putative VPg genome linked protein Myb_DNA-binding PF00249.26 ESS65567.1 - 2.5e-05 24.2 0.6 5.9e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESS65567.1 - 0.00061 19.8 0.1 0.0016 18.5 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain PAS_4 PF08448.5 ESS65567.1 - 0.009 16.0 1.1 0.032 14.2 0.0 2.1 2 0 0 2 2 2 1 PAS fold NYD-SP28_assoc PF14775.1 ESS65569.1 - 3.3e-22 77.9 2.2 3.3e-22 77.9 1.5 4.6 6 0 0 6 6 6 1 Sperm tail C-terminal domain NYD-SP28 PF14772.1 ESS65569.1 - 7.5e-14 51.6 4.5 7.5e-14 51.6 3.1 5.7 3 1 1 5 5 5 1 Sperm tail DUF1759 PF03564.10 ESS65569.1 - 3.5 7.4 16.1 0.064 13.0 2.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1759) Mito_carr PF00153.22 ESS65571.1 - 3e-34 116.6 3.7 3e-13 49.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Gemini_mov PF01708.11 ESS65571.1 - 0.16 11.4 0.1 0.16 11.4 0.0 1.9 3 0 0 3 3 3 0 Geminivirus putative movement protein Methyltrn_RNA_2 PF04013.7 ESS65572.1 - 0.023 14.2 0.1 0.036 13.6 0.1 1.2 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase Metalloenzyme PF01676.13 ESS65573.1 - 1.8e-70 237.2 0.0 2e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.8 ESS65573.1 - 1.4e-61 207.7 0.0 1.8e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.17 ESS65573.1 - 0.00011 21.6 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase FtsJ PF01728.14 ESS65574.1 - 2.4e-27 96.0 0.0 3.6e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase IncA PF04156.9 ESS65575.1 - 0.00064 19.3 16.4 0.00064 19.3 11.4 2.1 1 1 1 2 2 2 1 IncA protein DUF812 PF05667.6 ESS65575.1 - 0.0042 15.6 14.1 0.0056 15.2 9.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TTKRSYEDQ PF10212.4 ESS65575.1 - 0.0043 16.0 10.1 0.0045 15.9 6.5 1.3 1 1 0 1 1 1 1 Predicted coiled-coil domain-containing protein Baculo_PEP_C PF04513.7 ESS65575.1 - 0.0077 16.0 3.4 0.0078 16.0 0.6 1.8 1 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus NUDE_C PF04880.8 ESS65575.1 - 0.013 15.8 1.5 0.013 15.8 1.1 2.1 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Mer2 PF09074.5 ESS65575.1 - 0.02 14.8 7.0 0.029 14.3 4.5 1.5 1 1 0 1 1 1 0 Mer2 AAA_32 PF13654.1 ESS65575.1 - 0.041 12.5 7.5 0.054 12.1 5.2 1.2 1 0 0 1 1 1 0 AAA domain Taxilin PF09728.4 ESS65575.1 - 0.051 12.6 18.5 0.082 11.9 12.8 1.3 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DUF972 PF06156.8 ESS65575.1 - 0.074 13.3 16.0 0.62 10.4 5.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DASH_Dam1 PF08653.5 ESS65575.1 - 0.089 12.5 0.9 11 5.9 0.1 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 Mnd1 PF03962.10 ESS65575.1 - 0.13 11.9 20.6 2.4 7.8 14.3 2.2 1 1 0 1 1 1 0 Mnd1 family DUF3584 PF12128.3 ESS65575.1 - 0.15 9.4 14.7 0.14 9.4 9.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Lipoprotein_6 PF01441.14 ESS65575.1 - 0.18 11.6 5.0 0.32 10.8 3.5 1.3 1 0 0 1 1 1 0 Lipoprotein TPR_MLP1_2 PF07926.7 ESS65575.1 - 0.24 11.1 19.3 2.1 8.0 0.5 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Ctr PF04145.10 ESS65575.1 - 0.36 10.8 1.7 0.62 10.1 1.2 1.6 1 1 0 1 1 1 0 Ctr copper transporter family FliD_C PF07195.7 ESS65575.1 - 0.39 9.9 4.8 0.22 10.8 1.7 1.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus HAUS-augmin3 PF14932.1 ESS65575.1 - 0.85 8.7 17.3 0.95 8.5 11.2 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 GAS PF13851.1 ESS65575.1 - 0.95 8.6 21.4 1.2 8.2 8.7 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TBPIP PF07106.8 ESS65575.1 - 0.98 8.9 16.1 0.32 10.5 6.8 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ApoO PF09769.4 ESS65575.1 - 1.1 8.9 2.9 17 5.0 2.0 2.1 1 1 0 1 1 1 0 Apolipoprotein O V_ATPase_I PF01496.14 ESS65575.1 - 1.4 6.7 10.4 2.1 6.1 7.2 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.3 ESS65575.1 - 1.7 8.5 20.5 0.31 10.9 6.7 2.2 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Bacillus_HBL PF05791.6 ESS65575.1 - 1.9 7.7 6.2 11 5.3 3.8 2.0 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Seryl_tRNA_N PF02403.17 ESS65575.1 - 2.5 8.1 12.1 3.8 7.5 3.9 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.6 ESS65575.1 - 3.5 7.3 19.7 1 9.1 8.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Phage_GP20 PF06810.6 ESS65575.1 - 4.4 6.7 17.0 2 7.8 5.6 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF2680 PF10925.3 ESS65575.1 - 5 7.0 7.3 17 5.3 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2680) APG6 PF04111.7 ESS65575.1 - 6.8 5.6 18.9 7.7 5.4 12.6 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 Prefoldin PF02996.12 ESS65575.1 - 7.2 6.2 12.9 2 8.0 2.2 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF342 PF03961.8 ESS65575.1 - 8.8 4.6 12.7 2 6.7 5.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Solute_trans_a PF03619.11 ESS65576.1 - 1.6e-87 293.3 16.7 2.1e-87 292.9 11.6 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF2910 PF11139.3 ESS65576.1 - 0.015 14.4 0.5 0.015 14.4 0.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2910) DUF4079 PF13301.1 ESS65576.1 - 7.3 6.5 7.7 0.6 10.1 0.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) ORC5_C PF14630.1 ESS65577.1 - 0.00033 20.2 0.1 0.00045 19.7 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 ESS65577.1 - 0.00054 20.0 0.1 0.0032 17.4 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESS65577.1 - 0.00087 19.4 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESS65577.1 - 0.0032 17.4 0.0 0.0067 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS65577.1 - 0.0085 16.9 0.0 0.025 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 ESS65577.1 - 0.011 15.3 0.2 0.042 13.5 0.1 2.1 1 1 0 1 1 1 0 NACHT domain FeoB_N PF02421.13 ESS65577.1 - 0.024 13.9 0.0 0.059 12.6 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Arch_ATPase PF01637.13 ESS65577.1 - 0.049 13.3 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_25 PF13481.1 ESS65577.1 - 0.07 12.5 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESS65577.1 - 0.079 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RecA PF00154.16 ESS65577.1 - 0.079 12.0 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein GvpL_GvpF PF06386.6 ESS65577.1 - 0.095 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF AAA_19 PF13245.1 ESS65577.1 - 0.11 12.2 0.0 0.57 9.9 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain MMR_HSR1 PF01926.18 ESS65577.1 - 0.19 11.7 0.0 0.63 10.0 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rep_fac_C PF08542.6 ESS65578.1 - 5e-18 64.8 0.0 1.2e-17 63.6 0.0 1.7 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESS65578.1 - 1.6e-15 57.1 0.0 2.4e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 ESS65578.1 - 2.7e-09 37.3 0.0 9e-09 35.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ESS65578.1 - 5.4e-06 26.4 0.1 0.0099 15.9 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain Rad17 PF03215.10 ESS65578.1 - 0.00021 20.1 0.0 0.00031 19.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 ESS65578.1 - 0.00053 19.7 0.1 0.003 17.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS65578.1 - 0.00081 19.4 0.1 0.026 14.5 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.21 ESS65578.1 - 0.0059 16.0 0.0 0.33 10.4 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_24 PF13479.1 ESS65578.1 - 0.0095 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESS65578.1 - 0.011 14.7 0.2 0.45 9.5 0.0 2.6 2 1 1 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESS65578.1 - 0.016 15.3 0.2 0.18 11.9 0.1 2.7 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.16 ESS65578.1 - 0.032 13.3 0.1 0.24 10.5 0.0 2.1 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.17 ESS65578.1 - 0.05 12.4 0.0 0.19 10.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.8 ESS65578.1 - 0.057 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.1 ESS65578.1 - 0.074 12.6 0.0 0.17 11.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESS65578.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.4 1 1 0 1 1 1 0 AAA-like domain Mito_carr PF00153.22 ESS65579.1 - 7.4e-56 185.8 0.7 2.1e-19 69.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_6 PF13405.1 ESS65580.1 - 3.9e-06 26.2 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 ESS65580.1 - 0.011 15.9 0.1 5.2 7.2 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.27 ESS65580.1 - 0.052 12.8 0.1 1.3 8.4 0.0 2.6 2 0 0 2 2 2 0 EF hand Mesd PF10185.4 ESS65580.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor AAA_33 PF13671.1 ESS65581.1 - 0.0013 18.6 0.1 0.3 10.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain ADK_lid PF05191.9 ESS65581.1 - 0.11 12.2 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 Adenylate kinase, active site lid AAA_17 PF13207.1 ESS65581.1 - 0.86 10.4 0.0 0.86 10.4 0.0 3.3 4 1 0 4 4 4 0 AAA domain Peptidase_S9 PF00326.16 ESS65583.1 - 2e-67 226.5 0.1 3.5e-67 225.7 0.0 1.4 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.10 ESS65583.1 - 9.6e-66 222.0 0.0 1.2e-65 221.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Abhydrolase_5 PF12695.2 ESS65583.1 - 0.00028 20.6 0.0 0.00064 19.4 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 ESS65583.1 - 0.00032 20.2 0.0 0.00056 19.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S15 PF02129.13 ESS65583.1 - 0.0013 18.2 1.1 0.037 13.4 0.0 2.4 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 ESS65583.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.6 ESS65583.1 - 0.046 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Lyase_aromatic PF00221.14 ESS65584.1 - 3.6e-151 503.8 0.1 4.1e-151 503.6 0.1 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase OSCP PF00213.13 ESS65585.1 - 6.5e-08 32.6 0.3 5.4e-07 29.6 0.2 2.0 1 1 0 1 1 1 1 ATP synthase delta (OSCP) subunit Adaptin_N PF01602.15 ESS65586.1 - 1.5e-106 356.8 0.0 2e-106 356.4 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 ESS65586.1 - 6.8e-18 65.1 0.0 1.4e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ESS65586.1 - 1e-11 44.9 0.5 9.2e-08 32.2 0.1 3.9 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.17 ESS65586.1 - 4.7e-08 32.4 1.9 0.0041 17.0 0.0 5.0 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.1 ESS65586.1 - 0.0011 19.3 0.1 0.041 14.3 0.0 3.6 2 1 0 2 2 2 1 HEAT-like repeat B2-adapt-app_C PF09066.5 ESS65586.1 - 0.021 14.6 0.0 0.049 13.4 0.0 1.7 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain NIF PF03031.13 ESS65587.1 - 3.8e-33 114.4 0.0 1e-32 112.9 0.0 1.7 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase SET PF00856.23 ESS65588.1 - 2.6e-11 44.0 0.1 1.2e-10 41.9 0.0 2.0 2 1 0 2 2 2 1 SET domain Argos PF11581.3 ESS65588.1 - 0.062 13.2 0.5 6.1 6.8 0.0 2.7 3 0 0 3 3 3 0 Antagonist of EGFR signalling, Argos AFG1_ATPase PF03969.11 ESS65589.1 - 4.1e-58 196.9 0.0 5.1e-55 186.7 0.0 2.9 2 1 1 3 3 3 3 AFG1-like ATPase AAA_16 PF13191.1 ESS65589.1 - 0.072 13.0 0.2 0.76 9.7 0.1 2.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 ESS65589.1 - 0.21 11.7 0.7 3.8 7.6 0.1 3.1 3 1 0 3 3 3 0 AAA domain DUF2042 PF09743.4 ESS65590.1 - 2.8e-93 312.1 1.7 4e-93 311.6 0.1 2.0 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2042) Rubis-subs-bind PF09273.6 ESS65590.1 - 0.0032 17.3 0.4 0.023 14.5 0.1 2.4 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding PCI PF01399.22 ESS65590.1 - 0.038 14.2 0.3 3.3 8.0 0.0 3.2 2 0 0 2 2 2 0 PCI domain SET PF00856.23 ESS65591.1 - 4.9e-07 30.1 0.0 0.0029 17.9 0.0 2.3 2 0 0 2 2 2 2 SET domain DUF3406 PF11886.3 ESS65591.1 - 0.13 11.0 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3406) DUF2453 PF10507.4 ESS65592.1 - 3.5e-44 149.1 5.7 6.4e-44 148.2 4.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2453) EF-hand_7 PF13499.1 ESS65592.1 - 1.2e-08 34.9 0.7 0.00021 21.3 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 ESS65592.1 - 7.2e-07 28.5 1.6 0.00051 19.7 0.0 3.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.27 ESS65592.1 - 2.7e-06 26.2 0.1 0.0053 15.9 0.0 3.3 4 0 0 4 4 4 2 EF hand AAA_18 PF13238.1 ESS65593.1 - 1.2e-11 44.9 0.0 2.9e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS65593.1 - 6e-11 42.4 0.0 1.3e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_lig_T4_1 PF09511.5 ESS65593.1 - 7.1e-11 42.0 0.0 1.4e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 RNA ligase AAA_17 PF13207.1 ESS65593.1 - 0.00027 21.7 0.0 0.003 18.3 0.0 2.8 3 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 ESS65593.1 - 0.00068 18.7 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.7 ESS65593.1 - 0.0041 16.7 0.0 0.0071 15.9 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.1 ESS65593.1 - 0.024 14.3 0.2 0.12 12.0 0.0 2.2 2 0 0 2 2 2 0 Part of AAA domain AAA_25 PF13481.1 ESS65593.1 - 0.026 13.9 0.0 0.065 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 ESS65593.1 - 0.057 12.4 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus SRP54 PF00448.17 ESS65593.1 - 0.066 12.6 0.0 0.28 10.5 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NACHT PF05729.7 ESS65593.1 - 0.08 12.5 0.1 1.1 8.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 ESS65593.1 - 0.084 13.0 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS65593.1 - 0.089 12.9 0.0 0.32 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 ESS65593.1 - 0.15 11.5 0.2 0.73 9.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.4 ESS65593.1 - 0.18 10.7 0.0 0.3 10.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Ank_5 PF13857.1 ESS65594.1 - 0.03 14.5 0.2 0.098 12.9 0.1 1.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.25 ESS65594.1 - 0.12 12.2 0.2 0.34 10.7 0.1 1.7 1 0 0 1 1 1 0 Ankyrin repeat Bromodomain PF00439.20 ESS65596.1 - 3.9e-14 52.3 0.0 6.2e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain Nucleoporin_N PF08801.6 ESS65597.1 - 1.2e-57 195.6 0.0 1.8e-57 194.9 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like LRR_4 PF12799.2 ESS65598.1 - 9.6e-08 31.4 5.1 0.00011 21.7 0.6 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65598.1 - 0.0013 18.4 0.3 0.0031 17.2 0.2 1.7 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.1 ESS65598.1 - 0.1 12.1 0.0 1.8 8.1 0.0 2.0 1 1 1 2 2 2 0 Leucine-rich repeat LRR_3 PF07725.7 ESS65598.1 - 0.83 9.5 3.2 0.83 9.5 0.3 2.6 3 0 0 3 3 3 0 Leucine Rich Repeat Cpn60_TCP1 PF00118.19 ESS65599.1 - 1.1e-136 456.3 6.4 1.2e-136 456.1 4.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_L1 PF00687.16 ESS65600.1 - 4.1e-15 55.7 0.0 5.3e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family zf-H2C2_2 PF13465.1 ESS65601.1 - 0.0013 18.9 5.4 0.37 11.1 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 ESS65601.1 - 0.0016 18.6 8.5 0.0075 16.5 0.4 2.8 2 1 1 3 3 3 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESS65601.1 - 0.0081 16.2 1.9 3 8.0 0.0 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 ESS65601.1 - 0.014 15.7 3.4 0.17 12.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger FYVE PF01363.16 ESS65601.1 - 0.042 13.7 2.8 0.88 9.5 0.3 2.4 2 0 0 2 2 2 0 FYVE zinc finger CpXC PF14353.1 ESS65601.1 - 0.043 13.7 0.1 8.3 6.3 0.0 2.4 2 0 0 2 2 2 0 CpXC protein zinc-ribbons_6 PF07191.7 ESS65601.1 - 0.2 11.4 2.0 1.4 8.8 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbons zf-C2H2_jaz PF12171.3 ESS65601.1 - 0.47 10.6 3.1 23 5.2 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 ESS65601.1 - 0.69 10.0 4.7 7.9 6.6 0.1 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 ESS65601.1 - 0.88 9.5 13.3 0.1 12.5 0.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.2 ESS65601.1 - 3.1 8.1 5.7 3.1 8.1 0.3 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Thioredoxin PF00085.15 ESS65602.1 - 2.3e-44 149.3 0.0 2.2e-27 94.7 0.0 4.1 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.1 ESS65602.1 - 5e-30 104.6 0.0 6.2e-20 71.7 0.0 3.2 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 ESS65602.1 - 1.6e-11 44.4 0.1 0.0007 19.7 0.1 3.8 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESS65602.1 - 1.6e-06 28.0 0.0 3e-05 23.9 0.0 2.8 4 0 0 4 4 4 1 Thioredoxin-like Thioredoxin_8 PF13905.1 ESS65602.1 - 1e-05 25.5 0.2 0.05 13.7 0.0 3.8 3 1 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 ESS65602.1 - 1.6e-05 24.5 0.0 0.0012 18.5 0.0 2.6 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 ESS65602.1 - 5e-05 22.8 0.0 0.0048 16.4 0.0 2.5 2 1 0 2 2 2 1 Redoxin Calsequestrin PF01216.12 ESS65602.1 - 0.013 14.3 0.2 0.028 13.2 0.0 1.6 2 0 0 2 2 2 0 Calsequestrin Thioredoxin_9 PF14595.1 ESS65602.1 - 0.02 14.4 0.0 0.061 12.8 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_4 PF13462.1 ESS65602.1 - 0.039 13.9 0.0 3.8 7.4 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin HyaE PF07449.6 ESS65602.1 - 0.042 13.7 0.0 1.1 9.1 0.0 2.8 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE DUF1894 PF08979.6 ESS65602.1 - 0.063 13.3 0.3 4 7.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1894) TraF PF13728.1 ESS65602.1 - 0.11 12.0 0.0 2.1 7.7 0.0 2.5 3 0 0 3 3 3 0 F plasmid transfer operon protein Methyltransf_23 PF13489.1 ESS65605.1 - 0.094 12.4 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain eIF-3c_N PF05470.7 ESS65606.1 - 1.1e-22 79.8 18.4 8.6e-20 70.3 5.6 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 ESS65606.1 - 0.0088 16.3 1.5 0.062 13.6 0.0 3.0 3 0 0 3 3 3 1 PCI domain MutS_III PF05192.13 ESS65606.1 - 0.03 14.0 0.0 0.09 12.5 0.0 2.0 1 1 0 1 1 1 0 MutS domain III MOZ_SAS PF01853.13 ESS65607.1 - 2.8e-44 150.6 0.0 3.8e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_1 PF00583.19 ESS65607.1 - 0.014 15.3 0.0 0.035 14.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESS65607.1 - 0.026 14.6 0.2 0.07 13.3 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain zf-C2H2_4 PF13894.1 ESS65607.1 - 0.2 12.0 1.6 1.6 9.2 0.4 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger BNR_3 PF13859.1 ESS65608.1 - 1.3e-58 198.5 0.1 1.7e-58 198.1 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS65608.1 - 0.028 14.2 1.1 0.18 11.7 0.2 2.9 2 0 0 2 2 2 0 BNR/Asp-box repeat Tr-sialidase_C PF11052.3 ESS65609.1 - 2.9e-11 43.0 10.4 4.9e-11 42.2 7.2 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS65609.1 - 0.00031 21.0 0.2 0.0011 19.2 0.0 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily SRP-alpha_N PF04086.8 ESS65609.1 - 0.024 14.0 1.0 0.029 13.7 0.2 1.5 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Menin PF05053.8 ESS65609.1 - 1.1 7.3 7.2 1.6 6.7 5.0 1.3 1 0 0 1 1 1 0 Menin PI3Ka PF00613.15 ESS65610.1 - 7.2e-50 168.7 0.8 1.3e-49 167.8 0.6 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 ESS65610.1 - 2.1e-40 138.6 0.1 3.4e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 ESS65610.1 - 9.7e-09 35.1 0.1 2.3e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.13 ESS65610.1 - 6e-07 29.3 0.1 1.3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain DUF1944 PF09175.5 ESS65610.1 - 0.17 11.5 0.0 0.35 10.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1944) SNF2_N PF00176.18 ESS65612.1 - 2e-29 102.3 0.0 3.9e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Tet_JBP PF12851.2 ESS65612.1 - 3.4e-26 91.5 0.1 6.2e-26 90.7 0.1 1.4 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily Helicase_C PF00271.26 ESS65612.1 - 6.7e-14 51.5 0.0 1.6e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS65612.1 - 2.5e-06 27.1 0.0 5.4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS65612.1 - 3.3e-06 27.0 0.0 5.2e-05 23.1 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit cNMP_binding PF00027.24 ESS65613.1 - 2.1e-10 40.2 0.2 0.00087 19.0 0.0 3.2 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain LRR_4 PF12799.2 ESS65614.1 - 8e-23 79.6 0.0 8.8e-07 28.4 0.0 7.2 5 3 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65614.1 - 8e-15 54.3 2.3 1.9e-05 24.3 0.2 5.1 4 1 1 5 5 5 4 Leucine rich repeat LRR_6 PF13516.1 ESS65614.1 - 8.5e-15 53.1 13.5 0.0023 17.8 0.1 9.7 8 2 1 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.28 ESS65614.1 - 1.8e-10 39.3 12.8 3.8 7.9 0.0 9.5 8 1 0 8 8 8 3 Leucine Rich Repeat LRR_7 PF13504.1 ESS65614.1 - 0.00059 19.6 17.9 51 4.7 0.1 9.3 9 1 0 9 9 9 0 Leucine rich repeat DnaJ PF00226.26 ESS65617.1 - 4e-06 26.4 0.0 1.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain CH PF00307.26 ESS65618.1 - 2.1e-09 37.3 0.0 6.6e-09 35.7 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain DnaJ PF00226.26 ESS65619.1 - 2.8e-14 52.5 1.2 5e-14 51.7 0.8 1.4 1 0 0 1 1 1 1 DnaJ domain IU_nuc_hydro PF01156.14 ESS65621.1 - 3.4e-76 256.4 0.0 4.1e-76 256.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF1955 PF09205.5 ESS65621.1 - 0.1 12.1 0.1 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) MOZ_SAS PF01853.13 ESS65622.1 - 4e-61 205.5 0.0 6.7e-61 204.8 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 ESS65622.1 - 3.7e-10 39.3 1.5 3.8e-10 39.2 0.1 1.8 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.19 ESS65622.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family zf-C2H2_4 PF13894.1 ESS65622.1 - 0.08 13.3 2.1 0.27 11.6 1.5 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger Sulfolobus_pRN PF05584.6 ESS65622.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein Chromo PF00385.19 ESS65623.1 - 0.012 15.2 0.0 0.032 13.9 0.0 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.1 ESS65623.1 - 0.052 13.4 0.1 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Thioredoxin_8 PF13905.1 ESS65625.1 - 6.4e-16 58.2 0.0 1.1e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 ESS65625.1 - 0.00014 21.4 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESS65625.1 - 0.042 13.4 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Redoxin KH_1 PF00013.24 ESS65626.1 - 2.1e-37 126.5 7.7 7.6e-10 38.3 0.0 7.3 7 0 0 7 7 7 4 KH domain KH_3 PF13014.1 ESS65626.1 - 5.6e-26 89.6 3.6 2.8e-05 23.6 0.0 5.7 5 0 0 5 5 5 4 KH domain KH_2 PF07650.12 ESS65626.1 - 4.2e-06 26.2 11.9 0.21 11.1 0.2 5.7 4 1 1 5 5 5 3 KH domain LMBR1 PF04791.11 ESS65626.1 - 0.69 8.4 0.7 0.94 7.9 0.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein COG2 PF06148.6 ESS65626.1 - 1.3 8.9 11.3 7 6.5 1.6 2.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Alba PF01918.16 ESS65626.1 - 1.5 8.4 3.9 9 5.9 0.4 3.3 3 1 0 3 3 3 0 Alba VASP_tetra PF08776.6 ESS65626.1 - 1.6 8.0 8.5 2.6 7.4 0.2 3.3 3 0 0 3 3 3 0 VASP tetramerisation domain TBPIP PF07106.8 ESS65626.1 - 4.2 6.8 14.9 1.4 8.4 7.2 2.3 1 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Prp19 PF08606.6 ESS65626.1 - 8.9 6.1 12.0 6.5 6.5 0.1 3.8 4 1 0 4 4 4 0 Prp19/Pso4-like DUF4201 PF13870.1 ESS65627.1 - 4.5e-37 127.2 26.5 4.5e-37 127.2 18.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Ribosomal_60s PF00428.14 ESS65627.1 - 2.5 8.5 12.5 2 8.8 7.1 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein PX PF00787.19 ESS65628.1 - 1.3e-11 44.2 0.1 6.7e-11 41.9 0.0 2.2 2 0 0 2 2 2 1 PX domain Sec5 PF15469.1 ESS65629.1 - 4e-05 23.4 0.0 0.00017 21.3 0.0 2.1 2 0 0 2 2 2 1 Exocyst complex component Sec5 VWA_3 PF13768.1 ESS65630.1 - 6e-41 139.7 0.2 1.8e-40 138.1 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VIT_2 PF13757.1 ESS65630.1 - 0.0016 17.8 0.0 0.0035 16.7 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.1 ESS65630.1 - 0.0023 18.0 0.0 0.0042 17.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Fringe PF02434.11 ESS65631.1 - 2.8e-05 23.4 0.2 0.00048 19.4 0.1 2.6 1 1 0 1 1 1 1 Fringe-like Proteasome PF00227.21 ESS65635.1 - 2.2e-44 151.0 0.0 2.9e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit AA_permease_2 PF13520.1 ESS65636.1 - 1.4e-32 112.7 42.8 2e-32 112.2 29.6 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESS65636.1 - 1.6e-09 36.6 38.0 3.2e-09 35.6 26.3 1.4 1 1 0 1 1 1 1 Amino acid permease IPK PF03770.11 ESS65638.1 - 5.4e-43 146.9 0.1 5.4e-43 146.9 0.0 1.8 2 0 0 2 2 2 1 Inositol polyphosphate kinase PALP PF00291.20 ESS65639.1 - 1.8e-13 50.4 0.0 4e-13 49.2 0.0 1.5 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Thr_synth_N PF14821.1 ESS65639.1 - 2.1e-09 37.2 0.0 4.7e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus Bromodomain PF00439.20 ESS65640.1 - 7.7e-11 41.7 0.0 1.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain zf-CW PF07496.10 ESS65640.1 - 5.7e-08 32.3 4.4 1.2e-07 31.3 3.0 1.5 1 0 0 1 1 1 1 CW-type Zinc Finger Choline_transpo PF04515.7 ESS65643.1 - 1.6e-63 214.5 30.0 1.6e-63 214.5 20.8 1.7 1 1 1 2 2 2 1 Plasma-membrane choline transporter SKG6 PF08693.5 ESS65643.1 - 0.83 9.0 8.5 0.052 12.8 0.5 3.1 3 0 0 3 3 3 0 Transmembrane alpha-helix domain DUF1253 PF06862.7 ESS65646.1 - 4.8e-213 707.4 0.0 8.6e-132 439.6 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1253) DEAD PF00270.24 ESS65646.1 - 5.9e-07 29.1 0.0 0.27 10.7 0.0 3.3 3 0 0 3 3 3 2 DEAD/DEAH box helicase CobA_CobO_BtuR PF02572.10 ESS65646.1 - 0.00027 20.6 0.6 0.83 9.2 0.0 2.4 2 0 0 2 2 2 2 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Gp_UL130 PF11668.3 ESS65646.1 - 0.044 13.3 0.1 8.4 5.8 0.0 2.4 2 0 0 2 2 2 0 HCMV glycoprotein pUL130 HDNR PF15115.1 ESS65646.1 - 0.063 13.2 2.7 3.9 7.3 0.1 2.9 4 0 0 4 4 4 0 Domain of unknown function with conserved HDNR motif PBP1_TM PF14812.1 ESS65646.1 - 0.32 11.3 7.6 0.67 10.2 5.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Dzip-like_N PF13815.1 ESS65647.1 - 6.6e-41 138.8 3.2 6.6e-41 138.8 2.2 2.6 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal zf-C2H2_4 PF13894.1 ESS65647.1 - 0.0014 18.7 0.3 0.0039 17.4 0.2 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESS65647.1 - 0.0019 18.4 0.4 0.0019 18.4 0.3 2.0 2 0 0 2 2 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESS65647.1 - 0.0032 17.5 0.0 0.0096 16.0 0.0 1.8 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.2 ESS65647.1 - 0.015 15.4 2.3 0.16 12.0 0.0 3.0 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Nnf1 PF03980.9 ESS65647.1 - 0.12 12.3 12.6 0.065 13.2 0.7 3.6 3 1 0 3 3 3 0 Nnf1 Nrf1_activ_bdg PF10492.4 ESS65647.1 - 0.41 11.1 7.5 8.9 6.8 1.1 3.1 2 1 0 2 2 2 0 Nrf1 activator activation site binding domain NinG PF05766.7 ESS65647.1 - 0.73 9.5 12.3 4.1 7.1 3.0 2.4 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein DUF2205 PF10224.4 ESS65647.1 - 1.2 8.7 13.0 0.12 11.9 1.0 2.8 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) DUF106 PF01956.11 ESS65647.1 - 1.3 8.5 3.9 38 3.7 2.7 2.3 2 0 0 2 2 2 0 Integral membrane protein DUF106 DivIC PF04977.10 ESS65647.1 - 3.1 7.3 22.4 1.8 8.1 0.5 3.6 3 0 0 3 3 3 0 Septum formation initiator V_ATPase_I PF01496.14 ESS65647.1 - 7.9 4.1 7.6 0.93 7.2 0.9 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family mRNA_triPase PF02940.10 ESS65649.1 - 3.7e-11 43.1 0.0 9.6e-11 41.8 0.0 1.6 1 1 0 1 1 1 1 mRNA capping enzyme, beta chain Pyr_redox PF00070.22 ESS65650.1 - 4.3e-11 43.0 0.0 9.7e-06 25.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESS65650.1 - 7.1e-08 32.5 0.0 0.011 15.6 0.0 3.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 ESS65650.1 - 1.3e-05 24.9 0.0 0.0001 22.0 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.7 ESS65650.1 - 0.00013 20.9 0.0 0.068 12.0 0.0 3.0 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 ESS65650.1 - 0.00016 21.8 0.0 0.0023 18.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESS65650.1 - 0.0002 20.3 0.0 0.088 11.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 ESS65650.1 - 0.00042 19.7 0.0 0.023 14.0 0.0 2.4 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 ESS65650.1 - 0.0011 18.6 0.0 0.21 11.2 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.1 ESS65650.1 - 0.0021 18.0 0.0 3.5 7.7 0.0 3.3 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 ESS65650.1 - 0.003 17.7 0.0 2.4 8.4 0.0 2.5 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_9 PF13454.1 ESS65650.1 - 0.013 15.2 0.0 1 9.1 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding Semialdhyde_dh PF01118.19 ESS65650.1 - 0.021 15.1 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.13 ESS65650.1 - 0.1 12.6 0.0 20 5.2 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain Ldh_1_N PF00056.18 ESS65650.1 - 0.11 12.3 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain K_oxygenase PF13434.1 ESS65650.1 - 0.11 11.4 0.0 0.3 9.9 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 ESS65650.1 - 0.17 10.9 0.0 5 6.0 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain F-box-like PF12937.2 ESS65651.1 - 0.00049 19.7 0.8 0.00049 19.7 0.6 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESS65651.1 - 0.00054 19.5 0.1 0.0022 17.6 0.0 2.0 1 0 0 1 1 1 1 F-box domain Nudc_N PF14050.1 ESS65652.1 - 3.7e-18 65.2 0.6 8.1e-18 64.1 0.4 1.6 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.11 ESS65652.1 - 7.7e-17 61.6 0.0 1.3e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 CS domain Fig1 PF12351.3 ESS65652.1 - 0.62 9.9 3.3 1.1 9.1 2.3 1.3 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 FAA_hydrolase_N PF09298.6 ESS65652.1 - 1.4 8.9 4.4 14 5.7 0.7 2.6 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal OAD_gamma PF04277.8 ESS65652.1 - 3.1 8.2 0.0 3.1 8.2 0.0 3.4 3 1 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain UDPGT PF00201.13 ESS65653.1 - 1.2e-25 90.0 0.0 4.7e-25 88.0 0.0 1.9 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESS65653.1 - 0.00057 19.5 0.0 0.00082 19.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESS65653.1 - 0.0011 18.2 0.0 0.0029 16.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 1 TRAP-gamma PF07074.7 ESS65654.1 - 0.01 15.3 6.7 0.063 12.7 0.3 2.1 1 1 1 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Cytochrom_B_N PF00033.14 ESS65654.1 - 0.014 14.7 0.6 0.018 14.3 0.4 1.2 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB DUF1430 PF07242.6 ESS65654.1 - 0.11 12.5 1.9 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) DUF3022 PF11226.3 ESS65655.1 - 0.12 12.2 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3022) Miro PF08477.8 ESS65656.1 - 3.6e-05 24.2 0.0 4.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS65656.1 - 0.00028 20.1 0.0 0.00074 18.7 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.1 ESS65656.1 - 0.022 14.7 0.1 0.03 14.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.12 ESS65656.1 - 0.051 13.1 0.1 0.62 9.5 0.0 2.2 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.15 ESS65656.1 - 0.083 11.5 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_28 PF13521.1 ESS65656.1 - 0.097 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESS65656.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESS65656.1 - 0.12 12.6 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Ribosomal_L12 PF00542.14 ESS65657.1 - 5.1e-16 58.4 1.6 5.1e-16 58.4 1.1 1.9 1 1 1 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.14 ESS65657.1 - 1.8e-05 25.0 3.1 1.8e-05 25.0 2.2 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein PepSY_2 PF13670.1 ESS65657.1 - 0.082 12.8 4.0 0.22 11.4 2.8 1.7 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain HIT PF01230.18 ESS65658.1 - 2.2e-24 85.8 0.6 2.8e-24 85.5 0.4 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ESS65658.1 - 2e-14 53.8 0.0 2.4e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 ESS65658.1 - 1.5e-05 24.6 0.3 3.1e-05 23.6 0.1 1.6 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 PUF PF00806.14 ESS65659.1 - 7.5e-36 119.6 1.6 0.00042 19.6 0.0 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat GST_N_3 PF13417.1 ESS65661.1 - 6.2e-10 39.1 0.0 2.1e-09 37.4 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESS65661.1 - 1.2e-09 38.1 0.0 2.7e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESS65661.1 - 4.7e-08 32.9 0.0 3e-07 30.3 0.0 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESS65661.1 - 0.008 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESS65661.1 - 0.034 14.0 0.0 0.076 12.9 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESS65661.1 - 0.1 13.0 0.0 0.5 10.8 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain NOT2_3_5 PF04153.13 ESS65662.1 - 1.6e-24 86.2 0.6 1.6e-24 86.2 0.4 2.6 2 1 0 2 2 1 1 NOT2 / NOT3 / NOT5 family PAT1 PF09770.4 ESS65662.1 - 0.036 12.3 33.8 0.046 11.9 23.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 ESS65662.1 - 0.079 12.8 26.1 0.12 12.2 18.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_transf_15 PF01793.11 ESS65662.1 - 0.13 11.1 2.6 0.2 10.5 1.8 1.3 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Zip PF02535.17 ESS65662.1 - 0.29 10.0 2.8 0.41 9.6 2.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.9 ESS65662.1 - 0.36 10.5 15.0 0.57 9.8 10.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.11 ESS65662.1 - 0.5 10.2 3.3 0.8 9.5 2.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Med13_N PF11597.3 ESS65662.1 - 1.5 7.4 13.2 2.3 6.8 9.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal Band_3_cyto PF07565.8 ESS65662.1 - 1.7 8.1 7.2 2.5 7.5 5.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FimP PF09766.4 ESS65662.1 - 2.2 7.2 16.9 3.4 6.6 11.7 1.3 1 0 0 1 1 1 0 Fms-interacting protein Serinc PF03348.10 ESS65662.1 - 4 6.0 5.4 6.7 5.3 3.8 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.12 ESS65662.1 - 8.3 5.1 5.7 12 4.5 3.9 1.1 1 0 0 1 1 1 0 Presenilin Adenine_deam_C PF13382.1 ESS65663.1 - 0.043 12.9 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain Myotub-related PF06602.9 ESS65666.1 - 5.7e-67 225.9 0.2 4e-40 137.6 0.1 2.3 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Vma12 PF11712.3 ESS65667.1 - 0.0001 22.0 0.1 0.00027 20.6 0.0 1.6 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase UPF0104 PF03706.8 ESS65667.1 - 0.0067 15.7 0.7 0.77 8.9 0.0 2.1 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0104) SAC3_GANP PF03399.11 ESS65670.1 - 2.2e-06 27.3 0.2 0.017 14.7 0.0 2.4 2 0 0 2 2 2 2 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Peptidase_M50 PF02163.17 ESS65671.1 - 0.037 12.9 0.4 0.082 11.8 0.1 1.7 2 0 0 2 2 2 0 Peptidase family M50 DUF4544 PF15077.1 ESS65672.1 - 1.1 8.7 4.6 7 6.0 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4544) SET PF00856.23 ESS65674.1 - 7.3e-10 39.3 0.0 4.8e-08 33.4 0.0 2.5 1 1 0 1 1 1 1 SET domain UBA PF00627.26 ESS65674.1 - 0.011 15.5 0.0 3 7.8 0.0 2.4 2 0 0 2 2 2 0 UBA/TS-N domain DEAD PF00270.24 ESS65675.1 - 1.1e-07 31.4 0.0 2.4e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HA2 PF04408.18 ESS65675.1 - 3.6e-07 30.1 0.0 1.1e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS65675.1 - 1.2e-06 28.3 0.0 2.9e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Peptidase_C14 PF00656.17 ESS65676.1 - 4.8e-30 105.0 0.1 5.9e-30 104.7 0.1 1.0 1 0 0 1 1 1 1 Caspase domain tRNA-synt_1e PF01406.14 ESS65677.1 - 2e-108 362.0 0.0 2.8e-108 361.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 ESS65677.1 - 6e-05 21.8 0.1 0.007 15.0 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ESS65677.1 - 0.0099 13.9 0.0 0.15 10.0 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (I, L, M and V) Peptidase_C1 PF00112.18 ESS65678.1 - 9.6e-43 146.6 1.1 1.2e-42 146.3 0.7 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 ESS65678.1 - 0.17 10.3 0.1 0.23 9.9 0.1 1.1 1 0 0 1 1 1 0 Peptidase C1-like family Beta-lactamase PF00144.19 ESS65679.1 - 3.7e-06 26.1 0.0 5.9e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase MAPEG PF01124.13 ESS65680.1 - 0.027 14.0 0.3 0.082 12.5 0.2 1.8 1 0 0 1 1 1 0 MAPEG family ABC2_membrane_3 PF12698.2 ESS65681.1 - 0.26 10.2 21.2 0.58 9.1 14.7 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA PF00004.24 ESS65682.1 - 2.9e-35 121.3 0.0 4.7e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESS65682.1 - 0.004 17.0 0.0 0.0059 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 ESS65682.1 - 0.042 13.5 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF1778 PF08681.6 ESS65683.1 - 0.062 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) UCH PF00443.24 ESS65684.1 - 9.5e-31 106.8 0.0 4.9e-30 104.5 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS65684.1 - 5.9e-08 32.5 0.0 0.0001 21.8 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase HTH_36 PF13730.1 ESS65685.1 - 0.0039 17.2 0.0 0.0089 16.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.1 ESS65685.1 - 0.26 11.1 2.1 0.23 11.2 0.2 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Nucleoplasmin PF03066.10 ESS65686.1 - 0.53 9.7 5.5 0.92 9.0 3.8 1.3 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 ESS65686.1 - 0.68 10.2 11.3 1.8 8.9 7.8 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.8 ESS65686.1 - 0.99 8.9 7.3 1.7 8.2 5.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.9 ESS65686.1 - 2.6 5.9 7.5 3.6 5.5 5.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_22 PF03901.12 ESS65687.1 - 2.4e-54 184.9 21.3 1.2e-53 182.5 14.8 1.7 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family LRR_4 PF12799.2 ESS65688.1 - 2e-17 62.4 15.9 8.8e-06 25.2 0.0 4.4 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESS65688.1 - 3.9e-09 35.2 7.7 7.3 7.2 0.0 7.4 7 0 0 7 7 7 2 Leucine rich repeat LRR_8 PF13855.1 ESS65688.1 - 5e-09 35.7 6.6 0.00054 19.6 0.1 4.8 4 2 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 ESS65688.1 - 3.1e-08 32.8 0.6 5.6 7.3 0.0 5.6 4 1 1 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.28 ESS65688.1 - 1.8e-07 30.2 12.3 2.3 8.5 0.0 7.7 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.1 ESS65688.1 - 0.12 11.9 0.4 10 5.6 0.1 2.4 1 1 0 2 2 2 0 Leucine-rich repeat Aph-1 PF06105.7 ESS65689.1 - 1.2e-07 31.1 11.1 1.2e-07 31.1 7.7 1.8 2 0 0 2 2 2 1 Aph-1 protein Tropomyosin PF00261.15 ESS65690.1 - 6.2e-05 22.1 19.2 6.2e-05 22.1 13.3 5.5 2 2 4 6 6 6 1 Tropomyosin Reo_sigmaC PF04582.7 ESS65690.1 - 0.00063 19.0 27.8 0.15 11.1 1.0 5.8 2 1 3 6 6 6 4 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 ESS65690.1 - 0.009 15.8 0.3 0.009 15.8 0.2 6.2 5 1 3 8 8 8 2 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.6 ESS65690.1 - 0.017 15.0 0.8 89 3.0 0.0 6.0 6 1 0 6 6 6 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.3 ESS65690.1 - 0.34 10.6 23.0 3 7.6 0.3 6.6 4 2 2 6 6 6 0 Protein of unknown function (DUF2730) AAA_13 PF13166.1 ESS65690.1 - 0.34 9.2 32.3 0.11 10.8 3.5 3.9 1 1 3 4 4 4 0 AAA domain DUF948 PF06103.6 ESS65690.1 - 0.7 9.7 6.5 1.7 8.5 0.0 4.6 2 2 5 7 7 7 0 Bacterial protein of unknown function (DUF948) GP41 PF00517.12 ESS65690.1 - 1.7 8.1 9.0 2.9 7.4 0.1 4.4 4 1 0 5 5 5 0 Retroviral envelope protein NPV_P10 PF05531.7 ESS65690.1 - 2.6 8.3 12.3 1.2 9.3 0.0 5.6 4 2 1 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 ESS65690.1 - 2.7 7.8 28.4 0.4 10.4 0.0 7.1 1 1 10 11 11 11 0 Protein of unknown function (DUF1664) FYVE PF01363.16 ESS65691.1 - 1.1e-08 34.8 7.7 1.1e-08 34.8 5.4 2.1 2 0 0 2 2 2 1 FYVE zinc finger IBR PF01485.16 ESS65691.1 - 0.00076 19.3 2.7 0.003 17.3 1.9 2.0 1 0 0 1 1 1 1 IBR domain Spc42p PF11544.3 ESS65691.1 - 5 7.1 11.2 0.35 10.8 0.4 3.5 4 0 0 4 4 4 0 Spindle pole body component Spc42p Plus-3 PF03126.13 ESS65692.1 - 3.9e-11 42.9 0.1 7.8e-11 41.9 0.1 1.5 1 1 0 1 1 1 1 Plus-3 domain zf-C3HC4_3 PF13920.1 ESS65692.1 - 1.3e-09 37.5 17.1 2.2e-09 36.8 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS65692.1 - 0.021 14.8 19.6 0.047 13.7 13.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.4 ESS65692.1 - 0.032 14.4 6.1 0.07 13.3 4.2 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Pox_A11 PF05061.8 ESS65695.1 - 0.0026 16.9 0.6 0.0026 16.9 0.4 1.9 2 0 0 2 2 2 1 Poxvirus A11 Protein DAP3 PF10236.4 ESS65696.1 - 9.2e-31 106.9 0.0 1.4e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Arch_ATPase PF01637.13 ESS65696.1 - 0.0076 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ESS65696.1 - 0.0082 16.0 0.0 0.16 11.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain NACHT PF05729.7 ESS65696.1 - 0.013 15.1 0.0 0.048 13.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.1 ESS65696.1 - 0.029 14.1 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_16 PF13191.1 ESS65696.1 - 0.051 13.5 0.0 0.15 12.0 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_35 PF14516.1 ESS65696.1 - 0.076 11.6 0.0 0.42 9.1 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain ResIII PF04851.10 ESS65696.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESS65696.1 - 0.14 12.3 0.0 0.53 10.4 0.0 1.9 2 1 0 2 2 2 0 AAA domain Proteasome PF00227.21 ESS65697.1 - 5.3e-42 143.2 1.0 6.7e-42 142.9 0.7 1.1 1 0 0 1 1 1 1 Proteasome subunit IF-2B PF01008.12 ESS65698.1 - 1.5e-17 63.5 2.8 8.3e-16 57.7 1.0 3.2 2 2 0 2 2 2 1 Initiation factor 2 subunit family DUF2207 PF09972.4 ESS65698.1 - 3.4 6.1 5.6 5.9 5.3 3.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HEAT PF02985.17 ESS65699.1 - 5.5e-07 29.1 9.2 8.4 6.7 0.0 7.2 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.1 ESS65699.1 - 1.6e-06 28.2 0.1 0.0086 16.3 0.1 4.5 3 1 3 6 6 6 3 HEAT repeats HEAT_EZ PF13513.1 ESS65699.1 - 0.065 13.7 2.6 21 5.7 0.2 4.7 3 1 1 4 4 4 0 HEAT-like repeat Dak2 PF02734.12 ESS65699.1 - 0.17 11.5 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 DAK2 domain Arm PF00514.18 ESS65699.1 - 0.32 10.8 3.1 8.7 6.3 0.0 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF2910 PF11139.3 ESS65700.1 - 0.0096 15.0 0.0 0.0098 15.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2910) DUF4366 PF14283.1 ESS65700.1 - 0.06 12.7 0.2 0.11 11.8 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) ETRAMP PF09716.5 ESS65700.1 - 0.061 13.2 0.0 0.078 12.9 0.0 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Aa_trans PF01490.13 ESS65700.1 - 0.076 11.4 0.4 0.093 11.1 0.3 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein Bax1-I PF01027.15 ESS65700.1 - 0.12 12.0 0.1 0.13 11.8 0.1 1.0 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Lig_chan PF00060.21 ESS65700.1 - 0.14 11.8 0.2 0.57 9.8 0.0 1.8 1 1 1 2 2 2 0 Ligand-gated ion channel Aa_trans PF01490.13 ESS65703.1 - 1.7e-53 181.6 36.4 2e-53 181.3 25.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS65703.1 - 3e-11 42.7 16.0 3e-11 42.7 11.1 2.2 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.1 ESS65703.1 - 9.9 4.5 42.3 37 2.6 29.3 1.8 1 1 0 1 1 1 0 Amino acid permease Rhodanese PF00581.15 ESS65705.1 - 6.1e-10 39.4 0.0 6.9e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Sec7 PF01369.15 ESS65706.1 - 4.1e-30 104.8 0.0 7.5e-30 104.0 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESS65706.1 - 4.9e-18 65.1 2.5 4.9e-18 65.1 1.7 1.9 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal HBS1_N PF08938.5 ESS65707.1 - 5 7.3 7.2 10 6.3 0.0 3.0 3 0 0 3 3 3 0 HBS1 N-terminus Mononeg_mRNAcap PF14318.1 ESS65708.1 - 0.046 12.7 0.2 0.063 12.3 0.2 1.1 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V Menin PF05053.8 ESS65708.1 - 1.4 6.9 3.1 1.9 6.5 2.1 1.1 1 0 0 1 1 1 0 Menin Mononeg_mRNAcap PF14318.1 ESS65709.1 - 0.089 11.8 0.3 0.14 11.1 0.2 1.2 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V Zip PF02535.17 ESS65711.1 - 0.068 12.1 2.3 0.07 12.1 1.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 ESS65711.1 - 1.4 8.2 8.2 1.5 8.1 5.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNase_T PF00929.19 ESS65712.1 - 2.4e-14 53.9 0.0 8.1e-13 48.9 0.0 2.1 1 1 0 1 1 1 1 Exonuclease RRM_1 PF00076.17 ESS65714.1 - 1.5e-21 75.7 1.2 5.3e-09 35.5 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS65714.1 - 2.4e-18 65.8 1.0 6e-08 32.5 0.0 3.3 3 1 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS65714.1 - 3.7e-10 39.5 0.0 1.9e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RPN7 PF10602.4 ESS65715.1 - 3.8e-49 166.4 0.9 8.3e-49 165.3 0.1 1.9 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 ESS65715.1 - 1.3e-12 47.9 0.0 3.5e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 PCI domain SAC3_GANP PF03399.11 ESS65715.1 - 0.0005 19.6 0.4 0.0012 18.3 0.3 1.6 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 ESS65715.1 - 0.0036 17.0 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 FeoC PF09012.5 ESS65715.1 - 0.038 13.6 0.0 0.097 12.3 0.0 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator Prefoldin PF02996.12 ESS65717.1 - 2.3e-09 36.9 1.1 3.1e-09 36.5 0.0 1.8 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.1 ESS65717.1 - 1.6e-06 27.7 1.8 0.0013 18.4 0.0 2.3 2 0 0 2 2 2 2 Prefoldin subunit DUF1819 PF08849.6 ESS65717.1 - 0.18 11.2 0.2 0.18 11.2 0.1 2.1 2 0 0 2 2 2 0 Putative inner membrane protein (DUF1819) TPR_11 PF13414.1 ESS65718.1 - 1.4e-23 82.3 11.1 6.4e-11 41.7 0.1 4.4 4 0 0 4 4 4 3 TPR repeat TPR_2 PF07719.12 ESS65718.1 - 1.9e-13 49.2 9.8 0.039 13.8 0.4 5.9 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65718.1 - 4.1e-10 40.0 14.6 1.4e-07 32.0 0.9 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65718.1 - 2e-08 33.4 10.2 0.069 12.7 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat CS PF04969.11 ESS65718.1 - 1.6e-07 31.7 0.0 2.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 CS domain TPR_12 PF13424.1 ESS65718.1 - 1.4e-06 28.1 13.5 0.018 15.0 0.4 4.7 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS65718.1 - 5.7e-06 26.5 4.3 0.00054 20.2 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS65718.1 - 6.1e-05 23.3 16.0 0.24 12.1 0.1 5.9 4 2 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS65718.1 - 7.7e-05 22.2 9.1 0.17 11.7 0.1 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65718.1 - 0.00074 19.1 0.8 5 7.1 0.1 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS65718.1 - 0.0014 18.5 7.9 1.9 8.5 0.1 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS65718.1 - 0.0053 16.8 0.4 0.03 14.5 0.0 2.6 2 0 0 2 2 1 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESS65718.1 - 0.014 15.6 2.4 2.2 8.5 0.1 2.6 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Apc3 PF12895.2 ESS65718.1 - 0.017 15.2 8.9 1 9.5 0.1 4.0 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Mab-21 PF03281.9 ESS65718.1 - 0.068 12.2 0.1 0.18 10.9 0.1 1.6 2 0 0 2 2 2 0 Mab-21 protein TPR_9 PF13371.1 ESS65718.1 - 0.071 12.9 12.3 3.1 7.7 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS65718.1 - 0.22 12.0 3.3 15 6.2 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat GBP_C PF02841.9 ESS65718.1 - 3 6.9 9.3 7.9 5.5 6.5 1.6 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FYVE PF01363.16 ESS65719.1 - 2.1e-13 49.9 19.1 4.3e-13 48.9 13.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger CTP_transf_1 PF01148.15 ESS65720.1 - 4.3e-32 111.8 17.8 2.2e-31 109.4 12.3 2.0 1 1 0 1 1 1 1 Cytidylyltransferase family Auto_anti-p27 PF06677.7 ESS65721.1 - 1.2 8.9 4.9 11 5.8 0.2 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) SNAP PF14938.1 ESS65722.1 - 1e-50 172.5 20.0 1.2e-50 172.3 13.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ESS65722.1 - 0.0012 18.7 11.6 0.11 12.4 3.8 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS65722.1 - 0.0019 18.2 8.7 0.029 14.4 2.8 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESS65722.1 - 0.0051 17.1 6.8 0.53 10.6 1.6 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat Foie-gras_1 PF11817.3 ESS65722.1 - 0.0052 16.3 5.5 0.01 15.3 3.8 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 TPR_14 PF13428.1 ESS65722.1 - 0.015 15.8 7.4 0.43 11.3 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS65722.1 - 0.047 13.4 14.1 3.8 7.5 0.1 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Imm12 PF15589.1 ESS65722.1 - 0.089 12.5 0.7 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 12 PPR_3 PF13812.1 ESS65722.1 - 0.19 12.0 3.2 16 6.0 0.0 3.7 3 0 0 3 3 3 0 Pentatricopeptide repeat domain TPR_2 PF07719.12 ESS65722.1 - 0.25 11.3 23.1 0.83 9.7 0.3 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS65722.1 - 0.25 11.8 0.3 0.25 11.8 0.2 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS65722.1 - 0.28 11.9 10.4 6.8 7.4 0.4 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS65722.1 - 2.3 8.2 14.5 0.57 10.1 0.6 4.6 4 2 1 5 5 5 0 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.2 ESS65722.1 - 6.1 5.3 10.9 3.1 6.3 0.5 2.7 1 1 1 2 2 2 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Reo_sigmaC PF04582.7 ESS65723.1 - 0.028 13.5 1.8 2 7.5 0.1 2.7 3 0 0 3 3 3 0 Reovirus sigma C capsid protein DUF948 PF06103.6 ESS65723.1 - 0.069 13.0 4.6 1 9.2 0.2 3.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Shufflon_N PF04917.7 ESS65723.1 - 0.24 10.4 0.0 0.39 9.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region UCH PF00443.24 ESS65724.1 - 1.7e-52 178.1 0.0 3e-52 177.4 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS65724.1 - 6.6e-18 65.1 0.3 1.6e-11 44.2 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PQQ_2 PF13360.1 ESS65725.1 - 0.00065 19.2 0.1 0.19 11.1 0.0 3.1 3 1 1 4 4 4 2 PQQ-like domain FG-GAP PF01839.18 ESS65725.1 - 0.0011 18.6 1.9 0.015 14.9 0.4 2.6 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.1 ESS65725.1 - 0.0052 17.1 0.0 0.3 11.4 0.0 2.9 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BBS2_C PF14782.1 ESS65725.1 - 0.21 10.1 0.0 0.32 9.5 0.0 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF1738 PF08401.6 ESS65726.1 - 5.4e-09 35.8 0.0 0.0012 18.5 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF1738) MCM PF00493.18 ESS65727.1 - 3e-101 338.5 0.0 4.3e-101 338.0 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESS65727.1 - 1.4e-14 54.5 0.0 2.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.9 ESS65727.1 - 4.3e-07 29.7 0.0 1.6e-06 27.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS65727.1 - 2.7e-05 23.4 0.0 0.0013 17.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESS65727.1 - 0.067 12.7 0.0 0.18 11.4 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS65727.1 - 0.5 10.3 3.7 7.8 6.4 0.0 3.4 2 2 0 2 2 2 0 AAA ATPase domain cNMP_binding PF00027.24 ESS65729.1 - 3.2e-25 87.7 0.1 1.2e-12 47.4 0.0 4.2 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain RINGv PF12906.2 ESS65731.1 - 2.7e-11 43.3 9.4 2.7e-11 43.3 6.5 2.9 3 0 0 3 3 3 1 RING-variant domain PIN_4 PF13638.1 ESS65732.1 - 4.6e-07 30.0 0.0 1.3e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 PIN domain PPR PF01535.15 ESS65732.1 - 0.02 14.8 0.0 10 6.3 0.0 3.3 3 0 0 3 3 3 0 PPR repeat Cnd3 PF12719.2 ESS65732.1 - 0.022 13.7 0.1 0.037 13.0 0.1 1.3 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain DUF3537 PF12056.3 ESS65732.1 - 0.025 13.2 0.0 0.039 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) HECT PF00632.20 ESS65733.1 - 1e-41 143.1 0.1 2.3e-41 142.0 0.1 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESS65733.1 - 7.6e-27 93.8 0.2 1.2e-09 38.2 0.0 4.5 4 0 0 4 4 4 4 SPRY domain ZZ PF00569.12 ESS65733.1 - 0.0094 15.4 11.2 0.033 13.7 7.8 1.9 1 0 0 1 1 1 1 Zinc finger, ZZ type HTH_Tnp_Tc3_1 PF11427.3 ESS65733.1 - 0.055 13.1 0.5 2.4 7.8 0.1 2.7 2 0 0 2 2 2 0 Tc3 transposase ResIII PF04851.10 ESS65734.1 - 4.9e-16 59.0 0.0 8.1e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESS65734.1 - 4.6e-11 42.4 0.0 9.7e-11 41.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESS65734.1 - 1.9e-09 36.7 0.0 3.1e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C_3 PF13625.1 ESS65734.1 - 5.9e-09 35.7 0.0 2e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS65734.1 - 6e-05 22.6 0.0 0.00049 19.6 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Peptidase_C54 PF03416.14 ESS65735.1 - 3e-52 177.5 0.0 4.5e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 Myosin_head PF00063.16 ESS65737.1 - 1.3e-169 565.5 3.1 3.2e-169 564.2 1.0 2.2 2 1 0 2 2 2 1 Myosin head (motor domain) UBA PF00627.26 ESS65737.1 - 5.3e-12 45.1 0.0 0.00024 20.8 0.0 3.6 3 0 0 3 3 3 2 UBA/TS-N domain CUE PF02845.11 ESS65737.1 - 0.0049 16.3 0.0 1.7 8.2 0.0 3.3 3 0 0 3 3 3 1 CUE domain SMC_N PF02463.14 ESS65737.1 - 0.011 14.9 0.2 0.026 13.7 0.0 1.7 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Antimicrobial15 PF08110.7 ESS65737.1 - 0.092 12.7 1.1 0.5 10.4 0.2 2.3 2 0 0 2 2 2 0 Ocellatin family Flu_C_NS2 PF03555.9 ESS65737.1 - 0.23 11.3 1.5 9 6.3 0.0 2.5 2 0 0 2 2 2 0 Influenza C non-structural protein (NS2) Synaphin PF05835.7 ESS65737.1 - 2.2 8.4 8.1 0.49 10.5 3.1 1.8 2 0 0 2 2 2 0 Synaphin protein RHSP PF07999.6 ESS65739.1 - 3e-108 362.2 0.3 4.2e-108 361.7 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS65739.1 - 0.011 15.8 0.1 4.5 7.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain DGF-1_5 PF11038.3 ESS65740.1 - 4.1e-130 432.9 22.8 4.1e-130 432.9 15.8 1.6 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS65740.1 - 5.1e-50 167.2 1.4 9.5e-50 166.4 0.9 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus HEV_ORF1 PF02444.11 ESS65740.1 - 1.8 8.7 9.5 1.1 9.4 1.2 3.6 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) TPT PF03151.11 ESS65741.1 - 4.1e-06 26.5 10.0 4.1e-06 26.5 6.9 2.5 2 1 1 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 ESS65741.1 - 0.67 9.9 30.8 0.045 13.7 3.3 3.1 3 0 0 3 3 3 0 EamA-like transporter family RPT PF13446.1 ESS65742.1 - 0.0019 17.5 0.1 1.2 8.6 0.0 3.8 3 0 0 3 3 3 1 A repeated domain in UCH-protein Seryl_tRNA_N PF02403.17 ESS65742.1 - 0.011 15.7 5.4 0.011 15.7 3.7 8.8 2 2 7 10 10 10 0 Seryl-tRNA synthetase N-terminal domain YojJ PF10372.4 ESS65742.1 - 0.064 13.1 0.4 0.064 13.1 0.3 4.9 5 0 0 5 5 5 0 Bacterial membrane-spanning protein N-terminus Cytochrome-c551 PF10643.4 ESS65742.1 - 0.2 10.9 6.1 3.8 6.7 0.1 2.6 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 TPT PF03151.11 ESS65743.1 - 1.2e-08 34.8 9.4 1.2e-08 34.8 6.5 2.8 1 1 1 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESS65743.1 - 4.1e-06 26.8 26.5 8.3e-05 22.6 5.9 2.5 2 1 0 2 2 2 2 EamA-like transporter family PDR_assoc PF08370.6 ESS65743.1 - 1.3 8.5 6.1 0.24 10.9 0.7 2.5 2 0 0 2 2 2 0 Plant PDR ABC transporter associated LRR_6 PF13516.1 ESS65744.1 - 5.6e-15 53.6 0.8 0.047 13.7 0.1 6.9 7 0 0 7 7 7 4 Leucine Rich repeat Peripla_BP_3 PF13377.1 ESS65744.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein-like domain Laminin_G_3 PF13385.1 ESS65745.1 - 9.3e-05 22.7 0.0 0.018 15.2 0.0 2.3 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 ESS65745.1 - 0.017 15.1 0.0 0.21 11.6 0.0 2.3 2 0 0 2 2 2 0 Laminin G domain Tet_JBP PF12851.2 ESS65746.1 - 1.3e-28 99.3 0.0 2.1e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily Rhodanese PF00581.15 ESS65747.1 - 3.3e-13 49.9 0.0 4.4e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain DnaJ PF00226.26 ESS65748.1 - 5.3e-13 48.5 0.0 9.9e-13 47.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain SET PF00856.23 ESS65750.1 - 1.8e-13 51.1 0.0 8.8e-12 45.6 0.0 2.5 1 1 0 1 1 1 1 SET domain SET PF00856.23 ESS65751.1 - 4.1e-11 43.4 0.0 1.2e-10 41.9 0.0 1.8 1 0 0 1 1 1 1 SET domain MFS_1 PF07690.11 ESS65752.1 - 0.00089 18.0 0.2 0.00089 18.0 0.2 2.8 3 0 0 3 3 3 1 Major Facilitator Superfamily F-box-like PF12937.2 ESS65752.1 - 0.0023 17.6 0.6 0.0093 15.6 0.4 2.1 1 0 0 1 1 1 1 F-box-like FA_desaturase PF00487.19 ESS65754.1 - 0.11 11.9 2.0 0.12 11.8 1.4 1.1 1 0 0 1 1 1 0 Fatty acid desaturase Tmp39 PF10271.4 ESS65754.1 - 0.2 10.2 4.0 0.23 10.0 2.8 1.0 1 0 0 1 1 1 0 Putative transmembrane protein DUF4131 PF13567.1 ESS65754.1 - 0.29 10.5 7.6 0.38 10.1 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SCAMP PF04144.8 ESS65754.1 - 0.47 10.3 10.7 0.51 10.1 7.4 1.0 1 0 0 1 1 1 0 SCAMP family CoA_binding_3 PF13727.1 ESS65754.1 - 0.75 9.6 2.8 0.83 9.4 1.9 1.0 1 0 0 1 1 1 0 CoA-binding domain ABC2_membrane_3 PF12698.2 ESS65754.1 - 2.4 7.0 6.2 3 6.8 4.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein OSTbeta PF15048.1 ESS65755.1 - 0.0056 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein CcmH PF03918.9 ESS65755.1 - 0.05 12.6 0.1 0.09 11.7 0.1 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein DGF-1_C PF11040.3 ESS65756.1 - 0.026 14.4 0.1 0.089 12.6 0.1 1.9 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Adeno_E3_CR2 PF02439.10 ESS65758.1 - 0.0025 17.3 2.5 0.0051 16.3 1.7 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Pput2613-deam PF14427.1 ESS65758.1 - 0.038 13.6 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 Pput_2613-like deaminase Flagellar_rod PF05149.7 ESS65759.1 - 1.3e-100 336.3 18.7 1.3e-100 336.3 13.0 2.3 2 0 0 2 2 2 2 Paraflagellar rod protein FlaC_arch PF05377.6 ESS65759.1 - 0.026 14.4 6.1 0.16 11.8 0.2 4.2 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Peptidase_C97 PF05903.9 ESS65763.1 - 8.5e-26 90.5 0.1 2.8e-25 88.8 0.0 1.7 2 0 0 2 2 2 1 PPPDE putative peptidase domain DUF4105 PF13387.1 ESS65763.1 - 0.097 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) LRAT PF04970.8 ESS65763.1 - 0.14 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Kelch_1 PF01344.20 ESS65764.1 - 0.036 13.6 0.0 0.089 12.3 0.0 1.6 1 1 0 1 1 1 0 Kelch motif Kelch_3 PF13415.1 ESS65765.1 - 7.6e-18 64.1 0.6 1.8e-05 24.7 0.0 4.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 ESS65765.1 - 2e-16 59.5 5.1 5.2e-05 22.9 0.0 5.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESS65765.1 - 2.7e-12 46.2 1.4 0.025 14.7 0.0 5.2 4 1 1 5 5 5 4 Kelch motif Kelch_5 PF13854.1 ESS65765.1 - 1.6e-10 40.7 9.8 1.6e-05 24.7 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESS65765.1 - 3.1e-08 33.0 6.8 0.07 12.6 0.0 4.4 4 1 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 ESS65765.1 - 6.3e-07 28.9 0.3 0.26 11.1 0.0 4.5 4 1 0 4 4 4 2 Kelch motif DUF3716 PF12511.3 ESS65766.1 - 0.083 12.5 1.6 0.93 9.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3716) Ribosomal_L44 PF00935.14 ESS65766.1 - 0.11 12.5 6.1 0.11 12.5 0.3 3.5 4 1 0 4 4 4 0 Ribosomal protein L44 DZR PF12773.2 ESS65766.1 - 0.13 12.0 5.6 0.51 10.2 0.1 3.3 2 2 1 3 3 3 0 Double zinc ribbon zf-DNL PF05180.7 ESS65766.1 - 0.18 11.5 3.1 5.4 6.8 0.1 3.3 4 0 0 4 4 4 0 DNL zinc finger Mu-like_Com PF10122.4 ESS65766.1 - 0.41 9.7 4.3 12 5.0 0.0 3.7 4 0 0 4 4 4 0 Mu-like prophage protein Com Auto_anti-p27 PF06677.7 ESS65766.1 - 1.7 8.4 7.1 2.7 7.8 0.2 3.5 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zinc_ribbon_2 PF13240.1 ESS65766.1 - 7.9 6.1 7.6 9.5 5.8 0.2 3.7 4 0 0 4 4 4 0 zinc-ribbon domain Mito_carr PF00153.22 ESS65767.1 - 2.4e-46 155.3 3.0 3.5e-15 55.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C97 PF05903.9 ESS65769.1 - 2.6e-21 75.9 0.0 4.1e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Armet PF10208.4 ESS65769.1 - 0.0007 19.2 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding Bromodomain PF00439.20 ESS65772.1 - 2e-17 62.8 0.0 2.8e-09 36.7 0.0 2.5 2 0 0 2 2 2 2 Bromodomain BSD PF03909.12 ESS65772.1 - 0.14 11.9 1.2 0.75 9.5 0.1 2.5 3 0 0 3 3 3 0 BSD domain AAA_11 PF13086.1 ESS65774.1 - 9.7e-20 71.1 0.1 5.2e-18 65.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS65774.1 - 2.6e-11 43.1 0.1 8e-11 41.5 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain UvrD-helicase PF00580.16 ESS65774.1 - 0.0012 18.2 0.0 0.0063 15.8 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_30 PF13604.1 ESS65774.1 - 0.0013 18.2 0.0 0.004 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 ESS65774.1 - 0.0031 17.3 0.0 0.0065 16.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESS65774.1 - 0.0072 16.4 0.0 0.036 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESS65774.1 - 0.0081 16.1 0.8 0.063 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain ParA PF10609.4 ESS65774.1 - 0.042 13.7 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 ParA/MinD ATPase like Helicase_RecD PF05127.9 ESS65774.1 - 0.11 12.0 0.9 0.25 10.9 0.0 2.0 3 0 0 3 3 3 0 Helicase AAA_23 PF13476.1 ESS65774.1 - 0.52 10.6 0.0 0.52 10.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_12 PF13087.1 ESS65775.1 - 6.6e-42 143.1 0.0 9.2e-42 142.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 ESS65775.1 - 0.078 13.1 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain zf-CCHC_4 PF14392.1 ESS65776.1 - 0.018 14.7 0.8 0.018 14.7 0.6 2.0 2 0 0 2 2 2 0 Zinc knuckle AAA PF00004.24 ESS65777.1 - 2.4e-30 105.4 0.1 1e-18 67.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS65777.1 - 7.7e-11 42.2 0.1 0.00016 21.7 0.0 4.2 3 1 1 4 4 3 2 AAA domain Zot PF05707.7 ESS65777.1 - 7.3e-10 38.6 0.8 4.3e-05 23.0 0.1 4.0 3 1 0 3 3 3 2 Zonular occludens toxin (Zot) AAA_16 PF13191.1 ESS65777.1 - 2.7e-08 33.9 0.1 0.00029 20.8 0.0 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_14 PF13173.1 ESS65777.1 - 4.3e-07 29.8 0.0 4.2e-05 23.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS65777.1 - 1.2e-06 28.2 1.2 0.0061 16.2 0.1 3.4 3 0 0 3 3 3 2 Part of AAA domain RNA_helicase PF00910.17 ESS65777.1 - 3.3e-06 27.2 0.0 0.016 15.3 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.1 ESS65777.1 - 1e-05 25.0 0.1 0.12 11.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 ESS65777.1 - 1.2e-05 25.2 0.0 0.11 12.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 ESS65777.1 - 1.4e-05 24.5 0.1 0.015 14.6 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.1 ESS65777.1 - 5.3e-05 23.5 0.0 0.00093 19.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESS65777.1 - 8.4e-05 22.3 0.1 0.15 11.7 0.0 3.0 2 1 0 2 2 2 1 Archaeal ATPase AAA_10 PF12846.2 ESS65777.1 - 0.00011 21.7 2.7 0.26 10.6 0.1 4.0 2 2 2 4 4 4 1 AAA-like domain AAA_17 PF13207.1 ESS65777.1 - 0.00014 22.6 0.0 0.047 14.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 ESS65777.1 - 0.00016 21.9 0.0 0.32 11.2 0.0 3.4 3 0 0 3 3 2 1 ABC transporter AAA_5 PF07728.9 ESS65777.1 - 0.0004 20.1 0.1 0.052 13.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 ESS65777.1 - 0.0007 19.9 0.9 0.18 12.0 0.1 3.1 3 1 0 3 3 2 1 AAA domain TIP49 PF06068.8 ESS65777.1 - 0.0011 17.8 0.0 0.016 13.9 0.0 2.4 2 0 0 2 2 2 1 TIP49 C-terminus PhoH PF02562.11 ESS65777.1 - 0.0012 18.1 0.1 0.067 12.4 0.0 3.1 3 1 0 3 3 3 1 PhoH-like protein Mg_chelatase PF01078.16 ESS65777.1 - 0.0015 17.7 1.0 0.066 12.3 0.1 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 ESS65777.1 - 0.0015 17.4 0.0 0.26 10.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_29 PF13555.1 ESS65777.1 - 0.0016 17.9 0.3 1.4 8.4 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.7 ESS65777.1 - 0.002 17.8 0.0 0.21 11.2 0.0 2.7 2 0 0 2 2 2 1 NACHT domain RuvB_N PF05496.7 ESS65777.1 - 0.0022 17.0 0.0 0.039 13.0 0.0 2.7 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus T2SE PF00437.15 ESS65777.1 - 0.0041 16.0 0.0 0.026 13.4 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF258 PF03193.11 ESS65777.1 - 0.0059 15.8 0.0 0.25 10.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 DUF2075 PF09848.4 ESS65777.1 - 0.007 15.3 0.1 2 7.2 0.0 3.3 2 1 1 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 ESS65777.1 - 0.0071 15.9 0.0 2 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESS65777.1 - 0.0088 15.9 0.0 0.12 12.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF2042 PF09743.4 ESS65777.1 - 0.0096 15.2 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) ResIII PF04851.10 ESS65777.1 - 0.011 15.5 0.1 0.87 9.3 0.1 2.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Torsin PF06309.6 ESS65777.1 - 0.013 15.3 0.1 2.4 8.0 0.0 3.1 2 0 0 2 2 2 0 Torsin Sigma54_activat PF00158.21 ESS65777.1 - 0.016 14.7 0.0 1.4 8.3 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain PEPCK_ATP PF01293.15 ESS65777.1 - 0.016 13.7 0.8 0.038 12.5 0.3 1.7 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase APS_kinase PF01583.15 ESS65777.1 - 0.061 12.9 0.1 0.17 11.4 0.0 1.8 2 0 0 2 2 1 0 Adenylylsulphate kinase AAA_28 PF13521.1 ESS65777.1 - 0.064 13.2 0.1 1.2 9.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 ESS65777.1 - 0.098 12.2 0.6 0.29 10.7 0.0 2.1 2 0 0 2 2 1 0 Bacterial dnaA protein AAA_24 PF13479.1 ESS65777.1 - 0.2 11.2 0.5 0.47 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Ank_2 PF12796.2 ESS65778.1 - 0.00027 21.2 0.9 13 6.2 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESS65778.1 - 0.0041 16.8 0.7 0.54 10.1 0.1 3.7 3 0 0 3 3 3 1 Ankyrin repeat Nucleoplasmin PF03066.10 ESS65779.1 - 0.025 14.1 2.7 0.038 13.5 1.9 1.4 1 0 0 1 1 1 0 Nucleoplasmin Nop14 PF04147.7 ESS65779.1 - 0.048 11.5 7.1 0.068 11.0 4.9 1.1 1 0 0 1 1 1 0 Nop14-like family Trypan_PARP PF05887.6 ESS65779.1 - 0.063 13.1 2.3 0.11 12.2 1.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.9 ESS65779.1 - 0.27 9.2 7.0 0.43 8.5 4.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 ESS65779.1 - 5.7 5.2 11.5 0.86 8.0 5.5 1.3 2 0 0 2 2 2 0 Daxx Family DUF2722 PF10846.3 ESS65779.1 - 7.5 5.4 6.5 0.53 9.2 1.2 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SAPS PF04499.10 ESS65782.1 - 0.035 12.7 5.2 0.057 12.0 0.5 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Dicer_dimer PF03368.9 ESS65782.1 - 0.12 12.1 0.1 0.4 10.4 0.0 1.8 2 0 0 2 2 2 0 Dicer dimerisation domain IncA PF04156.9 ESS65783.1 - 0.29 10.7 1.5 0.34 10.4 0.1 1.7 2 0 0 2 2 2 0 IncA protein DUF4201 PF13870.1 ESS65785.1 - 0.00017 21.0 6.4 0.00017 21.0 4.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) CorA PF01544.13 ESS65785.1 - 0.0041 16.2 3.3 0.33 9.9 0.0 2.5 1 1 0 2 2 2 1 CorA-like Mg2+ transporter protein E2R135 PF11570.3 ESS65785.1 - 0.0063 16.6 5.1 5.2 7.1 0.0 3.6 4 0 0 4 4 3 0 Coiled-coil receptor-binding R-domain of colicin E2 ADIP PF11559.3 ESS65785.1 - 0.014 15.2 5.3 0.032 14.1 2.5 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 ESS65785.1 - 0.027 14.0 9.9 0.084 12.4 7.0 1.7 1 1 0 1 1 1 0 IncA protein TBPIP PF07106.8 ESS65785.1 - 0.028 13.9 5.0 0.067 12.7 3.4 1.6 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIVA PF05103.8 ESS65785.1 - 0.038 14.0 4.7 0.19 11.7 2.5 2.3 2 0 0 2 2 2 0 DivIVA protein SCP-1 PF05483.7 ESS65785.1 - 0.058 11.1 7.7 0.059 11.1 0.2 2.2 1 1 1 2 2 2 0 Synaptonemal complex protein 1 (SCP-1) IFT57 PF10498.4 ESS65785.1 - 0.082 11.6 3.1 0.14 10.8 2.2 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Mnd1 PF03962.10 ESS65785.1 - 0.089 12.4 5.6 0.073 12.7 2.8 1.8 2 0 0 2 2 1 0 Mnd1 family Laminin_I PF06008.9 ESS65785.1 - 0.089 12.0 8.9 0.12 11.6 5.0 2.1 2 1 0 2 2 2 0 Laminin Domain I Syntaxin_2 PF14523.1 ESS65785.1 - 0.11 12.5 2.7 0.21 11.6 0.8 2.2 2 1 0 2 2 1 0 Syntaxin-like protein DUF948 PF06103.6 ESS65785.1 - 0.13 12.1 3.2 4.1 7.3 0.3 3.0 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) APG6 PF04111.7 ESS65785.1 - 0.24 10.3 5.6 0.24 10.4 2.9 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.7 ESS65785.1 - 0.25 11.0 9.8 5.5 6.7 6.2 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 ESS65785.1 - 0.35 9.7 5.0 1.4 7.7 3.6 1.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Snapin_Pallidin PF14712.1 ESS65785.1 - 0.51 10.6 3.9 0.71 10.2 0.4 2.5 1 1 1 2 2 2 0 Snapin/Pallidin Syntaxin PF00804.20 ESS65785.1 - 0.54 10.4 8.3 0.46 10.6 3.3 2.5 1 1 1 2 2 2 0 Syntaxin YopD PF05844.7 ESS65785.1 - 0.56 9.1 6.2 0.071 12.1 0.8 1.8 2 0 0 2 2 2 0 YopD protein TMCO5 PF14992.1 ESS65785.1 - 0.58 9.2 8.0 1.1 8.3 5.6 1.4 1 1 0 1 1 1 0 TMCO5 family AAA_13 PF13166.1 ESS65785.1 - 0.79 8.1 7.0 0.47 8.8 3.7 1.5 1 1 0 1 1 1 0 AAA domain ATG16 PF08614.6 ESS65785.1 - 0.91 9.3 9.3 0.24 11.2 2.1 2.4 2 1 1 3 3 2 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.16 ESS65785.1 - 1.2 9.1 11.0 0.62 10.0 0.3 3.4 2 1 1 3 3 3 0 bZIP transcription factor OmpH PF03938.9 ESS65785.1 - 1.4 8.8 5.7 1.7 8.5 3.2 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Rootletin PF15035.1 ESS65785.1 - 1.5 8.7 10.1 3 7.7 1.1 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF641 PF04859.7 ESS65785.1 - 1.6 8.4 7.0 0.42 10.3 0.6 2.7 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) Spc7 PF08317.6 ESS65785.1 - 1.8 7.1 8.5 0.16 10.5 2.2 1.9 2 1 0 2 2 2 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.3 ESS65785.1 - 2.5 7.8 11.4 0.35 10.6 3.9 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Laminin_II PF06009.7 ESS65785.1 - 2.9 7.6 7.2 0.8 9.4 1.6 2.5 2 1 2 4 4 3 0 Laminin Domain II COG2 PF06148.6 ESS65785.1 - 4.6 7.1 6.9 6 6.7 1.2 3.0 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Tropomyosin_1 PF12718.2 ESS65785.1 - 5.1 6.9 11.8 2.1 8.1 4.4 2.7 3 0 0 3 3 3 0 Tropomyosin like CENP-Q PF13094.1 ESS65785.1 - 5.9 6.9 10.4 32 4.4 7.2 2.2 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.7 ESS65785.1 - 6 7.3 6.2 7.7 6.9 0.8 3.1 2 1 0 3 3 3 0 SlyX Seryl_tRNA_N PF02403.17 ESS65785.1 - 6.3 6.8 10.0 0.36 10.8 0.9 2.7 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.1 ESS65785.1 - 7.7 5.6 11.5 0.86 8.7 4.5 1.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding HALZ PF02183.13 ESS65785.1 - 9.5 6.0 9.6 1.2 8.9 0.8 3.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper GTP_EFTU PF00009.22 ESS65786.1 - 3e-34 118.0 0.0 6.8e-34 116.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 ESS65786.1 - 5.1e-29 100.1 0.2 1.3e-28 98.8 0.1 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 ESS65786.1 - 1.5e-05 25.0 0.8 0.00012 22.0 0.2 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESS65786.1 - 0.00033 20.5 0.0 0.00082 19.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Zn-ribbon_8 PF09723.5 ESS65786.1 - 0.00039 20.3 0.8 0.00097 19.0 0.6 1.7 1 0 0 1 1 1 1 Zinc ribbon domain Arf PF00025.16 ESS65786.1 - 0.043 13.0 0.1 0.28 10.4 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Dynamin_N PF00350.18 ESS65786.1 - 0.078 12.7 0.1 0.43 10.3 0.0 2.2 2 0 0 2 2 2 0 Dynamin family zf-C4_Topoisom PF01396.14 ESS65786.1 - 0.091 12.2 0.3 0.091 12.2 0.2 2.0 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger DZR PF12773.2 ESS65786.1 - 0.86 9.4 3.8 0.72 9.7 1.2 1.9 2 0 0 2 2 2 0 Double zinc ribbon RNA_pol_Rbc25 PF08292.7 ESS65787.1 - 2.2e-28 98.8 0.0 3.8e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 ESS65787.1 - 3.9e-26 90.9 0.0 6.4e-26 90.2 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LCAT PF02450.10 ESS65789.1 - 4.2e-50 170.8 0.0 1.8e-48 165.4 0.0 2.1 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 ESS65789.1 - 0.0074 16.1 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS65789.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family CDC50 PF03381.10 ESS65790.1 - 1e-58 198.7 0.0 1e-58 198.7 0.0 1.4 2 0 0 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Cupin_2 PF07883.6 ESS65790.1 - 0.12 11.8 0.0 0.34 10.4 0.0 1.7 1 0 0 1 1 1 0 Cupin domain Motile_Sperm PF00635.21 ESS65792.1 - 1.6e-14 53.4 0.3 3.4e-14 52.3 0.2 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Rhodanese PF00581.15 ESS65793.1 - 1e-13 51.6 0.0 1.3e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Pico_P2A PF00947.14 ESS65793.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Picornavirus core protein 2A Skp1 PF01466.14 ESS65794.1 - 0.00016 21.6 1.2 0.00076 19.4 0.8 1.9 1 1 0 1 1 1 1 Skp1 family, dimerisation domain NeuB PF03102.9 ESS65795.1 - 0.023 13.8 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 NeuB family DUF4157 PF13699.1 ESS65795.1 - 0.046 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) SSXT PF05030.7 ESS65796.1 - 0.17 11.4 1.1 0.24 10.9 0.1 1.6 2 0 0 2 2 2 0 SSXT protein (N-terminal region) DivIVA PF05103.8 ESS65796.1 - 0.26 11.3 1.4 7.3 6.6 0.1 2.2 2 0 0 2 2 2 0 DivIVA protein Coq4 PF05019.8 ESS65797.1 - 2.6e-79 265.2 0.0 3.3e-79 264.9 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 TF_Zn_Ribbon PF08271.7 ESS65797.1 - 0.0019 17.5 0.1 0.003 16.8 0.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding DUF4331 PF14224.1 ESS65797.1 - 0.04 13.0 0.0 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4331) DUF1289 PF06945.8 ESS65797.1 - 0.048 13.1 0.1 0.11 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) DUF581 PF04570.9 ESS65797.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF581) Rhodanese PF00581.15 ESS65798.1 - 4.2e-13 49.6 0.0 5e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Tim17 PF02466.14 ESS65799.1 - 2e-17 63.3 8.6 2.6e-17 63.0 6.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MRP PF09387.5 ESS65800.1 - 1e-69 234.1 0.3 1.2e-69 233.9 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP EF-hand_7 PF13499.1 ESS65801.1 - 4.5e-06 26.6 1.8 0.0017 18.4 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS65801.1 - 0.00016 21.2 3.5 0.83 9.7 0.1 4.2 3 2 0 3 3 3 2 EF-hand domain RIIa PF02197.12 ESS65801.1 - 0.0012 18.1 0.0 0.0024 17.2 0.0 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_1 PF00036.27 ESS65801.1 - 0.0071 15.5 7.2 0.12 11.7 0.1 3.8 3 1 1 4 4 4 2 EF hand EF-hand_5 PF13202.1 ESS65801.1 - 0.68 9.3 8.3 3.1 7.3 0.2 3.2 3 0 0 3 3 3 0 EF hand zf-AN1 PF01428.11 ESS65803.1 - 0.68 9.8 4.3 9.1 6.2 0.9 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger Cyt-b5 PF00173.23 ESS65804.1 - 5.3e-22 77.4 0.4 6.6e-22 77.0 0.3 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rhodanese PF00581.15 ESS65812.1 - 6.1e-07 29.7 0.0 1.3e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_18 PF12847.2 ESS65812.1 - 7.2e-07 29.7 0.0 1.5e-06 28.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS65812.1 - 0.00074 19.2 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS65812.1 - 0.00095 18.7 0.0 0.0028 17.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS65812.1 - 0.0018 18.7 0.0 0.0033 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESS65812.1 - 0.0022 17.1 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 ESS65812.1 - 0.026 13.5 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_15 PF09445.5 ESS65812.1 - 0.028 13.9 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.1 ESS65812.1 - 0.052 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.6 ESS65812.1 - 0.072 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) LRR_4 PF12799.2 ESS65813.1 - 2.4e-22 78.1 23.4 0.031 13.9 0.0 10.6 7 5 2 11 11 11 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65813.1 - 4.9e-16 58.2 15.1 0.0087 15.8 0.0 8.0 5 3 3 9 9 9 6 Leucine rich repeat LRR_6 PF13516.1 ESS65813.1 - 6.4e-13 47.3 25.7 0.21 11.7 0.1 12.3 12 2 1 14 14 14 5 Leucine Rich repeat LRR_1 PF00560.28 ESS65813.1 - 8.5e-08 31.2 29.8 5.8 7.3 0.0 13.6 14 4 0 14 14 14 2 Leucine Rich Repeat LRR_5 PF13306.1 ESS65813.1 - 0.00095 18.8 7.5 15 5.3 0.1 5.7 5 2 0 5 5 5 2 Leucine rich repeats (6 copies) DUF2408 PF10303.4 ESS65813.1 - 2.6 8.1 5.1 27 4.8 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2408) Actin PF00022.14 ESS65814.1 - 3.2e-149 496.6 0.0 3.8e-149 496.4 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ESS65814.1 - 0.0072 16.7 0.0 0.14 12.5 0.0 2.2 1 1 1 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) LRR_6 PF13516.1 ESS65816.1 - 1.9e-07 30.4 0.3 0.4 10.8 1.1 3.7 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.28 ESS65816.1 - 0.0013 18.4 0.9 13 6.3 0.0 4.3 4 1 0 4 4 4 1 Leucine Rich Repeat LRR_4 PF12799.2 ESS65816.1 - 0.0014 18.1 0.5 0.073 12.7 0.4 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS65816.1 - 0.1 12.3 0.2 3.3 7.5 0.2 2.5 1 1 1 2 2 2 0 Leucine rich repeat PolyA_pol PF01743.15 ESS65817.1 - 9.3e-27 93.7 0.0 1.5e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 ESS65817.1 - 8.7e-08 31.6 0.2 2.6e-07 30.0 0.1 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A RRM_5 PF13893.1 ESS65819.1 - 7.6e-22 76.9 0.5 2.3e-10 40.1 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS65819.1 - 1.8e-13 49.9 0.0 9.7e-06 25.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS65819.1 - 2.4e-13 49.8 0.1 4.6e-08 32.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CDC48_2 PF02933.12 ESS65819.1 - 0.0028 17.2 0.0 0.0052 16.4 0.0 1.4 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Calcipressin PF04847.7 ESS65819.1 - 0.0038 16.8 0.7 0.035 13.6 0.2 2.1 2 0 0 2 2 2 1 Calcipressin DUF3588 PF12140.3 ESS65819.1 - 0.049 13.7 0.6 0.12 12.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3588) DUF1411 PF07199.6 ESS65819.1 - 0.71 9.2 3.6 3 7.2 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1411) FBPase PF00316.15 ESS65820.1 - 1.5e-108 362.4 0.0 1.7e-108 362.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase DnaB_bind PF10410.4 ESS65820.1 - 0.1 12.5 0.1 1 9.3 0.0 2.2 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase Inositol_P PF00459.20 ESS65820.1 - 0.11 11.7 0.0 2.2 7.5 0.0 2.6 2 1 1 3 3 3 0 Inositol monophosphatase family Flg_bb_rod PF00460.15 ESS65820.1 - 0.54 10.0 3.2 0.23 11.1 0.3 1.9 2 0 0 2 2 2 0 Flagella basal body rod protein SCO1-SenC PF02630.9 ESS65822.1 - 1.8e-41 141.6 0.0 2.4e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 ESS65822.1 - 0.0029 17.3 0.0 0.006 16.2 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family E1-E2_ATPase PF00122.15 ESS65824.1 - 1.1e-54 184.9 1.8 1.3e-52 178.0 1.9 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 ESS65824.1 - 6.5e-24 85.5 0.0 2.6e-23 83.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS65824.1 - 3.1e-15 56.8 0.0 5.9e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESS65824.1 - 6.4e-11 41.5 0.0 1.8e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESS65824.1 - 3.1e-05 23.6 0.1 0.0009 18.8 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ion_trans_2 PF07885.11 ESS65824.1 - 0.028 14.1 3.4 0.028 14.1 0.0 2.7 3 0 0 3 3 3 0 Ion channel Ank_2 PF12796.2 ESS65825.1 - 7.1e-55 183.3 0.1 1.5e-21 76.5 0.0 3.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 ESS65825.1 - 2.3e-32 109.1 4.3 2e-08 33.6 0.1 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.1 ESS65825.1 - 3.9e-27 91.5 0.0 6.8e-05 22.7 0.0 5.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.1 ESS65825.1 - 4.4e-26 90.7 0.0 1.7e-10 41.1 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESS65825.1 - 1.1e-20 73.1 1.2 7.4e-06 26.0 0.1 5.0 1 1 4 5 5 5 4 Ankyrin repeats (many copies) DUF3582 PF12122.3 ESS65825.1 - 0.086 12.8 0.0 0.2 11.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3582) Tcf25 PF04910.9 ESS65827.1 - 4.6e-47 160.6 0.3 9e-47 159.7 0.0 1.6 2 0 0 2 2 2 1 Transcriptional repressor TCF25 DUF3437 PF11919.3 ESS65827.1 - 0.14 11.8 1.3 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Tcf25 PF04910.9 ESS65828.1 - 5.5e-14 51.8 0.0 7.3e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 DUF761 PF05553.6 ESS65828.1 - 0.033 13.5 0.1 0.078 12.3 0.1 1.7 1 0 0 1 1 1 0 Cotton fibre expressed protein DUF947 PF06102.7 ESS65829.1 - 2.9e-15 56.4 11.3 7.7e-15 55.1 7.9 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF947) Voltage_CLC PF00654.15 ESS65830.1 - 1.8e-91 306.7 27.8 1.8e-91 306.7 19.3 1.8 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 ESS65830.1 - 2.3e-10 40.0 3.5 3.3e-05 23.5 0.1 3.5 2 1 0 2 2 2 2 CBS domain TAT_signal PF10518.4 ESS65830.1 - 0.011 15.7 0.1 0.011 15.7 0.1 3.4 4 0 0 4 4 4 0 TAT (twin-arginine translocation) pathway signal sequence Daxx PF03344.10 ESS65831.1 - 0.00027 19.6 22.2 0.00031 19.4 15.4 1.1 1 0 0 1 1 1 1 Daxx Family BUD22 PF09073.5 ESS65831.1 - 0.0029 16.7 20.0 0.0036 16.4 13.9 1.1 1 0 0 1 1 1 1 BUD22 CobT PF06213.7 ESS65831.1 - 0.0063 15.6 22.9 0.0091 15.1 15.9 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 ESS65831.1 - 0.011 13.6 25.2 0.015 13.2 17.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2201_N PF13203.1 ESS65831.1 - 0.042 13.0 7.3 0.056 12.6 5.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Phage_int_SAM_1 PF02899.12 ESS65831.1 - 0.068 13.3 0.4 0.48 10.6 0.0 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain CDC45 PF02724.9 ESS65831.1 - 0.075 11.0 21.9 0.12 10.3 15.2 1.3 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.7 ESS65831.1 - 0.09 12.0 27.9 0.13 11.5 19.3 1.2 1 0 0 1 1 1 0 SDA1 Spore_coat_CotO PF14153.1 ESS65831.1 - 0.12 11.7 6.7 0.16 11.4 4.6 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Vfa1 PF08432.5 ESS65831.1 - 0.19 11.7 10.2 0.35 10.8 7.1 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Prothymosin PF03247.9 ESS65831.1 - 0.25 11.5 43.4 0.47 10.6 30.1 1.4 1 0 0 1 1 1 0 Prothymosin/parathymosin family Ycf1 PF05758.7 ESS65831.1 - 0.29 8.7 4.9 0.34 8.5 3.4 1.1 1 0 0 1 1 1 0 Ycf1 FancD2 PF14631.1 ESS65831.1 - 0.48 7.4 2.9 0.64 7.0 2.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease SAPS PF04499.10 ESS65831.1 - 0.53 8.8 6.0 0.53 8.8 4.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pilt PF15453.1 ESS65831.1 - 1 8.9 7.8 1.4 8.4 5.4 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions DDHD PF02862.12 ESS65831.1 - 1.3 8.7 4.1 1.8 8.3 2.8 1.3 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.2 ESS65831.1 - 2.1 5.9 4.0 2.2 5.8 2.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1510 PF07423.6 ESS65831.1 - 2.6 7.3 23.3 3.9 6.7 16.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TFIIA PF03153.8 ESS65831.1 - 5.1 6.8 21.5 8.2 6.2 14.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VID27 PF08553.5 ESS65831.1 - 8.7 4.4 17.1 12 3.9 11.8 1.2 1 0 0 1 1 1 0 VID27 cytoplasmic protein Spc97_Spc98 PF04130.8 ESS65831.1 - 9.2 4.4 7.6 17 3.5 4.1 1.8 1 1 1 2 2 2 0 Spc97 / Spc98 family DZR PF12773.2 ESS65833.1 - 0.0061 16.3 2.3 0.22 11.3 1.6 2.6 1 1 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 ESS65833.1 - 0.011 14.8 5.3 0.13 11.5 0.4 2.9 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESS65833.1 - 0.015 14.7 6.2 0.77 9.3 0.2 2.9 2 0 0 2 2 2 0 zinc-ribbon domain DUF1178 PF06676.6 ESS65833.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) PAS_7 PF12860.2 ESS65834.1 - 0.056 13.4 0.3 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 PAS fold CTDII PF01556.13 ESS65835.1 - 6.6e-29 99.6 2.1 1e-21 76.6 0.1 3.3 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ PF00226.26 ESS65835.1 - 8.1e-24 83.1 0.8 1.4e-23 82.3 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESS65835.1 - 6.6e-09 35.6 23.6 1.3e-08 34.7 16.3 1.5 1 0 0 1 1 1 1 DnaJ central domain zf-RING_2 PF13639.1 ESS65836.1 - 1.2e-13 50.6 8.0 2.2e-13 49.7 5.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESS65836.1 - 7.6e-08 32.3 3.8 1.9e-07 31.1 2.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESS65836.1 - 2.4e-06 27.4 8.1 4.1e-06 26.7 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS65836.1 - 1.7e-05 24.4 4.6 2.8e-05 23.6 3.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS65836.1 - 0.00016 21.3 6.7 0.00026 20.6 4.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESS65836.1 - 0.00098 18.7 7.1 0.0017 17.9 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS65836.1 - 0.0013 18.5 3.4 0.0053 16.5 2.2 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ESS65836.1 - 0.0047 16.6 3.0 0.0047 16.6 2.0 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.1 ESS65836.1 - 0.026 14.1 5.0 0.062 12.8 3.6 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Cmc1 PF08583.5 ESS65837.1 - 0.00037 20.2 2.6 0.00065 19.4 1.8 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like SEN1_N PF12726.2 ESS65837.1 - 0.078 11.0 0.1 0.078 11.0 0.0 1.8 2 0 0 2 2 2 0 SEN1 N terminal Skp1_POZ PF03931.10 ESS65838.1 - 2.3e-05 24.4 0.1 0.00017 21.5 0.0 2.0 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain TPR_12 PF13424.1 ESS65839.1 - 6.5e-07 29.2 0.7 0.016 15.1 0.0 2.9 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS65839.1 - 0.00011 21.7 0.0 0.0031 17.3 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS65839.1 - 0.00013 21.4 0.1 0.022 14.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.4 ESS65839.1 - 0.0028 17.6 0.0 0.0063 16.4 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS65839.1 - 0.0033 16.9 0.0 0.028 14.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS65839.1 - 0.02 14.5 0.3 0.062 12.9 0.0 1.9 2 0 0 2 2 2 0 TPR repeat IQ PF00612.22 ESS65839.1 - 0.025 14.1 0.0 0.068 12.8 0.0 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Rhomboid PF01694.17 ESS65841.1 - 2.8e-06 27.4 4.0 5.6e-06 26.4 2.7 1.5 1 1 0 1 1 1 1 Rhomboid family Y_phosphatase2 PF03162.8 ESS65842.1 - 1.6e-48 164.2 0.0 2.5e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family GHL12 PF14882.1 ESS65843.1 - 0.15 12.2 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 12 Pep_deformylase PF01327.16 ESS65844.1 - 8.7e-32 109.6 0.0 1.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Polypeptide deformylase Pescadillo_N PF06732.6 ESS65845.1 - 1.5e-90 303.2 3.6 2.8e-90 302.3 2.5 1.4 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT PF00533.21 ESS65845.1 - 4.6e-09 36.3 0.0 1.5e-08 34.6 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Tmemb_185A PF10269.4 ESS65848.1 - 1.1e-58 198.7 15.4 1.8e-58 197.9 10.7 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein DnaJ PF00226.26 ESS65848.1 - 2.6e-20 71.8 0.0 4e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4551 PF15087.1 ESS65848.1 - 0.018 13.4 0.1 0.025 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) NAC PF01849.13 ESS65849.1 - 5.5e-16 57.8 0.0 1e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 NAC domain UBA PF00627.26 ESS65849.1 - 0.092 12.6 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 UBA/TS-N domain WASH_WAHD PF11945.3 ESS65850.1 - 2.5e-29 102.5 0.0 3.4e-16 59.3 0.0 2.2 2 0 0 2 2 2 2 WAHD domain of WASH complex PDZ_2 PF13180.1 ESS65852.1 - 3.5e-10 39.6 0.3 1.9e-08 34.0 0.1 2.8 2 0 0 2 2 2 1 PDZ domain CesT PF05932.8 ESS65852.1 - 9.1e-09 35.2 0.0 3.9e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Tir chaperone protein (CesT) family PDZ PF00595.19 ESS65852.1 - 0.0014 18.7 0.6 0.058 13.5 0.1 2.7 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_1 PF12812.2 ESS65852.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 PDZ-like domain MgtE PF01769.11 ESS65853.1 - 1 9.6 12.6 0.82 9.9 2.3 3.2 2 1 1 3 3 3 0 Divalent cation transporter Cyclin_N PF00134.18 ESS65854.1 - 0.032 13.7 0.4 0.063 12.8 0.2 1.6 1 1 0 1 1 1 0 Cyclin, N-terminal domain RVT_1 PF00078.22 ESS65856.1 - 3.2e-17 62.6 0.0 4.8e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Catalase PF00199.14 ESS65856.1 - 0.082 11.5 0.1 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Catalase Ribosomal_L30 PF00327.15 ESS65857.1 - 0.00043 19.8 0.0 0.00083 18.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e ICAP-1_inte_bdg PF10480.4 ESS65857.1 - 0.5 10.1 0.0 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Beta-1 integrin binding protein ADK PF00406.17 ESS65858.1 - 4.6e-38 130.4 0.0 5.5e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESS65858.1 - 4e-08 34.1 0.1 6.1e-08 33.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESS65858.1 - 8.5e-08 32.5 0.0 1.5e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS65858.1 - 3.2e-07 30.2 0.0 1.1e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESS65858.1 - 0.0062 15.6 0.0 0.0085 15.2 0.0 1.6 1 1 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.12 ESS65858.1 - 0.039 13.3 0.1 1.9 7.8 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase UQ_con PF00179.21 ESS65859.1 - 1e-44 151.3 0.0 1.1e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESS65859.1 - 8.4e-05 22.3 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESS65859.1 - 0.012 15.4 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.8 ESS65859.1 - 0.017 14.7 0.2 0.035 13.7 0.2 1.5 1 1 0 1 1 1 0 UEV domain LURAP PF14854.1 ESS65860.1 - 0.019 14.7 0.2 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 Leucine rich adaptor protein DUF1227 PF06777.6 ESS65860.1 - 0.028 14.1 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1227) CaM-KIIN PF15170.1 ESS65860.1 - 0.094 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Calcium/calmodulin-dependent protein kinase II inhibitor Orthopox_B11R PF07033.6 ESS65861.1 - 0.033 13.6 0.3 0.052 13.0 0.2 1.3 1 0 0 1 1 1 0 Orthopoxvirus B11R protein DUF974 PF06159.8 ESS65862.1 - 3.7e-11 42.9 0.0 1.1e-10 41.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF974) Transglut_C PF00927.17 ESS65862.1 - 0.00063 19.7 0.0 0.041 13.9 0.0 3.3 3 0 0 3 3 3 1 Transglutaminase family, C-terminal ig like domain Gryzun PF07919.7 ESS65862.1 - 0.011 14.0 0.0 0.019 13.2 0.0 1.3 1 1 0 1 1 1 0 Gryzun, putative trafficking through Golgi Filamin PF00630.14 ESS65862.1 - 0.13 12.8 0.0 0.29 11.7 0.0 1.6 1 0 0 1 1 1 0 Filamin/ABP280 repeat Y_Y_Y PF07495.8 ESS65862.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 Y_Y_Y domain DUF2076 PF09849.4 ESS65863.1 - 6.8e-08 32.8 4.3 7.7e-08 32.6 3.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 ESS65863.1 - 0.0011 18.8 3.3 0.0017 18.1 2.3 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 ESS65863.1 - 0.0061 16.5 1.1 0.0094 15.9 0.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 TMEM237 PF15383.1 ESS65863.1 - 0.097 11.7 0.3 0.14 11.2 0.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 237 IncA PF04156.9 ESS65863.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 IncA protein ABC2_membrane PF01061.19 ESS65867.1 - 9.7e-09 34.6 24.6 2e-08 33.6 17.1 1.5 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESS65867.1 - 7.5e-05 23.0 0.0 0.00019 21.7 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_4 PF12730.2 ESS65867.1 - 1.3 8.1 31.8 0.024 13.7 16.6 2.0 2 1 0 2 2 2 0 ABC-2 family transporter protein DUF4042 PF13251.1 ESS65869.1 - 6.9e-11 41.9 3.1 6.3e-09 35.5 0.1 3.7 3 1 0 3 3 3 2 Domain of unknown function (DUF4042) HEAT_2 PF13646.1 ESS65869.1 - 4.7e-10 39.6 5.3 0.0047 17.1 0.0 4.8 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.17 ESS65869.1 - 2.6e-06 27.0 6.5 0.3 11.2 0.1 5.9 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 ESS65869.1 - 6.1e-05 23.3 11.0 0.096 13.2 0.5 5.8 4 1 2 6 6 6 2 HEAT-like repeat BID PF06393.6 ESS65869.1 - 0.031 13.6 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 BH3 interacting domain (BID) Adaptin_N PF01602.15 ESS65869.1 - 0.22 9.8 0.0 0.75 8.0 0.0 1.6 1 1 0 2 2 2 0 Adaptin N terminal region HEAT PF02985.17 ESS65870.1 - 7.2e-06 25.6 0.2 0.24 11.5 0.0 4.5 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 ESS65870.1 - 0.0044 17.2 0.0 2.2 8.6 0.0 3.2 2 1 1 3 3 3 1 HEAT repeats DUF2631 PF10939.3 ESS65870.1 - 0.056 13.2 0.6 0.11 12.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) HEAT_EZ PF13513.1 ESS65870.1 - 0.091 13.2 0.0 5.4 7.6 0.0 3.3 2 2 1 3 3 3 0 HEAT-like repeat Pkinase PF00069.20 ESS65871.1 - 1.3e-06 27.7 0.0 1.8e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65871.1 - 4.1e-06 26.0 0.0 5.2e-06 25.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_9 PF14604.1 ESS65872.1 - 0.0028 17.1 0.1 0.0086 15.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain V-SNARE_C PF12352.3 ESS65872.1 - 0.029 14.4 0.4 0.11 12.5 0.3 2.0 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus LOH1CR12 PF10158.4 ESS65872.1 - 0.085 12.6 4.1 2.8 7.7 0.6 2.6 2 0 0 2 2 2 0 Tumour suppressor protein DUF3153 PF11353.3 ESS65872.1 - 0.16 11.3 8.4 1.2 8.4 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) Sec20 PF03908.8 ESS65872.1 - 0.47 10.1 4.7 0.39 10.4 0.1 2.8 3 0 0 3 3 3 0 Sec20 Retrotrans_gag PF03732.12 ESS65872.1 - 1 9.4 5.6 1.3 9.1 0.1 2.9 2 1 0 2 2 2 0 Retrotransposon gag protein UPF0122 PF04297.9 ESS65872.1 - 2.6 8.0 8.9 1.3 9.0 1.2 2.9 2 1 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like DZR PF12773.2 ESS65873.1 - 0.004 16.9 59.9 0.01 15.6 5.2 7.0 3 3 3 6 6 6 5 Double zinc ribbon Costars PF14705.1 ESS65874.1 - 1.5e-05 24.9 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Costars Nop14 PF04147.7 ESS65874.1 - 0.0044 15.0 6.1 0.0063 14.4 4.3 1.1 1 0 0 1 1 1 1 Nop14-like family Cytochrom_C PF00034.16 ESS65876.1 - 0.085 13.6 0.2 0.18 12.6 0.1 1.6 1 0 0 1 1 1 0 Cytochrome c Cytochrome_C554 PF13435.1 ESS65876.1 - 0.85 9.6 7.6 3.2 7.8 5.3 2.0 1 1 0 1 1 1 0 Cytochrome c554 and c-prime DUF4549 PF15082.1 ESS65877.1 - 0.066 12.8 0.5 0.11 12.0 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) Aminotran_5 PF00266.14 ESS65878.1 - 1e-08 34.3 0.0 1.4e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.20 ESS65880.1 - 7.1e-49 166.2 0.0 1.4e-36 125.9 0.0 2.1 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65880.1 - 2.6e-29 102.0 0.0 4e-29 101.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS65880.1 - 4.4e-09 35.7 0.0 1e-08 34.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pox_F11 PF04943.7 ESS65880.1 - 0.1 11.4 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus F11 protein Seadorna_VP7 PF07387.6 ESS65880.1 - 0.14 10.9 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pribosyltran PF00156.22 ESS65881.1 - 7.2e-13 48.3 0.1 1.8e-12 47.0 0.0 1.7 1 1 1 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESS65881.1 - 0.065 12.4 0.0 0.094 11.9 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Peptidase_M24 PF00557.19 ESS65883.1 - 1.2e-44 152.3 0.2 1.8e-44 151.7 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 FliE PF02049.13 ESS65883.1 - 6 6.9 9.2 44 4.1 6.2 2.5 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE Tropomyosin_1 PF12718.2 ESS65885.1 - 0.0076 16.1 12.7 0.0076 16.1 8.8 11.7 2 2 8 10 10 10 2 Tropomyosin like Myosin_tail_1 PF01576.14 ESS65886.1 - 0.14 9.8 20.9 0.043 11.5 8.7 2.2 2 0 0 2 2 2 0 Myosin tail IncA PF04156.9 ESS65886.1 - 1.7 8.1 19.4 0.5 9.9 5.9 2.6 2 0 0 2 2 2 0 IncA protein Tropomyosin_1 PF12718.2 ESS65886.1 - 9.3 6.0 19.2 1.5 8.6 1.1 3.3 2 1 0 2 2 2 0 Tropomyosin like Pkinase PF00069.20 ESS65887.1 - 5.4e-65 219.1 0.0 1.4e-58 198.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65887.1 - 8.4e-45 152.8 0.0 9.2e-39 133.0 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS65887.1 - 0.0022 17.7 0.0 0.0044 16.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS65887.1 - 0.0023 17.0 0.0 0.0044 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MKT1_N PF12247.3 ESS65890.1 - 4.8e-17 62.0 0.1 1.1e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_C PF12246.3 ESS65890.1 - 8.1e-10 38.1 0.0 1.4e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication tRNA-synt_1g PF09334.6 ESS65891.1 - 4.2e-111 371.3 0.0 5.6e-111 370.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ESS65891.1 - 3.2e-18 65.0 0.5 1.1e-08 33.5 0.8 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 ESS65891.1 - 1.2e-05 24.6 0.0 0.042 12.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 ESS65891.1 - 0.098 11.4 0.2 0.2 10.4 0.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (R) DUF1641 PF07849.6 ESS65891.1 - 0.17 11.5 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Not1 PF04054.10 ESS65893.1 - 5e-119 397.5 6.3 5e-119 397.5 4.4 2.2 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 DUF4011 PF13195.1 ESS65893.1 - 0.002 18.1 2.1 0.002 18.1 1.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4011) DUF4557 PF15101.1 ESS65893.1 - 0.0043 16.9 15.3 0.0043 16.9 10.6 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4557) Zip PF02535.17 ESS65893.1 - 0.058 12.3 2.1 0.14 11.1 1.5 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter UPF0542 PF15086.1 ESS65893.1 - 0.14 11.8 0.1 0.14 11.8 0.1 3.0 2 1 0 2 2 2 0 Uncharacterised protein family UPF0542 Neur_chan_memb PF02932.11 ESS65893.1 - 0.2 11.5 8.9 1.8 8.3 3.2 3.2 3 1 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Plasmodium_Vir PF05795.6 ESS65893.1 - 0.24 10.5 1.4 0.5 9.5 1.0 1.5 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4192 PF13830.1 ESS65893.1 - 0.28 10.7 1.7 0.62 9.6 1.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Baculo_PP31 PF05311.6 ESS65893.1 - 2.1 7.5 15.2 0.031 13.5 2.7 2.9 3 0 0 3 3 3 0 Baculovirus 33KDa late protein (PP31) TFIIA PF03153.8 ESS65893.1 - 8.6 6.1 30.8 0.072 12.9 12.0 2.8 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF3819 PF12842.2 ESS65894.1 - 1.8e-31 108.8 2.0 7.4e-31 106.8 1.4 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) TFIIA PF03153.8 ESS65894.1 - 1.8 8.3 27.9 0.19 11.5 13.5 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4557 PF15101.1 ESS65894.1 - 7.4 6.3 23.3 0.25 11.1 11.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) GAGA_bind PF06217.7 ESS65894.1 - 9.9 6.0 15.3 6.3 6.6 8.2 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Ras PF00071.17 ESS65895.1 - 2.8e-50 169.8 0.1 3.4e-50 169.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS65895.1 - 5.7e-20 72.0 0.1 1.7e-19 70.4 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESS65895.1 - 3.6e-11 42.6 0.0 4.7e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESS65895.1 - 2.6e-06 27.0 0.0 6e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESS65895.1 - 0.00039 19.6 0.0 0.00052 19.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESS65895.1 - 0.00063 19.6 0.0 0.0011 18.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESS65895.1 - 0.032 14.2 0.2 0.084 12.8 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.5 ESS65895.1 - 0.062 12.5 0.0 0.13 11.4 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 ESS65895.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain PCI PF01399.22 ESS65899.1 - 4.7e-11 42.9 0.1 2e-10 40.9 0.0 2.2 1 0 0 1 1 1 1 PCI domain Vps39_1 PF10366.4 ESS65899.1 - 0.058 13.4 11.4 8 6.5 0.1 5.2 2 2 4 6 6 6 0 Vacuolar sorting protein 39 domain 1 PD-C2-AF1 PF09310.5 ESS65899.1 - 0.088 11.9 0.0 14 4.7 0.0 2.2 2 0 0 2 2 2 0 POU domain, class 2, associating factor 1 WHIM1 PF15612.1 ESS65899.1 - 4.7 7.3 6.8 28 4.9 0.1 3.3 4 0 0 4 4 4 0 WSTF, HB1, Itc1p, MBD9 motif 1 Ribosomal_L36e PF01158.13 ESS65901.1 - 4.9e-11 42.4 0.0 8e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L36e Leu_Phe_trans PF03588.9 ESS65902.1 - 0.00024 20.2 0.1 0.0006 18.9 0.0 1.7 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase DSPc PF00782.15 ESS65903.1 - 1.7e-19 69.7 0.0 2.5e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ABC_tran PF00005.22 ESS65904.1 - 2.3e-38 131.5 0.0 6e-18 65.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 ESS65904.1 - 5.9e-16 59.2 1.4 0.0016 18.4 0.0 4.4 2 2 2 4 4 4 3 AAA domain SMC_N PF02463.14 ESS65904.1 - 7.6e-13 48.1 1.0 0.0031 16.7 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain RLI PF04068.10 ESS65904.1 - 4.8e-11 42.0 3.2 1.1e-10 40.8 2.2 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.22 ESS65904.1 - 2.2e-09 36.5 2.0 2.2e-09 36.5 1.4 2.5 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_15 PF13175.1 ESS65904.1 - 7.7e-09 35.0 0.1 0.089 11.8 0.0 4.3 4 0 0 4 4 4 2 AAA ATPase domain Fer4_6 PF12837.2 ESS65904.1 - 8.9e-07 28.5 12.7 2.5e-06 27.1 0.7 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_22 PF13401.1 ESS65904.1 - 3.2e-06 27.2 0.0 0.00073 19.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_29 PF13555.1 ESS65904.1 - 4.3e-06 26.1 0.1 0.011 15.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_7 PF12838.2 ESS65904.1 - 9.8e-06 25.8 8.1 9.1e-05 22.7 0.2 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_23 PF13476.1 ESS65904.1 - 2.4e-05 24.7 0.5 0.014 15.7 0.2 2.5 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 ESS65904.1 - 3e-05 24.4 0.0 0.0084 16.5 0.0 3.1 3 0 0 3 3 2 1 Miro-like protein DUF258 PF03193.11 ESS65904.1 - 8.1e-05 21.8 0.0 0.045 12.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS65904.1 - 0.00023 21.2 1.3 0.025 14.5 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 ESS65904.1 - 0.00027 20.9 0.0 0.18 11.7 0.0 2.6 3 0 0 3 3 2 1 AAA domain Fer4_2 PF12797.2 ESS65904.1 - 0.00041 20.0 2.0 0.00041 20.0 1.4 2.7 2 0 0 2 2 1 1 4Fe-4S binding domain AAA PF00004.24 ESS65904.1 - 0.00048 20.3 0.0 0.046 13.9 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) VirE PF05272.6 ESS65904.1 - 0.00049 19.6 0.1 0.15 11.5 0.0 2.5 2 0 0 2 2 2 1 Virulence-associated protein E NACHT PF05729.7 ESS65904.1 - 0.00053 19.6 1.0 0.013 15.1 0.0 2.6 3 0 0 3 3 2 1 NACHT domain Fer4_10 PF13237.1 ESS65904.1 - 0.00058 19.5 1.3 0.00058 19.5 0.9 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 ESS65904.1 - 0.0006 19.6 15.9 0.0016 18.2 11.1 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain AAA_17 PF13207.1 ESS65904.1 - 0.00066 20.4 0.3 1.5 9.6 0.0 3.2 2 2 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESS65904.1 - 0.00085 19.2 0.0 0.35 10.7 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.1 ESS65904.1 - 0.0012 18.3 0.1 1 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESS65904.1 - 0.0013 18.6 0.1 0.25 11.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain Fer4_9 PF13187.1 ESS65904.1 - 0.0019 18.4 13.4 0.0064 16.7 9.3 2.0 1 0 0 1 1 1 1 4Fe-4S dicluster domain RNA_helicase PF00910.17 ESS65904.1 - 0.0028 17.7 0.1 0.99 9.6 0.0 3.1 4 0 0 4 4 2 1 RNA helicase UPF0079 PF02367.12 ESS65904.1 - 0.0031 17.1 0.0 0.03 13.9 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Fer4_3 PF12798.2 ESS65904.1 - 0.0033 17.8 5.2 0.0033 17.8 3.6 2.7 2 0 0 2 2 1 1 4Fe-4S binding domain AAA_13 PF13166.1 ESS65904.1 - 0.0044 15.5 0.2 0.12 10.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_16 PF13484.1 ESS65904.1 - 0.005 17.5 7.2 0.0061 17.2 0.1 2.6 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain AAA_18 PF13238.1 ESS65904.1 - 0.0058 16.9 0.1 7.4 6.8 0.0 3.2 3 1 0 3 3 2 0 AAA domain SRP54 PF00448.17 ESS65904.1 - 0.0075 15.7 0.8 0.57 9.5 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_4 PF12800.2 ESS65904.1 - 0.008 16.4 2.0 0.008 16.4 1.4 2.6 2 0 0 2 2 1 1 4Fe-4S binding domain SbcCD_C PF13558.1 ESS65904.1 - 0.013 15.3 0.0 3.1 7.7 0.0 2.9 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Rad17 PF03215.10 ESS65904.1 - 0.021 13.5 0.0 2.1 6.8 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein MobB PF03205.9 ESS65904.1 - 0.024 14.3 0.5 2.5 7.8 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 ESS65904.1 - 0.026 14.2 0.2 1.6 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 ESS65904.1 - 0.05 13.1 0.0 3.7 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 ESS65904.1 - 0.05 13.5 0.3 4.8 7.1 0.0 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_19 PF13245.1 ESS65904.1 - 0.14 11.9 0.6 25 4.7 0.0 3.1 3 0 0 3 3 3 0 Part of AAA domain NB-ARC PF00931.17 ESS65904.1 - 0.15 10.8 0.2 5.3 5.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.4 ESS65904.1 - 0.18 11.2 2.0 0.37 10.2 0.0 2.4 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Fer4_17 PF13534.1 ESS65904.1 - 2 8.8 14.3 30 5.0 10.0 2.5 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESS65904.1 - 4.5 7.3 13.6 19 5.3 9.6 2.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain Hist_deacetyl PF00850.14 ESS65905.1 - 1.5e-45 155.8 0.0 1.9e-45 155.5 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain ParA PF10609.4 ESS65906.1 - 3.2e-30 103.8 0.1 6e-30 102.9 0.1 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESS65906.1 - 5.4e-19 68.3 0.1 7.4e-19 67.9 0.1 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 ESS65906.1 - 1.1e-07 31.2 0.0 1.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 ESS65906.1 - 9.4e-07 28.8 0.0 2.7e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 ESS65906.1 - 0.00011 21.4 0.2 0.00018 20.6 0.2 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_17 PF13207.1 ESS65906.1 - 0.00044 21.0 0.0 0.00082 20.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain ArgK PF03308.11 ESS65906.1 - 0.00099 17.9 0.1 0.0015 17.3 0.1 1.2 1 0 0 1 1 1 1 ArgK protein AAA_16 PF13191.1 ESS65906.1 - 0.0014 18.6 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 ESS65906.1 - 0.0017 17.3 0.1 0.0026 16.6 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain MobB PF03205.9 ESS65906.1 - 0.002 17.8 0.0 0.0044 16.7 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Fer4_NifH PF00142.13 ESS65906.1 - 0.0025 17.0 0.1 0.0054 15.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.1 ESS65906.1 - 0.003 16.9 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESS65906.1 - 0.0034 16.5 0.0 0.006 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 ESS65906.1 - 0.0053 17.0 0.1 0.0097 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain YhjQ PF06564.7 ESS65906.1 - 0.0094 15.3 0.1 0.015 14.6 0.1 1.3 1 0 0 1 1 1 1 YhjQ protein APS_kinase PF01583.15 ESS65906.1 - 0.019 14.6 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase NACHT PF05729.7 ESS65906.1 - 0.027 14.1 0.4 0.044 13.4 0.3 1.3 1 0 0 1 1 1 0 NACHT domain AAA_10 PF12846.2 ESS65906.1 - 0.039 13.3 0.2 0.058 12.8 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain IstB_IS21 PF01695.12 ESS65906.1 - 0.044 13.1 0.1 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.10 ESS65906.1 - 0.052 13.2 0.2 0.093 12.4 0.1 1.4 1 0 0 1 1 1 0 NTPase SRP54 PF00448.17 ESS65906.1 - 0.076 12.4 0.7 0.14 11.6 0.1 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.1 ESS65906.1 - 0.084 13.0 0.1 0.26 11.4 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESS65906.1 - 0.092 12.2 0.2 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain UPF0079 PF02367.12 ESS65906.1 - 0.098 12.2 0.5 0.2 11.2 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 ESS65906.1 - 0.1 12.7 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 RNA helicase ATP_bind_1 PF03029.12 ESS65906.1 - 0.12 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein KTI12 PF08433.5 ESS65906.1 - 0.19 10.8 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SMC_N PF02463.14 ESS65906.1 - 0.2 10.8 0.1 0.34 10.0 0.1 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain IMS PF00817.15 ESS65908.1 - 4.3e-42 143.4 0.1 6.5e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 ESS65908.1 - 3.4e-06 26.9 0.0 8.1e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DEAD PF00270.24 ESS65909.1 - 3.9e-17 62.2 0.0 3e-12 46.3 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65909.1 - 9.8e-14 50.9 0.0 2.2e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS65909.1 - 0.00034 20.5 0.0 0.00083 19.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HMG_box PF00505.14 ESS65912.1 - 0.00032 20.8 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESS65912.1 - 0.061 13.7 0.1 12 6.3 0.0 2.7 2 0 0 2 2 2 0 HMG-box domain OSCP PF00213.13 ESS65912.1 - 0.093 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit PGM_PMM_I PF02878.11 ESS65913.1 - 1.1e-30 105.9 0.0 1.9e-30 105.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 ESS65913.1 - 1.8e-24 85.9 0.0 6e-24 84.2 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 ESS65913.1 - 1.1e-09 38.1 0.0 2.6e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.11 ESS65913.1 - 1.4e-09 38.2 0.0 5.2e-09 36.3 0.0 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ACP_syn_III_C PF08541.5 ESS65922.1 - 0.019 14.9 0.1 0.03 14.3 0.0 1.3 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal LRR_6 PF13516.1 ESS65923.1 - 1.6e-16 58.4 4.2 0.95 9.7 0.0 10.4 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.2 ESS65923.1 - 8.6e-15 53.9 0.2 0.0038 16.7 0.0 7.6 5 3 3 8 8 8 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS65923.1 - 1e-11 43.1 8.9 2.7 8.3 0.0 10.4 12 0 0 12 12 12 3 Leucine Rich Repeat LRR_7 PF13504.1 ESS65923.1 - 2.1e-07 30.0 14.1 26 5.6 0.0 10.7 12 0 0 12 12 12 1 Leucine rich repeat LRR_8 PF13855.1 ESS65923.1 - 3.2e-05 23.5 10.5 0.0088 15.7 0.3 5.9 5 2 2 7 7 7 3 Leucine rich repeat Guanylate_cyc PF00211.15 ESS65925.1 - 4.3e-47 159.8 0.0 6.9e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.1 ESS65925.1 - 1.3e-15 57.6 1.3 6.2e-11 42.2 0.2 2.5 2 0 0 2 2 2 2 Periplasmic binding protein PrgI PF12666.2 ESS65925.1 - 0.0018 18.3 0.0 0.007 16.4 0.0 2.0 1 0 0 1 1 1 1 PrgI family protein DUF3328 PF11807.3 ESS65925.1 - 0.19 11.3 0.0 0.46 10.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Tnp_zf-ribbon_2 PF13842.1 ESS65927.1 - 0.076 13.4 1.6 0.14 12.5 1.1 1.4 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Ribosomal_L7Ae PF01248.21 ESS65929.1 - 0.0042 16.5 0.0 2.4 7.7 0.0 2.7 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF4591 PF15261.1 ESS65929.1 - 0.014 15.6 0.0 0.042 14.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4591) TFIID_30kDa PF03540.8 ESS65930.1 - 0.046 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit FA_hydroxylase PF04116.8 ESS65931.1 - 4.6e-10 39.8 19.0 1.1e-09 38.6 13.2 1.6 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily GHMP_kinases_C PF08544.8 ESS65932.1 - 7.3e-15 54.9 0.4 1.5e-14 53.9 0.3 1.6 1 1 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESS65932.1 - 2.7e-06 27.3 0.5 7.9e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain PDEase_I PF00233.14 ESS65933.1 - 1e-06 28.6 0.1 2.4e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase MT-A70 PF05063.9 ESS65933.1 - 0.0097 15.4 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 1 MT-A70 Arena_RNA_pol PF06317.6 ESS65933.1 - 0.014 12.0 0.0 0.018 11.6 0.0 1.1 1 0 0 1 1 1 0 Arenavirus RNA polymerase Mod_r PF07200.8 ESS65933.1 - 0.13 12.1 11.9 1.5 8.7 3.0 2.7 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Reo_sigmaC PF04582.7 ESS65933.1 - 0.16 11.1 3.8 6.9 5.7 0.9 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF641 PF04859.7 ESS65933.1 - 0.34 10.6 8.5 2.9 7.6 1.0 2.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF342 PF03961.8 ESS65933.1 - 0.49 8.7 3.5 3.4 5.9 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Fib_alpha PF08702.5 ESS65933.1 - 1.4 9.0 6.6 5 7.2 1.1 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 ESS65933.1 - 1.9 8.3 26.1 0.19 11.5 0.3 3.0 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding NPV_P10 PF05531.7 ESS65933.1 - 2.3 8.5 10.9 9.7 6.5 0.2 3.7 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein HOOK PF05622.7 ESS65933.1 - 3 5.5 25.5 0.2 9.4 6.8 2.3 1 1 1 2 2 2 0 HOOK protein DUF334 PF03904.8 ESS65933.1 - 4.4 6.5 10.0 0.081 12.2 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF334) DUF3450 PF11932.3 ESS65933.1 - 5.2 6.2 18.0 0.5 9.5 4.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) AAA_13 PF13166.1 ESS65933.1 - 6.9 4.9 13.5 55 2.0 9.6 1.8 1 1 0 1 1 1 0 AAA domain DUF3899 PF13038.1 ESS65934.1 - 0.0027 17.8 0.3 0.0049 16.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3899) ABC_membrane_2 PF06472.10 ESS65935.1 - 1.1e-36 126.3 2.7 1.5e-36 125.9 1.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESS65935.1 - 4e-17 62.8 0.0 6.4e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESS65935.1 - 0.00022 20.5 0.0 0.08 12.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 ESS65935.1 - 0.012 15.6 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.1 ESS65935.1 - 0.018 14.9 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESS65935.1 - 0.045 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 ESS65935.1 - 0.086 12.5 0.0 0.21 11.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF815 PF05673.8 ESS65935.1 - 0.095 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_23 PF13476.1 ESS65935.1 - 0.15 12.4 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESS65935.1 - 0.15 12.1 0.0 0.3 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ESS65935.1 - 0.18 12.0 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESS65935.1 - 0.19 10.3 0.0 0.39 9.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein TRM13 PF05206.9 ESS65937.1 - 1.8e-67 227.3 0.2 6.8e-66 222.1 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.3 ESS65937.1 - 3.8e-11 42.1 1.3 3.8e-11 42.1 0.9 3.1 4 0 0 4 4 4 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.7 ESS65937.1 - 2.1e-06 27.3 1.4 7e-06 25.6 1.0 2.0 1 1 0 1 1 1 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.1 ESS65937.1 - 0.0021 17.7 3.2 0.017 14.8 2.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain DnaJ PF00226.26 ESS65938.1 - 2.3e-22 78.4 0.1 4.3e-22 77.6 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESS65938.1 - 1.2e-08 34.4 0.4 3.4e-08 33.0 0.2 1.8 1 1 1 2 2 2 1 X-domain of DnaJ-containing ATG_C PF09333.6 ESS65938.1 - 0.086 12.9 0.3 0.44 10.7 0.2 2.2 1 1 1 2 2 2 0 ATG C terminal domain Antimicrobial_2 PF08023.7 ESS65938.1 - 6 7.2 6.0 12 6.3 2.1 2.7 3 0 0 3 3 3 0 Frog antimicrobial peptide Peptidase_C2 PF00648.16 ESS65940.1 - 1.7e-41 142.1 0.0 2.7e-41 141.5 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS65940.1 - 3.9e-17 62.1 0.0 7.6e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.16 ESS65941.1 - 2.3e-43 148.3 0.0 3.2e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS65941.1 - 5.9e-20 71.1 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Oxidored_q6 PF01058.17 ESS65941.1 - 0.0024 17.4 0.0 0.0056 16.2 0.0 1.5 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit VID27 PF08553.5 ESS65941.1 - 0.28 9.3 10.1 21 3.1 7.7 2.1 2 0 0 2 2 2 0 VID27 cytoplasmic protein TLP-20 PF06088.6 ESS65941.1 - 0.37 10.4 3.0 0.74 9.4 2.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Peptidase_C2 PF00648.16 ESS65942.1 - 2.5e-22 79.2 0.0 4.3e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS65942.1 - 6.2e-15 55.0 0.0 1.4e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) GMC_oxred_N PF00732.14 ESS65942.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Peptidase_C2 PF00648.16 ESS65943.1 - 9.3e-39 133.1 0.0 1.3e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.5 ESS65943.1 - 1.1e-25 89.6 0.0 1.8e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Kdo_hydroxy PF11004.3 ESS65944.1 - 0.038 12.9 0.1 0.91 8.4 0.0 2.6 2 1 1 3 3 3 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase Med9 PF07544.8 ESS65945.1 - 0.0036 17.0 0.9 0.012 15.3 0.3 2.1 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.7 ESS65945.1 - 0.011 16.1 0.1 0.039 14.3 0.1 2.0 1 0 0 1 1 1 0 SlyX CCDC144C PF14915.1 ESS65945.1 - 0.014 14.2 0.6 0.035 13.0 0.4 1.6 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region SNARE PF05739.14 ESS65945.1 - 0.055 13.1 0.8 0.11 12.1 0.6 1.5 1 0 0 1 1 1 0 SNARE domain PqqD PF05402.7 ESS65945.1 - 0.07 13.1 2.4 31 4.6 0.2 4.3 3 1 1 4 4 4 0 Coenzyme PQQ synthesis protein D (PqqD) Aa_trans PF01490.13 ESS65946.1 - 5.1e-36 124.0 20.3 6.8e-36 123.6 14.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.13 ESS65947.1 - 6.1e-52 176.4 33.4 6.1e-52 176.4 23.2 1.4 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS65947.1 - 2.2e-07 30.0 17.0 2.2e-07 30.0 11.8 2.8 3 0 0 3 3 3 1 Tryptophan/tyrosine permease family CRAL_TRIO PF00650.15 ESS65948.1 - 2.5e-12 46.5 0.0 4.4e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain ESSS PF10183.4 ESS65949.1 - 0.0048 17.2 1.6 0.0067 16.8 0.1 1.8 1 1 1 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) GPDPase_memb PF10110.4 ESS65949.1 - 0.011 15.1 1.4 0.016 14.6 0.1 1.8 2 0 0 2 2 2 0 Membrane domain of glycerophosphoryl diester phosphodiesterase 7tm_1 PF00001.16 ESS65949.1 - 0.018 14.1 0.6 0.018 14.1 0.4 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) BatD PF13584.1 ESS65949.1 - 0.034 12.7 0.2 0.042 12.4 0.2 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF2207 PF09972.4 ESS65949.1 - 0.036 12.6 0.1 0.036 12.6 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Zip PF02535.17 ESS65949.1 - 4.7 6.1 11.9 12 4.7 8.3 1.7 1 1 0 1 1 1 0 ZIP Zinc transporter Peptidase_S49_N PF08496.5 ESS65949.1 - 8.4 6.1 6.6 13 5.5 4.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CRAL_TRIO PF00650.15 ESS65950.1 - 1.1e-13 51.0 0.0 2.5e-13 49.8 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain Abhydrolase_6 PF12697.2 ESS65950.1 - 0.00012 21.9 2.3 0.0002 21.3 0.6 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Kinesin PF00225.18 ESS65951.1 - 3.3e-94 315.3 0.2 5.9e-94 314.4 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain RecO_C PF02565.10 ESS65951.1 - 0.03 14.1 0.1 0.075 12.8 0.1 1.7 1 0 0 1 1 1 0 Recombination protein O C terminal UPF0184 PF03670.8 ESS65951.1 - 0.058 13.5 1.4 0.42 10.8 0.0 3.0 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0184) DUF4200 PF13863.1 ESS65951.1 - 0.35 10.8 2.2 5.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) zf-C2H2_6 PF13912.1 ESS65952.1 - 0.054 13.4 1.2 0.3 11.0 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger DnaJ PF00226.26 ESS65953.1 - 7.8e-09 35.1 0.0 1.4e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DEAD PF00270.24 ESS65954.1 - 5.3e-08 32.5 0.0 1.8e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS65954.1 - 2e-07 30.7 0.0 6e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 ESS65954.1 - 0.00044 20.2 0.1 0.0036 17.2 0.0 2.7 2 1 0 2 2 2 1 Helicase associated domain (HA2) AAA_22 PF13401.1 ESS65954.1 - 0.00059 19.9 0.5 0.047 13.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS65954.1 - 0.0042 16.0 0.0 0.012 14.5 0.0 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein Cupin_4 PF08007.7 ESS65955.1 - 1.9e-42 145.6 1.1 2.6e-42 145.2 0.7 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.1 ESS65955.1 - 3.3e-08 33.3 0.1 8.6e-08 31.9 0.1 1.8 1 1 0 1 1 1 1 Cupin-like domain Tetraspannin PF00335.15 ESS65955.1 - 0.24 10.6 0.8 0.54 9.4 0.0 1.8 2 0 0 2 2 2 0 Tetraspanin family DUF869 PF05911.6 ESS65956.1 - 0.028 12.6 75.8 0.018 13.3 11.6 4.3 2 1 2 4 4 4 0 Plant protein of unknown function (DUF869) Reo_sigmaC PF04582.7 ESS65956.1 - 1.4 8.0 19.5 11 5.1 0.3 6.1 4 2 2 6 6 6 0 Reovirus sigma C capsid protein FERM_M PF00373.13 ESS65957.1 - 5.7e-19 68.5 0.1 9.3e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.5 ESS65957.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 FERM N-terminal domain LRR_6 PF13516.1 ESS65958.1 - 2.3e-14 51.8 3.7 0.49 10.6 0.0 8.1 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.28 ESS65958.1 - 8.8e-11 40.3 0.6 3.6 7.9 0.0 8.2 10 0 0 10 10 10 3 Leucine Rich Repeat LRR_4 PF12799.2 ESS65958.1 - 4e-10 39.0 0.2 0.0018 17.8 0.0 6.2 3 1 4 7 7 7 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESS65958.1 - 7.3e-06 25.3 9.1 13 6.4 0.0 8.3 10 0 0 10 10 10 2 Leucine rich repeat LRR_8 PF13855.1 ESS65958.1 - 5.1e-05 22.9 5.8 0.027 14.2 0.0 4.7 5 1 0 5 5 5 2 Leucine rich repeat WD40 PF00400.27 ESS65960.1 - 4.8e-37 124.5 5.1 3.8e-07 29.7 0.0 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat NLE PF08154.7 ESS65960.1 - 3.5e-15 55.7 0.9 5.5e-15 55.1 0.6 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 ESS65960.1 - 0.016 13.3 0.0 0.69 7.9 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 EF-hand_5 PF13202.1 ESS65961.1 - 0.0069 15.6 0.6 0.016 14.5 0.4 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 ESS65961.1 - 0.011 15.2 0.2 0.011 15.2 0.2 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 ESS65961.1 - 0.016 15.0 1.1 0.059 13.2 0.8 1.9 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.27 ESS65961.1 - 0.053 12.8 1.9 0.1 11.9 0.2 2.3 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.1 ESS65961.1 - 0.079 13.1 0.3 0.079 13.1 0.2 2.8 3 0 0 3 3 3 0 EF-hand domain pair Flagellin_N PF00669.15 ESS65961.1 - 0.086 12.6 2.3 0.21 11.3 1.6 1.7 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Nol1_Nop2_Fmu PF01189.12 ESS65962.1 - 6.5e-82 275.0 0.0 1.1e-81 274.3 0.0 1.4 2 0 0 2 2 2 1 NOL1/NOP2/sun family FtsJ PF01728.14 ESS65962.1 - 0.0004 20.4 0.0 0.0012 18.8 0.0 1.8 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 ESS65962.1 - 0.00086 19.8 0.6 0.032 14.7 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS65962.1 - 0.00089 18.8 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Atg14 PF10186.4 ESS65962.1 - 0.044 12.7 0.5 0.098 11.5 0.3 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 ESS65962.1 - 0.91 9.0 4.1 1.8 8.1 2.9 1.4 1 0 0 1 1 1 0 IncA protein HrpA_pilin PF09589.5 ESS65964.1 - 0.76 10.2 4.0 0.29 11.5 0.4 2.1 1 1 1 2 2 2 0 HrpA pilus formation protein V_ATPase_I PF01496.14 ESS65964.1 - 5.6 4.6 12.1 0.53 8.0 2.1 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family RNA_pol_Rpb2_6 PF00562.23 ESS65965.1 - 1.7e-120 402.3 0.0 2.3e-120 401.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 ESS65965.1 - 1.9e-40 137.9 0.0 3.2e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 ESS65965.1 - 8.1e-28 96.5 0.0 2e-27 95.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 ESS65965.1 - 1e-23 82.8 2.8 2e-23 81.9 2.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.9 ESS65965.1 - 2.1e-23 82.7 0.1 4.6e-23 81.6 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 ESS65965.1 - 2.1e-21 75.4 1.6 2.3e-21 75.2 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 ESS65965.1 - 2.4e-08 33.7 0.5 4.9e-08 32.8 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 OrfB_Zn_ribbon PF07282.6 ESS65965.1 - 0.24 11.0 4.6 0.15 11.7 1.5 1.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain UCH PF00443.24 ESS65967.1 - 2e-46 158.2 0.0 2.8e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS65967.1 - 2.1e-12 47.1 1.7 1.9e-11 43.9 1.2 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 ESS65967.1 - 3.2e-09 36.0 0.1 8.2e-09 34.7 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.5 ESS65967.1 - 4.6e-06 27.1 0.5 9.3e-06 26.1 0.1 1.8 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.1 ESS65967.1 - 0.0085 16.3 0.1 0.023 14.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain Phe_tRNA-synt_N PF02912.13 ESS65967.1 - 0.02 14.5 0.1 0.068 12.8 0.0 1.9 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain FTA4 PF13093.1 ESS65967.1 - 0.046 13.1 0.1 0.11 11.8 0.0 1.7 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 IER PF05760.7 ESS65967.1 - 0.047 13.6 0.4 0.085 12.7 0.3 1.4 1 0 0 1 1 1 0 Immediate early response protein (IER) AAA_14 PF13173.1 ESS65968.1 - 0.021 14.7 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESS65968.1 - 0.023 14.0 0.0 0.061 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Zot PF05707.7 ESS65968.1 - 0.068 12.6 0.0 0.089 12.2 0.0 1.1 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) MCM PF00493.18 ESS65969.1 - 0.011 14.5 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 0 MCM2/3/5 family Peptidase_M16_C PF05193.16 ESS65982.1 - 6.3e-22 78.1 0.0 1e-21 77.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ESS65982.1 - 5.8e-08 32.6 0.0 1.4e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) ECH PF00378.15 ESS65983.1 - 1.1e-45 155.6 0.0 1.7e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family 3HCDH_N PF02737.13 ESS65983.1 - 1.7e-40 138.6 0.0 2.9e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 ESS65983.1 - 4.9e-26 90.9 0.0 3e-15 56.3 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_3 PF03447.11 ESS65983.1 - 0.0017 18.7 0.0 0.067 13.5 0.0 2.6 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain TrkA_N PF02254.13 ESS65983.1 - 0.0018 18.2 0.1 0.0051 16.7 0.0 1.7 2 0 0 2 2 2 1 TrkA-N domain Saccharop_dh PF03435.13 ESS65983.1 - 0.011 14.7 0.0 0.018 14.0 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_2 PF03446.10 ESS65983.1 - 0.018 14.8 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_S49 PF01343.13 ESS65983.1 - 0.018 14.7 0.2 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 NAD_binding_7 PF13241.1 ESS65983.1 - 0.086 13.1 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding FrhB_FdhB_C PF04432.8 ESS65986.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Pkinase PF00069.20 ESS65987.1 - 1.4e-45 155.4 0.0 2.3e-45 154.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS65987.1 - 9.9e-16 57.5 0.0 1.8e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESS65987.1 - 0.037 12.8 0.0 0.067 11.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Baculo_Y142 PF04913.7 ESS65987.1 - 0.19 10.0 0.0 0.29 9.4 0.0 1.1 1 0 0 1 1 1 0 Baculovirus Y142 protein PEPCK_ATP PF01293.15 ESS65988.1 - 5.5e-198 658.1 0.0 6.5e-198 657.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 ESS65988.1 - 0.0018 18.1 0.0 0.059 13.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESS65988.1 - 0.058 13.3 0.0 0.23 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 ESS65988.1 - 0.13 11.7 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_13 PF13166.1 ESS65988.1 - 0.22 9.9 0.0 0.33 9.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain ADIP PF11559.3 ESS65989.1 - 5.9e-05 23.0 11.4 5.9e-05 23.0 7.9 9.9 5 3 5 11 11 11 2 Afadin- and alpha -actinin-Binding Tropomyosin PF00261.15 ESS65989.1 - 0.00045 19.3 10.3 0.00045 19.3 7.2 8.1 4 2 2 7 7 6 3 Tropomyosin Tropomyosin_1 PF12718.2 ESS65989.1 - 0.00091 19.0 11.1 0.00091 19.0 7.7 8.5 4 4 3 7 7 7 2 Tropomyosin like Filament PF00038.16 ESS65989.1 - 0.0014 18.2 17.3 0.0014 18.2 12.0 6.7 3 2 1 6 6 6 5 Intermediate filament protein ATG16 PF08614.6 ESS65989.1 - 0.0018 18.1 12.6 0.0018 18.1 8.8 7.8 1 1 6 7 7 7 1 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 ESS65989.1 - 0.0049 16.5 9.0 0.0049 16.5 6.3 9.0 7 2 1 9 9 9 1 TATA element modulatory factor 1 TATA binding CopC PF04234.7 ESS65989.1 - 0.047 14.3 0.2 0.27 11.9 0.1 2.3 1 0 0 1 1 1 0 CopC domain DUF2120 PF09893.4 ESS65989.1 - 0.069 13.1 1.4 0.27 11.1 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) bZIP_1 PF00170.16 ESS65989.1 - 0.19 11.7 0.1 0.19 11.7 0.1 9.5 10 1 0 10 10 9 0 bZIP transcription factor IncA PF04156.9 ESS65989.1 - 0.4 10.2 115.7 0.078 12.5 6.6 6.5 3 2 2 6 6 6 0 IncA protein DUF4279 PF14106.1 ESS65989.1 - 4.1 7.3 10.3 5.3 6.9 0.3 4.0 3 1 0 4 4 4 0 Domain of unknown function (DUF4279) Reo_sigmaC PF04582.7 ESS65989.1 - 7.6 5.6 14.7 12 4.9 0.1 5.1 5 1 0 5 5 5 0 Reovirus sigma C capsid protein MMR_HSR1 PF01926.18 ESS65990.1 - 1.6e-18 66.7 0.0 4.5e-18 65.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase YchF-GTPase_C PF06071.8 ESS65990.1 - 1.3e-15 56.8 0.0 2.7e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) FeoB_N PF02421.13 ESS65990.1 - 7.2e-08 31.8 0.1 5.9e-07 28.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.16 ESS65990.1 - 0.0059 16.4 0.0 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 TGS domain DUF258 PF03193.11 ESS65990.1 - 0.052 12.7 0.0 0.15 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESS65990.1 - 0.075 13.8 0.0 0.16 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain DSPc PF00782.15 ESS65991.1 - 1.9e-24 85.7 0.0 3.3e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS65991.1 - 0.0027 17.0 0.0 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Flagellar_rod PF05149.7 ESS65992.1 - 1.5e-110 368.9 29.3 1.5e-110 368.9 20.3 1.9 2 0 0 2 2 2 1 Paraflagellar rod protein SH3_1 PF00018.23 ESS65992.1 - 2.4e-12 46.0 0.0 5.7e-12 44.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESS65992.1 - 4.2e-12 45.4 0.0 9.6e-12 44.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESS65992.1 - 3.4e-07 29.6 0.0 7.4e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Prefoldin PF02996.12 ESS65993.1 - 0.012 15.2 1.6 13 5.5 0.2 3.2 3 0 0 3 3 3 0 Prefoldin subunit GSP_synth PF03738.9 ESS65995.1 - 7.2e-29 99.9 0.3 1.5e-28 98.9 0.2 1.6 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CHAP PF05257.11 ESS65995.1 - 2.8e-21 75.4 0.0 5.4e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 CHAP domain Mre11_DNA_bind PF04152.9 ESS65997.1 - 2.7e-32 112.0 0.0 4.6e-32 111.2 0.0 1.4 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 ESS65997.1 - 8.9e-20 70.9 0.9 1.2e-19 70.4 0.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf-MIZ PF02891.15 ESS65999.1 - 2.9e-20 71.5 0.8 1.4e-19 69.3 0.6 2.2 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 ESS65999.1 - 0.034 13.6 0.1 0.08 12.4 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.1 ESS65999.1 - 0.047 13.4 0.3 0.13 12.0 0.2 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein PPR_3 PF13812.1 ESS66000.1 - 0.0097 16.1 2.3 6.1 7.4 0.0 4.4 4 0 0 4 4 4 1 Pentatricopeptide repeat domain BTAD PF03704.12 ESS66000.1 - 0.054 13.7 0.0 0.054 13.7 0.0 3.2 3 1 1 4 4 4 0 Bacterial transcriptional activator domain PPR PF01535.15 ESS66000.1 - 0.13 12.3 0.0 5.3 7.2 0.0 3.3 3 0 0 3 3 3 0 PPR repeat PPR_2 PF13041.1 ESS66000.1 - 0.14 12.1 0.1 1.6 8.7 0.0 2.8 3 1 1 4 4 4 0 PPR repeat family Pkinase PF00069.20 ESS66002.1 - 4.4e-50 170.2 0.1 1.9e-44 151.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66002.1 - 1.3e-25 89.9 0.0 2e-22 79.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS66002.1 - 3.1e-08 32.9 0.0 4.9e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like WSK PF03832.8 ESS66002.1 - 0.61 9.4 2.1 1.3 8.4 1.4 1.6 1 0 0 1 1 1 0 WSK motif Dpy-30 PF05186.8 ESS66003.1 - 2.6e-08 33.1 0.0 4.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Dpy-30 motif ADK PF00406.17 ESS66003.1 - 0.019 14.8 0.0 0.062 13.1 0.0 1.8 1 0 0 1 1 1 0 Adenylate kinase Epimerase PF01370.16 ESS66003.1 - 0.1 12.0 0.1 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Spb1_C PF07780.7 ESS66004.1 - 6.7e-34 117.2 21.4 6.7e-34 117.2 14.9 3.2 3 1 1 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.3 ESS66004.1 - 2.3e-27 95.4 0.3 2.3e-27 95.4 0.2 4.4 4 1 0 4 4 4 1 Domain of unknown function (DUF3381) FtsJ PF01728.14 ESS66004.1 - 1.4e-11 44.7 0.1 2.8e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase RabGAP-TBC PF00566.13 ESS66005.1 - 1.2e-27 96.8 1.5 5.9e-25 88.0 0.4 2.8 2 1 0 2 2 2 2 Rab-GTPase-TBC domain ubiquitin PF00240.18 ESS66006.1 - 0.00069 18.9 0.0 0.0016 17.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Mito_carr PF00153.22 ESS66008.1 - 1e-30 105.3 0.2 2.2e-14 52.9 0.1 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Claudin_2 PF13903.1 ESS66010.1 - 5.6e-06 26.1 8.4 6.9e-06 25.8 5.3 1.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2079 PF09852.4 ESS66010.1 - 0.0059 15.3 2.3 0.0059 15.3 1.6 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2079) EcsB PF05975.7 ESS66010.1 - 0.015 13.8 0.5 0.071 11.5 0.0 1.9 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB DUF4064 PF13273.1 ESS66010.1 - 0.062 13.4 0.4 1.1 9.3 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) ATG27 PF09451.5 ESS66012.1 - 1.4 8.0 0.0 1.4 8.0 0.0 2.5 3 0 0 3 3 3 0 Autophagy-related protein 27 RRM_1 PF00076.17 ESS66013.1 - 1.6e-27 94.9 0.1 1.5e-13 50.1 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66013.1 - 3e-22 78.3 0.4 9e-10 38.4 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS66013.1 - 7.2e-10 38.5 0.0 0.0005 19.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESS66013.1 - 1.5e-05 24.6 0.0 0.0012 18.5 0.0 2.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF4651 PF15513.1 ESS66013.1 - 0.016 14.6 0.0 2.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) RRM_3 PF08777.6 ESS66013.1 - 0.018 14.9 0.1 0.38 10.6 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif RNA_bind PF08675.6 ESS66013.1 - 0.048 13.6 0.0 3.9 7.5 0.0 2.4 2 0 0 2 2 2 0 RNA binding domain TC1 PF15063.1 ESS66013.1 - 0.074 12.5 0.2 0.64 9.6 0.0 2.1 2 0 0 2 2 2 0 Thyroid cancer protein 1 Smg4_UPF3 PF03467.10 ESS66013.1 - 0.11 12.4 0.3 18 5.2 0.0 2.9 3 0 0 3 3 3 0 Smg-4/UPF3 family DNA_ligase_IV PF11411.3 ESS66013.1 - 0.85 9.4 4.5 3.5 7.4 0.0 3.0 3 0 0 3 3 3 0 DNA ligase IV Glyco_transf_22 PF03901.12 ESS66014.1 - 2.4e-32 112.4 21.1 4.3e-32 111.6 14.6 1.3 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Motile_Sperm PF00635.21 ESS66015.1 - 3.3e-08 33.1 0.5 7.8e-08 31.9 0.4 1.7 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Pkinase PF00069.20 ESS66016.1 - 5.8e-43 146.9 0.0 6.9e-38 130.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66016.1 - 4.4e-23 81.6 0.0 1.2e-22 80.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 ESS66016.1 - 0.0012 18.0 0.0 0.0023 17.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS66016.1 - 0.0069 16.1 1.8 0.058 13.1 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS66016.1 - 0.16 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Atg14 PF10186.4 ESS66017.1 - 0.042 12.8 24.0 0.014 14.3 9.1 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 ESS66017.1 - 0.044 12.8 34.9 0.047 12.7 5.9 2.5 2 1 0 2 2 2 0 Autophagy protein Apg6 OmpH PF03938.9 ESS66017.1 - 0.86 9.5 28.5 0.37 10.7 12.4 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3584 PF12128.3 ESS66017.1 - 1.1 6.5 30.2 0.29 8.3 5.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) WXG100 PF06013.7 ESS66017.1 - 3.6 7.6 14.2 10 6.1 3.1 3.7 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF3810 PF12725.2 ESS66017.1 - 3.7 6.3 6.1 1.3 7.7 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) ERM PF00769.14 ESS66017.1 - 4.2 6.8 36.1 3.6 7.0 13.4 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF4407 PF14362.1 ESS66017.1 - 6.5 5.6 18.6 0.8 8.5 6.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) WD40 PF00400.27 ESS66019.1 - 9.2e-13 47.5 11.3 0.0023 17.7 0.1 8.3 10 1 0 10 10 10 3 WD domain, G-beta repeat CENP-F_leu_zip PF10473.4 ESS66019.1 - 0.0062 16.4 13.9 0.0062 16.4 9.6 5.9 2 2 4 6 6 6 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 ESS66019.1 - 0.25 10.4 9.9 0.024 13.8 1.4 3.2 2 1 0 3 3 3 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 ESS66019.1 - 3 5.0 72.7 2 5.6 31.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) NIF PF03031.13 ESS66020.1 - 4.1e-33 114.3 0.1 6.2e-33 113.7 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ins_allergen_rp PF06757.8 ESS66020.1 - 0.06 12.8 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification Thioredoxin PF00085.15 ESS66021.1 - 1.2e-06 28.0 0.0 2.2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.11 ESS66021.1 - 0.00014 20.7 0.6 0.0002 20.1 0.2 1.3 1 1 0 1 1 1 1 Phosducin DSPc PF00782.15 ESS66022.1 - 3.9e-30 104.1 0.0 6.2e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS66022.1 - 0.0011 18.3 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Tweety PF04906.8 ESS66031.1 - 0.00058 18.3 0.0 0.00084 17.8 0.0 1.2 1 0 0 1 1 1 1 Tweety Ion_trans_2 PF07885.11 ESS66033.1 - 1.4e-10 40.7 6.0 1.4e-10 40.7 4.2 2.5 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.26 ESS66033.1 - 0.0049 16.1 2.4 0.0049 16.1 1.7 2.7 3 0 0 3 3 3 1 Ion transport protein Lig_chan PF00060.21 ESS66033.1 - 0.03 14.0 1.7 0.054 13.2 0.6 1.8 1 1 0 1 1 1 0 Ligand-gated ion channel HDAC4_Gln PF12203.3 ESS66034.1 - 0.12 12.3 2.4 0.33 10.9 1.7 1.8 1 1 0 1 1 1 0 Glutamine rich N terminal domain of histone deacetylase 4 WD40 PF00400.27 ESS66035.1 - 7.2e-35 117.6 11.5 1e-05 25.1 0.0 10.7 12 0 0 12 12 12 7 WD domain, G-beta repeat Utp12 PF04003.7 ESS66035.1 - 3e-07 30.3 0.1 1.1e-06 28.5 0.1 1.9 1 1 0 1 1 1 1 Dip2/Utp12 Family RAB3GAP2_N PF14655.1 ESS66035.1 - 0.011 14.7 0.1 0.031 13.3 0.0 1.7 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus P16-Arc PF04699.9 ESS66035.1 - 0.068 13.1 0.1 0.29 11.1 0.1 2.0 1 1 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) SpoU_methylase PF00588.14 ESS66037.1 - 6.4e-16 58.5 0.0 1.4e-15 57.4 0.0 1.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family DUF4206 PF13901.1 ESS66040.1 - 2e-17 63.4 19.1 6.3e-13 48.7 1.3 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4206) Prok-RING_1 PF14446.1 ESS66040.1 - 0.003 17.2 5.8 0.003 17.2 4.0 3.8 4 0 0 4 4 4 1 Prokaryotic RING finger family 1 CDC27 PF09507.5 ESS66040.1 - 0.009 15.2 1.2 0.009 15.2 0.8 2.0 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 ELO PF01151.13 ESS66041.1 - 2.2e-73 246.6 12.9 2.5e-73 246.4 9.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.13 ESS66042.1 - 1.9e-69 233.7 17.0 2.2e-69 233.5 11.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.13 ESS66043.1 - 1e-81 273.9 21.8 1.2e-81 273.7 15.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.13 ESS66044.1 - 3.9e-77 258.9 23.3 4.6e-77 258.7 16.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family FHIPEP PF00771.15 ESS66045.1 - 0.08 11.2 0.5 0.19 10.0 0.0 1.7 2 0 0 2 2 2 0 FHIPEP family Ras PF00071.17 ESS66046.1 - 7.4e-38 129.4 0.0 9.9e-38 129.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS66046.1 - 3.4e-16 59.8 0.0 6.4e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS66046.1 - 3.4e-05 23.1 0.0 5.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.1 ESS66046.1 - 0.00031 20.8 0.1 0.00084 19.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 ESS66046.1 - 0.0016 18.4 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESS66046.1 - 0.013 14.7 0.0 0.027 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MobB PF03205.9 ESS66046.1 - 0.013 15.2 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B KaiC PF06745.8 ESS66046.1 - 0.016 14.3 0.1 0.052 12.6 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_16 PF13191.1 ESS66046.1 - 0.018 15.0 0.2 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ArgK PF03308.11 ESS66046.1 - 0.029 13.1 0.1 0.64 8.7 0.0 2.1 2 0 0 2 2 2 0 ArgK protein NACHT PF05729.7 ESS66046.1 - 0.034 13.7 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 ESS66046.1 - 0.036 14.3 0.0 0.067 13.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA PF00004.24 ESS66046.1 - 0.04 14.1 0.0 0.095 12.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DAP3 PF10236.4 ESS66046.1 - 0.05 12.5 0.0 0.09 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.1 ESS66046.1 - 0.14 11.7 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DivIVA PF05103.8 ESS66047.1 - 0.0077 16.2 3.0 0.0077 16.2 2.1 5.8 6 0 0 6 6 6 2 DivIVA protein DUF4201 PF13870.1 ESS66049.1 - 1.6e-41 141.6 15.9 1.6e-41 141.6 11.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4201) Sua5_yciO_yrdC PF01300.13 ESS66049.1 - 0.00093 18.4 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Telomere recombination Snapin_Pallidin PF14712.1 ESS66049.1 - 0.037 14.3 0.5 0.037 14.3 0.3 3.8 4 1 1 5 5 5 0 Snapin/Pallidin DUF948 PF06103.6 ESS66049.1 - 0.057 13.2 8.6 0.38 10.6 0.2 3.3 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) TMF_DNA_bd PF12329.3 ESS66049.1 - 0.058 13.1 22.6 0.13 12.0 0.5 4.9 4 1 0 4 4 4 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 ESS66049.1 - 1.5 9.2 20.2 1.6 9.1 0.3 5.1 5 0 0 5 5 5 0 SlyX COG5 PF10392.4 ESS66049.1 - 2.9 7.8 10.5 0.26 11.2 1.5 2.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Pkinase PF00069.20 ESS66050.1 - 1.4e-45 155.4 0.0 4.3e-40 137.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66050.1 - 1.2e-14 54.0 0.0 1.6e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS66050.1 - 0.0014 18.3 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Helicase_C PF00271.26 ESS66051.1 - 3.2e-15 55.7 0.0 7.5e-15 54.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 ESS66051.1 - 2.7e-05 23.1 0.0 0.00062 18.6 0.0 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SNF2_N PF00176.18 ESS66052.1 - 9.3e-67 224.9 0.1 1.7e-66 224.0 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 ESS66052.1 - 1.2e-07 31.3 0.0 3.2e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS66052.1 - 0.00019 21.3 0.0 0.0017 18.2 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESS66052.1 - 0.013 15.6 0.0 0.066 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3490 PF11995.3 ESS66052.1 - 0.037 13.6 1.3 0.082 12.4 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) AAA_11 PF13086.1 ESS66052.1 - 0.038 13.5 0.1 0.038 13.5 0.1 2.7 2 1 0 2 2 2 0 AAA domain PP2C PF00481.16 ESS66057.1 - 8e-56 189.2 0.0 1.1e-55 188.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESS66057.1 - 0.00016 21.1 0.0 0.00029 20.3 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C GSH_synth_ATP PF03917.12 ESS66058.1 - 1.2e-60 205.1 0.0 3.6e-60 203.5 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 ESS66058.1 - 3.8e-35 120.1 0.0 7.8e-35 119.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Rdx PF10262.4 ESS66058.1 - 0.077 13.0 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 Rdx family DNA_pol_A PF00476.15 ESS66059.1 - 5.8e-30 104.1 0.7 9.9e-30 103.4 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family A ARGLU PF15346.1 ESS66060.1 - 0.032 13.9 3.7 0.062 13.0 2.1 1.8 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 PAP_assoc PF03828.14 ESS66062.1 - 7e-16 57.9 0.0 2.2e-15 56.3 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase Mito_carr PF00153.22 ESS66063.1 - 9.6e-33 111.7 0.0 5.4e-14 51.6 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.22 ESS66064.1 - 1.4e-07 31.0 0.1 1.6e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein Rota_Capsid_VP6 PF00980.12 ESS66068.1 - 0.09 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Rotavirus major capsid protein VP6 COQ9 PF08511.6 ESS66069.1 - 0.0011 18.3 0.0 0.67 9.5 0.0 2.3 2 0 0 2 2 2 2 COQ9 Pkinase PF00069.20 ESS66070.1 - 1.8e-43 148.5 0.0 4.5e-43 147.2 0.0 1.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66070.1 - 1e-18 67.3 0.0 6.2e-18 64.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESS66070.1 - 0.019 14.6 0.0 0.053 13.2 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESS66070.1 - 0.073 12.4 0.1 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Thioredoxin_7 PF13899.1 ESS66071.1 - 0.0062 16.5 0.0 0.022 14.7 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like PQ-loop PF04193.9 ESS66072.1 - 7.6e-27 92.6 5.9 1.2e-14 53.6 0.1 2.7 3 0 0 3 3 3 2 PQ loop repeat Cytomega_TRL10 PF06084.6 ESS66072.1 - 0.0069 16.2 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Cytomegalovirus TRL10 protein MARVEL PF01284.18 ESS66072.1 - 1.6 8.5 7.8 0.41 10.4 2.7 1.9 2 0 0 2 2 2 0 Membrane-associating domain Pkinase PF00069.20 ESS66081.1 - 1.8e-24 86.3 0.4 5.3e-09 35.6 0.0 4.3 4 1 0 4 4 4 4 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66081.1 - 9.2e-10 38.0 0.0 0.0023 17.0 0.0 4.3 4 1 0 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.20 ESS66082.1 - 0.0033 16.6 0.0 0.01 14.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Surp PF01805.15 ESS66083.1 - 0.0012 18.4 2.6 0.0012 18.4 1.8 2.5 2 1 0 2 2 2 1 Surp module RCR PF12273.3 ESS66083.1 - 0.66 10.5 21.7 0.22 12.0 9.2 2.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red Pex2_Pex12 PF04757.9 ESS66084.1 - 3.9e-69 232.5 3.9 4.6e-69 232.3 2.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 ESS66084.1 - 6.5e-05 22.8 5.2 0.00012 22.0 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS66084.1 - 0.036 13.7 7.5 0.055 13.1 5.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS66084.1 - 0.094 12.5 4.2 0.17 11.7 2.9 1.4 1 0 0 1 1 1 0 Ring finger domain OAF PF14941.1 ESS66084.1 - 0.31 10.1 1.5 0.46 9.5 1.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator, Out at first DUF755 PF05501.6 ESS66088.1 - 1.8 8.6 24.4 3.1 7.8 16.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) Seryl_tRNA_N PF02403.17 ESS66088.1 - 7.5 6.6 15.8 9.7 6.2 11.0 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain RRM_1 PF00076.17 ESS66089.1 - 2e-12 46.5 0.0 3.5e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66089.1 - 1.1e-07 31.6 0.0 1.9e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS66089.1 - 2.1e-07 30.6 0.0 4.9e-07 29.5 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.18 ESS66091.1 - 1.7e-85 286.6 0.6 2.3e-85 286.2 0.4 1.1 1 0 0 1 1 1 1 Kinesin motor domain Apc3 PF12895.2 ESS66093.1 - 0.0025 17.9 0.7 0.007 16.4 0.5 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 ESS66093.1 - 0.027 14.3 2.4 0.041 13.8 0.8 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS66093.1 - 0.074 13.0 0.2 0.31 11.0 0.2 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS66093.1 - 0.1 13.1 0.8 0.32 11.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66093.1 - 0.16 11.9 2.6 0.24 11.3 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESS66093.1 - 0.23 11.3 0.1 0.23 11.3 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Fcf1 PF04900.7 ESS66094.1 - 8.4e-36 122.1 2.1 2e-35 120.8 1.4 1.7 1 0 0 1 1 1 1 Fcf1 Actin PF00022.14 ESS66095.1 - 5.7e-99 331.2 0.0 6.4e-99 331.0 0.0 1.0 1 0 0 1 1 1 1 Actin YTV PF07639.6 ESS66098.1 - 0.04 13.6 0.1 0.13 12.0 0.1 1.8 1 0 0 1 1 1 0 YTV Lebercilin PF15619.1 ESS66099.1 - 0.014 14.8 4.0 0.014 14.8 2.8 3.6 4 1 0 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Cluap1 PF10234.4 ESS66099.1 - 0.031 13.5 6.8 0.03 13.5 1.9 2.3 2 0 0 2 2 2 0 Clusterin-associated protein-1 COMP PF11598.3 ESS66099.1 - 0.13 12.3 0.1 0.13 12.3 0.1 3.3 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein DUF3972 PF13118.1 ESS66099.1 - 0.27 11.2 3.4 0.58 10.2 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) WD40_alt PF14077.1 ESS66099.1 - 0.73 9.5 3.6 1.1 8.8 0.8 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif Spc7 PF08317.6 ESS66099.1 - 1.3 7.5 10.1 0.85 8.2 4.0 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein Milton PF12448.3 ESS66100.1 - 0.03 14.5 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 Kinesin associated protein TerB-C PF15615.1 ESS66100.1 - 0.72 10.0 4.5 0.55 10.4 0.1 2.5 1 1 1 2 2 2 0 TerB-C domain WD40 PF00400.27 ESS66102.1 - 3.8e-29 99.4 8.6 3.7e-05 23.4 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat Tir_receptor_N PF07490.6 ESS66102.1 - 0.012 15.2 0.2 0.027 14.0 0.1 1.5 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus B_lectin PF01453.19 ESS66102.1 - 0.056 13.3 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 D-mannose binding lectin Ank_2 PF12796.2 ESS66104.1 - 2.1e-38 130.5 5.8 4.7e-08 33.2 0.2 8.9 6 3 2 8 8 8 6 Ankyrin repeats (3 copies) Ank PF00023.25 ESS66104.1 - 3.6e-28 95.9 23.4 4.9e-05 22.9 0.0 12.0 12 0 0 12 12 12 6 Ankyrin repeat Ank_5 PF13857.1 ESS66104.1 - 2.4e-23 81.6 9.1 0.0003 20.9 0.0 9.5 9 0 0 9 9 9 6 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS66104.1 - 6.3e-20 71.1 13.6 0.00021 21.7 0.1 8.3 6 1 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS66104.1 - 4.4e-18 63.5 16.4 0.0069 16.5 0.0 11.4 12 0 0 12 12 12 4 Ankyrin repeat SPRY PF00622.23 ESS66104.1 - 1.1e-07 31.9 0.0 4.1e-07 30.1 0.0 1.9 1 1 0 1 1 1 1 SPRY domain PCI PF01399.22 ESS66105.1 - 8.8e-09 35.6 0.0 3.2e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 PCI domain Mito_carr PF00153.22 ESS66106.1 - 1.6e-40 136.6 3.5 6.1e-19 67.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SlyX PF04102.7 ESS66107.1 - 1.9 8.9 8.2 10 6.5 0.1 4.3 3 2 1 4 4 4 0 SlyX APC10 PF03256.11 ESS66108.1 - 1.2e-47 162.0 0.0 3e-47 160.7 0.0 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.20 ESS66108.1 - 0.0016 18.2 0.0 0.0033 17.2 0.0 1.6 1 0 0 1 1 1 1 F5/8 type C domain DAGK_cat PF00781.19 ESS66111.1 - 4e-11 42.4 0.0 7.1e-06 25.4 0.1 2.8 2 1 0 2 2 2 2 Diacylglycerol kinase catalytic domain B2 PF11473.3 ESS66112.1 - 0.0084 15.6 2.9 0.011 15.2 0.0 2.7 3 1 1 4 4 4 1 RNA binding protein B2 REV PF00424.13 ESS66112.1 - 0.92 9.4 8.0 5.2 7.0 0.1 3.4 2 2 0 3 3 3 0 REV protein (anti-repression trans-activator protein) DUF1664 PF07889.7 ESS66112.1 - 5 6.9 13.2 0.35 10.6 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) PseudoU_synth_1 PF01416.15 ESS66113.1 - 5e-11 42.9 0.0 2.7e-08 34.1 0.0 3.5 3 1 0 3 3 3 2 tRNA pseudouridine synthase WRKY PF03106.10 ESS66113.1 - 0.076 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 WRKY DNA -binding domain WD40 PF00400.27 ESS66114.1 - 5.2e-22 76.8 11.4 2.6e-06 27.0 0.5 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ESS66114.1 - 0.0087 15.7 0.1 0.26 10.9 0.0 2.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_3 PF13570.1 ESS66114.1 - 0.03 14.5 1.9 4.8 7.6 0.0 3.5 4 0 0 4 4 4 0 PQQ-like domain FYVE PF01363.16 ESS66115.1 - 1e-13 50.9 10.0 1e-13 50.9 6.9 2.1 2 1 0 2 2 2 1 FYVE zinc finger FKBP_C PF00254.23 ESS66116.1 - 1.1e-05 25.2 0.0 2.6e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CAP_GLY PF01302.20 ESS66118.1 - 9.6e-11 41.2 0.1 1.6e-10 40.5 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain MT PF12777.2 ESS66118.1 - 0.26 9.9 14.0 0.035 12.8 5.9 2.1 1 1 1 2 2 2 0 Microtubule-binding stalk of dynein motor DUF2294 PF10057.4 ESS66119.1 - 0.011 15.4 1.5 0.031 13.9 0.4 2.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2294) Vps53_N PF04100.7 ESS66120.1 - 9.4e-64 215.5 3.7 1.4e-63 215.0 2.6 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal COG7 PF10191.4 ESS66120.1 - 4.8e-06 24.8 2.5 7.8e-06 24.1 1.8 1.2 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) COG2 PF06148.6 ESS66120.1 - 0.012 15.4 2.3 0.034 13.9 0.3 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RepL PF05732.6 ESS66120.1 - 0.074 12.2 0.0 0.2 10.8 0.0 1.7 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) ABC_tran PF00005.22 ESS66121.1 - 1.4e-44 151.7 0.0 5.8e-22 78.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 ESS66121.1 - 5.4e-21 75.8 2.8 5.5e-08 33.1 0.5 4.1 3 1 0 3 3 3 3 AAA domain ABC_tran_2 PF12848.2 ESS66121.1 - 7.8e-21 73.7 3.0 7.8e-21 73.7 2.1 2.8 4 0 0 4 4 2 1 ABC transporter SMC_N PF02463.14 ESS66121.1 - 1.1e-09 37.8 2.5 0.0044 16.2 0.4 4.0 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ESS66121.1 - 1.9e-09 38.3 1.0 0.0023 18.7 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.1 ESS66121.1 - 1.9e-08 34.6 0.1 0.0069 16.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA PF00004.24 ESS66121.1 - 3.5e-07 30.4 0.0 0.0064 16.6 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 ESS66121.1 - 6.4e-07 29.9 2.9 0.077 13.3 1.8 3.2 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESS66121.1 - 1e-06 28.1 0.0 0.071 12.6 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.1 ESS66121.1 - 1.2e-06 28.6 0.0 0.03 14.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 ESS66121.1 - 2.1e-06 27.6 0.0 0.14 12.0 0.0 3.5 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.17 ESS66121.1 - 2.2e-06 27.7 0.0 0.012 15.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_16 PF13191.1 ESS66121.1 - 3.6e-06 27.0 0.7 0.014 15.3 0.0 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.1 ESS66121.1 - 1.2e-05 25.1 0.1 0.12 12.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.1 ESS66121.1 - 1.6e-05 24.4 0.0 0.16 11.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ESS66121.1 - 2.5e-05 24.4 0.1 0.22 11.6 0.1 3.1 2 1 0 2 2 2 2 AAA domain NACHT PF05729.7 ESS66121.1 - 2.9e-05 23.7 0.1 0.087 12.4 0.0 2.9 3 0 0 3 3 3 2 NACHT domain AAA_5 PF07728.9 ESS66121.1 - 4.5e-05 23.1 0.0 0.045 13.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Miro PF08477.8 ESS66121.1 - 7.2e-05 23.2 0.0 0.12 12.8 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein DUF258 PF03193.11 ESS66121.1 - 7.9e-05 21.8 0.0 0.29 10.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESS66121.1 - 9.9e-05 21.9 0.1 0.35 10.2 0.0 3.1 3 0 0 3 3 3 2 AAA-like domain Arch_ATPase PF01637.13 ESS66121.1 - 0.00017 21.3 0.0 0.081 12.6 0.0 2.7 3 0 0 3 3 3 1 Archaeal ATPase MobB PF03205.9 ESS66121.1 - 0.00018 21.2 0.1 0.06 13.0 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.1 ESS66121.1 - 0.0002 20.5 0.0 0.4 9.6 0.0 3.6 4 0 0 4 4 4 1 AAA ATPase domain PduV-EutP PF10662.4 ESS66121.1 - 0.00026 20.4 0.0 0.26 10.7 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.1 ESS66121.1 - 0.00059 19.5 0.0 0.058 13.1 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_13 PF13166.1 ESS66121.1 - 0.00084 17.9 3.4 0.6 8.5 0.0 3.8 3 1 1 4 4 4 1 AAA domain UPF0079 PF02367.12 ESS66121.1 - 0.0018 17.8 0.0 0.025 14.2 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 SbcCD_C PF13558.1 ESS66121.1 - 0.0028 17.5 0.1 0.44 10.5 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Mg_chelatase PF01078.16 ESS66121.1 - 0.0043 16.2 0.0 2.5 7.2 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 ESS66121.1 - 0.0043 16.1 0.1 0.13 11.3 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.18 ESS66121.1 - 0.0054 16.6 0.0 6.2 6.8 0.0 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.1 ESS66121.1 - 0.0064 16.0 0.0 1.2 8.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 ESS66121.1 - 0.0069 15.1 0.0 0.27 9.8 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein IstB_IS21 PF01695.12 ESS66121.1 - 0.0088 15.4 0.0 2 7.7 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein NB-ARC PF00931.17 ESS66121.1 - 0.0096 14.8 0.0 3.6 6.3 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.20 ESS66121.1 - 0.011 15.2 0.0 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 ESS66121.1 - 0.017 14.8 0.1 0.76 9.4 0.0 2.5 2 0 0 2 2 2 0 NTPase ArgK PF03308.11 ESS66121.1 - 0.02 13.6 0.5 0.75 8.5 0.0 2.5 3 0 0 3 3 3 0 ArgK protein SRP54 PF00448.17 ESS66121.1 - 0.022 14.2 0.1 0.61 9.5 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RuvB_N PF05496.7 ESS66121.1 - 0.027 13.5 0.0 0.36 9.8 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus G-alpha PF00503.15 ESS66121.1 - 0.037 12.7 0.0 1.8 7.1 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Sigma54_activ_2 PF14532.1 ESS66121.1 - 0.043 13.8 0.0 0.87 9.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Dynamin_N PF00350.18 ESS66121.1 - 0.052 13.3 0.0 1.7 8.4 0.0 3.0 2 1 0 2 2 2 0 Dynamin family Arf PF00025.16 ESS66121.1 - 0.073 12.3 0.2 0.99 8.6 0.0 2.7 3 0 0 3 3 3 0 ADP-ribosylation factor family cobW PF02492.14 ESS66121.1 - 0.096 12.1 2.0 2.3 7.6 0.0 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 ESS66121.1 - 0.14 11.9 0.2 4.4 7.0 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 Apc3 PF12895.2 ESS66122.1 - 1.9e-10 40.7 21.0 1.3e-06 28.4 2.8 5.8 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 SRP72 PF08492.7 ESS66122.1 - 7.4e-10 39.0 1.2 7.4e-10 39.0 0.8 2.5 3 0 0 3 3 2 1 SRP72 RNA-binding domain TPR_19 PF14559.1 ESS66122.1 - 4.2e-09 36.6 27.0 0.41 11.0 0.0 7.6 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66122.1 - 5.8e-06 26.4 20.3 6 7.7 0.2 8.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66122.1 - 1.5e-05 25.5 22.8 0.8 10.4 0.6 7.9 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS66122.1 - 0.00038 20.0 17.6 4.2 7.1 5.0 6.2 5 1 0 5 5 5 1 TPR repeat TPR_6 PF13174.1 ESS66122.1 - 0.0051 17.1 17.6 1.7 9.2 1.6 8.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66122.1 - 0.047 13.6 28.0 0.6 10.0 2.2 6.4 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS66122.1 - 0.054 13.3 7.8 0.48 10.3 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66122.1 - 0.083 12.5 5.6 11 5.7 1.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66122.1 - 0.21 11.5 22.4 8.3 6.6 0.4 7.0 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS66122.1 - 8.9 6.7 10.5 27 5.2 0.3 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat V-SNARE_C PF12352.3 ESS66123.1 - 3.8e-08 33.2 7.6 1.2e-07 31.7 0.6 2.5 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 ESS66123.1 - 0.009 15.7 0.1 0.046 13.4 0.0 2.0 2 0 0 2 2 2 1 Sec20 DIRP PF06584.8 ESS66123.1 - 0.033 14.0 0.7 0.086 12.7 0.3 1.8 1 1 0 1 1 1 0 DIRP Mucin PF01456.12 ESS66129.1 - 0.11 12.3 2.9 0.14 11.9 2.0 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein NADH-G_4Fe-4S_3 PF10588.4 ESS66130.1 - 8.7e-17 60.0 0.3 8.7e-17 60.0 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.1 ESS66130.1 - 3.8e-12 45.8 0.1 1e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.22 ESS66130.1 - 1.8e-08 34.0 0.1 5.1e-08 32.5 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_18 PF13746.1 ESS66130.1 - 0.019 15.3 3.5 0.05 14.0 2.4 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.2 ESS66130.1 - 0.18 11.7 0.2 0.18 11.7 0.1 2.5 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_7 PF12838.2 ESS66130.1 - 0.31 11.4 8.6 0.11 12.8 1.9 2.8 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.1 ESS66130.1 - 0.95 9.7 6.4 0.62 10.3 2.4 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain WD40 PF00400.27 ESS66133.1 - 0.00053 19.7 1.9 0.58 10.1 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_3 PF13570.1 ESS66133.1 - 0.16 12.2 1.8 2.5 8.4 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain DUF3648 PF12364.3 ESS66135.1 - 1.3e-18 67.3 0.7 3.1e-18 66.1 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3648) DnaJ PF00226.26 ESS66136.1 - 2.3e-16 59.2 1.4 2.3e-16 59.2 1.0 2.0 2 0 0 2 2 2 1 DnaJ domain PUF PF00806.14 ESS66137.1 - 5.5e-47 154.6 8.3 9.4e-07 27.9 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat SURF6 PF04935.7 ESS66137.1 - 0.16 11.2 5.4 0.3 10.3 3.8 1.4 1 0 0 1 1 1 0 Surfeit locus protein 6 Ribosomal_L34e PF01199.13 ESS66138.1 - 1.6e-27 95.5 4.3 1.6e-27 95.5 3.0 3.2 2 0 0 2 2 2 1 Ribosomal protein L34e DUF1656 PF07869.7 ESS66139.1 - 2.2 8.1 8.5 9.3 6.1 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) E1_dh PF00676.15 ESS66140.1 - 8.4e-106 353.0 0.0 1e-105 352.7 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 ESS66140.1 - 0.0018 17.2 0.0 0.0036 16.2 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase HSP70 PF00012.15 ESS66141.1 - 2.2e-113 379.2 0.0 1.4e-112 376.6 0.0 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESS66141.1 - 0.0041 15.7 0.0 0.012 14.2 0.0 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.11 ESS66141.1 - 0.048 13.2 0.0 0.093 12.3 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain SPT6_acidic PF14632.1 ESS66141.1 - 2.9 8.1 11.5 9 6.5 8.0 1.9 1 1 0 1 1 1 0 Acidic N-terminal SPT6 Cep57_CLD_2 PF14197.1 ESS66142.1 - 0.012 15.5 11.9 0.012 15.5 8.2 10.3 6 1 2 9 9 9 0 Centrosome localisation domain of PPC89 Reo_sigmaC PF04582.7 ESS66142.1 - 3.8 6.5 22.6 7.4 5.6 0.0 5.5 2 1 1 5 5 5 0 Reovirus sigma C capsid protein zf-CCCH PF00642.19 ESS66144.1 - 0.00058 19.4 8.8 0.026 14.2 0.8 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS66144.1 - 0.21 11.6 0.1 0.21 11.6 0.1 3.0 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type zf-CCCH PF00642.19 ESS66145.1 - 0.16 11.6 16.7 0.52 10.0 4.2 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS66145.1 - 3.4 7.7 11.3 0.77 9.8 0.1 3.8 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type zf-CCCH PF00642.19 ESS66146.1 - 0.022 14.4 8.0 0.8 9.4 2.7 3.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS66146.1 - 0.72 9.9 5.4 24 5.1 0.0 3.6 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type zf-CCCH PF00642.19 ESS66147.1 - 0.86 9.3 17.5 0.68 9.6 0.2 2.9 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) CTP_transf_2 PF01467.21 ESS66149.1 - 2.5e-11 43.8 0.0 4.8e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase CDP-OH_P_transf PF01066.16 ESS66149.1 - 8.7e-09 35.5 0.2 8.7e-09 35.5 0.1 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase FAD_syn PF06574.7 ESS66149.1 - 0.016 14.8 0.4 1.2 8.7 0.0 2.8 3 0 0 3 3 3 0 FAD synthetase DPM3 PF08285.6 ESS66149.1 - 2.5 7.9 5.6 12 5.7 1.8 2.7 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF2417 PF10329.4 ESS66149.1 - 8.9 5.6 13.0 0.95 8.8 5.5 1.9 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Phytochelatin PF05023.9 ESS66150.1 - 0.004 16.1 0.0 0.0064 15.4 0.0 1.3 1 0 0 1 1 1 1 Phytochelatin synthase Phytochelatin PF05023.9 ESS66151.1 - 0.0029 16.5 0.0 3.7 6.4 0.0 3.1 3 0 0 3 3 3 3 Phytochelatin synthase Acetyltransf_1 PF00583.19 ESS66152.1 - 0.00012 22.0 0.1 0.00092 19.1 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESS66152.1 - 0.0036 17.4 0.1 0.1 12.7 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESS66152.1 - 0.035 14.2 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Mito_carr PF00153.22 ESS66153.1 - 5.8e-30 102.8 2.8 1e-11 44.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein MCRS_N PF13325.1 ESS66154.1 - 1e-05 25.1 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein Myb_DNA-binding PF00249.26 ESS66154.1 - 0.00016 21.6 0.1 0.00033 20.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESS66154.1 - 0.00036 20.5 0.0 0.00078 19.4 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PIH1 PF08190.7 ESS66155.1 - 1.6e-33 116.5 1.0 2.8e-23 82.8 0.0 4.0 3 1 0 3 3 3 2 pre-RNA processing PIH1/Nop17 Cuticle_1 PF08140.6 ESS66156.1 - 0.1 12.4 0.1 3.4 7.5 0.0 2.5 2 0 0 2 2 2 0 Crustacean cuticle protein repeat FixH PF05751.6 ESS66157.1 - 2.4 7.9 4.1 3 7.6 2.9 1.1 1 0 0 1 1 1 0 FixH SET PF00856.23 ESS66158.1 - 1.1e-05 25.8 0.0 2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 SET domain RHS PF03527.9 ESS66158.1 - 0.11 12.3 0.7 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 RHS protein UQ_con PF00179.21 ESS66159.1 - 0.00069 19.0 0.0 0.0015 17.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ProRS-C_1 PF09180.6 ESS66160.1 - 4.3e-26 90.6 1.4 4.3e-26 90.6 1.0 2.2 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA_edit PF04073.10 ESS66160.1 - 4.1e-24 84.7 0.2 6.6e-24 84.1 0.1 1.3 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2b PF00587.20 ESS66160.1 - 3.9e-19 68.8 0.1 7.1e-19 68.0 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESS66160.1 - 3e-12 46.3 0.0 7.1e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Cys_rich_CWC PF14375.1 ESS66160.1 - 0.27 11.1 4.5 2.3 8.2 0.6 2.8 2 1 0 2 2 2 0 Cysteine-rich CWC Nbs1_C PF08599.5 ESS66162.1 - 9 6.2 8.4 1.4 8.8 1.8 2.8 2 0 0 2 2 2 0 DNA damage repair protein Nbs1 zf-C3HC4_3 PF13920.1 ESS66163.1 - 3.2e-15 55.5 10.7 5.5e-15 54.7 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS66163.1 - 6.5e-09 35.6 14.8 1.2e-08 34.8 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS66163.1 - 2.7e-05 23.8 13.1 4.9e-05 23.0 9.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESS66163.1 - 0.069 12.8 11.5 0.13 12.0 8.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Peptidase_M9 PF01752.12 ESS66163.1 - 0.13 11.1 1.1 0.17 10.7 0.1 1.6 2 0 0 2 2 2 0 Collagenase zf-P11 PF03854.9 ESS66163.1 - 1.5 8.3 8.3 3.4 7.2 5.8 1.6 1 1 0 1 1 1 0 P-11 zinc finger HdeA PF06411.6 ESS66164.1 - 0.19 11.6 1.3 0.49 10.3 0.9 1.6 1 0 0 1 1 1 0 HdeA/HdeB family zf-AN1 PF01428.11 ESS66165.1 - 2.7e-18 65.5 20.1 4.9e-10 39.1 3.4 3.0 2 1 1 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.10 ESS66165.1 - 1.7e-05 24.9 16.2 0.0033 17.5 2.2 2.6 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain Nol1_Nop2_Fmu PF01189.12 ESS66166.1 - 8.6e-26 90.9 0.0 1e-24 87.4 0.0 2.4 1 1 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 ESS66166.1 - 0.00011 22.2 0.0 0.0022 17.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain POR PF01558.13 ESS66166.1 - 0.023 14.5 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase FtsJ PF01728.14 ESS66166.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ank_2 PF12796.2 ESS66167.1 - 6e-25 87.4 0.5 3.1e-12 46.6 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 ESS66167.1 - 1.6e-24 84.4 0.6 1.4e-07 30.9 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 ESS66167.1 - 2.7e-21 75.4 3.7 2.4e-06 27.8 0.1 5.4 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS66167.1 - 5.7e-20 69.4 0.6 0.00011 22.0 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 ESS66167.1 - 8.6e-18 63.9 1.4 2.1e-08 34.1 0.1 4.9 3 1 2 5 5 5 4 Ankyrin repeats (many copies) PDEase_I PF00233.14 ESS66168.1 - 4.2e-67 226.3 3.8 7.1e-67 225.6 2.6 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DivIC PF04977.10 ESS66168.1 - 5.3e-05 22.6 0.8 5.3e-05 22.6 0.6 2.5 2 1 1 3 3 3 1 Septum formation initiator DUF4515 PF14988.1 ESS66168.1 - 0.0087 15.7 4.4 0.017 14.7 3.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) PsaM PF07465.8 ESS66168.1 - 0.36 10.4 1.2 0.77 9.4 0.8 1.6 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) Pkinase PF00069.20 ESS66169.1 - 1.5e-72 243.9 0.0 1.7e-72 243.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66169.1 - 5.3e-37 127.2 0.0 6.7e-37 126.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS66169.1 - 9.1e-06 24.8 0.0 1.7e-05 23.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Vps16_C PF04840.7 ESS66170.1 - 2.6e-23 82.4 2.1 1.2e-11 44.1 0.0 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region DUF217 PF02697.9 ESS66170.1 - 0.02 15.1 0.7 0.39 11.0 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized ACR, COG1753 Vps16_N PF04841.8 ESS66171.1 - 6.1e-42 143.5 0.0 4.5e-41 140.7 0.0 1.9 1 1 0 1 1 1 1 Vps16, N-terminal region Calpain_III PF01067.17 ESS66172.1 - 0.031 13.9 0.5 0.32 10.6 0.1 2.6 2 2 0 2 2 2 0 Calpain large subunit, domain III PTPlike_phytase PF14566.1 ESS66180.1 - 2.7e-112 371.5 0.3 4.2e-42 143.7 0.0 3.6 3 0 0 3 3 3 3 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 ESS66180.1 - 0.039 14.1 0.0 4.4 7.5 0.0 3.4 4 0 0 4 4 4 0 Tyrosine phosphatase family zf-DHHC PF01529.15 ESS66181.1 - 7.3e-32 110.1 3.6 7.3e-32 110.1 2.5 2.2 1 1 1 2 2 2 1 DHHC palmitoyltransferase Peptidase_M50 PF02163.17 ESS66181.1 - 0.091 11.7 0.0 0.15 10.9 0.0 1.4 1 1 0 1 1 1 0 Peptidase family M50 DUF2628 PF10947.3 ESS66181.1 - 4.5 7.1 14.9 2.3 8.0 2.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2628) zf-DHHC PF01529.15 ESS66182.1 - 8e-36 123.0 11.0 8e-36 123.0 7.6 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.1 ESS66182.1 - 0.017 14.9 0.1 0.029 14.1 0.1 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF805 PF05656.9 ESS66182.1 - 3.9 7.3 7.9 0.69 9.7 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Fer2_3 PF13085.1 ESS66183.1 - 6.6e-30 103.1 0.1 1.2e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.22 ESS66183.1 - 0.0045 16.7 0.6 0.017 14.8 0.4 2.0 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DEAD PF00270.24 ESS66184.1 - 4.6e-17 62.0 0.0 1.6e-16 60.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS66184.1 - 7.4e-11 41.7 0.0 1.8e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 ESS66184.1 - 0.00012 22.2 0.1 0.00031 20.8 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.1 ESS66184.1 - 0.001 18.9 0.0 0.0024 17.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) ResIII PF04851.10 ESS66184.1 - 0.017 14.9 0.0 0.058 13.2 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit TfoX_C PF04994.8 ESS66184.1 - 0.077 12.9 0.1 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 TfoX C-terminal domain Thioredoxin PF00085.15 ESS66185.1 - 0.072 12.7 0.0 0.58 9.8 0.0 2.3 2 1 0 2 2 2 0 Thioredoxin Mito_carr PF00153.22 ESS66186.1 - 5.5e-40 134.9 3.8 8.2e-19 67.1 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.11 ESS66186.1 - 0.0063 16.3 1.8 0.013 15.2 0.1 2.1 2 0 0 2 2 2 1 UcrQ family HSBP1 PF06825.7 ESS66187.1 - 0.21 11.1 2.1 0.75 9.4 1.0 2.1 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Radical_SAM PF04055.16 ESS66188.1 - 8.7e-13 48.7 0.0 6.6e-12 45.9 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 ESS66188.1 - 1.8e-07 31.1 0.2 4.6e-07 29.7 0.1 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESS66188.1 - 0.0073 16.4 0.1 0.018 15.1 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Tail_P2_I PF09684.5 ESS66189.1 - 0.12 11.9 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 Phage tail protein (Tail_P2_I) DNA_pol_B PF00136.16 ESS66190.1 - 2.7e-62 211.0 0.0 3.8e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.1 ESS66190.1 - 1.9e-05 24.5 5.2 0.00012 22.0 3.6 2.2 1 1 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B PF00136.16 ESS66191.1 - 2.6e-13 49.6 0.1 4.1e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESS66191.1 - 7.6e-13 48.0 0.0 2e-06 26.9 0.0 3.1 3 0 0 3 3 3 2 DNA polymerase family B, exonuclease domain Lactamase_B_2 PF12706.2 ESS66192.1 - 5.1e-11 42.4 0.0 8.9e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESS66192.1 - 3e-07 30.2 0.1 4.7e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily He_PIG_assoc PF10632.4 ESS66192.1 - 0.11 11.8 0.0 0.29 10.4 0.0 1.7 1 0 0 1 1 1 0 He_PIG associated, NEW1 domain of bacterial glycohydrolase SAP PF02037.22 ESS66192.1 - 0.12 11.9 0.4 0.32 10.5 0.0 1.9 2 0 0 2 2 2 0 SAP domain Dynein_heavy PF03028.10 ESS66193.1 - 9.9e-202 671.7 0.0 2.6e-201 670.3 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESS66193.1 - 2.7e-121 404.9 8.6 2.7e-121 404.9 6.0 4.0 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS66193.1 - 6.7e-95 317.0 0.0 2.1e-94 315.3 0.0 1.9 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N1 PF08385.7 ESS66193.1 - 7.8e-82 275.4 0.0 7.8e-82 275.4 0.0 3.2 2 1 0 2 2 1 1 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.2 ESS66193.1 - 5.6e-70 235.3 0.0 1.5e-69 233.9 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.2 ESS66193.1 - 2e-53 181.2 0.1 8.4e-53 179.1 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_9 PF12781.2 ESS66193.1 - 1.4e-52 177.7 0.9 3.7e-52 176.4 0.6 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS66193.1 - 1.5e-43 148.8 14.3 3.8e-43 147.5 9.9 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESS66193.1 - 2.2e-24 85.7 0.6 1.6e-09 37.5 0.0 6.3 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA PF00004.24 ESS66193.1 - 1.5e-07 31.6 1.0 0.058 13.5 0.0 4.7 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS66193.1 - 4e-06 27.6 0.1 5.5 7.8 0.0 5.7 4 0 0 4 4 3 2 AAA domain AAA_18 PF13238.1 ESS66193.1 - 0.00013 22.2 5.3 3.5 7.9 0.0 5.5 5 0 0 5 5 4 1 AAA domain Sigma54_activat PF00158.21 ESS66193.1 - 0.0002 20.8 0.0 0.033 13.6 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.1 ESS66193.1 - 0.00043 20.1 0.1 2.2 8.1 0.0 4.4 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESS66193.1 - 0.0009 19.2 5.7 0.5 10.3 0.0 5.4 5 0 0 5 5 4 1 AAA ATPase domain AAA_22 PF13401.1 ESS66193.1 - 0.0013 18.9 11.8 0.22 11.6 0.0 5.8 6 0 0 6 6 4 2 AAA domain AAA_19 PF13245.1 ESS66193.1 - 0.0021 17.7 4.1 2.6 7.8 0.6 3.6 3 0 0 3 3 3 1 Part of AAA domain RNA_helicase PF00910.17 ESS66193.1 - 0.0026 17.8 0.1 2 8.6 0.0 3.9 3 0 0 3 3 3 1 RNA helicase FtsK_SpoIIIE PF01580.13 ESS66193.1 - 0.0056 16.1 0.0 1.8 7.9 0.0 2.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family Mg_chelatase PF01078.16 ESS66193.1 - 0.0074 15.4 0.1 2.1 7.4 0.0 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 ESS66193.1 - 0.021 14.2 0.2 1.1 8.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain MobB PF03205.9 ESS66193.1 - 0.035 13.8 0.5 5.1 6.7 0.0 3.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Glyco_transf_5 PF08323.6 ESS66193.1 - 0.042 13.3 0.0 0.65 9.4 0.0 2.4 2 0 0 2 2 2 0 Starch synthase catalytic domain ResIII PF04851.10 ESS66193.1 - 0.48 10.2 11.5 1.4 8.7 0.0 4.3 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit UPF0079 PF02367.12 ESS66193.1 - 1.4 8.5 8.9 18 4.9 0.1 4.1 4 0 0 4 4 4 0 Uncharacterised P-loop hydrolase UPF0079 XPG_I PF00867.13 ESS66195.1 - 1.5e-23 82.6 1.5 2e-23 82.2 0.0 2.0 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.12 ESS66195.1 - 2.7e-16 59.6 0.0 3.2e-15 56.2 0.0 2.2 1 1 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 ESS66195.1 - 5e-05 22.9 0.6 0.00011 21.7 0.4 1.5 1 0 0 1 1 1 1 XPG domain containing DUF4611 PF15387.1 ESS66196.1 - 0.0078 16.3 0.3 0.015 15.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) DUF2244 PF10003.4 ESS66197.1 - 5.9 6.2 6.3 8.2 5.7 4.3 1.3 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) RICTOR_M PF14666.1 ESS66198.1 - 1.2e-58 197.8 0.0 2.5e-58 196.7 0.0 1.6 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_N PF14664.1 ESS66198.1 - 3.2e-15 55.5 3.5 4.5e-13 48.5 1.3 2.7 2 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.1 ESS66198.1 - 3.3e-07 30.2 4.9 2.4e-06 27.4 0.6 3.5 3 1 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 ESS66198.1 - 5.8e-05 22.9 0.6 0.001 18.9 0.1 3.3 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.15 ESS66198.1 - 0.05 11.9 0.1 0.28 9.4 0.1 2.0 2 0 0 2 2 2 0 Adaptin N terminal region DUF3250 PF11618.3 ESS66200.1 - 3.4e-33 114.0 0.2 3.4e-33 114.0 0.2 3.2 4 0 0 4 4 4 1 Protein of unknown function (DUF3250) Porin_2 PF02530.9 ESS66201.1 - 0.0081 15.2 1.8 0.019 14.0 0.0 2.0 2 0 0 2 2 2 1 Porin subfamily PPR_2 PF13041.1 ESS66202.1 - 3.9e-06 26.7 0.0 0.0051 16.7 0.0 2.5 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.1 ESS66202.1 - 0.00027 20.9 0.4 0.015 15.4 0.0 3.0 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR PF01535.15 ESS66202.1 - 0.0051 16.7 0.1 0.016 15.1 0.1 1.9 1 0 0 1 1 1 1 PPR repeat PPR_1 PF12854.2 ESS66202.1 - 0.0067 15.8 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 PPR repeat Cpn60_TCP1 PF00118.19 ESS66203.1 - 5.1e-148 493.6 5.2 5.9e-148 493.4 3.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fumerase_C PF05683.7 ESS66203.1 - 0.057 12.5 0.1 0.17 11.0 0.0 1.8 2 0 0 2 2 2 0 Fumarase C-terminus Methyltransf_5 PF01795.14 ESS66204.1 - 1.7e-30 106.3 0.0 2.5e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltransf_26 PF13659.1 ESS66204.1 - 8.3e-07 29.0 0.0 3.4e-06 27.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS66204.1 - 1.8e-06 27.6 0.0 0.00053 19.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 ESS66204.1 - 0.031 14.8 0.0 2.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Ribosomal_S9 PF00380.14 ESS66205.1 - 4.9e-06 26.7 0.0 9.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 WD40 PF00400.27 ESS66206.1 - 4.9e-21 73.7 3.8 4e-06 26.4 0.1 4.6 6 0 0 6 6 6 3 WD domain, G-beta repeat DUF1900 PF08954.6 ESS66206.1 - 1.9e-09 37.1 0.0 3.4e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 ESS66206.1 - 5.6e-07 29.1 0.0 1.1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) Peptidase_M17 PF00883.16 ESS66208.1 - 9.4e-97 323.6 0.0 1.2e-96 323.2 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.12 ESS66208.1 - 1.4e-07 31.3 0.2 5.5e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain CHB_HEX_C PF03174.8 ESS66209.1 - 2.5e-12 46.4 0.2 4.4e-07 29.6 0.3 4.0 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C_1 PF13290.1 ESS66209.1 - 7.9e-10 38.3 0.6 6.1e-05 22.7 0.1 3.3 3 1 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 ESS66209.1 - 1.6e-09 37.6 0.5 0.00014 21.8 0.1 3.4 4 0 0 4 4 4 2 Fn3 associated DUF2207 PF09972.4 ESS66211.1 - 0.011 14.4 3.0 0.012 14.2 2.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FA_desaturase PF00487.19 ESS66211.1 - 0.029 13.7 4.5 0.021 14.2 2.4 1.2 1 1 0 1 1 1 0 Fatty acid desaturase TMCO5 PF14992.1 ESS66211.1 - 8.9 5.3 6.6 11 5.0 4.6 1.1 1 0 0 1 1 1 0 TMCO5 family LMSTEN PF07988.7 ESS66214.1 - 0.058 12.6 1.7 0.16 11.2 1.2 1.8 1 0 0 1 1 1 0 LMSTEN motif KIAA1430 PF13879.1 ESS66215.1 - 0.016 15.5 1.0 0.016 15.5 0.7 2.5 1 1 1 2 2 2 0 KIAA1430 homologue 5-FTHF_cyc-lig PF01812.15 ESS66216.1 - 3.7e-19 69.2 0.1 6.1e-12 45.6 0.0 2.3 2 0 0 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family HIT PF01230.18 ESS66217.1 - 1.6e-12 47.7 0.1 3.6e-12 46.6 0.1 1.6 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ESS66217.1 - 0.0063 16.7 0.1 0.023 14.9 0.0 1.8 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF2410 PF10307.4 ESS66218.1 - 1.6e-07 30.8 0.0 2.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) HAD_2 PF13419.1 ESS66218.1 - 0.082 13.1 0.0 0.71 10.0 0.0 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Crl PF07417.7 ESS66219.1 - 0.11 12.2 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Crl Crl PF07417.7 ESS66220.1 - 0.026 14.2 0.0 0.079 12.6 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator Crl LRR_4 PF12799.2 ESS66221.1 - 6.2e-19 67.1 13.0 0.001 18.6 0.0 8.1 4 2 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS66221.1 - 5.9e-08 32.3 17.9 0.42 10.3 0.2 6.3 3 1 3 7 7 7 6 Leucine rich repeat LRR_6 PF13516.1 ESS66221.1 - 8.7e-05 22.2 14.1 5.9 7.2 0.2 8.8 8 1 0 8 8 8 1 Leucine Rich repeat LRR_7 PF13504.1 ESS66221.1 - 0.0045 16.9 20.3 0.95 9.9 0.0 9.5 10 1 0 10 10 10 1 Leucine rich repeat GlcNAc PF11397.3 ESS66230.1 - 2.4e-125 418.1 0.0 2.8e-125 417.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) Laminin_II PF06009.7 ESS66232.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Laminin Domain II MscS_porin PF12795.2 ESS66232.1 - 0.31 10.3 0.0 0.47 9.7 0.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Abhydrolase_6 PF12697.2 ESS66233.1 - 4.2e-28 98.7 0.0 8e-28 97.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS66233.1 - 1.5e-21 77.0 0.2 5.2e-21 75.2 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESS66233.1 - 2.6e-15 56.4 0.0 4.6e-14 52.4 0.0 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 ESS66233.1 - 1.3e-05 25.0 0.0 2.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein DLH PF01738.13 ESS66233.1 - 0.00032 20.0 0.0 0.034 13.4 0.0 2.4 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 ESS66233.1 - 0.0047 16.4 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 ESS66233.1 - 0.0059 16.4 0.0 0.026 14.3 0.0 1.9 2 0 0 2 2 2 1 Putative lysophospholipase Ndr PF03096.9 ESS66233.1 - 0.0065 14.9 0.1 0.022 13.2 0.0 1.7 2 0 0 2 2 2 1 Ndr family DUF2048 PF09752.4 ESS66233.1 - 0.0091 14.9 0.3 0.059 12.2 0.2 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2048) LIP PF03583.9 ESS66233.1 - 0.048 12.8 0.0 0.97 8.5 0.0 2.5 3 0 0 3 3 3 0 Secretory lipase Abhydrolase_6 PF12697.2 ESS66234.1 - 4.6e-26 92.1 0.1 5.7e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS66234.1 - 1.7e-17 63.7 0.0 3e-17 62.9 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESS66234.1 - 1.7e-13 50.5 0.0 4.1e-13 49.3 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS66234.1 - 8.5e-05 21.8 0.0 0.002 17.3 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 ESS66234.1 - 0.00017 21.1 0.0 0.00088 18.7 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 ESS66234.1 - 0.0019 17.9 0.0 0.0058 16.4 0.0 1.8 2 0 0 2 2 2 1 Putative lysophospholipase Ndr PF03096.9 ESS66234.1 - 0.0023 16.4 0.0 0.0031 16.0 0.0 1.2 1 0 0 1 1 1 1 Ndr family FSH1 PF03959.8 ESS66234.1 - 0.0048 16.3 0.0 0.0089 15.4 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.5 ESS66234.1 - 0.021 14.7 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Esterase PF00756.15 ESS66234.1 - 0.042 13.2 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DLH PF01738.13 ESS66234.1 - 0.11 11.7 0.0 6.2 6.0 0.0 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 ESS66235.1 - 2.3e-26 93.0 0.0 3.4e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS66235.1 - 6.2e-19 68.4 0.1 4.7e-18 65.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESS66235.1 - 2e-15 56.8 0.0 3.2e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 ESS66235.1 - 0.0023 16.4 0.0 0.0036 15.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_4 PF08386.5 ESS66235.1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_2 PF02230.11 ESS66235.1 - 0.013 14.9 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.15 ESS66235.1 - 0.053 12.9 0.1 0.13 11.6 0.1 1.6 2 0 0 2 2 2 0 Putative esterase Abhydrolase_3 PF07859.8 ESS66235.1 - 0.069 12.7 0.1 1.2 8.6 0.1 2.5 2 1 0 2 2 2 0 alpha/beta hydrolase fold Thioesterase PF00975.15 ESS66235.1 - 0.073 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 ESS66235.1 - 0.13 11.7 0.1 0.22 11.1 0.1 1.2 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.3 ESS66235.1 - 0.15 11.8 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase PLAC8 PF04749.12 ESS66236.1 - 1.1e-06 29.2 9.5 1.7e-06 28.5 5.7 2.0 1 1 1 2 2 2 1 PLAC8 family Kinesin PF00225.18 ESS66239.1 - 6e-13 48.1 0.0 1.3e-06 27.3 0.0 2.5 2 0 0 2 2 2 2 Kinesin motor domain AAA_30 PF13604.1 ESS66239.1 - 0.32 10.5 5.6 1 8.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain UCH PF00443.24 ESS66240.1 - 3.6e-21 75.4 0.0 7.3e-21 74.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS66240.1 - 1.4e-07 31.3 0.1 2.8e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Sporozoite_P67 PF05642.6 ESS66240.1 - 0.017 12.9 4.5 0.013 13.3 0.7 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Kinesin PF00225.18 ESS66241.1 - 6e-86 288.1 0.0 1e-85 287.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Calpain_III PF01067.17 ESS66241.1 - 2.9e-28 98.3 0.1 8.5e-22 77.3 0.0 2.9 2 0 0 2 2 2 2 Calpain large subunit, domain III Arm PF00514.18 ESS66241.1 - 6.6e-08 32.0 0.2 0.073 12.9 0.0 5.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESS66241.1 - 0.0019 18.4 0.6 0.018 15.3 0.1 2.4 1 1 2 3 3 3 3 HEAT repeats V-ATPase_H_C PF11698.3 ESS66241.1 - 0.0063 16.4 0.0 0.056 13.3 0.0 2.5 2 1 1 3 3 3 1 V-ATPase subunit H CorA PF01544.13 ESS66241.1 - 0.038 13.0 2.1 0.24 10.3 0.0 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein NifU PF01106.12 ESS66241.1 - 0.15 11.8 0.2 0.36 10.6 0.1 1.7 1 0 0 1 1 1 0 NifU-like domain Atg14 PF10186.4 ESS66241.1 - 4.6 6.0 12.1 9.1 5.1 3.4 2.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Pox_A_type_inc PF04508.7 ESS66241.1 - 6.9 6.7 8.3 0.29 11.0 1.0 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat MatE PF01554.13 ESS66242.1 - 4.3e-39 133.7 26.7 6.1e-24 84.4 6.7 2.3 2 0 0 2 2 2 2 MatE WW PF00397.21 ESS66243.1 - 7.1e-08 32.1 0.1 1.5e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 WW domain PsaD PF02531.11 ESS66243.1 - 0.019 14.2 0.0 0.042 13.0 0.0 1.6 1 0 0 1 1 1 0 PsaD TrbI_Ftype PF09677.5 ESS66243.1 - 0.097 12.5 2.2 0.22 11.3 0.3 2.6 2 0 0 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) Baculo_PEP_C PF04513.7 ESS66243.1 - 1.2 8.9 5.3 47 3.7 0.2 3.2 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATG27 PF09451.5 ESS66244.1 - 0.58 9.3 2.2 0.49 9.5 0.7 1.4 1 1 0 1 1 1 0 Autophagy-related protein 27 FixQ PF05545.6 ESS66244.1 - 6 6.5 14.0 0.57 9.8 0.4 2.6 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ XRN_N PF03159.13 ESS66245.1 - 2.4e-62 210.4 0.0 1e-61 208.3 0.0 1.9 1 1 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus FA_desaturase PF00487.19 ESS66245.1 - 0.019 14.4 0.6 0.041 13.3 0.4 1.5 1 0 0 1 1 1 0 Fatty acid desaturase SpoIIE PF07228.7 ESS66245.1 - 0.077 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) RNA_replicase_B PF03431.8 ESS66245.1 - 0.081 11.1 0.1 0.18 9.9 0.1 1.5 1 0 0 1 1 1 0 RNA replicase, beta-chain UDPGP PF01704.13 ESS66246.1 - 6.1e-07 28.2 0.0 8.4e-07 27.8 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase SinI PF08671.5 ESS66246.1 - 0.12 11.7 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Anti-repressor SinI Metal_resist PF13801.1 ESS66247.1 - 0.0014 18.6 1.1 0.0014 18.6 0.8 2.9 2 1 0 2 2 2 1 Heavy-metal resistance Laminin_II PF06009.7 ESS66247.1 - 0.013 15.2 6.6 0.053 13.2 2.0 2.4 2 0 0 2 2 2 0 Laminin Domain II Phage_GP20 PF06810.6 ESS66247.1 - 0.17 11.2 1.7 0.33 10.3 1.2 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 NUDE_C PF04880.8 ESS66247.1 - 0.47 10.8 11.6 0.53 10.6 0.5 2.8 2 1 0 2 2 2 0 NUDE protein, C-terminal conserved region Lge1 PF11488.3 ESS66247.1 - 1.9 8.7 5.1 9.3 6.5 3.5 2.2 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 Kinetocho_Slk19 PF12709.2 ESS66247.1 - 10 6.3 8.1 9.5 6.3 2.1 2.7 2 0 0 2 2 2 0 Central kinetochore-associated DUF1183 PF06682.7 ESS66248.1 - 0.0011 18.6 0.1 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Na_H_Exchanger PF00999.16 ESS66249.1 - 1.7e-18 66.3 28.8 2.5e-18 65.7 19.9 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family AAA_18 PF13238.1 ESS66250.1 - 1.4e-08 35.0 0.0 5.7e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS66250.1 - 1.6e-06 28.9 0.0 2.6e-06 28.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS66250.1 - 6.4e-05 22.6 0.0 0.00014 21.5 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 ESS66250.1 - 0.00026 20.1 0.0 0.00041 19.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin RuvB_N PF05496.7 ESS66250.1 - 0.00096 18.2 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 ESS66250.1 - 0.001 19.2 0.0 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.5 ESS66250.1 - 0.0015 17.8 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.1 ESS66250.1 - 0.0025 17.8 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 ESS66250.1 - 0.0039 17.0 0.0 0.031 14.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS66250.1 - 0.011 14.7 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 ESS66250.1 - 0.013 15.6 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS66250.1 - 0.014 15.7 0.0 0.019 15.2 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 ESS66250.1 - 0.022 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESS66250.1 - 0.023 13.6 0.0 0.03 13.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.18 ESS66250.1 - 0.024 14.5 0.0 0.066 13.1 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase DnaB_C PF03796.10 ESS66250.1 - 0.031 13.1 0.0 0.038 12.8 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Sigma54_activ_2 PF14532.1 ESS66250.1 - 0.034 14.2 0.0 0.42 10.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.7 ESS66250.1 - 0.035 13.7 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ArgK PF03308.11 ESS66250.1 - 0.048 12.4 0.0 0.079 11.7 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_28 PF13521.1 ESS66250.1 - 0.049 13.6 0.1 0.087 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESS66250.1 - 0.054 12.8 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESS66250.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.17 ESS66250.1 - 0.066 12.0 0.0 0.098 11.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain FtsK_SpoIIIE PF01580.13 ESS66250.1 - 0.068 12.6 0.0 0.15 11.4 0.0 1.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF258 PF03193.11 ESS66250.1 - 0.072 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NTPase_1 PF03266.10 ESS66250.1 - 0.11 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 NTPase ATG16 PF08614.6 ESS66251.1 - 0.039 13.7 22.6 0.033 14.0 3.1 3.4 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) His_kinase PF06580.8 ESS66251.1 - 0.26 11.2 1.6 24 4.9 0.1 2.7 2 0 0 2 2 2 0 Histidine kinase SlyX PF04102.7 ESS66251.1 - 0.45 10.9 6.3 7 7.1 1.0 3.1 2 0 0 2 2 2 0 SlyX FliD_N PF02465.13 ESS66252.1 - 0.045 14.1 1.1 0.061 13.6 0.1 1.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3833 PF12915.2 ESS66252.1 - 0.078 12.2 1.0 0.12 11.6 0.2 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3833) BLOC1_2 PF10046.4 ESS66252.1 - 0.12 12.5 3.3 0.094 12.8 0.6 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 ESS66252.1 - 0.15 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Flagellin_N PF00669.15 ESS66252.1 - 0.22 11.2 2.8 0.21 11.3 1.1 1.5 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region Fib_alpha PF08702.5 ESS66252.1 - 0.51 10.4 6.0 0.2 11.8 1.4 2.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.7 ESS66252.1 - 0.68 9.6 7.1 0.17 11.6 2.8 1.5 2 0 0 2 2 2 0 Laminin Domain II Cortex-I_coil PF09304.5 ESS66252.1 - 0.74 9.8 20.4 0.74 9.8 4.4 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF724 PF05266.9 ESS66252.1 - 1.4 8.5 12.5 0.24 11.0 6.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FAM195 PF14799.1 ESS66252.1 - 3.3 7.6 6.4 9.9 6.0 0.7 2.3 2 0 0 2 2 2 0 FAM195 family Phlebovirus_NSM PF07246.6 ESS66252.1 - 5.5 6.0 8.2 5.5 6.0 5.2 1.3 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M ABC1 PF03109.11 ESS66252.1 - 6.5 6.7 7.5 2 8.3 1.9 2.2 1 1 1 2 2 2 0 ABC1 family ADIP PF11559.3 ESS66252.1 - 7.8 6.3 19.1 1.4 8.7 7.1 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_11 PF13414.1 ESS66255.1 - 4.6e-13 48.6 4.8 6.6e-08 32.0 0.0 4.5 2 1 2 4 4 4 2 TPR repeat TPR_2 PF07719.12 ESS66255.1 - 2e-09 36.6 7.6 0.058 13.3 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS66255.1 - 7e-08 32.0 0.1 0.00073 19.5 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66255.1 - 1.5e-07 31.3 8.8 0.31 11.8 0.0 6.2 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66255.1 - 2.1e-07 30.2 0.6 0.49 10.0 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_15 PF13429.1 ESS66255.1 - 0.00028 20.0 4.4 0.0014 17.7 0.1 3.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66255.1 - 0.0018 18.5 0.9 0.27 11.6 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66255.1 - 0.005 17.4 5.6 0.15 12.7 0.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESS66255.1 - 0.012 15.7 0.1 3.6 7.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66255.1 - 0.015 15.2 7.2 3.8 7.5 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS66255.1 - 0.031 14.1 2.8 0.044 13.6 0.3 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat GNAT_acetyltr_2 PF13718.1 ESS66257.1 - 1.2e-69 233.5 0.0 2.4e-69 232.5 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 ESS66257.1 - 8.9e-60 201.3 0.0 3.1e-59 199.5 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 ESS66257.1 - 7.5e-37 124.9 0.1 2.8e-36 123.0 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 ESS66257.1 - 2.5e-22 78.8 0.1 5.6e-22 77.7 0.1 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 ESS66257.1 - 0.014 15.4 0.0 0.062 13.4 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain WWE PF02825.15 ESS66257.1 - 0.2 11.1 0.0 0.48 9.8 0.0 1.6 1 0 0 1 1 1 0 WWE domain Oscp1 PF10188.4 ESS66258.1 - 2.6e-66 222.7 1.6 3.6e-66 222.2 1.1 1.2 1 0 0 1 1 1 1 Organic solute transport protein 1 eIF2A PF08662.6 ESS66260.1 - 6.1e-17 61.9 0.0 1.1e-15 57.9 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A FTH PF01827.22 ESS66260.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 FTH domain Lactonase PF10282.4 ESS66260.1 - 0.12 11.3 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller SH3_1 PF00018.23 ESS66261.1 - 0.16 11.4 0.7 0.4 10.1 0.0 1.9 2 0 0 2 2 2 0 SH3 domain Carn_acyltransf PF00755.15 ESS66262.1 - 2.9e-121 405.4 0.0 3.8e-121 405.0 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Macro PF01661.16 ESS66263.1 - 7.8e-34 116.1 0.0 1.3e-33 115.3 0.0 1.4 1 0 0 1 1 1 1 Macro domain Methyltransf_32 PF13679.1 ESS66264.1 - 4.5e-15 55.5 0.0 2.1e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.1 ESS66264.1 - 0.043 13.3 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF4404 PF14357.1 ESS66265.1 - 0.028 14.8 0.3 0.051 13.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Vir_act_alpha_C PF10400.4 ESS66265.1 - 0.79 10.1 4.7 0.2 12.0 0.7 1.8 2 0 0 2 2 2 0 Virulence activator alpha C-term TraL PF07178.6 ESS66266.1 - 0.11 12.5 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 TraL protein DUF2664 PF10867.3 ESS66266.1 - 0.63 10.6 8.0 0.72 10.5 1.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2664) CTP_transf_2 PF01467.21 ESS66268.1 - 7.1e-16 58.6 0.0 3.4e-15 56.4 0.0 2.3 1 1 0 1 1 1 1 Cytidylyltransferase ALO PF04030.9 ESS66269.1 - 8.6e-78 261.5 3.4 1.4e-75 254.2 1.4 2.2 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 ESS66269.1 - 3.1e-23 81.8 1.9 6.9e-23 80.6 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain SDA1 PF05285.7 ESS66270.1 - 3.6e-73 246.6 44.9 2e-36 125.8 26.6 3.0 3 0 0 3 3 3 2 SDA1 NUC130_3NT PF08158.7 ESS66270.1 - 1.4e-17 63.6 0.4 3.5e-17 62.4 0.3 1.8 1 0 0 1 1 1 1 NUC130/3NT domain IQ PF00612.22 ESS66271.1 - 1.3e-06 27.4 25.9 0.017 14.7 2.9 4.7 3 1 0 3 3 3 3 IQ calmodulin-binding motif Inositol_P PF00459.20 ESS66272.1 - 4e-65 219.8 0.2 5e-65 219.4 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Peptidase_C65 PF10275.4 ESS66273.1 - 7.2e-65 218.7 0.0 8.1e-65 218.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.14 ESS66273.1 - 2.6e-07 31.2 0.0 3.6e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 OTU-like cysteine protease GP41 PF00517.12 ESS66274.1 - 0.0071 15.9 0.7 0.031 13.8 0.5 2.1 1 0 0 1 1 1 1 Retroviral envelope protein DUF3538 PF12057.3 ESS66274.1 - 0.0074 15.8 0.5 0.03 13.9 0.3 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3538) DUF3357 PF11837.3 ESS66276.1 - 3.5 7.5 5.2 1.8 8.4 0.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) zf-ZPR1 PF03367.8 ESS66277.1 - 3.3e-104 344.9 0.1 1.6e-52 176.9 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain DUF2387 PF09526.5 ESS66277.1 - 0.0012 18.7 0.9 1.3 8.9 0.0 3.0 2 0 0 2 2 2 2 Probable metal-binding protein (DUF2387) Cys_rich_KTR PF14205.1 ESS66277.1 - 0.0094 15.3 0.8 0.28 10.6 0.0 2.6 2 0 0 2 2 2 1 Cysteine-rich KTR Zn-ribbon_8 PF09723.5 ESS66277.1 - 0.021 14.7 8.0 7.7 6.5 0.0 4.4 4 0 0 4 4 4 0 Zinc ribbon domain HypA PF01155.14 ESS66277.1 - 0.042 13.5 2.9 3.7 7.2 0.1 2.7 2 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF4451 PF14616.1 ESS66277.1 - 0.042 13.6 0.2 4.2 7.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4451) DnaJ_CXXCXGXG PF00684.14 ESS66277.1 - 0.24 11.4 4.6 2.4 8.2 0.4 2.6 2 0 0 2 2 2 0 DnaJ central domain Zn_Tnp_IS1595 PF12760.2 ESS66277.1 - 0.27 11.0 5.6 2.6 7.9 0.6 3.0 2 2 1 3 3 3 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.1 ESS66277.1 - 0.41 9.9 11.1 18 4.7 0.1 4.3 4 0 0 4 4 4 0 zinc-ribbon domain Elf1 PF05129.8 ESS66277.1 - 1.1 8.9 8.0 14 5.4 0.5 3.2 2 2 0 2 2 2 0 Transcription elongation factor Elf1 like UPF0547 PF10571.4 ESS66277.1 - 3.7 7.3 12.6 12 5.6 0.1 4.0 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 DZR PF12773.2 ESS66277.1 - 6.9 6.5 10.3 31 4.4 1.2 3.4 2 2 1 3 3 3 0 Double zinc ribbon Uteroglobin PF01099.12 ESS66278.1 - 0.089 12.5 2.1 0.11 12.3 0.3 2.0 2 0 0 2 2 2 0 Uteroglobin family Spc7 PF08317.6 ESS66278.1 - 0.2 10.2 24.8 0.024 13.2 13.2 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF342 PF03961.8 ESS66278.1 - 0.8 8.0 14.0 0.19 10.1 6.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Lectin_N PF03954.9 ESS66278.1 - 1 8.7 8.7 1.5 8.2 0.7 3.1 1 1 1 3 3 3 0 Hepatic lectin, N-terminal domain GAGA_bind PF06217.7 ESS66278.1 - 1.3 8.9 9.9 0.27 11.1 4.0 1.8 1 1 1 2 2 2 0 GAGA binding protein-like family DUF745 PF05335.8 ESS66278.1 - 8.7 5.8 12.2 3.3 7.1 3.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) KxDL PF10241.4 ESS66278.1 - 9.2 6.2 12.0 3.1 7.7 0.8 3.1 1 1 1 3 3 3 0 Uncharacterized conserved protein BRE1 PF08647.6 ESS66278.1 - 9.4 6.2 20.0 1 9.3 8.7 2.8 1 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase RabGAP-TBC PF00566.13 ESS66279.1 - 2.4e-17 63.1 1.0 4.1e-17 62.3 0.7 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Abhydrolase_6 PF12697.2 ESS66280.1 - 2.9e-14 53.5 0.1 4.2e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS66280.1 - 9.7e-07 28.6 0.0 2.1e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS66280.1 - 0.00011 21.7 0.0 0.00089 18.8 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESS66280.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Nol1_Nop2_Fmu PF01189.12 ESS66282.1 - 8e-24 84.4 0.0 8.3e-23 81.1 0.0 2.4 3 0 0 3 3 3 1 NOL1/NOP2/sun family FtsJ PF01728.14 ESS66282.1 - 0.065 13.2 0.0 0.18 11.8 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase Cyt-b5 PF00173.23 ESS66283.1 - 3.8e-18 65.0 0.0 8.2e-18 63.9 0.0 1.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF4459 PF14673.1 ESS66283.1 - 0.077 12.6 0.0 0.092 12.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4459) PqqA PF08042.6 ESS66294.1 - 0.1 12.3 0.0 0.3 10.8 0.0 1.8 1 0 0 1 1 1 0 PqqA family Sec63 PF02889.11 ESS66296.1 - 2.9e-40 138.4 0.0 6.4e-40 137.3 0.0 1.4 1 1 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 ESS66296.1 - 1.8e-24 86.1 0.0 2.9e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS66296.1 - 5.6e-07 29.3 0.0 1.5e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS66296.1 - 1.1e-05 25.2 0.0 2.2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 ESS66296.1 - 0.00086 18.2 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein HHH_5 PF14520.1 ESS66296.1 - 0.04 14.0 0.1 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 ESS66296.1 - 0.055 13.0 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda AAA_19 PF13245.1 ESS66296.1 - 0.083 12.6 0.0 0.26 11.0 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain UvrD-helicase PF00580.16 ESS66296.1 - 0.12 11.7 0.0 0.79 8.9 0.0 2.0 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PI3_PI4_kinase PF00454.22 ESS66299.1 - 4.1e-39 134.4 0.1 1e-38 133.1 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESS66299.1 - 1.3e-15 57.2 6.8 9.3e-14 51.1 0.7 3.2 1 1 1 2 2 2 1 FAT domain FATC PF02260.15 ESS66299.1 - 8.8e-13 47.4 1.0 2.3e-12 46.1 0.7 1.7 1 0 0 1 1 1 1 FATC domain UME PF08064.8 ESS66299.1 - 0.00089 19.1 0.1 0.0054 16.6 0.0 2.4 1 0 0 1 1 1 1 UME (NUC010) domain MIP-T3 PF10243.4 ESS66300.1 - 1.4e-12 46.9 3.9 1.4e-12 46.9 2.7 2.2 2 1 0 2 2 2 1 Microtubule-binding protein MIP-T3 DUF3752 PF12572.3 ESS66300.1 - 0.09 12.8 2.0 0.19 11.8 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) Peptidase_M41 PF01434.13 ESS66303.1 - 4.2e-54 183.2 0.6 7.6e-54 182.4 0.4 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESS66303.1 - 1.2e-40 138.7 0.0 3.6e-40 137.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS66303.1 - 0.00039 20.4 0.4 0.0028 17.6 0.3 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESS66303.1 - 0.0011 19.1 0.6 0.0066 16.5 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS66303.1 - 0.0013 18.4 0.4 0.0044 16.7 0.3 1.9 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 ESS66303.1 - 0.0024 16.9 0.0 0.0093 15.0 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESS66303.1 - 0.0082 15.5 1.2 0.057 12.8 0.3 2.3 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESS66303.1 - 0.015 14.7 0.2 0.034 13.5 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.9 ESS66303.1 - 0.024 14.3 0.4 0.22 11.2 0.3 2.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESS66303.1 - 0.033 14.0 0.0 0.078 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESS66303.1 - 0.038 13.4 0.0 0.27 10.6 0.0 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.8 ESS66303.1 - 0.048 12.3 0.0 0.12 11.0 0.0 1.6 2 0 0 2 2 2 0 TIP49 C-terminus AAA_17 PF13207.1 ESS66303.1 - 0.049 14.4 0.1 0.18 12.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESS66303.1 - 0.051 12.5 0.1 0.098 11.6 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 ESS66303.1 - 0.082 12.5 0.1 0.94 9.1 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Sigma54_activ_2 PF14532.1 ESS66303.1 - 0.089 12.8 0.1 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 ESS66303.1 - 0.12 12.7 0.0 0.39 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Peptidase_M50B PF13398.1 ESS66303.1 - 0.17 11.2 0.0 0.38 10.1 0.0 1.5 1 0 0 1 1 1 0 Peptidase M50B-like AAA_2 PF07724.9 ESS66303.1 - 0.18 11.6 2.5 0.97 9.3 0.4 3.1 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) YqaJ PF09588.5 ESS66305.1 - 1.4e-40 138.7 0.0 2.1e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain PSP1 PF04468.7 ESS66307.1 - 4.1e-26 90.7 1.2 5.2e-26 90.4 0.2 1.7 2 0 0 2 2 2 1 PSP1 C-terminal conserved region NPV_P10 PF05531.7 ESS66307.1 - 0.11 12.8 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein CLU PF13236.1 ESS66308.1 - 4e-21 75.4 0.0 6.3e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 ESS66308.1 - 4.5e-05 23.4 0.0 9.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 ArfGap PF01412.13 ESS66310.1 - 1e-39 134.9 0.2 1.6e-39 134.2 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PMI_typeI PF01238.16 ESS66311.1 - 2.6e-84 283.3 0.0 6.2e-84 282.1 0.0 1.6 1 1 0 1 1 1 1 Phosphomannose isomerase type I PIF1 PF05970.9 ESS66312.1 - 1.6e-10 40.4 0.3 0.00071 18.6 0.1 3.1 3 0 0 3 3 3 2 PIF1-like helicase AAA_16 PF13191.1 ESS66312.1 - 0.00094 19.2 0.1 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.1 ESS66312.1 - 0.0034 16.9 0.1 0.0077 15.8 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS66312.1 - 0.0072 16.0 0.0 0.021 14.5 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 ESS66312.1 - 0.031 13.9 0.1 0.23 11.1 0.0 2.3 2 0 0 2 2 2 0 NACHT domain Nup54 PF13874.1 ESS66312.1 - 0.05 13.2 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 AAA_25 PF13481.1 ESS66312.1 - 0.077 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESS66312.1 - 0.093 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESS66312.1 - 0.12 11.2 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) 5_3_exonuc_N PF02739.11 ESS66314.1 - 0.015 14.6 0.0 0.033 13.5 0.0 1.5 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF2000 PF09391.5 ESS66314.1 - 0.094 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) Herpes_LP PF03363.8 ESS66316.1 - 0.038 13.5 0.7 0.058 12.9 0.5 1.3 1 0 0 1 1 1 0 Herpesvirus leader protein SPACA7 PF15307.1 ESS66316.1 - 4.4 7.4 6.7 2.1 8.4 0.8 2.2 2 0 0 2 2 2 0 Sperm acrosome-associated protein 7 HSA PF07529.8 ESS66317.1 - 1.5 8.6 4.3 13 5.6 0.0 2.7 3 0 0 3 3 3 0 HSA NAD_synthase PF02540.12 ESS66320.1 - 3.8e-34 117.6 0.0 4.7e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 ESS66320.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase PAPS_reduct PF01507.14 ESS66320.1 - 0.094 12.5 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DNA_pol_E_B PF04042.11 ESS66321.1 - 2.9e-12 46.3 0.0 6.3e-12 45.1 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Coatomer_E PF04733.9 ESS66322.1 - 5.3e-33 114.4 4.2 7.5e-32 110.6 2.9 2.1 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_11 PF13414.1 ESS66322.1 - 2.8e-07 30.0 0.5 0.0004 19.9 0.0 4.0 3 2 1 4 4 4 2 TPR repeat TPR_19 PF14559.1 ESS66322.1 - 3.2e-07 30.5 9.6 0.0001 22.5 0.0 4.0 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66322.1 - 5.7e-07 29.3 3.9 0.00039 20.3 0.1 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66322.1 - 0.013 16.0 18.8 0.039 14.5 0.1 5.9 5 3 3 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66322.1 - 0.018 15.6 18.4 0.93 10.2 0.1 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat YqeY PF09424.5 ESS66322.1 - 0.025 14.4 0.8 0.089 12.6 0.2 2.0 2 0 0 2 2 2 0 Yqey-like protein TPR_1 PF00515.23 ESS66322.1 - 0.027 14.0 0.4 1.5 8.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66322.1 - 0.051 13.5 7.9 0.3 11.0 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS66322.1 - 0.21 11.8 2.3 39 4.8 0.0 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS66322.1 - 0.23 11.3 4.9 3.5 7.6 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Mito_carr PF00153.22 ESS66323.1 - 1.5e-58 194.5 4.2 1.4e-21 75.9 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein PP2C PF00481.16 ESS66325.1 - 2.8e-71 239.9 0.0 3.6e-71 239.5 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESS66325.1 - 0.004 16.6 0.0 0.0087 15.4 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C DUF2717 PF10911.3 ESS66328.1 - 0.15 11.5 0.0 0.44 10.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) SpoU_methylase PF00588.14 ESS66329.1 - 2.8e-07 30.5 0.1 2.8e-05 24.0 0.0 2.9 2 1 0 2 2 2 2 SpoU rRNA Methylase family Presenilin PF01080.12 ESS66330.1 - 2.7 6.7 5.5 2.9 6.6 3.8 1.1 1 0 0 1 1 1 0 Presenilin Spt5_N PF11942.3 ESS66330.1 - 7.1 7.3 13.1 3.9e+02 1.7 9.1 2.1 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PUF PF00806.14 ESS66331.1 - 3.2e-21 73.5 0.0 0.0011 18.3 0.0 7.8 9 0 0 9 9 9 5 Pumilio-family RNA binding repeat Vfa1 PF08432.5 ESS66331.1 - 0.0029 17.6 3.6 0.007 16.4 2.5 1.6 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF1414 PF07208.6 ESS66331.1 - 0.0075 15.9 0.0 0.046 13.4 0.0 2.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1414) RXT2_N PF08595.6 ESS66331.1 - 0.013 15.2 1.3 0.05 13.4 0.9 1.9 1 0 0 1 1 1 0 RXT2-like, N-terminal Rrn6 PF10214.4 ESS66332.1 - 0.025 12.6 0.4 0.036 12.1 0.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Homez PF11569.3 ESS66332.1 - 0.055 12.5 0.1 1.7 7.7 0.0 2.5 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez PBP PF01161.15 ESS66333.1 - 3.1e-07 30.3 0.0 5.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Pkinase PF00069.20 ESS66336.1 - 1.3e-51 175.2 0.0 1.5e-50 171.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66336.1 - 1.8e-28 99.3 0.0 6.5e-28 97.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 ESS66336.1 - 3.7e-05 23.8 0.0 7.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 ESS66336.1 - 0.0003 19.8 0.0 0.00047 19.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PH_4 PF15404.1 ESS66336.1 - 0.003 17.1 0.0 0.096 12.2 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.1 ESS66336.1 - 0.0036 17.4 0.0 0.0078 16.3 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 ESS66336.1 - 0.1 12.8 0.0 0.36 11.0 0.0 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain Cpn60_TCP1 PF00118.19 ESS66337.1 - 2.4e-54 184.7 1.5 2.6e-54 184.6 1.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3586 PF12131.3 ESS66337.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3586) Cpn60_TCP1 PF00118.19 ESS66338.1 - 4.9e-52 177.1 0.0 6e-52 176.8 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cation_efflux PF01545.16 ESS66341.1 - 3e-08 33.0 12.4 8.5e-08 31.6 8.6 1.9 1 1 0 1 1 1 1 Cation efflux family SpoU_methylase PF00588.14 ESS66350.1 - 5.2e-15 55.5 0.0 4.9e-07 29.7 0.0 3.2 2 1 1 3 3 3 2 SpoU rRNA Methylase family Rxt3 PF08642.5 ESS66350.1 - 0.14 12.4 0.1 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Abhydrolase_5 PF12695.2 ESS66353.1 - 4.5e-14 52.4 0.0 7.7e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS66353.1 - 4.6e-08 33.2 0.0 8.8e-06 25.7 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS66353.1 - 1.7e-06 27.3 0.0 3.7e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 ESS66353.1 - 2.1e-06 27.4 0.0 3.8e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 ESS66353.1 - 0.012 14.9 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Thioesterase PF00975.15 ESS66353.1 - 0.12 12.6 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain Vps39_2 PF10367.4 ESS66354.1 - 5.2e-21 74.8 0.4 2.1e-20 72.9 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.4 ESS66354.1 - 2.3e-20 72.5 5.9 1.2e-18 67.0 0.4 2.9 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 CNH PF00780.17 ESS66354.1 - 2e-13 50.4 0.0 4.3e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.15 ESS66354.1 - 3.8e-08 33.0 4.4 1.6e-06 27.7 0.4 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS FAM91_N PF14647.1 ESS66355.1 - 1.8e-118 395.1 0.3 2.3e-118 394.7 0.2 1.1 1 0 0 1 1 1 1 FAM91 N-terminus FAM91_C PF14648.1 ESS66355.1 - 7.5e-117 390.9 0.6 1.3e-116 390.0 0.4 1.3 1 0 0 1 1 1 1 FAM91 C-terminus SET PF00856.23 ESS66356.1 - 6.7e-09 36.2 0.0 1.3e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.13 ESS66356.1 - 0.0065 16.3 12.0 0.0065 16.3 8.3 2.7 2 0 0 2 2 2 1 MYND finger TPR_11 PF13414.1 ESS66356.1 - 0.066 12.8 1.8 1.1 8.9 0.1 2.9 1 1 2 3 3 3 0 TPR repeat Tubulin_C PF03953.12 ESS66356.1 - 0.067 13.2 0.0 0.87 9.6 0.0 2.2 2 0 0 2 2 2 0 Tubulin C-terminal domain Nucleoplasmin PF03066.10 ESS66357.1 - 0.0055 16.2 1.1 0.0059 16.1 0.7 1.1 1 0 0 1 1 1 1 Nucleoplasmin IFT57 PF10498.4 ESS66357.1 - 0.021 13.5 0.2 0.024 13.4 0.1 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 RXT2_N PF08595.6 ESS66357.1 - 0.026 14.3 0.6 0.031 14.0 0.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.1 ESS66357.1 - 0.14 11.8 2.3 0.16 11.6 1.6 1.1 1 0 0 1 1 1 0 FAM176 family Ribosomal_60s PF00428.14 ESS66357.1 - 1.1 9.7 5.7 2 8.9 3.9 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein PBP1_TM PF14812.1 ESS66357.1 - 1.9 8.8 10.3 2.9 8.2 7.1 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Methyltransf_31 PF13847.1 ESS66359.1 - 2.5e-14 53.1 0.8 5e-14 52.1 0.6 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESS66359.1 - 2.4e-12 46.5 0.0 4.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 ESS66359.1 - 4.9e-11 43.1 0.0 9.8e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS66359.1 - 3.5e-09 36.7 0.0 6.4e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 ESS66359.1 - 7.3e-09 35.0 0.0 8.4e-09 34.8 0.0 1.0 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_11 PF08241.7 ESS66359.1 - 8.4e-09 35.8 0.1 3e-08 34.0 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS66359.1 - 3.4e-08 33.3 0.0 6.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS66359.1 - 5e-08 32.5 0.2 8.1e-08 31.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESS66359.1 - 4.5e-07 30.1 0.0 9e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESS66359.1 - 1.5e-06 27.4 0.1 2.7e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.6 ESS66359.1 - 4.3e-06 25.6 0.1 6.4e-06 25.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.7 ESS66359.1 - 6.3e-06 26.5 0.0 1.3e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESS66359.1 - 8.7e-05 21.7 0.1 0.00017 20.8 0.1 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Met_10 PF02475.11 ESS66359.1 - 0.0021 17.7 0.0 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.14 ESS66359.1 - 0.0022 17.5 0.1 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 ESS66359.1 - 0.0025 16.9 0.1 0.004 16.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 ESS66359.1 - 0.0038 17.2 0.0 0.0064 16.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.1 ESS66359.1 - 0.0055 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESS66359.1 - 0.026 13.5 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_24 PF13578.1 ESS66359.1 - 0.034 14.9 0.0 0.078 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 ESS66359.1 - 0.14 11.5 0.0 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein 95 F-box PF00646.28 ESS66363.1 - 0.02 14.5 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 F-box domain Anthrax-tox_M PF09156.5 ESS66363.1 - 0.03 13.4 0.1 0.052 12.6 0.0 1.3 1 0 0 1 1 1 0 Anthrax toxin lethal factor, middle domain Peptidase_M1 PF01433.15 ESS66364.1 - 5.7e-61 206.7 0.0 5.3e-44 150.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M1 Peptidase_MA_2 PF13485.1 ESS66364.1 - 8.7e-07 29.0 0.0 2.9e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase MA superfamily Crust_neurohorm PF01147.12 ESS66364.1 - 0.0082 15.4 0.2 0.027 13.7 0.1 1.9 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family zf-C3HC4_2 PF13923.1 ESS66365.1 - 7.1e-07 29.1 14.5 1.6e-06 28.0 10.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS66365.1 - 2.3e-06 27.1 14.1 5.7e-06 25.8 9.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS66365.1 - 0.00031 20.3 13.2 0.00071 19.2 9.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESS66365.1 - 0.00033 20.4 13.5 0.00093 18.9 9.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 ESS66365.1 - 0.078 12.8 14.4 0.22 11.4 10.0 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESS66365.1 - 0.14 11.9 8.5 0.43 10.3 5.9 2.0 1 0 0 1 1 1 0 RING-type zinc-finger DUF4546 PF15079.1 ESS66365.1 - 0.24 10.5 4.1 0.1 11.7 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4546) BRO1 PF03097.13 ESS66366.1 - 0.014 14.1 0.7 0.014 14.1 0.5 2.4 2 1 1 3 3 3 0 BRO1-like domain AAA_13 PF13166.1 ESS66366.1 - 0.026 12.9 10.7 0.0068 14.9 5.4 1.5 2 0 0 2 2 2 0 AAA domain HALZ PF02183.13 ESS66366.1 - 0.034 13.8 0.6 0.034 13.8 0.4 3.4 4 1 0 4 4 4 0 Homeobox associated leucine zipper DUF2408 PF10303.4 ESS66366.1 - 0.062 13.4 14.8 0.028 14.5 7.9 2.2 2 1 0 2 2 1 0 Protein of unknown function (DUF2408) DUF2935 PF11155.3 ESS66366.1 - 0.066 13.2 4.7 0.065 13.3 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) Syntaxin PF00804.20 ESS66366.1 - 0.16 12.1 16.7 0.041 14.0 3.0 3.4 2 1 1 3 3 3 0 Syntaxin ATG16 PF08614.6 ESS66366.1 - 0.39 10.5 22.4 0.64 9.8 1.7 2.8 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) GAS PF13851.1 ESS66366.1 - 0.49 9.5 23.5 0.062 12.4 11.5 2.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 ESS66366.1 - 0.94 9.0 32.4 1.6 8.2 9.9 2.9 2 1 1 3 3 3 0 IncA protein Atg14 PF10186.4 ESS66366.1 - 1.4 7.7 22.1 0.35 9.7 12.5 1.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TMF_DNA_bd PF12329.3 ESS66366.1 - 1.9 8.3 18.3 0.064 13.0 0.6 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding ALIX_LYPXL_bnd PF13949.1 ESS66366.1 - 2.2 7.1 23.5 5.1 5.9 12.7 2.9 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV Bacillus_HBL PF05791.6 ESS66366.1 - 2.4 7.4 11.7 2.7 7.3 0.2 2.9 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Baculo_PEP_C PF04513.7 ESS66366.1 - 3.2 7.5 5.7 19 5.0 0.1 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TBPIP PF07106.8 ESS66366.1 - 6.7 6.2 19.2 0.25 10.8 4.0 2.8 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1664 PF07889.7 ESS66366.1 - 7.2 6.4 14.6 6.1 6.6 1.5 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Spc7 PF08317.6 ESS66366.1 - 8.1 5.0 22.9 3 6.4 7.2 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein TSC22 PF01166.13 ESS66366.1 - 8.2 6.4 16.1 2.8 7.9 4.0 3.3 1 1 1 2 2 2 0 TSC-22/dip/bun family SNARE_assoc PF09335.6 ESS66367.1 - 3.8e-19 69.0 6.7 3.8e-19 69.0 4.6 3.0 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF3639 PF12341.3 ESS66369.1 - 4.7e-05 23.2 1.3 0.00018 21.4 0.9 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3639) WD40 PF00400.27 ESS66369.1 - 0.0004 20.1 1.3 0.072 12.9 0.1 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat PEP-utilisers_N PF05524.8 ESS66370.1 - 0.14 11.9 1.8 0.16 11.7 0.3 1.8 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal BK_channel_a PF03493.13 ESS66371.1 - 1e-17 63.8 0.0 2.6e-17 62.6 0.0 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.11 ESS66371.1 - 2.5e-09 36.7 8.4 2.5e-09 36.7 5.8 2.7 2 0 0 2 2 2 1 Ion channel POTRA_2 PF08479.6 ESS66371.1 - 0.16 11.6 0.0 0.42 10.3 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, ShlB-type ABC_tran PF00005.22 ESS66372.1 - 1.4e-14 54.5 0.0 5.5e-14 52.6 0.0 2.0 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 ESS66372.1 - 1e-05 25.6 0.1 1e-05 25.6 0.1 2.4 3 0 0 3 3 2 1 AAA ATPase domain AAA_21 PF13304.1 ESS66372.1 - 2.5e-05 24.4 0.0 0.04 13.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ESS66372.1 - 5.5e-05 23.9 1.3 0.00064 20.5 0.0 3.2 3 1 0 3 3 2 1 AAA domain AAA_22 PF13401.1 ESS66372.1 - 0.00014 22.0 0.0 0.00091 19.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS66372.1 - 0.00019 21.1 4.1 0.00041 20.0 0.0 3.2 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 ESS66372.1 - 0.0011 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS66372.1 - 0.0014 18.3 0.3 0.0072 16.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.7 ESS66372.1 - 0.0018 17.9 0.0 0.0083 15.7 0.0 2.2 1 0 0 1 1 1 1 NACHT domain DUF258 PF03193.11 ESS66372.1 - 0.002 17.3 0.0 0.0036 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 ESS66372.1 - 0.0023 18.2 0.0 0.0072 16.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.1 ESS66372.1 - 0.0048 16.8 0.4 0.017 15.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS66372.1 - 0.0079 15.1 0.1 0.046 12.6 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein Rad17 PF03215.10 ESS66372.1 - 0.0099 14.6 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein SMC_N PF02463.14 ESS66372.1 - 0.017 14.3 0.0 0.76 8.9 0.0 2.4 3 0 0 3 3 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESS66372.1 - 0.018 15.4 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESS66372.1 - 0.024 14.0 0.2 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESS66372.1 - 0.032 14.4 0.0 0.1 12.8 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 ESS66372.1 - 0.034 13.8 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase PRK PF00485.13 ESS66372.1 - 0.037 13.5 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 ESS66372.1 - 0.064 13.1 0.1 0.34 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESS66372.1 - 0.078 12.5 0.1 0.2 11.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 ESS66372.1 - 0.08 12.3 0.2 0.47 9.8 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_35 PF14516.1 ESS66372.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain NTPase_1 PF03266.10 ESS66372.1 - 0.12 12.1 0.0 0.33 10.6 0.0 1.8 1 0 0 1 1 1 0 NTPase Viral_helicase1 PF01443.13 ESS66372.1 - 0.18 11.2 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF4498 PF14926.1 ESS66372.1 - 0.21 10.6 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4498) MobB PF03205.9 ESS66372.1 - 0.21 11.2 0.0 0.43 10.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF308 PF03729.8 ESS66372.1 - 3.2 7.8 7.6 6.2 6.8 0.1 2.8 3 0 0 3 3 2 0 Short repeat of unknown function (DUF308) OB_RNB PF08206.6 ESS66373.1 - 0.00089 18.7 0.3 0.003 17.0 0.2 2.0 1 0 0 1 1 1 1 Ribonuclease B OB domain CSD PF00313.17 ESS66373.1 - 0.0024 17.6 0.0 0.01 15.5 0.0 2.1 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain AF2331-like PF14556.1 ESS66373.1 - 0.092 13.0 0.6 0.2 12.0 0.4 1.4 1 0 0 1 1 1 0 AF2331-like CDC45 PF02724.9 ESS66373.1 - 2.1 6.2 13.2 2.8 5.8 6.3 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF2404 PF10296.4 ESS66374.1 - 2.8e-22 78.6 0.0 5.5e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) 7tm_6 PF02949.15 ESS66375.1 - 0.96 8.2 8.6 1.1 8.0 6.0 1.1 1 0 0 1 1 1 0 7tm Odorant receptor DUF2404 PF10296.4 ESS66376.1 - 1.9e-22 79.2 0.0 3.3e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) FAM198 PF15051.1 ESS66378.1 - 0.019 13.6 0.0 0.03 13.0 0.0 1.2 1 0 0 1 1 1 0 FAM198 protein DnaJ PF00226.26 ESS66381.1 - 1.1e-17 63.4 0.0 2.5e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain zf-C3HC4_3 PF13920.1 ESS66381.1 - 0.0053 16.4 14.1 0.0092 15.6 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vfa1 PF08432.5 ESS66381.1 - 0.013 15.5 0.5 0.013 15.5 0.3 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 LRR_6 PF13516.1 ESS66385.1 - 4.7e-17 60.0 16.9 0.029 14.4 0.0 11.3 12 0 0 12 12 12 5 Leucine Rich repeat LRR_4 PF12799.2 ESS66385.1 - 4.5e-05 22.9 11.8 7.4 6.3 0.0 7.6 4 3 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS66385.1 - 0.00029 20.5 14.1 5.2 6.9 0.2 7.2 6 2 0 6 6 6 2 Leucine rich repeat LRR_1 PF00560.28 ESS66385.1 - 0.0006 19.4 10.8 53 4.4 0.0 8.6 8 2 0 8 8 8 0 Leucine Rich Repeat DUF1448 PF07289.6 ESS66387.1 - 2.3e-134 447.6 0.0 2.6e-134 447.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1448) Vps36_ESCRT-II PF11605.3 ESS66387.1 - 0.0051 16.5 0.0 0.63 9.8 0.0 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 Voldacs PF03517.8 ESS66387.1 - 0.15 11.9 0.0 8.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling Pkinase PF00069.20 ESS66388.1 - 7.6e-63 212.0 0.0 9.2e-63 211.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66388.1 - 3.9e-41 140.8 0.0 4.9e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS66388.1 - 1.1e-09 37.6 0.0 1.5e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESS66388.1 - 0.00019 21.2 1.9 0.00037 20.3 0.2 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS66388.1 - 0.017 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ESS66388.1 - 0.039 12.8 0.0 0.058 12.2 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.17 ESS66388.1 - 0.06 12.6 0.1 0.22 10.8 0.1 1.8 1 1 0 1 1 1 0 RIO1 family ESCRT-II PF05871.7 ESS66389.1 - 1.2 9.0 4.5 0.49 10.3 0.1 2.5 2 1 0 2 2 2 0 ESCRT-II complex subunit Metallophos PF00149.23 ESS66393.1 - 2.7e-37 128.1 0.2 7.6e-37 126.6 0.1 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase zf-TRAF PF02176.13 ESS66393.1 - 0.0006 20.1 4.8 0.0006 20.1 3.3 2.1 1 1 1 2 2 2 1 TRAF-type zinc finger Metallophos_2 PF12850.2 ESS66393.1 - 0.0017 18.1 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RLI PF04068.10 ESS66393.1 - 0.034 13.7 1.0 0.069 12.7 0.7 1.5 1 0 0 1 1 1 0 Possible Fer4-like domain in RNase L inhibitor, RLI zf-ribbon_3 PF13248.1 ESS66393.1 - 2 7.7 6.6 7.6 5.8 0.0 3.5 3 0 0 3 3 3 0 zinc-ribbon domain DUF2197 PF09963.4 ESS66394.1 - 0.0081 16.0 1.0 0.027 14.4 0.7 1.8 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2197) PriCT_2 PF08707.6 ESS66396.1 - 1.5e-16 59.9 0.2 3.2e-16 58.9 0.1 1.5 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) CTNNB1_binding PF08347.6 ESS66396.1 - 0.014 15.6 0.7 0.014 15.6 0.5 2.2 2 0 0 2 2 2 0 N-terminal CTNNB1 binding Nop53 PF07767.6 ESS66396.1 - 0.018 14.0 18.4 0.15 11.0 3.9 2.3 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Myc_N PF01056.13 ESS66396.1 - 1.6 7.7 13.4 0.46 9.6 1.3 2.4 2 0 0 2 2 2 0 Myc amino-terminal region Spt5_N PF11942.3 ESS66396.1 - 1.7 9.2 23.0 5.6 7.6 4.3 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Lin-8 PF03353.10 ESS66396.1 - 5.8 6.0 12.1 0.3 10.3 2.7 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Aminotran_1_2 PF00155.16 ESS66397.1 - 4e-32 111.5 0.0 5.3e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II TPR_11 PF13414.1 ESS66399.1 - 3.7e-17 61.7 12.2 2.9e-08 33.2 1.9 6.0 3 1 2 6 6 6 4 TPR repeat TPR_2 PF07719.12 ESS66399.1 - 3.2e-14 51.6 24.3 0.00015 21.4 0.2 8.8 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66399.1 - 3.1e-13 49.0 9.3 1.4e-05 25.2 0.8 7.3 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66399.1 - 3.6e-13 48.4 11.0 4.8e-05 22.7 0.0 7.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESS66399.1 - 1.3e-12 46.4 6.5 2.9e-05 23.5 0.0 6.3 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS66399.1 - 4.4e-11 42.0 6.0 0.014 15.4 0.1 5.6 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66399.1 - 3.7e-10 40.2 15.3 8.2e-06 26.3 1.1 6.1 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66399.1 - 2.9e-08 33.5 23.5 0.03 14.2 0.2 7.4 4 1 3 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66399.1 - 4.2e-08 33.4 2.9 0.01 16.1 0.1 5.2 3 2 2 5 5 5 2 Tetratricopeptide repeat APC8 PF04049.8 ESS66399.1 - 0.00014 21.5 0.0 0.00033 20.3 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_15 PF13429.1 ESS66399.1 - 0.00028 20.0 0.7 0.00079 18.5 0.5 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS66399.1 - 0.00051 20.1 7.5 3.4 7.8 0.2 5.5 3 1 4 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESS66399.1 - 0.023 14.5 0.7 0.023 14.5 0.5 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS66399.1 - 0.43 10.5 18.1 0.11 12.3 0.2 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS66399.1 - 0.7 10.4 14.7 1.1 9.9 0.1 6.5 9 0 0 9 9 6 0 Tetratricopeptide repeat BTAD PF03704.12 ESS66399.1 - 1.8 8.8 9.1 6 7.1 0.2 3.5 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.1 ESS66399.1 - 2.4 8.2 17.4 0.78 9.7 0.1 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Sulfatase PF00884.18 ESS66400.1 - 0.00012 21.3 0.0 0.00024 20.3 0.0 1.5 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.17 ESS66400.1 - 0.0006 19.2 0.0 0.016 14.5 0.0 2.6 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase FUSC_2 PF13515.1 ESS66402.1 - 1.6e-13 50.6 27.7 7.4e-13 48.5 6.2 2.6 3 0 0 3 3 3 2 Fusaric acid resistance protein-like TPR_11 PF13414.1 ESS66403.1 - 5.2e-10 38.8 6.6 0.00036 20.1 0.1 4.3 5 0 0 5 5 5 2 TPR repeat TPR_8 PF13181.1 ESS66403.1 - 1e-06 28.0 1.5 1.5e-05 24.3 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66403.1 - 0.00021 20.7 4.0 1.6 8.4 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66403.1 - 0.0015 18.2 15.8 0.14 12.1 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66403.1 - 0.0037 17.1 10.0 3.8 7.5 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66403.1 - 0.0088 16.6 18.1 0.011 16.4 0.1 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66403.1 - 0.019 15.5 24.0 0.24 12.1 0.2 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS66403.1 - 2.4 8.7 18.2 15 6.3 0.2 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66403.1 - 4.1 7.8 8.0 4.2 7.7 0.1 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESS66404.1 - 0.0036 16.9 1.0 0.38 10.4 0.1 2.7 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.1 ESS66404.1 - 0.0061 17.0 0.8 2.3 9.0 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66404.1 - 0.038 14.3 0.5 0.14 12.4 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS66404.1 - 0.044 13.5 0.6 1.9 8.5 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66404.1 - 0.12 12.3 0.6 26 5.0 0.0 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Filament PF00038.16 ESS66405.1 - 0.00079 18.9 12.3 0.0019 17.7 8.5 1.6 1 0 0 1 1 1 1 Intermediate filament protein DUF342 PF03961.8 ESS66405.1 - 0.39 9.0 3.1 0.61 8.4 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4337 PF14235.1 ESS66405.1 - 0.77 9.5 2.8 1.5 8.6 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) PGI PF00342.14 ESS66406.1 - 1.8e-228 758.8 0.0 2.1e-228 758.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase V_ATPase_I PF01496.14 ESS66413.1 - 2.2 6.0 13.8 3.5 5.3 9.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nup88 PF10168.4 ESS66413.1 - 8.7 4.0 16.0 12 3.6 11.1 1.1 1 0 0 1 1 1 0 Nuclear pore component zf-CW PF07496.10 ESS66414.1 - 1.2e-14 53.6 14.7 7.9e-10 38.2 4.5 3.7 3 0 0 3 3 3 2 CW-type Zinc Finger AAA_18 PF13238.1 ESS66414.1 - 0.0073 16.6 2.2 0.02 15.2 1.5 1.8 1 0 0 1 1 1 1 AAA domain Guanylate_kin PF00625.16 ESS66415.1 - 3.7e-08 33.0 0.3 4.1e-08 32.8 0.2 1.0 1 0 0 1 1 1 1 Guanylate kinase Lebercilin PF15619.1 ESS66415.1 - 0.04 13.3 1.1 0.04 13.3 0.8 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease YEATS PF03366.11 ESS66416.1 - 3.7e-11 42.5 0.1 6.8e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 YEATS family CBS PF00571.23 ESS66417.1 - 0.00036 20.2 0.1 0.00075 19.2 0.1 1.5 1 0 0 1 1 1 1 CBS domain IPT PF01745.11 ESS66417.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Isopentenyl transferase Voltage_CLC PF00654.15 ESS66418.1 - 3.7e-85 286.0 31.2 8.5e-85 284.8 19.7 2.1 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 ESS66418.1 - 0.0006 19.5 0.1 0.0013 18.4 0.1 1.6 1 0 0 1 1 1 1 CBS domain Abhydrolase_5 PF12695.2 ESS66419.1 - 0.0029 17.3 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DNA_primase_lrg PF04104.9 ESS66420.1 - 0.11 11.6 1.5 0.19 10.9 0.0 2.0 2 1 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit PPTA PF01239.17 ESS66422.1 - 9.7e-25 84.8 8.6 9.7e-07 27.8 0.5 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat E1-E2_ATPase PF00122.15 ESS66423.1 - 1e-47 162.1 0.2 2.3e-47 160.9 0.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESS66423.1 - 2e-36 125.2 9.2 2.9e-36 124.6 4.6 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESS66423.1 - 2.6e-14 54.1 0.0 1.2e-12 48.7 0.0 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS66423.1 - 8.1e-13 48.9 0.0 4e-12 46.7 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESS66423.1 - 5.7e-06 26.0 0.2 1.2e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS66423.1 - 0.00021 21.1 0.0 0.00051 19.9 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 ESS66423.1 - 0.00076 18.8 0.0 0.002 17.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Lactamase_B PF00753.22 ESS66423.1 - 0.17 11.4 0.0 0.43 10.2 0.0 1.6 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily WW PF00397.21 ESS66424.1 - 0.66 9.9 7.3 0.17 11.7 1.8 2.6 2 0 0 2 2 2 0 WW domain Nucleoplasmin PF03066.10 ESS66424.1 - 2.6 7.5 12.0 25 4.3 8.1 2.2 2 0 0 2 2 2 0 Nucleoplasmin NAPRTase PF04095.11 ESS66425.1 - 2e-64 217.2 0.0 2.9e-64 216.7 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family WD40 PF00400.27 ESS66426.1 - 1.1e-15 56.8 4.2 0.00013 21.6 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat FIBP PF05427.6 ESS66427.1 - 0.0001 21.6 0.3 0.00096 18.4 0.2 2.2 1 1 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) DUF1192 PF06698.6 ESS66431.1 - 0.53 10.1 2.7 0.4 10.5 0.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) DUF3899 PF13038.1 ESS66434.1 - 0.5 10.5 2.7 0.49 10.5 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) Gemini_C4 PF01492.12 ESS66437.1 - 0.025 14.2 0.0 0.084 12.6 0.0 1.9 1 0 0 1 1 1 0 Geminivirus C4 protein NIF PF03031.13 ESS66438.1 - 2.2e-25 89.2 0.0 1.2e-20 73.7 0.0 2.3 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase Acid_phosphat_B PF03767.9 ESS66438.1 - 0.067 12.5 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Cyclin PF08613.6 ESS66439.1 - 1e-31 110.3 0.0 4.7e-31 108.2 0.0 2.1 2 1 0 2 2 2 1 Cyclin Zip PF02535.17 ESS66439.1 - 1.1 8.1 9.6 3 6.7 6.6 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter APG17 PF04108.7 ESS66441.1 - 0.068 11.9 0.2 0.098 11.4 0.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 Nsp1_C PF05064.8 ESS66441.1 - 0.24 11.0 2.0 0.47 10.1 1.4 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF3552 PF12072.3 ESS66441.1 - 1.2 8.3 6.7 1.9 7.6 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) WD40 PF00400.27 ESS66446.1 - 2.3e-13 49.4 6.8 0.00016 21.4 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat PTR2 PF00854.16 ESS66448.1 - 6.1e-31 107.5 9.8 4.1e-30 104.7 6.8 1.9 1 1 0 1 1 1 1 POT family MFS_1 PF07690.11 ESS66448.1 - 4e-09 35.6 24.3 5.9e-07 28.5 8.0 3.4 1 1 2 3 3 3 3 Major Facilitator Superfamily IncA PF04156.9 ESS66448.1 - 1.1 8.8 4.7 11 5.5 0.0 2.8 3 0 0 3 3 3 0 IncA protein BNR_3 PF13859.1 ESS66449.1 - 1.8e-91 306.4 1.0 2.6e-91 305.9 0.7 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Tr-sialidase_C PF11052.3 ESS66449.1 - 5.4e-09 35.7 3.1 1.5e-08 34.3 2.2 1.9 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Laminin_G_3 PF13385.1 ESS66449.1 - 1.2e-07 32.1 1.1 1.2e-07 32.1 0.8 2.8 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RHSP PF07999.6 ESS66450.1 - 1.5e-78 264.3 0.0 2.6e-78 263.6 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF2854 PF11016.3 ESS66450.1 - 0.073 12.6 0.3 0.13 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) BRI3BP PF14965.1 ESS66451.1 - 0.14 11.4 0.7 0.16 11.3 0.5 1.0 1 0 0 1 1 1 0 Negative regulator of p53/TP53 PsbJ PF01788.12 ESS66451.1 - 1.9 8.0 4.2 3.8 7.1 0.9 2.3 1 1 1 2 2 2 0 PsbJ ERG4_ERG24 PF01222.12 ESS66453.1 - 3.6e-79 266.3 12.4 4.2e-79 266.0 8.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DASH_Dam1 PF08653.5 ESS66455.1 - 0.11 12.3 1.2 2.5 7.9 0.1 3.1 2 0 0 2 2 2 0 DASH complex subunit Dam1 EF-hand_7 PF13499.1 ESS66456.1 - 2.4e-09 37.1 0.1 1.1e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS66456.1 - 1.8e-06 27.4 0.2 5.8e-05 22.6 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS66456.1 - 5.6e-05 22.6 0.0 0.0043 16.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 ESS66456.1 - 0.0049 16.0 0.2 0.18 11.2 0.0 3.2 4 0 0 4 4 4 1 EF hand YozD PF14162.1 ESS66456.1 - 0.019 15.0 0.1 3.8 7.6 0.1 2.7 2 0 0 2 2 2 0 YozD-like protein EF-hand_9 PF14658.1 ESS66456.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Apolipoprotein PF01442.13 ESS66457.1 - 0.01 15.3 4.4 0.018 14.5 3.1 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Snapin_Pallidin PF14712.1 ESS66457.1 - 0.016 15.4 5.5 0.016 15.4 3.8 3.2 3 0 0 3 3 3 0 Snapin/Pallidin IFT57 PF10498.4 ESS66458.1 - 3.9e-127 423.9 0.1 4.5e-127 423.7 0.0 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Tropomyosin PF00261.15 ESS66458.1 - 0.00049 19.2 5.6 0.00076 18.6 3.9 1.3 1 0 0 1 1 1 1 Tropomyosin DUF1978 PF09321.5 ESS66458.1 - 0.0015 17.9 5.0 0.0027 17.1 3.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1978) AAA_13 PF13166.1 ESS66458.1 - 0.0044 15.5 3.6 0.006 15.1 2.5 1.1 1 0 0 1 1 1 1 AAA domain Reo_sigmaC PF04582.7 ESS66458.1 - 0.01 15.0 1.3 0.015 14.4 0.9 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Spc7 PF08317.6 ESS66458.1 - 0.012 14.2 4.4 0.021 13.5 3.1 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Mnd1 PF03962.10 ESS66458.1 - 0.015 14.9 4.9 0.028 14.1 3.4 1.4 1 0 0 1 1 1 0 Mnd1 family DUF2408 PF10303.4 ESS66458.1 - 0.036 14.1 2.5 0.07 13.2 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) MCPsignal PF00015.16 ESS66458.1 - 0.038 13.5 4.2 0.12 11.9 2.9 1.7 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CR6_interact PF10147.4 ESS66458.1 - 0.043 13.1 2.0 0.07 12.4 1.4 1.4 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Laminin_II PF06009.7 ESS66458.1 - 0.045 13.5 7.0 0.2 11.3 4.7 2.1 1 1 0 1 1 1 0 Laminin Domain II AKNA PF12443.3 ESS66458.1 - 0.06 13.3 6.9 1.6 8.8 2.0 2.5 1 1 1 2 2 2 0 AT-hook-containing transcription factor V_ATPase_I PF01496.14 ESS66458.1 - 0.077 10.8 4.5 0.1 10.4 3.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ApoLp-III PF07464.6 ESS66458.1 - 0.094 12.7 7.1 0.19 11.7 0.3 2.3 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF4404 PF14357.1 ESS66458.1 - 0.15 12.5 4.9 2.8 8.4 0.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) TPR_MLP1_2 PF07926.7 ESS66458.1 - 0.15 11.8 8.5 0.22 11.2 5.3 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 ESS66458.1 - 0.19 11.2 11.5 0.52 9.8 1.8 2.1 1 1 1 2 2 2 0 IncA protein Baculo_PEP_C PF04513.7 ESS66458.1 - 0.22 11.3 3.0 1.7 8.4 1.0 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.13 ESS66458.1 - 0.25 10.8 12.6 0.53 9.7 8.7 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain COG2 PF06148.6 ESS66458.1 - 0.27 11.1 7.9 1.6 8.6 1.8 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MutS_III PF05192.13 ESS66458.1 - 0.38 10.5 2.9 0.61 9.8 2.0 1.3 1 0 0 1 1 1 0 MutS domain III FUSC PF04632.7 ESS66458.1 - 0.38 9.1 2.4 0.5 8.7 1.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.7 ESS66458.1 - 0.52 10.1 8.6 1.3 8.8 1.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.6 ESS66458.1 - 0.59 10.0 4.8 0.63 9.9 0.7 2.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.8 ESS66458.1 - 0.67 9.4 5.7 1.5 8.3 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) TMF_DNA_bd PF12329.3 ESS66458.1 - 1.2 9.0 7.0 2 8.2 1.3 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding GAS PF13851.1 ESS66458.1 - 2.2 7.3 10.1 1.2 8.2 4.2 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.17 ESS66458.1 - 2.3 8.2 7.4 14 5.7 5.0 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TBCA PF02970.11 ESS66458.1 - 2.3 8.3 9.7 10 6.2 1.6 2.9 1 1 1 2 2 2 0 Tubulin binding cofactor A NPV_P10 PF05531.7 ESS66458.1 - 2.5 8.4 7.3 55 4.1 2.6 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF2203 PF09969.4 ESS66458.1 - 2.7 8.2 4.9 3.8 7.7 1.6 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) WXG100 PF06013.7 ESS66458.1 - 5.4 7.1 7.6 13 5.8 0.4 3.1 2 1 1 3 3 2 0 Proteins of 100 residues with WXG Apc3 PF12895.2 ESS66459.1 - 0.00051 20.1 0.2 0.12 12.5 0.0 3.4 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESS66459.1 - 0.00064 19.3 0.7 7.2 6.6 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat PPR PF01535.15 ESS66459.1 - 0.016 15.1 0.2 7.7 6.7 0.0 4.3 6 0 0 6 6 6 0 PPR repeat TPR_2 PF07719.12 ESS66459.1 - 0.21 11.6 1.4 27 5.0 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.17 ESS66460.1 - 5.9e-13 48.2 0.3 2e-11 43.3 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66460.1 - 4.5e-08 32.9 0.1 1e-06 28.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS66460.1 - 8.3e-07 28.7 0.1 3.2e-06 26.9 0.0 2.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESS66460.1 - 0.091 12.5 0.0 0.52 10.1 0.0 2.2 2 1 0 2 2 2 0 Limkain b1 DUF4449 PF14613.1 ESS66461.1 - 0.0058 16.5 9.9 0.0058 16.5 6.9 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF4449) Reo_sigmaC PF04582.7 ESS66461.1 - 0.0084 15.3 5.0 0.34 10.0 0.9 2.1 1 1 1 2 2 2 2 Reovirus sigma C capsid protein Exonuc_VII_L PF02601.10 ESS66461.1 - 0.018 14.2 20.1 0.03 13.5 14.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin-6_N PF09177.6 ESS66461.1 - 0.025 14.9 1.6 0.025 14.9 1.1 3.3 1 1 1 2 2 1 0 Syntaxin 6, N-terminal MscS_porin PF12795.2 ESS66461.1 - 0.16 11.2 36.1 0.3 10.3 5.0 3.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain ADIP PF11559.3 ESS66461.1 - 0.18 11.6 39.9 2.3 8.1 9.9 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.4 ESS66461.1 - 0.22 11.4 40.8 0.15 11.9 3.3 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ApoB100_C PF12491.3 ESS66461.1 - 0.25 10.9 2.7 1.6 8.3 0.5 2.8 2 1 0 2 2 2 0 Apolipoprotein B100 C terminal TPR_MLP1_2 PF07926.7 ESS66461.1 - 0.28 10.9 43.5 2 8.1 3.6 3.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein RmuC PF02646.11 ESS66461.1 - 0.38 9.5 29.8 0.04 12.7 5.6 3.1 1 1 1 3 3 3 0 RmuC family GAS PF13851.1 ESS66461.1 - 0.45 9.6 40.8 0.9 8.6 12.5 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Ribosomal_S24e PF01282.14 ESS66461.1 - 0.48 10.2 8.3 0.15 11.8 2.4 2.4 2 0 0 2 2 2 0 Ribosomal protein S24e Tropomyosin_1 PF12718.2 ESS66461.1 - 0.56 10.0 42.1 0.53 10.1 6.5 2.9 1 1 1 2 2 2 0 Tropomyosin like AAA_13 PF13166.1 ESS66461.1 - 0.69 8.2 32.6 0.89 7.9 22.6 1.0 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 ESS66461.1 - 1.7 8.1 44.9 1.1e+04 -4.3 31.0 2.9 1 1 0 1 1 0 0 IncA protein Tropomyosin PF00261.15 ESS66461.1 - 2.2 7.2 41.8 0.92 8.5 7.1 2.6 1 1 1 2 2 2 0 Tropomyosin FUSC PF04632.7 ESS66461.1 - 3.4 6.0 7.8 4.8 5.4 5.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF972 PF06156.8 ESS66461.1 - 3.6 7.9 34.2 0.49 10.7 5.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF972) ERM PF00769.14 ESS66461.1 - 3.7 6.9 42.7 0.14 11.6 16.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Cob_adeno_trans PF01923.13 ESS66461.1 - 4 7.1 20.9 0.049 13.4 3.1 3.1 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Ribonucleas_3_2 PF11469.3 ESS66461.1 - 4.8 7.3 7.5 8.7 6.5 0.1 2.8 3 0 0 3 3 3 0 Ribonuclease III YgbB PF02542.11 ESS66461.1 - 5.3 6.8 6.5 1.3 8.8 0.7 2.2 2 1 0 2 2 2 0 YgbB family ATG16 PF08614.6 ESS66461.1 - 6 6.6 35.9 2.7 7.7 8.4 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Cast PF10174.4 ESS66461.1 - 6.5 4.6 42.2 2.8 5.8 17.7 2.0 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone Barstar PF01337.13 ESS66461.1 - 6.6 6.6 9.7 15 5.4 0.1 3.5 2 1 2 4 4 4 0 Barstar (barnase inhibitor) COG2 PF06148.6 ESS66461.1 - 6.7 6.5 26.3 0.56 10.0 5.2 3.6 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.5 ESS66461.1 - 7.7 6.6 31.8 2.3 8.3 10.9 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family APG6 PF04111.7 ESS66461.1 - 8.7 5.2 42.3 0.32 9.9 15.5 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 BRE1 PF08647.6 ESS66462.1 - 6.4e-21 74.1 18.3 6.4e-21 74.1 12.7 8.6 5 2 4 9 9 9 4 BRE1 E3 ubiquitin ligase AAA_13 PF13166.1 ESS66462.1 - 0.00027 19.5 18.1 0.00027 19.5 12.5 5.2 1 1 2 4 4 4 2 AAA domain Reo_sigmaC PF04582.7 ESS66462.1 - 0.0036 16.5 31.3 0.36 9.9 0.2 5.4 2 2 3 5 5 5 4 Reovirus sigma C capsid protein GAS PF13851.1 ESS66462.1 - 0.0036 16.5 13.5 0.0036 16.5 9.4 6.6 2 2 3 6 6 5 2 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.3 ESS66462.1 - 0.0049 16.5 15.0 0.0049 16.5 10.4 9.0 2 2 7 9 9 7 3 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.17 ESS66462.1 - 0.0063 16.5 13.0 0.0063 16.5 9.0 8.5 2 2 6 9 9 9 2 Seryl-tRNA synthetase N-terminal domain Myosin_tail_1 PF01576.14 ESS66462.1 - 0.0089 13.8 104.2 0.021 12.5 14.8 3.2 1 1 0 2 2 2 1 Myosin tail Laminin_II PF06009.7 ESS66462.1 - 0.0099 15.6 7.3 0.0099 15.6 5.0 6.9 2 2 7 9 9 9 3 Laminin Domain II Med9 PF07544.8 ESS66462.1 - 0.2 11.4 0.1 0.2 11.4 0.1 9.0 4 3 4 9 9 8 0 RNA polymerase II transcription mediator complex subunit 9 CENP-F_leu_zip PF10473.4 ESS66462.1 - 3 7.6 114.3 0.81 9.5 6.0 8.3 1 1 6 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 ESS66462.1 - 3.6 7.1 102.8 0.18 11.3 6.3 6.2 2 2 4 6 6 6 0 IncA protein Cast PF10174.4 ESS66462.1 - 6.3 4.7 103.2 3e+02 -0.9 71.4 2.6 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone SynMuv_product PF06047.6 ESS66464.1 - 2e-10 40.3 3.2 2e-10 40.3 2.2 2.1 2 0 0 2 2 2 1 Ras-induced vulval development antagonist Extensin_2 PF04554.8 ESS66465.1 - 0.021 14.6 28.8 0.35 10.7 10.7 2.4 1 1 1 2 2 2 0 Extensin-like region IGR PF09597.5 ESS66466.1 - 0.0026 17.5 0.0 0.0063 16.3 0.0 1.7 1 0 0 1 1 1 1 IGR protein motif RRM_1 PF00076.17 ESS66476.1 - 0.0007 19.1 0.0 0.0017 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66476.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-TRAF PF02176.13 ESS66477.1 - 0.001 19.4 7.3 0.045 14.1 0.5 3.0 2 1 1 3 3 3 2 TRAF-type zinc finger SET PF00856.23 ESS66478.1 - 0.0019 18.5 0.0 0.23 11.7 0.0 2.3 2 0 0 2 2 2 2 SET domain Phage_int_SAM_4 PF13495.1 ESS66478.1 - 0.038 14.3 0.0 13 6.2 0.0 2.5 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Reo_sigmaC PF04582.7 ESS66479.1 - 0.0019 17.4 0.2 0.0032 16.6 0.1 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein AAA_13 PF13166.1 ESS66479.1 - 0.011 14.1 0.7 0.016 13.7 0.5 1.1 1 0 0 1 1 1 0 AAA domain COG2 PF06148.6 ESS66479.1 - 0.025 14.4 3.7 3.5 7.5 0.0 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CENP-F_leu_zip PF10473.4 ESS66479.1 - 0.027 14.3 5.1 0.074 12.9 3.6 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2730 PF10805.3 ESS66479.1 - 0.031 14.0 1.1 0.085 12.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) CENP-Q PF13094.1 ESS66479.1 - 0.049 13.6 2.3 0.082 12.9 1.6 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PspA_IM30 PF04012.7 ESS66479.1 - 0.052 12.8 2.0 0.1 11.9 1.4 1.4 1 1 0 1 1 1 0 PspA/IM30 family DUF4618 PF15397.1 ESS66479.1 - 0.074 12.3 1.9 1 8.6 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Spc7 PF08317.6 ESS66479.1 - 0.081 11.5 1.6 0.15 10.6 0.7 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Laminin_II PF06009.7 ESS66479.1 - 0.22 11.2 1.3 2.4 7.9 0.3 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF1664 PF07889.7 ESS66479.1 - 0.26 11.0 0.7 0.82 9.4 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Lebercilin PF15619.1 ESS66479.1 - 0.31 10.4 5.3 1 8.7 3.7 1.8 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Kinesin-relat_1 PF12711.2 ESS66479.1 - 2.6 8.5 7.3 0.48 10.8 2.3 1.9 2 1 0 2 2 1 0 Kinesin motor IncA PF04156.9 ESS66479.1 - 4.8 6.7 7.3 18 4.8 5.2 1.8 1 1 0 1 1 1 0 IncA protein Metallophos PF00149.23 ESS66480.1 - 3.6e-12 46.0 0.1 5.9e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESS66480.1 - 7.9e-10 38.7 0.0 1.3e-09 38.0 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF4498 PF14926.1 ESS66481.1 - 5e-23 81.5 0.0 1.6e-10 40.5 0.0 4.7 5 0 0 5 5 5 4 Domain of unknown function (DUF4498) EMP24_GP25L PF01105.19 ESS66482.1 - 3.6e-37 127.8 0.1 4.9e-37 127.4 0.1 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4184 PF13803.1 ESS66482.1 - 0.012 14.9 0.4 0.023 14.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4184) ANTH PF07651.11 ESS66482.1 - 0.024 13.3 0.1 0.031 13.0 0.1 1.1 1 0 0 1 1 1 0 ANTH domain EAP30 PF04157.11 ESS66482.1 - 0.077 12.1 0.2 0.1 11.7 0.1 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family Antibiotic_NAT PF02522.9 ESS66482.1 - 0.088 12.0 0.2 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase Abhydrolase_6 PF12697.2 ESS66483.1 - 4.5e-10 39.8 0.1 5.2e-10 39.5 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS66483.1 - 3.4e-06 26.8 0.0 2e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S10 PF00450.17 ESS66483.1 - 0.034 13.3 0.0 0.039 13.1 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase DUF3638 PF12340.3 ESS66486.1 - 6.4e-28 97.3 0.4 1.6e-23 82.9 0.4 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.3 ESS66486.1 - 1.5e-12 46.3 1.4 7.5e-12 44.1 0.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) zf-RanBP PF00641.13 ESS66486.1 - 2.2e-05 23.4 2.7 2.2e-05 23.4 1.9 3.4 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others Thioredoxin_8 PF13905.1 ESS66488.1 - 2.1e-08 34.1 0.0 8e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like ubiquitin PF00240.18 ESS66488.1 - 0.26 10.7 0.0 0.59 9.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family H_PPase PF03030.11 ESS66489.1 - 2.5e-253 842.3 36.8 3.2e-253 842.0 25.5 1.1 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase DUF4234 PF14018.1 ESS66489.1 - 0.14 11.8 1.8 1.8 8.3 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) ETRAMP PF09716.5 ESS66489.1 - 0.14 12.0 5.1 4.2 7.4 0.0 3.5 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Kinesin PF00225.18 ESS66492.1 - 8.4e-79 264.6 0.0 1.1e-76 257.7 0.0 2.3 1 1 0 1 1 1 1 Kinesin motor domain LRR_6 PF13516.1 ESS66493.1 - 9.8e-05 22.0 3.3 0.2 11.7 0.1 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 ESS66493.1 - 0.00033 20.2 2.2 0.0011 18.5 1.6 1.9 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS66493.1 - 0.00066 19.3 1.0 1.3 9.3 0.2 3.2 2 0 0 2 2 2 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS66493.1 - 0.077 13.2 0.5 20 5.9 0.1 3.1 2 0 0 2 2 2 0 Leucine rich repeat LRR_8 PF13855.1 ESS66493.1 - 0.2 11.4 3.4 0.73 9.6 2.3 1.9 1 1 0 1 1 1 0 Leucine rich repeat T2SG PF08334.6 ESS66496.1 - 0.046 13.4 4.7 2.4 7.9 0.0 3.5 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein G ABC_membrane PF00664.18 ESS66497.1 - 1.6e-52 178.6 25.5 1.8e-30 106.3 10.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESS66497.1 - 3e-44 150.6 0.0 6.4e-25 88.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESS66497.1 - 4.3e-10 39.2 0.0 0.014 14.6 0.1 4.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESS66497.1 - 6.2e-08 32.0 2.2 0.00038 19.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 ESS66497.1 - 1.1e-07 32.0 0.1 0.0068 16.4 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 ESS66497.1 - 3.5e-07 29.8 0.0 0.0036 16.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 ESS66497.1 - 1e-06 29.2 0.2 0.02 15.3 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein MMR_HSR1 PF01926.18 ESS66497.1 - 1.5e-05 24.8 0.2 0.23 11.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESS66497.1 - 2.1e-05 24.3 2.2 0.0086 15.9 0.0 3.3 3 0 0 3 3 3 1 Dynamin family AAA_21 PF13304.1 ESS66497.1 - 4.8e-05 23.4 0.0 0.45 10.4 0.0 3.9 3 1 1 4 4 4 1 AAA domain DUF258 PF03193.11 ESS66497.1 - 6.2e-05 22.2 0.7 0.014 14.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MobB PF03205.9 ESS66497.1 - 0.00019 21.1 1.2 0.086 12.5 0.1 3.0 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 ESS66497.1 - 0.0002 20.3 0.1 0.48 9.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_10 PF12846.2 ESS66497.1 - 0.00039 19.9 0.2 0.22 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain AAA_22 PF13401.1 ESS66497.1 - 0.00053 20.1 0.0 0.2 11.8 0.0 3.1 3 0 0 3 3 2 1 AAA domain CAP_GLY PF01302.20 ESS66497.1 - 0.0011 18.6 0.0 0.0049 16.5 0.0 2.2 1 0 0 1 1 1 1 CAP-Gly domain ATP-synt_ab PF00006.20 ESS66497.1 - 0.0016 18.0 0.3 1 8.8 0.0 2.7 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 ESS66497.1 - 0.0035 16.8 3.2 1.1 8.7 0.0 2.9 3 0 0 3 3 2 2 FtsK/SpoIIIE family AAA_23 PF13476.1 ESS66497.1 - 0.0043 17.4 11.6 0.0051 17.1 0.1 3.6 3 0 0 3 3 3 1 AAA domain DUF87 PF01935.12 ESS66497.1 - 0.0061 16.3 7.8 0.45 10.3 0.1 3.3 4 0 0 4 4 3 2 Domain of unknown function DUF87 NACHT PF05729.7 ESS66497.1 - 0.012 15.2 1.0 0.96 9.0 0.0 3.2 3 0 0 3 3 3 0 NACHT domain AAA_17 PF13207.1 ESS66497.1 - 0.014 16.2 0.0 13 6.6 0.0 3.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 ESS66497.1 - 0.018 14.6 0.2 3.1 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESS66497.1 - 0.032 13.3 1.1 1.8 7.5 0.0 2.8 3 0 0 3 3 2 0 Zeta toxin AAA_33 PF13671.1 ESS66497.1 - 0.035 13.9 0.5 0.99 9.2 0.0 3.1 2 1 0 2 2 2 0 AAA domain cobW PF02492.14 ESS66497.1 - 0.054 12.9 2.2 1.9 7.8 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.13 ESS66497.1 - 0.073 12.0 0.1 1.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Septin Viral_helicase1 PF01443.13 ESS66497.1 - 0.11 11.9 0.0 4.7 6.6 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase IIGP PF05049.8 ESS66497.1 - 0.12 11.1 0.5 13 4.4 0.0 2.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.22 ESS66497.1 - 0.14 11.5 0.9 1.9 7.8 0.1 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Cut8_N PF14482.1 ESS66497.1 - 0.58 10.2 5.8 0.14 12.1 0.7 2.5 2 0 0 2 2 2 0 Cut8 proteasome-binding domain AAA_18 PF13238.1 ESS66497.1 - 1.2 9.4 9.2 4.6 7.5 0.0 4.6 5 0 0 5 5 4 0 AAA domain DUF1019 PF06254.6 ESS66499.1 - 0.17 12.0 0.8 0.27 11.4 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1019) PP2C PF00481.16 ESS66501.1 - 1.7e-30 106.3 0.0 7.8e-26 91.0 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 ESS66501.1 - 0.033 13.5 0.1 0.38 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein phosphatase 2C Pkinase PF00069.20 ESS66503.1 - 2.1e-68 230.3 0.0 2.7e-68 229.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66503.1 - 2e-34 118.8 0.0 2.9e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.16 ESS66503.1 - 1.6e-07 31.0 7.8 3.6e-07 29.9 5.4 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.24 ESS66503.1 - 1.3e-06 28.4 0.0 2.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 ESS66503.1 - 2.4e-05 23.4 0.0 4.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESS66503.1 - 0.0038 16.3 0.1 0.0096 15.0 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PH_11 PF15413.1 ESS66503.1 - 0.045 14.0 0.0 0.18 12.0 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain CSD PF00313.17 ESS66504.1 - 6.5e-13 48.2 0.2 7.6e-09 35.2 0.1 2.6 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain DUF641 PF04859.7 ESS66505.1 - 0.0012 18.5 7.6 0.0012 18.5 5.3 7.1 4 3 4 8 8 8 1 Plant protein of unknown function (DUF641) SPRY PF00622.23 ESS66505.1 - 0.028 14.5 0.1 0.11 12.5 0.1 1.9 2 0 0 2 2 2 0 SPRY domain BAF1_ABF1 PF04684.8 ESS66506.1 - 0.74 8.6 6.5 1.3 7.8 4.5 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Aldedh PF00171.17 ESS66508.1 - 1.9e-15 56.1 1.0 5.5e-07 28.2 0.0 2.5 2 1 0 2 2 2 2 Aldehyde dehydrogenase family Pigment_DH PF06324.6 ESS66509.1 - 0.73 9.1 4.0 0.18 11.1 0.1 1.9 2 0 0 2 2 2 0 Pigment-dispersing hormone (PDH) Pkinase PF00069.20 ESS66512.1 - 1e-49 169.0 0.0 7.8e-49 166.1 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66512.1 - 2.2e-34 118.6 0.0 1.6e-31 109.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase PH_3 PF14593.1 ESS66512.1 - 1.3e-19 69.9 0.1 3.4e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 ESS66512.1 - 0.0004 19.4 0.0 0.00061 18.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS66512.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESS66512.1 - 0.12 11.6 0.0 0.4 9.9 0.0 1.8 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 ESS66512.1 - 0.17 11.4 0.1 0.73 9.3 0.1 1.8 1 1 1 2 2 2 0 Choline/ethanolamine kinase L51_S25_CI-B8 PF05047.11 ESS66513.1 - 1.3e-05 24.8 0.0 6.1e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Glyco_tranf_2_5 PF13712.1 ESS66513.1 - 0.031 13.5 0.2 0.55 9.4 0.0 2.4 2 1 1 3 3 3 0 Glycosyltransferase like family Cmc1 PF08583.5 ESS66515.1 - 0.023 14.4 4.6 0.052 13.3 3.2 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like zf-RING-like PF08746.6 ESS66515.1 - 0.14 12.1 1.0 0.23 11.5 0.7 1.4 1 0 0 1 1 1 0 RING-like domain TP_methylase PF00590.15 ESS66516.1 - 5.3e-18 65.4 0.0 9.1e-18 64.7 0.0 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.1 ESS66516.1 - 0.05 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Thiolase_N PF00108.18 ESS66517.1 - 1.4e-61 207.8 0.1 1.9e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 ESS66517.1 - 1.2e-34 118.4 0.0 2.5e-34 117.3 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 ESS66517.1 - 5.6e-07 29.2 1.8 1.6e-06 27.7 1.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.6 ESS66517.1 - 0.00016 20.2 0.1 0.00033 19.2 0.1 1.4 1 0 0 1 1 1 1 Stage V sporulation protein AD (SpoVAD) ACP_syn_III PF08545.5 ESS66517.1 - 0.0083 15.7 0.7 0.11 12.2 0.3 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FAE1_CUT1_RppA PF08392.7 ESS66517.1 - 0.028 13.4 0.3 0.051 12.6 0.2 1.3 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein DUF3236 PF11576.3 ESS66517.1 - 0.046 13.1 0.1 0.11 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) His_Phos_2 PF00328.17 ESS66527.1 - 6.2e-21 75.1 2.3 3.5e-10 39.7 0.1 2.8 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) 3HCDH_N PF02737.13 ESS66528.1 - 6.2e-54 182.3 0.3 8e-54 182.0 0.2 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 ESS66528.1 - 8.1e-33 112.7 0.0 2.7e-32 111.0 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain AlaDh_PNT_C PF01262.16 ESS66528.1 - 0.026 14.1 0.0 0.053 13.0 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.12 ESS66528.1 - 0.093 13.1 0.1 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 ESS66528.1 - 0.12 12.2 0.3 0.26 11.1 0.2 1.7 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 ESS66528.1 - 0.27 10.9 2.7 0.4 10.4 0.8 2.0 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HEAT_EZ PF13513.1 ESS66529.1 - 0.0015 18.9 4.4 1.6 9.3 0.0 4.7 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.1 ESS66529.1 - 0.0098 16.1 0.2 0.17 12.1 0.0 3.2 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.17 ESS66529.1 - 0.019 14.9 3.5 5.5 7.3 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat Arm PF00514.18 ESS66529.1 - 0.075 12.8 0.9 1.8 8.5 0.0 3.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat IBN_N PF03810.14 ESS66529.1 - 5.9 6.8 6.3 4 7.4 0.3 3.3 3 1 0 3 3 3 0 Importin-beta N-terminal domain Peptidase_M41 PF01434.13 ESS66530.1 - 5.4e-68 228.6 1.7 8e-68 228.0 1.2 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESS66530.1 - 8e-43 145.7 0.0 1.7e-42 144.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESS66530.1 - 1.3e-06 28.1 0.0 5.1e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 ESS66530.1 - 1.6e-06 27.7 0.1 0.00033 20.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 ESS66530.1 - 2.5e-05 23.4 0.0 7.8e-05 21.8 0.0 1.9 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESS66530.1 - 2.9e-05 23.9 0.0 0.0001 22.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESS66530.1 - 4e-05 23.7 1.3 0.0018 18.4 0.1 3.3 2 1 1 3 3 3 1 AAA domain AAA_17 PF13207.1 ESS66530.1 - 0.0001 23.0 0.0 0.00039 21.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS66530.1 - 0.00011 22.1 0.1 0.01 15.8 0.0 3.0 3 1 0 4 4 2 1 AAA ATPase domain NACHT PF05729.7 ESS66530.1 - 0.00056 19.6 0.1 0.014 15.0 0.0 2.4 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.12 ESS66530.1 - 0.0011 18.4 0.0 0.0026 17.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 ESS66530.1 - 0.0012 17.9 0.0 0.0026 16.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 ESS66530.1 - 0.0018 18.1 0.0 0.0048 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESS66530.1 - 0.002 16.8 0.0 0.0049 15.6 0.0 1.6 1 0 0 1 1 1 1 TIP49 C-terminus AAA_18 PF13238.1 ESS66530.1 - 0.0038 17.5 0.0 0.02 15.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 ESS66530.1 - 0.0042 16.2 0.2 0.008 15.3 0.1 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ESS66530.1 - 0.0048 16.8 0.0 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESS66530.1 - 0.0059 16.5 0.0 0.017 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 ESS66530.1 - 0.0095 15.6 0.1 0.033 13.9 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain ABC_tran PF00005.22 ESS66530.1 - 0.019 15.2 0.5 0.1 12.8 0.1 2.5 3 0 0 3 3 1 0 ABC transporter RNA_helicase PF00910.17 ESS66530.1 - 0.021 14.9 0.0 0.054 13.6 0.0 1.8 1 1 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.20 ESS66530.1 - 0.029 13.8 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.10 ESS66530.1 - 0.042 12.5 0.0 0.077 11.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF3367 PF11847.3 ESS66530.1 - 0.047 11.6 0.3 0.076 10.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3367) Arch_ATPase PF01637.13 ESS66530.1 - 0.048 13.3 0.0 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 Archaeal ATPase NB-ARC PF00931.17 ESS66530.1 - 0.056 12.2 0.2 0.18 10.6 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain AAA_10 PF12846.2 ESS66530.1 - 0.082 12.3 0.2 0.66 9.3 0.0 2.4 3 0 0 3 3 3 0 AAA-like domain DUF815 PF05673.8 ESS66530.1 - 0.088 11.7 0.0 0.35 9.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) KaiC PF06745.8 ESS66530.1 - 0.098 11.7 0.3 2.3 7.2 0.0 2.9 3 0 0 3 3 3 0 KaiC Pentapeptide_4 PF13599.1 ESS66533.1 - 1.5e-08 34.3 17.5 2.1e-06 27.4 4.0 2.3 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.17 ESS66533.1 - 8.1e-08 31.3 6.0 0.012 14.8 1.3 3.9 1 1 3 4 4 4 3 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.1 ESS66533.1 - 5e-05 23.0 12.1 0.0012 18.7 3.7 2.9 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) 2-oxoacid_dh PF00198.18 ESS66534.1 - 7.3e-76 254.4 0.0 1.1e-75 253.8 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 ESS66534.1 - 1.2e-13 50.5 0.5 3e-13 49.2 0.4 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 ESS66534.1 - 7.5e-11 41.4 1.8 2.2e-10 39.9 0.6 2.3 2 0 0 2 2 2 1 e3 binding domain DUF3614 PF12267.3 ESS66534.1 - 0.022 15.0 0.1 0.29 11.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3614) PA_decarbox PF05870.6 ESS66534.1 - 0.097 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) Semialdhyde_dh PF01118.19 ESS66535.1 - 0.0017 18.6 0.0 0.0038 17.5 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 ESS66535.1 - 0.0076 16.2 0.0 0.098 12.6 0.0 2.6 2 1 0 2 2 2 1 NADH(P)-binding DapB_N PF01113.15 ESS66535.1 - 0.038 13.8 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 ESS66535.1 - 0.073 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Methyltransf_11 PF08241.7 ESS66536.1 - 9.4e-15 54.8 1.4 3.6e-11 43.3 0.0 3.0 3 1 1 4 4 4 2 Methyltransferase domain Methyltransf_23 PF13489.1 ESS66536.1 - 8.4e-11 41.8 0.0 1.3e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS66536.1 - 3.9e-10 40.3 1.9 4.1e-07 30.5 0.5 3.4 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS66536.1 - 3.4e-08 33.7 0.7 1.8e-07 31.4 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS66536.1 - 3.7e-08 33.7 0.5 2e-07 31.3 0.2 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS66536.1 - 2.4e-07 30.4 0.0 1.9e-06 27.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS66536.1 - 2.8e-07 30.5 1.0 6.1e-07 29.4 0.3 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS66536.1 - 0.00011 21.4 0.0 0.00017 20.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 ESS66536.1 - 0.00089 18.0 0.0 0.024 13.3 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1698) TPR_2 PF07719.12 ESS66537.1 - 0.046 13.6 0.4 0.16 11.9 0.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Zeta_toxin PF06414.7 ESS66537.1 - 0.087 11.9 0.3 5.4 6.0 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin PIP5K PF01504.13 ESS66538.1 - 8.5e-65 218.3 0.0 1.3e-64 217.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Pkinase PF00069.20 ESS66539.1 - 4e-28 98.2 0.0 3.6e-27 95.1 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66539.1 - 1.2e-10 40.9 0.0 3.9e-08 32.6 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESS66539.1 - 0.16 10.9 0.0 0.42 9.6 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UDPG_MGDP_dh_N PF03721.9 ESS66540.1 - 7.5e-48 162.3 0.5 1.6e-47 161.2 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 ESS66540.1 - 1.9e-36 124.4 0.2 6.7e-36 122.6 0.1 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 ESS66540.1 - 9.9e-30 102.6 0.0 1.9e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Saccharop_dh PF03435.13 ESS66540.1 - 0.0037 16.2 0.0 0.006 15.6 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase VRR_NUC PF08774.6 ESS66541.1 - 3.3e-18 65.5 0.0 1.3e-17 63.6 0.0 2.0 2 0 0 2 2 2 1 VRR-NUC domain HECT PF00632.20 ESS66541.1 - 0.18 10.9 0.1 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) Mur_ligase_M PF08245.7 ESS66542.1 - 6.8e-10 39.2 0.0 2.4e-09 37.5 0.0 1.8 1 1 0 1 1 1 1 Mur ligase middle domain RCC1 PF00415.13 ESS66543.1 - 7.3e-24 83.7 7.0 8.5e-09 35.4 0.1 5.3 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS66543.1 - 2.3e-21 74.8 9.1 1.5e-06 27.6 0.0 4.4 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Fibrillarin PF01269.12 ESS66544.1 - 4.7e-106 352.8 0.0 5.6e-106 352.6 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 ESS66544.1 - 6e-05 22.6 0.0 0.00011 21.8 0.0 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 ESS66544.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cullin PF00888.17 ESS66545.1 - 1.6e-76 258.1 7.3 2e-76 257.7 5.1 1.0 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESS66545.1 - 7.2e-09 35.3 0.0 4.9e-08 32.6 0.0 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain HbrB PF08539.6 ESS66545.1 - 0.0005 19.9 1.1 0.0011 18.8 0.7 1.6 1 0 0 1 1 1 1 HbrB-like Ribosomal_L11 PF00298.14 ESS66545.1 - 0.019 15.1 0.3 1.6 8.9 0.0 2.9 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain HTH_20 PF12840.2 ESS66545.1 - 0.025 14.3 0.1 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Adap_comp_sub PF00928.16 ESS66546.1 - 7.1e-61 205.5 0.0 8.7e-61 205.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESS66546.1 - 0.00027 20.6 0.2 0.00064 19.4 0.2 1.6 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RNase_PH PF01138.16 ESS66547.1 - 1.3e-25 90.2 0.7 1.8e-25 89.7 0.5 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 rRNA_proc-arch PF13234.1 ESS66548.1 - 3.8e-52 177.0 0.7 6.4e-52 176.3 0.5 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 ESS66548.1 - 1.9e-51 173.8 1.9 2.9e-51 173.2 0.1 2.2 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.24 ESS66548.1 - 8.5e-24 83.9 0.0 6.6e-23 81.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS66548.1 - 4.7e-07 29.5 0.0 1.9e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS66548.1 - 0.00022 21.1 0.0 0.001 18.9 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESS66548.1 - 0.00056 19.6 0.0 0.0017 18.0 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain Zot PF05707.7 ESS66548.1 - 0.0014 18.1 0.0 0.007 15.8 0.0 2.1 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) PhoH PF02562.11 ESS66548.1 - 0.0076 15.5 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein Arch_ATPase PF01637.13 ESS66548.1 - 0.063 12.9 0.0 0.063 12.9 0.0 2.6 3 0 0 3 3 3 0 Archaeal ATPase CobA_CobO_BtuR PF02572.10 ESS66548.1 - 0.067 12.8 0.4 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP RMMBL PF07521.7 ESS66548.1 - 0.078 12.8 0.0 2.3 8.1 0.0 2.8 2 0 0 2 2 2 0 RNA-metabolising metallo-beta-lactamase DUF1664 PF07889.7 ESS66548.1 - 0.4 10.4 2.1 2.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) GTP1_OBG PF01018.17 ESS66549.1 - 2.6e-37 127.8 4.9 3.7e-37 127.3 3.4 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.18 ESS66549.1 - 1.3e-16 60.5 0.0 2.4e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS66549.1 - 2.4e-06 26.9 0.0 2.6e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.16 ESS66549.1 - 0.0042 16.3 0.0 0.039 13.2 0.0 2.3 2 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESS66549.1 - 0.062 12.7 0.0 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ATP-grasp_2 PF08442.5 ESS66550.1 - 1.7e-39 135.3 0.0 3.4e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 ESS66550.1 - 1.4e-24 86.4 0.2 3.2e-24 85.2 0.1 1.6 2 0 0 2 2 2 1 CoA-ligase SelP_N PF04592.9 ESS66551.1 - 0.57 9.5 6.8 0.56 9.5 4.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.17 ESS66551.1 - 2 7.3 6.5 2.2 7.2 4.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter ERbeta_N PF12497.3 ESS66552.1 - 0.049 13.4 0.2 0.055 13.3 0.1 1.1 1 0 0 1 1 1 0 Estrogen receptor beta NUC194 PF08163.7 ESS66555.1 - 2.6e-23 82.5 0.0 1e-10 41.0 0.0 2.1 2 0 0 2 2 2 2 NUC194 domain ENTH PF01417.15 ESS66556.1 - 2.2e-07 30.7 0.0 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 2 ENTH domain ANTH PF07651.11 ESS66556.1 - 0.0027 16.4 0.1 0.21 10.2 0.0 2.2 2 0 0 2 2 2 2 ANTH domain zf-RING_2 PF13639.1 ESS66557.1 - 3.9e-15 55.4 7.3 6.9e-15 54.5 5.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESS66557.1 - 6.9e-09 35.6 2.4 1.5e-08 34.5 1.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 ESS66557.1 - 7.2e-08 32.0 5.1 1.2e-07 31.2 3.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESS66557.1 - 1.6e-07 30.8 4.3 2.9e-07 30.0 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS66557.1 - 6.2e-07 29.3 7.6 1.2e-06 28.4 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS66557.1 - 1.3e-05 24.7 5.9 2.2e-05 24.0 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS66557.1 - 6.4e-05 22.7 1.3 0.00016 21.4 0.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ESS66557.1 - 0.017 14.7 3.3 0.025 14.2 1.7 1.7 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESS66557.1 - 0.071 12.9 3.4 0.19 11.6 2.4 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 ESS66557.1 - 0.29 11.1 5.8 1 9.3 4.0 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.1 ESS66557.1 - 0.33 10.5 5.3 0.61 9.7 3.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 ESS66557.1 - 0.8 9.7 6.8 1.8 8.6 4.7 1.5 1 0 0 1 1 1 0 RING-variant domain RED_C PF07807.6 ESS66558.1 - 0.21 11.7 1.0 1.7 8.8 0.2 2.2 2 0 0 2 2 2 0 RED-like protein C-terminal region PX PF00787.19 ESS66559.1 - 4.4e-24 84.4 0.1 3.1e-11 43.0 0.0 3.1 3 0 0 3 3 3 2 PX domain AAA_16 PF13191.1 ESS66560.1 - 2.6e-06 27.5 2.9 4.3e-06 26.8 0.4 2.6 2 2 0 2 2 2 1 AAA ATPase domain MCM PF00493.18 ESS66560.1 - 9.9e-06 24.5 0.0 1.6e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family G-alpha PF00503.15 ESS66560.1 - 0.012 14.2 0.0 0.026 13.2 0.0 1.4 2 0 0 2 2 2 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.13 ESS66560.1 - 0.025 14.0 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 ESS66560.1 - 0.028 13.9 0.0 0.1 12.1 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane PF01061.19 ESS66561.1 - 1.1e-38 132.5 17.0 1.9e-38 131.7 11.8 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESS66561.1 - 2.5e-25 89.3 0.0 3.6e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS66561.1 - 7.8e-09 35.8 0.1 0.00052 20.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 ESS66561.1 - 0.00024 20.3 0.1 0.00083 18.5 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESS66561.1 - 0.00024 20.5 0.0 0.00059 19.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 ESS66561.1 - 0.00082 18.6 0.0 0.0064 15.7 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 ESS66561.1 - 0.0029 17.8 0.0 0.0054 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS66561.1 - 0.0034 17.4 0.0 0.0063 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESS66561.1 - 0.0048 17.6 0.0 0.011 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESS66561.1 - 0.0093 15.3 0.1 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 ESS66561.1 - 0.01 14.5 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESS66561.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESS66561.1 - 0.015 15.2 0.1 0.044 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESS66561.1 - 0.05 13.4 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 ESS66561.1 - 0.053 13.4 0.1 0.35 10.7 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.12 ESS66561.1 - 0.056 13.2 0.3 0.1 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 ABC2_membrane_3 PF12698.2 ESS66561.1 - 0.066 12.2 18.1 0.0064 15.5 9.0 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein AAA_23 PF13476.1 ESS66561.1 - 0.092 13.0 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESS66561.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC2_membrane_2 PF12679.2 ESS66561.1 - 0.14 10.9 9.6 0.006 15.4 2.4 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein Motile_Sperm PF00635.21 ESS66562.1 - 3.9e-12 45.7 0.0 0.067 12.8 0.0 7.7 8 0 0 8 8 8 3 MSP (Major sperm protein) domain MYCBPAP PF14646.1 ESS66562.1 - 0.0092 14.7 0.0 2 7.0 0.0 3.2 4 0 0 4 4 4 2 MYCBP-associated protein family PAP_assoc PF03828.14 ESS66563.1 - 2.1e-14 53.2 0.0 4.7e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase BRF1 PF07741.8 ESS66564.1 - 0.0036 17.5 1.3 0.0043 17.2 0.9 1.2 1 0 0 1 1 1 1 Brf1-like TBP-binding domain EzrA PF06160.7 ESS66564.1 - 0.005 15.0 1.8 0.0051 15.0 1.2 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4407 PF14362.1 ESS66564.1 - 0.013 14.5 1.7 0.015 14.2 1.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TRAP-gamma PF07074.7 ESS66564.1 - 0.022 14.2 0.6 0.025 14.0 0.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) CENP-Q PF13094.1 ESS66564.1 - 0.071 13.1 4.0 0.089 12.8 2.8 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit CR6_interact PF10147.4 ESS66564.1 - 0.075 12.3 7.4 0.088 12.1 5.2 1.1 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Erp_C PF06780.6 ESS66564.1 - 0.092 12.5 2.7 0.12 12.1 1.9 1.1 1 0 0 1 1 1 0 Erp protein C-terminus HCMV_UL139 PF12507.3 ESS66564.1 - 0.12 12.5 2.4 0.16 12.1 1.7 1.1 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein Prominin PF05478.6 ESS66564.1 - 0.12 9.8 0.9 0.13 9.7 0.7 1.0 1 0 0 1 1 1 0 Prominin SlyX PF04102.7 ESS66564.1 - 0.14 12.5 5.7 0.8 10.1 3.6 1.9 1 1 0 1 1 1 0 SlyX Mnd1 PF03962.10 ESS66564.1 - 0.14 11.7 4.0 0.15 11.7 2.8 1.1 1 0 0 1 1 1 0 Mnd1 family HemX PF04375.9 ESS66564.1 - 0.15 10.6 1.1 0.14 10.7 0.8 1.0 1 0 0 1 1 1 0 HemX DUF972 PF06156.8 ESS66564.1 - 0.15 12.3 3.2 0.21 11.9 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) BLOC1_2 PF10046.4 ESS66564.1 - 0.16 12.0 2.8 0.21 11.7 1.9 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 V_ATPase_I PF01496.14 ESS66564.1 - 0.24 9.2 1.1 0.23 9.2 0.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OmpH PF03938.9 ESS66564.1 - 0.28 11.1 3.9 0.31 10.9 2.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1664 PF07889.7 ESS66564.1 - 0.29 10.9 1.5 0.37 10.5 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IncA PF04156.9 ESS66564.1 - 0.3 10.6 6.0 0.49 9.9 4.2 1.3 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 ESS66564.1 - 0.34 9.9 5.1 0.35 9.8 3.5 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 UPF0242 PF06785.6 ESS66564.1 - 0.62 8.6 2.9 0.68 8.5 2.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) EAP30 PF04157.11 ESS66564.1 - 0.73 8.9 4.9 0.81 8.7 2.0 1.7 1 1 1 2 2 2 0 EAP30/Vps36 family bZIP_1 PF00170.16 ESS66564.1 - 3.1 7.8 9.1 1.7 8.6 4.7 1.7 1 1 1 2 2 2 0 bZIP transcription factor Spc24 PF08286.6 ESS66564.1 - 5.7 6.6 6.9 10 5.8 4.8 1.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Peptidase_S28 PF05577.7 ESS66565.1 - 7.3e-58 196.1 0.5 1.2e-57 195.4 0.3 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.16 ESS66565.1 - 5.9e-06 25.6 0.1 1.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S37 PF05576.6 ESS66565.1 - 1.6e-05 23.5 0.1 2.3e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 PS-10 peptidase S37 Abhydrolase_1 PF00561.15 ESS66565.1 - 0.00015 21.4 0.0 0.00021 20.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ESS66565.1 - 0.00018 21.4 0.0 0.00045 20.1 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.15 ESS66565.1 - 0.016 14.6 0.0 0.035 13.5 0.0 1.6 1 1 0 1 1 1 0 Putative esterase Phytochelatin PF05023.9 ESS66567.1 - 5.3e-08 32.0 0.0 0.0041 16.1 0.0 2.5 2 0 0 2 2 2 2 Phytochelatin synthase OB_NTP_bind PF07717.11 ESS66568.1 - 1.6e-26 92.3 0.0 5.5e-26 90.6 0.0 1.9 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESS66568.1 - 1.2e-20 73.3 0.0 3.4e-20 71.9 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS66568.1 - 1.3e-11 44.1 0.0 4.1e-11 42.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS66568.1 - 1.8e-08 34.0 0.1 4.4e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS66568.1 - 7.4e-06 26.1 0.9 2.1e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 ESS66568.1 - 0.038 13.4 0.1 0.15 11.5 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.1 ESS66568.1 - 0.046 13.4 0.1 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 ESS66568.1 - 0.064 13.0 0.1 9.7 5.9 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.1 ESS66568.1 - 0.1 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.14 ESS66568.1 - 0.15 11.5 0.0 0.34 10.3 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Zot PF05707.7 ESS66568.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_23 PF13476.1 ESS66568.1 - 0.9 9.8 0.0 0.9 9.8 0.0 2.5 2 1 0 2 2 1 0 AAA domain AAA_5 PF07728.9 ESS66570.1 - 0.055 13.1 0.0 0.14 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2891 PF11199.3 ESS66570.1 - 0.2 10.2 0.0 0.29 9.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) NDK PF00334.14 ESS66572.1 - 5.2e-16 58.6 0.0 0.043 13.6 0.0 11.5 13 0 0 13 13 13 3 Nucleoside diphosphate kinase EF-hand_7 PF13499.1 ESS66572.1 - 0.078 13.1 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.1 ESS66572.1 - 0.15 11.6 0.0 0.5 10.0 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.27 ESS66572.1 - 0.2 11.0 0.0 0.6 9.5 0.0 1.9 1 0 0 1 1 1 0 EF hand TP6A_N PF04406.9 ESS66573.1 - 9.3e-10 38.0 0.1 1.8e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.5 ESS66573.1 - 0.095 12.5 0.0 0.23 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2399) DUF2116 PF09889.4 ESS66573.1 - 0.17 11.7 1.5 0.49 10.2 1.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) TPR_11 PF13414.1 ESS66575.1 - 1.5e-10 40.5 2.2 6.4e-07 28.9 0.2 2.7 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 ESS66575.1 - 1.6e-06 27.5 0.4 0.042 13.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66575.1 - 1.1e-05 24.7 0.2 0.059 13.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66575.1 - 0.00012 22.6 0.4 0.00012 22.6 0.3 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS66575.1 - 0.033 14.0 2.4 1 9.2 0.4 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 ESS66575.1 - 0.16 11.9 3.7 2.8 7.8 0.4 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.1 ESS66575.1 - 0.16 11.8 0.8 7.8 6.4 0.1 2.6 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.1 ESS66575.1 - 0.74 10.6 10.5 0.083 13.5 0.5 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat U1snRNP70_N PF12220.3 ESS66575.1 - 3.1 8.1 7.2 0.5 10.7 1.6 2.3 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Bromodomain PF00439.20 ESS66578.1 - 3.4e-20 71.7 0.0 7.5e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Cwf_Cwc_15 PF04889.7 ESS66578.1 - 0.034 13.8 17.1 0.042 13.5 11.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BTV_NS2 PF04514.7 ESS66578.1 - 0.34 9.7 9.6 0.43 9.4 6.6 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 BUD22 PF09073.5 ESS66578.1 - 0.53 9.2 20.9 0.72 8.8 14.5 1.2 1 0 0 1 1 1 0 BUD22 Vfa1 PF08432.5 ESS66578.1 - 0.77 9.7 12.2 1.5 8.8 8.4 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Astro_capsid PF03115.9 ESS66578.1 - 1.9 6.6 6.9 1.9 6.6 4.8 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF3449 PF11931.3 ESS66578.1 - 2 7.8 7.4 3.2 7.1 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Fmp27 PF10344.4 ESS66578.1 - 2.1 5.8 9.5 2.7 5.5 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 RNA_pol_3_Rpc31 PF11705.3 ESS66578.1 - 3.4 7.5 31.7 5.2 6.9 22.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.9 ESS66578.1 - 7.4 4.4 20.3 11 3.9 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein RRM_1 PF00076.17 ESS66579.1 - 5.3e-08 32.3 0.0 7e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66579.1 - 7.3e-06 25.8 0.0 9.8e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS66579.1 - 1.5e-05 24.7 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 ESS66589.1 - 3.3e-06 26.7 5.2 0.79 9.7 0.0 5.4 7 0 0 7 7 7 3 WD domain, G-beta repeat IKI3 PF04762.7 ESS66589.1 - 0.2 9.4 1.6 0.68 7.6 0.2 2.2 1 1 2 3 3 3 0 IKI3 family LRR_6 PF13516.1 ESS66590.1 - 9.4e-07 28.2 0.8 0.11 12.6 0.0 3.8 4 0 0 4 4 4 2 Leucine Rich repeat LRR_7 PF13504.1 ESS66590.1 - 0.019 15.0 1.1 8.3 7.1 0.2 3.3 2 0 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.2 ESS66590.1 - 0.041 13.5 1.9 5.5 6.7 1.4 3.1 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS66590.1 - 0.22 11.6 7.8 3.4 8.0 0.1 3.6 4 1 0 4 4 4 0 Leucine Rich Repeat Tropomyosin_1 PF12718.2 ESS66591.1 - 0.00028 20.7 1.7 0.00028 20.7 1.1 8.0 4 2 3 8 8 8 2 Tropomyosin like NPV_P10 PF05531.7 ESS66591.1 - 0.012 15.8 1.0 0.012 15.8 0.7 7.8 9 1 1 10 10 10 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 ESS66591.1 - 0.032 14.3 0.7 0.032 14.3 0.5 8.0 5 2 3 8 8 8 0 Fibrinogen alpha/beta chain family Reo_sigmaC PF04582.7 ESS66591.1 - 1.4 8.0 28.6 0.88 8.6 1.5 5.9 4 1 2 6 6 6 0 Reovirus sigma C capsid protein BssS PF13991.1 ESS66592.1 - 0.077 12.7 0.2 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 BssS protein family GTP_EFTU PF00009.22 ESS66593.1 - 7.3e-10 38.5 0.0 1.1e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESS66593.1 - 0.0018 17.4 0.2 0.0044 16.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 ESS66593.1 - 0.0047 17.4 0.3 0.054 13.9 0.2 2.3 1 1 0 1 1 1 1 Miro-like protein AAA_29 PF13555.1 ESS66593.1 - 0.0083 15.6 0.1 0.019 14.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESS66593.1 - 0.011 16.0 0.1 0.018 15.3 0.1 1.3 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.12 ESS66593.1 - 0.024 14.1 0.9 1.4 8.3 0.2 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 ESS66593.1 - 0.051 13.5 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.12 ESS66593.1 - 0.053 13.3 0.1 0.085 12.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_10 PF12846.2 ESS66593.1 - 0.068 12.5 0.2 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain MobB PF03205.9 ESS66593.1 - 0.085 12.5 0.4 0.22 11.2 0.2 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 ESS66593.1 - 0.12 12.2 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESS66593.1 - 0.15 12.8 0.2 0.36 11.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain Sec7 PF01369.15 ESS66596.1 - 9.2e-51 172.2 0.0 2.2e-50 170.9 0.0 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESS66596.1 - 3.5e-05 23.2 4.8 0.0046 16.4 0.1 3.4 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_11 PF13414.1 ESS66597.1 - 7.4e-32 108.8 21.1 1.9e-14 53.0 1.6 5.0 4 2 1 5 5 4 4 TPR repeat TPR_1 PF00515.23 ESS66597.1 - 3.1e-20 70.8 27.3 2.6e-05 23.6 0.0 8.5 9 0 0 9 9 9 5 Tetratricopeptide repeat DnaJ PF00226.26 ESS66597.1 - 5.4e-20 70.8 0.2 1.6e-19 69.3 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 ESS66597.1 - 2.4e-18 64.4 25.0 0.0053 16.5 0.0 9.4 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66597.1 - 2e-11 44.2 11.5 0.067 13.8 0.3 6.4 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66597.1 - 3.3e-09 36.9 13.0 0.057 13.7 0.0 6.2 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66597.1 - 1.4e-07 31.3 14.8 0.00048 19.9 0.5 6.2 4 2 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS66597.1 - 3.1e-06 26.9 7.0 9.1 6.7 0.1 6.7 6 1 1 7 7 7 1 Tetratricopeptide repeat Rapsyn_N PF10579.4 ESS66597.1 - 4e-06 26.5 0.4 6.2e-05 22.7 0.1 2.9 3 0 0 3 3 3 1 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.1 ESS66597.1 - 2.1e-05 24.7 14.8 2.7 8.8 0.0 8.0 4 3 5 9 9 9 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS66597.1 - 0.0002 20.9 12.5 0.02 14.6 0.0 7.1 8 1 0 8 8 8 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS66597.1 - 0.00034 20.6 17.0 0.0039 17.3 0.1 4.8 3 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESS66597.1 - 0.0015 18.2 6.1 0.68 9.8 0.1 5.2 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 ESS66597.1 - 0.013 15.3 8.2 4.9 7.1 0.1 4.6 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESS66597.1 - 0.017 15.5 17.2 1.5 9.4 0.2 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS66597.1 - 0.068 13.0 0.1 0.068 13.0 0.1 5.0 5 1 1 6 6 5 0 Tetratricopeptide repeat Glycos_transf_1 PF00534.15 ESS66599.1 - 2.1e-22 79.3 0.0 2.5e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESS66599.1 - 4.9e-05 23.5 0.0 7.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESS66599.1 - 0.0001 22.4 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Aminotran_4 PF01063.14 ESS66600.1 - 5.5e-20 71.8 0.0 8.8e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class IV YopX PF09643.5 ESS66600.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 YopX protein Imm15 PF15590.1 ESS66601.1 - 0.12 11.4 0.1 0.31 10.1 0.0 1.7 2 0 0 2 2 2 0 Immunity protein 15 DUF1777 PF08648.7 ESS66602.1 - 0.037 13.7 7.3 0.048 13.4 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) TCP PF03634.8 ESS66602.1 - 4.2 7.7 8.1 0.52 10.6 2.2 1.8 1 1 1 2 2 2 0 TCP family transcription factor Pap_E4 PF02711.9 ESS66602.1 - 9.8 7.0 13.3 11 6.8 9.2 1.2 1 0 0 1 1 1 0 E4 protein CBFD_NFYB_HMF PF00808.18 ESS66603.1 - 1.4e-07 31.4 0.0 2.5e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ESS66603.1 - 0.0024 17.9 0.7 0.0043 17.1 0.5 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF2046 PF09755.4 ESS66604.1 - 0.00012 21.0 15.8 0.00012 21.0 10.9 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein H4 (DUF2046) TPR_MLP1_2 PF07926.7 ESS66604.1 - 0.0046 16.6 29.7 0.006 16.3 3.6 3.2 3 0 0 3 3 3 3 TPR/MLP1/MLP2-like protein tRNA-synt_2 PF00152.15 ESS66606.1 - 7.8e-67 225.4 0.0 1.1e-66 224.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_synt_1c_R1 PF04558.10 ESS66606.1 - 9.9e-38 129.2 0.2 1.4e-37 128.7 0.1 1.2 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_anti-codon PF01336.20 ESS66606.1 - 3e-10 39.8 0.0 5.8e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Cofilin_ADF PF00241.15 ESS66608.1 - 3.9e-14 52.6 0.0 2.1e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein ATPgrasp_Ter PF15632.1 ESS66608.1 - 0.023 13.4 0.2 0.95 8.1 0.0 2.4 2 1 1 3 3 3 0 ATP-grasp in the biosynthetic pathway with Ter operon TPR_12 PF13424.1 ESS66609.1 - 8.4e-06 25.6 4.4 0.001 18.9 1.9 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66609.1 - 0.00011 21.8 4.3 0.44 10.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS66609.1 - 0.0034 16.9 5.7 0.18 11.4 0.0 3.2 2 2 1 3 3 3 2 TPR repeat TPR_8 PF13181.1 ESS66609.1 - 0.0056 16.3 2.3 2.1 8.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66609.1 - 0.0085 16.6 2.2 13 6.7 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS66609.1 - 0.038 14.1 1.9 0.13 12.3 0.8 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.13 ESS66609.1 - 0.06 13.2 1.6 4.8 7.1 0.0 2.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESS66609.1 - 1.3 9.5 4.5 51 4.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66609.1 - 4 7.2 8.6 8.8 6.1 1.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Dynamin_N PF00350.18 ESS66611.1 - 6.7e-18 65.0 0.0 4.7e-17 62.3 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESS66611.1 - 6.6e-08 32.5 0.0 1.4e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase HA2 PF04408.18 ESS66612.1 - 8.9e-20 70.6 0.0 1.7e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESS66612.1 - 3.6e-15 55.7 0.0 4.2e-14 52.3 0.0 2.4 2 1 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESS66612.1 - 1.4e-10 40.9 0.0 5e-10 39.1 0.0 2.0 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS66612.1 - 5.8e-09 35.6 0.1 1.4e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS66612.1 - 4.1e-06 26.9 0.0 9.7e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 ESS66612.1 - 7e-06 25.9 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit T2SE PF00437.15 ESS66612.1 - 7e-05 21.8 0.0 0.00029 19.8 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein SRP54 PF00448.17 ESS66612.1 - 0.002 17.5 0.3 0.0054 16.1 0.2 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain IstB_IS21 PF01695.12 ESS66612.1 - 0.0077 15.6 0.0 1.2 8.5 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein UPF0079 PF02367.12 ESS66612.1 - 0.0083 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 Zeta_toxin PF06414.7 ESS66612.1 - 0.01 14.9 0.0 0.02 13.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.24 ESS66612.1 - 0.012 15.7 0.6 0.14 12.3 0.4 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESS66612.1 - 0.024 14.4 0.1 0.069 12.9 0.1 1.8 1 0 0 1 1 1 0 Part of AAA domain KaiC PF06745.8 ESS66612.1 - 0.025 13.7 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.1 ESS66612.1 - 0.033 13.7 0.0 0.08 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 ESS66612.1 - 0.043 13.1 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 ESS66612.1 - 0.076 12.4 0.1 8 5.8 0.0 3.2 4 0 0 4 4 3 0 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activ_2 PF14532.1 ESS66612.1 - 0.12 12.4 0.1 0.83 9.7 0.0 2.3 3 0 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.22 ESS66612.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Kelch_5 PF13854.1 ESS66613.1 - 5.8e-16 58.0 5.5 0.00045 20.1 0.2 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ESS66613.1 - 6.7e-14 51.3 16.8 0.0006 19.5 0.1 6.9 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS66613.1 - 6.5e-12 45.2 12.0 0.00014 21.8 0.1 7.7 9 0 0 9 9 9 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESS66613.1 - 9.1e-12 44.3 4.8 3.2e-05 23.3 0.1 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESS66613.1 - 1.3e-09 37.7 9.3 0.00047 20.2 0.1 5.4 4 2 2 6 6 6 2 Kelch motif Kelch_2 PF07646.10 ESS66613.1 - 1.4e-08 34.1 3.2 0.37 10.6 0.1 6.0 6 0 0 6 6 6 3 Kelch motif Glyco_hydro_65m PF03632.10 ESS66614.1 - 1.6e-29 102.7 0.0 2.5e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 ESS66614.1 - 0.061 12.6 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain MASE2 PF05230.6 ESS66614.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 MASE2 domain HAD_2 PF13419.1 ESS66615.1 - 3.6e-07 30.5 0.1 6.6e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Glyco_hydro_65C PF03633.10 ESS66615.1 - 7.9e-06 25.8 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain Exo_endo_phos PF03372.18 ESS66616.1 - 3.7e-19 69.6 0.0 5.2e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SET PF00856.23 ESS66617.1 - 2.2e-07 31.3 0.0 4.7e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 SET domain CorA PF01544.13 ESS66618.1 - 6e-19 68.1 0.1 9.9e-19 67.4 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Thioredoxin PF00085.15 ESS66619.1 - 2.5e-27 94.6 0.0 1.1e-25 89.3 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 ESS66619.1 - 2.8e-08 33.9 0.1 9e-06 25.8 0.0 3.1 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESS66619.1 - 2.9e-07 30.5 0.0 3.6e-05 23.8 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_6 PF13848.1 ESS66619.1 - 0.00021 21.1 0.3 0.17 11.6 0.0 3.2 2 1 0 3 3 3 1 Thioredoxin-like domain Redoxin PF08534.5 ESS66619.1 - 0.0003 20.3 0.0 0.00068 19.1 0.0 1.6 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.1 ESS66619.1 - 0.0085 15.6 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 ESS66619.1 - 0.0093 15.9 0.0 0.034 14.1 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_4 PF13462.1 ESS66619.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Pkinase PF00069.20 ESS66620.1 - 9.1e-47 159.3 0.0 6.1e-30 104.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66620.1 - 3.8e-27 95.0 0.0 5e-21 74.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DSPc PF00782.15 ESS66620.1 - 7.4e-26 90.3 0.0 1.5e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.2 ESS66620.1 - 5.5e-16 57.7 14.6 6.8e-09 35.1 0.9 4.6 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS66620.1 - 6.4e-12 45.0 6.0 1.7e-08 34.1 2.3 3.7 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESS66620.1 - 4.2e-11 41.2 5.4 0.051 13.6 0.0 6.1 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 ESS66620.1 - 4.5e-07 29.0 3.1 0.4 11.0 0.1 5.5 6 0 0 6 6 5 2 Leucine rich repeat Kinase-like PF14531.1 ESS66620.1 - 2.4e-05 23.4 0.0 0.021 13.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Y_phosphatase PF00102.22 ESS66620.1 - 0.0087 15.4 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Kdo PF06293.9 ESS66620.1 - 0.019 14.0 0.2 3.6 6.6 0.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDKN3 PF05706.7 ESS66620.1 - 0.068 12.6 0.1 2.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) LRR_6 PF13516.1 ESS66620.1 - 0.068 13.2 4.4 14 6.0 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeat HEAT_2 PF13646.1 ESS66621.1 - 0.0076 16.5 3.0 0.13 12.5 0.0 3.4 2 1 1 3 3 3 1 HEAT repeats OGG_N PF07934.7 ESS66622.1 - 3.3e-25 88.3 0.0 6.9e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 ESS66622.1 - 8e-12 45.4 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 ESS66622.1 - 3e-06 26.5 0.1 1.9e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.1 ESS66622.1 - 0.054 13.6 0.0 7.1 6.8 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix domain Cgr1 PF03879.9 ESS66623.1 - 0.07 13.3 2.7 0.22 11.7 1.9 1.8 1 0 0 1 1 1 0 Cgr1 family YbjQ_1 PF01906.12 ESS66623.1 - 0.15 12.4 0.1 0.35 11.3 0.1 1.6 1 0 0 1 1 1 0 Putative heavy-metal-binding DUF3280 PF11684.3 ESS66623.1 - 0.3 11.2 2.4 13 5.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2380) Pox_A_type_inc PF04508.7 ESS66623.1 - 6.6 6.7 11.3 0.71 9.8 0.8 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat CcmD PF04995.9 ESS66624.1 - 0.24 11.1 2.6 0.58 9.9 1.8 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) ABC2_membrane_2 PF12679.2 ESS66624.1 - 6.8 5.4 8.2 8.2 5.2 5.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Pkinase PF00069.20 ESS66625.1 - 3.6e-36 124.6 0.0 1.5e-35 122.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66625.1 - 7.2e-22 77.6 0.0 2.4e-19 69.4 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS66625.1 - 0.0011 18.0 0.0 0.039 12.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESS66625.1 - 0.091 12.4 0.0 0.34 10.5 0.0 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family ABC_tran PF00005.22 ESS66627.1 - 1.6e-44 151.5 0.0 7e-26 91.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 ESS66627.1 - 3.9e-42 144.5 27.8 2.7e-22 79.4 6.8 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 ESS66627.1 - 1.1e-10 41.1 0.1 0.002 17.4 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESS66627.1 - 8.1e-08 32.5 1.7 0.63 9.9 0.0 4.4 4 0 0 4 4 4 2 AAA domain AAA_25 PF13481.1 ESS66627.1 - 3e-06 26.7 0.1 0.0034 16.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESS66627.1 - 3.7e-06 26.3 0.1 0.051 13.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ESS66627.1 - 9.7e-05 21.6 0.1 0.17 11.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS66627.1 - 0.00033 20.6 0.1 0.025 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 ESS66627.1 - 0.00035 20.5 0.0 0.23 11.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 ESS66627.1 - 0.00039 19.9 0.2 0.67 9.3 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family IstB_IS21 PF01695.12 ESS66627.1 - 0.00057 19.3 0.4 5.3 6.4 0.0 3.5 3 0 0 3 3 3 1 IstB-like ATP binding protein DUF87 PF01935.12 ESS66627.1 - 0.00073 19.4 1.0 1 9.1 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function DUF87 Miro PF08477.8 ESS66627.1 - 0.0012 19.3 0.1 1.2 9.6 0.0 2.6 2 0 0 2 2 2 1 Miro-like protein AAA_23 PF13476.1 ESS66627.1 - 0.0018 18.6 0.0 0.82 9.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 ESS66627.1 - 0.0059 16.4 1.7 0.16 11.7 0.1 2.5 2 0 0 2 2 2 1 Dynamin family AAA_17 PF13207.1 ESS66627.1 - 0.0076 17.0 0.0 1.4 9.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain Pox_A32 PF04665.7 ESS66627.1 - 0.02 14.2 0.4 2.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein NACHT PF05729.7 ESS66627.1 - 0.02 14.5 0.3 0.14 11.8 0.0 2.4 2 0 0 2 2 2 0 NACHT domain MobB PF03205.9 ESS66627.1 - 0.048 13.3 0.0 3.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B IIGP PF05049.8 ESS66627.1 - 0.079 11.7 0.1 2.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_19 PF13245.1 ESS66627.1 - 0.082 12.6 0.5 1.8 8.4 0.0 3.2 3 0 0 3 3 3 0 Part of AAA domain AAA_33 PF13671.1 ESS66627.1 - 0.1 12.5 0.0 0.87 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESS66627.1 - 0.1 12.0 0.7 3.2 7.0 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_22 PF13401.1 ESS66627.1 - 0.13 12.4 0.1 5.4 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESS66627.1 - 0.45 9.5 0.2 5.1 6.1 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin DUF3483 PF11982.3 ESS66628.1 - 0.048 12.9 0.5 0.074 12.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3483) PLDc_2 PF13091.1 ESS66629.1 - 1.2e-25 89.6 0.0 2.9e-17 62.6 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 ESS66629.1 - 3.1e-11 42.6 3.2 4.2e-06 26.3 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif DUF1079 PF06435.6 ESS66630.1 - 0.059 13.3 0.1 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Repeat of unknown function (DUF1079) PAM2 PF07145.10 ESS66634.1 - 0.078 12.5 0.0 0.24 10.9 0.0 1.9 1 0 0 1 1 1 0 Ataxin-2 C-terminal region DUF4551 PF15087.1 ESS66636.1 - 1.1 7.4 7.8 1.2 7.3 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MIP-T3 PF10243.4 ESS66636.1 - 6.1 5.1 26.7 6.4 5.1 18.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Pkinase PF00069.20 ESS66637.1 - 7.9e-58 195.6 0.0 9.2e-58 195.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66637.1 - 3.3e-28 98.4 0.0 6.2e-28 97.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS66637.1 - 0.0033 16.4 0.0 0.005 15.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 ESS66637.1 - 0.076 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WEMBL PF05701.6 ESS66638.1 - 0.0095 14.4 12.6 0.015 13.7 8.7 1.2 1 0 0 1 1 1 1 Weak chloroplast movement under blue light CCDC-167 PF15188.1 ESS66638.1 - 0.035 14.0 10.0 0.043 13.7 1.3 2.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 IFP_35_N PF07334.8 ESS66638.1 - 0.11 12.4 7.0 0.25 11.3 3.9 2.4 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus MscS_porin PF12795.2 ESS66638.1 - 1.4 8.2 17.6 0.088 12.1 7.2 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Tropomyosin_1 PF12718.2 ESS66638.1 - 4.6 7.0 21.1 0.36 10.6 10.8 1.9 2 0 0 2 2 2 0 Tropomyosin like FtsX PF02687.16 ESS66639.1 - 7.6e-31 106.3 66.3 1.6e-18 66.6 9.4 5.4 5 0 0 5 5 5 3 FtsX-like permease family MacB_PCD PF12704.2 ESS66639.1 - 2.5e-06 27.2 4.8 0.00048 19.7 0.1 5.6 5 1 0 5 5 5 2 MacB-like periplasmic core domain SIR2 PF02146.12 ESS66642.1 - 4.9e-46 156.6 0.0 5.9e-46 156.4 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.17 ESS66642.1 - 0.092 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DoxX PF07681.7 ESS66643.1 - 0.00099 19.4 7.4 0.00099 19.4 5.1 1.7 2 0 0 2 2 2 1 DoxX HR_lesion PF05514.6 ESS66643.1 - 0.0069 16.2 4.1 0.0096 15.7 2.9 1.2 1 0 0 1 1 1 1 HR-like lesion-inducing DUF1858 PF08984.6 ESS66643.1 - 0.04 13.5 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) Neurensin PF14927.1 ESS66643.1 - 0.068 12.5 0.3 0.098 12.0 0.2 1.3 1 0 0 1 1 1 0 Neurensin FA_desaturase PF00487.19 ESS66643.1 - 0.091 12.1 0.8 0.11 11.9 0.6 1.2 1 0 0 1 1 1 0 Fatty acid desaturase SURF4 PF02077.10 ESS66643.1 - 0.19 11.0 1.5 0.32 10.3 0.4 1.7 1 1 2 3 3 3 0 SURF4 family DUF3487 PF11990.3 ESS66643.1 - 0.3 10.4 3.2 0.72 9.2 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) ubiquitin PF00240.18 ESS66644.1 - 1.2e-18 66.2 0.0 1.4e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESS66644.1 - 1.5e-10 40.5 0.1 1.7e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 ESS66644.1 - 0.0001 22.1 0.1 0.00045 20.0 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESS66644.1 - 0.00022 21.4 0.0 0.00062 19.9 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.4 ESS66644.1 - 0.054 13.6 0.0 0.066 13.4 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain ResIII PF04851.10 ESS66650.1 - 1.9e-15 57.1 0.0 3.5e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T5orf172 PF10544.4 ESS66650.1 - 1.2e-09 38.4 0.0 3.1e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 T5orf172 domain DEAD PF00270.24 ESS66650.1 - 3.9e-07 29.7 0.0 6.8e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase MUG113 PF13455.1 ESS66650.1 - 2.1e-05 24.8 0.3 0.00023 21.5 0.0 2.7 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 Helicase_C PF00271.26 ESS66650.1 - 0.0003 20.5 0.0 0.001 18.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3505 PF12013.3 ESS66650.1 - 2 8.6 8.7 0.1 12.8 1.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3505) Methyltransf_23 PF13489.1 ESS66651.1 - 7.1e-15 55.0 0.0 1.1e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS66651.1 - 1.7e-10 41.2 0.0 6.9e-10 39.3 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS66651.1 - 1.7e-10 40.7 0.1 3.1e-06 26.8 0.0 2.5 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 ESS66651.1 - 5.5e-09 36.5 0.0 3.1e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS66651.1 - 6.9e-09 36.0 0.0 0.0022 18.4 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 ESS66651.1 - 2.8e-05 24.3 0.0 0.00015 22.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS66651.1 - 0.00012 22.1 0.0 0.00087 19.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESS66651.1 - 0.03 13.3 0.0 1.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_32 PF13679.1 ESS66651.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GrpE PF01025.14 ESS66652.1 - 0.0088 15.6 0.8 0.91 9.0 0.0 2.4 2 0 0 2 2 2 2 GrpE ALIX_LYPXL_bnd PF13949.1 ESS66652.1 - 0.0097 14.9 1.6 0.16 10.8 0.6 2.1 1 1 1 2 2 2 1 ALIX V-shaped domain binding to HIV Tox-ODYAM1 PF15642.1 ESS66652.1 - 0.033 12.8 3.3 0.062 11.9 2.3 1.4 1 1 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Bul1_C PF04426.7 ESS66652.1 - 0.1 11.8 1.4 0.2 10.8 0.1 2.1 2 1 1 3 3 3 0 Bul1 C terminus HMG_box_5 PF14887.1 ESS66652.1 - 0.11 12.2 0.7 0.3 10.9 0.5 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box 5 BNR PF02012.15 ESS66653.1 - 0.00059 19.2 0.4 3.3 7.9 0.0 4.1 4 0 0 4 4 4 2 BNR/Asp-box repeat WD40 PF00400.27 ESS66654.1 - 6.7e-29 98.7 5.7 1.4e-09 37.4 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 ESS66654.1 - 0.00026 19.2 0.1 0.0017 16.5 0.1 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESS66654.1 - 0.041 12.6 0.0 0.1 11.3 0.0 1.6 2 0 0 2 2 2 0 Nup133 N terminal like MFS_1 PF07690.11 ESS66656.1 - 2.8e-13 49.3 34.5 2.8e-13 49.3 23.9 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESS66656.1 - 7.6e-05 21.4 9.2 7.6e-05 21.4 6.3 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter Calpain_III PF01067.17 ESS66658.1 - 1.6e-36 125.1 0.0 3.8e-08 33.1 0.0 6.7 6 2 0 6 6 6 4 Calpain large subunit, domain III Peptidase_C2 PF00648.16 ESS66658.1 - 6e-29 100.9 0.3 1e-28 100.2 0.2 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease LRR_6 PF13516.1 ESS66658.1 - 0.011 15.7 0.1 1 9.6 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat PAE PF03283.8 ESS66658.1 - 0.011 14.4 0.0 0.016 13.8 0.0 1.2 1 0 0 1 1 1 0 Pectinacetylesterase Topoisom_bac PF01131.15 ESS66659.1 - 3e-76 256.8 0.0 3.4e-75 253.3 0.0 2.2 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 ESS66659.1 - 4.4e-14 52.2 0.0 1.9e-13 50.2 0.0 2.2 2 1 0 2 2 2 1 Toprim domain Toprim_4 PF13662.1 ESS66659.1 - 0.00012 22.0 0.0 0.00056 19.8 0.0 2.1 2 0 0 2 2 2 1 Toprim domain Toprim_2 PF13155.1 ESS66659.1 - 0.076 13.3 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Toprim-like Pkinase PF00069.20 ESS66660.1 - 1.8e-52 178.0 0.0 2.8e-52 177.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66660.1 - 3.7e-32 111.4 0.0 6.1e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Guanylate_cyc PF00211.15 ESS66660.1 - 5.4e-06 25.8 0.0 9.8e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.1 ESS66660.1 - 0.011 14.6 0.0 0.024 13.6 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 ESS66660.1 - 0.02 13.9 0.0 0.042 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IncA PF04156.9 ESS66660.1 - 0.039 13.5 0.1 0.085 12.4 0.1 1.5 1 0 0 1 1 1 0 IncA protein Pkinase PF00069.20 ESS66662.1 - 2e-36 125.4 0.0 2.8e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66662.1 - 1e-14 54.2 0.0 1.3e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS66662.1 - 0.0021 17.0 0.0 0.012 14.5 0.0 2.0 1 1 0 1 1 1 1 Kinase-like LRR_6 PF13516.1 ESS66663.1 - 3.8e-21 72.7 13.9 0.033 14.2 0.0 11.3 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.2 ESS66663.1 - 2.6e-15 55.6 9.5 0.014 15.0 0.0 9.5 9 2 0 10 10 10 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS66663.1 - 2e-10 39.2 17.5 3.7 7.9 0.0 12.2 13 0 0 13 13 13 3 Leucine Rich Repeat LRR_8 PF13855.1 ESS66663.1 - 5.9e-07 29.1 30.6 2.1 8.1 0.2 10.6 7 5 3 10 10 10 6 Leucine rich repeat Cytochrom_C552 PF02335.10 ESS66663.1 - 0.14 10.8 0.2 0.2 10.2 0.2 1.1 1 0 0 1 1 1 0 Cytochrome c552 LRR_7 PF13504.1 ESS66663.1 - 0.19 12.0 37.7 8.9 7.0 0.1 11.4 12 2 1 13 13 13 0 Leucine rich repeat Mucin PF01456.12 ESS66664.1 - 0.016 15.0 3.0 0.02 14.6 2.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF599 PF04654.7 ESS66664.1 - 0.024 13.8 0.7 0.031 13.4 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF599 COG2 PF06148.6 ESS66666.1 - 0.00022 21.0 9.1 0.052 13.4 0.6 2.8 2 1 1 3 3 3 2 COG (conserved oligomeric Golgi) complex component, COG2 DDE_Tnp_ISL3 PF01610.12 ESS66666.1 - 0.05 13.1 8.6 0.076 12.5 6.0 1.3 1 0 0 1 1 1 0 Transposase ADIP PF11559.3 ESS66666.1 - 0.13 12.1 27.7 0.12 12.2 10.1 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding PilJ PF13675.1 ESS66666.1 - 0.13 12.5 16.2 0.55 10.5 2.6 2.9 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Baculo_PEP_C PF04513.7 ESS66666.1 - 0.15 11.9 1.3 4.8 7.0 0.4 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Occludin_ELL PF07303.8 ESS66666.1 - 0.27 11.9 14.0 0.14 12.8 2.1 2.5 1 1 0 2 2 2 0 Occludin homology domain Plasmid_stabil PF05016.9 ESS66666.1 - 0.77 10.1 5.1 0.46 10.9 0.2 2.4 2 1 0 2 2 2 0 Plasmid stabilisation system protein Fib_alpha PF08702.5 ESS66666.1 - 2.6 8.1 9.8 1.7 8.7 2.4 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family OrfB_IS605 PF01385.14 ESS66666.1 - 4.9 6.4 9.0 0.23 10.7 1.6 2.2 1 1 1 2 2 2 0 Probable transposase Aldedh PF00171.17 ESS66666.1 - 5.4 5.2 5.8 7 4.8 3.7 1.4 1 1 0 1 1 1 0 Aldehyde dehydrogenase family FUSC PF04632.7 ESS66666.1 - 6 5.1 15.8 3.9 5.7 9.4 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family L31 PF09784.4 ESS66666.1 - 8.5 6.5 13.6 1.5 8.9 1.9 3.0 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 LRR_6 PF13516.1 ESS66667.1 - 0.0092 15.9 0.2 57 4.2 0.0 3.7 3 0 0 3 3 3 3 Leucine Rich repeat CHAT PF12770.2 ESS66668.1 - 7e-35 120.5 0.1 1.3e-34 119.6 0.0 1.5 1 0 0 1 1 1 1 CHAT domain LRR_6 PF13516.1 ESS66669.1 - 0.067 13.2 0.2 1.5 9.0 0.1 2.8 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.2 ESS66669.1 - 0.076 12.6 0.8 13 5.5 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) MVP_shoulder PF11978.3 ESS66670.1 - 5.8e-46 155.2 0.0 1.1e-45 154.3 0.0 1.5 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.13 ESS66670.1 - 1.8e-40 136.7 0.1 3.2e-15 55.9 0.0 5.2 5 0 0 5 5 5 4 Major Vault Protein repeat AAA_10 PF12846.2 ESS66671.1 - 0.087 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain Acyl-CoA_dh_1 PF00441.19 ESS66672.1 - 1.4e-28 99.8 1.6 2.8e-27 95.6 0.3 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESS66672.1 - 3.2e-24 85.6 0.0 6.8e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESS66672.1 - 2e-18 65.6 0.1 4.1e-18 64.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESS66672.1 - 6.5e-10 39.3 0.1 1.3e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 ESS66672.1 - 0.097 12.0 0.1 0.72 9.1 0.0 2.0 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Hexokinase_1 PF00349.16 ESS66673.1 - 3.5e-63 212.6 0.2 5e-63 212.1 0.2 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 ESS66673.1 - 9.7e-58 195.2 0.0 1.4e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase CIDE-N PF02017.10 ESS66673.1 - 0.0039 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 CIDE-N domain PPR_2 PF13041.1 ESS66674.1 - 1.6e-14 53.5 1.3 3.7e-05 23.5 0.1 5.3 5 1 1 6 6 6 3 PPR repeat family PPR_3 PF13812.1 ESS66674.1 - 8.5e-10 38.1 11.8 0.57 10.5 0.0 8.0 8 0 0 8 8 8 3 Pentatricopeptide repeat domain PPR PF01535.15 ESS66674.1 - 3.1e-05 23.6 1.3 0.84 9.7 0.0 5.8 7 0 0 7 7 7 1 PPR repeat PPR_1 PF12854.2 ESS66674.1 - 0.0015 17.9 4.7 0.14 11.6 0.0 4.4 4 0 0 4 4 4 1 PPR repeat Pkinase PF00069.20 ESS66675.1 - 9.2e-22 77.4 0.0 1.5e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66675.1 - 1.4e-13 50.5 0.0 2.4e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CIDE-N PF02017.10 ESS66678.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 CIDE-N domain LRR_4 PF12799.2 ESS66679.1 - 0.073 12.7 2.0 0.1 12.2 0.4 1.9 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) ABC2_membrane_4 PF12730.2 ESS66680.1 - 0.00054 19.1 0.0 0.00094 18.4 0.0 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein TFIIB PF00382.14 ESS66680.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Transcription factor TFIIB repeat GTP_EFTU PF00009.22 ESS66681.1 - 8.2e-55 185.1 0.0 1.4e-54 184.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESS66681.1 - 1.1e-35 121.7 0.2 3.7e-35 120.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESS66681.1 - 1.2e-18 66.9 0.5 4.1e-18 65.2 0.4 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 zf-U1 PF06220.7 ESS66681.1 - 1.6e-05 24.3 0.7 3.4e-05 23.2 0.5 1.5 1 0 0 1 1 1 1 U1 zinc finger GTP_EFTU_D4 PF14578.1 ESS66681.1 - 3.9e-05 23.2 0.2 0.0002 20.9 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 ESS66681.1 - 6.9e-05 22.7 0.0 0.0011 18.8 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESS66681.1 - 0.0051 17.2 0.2 0.088 13.3 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein LCE PF14672.1 ESS66681.1 - 0.026 15.0 4.4 0.087 13.3 3.1 1.9 1 0 0 1 1 1 0 Late cornified envelope Semialdhyde_dhC PF02774.13 ESS66681.1 - 0.071 12.9 0.1 0.69 9.7 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Vps51 PF08700.6 ESS66682.1 - 2.3e-25 88.2 3.4 2.3e-25 88.2 2.3 2.6 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.1 ESS66682.1 - 1.5e-10 41.1 2.9 1.5e-10 41.1 2.0 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec5 Dor1 PF04124.7 ESS66682.1 - 3.3e-08 32.3 7.1 1e-07 30.8 4.9 1.8 1 0 0 1 1 1 1 Dor1-like family COG2 PF06148.6 ESS66682.1 - 4.2e-07 29.8 8.2 4.2e-07 29.8 4.0 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.4 ESS66682.1 - 7.5e-06 25.9 6.3 2.4e-05 24.2 4.4 1.9 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Vps53_N PF04100.7 ESS66682.1 - 3.4e-05 22.7 5.7 6.5e-05 21.8 3.9 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF2450 PF10475.4 ESS66682.1 - 9.6e-05 21.4 9.2 0.00018 20.5 6.3 1.3 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) NPV_P10 PF05531.7 ESS66682.1 - 0.016 15.4 0.7 0.088 13.0 0.5 2.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.4 ESS66682.1 - 0.022 14.0 2.8 0.043 13.0 1.9 1.5 1 0 0 1 1 1 0 Clusterin-associated protein-1 BLOC1_2 PF10046.4 ESS66682.1 - 0.026 14.6 3.1 0.091 12.9 1.7 2.2 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.4 ESS66682.1 - 0.029 14.2 8.6 0.063 13.1 5.9 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.7 ESS66682.1 - 0.05 13.3 1.0 0.15 11.8 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) LIF_OSM PF01291.12 ESS66682.1 - 0.055 13.4 0.3 0.19 11.6 0.2 2.0 1 0 0 1 1 1 0 LIF / OSM family Phage_GP20 PF06810.6 ESS66682.1 - 0.085 12.2 1.3 0.94 8.9 0.5 2.4 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF342 PF03961.8 ESS66682.1 - 0.14 10.5 1.4 0.22 9.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Baculo_PEP_C PF04513.7 ESS66682.1 - 0.39 10.5 3.4 0.64 9.8 0.7 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlgN PF05130.7 ESS66682.1 - 1.6 8.9 9.7 1.8 8.7 3.7 3.0 3 0 0 3 3 3 0 FlgN protein IncA PF04156.9 ESS66682.1 - 3.3 7.2 6.8 20 4.7 4.8 2.1 1 1 1 2 2 2 0 IncA protein Peptidase_M16 PF00675.15 ESS66683.1 - 3.4e-10 39.8 0.0 5.8e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESS66683.1 - 2e-07 30.8 0.0 1.2e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain RPAP2_Rtr1 PF04181.8 ESS66684.1 - 2.6e-20 72.2 1.1 5.7e-20 71.1 0.8 1.6 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF667 PF05018.8 ESS66685.1 - 7.9e-31 106.7 0.0 1.1e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) PH_4 PF15404.1 ESS66685.1 - 0.024 14.1 4.5 0.029 13.8 3.1 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain FimP PF09766.4 ESS66685.1 - 0.036 13.1 14.1 0.036 13.1 9.7 1.2 1 0 0 1 1 1 0 Fms-interacting protein DUF4140 PF13600.1 ESS66685.1 - 0.053 13.9 9.1 0.096 13.1 6.3 1.7 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) R3H-assoc PF13902.1 ESS66685.1 - 0.092 12.7 4.6 0.14 12.1 3.2 1.5 1 0 0 1 1 1 0 R3H-associated N-terminal domain PAT1 PF09770.4 ESS66685.1 - 0.13 10.5 33.4 0.13 10.4 23.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AUX_IAA PF02309.11 ESS66685.1 - 0.23 11.1 6.6 0.26 11.0 4.6 1.1 1 0 0 1 1 1 0 AUX/IAA family eIF-3_zeta PF05091.7 ESS66685.1 - 0.36 9.3 11.2 0.33 9.5 7.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hid1 PF12722.2 ESS66685.1 - 0.74 7.4 9.9 0.76 7.3 6.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CPSF100_C PF13299.1 ESS66685.1 - 0.91 9.6 7.8 1 9.5 5.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Band_3_cyto PF07565.8 ESS66685.1 - 0.98 8.8 10.2 1.1 8.6 7.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Baculo_PP31 PF05311.6 ESS66685.1 - 0.98 8.6 8.4 0.98 8.6 5.8 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) zf-DHHC PF01529.15 ESS66685.1 - 1.1 8.6 3.7 1.1 8.6 2.5 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Serinc PF03348.10 ESS66685.1 - 2.4 6.7 8.8 2.5 6.6 6.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF912 PF06024.7 ESS66685.1 - 2.5 8.1 5.6 3.9 7.5 3.9 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Neur_chan_memb PF02932.11 ESS66685.1 - 3.3 7.5 5.6 3.3 7.5 3.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Gti1_Pac2 PF09729.4 ESS66685.1 - 3.3 7.5 7.2 3.8 7.3 5.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Pex16 PF08610.5 ESS66685.1 - 3.5 6.5 10.8 3.9 6.3 7.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) RR_TM4-6 PF06459.7 ESS66685.1 - 3.7 7.3 11.7 4.2 7.1 8.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Folate_carrier PF01770.13 ESS66685.1 - 6 5.2 6.7 6.8 5.0 4.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier Presenilin PF01080.12 ESS66685.1 - 6.3 5.5 6.5 6.3 5.5 4.5 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.12 ESS66685.1 - 7.1 6.3 11.9 8.2 6.1 8.2 1.1 1 0 0 1 1 1 0 DDHD domain FAM176 PF14851.1 ESS66685.1 - 8 6.1 8.3 10 5.7 5.8 1.2 1 0 0 1 1 1 0 FAM176 family BRF1 PF07741.8 ESS66685.1 - 8.1 6.7 13.5 12 6.2 9.4 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain UCH PF00443.24 ESS66686.1 - 1.7e-49 168.3 0.0 2.4e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS66686.1 - 2e-23 83.2 0.0 3.6e-23 82.4 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Piwi PF02171.12 ESS66687.1 - 3.6e-13 49.1 0.0 7.2e-13 48.1 0.0 1.5 1 1 0 1 1 1 1 Piwi domain NAD_binding_8 PF13450.1 ESS66688.1 - 2.5e-06 27.4 0.0 1.1e-05 25.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESS66688.1 - 4.1e-05 23.5 0.0 0.00051 19.9 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS66688.1 - 0.00017 21.8 0.0 0.1 13.0 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESS66688.1 - 0.00051 20.1 0.0 0.051 13.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESS66688.1 - 0.0029 17.4 0.0 0.0069 16.1 0.0 1.6 1 1 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.12 ESS66688.1 - 0.017 14.2 0.0 0.072 12.1 0.0 1.9 2 0 0 2 2 2 0 Thi4 family DAO PF01266.19 ESS66688.1 - 0.044 12.6 0.0 0.21 10.4 0.0 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase DUF1215 PF06744.7 ESS66688.1 - 0.16 11.6 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1215) Kua-UEV1_localn PF10520.4 ESS66690.1 - 7e-71 237.5 2.7 1e-70 236.9 1.9 1.2 1 0 0 1 1 1 1 Kua-ubiquitin conjugating enzyme hybrid localisation domain PetN PF03742.9 ESS66690.1 - 0.064 12.8 0.3 0.14 11.7 0.2 1.6 1 0 0 1 1 1 0 PetN ubiquitin PF00240.18 ESS66691.1 - 5.2e-06 25.7 0.0 1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family zf-B_box PF00643.19 ESS66691.1 - 0.00031 20.5 4.0 0.00031 20.5 2.8 6.3 6 2 0 6 6 6 1 B-box zinc finger Rad60-SLD PF11976.3 ESS66691.1 - 0.087 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4088 PF13317.1 ESS66692.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Vps35 PF03635.12 ESS66693.1 - 2e-254 846.3 5.9 2.4e-254 846.1 4.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Reo_sigmaC PF04582.7 ESS66694.1 - 0.00055 19.2 1.1 0.00055 19.2 0.8 2.1 2 0 0 2 2 2 1 Reovirus sigma C capsid protein COMP PF11598.3 ESS66694.1 - 0.037 14.0 0.1 0.037 14.0 0.1 2.7 2 1 1 3 3 3 0 Cartilage oligomeric matrix protein Surfac_D-trimer PF09006.6 ESS66694.1 - 0.34 10.6 4.6 0.85 9.3 0.0 3.3 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation LRR_9 PF14580.1 ESS66695.1 - 1.3e-10 41.0 0.1 3.4e-10 39.7 0.1 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 ESS66695.1 - 4.5e-08 32.5 11.1 5.3e-06 25.9 2.5 2.8 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS66695.1 - 2.4e-05 24.0 1.1 6.9e-05 22.5 0.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_7 PF13504.1 ESS66695.1 - 0.0055 16.6 6.9 8.2 7.1 0.1 4.7 4 0 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 ESS66695.1 - 0.34 11.0 10.1 2.1 8.6 0.2 4.2 4 1 1 5 5 5 0 Leucine Rich Repeat CTDII PF01556.13 ESS66696.1 - 5.9e-22 77.3 0.1 3.5e-17 62.0 0.0 2.6 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESS66696.1 - 0.0002 21.3 6.7 0.00045 20.2 4.6 1.6 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 ESS66696.1 - 0.13 11.9 1.3 0.23 11.1 0.9 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family PQQ_3 PF13570.1 ESS66698.1 - 0.021 15.0 3.8 0.63 10.3 0.3 3.6 3 0 0 3 3 3 0 PQQ-like domain Phage_tail_T PF06223.7 ESS66699.1 - 0.051 13.9 0.0 1 9.8 0.0 2.3 2 0 0 2 2 2 0 Minor tail protein T Biotin_lipoyl PF00364.17 ESS66700.1 - 3.2e-15 55.5 0.0 6.2e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF1180 PF06679.7 ESS66700.1 - 3.3 7.5 8.1 1.1 9.0 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) La PF05383.12 ESS66701.1 - 4.6e-20 71.1 0.0 7.6e-20 70.4 0.0 1.3 1 0 0 1 1 1 1 La domain RRM_1 PF00076.17 ESS66701.1 - 2.1e-07 30.4 0.0 1.2e-06 28.0 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66701.1 - 2.3e-07 30.6 0.0 4e-06 26.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS66701.1 - 0.00063 19.5 0.0 0.12 12.2 0.0 2.8 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESS66701.1 - 0.00077 19.2 1.6 0.015 15.1 0.1 2.8 2 1 0 2 2 2 1 RNA binding motif TPR_16 PF13432.1 ESS66702.1 - 9.8e-16 57.9 16.6 3.3e-08 33.9 2.5 5.9 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66702.1 - 2.3e-14 53.4 4.6 2.3e-06 27.8 0.1 5.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS66702.1 - 5.7e-14 51.5 20.1 5.6e-05 22.7 0.0 5.9 4 2 2 6 6 6 4 TPR repeat TPR_2 PF07719.12 ESS66702.1 - 1.1e-10 40.5 17.6 0.65 10.0 0.1 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66702.1 - 1.4e-09 37.6 20.0 0.14 12.8 0.2 8.5 5 3 4 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66702.1 - 1.6e-08 34.3 16.0 0.00046 20.0 0.4 5.9 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66702.1 - 8.7e-08 31.4 12.1 0.71 9.5 0.1 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS66702.1 - 0.00017 21.1 10.3 5 7.1 0.0 6.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS66702.1 - 0.00017 21.5 1.3 0.6 10.4 0.0 4.8 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS66702.1 - 0.0012 18.5 10.7 6.8 6.7 0.0 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS66702.1 - 0.019 15.4 8.1 18 6.0 0.1 5.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.4 ESS66702.1 - 0.036 13.9 2.0 0.2 11.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS66702.1 - 0.3 11.0 10.2 6.3 6.8 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat GldM_N PF12081.3 ESS66703.1 - 0.52 9.8 11.0 0.027 14.0 1.8 2.4 2 0 0 2 2 2 0 GldM N-terminal domain DUF3450 PF11932.3 ESS66703.1 - 9.1 5.4 31.0 0.92 8.7 6.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) DUF1192 PF06698.6 ESS66703.1 - 9.3 6.1 11.0 3.1 7.6 1.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) Vps5 PF09325.5 ESS66704.1 - 0.015 14.5 11.5 0.011 14.9 7.0 1.5 1 1 1 2 2 2 0 Vps5 C terminal like DUF2884 PF11101.3 ESS66704.1 - 0.024 14.0 1.6 0.03 13.6 0.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) GSCFA PF08885.6 ESS66704.1 - 0.083 12.4 1.5 0.1 12.1 0.0 1.7 2 1 0 2 2 2 0 GSCFA family DUF2580 PF10824.3 ESS66704.1 - 0.15 12.4 1.9 0.5 10.7 0.3 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2580) DUF4407 PF14362.1 ESS66704.1 - 0.3 9.9 3.4 0.79 8.6 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF837 PF05769.6 ESS66704.1 - 0.51 9.8 11.1 2.8 7.4 6.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF837) ATP-synt_E PF05680.7 ESS66704.1 - 1 9.3 10.5 0.45 10.4 3.3 2.3 2 0 0 2 2 2 0 ATP synthase E chain Muted PF14942.1 ESS66704.1 - 1.7 8.4 8.5 3.9 7.3 3.9 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Seryl_tRNA_N PF02403.17 ESS66704.1 - 2.9 7.9 11.3 5.2 7.1 0.6 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CotJB PF12652.2 ESS66704.1 - 7 6.8 9.3 12 6.0 0.8 3.6 2 2 2 4 4 4 0 CotJB protein DUF16 PF01519.11 ESS66704.1 - 7.3 6.8 9.2 7.1 6.9 1.3 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF16 Actin PF00022.14 ESS66705.1 - 4.2e-42 143.9 0.0 5.5e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Actin zf-rbx1 PF12678.2 ESS66706.1 - 7e-33 112.5 12.6 7e-33 112.5 8.8 1.5 2 0 0 2 2 2 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESS66706.1 - 5.9e-17 61.2 9.2 1.1e-16 60.4 6.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 ESS66706.1 - 1.6e-05 24.5 13.3 1.6e-05 24.5 9.2 2.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 ESS66706.1 - 0.02 14.5 11.8 0.02 14.5 8.2 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) VSP PF03302.8 ESS66706.1 - 0.14 10.7 5.8 0.1 11.2 3.1 1.4 1 1 0 1 1 1 0 Giardia variant-specific surface protein zf-C3HC4_3 PF13920.1 ESS66706.1 - 0.32 10.7 20.3 0.16 11.6 7.2 3.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.1 ESS66706.1 - 1.2 9.3 11.1 80 3.4 7.7 2.4 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C3HC4_2 PF13923.1 ESS66706.1 - 2 8.5 20.0 3.7 7.6 8.8 3.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESS66706.1 - 2.9 7.6 12.0 13 5.6 0.2 3.1 2 1 0 2 2 2 0 RING-type zinc-finger adh_short PF00106.20 ESS66734.1 - 2.1e-06 27.7 0.0 6.9e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESS66734.1 - 0.0021 17.8 0.0 0.43 10.3 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESS66734.1 - 0.054 13.1 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 KR domain Arm PF00514.18 ESS66735.1 - 0.051 13.4 0.1 0.79 9.6 0.0 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF3508 PF12018.3 ESS66735.1 - 0.13 11.1 5.2 4.1 6.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3508) MAS20 PF02064.10 ESS66735.1 - 0.31 10.9 5.2 0.22 11.4 1.4 2.4 2 0 0 2 2 2 0 MAS20 protein import receptor Hydant_A_N PF05378.8 ESS66735.1 - 0.96 8.9 3.6 1.3 8.5 0.1 2.4 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase N-terminal region ALIX_LYPXL_bnd PF13949.1 ESS66735.1 - 5.9 5.7 11.0 2.7 6.8 2.7 2.6 3 0 0 3 3 3 0 ALIX V-shaped domain binding to HIV EF-hand_5 PF13202.1 ESS66736.1 - 4.8e-07 28.8 2.9 0.022 14.0 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.27 ESS66736.1 - 1.8e-06 26.8 2.1 0.046 13.0 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESS66736.1 - 3e-06 26.6 2.9 0.061 13.2 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 ESS66736.1 - 1.2e-05 25.3 1.3 0.022 14.8 0.0 3.1 2 2 0 2 2 2 2 EF-hand domain pair Dockerin_1 PF00404.13 ESS66736.1 - 0.00012 21.5 3.5 0.0065 16.1 0.0 2.5 2 0 0 2 2 2 2 Dockerin type I repeat EF-hand_8 PF13833.1 ESS66736.1 - 0.0034 16.9 3.3 0.026 14.1 0.1 2.7 3 0 0 3 3 3 1 EF-hand domain pair VCBS PF13517.1 ESS66736.1 - 0.082 13.2 0.0 14 6.1 0.0 2.4 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Exo_endo_phos PF03372.18 ESS66737.1 - 1.3e-07 31.8 0.0 1.5e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.18 ESS66738.1 - 0.0032 17.4 0.0 0.0043 17.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2628 PF10947.3 ESS66739.1 - 1.8 8.3 7.0 2.5 7.9 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) DUF1858 PF08984.6 ESS66740.1 - 0.063 12.9 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) Ribonuc_red_lgC PF02867.10 ESS66741.1 - 9.7e-211 700.9 0.0 1.2e-210 700.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 ESS66741.1 - 1.5e-23 82.3 0.0 3.1e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 ESS66741.1 - 6.5e-12 45.7 0.0 2e-11 44.1 0.0 1.9 1 0 0 1 1 1 1 ATP cone domain MCM PF00493.18 ESS66743.1 - 2.8e-131 437.2 0.1 2.1e-130 434.3 0.0 1.9 1 1 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESS66743.1 - 1.4e-12 48.2 1.1 7.1e-12 45.8 0.2 2.5 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESS66743.1 - 3.8e-07 29.4 0.0 2.7e-05 23.4 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESS66743.1 - 7.6e-06 25.7 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESS66743.1 - 0.0003 20.4 0.0 0.0057 16.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 ESS66743.1 - 0.016 15.4 0.0 0.054 13.6 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESS66743.1 - 0.024 14.1 0.1 0.074 12.5 0.1 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Syntaxin-6_N PF09177.6 ESS66743.1 - 0.043 14.2 0.6 0.15 12.4 0.4 2.0 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF3457 PF11939.3 ESS66743.1 - 0.082 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3457) AAA_2 PF07724.9 ESS66743.1 - 0.12 12.2 0.2 0.42 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) MUG113 PF13455.1 ESS66743.1 - 0.25 11.8 2.3 1.2 9.6 1.6 2.2 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 DUF1738 PF08401.6 ESS66744.1 - 5.1e-06 26.2 0.0 7.6e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1738) DUF1738 PF08401.6 ESS66745.1 - 0.15 11.7 0.0 14 5.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1738) DSPc PF00782.15 ESS66748.1 - 2.3e-16 59.6 0.1 7.5e-16 57.9 0.1 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PAP_assoc PF03828.14 ESS66749.1 - 2.5e-13 49.7 0.1 5.6e-13 48.6 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase SNF2_N PF00176.18 ESS66752.1 - 1.4e-60 204.6 0.4 2e-60 204.1 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS66752.1 - 8.9e-12 44.7 0.0 2.3e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 ESS66752.1 - 7.5e-07 29.0 5.6 2.3e-06 27.5 3.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS66752.1 - 2e-06 27.3 4.0 2e-06 27.3 2.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS66752.1 - 2.8e-06 26.8 4.1 2.8e-06 26.8 2.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS66752.1 - 9.1e-06 25.4 5.0 9.1e-06 25.4 3.5 2.3 2 0 0 2 2 2 1 Ring finger domain DEAD PF00270.24 ESS66752.1 - 1.1e-05 25.0 0.1 2.8e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-RING_5 PF14634.1 ESS66752.1 - 1.8e-05 24.3 4.4 4.5e-05 23.1 3.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.10 ESS66752.1 - 0.00076 19.3 0.1 0.0064 16.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4_4 PF15227.1 ESS66752.1 - 0.0027 17.5 5.6 0.0067 16.2 3.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-4CXXC_R1 PF10497.4 ESS66752.1 - 0.015 15.4 4.2 0.035 14.2 2.9 1.6 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_UBOX PF13445.1 ESS66752.1 - 0.026 14.2 1.2 0.091 12.5 0.9 2.0 1 0 0 1 1 1 0 RING-type zinc-finger DUF2315 PF10231.4 ESS66752.1 - 0.043 13.6 0.6 0.086 12.7 0.1 1.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2315) Prok-RING_4 PF14447.1 ESS66752.1 - 2.6 7.6 6.9 2.4 7.7 1.2 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Sas10 PF09368.5 ESS66754.1 - 1.2e-19 70.2 2.9 1.2e-19 70.2 2.0 2.7 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 ESS66754.1 - 3.4e-18 65.6 0.6 3.4e-18 65.6 0.4 2.2 2 0 0 2 2 2 1 Sas10/Utp3/C1D family SNARE_assoc PF09335.6 ESS66755.1 - 6.8e-11 42.4 2.0 6.8e-11 42.4 1.4 3.4 3 0 0 3 3 3 1 SNARE associated Golgi protein EF-hand_5 PF13202.1 ESS66755.1 - 0.00037 19.7 0.0 0.0011 18.2 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 ESS66755.1 - 0.0024 17.9 0.0 0.0062 16.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 ESS66755.1 - 0.0032 16.6 0.0 0.0082 15.3 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 ESS66755.1 - 0.0049 16.6 0.0 0.018 14.8 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain Pex24p PF06398.6 ESS66755.1 - 1.6 7.4 5.2 0.17 10.6 0.1 1.8 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin BTB_2 PF02214.17 ESS66756.1 - 1.1e-11 44.7 0.0 1.9e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Metallophos PF00149.23 ESS66757.1 - 2.7e-44 150.9 0.2 3.3e-44 150.6 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ank_4 PF13637.1 ESS66758.1 - 2.7e-14 53.2 0.3 2.8e-06 27.6 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 ESS66758.1 - 3e-14 52.0 0.4 3.6e-06 26.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 ESS66758.1 - 3.3e-14 52.9 0.2 8e-14 51.7 0.1 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS66758.1 - 1.1e-13 50.8 0.4 2.8e-07 30.5 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS66758.1 - 9.8e-13 47.0 0.4 0.00011 22.0 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat DUF2803 PF10972.3 ESS66758.1 - 0.11 11.9 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2803) WD40 PF00400.27 ESS66760.1 - 1.2e-34 116.9 10.8 6.9e-08 32.0 0.2 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Pkinase PF00069.20 ESS66761.1 - 1.6e-56 191.3 0.0 7.6e-56 189.1 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66761.1 - 5e-34 117.5 0.0 7.4e-32 110.4 0.0 3.1 3 0 0 3 3 3 1 Protein tyrosine kinase HEAT PF02985.17 ESS66761.1 - 0.0031 17.4 0.2 17 5.8 0.0 4.9 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 ESS66761.1 - 0.0036 17.5 4.9 0.056 13.7 0.1 4.3 4 1 1 5 5 5 2 HEAT repeats RIO1 PF01163.17 ESS66761.1 - 0.0049 16.2 0.1 2.6 7.3 0.0 2.6 2 0 0 2 2 2 2 RIO1 family HEAT_EZ PF13513.1 ESS66761.1 - 0.27 11.7 5.9 24 5.5 0.0 4.8 4 0 0 4 4 4 0 HEAT-like repeat Dynein_heavy PF03028.10 ESS66763.1 - 2.8e-217 723.1 0.0 1.6e-216 720.6 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESS66763.1 - 4.1e-128 427.3 9.9 4.1e-128 427.3 6.9 3.5 3 0 0 3 3 2 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS66763.1 - 3.6e-87 291.6 0.7 6.2e-86 287.6 0.0 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESS66763.1 - 2.2e-60 203.9 0.1 2.7e-59 200.3 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS66763.1 - 5.7e-54 182.3 0.6 1.5e-53 180.9 0.1 2.0 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS66763.1 - 9.1e-50 169.3 0.2 9.1e-50 169.3 0.2 2.1 2 0 0 2 2 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESS66763.1 - 7.7e-36 123.5 0.0 2.2e-35 122.0 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESS66763.1 - 1.8e-12 47.1 0.2 0.0011 18.7 0.0 6.5 5 2 0 5 5 5 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 ESS66763.1 - 3.5e-08 33.5 0.2 0.0041 17.2 0.0 4.2 3 0 0 3 3 3 2 RNA helicase AAA PF00004.24 ESS66763.1 - 3.2e-07 30.6 0.2 1.1 9.4 0.0 5.4 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 ESS66763.1 - 3.2e-07 30.1 1.0 0.58 9.7 0.0 3.5 3 0 0 3 3 3 3 AAA domain AAA_18 PF13238.1 ESS66763.1 - 3e-05 24.3 2.0 0.037 14.3 0.0 4.7 5 0 0 5 5 2 1 AAA domain Mg_chelatase PF01078.16 ESS66763.1 - 5.6e-05 22.3 2.8 0.046 12.8 0.0 5.0 6 0 0 6 6 6 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESS66763.1 - 6.9e-05 22.5 3.1 0.84 9.4 0.1 3.7 3 0 0 3 3 3 1 Part of AAA domain AAA_22 PF13401.1 ESS66763.1 - 8.1e-05 22.7 8.2 0.36 10.9 0.0 5.9 7 0 0 7 7 4 1 AAA domain AAA_17 PF13207.1 ESS66763.1 - 0.00013 22.7 1.7 0.12 13.2 0.0 5.4 5 0 0 5 5 2 1 AAA domain T2SE PF00437.15 ESS66763.1 - 0.00035 19.5 2.2 0.013 14.3 0.0 3.4 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_25 PF13481.1 ESS66763.1 - 0.00072 19.0 3.5 0.25 10.7 0.0 3.8 3 0 0 3 3 3 1 AAA domain ResIII PF04851.10 ESS66763.1 - 0.0012 18.7 0.1 5.2 6.8 0.0 3.7 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESS66763.1 - 0.0032 17.4 6.2 5.2 7.0 0.0 6.0 5 2 0 6 6 6 0 AAA ATPase domain IstB_IS21 PF01695.12 ESS66763.1 - 0.0046 16.4 0.9 1.7 8.0 0.0 3.5 3 0 0 3 3 3 1 IstB-like ATP binding protein DEAD PF00270.24 ESS66763.1 - 0.007 15.8 0.0 1.3 8.4 0.0 2.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.11 ESS66763.1 - 0.0076 15.4 4.1 0.32 10.2 0.1 3.6 3 0 0 3 3 3 1 PhoH-like protein NACHT PF05729.7 ESS66763.1 - 0.013 15.2 0.2 3.8 7.1 0.0 3.9 3 0 0 3 3 3 0 NACHT domain Baculo_PEP_C PF04513.7 ESS66763.1 - 0.017 14.9 0.7 2.4 8.0 0.0 3.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_33 PF13671.1 ESS66763.1 - 0.025 14.4 5.9 1.4 8.8 0.0 4.7 5 0 0 5 5 4 0 AAA domain DUF948 PF06103.6 ESS66763.1 - 0.061 13.1 11.1 0.26 11.1 0.1 4.8 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF853 PF05872.7 ESS66763.1 - 0.066 11.5 1.9 15 3.7 0.1 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) Reo_sigmaC PF04582.7 ESS66763.1 - 0.39 9.8 1.2 2.6 7.1 0.0 2.6 3 0 0 3 3 3 0 Reovirus sigma C capsid protein SRP54 PF00448.17 ESS66763.1 - 0.82 9.0 5.1 16 4.8 0.0 3.6 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Med3 PF11593.3 ESS66763.1 - 1.3 8.2 0.9 22 4.1 0.2 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal CCDC155 PF14662.1 ESS66764.1 - 0.0017 18.0 9.4 0.0017 18.0 6.5 3.8 3 1 0 3 3 3 1 Coiled-coil region of CCDC155 bZIP_1 PF00170.16 ESS66764.1 - 0.009 15.9 1.0 0.009 15.9 0.7 5.3 5 0 0 5 5 5 2 bZIP transcription factor Shugoshin_N PF07558.6 ESS66764.1 - 1.1 9.0 7.4 3 7.6 1.1 3.5 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region DUF972 PF06156.8 ESS66764.1 - 9.5 6.6 22.3 0.74 10.1 1.6 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF972) Mod_r PF07200.8 ESS66766.1 - 7.3e-11 42.2 4.3 7.3e-11 42.2 3.0 1.6 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Laminin_I PF06008.9 ESS66766.1 - 0.0063 15.8 1.9 0.0098 15.2 1.3 1.2 1 0 0 1 1 1 1 Laminin Domain I FUSC PF04632.7 ESS66766.1 - 0.023 13.1 0.9 0.035 12.5 0.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4201 PF13870.1 ESS66766.1 - 0.14 11.6 4.7 0.98 8.8 3.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) FlaC_arch PF05377.6 ESS66766.1 - 0.33 10.8 6.7 0.92 9.4 1.2 3.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DASH_Dad1 PF08649.5 ESS66766.1 - 0.35 10.5 2.9 4.8 6.9 0.0 2.8 3 0 0 3 3 3 0 DASH complex subunit Dad1 DivIVA PF05103.8 ESS66766.1 - 0.45 10.5 3.6 0.27 11.3 0.3 2.1 2 0 0 2 2 2 0 DivIVA protein IncA PF04156.9 ESS66766.1 - 0.46 10.0 9.6 1.3 8.6 1.7 2.2 1 1 1 2 2 2 0 IncA protein Apolipoprotein PF01442.13 ESS66766.1 - 1.2 8.6 7.0 13 5.1 3.8 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain TBPIP PF07106.8 ESS66766.1 - 1.2 8.6 6.8 15 5.1 4.7 2.2 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 ESS66766.1 - 1.5 9.1 5.3 8.1 6.8 0.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Baculo_PEP_C PF04513.7 ESS66766.1 - 1.8 8.3 6.5 3.5 7.4 1.4 2.6 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rad51 PF08423.6 ESS66767.1 - 8.6e-135 447.5 0.5 1.3e-134 447.0 0.3 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 ESS66767.1 - 8.3e-14 51.4 0.0 1.3e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 ESS66767.1 - 2.5e-09 37.1 0.1 6.6e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.16 ESS66767.1 - 2.1e-08 33.5 0.2 3.5e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 ESS66767.1 - 7.6e-05 21.9 0.0 0.00015 20.9 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.1 ESS66767.1 - 0.0058 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.10 ESS66767.1 - 0.052 12.4 0.0 0.095 11.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain FLO_LFY PF01698.11 ESS66767.1 - 0.12 11.2 0.1 2.6 6.8 0.0 2.3 3 0 0 3 3 3 0 Floricaula / Leafy protein AAA_23 PF13476.1 ESS66768.1 - 1.1e-13 51.9 22.6 1.1e-13 51.9 15.7 7.0 1 1 0 2 2 1 1 AAA domain SbcCD_C PF13558.1 ESS66768.1 - 1.4e-11 44.1 0.1 5.4e-11 42.2 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 ESS66768.1 - 1.1e-10 41.0 18.0 7.5e-06 25.3 0.0 2.7 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 ESS66768.1 - 2.3e-09 36.8 0.6 9.8e-05 21.5 0.0 3.3 3 1 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.1 ESS66768.1 - 3.3e-09 37.1 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_13 PF13166.1 ESS66768.1 - 8.7e-07 27.7 7.1 0.00066 18.2 5.5 6.8 5 3 2 7 7 7 4 AAA domain ABC_tran PF00005.22 ESS66768.1 - 6.1e-06 26.5 13.8 0.002 18.4 0.0 5.7 4 2 0 5 5 5 2 ABC transporter AAA_29 PF13555.1 ESS66768.1 - 0.00058 19.3 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad50_zn_hook PF04423.9 ESS66768.1 - 0.0063 15.9 0.0 0.0063 15.9 0.0 4.4 4 0 0 4 4 4 1 Rad50 zinc hook motif Tox-MPTase2 PF15638.1 ESS66768.1 - 0.0094 15.4 0.7 0.0094 15.4 0.5 2.5 2 0 0 2 2 2 1 Metallopeptidase toxin 2 AAA_19 PF13245.1 ESS66768.1 - 0.026 14.2 0.1 0.17 11.6 0.0 2.5 1 0 0 1 1 1 0 Part of AAA domain MobB PF03205.9 ESS66768.1 - 0.062 12.9 0.1 0.37 10.4 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Baculo_IE-1 PF05290.6 ESS66768.1 - 0.17 11.6 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) AAA_22 PF13401.1 ESS66768.1 - 0.27 11.3 5.0 0.46 10.6 0.0 3.9 4 0 0 4 4 3 0 AAA domain Pkinase PF00069.20 ESS66769.1 - 1.2e-59 201.5 0.0 1.4e-59 201.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66769.1 - 7.8e-39 133.3 0.0 9.5e-39 133.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS66769.1 - 2.5e-06 26.6 0.0 3.2e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESS66769.1 - 0.0061 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESS66769.1 - 0.012 15.3 0.7 0.023 14.4 0.4 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESS66769.1 - 0.013 14.5 0.2 0.025 13.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ESS66769.1 - 0.018 13.9 0.1 0.025 13.4 0.1 1.3 1 1 0 1 1 1 0 Seadornavirus VP7 Glyco_hydro_6 PF01341.12 ESS66769.1 - 0.14 11.6 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 6 RIO1 PF01163.17 ESS66769.1 - 0.15 11.3 0.0 0.36 10.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family TPR_11 PF13414.1 ESS66771.1 - 1.2e-17 63.2 7.5 6.4e-11 41.7 1.0 2.9 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 ESS66771.1 - 3.3e-15 54.7 4.0 4.3e-07 29.3 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS66771.1 - 1.9e-14 52.5 2.9 1.1e-06 27.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESS66771.1 - 1.8e-08 33.5 5.6 4.4e-05 22.9 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS66771.1 - 7.3e-08 32.8 3.9 0.0055 17.3 0.3 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66771.1 - 2.9e-06 27.1 7.3 0.0012 18.7 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS66771.1 - 5.6e-06 26.5 0.4 0.00098 19.5 0.0 3.6 2 1 2 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS66771.1 - 1.1e-05 24.8 3.1 0.061 13.1 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66771.1 - 0.00019 21.6 0.2 0.028 14.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS66771.1 - 0.0074 16.1 3.7 0.091 12.7 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-MYND PF01753.13 ESS66771.1 - 0.019 14.8 10.1 0.08 12.8 7.0 2.1 1 1 0 1 1 1 0 MYND finger MIT PF04212.13 ESS66771.1 - 0.039 13.8 2.0 0.47 10.3 0.5 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESS66771.1 - 0.075 13.5 2.7 2.6 8.7 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.7 ESS66771.1 - 0.14 12.8 4.3 11 6.7 0.1 2.8 2 0 0 2 2 2 0 Sel1 repeat Carb_anhydrase PF00194.16 ESS66772.1 - 5.2e-21 74.7 0.0 1e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase SelB-wing_2 PF09106.6 ESS66772.1 - 0.01 15.7 0.0 0.26 11.2 0.0 2.7 2 0 0 2 2 2 0 Elongation factor SelB, winged helix SIT PF15330.1 ESS66772.1 - 0.082 13.0 4.4 0.83 9.8 0.0 3.3 3 1 1 4 4 4 0 SHP2-interacting transmembrane adaptor protein, SIT T2SM PF04612.7 ESS66772.1 - 0.083 12.6 0.1 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M NLBH PF05211.7 ESS66772.1 - 0.43 9.7 7.4 4 6.6 0.5 2.3 1 1 1 2 2 2 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) Prenyltrans PF00432.16 ESS66774.1 - 2.5e-17 62.1 8.0 5.6e-07 29.0 0.5 5.5 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESS66774.1 - 0.00012 22.5 0.0 1 9.8 0.0 3.3 2 1 1 3 3 3 2 Prenyltransferase-like RNB PF00773.14 ESS66778.1 - 8e-93 311.2 0.0 1.1e-92 310.8 0.0 1.2 1 0 0 1 1 1 1 RNB domain MethyltransfD12 PF02086.10 ESS66778.1 - 0.028 13.8 0.1 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Carn_acyltransf PF00755.15 ESS66779.1 - 0.0014 16.8 0.0 0.01 14.0 0.0 1.9 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase Cas_APE2256 PF09651.5 ESS66780.1 - 0.042 13.5 0.3 5.1 6.8 0.0 3.1 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_APE2256) zf-C2H2 PF00096.21 ESS66782.1 - 3.7e-06 26.9 8.3 0.016 15.5 0.0 4.3 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS66782.1 - 1.3e-05 25.2 7.3 0.032 14.5 0.0 3.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESS66782.1 - 7.2e-05 22.8 4.1 0.26 11.4 0.0 3.5 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 ESS66782.1 - 0.016 15.4 2.8 1.1 9.7 0.0 3.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.2 ESS66782.1 - 0.019 15.1 0.1 0.019 15.1 0.1 3.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 ESS66782.1 - 0.045 13.9 6.6 0.48 10.6 0.0 3.7 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Prok-RING_4 PF14447.1 ESS66782.1 - 0.09 12.3 1.0 1.7 8.2 0.0 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 DUF1059 PF06348.6 ESS66782.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1059) DUF812 PF05667.6 ESS66784.1 - 3.6e-15 55.5 17.8 5.3e-15 54.9 12.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Integrase_DNA PF02920.10 ESS66784.1 - 0.015 14.6 0.2 0.015 14.6 0.1 2.3 3 0 0 3 3 3 0 DNA binding domain of tn916 integrase DUF3166 PF11365.3 ESS66784.1 - 2.7 8.5 15.2 1.1 9.7 3.4 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3166) DUF16 PF01519.11 ESS66784.1 - 8.2 6.7 16.5 0.28 11.4 4.7 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF16 AAA PF00004.24 ESS66785.1 - 7.8e-40 136.1 0.0 2.4e-39 134.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS66785.1 - 7.9e-06 26.0 0.1 0.00014 22.0 0.1 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESS66785.1 - 9.3e-06 24.8 0.0 2.6e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Vps4_C PF09336.5 ESS66785.1 - 0.00018 21.2 0.4 0.00086 19.1 0.1 2.4 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_25 PF13481.1 ESS66785.1 - 0.00039 19.8 1.0 0.013 14.8 0.1 2.9 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 ESS66785.1 - 0.00044 19.9 0.1 0.0018 17.9 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS66785.1 - 0.00071 19.2 0.0 0.0021 17.7 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 ESS66785.1 - 0.0011 18.9 0.2 0.0061 16.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 ESS66785.1 - 0.0014 18.5 0.2 0.0056 16.5 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.1 ESS66785.1 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESS66785.1 - 0.0022 17.2 0.0 0.0042 16.2 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 ESS66785.1 - 0.0022 18.7 1.0 0.0093 16.7 0.2 2.5 2 1 1 3 3 2 1 AAA domain IstB_IS21 PF01695.12 ESS66785.1 - 0.0023 17.3 0.0 0.0056 16.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESS66785.1 - 0.0027 17.6 0.0 0.0073 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ESS66785.1 - 0.0038 16.3 0.1 1 8.4 0.0 2.6 2 1 1 3 3 2 1 KaiC AAA_24 PF13479.1 ESS66785.1 - 0.004 16.7 0.1 0.0089 15.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESS66785.1 - 0.0048 16.6 0.0 0.6 9.7 0.0 2.6 2 0 0 2 2 2 1 Archaeal ATPase TIP49 PF06068.8 ESS66785.1 - 0.0066 15.2 0.0 0.011 14.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_18 PF13238.1 ESS66785.1 - 0.0074 16.5 0.5 0.049 13.9 0.0 2.5 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.17 ESS66785.1 - 0.011 15.9 0.0 0.031 14.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 ESS66785.1 - 0.014 14.5 0.0 0.039 13.0 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.7 ESS66785.1 - 0.019 14.6 0.0 0.059 13.0 0.0 1.8 2 0 0 2 2 1 0 NACHT domain AAA_2 PF07724.9 ESS66785.1 - 0.028 14.3 0.0 0.089 12.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.1 ESS66785.1 - 0.032 14.1 0.0 0.077 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 ESS66785.1 - 0.053 12.3 0.0 0.094 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF448 PF04296.8 ESS66785.1 - 0.085 12.5 0.3 0.64 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF448) DUF815 PF05673.8 ESS66785.1 - 0.093 11.6 0.0 0.19 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.11 ESS66785.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activ_2 PF14532.1 ESS66785.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.21 ESS66785.1 - 0.13 11.7 0.0 0.59 9.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 ESS66785.1 - 0.14 11.7 0.0 0.34 10.3 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase HK97-gp10_like PF04883.7 ESS66786.1 - 0.01 16.7 0.7 0.01 16.7 0.5 1.9 1 1 1 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component DUF2462 PF09495.5 ESS66786.1 - 3.9 8.2 16.7 0.05 14.3 3.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2462) Ribosomal_S26e PF01283.14 ESS66788.1 - 1.3e-39 134.9 2.8 1.4e-39 134.8 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e BAR PF03114.13 ESS66808.1 - 0.0031 17.0 0.1 0.0043 16.6 0.1 1.1 1 0 0 1 1 1 1 BAR domain GldM_N PF12081.3 ESS66808.1 - 0.057 12.9 2.0 0.07 12.6 0.3 1.9 2 0 0 2 2 2 0 GldM N-terminal domain IFT46_B_C PF12317.3 ESS66808.1 - 0.12 11.7 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal PGK PF00162.14 ESS66809.1 - 1.4e-104 349.7 0.0 2.2e-104 349.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoglycerate kinase cNMP_binding PF00027.24 ESS66809.1 - 0.00074 19.2 0.0 0.0022 17.7 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Ifi-6-16 PF06140.8 ESS66809.1 - 0.1 12.4 2.5 0.31 10.8 1.3 2.2 2 0 0 2 2 2 0 Interferon-induced 6-16 family LRR_4 PF12799.2 ESS66810.1 - 0.005 16.4 0.2 0.025 14.2 0.0 2.2 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) NPP PF08384.5 ESS66810.1 - 0.0093 15.5 0.1 0.033 13.8 0.1 1.9 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region LRR_8 PF13855.1 ESS66810.1 - 0.036 13.8 0.3 0.084 12.6 0.2 1.7 1 0 0 1 1 1 0 Leucine rich repeat zf-CCCH_2 PF14608.1 ESS66810.1 - 0.15 12.1 2.6 0.31 11.0 1.8 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type B3_4 PF03483.12 ESS66811.1 - 1.5e-17 63.5 0.0 2.9e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 ESS66811.1 - 9.7e-15 54.1 0.0 1.1e-13 50.7 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetase B5 domain Cir_N PF10197.4 ESS66812.1 - 0.00052 19.9 6.8 0.00052 19.9 4.7 3.2 3 1 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR CENP-Q PF13094.1 ESS66812.1 - 0.012 15.5 2.3 0.012 15.5 1.6 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Vma12 PF11712.3 ESS66812.1 - 0.022 14.4 1.2 0.043 13.5 0.8 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2681 PF10883.3 ESS66812.1 - 1.7 8.8 8.3 12 6.1 2.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DivIC PF04977.10 ESS66812.1 - 4.3 6.8 12.1 2.4 7.6 1.3 2.5 2 0 0 2 2 2 0 Septum formation initiator LRR_9 PF14580.1 ESS66813.1 - 0.031 13.8 0.1 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_4 PF12799.2 ESS66813.1 - 0.11 12.1 4.8 0.16 11.6 0.5 3.1 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) RasGEF PF00617.14 ESS66814.1 - 1.5e-22 80.2 0.1 3.3e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 ESS66814.1 - 0.0014 18.7 0.2 0.0038 17.2 0.1 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif ThiF PF00899.16 ESS66815.1 - 2.8e-41 140.5 0.1 5.3e-41 139.6 0.1 1.5 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 ESS66815.1 - 1.4e-27 95.0 1.0 4.7e-27 93.4 0.3 2.1 2 0 0 2 2 2 1 MoeZ/MoeB domain Rhodanese PF00581.15 ESS66815.1 - 7.6e-07 29.4 0.0 1.9e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain DUF3782 PF12644.2 ESS66815.1 - 0.0023 17.6 0.1 0.0049 16.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3782) Shikimate_DH PF01488.15 ESS66815.1 - 0.015 15.3 0.1 0.039 14.0 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CoA_transf_3 PF02515.12 ESS66815.1 - 0.11 11.7 0.1 0.2 10.8 0.1 1.4 1 0 0 1 1 1 0 CoA-transferase family III Pox_A_type_inc PF04508.7 ESS66815.1 - 0.35 10.7 5.6 1.1 9.2 3.9 1.9 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Strumpellin PF10266.4 ESS66816.1 - 0 1581.1 0.3 0 1580.9 0.2 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin VWA_3 PF13768.1 ESS66816.1 - 0.032 13.9 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 von Willebrand factor type A domain Ribosomal_S8 PF00410.14 ESS66818.1 - 0.06 13.1 1.2 0.2 11.5 0.1 2.0 2 0 0 2 2 2 0 Ribosomal protein S8 eRF1_2 PF03464.10 ESS66819.1 - 6e-40 136.6 0.0 1.7e-39 135.2 0.0 1.8 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.10 ESS66819.1 - 2.5e-38 130.8 1.3 3.8e-38 130.2 0.2 1.8 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.10 ESS66819.1 - 4.3e-23 81.3 0.0 8e-23 80.4 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 Topoisom_I_N PF02919.10 ESS66819.1 - 0.011 15.0 0.0 0.39 9.9 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment ABC2_membrane PF01061.19 ESS66820.1 - 2.6e-07 30.0 16.6 2.6e-07 30.0 11.5 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESS66820.1 - 3.2e-05 24.2 0.0 6.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter TraC PF07820.7 ESS66821.1 - 0.013 15.6 0.9 0.033 14.3 0.6 1.6 1 0 0 1 1 1 0 TraC-like protein IncA PF04156.9 ESS66821.1 - 3.9 7.0 13.2 74 2.8 9.1 2.2 1 1 0 1 1 1 0 IncA protein BRO1 PF03097.13 ESS66823.1 - 1.4e-74 251.1 0.1 1.4e-74 251.1 0.0 2.5 2 1 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 ESS66823.1 - 9.8e-54 182.3 13.1 9.8e-54 182.3 9.1 2.4 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Stanniocalcin PF03298.8 ESS66823.1 - 0.04 12.9 1.3 0.092 11.7 0.9 1.6 1 0 0 1 1 1 0 Stanniocalcin family Ribosomal_S17e PF00833.13 ESS66823.1 - 0.32 10.7 4.9 0.48 10.1 0.0 3.3 3 0 0 3 3 3 0 Ribosomal S17 LXG PF04740.7 ESS66823.1 - 0.41 10.4 11.4 3.4 7.3 0.5 3.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily Prominin PF05478.6 ESS66823.1 - 2.1 5.7 9.0 1.1 6.6 3.4 2.4 2 0 0 2 2 2 0 Prominin WD40 PF00400.27 ESS66824.1 - 1.5e-11 43.7 8.5 0.00027 20.6 0.5 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat IF4E PF01652.13 ESS66825.1 - 3.8e-56 189.1 0.2 6.8e-56 188.3 0.2 1.4 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E Guanylate_cyc PF00211.15 ESS66826.1 - 3.1e-43 147.2 0.0 4.5e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.1 ESS66826.1 - 1.3e-05 24.7 0.1 2.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein PrgI PF12666.2 ESS66826.1 - 0.0029 17.7 0.8 0.0071 16.4 0.0 2.0 2 0 0 2 2 2 1 PrgI family protein WBP-1 PF11669.3 ESS66827.1 - 4.7 7.3 5.2 6.4 6.9 0.7 2.4 2 0 0 2 2 2 0 WW domain-binding protein 1 Carn_acyltransf PF00755.15 ESS66828.1 - 6.5e-152 506.6 0.0 1.6e-151 505.3 0.0 1.5 2 0 0 2 2 2 1 Choline/Carnitine o-acyltransferase DAGAT PF03982.8 ESS66830.1 - 1.7e-29 102.4 0.1 7.7e-29 100.3 0.0 2.1 2 0 0 2 2 2 1 Diacylglycerol acyltransferase DEADboxA PF12343.3 ESS66831.1 - 1.4 9.2 5.0 6.4 7.1 0.1 3.1 3 0 0 3 3 3 0 Cold shock protein DEAD box A DAGAT PF03982.8 ESS66832.1 - 5.8e-20 71.1 0.0 7.1e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase ASL_C PF08328.6 ESS66835.1 - 0.0094 15.7 0.1 0.031 14.1 0.1 1.8 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal cNMP_binding PF00027.24 ESS66838.1 - 1.1e-12 47.5 0.1 2.4e-05 24.0 0.0 3.8 5 0 0 5 5 5 2 Cyclic nucleotide-binding domain O-ag_pol_Wzy PF14296.1 ESS66839.1 - 0.026 13.1 2.5 0.029 12.9 1.7 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy DUF2933 PF11666.3 ESS66839.1 - 8.2 6.0 10.3 27 4.3 7.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2933) PCI PF01399.22 ESS66840.1 - 8.4e-20 71.0 0.1 1.7e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 PCI domain Rpn3_C PF08375.6 ESS66840.1 - 1.7e-19 69.9 0.5 3.1e-19 69.1 0.4 1.5 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal HTH_27 PF13463.1 ESS66840.1 - 0.034 14.4 0.0 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain CBF PF03914.12 ESS66841.1 - 6e-35 120.1 2.6 9.5e-35 119.4 0.6 2.2 2 0 0 2 2 2 1 CBF/Mak21 family DUF2773 PF10971.3 ESS66841.1 - 0.022 14.7 0.0 0.076 12.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2773) PGA2 PF07543.7 ESS66841.1 - 4.2 7.1 8.9 14 5.4 6.1 1.9 1 0 0 1 1 1 0 Protein trafficking PGA2 AAA_4 PF04326.9 ESS66842.1 - 4.8e-06 26.7 0.0 1.3e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 Divergent AAA domain Choline_kinase PF01633.15 ESS66843.1 - 2e-23 83.0 0.4 4.5e-23 81.9 0.3 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESS66843.1 - 3.8e-10 39.8 0.1 1.4e-09 38.0 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESS66843.1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Vps16_N PF04841.8 ESS66844.1 - 3.4e-25 88.4 0.0 3.3e-18 65.4 0.0 2.5 2 1 0 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.7 ESS66844.1 - 1.4e-24 86.6 0.0 7.5e-18 64.5 0.0 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region IQ PF00612.22 ESS66846.1 - 0.019 14.5 6.0 1.5 8.6 0.1 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif Ribosomal_L10 PF00466.15 ESS66847.1 - 1.7e-24 85.6 0.2 3e-24 84.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 ESS66847.1 - 8.4e-15 54.9 9.2 2e-14 53.7 6.3 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein LicD PF04991.8 ESS66848.1 - 8.4e-07 29.2 0.1 3.4e-05 24.0 0.1 2.2 2 0 0 2 2 2 2 LicD family Mo25 PF08569.6 ESS66851.1 - 0.022 13.8 0.4 0.034 13.1 0.3 1.2 1 0 0 1 1 1 0 Mo25-like Cupin_8 PF13621.1 ESS66852.1 - 2.4e-20 73.1 0.1 6.9e-20 71.6 0.0 1.8 2 0 0 2 2 2 1 Cupin-like domain JmjC PF02373.17 ESS66852.1 - 7e-11 42.3 0.1 1.3e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 ESS66852.1 - 7.2e-05 22.1 0.0 0.00015 21.1 0.0 1.6 1 1 0 1 1 1 1 Cupin superfamily protein F-box-like PF12937.2 ESS66852.1 - 0.00025 20.6 1.9 0.00061 19.4 1.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESS66852.1 - 0.00061 19.3 1.6 0.00061 19.3 1.1 2.2 1 1 1 2 2 2 1 F-box domain Cupin_2 PF07883.6 ESS66852.1 - 0.034 13.6 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 Cupin domain tRNA-synt_1d PF00750.14 ESS66853.1 - 1.7e-86 290.2 0.0 3.2e-50 170.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.10 ESS66853.1 - 1.1e-24 86.6 0.9 3.5e-23 81.8 0.1 2.9 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 ESS66853.1 - 5.4e-13 49.2 0.0 2.4e-12 47.2 0.0 2.2 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain zf-CCCH PF00642.19 ESS66854.1 - 0.00043 19.8 7.3 0.00073 19.1 5.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Helicase_C PF00271.26 ESS66854.1 - 0.0011 18.7 0.1 0.014 15.2 0.1 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain zf-CCCH_2 PF14608.1 ESS66854.1 - 0.014 15.3 5.3 0.024 14.6 3.7 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type LRR_6 PF13516.1 ESS66856.1 - 7e-14 50.2 19.2 0.11 12.6 0.1 9.9 10 0 0 10 10 10 5 Leucine Rich repeat LRR_1 PF00560.28 ESS66856.1 - 9.3e-09 34.1 0.7 20 5.7 0.0 8.0 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.2 ESS66856.1 - 4.5e-08 32.5 6.0 0.024 14.2 0.3 5.5 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESS66856.1 - 0.0031 17.4 7.7 78 4.1 0.1 7.0 6 0 0 6 6 6 0 Leucine rich repeat LRR_8 PF13855.1 ESS66856.1 - 0.0045 16.6 5.3 2.9 7.6 1.2 4.9 3 3 1 4 4 4 2 Leucine rich repeat UCH PF00443.24 ESS66858.1 - 2.7e-54 184.0 0.0 5.1e-54 183.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS66858.1 - 4.3e-22 78.8 0.0 6.5e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Tox-REase-2 PF15646.1 ESS66858.1 - 0.0087 15.9 0.1 0.026 14.4 0.0 1.7 1 1 0 1 1 1 1 Restriction endonuclease fold toxin 2 CRC_subunit PF08624.5 ESS66858.1 - 0.14 12.1 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Chromatin remodelling complex Rsc7/Swp82 subunit DivIVA PF05103.8 ESS66858.1 - 0.42 10.6 0.0 0.42 10.6 0.0 2.2 2 0 0 2 2 2 0 DivIVA protein DZR PF12773.2 ESS66858.1 - 1.1 9.1 5.1 13 5.6 0.6 2.4 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 ESS66858.1 - 4.8 7.0 7.5 14 5.5 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbons OrfB_Zn_ribbon PF07282.6 ESS66858.1 - 6 6.6 7.3 4.9 6.8 0.1 3.1 4 0 0 4 4 4 0 Putative transposase DNA-binding domain Phage_integrase PF00589.17 ESS66859.1 - 0.078 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Phage integrase family Cation_efflux PF01545.16 ESS66861.1 - 7.4e-52 176.1 12.5 7.4e-52 176.1 8.6 1.9 2 1 0 2 2 2 1 Cation efflux family Cpn60_TCP1 PF00118.19 ESS66862.1 - 1.3e-137 459.4 7.2 1.4e-137 459.2 5.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.27 ESS66863.1 - 7.8e-25 85.8 16.0 1.7e-07 30.8 0.0 6.1 7 0 0 7 7 7 5 WD domain, G-beta repeat PD40 PF07676.7 ESS66863.1 - 0.11 12.2 0.0 16 5.2 0.0 2.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat RRM_5 PF13893.1 ESS66875.1 - 1.1e-10 41.2 0.1 7.2e-06 25.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66875.1 - 0.0068 16.3 0.1 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS66875.1 - 0.012 15.2 0.0 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS66877.1 - 3.6e-22 78.1 0.0 7.4e-06 25.8 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS66877.1 - 6.4e-18 64.3 0.0 1.2e-08 34.6 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS66877.1 - 7.8e-17 60.6 0.0 0.00015 21.3 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RasGAP PF00616.14 ESS66879.1 - 1.1e-15 57.7 0.0 1.8e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.1 ESS66879.1 - 0.072 12.9 0.0 0.34 10.8 0.0 2.1 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain tRNA-synt_2d PF01409.15 ESS66880.1 - 5.9e-81 271.2 0.2 9e-81 270.6 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 ESS66880.1 - 4.4e-06 25.7 2.5 6.6e-05 21.8 0.1 2.8 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 ESS66880.1 - 0.00034 20.2 1.3 0.00071 19.2 0.4 1.8 1 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) MarR PF01047.17 ESS66880.1 - 0.0014 18.3 0.0 0.27 10.9 0.0 2.6 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.2 ESS66880.1 - 0.0051 16.4 0.0 2.2 8.0 0.0 3.0 3 0 0 3 3 3 1 MarR family TrmB PF01978.14 ESS66880.1 - 0.035 13.7 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.1 ESS66880.1 - 0.045 13.7 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Winged helix DNA-binding domain RPA_C PF08784.6 ESS66880.1 - 0.073 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Replication protein A C terminal HTH_15 PF12324.3 ESS66880.1 - 0.097 12.3 0.1 0.92 9.2 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase CTP_transf_2 PF01467.21 ESS66881.1 - 7.4e-32 110.5 0.1 2.3e-16 60.2 0.1 2.6 2 1 0 2 2 2 2 Cytidylyltransferase FAD_syn PF06574.7 ESS66881.1 - 9.1e-05 22.1 0.9 0.44 10.1 0.0 3.6 2 1 0 2 2 2 2 FAD synthetase DUF2294 PF10057.4 ESS66881.1 - 0.017 14.7 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Abhydrolase_6 PF12697.2 ESS66882.1 - 1.3e-27 97.1 0.4 1.8e-27 96.7 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS66882.1 - 4.4e-10 39.4 0.1 2.1e-09 37.3 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS66882.1 - 7.1e-09 35.5 0.0 2.1e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 ESS66882.1 - 7.3e-06 25.7 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Chlorophyllase2 PF12740.2 ESS66882.1 - 5.5e-05 22.1 0.1 0.00028 19.8 0.1 2.0 1 1 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.16 ESS66882.1 - 0.00053 19.2 0.0 0.00085 18.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.20 ESS66882.1 - 0.0011 18.5 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_9 PF10081.4 ESS66882.1 - 0.0022 16.7 0.0 0.0033 16.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta-hydrolase family DUF2974 PF11187.3 ESS66882.1 - 0.0046 16.3 0.0 0.036 13.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Thioesterase PF00975.15 ESS66882.1 - 0.0057 16.8 0.0 0.81 9.8 0.0 2.3 2 0 0 2 2 2 1 Thioesterase domain Ser_hydrolase PF06821.8 ESS66882.1 - 0.014 14.9 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase PAF-AH_p_II PF03403.8 ESS66882.1 - 0.018 13.3 0.0 0.032 12.5 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Cutinase PF01083.17 ESS66882.1 - 0.033 13.9 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydrolase_3 PF07859.8 ESS66882.1 - 0.042 13.4 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.15 ESS66882.1 - 0.071 12.5 0.2 0.41 10.0 0.0 2.1 2 1 0 2 2 2 0 Putative esterase V_ATPase_I PF01496.14 ESS66883.1 - 5.6e-180 599.8 1.8 7.3e-180 599.4 1.2 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1615 PF07759.7 ESS66883.1 - 0.073 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) GMC_oxred_N PF00732.14 ESS66884.1 - 9.5e-05 21.6 0.0 0.016 14.3 0.0 2.3 2 0 0 2 2 2 2 GMC oxidoreductase Thi4 PF01946.12 ESS66884.1 - 0.0023 17.0 0.0 0.0041 16.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 ESS66884.1 - 0.0054 15.6 0.4 0.08 11.7 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 ESS66884.1 - 0.0057 16.7 0.1 0.05 13.6 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESS66884.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_C PF05199.8 ESS66884.1 - 0.035 14.4 0.0 0.072 13.3 0.0 1.4 1 0 0 1 1 1 0 GMC oxidoreductase NAD_binding_8 PF13450.1 ESS66884.1 - 0.054 13.5 0.0 0.17 11.9 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESS66884.1 - 0.063 13.0 0.3 0.3 10.8 0.0 2.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 ESS66884.1 - 0.14 11.1 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain CLASP_N PF12348.3 ESS66885.1 - 4.7e-24 85.0 4.0 1e-21 77.3 0.3 3.3 2 1 2 4 4 4 2 CLASP N terminal HEAT_2 PF13646.1 ESS66885.1 - 6.8e-09 35.8 7.2 0.0027 17.9 0.0 5.4 2 2 4 6 6 6 4 HEAT repeats HEAT PF02985.17 ESS66885.1 - 2e-05 24.2 4.1 0.016 15.2 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.2 ESS66885.1 - 0.00093 19.0 0.1 0.02 14.7 0.0 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 ESS66885.1 - 0.036 12.3 3.4 0.21 9.8 0.5 3.0 2 2 0 2 2 2 0 Adaptin N terminal region HEAT_EZ PF13513.1 ESS66885.1 - 0.066 13.7 3.8 1.1 9.8 0.0 4.4 4 1 0 4 4 4 0 HEAT-like repeat DUF2435 PF10363.4 ESS66886.1 - 0.083 12.8 0.2 2.3 8.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2435) SNase PF00565.12 ESS66887.1 - 2.9e-40 136.8 0.0 4.1e-12 46.3 0.0 4.4 4 0 0 4 4 4 4 Staphylococcal nuclease homologue DUF2207 PF09972.4 ESS66888.1 - 0.4 9.2 1.7 0.38 9.2 1.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) UQ_con PF00179.21 ESS66889.1 - 3e-38 130.4 0.0 4e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Peptidase_C2 PF00648.16 ESS66890.1 - 6e-05 22.1 0.0 0.00055 19.0 0.0 2.0 2 0 0 2 2 2 1 Calpain family cysteine protease RRM_1 PF00076.17 ESS66892.1 - 0.0087 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Vps23_core PF09454.5 ESS66893.1 - 8.1e-23 79.8 0.2 1.4e-22 79.0 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain UEV PF05743.8 ESS66893.1 - 0.0038 16.9 0.1 0.0065 16.1 0.0 1.4 1 0 0 1 1 1 1 UEV domain DUF1707 PF08044.6 ESS66893.1 - 0.039 13.7 1.8 0.11 12.3 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) RWD PF05773.17 ESS66893.1 - 0.059 13.2 0.1 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 RWD domain Herpeto_peptide PF14409.1 ESS66893.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Herpetosiphon DUF4566 PF15130.1 ESS66894.1 - 0.11 11.5 0.0 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4566) WD40 PF00400.27 ESS66895.1 - 1e-09 37.9 11.4 1.5e-06 27.8 0.1 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat FLgD_tudor PF13861.1 ESS66895.1 - 0.072 13.1 0.6 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 FlgD Tudor-like domain CPSF_A PF03178.10 ESS66895.1 - 0.082 11.9 0.0 3.1 6.7 0.0 2.4 2 0 0 2 2 2 0 CPSF A subunit region Cpn60_TCP1 PF00118.19 ESS66896.1 - 3.3e-144 481.1 0.6 4e-144 480.8 0.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Resolvase PF00239.16 ESS66896.1 - 0.016 15.0 0.7 0.041 13.7 0.1 2.0 2 0 0 2 2 2 0 Resolvase, N terminal domain AP_endonuc_2 PF01261.19 ESS66896.1 - 0.06 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Y_phosphatase2 PF03162.8 ESS66897.1 - 2e-21 76.0 0.0 8.3e-21 74.0 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family Pkinase PF00069.20 ESS66898.1 - 1.3e-34 119.5 0.1 4.7e-29 101.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66898.1 - 6.1e-21 74.6 0.1 1e-20 73.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS66898.1 - 0.00073 19.3 0.1 0.0027 17.5 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS66898.1 - 0.043 13.1 0.0 0.4 9.9 0.0 2.3 2 0 0 2 2 2 0 RIO1 family ADIP PF11559.3 ESS66899.1 - 0.00046 20.1 2.3 0.00046 20.1 1.6 3.6 2 1 1 3 3 3 1 Afadin- and alpha -actinin-Binding DUF4164 PF13747.1 ESS66899.1 - 0.17 12.0 18.1 0.61 10.2 3.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Fzo_mitofusin PF04799.8 ESS66899.1 - 1.3 8.3 5.6 11 5.3 0.5 3.2 3 0 0 3 3 3 0 fzo-like conserved region DUF4201 PF13870.1 ESS66899.1 - 2.6 7.4 17.4 2 7.8 1.6 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) WD40 PF00400.27 ESS66900.1 - 2.6e-13 49.2 9.1 6.4e-05 22.6 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESS66900.1 - 0.018 13.8 0.0 5.2 5.6 0.0 2.4 3 0 0 3 3 3 0 Nup133 N terminal like APG6 PF04111.7 ESS66900.1 - 0.63 9.0 10.8 1.2 8.1 7.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 ESS66900.1 - 1.4 6.6 7.2 2.5 5.8 5.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ZZ PF00569.12 ESS66901.1 - 0.024 14.1 7.9 0.065 12.7 5.5 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type HECT PF00632.20 ESS66902.1 - 4.6e-63 213.2 0.0 4.9e-63 213.1 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) CRM1_C PF08767.6 ESS66903.1 - 9.1e-58 195.6 1.6 4e-57 193.5 0.0 2.5 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.7 ESS66903.1 - 1.1e-27 96.7 2.0 4.4e-27 94.7 0.4 2.9 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.14 ESS66903.1 - 6.4e-05 22.7 0.0 0.00022 21.0 0.0 2.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain Mito_carr PF00153.22 ESS66904.1 - 9.1e-48 159.9 0.2 1.3e-16 60.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.22 ESS66905.1 - 5.9e-55 182.9 0.2 8.7e-19 67.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PPR_3 PF13812.1 ESS66908.1 - 0.037 14.2 0.6 2.7 8.5 0.0 3.7 4 0 0 4 4 4 0 Pentatricopeptide repeat domain Ribosomal_60s PF00428.14 ESS66908.1 - 0.3 11.4 2.9 0.19 12.1 0.3 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein MORN PF02493.15 ESS66910.1 - 2.9e-18 64.4 23.9 6.6e-08 31.8 1.3 6.4 6 0 0 6 6 6 5 MORN repeat Inhibitor_G39P PF11417.3 ESS66910.1 - 0.093 12.7 0.1 6.8 6.7 0.0 2.6 2 0 0 2 2 2 0 Loader and inhibitor of phage G40P DUF4366 PF14283.1 ESS66911.1 - 0.032 13.6 0.0 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) ABC2_membrane_3 PF12698.2 ESS66912.1 - 5.7e-21 74.9 31.1 1.1e-12 47.6 11.6 2.6 3 0 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.22 ESS66912.1 - 8.5e-14 52.0 0.0 4.7e-13 49.6 0.0 2.1 2 0 0 2 2 2 1 ABC transporter UPF0542 PF15086.1 ESS66912.1 - 0.72 9.6 1.9 2.4 7.9 1.3 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 ABC_tran PF00005.22 ESS66913.1 - 6.8e-15 55.5 0.0 1.2e-14 54.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.2 ESS66913.1 - 1.2e-07 31.1 19.3 1.7e-07 30.5 13.4 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.1 ESS66913.1 - 5.1e-06 26.5 0.2 2.1e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 ESS66913.1 - 0.0019 17.3 0.0 0.0034 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 ESS66913.1 - 0.0021 18.0 0.3 0.015 15.2 0.1 2.3 1 1 1 2 2 2 1 AAA domain SMC_N PF02463.14 ESS66913.1 - 0.0039 16.4 0.0 0.047 12.9 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain NACHT PF05729.7 ESS66913.1 - 0.0047 16.6 0.1 0.1 12.2 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.1 ESS66913.1 - 0.0049 16.3 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 ESS66913.1 - 0.0055 17.0 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2232 PF09991.4 ESS66913.1 - 0.013 14.4 7.6 0.022 13.7 5.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) SRP54 PF00448.17 ESS66913.1 - 0.015 14.7 0.0 0.03 13.7 0.0 1.5 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain AAA_15 PF13175.1 ESS66913.1 - 0.025 13.6 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain IspA PF04279.10 ESS66913.1 - 0.025 14.5 7.1 0.051 13.5 4.9 1.4 1 0 0 1 1 1 0 Intracellular septation protein A AAA_30 PF13604.1 ESS66913.1 - 0.03 13.8 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 ESS66913.1 - 0.037 11.3 0.1 0.047 11.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_22 PF13401.1 ESS66913.1 - 0.09 12.9 0.1 0.73 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.1 ESS66913.1 - 0.091 11.2 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESS66913.1 - 0.19 11.4 0.1 0.33 10.6 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 ESS66913.1 - 0.23 10.8 0.2 0.38 10.1 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Ank PF00023.25 ESS66914.1 - 2.7e-16 58.4 7.0 1.8e-10 40.0 0.5 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 ESS66914.1 - 9.1e-16 57.9 1.4 1.9e-15 56.9 1.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS66914.1 - 1.2e-12 47.6 4.7 5.9e-09 35.8 0.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS66914.1 - 9.4e-11 41.9 3.1 1.8e-10 41.0 1.3 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS66914.1 - 7.4e-10 38.0 2.6 2.3e-05 24.1 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat DUF641 PF04859.7 ESS66915.1 - 0.15 11.7 0.3 0.15 11.7 0.2 2.3 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) PCI_Csn8 PF10075.4 ESS66916.1 - 8e-34 116.4 0.0 1.2e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 ESS66916.1 - 3.7e-27 95.2 0.5 4.8e-27 94.8 0.4 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI PF01399.22 ESS66916.1 - 0.016 15.5 0.9 0.036 14.3 0.1 1.9 2 0 0 2 2 2 0 PCI domain IL17_R_N PF15037.1 ESS66916.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Interleukin-17 receptor extracellular region PPR_2 PF13041.1 ESS66917.1 - 4.8e-56 186.5 23.4 3e-11 43.0 0.1 11.7 7 3 5 12 12 12 10 PPR repeat family PPR_3 PF13812.1 ESS66917.1 - 1.3e-28 96.7 23.5 7.8e-06 25.7 0.0 13.7 15 1 1 16 16 15 6 Pentatricopeptide repeat domain PPR PF01535.15 ESS66917.1 - 4.4e-25 85.8 23.8 3.8e-05 23.3 0.0 12.1 13 0 0 13 13 13 6 PPR repeat PPR_1 PF12854.2 ESS66917.1 - 3.1e-19 68.1 24.2 2.4e-05 23.6 0.0 10.6 12 1 0 12 12 12 4 PPR repeat TPR_14 PF13428.1 ESS66917.1 - 2.3e-05 24.6 0.1 3.4 8.5 0.0 5.4 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS66917.1 - 0.0013 18.6 3.2 3.7 7.5 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS66917.1 - 0.002 18.4 0.1 2.2 8.6 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS66917.1 - 0.014 15.2 1.9 3.4 7.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat SPOB_a PF14689.1 ESS66917.1 - 0.03 13.8 0.4 0.21 11.1 0.0 2.7 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain Clathrin PF00637.15 ESS66917.1 - 0.038 13.5 1.7 4.7 6.8 0.1 3.8 3 2 1 4 4 4 0 Region in Clathrin and VPS RNA_pol_Rpb2_7 PF04560.15 ESS66917.1 - 0.09 13.0 0.1 26 5.1 0.0 2.9 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 7 TPR_7 PF13176.1 ESS66917.1 - 0.21 11.4 2.3 7.9 6.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS66917.1 - 2.6 8.1 10.3 1.8 8.6 0.0 3.7 5 0 0 5 5 3 0 Tetratricopeptide repeat GAS PF13851.1 ESS66918.1 - 0.049 12.8 23.3 0.03 13.5 1.2 4.6 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.7 ESS66918.1 - 5.9 6.7 8.3 2.5 7.8 0.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) ArfGap PF01412.13 ESS66919.1 - 9.3e-30 102.8 0.0 1.4e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf YadA_stalk PF05662.9 ESS66919.1 - 0.015 15.0 0.3 0.031 14.0 0.2 1.5 1 0 0 1 1 1 0 Coiled stalk of trimeric autotransporter adhesin PHTB1_N PF14727.1 ESS66920.1 - 6.7e-126 420.6 0.0 9.6e-126 420.0 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.1 ESS66920.1 - 2.6e-55 187.7 1.2 3.6e-55 187.2 0.8 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus BBS2_Mid PF14783.1 ESS66920.1 - 0.1 12.3 0.0 1.2 8.9 0.0 2.6 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region UCH PF00443.24 ESS66921.1 - 1.5e-29 102.9 0.0 2.3e-29 102.3 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS66921.1 - 4.5e-17 62.4 0.0 6.2e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CRAL_TRIO PF00650.15 ESS66922.1 - 9.4e-32 109.7 0.0 1.7e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESS66922.1 - 2.4e-06 27.5 0.1 8.6e-06 25.7 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 ESS66922.1 - 0.00041 20.2 0.0 0.00081 19.3 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 ESS66923.1 - 5.3e-43 146.2 0.0 5.8e-42 142.8 0.0 2.2 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESS66923.1 - 4.2e-06 26.7 0.0 9.5e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Pkinase PF00069.20 ESS66924.1 - 5.6e-06 25.6 0.0 2.3e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESS66924.1 - 0.00088 19.0 0.1 0.0067 16.1 0.1 2.3 3 0 0 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS66924.1 - 0.0059 16.2 0.1 0.0092 15.5 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 ESS66924.1 - 0.02 13.9 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Kinase-like PF14531.1 ESS66924.1 - 0.15 10.9 0.0 0.28 10.1 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Pep_deformylase PF01327.16 ESS66925.1 - 2.1e-22 79.1 0.0 2.9e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase WLM PF08325.5 ESS66926.1 - 1.7e-56 191.0 0.0 2.2e-36 125.5 0.0 2.7 2 1 0 2 2 2 2 WLM domain zf-RanBP PF00641.13 ESS66926.1 - 2.3e-07 29.7 26.1 0.0011 18.0 4.8 4.1 3 1 0 3 3 3 3 Zn-finger in Ran binding protein and others DUF45 PF01863.12 ESS66926.1 - 2e-06 27.7 3.1 0.00072 19.4 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function DUF45 hNIFK_binding PF12196.3 ESS66926.1 - 0.024 14.0 0.9 0.055 12.8 0.6 1.6 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Peptidase_C97 PF05903.9 ESS66928.1 - 2.9e-19 69.3 0.1 4.4e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain CPSF_A PF03178.10 ESS66929.1 - 2.6e-62 210.7 0.0 4.5e-62 209.9 0.0 1.4 1 0 0 1 1 1 1 CPSF A subunit region LicD PF04991.8 ESS66930.1 - 1.5e-11 44.7 0.0 2.8e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 LicD family mRNA_cap_enzyme PF01331.14 ESS66931.1 - 2.3e-10 40.4 0.8 8.6e-10 38.6 0.6 1.9 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain AAA_17 PF13207.1 ESS66931.1 - 1.9e-07 31.9 0.0 4.9e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain ADK PF00406.17 ESS66931.1 - 5.2e-06 26.4 0.1 3.7e-05 23.6 0.0 2.2 1 1 1 2 2 2 1 Adenylate kinase Zeta_toxin PF06414.7 ESS66931.1 - 3e-05 23.1 0.0 0.00049 19.2 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.1 ESS66931.1 - 0.00067 19.9 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain DNA_ligase_A_M PF01068.16 ESS66931.1 - 0.01 15.2 0.1 0.23 10.8 0.0 2.4 2 0 0 2 2 2 0 ATP dependent DNA ligase domain PAM2 PF07145.10 ESS66931.1 - 0.022 14.2 0.2 0.049 13.1 0.1 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region AAA_33 PF13671.1 ESS66931.1 - 0.029 14.2 0.0 0.097 12.5 0.0 1.9 1 1 1 2 2 2 0 AAA domain mRNA_cap_C PF03919.10 ESS66931.1 - 0.032 14.5 0.1 0.17 12.1 0.0 2.2 2 0 0 2 2 2 0 mRNA capping enzyme, C-terminal domain Thymidylate_kin PF02223.12 ESS66931.1 - 0.034 13.5 0.0 0.7 9.2 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_22 PF13401.1 ESS66931.1 - 0.073 13.2 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESS66931.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESS66932.1 - 3.6e-07 31.0 0.1 6.9e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESS66932.1 - 1.5e-05 24.8 0.0 2.6e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESS66932.1 - 0.0016 18.1 0.2 0.0029 17.3 0.2 1.4 1 1 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ESS66932.1 - 0.0079 16.3 0.0 0.045 13.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESS66932.1 - 0.015 15.6 0.1 0.035 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 ESS66932.1 - 0.077 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B N_NLPC_P60 PF12912.2 ESS66933.1 - 0.27 11.3 0.0 0.27 11.3 0.0 3.0 2 1 1 3 3 3 0 NLPC_P60 stabilising domain, N term DUF3357 PF11837.3 ESS66933.1 - 0.36 10.7 0.0 0.36 10.7 0.0 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF3357) SHS2_Rpb7-N PF03876.12 ESS66934.1 - 3.6e-16 59.0 0.1 6.2e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CENP-B_dimeris PF09026.5 ESS66975.1 - 0.07 13.3 6.7 5.5 7.3 4.2 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Pkinase PF00069.20 ESS66976.1 - 2.4e-28 98.9 0.0 4.6e-28 98.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66976.1 - 1.7e-23 83.0 0.0 5.2e-23 81.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS66976.1 - 0.0088 15.0 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FWWh PF14922.1 ESS66979.1 - 2.2e-24 85.8 0.5 1.7e-23 82.9 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function DUF1703 PF08011.6 ESS66979.1 - 0.12 12.0 0.3 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1703) APG6 PF04111.7 ESS66981.1 - 2.7e-24 85.8 8.2 1.4e-15 57.1 0.0 3.4 4 0 0 4 4 4 2 Autophagy protein Apg6 TBPIP PF07106.8 ESS66981.1 - 4.1 6.9 6.6 13 5.3 0.7 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) WD40 PF00400.27 ESS66982.1 - 6.6e-38 127.2 19.1 9.4e-08 31.6 1.3 9.9 9 0 0 9 9 9 7 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESS66982.1 - 4.2e-05 23.2 0.1 0.0021 17.8 0.0 3.4 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 ESS66982.1 - 0.017 13.2 9.1 2.1 6.3 0.1 3.8 2 1 1 4 4 4 0 Nucleoporin Nup120/160 AA_synth PF06684.6 ESS66983.1 - 0.0082 15.5 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Amino acid synthesis Homeobox_KN PF05920.6 ESS66983.1 - 0.052 13.2 0.0 5.6 6.7 0.0 2.8 2 0 0 2 2 2 0 Homeobox KN domain Tetraspannin PF00335.15 ESS66985.1 - 0.0089 15.3 15.0 0.22 10.7 9.2 2.4 2 0 0 2 2 2 2 Tetraspanin family ODV-E18 PF10717.4 ESS66985.1 - 9.8 5.6 12.3 6.1 6.3 0.1 2.8 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 MIF4G PF02854.14 ESS66986.1 - 0.23 10.8 1.8 9.9 5.5 0.0 2.6 2 0 0 2 2 2 0 MIF4G domain Syntaxin PF00804.20 ESS66987.1 - 0.012 15.7 0.8 0.23 11.6 0.1 2.3 2 1 0 2 2 2 0 Syntaxin DUF1048 PF06304.6 ESS66987.1 - 0.045 14.0 0.1 3.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1048) MxiH PF09392.5 ESS66987.1 - 0.055 14.0 0.6 0.33 11.5 0.0 2.5 2 1 0 2 2 2 0 Type III secretion needle MxiH like Mg-por_mtran_C PF07109.6 ESS66987.1 - 0.1 12.6 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus DUF964 PF06133.6 ESS66987.1 - 4.9 7.2 8.6 1 9.3 1.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF964) Pribosyltran_N PF13793.1 ESS66988.1 - 1.7e-25 89.0 0.0 2.4e-22 78.8 0.0 2.9 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESS66988.1 - 3.1e-23 82.4 2.5 2.3e-21 76.3 0.1 3.1 3 0 0 3 3 3 1 Phosphoribosyl synthetase-associated domain SPX PF03105.14 ESS66988.1 - 6.4e-07 29.4 8.8 0.0001 22.2 0.2 2.5 2 1 1 3 3 3 2 SPX domain Pribosyltran PF00156.22 ESS66988.1 - 0.02 14.6 0.0 6.4 6.5 0.0 2.9 3 0 0 3 3 3 0 Phosphoribosyl transferase domain Kelch_4 PF13418.1 ESS66989.1 - 1.1e-06 28.3 2.1 0.00074 19.2 0.0 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESS66989.1 - 0.00071 19.0 3.5 0.12 11.8 0.0 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.1 ESS66989.1 - 0.001 19.1 1.2 6.7 7.0 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Pkinase PF00069.20 ESS66990.1 - 6.2e-45 153.3 0.0 4.6e-44 150.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66990.1 - 1.5e-22 79.9 0.0 8.9e-18 64.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESS66990.1 - 0.014 14.2 0.0 0.026 13.3 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase PF00069.20 ESS66992.1 - 5.7e-43 146.9 0.0 1.6e-26 93.0 0.0 3.6 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS66992.1 - 8.4e-21 74.1 0.0 6e-07 28.7 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Kelch_6 PF13964.1 ESS66992.1 - 0.00069 19.6 0.0 0.03 14.5 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.20 ESS66992.1 - 0.0071 15.8 0.6 0.029 13.9 0.0 2.4 3 0 0 3 3 3 1 Kelch motif APH PF01636.18 ESS66992.1 - 0.19 11.4 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family eIF-5_eIF-2B PF01873.12 ESS66994.1 - 7.7e-24 83.7 1.0 1.3e-23 82.9 0.7 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Img2 PF05046.9 ESS66995.1 - 0.012 15.8 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) IL32 PF15225.1 ESS66997.1 - 0.045 13.7 0.1 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Interleukin 32 BNR_3 PF13859.1 ESS66998.1 - 9.4e-48 162.8 0.2 1.3e-47 162.3 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_2 PF13088.1 ESS66998.1 - 5.8e-05 22.5 1.5 0.007 15.6 0.2 2.8 1 1 2 3 3 3 2 BNR repeat-like domain BNR PF02012.15 ESS66998.1 - 0.002 17.6 6.0 0.71 9.9 0.2 3.2 2 0 0 2 2 2 2 BNR/Asp-box repeat DNA_pol_B_palm PF14792.1 ESS66999.1 - 1.7e-20 73.1 0.0 3.5e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 ESS66999.1 - 1.1e-18 66.6 0.0 4.3e-11 42.3 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 ESS66999.1 - 4e-16 58.2 0.1 1.8e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 ESS66999.1 - 8.7e-14 51.4 0.3 7.7e-12 45.2 0.1 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.1 ESS66999.1 - 6.8e-05 22.9 0.2 0.12 12.6 0.0 2.9 2 1 0 2 2 2 2 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.10 ESS66999.1 - 0.0093 15.3 0.2 4.6 6.7 0.0 3.0 2 1 0 2 2 2 2 Bacterial RNA polymerase, alpha chain C terminal domain IMS_HHH PF11798.3 ESS66999.1 - 0.01 15.8 0.0 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 IMS family HHH motif HHH_3 PF12836.2 ESS66999.1 - 0.077 12.9 0.1 5.5 7.0 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif DNA_pol_B_palm PF14792.1 ESS67000.1 - 6.8e-24 84.0 0.0 1.8e-23 82.7 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 ESS67000.1 - 4.4e-21 74.3 0.2 2e-11 43.4 0.0 2.8 2 0 0 2 2 2 2 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 ESS67000.1 - 3.3e-11 42.5 0.1 1.1e-06 28.1 0.0 2.5 2 0 0 2 2 2 2 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 ESS67000.1 - 2.4e-05 24.4 3.6 0.0083 16.2 1.0 3.8 3 1 0 3 3 3 1 Helix-hairpin-helix domain HHH_5 PF14520.1 ESS67000.1 - 0.00054 20.0 0.1 0.0021 18.1 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain Lactamase_B_2 PF12706.2 ESS67001.1 - 6.5e-40 136.7 0.1 8.7e-40 136.3 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESS67001.1 - 0.00012 21.7 0.1 0.0021 17.7 0.1 2.3 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESS67002.1 - 4.7e-11 42.5 0.0 6.8e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESS67002.1 - 9.8e-05 22.0 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.1 ESS67003.1 - 0.0013 18.1 0.0 0.0035 16.7 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Herpes_UL95 PF03038.9 ESS67005.1 - 0.42 9.4 3.5 0.53 9.0 2.4 1.1 1 0 0 1 1 1 0 UL95 family Pkinase PF00069.20 ESS67006.1 - 2.1e-63 213.9 0.0 3.6e-63 213.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67006.1 - 3.4e-49 167.2 0.0 5.3e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS67006.1 - 2.7e-07 29.8 0.1 1.3e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESS67006.1 - 0.00027 20.7 6.1 0.012 15.3 0.0 3.0 3 1 0 3 3 3 2 Phosphotransferase enzyme family DUF1181 PF06680.6 ESS67007.1 - 2.5 7.8 5.3 2 8.1 2.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1181) Dpy-30 PF05186.8 ESS67008.1 - 1.8e-08 33.7 0.1 3.6e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif YqhG PF11079.3 ESS67008.1 - 1.3 7.7 4.0 2.5 6.8 2.7 1.4 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function DUF2453 PF10507.4 ESS67009.1 - 5.7e-41 138.7 5.8 6.9e-41 138.5 1.7 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2453) AAA_5 PF07728.9 ESS67011.1 - 9e-87 287.8 0.0 6.7e-32 110.1 0.0 3.5 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS67011.1 - 7.3e-10 39.1 0.3 0.00033 20.6 0.0 4.0 3 1 1 4 4 4 2 AAA ATPase domain AAA_14 PF13173.1 ESS67011.1 - 1.6e-07 31.2 0.0 0.00037 20.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain VWA_2 PF13519.1 ESS67011.1 - 5.7e-07 29.7 0.0 1.6e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_2 PF07724.9 ESS67011.1 - 3.4e-06 27.0 0.0 0.027 14.3 0.0 3.0 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_29 PF13555.1 ESS67011.1 - 7.6e-06 25.3 0.0 0.15 11.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MCM PF00493.18 ESS67011.1 - 2.4e-05 23.2 0.6 0.022 13.5 0.0 3.2 3 0 0 3 3 3 1 MCM2/3/5 family AAA_22 PF13401.1 ESS67011.1 - 4.2e-05 23.6 0.4 0.0013 18.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 ESS67011.1 - 5e-05 23.4 0.0 0.012 15.7 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 ESS67011.1 - 0.00012 22.3 0.0 0.0016 18.7 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_17 PF13207.1 ESS67011.1 - 0.00016 22.5 0.0 0.0043 17.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS67011.1 - 0.00018 20.4 0.0 0.0023 16.8 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein Viral_helicase1 PF01443.13 ESS67011.1 - 0.00034 20.2 0.0 0.0013 18.3 0.0 2.0 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.6 ESS67011.1 - 0.00097 18.7 0.0 0.095 12.3 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ESS67011.1 - 0.0015 18.3 0.0 0.018 14.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESS67011.1 - 0.0015 18.2 0.0 0.0044 16.7 0.0 1.7 2 0 0 2 2 1 1 Archaeal ATPase AAA_18 PF13238.1 ESS67011.1 - 0.0016 18.7 0.0 0.013 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 ESS67011.1 - 0.0027 16.6 0.0 0.69 8.7 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) DUF258 PF03193.11 ESS67011.1 - 0.0035 16.5 0.0 0.25 10.5 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_28 PF13521.1 ESS67011.1 - 0.0036 17.2 0.0 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 ESS67011.1 - 0.0047 16.5 0.1 0.12 12.0 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 ESS67011.1 - 0.0073 15.9 0.1 0.034 13.7 0.0 2.3 2 0 0 2 2 1 1 NACHT domain VWA PF00092.23 ESS67011.1 - 0.0087 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Rad17 PF03215.10 ESS67011.1 - 0.013 14.2 0.0 0.022 13.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Mg_chelatase PF01078.16 ESS67011.1 - 0.016 14.3 0.2 0.016 14.3 0.1 3.7 5 1 0 5 5 3 0 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.4 ESS67011.1 - 0.029 13.0 0.0 0.31 9.6 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.17 ESS67011.1 - 0.046 13.8 0.0 0.38 10.9 0.0 2.3 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.12 ESS67011.1 - 0.055 12.8 0.1 2.6 7.4 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein PduV-EutP PF10662.4 ESS67011.1 - 0.06 12.8 0.1 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.7 ESS67011.1 - 0.07 12.1 0.1 0.63 9.0 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus ATP-synt_ab PF00006.20 ESS67011.1 - 0.1 12.0 0.0 0.42 10.0 0.0 2.0 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain G-alpha PF00503.15 ESS67011.1 - 0.14 10.8 0.0 0.25 10.0 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit Miro PF08477.8 ESS67011.1 - 0.14 12.6 0.0 3.6 8.0 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein SRP54 PF00448.17 ESS67011.1 - 0.32 10.4 0.4 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_23 PF13476.1 ESS67011.1 - 0.41 10.9 0.0 1.1 9.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Hist_deacetyl PF00850.14 ESS67013.1 - 2.3e-59 201.2 0.0 3.2e-59 200.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF3710 PF12502.3 ESS67013.1 - 0.031 13.6 0.1 0.064 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3710) Atg14 PF10186.4 ESS67014.1 - 0.054 12.4 14.0 0.13 11.2 9.7 1.6 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Reo_sigmaC PF04582.7 ESS67014.1 - 0.09 11.9 1.4 0.19 10.9 1.0 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Fib_alpha PF08702.5 ESS67014.1 - 0.094 12.8 3.9 0.3 11.1 2.7 2.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Glyco_hydro_25 PF01183.15 ESS67014.1 - 0.1 12.4 0.2 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 25 ALMT PF11744.3 ESS67014.1 - 0.59 8.7 7.6 1.2 7.7 5.2 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.11 ESS67014.1 - 4.6 5.7 4.0 7.8 4.9 2.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_S24 PF00717.18 ESS67015.1 - 5.5e-13 48.3 0.0 8.7e-13 47.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Rad60-SLD PF11976.3 ESS67017.1 - 3.6e-24 84.2 0.1 4.6e-24 83.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESS67017.1 - 6.5e-09 35.0 0.0 7.7e-09 34.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family RHH_1 PF01402.16 ESS67017.1 - 0.0021 17.8 0.0 0.0072 16.1 0.0 1.8 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family EspB PF05802.6 ESS67018.1 - 0.026 13.4 0.0 0.057 12.3 0.0 1.5 1 0 0 1 1 1 0 Enterobacterial EspB protein Neur_chan_memb PF02932.11 ESS67020.1 - 0.071 12.9 0.4 0.071 12.9 0.3 1.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4199 PF13858.1 ESS67020.1 - 0.088 12.7 0.2 0.088 12.7 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) zf-Tim10_DDP PF02953.10 ESS67021.1 - 3.5e-12 45.4 1.3 5e-12 44.9 0.9 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 ESS67021.1 - 0.0052 16.2 1.0 0.0064 15.9 0.7 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Gly-rich_Ago1 PF12764.2 ESS67032.1 - 0.5 11.0 5.9 0.88 10.2 4.1 1.4 1 0 0 1 1 1 0 Glycine-rich region of argonaut HMG_box PF00505.14 ESS67035.1 - 1.4e-40 137.4 10.8 1.4e-20 73.3 0.7 2.7 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESS67035.1 - 2.8e-25 88.4 19.6 1e-14 54.6 3.3 2.9 3 0 0 3 3 3 2 HMG-box domain DEK_C PF08766.6 ESS67035.1 - 2.6e-08 33.5 0.1 2.6e-08 33.5 0.1 2.5 2 1 0 2 2 2 1 DEK C terminal domain DUF1074 PF06382.6 ESS67035.1 - 6.1e-05 23.0 7.4 0.003 17.5 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1074) HMG_box_5 PF14887.1 ESS67035.1 - 0.033 13.9 16.2 0.078 12.7 0.4 3.0 3 1 0 3 3 3 0 HMG (high mobility group) box 5 DUF1840 PF08895.6 ESS67035.1 - 0.035 14.1 0.8 0.035 14.1 0.5 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) YABBY PF04690.8 ESS67035.1 - 0.36 11.0 2.8 0.38 10.9 0.7 1.9 2 0 0 2 2 2 0 YABBY protein Amidohydro_1 PF01979.15 ESS67037.1 - 7.4e-34 117.8 0.0 8.7e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 ESS67037.1 - 4.2e-05 23.2 0.0 0.00012 21.8 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 ESS67037.1 - 0.0093 16.0 0.0 0.049 13.6 0.0 2.2 1 1 1 2 2 2 1 Amidohydrolase A_deaminase PF00962.17 ESS67037.1 - 0.028 13.3 0.0 0.053 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenosine/AMP deaminase Amidohydro_3 PF07969.6 ESS67037.1 - 0.04 13.1 0.0 7.9 5.5 0.0 2.6 2 1 1 3 3 3 0 Amidohydrolase family TPR_14 PF13428.1 ESS67038.1 - 0.0056 17.2 0.8 4 8.3 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS67038.1 - 0.03 14.6 1.1 3.9 7.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS67038.1 - 0.11 12.3 2.6 1.9 8.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PhyH PF05721.8 ESS67039.1 - 1.1e-07 32.0 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) C1_1 PF00130.17 ESS67039.1 - 0.0013 18.3 4.1 0.0013 18.3 2.9 1.8 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 ESS67039.1 - 0.0048 16.6 3.4 0.0048 16.6 2.3 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 PHD_2 PF13831.1 ESS67039.1 - 0.4 10.0 8.9 0.051 12.9 2.8 1.9 2 0 0 2 2 2 0 PHD-finger IPPT PF01715.12 ESS67040.1 - 1.2e-40 139.1 0.0 2.5e-34 118.4 0.0 2.2 2 0 0 2 2 2 2 IPP transferase IPT PF01745.11 ESS67040.1 - 0.00038 19.7 0.0 0.029 13.5 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase AAA_16 PF13191.1 ESS67040.1 - 0.0008 19.4 0.0 0.035 14.0 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain zf-met PF12874.2 ESS67040.1 - 0.0011 19.0 0.9 0.0028 17.7 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type AAA_10 PF12846.2 ESS67040.1 - 0.0014 18.1 0.0 0.0039 16.6 0.0 1.6 1 1 0 1 1 1 1 AAA-like domain DUF2075 PF09848.4 ESS67040.1 - 0.0043 16.0 0.0 0.0063 15.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 ESS67040.1 - 0.012 15.4 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain PhoH PF02562.11 ESS67040.1 - 0.018 14.2 0.1 0.042 13.0 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.1 ESS67040.1 - 0.027 14.7 0.1 2.5 8.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain CbiA PF01656.18 ESS67040.1 - 0.032 13.6 0.0 0.057 12.8 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zot PF05707.7 ESS67040.1 - 0.04 13.3 0.0 0.085 12.3 0.0 1.5 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_17 PF13207.1 ESS67040.1 - 0.043 14.6 0.1 0.15 12.9 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 ESS67040.1 - 0.093 12.6 0.0 0.5 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 ESS67040.1 - 0.11 12.6 0.0 0.55 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain LETM1 PF07766.8 ESS67041.1 - 1.8e-38 132.1 1.1 1.8e-37 128.8 0.8 2.3 1 1 0 1 1 1 1 LETM1-like protein ABC2_membrane PF01061.19 ESS67042.1 - 5.3e-08 32.2 20.9 1.1e-07 31.3 14.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESS67042.1 - 0.00072 19.8 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter FGE-sulfatase PF03781.11 ESS67043.1 - 1.3e-17 64.0 2.8 2.6e-17 63.0 1.9 1.5 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_25 PF13649.1 ESS67043.1 - 6.7e-13 48.8 0.0 3e-12 46.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain DinB_2 PF12867.2 ESS67043.1 - 2.6e-07 31.0 0.2 5e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 DinB superfamily Methyltransf_18 PF12847.2 ESS67043.1 - 9.8e-07 29.3 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS67043.1 - 8.1e-06 25.6 0.1 3e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS67043.1 - 2.9e-05 23.6 0.0 0.15 11.6 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 ESS67043.1 - 0.00079 19.8 0.0 0.012 16.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS67043.1 - 0.017 15.5 0.0 0.084 13.3 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain DREV PF05219.7 ESS67043.1 - 0.052 12.4 0.0 8.1 5.2 0.0 3.0 2 1 0 2 2 2 0 DREV methyltransferase Kinesin PF00225.18 ESS67045.1 - 4.2e-85 285.4 0.0 4.2e-85 285.4 0.0 2.4 2 1 0 2 2 2 1 Kinesin motor domain Herpes_U30 PF04523.8 ESS67047.1 - 0.052 10.9 0.0 0.071 10.5 0.0 1.1 1 0 0 1 1 1 0 Herpes virus tegument protein U30 IncA PF04156.9 ESS67048.1 - 0.061 12.9 1.4 9 5.8 0.6 2.3 2 0 0 2 2 2 0 IncA protein GST_C_3 PF14497.1 ESS67048.1 - 0.11 13.0 0.1 0.37 11.3 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain HisKA_3 PF07730.8 ESS67048.1 - 0.11 12.8 3.0 1.9 8.9 0.1 2.9 2 0 0 2 2 2 0 Histidine kinase AAA_27 PF13514.1 ESS67048.1 - 0.22 9.1 5.9 0.18 9.4 2.4 1.7 2 0 0 2 2 2 0 AAA domain Tropomyosin_1 PF12718.2 ESS67048.1 - 1.3 8.8 7.6 0.3 10.9 0.3 2.7 2 1 1 3 3 3 0 Tropomyosin like HALZ PF02183.13 ESS67049.1 - 0.0019 17.8 0.7 0.012 15.3 0.2 2.7 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF1376 PF07120.6 ESS67049.1 - 0.014 15.5 1.0 0.24 11.5 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1376) DUF2365 PF10157.4 ESS67049.1 - 0.16 11.8 2.3 0.99 9.2 0.6 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2365) DUF3726 PF12525.3 ESS67049.1 - 0.19 11.5 2.8 0.46 10.3 0.1 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3726) V_ATPase_I PF01496.14 ESS67049.1 - 0.47 8.2 5.3 0.069 11.0 0.8 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.7 ESS67049.1 - 1.4 8.7 4.4 1.3 8.8 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) COG2 PF06148.6 ESS67049.1 - 5.6 6.8 10.7 0.97 9.3 1.1 3.3 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA_13 PF13166.1 ESS67049.1 - 6 5.1 10.8 0.042 12.3 1.4 1.8 3 0 0 3 3 3 0 AAA domain ADH_zinc_N PF00107.21 ESS67050.1 - 1.6e-15 56.8 0.2 8e-15 54.5 0.1 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESS67050.1 - 2.9e-14 52.7 1.9 1.6e-13 50.3 0.1 2.6 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 ESS67050.1 - 3.7e-11 43.9 0.2 1.3e-10 42.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase SseB PF07179.7 ESS67051.1 - 0.0001 22.1 0.1 0.04 13.7 0.0 2.4 2 0 0 2 2 2 2 SseB protein N-terminal domain cNMP_binding PF00027.24 ESS67052.1 - 1.7e-16 59.7 0.0 3.1e-09 36.5 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Cupin_2 PF07883.6 ESS67052.1 - 0.11 12.0 0.0 0.28 10.6 0.0 1.7 1 0 0 1 1 1 0 Cupin domain DUF1177 PF06675.6 ESS67053.1 - 0.0045 15.6 0.0 0.0072 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1177) Ribosomal_L4 PF00573.17 ESS67054.1 - 7.6e-39 133.0 0.1 1.3e-38 132.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 ESS67054.1 - 1e-13 50.9 5.5 1.1e-13 50.8 2.5 2.0 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ank_2 PF12796.2 ESS67055.1 - 2.7e-16 59.6 0.3 6.3e-07 29.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESS67055.1 - 1.4e-14 54.1 0.2 2.1e-07 31.2 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 ESS67055.1 - 3.2e-12 45.6 1.4 8.2e-06 25.3 0.0 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 ESS67055.1 - 5.7e-09 35.3 0.7 0.12 12.6 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 ESS67055.1 - 1.4e-08 34.6 0.1 0.0036 17.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) EH_Signature PF15611.1 ESS67056.1 - 0.0025 16.9 0.8 0.0042 16.1 0.5 1.3 1 0 0 1 1 1 1 EH_Signature domain Nipped-B_C PF12830.2 ESS67056.1 - 0.046 13.3 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus PSP1 PF04468.7 ESS67057.1 - 4.3e-14 52.2 1.2 8.3e-14 51.3 0.8 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF3686 PF12458.3 ESS67057.1 - 0.063 11.5 0.4 0.09 11.0 0.2 1.1 1 0 0 1 1 1 0 ATPase involved in DNA repair DUF3439 PF11921.3 ESS67057.1 - 4.3 7.1 8.6 15 5.4 6.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Thioredoxin_8 PF13905.1 ESS67059.1 - 7.8e-07 29.1 0.0 0.047 13.8 0.0 3.6 3 0 0 3 3 3 3 Thioredoxin-like DUF2383 PF09537.5 ESS67059.1 - 0.017 15.3 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) EI24 PF07264.6 ESS67060.1 - 8.3e-11 41.7 5.7 8.3e-11 41.7 3.9 1.4 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) Metallophos PF00149.23 ESS67061.1 - 1.1e-13 51.0 0.5 1.7e-13 50.4 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESS67061.1 - 1.7e-08 34.4 0.3 3e-08 33.6 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.5 ESS67061.1 - 0.12 10.9 0.0 3.5 6.0 0.0 2.1 2 0 0 2 2 2 0 PhoD-like phosphatase DUF572 PF04502.8 ESS67064.1 - 3.4e-17 62.6 18.9 1.3e-16 60.7 13.1 1.7 1 1 0 1 1 1 1 Family of unknown function (DUF572) Med17 PF10156.4 ESS67064.1 - 0.074 11.3 10.2 0.12 10.5 7.1 1.3 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Zn_Tnp_IS1595 PF12760.2 ESS67064.1 - 5.8 6.8 10.7 0.38 10.5 0.8 3.1 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Eapp_C PF10238.4 ESS67064.1 - 10 6.0 7.6 29 4.5 0.0 2.8 2 1 1 3 3 3 0 E2F-associated phosphoprotein Sec16_C PF12931.2 ESS67065.1 - 3.4e-19 69.6 0.0 6.4e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Wound_ind PF08186.6 ESS67065.1 - 2.9e-05 23.8 8.7 0.063 13.2 0.1 4.0 4 0 0 4 4 4 2 Wound-inducible basic protein family DUF903 PF06004.7 ESS67065.1 - 0.025 14.1 0.8 8.5 5.9 0.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF903) Dscam_C PF12355.3 ESS67065.1 - 0.092 13.0 14.1 2.1 8.6 0.5 4.4 3 0 0 3 3 3 0 Down syndrome cell adhesion molecule C terminal Lipase_3 PF01764.20 ESS67066.1 - 7.5e-31 106.6 0.0 1.2e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESS67066.1 - 0.001 18.5 0.0 0.038 13.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2974) Lipase_3 PF01764.20 ESS67067.1 - 8.4e-21 74.0 0.0 1.4e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) MIG-14_Wnt-bd PF06664.7 ESS67067.1 - 0.00035 19.5 11.0 0.00035 19.5 7.6 2.6 2 1 0 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF2974 PF11187.3 ESS67067.1 - 0.047 13.0 0.0 0.3 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Carn_acyltransf PF00755.15 ESS67069.1 - 7.1e-121 404.1 0.0 8e-121 403.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RNA_pol_Rpc34 PF05158.7 ESS67070.1 - 5.9e-96 321.4 0.0 6.5e-96 321.3 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.6 ESS67070.1 - 0.09 13.2 1.3 6.6 7.2 0.0 3.1 3 1 1 4 4 4 0 Replication protein A C terminal TrmB PF01978.14 ESS67070.1 - 0.1 12.3 0.0 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.2 ESS67070.1 - 0.11 12.2 3.0 1.4 8.6 0.1 2.5 2 0 0 2 2 2 0 MarR family Pkinase PF00069.20 ESS67071.1 - 1.4e-62 211.1 0.0 1.1e-61 208.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67071.1 - 1.6e-36 125.7 0.0 1.7e-23 82.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS67071.1 - 5e-05 22.4 0.0 0.026 13.5 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.9 ESS67071.1 - 0.0022 17.0 1.1 0.0026 16.8 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pex14_N PF04695.8 ESS67071.1 - 0.35 10.8 3.9 0.59 10.1 2.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RRM_1 PF00076.17 ESS67072.1 - 8.3e-31 105.4 0.0 2.6e-18 65.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67072.1 - 4.4e-22 77.8 0.0 1.2e-11 44.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67072.1 - 1.7e-11 43.8 0.0 6.7e-07 29.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESS67072.1 - 0.0046 16.6 0.3 0.035 13.8 0.0 2.5 2 1 0 2 2 2 1 Limkain b1 RRM_1 PF00076.17 ESS67075.1 - 2.2e-18 65.6 0.0 3.5e-09 36.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67075.1 - 7.6e-14 51.4 0.1 4e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67075.1 - 5.2e-09 35.8 0.0 3.1e-06 26.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-LYAR PF08790.6 ESS67076.1 - 4.3e-14 51.9 6.0 4.3e-14 51.9 4.1 2.1 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger Linker_histone PF00538.14 ESS67076.1 - 0.031 14.3 2.0 3.3 7.8 0.3 2.2 2 0 0 2 2 2 0 linker histone H1 and H5 family DM PF00751.13 ESS67076.1 - 0.12 11.8 1.7 0.23 11.0 1.2 1.4 1 0 0 1 1 1 0 DM DNA binding domain zf-CHY PF05495.7 ESS67076.1 - 0.64 10.2 5.0 1.3 9.2 3.5 1.4 1 0 0 1 1 1 0 CHY zinc finger MFS_1 PF07690.11 ESS67077.1 - 6.8e-10 38.1 18.8 6.8e-10 38.1 13.0 3.0 2 2 1 3 3 3 1 Major Facilitator Superfamily Asn_synthase PF00733.16 ESS67078.1 - 4.7e-31 108.2 0.0 6.1e-19 68.5 0.0 2.3 2 0 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.1 ESS67078.1 - 0.013 15.2 0.0 0.045 13.4 0.0 1.9 1 1 0 1 1 1 0 Glutamine amidotransferase domain Ank_4 PF13637.1 ESS67079.1 - 4.1e-09 36.7 0.0 9.4e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESS67079.1 - 2.4e-08 34.1 0.0 5.5e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESS67079.1 - 3.1e-07 30.0 0.0 0.00032 20.6 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 ESS67079.1 - 2e-05 24.1 0.0 0.0032 17.1 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 ESS67079.1 - 2.5e-05 24.3 0.7 0.0018 18.4 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Acetyltransf_1 PF00583.19 ESS67079.1 - 0.065 13.2 0.0 0.24 11.4 0.0 2.0 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESS67079.1 - 0.067 13.3 0.0 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain ENTH PF01417.15 ESS67081.1 - 0.1 12.4 0.1 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 ENTH domain PI3_PI4_kinase PF00454.22 ESS67082.1 - 1.3e-30 106.6 0.1 6.8e-29 100.9 0.1 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 ESS67082.1 - 1.4e-11 43.9 0.0 2.5e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ku_N PF03731.10 ESS67084.1 - 4.6e-18 65.4 0.0 1.3e-17 63.9 0.0 1.7 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.11 ESS67084.1 - 2.8e-16 59.5 0.0 4.7e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 ESS67084.1 - 0.15 12.6 0.0 0.37 11.3 0.0 1.7 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm RVT_1 PF00078.22 ESS67096.1 - 4.6e-28 98.0 0.0 6.3e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS67096.1 - 0.049 13.4 0.2 0.18 11.6 0.1 2.0 2 0 0 2 2 2 0 EBP50, C-terminal Peptidase_M8 PF01457.11 ESS67097.1 - 7.7e-95 318.1 6.1 6.4e-81 272.2 1.0 2.0 1 1 1 2 2 2 2 Leishmanolysin Astacin PF01400.19 ESS67097.1 - 0.0033 16.8 0.1 0.0068 15.8 0.1 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.19 ESS67097.1 - 0.046 13.4 0.1 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Matrixin WD40 PF00400.27 ESS67098.1 - 6.1e-22 76.6 14.9 2.1e-08 33.7 0.1 5.2 6 0 0 6 6 6 4 WD domain, G-beta repeat DivIC PF04977.10 ESS67098.1 - 0.022 14.2 0.5 0.022 14.2 0.3 3.4 4 0 0 4 4 4 0 Septum formation initiator Prp19 PF08606.6 ESS67098.1 - 0.046 13.4 5.7 0.54 10.0 0.1 3.2 3 0 0 3 3 3 0 Prp19/Pso4-like CCDC155 PF14662.1 ESS67098.1 - 0.054 13.0 23.0 0.51 9.9 1.3 3.5 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 Lge1 PF11488.3 ESS67098.1 - 0.062 13.4 2.8 0.27 11.4 0.3 2.8 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 SpoU_sub_bind PF08032.7 ESS67098.1 - 0.15 12.2 1.7 0.61 10.3 0.0 2.7 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding RICH PF05062.7 ESS67098.1 - 0.41 10.8 5.3 0.67 10.1 0.1 2.8 3 0 0 3 3 3 0 RICH domain ADIP PF11559.3 ESS67098.1 - 0.92 9.4 28.6 0.072 12.9 3.3 3.5 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.16 ESS67098.1 - 2.7 8.0 24.9 0.13 12.2 1.7 4.7 4 1 1 5 5 5 0 bZIP transcription factor OmpH PF03938.9 ESS67098.1 - 3.8 7.4 14.7 6.7 6.6 0.0 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) HALZ PF02183.13 ESS67098.1 - 4 7.2 26.9 0.18 11.5 1.2 5.1 5 0 0 5 5 5 0 Homeobox associated leucine zipper FlaC_arch PF05377.6 ESS67098.1 - 7.9 6.4 7.6 1.5 8.7 1.2 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ADK PF00406.17 ESS67099.1 - 7.2e-46 155.7 0.0 1.1e-45 155.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESS67099.1 - 2e-11 44.7 0.0 1.1e-10 42.4 0.0 2.0 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.9 ESS67099.1 - 3.3e-08 33.0 1.2 4e-08 32.7 0.1 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.1 ESS67099.1 - 3.9e-08 33.6 0.1 2.2e-07 31.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESS67099.1 - 5e-05 23.1 0.1 0.00025 20.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain Thymidylate_kin PF02223.12 ESS67099.1 - 0.0003 20.2 0.1 0.042 13.2 0.0 2.6 3 0 0 3 3 3 1 Thymidylate kinase Zeta_toxin PF06414.7 ESS67099.1 - 0.00074 18.6 0.1 0.0035 16.4 0.0 2.0 2 1 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 ESS67099.1 - 0.011 15.4 0.0 0.026 14.2 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ESS67099.1 - 0.014 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 ESS67099.1 - 0.047 13.1 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_28 PF13521.1 ESS67099.1 - 0.057 13.3 0.1 0.87 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 ESS67099.1 - 0.07 12.0 0.0 0.097 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TroA PF01297.12 ESS67099.1 - 0.15 11.3 0.0 0.3 10.2 0.0 1.4 1 0 0 1 1 1 0 Periplasmic solute binding protein family LRR_6 PF13516.1 ESS67100.1 - 7e-07 28.6 0.1 0.005 16.7 0.0 3.5 3 0 0 3 3 3 1 Leucine Rich repeat LRR_4 PF12799.2 ESS67100.1 - 2.1e-05 24.0 0.0 4.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS67100.1 - 0.0042 16.7 0.5 0.7 9.6 0.1 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_7 PF13504.1 ESS67100.1 - 0.03 14.4 0.0 1.5 9.3 0.0 2.8 2 0 0 2 2 2 0 Leucine rich repeat LRR_1 PF00560.28 ESS67100.1 - 0.052 13.5 0.7 10 6.5 0.0 3.1 3 0 0 3 3 3 0 Leucine Rich Repeat Cucumo_2B PF03263.8 ESS67100.1 - 0.053 13.8 0.4 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Cucumovirus protein 2B PPR_2 PF13041.1 ESS67101.1 - 3e-12 46.3 0.0 0.00032 20.6 0.0 4.4 4 0 0 4 4 4 3 PPR repeat family PPR PF01535.15 ESS67101.1 - 4e-06 26.4 1.3 0.42 10.7 0.0 4.2 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.1 ESS67101.1 - 4.7e-05 23.3 0.4 0.66 10.4 0.0 3.7 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESS67101.1 - 7.9 6.0 7.3 17 5.0 0.0 4.0 4 0 0 4 4 4 0 PPR repeat SelR PF01641.13 ESS67102.1 - 0.053 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 SelR domain Dicty_REP PF05086.7 ESS67102.1 - 0.24 9.1 0.9 0.27 8.9 0.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Synaptobrevin PF00957.16 ESS67104.1 - 3.7e-26 90.5 1.1 4.2e-26 90.3 0.2 1.5 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.1 ESS67104.1 - 0.0074 15.8 0.1 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain zf-RING_2 PF13639.1 ESS67106.1 - 3.9e-15 55.4 10.1 3.9e-15 55.4 7.0 3.2 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS67106.1 - 8.1e-10 38.5 11.0 8.1e-10 38.5 7.7 3.1 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESS67106.1 - 1.1e-09 38.2 3.8 1.1e-09 38.2 2.6 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESS67106.1 - 3e-08 33.1 6.7 3e-08 33.1 4.6 2.9 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS67106.1 - 3.8e-07 29.6 8.2 3.8e-07 29.6 5.7 2.9 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS67106.1 - 1.2e-06 28.3 2.3 1.2e-06 28.3 1.6 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 ESS67106.1 - 2.7e-05 23.8 6.3 2.7e-05 23.8 4.4 2.9 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESS67106.1 - 0.00061 19.4 2.7 0.00061 19.4 1.9 3.2 3 1 1 4 4 4 1 RING-type zinc-finger zf-RING_3 PF14369.1 ESS67106.1 - 0.0029 17.5 1.4 0.0029 17.5 1.0 3.7 3 0 0 3 3 3 1 zinc-finger zf-Nse PF11789.3 ESS67106.1 - 0.012 15.1 4.3 0.012 15.1 3.0 1.9 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit Baculo_RING PF05883.6 ESS67106.1 - 0.051 13.4 0.7 0.051 13.4 0.5 2.2 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain zf-RING_6 PF14835.1 ESS67106.1 - 0.32 10.8 8.5 0.52 10.1 0.7 3.4 2 1 1 3 3 3 0 zf-RING of BARD1-type protein Prok-RING_1 PF14446.1 ESS67106.1 - 1.1 9.0 10.3 2.8 7.7 0.5 3.7 3 1 1 4 4 4 0 Prokaryotic RING finger family 1 RF-1 PF00472.15 ESS67107.1 - 3.8e-12 46.0 1.4 3.8e-12 46.0 1.0 3.7 3 1 0 3 3 3 1 RF-1 domain GAS PF13851.1 ESS67107.1 - 0.0027 16.9 24.1 0.0027 16.9 16.7 3.0 3 0 0 3 3 3 1 Growth-arrest specific micro-tubule binding Macoilin PF09726.4 ESS67107.1 - 4.4 5.4 20.4 0.24 9.6 9.8 1.9 2 0 0 2 2 2 0 Transmembrane protein PhyH PF05721.8 ESS67108.1 - 0.005 16.8 0.0 0.0091 16.0 0.0 1.4 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) SMC_N PF02463.14 ESS67109.1 - 1.6e-74 249.8 0.9 2.3e-74 249.3 0.6 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESS67109.1 - 4.7e-20 71.7 0.0 1.8e-19 69.8 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 ESS67109.1 - 1.6e-13 51.2 3.2 6.4e-07 29.6 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 ESS67109.1 - 4.8e-07 29.1 0.0 1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESS67109.1 - 0.099 12.9 0.0 0.099 12.9 0.0 5.1 5 2 0 5 5 5 0 ABC transporter V-ATPase_H_N PF03224.9 ESS67110.1 - 9.3e-72 241.7 0.0 1.1e-71 241.4 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit H CENP-R PF06729.7 ESS67111.1 - 0.3 10.7 5.9 0.97 9.1 4.1 1.8 1 0 0 1 1 1 0 Kinetochore component, CENP-R PB1 PF00564.19 ESS67112.1 - 4.2e-07 29.5 0.0 1.2e-06 28.0 0.0 1.9 1 0 0 1 1 1 1 PB1 domain IFT57 PF10498.4 ESS67116.1 - 0.017 13.8 0.5 0.025 13.3 0.3 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Myosin_tail_1 PF01576.14 ESS67116.1 - 0.044 11.5 4.0 0.058 11.1 2.8 1.0 1 0 0 1 1 1 0 Myosin tail DUF4407 PF14362.1 ESS67116.1 - 0.67 8.8 8.5 1.2 7.9 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-DHHC PF01529.15 ESS67118.1 - 9.5e-35 119.5 7.8 9.5e-35 119.5 5.4 2.2 1 1 1 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.1 ESS67118.1 - 0.058 13.1 1.6 0.11 12.3 1.1 1.3 1 0 0 1 1 1 0 Transglutaminase-like superfamily Reticulon PF02453.12 ESS67118.1 - 7.3 6.1 10.6 1.1 8.8 0.8 3.5 3 1 0 3 3 3 0 Reticulon DUF971 PF06155.7 ESS67119.1 - 7.5e-17 61.5 0.0 1.7e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) DUF2442 PF10387.4 ESS67119.1 - 0.028 14.4 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) DUF393 PF04134.7 ESS67120.1 - 3.5e-07 31.3 4.7 3.4e-05 24.9 3.3 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF393 WTX PF09422.5 ESS67120.1 - 0.14 11.0 0.4 0.19 10.6 0.3 1.1 1 0 0 1 1 1 0 WTX protein E1_dh PF00676.15 ESS67121.1 - 1.3e-78 263.7 0.0 2e-78 263.1 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 ESS67121.1 - 0.0096 14.8 0.0 0.25 10.2 0.0 2.3 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase PRMT5 PF05185.11 ESS67122.1 - 4.7e-73 246.6 0.0 6.6e-73 246.1 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PBP1_TM PF14812.1 ESS67123.1 - 0.35 11.2 5.9 1.7 8.9 3.4 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2458 PF10454.4 ESS67124.1 - 0.068 13.0 11.5 0.15 11.9 8.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Ribosomal_S10 PF00338.17 ESS67124.1 - 0.095 12.5 0.6 0.25 11.2 0.4 1.7 1 0 0 1 1 1 0 Ribosomal protein S10p/S20e HMG_box PF00505.14 ESS67127.1 - 9.1e-05 22.6 2.7 0.012 15.8 0.7 3.3 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESS67127.1 - 0.00092 19.5 4.7 0.008 16.5 1.2 2.9 2 1 0 2 2 2 1 HMG-box domain Sec8_exocyst PF04048.9 ESS67128.1 - 3.4e-09 36.4 0.2 1.2e-08 34.7 0.1 2.0 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 ESS67128.1 - 9.9e-05 21.3 0.7 9.9e-05 21.3 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) PPE PF00823.14 ESS67128.1 - 0.071 12.9 2.1 0.23 11.2 1.4 1.8 1 0 0 1 1 1 0 PPE family Myc_N PF01056.13 ESS67128.1 - 0.13 11.4 3.6 0.25 10.4 2.5 1.4 1 0 0 1 1 1 0 Myc amino-terminal region DEAD PF00270.24 ESS67130.1 - 6.4e-35 120.1 0.2 5.5e-34 117.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS67130.1 - 4.6e-21 74.4 0.3 2.1e-20 72.3 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS67130.1 - 9.8e-06 25.5 0.0 2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 ESS67130.1 - 0.00023 20.3 1.2 0.00042 19.4 0.0 2.0 3 0 0 3 3 3 1 U3-containing 90S pre-ribosomal complex subunit LETM1 PF07766.8 ESS67131.1 - 2.9e-08 33.0 0.0 3.5e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 LETM1-like protein PAS_11 PF14598.1 ESS67131.1 - 0.36 10.7 2.4 0.65 9.9 0.0 2.4 3 0 0 3 3 3 0 PAS domain GST_C_3 PF14497.1 ESS67132.1 - 0.0024 18.3 0.0 0.0037 17.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESS67132.1 - 0.0053 16.6 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Activator_LAG-3 PF11498.3 ESS67135.1 - 1.8 7.2 15.1 3.2 6.4 10.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 GMC_oxred_N PF00732.14 ESS67136.1 - 2.1e-15 56.6 0.0 2.7e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 ESS67136.1 - 3.8e-09 36.9 0.0 3.3e-08 33.9 0.0 2.2 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 ESS67136.1 - 1.3e-06 27.5 0.1 0.0018 17.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 ESS67136.1 - 1.1e-05 24.5 3.2 0.00019 20.4 2.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 ESS67136.1 - 0.0023 16.4 0.2 0.027 12.9 0.0 2.5 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_2 PF07992.9 ESS67136.1 - 0.0023 17.8 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS67136.1 - 0.0026 17.7 0.2 0.0078 16.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 ESS67136.1 - 0.0037 16.2 0.1 0.01 14.8 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 ESS67136.1 - 0.01 14.9 0.1 0.26 10.2 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.1 ESS67136.1 - 0.011 15.8 0.0 0.39 10.7 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS67136.1 - 0.063 13.6 0.3 0.18 12.2 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS67136.1 - 0.076 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pkinase PF00069.20 ESS67137.1 - 1.8e-67 227.2 0.0 4.9e-67 225.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67137.1 - 1.2e-44 152.3 0.0 2.2e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS67137.1 - 2.6e-06 26.6 0.0 6.1e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 Kinase-like MIP-T3 PF10243.4 ESS67138.1 - 3.1e-122 408.7 64.9 5.5e-122 407.9 45.0 1.4 1 1 0 1 1 1 1 Microtubule-binding protein MIP-T3 peroxidase PF00141.18 ESS67139.1 - 1.2e-05 24.9 0.0 2e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 Peroxidase MerR-DNA-bind PF09278.6 ESS67139.1 - 0.026 14.8 0.0 0.062 13.7 0.0 1.7 1 1 0 1 1 1 0 MerR, DNA binding WD40 PF00400.27 ESS67140.1 - 4.3e-05 23.2 3.6 0.083 12.8 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat Phasin PF05597.6 ESS67141.1 - 0.23 11.2 3.6 0.49 10.1 0.7 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) FUSC PF04632.7 ESS67141.1 - 0.29 9.5 1.9 0.38 9.1 1.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Apolipoprotein PF01442.13 ESS67141.1 - 0.41 10.1 10.6 1.4 8.3 2.6 3.0 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain Syntaxin-6_N PF09177.6 ESS67141.1 - 0.84 10.0 3.7 7 7.1 1.1 2.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal TRP PF06011.7 ESS67143.1 - 0.00014 20.6 2.8 0.00021 20.0 2.0 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel F-box PF00646.28 ESS67143.1 - 0.0053 16.3 0.2 0.027 14.1 0.2 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 ESS67143.1 - 0.014 15.1 1.5 0.029 14.0 1.0 1.6 1 0 0 1 1 1 0 F-box-like PPR_2 PF13041.1 ESS67144.1 - 1.8e-07 30.9 0.1 4.2e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 PPR repeat family PPR_3 PF13812.1 ESS67144.1 - 1.8e-05 24.6 0.2 0.0016 18.6 0.0 3.1 2 1 0 2 2 2 1 Pentatricopeptide repeat domain PPR PF01535.15 ESS67144.1 - 4.8e-05 23.0 0.2 0.00097 18.9 0.0 2.8 3 0 0 3 3 3 1 PPR repeat EF-hand_5 PF13202.1 ESS67145.1 - 0.0016 17.6 0.3 0.064 12.6 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_1 PF00036.27 ESS67145.1 - 0.0017 17.4 0.1 0.052 12.8 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 ESS67145.1 - 0.0026 17.4 0.0 0.028 14.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain Pkinase PF00069.20 ESS67146.1 - 1.1e-47 162.4 0.0 1.6e-47 161.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67146.1 - 1.1e-18 67.2 0.0 4.5e-18 65.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESS67146.1 - 0.0054 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS67146.1 - 0.029 13.9 0.2 0.09 12.3 0.1 1.8 1 1 0 1 1 1 0 Choline/ethanolamine kinase 5_3_exonuc_N PF02739.11 ESS67147.1 - 1e-15 57.5 1.0 2.9e-13 49.5 0.7 3.0 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.15 ESS67147.1 - 1.1e-15 57.7 0.1 1.8e-15 56.9 0.1 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold GAS PF13851.1 ESS67149.1 - 0.16 11.1 13.6 1 8.5 5.3 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding BLOC1_2 PF10046.4 ESS67149.1 - 0.3 11.2 5.9 8 6.6 0.0 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 ESS67149.1 - 1.4 8.5 16.4 3.8 7.0 1.9 2.4 2 0 0 2 2 2 0 IncA protein PUF PF00806.14 ESS67150.1 - 2.8e-49 161.8 3.1 5.4e-06 25.5 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Herpes_ICP4_N PF03584.10 ESS67150.1 - 0.0022 17.5 0.0 0.0067 15.9 0.0 1.8 2 0 0 2 2 2 1 Herpesvirus ICP4-like protein N-terminal region HupH_C PF04809.8 ESS67150.1 - 0.03 14.0 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 0 HupH hydrogenase expression protein, C-terminal conserved region DUF607 PF04678.8 ESS67151.1 - 1.1e-39 136.1 0.0 1.9e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF607 Histidinol_dh PF00815.15 ESS67151.1 - 0.0068 15.0 0.0 0.0097 14.5 0.0 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase DUF2157 PF09925.4 ESS67151.1 - 0.051 13.1 0.1 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Proteasome PF00227.21 ESS67152.1 - 8.9e-65 217.5 0.0 1.3e-64 217.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESS67152.1 - 3.5e-10 38.9 0.7 2e-09 36.5 0.1 2.2 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RecA PF00154.16 ESS67152.1 - 0.0085 15.1 0.1 0.035 13.1 0.0 1.8 2 0 0 2 2 2 1 recA bacterial DNA recombination protein Pex14_N PF04695.8 ESS67154.1 - 3.2e-27 95.2 5.2 7e-27 94.1 0.0 2.9 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Macoilin PF09726.4 ESS67154.1 - 0.00016 20.1 0.9 0.00017 20.0 0.6 1.2 1 0 0 1 1 1 1 Transmembrane protein DUF812 PF05667.6 ESS67154.1 - 0.0012 17.4 4.8 0.0018 16.8 3.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) CALCOCO1 PF07888.6 ESS67154.1 - 0.0014 17.0 0.6 0.0023 16.2 0.4 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Rootletin PF15035.1 ESS67154.1 - 0.0016 18.4 1.6 0.0033 17.4 1.1 1.5 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion ATG16 PF08614.6 ESS67154.1 - 0.0032 17.3 4.6 0.0059 16.4 3.2 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) ERM PF00769.14 ESS67154.1 - 0.0045 16.5 10.0 0.0086 15.6 7.0 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF3450 PF11932.3 ESS67154.1 - 0.0069 15.6 1.5 0.011 15.0 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) OmpH PF03938.9 ESS67154.1 - 0.0071 16.3 1.3 0.015 15.2 0.9 1.6 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Myosin_tail_1 PF01576.14 ESS67154.1 - 0.0084 13.8 8.8 0.013 13.2 6.1 1.2 1 0 0 1 1 1 1 Myosin tail Snf7 PF03357.16 ESS67154.1 - 0.01 15.2 11.3 0.36 10.1 0.7 3.2 3 0 0 3 3 3 0 Snf7 KLRAQ PF10205.4 ESS67154.1 - 0.016 15.2 9.2 0.018 15.0 0.7 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein V_ATPase_I PF01496.14 ESS67154.1 - 0.025 12.4 1.6 0.036 11.9 1.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Reo_sigmaC PF04582.7 ESS67154.1 - 0.043 12.9 2.7 0.064 12.4 1.9 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.4 ESS67154.1 - 0.045 13.6 10.8 0.1 12.4 7.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2968 PF11180.3 ESS67154.1 - 0.055 12.8 7.6 0.09 12.1 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF1192 PF06698.6 ESS67154.1 - 0.091 12.5 0.5 0.091 12.5 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PEARLI-4 PF05278.7 ESS67154.1 - 0.092 12.1 4.3 0.18 11.1 3.0 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) HAUS6_N PF14661.1 ESS67154.1 - 0.097 12.0 2.8 0.16 11.3 1.9 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus ADIP PF11559.3 ESS67154.1 - 0.1 12.4 13.4 0.2 11.5 9.3 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Rabaptin PF03528.10 ESS67154.1 - 0.11 12.3 10.1 0.047 13.6 2.6 2.4 1 1 1 2 2 2 0 Rabaptin Alpha-2-MRAP_C PF06401.6 ESS67154.1 - 0.17 11.6 8.0 0.31 10.8 4.0 2.0 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain Filament PF00038.16 ESS67154.1 - 0.2 11.0 9.8 0.047 13.1 4.6 1.5 2 0 0 2 2 1 0 Intermediate filament protein Mnd1 PF03962.10 ESS67154.1 - 0.21 11.2 9.7 0.038 13.6 3.8 1.8 2 0 0 2 2 2 0 Mnd1 family Tropomyosin PF00261.15 ESS67154.1 - 0.22 10.5 12.3 0.068 12.2 3.4 2.4 1 1 1 2 2 2 0 Tropomyosin Tropomyosin_1 PF12718.2 ESS67154.1 - 0.31 10.9 18.4 0.089 12.6 9.9 2.2 2 1 0 2 2 2 0 Tropomyosin like BCAS2 PF05700.6 ESS67154.1 - 0.31 10.4 6.9 0.57 9.5 4.8 1.3 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) TBPIP PF07106.8 ESS67154.1 - 0.44 10.0 11.5 0.065 12.7 5.0 1.7 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fib_alpha PF08702.5 ESS67154.1 - 0.56 10.3 8.1 0.28 11.3 3.5 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3735 PF12537.3 ESS67154.1 - 0.91 9.6 2.6 27 4.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3735) DUF342 PF03961.8 ESS67154.1 - 0.93 7.8 8.1 0.4 9.0 3.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF342) APG6 PF04111.7 ESS67154.1 - 1 8.3 6.7 1.6 7.6 4.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Striatin PF08232.7 ESS67154.1 - 1.1 9.6 12.9 0.57 10.4 4.5 2.6 2 1 1 3 3 2 0 Striatin family IncA PF04156.9 ESS67154.1 - 1.1 8.8 12.5 2.2 7.8 8.6 1.6 1 1 0 1 1 1 0 IncA protein DivIC PF04977.10 ESS67154.1 - 1.6 8.2 11.9 0.16 11.4 0.7 2.3 1 1 1 2 2 2 0 Septum formation initiator DUF3584 PF12128.3 ESS67154.1 - 1.9 5.7 9.5 2.6 5.2 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc24 PF08286.6 ESS67154.1 - 5.2 6.7 13.0 3.6 7.3 2.4 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Flagellin_N PF00669.15 ESS67154.1 - 6.5 6.5 8.5 1.6e+02 2.0 5.9 2.3 1 1 0 1 1 1 0 Bacterial flagellin N-terminal helical region DegS PF05384.6 ESS67154.1 - 6.6 5.9 11.1 2.2 7.4 0.3 3.2 2 1 1 3 3 3 0 Sensor protein DegS Atg14 PF10186.4 ESS67154.1 - 6.9 5.5 11.3 24 3.7 8.1 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIVA PF05103.8 ESS67154.1 - 9.2 6.3 12.5 12 5.9 1.2 2.5 1 1 1 2 2 2 0 DivIVA protein Cortex-I_coil PF09304.5 ESS67154.1 - 9.2 6.3 17.3 0.2 11.6 3.0 2.6 2 1 1 3 3 2 0 Cortexillin I, coiled coil Proteasome PF00227.21 ESS67155.1 - 5.5e-57 192.1 0.0 7.1e-57 191.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESS67155.1 - 7.8e-14 50.6 0.0 2.2e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Gaa1 PF04114.9 ESS67156.1 - 1.5e-05 23.9 0.0 2.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component DUF3088 PF11287.3 ESS67156.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3088) ATP-synt PF00231.14 ESS67157.1 - 7.2e-34 117.4 2.5 8.2e-34 117.2 1.7 1.0 1 0 0 1 1 1 1 ATP synthase Adaptin_binding PF10199.4 ESS67157.1 - 0.09 13.0 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DKCLD PF08068.7 ESS67158.1 - 2.2e-27 94.7 0.0 2e-26 91.7 0.0 2.5 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 ESS67158.1 - 7.3e-23 81.3 1.9 1.9e-19 70.2 1.3 3.2 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 ESS67158.1 - 3.3e-19 68.3 0.7 6.7e-19 67.4 0.5 1.5 1 0 0 1 1 1 1 PUA domain Aa_trans PF01490.13 ESS67159.1 - 5.5e-41 140.4 25.8 6.8e-41 140.0 17.9 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4231 PF14015.1 ESS67159.1 - 0.63 10.0 5.2 0.67 9.9 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) RHSP PF07999.6 ESS67187.1 - 4.3e-84 282.6 0.2 6.7e-84 282.0 0.1 1.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS67187.1 - 0.016 15.3 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain RHSP PF07999.6 ESS67188.1 - 2.1e-12 46.4 1.3 2.9e-12 45.9 0.9 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS67189.1 - 1.6e-89 300.5 0.0 1.6e-89 300.5 0.0 1.9 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_22 PF13401.1 ESS67189.1 - 0.00064 19.8 0.3 0.86 9.7 0.0 3.0 4 0 0 4 4 4 2 AAA domain AAA PF00004.24 ESS67189.1 - 0.055 13.6 0.0 12 6.0 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BNR_3 PF13859.1 ESS67192.1 - 4.1e-66 223.1 2.0 7.9e-66 222.2 1.4 1.4 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS67192.1 - 4.1e-12 46.5 0.1 1.9e-11 44.4 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Glycos_transf_2 PF00535.21 ESS67193.1 - 2.4e-05 24.0 0.0 4.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS67193.1 - 0.0026 16.8 0.0 0.4 9.7 0.1 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESS67193.1 - 0.053 13.2 0.3 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family group 2 HAUS4 PF14735.1 ESS67193.1 - 0.2 10.9 0.0 0.29 10.4 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 RRM_1 PF00076.17 ESS67194.1 - 7.4e-21 73.5 0.0 2.8e-15 55.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67194.1 - 4.3e-18 65.0 0.1 1.1e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67194.1 - 4.4e-09 36.0 0.0 1.7e-08 34.2 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cpn60_TCP1 PF00118.19 ESS67195.1 - 1.9e-141 472.0 1.4 2.1e-141 471.8 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dynein_heavy PF03028.10 ESS67196.1 - 1.1e-231 770.8 0.0 5.9e-173 576.6 0.0 2.3 2 0 0 2 2 2 2 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 ESS67196.1 - 3.9e-119 398.6 0.8 3.9e-119 398.6 0.5 4.1 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.2 ESS67196.1 - 3.7e-117 389.8 0.3 2.9e-115 383.6 0.1 3.4 4 0 0 4 4 3 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N2 PF08393.8 ESS67196.1 - 7.1e-112 373.8 10.1 7.1e-112 373.8 7.0 4.0 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.2 ESS67196.1 - 1.4e-92 309.5 0.0 2.9e-92 308.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS67196.1 - 6.7e-83 276.9 0.3 1.3e-82 276.0 0.2 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS67196.1 - 8.7e-80 268.0 13.4 2.4e-79 266.6 9.3 1.8 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESS67196.1 - 1e-79 267.4 1.3 2.6e-79 266.1 0.9 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESS67196.1 - 3.4e-22 78.6 0.0 1.9e-08 34.1 0.0 4.9 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.24 ESS67196.1 - 1e-07 32.2 0.1 0.075 13.2 0.0 4.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS67196.1 - 1.3e-06 28.5 10.1 0.038 13.9 0.0 6.5 6 1 1 7 7 6 2 AAA ATPase domain AAA_22 PF13401.1 ESS67196.1 - 1.3e-06 28.6 0.6 1.4 9.0 0.0 5.4 4 0 0 4 4 4 2 AAA domain AAA_19 PF13245.1 ESS67196.1 - 5.1e-05 22.9 0.8 5.6 6.7 0.0 3.8 3 0 0 3 3 3 1 Part of AAA domain AAA_18 PF13238.1 ESS67196.1 - 0.00017 21.8 0.3 6.1 7.1 0.0 5.5 5 0 0 5 5 3 1 AAA domain Mg_chelatase PF01078.16 ESS67196.1 - 0.00043 19.5 0.2 0.11 11.6 0.0 3.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 ESS67196.1 - 0.0011 19.1 0.5 12 6.1 0.0 4.7 4 0 0 4 4 4 0 RNA helicase AAA_17 PF13207.1 ESS67196.1 - 0.0013 19.4 0.1 0.67 10.7 0.0 5.5 5 0 0 5 5 3 1 AAA domain PhoH PF02562.11 ESS67196.1 - 0.0018 17.5 0.6 2.3 7.4 0.0 3.5 3 0 0 3 3 3 1 PhoH-like protein UPF0079 PF02367.12 ESS67196.1 - 0.0087 15.6 1.9 17 5.0 0.0 4.4 4 0 0 4 4 4 0 Uncharacterised P-loop hydrolase UPF0079 ABC_tran PF00005.22 ESS67196.1 - 0.049 13.9 1.2 23 5.2 0.0 3.9 3 0 0 3 3 2 0 ABC transporter AAA_33 PF13671.1 ESS67196.1 - 0.065 13.1 4.0 24 4.8 0.0 5.4 6 0 0 6 6 6 0 AAA domain Reo_sigmaC PF04582.7 ESS67196.1 - 0.6 9.2 3.2 0.47 9.5 0.1 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DNA_pol_A PF00476.15 ESS67197.1 - 5e-31 107.6 0.5 1.4e-30 106.2 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 ESS67197.1 - 0.00018 21.0 0.0 0.0013 18.2 0.0 2.3 2 0 0 2 2 2 1 3'-5' exonuclease SE PF08491.5 ESS67198.1 - 4.3e-59 199.5 0.0 6.3e-59 199.0 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 ESS67198.1 - 9.5e-05 21.5 0.0 0.12 11.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 ESS67198.1 - 0.0055 16.7 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESS67198.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DAO PF01266.19 ESS67198.1 - 0.18 10.6 0.0 0.29 10.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Kinesin PF00225.18 ESS67199.1 - 6.6e-92 307.7 0.1 1.5e-91 306.6 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain SAM_1 PF00536.25 ESS67199.1 - 1.7e-05 24.9 2.6 1.8e-05 24.8 0.4 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESS67199.1 - 0.00061 19.5 0.4 0.0014 18.3 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Tcp10_C PF07202.8 ESS67200.1 - 8e-28 97.1 0.0 1.7e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 T-complex protein 10 C-terminus PSI_PsaF PF02507.10 ESS67200.1 - 0.13 11.8 0.1 0.36 10.3 0.0 1.7 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Metallophos PF00149.23 ESS67201.1 - 1.3e-24 86.6 0.2 2e-24 86.1 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Coatomer_WDAD PF04053.9 ESS67202.1 - 0.027 13.2 0.0 0.062 12.0 0.0 1.5 1 0 0 1 1 1 0 Coatomer WD associated region RRM_1 PF00076.17 ESS67203.1 - 3.4e-10 39.4 0.0 4e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67203.1 - 3.4e-06 26.9 0.1 2e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) E1-E2_ATPase PF00122.15 ESS67204.1 - 1.3e-18 66.9 0.0 2.4e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESS67204.1 - 4.2e-14 53.4 0.0 1.3e-12 48.6 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS67204.1 - 2.5e-11 44.1 0.0 6e-11 42.8 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS67204.1 - 7.1e-11 41.9 0.0 4.5e-10 39.3 0.0 2.2 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit S4_2 PF13275.1 ESS67204.1 - 0.0093 15.5 0.3 0.026 14.1 0.2 1.7 1 0 0 1 1 1 1 S4 domain AAA PF00004.24 ESS67205.1 - 3.2e-11 43.5 0.0 7.5e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS67205.1 - 0.00079 20.2 0.1 0.065 14.0 0.0 3.6 3 1 0 3 3 3 1 AAA domain RuvB_N PF05496.7 ESS67205.1 - 0.008 15.2 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IQ PF00612.22 ESS67205.1 - 0.011 15.2 0.3 0.011 15.2 0.2 3.0 3 0 0 3 3 3 0 IQ calmodulin-binding motif AAA_16 PF13191.1 ESS67205.1 - 0.028 14.4 1.1 0.21 11.5 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.14 ESS67205.1 - 0.037 13.4 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 ESS67205.1 - 0.04 13.3 3.0 0.098 12.1 0.0 2.9 4 0 0 4 4 4 0 FtsK/SpoIIIE family AAA_33 PF13671.1 ESS67205.1 - 0.048 13.5 0.0 0.23 11.3 0.0 2.2 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 ESS67205.1 - 0.067 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Lactamase_B PF00753.22 ESS67206.1 - 1.9e-06 27.7 0.8 0.0056 16.3 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESS67206.1 - 2.6e-06 27.1 0.0 5.3e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain DRMBL PF07522.9 ESS67206.1 - 0.072 13.1 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Laminin_G_3 PF13385.1 ESS67207.1 - 4.6e-06 26.9 0.0 3.3e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily HECT PF00632.20 ESS67209.1 - 1e-53 182.5 0.0 1.9e-53 181.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.23 ESS67209.1 - 1.4e-33 115.6 0.3 5e-17 62.1 0.0 2.7 2 0 0 2 2 2 2 SPRY domain DUF566 PF04484.7 ESS67210.1 - 2.2 7.7 8.5 3.5 7.0 5.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) ABC2_membrane_3 PF12698.2 ESS67213.1 - 3.3e-54 184.2 54.2 1.2e-37 129.7 13.6 2.1 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.22 ESS67213.1 - 2.8e-27 95.6 0.0 5.1e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS67213.1 - 2e-08 34.5 0.1 5.7e-05 23.2 0.0 2.8 2 1 1 3 3 3 2 AAA domain AAA_23 PF13476.1 ESS67213.1 - 0.00075 19.8 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 ESS67213.1 - 0.0018 17.5 0.0 0.12 11.6 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESS67213.1 - 0.0027 17.2 0.0 0.0072 15.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ESS67213.1 - 0.0057 15.8 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SbcCD_C PF13558.1 ESS67213.1 - 0.0069 16.2 0.0 0.035 14.0 0.0 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC2_membrane_4 PF12730.2 ESS67213.1 - 0.024 13.7 53.3 0.26 10.4 17.3 2.5 2 1 0 2 2 2 0 ABC-2 family transporter protein MukB PF04310.7 ESS67213.1 - 0.076 12.3 0.2 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 MukB N-terminal AAA_30 PF13604.1 ESS67213.1 - 0.1 12.1 0.0 0.29 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain PDR_CDR PF06422.7 ESS67213.1 - 0.73 9.5 7.8 0.81 9.3 0.5 2.8 2 0 0 2 2 2 0 CDR ABC transporter ABC_tran PF00005.22 ESS67214.1 - 1.9e-24 86.5 0.0 3.7e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS67214.1 - 9.2e-08 32.3 0.0 1.5e-05 25.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.17 ESS67214.1 - 0.0014 18.1 0.1 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA PF00004.24 ESS67214.1 - 0.068 13.3 0.1 0.42 10.8 0.1 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 ESS67214.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESS67214.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B LRR_4 PF12799.2 ESS67215.1 - 2.7e-14 52.3 0.3 9.9e-06 25.0 0.0 2.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS67215.1 - 9.6e-05 21.9 3.9 1.4 9.2 0.3 4.8 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_8 PF13855.1 ESS67215.1 - 0.00026 20.6 3.9 0.0059 16.3 0.4 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_7 PF13504.1 ESS67215.1 - 0.00075 19.2 2.7 7.4 7.2 0.1 4.3 3 0 0 3 3 3 1 Leucine rich repeat LRR_6 PF13516.1 ESS67215.1 - 0.015 15.3 0.1 1.2 9.3 0.1 3.1 2 1 0 2 2 2 0 Leucine Rich repeat LRR_9 PF14580.1 ESS67215.1 - 0.096 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat WD40 PF00400.27 ESS67219.1 - 0.00036 20.2 7.0 0.17 11.8 0.1 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat EMP70 PF02990.11 ESS67221.1 - 4.8e-93 312.3 16.1 2.1e-91 306.9 11.2 2.0 1 1 0 1 1 1 1 Endomembrane protein 70 GP41 PF00517.12 ESS67221.1 - 1.4 8.4 2.9 25 4.3 0.7 2.4 2 0 0 2 2 2 0 Retroviral envelope protein Sin_N PF04801.8 ESS67222.1 - 3.5e-129 431.3 0.0 5.8e-129 430.6 0.0 1.3 1 0 0 1 1 1 1 Sin-like protein conserved region Lin0512_fam PF09585.5 ESS67223.1 - 0.013 15.0 0.2 0.034 13.6 0.2 1.7 1 0 0 1 1 1 0 Conserved hypothetical protein (Lin0512_fam) Med11 PF10280.4 ESS67223.1 - 0.12 12.4 5.4 0.42 10.6 3.7 2.1 1 1 0 1 1 1 0 Mediator complex protein PhaC_N PF07167.8 ESS67223.1 - 0.41 10.0 3.1 0.53 9.7 0.1 2.6 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus FliE PF02049.13 ESS67223.1 - 5 7.2 20.4 6.1 6.9 2.7 4.2 2 1 2 4 4 4 0 Flagellar hook-basal body complex protein FliE Dpy-30 PF05186.8 ESS67224.1 - 7.1e-17 60.6 0.1 1.3e-16 59.7 0.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif AAA_17 PF13207.1 ESS67224.1 - 0.00011 23.0 4.6 0.00013 22.7 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_28 PF13521.1 ESS67224.1 - 0.00051 20.0 0.0 0.00051 20.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain RIIa PF02197.12 ESS67224.1 - 0.00063 19.1 0.0 0.0022 17.3 0.0 2.0 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Epimerase PF01370.16 ESS67224.1 - 0.001 18.5 0.0 0.005 16.3 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADK PF00406.17 ESS67224.1 - 0.0025 17.6 0.1 0.18 11.6 0.0 3.4 4 0 0 4 4 4 1 Adenylate kinase AAA PF00004.24 ESS67224.1 - 0.048 13.8 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESS67224.1 - 0.066 13.1 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESS67224.1 - 0.071 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 ESS67224.1 - 0.28 11.4 0.0 0.28 11.4 0.0 4.2 5 1 0 5 5 5 0 AAA domain FKBP_C PF00254.23 ESS67225.1 - 3.1e-07 30.2 0.0 1.4e-06 28.1 0.0 2.1 1 1 1 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase Yae1_N PF09811.4 ESS67226.1 - 0.11 12.0 2.5 0.2 11.2 1.7 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Gtr1_RagA PF04670.7 ESS67227.1 - 1.3e-92 309.1 0.0 2.5e-92 308.2 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ras PF00071.17 ESS67227.1 - 4.5e-06 26.1 0.0 8.5e-06 25.2 0.0 1.6 1 1 0 1 1 1 1 Ras family Arf PF00025.16 ESS67227.1 - 0.00072 18.8 0.0 0.002 17.4 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Miro PF08477.8 ESS67227.1 - 0.0015 18.9 0.0 0.004 17.6 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein IPPT PF01715.12 ESS67227.1 - 0.061 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 IPP transferase GTP_EFTU PF00009.22 ESS67227.1 - 0.11 11.9 0.0 0.44 9.9 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Ribosomal_L44 PF00935.14 ESS67228.1 - 7.4e-32 109.1 7.8 1.1e-31 108.6 5.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 RNHCP PF12647.2 ESS67228.1 - 0.35 10.7 3.0 0.58 10.0 0.1 2.0 1 1 1 2 2 2 0 RNHCP domain DUF2189 PF09955.4 ESS67230.1 - 0.0044 16.9 0.6 0.01 15.8 0.4 1.5 1 0 0 1 1 1 1 Predicted integral membrane protein (DUF2189) Surfac_D-trimer PF09006.6 ESS67230.1 - 3.2 7.5 7.8 4.6 7.0 0.1 3.9 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation Ran_BP1 PF00638.13 ESS67231.1 - 4e-29 101.1 0.9 5e-29 100.8 0.6 1.1 1 0 0 1 1 1 1 RanBP1 domain EF-hand_8 PF13833.1 ESS67232.1 - 2e-13 49.7 0.5 2.4e-06 27.0 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS67232.1 - 8e-10 37.3 0.1 0.003 16.7 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 ESS67232.1 - 1e-09 38.4 1.0 0.00072 19.6 0.6 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS67232.1 - 1.6e-07 30.5 0.8 0.53 10.3 0.1 4.2 3 1 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 ESS67232.1 - 0.00098 18.3 0.2 0.0098 15.2 0.1 2.6 2 0 0 2 2 2 1 EF hand UQ_con PF00179.21 ESS67233.1 - 2.5e-17 62.6 0.0 2.6e-17 62.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESS67233.1 - 0.0028 17.5 0.0 0.003 17.4 0.0 1.2 1 0 0 1 1 1 1 RWD domain Oxidored_q3 PF00499.15 ESS67243.1 - 0.15 11.7 10.6 0.2 11.4 7.3 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF3671 PF12420.3 ESS67243.1 - 0.27 11.2 12.0 0.34 10.9 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function DnaJ PF00226.26 ESS67244.1 - 1.1e-12 47.5 0.0 2.2e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain 7tm_1 PF00001.16 ESS67244.1 - 0.011 14.8 0.7 0.077 12.1 0.0 2.1 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) CLPTM1 PF05602.7 ESS67246.1 - 6.1e-120 400.8 1.1 7.3e-120 400.6 0.8 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) peroxidase PF00141.18 ESS67247.1 - 1.6e-42 145.5 0.0 2.9e-42 144.7 0.0 1.4 1 1 0 1 1 1 1 Peroxidase MTHFR_C PF12225.3 ESS67247.1 - 0.045 13.2 0.0 0.096 12.1 0.0 1.5 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal Nucleoporin_C PF03177.9 ESS67249.1 - 0.062 11.8 0.6 0.32 9.4 0.0 2.0 1 1 1 2 2 2 0 Non-repetitive/WGA-negative nucleoporin C-terminal PCI PF01399.22 ESS67250.1 - 5.1e-07 29.9 0.1 7.8e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 PCI domain Herpes_UL52 PF03121.10 ESS67252.1 - 2.3e-05 24.0 1.6 3.6e-05 23.4 1.1 1.3 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase Ldh_1_N PF00056.18 ESS67253.1 - 4.6e-14 52.4 0.0 7.9e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 ESS67253.1 - 3.8e-13 49.5 0.0 2.9e-05 23.8 0.0 2.2 2 0 0 2 2 2 2 lactate/malate dehydrogenase, alpha/beta C-terminal domain THF_DHG_CYH_C PF02882.14 ESS67253.1 - 0.048 12.7 0.3 0.19 10.8 0.0 2.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Me-amine-dh_L PF02975.9 ESS67253.1 - 0.14 12.1 0.3 0.27 11.1 0.2 1.4 1 0 0 1 1 1 0 Methylamine dehydrogenase, L chain Ldh_1_N PF00056.18 ESS67254.1 - 1.4e-44 151.3 0.0 2.4e-44 150.5 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 ESS67254.1 - 1.7e-40 138.5 0.0 2.4e-40 138.0 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 ESS67254.1 - 0.0046 15.6 0.0 0.0065 15.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 ESS67254.1 - 0.02 14.8 0.0 0.051 13.5 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.19 ESS67254.1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_hydro_38 PF01074.17 ESS67255.1 - 9.9e-65 218.5 5.5 1.4e-64 217.9 3.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 ESS67255.1 - 2.5e-40 138.6 0.1 3.1e-40 138.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 ESS67255.1 - 3.7e-20 71.9 0.0 8e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase, middle domain Nop25 PF09805.4 ESS67256.1 - 6.8e-12 45.6 2.8 6.8e-12 45.6 1.9 2.4 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) BTV_NS2 PF04514.7 ESS67256.1 - 0.11 11.3 4.5 0.17 10.6 3.1 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Methyltransf_26 PF13659.1 ESS67257.1 - 8e-09 35.5 0.5 1.8e-07 31.2 0.4 2.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS67257.1 - 7.4e-07 29.7 0.0 1.7e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS67257.1 - 0.00072 19.8 0.1 0.0019 18.5 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS67257.1 - 0.001 18.6 0.0 0.0041 16.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESS67257.1 - 0.0011 18.3 0.1 0.0028 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 ESS67257.1 - 0.0057 17.1 0.0 0.022 15.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS67257.1 - 0.01 16.3 0.0 0.026 14.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 ESS67257.1 - 0.022 15.5 0.2 0.13 13.0 0.1 2.5 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.1 ESS67257.1 - 0.031 14.0 0.0 0.19 11.4 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DUF633 PF04816.7 ESS67257.1 - 0.077 12.3 0.1 0.39 10.0 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF633) PrmA PF06325.8 ESS67257.1 - 0.15 11.1 0.1 0.28 10.2 0.1 1.5 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Atg14 PF10186.4 ESS67259.1 - 0.17 10.7 4.2 0.29 10.0 2.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1192 PF06698.6 ESS67259.1 - 0.6 9.9 7.5 0.17 11.7 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF964 PF06133.6 ESS67259.1 - 0.96 9.4 5.7 0.32 11.0 0.3 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF964) DUF1935 PF09149.5 ESS67260.1 - 6.1e-116 379.5 1.0 5.9e-29 100.1 0.0 4.0 4 0 0 4 4 4 4 Domain of unknown function (DUF1935) Ist1 PF03398.9 ESS67261.1 - 1.6e-59 200.0 0.3 2e-59 199.6 0.2 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway zf-C2H2_4 PF13894.1 ESS67262.1 - 0.25 11.7 0.2 0.61 10.5 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger Seryl_tRNA_N PF02403.17 ESS67262.1 - 2.8 8.0 41.7 0.064 13.2 0.6 5.3 2 2 4 6 6 6 0 Seryl-tRNA synthetase N-terminal domain TMF_DNA_bd PF12329.3 ESS67264.1 - 0.0093 15.7 7.3 0.0093 15.7 5.1 5.5 4 2 0 4 4 4 1 TATA element modulatory factor 1 DNA binding Pyr_redox_2 PF07992.9 ESS67266.1 - 1.2e-09 38.3 0.0 4.8e-08 33.1 0.0 2.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESS67266.1 - 4.8e-05 22.4 0.1 7.1e-05 21.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 ESS67266.1 - 0.0046 16.9 0.0 0.019 14.9 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 ESS67266.1 - 0.0054 15.6 0.2 0.0089 14.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 ESS67266.1 - 0.0055 15.6 0.1 0.0097 14.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 ESS67266.1 - 0.012 14.1 0.0 0.019 13.4 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein ApbA PF02558.11 ESS67266.1 - 0.015 14.7 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.12 ESS67266.1 - 0.053 12.6 0.0 0.093 11.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.22 ESS67266.1 - 0.063 13.6 0.1 0.18 12.2 0.1 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 ESS67266.1 - 0.11 11.0 0.1 0.19 10.3 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Mqo PF06039.10 ESS67266.1 - 0.16 10.1 0.0 0.23 9.5 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) 2-Hacid_dh_C PF02826.14 ESS67266.1 - 0.17 11.0 0.0 0.61 9.2 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Mon1 PF03164.9 ESS67267.1 - 6.8e-40 136.9 0.8 2.2e-38 131.9 0.1 2.6 2 1 0 2 2 2 2 Trafficking protein Mon1 WD40 PF00400.27 ESS67268.1 - 1.6e-20 72.1 5.1 4.7e-05 23.1 0.1 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.3 ESS67268.1 - 0.035 12.2 0.1 4.7 5.2 0.1 2.4 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Flavi_DEAD PF07652.9 ESS67269.1 - 0.0092 15.7 0.1 0.021 14.6 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain Cep57_MT_bd PF06657.8 ESS67269.1 - 3 7.8 10.9 1.2 9.1 0.3 4.1 4 1 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 PseudoU_synth_1 PF01416.15 ESS67270.1 - 3.1e-19 69.3 0.0 2.8e-10 40.5 0.0 2.8 2 1 0 2 2 2 2 tRNA pseudouridine synthase START PF01852.14 ESS67271.1 - 1.7e-08 34.0 0.0 2.7e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 START domain DUF1479 PF07350.7 ESS67272.1 - 1e-141 472.2 0.0 1.2e-141 471.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.8 ESS67272.1 - 0.00015 21.8 0.0 0.013 15.5 0.0 2.6 2 2 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) PG_binding_2 PF08823.6 ESS67272.1 - 0.02 14.9 0.1 0.1 12.7 0.0 2.2 2 0 0 2 2 2 0 Putative peptidoglycan binding domain DS PF01916.12 ESS67273.1 - 1.3e-63 214.8 0.0 4.5e-53 180.3 0.0 3.1 3 0 0 3 3 3 3 Deoxyhypusine synthase AAA_16 PF13191.1 ESS67275.1 - 1.6e-05 24.9 0.1 4.6e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 ESS67275.1 - 6.4e-05 23.1 0.0 0.00047 20.3 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS67275.1 - 0.00048 20.9 0.0 0.00086 20.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS67275.1 - 0.0023 18.0 0.0 0.0071 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESS67275.1 - 0.0023 17.6 0.0 0.004 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESS67275.1 - 0.0042 16.9 0.0 0.0068 16.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS67275.1 - 0.012 15.2 0.2 0.034 13.8 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_11 PF13086.1 ESS67275.1 - 0.026 14.1 0.4 0.088 12.3 0.2 1.8 1 1 0 1 1 1 0 AAA domain CPT PF07931.7 ESS67275.1 - 0.029 13.9 0.0 0.075 12.6 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.1 ESS67275.1 - 0.06 13.6 0.0 0.19 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Torsin PF06309.6 ESS67275.1 - 0.072 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Torsin Zeta_toxin PF06414.7 ESS67275.1 - 0.076 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF815 PF05673.8 ESS67275.1 - 0.089 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Viral_helicase1 PF01443.13 ESS67275.1 - 0.091 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase eIF-5_eIF-2B PF01873.12 ESS67276.1 - 1.9e-32 111.5 0.1 3.5e-32 110.7 0.1 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 ESS67276.1 - 0.0014 18.5 0.0 0.0038 17.1 0.0 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon zf-CHY PF05495.7 ESS67276.1 - 0.076 13.1 0.2 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 CHY zinc finger DUF3133 PF11331.3 ESS67276.1 - 0.34 10.4 3.2 1.4 8.5 2.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3133) RNA_pol_Rpb1_5 PF04998.12 ESS67277.1 - 2e-84 283.1 0.0 7.9e-84 281.1 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ESS67277.1 - 2.5e-63 212.9 0.0 4.8e-63 212.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.7 ESS67277.1 - 5.4e-57 193.5 0.0 4.1e-56 190.6 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.13 ESS67277.1 - 1.5e-32 112.4 0.0 4.3e-32 111.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESS67277.1 - 6e-32 109.6 0.3 2.4e-31 107.6 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 DUF3306 PF11748.3 ESS67277.1 - 0.098 13.3 0.5 0.22 12.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) COG6 PF06419.6 ESS67278.1 - 1.6e-37 128.9 1.7 3.1e-33 114.8 0.2 2.3 2 0 0 2 2 2 2 Conserved oligomeric complex COG6 RNase_HII PF01351.13 ESS67278.1 - 0.015 14.9 0.4 0.12 12.0 0.0 2.4 3 0 0 3 3 3 0 Ribonuclease HII RRF PF01765.14 ESS67279.1 - 0.0054 16.2 2.5 0.0054 16.2 1.7 1.6 2 0 0 2 2 2 1 Ribosome recycling factor DUF2392 PF10288.4 ESS67279.1 - 0.11 12.8 0.1 0.54 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2392) DUF2678 PF10856.3 ESS67281.1 - 0.088 12.5 1.0 16 5.2 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) DUF2388 PF09498.5 ESS67282.1 - 0.11 12.1 0.2 0.31 10.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) WD40 PF00400.27 ESS67283.1 - 1.1e-61 202.6 29.7 1.1e-12 47.2 0.2 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 ESS67283.1 - 0.00098 18.8 0.0 0.012 15.2 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Hex_IIIa PF02455.11 ESS67283.1 - 5.1 5.6 8.6 7.3 5.1 5.9 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) ENTH PF01417.15 ESS67284.1 - 0.0016 18.2 0.8 0.019 14.7 0.0 2.7 3 0 0 3 3 3 1 ENTH domain Ion_trans PF00520.26 ESS67285.1 - 2e-45 154.5 57.4 2e-32 112.0 10.7 2.9 3 0 0 3 3 3 2 Ion transport protein DUF4191 PF13829.1 ESS67285.1 - 0.019 14.1 1.3 0.068 12.2 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Ion_trans PF00520.26 ESS67286.1 - 6.1e-36 123.5 36.0 3.7e-34 117.7 11.0 3.3 4 0 0 4 4 4 2 Ion transport protein DUF1279 PF06916.8 ESS67286.1 - 0.0082 16.4 0.5 0.049 13.9 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Ion_trans PF00520.26 ESS67287.1 - 9.4e-17 60.9 3.9 1.4e-16 60.3 2.7 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 ESS67287.1 - 0.55 8.6 4.8 0.8 8.0 3.3 1.3 1 0 0 1 1 1 0 Polycystin cation channel Enolase_C PF00113.17 ESS67288.1 - 6.4e-133 442.2 0.0 8.5e-133 441.8 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 ESS67288.1 - 1.1e-58 196.8 0.0 1.9e-58 196.1 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 ESS67288.1 - 9.2e-05 22.3 0.0 0.00078 19.3 0.0 2.3 2 0 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.6 ESS67288.1 - 0.001 18.0 0.1 0.0023 16.9 0.1 1.6 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus MR_MLE PF01188.16 ESS67288.1 - 0.041 14.4 0.0 0.11 13.0 0.0 1.8 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain DUF576 PF04507.7 ESS67288.1 - 0.11 11.3 0.1 0.2 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF576 HEAT_EZ PF13513.1 ESS67289.1 - 1.3e-09 38.2 1.8 0.033 14.6 0.0 5.4 5 2 2 7 7 7 3 HEAT-like repeat HEAT_2 PF13646.1 ESS67289.1 - 1.4e-08 34.8 0.0 0.16 12.2 0.0 4.2 3 1 0 3 3 3 3 HEAT repeats HEAT PF02985.17 ESS67289.1 - 0.0062 16.5 3.1 82 3.6 0.0 6.5 7 0 0 7 7 7 0 HEAT repeat DUF3677 PF12432.3 ESS67289.1 - 0.04 14.3 0.3 0.49 10.8 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3677) U3snoRNP10 PF12397.3 ESS67289.1 - 0.069 13.1 2.1 1.1 9.2 0.0 3.7 3 1 1 4 4 4 0 U3 small nucleolar RNA-associated protein 10 Cnd1 PF12717.2 ESS67289.1 - 0.11 12.2 2.8 0.99 9.2 0.0 3.7 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Senescence_reg PF04520.8 ESS67292.1 - 6.7 7.1 18.0 0.034 14.6 2.6 3.8 5 0 0 5 5 5 0 Senescence regulator SNAP PF14938.1 ESS67293.1 - 1.6e-09 37.3 14.2 0.0045 16.1 3.3 3.3 2 1 2 4 4 4 3 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 ESS67293.1 - 0.0023 17.6 0.4 0.86 9.5 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS67293.1 - 0.004 16.8 0.3 3.9 7.4 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS67293.1 - 0.011 16.2 2.8 1.2 10.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS67293.1 - 0.016 15.9 0.8 3.1 8.5 0.0 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS67293.1 - 0.017 15.0 1.0 2.2 8.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESS67293.1 - 0.073 12.7 2.2 5.3 6.7 0.1 3.0 3 0 0 3 3 3 0 TPR repeat GTP_EFTU PF00009.22 ESS67296.1 - 7.5e-46 155.9 0.0 1.1e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 ESS67296.1 - 2.1e-29 101.5 2.0 3.7e-29 100.7 1.4 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 ESS67296.1 - 4.5e-13 48.8 0.0 1e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 ESS67296.1 - 3.1e-05 23.9 0.0 6.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESS67296.1 - 0.049 14.1 0.0 0.092 13.2 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein Ras PF00071.17 ESS67296.1 - 0.13 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Ras family SRPRB PF09439.5 ESS67296.1 - 0.13 11.4 0.0 0.3 10.2 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FOP_dimer PF09398.5 ESS67298.1 - 0.011 15.6 0.0 0.042 13.8 0.0 2.0 2 0 0 2 2 2 0 FOP N terminal dimerisation domain Vac_Fusion PF02346.11 ESS67300.1 - 5 6.6 7.4 0.62 9.5 1.4 2.3 2 0 0 2 2 2 0 Chordopoxvirus fusion protein Phage_Gp23 PF10669.4 ESS67301.1 - 0.0077 16.3 0.3 0.0077 16.3 0.2 4.1 5 0 0 5 5 5 1 Protein gp23 (Bacteriophage A118) Reo_sigmaC PF04582.7 ESS67301.1 - 0.38 9.8 6.0 2.2 7.3 0.1 2.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein JAB PF01398.16 ESS67302.1 - 5.4e-31 106.7 0.0 8.2e-31 106.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESS67302.1 - 1.4e-09 37.4 0.0 2.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.1 ESS67302.1 - 2.1e-08 34.2 0.0 4.6e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.8 ESS67302.1 - 0.0032 16.9 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) ADK PF00406.17 ESS67303.1 - 7.2e-24 84.3 0.0 8.5e-24 84.1 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 ESS67303.1 - 2.8e-14 52.4 0.0 6.4e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 ESS67303.1 - 2.6e-07 31.4 0.1 2.3e-06 28.4 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESS67303.1 - 0.0026 18.0 0.0 0.0052 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS67303.1 - 0.0027 17.5 0.0 0.006 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS67303.1 - 0.0067 16.1 0.0 0.018 14.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 ESS67303.1 - 0.016 14.2 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESS67303.1 - 0.017 14.8 0.0 0.039 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ESS67303.1 - 0.061 12.4 0.0 0.2 10.7 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.1 ESS67303.1 - 0.095 12.6 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESS67303.1 - 0.1 12.5 0.3 0.17 11.8 0.1 1.7 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.24 ESS67303.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS67303.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain HPP PF04982.8 ESS67304.1 - 4.6e-31 107.1 7.6 4.6e-31 107.1 5.3 1.6 2 0 0 2 2 2 1 HPP family CS PF04969.11 ESS67305.1 - 3.9e-11 43.3 0.0 6.5e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 CS domain SlyX PF04102.7 ESS67306.1 - 0.00048 20.4 1.3 0.0012 19.2 0.2 2.0 1 1 1 2 2 2 1 SlyX NPV_P10 PF05531.7 ESS67306.1 - 0.039 14.2 0.3 0.063 13.5 0.2 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.1 ESS67306.1 - 0.045 14.0 2.2 0.078 13.2 1.5 1.4 1 1 0 1 1 1 0 Snapin/Pallidin Seryl_tRNA_N PF02403.17 ESS67306.1 - 0.049 13.6 8.8 0.07 13.1 6.0 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Ax_dynein_light PF10211.4 ESS67306.1 - 0.079 12.7 6.3 0.098 12.4 4.4 1.2 1 1 0 1 1 1 0 Axonemal dynein light chain DUF4446 PF14584.1 ESS67306.1 - 0.15 11.8 2.8 0.2 11.4 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) PRP1_N PF06424.7 ESS67306.1 - 0.35 11.1 5.1 0.43 10.8 3.6 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF2346 PF09803.4 ESS67306.1 - 0.49 10.2 2.8 0.64 9.9 1.4 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2346) DUF2570 PF10828.3 ESS67306.1 - 3.1 7.4 5.4 12 5.5 3.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) IATP PF04568.7 ESS67306.1 - 4.4 7.4 8.3 55 3.8 5.8 2.3 1 1 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Ribosomal_S25 PF03297.10 ESS67308.1 - 4.5e-39 132.7 3.3 5.1e-39 132.5 2.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein DUF3516 PF12029.3 ESS67308.1 - 0.07 11.9 0.3 0.067 11.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) EAP30 PF04157.11 ESS67308.1 - 0.082 12.0 0.1 5.3 6.1 0.0 2.0 1 1 1 2 2 2 0 EAP30/Vps36 family ADK PF00406.17 ESS67309.1 - 4.7e-51 172.6 0.0 5.6e-51 172.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 ESS67309.1 - 7.8e-15 54.2 0.0 1.9e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 ESS67309.1 - 2.5e-07 31.5 0.0 5.8e-07 30.3 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 ESS67309.1 - 0.0014 18.5 0.1 0.0091 15.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESS67309.1 - 0.062 13.2 0.2 0.23 11.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain Abi PF02517.11 ESS67314.1 - 6e-18 64.7 3.7 6.1e-18 64.7 1.6 1.7 2 0 0 2 2 2 1 CAAX protease self-immunity Rab3-GTPase_cat PF13890.1 ESS67315.1 - 9e-50 168.2 0.0 1.4e-49 167.6 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Na_H_Exchanger PF00999.16 ESS67315.1 - 0.17 10.3 0.0 0.28 9.6 0.0 1.2 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family Nol1_Nop2_Fmu PF01189.12 ESS67316.1 - 9.1e-14 51.4 0.0 4.5e-08 32.8 0.0 2.1 2 0 0 2 2 2 2 NOL1/NOP2/sun family PUA PF01472.15 ESS67316.1 - 2.7e-07 30.2 2.1 7.6e-07 28.7 1.4 1.8 1 1 0 1 1 1 1 PUA domain Nuc_sug_transp PF04142.10 ESS67317.1 - 0.041 12.9 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-sugar transporter Pkinase PF00069.20 ESS67319.1 - 5.5e-32 110.9 0.0 7.7e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67319.1 - 1.6e-22 79.8 0.0 2e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS67319.1 - 4.3e-05 22.6 0.0 5.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS67319.1 - 0.0021 17.8 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESS67319.1 - 0.11 11.7 0.0 0.45 9.8 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Pkinase PF00069.20 ESS67320.1 - 0.022 13.9 0.8 0.028 13.5 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain NARP1 PF12569.3 ESS67320.1 - 0.037 12.7 2.1 0.048 12.4 1.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FRG2 PF15315.1 ESS67320.1 - 0.054 13.4 4.2 0.096 12.6 2.9 1.4 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 PI3_PI4_kinase PF00454.22 ESS67323.1 - 0.0059 16.0 0.1 0.0086 15.5 0.0 1.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF2654 PF10849.3 ESS67323.1 - 0.025 14.3 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2654) ABC_ATPase PF09818.4 ESS67324.1 - 5.5e-170 565.7 0.0 7e-170 565.4 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class PAC2 PF09754.4 ESS67324.1 - 0.022 14.6 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 PAC2 family AAA_23 PF13476.1 ESS67324.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS67324.1 - 0.14 12.4 0.1 12 6.2 0.0 2.3 1 1 1 2 2 2 0 ABC transporter FoP_duplication PF13865.1 ESS67324.1 - 0.23 11.9 0.5 0.46 10.9 0.4 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Pkinase PF00069.20 ESS67325.1 - 5.5e-35 120.7 0.0 5.7e-28 97.7 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67325.1 - 0.00025 20.2 0.0 0.3 10.1 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Auxin_inducible PF02519.9 ESS67325.1 - 0.23 11.5 1.4 2.8 8.0 0.0 2.6 2 0 0 2 2 2 0 Auxin responsive protein TRAPPC-Trs85 PF12739.2 ESS67327.1 - 1.4e-48 165.5 0.0 2.1e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_12 PF13424.1 ESS67327.1 - 0.00071 19.4 1.1 0.083 12.8 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS67327.1 - 0.0022 17.5 0.6 0.29 10.8 0.0 2.5 2 0 0 2 2 2 1 TPR repeat TPR_7 PF13176.1 ESS67327.1 - 0.003 17.2 1.1 4.3 7.3 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS67327.1 - 0.012 15.3 2.2 1 9.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Sen15 PF09631.5 ESS67327.1 - 0.028 14.6 0.0 0.075 13.2 0.0 1.7 1 0 0 1 1 1 0 Sen15 protein TPR_2 PF07719.12 ESS67327.1 - 0.033 14.0 0.8 13 5.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS67327.1 - 0.21 11.2 4.5 2.9 7.6 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat BRCT PF00533.21 ESS67329.1 - 1.3e-10 41.2 0.0 0.0024 17.9 0.0 4.3 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain WD40 PF00400.27 ESS67330.1 - 1e-17 63.2 8.2 0.017 14.9 0.0 9.4 11 0 0 11 11 11 5 WD domain, G-beta repeat eIF2A PF08662.6 ESS67330.1 - 0.001 18.8 0.0 0.006 16.3 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A JAB PF01398.16 ESS67331.1 - 2.1e-06 27.4 0.0 4.7e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.8 ESS67331.1 - 0.028 13.9 0.2 0.55 9.6 0.0 2.3 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0172) DUF2242 PF10001.4 ESS67331.1 - 0.16 11.8 1.2 1.3 8.9 0.0 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2242) DUF1016 PF06250.6 ESS67332.1 - 0.008 15.1 0.7 0.013 14.4 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1016) ART PF01129.13 ESS67333.1 - 0.0067 15.5 0.0 0.02 14.0 0.0 1.7 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase DUF3813 PF12758.2 ESS67333.1 - 0.0079 16.3 0.0 0.022 14.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3813) HSCB_C PF07743.8 ESS67334.1 - 1.3e-06 28.7 0.1 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 ESS67334.1 - 2.3e-06 27.2 0.2 1.3e-05 24.8 0.1 2.1 1 1 0 1 1 1 1 DnaJ domain AF0941-like PF14591.1 ESS67334.1 - 0.09 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 AF0941-like LRR_4 PF12799.2 ESS67335.1 - 2.3e-10 39.8 1.7 1.7e-06 27.4 0.3 3.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESS67335.1 - 2.5e-08 33.6 0.2 3.1e-07 30.1 0.0 2.3 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.1 ESS67335.1 - 2.3e-07 30.4 6.2 1.2e-05 24.9 0.7 3.1 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESS67335.1 - 0.00013 21.4 8.2 0.82 9.9 0.1 5.1 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 ESS67335.1 - 0.18 12.0 12.3 8.8 7.0 0.1 5.4 5 0 0 5 5 5 0 Leucine rich repeat LRR_6 PF13516.1 ESS67335.1 - 0.23 11.6 4.5 2.4 8.4 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich repeat Transket_pyr PF02779.19 ESS67336.1 - 2.6e-48 163.8 0.2 3.4e-48 163.4 0.1 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESS67336.1 - 4.6e-35 120.2 0.0 1.3e-34 118.7 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain Mannitol_dh_C PF08125.8 ESS67337.1 - 0.031 13.4 0.1 0.14 11.2 0.0 2.0 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain DUF3446 PF11928.3 ESS67339.1 - 4.3 7.6 9.3 0.16 12.2 0.9 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3446) Peptidase_S64 PF08192.6 ESS67340.1 - 2.4 6.3 7.5 2.6 6.2 5.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 Hamartin PF04388.7 ESS67340.1 - 3.7 6.0 17.4 4.2 5.9 12.0 1.1 1 0 0 1 1 1 0 Hamartin protein DUF1767 PF08585.7 ESS67341.1 - 0.00087 19.5 0.0 0.0021 18.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1767) Steroid_dh PF02544.11 ESS67342.1 - 1.5e-24 86.5 0.5 2e-24 86.0 0.3 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 ESS67342.1 - 0.0035 16.6 0.5 0.0052 16.1 0.3 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 ESS67342.1 - 0.048 13.7 4.1 1.1 9.3 0.9 2.3 1 1 1 2 2 2 0 Phospholipid methyltransferase GWT1 PF06423.7 ESS67342.1 - 0.093 12.8 0.4 0.093 12.8 0.3 1.7 2 0 0 2 2 2 0 GWT1 IncA PF04156.9 ESS67343.1 - 0.084 12.4 3.8 4.1 6.9 1.7 2.2 2 0 0 2 2 2 0 IncA protein Cob_adeno_trans PF01923.13 ESS67343.1 - 0.1 12.4 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase ATP-grasp_4 PF13535.1 ESS67344.1 - 1.3e-17 64.1 0.0 4.7e-17 62.3 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESS67344.1 - 4.1e-15 55.7 0.0 6.3e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus SET PF00856.23 ESS67344.1 - 3.4e-06 27.4 0.1 1.6e-05 25.2 0.0 2.1 3 0 0 3 3 3 1 SET domain ATPgrasp_Ter PF15632.1 ESS67344.1 - 1.8e-05 23.6 0.0 0.016 13.9 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.6 ESS67344.1 - 0.0001 21.8 0.0 0.0016 17.9 0.0 2.1 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 ESS67344.1 - 0.00011 22.0 0.0 0.00055 19.8 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 ESS67344.1 - 0.0055 16.0 0.0 0.02 14.2 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.14 ESS67344.1 - 0.045 13.3 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Herpes_capsid PF06112.6 ESS67344.1 - 0.48 10.4 9.5 0.77 9.7 6.6 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CHAP PF05257.11 ESS67346.1 - 2.7e-05 23.8 0.2 0.00026 20.6 0.0 2.1 2 0 0 2 2 2 1 CHAP domain Thioredoxin PF00085.15 ESS67349.1 - 0.00077 19.1 0.0 0.0017 18.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin DUF3456 PF11938.3 ESS67349.1 - 0.32 10.9 2.2 23 4.9 0.0 2.8 3 0 0 3 3 3 0 TLR4 regulator and MIR-interacting MSAP MRP-S31 PF15433.1 ESS67350.1 - 2.8 7.2 11.4 3.3 7.0 7.9 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 SLBP_RNA_bind PF15247.1 ESS67351.1 - 1.1e-24 85.9 2.3 4.1e-24 84.1 1.6 2.0 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain Not3 PF04065.10 ESS67352.1 - 2.2e-62 210.3 15.2 3.3e-62 209.8 10.5 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 ESS67352.1 - 6.4e-38 129.6 8.7 2.3e-37 127.8 6.0 2.0 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Cep57_MT_bd PF06657.8 ESS67352.1 - 0.12 12.3 1.9 0.3 11.0 0.6 2.3 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 WD40 PF00400.27 ESS67353.1 - 1.6e-25 87.9 4.9 1.6e-07 30.8 0.0 6.2 6 1 0 6 6 6 5 WD domain, G-beta repeat TPM PF04536.9 ESS67354.1 - 9e-15 54.5 0.0 1.6e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase DUF4543 PF15076.1 ESS67354.1 - 0.026 14.5 0.1 0.09 12.8 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) Colicin PF01024.14 ESS67354.1 - 0.033 13.7 0.1 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Colicin pore forming domain L6_membrane PF05805.7 ESS67354.1 - 0.037 13.5 0.9 0.06 12.8 0.1 1.7 2 0 0 2 2 2 0 L6 membrane protein DUF2387 PF09526.5 ESS67354.1 - 1.2 9.0 7.0 1.5 8.8 2.4 2.4 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Mut7-C PF01927.11 ESS67354.1 - 1.8 8.5 11.2 0.89 9.5 0.5 2.4 2 0 0 2 2 2 0 Mut7-C RNAse domain Caldesmon PF02029.10 ESS67355.1 - 0.012 14.1 1.7 0.015 13.7 1.2 1.2 1 0 0 1 1 1 0 Caldesmon Harakiri PF15196.1 ESS67355.1 - 0.38 11.0 0.1 0.38 11.0 0.1 2.2 3 0 0 3 3 3 0 Activator of apoptosis harakiri FlgN PF05130.7 ESS67355.1 - 0.5 10.5 5.9 4.4 7.5 0.3 3.3 4 0 0 4 4 4 0 FlgN protein FUSC PF04632.7 ESS67355.1 - 7.2 4.9 12.0 0.25 9.7 3.4 1.8 2 0 0 2 2 2 0 Fusaric acid resistance protein family CHB_HEX_C PF03174.8 ESS67356.1 - 5.1e-23 80.7 0.2 2.8e-10 39.8 0.1 3.4 2 1 1 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 ESS67356.1 - 6.3e-20 71.0 0.1 7.1e-09 35.6 0.0 3.4 3 0 0 3 3 3 2 Fn3 associated CHB_HEX_C_1 PF13290.1 ESS67356.1 - 6.5e-20 70.6 0.6 3e-09 36.5 0.1 3.4 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Ras PF00071.17 ESS67356.1 - 0.00071 18.9 0.0 0.0017 17.7 0.0 1.6 1 1 0 1 1 1 1 Ras family Peptidase_M32 PF02074.10 ESS67357.1 - 3.4e-97 326.1 0.5 1.2e-66 225.3 0.0 2.0 1 1 1 2 2 2 2 Carboxypeptidase Taq (M32) metallopeptidase DFP PF04127.10 ESS67358.1 - 3.3e-20 72.4 0.0 9e-11 41.7 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Borrelia_P83 PF05262.6 ESS67359.1 - 0.0027 16.0 4.2 0.0066 14.7 2.9 1.6 1 1 0 1 1 1 1 Borrelia P83/100 protein DNA_repr_REX1B PF14966.1 ESS67359.1 - 0.0036 17.6 1.1 0.0064 16.8 0.8 1.4 1 0 0 1 1 1 1 DNA repair REX1-B DUF3630 PF12305.3 ESS67359.1 - 0.062 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3630) PXA PF02194.10 ESS67359.1 - 0.13 11.7 6.0 3.2 7.2 4.1 2.4 1 1 0 1 1 1 0 PXA domain TPR_12 PF13424.1 ESS67360.1 - 6.1e-14 51.7 16.2 4.2e-06 26.6 0.2 3.9 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESS67360.1 - 5.3e-07 29.1 10.4 0.093 12.3 0.0 4.4 3 1 0 3 3 3 3 TPR repeat TPR_7 PF13176.1 ESS67360.1 - 1.5e-06 27.5 14.4 0.016 14.9 0.1 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS67360.1 - 0.00034 20.3 22.8 0.24 11.3 0.1 6.8 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS67360.1 - 0.0024 18.5 16.2 0.0032 18.1 0.2 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS67360.1 - 0.0038 16.9 8.9 0.24 11.2 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS67360.1 - 0.011 15.3 18.7 0.38 10.4 0.2 6.7 6 1 1 7 7 7 0 Tetratricopeptide repeat Cytochrom_C_2 PF01322.15 ESS67360.1 - 0.016 15.7 2.6 0.74 10.3 0.1 2.8 2 0 0 2 2 2 0 Cytochrome C' TPR_14 PF13428.1 ESS67360.1 - 0.058 14.0 24.8 3.3 8.5 0.3 7.1 6 1 1 7 7 7 0 Tetratricopeptide repeat Apc5 PF12862.2 ESS67360.1 - 0.061 13.1 3.1 0.062 13.1 0.3 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_9 PF13371.1 ESS67360.1 - 0.41 10.5 6.4 0.37 10.6 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS67360.1 - 1.1 9.2 8.3 20 5.2 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Urocanase PF01175.13 ESS67361.1 - 7e-129 430.3 0.1 8.1e-129 430.1 0.0 1.0 1 0 0 1 1 1 1 Urocanase DUF3135 PF11333.3 ESS67361.1 - 0.21 11.7 0.7 0.35 11.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Urocanase PF01175.13 ESS67362.1 - 3.8e-67 226.5 0.1 4.7e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Urocanase DUF479 PF04336.7 ESS67363.1 - 0.0035 17.4 1.6 0.0056 16.7 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF479 Kinesin PF00225.18 ESS67364.1 - 3.6e-79 265.8 2.3 4.3e-79 265.6 0.0 2.1 2 0 0 2 2 2 1 Kinesin motor domain DUF342 PF03961.8 ESS67364.1 - 0.7 8.2 5.3 3.4 5.9 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Kinesin PF00225.18 ESS67365.1 - 1.3e-105 352.7 4.1 1.6e-104 349.2 0.1 2.9 3 0 0 3 3 3 2 Kinesin motor domain AAA_22 PF13401.1 ESS67365.1 - 0.2 11.7 0.0 0.2 11.7 0.0 3.7 3 1 0 3 3 3 0 AAA domain tRNA-synt_1c PF00749.16 ESS67365.1 - 0.31 9.6 15.4 0.0061 15.2 4.9 2.4 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain Pkinase PF00069.20 ESS67367.1 - 1.3e-59 201.4 0.0 1e-58 198.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67367.1 - 9.7e-37 126.4 0.0 5.2e-34 117.4 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS67367.1 - 3.7e-05 22.8 0.0 0.00087 18.3 0.0 2.5 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESS67367.1 - 0.0094 15.6 0.3 0.02 14.6 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS67367.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family HpcH_HpaI PF03328.9 ESS67369.1 - 2.5e-59 199.8 0.0 2.9e-59 199.6 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Response_reg PF00072.19 ESS67369.1 - 0.0045 16.9 0.0 0.013 15.5 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain Peptidase_M24 PF00557.19 ESS67371.1 - 8.9e-42 143.0 0.0 1.3e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 ESS67371.1 - 4.3e-20 72.5 0.0 2.1e-15 57.3 0.0 2.6 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain Zeta_toxin PF06414.7 ESS67372.1 - 0.00071 18.7 0.0 0.02 14.0 0.0 2.2 1 1 0 1 1 1 1 Zeta toxin AAA_16 PF13191.1 ESS67372.1 - 0.00099 19.1 0.0 0.0025 17.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.1 ESS67372.1 - 0.0024 17.4 0.5 0.018 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS67372.1 - 0.0071 17.1 0.3 0.031 15.1 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_26 PF13500.1 ESS67372.1 - 0.012 15.2 0.2 2.5 7.6 0.0 2.9 2 1 1 3 3 3 0 AAA domain SRP54 PF00448.17 ESS67372.1 - 0.015 14.7 0.6 0.11 11.9 0.2 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Rad17 PF03215.10 ESS67372.1 - 0.03 13.0 0.0 0.044 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF258 PF03193.11 ESS67372.1 - 0.032 13.4 0.1 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Poly_export PF02563.11 ESS67372.1 - 0.06 13.1 0.2 0.29 10.9 0.0 2.2 3 0 0 3 3 3 0 Polysaccharide biosynthesis/export protein Sbi-IV PF11621.3 ESS67372.1 - 0.11 12.6 0.0 0.41 10.8 0.0 2.0 1 0 0 1 1 1 0 C3 binding domain 4 of IgG-bind protein SBI AAA_18 PF13238.1 ESS67372.1 - 0.13 12.5 0.2 0.25 11.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain NIF PF03031.13 ESS67373.1 - 3.5e-49 166.5 0.0 5.2e-49 165.9 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PseudoU_synth_2 PF00849.17 ESS67375.1 - 2.1e-25 89.4 0.2 4.8e-25 88.2 0.1 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase SNF2_N PF00176.18 ESS67376.1 - 1.6e-44 151.8 0.0 2.2e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS67376.1 - 1.3e-12 47.4 0.1 4.6e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PHD PF00628.24 ESS67376.1 - 1.1e-05 25.0 13.1 9.7e-05 21.9 1.1 2.9 3 0 0 3 3 3 2 PHD-finger C1_1 PF00130.17 ESS67376.1 - 0.001 18.7 1.3 0.001 18.7 0.9 2.8 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) ResIII PF04851.10 ESS67376.1 - 0.019 14.8 0.0 0.15 11.8 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit zf-PHD-like PF15446.1 ESS67376.1 - 0.12 11.6 7.9 0.094 12.0 0.2 2.6 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain IBR PF01485.16 ESS67376.1 - 9.2 6.2 17.3 0.099 12.5 4.9 2.4 1 1 1 2 2 2 0 IBR domain SpoIIE PF07228.7 ESS67377.1 - 1.2e-13 51.1 0.2 1.3e-12 47.7 0.1 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESS67377.1 - 1.4e-07 31.1 0.2 3.9e-07 29.6 0.1 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 ESS67377.1 - 0.00013 21.4 0.2 0.00073 19.0 0.0 2.1 3 0 0 3 3 3 1 Protein phosphatase 2C Rieske_2 PF13806.1 ESS67378.1 - 1e-08 34.7 0.0 2.5e-08 33.5 0.0 1.7 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.21 ESS67378.1 - 7.6e-08 31.8 0.6 2.7e-07 30.0 0.2 1.9 1 1 1 2 2 2 1 Rieske [2Fe-2S] domain FAD_binding_6 PF00970.19 ESS67378.1 - 2.6e-05 24.2 0.0 5.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESS67378.1 - 0.036 13.9 0.1 2.6 7.9 0.1 2.4 1 1 0 1 1 1 0 Ferric reductase NAD binding domain GTP_EFTU PF00009.22 ESS67379.1 - 4e-45 153.5 0.0 6.1e-45 152.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 ESS67379.1 - 4e-16 58.6 0.0 8.7e-16 57.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.13 ESS67379.1 - 1.5e-06 27.8 0.0 3.4e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 ESS67379.1 - 4.3e-05 23.2 0.0 0.00019 21.2 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESS67379.1 - 0.00095 19.2 0.0 0.0018 18.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 ESS67379.1 - 0.037 14.5 0.0 0.097 13.1 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein tRNA_bind PF01588.15 ESS67409.1 - 7.6e-26 89.7 0.1 3e-25 87.8 0.0 1.9 2 0 0 2 2 2 1 Putative tRNA binding domain Polyketide_cyc PF03364.15 ESS67410.1 - 2e-15 56.8 0.0 3.8e-15 56.0 0.0 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Adap_comp_sub PF00928.16 ESS67414.1 - 6.6e-14 51.6 0.0 1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESS67414.1 - 8.9e-06 25.4 0.3 1.4e-05 24.8 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF221 PF02714.10 ESS67415.1 - 2.2e-37 128.6 6.8 2.2e-37 128.6 4.7 1.9 2 0 0 2 2 2 1 Domain of unknown function DUF221 Pro_isomerase PF00160.16 ESS67416.1 - 1.8e-34 119.1 0.0 2.9e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD dsrm PF00035.20 ESS67418.1 - 2.2e-05 24.9 0.0 0.051 14.1 0.0 3.3 3 0 0 3 3 3 2 Double-stranded RNA binding motif Cullin PF00888.17 ESS67419.1 - 1e-39 136.6 0.0 3.6e-33 114.9 0.0 2.4 2 1 0 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.4 ESS67419.1 - 1.4e-20 72.9 0.6 2.9e-20 71.8 0.4 1.6 1 0 0 1 1 1 1 Cullin protein neddylation domain CDK2AP PF09806.4 ESS67420.1 - 0.12 12.6 2.9 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Bunya_NS-S_2 PF03231.8 ESS67420.1 - 0.65 8.5 0.1 0.99 7.9 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-S DUF563 PF04577.9 ESS67423.1 - 1e-06 28.7 0.0 1.9e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DAGK_acc PF00609.14 ESS67426.1 - 1e-25 90.7 0.0 3.7e-25 88.9 0.0 1.9 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 ESS67426.1 - 1.3e-10 40.7 0.0 2.6e-09 36.5 0.0 2.4 1 1 1 2 2 2 1 Diacylglycerol kinase catalytic domain Secretin_N_2 PF07655.8 ESS67427.1 - 9.9 6.6 12.4 5.2 7.5 2.1 2.9 2 0 0 2 2 2 0 Secretin N-terminal domain LRR_4 PF12799.2 ESS67429.1 - 5.6e-30 102.4 14.2 0.00015 21.2 0.0 11.9 6 3 10 16 16 16 13 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESS67429.1 - 9.4e-16 56.0 19.0 5.2 7.4 0.0 14.8 16 0 0 16 16 16 5 Leucine Rich repeat LRR_8 PF13855.1 ESS67429.1 - 1e-11 44.4 24.9 0.0082 15.8 0.3 8.8 6 3 3 9 9 9 6 Leucine rich repeat LRR_1 PF00560.28 ESS67429.1 - 0.0031 17.3 24.0 29 5.2 0.0 11.9 13 1 0 13 13 13 0 Leucine Rich Repeat LRR_7 PF13504.1 ESS67429.1 - 3 8.4 24.0 1.2e+02 3.6 0.0 10.9 11 1 0 11 11 11 0 Leucine rich repeat BLVR PF06375.6 ESS67429.1 - 10 5.9 14.9 0.42 10.4 1.7 3.0 3 0 0 3 3 3 0 Bovine leukaemia virus receptor (BLVR) RNA_pol_Rpb1_5 PF04998.12 ESS67432.1 - 8.4e-54 182.6 0.0 1.4e-53 181.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ESS67432.1 - 3e-48 163.9 0.0 7.6e-48 162.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 ESS67432.1 - 4.8e-32 110.8 0.0 8.6e-32 110.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESS67432.1 - 1.5e-16 60.0 0.0 6.8e-16 57.9 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RecR PF02132.10 ESS67432.1 - 0.019 14.3 0.1 0.049 13.0 0.0 1.7 1 0 0 1 1 1 0 RecR protein TLP-20 PF06088.6 ESS67432.1 - 6.1 6.4 15.8 0.15 11.6 3.3 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Amidase PF01425.16 ESS67433.1 - 2.2e-62 211.3 0.0 9.6e-62 209.2 0.0 1.8 1 1 0 1 1 1 1 Amidase OTU PF02338.14 ESS67434.1 - 3.9e-14 53.2 0.0 1e-13 51.9 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ESS67434.1 - 0.13 11.6 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase C65 Otubain EMG1 PF03587.9 ESS67435.1 - 1.5e-74 249.6 0.0 1.8e-74 249.4 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase IQ PF00612.22 ESS67436.1 - 0.019 14.5 0.3 0.058 13.0 0.2 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF4618 PF15397.1 ESS67436.1 - 3.4 6.9 30.3 0.49 9.6 17.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) AAA_11 PF13086.1 ESS67437.1 - 1.1 8.8 5.2 1.9 7.9 3.6 1.3 1 0 0 1 1 1 0 AAA domain SNARE PF05739.14 ESS67440.1 - 1.9e-05 24.2 5.2 0.013 15.2 1.2 2.2 2 0 0 2 2 2 2 SNARE domain DUF16 PF01519.11 ESS67440.1 - 0.35 11.1 2.9 5.2 7.3 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 Nup54 PF13874.1 ESS67440.1 - 0.71 9.5 4.0 0.72 9.5 0.7 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Filament PF00038.16 ESS67441.1 - 0.0047 16.4 34.0 0.061 12.7 11.0 2.2 1 1 1 2 2 2 2 Intermediate filament protein Apolipoprotein PF01442.13 ESS67441.1 - 0.005 16.3 8.3 0.005 16.3 5.8 2.5 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.5 ESS67441.1 - 0.0093 16.1 9.7 1.8 8.7 3.1 3.1 1 1 2 3 3 3 1 Fibrinogen alpha/beta chain family AAA_13 PF13166.1 ESS67441.1 - 0.019 13.4 11.1 0.032 12.7 7.7 1.4 1 1 0 1 1 1 0 AAA domain CENP-F_leu_zip PF10473.4 ESS67441.1 - 0.071 12.9 35.7 0.11 12.3 9.5 3.4 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GreA_GreB_N PF03449.10 ESS67441.1 - 0.086 12.9 25.8 1 9.4 1.0 4.8 3 1 1 4 4 4 0 Transcription elongation factor, N-terminal Baculo_PEP_C PF04513.7 ESS67441.1 - 0.088 12.6 7.6 1.3 8.8 0.5 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ERM PF00769.14 ESS67441.1 - 0.21 11.1 38.6 0.2 11.1 1.9 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Snapin_Pallidin PF14712.1 ESS67441.1 - 0.22 11.8 24.6 0.23 11.7 2.3 4.5 2 2 1 4 4 4 0 Snapin/Pallidin DUF1664 PF07889.7 ESS67441.1 - 0.24 11.2 10.9 2.6 7.8 1.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.15 ESS67441.1 - 0.38 10.5 24.2 6.8 6.4 0.3 4.0 2 1 0 2 2 2 0 Prefoldin subunit Atg14 PF10186.4 ESS67441.1 - 0.44 9.4 25.8 2.1 7.1 5.1 2.6 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Tweety PF04906.8 ESS67441.1 - 0.62 8.4 5.3 4.7 5.5 0.5 2.1 2 0 0 2 2 2 0 Tweety Bacillus_HBL PF05791.6 ESS67441.1 - 0.76 9.1 9.4 1.8 7.9 2.1 2.8 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Y_phosphatase3 PF13350.1 ESS67441.1 - 1 9.6 7.9 1.8 8.8 1.4 2.4 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF3584 PF12128.3 ESS67441.1 - 1.2 6.3 28.4 12 3.0 20.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) COG5 PF10392.4 ESS67441.1 - 1.4 8.9 10.9 0.96 9.4 2.5 2.9 2 1 1 3 3 3 0 Golgi transport complex subunit 5 GAS PF13851.1 ESS67441.1 - 1.4 8.0 28.1 0.31 10.2 12.6 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TBPIP PF07106.8 ESS67441.1 - 2.3 7.7 21.6 2.2 7.8 3.3 3.4 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc7 PF08317.6 ESS67441.1 - 2.9 6.4 25.3 2.1 6.9 4.2 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Phage_GP20 PF06810.6 ESS67441.1 - 3 7.2 20.4 10 5.5 1.2 4.1 2 1 2 4 4 4 0 Phage minor structural protein GP20 IncA PF04156.9 ESS67441.1 - 3.3 7.2 40.4 0.43 10.1 14.0 3.1 1 1 2 3 3 3 0 IncA protein TPR_MLP1_2 PF07926.7 ESS67441.1 - 3.7 7.3 31.2 8.1 6.1 14.9 3.1 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.14 ESS67441.1 - 4.5 4.9 18.3 1.6e+02 -0.2 12.7 2.9 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family MscS_porin PF12795.2 ESS67441.1 - 5.2 6.3 34.1 0.11 11.7 0.4 3.2 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain V-SNARE PF05008.10 ESS67441.1 - 8.2 6.6 23.9 0.076 13.1 5.3 3.7 3 1 1 4 4 3 0 Vesicle transport v-SNARE protein N-terminus Kinesin PF00225.18 ESS67442.1 - 9.3e-81 271.1 0.0 9.3e-81 271.1 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain AAA_13 PF13166.1 ESS67442.1 - 0.0052 15.3 26.8 0.009 14.5 18.5 1.4 1 0 0 1 1 1 1 AAA domain TBPIP PF07106.8 ESS67442.1 - 0.011 15.3 39.3 0.1 12.1 9.2 3.3 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3349 PF11829.3 ESS67442.1 - 0.18 12.2 2.7 5.5 7.4 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) Gp58 PF07902.6 ESS67442.1 - 0.36 8.9 13.9 5.7 5.0 9.6 2.0 1 1 0 1 1 1 0 gp58-like protein IncA PF04156.9 ESS67442.1 - 0.41 10.2 42.6 1.2 8.7 2.3 3.5 1 1 2 3 3 3 0 IncA protein Reo_sigmaC PF04582.7 ESS67442.1 - 0.63 9.1 11.7 2.2 7.3 4.7 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 ESS67442.1 - 0.99 9.1 40.5 4.6 6.9 6.7 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.2 ESS67442.1 - 3.7 7.4 50.3 6.1 6.6 15.8 3.1 1 1 2 3 3 3 0 Tropomyosin like TMF_DNA_bd PF12329.3 ESS67442.1 - 5.8 6.7 47.6 0.18 11.6 2.9 4.7 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF812 PF05667.6 ESS67442.1 - 9.4 4.5 33.5 23 3.3 23.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Myosin_TH1 PF06017.8 ESS67447.1 - 9.3e-19 67.5 0.0 2.9e-08 33.2 0.0 3.4 3 0 0 3 3 3 3 Myosin tail PH PF00169.24 ESS67447.1 - 0.17 12.1 0.8 75 3.5 0.0 4.2 4 1 0 4 4 4 0 PH domain Thymidylate_kin PF02223.12 ESS67448.1 - 0.028 13.8 0.3 0.13 11.6 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase ERO1 PF04137.10 ESS67449.1 - 6.4e-99 331.3 0.7 8.1e-99 331.0 0.5 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DNA_pol_B PF00136.16 ESS67450.1 - 7.8e-121 404.0 0.0 1.3e-120 403.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESS67450.1 - 1.1e-45 155.9 0.0 1.9e-45 155.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.5 ESS67450.1 - 0.0007 19.0 0.8 0.0067 15.7 1.1 2.1 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger WD40 PF00400.27 ESS67451.1 - 1.3e-16 59.7 6.2 0.012 15.4 0.1 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ELK PF03789.8 ESS67451.1 - 0.033 13.9 0.3 0.43 10.4 0.0 3.0 3 0 0 3 3 3 0 ELK domain Reo_sigmaC PF04582.7 ESS67451.1 - 0.059 12.5 6.5 0.32 10.1 0.2 3.4 2 2 1 3 3 3 0 Reovirus sigma C capsid protein DUF2404 PF10296.4 ESS67453.1 - 0.0019 18.2 0.0 0.005 16.9 0.0 1.7 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Kinesin PF00225.18 ESS67454.1 - 1.1e-79 267.6 0.4 1.7e-78 263.6 0.3 2.1 1 1 0 1 1 1 1 Kinesin motor domain Tropomyosin_1 PF12718.2 ESS67454.1 - 0.89 9.4 5.5 2 8.2 3.8 1.5 1 0 0 1 1 1 0 Tropomyosin like RRM_6 PF14259.1 ESS67455.1 - 2.1e-12 46.8 0.0 3.5e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS67455.1 - 6.4e-12 44.9 0.0 1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67455.1 - 2.3e-06 27.3 0.0 4.1e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.3 ESS67455.1 - 0.014 15.7 0.2 0.026 14.8 0.2 1.5 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Band_7 PF01145.20 ESS67456.1 - 6.1e-23 81.6 4.7 8.9e-23 81.1 3.2 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF4200 PF13863.1 ESS67456.1 - 0.0047 16.8 2.4 0.0047 16.8 1.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) WD40 PF00400.27 ESS67457.1 - 7.8e-07 28.7 5.3 0.014 15.2 0.0 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Nop PF01798.13 ESS67458.1 - 9e-11 41.2 0.3 1.6e-10 40.4 0.2 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 ESS67458.1 - 0.00099 19.5 2.7 0.0016 18.8 1.9 1.4 1 0 0 1 1 1 1 Prp31 C terminal domain DUF99 PF01949.11 ESS67458.1 - 0.048 12.7 0.0 0.15 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF99 Apelin PF15360.1 ESS67458.1 - 1.1 9.5 6.8 2.8 8.2 1.0 2.5 2 0 0 2 2 2 0 APJ endogenous ligand eIF3_p135 PF12807.2 ESS67459.1 - 4.7e-06 26.6 0.1 1.1e-05 25.3 0.0 1.6 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.1 ESS67459.1 - 0.06 13.2 0.6 2.4 8.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS67460.1 - 3.8e-05 23.5 1.5 0.018 14.9 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat MIF4G PF02854.14 ESS67461.1 - 2e-31 109.0 3.3 3.5e-31 108.2 2.3 1.4 1 0 0 1 1 1 1 MIF4G domain THAP PF05485.7 ESS67461.1 - 0.021 14.9 0.8 0.055 13.6 0.5 1.7 1 0 0 1 1 1 0 THAP domain RVT_1 PF00078.22 ESS67487.1 - 2.2e-16 59.8 0.0 3.1e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Vac_Fusion PF02346.11 ESS67488.1 - 0.065 12.6 5.8 0.054 12.9 0.8 2.3 2 0 0 2 2 2 0 Chordopoxvirus fusion protein ApoO PF09769.4 ESS67488.1 - 0.078 12.6 0.2 0.13 11.9 0.2 1.3 1 0 0 1 1 1 0 Apolipoprotein O Reo_sigmaC PF04582.7 ESS67488.1 - 2 7.5 5.1 1.1 8.3 1.6 1.7 1 1 1 2 2 2 0 Reovirus sigma C capsid protein AATF-Che1 PF13339.1 ESS67488.1 - 2.1 8.5 7.9 2.2 8.4 3.5 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Rho_Binding PF08912.6 ESS67488.1 - 9.2 6.6 11.0 6 7.2 0.8 2.6 2 0 0 2 2 2 0 Rho Binding WD40 PF00400.27 ESS67489.1 - 0.0025 17.6 0.1 1.7 8.6 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF2415 PF10313.4 ESS67489.1 - 0.1 12.2 0.0 0.62 9.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) PEX11 PF05648.9 ESS67490.1 - 5e-15 55.3 2.0 6.5e-13 48.4 1.4 2.9 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PIG-L PF02585.12 ESS67491.1 - 6.2e-24 84.9 0.1 8.7e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF1656 PF07869.7 ESS67491.1 - 0.25 11.1 7.6 2.9 7.7 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) HhH-GPD PF00730.20 ESS67492.1 - 1.9e-18 66.7 0.0 2.7e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 ESS67492.1 - 4.6e-08 32.3 0.0 1.2e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.1 ESS67492.1 - 0.0013 18.8 0.1 0.16 12.1 0.0 1.9 1 1 1 2 2 2 2 Helix-hairpin-helix domain EndIII_4Fe-2S PF10576.4 ESS67492.1 - 0.0059 16.7 9.2 0.012 15.7 6.4 1.5 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HA2 PF04408.18 ESS67493.1 - 3.9e-19 68.5 0.0 7.3e-18 64.4 0.0 2.7 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESS67493.1 - 8.5e-15 54.5 0.0 2.2e-14 53.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RWD PF05773.17 ESS67493.1 - 3.2e-12 46.3 0.0 8.9e-12 44.9 0.0 1.8 1 0 0 1 1 1 1 RWD domain Helicase_C PF00271.26 ESS67493.1 - 1.3e-10 40.9 0.1 3.3e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS67493.1 - 4.3e-09 36.0 0.1 1.4e-08 34.3 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS67493.1 - 3.3e-05 24.0 2.6 0.0005 20.2 0.0 3.2 3 1 1 4 4 4 1 AAA domain zf-CCHC PF00098.18 ESS67493.1 - 0.00073 19.3 1.0 0.00073 19.3 0.7 2.4 2 0 0 2 2 2 1 Zinc knuckle T2SE PF00437.15 ESS67493.1 - 0.001 18.0 0.0 0.0023 16.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.1 ESS67493.1 - 0.087 13.1 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 ESS67493.1 - 0.093 12.5 0.0 21 4.8 0.0 2.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit RRM_1 PF00076.17 ESS67494.1 - 4.4e-18 64.6 0.0 5.9e-18 64.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67494.1 - 1.7e-12 47.1 0.0 2.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67494.1 - 9.6e-10 38.1 0.0 1.4e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pyocin_S PF06958.7 ESS67494.1 - 0.72 10.2 6.4 0.1 12.9 1.3 1.7 1 1 1 2 2 2 0 S-type Pyocin EF-hand_7 PF13499.1 ESS67496.1 - 1e-10 41.5 2.3 2.7e-10 40.2 0.4 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESS67496.1 - 9.3e-08 30.8 0.4 1.7e-05 23.7 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 ESS67496.1 - 1e-06 28.2 1.0 2e-05 24.0 0.5 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 ESS67496.1 - 2.7e-06 26.4 0.7 6.8e-06 25.1 0.5 1.7 1 0 0 1 1 1 1 EF hand EF-hand_10 PF14788.1 ESS67496.1 - 0.00068 19.2 0.2 0.0019 17.8 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 ESS67496.1 - 0.0011 18.6 1.3 0.024 14.5 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain Tropomyosin PF00261.15 ESS67496.1 - 0.054 12.5 69.3 0.92 8.5 36.0 3.5 1 1 1 2 2 2 0 Tropomyosin DUF3584 PF12128.3 ESS67496.1 - 0.13 9.5 67.9 0.084 10.1 25.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF745 PF05335.8 ESS67496.1 - 8.2 5.9 47.4 0.64 9.5 12.0 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF745) CTP_transf_3 PF02348.14 ESS67497.1 - 0.05 13.2 0.1 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase L_lactis_ph-MCP PF06673.6 ESS67498.1 - 0.28 9.9 2.1 0.55 8.9 1.4 1.5 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein Kinesin PF00225.18 ESS67499.1 - 2.3e-79 266.5 8.8 1.4e-48 165.2 0.1 2.9 2 1 1 3 3 3 2 Kinesin motor domain AAA_22 PF13401.1 ESS67499.1 - 0.096 12.8 1.1 0.35 11.0 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.12 ESS67499.1 - 1.2 8.9 8.8 0.35 10.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 Cluap1 PF10234.4 ESS67499.1 - 5.9 6.0 22.3 0.17 11.0 8.1 2.8 3 0 0 3 3 3 0 Clusterin-associated protein-1 Spc7 PF08317.6 ESS67500.1 - 3.5e-05 22.6 26.2 0.0022 16.7 6.7 2.1 2 0 0 2 2 2 2 Spc7 kinetochore protein Bacillus_HBL PF05791.6 ESS67500.1 - 0.0018 17.6 4.4 0.0018 17.6 3.0 3.0 2 1 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) TMF_DNA_bd PF12329.3 ESS67500.1 - 0.0026 17.5 7.4 0.0026 17.5 5.2 4.2 3 2 0 3 3 3 1 TATA element modulatory factor 1 DNA binding ERM PF00769.14 ESS67500.1 - 0.0031 17.0 20.0 0.0031 17.0 13.9 2.6 1 1 2 3 3 2 1 Ezrin/radixin/moesin family TMF_TATA_bd PF12325.3 ESS67500.1 - 0.0038 16.9 1.9 0.0038 16.9 1.3 4.1 1 1 4 5 5 5 1 TATA element modulatory factor 1 TATA binding HTH_Tnp_Tc3_1 PF11427.3 ESS67500.1 - 0.0046 16.5 0.1 0.014 15.0 0.0 1.8 1 0 0 1 1 1 1 Tc3 transposase DUF4407 PF14362.1 ESS67500.1 - 0.0051 15.8 21.1 0.1 11.5 9.5 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) CCDC-167 PF15188.1 ESS67500.1 - 0.007 16.2 5.5 0.007 16.2 3.8 4.3 2 2 3 5 5 5 1 Coiled-coil domain-containing protein 167 DUF641 PF04859.7 ESS67500.1 - 0.015 15.0 7.8 0.015 15.0 5.4 3.1 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Fib_alpha PF08702.5 ESS67500.1 - 0.055 13.6 21.3 0.23 11.5 2.7 2.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Reo_sigmaC PF04582.7 ESS67500.1 - 0.55 9.3 7.0 4.3 6.4 0.7 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Prefoldin PF02996.12 ESS67500.1 - 1.2 8.7 18.1 9.4 5.9 0.0 4.2 3 2 1 4 4 4 0 Prefoldin subunit DUF3138 PF11336.3 ESS67500.1 - 2 6.5 5.1 1.8 6.6 2.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) FH2 PF02181.18 ESS67500.1 - 2.5 6.9 17.1 0.62 8.8 0.4 3.0 1 1 2 3 3 3 0 Formin Homology 2 Domain Tropomyosin_1 PF12718.2 ESS67500.1 - 2.8 7.8 29.9 11 5.8 8.9 3.3 1 1 1 2 2 2 0 Tropomyosin like MutS_IV PF05190.13 ESS67500.1 - 5.5 7.2 11.5 8.7 6.5 0.2 3.7 2 1 2 4 4 4 0 MutS family domain IV APG6 PF04111.7 ESS67500.1 - 5.8 5.8 32.2 7.9 5.4 9.0 2.6 1 1 2 3 3 3 0 Autophagy protein Apg6 DUF4226 PF10774.4 ESS67500.1 - 6.3 6.8 10.0 0.86 9.6 2.6 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4226) Cep57_CLD PF14073.1 ESS67500.1 - 6.6 6.5 32.2 0.37 10.5 9.4 2.3 1 1 0 2 2 2 0 Centrosome localisation domain of Cep57 Atg14 PF10186.4 ESS67500.1 - 8.3 5.2 29.6 0.79 8.6 5.9 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 PEHE PF15275.1 ESS67500.1 - 8.6 6.8 10.2 0.58 10.6 2.9 2.0 2 1 0 2 2 2 0 PEHE domain FlaC_arch PF05377.6 ESS67500.1 - 8.6 6.3 14.9 0.39 10.6 0.4 4.0 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) CDC37_N PF03234.9 ESS67500.1 - 9.5 6.5 20.1 3.7 7.8 8.8 2.3 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding FHA PF00498.21 ESS67501.1 - 6.5e-14 51.8 0.0 2.4e-13 50.0 0.0 1.9 2 0 0 2 2 2 1 FHA domain zf-C3HC4 PF00097.20 ESS67501.1 - 5.9e-06 25.8 11.0 5.9e-06 25.8 7.6 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS67501.1 - 0.00029 20.7 16.8 0.00029 20.7 11.7 4.4 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS67501.1 - 0.0024 17.7 12.4 0.0024 17.7 8.6 4.4 4 2 1 5 5 5 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 ESS67501.1 - 0.0031 17.3 14.7 0.0031 17.3 10.2 4.2 3 1 1 4 4 4 1 Ring finger domain DUF4501 PF14946.1 ESS67501.1 - 0.28 10.6 8.5 0.043 13.2 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) SLY PF12485.3 ESS67501.1 - 1.2 9.3 6.4 0.12 12.5 0.3 2.0 2 0 0 2 2 2 0 Lymphocyte signaling adaptor protein NRDE PF05742.7 ESS67502.1 - 4.5e-20 72.0 0.1 8e-14 51.5 0.0 3.4 3 1 0 3 3 3 3 NRDE protein DUF4586 PF15239.1 ESS67503.1 - 8.8e-34 117.4 3.8 1.1e-33 117.0 2.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) VTC PF09359.5 ESS67504.1 - 4.3e-77 258.9 0.0 6.2e-77 258.4 0.0 1.2 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.10 ESS67504.1 - 0.00079 19.5 2.5 0.00079 19.5 1.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF2910 PF11139.3 ESS67504.1 - 0.0074 15.4 1.0 0.012 14.7 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2910) Ferric_reduct PF01794.14 ESS67504.1 - 0.093 12.8 2.5 0.2 11.7 1.8 1.5 1 0 0 1 1 1 0 Ferric reductase like transmembrane component Cytochrom_B_N PF00033.14 ESS67504.1 - 0.15 11.3 3.7 0.27 10.5 2.6 1.3 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB AAA_2 PF07724.9 ESS67505.1 - 5.8e-39 133.7 2.0 5.5e-31 107.7 0.2 2.7 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESS67505.1 - 3.5e-12 46.6 2.3 4.2e-05 23.7 0.1 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 ESS67505.1 - 3.5e-07 30.0 1.9 5.9e-07 29.2 0.2 2.2 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 ESS67505.1 - 9.2e-07 28.6 0.8 3.4e-05 23.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) MCM PF00493.18 ESS67505.1 - 3e-06 26.2 0.3 0.00042 19.2 0.0 2.3 2 0 0 2 2 2 1 MCM2/3/5 family AAA_17 PF13207.1 ESS67505.1 - 5.8e-06 27.1 1.4 7.5e-05 23.5 0.1 3.0 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESS67505.1 - 0.0001 22.6 1.3 0.0018 18.5 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.1 ESS67505.1 - 0.00012 22.2 0.0 0.0092 16.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESS67505.1 - 0.00077 18.6 0.3 0.0022 17.1 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 ESS67505.1 - 0.00089 19.2 0.1 0.072 13.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.21 ESS67505.1 - 0.0016 17.9 0.1 0.07 12.5 0.0 3.2 3 1 1 4 4 4 1 Sigma-54 interaction domain AAA_14 PF13173.1 ESS67505.1 - 0.0026 17.6 0.1 3.3 7.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 ESS67505.1 - 0.0058 16.5 0.0 0.073 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESS67505.1 - 0.016 14.2 0.6 0.42 9.6 0.0 2.7 3 0 0 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 ESS67505.1 - 0.018 14.2 0.1 0.083 12.0 0.0 2.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.20 ESS67505.1 - 0.02 14.4 0.0 0.048 13.1 0.0 1.6 2 0 0 2 2 1 0 ATP synthase alpha/beta family, nucleotide-binding domain IPT PF01745.11 ESS67505.1 - 0.038 13.1 0.0 0.069 12.3 0.0 1.5 1 0 0 1 1 1 0 Isopentenyl transferase CPT PF07931.7 ESS67505.1 - 0.042 13.4 0.0 0.12 11.9 0.0 1.7 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein IstB_IS21 PF01695.12 ESS67505.1 - 0.044 13.2 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.10 ESS67505.1 - 0.05 13.4 0.0 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MobB PF03205.9 ESS67505.1 - 0.055 13.1 0.0 0.32 10.7 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 ESS67505.1 - 0.067 13.3 0.8 1.6 8.9 0.0 2.7 3 0 0 3 3 2 0 RNA helicase UCH PF00443.24 ESS67506.1 - 1.8e-40 138.7 0.0 7.3e-40 136.7 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS67506.1 - 1.3e-08 34.6 0.0 8.9e-08 31.9 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CPSF73-100_C PF11718.3 ESS67507.1 - 0.0027 17.0 5.8 0.0031 16.8 4.0 1.1 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term MH2 PF03166.9 ESS67507.1 - 0.017 14.9 1.2 0.032 14.0 0.1 1.7 1 1 1 2 2 2 0 MH2 domain DUF1754 PF08555.5 ESS67507.1 - 0.086 13.4 9.3 0.11 13.0 6.5 1.1 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Rxt3 PF08642.5 ESS67507.1 - 0.12 12.6 7.0 0.41 10.9 0.1 2.0 1 1 1 2 2 2 0 Histone deacetylation protein Rxt3 Suf PF05843.9 ESS67507.1 - 0.22 11.1 7.0 0.23 11.1 4.8 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hom_end_hint PF05203.11 ESS67507.1 - 0.5 10.0 5.9 0.52 10.0 4.1 1.1 1 0 0 1 1 1 0 Hom_end-associated Hint DUF3452 PF11934.3 ESS67507.1 - 0.65 9.3 5.1 0.91 8.8 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) DUF4638 PF15472.1 ESS67507.1 - 1.8 8.0 8.5 2.2 7.8 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Pex16 PF08610.5 ESS67507.1 - 2.1 7.2 6.2 2.4 7.0 4.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Zip PF02535.17 ESS67507.1 - 6.5 5.6 5.4 7.3 5.4 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MCM PF00493.18 ESS67508.1 - 2.7e-124 414.3 0.0 3.4e-124 413.9 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESS67508.1 - 1.1e-17 64.6 0.0 6.5e-17 62.1 0.0 2.2 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.9 ESS67508.1 - 1.7e-09 37.5 0.0 4.5e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS67508.1 - 7e-08 31.8 0.0 9.3e-06 24.9 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESS67508.1 - 0.00067 19.2 0.0 0.0016 18.0 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESS67508.1 - 0.025 14.2 0.0 6.4 6.4 0.0 2.5 1 1 1 2 2 2 0 NTPase Sigma54_activat PF00158.21 ESS67508.1 - 0.029 13.8 0.1 0.9 8.9 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain zf-BED PF02892.10 ESS67508.1 - 0.11 12.2 1.4 0.78 9.5 0.2 2.3 2 0 0 2 2 2 0 BED zinc finger DLIC PF05783.6 ESS67509.1 - 3.5e-05 22.6 1.4 4.2e-05 22.3 0.2 1.6 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) DUF4596 PF15363.1 ESS67509.1 - 1.4 8.9 8.0 0.15 11.9 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) MFS_1 PF07690.11 ESS67510.1 - 7.8e-27 93.8 37.3 4.9e-14 51.8 3.8 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 ESS67510.1 - 0.00081 17.9 16.6 0.024 13.1 1.3 3.2 2 1 1 3 3 3 2 Vacuole effluxer Atg22 like DUF2249 PF10006.4 ESS67510.1 - 0.0014 18.1 0.0 0.0032 17.0 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2249) UNC-93 PF05978.11 ESS67510.1 - 1.8 8.0 13.2 0.25 10.8 0.5 2.8 2 1 1 3 3 3 0 Ion channel regulatory protein UNC-93 Herpes_gE PF02480.11 ESS67511.1 - 0.0012 17.2 0.6 0.0012 17.2 0.4 1.0 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E DUF912 PF06024.7 ESS67511.1 - 0.0041 17.1 0.2 0.0047 16.9 0.1 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3808 PF10300.4 ESS67512.1 - 0.009 14.6 0.0 0.018 13.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) Voldacs PF03517.8 ESS67512.1 - 1.9 8.3 6.1 1.8 8.3 0.2 2.8 3 0 0 3 3 3 0 Regulator of volume decrease after cellular swelling TPR_16 PF13432.1 ESS67512.1 - 5.9 7.6 7.2 0.77 10.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RAB3GAP2_N PF14655.1 ESS67513.1 - 0.064 12.2 0.9 0.095 11.6 0.6 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Kinesin PF00225.18 ESS67514.1 - 1.7e-45 155.1 0.0 1.8e-20 72.9 0.0 3.3 3 0 0 3 3 3 3 Kinesin motor domain PLDc PF00614.17 ESS67515.1 - 0.0095 15.7 0.1 0.025 14.3 0.1 1.7 1 0 0 1 1 1 1 Phospholipase D Active site motif Pkinase PF00069.20 ESS67516.1 - 1.3e-45 155.6 0.0 3.9e-45 154.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67516.1 - 1.1e-17 63.9 0.0 2.8e-15 56.0 0.0 3.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS67516.1 - 3.4e-07 29.5 0.0 5.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS67516.1 - 0.001 18.8 0.1 0.001 18.8 0.0 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS67516.1 - 0.08 12.2 0.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.9 ESS67516.1 - 0.084 11.9 0.0 0.18 10.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CHASE PF03924.8 ESS67517.1 - 0.0006 19.1 0.0 0.002 17.3 0.0 1.9 2 0 0 2 2 2 1 CHASE domain zf-RING_2 PF13639.1 ESS67519.1 - 2e-09 37.1 10.3 2.2e-08 33.7 5.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 ESS67519.1 - 1.5e-08 34.6 6.7 3.5e-08 33.4 4.7 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESS67519.1 - 2.2e-05 24.2 1.5 5.3e-05 22.9 1.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 ESS67519.1 - 0.0013 18.7 4.5 0.0013 18.7 3.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS67519.1 - 0.008 15.8 6.1 0.0081 15.8 2.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS67519.1 - 0.0092 15.6 7.4 0.035 13.7 5.1 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS67519.1 - 0.029 14.0 3.7 0.029 14.0 2.6 2.0 2 0 0 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.3 ESS67519.1 - 0.079 12.9 6.2 4.7 7.2 3.3 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.1 ESS67519.1 - 0.085 12.4 2.3 0.2 11.2 1.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.6 ESS67519.1 - 1.2 9.1 5.3 2.9 7.9 3.6 1.6 1 0 0 1 1 1 0 RING-like domain FAD_binding_7 PF03441.9 ESS67520.1 - 2.5e-41 141.7 0.1 4.2e-41 141.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 ESS67520.1 - 1.9e-21 76.5 0.0 4.1e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase Plus-3 PF03126.13 ESS67521.1 - 0.0076 16.2 0.0 0.52 10.3 0.0 3.2 4 1 0 4 4 4 1 Plus-3 domain Spt20 PF12090.3 ESS67522.1 - 0.0028 17.0 0.1 0.0036 16.6 0.1 1.3 1 0 0 1 1 1 1 Spt20 family Mucin PF01456.12 ESS67522.1 - 0.0046 16.7 17.8 0.0051 16.5 10.6 2.4 1 1 1 2 2 2 1 Mucin-like glycoprotein TFIIA PF03153.8 ESS67522.1 - 0.0068 16.3 5.5 0.01 15.7 3.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Telomere_reg-2 PF10193.4 ESS67525.1 - 0.077 13.2 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 Telomere length regulation protein Bclt PF15318.1 ESS67526.1 - 0.0097 15.9 0.1 0.012 15.6 0.0 1.1 1 0 0 1 1 1 1 Putative Bcl-2 like protein of testis Pap_E4 PF02711.9 ESS67526.1 - 2.9 8.7 10.2 3.5 8.5 7.1 1.1 1 0 0 1 1 1 0 E4 protein Mucin PF01456.12 ESS67526.1 - 3.7 7.3 23.9 4.9 6.9 16.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.7 ESS67526.1 - 5.9 4.5 9.4 6.7 4.3 6.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pkinase PF00069.20 ESS67527.1 - 4.7e-49 166.8 0.0 6.8e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67527.1 - 1e-16 60.7 0.0 1.7e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS67527.1 - 0.0024 17.6 0.5 0.29 10.8 0.0 2.3 1 1 0 2 2 2 2 Phosphotransferase enzyme family Auxin_inducible PF02519.9 ESS67527.1 - 0.13 12.3 1.0 3 7.9 0.7 2.4 1 1 0 1 1 1 0 Auxin responsive protein DSPn PF14671.1 ESS67528.1 - 5.2e-24 84.8 0.0 1.7e-16 60.5 0.0 3.5 4 0 0 4 4 4 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 ESS67528.1 - 5.4e-10 38.9 0.1 1.7e-09 37.3 0.1 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESS67528.1 - 0.00015 21.7 0.0 0.0024 17.9 0.0 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 ESS67528.1 - 0.0016 17.8 0.1 0.0029 16.9 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF4390 PF14334.1 ESS67528.1 - 0.023 13.8 0.0 0.044 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4390) zf-C3HC4_3 PF13920.1 ESS67529.1 - 2e-10 40.1 10.8 3.5e-10 39.4 7.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Plus-3 PF03126.13 ESS67529.1 - 2.2e-08 34.0 0.0 4.6e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Plus-3 domain zf-C3HC4_2 PF13923.1 ESS67529.1 - 0.0059 16.6 13.2 0.011 15.7 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS67529.1 - 0.069 12.9 12.8 0.14 11.9 8.9 1.6 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 ESS67529.1 - 0.61 9.8 10.2 1 9.1 7.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain TPR_11 PF13414.1 ESS67531.1 - 1.2e-34 117.7 14.1 2.5e-07 30.2 0.0 5.9 4 1 2 6 6 6 6 TPR repeat TPR_2 PF07719.12 ESS67531.1 - 1.3e-27 93.4 15.2 0.00021 20.9 0.5 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESS67531.1 - 2.7e-24 83.6 16.3 4.2e-05 22.9 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESS67531.1 - 3.2e-21 75.0 22.8 2.8e-06 27.1 0.0 7.1 4 2 5 9 9 9 7 Tetratricopeptide repeat TPR_16 PF13432.1 ESS67531.1 - 2.8e-20 72.4 12.7 0.00092 19.8 0.0 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.1 ESS67531.1 - 1.8e-18 65.3 19.7 0.00063 20.1 0.1 9.2 2 1 8 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.1 ESS67531.1 - 1.2e-17 63.9 14.4 9.6e-06 25.8 0.4 5.3 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESS67531.1 - 5.2e-17 60.2 3.6 0.033 13.9 0.0 6.7 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESS67531.1 - 1e-15 56.5 11.3 0.00025 20.9 0.1 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS67531.1 - 3.3e-13 48.3 11.2 0.012 15.3 0.3 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat Apc3 PF12895.2 ESS67531.1 - 8.7e-12 45.0 10.6 0.012 15.6 2.1 5.6 2 1 5 7 7 7 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESS67531.1 - 1.1e-11 44.3 13.6 3.1e-07 30.1 0.4 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESS67531.1 - 3.8e-11 42.5 18.0 0.012 15.5 0.1 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESS67531.1 - 1.2e-10 41.0 17.3 0.0071 16.7 0.1 7.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.1 ESS67531.1 - 5.4e-06 25.6 9.3 4e-05 22.8 0.9 3.7 1 1 4 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS67531.1 - 9.4e-05 22.2 3.1 0.31 10.9 0.2 4.2 3 1 1 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 ESS67531.1 - 0.00018 21.5 7.0 0.81 9.8 0.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat Coatomer_E PF04733.9 ESS67531.1 - 0.0041 16.3 4.3 0.021 14.0 1.8 3.2 1 1 1 2 2 2 1 Coatomer epsilon subunit PPR PF01535.15 ESS67531.1 - 0.0064 16.3 5.3 4.3 7.5 0.0 4.8 5 0 0 5 5 4 1 PPR repeat ChAPs PF09295.5 ESS67531.1 - 0.017 13.8 4.2 0.15 10.7 0.6 2.9 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Apc5 PF12862.2 ESS67531.1 - 0.076 12.8 2.2 2.7 7.8 0.0 3.4 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 5 NARP1 PF12569.3 ESS67531.1 - 0.079 11.6 4.3 2.5 6.7 0.6 2.7 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 NRDE-2 PF08424.5 ESS67531.1 - 0.1 11.4 1.4 0.13 11.0 0.2 1.7 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference TPR_4 PF07721.9 ESS67531.1 - 0.12 12.8 0.7 26 5.6 0.0 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat EF-hand_5 PF13202.1 ESS67531.1 - 0.17 11.3 0.7 0.33 10.3 0.5 1.5 1 0 0 1 1 1 0 EF hand LURAP PF14854.1 ESS67532.1 - 0.022 14.4 2.6 0.32 10.7 0.1 3.0 2 0 0 2 2 2 0 Leucine rich adaptor protein DUF1981 PF09324.5 ESS67533.1 - 0.0027 17.1 0.1 0.047 13.2 0.0 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) YqzE PF14038.1 ESS67533.1 - 0.24 11.1 0.1 3.6 7.4 0.0 2.8 2 0 0 2 2 2 0 YqzE-like protein Sec62 PF03839.11 ESS67537.1 - 0.015 14.7 3.9 0.021 14.2 2.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 LRR_4 PF12799.2 ESS67539.1 - 0.0024 17.4 3.1 6.9 6.4 0.9 4.4 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS67539.1 - 0.0027 17.4 3.0 1.3 8.7 0.0 3.7 3 1 1 4 4 4 3 Leucine rich repeat Ycf1 PF05758.7 ESS67539.1 - 0.0048 14.7 0.1 0.0048 14.7 0.0 1.5 2 0 0 2 2 2 1 Ycf1 LRR_6 PF13516.1 ESS67539.1 - 0.09 12.8 2.8 3.7 7.9 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat DUF972 PF06156.8 ESS67539.1 - 1.2 9.5 14.9 0.048 14.0 0.6 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Tim54 PF11711.3 ESS67539.1 - 4.4 5.7 14.6 0.011 14.3 2.0 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 APG6 PF04111.7 ESS67539.1 - 6.4 5.7 17.1 3.4 6.6 0.1 2.5 2 0 0 2 2 2 0 Autophagy protein Apg6 RR_TM4-6 PF06459.7 ESS67539.1 - 8.6 6.1 25.0 0.22 11.3 8.0 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 GEMIN8 PF15348.1 ESS67540.1 - 7.2 6.5 9.4 0.44 10.5 1.6 2.1 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 UvrD-helicase PF00580.16 ESS67543.1 - 1.3e-23 83.8 0.0 2.6e-22 79.5 0.0 2.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 ESS67543.1 - 2.2e-12 47.1 0.0 6.8e-12 45.5 0.0 1.9 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 ESS67543.1 - 0.00049 20.2 0.0 0.26 11.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain PhoH PF02562.11 ESS67543.1 - 0.038 13.2 0.0 0.077 12.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Gemini_AL1 PF00799.15 ESS67543.1 - 0.047 13.5 0.4 0.12 12.2 0.3 1.6 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain Peptidase_S51 PF03575.12 ESS67544.1 - 2e-21 76.3 0.0 7.7e-15 54.9 0.0 2.1 2 0 0 2 2 2 2 Peptidase family S51 FimP PF09766.4 ESS67544.1 - 0.048 12.7 0.3 0.066 12.2 0.2 1.1 1 0 0 1 1 1 0 Fms-interacting protein Paramyx_P_V_C PF03210.8 ESS67544.1 - 0.072 12.9 0.0 0.13 12.1 0.0 1.5 1 1 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal PRKCSH-like PF12999.2 ESS67545.1 - 9.1e-11 41.6 7.7 1.6e-07 31.0 0.1 2.6 3 0 0 3 3 3 2 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 ESS67545.1 - 0.068 13.0 7.3 0.24 11.3 0.2 2.6 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A PH PF00169.24 ESS67547.1 - 2e-11 44.0 0.0 4.7e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 PH domain RRF PF01765.14 ESS67547.1 - 0.035 13.5 0.1 0.1 12.0 0.1 1.7 2 0 0 2 2 2 0 Ribosome recycling factor PRNT PF15174.1 ESS67547.1 - 0.054 13.1 0.1 0.18 11.4 0.1 1.9 1 0 0 1 1 1 0 Prion-related protein testis-specific zf-DHHC PF01529.15 ESS67548.1 - 1.1e-25 90.0 7.9 1.1e-25 90.0 5.5 3.2 3 1 0 3 3 3 2 DHHC palmitoyltransferase Voltage_CLC PF00654.15 ESS67548.1 - 0.0045 16.0 3.7 0.0045 16.0 2.6 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel Form-deh_trans PF09163.6 ESS67548.1 - 0.12 11.8 0.3 0.26 10.8 0.2 1.5 1 0 0 1 1 1 0 Formate dehydrogenase N, transmembrane KOG2701 PF09762.4 ESS67549.1 - 2e-56 190.9 10.4 3.4e-56 190.1 0.0 3.4 3 1 0 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) DUF3802 PF12290.3 ESS67549.1 - 0.014 15.6 0.5 0.094 13.0 0.1 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3802) AAA_33 PF13671.1 ESS67550.1 - 8.5e-05 22.4 0.2 0.00094 19.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS67550.1 - 0.01 16.6 0.0 0.029 15.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS67550.1 - 0.068 13.1 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 ESS67550.1 - 0.08 12.0 0.0 0.15 11.1 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin APS_kinase PF01583.15 ESS67550.1 - 0.081 12.5 0.1 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.1 ESS67550.1 - 0.17 12.2 1.1 0.47 10.7 0.7 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS67550.1 - 0.17 12.1 0.1 0.43 10.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter TYW3 PF02676.9 ESS67551.1 - 2e-40 138.1 0.0 3.9e-40 137.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase TYW3 Ion_trans PF00520.26 ESS67555.1 - 0.83 8.8 4.6 1.2 8.3 3.2 1.1 1 0 0 1 1 1 0 Ion transport protein Prefoldin_2 PF01920.15 ESS67556.1 - 3.2e-19 68.6 1.3 3.8e-19 68.4 0.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit DASH_Dad3 PF08656.5 ESS67556.1 - 0.0044 16.6 3.5 0.031 13.9 0.4 2.1 2 0 0 2 2 2 1 DASH complex subunit Dad3 ALIX_LYPXL_bnd PF13949.1 ESS67556.1 - 0.015 14.2 2.1 0.24 10.3 0.0 2.0 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV SlyX PF04102.7 ESS67556.1 - 0.027 14.8 2.7 0.097 13.0 0.1 2.2 2 0 0 2 2 2 0 SlyX Seryl_tRNA_N PF02403.17 ESS67556.1 - 0.027 14.4 1.2 0.048 13.6 0.8 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.9 ESS67556.1 - 0.033 13.7 7.2 0.25 10.8 1.6 2.0 1 1 1 2 2 2 0 IncA protein DivIVA PF05103.8 ESS67556.1 - 0.041 13.9 2.4 0.87 9.6 0.1 2.1 2 0 0 2 2 2 0 DivIVA protein Syntaxin_2 PF14523.1 ESS67556.1 - 0.048 13.6 0.9 1.7 8.7 0.1 2.1 2 0 0 2 2 2 0 Syntaxin-like protein Med9 PF07544.8 ESS67556.1 - 0.056 13.1 2.7 0.056 13.1 0.2 2.0 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 CK2S PF15011.1 ESS67556.1 - 0.058 13.1 2.1 0.12 12.1 1.4 1.5 1 1 0 1 1 1 0 Casein Kinase 2 substrate Microtub_bind PF13931.1 ESS67556.1 - 0.058 13.5 0.6 0.35 11.0 0.1 1.9 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding Atg14 PF10186.4 ESS67556.1 - 0.066 12.1 1.3 0.081 11.8 0.9 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Nup54 PF13874.1 ESS67556.1 - 0.068 12.8 2.4 2.1 8.0 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Prefoldin PF02996.12 ESS67556.1 - 0.074 12.7 1.0 0.49 10.0 0.0 2.0 2 0 0 2 2 2 0 Prefoldin subunit AKNA PF12443.3 ESS67556.1 - 0.11 12.4 0.7 0.5 10.4 0.0 2.0 2 0 0 2 2 2 0 AT-hook-containing transcription factor RUN PF02759.14 ESS67556.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 1 0 1 1 1 0 RUN domain FUSC PF04632.7 ESS67556.1 - 0.19 10.1 0.3 0.2 10.0 0.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FTA4 PF13093.1 ESS67556.1 - 0.19 11.1 3.4 0.39 10.1 1.1 1.9 1 1 1 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF3847 PF12958.2 ESS67556.1 - 0.63 9.8 3.6 0.89 9.3 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) FliJ PF02050.11 ESS67556.1 - 0.86 9.6 7.1 3.4 7.7 1.0 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein Yippee-Mis18 PF03226.9 ESS67558.1 - 0.065 13.2 1.7 0.9 9.6 0.2 2.5 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DER1 PF04511.10 ESS67559.1 - 4.3e-32 111.2 5.6 5e-32 111.0 3.9 1.0 1 0 0 1 1 1 1 Der1-like family ASFV_L11L PF05293.6 ESS67559.1 - 0.06 13.4 4.1 0.13 12.4 0.2 2.6 2 0 0 2 2 2 0 African swine fever virus (ASFV) L11L protein Ank_4 PF13637.1 ESS67560.1 - 3.8e-10 40.0 0.0 1.8e-06 28.2 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESS67560.1 - 6.7e-09 35.9 0.0 9.5e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS67560.1 - 4.2e-05 23.6 0.0 0.06 13.6 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 ESS67560.1 - 0.00012 21.7 0.1 0.13 12.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 ESS67560.1 - 0.0016 18.4 0.0 0.047 13.9 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Nitro_FeMo-Co PF02579.12 ESS67560.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor DUF4495 PF14906.1 ESS67561.1 - 0.0038 16.2 2.2 0.0052 15.7 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4495) Ivy PF08816.6 ESS67561.1 - 0.1 12.5 2.5 0.16 11.9 1.8 1.4 1 0 0 1 1 1 0 Inhibitor of vertebrate lysozyme (Ivy) V_ATPase_I PF01496.14 ESS67561.1 - 0.7 7.6 7.6 0.87 7.3 5.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SecD-TM1 PF13721.1 ESS67561.1 - 2 8.6 8.3 3.1 8.1 0.3 2.5 1 1 1 2 2 2 0 SecD export protein N-terminal TM region RLI PF04068.10 ESS67562.1 - 0.051 13.1 1.2 0.1 12.1 0.8 1.5 1 0 0 1 1 1 0 Possible Fer4-like domain in RNase L inhibitor, RLI IRK PF01007.15 ESS67563.1 - 0.00031 19.6 5.0 0.023 13.4 0.1 2.6 2 1 1 3 3 3 2 Inward rectifier potassium channel Ion_trans_2 PF07885.11 ESS67563.1 - 1.6 8.4 9.4 4.6 7.0 6.5 1.7 1 1 0 1 1 1 0 Ion channel RRM_1 PF00076.17 ESS67564.1 - 3.4e-17 61.8 0.0 4.3e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67564.1 - 1.2e-12 47.6 0.0 1.5e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67564.1 - 1.7e-05 24.5 0.0 2.6e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) gp12-short_mid PF09089.5 ESS67583.1 - 0.084 12.8 0.1 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Phage short tail fibre protein gp12, middle domain DUF2838 PF10998.3 ESS67584.1 - 1.3e-28 99.1 8.4 1.6e-27 95.5 3.0 4.0 4 0 0 4 4 4 2 Protein of unknown function (DUF2838) DUF788 PF05620.6 ESS67584.1 - 0.051 13.4 0.6 0.051 13.4 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF788) FAD_binding_2 PF00890.19 ESS67586.1 - 5.8e-89 298.8 0.1 1.1e-88 297.9 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain ApbE PF02424.10 ESS67586.1 - 5.9e-64 215.7 0.0 9.4e-64 215.1 0.0 1.3 1 0 0 1 1 1 1 ApbE family NAD_binding_1 PF00175.16 ESS67586.1 - 4.2e-17 62.6 0.0 1.3e-16 61.1 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DAO PF01266.19 ESS67586.1 - 1.1e-10 40.9 1.7 2.9e-07 29.7 0.6 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESS67586.1 - 4.8e-09 36.3 0.5 5.2e-06 26.4 0.3 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_6 PF00970.19 ESS67586.1 - 1.1e-08 35.1 0.0 6.9e-08 32.5 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_8 PF13450.1 ESS67586.1 - 1.3e-08 34.7 0.5 5.9e-07 29.4 0.2 3.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 ESS67586.1 - 6.6e-08 32.0 6.2 2.2e-07 30.3 4.3 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 ESS67586.1 - 8.3e-07 27.8 4.7 4e-05 22.2 1.5 2.6 2 0 0 2 2 2 2 HI0933-like protein GIDA PF01134.17 ESS67586.1 - 4e-05 22.6 5.8 0.00041 19.3 4.0 2.3 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 ESS67586.1 - 0.00021 21.4 1.1 0.0089 16.1 0.8 2.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_6 PF08030.7 ESS67586.1 - 0.00025 20.9 0.0 0.077 12.8 0.0 2.8 3 0 0 3 3 3 1 Ferric reductase NAD binding domain AlaDh_PNT_C PF01262.16 ESS67586.1 - 0.00088 18.8 0.6 0.0022 17.6 0.4 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 ESS67586.1 - 0.0017 18.7 2.6 0.0021 18.4 0.6 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESS67586.1 - 0.002 17.2 0.6 0.0044 16.1 0.4 1.6 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 ESS67586.1 - 0.0057 15.7 0.2 0.015 14.4 0.1 1.6 1 0 0 1 1 1 1 Thi4 family DUF4511 PF14974.1 ESS67586.1 - 0.023 14.4 0.0 2.2 8.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4511) Lycopene_cycl PF05834.7 ESS67586.1 - 0.027 13.3 0.7 0.051 12.4 0.5 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Aminotran_1_2 PF00155.16 ESS67588.1 - 1.1e-76 258.1 0.0 1.2e-76 258.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II CENP-B_dimeris PF09026.5 ESS67589.1 - 9.8 6.4 15.4 12 6.2 0.4 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Actin PF00022.14 ESS67591.1 - 1.6e-80 270.5 0.0 1.8e-80 270.2 0.0 1.0 1 0 0 1 1 1 1 Actin RrnaAD PF00398.15 ESS67592.1 - 2.1e-29 102.3 0.0 9.8e-29 100.1 0.0 1.8 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.7 ESS67592.1 - 0.00014 22.2 0.0 0.00082 19.8 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESS67592.1 - 0.021 13.9 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.1 ESS67592.1 - 0.046 13.4 0.0 0.094 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 ESS67592.1 - 0.065 12.9 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CBS PF00571.23 ESS67593.1 - 6.4e-12 45.0 3.6 7.1e-05 22.5 0.2 3.8 4 0 0 4 4 4 3 CBS domain FHA PF00498.21 ESS67594.1 - 1.4e-05 25.1 0.0 9e-05 22.5 0.0 2.3 1 1 0 1 1 1 1 FHA domain SET PF00856.23 ESS67595.1 - 7.3e-12 45.8 0.6 0.0035 17.6 0.0 3.7 3 0 0 3 3 3 3 SET domain Exo_endo_phos PF03372.18 ESS67597.1 - 3.6e-07 30.3 1.4 1.1e-06 28.7 1.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ATP-synt_D PF01813.12 ESS67598.1 - 5.4e-76 254.5 2.7 5.4e-76 254.5 1.9 1.3 2 0 0 2 2 2 1 ATP synthase subunit D TPR_12 PF13424.1 ESS67599.1 - 5e-64 212.2 46.2 7.3e-14 51.4 0.5 8.2 6 2 2 8 8 8 7 Tetratricopeptide repeat TPR_10 PF13374.1 ESS67599.1 - 1.5e-31 107.3 37.6 3.7e-05 23.5 0.2 11.7 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_11 PF13414.1 ESS67599.1 - 5.3e-23 80.4 44.9 1.7e-05 24.3 1.5 7.6 6 2 3 9 9 9 8 TPR repeat TPR_2 PF07719.12 ESS67599.1 - 1.1e-16 59.2 50.2 0.045 13.6 0.1 12.5 12 1 0 12 12 12 7 Tetratricopeptide repeat TPR_1 PF00515.23 ESS67599.1 - 5.8e-15 54.1 39.3 0.17 11.5 0.0 12.4 12 1 1 13 13 13 7 Tetratricopeptide repeat TPR_16 PF13432.1 ESS67599.1 - 1.2e-12 48.1 39.4 0.022 15.4 0.2 9.0 5 3 4 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.1 ESS67599.1 - 1.7e-12 46.7 38.7 0.093 13.4 0.3 11.3 8 2 4 12 12 12 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESS67599.1 - 5.6e-11 41.3 33.8 0.0062 16.2 0.5 10.5 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_7 PF13176.1 ESS67599.1 - 3.9e-10 38.7 35.1 0.13 12.1 0.0 11.5 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS67599.1 - 0.0002 21.6 30.9 0.16 12.2 0.3 8.0 7 1 3 10 10 10 3 Tetratricopeptide repeat Apc5 PF12862.2 ESS67599.1 - 0.14 11.9 18.0 0.84 9.5 0.5 5.9 4 2 2 6 6 6 0 Anaphase-promoting complex subunit 5 PAT1 PF09770.4 ESS67600.1 - 0.099 10.8 22.9 0.12 10.5 15.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FYRC PF05965.9 ESS67603.1 - 0.085 12.6 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 F/Y rich C-terminus Nup35_RRM_2 PF14605.1 ESS67604.1 - 2.7e-20 71.8 0.0 4.4e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif EI24 PF07264.6 ESS67608.1 - 0.0051 16.2 3.5 0.007 15.8 2.4 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Amastin PF07344.6 ESS67608.1 - 0.0084 15.7 3.2 0.009 15.6 2.3 1.2 1 0 0 1 1 1 1 Amastin surface glycoprotein DUF2422 PF10337.4 ESS67608.1 - 0.015 14.0 0.3 0.018 13.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Peptidase_U32 PF01136.14 ESS67608.1 - 0.021 13.7 0.6 0.025 13.5 0.4 1.1 1 0 0 1 1 1 0 Peptidase family U32 IncA PF04156.9 ESS67608.1 - 0.085 12.4 1.8 0.095 12.2 1.2 1.1 1 0 0 1 1 1 0 IncA protein VIT1 PF01988.14 ESS67608.1 - 6.8 6.1 6.7 8.1 5.8 4.7 1.1 1 0 0 1 1 1 0 VIT family WD40 PF00400.27 ESS67609.1 - 1.9e-16 59.2 17.6 2.9e-07 30.1 0.4 8.2 8 1 0 8 8 8 3 WD domain, G-beta repeat EF-hand_8 PF13833.1 ESS67609.1 - 1.3e-05 24.6 0.0 3.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 ESS67609.1 - 8.1e-05 22.6 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 ESS67609.1 - 0.00053 19.2 0.0 0.0012 18.0 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 ESS67609.1 - 0.00063 18.8 0.0 0.0014 17.7 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 ESS67609.1 - 0.006 16.3 0.0 0.021 14.6 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain DUF3989 PF13150.1 ESS67610.1 - 0.11 11.9 0.1 0.63 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) PIP5K PF01504.13 ESS67611.1 - 3.9e-58 196.5 0.0 5.6e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Pkinase PF00069.20 ESS67612.1 - 3.5e-60 203.3 0.0 5.1e-60 202.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67612.1 - 1.2e-32 112.9 0.0 1.8e-32 112.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.1 ESS67612.1 - 2.7e-07 30.6 1.8 0.021 14.9 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS67612.1 - 2.6e-06 26.8 1.8 0.0038 16.9 0.0 3.9 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 ESS67612.1 - 1e-05 24.4 0.8 0.0038 16.4 0.0 3.9 4 0 0 4 4 4 1 EF hand Kinase-like PF14531.1 ESS67612.1 - 0.00026 20.0 0.0 0.00053 19.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like EF-hand_8 PF13833.1 ESS67612.1 - 0.00078 19.0 0.8 0.28 10.8 0.0 3.4 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 ESS67612.1 - 0.039 13.2 0.1 0.14 11.5 0.1 1.9 1 0 0 1 1 1 0 EF hand DUF481 PF04338.7 ESS67616.1 - 0.14 11.8 0.3 5.8 6.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function, DUF481 Thioredoxin PF00085.15 ESS67618.1 - 3.3e-06 26.7 0.0 9e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESS67618.1 - 0.00033 20.6 0.1 0.067 13.3 0.0 2.8 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESS67618.1 - 0.0015 18.1 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 ESS67618.1 - 0.0025 17.7 0.0 0.0058 16.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like DUF3770 PF12603.3 ESS67618.1 - 0.048 12.7 0.7 0.074 12.1 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3770) Thioredoxin_2 PF13098.1 ESS67618.1 - 0.11 12.7 0.0 1.3 9.2 0.0 2.4 1 1 0 1 1 1 0 Thioredoxin-like domain Helicase_C PF00271.26 ESS67620.1 - 5.2e-21 74.2 0.3 8.1e-21 73.6 0.2 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS67621.1 - 2.1e-21 76.1 0.1 2.5e-21 75.8 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.16 ESS67621.1 - 0.091 12.0 0.7 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain ECH PF00378.15 ESS67622.1 - 1.3e-59 201.3 0.2 1.5e-59 201.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_M29 PF02073.10 ESS67623.1 - 0.029 13.1 0.0 0.043 12.5 0.0 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) EF-hand_8 PF13833.1 ESS67623.1 - 0.19 11.3 0.3 0.67 9.6 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair adh_short PF00106.20 ESS67625.1 - 1.8e-38 132.0 4.0 2.8e-38 131.4 2.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS67625.1 - 5e-23 81.7 2.4 9.3e-23 80.8 1.7 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESS67625.1 - 1.6e-19 70.6 0.0 2.4e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESS67625.1 - 2.9e-07 30.6 0.5 1e-06 28.9 0.3 1.9 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESS67625.1 - 5.9e-05 22.6 0.6 0.00024 20.6 0.4 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 ESS67625.1 - 0.0011 18.0 0.5 0.0017 17.2 0.3 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESS67625.1 - 0.0031 16.2 0.2 0.0043 15.8 0.2 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_7 PF13241.1 ESS67625.1 - 0.013 15.7 0.8 0.029 14.6 0.2 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox PF00070.22 ESS67625.1 - 0.037 14.4 1.4 0.049 14.0 0.3 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RmlD_sub_bind PF04321.12 ESS67625.1 - 0.12 11.2 0.5 0.66 8.8 0.4 2.0 1 1 0 1 1 1 0 RmlD substrate binding domain Aminotran_1_2 PF00155.16 ESS67626.1 - 3.2e-51 174.4 0.0 4.2e-51 174.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 ESS67626.1 - 0.00038 19.6 0.0 0.00056 19.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 ESS67626.1 - 0.031 13.3 0.0 0.11 11.5 0.0 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Ank_2 PF12796.2 ESS67627.1 - 1.9e-20 72.9 0.0 1.4e-16 60.6 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESS67627.1 - 1.9e-17 62.0 0.0 1.2e-05 24.8 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 ESS67627.1 - 5.3e-13 49.1 0.1 5.7e-10 39.4 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS67627.1 - 8.6e-13 47.1 0.0 0.00078 19.4 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 ESS67627.1 - 6e-11 42.2 0.1 2.4e-06 27.5 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Drc1-Sld2 PF11719.3 ESS67628.1 - 1.2e-06 27.9 8.5 0.014 14.5 0.0 2.4 2 1 0 2 2 2 2 DNA replication and checkpoint protein GRP PF07172.6 ESS67628.1 - 0.84 10.1 5.8 0.42 11.1 0.8 2.2 2 0 0 2 2 2 0 Glycine rich protein family 3HCDH PF00725.17 ESS67629.1 - 5.7e-08 33.0 0.0 0.00024 21.4 0.0 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH PF00378.15 ESS67629.1 - 8.2e-06 25.1 0.0 1.6e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ArfGap PF01412.13 ESS67630.1 - 1.5e-26 92.5 0.7 3.3e-26 91.3 0.1 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf GEMIN8 PF15348.1 ESS67630.1 - 0.23 11.4 2.3 0.36 10.8 1.6 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 TSC21 PF15217.1 ESS67631.1 - 0.15 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 TSC21 family DnaJ PF00226.26 ESS67632.1 - 3.7e-09 36.2 0.0 6.3e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain zf-RING_2 PF13639.1 ESS67634.1 - 1e-15 57.2 4.7 1.6e-15 56.6 3.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESS67634.1 - 1.6e-09 37.7 1.6 3.1e-09 36.8 1.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESS67634.1 - 2.8e-08 33.6 5.7 4.3e-08 33.0 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS67634.1 - 3.7e-08 32.9 3.3 5.7e-08 32.3 2.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS67634.1 - 9.9e-08 31.5 3.8 1.5e-07 30.9 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS67634.1 - 1.8e-05 24.3 4.8 2.7e-05 23.8 3.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESS67634.1 - 0.00099 18.8 1.3 0.002 17.9 0.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ESS67634.1 - 0.0027 17.3 3.5 0.0053 16.4 2.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger FANCL_C PF11793.3 ESS67634.1 - 0.0029 17.5 2.7 0.006 16.5 1.8 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.2 ESS67634.1 - 0.0044 17.0 5.1 0.0074 16.3 3.5 1.4 1 0 0 1 1 1 1 RING-variant domain Rtf2 PF04641.7 ESS67634.1 - 0.0058 15.8 0.1 0.0089 15.2 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger Baculo_RING PF05883.6 ESS67634.1 - 0.019 14.7 0.5 0.033 14.0 0.3 1.3 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING_4 PF14570.1 ESS67634.1 - 0.032 13.7 2.5 0.055 13.0 1.7 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 ESS67634.1 - 0.062 13.1 4.1 0.11 12.3 2.9 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.24 ESS67634.1 - 0.067 12.8 3.9 0.11 12.1 2.7 1.4 1 0 0 1 1 1 0 PHD-finger PCMT PF01135.14 ESS67634.1 - 0.13 11.7 0.0 8 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-RING-like PF08746.6 ESS67634.1 - 0.43 10.6 4.0 0.73 9.8 2.8 1.4 1 0 0 1 1 1 0 RING-like domain YscO PF07321.7 ESS67635.1 - 9.1e-30 103.4 17.0 9.1e-30 103.4 11.8 11.7 7 4 5 12 12 12 1 Type III secretion protein YscO DUF2407_C PF13373.1 ESS67636.1 - 6.1 6.7 12.5 2.7 7.9 0.2 3.4 4 1 0 4 4 4 0 DUF2407 C-terminal domain CorA PF01544.13 ESS67636.1 - 9.7 5.1 14.6 0.53 9.2 3.0 2.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Dzip-like_N PF13815.1 ESS67637.1 - 0.0052 16.5 0.0 0.0052 16.5 0.0 5.9 3 1 1 4 4 3 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal CCDC155 PF14662.1 ESS67637.1 - 0.0059 16.2 55.7 0.04 13.4 0.6 5.1 3 1 2 5 5 5 3 Coiled-coil region of CCDC155 ADIP PF11559.3 ESS67637.1 - 0.017 14.9 60.7 0.031 14.1 10.7 4.2 4 0 0 4 4 4 0 Afadin- and alpha -actinin-Binding Herpes_BLRF2 PF05812.7 ESS67637.1 - 0.073 12.8 0.4 0.073 12.8 0.3 5.3 4 1 1 5 5 5 0 Herpesvirus BLRF2 protein ATG16 PF08614.6 ESS67637.1 - 1.1 9.0 53.6 0.32 10.7 6.3 4.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.6 ESS67637.1 - 1.2 9.1 14.2 4.7 7.1 0.4 4.4 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Cbl_N PF02262.11 ESS67637.1 - 1.4 8.6 6.2 0.29 10.8 1.5 1.9 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 DivIVA PF05103.8 ESS67637.1 - 3.1 7.8 53.8 1.9 8.5 2.0 6.6 3 2 4 7 7 7 0 DivIVA protein NYD-SP28_assoc PF14775.1 ESS67637.1 - 3.3 7.4 34.7 0.58 9.8 0.5 5.7 5 0 0 5 5 5 0 Sperm tail C-terminal domain APG6 PF04111.7 ESS67637.1 - 4.4 6.2 56.9 0.042 12.8 0.5 4.2 2 1 2 4 4 4 0 Autophagy protein Apg6 BLOC1_2 PF10046.4 ESS67637.1 - 5.6 7.1 24.8 38 4.4 7.0 4.6 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prominin PF05478.6 ESS67637.1 - 9 3.6 15.6 0.37 8.2 5.5 2.0 1 1 1 2 2 2 0 Prominin NIF PF03031.13 ESS67638.1 - 3.3e-33 114.6 0.0 4.7e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESS67638.1 - 0.095 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase WD40_alt PF14077.1 ESS67639.1 - 0.37 10.4 8.9 0.38 10.4 0.2 4.3 4 0 0 4 4 4 0 Alternative WD40 repeat motif Mito_carr PF00153.22 ESS67642.1 - 0.00015 21.4 4.0 0.003 17.2 0.1 3.2 3 0 0 3 3 3 1 Mitochondrial carrier protein BBS1 PF14779.1 ESS67644.1 - 0.35 9.8 3.6 0.23 10.4 1.0 1.7 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 1 DUF2924 PF11149.3 ESS67644.1 - 1.2 9.1 11.1 0.31 11.0 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) DUF1764 PF08576.5 ESS67644.1 - 4.2 8.2 11.4 0.22 12.3 0.7 2.6 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) TrkH PF02386.11 ESS67645.1 - 8.7e-18 64.0 20.9 7.1e-10 37.9 1.8 3.9 2 2 2 4 4 4 3 Cation transport protein Band_7 PF01145.20 ESS67646.1 - 9.1e-24 84.3 1.3 1.4e-23 83.7 0.9 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family HIGH_NTase1 PF05636.6 ESS67646.1 - 0.055 12.4 0.4 0.073 12.1 0.3 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase Glyco_hydro_92 PF07971.7 ESS67646.1 - 0.077 11.6 0.1 0.094 11.3 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 Transket_pyr PF02779.19 ESS67649.1 - 7e-44 149.4 0.0 1.1e-43 148.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESS67649.1 - 2.3e-37 127.6 0.0 2.2e-36 124.5 0.0 2.1 2 0 0 2 2 2 1 Transketolase, C-terminal domain UCR_14kD PF02271.11 ESS67650.1 - 5.2e-09 35.8 0.0 1.1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Arf PF00025.16 ESS67651.1 - 3.3e-65 218.5 0.0 3.7e-65 218.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESS67651.1 - 2.9e-14 52.5 1.0 9.6e-09 34.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 ESS67651.1 - 8e-11 41.5 0.0 9.5e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 ESS67651.1 - 1.3e-10 40.9 0.0 1.6e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ESS67651.1 - 1.6e-07 30.6 0.0 2.2e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 ESS67651.1 - 3.5e-07 30.7 0.0 4.9e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESS67651.1 - 1.1e-06 28.5 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESS67651.1 - 2.6e-06 27.0 0.0 1.7e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESS67651.1 - 0.05 12.8 0.0 0.14 11.3 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.14 ESS67651.1 - 0.068 12.6 0.1 0.51 9.7 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Clat_adaptor_s PF01217.15 ESS67653.1 - 1.6e-11 44.1 0.0 2.6e-11 43.4 0.0 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.1 ESS67653.1 - 0.0043 17.0 0.0 0.005 16.7 0.0 1.2 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 Lipase_3 PF01764.20 ESS67660.1 - 0.00018 21.1 0.4 0.00045 19.8 0.3 1.7 1 1 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 ESS67660.1 - 0.012 15.1 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.2 ESS67660.1 - 0.031 14.0 0.1 0.1 12.3 0.1 1.8 1 1 1 2 2 2 0 Alpha/beta hydrolase family UPF0227 PF05728.7 ESS67660.1 - 0.14 11.8 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Acyltransferase PF01553.16 ESS67661.1 - 1.7e-18 66.2 0.0 4.4e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase LRRNT_2 PF08263.7 ESS67662.1 - 0.18 11.8 2.3 0.39 10.7 1.6 1.6 1 1 0 1 1 1 0 Leucine rich repeat N-terminal domain RXT2_N PF08595.6 ESS67664.1 - 7.2 6.3 8.3 13 5.5 5.8 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Dus PF01207.12 ESS67666.1 - 2e-54 184.5 0.4 2.7e-54 184.1 0.3 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.16 ESS67666.1 - 0.00059 19.1 0.0 0.0012 18.1 0.0 1.5 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.9 ESS67666.1 - 0.00067 18.7 0.2 0.0012 18.0 0.1 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG NMO PF03060.10 ESS67666.1 - 0.0012 18.0 0.1 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase TMP-TENI PF02581.12 ESS67666.1 - 0.017 14.2 0.1 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 Thiamine monophosphate synthase/TENI DHO_dh PF01180.16 ESS67666.1 - 0.019 13.9 0.0 0.16 10.8 0.0 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase LRR_4 PF12799.2 ESS67667.1 - 1.9e-13 49.6 0.0 7.6e-05 22.2 0.0 5.5 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS67667.1 - 1.1e-06 28.3 0.0 0.075 12.7 0.0 4.8 2 1 3 5 5 5 3 Leucine rich repeat LRR_6 PF13516.1 ESS67667.1 - 1.5e-05 24.6 0.0 2.1 8.6 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich repeat DZR PF12773.2 ESS67670.1 - 0.047 13.5 0.5 0.1 12.4 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESS67670.1 - 0.078 12.2 1.5 0.14 11.3 1.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Reo_sigmaC PF04582.7 ESS67670.1 - 0.092 11.9 11.5 0.017 14.3 2.6 2.5 2 1 0 2 2 2 0 Reovirus sigma C capsid protein zf-RanBP PF00641.13 ESS67670.1 - 0.49 9.5 2.1 0.98 8.5 1.5 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others ApoO PF09769.4 ESS67670.1 - 2.4 7.8 12.4 0.57 9.8 1.7 2.7 3 1 0 3 3 3 0 Apolipoprotein O DUF479 PF04336.7 ESS67670.1 - 5.3 7.2 14.3 4.9 7.3 0.4 3.9 2 2 1 3 3 3 0 Protein of unknown function, DUF479 HA2 PF04408.18 ESS67672.1 - 2.8e-16 59.3 0.0 3.7e-15 55.8 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS67672.1 - 1.2e-12 47.5 0.2 8e-12 44.8 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS67672.1 - 1.8e-09 37.2 0.1 4.6e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.20 ESS67672.1 - 1.4e-07 31.9 0.1 0.00015 22.2 0.0 4.2 4 0 0 4 4 4 1 Double-stranded RNA binding motif OB_NTP_bind PF07717.11 ESS67672.1 - 0.00019 21.2 0.0 0.00049 19.9 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.1 ESS67672.1 - 0.00064 19.8 0.1 0.0027 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS67672.1 - 0.0026 16.7 0.0 0.0087 14.9 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein NB-ARC PF00931.17 ESS67672.1 - 0.0096 14.8 0.0 0.018 13.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.1 ESS67672.1 - 0.012 15.3 0.0 0.15 11.7 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain KaiC PF06745.8 ESS67672.1 - 0.028 13.5 0.0 0.086 11.9 0.0 1.8 2 0 0 2 2 2 0 KaiC PhoH PF02562.11 ESS67672.1 - 0.051 12.8 0.0 0.54 9.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DUF2448 PF10476.4 ESS67673.1 - 0.002 17.7 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2448) F-box-like PF12937.2 ESS67674.1 - 0.022 14.4 0.2 0.041 13.6 0.1 1.5 1 0 0 1 1 1 0 F-box-like zf-TFIIIC PF12660.2 ESS67674.1 - 0.036 13.9 0.1 0.098 12.5 0.1 1.7 1 0 0 1 1 1 0 Putative zinc-finger of transcription factor IIIC complex SlyX PF04102.7 ESS67674.1 - 0.45 10.9 6.8 1.7 9.0 1.1 2.6 2 0 0 2 2 2 0 SlyX DUF4446 PF14584.1 ESS67674.1 - 0.76 9.6 4.3 4.3 7.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) ADIP PF11559.3 ESS67674.1 - 1.2 9.0 9.0 0.9 9.4 1.0 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc24 PF08286.6 ESS67674.1 - 2.6 7.7 6.0 0.65 9.6 0.3 2.4 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.15 ESS67674.1 - 6.6 6.5 8.7 6.2 6.6 0.8 2.4 2 0 0 2 2 2 0 Prefoldin subunit Exo_endo_phos PF03372.18 ESS67675.1 - 1.2e-16 61.3 0.0 2.5e-16 60.3 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HALZ PF02183.13 ESS67676.1 - 0.011 15.4 2.6 0.018 14.7 0.7 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper TSC22 PF01166.13 ESS67676.1 - 0.016 15.1 0.5 0.016 15.1 0.3 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family TBPIP PF07106.8 ESS67676.1 - 0.063 12.8 1.9 0.15 11.5 0.2 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIC PF04977.10 ESS67676.1 - 0.61 9.6 5.9 0.89 9.0 1.3 2.8 2 0 0 2 2 2 0 Septum formation initiator DUF904 PF06005.7 ESS67676.1 - 0.63 10.3 8.8 0.61 10.4 1.3 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF972 PF06156.8 ESS67676.1 - 2.4 8.5 7.9 0.92 9.8 1.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF972) DnaJ PF00226.26 ESS67677.1 - 2.5e-12 46.3 0.1 5.2e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DNA_pol_A PF00476.15 ESS67678.1 - 4.9e-40 137.3 0.0 5.4e-40 137.1 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase family A DUF3595 PF12166.3 ESS67680.1 - 4.9e-15 55.2 0.1 5.9e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3595) DUF3595 PF12166.3 ESS67681.1 - 1.8e-51 175.2 2.3 2.5e-51 174.8 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3595) LRR_6 PF13516.1 ESS67685.1 - 0.078 13.0 19.0 2.2 8.6 0.1 7.3 8 0 0 8 8 8 0 Leucine Rich repeat OsmC PF02566.14 ESS67686.1 - 1.2e-09 38.2 0.2 2.2e-09 37.3 0.2 1.5 1 0 0 1 1 1 1 OsmC-like protein PDDEXK_1 PF12705.2 ESS67686.1 - 0.033 13.5 0.1 0.043 13.2 0.1 1.2 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily DUF1470 PF07336.6 ESS67686.1 - 0.041 14.2 0.3 0.068 13.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1470) Salp15 PF12115.3 ESS67686.1 - 0.081 13.1 1.3 1.1 9.4 0.1 2.4 1 1 1 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation AlaDh_PNT_C PF01262.16 ESS67686.1 - 0.083 12.4 0.2 0.083 12.4 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DUF4090 PF13319.1 ESS67686.1 - 0.16 11.9 1.5 3.1 7.8 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4090) FliE PF02049.13 ESS67686.1 - 0.47 10.5 7.3 5.1 7.1 2.7 3.1 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE Uds1 PF15456.1 ESS67687.1 - 0.13 12.2 8.9 2.9 7.9 0.2 3.0 2 0 0 2 2 2 0 Up-regulated During Septation Ribosomal_S13 PF00416.17 ESS67687.1 - 0.22 12.0 0.2 0.22 12.0 0.1 2.5 2 1 1 3 3 3 0 Ribosomal protein S13/S18 DUF3234 PF11572.3 ESS67691.1 - 0.15 12.1 0.1 0.29 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3234) DUF1162 PF06650.7 ESS67695.1 - 3.7e-23 82.1 0.0 2.9e-22 79.1 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1162) Chorein_N PF12624.2 ESS67697.1 - 1.6e-32 111.5 0.0 5.3e-32 109.8 0.0 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter EAP30 PF04157.11 ESS67698.1 - 2.6e-75 252.4 0.0 3e-75 252.2 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family 2-Hacid_dh_C PF02826.14 ESS67699.1 - 5e-48 162.6 0.0 6.5e-48 162.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESS67699.1 - 4.1e-07 29.5 0.0 7e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 ESS67699.1 - 1.1e-06 28.5 0.1 2e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESS67699.1 - 3.1e-06 27.1 0.0 4.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESS67699.1 - 0.00012 22.4 0.0 0.00022 21.5 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.1 ESS67699.1 - 0.00016 21.7 0.0 0.00045 20.2 0.0 1.7 2 0 0 2 2 2 1 NADH(P)-binding AdoHcyase_NAD PF00670.16 ESS67699.1 - 0.00053 19.8 0.1 0.0016 18.2 0.1 1.8 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.1 ESS67699.1 - 0.0018 18.4 0.0 0.0035 17.5 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding ApbA PF02558.11 ESS67699.1 - 0.0063 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 ESS67699.1 - 0.0091 15.6 0.2 0.11 12.0 0.1 2.1 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 ESS67699.1 - 0.014 15.7 0.1 0.062 13.7 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Oxidored_nitro PF00148.14 ESS67699.1 - 0.022 13.3 0.0 0.032 12.8 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Saccharop_dh PF03435.13 ESS67699.1 - 0.026 13.4 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase ELFV_dehydrog PF00208.16 ESS67699.1 - 0.031 13.8 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DUF384 PF04064.8 ESS67699.1 - 0.033 13.7 0.0 4.1 7.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF384) UDPG_MGDP_dh_N PF03721.9 ESS67699.1 - 0.045 13.1 0.1 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.15 ESS67699.1 - 0.071 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF434 PF04256.7 ESS67699.1 - 0.097 12.0 0.1 0.27 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF434) 2-Hacid_dh_C PF02826.14 ESS67700.1 - 9.3e-46 155.1 0.0 1.2e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESS67700.1 - 1.1e-06 28.0 0.0 1.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 ESS67700.1 - 3.1e-06 27.1 0.1 5.5e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.10 ESS67700.1 - 5.7e-06 26.2 0.0 8.5e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESS67700.1 - 0.00022 21.5 0.1 0.00045 20.5 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.1 ESS67700.1 - 0.00027 21.0 0.0 0.0004 20.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_7 PF13241.1 ESS67700.1 - 0.0016 18.6 0.0 0.0052 17.0 0.0 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding AdoHcyase_NAD PF00670.16 ESS67700.1 - 0.0025 17.6 0.1 0.015 15.1 0.1 2.1 2 1 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ApbA PF02558.11 ESS67700.1 - 0.0051 16.2 0.0 0.0083 15.5 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 ESS67700.1 - 0.0054 16.4 0.3 0.17 11.5 0.2 2.1 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Oxidored_nitro PF00148.14 ESS67700.1 - 0.011 14.3 0.0 0.035 12.7 0.0 1.7 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Pyr_redox PF00070.22 ESS67700.1 - 0.022 15.1 0.1 0.1 12.9 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ELFV_dehydrog PF00208.16 ESS67700.1 - 0.028 14.0 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Saccharop_dh PF03435.13 ESS67700.1 - 0.053 12.4 0.0 0.075 11.9 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase UDPG_MGDP_dh_N PF03721.9 ESS67700.1 - 0.064 12.6 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.15 ESS67700.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PTEN_C2 PF10409.4 ESS67703.1 - 1.2e-09 37.9 0.0 2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.15 ESS67703.1 - 2.1e-09 37.0 0.0 5.9e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS67703.1 - 1.2e-06 28.0 0.0 2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESS67703.1 - 5.5e-05 23.2 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 ESS67703.1 - 0.00057 20.1 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Lectin_N PF03954.9 ESS67703.1 - 0.2 11.0 0.1 0.41 10.0 0.1 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain R3H-assoc PF13902.1 ESS67706.1 - 7.1e-24 84.2 1.2 9.7e-24 83.8 0.1 1.8 2 0 0 2 2 2 1 R3H-associated N-terminal domain R3H PF01424.17 ESS67706.1 - 9e-06 25.3 1.4 0.0026 17.4 0.0 3.1 2 1 1 3 3 3 2 R3H domain Zip PF02535.17 ESS67707.1 - 0.72 8.8 4.3 0.72 8.7 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 ESS67707.1 - 2 7.7 11.2 2.3 7.5 7.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3808 PF10300.4 ESS67710.1 - 2.7e-53 181.1 0.0 7.6e-52 176.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3808) TPR_11 PF13414.1 ESS67710.1 - 0.039 13.6 0.8 2 8.1 0.0 3.9 5 0 0 5 5 5 0 TPR repeat DUF1771 PF08590.5 ESS67710.1 - 0.19 11.7 2.1 1 9.3 0.0 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1771) Ring_hydroxyl_A PF00848.14 ESS67711.1 - 0.077 12.6 0.8 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) PH_8 PF15409.1 ESS67712.1 - 0.12 12.4 0.3 0.24 11.5 0.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain DEAD PF00270.24 ESS67713.1 - 5e-06 26.0 0.0 1.3e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS67713.1 - 0.00013 21.7 0.0 0.0016 18.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain EF-hand_7 PF13499.1 ESS67714.1 - 0.00012 22.1 0.1 0.00019 21.4 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS67714.1 - 0.0026 17.5 0.0 0.047 13.5 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 ESS67714.1 - 0.0029 16.7 0.0 0.044 13.0 0.0 2.4 2 0 0 2 2 2 1 EF hand IDEAL PF08858.5 ESS67714.1 - 0.15 11.6 0.3 0.97 8.9 0.1 2.2 2 0 0 2 2 2 0 IDEAL domain HMGL-like PF00682.14 ESS67715.1 - 5e-08 32.8 0.0 6.4e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 HMGL-like MutS_III PF05192.13 ESS67715.1 - 0.065 13.0 0.9 0.2 11.4 0.2 1.9 1 1 1 2 2 2 0 MutS domain III Zeta_toxin PF06414.7 ESS67716.1 - 2.7e-14 52.7 0.0 2.9e-13 49.3 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.1 ESS67716.1 - 0.00016 21.6 0.5 0.0006 19.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS67716.1 - 0.0016 19.2 0.0 0.0062 17.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 ESS67716.1 - 0.0028 16.9 0.0 0.0046 16.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 ESS67716.1 - 0.018 15.3 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Thioredoxin PF00085.15 ESS67716.1 - 0.14 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Peptidase_C15 PF01470.12 ESS67717.1 - 4.8e-09 36.3 0.0 0.00034 20.5 0.0 2.2 2 0 0 2 2 2 2 Pyroglutamyl peptidase RCC1 PF00415.13 ESS67719.1 - 4.9e-29 100.2 2.4 2e-09 37.4 0.0 4.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS67719.1 - 9.7e-16 56.9 8.6 2.9e-09 36.2 0.4 4.7 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.1 ESS67719.1 - 0.2 11.3 1.2 30 4.3 0.0 3.8 4 0 0 4 4 4 0 PapC C-terminal domain IQ PF00612.22 ESS67720.1 - 1.6e-06 27.2 49.6 0.029 13.9 1.5 8.3 7 1 1 8 8 8 6 IQ calmodulin-binding motif TPR_12 PF13424.1 ESS67720.1 - 2.8e-06 27.1 0.6 5.3e-05 23.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS67720.1 - 0.00081 19.2 0.1 0.093 12.7 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DEAD PF00270.24 ESS67721.1 - 5.4e-37 126.8 0.0 1.9e-36 125.1 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS67721.1 - 1.8e-19 69.3 0.0 4.1e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 ESS67721.1 - 7.4e-08 32.0 3.9 2.2e-07 30.6 2.7 1.8 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.10 ESS67721.1 - 0.0026 17.5 0.8 0.01 15.6 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Glyco_transf_8 PF01501.15 ESS67722.1 - 2.2e-10 40.2 0.4 1e-08 34.8 0.1 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 8 DUF4131 PF13567.1 ESS67723.1 - 1.2 8.5 9.4 1.9 7.8 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) BT1 PF03092.11 ESS67724.1 - 1.5e-78 264.4 2.5 1.9e-78 264.1 1.8 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 ESS67724.1 - 5.6e-06 25.3 8.8 0.00014 20.7 6.2 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Thia_YuaJ PF09515.5 ESS67724.1 - 0.047 13.4 5.2 0.065 12.9 3.6 1.2 1 0 0 1 1 1 0 Thiamine transporter protein (Thia_YuaJ) Na_Ca_ex PF01699.19 ESS67724.1 - 0.4 10.2 5.1 0.078 12.5 0.6 2.0 3 0 0 3 3 3 0 Sodium/calcium exchanger protein Vps54 PF07928.7 ESS67738.1 - 7.2e-41 139.4 0.0 1.7e-40 138.2 0.0 1.7 1 0 0 1 1 1 1 Vps54-like protein 3HCDH PF00725.17 ESS67740.1 - 8.7e-10 38.8 0.0 4.1e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Suc_Fer-like PF06999.7 ESS67741.1 - 3.9e-21 76.1 0.3 8.9e-21 74.9 0.1 1.4 1 1 0 1 1 1 1 Sucrase/ferredoxin-like Kelch_3 PF13415.1 ESS67742.1 - 5.2e-28 96.5 0.0 1.4e-07 31.4 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS67742.1 - 4.8e-21 74.2 0.2 1e-05 25.3 0.0 6.2 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESS67742.1 - 1.7e-19 69.1 0.0 0.00018 21.5 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ESS67742.1 - 5.4e-19 67.4 0.0 0.00038 19.9 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ESS67742.1 - 3.1e-17 62.0 2.8 0.00022 20.9 0.0 6.3 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESS67742.1 - 8.5e-14 50.6 2.2 0.0058 16.3 0.0 6.7 7 0 0 7 7 7 3 Kelch motif Ran_BP1 PF00638.13 ESS67743.1 - 0.00012 22.1 0.1 0.0014 18.7 0.0 2.6 2 1 0 2 2 2 1 RanBP1 domain NUP50 PF08911.6 ESS67743.1 - 0.003 17.8 0.1 0.003 17.8 0.1 2.4 3 0 0 3 3 3 1 NUP50 (Nucleoporin 50 kDa) Fis1_TPR_C PF14853.1 ESS67744.1 - 1.2e-10 41.0 0.3 4.6e-10 39.2 0.3 1.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 ESS67744.1 - 0.045 13.0 0.1 0.15 11.3 0.0 2.0 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.12 ESS67744.1 - 0.13 12.2 0.0 0.37 10.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2730 PF10805.3 ESS67746.1 - 0.017 14.8 0.1 0.068 12.9 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) ATP_bind_3 PF01171.15 ESS67747.1 - 4.9e-17 62.0 0.0 8.2e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 PP-loop family RecR PF02132.10 ESS67747.1 - 0.053 12.9 1.0 0.053 12.9 0.7 2.5 3 0 0 3 3 3 0 RecR protein PAPS_reduct PF01507.14 ESS67747.1 - 0.067 13.0 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF2392 PF10288.4 ESS67747.1 - 0.082 13.2 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2392) TPR_11 PF13414.1 ESS67748.1 - 2.4e-05 23.9 2.2 0.11 12.1 0.0 4.8 3 2 2 5 5 5 3 TPR repeat TPR_2 PF07719.12 ESS67748.1 - 0.00012 21.7 5.4 0.52 10.3 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS67748.1 - 0.00024 21.1 1.1 0.99 9.5 0.0 4.3 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS67748.1 - 0.0011 19.4 10.3 1.8 9.4 0.0 6.2 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS67748.1 - 0.0057 16.2 3.6 0.3 10.7 0.0 4.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS67748.1 - 0.015 15.2 7.5 5.8 6.9 0.0 5.8 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS67748.1 - 0.057 14.1 10.4 14 6.4 0.1 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS67748.1 - 0.88 10.1 4.3 31 5.3 0.0 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS67748.1 - 2.8 8.6 12.0 1e+02 3.8 0.6 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat ABC1 PF03109.11 ESS67749.1 - 7.2e-28 96.9 0.0 1.4e-27 96.0 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 ESS67749.1 - 7.7e-07 29.0 0.3 2e-06 27.7 0.2 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESS67749.1 - 1.4e-06 27.5 0.0 0.0045 16.0 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESS67749.1 - 5e-06 25.8 0.1 0.078 12.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ESS67749.1 - 0.00014 21.2 0.0 0.00027 20.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Ctr PF04145.10 ESS67749.1 - 0.072 13.1 0.2 15 5.6 0.0 2.3 2 0 0 2 2 2 0 Ctr copper transporter family TPR_11 PF13414.1 ESS67750.1 - 0.00029 20.4 0.0 0.00058 19.4 0.0 1.4 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 ESS67750.1 - 0.00044 20.8 0.1 0.0015 19.1 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS67750.1 - 0.0076 16.7 0.4 0.019 15.5 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Ank_5 PF13857.1 ESS67750.1 - 0.0096 16.1 0.0 0.032 14.4 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RabGAP-TBC PF00566.13 ESS67751.1 - 1.7e-54 184.5 0.8 2.1e-54 184.2 0.6 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RabGAP-TBC PF00566.13 ESS67753.1 - 1.4e-59 201.1 0.0 1.8e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AAA_17 PF13207.1 ESS67754.1 - 3.1e-12 47.3 15.1 4.2e-08 34.0 1.6 5.2 4 1 0 4 4 4 2 AAA domain YHS PF04945.8 ESS67754.1 - 2.3e-10 40.1 4.4 4.6e-05 23.1 0.1 5.1 5 0 0 5 5 5 2 YHS domain ADK PF00406.17 ESS67754.1 - 1.1e-06 28.5 1.3 0.00047 20.0 0.0 3.6 4 0 0 4 4 4 1 Adenylate kinase AAA_18 PF13238.1 ESS67754.1 - 0.0076 16.5 0.1 0.0076 16.5 0.1 5.5 5 2 1 6 6 6 1 AAA domain AAA PF00004.24 ESS67754.1 - 0.0085 16.2 0.0 0.041 14.0 0.0 2.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 ESS67754.1 - 0.017 15.0 0.0 0.017 15.0 0.0 4.7 5 0 0 5 5 5 0 Shikimate kinase AAA_22 PF13401.1 ESS67754.1 - 0.045 13.9 0.0 0.56 10.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain OTU PF02338.14 ESS67755.1 - 7.4e-12 45.9 0.0 1e-11 45.4 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease Methyltransf_26 PF13659.1 ESS67755.1 - 0.0023 17.9 0.3 0.8 9.7 0.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain ADIP PF11559.3 ESS67758.1 - 0.48 10.3 6.1 0.48 10.3 0.1 2.1 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding APG6 PF04111.7 ESS67758.1 - 0.51 9.3 5.7 0.71 8.8 4.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DASH_Spc19 PF08287.6 ESS67758.1 - 1.1 8.8 7.3 1.8 8.1 5.1 1.4 1 1 0 1 1 1 0 Spc19 TMF_TATA_bd PF12325.3 ESS67758.1 - 4.4 7.0 12.4 4 7.1 3.4 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Peptidase_M16_C PF05193.16 ESS67759.1 - 0.19 11.3 1.7 0.34 10.5 0.2 2.2 3 0 0 3 3 3 0 Peptidase M16 inactive domain DUF342 PF03961.8 ESS67759.1 - 0.79 8.0 3.9 0.86 7.9 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.10 ESS67759.1 - 8.4 5.4 15.7 0.46 9.6 5.3 2.4 1 1 1 2 2 2 0 Exonuclease VII, large subunit SpoV PF08183.6 ESS67760.1 - 2.4e-05 23.9 0.0 4.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Stage V sporulation protein family Tmemb_185A PF10269.4 ESS67761.1 - 2.4e-09 37.1 41.3 1.8e-06 27.7 9.3 2.9 1 1 2 3 3 3 3 Transmembrane Fragile-X-F protein DnaJ PF00226.26 ESS67761.1 - 0.068 12.9 0.6 3.2 7.5 0.0 2.4 2 0 0 2 2 2 0 DnaJ domain DUF3154 PF11351.3 ESS67761.1 - 0.2 11.3 2.0 0.53 10.0 1.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3154) Per1 PF04080.8 ESS67761.1 - 1.4 8.3 0.0 1.4 8.3 0.0 3.7 3 1 1 4 4 4 0 Per1-like DUF2207 PF09972.4 ESS67761.1 - 4.6 5.7 7.9 0.31 9.5 1.3 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF2663 PF10864.3 ESS67761.1 - 7.1 6.8 9.6 0.5 10.5 0.1 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF2663) MMPL PF03176.10 ESS67763.1 - 2.9e-22 78.8 9.6 4.5e-22 78.1 6.7 1.2 1 0 0 1 1 1 1 MMPL family MMPL PF03176.10 ESS67764.1 - 1.1e-28 99.9 11.8 2.1e-28 99.0 8.2 1.4 1 1 0 1 1 1 1 MMPL family LmjF365940-deam PF14421.1 ESS67765.1 - 1.1e-44 152.1 0.0 4.3e-22 78.4 0.0 2.4 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases zf-CCCH PF00642.19 ESS67765.1 - 0.0021 17.6 1.1 0.0075 15.9 0.8 2.0 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS67765.1 - 0.0064 16.4 0.3 0.019 14.9 0.2 1.9 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type dCMP_cyt_deam_1 PF00383.17 ESS67765.1 - 0.063 12.9 0.0 0.2 11.3 0.0 1.8 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF4131 PF13567.1 ESS67766.1 - 0.56 9.5 6.4 1.9 7.8 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Taxilin PF09728.4 ESS67767.1 - 7.8e-10 38.3 45.2 1e-09 37.9 31.3 1.2 1 0 0 1 1 1 1 Myosin-like coiled-coil protein NPV_P10 PF05531.7 ESS67767.1 - 0.43 10.8 6.8 31 4.8 0.1 4.0 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein GAS PF13851.1 ESS67767.1 - 2.8 7.0 50.6 0.42 9.7 16.2 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 ESS67767.1 - 6.8 6.2 48.1 0.5 9.9 11.8 2.9 1 1 1 2 2 2 0 IncA protein Glyco_hydro_42 PF02449.10 ESS67768.1 - 0.049 12.7 0.1 0.052 12.6 0.1 1.1 1 0 0 1 1 1 0 Beta-galactosidase DUF1525 PF07511.6 ESS67768.1 - 0.1 12.5 4.4 0.12 12.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) UPF0565 PF10561.4 ESS67768.1 - 0.6 8.9 4.3 0.32 9.8 1.5 1.5 1 1 1 2 2 2 0 Uncharacterised protein family UPF0565 RNase_H2-Ydr279 PF09468.5 ESS67768.1 - 1.5 7.9 18.3 1.9 7.6 12.7 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) SRP_SPB PF02978.14 ESS67768.1 - 2.4 8.4 8.4 0.34 11.1 1.8 2.1 1 1 1 2 2 2 0 Signal peptide binding domain CDP-OH_P_transf PF01066.16 ESS67770.1 - 1.5e-13 50.9 10.0 1.5e-13 50.9 7.0 3.3 1 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4516 PF14990.1 ESS67770.1 - 0.0009 18.7 0.9 0.021 14.3 0.0 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4516) Gtr1_RagA PF04670.7 ESS67773.1 - 1.8e-64 217.0 0.0 2.5e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESS67773.1 - 0.00022 21.1 0.0 0.00044 20.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 ESS67773.1 - 0.00026 20.2 0.0 0.00064 18.9 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 ESS67773.1 - 0.0012 19.3 0.0 0.0071 16.8 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Pro-rich_19 PF15455.1 ESS67773.1 - 0.016 14.2 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 Proline-rich 19 DUF910 PF06014.6 ESS67773.1 - 0.12 12.2 0.0 0.43 10.5 0.0 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) Endotoxin_N PF03945.9 ESS67774.1 - 0.17 11.2 0.0 0.37 10.1 0.0 1.4 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain SLEI_Leptospira PF07620.6 ESS67776.1 - 0.14 12.0 0.1 0.28 11.0 0.1 1.6 1 0 0 1 1 1 0 SLEI DUF4415 PF14384.1 ESS67777.1 - 0.35 11.0 2.3 0.42 10.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4415) DUF3106 PF11304.3 ESS67777.1 - 0.64 10.4 9.6 6.6 7.1 0.3 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3106) DUF1857 PF08982.6 ESS67778.1 - 0.09 12.3 0.5 0.23 11.0 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1857) Ribosomal_L17 PF01196.14 ESS67778.1 - 0.14 12.7 3.6 0.25 11.9 2.5 1.5 1 0 0 1 1 1 0 Ribosomal protein L17 Gcd10p PF04189.8 ESS67780.1 - 1.8e-71 240.7 0.0 2.3e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family RAB3GAP2_N PF14655.1 ESS67781.1 - 1.2e-08 34.4 0.1 3.3e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus TruD PF01142.13 ESS67783.1 - 2.3e-46 158.1 0.0 6e-39 133.7 0.0 3.0 3 1 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) Drf_DAD PF06345.6 ESS67783.1 - 1.9 8.4 3.9 12 5.9 0.6 2.7 2 0 0 2 2 2 0 DRF Autoregulatory Domain Cullin_binding PF03556.10 ESS67786.1 - 5.6e-29 100.6 2.6 1e-28 99.8 1.8 1.4 1 0 0 1 1 1 1 Cullin binding Glyoxalase_2 PF12681.2 ESS67786.1 - 0.11 13.1 0.2 0.64 10.6 0.0 2.0 1 1 0 2 2 2 0 Glyoxalase-like domain RR_TM4-6 PF06459.7 ESS67788.1 - 1.6 8.5 4.5 3.1 7.6 3.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Atg8 PF02991.11 ESS67789.1 - 0.026 14.4 0.3 0.058 13.3 0.2 1.5 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like OB_NTP_bind PF07717.11 ESS67790.1 - 4.4e-22 78.0 0.0 9e-22 77.0 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESS67790.1 - 5.8e-13 48.7 0.1 1.5e-12 47.4 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS67790.1 - 2.3e-12 46.5 0.0 5.6e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS67790.1 - 2.8e-11 43.1 0.1 1.3e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS67790.1 - 7.7e-06 26.0 0.0 2.4e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS67790.1 - 0.0036 16.2 0.0 0.011 14.6 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 ESS67790.1 - 0.02 14.3 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.1 ESS67790.1 - 0.029 14.3 0.0 0.088 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 ESS67790.1 - 0.037 13.5 0.0 0.091 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.10 ESS67790.1 - 0.045 13.5 0.1 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_14 PF13173.1 ESS67790.1 - 0.12 12.3 0.0 2.1 8.2 0.0 2.5 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESS67790.1 - 0.12 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_23 PF13476.1 ESS67790.1 - 0.22 11.8 0.1 0.46 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cyclin_N PF00134.18 ESS67792.1 - 0.0042 16.6 0.0 0.032 13.7 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain PRA1 PF03208.14 ESS67793.1 - 1.4e-08 34.2 1.8 2.3e-08 33.5 1.3 1.3 1 0 0 1 1 1 1 PRA1 family protein tRNA-synt_1 PF00133.17 ESS67794.1 - 6.7e-218 724.5 1.4 5.8e-217 721.4 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESS67794.1 - 2e-26 92.5 0.2 5.6e-26 91.1 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESS67794.1 - 4.8e-16 58.4 1.7 8.4e-07 27.9 0.2 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 ESS67794.1 - 0.012 14.7 0.2 0.18 10.8 0.0 2.7 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain NERD PF08378.6 ESS67795.1 - 2.8e-22 79.1 0.1 5e-22 78.3 0.1 1.4 1 0 0 1 1 1 1 Nuclease-related domain Mrr_cat PF04471.7 ESS67795.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease Adaptin_N PF01602.15 ESS67798.1 - 2.4e-80 270.3 4.3 3.2e-80 269.9 3.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region B2-adapt-app_C PF09066.5 ESS67798.1 - 5.6e-26 90.6 0.0 1.4e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.1 ESS67798.1 - 1.1e-10 41.6 0.8 0.0071 16.6 0.0 4.5 2 2 3 5 5 5 3 HEAT repeats Cnd1 PF12717.2 ESS67798.1 - 7.2e-09 35.7 3.2 6.3e-06 26.1 0.2 3.3 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 ESS67798.1 - 1.5e-05 24.6 7.8 0.031 14.3 0.0 6.6 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.1 ESS67798.1 - 0.0003 21.1 3.6 0.11 12.9 0.1 4.6 5 1 1 6 6 6 1 HEAT-like repeat DUF3554 PF12074.3 ESS67798.1 - 0.0093 15.4 0.0 0.22 10.9 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3554) HTH_36 PF13730.1 ESS67798.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain S-antigen PF05756.6 ESS67798.1 - 0.23 11.4 2.8 0.7 9.8 1.9 1.8 1 0 0 1 1 1 0 S-antigen protein CENP-B_dimeris PF09026.5 ESS67798.1 - 2.6 8.3 8.1 5.7 7.2 4.5 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CesT PF05932.8 ESS67799.1 - 3.6e-17 62.3 0.0 5.7e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Tir chaperone protein (CesT) family ubiquitin PF00240.18 ESS67799.1 - 0.048 13.0 0.1 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin family FlaC_arch PF05377.6 ESS67799.1 - 0.059 13.2 0.5 2 8.3 0.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.16 ESS67799.1 - 0.079 12.9 0.2 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor DUF2514 PF10721.4 ESS67799.1 - 0.11 12.2 0.2 0.2 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Golgin_A5 PF09787.4 ESS67799.1 - 0.4 9.1 5.5 0.51 8.8 3.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Macoilin PF09726.4 ESS67799.1 - 0.66 8.1 4.2 0.82 7.8 2.9 1.1 1 0 0 1 1 1 0 Transmembrane protein HALZ PF02183.13 ESS67799.1 - 3.9 7.2 5.9 0.32 10.7 0.5 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper HEAT_2 PF13646.1 ESS67800.1 - 0.035 14.3 0.8 0.098 12.9 0.0 2.0 2 1 0 2 2 2 0 HEAT repeats Arm PF00514.18 ESS67800.1 - 0.046 13.5 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat HrpB2 PF09487.5 ESS67800.1 - 0.089 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) DUF2356 PF10189.4 ESS67801.1 - 0.033 13.2 0.8 0.18 10.8 0.1 2.3 2 0 0 2 2 2 0 Conserved protein (DUF2356) KTI12 PF08433.5 ESS67802.1 - 2.7e-05 23.5 0.3 0.22 10.7 0.1 3.0 2 2 0 2 2 2 2 Chromatin associated protein KTI12 AAA_33 PF13671.1 ESS67802.1 - 0.00015 21.6 3.7 0.00035 20.4 0.8 2.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESS67802.1 - 0.00067 19.9 3.1 0.012 15.9 1.0 2.9 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.15 ESS67802.1 - 0.0024 17.5 0.3 0.025 14.2 0.0 2.2 2 0 0 2 2 2 1 Adenylylsulphate kinase Zeta_toxin PF06414.7 ESS67802.1 - 0.0048 16.0 0.1 0.015 14.4 0.1 1.9 1 1 0 1 1 1 1 Zeta toxin CPT PF07931.7 ESS67802.1 - 0.01 15.4 2.3 0.22 11.1 0.1 3.2 4 0 0 4 4 4 0 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.1 ESS67802.1 - 0.011 16.5 0.8 0.036 14.8 0.1 2.4 2 2 0 2 2 2 0 AAA domain AAA_19 PF13245.1 ESS67802.1 - 0.029 14.1 0.2 0.15 11.8 0.0 2.2 2 0 0 2 2 2 0 Part of AAA domain AAA_16 PF13191.1 ESS67802.1 - 0.035 14.1 2.8 0.11 12.5 0.2 2.9 3 1 1 4 4 4 0 AAA ATPase domain AAA_22 PF13401.1 ESS67802.1 - 0.08 13.0 0.2 0.7 10.0 0.1 2.4 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESS67802.1 - 0.1 12.9 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter PCIF1_WW PF12237.3 ESS67803.1 - 8.9e-54 181.4 0.0 1.4e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain HlyIII PF03006.15 ESS67804.1 - 3.1e-55 186.9 29.2 3.9e-55 186.6 20.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF754 PF05449.6 ESS67804.1 - 1.5 8.9 8.9 1.7 8.7 0.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF754) DUF2101 PF09874.4 ESS67805.1 - 0.18 11.2 2.2 0.19 11.2 1.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) YfhO PF09586.5 ESS67805.1 - 1.8 6.4 5.6 2 6.2 3.9 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO HlyIII PF03006.15 ESS67806.1 - 1.5e-56 191.2 28.9 1.9e-56 190.9 20.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF2933 PF11666.3 ESS67806.1 - 0.016 14.7 0.1 0.016 14.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2933) PSP1 PF04468.7 ESS67808.1 - 2.8e-05 24.0 0.0 5.4e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Rota_NS6 PF04866.7 ESS67809.1 - 0.31 11.0 2.4 0.62 10.0 0.1 2.5 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 Pox_I6 PF04595.8 ESS67810.1 - 0.06 12.0 0.0 0.077 11.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus I6-like family DAO PF01266.19 ESS67811.1 - 2.6e-40 138.4 0.0 3.6e-40 137.9 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESS67811.1 - 0.00054 19.9 0.0 0.0015 18.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESS67811.1 - 0.0039 17.1 0.0 0.056 13.3 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 ESS67811.1 - 0.0072 16.3 0.1 0.04 13.9 0.0 2.2 2 0 0 2 2 2 1 TrkA-N domain Pyr_redox_3 PF13738.1 ESS67811.1 - 0.0079 16.2 0.0 0.068 13.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESS67811.1 - 0.037 12.9 0.0 0.079 11.8 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein LRR_4 PF12799.2 ESS67812.1 - 5.4e-09 35.4 0.4 0.011 15.3 0.0 3.1 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS67812.1 - 0.00018 21.1 1.2 0.026 14.2 0.1 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 ESS67812.1 - 0.0016 18.1 0.1 13 6.2 0.0 3.8 3 1 0 3 3 3 2 Leucine Rich Repeat EMP24_GP25L PF01105.19 ESS67813.1 - 2.3e-15 56.7 0.0 2.7e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD HMG_box_2 PF09011.5 ESS67816.1 - 0.00032 20.9 9.1 0.059 13.7 0.0 2.8 2 1 0 2 2 2 2 HMG-box domain EF-hand_7 PF13499.1 ESS67817.1 - 6.8e-16 58.1 0.2 5.1e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESS67817.1 - 1.2e-12 46.5 0.0 4.4e-05 23.0 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 ESS67817.1 - 3.6e-11 42.5 2.1 2.8e-07 30.0 0.2 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 ESS67817.1 - 1e-10 40.1 1.4 0.0001 21.3 0.0 4.8 5 1 0 5 5 5 2 EF hand EFhand_Ca_insen PF08726.5 ESS67817.1 - 9.7e-07 28.6 0.4 0.016 15.1 0.1 2.4 2 0 0 2 2 2 2 Ca2+ insensitive EF hand EF-hand_5 PF13202.1 ESS67817.1 - 0.00017 20.7 0.1 0.49 9.8 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.1 ESS67817.1 - 0.00097 19.0 0.2 0.25 11.2 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain Tenui_NCP PF04876.7 ESS67817.1 - 0.021 14.3 0.6 2.9 7.3 0.0 2.1 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein SWIM PF04434.12 ESS67818.1 - 0.065 12.7 0.4 0.13 11.7 0.3 1.5 1 0 0 1 1 1 0 SWIM zinc finger MS_channel PF00924.13 ESS67820.1 - 1.5e-17 63.5 0.2 1.8e-17 63.3 0.1 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel DAO PF01266.19 ESS67821.1 - 2.1e-18 66.3 0.1 6e-18 64.8 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESS67821.1 - 1e-08 35.0 0.5 1.4e-07 31.4 0.4 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 ESS67821.1 - 7.2e-05 21.8 1.1 0.00017 20.5 0.7 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 ESS67821.1 - 0.0001 22.2 0.1 0.00034 20.5 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESS67821.1 - 0.00063 18.8 0.1 0.0012 18.0 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 ESS67821.1 - 0.00087 19.6 2.4 0.0016 18.7 0.5 2.3 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS67821.1 - 0.00094 18.1 0.4 0.002 17.0 0.3 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.9 ESS67821.1 - 0.00099 17.6 0.3 0.0019 16.7 0.2 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.1 ESS67821.1 - 0.0028 17.7 0.5 0.0062 16.6 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 ESS67821.1 - 0.0095 15.6 0.5 0.021 14.4 0.4 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.1 ESS67821.1 - 0.011 15.4 0.4 0.039 13.7 0.1 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 ESS67821.1 - 0.019 14.0 0.1 0.045 12.7 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.7 ESS67821.1 - 0.031 13.1 0.1 0.056 12.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein THP2 PF09432.5 ESS67821.1 - 0.047 13.5 0.1 3.1 7.6 0.0 2.8 2 0 0 2 2 2 0 Tho complex subunit THP2 Amino_oxidase PF01593.19 ESS67821.1 - 0.056 12.5 0.1 0.085 11.9 0.1 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase 2-Hacid_dh_C PF02826.14 ESS67821.1 - 0.12 11.5 0.0 0.28 10.2 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SAS4 PF15460.1 ESS67821.1 - 0.13 12.1 2.5 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 FAD_binding_1 PF00667.15 ESS67841.1 - 3.4e-32 111.6 0.0 6.1e-31 107.5 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 ESS67841.1 - 1.8e-18 66.9 0.1 1.9e-17 63.5 0.1 2.2 1 1 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 ESS67841.1 - 4e-09 37.0 0.0 1.6e-08 35.0 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESS67841.1 - 0.00013 21.9 0.0 0.00069 19.7 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain RRM_1 PF00076.17 ESS67842.1 - 9.7e-24 82.7 0.1 2.1e-13 49.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67842.1 - 3.4e-22 78.1 0.4 1.9e-12 46.9 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67842.1 - 3.9e-06 26.6 0.1 0.012 15.4 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.5 ESS67842.1 - 0.013 15.3 0.1 0.07 13.0 0.0 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) CDC37_N PF03234.9 ESS67844.1 - 2.6 8.3 7.8 18 5.5 2.8 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding zf-RING_2 PF13639.1 ESS67845.1 - 4.9e-14 51.8 32.6 2.1e-07 30.6 9.6 3.4 3 0 0 3 3 3 3 Ring finger domain zf-RING_5 PF14634.1 ESS67845.1 - 1.4e-06 27.8 32.5 0.00019 21.0 9.4 3.7 3 1 0 3 3 3 2 zinc-RING finger domain zf-rbx1 PF12678.2 ESS67845.1 - 6.8e-06 26.1 21.3 0.001 19.1 5.8 3.8 3 0 0 3 3 3 2 RING-H2 zinc finger IQ PF00612.22 ESS67845.1 - 1.7e-05 24.0 3.0 0.00011 21.4 2.1 2.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-C3HC4_2 PF13923.1 ESS67845.1 - 0.28 11.2 32.3 0.8 9.7 9.4 3.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS67845.1 - 9.3 6.1 22.7 1.2 9.0 1.6 3.6 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Glyco_hydro_42C PF08533.5 ESS67846.1 - 0.14 11.6 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain DUF1664 PF07889.7 ESS67847.1 - 0.049 13.4 1.0 0.09 12.5 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IFT57 PF10498.4 ESS67847.1 - 0.18 10.5 3.4 0.27 9.9 2.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF812 PF05667.6 ESS67847.1 - 0.29 9.5 5.8 0.46 8.9 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF1470 PF07336.6 ESS67847.1 - 3.5 7.9 7.6 9.7 6.5 5.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1470) CorA PF01544.13 ESS67847.1 - 4.4 6.2 6.1 13 4.7 3.9 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Spectrin PF00435.16 ESS67847.1 - 6.1 7.1 12.8 2.7 8.3 6.6 1.9 2 0 0 2 2 2 0 Spectrin repeat GBP_C PF02841.9 ESS67847.1 - 8.4 5.4 10.2 12 5.0 7.1 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Uso1_p115_head PF04869.9 ESS67848.1 - 0.12 11.0 0.0 0.29 9.8 0.0 1.6 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region Lambda_CIII PF02061.11 ESS67849.1 - 0.048 13.6 0.1 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Lambda Phage CIII Nop53 PF07767.6 ESS67850.1 - 5.8e-16 58.4 14.1 8.1e-16 57.9 9.8 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF4094 PF13334.1 ESS67850.1 - 0.4 11.1 8.7 0.38 11.1 2.6 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) NST1 PF13945.1 ESS67850.1 - 0.44 10.5 16.4 0.8 9.7 11.4 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator RNase_H2-Ydr279 PF09468.5 ESS67850.1 - 0.45 9.6 11.4 0.88 8.7 7.9 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) RRP7 PF12923.2 ESS67851.1 - 0.00052 20.0 6.5 0.0029 17.6 4.5 1.9 1 1 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) DUF3492 PF11997.3 ESS67851.1 - 0.0014 18.2 0.1 0.0037 16.8 0.0 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF3492) HECT PF00632.20 ESS67852.1 - 7.2e-69 232.3 0.0 1.2e-68 231.6 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) FAA_hydrolase PF01557.13 ESS67853.1 - 4.6e-46 157.0 0.0 6.1e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAM163 PF15069.1 ESS67854.1 - 0.05 14.1 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 FAM163 family Vps5 PF09325.5 ESS67855.1 - 1.2e-26 93.4 3.1 1.6e-26 93.0 2.2 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 ESS67855.1 - 2.5e-18 65.9 0.0 6.4e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 PX domain BAR PF03114.13 ESS67855.1 - 3.4e-11 43.1 3.3 3.4e-11 43.1 2.3 1.5 2 0 0 2 2 2 1 BAR domain BAR_3_WASP_bdg PF10456.4 ESS67855.1 - 1.7e-06 27.4 1.6 0.00012 21.4 1.0 2.3 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DUF1677 PF07911.8 ESS67855.1 - 0.02 15.0 0.5 0.082 13.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1677) Spore_III_AB PF09548.5 ESS67855.1 - 0.036 13.7 3.8 0.037 13.7 0.2 2.5 3 1 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) FAM92 PF06730.6 ESS67855.1 - 0.047 13.0 2.5 0.06 12.6 0.8 1.8 2 1 0 2 2 2 0 FAM92 protein TMF_TATA_bd PF12325.3 ESS67855.1 - 1.9 8.2 8.1 5.4 6.7 1.0 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESS67855.1 - 3.5 7.1 10.3 29 4.1 4.3 2.8 2 1 1 3 3 3 0 IncA protein UCH PF00443.24 ESS67856.1 - 4.4e-47 160.4 0.0 1.5e-46 158.7 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS67856.1 - 1.1e-14 54.5 0.0 2.5e-13 50.1 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.27 ESS67857.1 - 0.00045 20.0 0.8 0.014 15.2 0.3 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat LRR_6 PF13516.1 ESS67857.1 - 0.16 12.1 0.0 3 8.2 0.1 2.9 2 0 0 2 2 2 0 Leucine Rich repeat SET PF00856.23 ESS67858.1 - 3.6e-09 37.1 0.0 2.7e-05 24.5 0.0 4.3 3 2 1 4 4 4 1 SET domain DUF1764 PF08576.5 ESS67859.1 - 4.9e-15 56.1 2.1 1.1e-14 55.0 1.4 1.7 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Peptidase_M24 PF00557.19 ESS67860.1 - 1e-50 172.2 0.0 1.7e-50 171.5 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 ESS67860.1 - 7.4e-30 103.0 0.0 1.4e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain CAF1 PF04857.15 ESS67861.1 - 7.8e-13 48.3 0.0 1e-12 47.9 0.0 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease SNARE PF05739.14 ESS67862.1 - 6.9e-07 28.8 5.6 2e-06 27.4 3.9 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.20 ESS67862.1 - 0.044 13.9 6.2 0.2 11.8 0.1 2.4 2 0 0 2 2 2 0 Syntaxin HEAT PF02985.17 ESS67863.1 - 1.5e-08 34.0 2.9 0.012 15.6 0.0 7.1 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.1 ESS67863.1 - 1.5e-06 28.4 2.4 0.4 11.2 0.0 5.9 6 0 0 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.1 ESS67863.1 - 1.2e-05 25.5 0.4 1.6 9.0 0.0 5.5 4 1 0 5 5 5 2 HEAT repeats DUF1546 PF07571.8 ESS67863.1 - 0.0054 16.8 0.0 9.1 6.4 0.0 4.1 4 0 0 4 4 4 1 Protein of unknown function (DUF1546) Vac14_Fab1_bd PF12755.2 ESS67863.1 - 0.1 12.9 0.0 1.4 9.3 0.0 3.0 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Helicase_C PF00271.26 ESS67868.1 - 6e-08 32.4 0.0 2.2e-07 30.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS67868.1 - 1.1e-06 28.2 0.1 4.4e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Med15 PF09606.5 ESS67868.1 - 0.2 9.8 32.9 0.28 9.3 22.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Microvir_H PF04687.7 ESS67868.1 - 1.3 8.0 8.5 2.3 7.2 5.9 1.3 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) AAA_23 PF13476.1 ESS67868.1 - 7 6.9 12.2 22 5.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP-grasp_4 PF13535.1 ESS67869.1 - 2e-24 86.3 0.0 3.3e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESS67869.1 - 1.1e-06 27.6 0.0 0.012 14.4 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D2 PF02786.12 ESS67869.1 - 0.0096 15.2 0.0 0.13 11.4 0.0 2.1 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.9 ESS67869.1 - 0.024 14.5 0.0 0.13 12.0 0.0 2.1 1 1 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.14 ESS67869.1 - 0.13 11.8 0.1 5 6.6 0.0 2.4 3 0 0 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain NinG PF05766.7 ESS67871.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein Pkinase PF00069.20 ESS67872.1 - 1.8e-15 56.8 0.0 2.1e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67872.1 - 4.8e-08 32.3 0.0 8e-08 31.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS67872.1 - 0.0069 15.3 0.0 0.019 13.9 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Transmemb_17 PF09799.4 ESS67874.1 - 0.091 13.0 3.0 0.12 12.7 2.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein KMP11 PF03037.11 ESS67875.1 - 2.2e-42 143.5 15.9 2.4e-42 143.4 11.0 1.0 1 0 0 1 1 1 1 Kinetoplastid membrane protein 11 Apolipoprotein PF01442.13 ESS67875.1 - 0.0096 15.4 0.7 0.011 15.2 0.5 1.0 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain ARL2_Bind_BART PF11527.3 ESS67875.1 - 0.045 13.5 5.7 0.049 13.4 3.9 1.1 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART Transposase_24 PF03004.9 ESS67875.1 - 0.052 13.4 0.5 0.064 13.1 0.3 1.2 1 0 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) CBP4 PF07960.6 ESS67875.1 - 0.074 12.6 0.9 0.094 12.3 0.6 1.3 1 0 0 1 1 1 0 CBP4 Lyase_8_N PF08124.6 ESS67875.1 - 0.11 11.3 0.6 0.11 11.3 0.4 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain NA37 PF04245.8 ESS67875.1 - 0.13 11.5 4.0 0.14 11.4 2.8 1.0 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein FliD_C PF07195.7 ESS67875.1 - 0.13 11.5 1.1 0.14 11.4 0.7 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Vps54 PF07928.7 ESS67875.1 - 0.16 12.0 1.8 0.18 11.9 1.3 1.1 1 0 0 1 1 1 0 Vps54-like protein DUF922 PF06037.6 ESS67875.1 - 0.21 10.9 2.1 0.24 10.6 1.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) T5orf172 PF10544.4 ESS67875.1 - 0.23 11.8 2.3 0.23 11.8 1.6 1.1 1 0 0 1 1 1 0 T5orf172 domain FTCD_C PF04961.7 ESS67876.1 - 2.6 7.4 6.3 0.39 10.1 1.3 1.8 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase RRM_1 PF00076.17 ESS67877.1 - 7.1e-34 115.2 0.0 1.3e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67877.1 - 6.8e-30 102.8 0.1 1.1e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67877.1 - 1.3e-11 44.1 0.0 2.9e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESS67877.1 - 4.6e-05 23.0 0.2 0.19 11.5 0.0 3.5 2 2 0 2 2 2 2 Limkain b1 Endonuclease_7 PF02945.10 ESS67879.1 - 0.062 13.0 1.5 0.12 12.1 1.0 1.4 1 0 0 1 1 1 0 Recombination endonuclease VII Metallophos PF00149.23 ESS67880.1 - 1.6e-33 115.8 0.0 2.1e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Haemolytic PF01809.13 ESS67880.1 - 0.082 12.5 0.2 0.26 10.9 0.1 1.8 1 0 0 1 1 1 0 Haemolytic domain NARG2_C PF10505.4 ESS67881.1 - 0.0069 15.5 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus adh_short PF00106.20 ESS67882.1 - 1.7e-17 63.8 0.4 2.5e-17 63.2 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS67882.1 - 1.1e-07 31.7 0.3 1.7e-07 31.0 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESS67882.1 - 4.5e-05 22.9 0.0 0.00011 21.7 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESS67882.1 - 0.00015 21.6 0.0 0.00023 21.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Lipase_3 PF01764.20 ESS67883.1 - 1e-07 31.6 0.0 2.1e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.15 ESS67883.1 - 0.00012 22.4 0.0 0.00024 21.3 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 ESS67883.1 - 0.00057 19.5 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 ESS67883.1 - 0.019 14.8 0.3 0.036 13.9 0.2 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family YjeF_N PF03853.10 ESS67883.1 - 0.043 13.4 0.3 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 YjeF-related protein N-terminus adh_short PF00106.20 ESS67884.1 - 3.7e-14 53.0 0.2 1e-12 48.3 0.1 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESS67884.1 - 0.00022 21.1 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ESS67884.1 - 0.0038 16.6 0.0 0.01 15.2 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.5 ESS67884.1 - 0.0094 15.6 0.0 0.086 12.5 0.0 2.1 1 1 0 1 1 1 1 KR domain Pkinase PF00069.20 ESS67886.1 - 1.3e-59 201.4 0.0 2.1e-59 200.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67886.1 - 7.6e-29 100.5 0.0 1.7e-28 99.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS67886.1 - 6.1e-11 41.8 0.0 7.3e-10 38.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESS67886.1 - 0.011 15.4 0.0 0.05 13.3 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESS67886.1 - 0.015 14.4 0.0 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3571 PF12095.3 ESS67887.1 - 0.13 12.5 2.6 0.38 11.0 0.1 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3571) Glutaredoxin2_C PF04399.8 ESS67887.1 - 0.18 11.3 2.7 1.4 8.5 0.0 3.0 2 1 1 3 3 3 0 Glutaredoxin 2, C terminal domain FAM198 PF15051.1 ESS67890.1 - 0.063 11.9 0.0 0.099 11.3 0.0 1.2 1 0 0 1 1 1 0 FAM198 protein Rieske PF00355.21 ESS67891.1 - 1.8e-15 56.2 0.1 3.2e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DnaJ PF00226.26 ESS67894.1 - 5.3e-21 74.1 0.1 9.6e-21 73.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain LolB PF03550.9 ESS67894.1 - 0.11 12.0 0.1 0.23 11.0 0.0 1.5 2 0 0 2 2 2 0 Outer membrane lipoprotein LolB Methyltransf_23 PF13489.1 ESS67896.1 - 3.8e-15 55.9 0.0 5.9e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS67896.1 - 3.5e-13 49.8 0.0 6.9e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS67896.1 - 4.1e-10 39.1 0.0 6.1e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESS67896.1 - 1.3e-07 31.9 0.0 4.3e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS67896.1 - 6.2e-07 29.1 0.0 2.3e-06 27.3 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS67896.1 - 1.1e-05 25.6 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS67896.1 - 1.1e-05 25.3 0.0 4.3e-05 23.5 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain AsnC_trans_reg PF01037.16 ESS67896.1 - 0.0025 17.5 0.0 0.012 15.3 0.0 2.0 2 0 0 2 2 2 1 AsnC family Methyltransf_18 PF12847.2 ESS67896.1 - 0.0035 17.9 0.0 0.011 16.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Peptidase_C14 PF00656.17 ESS67897.1 - 3.1e-07 30.3 0.0 4e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.17 ESS67898.1 - 1.4e-54 185.4 0.0 1.7e-54 185.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DivIC PF04977.10 ESS67899.1 - 0.11 11.9 0.3 0.29 10.6 0.2 1.6 1 0 0 1 1 1 0 Septum formation initiator DZF PF07528.9 ESS67899.1 - 0.12 11.7 0.2 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 DZF domain Laminin_G_3 PF13385.1 ESS67903.1 - 2.5e-09 37.5 0.0 4.1e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EF-hand_1 PF00036.27 ESS67904.1 - 0.02 14.1 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_9 PF14658.1 ESS67904.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain Abi PF02517.11 ESS67905.1 - 0.049 13.7 0.1 0.092 12.8 0.1 1.4 1 0 0 1 1 1 0 CAAX protease self-immunity TPMT PF05724.6 ESS67906.1 - 2.4e-18 66.3 0.8 4.2e-16 59.0 0.1 2.4 2 1 0 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Methyltransf_26 PF13659.1 ESS67906.1 - 0.0032 17.4 0.0 0.0062 16.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS67906.1 - 0.0045 16.5 0.0 0.2 11.2 0.0 2.6 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS67906.1 - 0.011 16.3 0.0 0.12 13.0 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 ESS67906.1 - 0.074 13.4 0.0 0.39 11.1 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain Glyco_transf_43 PF03360.11 ESS67906.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 43 NARP1 PF12569.3 ESS67907.1 - 0.024 13.4 0.1 0.03 13.0 0.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 HALZ PF02183.13 ESS67908.1 - 0.063 12.9 0.4 0.063 12.9 0.3 6.8 7 1 0 7 7 7 0 Homeobox associated leucine zipper MutL_C PF08676.6 ESS67909.1 - 3.4e-30 104.5 0.0 6.9e-30 103.5 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 ESS67909.1 - 3.6e-16 58.7 0.0 1.4e-15 56.8 0.0 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 ESS67909.1 - 2.8e-08 33.5 0.2 7.9e-08 32.0 0.1 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESS67909.1 - 2.2e-06 27.3 0.1 4.9e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RTC PF01137.16 ESS67911.1 - 2.5e-51 173.6 0.1 2.9e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 ESS67911.1 - 1.8e-27 95.3 0.1 3.2e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Pro_isomerase PF00160.16 ESS67912.1 - 2.5e-12 47.2 0.0 4.5e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.20 ESS67913.1 - 2.3e-55 187.5 0.0 2.7e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67913.1 - 1.9e-17 63.2 0.0 2.8e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS67913.1 - 1.9e-08 34.3 0.0 0.00036 20.3 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS67913.1 - 0.02 14.4 0.1 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase USP7_C2 PF14533.1 ESS67914.1 - 3.2e-16 59.4 0.1 6.2e-13 48.6 0.0 2.2 1 1 0 2 2 2 2 Ubiquitin-specific protease C-terminal UCH PF00443.24 ESS67915.1 - 4.2e-51 173.6 1.4 5.2e-51 173.3 1.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS67915.1 - 1.5e-24 86.9 0.2 2e-24 86.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UDPGT PF00201.13 ESS67916.1 - 2.7e-17 62.5 0.0 3.5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase RNase_H PF00075.19 ESS67917.1 - 1.5e-13 51.2 0.0 2.3e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 RNase H DAN PF03045.10 ESS67917.1 - 0.13 11.6 2.1 0.28 10.6 0.0 2.4 2 0 0 2 2 2 0 DAN domain Phage_integrase PF00589.17 ESS67919.1 - 0.00056 19.6 3.2 0.00075 19.2 0.8 2.3 2 1 0 2 2 2 1 Phage integrase family PGC7_Stella PF15549.1 ESS67919.1 - 0.026 14.5 0.7 0.27 11.2 0.2 2.3 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain Endonuclease_NS PF01223.18 ESS67939.1 - 3.4e-57 193.4 0.0 5.1e-57 192.8 0.0 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.1 ESS67939.1 - 0.015 15.3 0.7 0.048 13.7 0.5 1.8 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease NHL PF01436.16 ESS67942.1 - 0.00039 20.2 0.1 0.027 14.4 0.0 3.2 2 0 0 2 2 2 1 NHL repeat DUF1416 PF07210.7 ESS67942.1 - 0.13 11.9 0.1 0.99 9.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1416) Mito_carr PF00153.22 ESS67943.1 - 1.1e-54 182.1 1.8 3.3e-22 77.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Colicin_V PF02674.11 ESS67943.1 - 0.065 13.0 0.3 1.9 8.3 0.0 2.9 3 0 0 3 3 3 0 Colicin V production protein zf-CCCH PF00642.19 ESS67944.1 - 0.033 13.8 4.6 0.033 13.8 3.2 2.5 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ATP_synt_H PF05493.8 ESS67947.1 - 0.0058 16.6 4.4 0.024 14.6 3.1 2.0 1 0 0 1 1 1 1 ATP synthase subunit H DUF1751 PF08551.5 ESS67947.1 - 0.057 13.7 3.0 0.11 12.8 0.8 2.2 2 1 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) RecR PF02132.10 ESS67948.1 - 0.025 13.9 0.2 0.084 12.3 0.1 1.9 1 0 0 1 1 1 0 RecR protein Remorin_C PF03763.8 ESS67948.1 - 0.32 10.5 31.3 0.04 13.4 1.0 4.5 2 1 2 5 5 5 0 Remorin, C-terminal region HEAT PF02985.17 ESS67949.1 - 5.2e-09 35.4 21.7 0.018 15.0 0.1 9.4 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.1 ESS67949.1 - 1.5e-05 25.1 22.9 0.98 9.7 4.2 7.0 5 2 1 6 6 6 3 HEAT repeats HEAT_EZ PF13513.1 ESS67949.1 - 0.0072 16.7 12.6 1.2 9.7 0.1 5.9 5 1 0 5 5 5 2 HEAT-like repeat RRM_1 PF00076.17 ESS67950.1 - 3.1e-39 132.4 2.0 1.5e-16 59.7 0.0 4.8 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS67950.1 - 3.1e-37 126.3 0.3 4.5e-15 55.3 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67950.1 - 2.6e-22 78.4 0.2 3.3e-09 36.4 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 ESS67950.1 - 0.067 12.9 0.2 2.1 8.1 0.0 3.4 3 1 0 3 3 3 0 Limkain b1 dCMP_cyt_deam_1 PF00383.17 ESS67951.1 - 4e-14 52.0 1.0 2.8e-12 46.1 0.7 2.3 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 ESS67951.1 - 0.078 12.8 3.6 0.48 10.2 2.5 2.1 1 1 0 1 1 1 0 Bd3614-like deaminase MTHFR PF02219.12 ESS67955.1 - 0.00013 21.2 0.0 0.054 12.5 0.0 2.2 2 0 0 2 2 2 2 Methylenetetrahydrofolate reductase Nup160 PF11715.3 ESS67955.1 - 0.0044 15.2 0.1 0.0066 14.6 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 WD40 PF00400.27 ESS67957.1 - 2.8e-81 264.7 20.7 3.7e-10 39.2 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat Nup160 PF11715.3 ESS67957.1 - 1.1e-06 27.1 9.1 0.74 7.8 1.5 5.7 1 1 3 4 4 4 3 Nucleoporin Nup120/160 CEP19 PF14933.1 ESS67957.1 - 0.0023 18.2 0.0 0.0033 17.7 0.0 1.2 1 0 0 1 1 1 1 CEP19-like protein DUF4189 PF13827.1 ESS67957.1 - 0.66 10.2 5.9 0.24 11.6 0.6 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4189) UPF0506 PF11703.3 ESS67957.1 - 3.4 7.6 9.7 21 5.1 0.6 4.2 4 0 0 4 4 4 0 UPF0506 DUF3357 PF11837.3 ESS67959.1 - 0.83 9.5 8.7 3.4 7.5 1.0 4.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3357) TMP_2 PF06791.8 ESS67961.1 - 0.092 12.3 0.8 0.15 11.6 0.6 1.2 1 0 0 1 1 1 0 Prophage tail length tape measure protein PSK_trans_fac PF07704.6 ESS67961.1 - 1.5 9.5 5.3 16 6.2 0.2 3.7 3 0 0 3 3 3 0 Rv0623-like transcription factor CDC45 PF02724.9 ESS67964.1 - 1.2 7.1 12.5 2.1 6.2 8.7 1.3 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.5 ESS67964.1 - 1.3 9.2 20.0 4.1 7.7 13.9 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.7 ESS67964.1 - 3.3 6.8 7.9 6.5 5.9 5.5 1.4 1 0 0 1 1 1 0 NOA36 protein TPR_11 PF13414.1 ESS67965.1 - 0.00045 19.8 2.4 0.001 18.6 0.5 2.5 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 ESS67965.1 - 0.0088 15.8 5.9 0.46 10.5 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF2153 PF09921.4 ESS67965.1 - 0.052 13.1 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) TPR_1 PF00515.23 ESS67965.1 - 0.24 11.0 3.3 0.4 10.3 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS67965.1 - 0.58 10.1 3.9 0.56 10.1 0.8 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 ESS67966.1 - 1.6e-14 53.7 0.0 2.3e-08 33.5 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS67966.1 - 0.0018 17.3 0.0 0.035 13.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS67966.1 - 0.027 14.2 0.1 0.93 9.1 0.1 2.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESS67966.1 - 0.042 12.8 0.0 0.092 11.7 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1168 PF06658.7 ESS67966.1 - 0.47 9.9 16.5 0.78 9.2 11.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DDRGK PF09756.4 ESS67966.1 - 1.7 8.0 13.5 2.6 7.3 9.4 1.2 1 0 0 1 1 1 0 DDRGK domain A_deaminase PF00962.17 ESS67968.1 - 9.7e-08 31.2 0.4 0.0038 16.1 0.0 2.9 3 0 0 3 3 3 2 Adenosine/AMP deaminase Nop16 PF09420.5 ESS67969.1 - 7.2e-32 110.7 2.3 2.4e-31 109.0 1.6 1.7 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 RYDR_ITPR PF01365.16 ESS67969.1 - 0.15 11.2 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 RIH domain DUF4239 PF14023.1 ESS67970.1 - 0.097 12.0 5.4 0.039 13.3 0.9 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) IQ PF00612.22 ESS67973.1 - 0.00015 21.0 64.3 0.0016 17.8 1.8 9.6 10 0 0 10 10 10 6 IQ calmodulin-binding motif Ras PF00071.17 ESS67974.1 - 6.4e-59 197.9 0.1 8e-59 197.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS67974.1 - 6.3e-19 68.6 0.0 1e-18 67.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS67974.1 - 1.2e-13 50.6 0.1 1.7e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESS67974.1 - 2.7e-06 27.3 0.0 5.4e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESS67974.1 - 5e-06 26.0 0.0 4.8e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESS67974.1 - 0.0018 17.4 0.1 0.0038 16.4 0.0 1.7 2 1 0 2 2 2 1 Protein of unknown function, DUF258 MobB PF03205.9 ESS67974.1 - 0.0053 16.4 0.9 0.54 9.9 0.0 2.4 1 1 1 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 ESS67974.1 - 0.0078 16.3 0.0 0.013 15.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESS67974.1 - 0.0083 15.3 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESS67974.1 - 0.0091 15.1 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_15 PF13175.1 ESS67974.1 - 0.011 14.8 0.1 0.014 14.4 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.1 ESS67974.1 - 0.068 12.7 0.0 0.093 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Septin PF00735.13 ESS67974.1 - 0.078 11.9 0.1 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_29 PF13555.1 ESS67974.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Neur_chan_memb PF02932.11 ESS67976.1 - 0.02 14.7 0.2 0.02 14.7 0.1 3.6 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ly49 PF08391.5 ESS67976.1 - 0.16 12.1 0.0 0.16 12.1 0.0 3.2 4 0 0 4 4 4 0 Ly49-like protein, N-terminal region PEX11 PF05648.9 ESS67977.1 - 0.0014 17.9 0.9 0.012 14.9 0.1 2.2 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) DUF2255 PF10012.4 ESS67977.1 - 0.093 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) IF-2B PF01008.12 ESS67978.1 - 1.4e-38 132.5 0.0 9.7e-38 129.7 0.0 2.1 1 1 0 1 1 1 1 Initiation factor 2 subunit family Baculo_PEP_C PF04513.7 ESS67979.1 - 1.7 8.4 4.9 2.8 7.7 0.0 3.2 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2181 PF10223.4 ESS67980.1 - 5.2e-11 42.3 0.0 7.5e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) DUF422 PF04240.7 ESS67980.1 - 0.018 14.4 0.1 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF422) P34-Arc PF04045.9 ESS67981.1 - 3.6e-32 111.5 0.3 4.6e-32 111.2 0.2 1.2 1 1 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc PNP_UDP_1 PF01048.15 ESS67982.1 - 1.8e-55 187.4 0.9 2.1e-55 187.2 0.6 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Mito_carr PF00153.22 ESS67983.1 - 7.4e-25 86.4 5.9 8e-09 35.1 0.4 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein RRM_6 PF14259.1 ESS67984.1 - 1.1e-10 41.3 0.0 2.5e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS67984.1 - 1.5e-09 37.3 0.0 3.8e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS67984.1 - 1.3e-06 28.1 0.3 3.3e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1042 PF06294.6 ESS67985.1 - 2.1e-15 56.6 0.6 4.7e-15 55.5 0.0 1.9 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 ESS67985.1 - 5.5e-07 29.1 0.0 1.1e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LRAT PF04970.8 ESS67987.1 - 2.1 8.3 6.6 1.4 8.9 0.1 3.2 3 0 0 3 3 3 0 Lecithin retinol acyltransferase MIF4G PF02854.14 ESS67988.1 - 1.1e-13 51.0 0.4 2.2e-13 50.0 0.3 1.5 1 0 0 1 1 1 1 MIF4G domain V-SNARE PF05008.10 ESS67988.1 - 0.56 10.3 4.6 0.23 11.6 0.3 2.5 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus NDK PF00334.14 ESS67989.1 - 9.6e-13 48.0 0.1 2.1e-07 30.8 0.0 2.5 2 0 0 2 2 2 2 Nucleoside diphosphate kinase PaREP1 PF05942.6 ESS67990.1 - 0.025 14.4 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family LsmAD PF06741.8 ESS67991.1 - 2.3e-26 91.6 0.8 5.5e-26 90.4 0.6 1.7 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.1 ESS67991.1 - 1.9e-16 59.7 0.0 3.5e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain TPR_2 PF07719.12 ESS67992.1 - 0.023 14.5 0.9 0.086 12.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS67992.1 - 0.035 13.7 0.0 0.081 12.5 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS67992.1 - 0.035 14.0 1.1 0.16 11.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Paf67 PF10255.4 ESS67992.1 - 0.092 11.6 0.2 0.17 10.7 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 zf-C3HC4_3 PF13920.1 ESS67993.1 - 6e-16 57.8 10.3 1e-15 57.1 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS67993.1 - 3.4e-09 36.5 13.8 6.2e-09 35.7 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS67993.1 - 0.00018 21.2 12.7 0.00018 21.2 8.8 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 ESS67993.1 - 0.00034 20.2 13.4 0.00059 19.4 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 ESS67993.1 - 0.0042 16.6 5.0 0.0089 15.5 3.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.1 ESS67993.1 - 0.015 14.9 11.4 0.027 14.1 7.9 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.1 ESS67993.1 - 0.23 11.0 8.6 0.42 10.2 6.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.9 ESS67993.1 - 0.75 9.3 10.4 1.7 8.2 7.2 1.5 1 0 0 1 1 1 0 P-11 zinc finger Trichoplein PF13868.1 ESS67994.1 - 6.7e-72 241.7 157.0 6.7e-72 241.7 108.8 2.0 2 0 0 2 2 2 1 Tumour suppressor, Mitostatin zf-C3HC4_3 PF13920.1 ESS67995.1 - 6.1e-11 41.8 11.7 6.1e-11 41.8 8.1 3.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Ras PF00071.17 ESS67996.1 - 4.9e-54 182.0 0.0 6.3e-54 181.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS67996.1 - 3.8e-16 59.6 0.0 8.2e-16 58.5 0.0 1.6 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 ESS67996.1 - 4.7e-09 35.7 0.0 6.4e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESS67996.1 - 7.5e-06 25.5 0.0 0.00017 21.0 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESS67996.1 - 2.5e-05 24.1 0.0 4.8e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESS67996.1 - 6.8e-05 22.1 0.0 9.7e-05 21.6 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_18 PF13238.1 ESS67996.1 - 7.4e-05 23.0 3.9 0.0026 18.0 0.0 2.9 3 1 0 3 3 3 1 AAA domain DUF258 PF03193.11 ESS67996.1 - 0.00074 18.7 0.0 0.016 14.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS67996.1 - 0.0013 18.7 0.0 0.0033 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.4 ESS67996.1 - 0.0042 16.5 0.0 0.032 13.7 0.0 2.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 ESS67996.1 - 0.023 13.9 0.0 0.06 12.5 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_17 PF13207.1 ESS67996.1 - 0.042 14.6 1.0 0.074 13.8 0.1 2.1 2 1 0 2 2 1 0 AAA domain Atrophin-1 PF03154.10 ESS67996.1 - 0.051 11.7 0.5 0.074 11.1 0.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family ABC_tran PF00005.22 ESS67996.1 - 0.064 13.5 0.2 0.25 11.6 0.0 2.1 2 1 0 2 2 1 0 ABC transporter AAA_24 PF13479.1 ESS67996.1 - 0.077 12.5 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sugar_tr PF00083.19 ESS67996.1 - 0.088 11.3 0.0 0.15 10.5 0.0 1.3 1 0 0 1 1 1 0 Sugar (and other) transporter ATP_bind_1 PF03029.12 ESS67996.1 - 0.16 11.4 0.1 1.2 8.6 0.1 2.1 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF755 PF05501.6 ESS67996.1 - 0.58 10.2 8.6 0.1 12.6 3.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF755) RIB43A PF05914.7 ESS67997.1 - 5.9e-101 337.8 59.6 7.2e-101 337.5 41.3 1.0 1 0 0 1 1 1 1 RIB43A Atx10homo_assoc PF09759.4 ESS68000.1 - 1.9e-31 107.8 0.0 3.7e-31 106.8 0.0 1.5 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Aa_trans PF01490.13 ESS68001.1 - 1.7e-55 188.1 29.3 2.1e-55 187.8 20.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 ESS68001.1 - 9.9e-07 27.6 6.6 9.9e-07 27.6 4.6 2.9 2 1 1 3 3 3 2 Amino acid permease ZZ PF00569.12 ESS68002.1 - 0.051 13.1 2.1 0.16 11.5 1.4 1.9 1 0 0 1 1 1 0 Zinc finger, ZZ type Prok-RING_2 PF14445.1 ESS68002.1 - 1.4 8.9 6.3 0.13 12.2 0.8 2.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 2 GAS PF13851.1 ESS68013.1 - 2.5e-67 226.0 32.2 2.5e-67 226.0 22.3 3.2 1 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding DUF3040 PF11239.3 ESS68013.1 - 0.18 11.8 1.8 0.83 9.7 1.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) She9_MDM33 PF05546.6 ESS68013.1 - 6.1 6.3 46.3 0.16 11.4 4.2 4.3 1 1 1 4 4 4 0 She9 / Mdm33 family PSD5 PF07637.6 ESS68013.1 - 9.4 6.3 9.5 1.8 8.6 1.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) Zn_ribbon_recom PF13408.1 ESS68014.1 - 0.11 12.7 0.5 0.22 11.7 0.3 1.4 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain CBF PF03914.12 ESS68016.1 - 7.5e-34 116.5 0.0 2.8e-33 114.7 0.0 2.0 2 0 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.6 ESS68016.1 - 0.027 14.7 0.1 0.027 14.7 0.0 3.0 3 0 0 3 3 3 0 Nucleolar complex-associated protein DUF607 PF04678.8 ESS68016.1 - 0.12 12.2 1.3 0.31 10.9 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Vault PF01505.13 ESS68017.1 - 7.7e-46 153.8 0.5 1.6e-14 53.6 0.0 5.9 6 0 0 6 6 6 4 Major Vault Protein repeat MVP_shoulder PF11978.3 ESS68017.1 - 0.0045 16.8 0.0 0.008 16.0 0.0 1.4 1 0 0 1 1 1 1 Shoulder domain RE_HindIII PF09518.5 ESS68018.1 - 0.14 11.0 6.7 0.38 9.6 1.6 2.2 2 0 0 2 2 2 0 HindIII restriction endonuclease DUF2465 PF10239.4 ESS68018.1 - 0.29 10.2 6.6 0.49 9.5 4.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2465) DUF3576 PF12100.3 ESS68018.1 - 0.61 10.1 5.6 0.14 12.1 0.6 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3576) Phage_Mu_Gam PF07352.7 ESS68018.1 - 6.3 6.3 11.6 0.085 12.3 2.5 1.9 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein Ribosomal_S5_C PF03719.10 ESS68019.1 - 9.2e-17 60.0 0.1 1.5e-16 59.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 ESS68019.1 - 0.018 14.7 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain DEAD PF00270.24 ESS68020.1 - 7.7e-46 155.6 0.5 4.4e-45 153.2 0.2 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS68020.1 - 9.5e-23 79.8 0.1 2.3e-22 78.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS68020.1 - 0.00044 20.1 0.1 0.0022 17.8 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESS68020.1 - 0.0015 17.3 0.0 0.0026 16.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 ESS68021.1 - 1.8e-37 128.4 0.0 3.3e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS68021.1 - 1.8e-17 62.9 0.0 3.9e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS68021.1 - 0.078 12.8 0.1 0.29 10.9 0.0 2.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Ras PF00071.17 ESS68023.1 - 8.2e-24 83.8 0.0 3.1e-23 81.9 0.0 1.8 2 0 0 2 2 2 1 Ras family Miro PF08477.8 ESS68023.1 - 1.6e-14 54.4 0.0 2.5e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 ESS68023.1 - 0.0095 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.18 ESS68023.1 - 0.022 14.6 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Arch_ATPase PF01637.13 ESS68023.1 - 0.044 13.4 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase AAA_22 PF13401.1 ESS68023.1 - 0.078 13.1 0.0 0.74 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESS68023.1 - 0.13 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 ESS68023.1 - 0.13 12.0 0.0 0.37 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Arf PF00025.16 ESS68023.1 - 0.14 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family G-alpha PF00503.15 ESS68023.1 - 0.21 10.2 0.1 0.46 9.0 0.0 1.5 1 1 0 1 1 1 0 G-protein alpha subunit MORN PF02493.15 ESS68024.1 - 4.5e-53 173.9 110.0 3.3e-07 29.6 2.0 18.3 20 1 0 20 20 20 14 MORN repeat Pyr_redox PF00070.22 ESS68025.1 - 8.3 6.8 6.7 96 3.4 0.1 3.9 3 1 1 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase XRN_N PF03159.13 ESS68026.1 - 5.2e-84 281.3 0.0 9.3e-84 280.5 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus TPR_11 PF13414.1 ESS68027.1 - 3e-30 103.6 2.8 3.7e-07 29.6 0.0 5.9 5 0 0 5 5 5 5 TPR repeat TPR_1 PF00515.23 ESS68027.1 - 4.6e-15 54.5 11.3 0.0016 17.9 0.0 8.9 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68027.1 - 4.8e-15 54.1 12.1 0.037 13.9 0.2 8.8 8 1 1 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68027.1 - 9.7e-12 45.0 7.7 0.059 13.7 0.0 7.1 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS68027.1 - 6e-10 38.9 9.5 0.0051 16.7 0.0 5.8 5 1 2 7 7 6 5 Tetratricopeptide repeat Apc3 PF12895.2 ESS68027.1 - 2.3e-09 37.2 9.5 0.087 12.9 0.3 6.0 4 3 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS68027.1 - 5.4e-09 35.8 13.9 0.3 11.8 0.0 8.3 5 3 3 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS68027.1 - 2.2e-07 30.1 4.7 0.027 14.2 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS68027.1 - 1.2e-06 28.1 0.9 4.1 7.8 0.0 6.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68027.1 - 2.3e-06 26.9 10.8 0.57 10.1 0.0 7.8 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS68027.1 - 3.3e-06 26.8 20.9 0.032 14.0 0.0 7.7 6 3 2 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68027.1 - 0.00021 21.8 14.8 1.4 9.6 0.6 6.7 6 3 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68027.1 - 0.013 15.9 9.9 6.7 7.4 0.5 6.0 7 0 0 7 7 4 0 Tetratricopeptide repeat NARP1 PF12569.3 ESS68027.1 - 0.014 14.1 0.0 3.2 6.3 0.1 3.2 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 RPN7 PF10602.4 ESS68027.1 - 0.028 13.7 0.9 1.8 7.8 0.0 3.4 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_10 PF13374.1 ESS68027.1 - 0.069 13.0 0.0 0.069 13.0 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF3654 PF12376.3 ESS68027.1 - 0.15 11.8 0.0 1.8 8.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3654) Aldedh PF00171.17 ESS68028.1 - 4.7e-159 529.6 0.0 5.4e-159 529.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 ESS68028.1 - 0.004 15.9 0.0 0.0062 15.3 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.6 ESS68028.1 - 0.063 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Lactonase PF10282.4 ESS68029.1 - 0.0012 17.9 0.5 0.094 11.7 0.0 3.0 3 1 0 3 3 3 2 Lactonase, 7-bladed beta-propeller Sec34 PF04136.10 ESS68031.1 - 1.3e-12 47.7 0.7 6.5e-12 45.4 0.3 2.4 2 0 0 2 2 2 1 Sec34-like family POX PF07526.6 ESS68031.1 - 2.4 8.3 13.1 0.78 9.9 4.2 3.4 3 1 0 3 3 3 0 Associated with HOX Beach PF02138.13 ESS68032.1 - 5.4e-103 344.1 0.0 8.9e-103 343.4 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 ESS68032.1 - 4.5e-11 42.5 0.0 9.5e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 ESS68032.1 - 2.6e-09 36.6 1.1 0.026 14.3 0.0 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat Laminin_G_3 PF13385.1 ESS68032.1 - 4.2e-09 36.8 0.0 1.1e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GPI2 PF06432.6 ESS68033.1 - 1.5e-76 257.4 8.6 1.8e-76 257.2 6.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Peptidase_M76 PF09768.4 ESS68035.1 - 2.3e-59 199.7 0.2 2.8e-59 199.4 0.1 1.0 1 0 0 1 1 1 1 Peptidase M76 family Tox-MPTase2 PF15638.1 ESS68035.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 HTH_30 PF13556.1 ESS68035.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Tox-MPTase3 PF15639.1 ESS68035.1 - 0.15 11.7 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Metallopeptidase toxin 3 S4 PF01479.20 ESS68037.1 - 3e-07 29.7 0.5 4.9e-05 22.6 0.0 2.5 2 0 0 2 2 2 2 S4 domain PseudoU_synth_2 PF00849.17 ESS68037.1 - 2.5e-05 24.1 0.0 4.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase Proteasome PF00227.21 ESS68038.1 - 1.1e-50 171.5 0.3 1.4e-50 171.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Clathrin PF00637.15 ESS68039.1 - 1.5e-165 543.3 33.1 5.4e-28 97.3 0.6 8.3 8 0 0 8 8 8 8 Region in Clathrin and VPS Clathrin_propel PF01394.15 ESS68039.1 - 3.5e-21 73.9 0.1 0.015 15.5 0.1 7.5 7 0 0 7 7 7 4 Clathrin propeller repeat Clathrin_H_link PF13838.1 ESS68039.1 - 1.6e-20 72.7 0.0 1.5e-19 69.6 0.0 2.7 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.5 ESS68039.1 - 1.9e-11 42.7 0.0 7.2e-11 40.8 0.0 2.1 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_1 PF00515.23 ESS68039.1 - 4.7e-06 25.9 1.1 16 5.2 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68039.1 - 2.8e-05 23.6 1.1 42 4.4 0.0 6.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68039.1 - 0.00035 20.9 8.9 84 4.2 0.0 8.4 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68039.1 - 0.00088 18.8 0.0 20 5.2 0.0 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat HCNGP PF07818.8 ESS68039.1 - 0.027 14.5 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 0 HCNGP-like protein Coatomer_WDAD PF04053.9 ESS68039.1 - 0.032 13.0 7.2 0.5 9.0 0.1 3.6 4 0 0 4 4 4 0 Coatomer WD associated region Proteasome PF00227.21 ESS68040.1 - 5.4e-54 182.3 0.0 6.6e-54 182.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESS68040.1 - 1.2e-13 50.1 0.0 2.5e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature STAG PF08514.6 ESS68041.1 - 1.6e-15 56.8 0.1 6.8e-15 54.8 0.0 2.1 2 0 0 2 2 2 1 STAG domain 6PGD PF00393.14 ESS68043.1 - 0.086 12.0 0.1 0.086 12.0 0.0 1.9 2 1 0 2 2 2 0 6-phosphogluconate dehydrogenase, C-terminal domain IFT57 PF10498.4 ESS68043.1 - 0.15 10.7 27.7 0.078 11.7 13.7 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 MAD PF05557.8 ESS68043.1 - 0.58 8.1 32.4 0.052 11.6 15.6 2.2 2 0 0 2 2 2 0 Mitotic checkpoint protein Baculo_PEP_C PF04513.7 ESS68043.1 - 0.77 9.5 10.0 0.05 13.4 0.6 3.0 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_TATA_bd PF12325.3 ESS68043.1 - 0.86 9.3 37.7 1 9.1 9.1 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.3 ESS68043.1 - 3.2 4.9 36.6 0.079 10.2 16.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Mit_KHE1 PF10173.4 ESS68043.1 - 6.3 6.6 7.7 11 5.8 3.6 2.2 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related LRR_4 PF12799.2 ESS68044.1 - 1.5e-23 81.9 30.0 8.4e-07 28.4 1.6 5.8 3 1 5 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS68044.1 - 2.6e-16 59.0 25.6 1.2e-06 28.1 2.7 5.1 4 1 0 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 ESS68044.1 - 3e-08 32.6 30.5 0.24 11.5 0.4 9.3 9 1 0 9 9 9 4 Leucine Rich Repeat LRR_9 PF14580.1 ESS68044.1 - 1.6e-07 31.0 8.9 0.043 13.3 0.1 4.3 2 1 2 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.1 ESS68044.1 - 5.3e-06 25.9 26.5 0.58 10.3 0.6 8.6 7 2 1 8 8 8 3 Leucine Rich repeat LRR_7 PF13504.1 ESS68044.1 - 0.00073 19.3 30.6 7.8 7.1 0.6 8.8 9 0 0 9 9 9 3 Leucine rich repeat LRR_5 PF13306.1 ESS68044.1 - 0.013 15.2 0.5 0.037 13.7 0.3 1.8 2 0 0 2 2 2 0 Leucine rich repeats (6 copies) DUF1647 PF07801.6 ESS68044.1 - 0.72 9.3 3.2 11 5.5 0.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1647) ELMO_CED12 PF04727.8 ESS68045.1 - 2.5e-38 131.2 0.0 3.7e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family Pkinase PF00069.20 ESS68046.1 - 1.2e-46 158.9 0.0 2.1e-46 158.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68046.1 - 1.6e-34 119.1 0.0 2.9e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68046.1 - 4.6e-06 25.7 0.0 1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PH PF00169.24 ESS68046.1 - 7e-05 22.9 0.1 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 ESS68046.1 - 0.00084 19.4 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 ESS68046.1 - 0.098 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.20 ESS68047.1 - 2.7e-56 190.6 0.0 3.8e-56 190.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68047.1 - 2.4e-36 125.1 0.0 3.9e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68047.1 - 5.3e-07 28.8 0.0 4.1e-06 25.9 0.0 1.9 1 1 1 2 2 2 1 Kinase-like PH PF00169.24 ESS68047.1 - 6.9e-06 26.2 0.0 4.9e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 PH domain PH_9 PF15410.1 ESS68047.1 - 0.0044 17.1 0.0 0.018 15.1 0.0 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_4 PF15404.1 ESS68047.1 - 0.055 13.0 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain XRN_N PF03159.13 ESS68048.1 - 0.0007 19.0 0.0 0.021 14.2 0.0 2.6 3 0 0 3 3 3 2 XRN 5'-3' exonuclease N-terminus Kelch_3 PF13415.1 ESS68051.1 - 1.8e-14 53.4 0.1 2.4e-06 27.5 0.0 4.4 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESS68051.1 - 3.1e-14 52.4 0.2 2.2e-06 27.3 0.0 4.6 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS68051.1 - 8.7e-13 47.9 1.7 0.0016 18.3 0.0 3.8 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 ESS68051.1 - 2.1e-10 39.9 1.2 2.6e-05 23.7 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 ESS68051.1 - 4.6e-10 39.2 0.3 0.0052 16.9 0.1 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 ESS68051.1 - 2.6e-07 30.0 4.2 0.014 14.9 0.4 3.7 4 0 0 4 4 4 2 Kelch motif EF-hand_8 PF13833.1 ESS68054.1 - 0.018 14.6 0.0 2.5 7.7 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair FumaraseC_C PF10415.4 ESS68054.1 - 0.07 13.2 0.7 0.91 9.6 0.1 2.5 3 0 0 3 3 3 0 Fumarase C C-terminus DUF563 PF04577.9 ESS68058.1 - 1.5e-14 54.4 0.4 2.3e-14 53.7 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) zf-RanBP PF00641.13 ESS68059.1 - 2.1e-15 55.4 96.1 3.8e-06 25.9 1.0 9.8 10 0 0 10 10 10 9 Zn-finger in Ran binding protein and others DZR PF12773.2 ESS68059.1 - 1.4e-14 53.6 71.2 0.0003 20.5 7.0 6.8 5 1 2 7 7 7 7 Double zinc ribbon DZR PF12773.2 ESS68060.1 - 1.9e-07 30.7 155.2 0.012 15.3 11.4 12.5 5 2 10 15 15 15 13 Double zinc ribbon zf-RanBP PF00641.13 ESS68060.1 - 0.0043 16.1 7.6 0.0058 15.7 2.7 17.9 15 2 3 18 18 18 11 Zn-finger in Ran binding protein and others ARL2_Bind_BART PF11527.3 ESS68061.1 - 2e-34 117.9 0.0 4e-34 117.0 0.0 1.5 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART UIM PF02809.15 ESS68061.1 - 0.014 14.8 3.0 0.014 14.8 2.1 3.1 2 0 0 2 2 2 0 Ubiquitin interaction motif TPR_MLP1_2 PF07926.7 ESS68062.1 - 0.013 15.2 2.6 0.049 13.3 1.6 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.3 ESS68062.1 - 0.17 11.6 3.9 0.41 10.4 2.7 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESS68062.1 - 1.2 8.6 5.0 2.2 7.8 3.5 1.4 1 0 0 1 1 1 0 IncA protein Trypsin_2 PF13365.1 ESS68063.1 - 6.6e-06 26.1 0.0 1.3e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Atx10homo_assoc PF09759.4 ESS68063.1 - 0.017 14.8 0.0 0.045 13.4 0.0 1.7 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain HisKA_2 PF07568.7 ESS68063.1 - 0.032 14.0 0.0 0.083 12.7 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase Aa_trans PF01490.13 ESS68064.1 - 3.8e-44 150.8 31.4 4.9e-44 150.4 21.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Herpes_US12 PF05363.7 ESS68064.1 - 0.11 13.0 0.1 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus US12 family AAA PF00004.24 ESS68065.1 - 2.6e-78 260.6 0.1 2.7e-47 160.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 ESS68065.1 - 8e-22 76.9 0.2 2.3e-21 75.4 0.1 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.12 ESS68065.1 - 2.9e-10 39.6 0.0 7.4e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.9 ESS68065.1 - 6.1e-08 32.7 3.4 2.9e-06 27.2 0.0 2.9 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESS68065.1 - 5.2e-07 29.8 0.0 3.1e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESS68065.1 - 2.1e-06 28.5 0.0 4.5e-05 24.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 ESS68065.1 - 3e-06 27.1 0.0 9.3e-06 25.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS68065.1 - 3.1e-06 26.9 0.4 5.7e-05 22.8 0.0 3.1 3 2 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS68065.1 - 3.4e-06 27.2 0.1 0.001 19.2 0.0 3.5 3 1 0 3 3 2 1 AAA domain RuvB_N PF05496.7 ESS68065.1 - 3.7e-06 26.1 0.0 9.6e-06 24.8 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESS68065.1 - 0.00017 21.5 0.0 0.001 19.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESS68065.1 - 0.00019 20.2 0.0 0.00037 19.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus ResIII PF04851.10 ESS68065.1 - 0.00025 20.9 0.8 0.005 16.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Vps4_C PF09336.5 ESS68065.1 - 0.00069 19.4 0.0 0.0027 17.5 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_25 PF13481.1 ESS68065.1 - 0.0015 18.0 2.8 2.3 7.5 0.0 3.4 2 1 0 3 3 3 2 AAA domain Zeta_toxin PF06414.7 ESS68065.1 - 0.0022 17.1 0.0 0.0048 16.0 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 ESS68065.1 - 0.0061 16.8 0.0 0.0061 16.8 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.1 ESS68065.1 - 0.01 15.5 0.2 0.029 14.0 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 ESS68065.1 - 0.017 14.5 0.0 0.048 13.0 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESS68065.1 - 0.018 14.1 0.0 0.044 12.9 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Arch_ATPase PF01637.13 ESS68065.1 - 0.018 14.7 2.3 0.13 11.8 0.1 2.9 2 1 1 3 3 3 0 Archaeal ATPase Molydop_binding PF01568.16 ESS68065.1 - 0.019 14.7 0.0 0.053 13.3 0.0 1.8 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain KaiC PF06745.8 ESS68065.1 - 0.021 13.9 1.6 1.3 8.1 0.0 2.7 2 1 1 3 3 3 0 KaiC Sigma54_activat PF00158.21 ESS68065.1 - 0.023 14.1 0.0 0.087 12.2 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 ESS68065.1 - 0.026 14.5 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 ESS68065.1 - 0.035 14.0 0.0 0.18 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESS68065.1 - 0.087 13.0 0.0 0.34 11.0 0.0 2.1 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 ESS68065.1 - 0.12 12.0 0.0 2.1 7.9 0.0 2.6 3 0 0 3 3 3 0 NACHT domain ADK PF00406.17 ESS68066.1 - 3.9e-39 133.9 0.0 5.1e-39 133.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 ESS68066.1 - 3.5e-08 34.2 0.0 8.2e-08 33.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESS68066.1 - 4.6e-07 30.1 0.1 9.7e-07 29.1 0.0 1.5 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.9 ESS68066.1 - 0.00016 21.2 0.0 0.00034 20.2 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 ESS68066.1 - 0.00061 19.6 0.0 0.0014 18.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESS68066.1 - 0.0012 17.9 0.0 0.0044 16.1 0.0 1.9 1 1 0 1 1 1 1 Zeta toxin AAA_28 PF13521.1 ESS68066.1 - 0.0066 16.4 0.0 0.043 13.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 ESS68066.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-RING_2 PF13639.1 ESS68067.1 - 1.1e-12 47.5 8.6 1.6e-12 47.0 5.9 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS68067.1 - 9.6e-12 44.7 7.5 1.4e-11 44.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS68067.1 - 4e-10 39.1 5.1 5.9e-10 38.6 3.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS68067.1 - 1.1e-09 37.8 3.6 1.5e-09 37.3 2.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESS68067.1 - 2.3e-08 33.7 6.9 1e-07 31.6 4.7 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 ESS68067.1 - 4.3e-08 32.7 4.8 6.7e-08 32.1 3.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESS68067.1 - 4.8e-08 32.5 1.4 1.4e-07 31.1 0.2 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESS68067.1 - 0.00021 20.9 3.5 0.00041 20.0 2.4 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.1 ESS68067.1 - 0.00037 19.9 4.0 0.00071 19.0 2.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Apc11 PF12861.2 ESS68067.1 - 0.00048 19.9 1.6 0.00082 19.1 1.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESS68067.1 - 0.0014 18.7 8.5 0.0042 17.1 5.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Nse PF11789.3 ESS68067.1 - 0.034 13.6 1.4 0.051 13.0 0.9 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Baculo_IE-1 PF05290.6 ESS68067.1 - 0.11 12.1 2.0 0.17 11.6 1.4 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) MSA-2c PF12238.3 ESS68067.1 - 0.36 10.4 1.9 0.55 9.8 1.3 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c zf-RING_4 PF14570.1 ESS68067.1 - 0.45 10.1 7.1 1.4 8.5 5.0 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-MIZ PF02891.15 ESS68067.1 - 0.69 9.4 5.2 1.2 8.7 3.6 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger IBR PF01485.16 ESS68067.1 - 1.6 8.6 7.8 4.9 7.0 5.5 1.8 1 1 0 1 1 1 0 IBR domain zf-CCHC PF00098.18 ESS68068.1 - 2e-61 201.1 58.2 3.1e-09 36.3 1.0 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.1 ESS68068.1 - 3.7e-19 68.1 40.9 0.0014 18.2 0.4 7.1 2 2 5 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 ESS68068.1 - 7.6e-15 54.3 42.1 0.00068 19.2 0.4 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_2 PF13696.1 ESS68068.1 - 4.7e-12 45.1 47.5 0.00034 20.0 1.0 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_6 PF15288.1 ESS68068.1 - 0.038 13.6 56.3 0.36 10.5 1.6 7.1 7 0 0 7 7 7 0 Zinc knuckle eIF3g PF12353.3 ESS68068.1 - 5.7 6.8 34.8 4.9 7.0 0.1 6.9 7 0 0 7 7 7 0 Eukaryotic translation initiation factor 3 subunit G PLAC8 PF04749.12 ESS68069.1 - 3.1e-12 46.9 24.3 3.1e-12 46.9 16.8 1.4 2 0 0 2 2 2 1 PLAC8 family DUF778 PF05608.7 ESS68071.1 - 4.7e-43 146.3 0.0 5.6e-43 146.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF778) UCR_hinge PF02320.11 ESS68071.1 - 0.14 12.0 2.7 0.3 11.0 1.8 1.6 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein DUF746 PF05344.6 ESS68072.1 - 0.012 15.1 0.0 0.031 13.8 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) Laminin_II PF06009.7 ESS68072.1 - 0.074 12.8 0.6 1.7 8.4 0.1 2.0 1 1 1 2 2 2 0 Laminin Domain II DUF4061 PF13270.1 ESS68072.1 - 0.094 12.8 2.4 0.13 12.3 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) DUF4398 PF14346.1 ESS68072.1 - 0.12 12.3 4.3 0.066 13.2 1.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) Ribosomal_L37ae PF01780.14 ESS68073.1 - 3.3e-36 123.0 4.9 3.6e-36 122.9 3.4 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family C1_1 PF00130.17 ESS68073.1 - 0.0025 17.5 2.1 0.0036 16.9 1.5 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.5 ESS68073.1 - 0.0076 15.6 0.5 2.5 7.6 0.0 2.1 2 0 0 2 2 2 2 A2L zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 ESS68073.1 - 0.099 12.4 2.4 0.16 11.8 1.7 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain NOB1_Zn_bind PF08772.6 ESS68073.1 - 0.13 12.1 3.8 1.5 8.6 2.7 2.2 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Carla_C4 PF01623.12 ESS68073.1 - 0.13 12.0 1.7 0.16 11.7 1.1 1.4 1 1 0 1 1 1 0 Carlavirus putative nucleic acid binding protein zf-HIT PF04438.11 ESS68073.1 - 0.2 11.3 2.5 0.24 11.0 0.3 1.9 2 0 0 2 2 2 0 HIT zinc finger GFA PF04828.9 ESS68073.1 - 0.27 11.1 2.8 3.4 7.6 1.9 2.1 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme zf-C4_ClpX PF06689.8 ESS68073.1 - 6.8 6.2 6.6 1.3 8.5 1.9 1.8 2 0 0 2 2 2 0 ClpX C4-type zinc finger zf-CCHC PF00098.18 ESS68074.1 - 5.4e-51 168.2 64.3 3e-08 33.2 1.3 8.1 8 0 0 8 8 8 8 Zinc knuckle zf-CCHC_4 PF14392.1 ESS68074.1 - 5.5e-16 57.9 49.8 0.0024 17.5 0.3 8.1 8 0 0 8 8 8 8 Zinc knuckle zf-CCHC_2 PF13696.1 ESS68074.1 - 1.7e-09 36.9 51.5 0.011 15.1 0.3 8.1 1 1 7 8 8 8 7 Zinc knuckle zf-CCHC_3 PF13917.1 ESS68074.1 - 7.5e-06 25.5 45.4 0.15 11.8 0.3 7.6 2 2 5 7 7 7 6 Zinc knuckle zf-CCHC_5 PF14787.1 ESS68074.1 - 0.00093 18.6 6.7 0.0043 16.5 1.3 7.8 6 1 2 8 8 8 5 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.1 ESS68074.1 - 0.0064 16.1 1.9 0.0064 16.1 1.3 7.5 7 1 1 8 8 8 3 Zinc knuckle RMF PF04957.7 ESS68074.1 - 2.6 7.7 10.4 0.21 11.3 0.4 3.6 2 1 3 5 5 5 0 Ribosome modulation factor Tmemb_9 PF05434.6 ESS68076.1 - 9 6.0 8.2 0.27 10.9 0.1 2.2 2 1 1 3 3 3 0 TMEM9 Nt_Gln_amidase PF09764.4 ESS68077.1 - 1.1e-64 217.0 0.2 1.4e-64 216.7 0.1 1.1 1 0 0 1 1 1 1 N-terminal glutamine amidase KfrA_N PF11740.3 ESS68077.1 - 0.16 12.4 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term zf-CCHC PF00098.18 ESS68078.1 - 1.6e-43 144.5 38.9 1.8e-09 37.0 1.0 5.1 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_4 PF14392.1 ESS68078.1 - 1.6e-16 59.6 26.1 0.00031 20.3 0.4 5.1 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_3 PF13917.1 ESS68078.1 - 3.2e-12 45.9 27.5 0.0036 17.0 0.2 5.1 2 2 3 5 5 5 5 Zinc knuckle zf-CCHC_2 PF13696.1 ESS68078.1 - 1.1e-09 37.6 27.6 0.0002 20.7 1.0 5.2 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_6 PF15288.1 ESS68078.1 - 0.00054 19.5 39.6 0.089 12.4 1.1 5.1 5 0 0 5 5 5 4 Zinc knuckle DZR PF12773.2 ESS68078.1 - 0.36 10.6 29.1 1.5e+04 -10.0 20.2 4.1 1 1 0 1 1 1 0 Double zinc ribbon PLAC8 PF04749.12 ESS68079.1 - 7e-12 45.8 24.4 7e-12 45.8 16.9 1.9 2 0 0 2 2 2 1 PLAC8 family Amastin PF07344.6 ESS68094.1 - 1.4e-27 96.2 29.2 8.1e-16 58.0 8.3 2.1 2 0 0 2 2 2 2 Amastin surface glycoprotein Methyltransf_16 PF10294.4 ESS68095.1 - 1.2e-08 34.6 0.0 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_18 PF12847.2 ESS68095.1 - 7e-05 23.3 0.0 0.0001 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESS68095.1 - 0.00073 18.7 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 ESS68095.1 - 0.0028 17.9 0.0 0.005 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS68095.1 - 0.15 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain FAD_binding_3 PF01494.14 ESS68096.1 - 1.3e-06 27.7 0.3 0.36 9.8 0.0 3.2 3 0 0 3 3 3 3 FAD binding domain DAO PF01266.19 ESS68096.1 - 0.0026 16.7 0.0 0.008 15.1 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase 3HCDH_N PF02737.13 ESS68096.1 - 0.0078 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 ESS68096.1 - 0.061 13.7 0.1 0.17 12.3 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS68096.1 - 0.098 12.6 0.2 0.33 11.0 0.2 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESS68096.1 - 0.1 11.6 0.1 0.2 10.7 0.1 1.4 1 0 0 1 1 1 0 Thi4 family UDPG_MGDP_dh_N PF03721.9 ESS68096.1 - 0.23 10.8 0.0 0.44 9.9 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PPR_3 PF13812.1 ESS68098.1 - 0.0011 19.1 0.0 0.064 13.5 0.0 3.0 2 0 0 2 2 2 1 Pentatricopeptide repeat domain DUF1517 PF07466.6 ESS68098.1 - 0.11 11.4 0.7 11 4.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1517) PPR_3 PF13812.1 ESS68099.1 - 0.0082 16.3 0.0 0.055 13.7 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain MTBP_C PF14920.1 ESS68099.1 - 0.083 12.3 1.8 0.13 11.7 1.3 1.3 1 0 0 1 1 1 0 MDM2-binding CwfJ_C_1 PF04677.10 ESS68099.1 - 0.15 11.7 0.3 6.6 6.4 0.0 2.2 1 1 1 2 2 2 0 Protein similar to CwfJ C-terminus 1 F-box-like PF12937.2 ESS68100.1 - 0.01 15.5 0.3 0.022 14.4 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESS68100.1 - 0.014 15.0 0.2 0.05 13.2 0.1 2.0 1 0 0 1 1 1 0 F-box domain tRNA-synt_2c PF01411.14 ESS68101.1 - 1.3e-07 30.2 0.0 1.8e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 ESS68101.1 - 5.9e-07 29.2 0.3 1.2e-06 28.3 0.2 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Cmc1 PF08583.5 ESS68102.1 - 0.00076 19.1 3.1 0.0023 17.6 2.1 1.8 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Med15_fungi PF05397.7 ESS68102.1 - 0.0099 15.8 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 Mediator complex subunit 15 Menin PF05053.8 ESS68102.1 - 0.16 10.0 2.5 0.19 9.8 1.7 1.1 1 0 0 1 1 1 0 Menin TfoX_N PF04993.8 ESS68102.1 - 0.41 10.5 2.1 0.46 10.3 0.1 2.0 2 1 1 3 3 3 0 TfoX N-terminal domain Papo_T_antigen PF02380.10 ESS68102.1 - 0.49 10.3 4.3 0.18 11.7 0.8 1.8 2 0 0 2 2 2 0 T-antigen specific domain LHH PF14411.1 ESS68102.1 - 0.52 10.5 3.5 16 5.7 0.2 2.4 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH UPF0203 PF05254.7 ESS68102.1 - 3.2 7.6 7.9 0.29 10.9 1.3 2.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0203) Snurportin1 PF11538.3 ESS68102.1 - 3.6 7.4 6.9 11 5.9 0.4 3.6 2 1 0 2 2 2 0 Snurportin1 Ipi1_N PF12333.3 ESS68103.1 - 2.4e-06 27.4 1.9 0.033 14.1 1.1 3.7 2 1 1 3 3 3 2 Rix1 complex component involved in 60S ribosome maturation HEAT PF02985.17 ESS68103.1 - 0.084 12.9 0.1 0.43 10.7 0.1 2.3 1 0 0 1 1 1 0 HEAT repeat Pkinase PF00069.20 ESS68104.1 - 3.2e-27 95.3 0.0 6.4e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68104.1 - 9.3e-12 44.5 0.0 1.3e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68104.1 - 0.027 13.4 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF3987 PF13148.1 ESS68104.1 - 0.84 8.1 4.8 1.3 7.4 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) TIMELESS PF04821.9 ESS68104.1 - 1.1 8.4 2.7 2.2 7.4 1.9 1.4 1 0 0 1 1 1 0 Timeless protein ABC_tran PF00005.22 ESS68105.1 - 2.8e-56 189.6 0.0 7.5e-27 94.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 ESS68105.1 - 8.6e-38 130.2 53.1 3.8e-32 111.6 15.3 2.4 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 ESS68105.1 - 8.8e-22 78.4 0.1 5.7e-08 33.0 0.0 4.3 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 ESS68105.1 - 1.6e-06 27.5 0.0 1.1 8.3 0.0 3.6 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESS68105.1 - 2.7e-06 27.8 0.1 0.044 14.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESS68105.1 - 8.9e-06 25.1 0.0 0.033 13.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.1 ESS68105.1 - 2.1e-05 24.3 0.0 0.062 13.2 0.0 3.4 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit DUF258 PF03193.11 ESS68105.1 - 5.4e-05 22.4 0.0 0.036 13.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_15 PF13175.1 ESS68105.1 - 0.00028 20.0 0.0 0.13 11.2 0.0 3.2 4 0 0 4 4 4 1 AAA ATPase domain SRP54 PF00448.17 ESS68105.1 - 0.0034 16.8 0.1 0.93 8.8 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_10 PF12846.2 ESS68105.1 - 0.0065 15.9 0.0 0.91 8.9 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain AAA_28 PF13521.1 ESS68105.1 - 0.012 15.5 0.1 3.3 7.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 ESS68105.1 - 0.016 14.6 0.2 2.6 7.4 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.1 ESS68105.1 - 0.023 14.5 0.4 8 6.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.1 ESS68105.1 - 0.032 13.8 0.0 2.2 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESS68105.1 - 0.065 13.4 0.1 11 6.2 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 ESS68105.1 - 0.16 11.9 0.1 3 7.8 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.1 ESS68105.1 - 0.19 12.5 0.2 11 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESS68105.1 - 0.21 11.2 0.1 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF4407 PF14362.1 ESS68105.1 - 0.34 9.8 1.4 0.7 8.7 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zeta_toxin PF06414.7 ESS68105.1 - 0.35 9.9 0.0 3.8 6.5 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_13 PF13166.1 ESS68105.1 - 0.55 8.6 0.1 11 4.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Pox_A_type_inc PF04508.7 ESS68109.1 - 0.058 13.1 4.0 0.086 12.6 0.0 3.4 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat AAA_23 PF13476.1 ESS68110.1 - 0.11 12.7 12.1 0.69 10.2 0.7 3.4 3 0 0 3 3 3 0 AAA domain SPX PF03105.14 ESS68110.1 - 4.4 7.0 18.8 1.2e+02 2.2 13.0 2.2 1 1 0 1 1 1 0 SPX domain Pex16 PF08610.5 ESS68111.1 - 1e-46 159.5 0.0 9e-46 156.3 0.0 1.9 2 0 0 2 2 2 1 Peroxisomal membrane protein (Pex16) GDI PF00996.13 ESS68112.1 - 3.1e-20 71.9 0.0 1.5e-10 39.9 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor Methyltransf_16 PF10294.4 ESS68113.1 - 7.3e-14 51.5 0.0 6.7e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_18 PF12847.2 ESS68113.1 - 5.7e-05 23.6 0.0 0.00018 22.0 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESS68113.1 - 0.0019 17.3 0.0 0.0039 16.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NNMT_PNMT_TEMT PF01234.12 ESS68113.1 - 0.0034 16.3 0.0 0.0056 15.6 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family MTS PF05175.9 ESS68113.1 - 0.077 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain FliJ PF02050.11 ESS68114.1 - 0.00023 21.2 16.8 0.00023 21.2 11.7 5.1 2 2 2 4 4 4 1 Flagellar FliJ protein SlyX PF04102.7 ESS68114.1 - 0.023 15.0 3.5 0.023 15.0 2.4 6.2 3 3 3 6 6 6 0 SlyX AAA_13 PF13166.1 ESS68114.1 - 0.048 12.1 36.8 0.3 9.5 9.1 2.4 2 0 0 2 2 2 0 AAA domain NFRKB_winged PF14465.1 ESS68114.1 - 0.056 13.2 0.7 29 4.5 0.0 3.5 3 0 0 3 3 3 0 NFRKB Winged Helix-like TEX12 PF15219.1 ESS68114.1 - 0.099 12.6 4.9 0.056 13.4 1.0 2.5 2 0 0 2 2 2 0 Testis-expressed 12 ATG16 PF08614.6 ESS68114.1 - 9 6.0 60.8 0.015 15.1 8.1 5.0 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) Nuc_sug_transp PF04142.10 ESS68115.1 - 2.2e-30 105.5 17.9 2.2e-30 105.5 12.4 2.3 2 1 0 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 ESS68115.1 - 1.9e-10 40.8 29.9 2.5e-06 27.5 7.7 2.6 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 ESS68115.1 - 0.00073 19.2 25.0 0.022 14.4 8.2 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family EmrE PF13536.1 ESS68115.1 - 0.023 14.8 22.1 0.42 10.8 4.1 2.8 2 1 0 2 2 2 0 Multidrug resistance efflux transporter MFS_1 PF07690.11 ESS68118.1 - 2.7e-16 59.2 22.4 6.3e-08 31.7 8.1 2.8 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.1 ESS68118.1 - 0.00015 20.2 23.5 0.00096 17.6 1.6 3.0 2 1 1 3 3 3 3 MFS/sugar transport protein MFS_1 PF07690.11 ESS68119.1 - 6e-06 25.1 0.5 7.2e-06 24.9 0.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESS68119.1 - 0.00092 17.9 7.7 0.0012 17.5 5.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Inositol_P PF00459.20 ESS68120.1 - 9.1e-52 176.0 0.1 2.2e-51 174.7 0.1 1.6 1 1 0 1 1 1 1 Inositol monophosphatase family SAP18 PF06487.7 ESS68121.1 - 0.0078 15.9 0.0 0.022 14.5 0.0 1.7 2 0 0 2 2 2 1 Sin3 associated polypeptide p18 (SAP18) Ribosomal_60s PF00428.14 ESS68121.1 - 4.9 7.6 7.4 13 6.2 0.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein ABC2_membrane PF01061.19 ESS68122.1 - 6.5e-35 120.2 24.8 6.5e-35 120.2 17.2 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESS68122.1 - 2.8e-19 69.7 0.0 4.3e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS68122.1 - 0.0013 18.7 0.1 0.87 9.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESS68122.1 - 0.0039 16.4 0.0 0.0064 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 NB-ARC PF00931.17 ESS68122.1 - 0.0048 15.8 0.0 0.0077 15.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_15 PF13175.1 ESS68122.1 - 0.011 14.7 0.0 0.78 8.7 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain SMC_N PF02463.14 ESS68122.1 - 0.014 14.6 0.1 0.084 12.0 0.0 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESS68122.1 - 0.015 14.8 1.0 0.03 13.8 0.7 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 ESS68122.1 - 0.016 15.5 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESS68122.1 - 0.022 14.8 0.3 0.057 13.5 0.1 1.8 2 0 0 2 2 1 0 AAA domain ABC2_membrane_2 PF12679.2 ESS68122.1 - 0.027 13.3 4.6 0.047 12.5 3.2 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein PRK PF00485.13 ESS68122.1 - 0.033 13.7 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 ESS68122.1 - 0.035 14.9 0.0 0.071 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESS68122.1 - 0.036 13.8 0.3 0.11 12.2 0.2 1.8 1 0 0 1 1 1 0 Part of AAA domain NTPase_1 PF03266.10 ESS68122.1 - 0.041 13.5 0.1 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.1 ESS68122.1 - 0.043 13.2 0.0 0.18 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESS68122.1 - 0.054 13.4 0.2 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 ESS68122.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 ESS68122.1 - 0.064 13.1 0.0 0.35 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESS68122.1 - 0.088 12.2 0.5 0.17 11.2 0.3 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.1 ESS68122.1 - 0.1 12.1 0.4 0.19 11.3 0.3 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 ESS68122.1 - 0.14 11.5 0.1 0.24 10.8 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain UPF0079 PF02367.12 ESS68122.1 - 0.16 11.6 0.2 0.38 10.3 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF87 PF01935.12 ESS68122.1 - 0.18 11.5 0.9 0.32 10.7 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA PF00004.24 ESS68122.1 - 0.2 11.8 0.1 0.79 9.9 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 ESS68122.1 - 0.21 10.2 0.0 0.32 9.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 ESS68122.1 - 0.45 10.0 0.9 0.76 9.3 0.6 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.2 ESS68122.1 - 2.5 7.0 19.4 0.055 12.4 8.9 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein ATP-gua_Ptrans PF00217.14 ESS68123.1 - 1.2e-107 358.7 0.0 2e-107 358.0 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.10 ESS68123.1 - 5.8e-35 119.2 0.5 1.4e-34 118.0 0.1 1.9 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, N-terminal domain HEAT_2 PF13646.1 ESS68126.1 - 3.7e-19 68.7 4.2 0.0017 18.6 0.0 6.4 2 2 3 6 6 6 5 HEAT repeats HEAT PF02985.17 ESS68126.1 - 3.4e-15 54.7 25.1 0.025 14.6 0.0 10.8 11 0 0 11 11 11 6 HEAT repeat Adaptin_N PF01602.15 ESS68126.1 - 1.8e-06 26.5 4.0 0.03 12.6 0.1 3.8 3 1 0 4 4 4 3 Adaptin N terminal region HEAT_EZ PF13513.1 ESS68126.1 - 0.00068 20.0 13.6 2.5 8.7 0.2 8.0 7 3 3 10 10 10 2 HEAT-like repeat Thia_YuaJ PF09515.5 ESS68126.1 - 0.046 13.4 0.1 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 Thiamine transporter protein (Thia_YuaJ) EF-hand_7 PF13499.1 ESS68127.1 - 8.5e-10 38.6 0.2 1.6e-05 24.9 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 ESS68127.1 - 1e-07 31.7 0.0 0.003 17.4 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain EF-hand_6 PF13405.1 ESS68127.1 - 1.8e-07 30.4 0.3 0.037 13.9 0.0 3.9 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 ESS68127.1 - 3.9e-07 29.5 0.1 0.0012 18.4 0.0 3.4 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS68127.1 - 2.6e-05 23.1 0.1 0.41 10.0 0.0 3.9 5 0 0 5 5 5 2 EF hand DUF2087 PF09860.4 ESS68127.1 - 0.00079 19.1 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2087) RNA_pol_Rpb4 PF03874.11 ESS68127.1 - 0.051 13.5 0.1 9.6 6.2 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb4 DUF3349 PF11829.3 ESS68127.1 - 0.063 13.7 0.4 0.37 11.2 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) MAP65_ASE1 PF03999.7 ESS68128.1 - 0.0097 14.5 0.2 0.0097 14.5 0.1 2.0 2 0 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) DASH_Dad1 PF08649.5 ESS68129.1 - 0.0049 16.5 0.2 0.083 12.5 0.0 2.5 2 0 0 2 2 2 1 DASH complex subunit Dad1 NIF PF03031.13 ESS68130.1 - 5.4e-32 110.6 0.3 1.1e-30 106.3 0.0 2.3 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESS68130.1 - 0.00095 19.4 1.3 0.062 13.5 0.1 3.1 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESS68130.1 - 0.014 15.8 0.0 0.1 13.0 0.0 1.9 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Evr1_Alr PF04777.8 ESS68131.1 - 1.2e-22 79.6 0.6 2.4e-22 78.6 0.4 1.5 1 0 0 1 1 1 1 Erv1 / Alr family DUF3827 PF12877.2 ESS68131.1 - 0.038 12.0 1.0 0.053 11.6 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) ThiF PF00899.16 ESS68132.1 - 1.1e-24 86.7 0.0 2.2e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 ESS68132.1 - 3.1e-08 33.1 0.4 2.2e-07 30.3 0.3 2.2 2 0 0 2 2 2 1 MoeZ/MoeB domain Erv26 PF04148.8 ESS68134.1 - 0.015 14.6 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 ELFV_dehydrog PF00208.16 ESS68135.1 - 2.5e-46 158.2 0.0 4.2e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 ESS68135.1 - 3.4e-15 54.6 0.1 6.7e-07 27.1 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 ESS68135.1 - 0.0074 15.8 0.0 0.03 13.9 0.0 2.0 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain polyprenyl_synt PF00348.12 ESS68136.1 - 2.8e-53 180.4 0.1 4.4e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.14 ESS68136.1 - 6.4e-05 22.3 1.4 0.0001 21.6 1.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase Exonuc_VII_L PF02601.10 ESS68137.1 - 3.2 6.8 8.5 4.2 6.4 5.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PLRV_ORF5 PF01690.12 ESS68137.1 - 4.6 6.2 6.9 5.2 6.1 4.8 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Peptidase_S46 PF10459.4 ESS68137.1 - 5.6 5.2 10.6 7.1 4.9 7.4 1.1 1 0 0 1 1 1 0 Peptidase S46 NAP PF00956.13 ESS68138.1 - 4.4e-76 255.2 6.8 4.4e-76 255.2 4.7 3.1 3 1 0 3 3 3 1 Nucleosome assembly protein (NAP) NOA36 PF06524.7 ESS68138.1 - 0.09 12.0 18.6 0.92 8.6 2.5 2.6 2 0 0 2 2 2 0 NOA36 protein TFIIB PF00382.14 ESS68139.1 - 0.0012 18.5 1.3 0.0021 17.8 0.1 2.0 2 0 0 2 2 2 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 ESS68139.1 - 0.0045 16.2 1.2 0.01 15.1 0.8 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 ESS68139.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Cyclin, N-terminal domain Hanta_nucleocap PF00846.13 ESS68139.1 - 0.056 12.1 0.0 0.091 11.4 0.0 1.2 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein Lar_restr_allev PF14354.1 ESS68139.1 - 0.067 13.5 0.4 0.17 12.2 0.3 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.1 ESS68139.1 - 0.16 11.2 0.9 0.53 9.5 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain DUF2387 PF09526.5 ESS68139.1 - 0.2 11.6 3.5 0.12 12.2 0.3 2.2 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Ribosomal_60s PF00428.14 ESS68139.1 - 5.5 7.4 8.7 0.13 12.7 1.3 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein KIAA1328 PF15369.1 ESS68143.1 - 0.093 12.5 0.8 0.19 11.5 0.5 1.5 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Pkinase PF00069.20 ESS68144.1 - 1.4e-56 191.5 0.0 2.3e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68144.1 - 1.2e-41 142.4 0.0 2e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.24 ESS68144.1 - 3.3e-23 81.2 0.2 1.4e-11 44.0 0.1 2.9 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Kinase-like PF14531.1 ESS68144.1 - 1.6e-07 30.6 0.0 5.6e-06 25.5 0.0 2.4 2 0 0 2 2 2 1 Kinase-like PAS_9 PF13426.1 ESS68144.1 - 3.2e-07 30.6 0.0 1.2e-06 28.7 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 ESS68144.1 - 4.3e-06 26.4 0.0 1.5e-05 24.7 0.0 2.0 1 0 0 1 1 1 1 PAS fold HATPase_c PF02518.21 ESS68144.1 - 0.0002 21.0 0.0 0.00049 19.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RIO1 PF01163.17 ESS68144.1 - 0.052 12.8 0.0 0.13 11.5 0.0 1.7 1 0 0 1 1 1 0 RIO1 family PAS_8 PF13188.1 ESS68144.1 - 0.081 12.8 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 PAS domain Kdo PF06293.9 ESS68144.1 - 0.097 11.7 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos PF03372.18 ESS68146.1 - 1.5e-17 64.3 0.0 3e-17 63.4 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.22 ESS68146.1 - 3.3e-12 46.2 0.0 6.7e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain Nucleoside_tran PF01733.13 ESS68147.1 - 1.1e-20 73.9 0.2 1.4e-20 73.6 0.2 1.0 1 0 0 1 1 1 1 Nucleoside transporter DUF3317 PF11779.3 ESS68147.1 - 8.9 5.8 7.6 1.2 8.6 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3317) UFC1 PF08694.6 ESS68148.1 - 1.2e-84 281.5 0.2 1.6e-84 281.2 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.21 ESS68148.1 - 0.0055 16.1 0.2 0.0087 15.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme CorA PF01544.13 ESS68149.1 - 1.4e-41 142.4 0.2 1.9e-41 142.0 0.2 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Dynamin_M PF01031.15 ESS68149.1 - 0.05 12.3 0.0 0.091 11.5 0.0 1.3 1 0 0 1 1 1 0 Dynamin central region IQ PF00612.22 ESS68151.1 - 0.00067 19.0 10.4 0.068 12.8 0.4 3.5 3 0 0 3 3 3 2 IQ calmodulin-binding motif IQ PF00612.22 ESS68152.1 - 3.4e-09 35.5 7.0 0.00015 21.0 0.8 3.2 2 0 0 2 2 2 2 IQ calmodulin-binding motif DNA_topoisoIV PF00521.15 ESS68153.1 - 1.3e-102 343.8 0.0 2.4e-102 342.9 0.0 1.5 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A Toprim PF01751.17 ESS68153.1 - 5.1e-12 45.6 0.0 2e-11 43.7 0.0 2.1 1 0 0 1 1 1 1 Toprim domain DNA_gyraseB PF00204.20 ESS68153.1 - 4.6e-09 35.7 0.0 1.1e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 ESS68153.1 - 2.9e-07 30.1 0.0 5.9e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UCH PF00443.24 ESS68154.1 - 5.1e-39 134.0 1.1 7.1e-39 133.5 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS68154.1 - 2.2e-24 86.3 0.1 3.4e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 ESS68154.1 - 2e-17 63.2 0.0 6.8e-13 48.4 0.0 3.3 3 0 0 3 3 3 2 ICP0-binding domain of Ubiquitin-specific protease 7 SHOCT PF09851.4 ESS68155.1 - 1.2e-06 27.7 0.0 2.1e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Short C-terminal domain DUF572 PF04502.8 ESS68155.1 - 0.14 11.3 3.1 0.19 10.9 2.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.4 ESS68155.1 - 1.1 7.4 6.6 1.4 7.0 4.6 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF2217 PF10265.4 ESS68155.1 - 2.5 6.7 7.6 3.8 6.1 5.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) MIF4G PF02854.14 ESS68156.1 - 6.5e-14 51.8 0.2 1.2e-12 47.6 0.0 2.8 3 0 0 3 3 3 1 MIF4G domain DUF2422 PF10337.4 ESS68156.1 - 0.016 14.0 8.4 0.53 9.0 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2422) Actin PF00022.14 ESS68157.1 - 3.7e-53 180.3 0.0 4.5e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Actin EF-hand_7 PF13499.1 ESS68158.1 - 1.4e-05 25.0 0.2 6e-05 23.0 0.0 2.1 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS68158.1 - 0.00048 19.7 0.1 0.019 14.7 0.1 3.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 ESS68158.1 - 0.0011 18.1 0.0 0.24 10.8 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.1 ESS68158.1 - 0.0088 15.6 4.7 0.035 13.7 0.1 3.2 4 0 0 4 4 4 1 EF-hand domain pair NIF PF03031.13 ESS68159.1 - 3e-05 23.7 0.0 5.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RabGAP-TBC PF00566.13 ESS68160.1 - 1.2e-07 31.3 0.0 2.7e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain 2OG-FeII_Oxy PF03171.15 ESS68161.1 - 4e-08 33.4 0.0 1e-07 32.1 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Actin PF00022.14 ESS68162.1 - 3.3e-91 305.6 0.0 5.3e-91 304.9 0.0 1.3 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESS68162.1 - 0.0032 16.1 0.0 0.74 8.3 0.0 2.3 2 1 0 2 2 2 2 MreB/Mbl protein DUF1796 PF08795.5 ESS68163.1 - 7e-51 172.1 0.0 1.2e-50 171.4 0.0 1.4 1 0 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) Nop PF01798.13 ESS68164.1 - 1.7e-53 179.9 3.1 4e-53 178.7 0.4 2.3 2 0 0 2 2 2 1 Putative snoRNA binding domain NOSIC PF08060.8 ESS68164.1 - 8.3e-27 92.7 0.1 1.7e-26 91.8 0.1 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 ESS68164.1 - 0.00019 21.5 0.6 0.87 9.7 0.0 2.7 1 1 1 2 2 2 2 NOP5NT (NUC127) domain PH_11 PF15413.1 ESS68165.1 - 0.0027 17.9 0.0 0.0075 16.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain TMEM164 PF14808.1 ESS68166.1 - 1.9e-11 43.6 7.9 2.5e-11 43.2 5.5 1.1 1 0 0 1 1 1 1 TMEM164 family zf-RING_2 PF13639.1 ESS68168.1 - 8e-12 44.7 17.3 1.9e-11 43.6 12.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESS68168.1 - 9.3e-08 32.0 9.9 1.9e-07 31.0 6.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESS68168.1 - 1.5e-06 28.1 13.3 2.7e-06 27.2 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESS68168.1 - 4.5e-05 23.0 14.0 7.9e-05 22.2 9.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS68168.1 - 0.00025 20.6 14.2 0.00045 19.8 9.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESS68168.1 - 0.00048 19.7 8.0 0.0011 18.6 5.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESS68168.1 - 0.013 15.1 16.6 0.03 14.0 11.5 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-Apc11 PF12861.2 ESS68168.1 - 0.11 12.4 10.7 0.3 10.9 7.4 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 ESS68168.1 - 0.17 11.8 13.7 2.1 8.3 9.5 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain MutS_V PF00488.16 ESS68169.1 - 2.5e-67 226.7 0.0 4.1e-67 226.0 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESS68169.1 - 4.3e-25 88.6 1.7 7.5e-25 87.9 1.2 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 ESS68169.1 - 9.5e-07 28.9 0.0 2.8e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 MutS family domain IV tRNA-synt_1c PF00749.16 ESS68170.1 - 1.6e-86 289.8 0.2 2e-86 289.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 ESS68170.1 - 8.6e-41 139.4 0.0 1.4e-40 138.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain PCNA_N PF00705.13 ESS68171.1 - 1.3e-41 141.0 0.7 6.2e-41 138.8 0.5 1.9 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 ESS68171.1 - 3.4e-36 123.9 0.1 4.2e-18 65.5 0.0 2.3 1 1 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 ESS68171.1 - 6.7e-08 31.9 0.0 1.3e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 Rad9 Rad1 PF02144.11 ESS68171.1 - 1.2e-05 24.2 0.2 0.00022 20.0 0.1 2.3 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.7 ESS68171.1 - 0.00081 18.4 0.2 0.019 13.9 0.1 2.4 3 0 0 3 3 3 1 Hus1-like protein GHMP_kinases_N PF00288.21 ESS68172.1 - 1e-07 31.9 0.3 6.3e-07 29.3 0.1 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain Luciferase_N PF05295.6 ESS68172.1 - 0.086 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain Hex_IIIa PF02455.11 ESS68173.1 - 0.27 9.8 10.0 0.28 9.8 6.9 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Pox_Ag35 PF03286.9 ESS68173.1 - 1.1 8.7 20.5 1.2 8.5 14.2 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein APC_CDC26 PF10471.4 ESS68173.1 - 3.3 8.5 14.6 4.6 8.0 10.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 Vfa1 PF08432.5 ESS68173.1 - 3.6 7.5 20.4 3.9 7.4 14.1 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDRGK PF09756.4 ESS68173.1 - 3.7 6.9 22.7 4.4 6.6 15.7 1.1 1 0 0 1 1 1 0 DDRGK domain MIP-T3 PF10243.4 ESS68173.1 - 3.9 5.8 29.5 4.1 5.7 20.4 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Rtf2 PF04641.7 ESS68173.1 - 4.3 6.4 20.1 4.9 6.2 13.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1168 PF06658.7 ESS68173.1 - 4.4 6.8 27.9 5.3 6.5 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DUF1387 PF07139.6 ESS68173.1 - 5.3 6.5 18.0 6.4 6.2 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FAM60A PF15396.1 ESS68173.1 - 6.3 6.4 14.9 6.5 6.4 10.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A U79_P34 PF03064.11 ESS68173.1 - 8.2 5.8 22.3 8.2 5.8 15.5 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 eIF3_subunit PF08597.5 ESS68173.1 - 8.4 5.8 21.7 10 5.5 15.1 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4407 PF14362.1 ESS68173.1 - 8.5 5.2 11.9 8.8 5.1 8.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1510 PF07423.6 ESS68173.1 - 9.7 5.4 20.0 10 5.3 13.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FAM176 PF14851.1 ESS68173.1 - 9.9 5.8 11.6 12 5.5 8.0 1.1 1 0 0 1 1 1 0 FAM176 family DGF-1_5 PF11038.3 ESS68191.1 - 2.2e-164 545.3 18.4 2.2e-164 545.3 12.8 1.5 2 0 0 2 2 2 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS68191.1 - 7.3e-49 163.5 1.6 1.4e-48 162.6 1.1 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Pkinase PF00069.20 ESS68192.1 - 2.4e-56 190.7 0.0 4.1e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68192.1 - 5.9e-38 130.4 0.0 1.6e-37 129.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68192.1 - 6.4e-06 25.3 0.0 1.1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESS68192.1 - 0.066 12.2 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HemY_N PF07219.8 ESS68192.1 - 0.13 11.8 0.2 5 6.7 0.2 2.4 2 0 0 2 2 2 0 HemY protein N-terminus zf-NF-X1 PF01422.12 ESS68193.1 - 3.5e-10 39.6 76.1 2.9e-05 23.9 8.5 14.2 16 1 1 17 17 17 7 NF-X1 type zinc finger ECH PF00378.15 ESS68194.1 - 1.7e-37 128.8 0.0 2.1e-37 128.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Mur_ligase PF01225.20 ESS68194.1 - 0.098 12.7 0.0 0.34 11.0 0.0 2.0 1 1 0 1 1 1 0 Mur ligase family, catalytic domain Rtt106 PF08512.7 ESS68195.1 - 4e-14 52.3 0.0 5.4e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Histone chaperone Rttp106-like YL1 PF05764.8 ESS68195.1 - 0.041 13.4 16.2 0.071 12.7 11.2 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.7 ESS68195.1 - 0.2 9.5 17.8 0.23 9.3 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-T PF15511.1 ESS68195.1 - 0.71 9.0 17.2 0.99 8.5 11.9 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TraH_2 PF06871.6 ESS68195.1 - 4.1 6.7 6.0 2.8 7.3 3.1 1.4 1 1 0 1 1 1 0 TraH_2 SDA1 PF05285.7 ESS68195.1 - 5.3 6.2 23.6 7.1 5.8 16.3 1.1 1 0 0 1 1 1 0 SDA1 SPT16 PF08644.6 ESS68196.1 - 5e-37 127.0 0.3 5e-37 127.0 0.2 1.8 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.19 ESS68196.1 - 1.3e-16 60.8 0.0 2.4e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribosomal_L3 PF00297.17 ESS68197.1 - 7.7e-13 48.4 0.1 1.3e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L3 2TM PF13239.1 ESS68197.1 - 3.8 7.6 9.2 11 6.2 6.4 1.7 1 0 0 1 1 1 0 2TM domain Rhabdo_glycop PF00974.13 ESS68197.1 - 6.9 4.7 6.3 10 4.1 4.4 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein tRNA-synt_1b PF00579.20 ESS68200.1 - 2.1e-18 66.5 0.0 1.1e-17 64.1 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) OATP PF03137.15 ESS68201.1 - 0.063 11.3 0.0 0.075 11.0 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RNase_H2-Ydr279 PF09468.5 ESS68201.1 - 0.067 12.3 7.2 0.072 12.2 5.0 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Zip PF02535.17 ESS68201.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter YqfQ PF14181.1 ESS68201.1 - 0.16 12.0 8.7 0.18 11.8 6.0 1.1 1 0 0 1 1 1 0 YqfQ-like protein Herpes_DNAp_acc PF04929.7 ESS68201.1 - 0.58 9.0 6.8 0.68 8.8 4.7 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor NARP1 PF12569.3 ESS68201.1 - 0.65 8.6 12.1 0.65 8.6 8.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF1168 PF06658.7 ESS68201.1 - 5.2 6.5 27.9 6.1 6.3 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Sec62 PF03839.11 ESS68201.1 - 5.3 6.3 11.1 6.9 6.0 7.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Med19 PF10278.4 ESS68201.1 - 9 5.9 18.9 12 5.5 13.1 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SNARE PF05739.14 ESS68202.1 - 5.6e-11 41.9 4.2 5.6e-11 41.9 2.9 2.5 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.1 ESS68202.1 - 3.3e-10 39.9 5.6 7.5e-10 38.7 0.5 2.3 2 1 0 2 2 2 1 Syntaxin-like protein MCPsignal PF00015.16 ESS68202.1 - 0.0006 19.4 1.5 0.0096 15.4 0.3 2.1 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Spc7 PF08317.6 ESS68202.1 - 0.002 16.8 0.1 0.002 16.8 0.1 2.0 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF1664 PF07889.7 ESS68202.1 - 0.14 11.9 1.7 0.97 9.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec20 PF03908.8 ESS68202.1 - 0.15 11.7 1.1 13 5.5 0.1 2.5 2 0 0 2 2 2 0 Sec20 Syntaxin PF00804.20 ESS68202.1 - 0.25 11.4 4.6 8.7 6.5 0.1 2.4 2 0 0 2 2 2 0 Syntaxin Synaptobrevin PF00957.16 ESS68202.1 - 0.65 9.6 4.3 0.24 11.0 0.1 2.5 3 1 0 4 4 4 0 Synaptobrevin WD40 PF00400.27 ESS68203.1 - 4.9e-15 54.7 7.9 0.0028 17.4 0.3 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat DUF4306 PF14154.1 ESS68203.1 - 0.051 13.5 0.1 6.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4306) 2TM PF13239.1 ESS68204.1 - 0.15 12.1 1.0 1.8 8.6 0.0 2.1 2 0 0 2 2 2 0 2TM domain DOCK-C2 PF14429.1 ESS68205.1 - 3.4e-29 101.8 0.0 1.3e-28 99.8 0.0 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins PC_rep PF01851.17 ESS68206.1 - 2.2e-27 93.6 15.8 8.6e-07 28.8 0.1 9.4 9 0 0 9 9 9 5 Proteasome/cyclosome repeat HEAT_EZ PF13513.1 ESS68206.1 - 0.00016 22.0 5.1 0.54 10.8 0.0 6.0 6 0 0 6 6 6 1 HEAT-like repeat IFRD PF05004.8 ESS68206.1 - 0.63 9.0 4.3 2.5 7.0 0.4 3.2 2 1 2 4 4 4 0 Interferon-related developmental regulator (IFRD) IQ PF00612.22 ESS68207.1 - 2.3 8.0 14.1 0.39 10.5 3.3 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif RNA_pol_A_bac PF01000.21 ESS68208.1 - 2.9e-22 78.9 0.0 5.3e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 ESS68208.1 - 7e-13 47.5 0.0 8.9e-13 47.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_7 PF12838.2 ESS68208.1 - 0.038 14.3 4.2 0.096 13.0 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain RcbX PF02341.10 ESS68208.1 - 0.053 13.6 0.1 0.38 10.8 0.0 2.4 1 1 0 1 1 1 0 RbcX protein Fer4_9 PF13187.1 ESS68208.1 - 0.066 13.4 0.3 0.066 13.4 0.2 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF2401 PF10287.4 ESS68208.1 - 0.12 11.8 0.5 0.19 11.2 0.4 1.3 1 0 0 1 1 1 0 Putative TOS1-like glycosyl hydrolase (DUF2401) Fer4 PF00037.22 ESS68208.1 - 4.1 7.1 9.0 0.35 10.5 0.3 2.8 3 0 0 3 3 3 0 4Fe-4S binding domain TPR_11 PF13414.1 ESS68209.1 - 4.9e-14 51.7 10.4 2.2e-06 27.2 0.1 5.4 3 1 2 5 5 5 4 TPR repeat TPR_19 PF14559.1 ESS68209.1 - 5.4e-11 42.6 7.8 0.026 14.8 0.1 5.4 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68209.1 - 4.1e-09 35.6 10.5 0.0024 17.6 0.0 7.4 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68209.1 - 2.6e-08 34.3 0.3 0.0015 19.1 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS68209.1 - 5.6e-08 32.6 5.8 0.001 18.9 0.1 6.0 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68209.1 - 6.4e-05 22.4 0.3 5.8 6.9 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS68209.1 - 0.00012 22.1 12.4 0.077 13.1 0.1 4.3 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESS68209.1 - 0.00027 20.4 12.5 0.38 10.4 0.1 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat MIT PF04212.13 ESS68209.1 - 0.047 13.5 5.2 5.2 7.0 0.0 3.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.1 ESS68209.1 - 0.053 13.3 4.3 14 5.7 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESS68209.1 - 0.056 13.6 1.9 14 6.1 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS68209.1 - 0.057 13.3 5.6 18 5.4 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68209.1 - 0.099 13.1 11.1 44 4.8 0.0 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS68209.1 - 0.23 11.3 11.8 0.57 10.0 0.0 3.7 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Foie-gras_1 PF11817.3 ESS68209.1 - 1.3 8.4 6.4 0.54 9.6 0.0 3.2 3 1 1 4 4 4 0 Foie gras liver health family 1 zf-RanBP PF00641.13 ESS68211.1 - 4.1e-05 22.5 2.2 7.5e-05 21.7 1.5 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RPA_interact_C PF14768.1 ESS68211.1 - 0.065 13.6 0.1 0.19 12.1 0.1 1.8 1 0 0 1 1 1 0 Replication protein A interacting C-terminal SR-25 PF10500.4 ESS68213.1 - 8.2 5.8 24.5 15 4.9 17.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SNF2_N PF00176.18 ESS68214.1 - 1.8e-30 105.8 0.0 2.5e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 ESS68214.1 - 4.3e-06 26.6 0.0 0.13 12.0 0.0 2.5 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESS68214.1 - 0.013 15.3 0.0 0.07 13.0 0.0 2.2 2 0 0 2 2 2 0 Helicase conserved C-terminal domain AAA_34 PF13872.1 ESS68214.1 - 0.02 13.6 0.0 0.037 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 AAA_22 PF13401.1 ESS68214.1 - 0.023 14.8 0.0 0.34 11.0 0.0 2.5 1 1 0 1 1 1 0 AAA domain Sec23_trunk PF04811.10 ESS68216.1 - 5e-40 137.3 0.0 7.2e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 ESS68216.1 - 6.8e-17 61.7 0.0 1.2e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 ESS68216.1 - 1.3e-16 59.8 6.6 2.6e-16 58.9 4.2 1.8 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.10 ESS68216.1 - 1.3e-13 50.2 0.0 3.7e-13 48.7 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 helical domain PAT1 PF09770.4 ESS68216.1 - 9.9 4.2 17.8 16 3.5 12.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GPI2 PF06432.6 ESS68217.1 - 0.003 16.9 0.6 0.003 16.9 0.4 1.8 2 0 0 2 2 2 1 Phosphatidylinositol N-acetylglucosaminyltransferase RIO1 PF01163.17 ESS68218.1 - 4.2e-65 218.6 0.9 4.9e-65 218.4 0.0 1.6 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESS68218.1 - 0.044 13.5 0.2 0.25 11.0 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DIOX_N PF14226.1 ESS68219.1 - 1.5e-34 119.0 0.0 2.2e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESS68219.1 - 7.6e-24 83.8 0.0 1.5e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TTL PF03133.10 ESS68220.1 - 8.3e-45 152.9 0.0 2.7e-20 72.5 0.0 3.1 2 1 0 2 2 2 2 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.9 ESS68220.1 - 0.15 11.9 0.0 9.6 6.0 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain ATPgrasp_YheCD PF14398.1 ESS68220.1 - 0.19 10.5 0.0 14 4.3 0.0 2.4 2 1 0 2 2 2 0 YheC/D like ATP-grasp Rho_N PF07498.7 ESS68221.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain FHA PF00498.21 ESS68222.1 - 1.5e-11 44.2 0.4 2.6e-10 40.2 0.1 2.5 2 1 0 2 2 2 1 FHA domain TPR_11 PF13414.1 ESS68223.1 - 2e-17 62.5 4.4 8.3e-10 38.1 0.6 2.7 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS68223.1 - 1.3e-08 34.0 12.3 0.016 15.0 0.0 4.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS68223.1 - 2.2e-08 33.3 0.6 0.04 13.5 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68223.1 - 6e-07 29.9 10.5 0.00032 21.2 1.6 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS68223.1 - 2.8e-06 27.0 0.3 2.8e-06 27.0 0.2 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS68223.1 - 2.7e-05 24.0 0.2 0.0021 18.1 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESS68223.1 - 0.00032 19.8 8.1 0.0058 15.7 0.0 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS68223.1 - 0.00073 19.1 0.1 0.8 9.6 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS68223.1 - 0.0056 16.7 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 ESS68223.1 - 0.016 15.1 9.0 0.97 9.4 0.0 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68223.1 - 0.02 15.2 4.7 0.034 14.4 0.4 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68223.1 - 0.037 13.8 4.9 0.58 10.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.3 ESS68223.1 - 0.043 12.5 10.4 0.33 9.6 0.0 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 BROMI PF14961.1 ESS68223.1 - 0.043 10.9 0.7 0.06 10.4 0.5 1.1 1 0 0 1 1 1 0 Broad-minded protein TPR_14 PF13428.1 ESS68223.1 - 0.075 13.7 15.6 0.54 11.0 0.4 4.6 2 1 3 5 5 4 0 Tetratricopeptide repeat DUF106 PF01956.11 ESS68223.1 - 0.19 11.2 0.7 0.28 10.6 0.5 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF106 ArfGap PF01412.13 ESS68224.1 - 1.3e-38 131.3 2.7 3.2e-38 130.0 0.1 2.3 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf ZZ PF00569.12 ESS68224.1 - 0.23 11.0 3.3 0.51 9.9 2.3 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type RRXRR PF14239.1 ESS68224.1 - 0.32 10.3 4.3 0.15 11.4 0.2 2.0 2 0 0 2 2 2 0 RRXRR protein BLVR PF06375.6 ESS68224.1 - 0.46 10.2 10.0 0.43 10.4 2.2 2.2 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) UBA_4 PF14555.1 ESS68225.1 - 5.7e-07 28.9 0.0 1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain SLT_2 PF13406.1 ESS68226.1 - 0.034 13.0 0.5 0.29 9.9 0.0 2.7 3 0 0 3 3 3 0 Transglycosylase SLT domain DUF3451 PF11933.3 ESS68227.1 - 0.00019 21.2 12.7 0.00019 21.2 8.8 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3451) DUF3250 PF11618.3 ESS68227.1 - 0.0041 17.2 0.0 0.05 13.7 0.0 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3250) Spc7 PF08317.6 ESS68227.1 - 0.36 9.4 51.4 0.16 10.5 10.9 5.7 3 1 2 5 5 5 0 Spc7 kinetochore protein NPV_P10 PF05531.7 ESS68227.1 - 3 8.1 10.7 2.7 8.3 0.1 4.6 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein RRM_1 PF00076.17 ESS68228.1 - 3.6e-18 64.9 0.1 2.5e-08 33.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68228.1 - 7.2e-09 35.4 0.1 0.0039 17.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS68228.1 - 1.2e-05 25.0 0.5 0.00022 21.0 0.0 2.7 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2524 PF10732.4 ESS68228.1 - 0.1 12.7 0.9 0.23 11.6 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) PPR_3 PF13812.1 ESS68231.1 - 3.2e-06 26.9 2.4 0.35 11.2 0.0 5.3 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR PF01535.15 ESS68231.1 - 0.00076 19.2 0.2 1.3 9.1 0.0 4.1 5 0 0 5 5 5 2 PPR repeat PPR_2 PF13041.1 ESS68231.1 - 0.015 15.2 0.1 3.5 7.6 0.0 4.0 2 1 1 4 4 4 0 PPR repeat family Metallophos PF00149.23 ESS68232.1 - 9e-07 28.4 0.1 1.6e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Rad51 PF08423.6 ESS68233.1 - 1.6e-07 30.5 1.7 0.0093 14.8 0.4 3.0 2 1 0 2 2 2 2 Rad51 AAA_25 PF13481.1 ESS68233.1 - 5.2e-06 25.9 2.4 4.9e-05 22.8 1.6 2.1 1 1 0 1 1 1 1 AAA domain KaiC PF06745.8 ESS68233.1 - 0.002 17.2 0.0 0.0038 16.3 0.0 1.5 1 0 0 1 1 1 1 KaiC RecA PF00154.16 ESS68233.1 - 0.0032 16.5 0.2 0.038 13.0 0.0 2.0 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ABC_tran PF00005.22 ESS68233.1 - 0.026 14.8 0.1 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.7 ESS68233.1 - 0.1 12.2 0.1 0.57 9.8 0.0 2.2 3 0 0 3 3 3 0 NACHT domain Involucrin_N PF10583.4 ESS68233.1 - 0.12 12.7 0.9 0.23 11.7 0.6 1.4 1 0 0 1 1 1 0 Involucrin of squamous epithelia N-terminus C_GCAxxG_C_C PF09719.5 ESS68234.1 - 0.034 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) UPF0444 PF15475.1 ESS68234.1 - 0.13 12.3 3.9 0.28 11.2 0.1 2.5 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Gly-zipper_YMGG PF13441.1 ESS68234.1 - 0.97 9.0 9.3 2.4 7.7 6.4 1.6 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.1 ESS68234.1 - 6.8 6.4 12.0 17 5.1 8.3 1.7 1 0 0 1 1 1 0 Glycine zipper Prolactin_RP PF15172.1 ESS68239.1 - 0.04 13.1 0.0 0.096 11.9 0.0 1.6 1 0 0 1 1 1 0 Prolactin-releasing peptide MerC PF03203.9 ESS68240.1 - 0.039 14.3 0.0 0.068 13.5 0.0 1.4 1 0 0 1 1 1 0 MerC mercury resistance protein ABA_WDS PF02496.11 ESS68240.1 - 0.069 13.3 0.1 0.25 11.5 0.2 1.7 2 0 0 2 2 2 0 ABA/WDS induced protein RNase_T PF00929.19 ESS68241.1 - 5.5e-24 85.2 0.0 1.3e-22 80.8 0.0 2.2 1 1 0 1 1 1 1 Exonuclease Peptidase_M19 PF01244.16 ESS68241.1 - 0.068 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) RNase_T PF00929.19 ESS68242.1 - 8.8e-21 74.8 0.0 1.4e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 Exonuclease RNase_T PF00929.19 ESS68243.1 - 2.5e-21 76.6 0.0 3.7e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Ank_2 PF12796.2 ESS68244.1 - 4.1e-11 43.0 0.1 1e-10 41.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESS68244.1 - 1.2e-07 31.2 3.2 0.044 13.6 0.1 4.5 4 1 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 ESS68244.1 - 1.8e-07 30.6 0.4 0.068 13.4 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 ESS68244.1 - 2.6e-06 27.7 0.3 0.0003 21.2 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESS68244.1 - 4.1e-06 26.8 2.7 0.001 19.2 0.3 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) ResIII PF04851.10 ESS68247.1 - 4e-15 56.1 0.0 6.6e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESS68247.1 - 2.8e-06 26.3 0.0 4.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 ESS68247.1 - 0.028 13.9 0.2 0.069 12.6 0.2 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase EF-hand_8 PF13833.1 ESS68248.1 - 0.01 15.4 1.9 1.3 8.6 0.0 2.8 2 1 1 3 3 3 0 EF-hand domain pair zf-CCHC_2 PF13696.1 ESS68249.1 - 1.8e-05 24.0 0.2 7.8e-05 22.0 0.2 2.1 1 0 0 1 1 1 1 Zinc knuckle zf-C2H2_jaz PF12171.3 ESS68249.1 - 0.0001 22.3 0.4 0.00023 21.2 0.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESS68249.1 - 0.023 14.8 0.1 0.054 13.7 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-CCHC_5 PF14787.1 ESS68249.1 - 0.17 11.3 6.8 0.042 13.3 1.7 2.3 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger ABC_tran PF00005.22 ESS68250.1 - 2.8e-25 89.1 0.0 4.5e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS68250.1 - 0.00021 21.3 0.2 0.056 13.3 0.0 2.1 1 1 0 2 2 2 2 AAA domain SRP54 PF00448.17 ESS68250.1 - 0.007 15.8 0.1 0.031 13.7 0.1 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain ABC2_membrane_3 PF12698.2 ESS68251.1 - 3.9e-48 164.2 50.9 1.7e-31 109.5 9.5 3.7 3 1 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.22 ESS68251.1 - 2.7e-28 98.9 0.0 4.4e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESS68251.1 - 2.8e-08 34.0 0.0 0.0048 16.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 ESS68251.1 - 0.0023 18.2 0.1 0.004 17.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ESS68251.1 - 0.0063 16.0 0.1 0.015 14.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC2_membrane PF01061.19 ESS68251.1 - 0.009 15.1 0.3 0.009 15.1 0.2 3.6 3 0 0 3 3 3 1 ABC-2 type transporter AAA_13 PF13166.1 ESS68251.1 - 0.011 14.2 0.0 0.015 13.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain YSIRK_signal PF04650.12 ESS68251.1 - 0.014 14.9 0.3 0.05 13.1 0.2 2.1 1 0 0 1 1 1 0 YSIRK type signal peptide SMC_N PF02463.14 ESS68251.1 - 0.044 13.0 0.1 0.39 9.8 0.1 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain SNARE PF05739.14 ESS68252.1 - 1.1e-06 28.1 0.2 1.7e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 SNARE domain VirB3 PF05101.8 ESS68252.1 - 1.3 9.0 6.9 6.6 6.7 0.1 2.3 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein DcpS_C PF11969.3 ESS68253.1 - 1.6e-24 86.3 0.2 2.9e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 ESS68253.1 - 5.9e-16 58.8 0.2 1.7e-15 57.3 0.0 1.8 2 0 0 2 2 2 1 HIT domain zf-C2H2_2 PF12756.2 ESS68253.1 - 0.065 13.3 0.2 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) PHO4 PF01384.15 ESS68254.1 - 1.5e-44 151.9 6.0 1.6e-44 151.9 4.2 1.1 1 0 0 1 1 1 1 Phosphate transporter family Radial_spoke PF04712.7 ESS68255.1 - 9.2e-135 450.1 1.5 1.4e-134 449.5 1.1 1.2 1 0 0 1 1 1 1 Radial spokehead-like protein RRM_1 PF00076.17 ESS68256.1 - 9e-24 82.9 0.0 1.9e-12 46.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68256.1 - 9.7e-20 70.3 0.0 2.3e-09 37.0 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS68256.1 - 6.3e-14 51.5 0.0 1.1e-05 25.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myc_N PF01056.13 ESS68256.1 - 0.23 10.5 3.1 0.59 9.2 1.8 1.9 2 0 0 2 2 2 0 Myc amino-terminal region PBP1_TM PF14812.1 ESS68256.1 - 9.8 6.5 10.3 3 8.1 4.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CLAMP PF14769.1 ESS68258.1 - 1.4e-05 25.1 0.2 0.00078 19.5 0.0 2.8 2 0 0 2 2 2 1 Flagellar C1a complex subunit C1a-32 BBS2_Mid PF14783.1 ESS68259.1 - 7.2e-06 25.7 0.0 0.0001 22.0 0.0 2.8 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region BBS2_C PF14782.1 ESS68259.1 - 0.00013 20.6 0.0 0.038 12.5 0.0 2.2 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, C-terminal EF_TS PF00889.14 ESS68260.1 - 1.6e-17 63.5 0.4 2.3e-17 63.0 0.2 1.2 1 0 0 1 1 1 1 Elongation factor TS UBA PF00627.26 ESS68260.1 - 0.028 14.2 0.1 0.081 12.8 0.0 1.9 2 0 0 2 2 2 0 UBA/TS-N domain Epimerase PF01370.16 ESS68261.1 - 1.6e-19 70.2 0.1 2.1e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESS68261.1 - 3.1e-09 36.1 0.0 4.3e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 ESS68261.1 - 8.4e-09 35.6 0.0 1.9e-08 34.5 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESS68261.1 - 2.1e-05 23.4 0.0 0.0002 20.1 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 ESS68261.1 - 2.5e-05 23.3 0.0 3.4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Saccharop_dh PF03435.13 ESS68261.1 - 0.0022 17.0 0.0 0.0032 16.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase KR PF08659.5 ESS68261.1 - 0.023 14.3 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.19 ESS68261.1 - 0.091 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.20 ESS68261.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase WD40 PF00400.27 ESS68262.1 - 2.2e-32 109.7 12.6 3.6e-08 32.9 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Mpp10 PF04006.7 ESS68263.1 - 1.2e-54 185.7 45.5 3.7e-53 180.8 31.5 2.9 1 1 0 1 1 1 1 Mpp10 protein HSP90 PF00183.13 ESS68264.1 - 3e-148 494.5 3.8 2.6e-145 484.8 1.0 2.3 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.1 ESS68264.1 - 6.4e-09 35.5 0.0 1.6e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESS68264.1 - 9.7e-06 25.2 0.0 2.1e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AbrB-like PF14250.1 ESS68264.1 - 0.037 13.9 0.1 3.5 7.5 0.0 2.9 3 0 0 3 3 3 0 AbrB-like transcriptional regulator Jiraiya PF15038.1 ESS68265.1 - 0.071 12.5 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Jiraiya U-box PF04564.10 ESS68266.1 - 7.9e-12 44.9 0.0 1.9e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 ESS68266.1 - 5.9e-06 25.7 0.0 1.6e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.1 ESS68266.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Ring finger domain GFO_IDH_MocA_C PF02894.12 ESS68266.1 - 0.17 11.7 0.0 0.44 10.3 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Band_7 PF01145.20 ESS68267.1 - 1.4e-22 80.4 0.1 2.1e-22 79.9 0.1 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF1423 PF07227.6 ESS68267.1 - 0.0074 14.9 0.7 0.0091 14.7 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1423) Band_7_1 PF13421.1 ESS68267.1 - 0.044 13.3 0.1 0.08 12.4 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family EGF_2 PF07974.8 ESS68272.1 - 0.0045 17.1 11.9 0.0045 17.1 8.3 5.6 5 0 0 5 5 5 3 EGF-like domain Laminin_EGF PF00053.19 ESS68272.1 - 0.005 16.7 18.7 0.005 16.7 13.0 4.5 2 1 2 4 4 4 1 Laminin EGF-like (Domains III and V) BNR_3 PF13859.1 ESS68283.1 - 4.2e-61 206.7 0.1 9.2e-61 205.5 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS68283.1 - 3.6e-09 37.0 2.6 9.2e-09 35.7 0.0 2.6 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily BNR_2 PF13088.1 ESS68283.1 - 3.9e-05 23.0 0.2 0.00015 21.1 0.1 1.9 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS68283.1 - 0.0053 16.3 2.2 0.11 12.4 0.3 3.2 2 0 0 2 2 2 1 BNR/Asp-box repeat DUF3966 PF13110.1 ESS68285.1 - 0.23 11.2 0.3 0.48 10.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3966) 2_5_RNA_ligase2 PF13563.1 ESS68287.1 - 0.0048 16.6 0.0 2.8 7.6 0.0 2.2 2 0 0 2 2 2 2 2'-5' RNA ligase superfamily LRR_4 PF12799.2 ESS68289.1 - 1.3e-41 139.5 45.4 1.1e-05 24.9 0.5 15.0 7 4 11 18 18 18 16 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS68289.1 - 2.9e-29 100.5 57.5 6.8e-06 25.7 0.1 11.2 8 3 4 12 12 12 8 Leucine rich repeat LRR_6 PF13516.1 ESS68289.1 - 1.6e-19 67.7 58.7 0.036 14.1 0.0 19.7 18 2 1 19 19 19 7 Leucine Rich repeat LRR_1 PF00560.28 ESS68289.1 - 1.2e-07 30.7 58.1 0.94 9.7 0.2 17.0 14 6 2 16 16 16 4 Leucine Rich Repeat LRR_5 PF13306.1 ESS68289.1 - 7e-05 22.5 6.2 3.4 7.3 0.0 5.6 3 2 2 6 6 6 3 Leucine rich repeats (6 copies) LRR_9 PF14580.1 ESS68289.1 - 0.017 14.6 14.9 0.74 9.3 0.5 5.7 3 1 1 6 6 6 0 Leucine-rich repeat LRR_7 PF13504.1 ESS68289.1 - 0.44 10.9 71.3 0.45 10.9 0.4 17.9 19 4 1 20 20 20 0 Leucine rich repeat WD40 PF00400.27 ESS68290.1 - 4.8e-49 162.5 22.5 3.6e-09 36.1 2.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESS68290.1 - 0.00099 17.3 2.6 0.06 11.4 0.1 3.0 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESS68290.1 - 0.06 12.0 0.0 5.5 5.6 0.0 3.1 2 1 1 3 3 3 0 Nup133 N terminal like PPR_2 PF13041.1 ESS68291.1 - 9.3e-46 153.5 5.8 2e-15 56.4 0.1 6.1 1 1 5 6 6 6 6 PPR repeat family PPR_3 PF13812.1 ESS68291.1 - 2e-39 130.5 6.3 1.1e-08 34.6 0.0 6.4 6 0 0 6 6 6 6 Pentatricopeptide repeat domain PPR PF01535.15 ESS68291.1 - 7.3e-34 113.3 0.0 7.5e-07 28.7 0.0 6.5 6 0 0 6 6 6 5 PPR repeat PPR_1 PF12854.2 ESS68291.1 - 4.2e-26 90.1 0.0 6e-05 22.4 0.0 5.6 6 0 0 6 6 6 5 PPR repeat TPR_7 PF13176.1 ESS68291.1 - 7.7e-08 31.5 0.0 0.0025 17.4 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68291.1 - 2.2e-07 30.9 3.4 0.019 15.5 0.0 5.7 5 1 2 7 7 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68291.1 - 0.00034 20.9 0.6 0.19 12.0 0.0 3.3 2 1 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS68291.1 - 0.0004 20.4 0.0 0.28 11.3 0.0 3.3 1 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ESS68291.1 - 0.00046 20.7 0.3 0.18 12.5 0.1 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESS68291.1 - 0.00051 19.1 1.2 0.37 9.8 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS68291.1 - 0.00073 19.4 2.0 0.047 13.6 0.0 3.8 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68291.1 - 0.0044 16.8 0.0 0.2 11.6 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS68291.1 - 0.0048 16.7 0.4 0.039 13.8 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS68291.1 - 0.0076 15.8 1.6 0.24 11.0 0.0 3.1 4 0 0 4 4 4 1 TPR repeat TPR_6 PF13174.1 ESS68291.1 - 0.011 16.1 0.1 9.9 6.8 0.0 3.8 4 1 0 4 4 3 0 Tetratricopeptide repeat Clathrin PF00637.15 ESS68291.1 - 0.011 15.2 0.0 0.92 9.0 0.0 3.3 1 1 1 2 2 2 0 Region in Clathrin and VPS DUF1249 PF06853.7 ESS68291.1 - 0.15 11.6 0.4 0.96 9.0 0.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1249) DUF1749 PF08538.5 ESS68293.1 - 2e-16 59.7 0.0 3.2e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) FAST_1 PF06743.10 ESS68294.1 - 1.4e-07 31.0 0.1 0.011 15.4 0.0 4.5 4 1 0 4 4 4 3 FAST kinase-like protein, subdomain 1 RE_SacI PF09566.5 ESS68295.1 - 0.0012 17.8 0.2 0.002 17.1 0.1 1.3 1 0 0 1 1 1 1 SacI restriction endonuclease FAST_1 PF06743.10 ESS68295.1 - 0.0082 15.8 1.9 10 5.8 0.1 3.4 3 0 0 3 3 3 2 FAST kinase-like protein, subdomain 1 GidB PF02527.10 ESS68295.1 - 0.089 11.9 2.2 1.4 7.9 0.1 3.1 2 1 2 4 4 4 0 rRNA small subunit methyltransferase G RabGAP-TBC PF00566.13 ESS68297.1 - 5.6e-06 25.9 4.6 1.1e-05 25.0 3.2 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain WD40 PF00400.27 ESS68298.1 - 1.4e-15 56.4 1.4 0.0015 18.3 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat Nop14 PF04147.7 ESS68298.1 - 0.13 10.1 14.2 0.21 9.4 9.8 1.2 1 0 0 1 1 1 0 Nop14-like family Abhydrolase_6 PF12697.2 ESS68299.1 - 1.6e-19 70.6 0.0 5.1e-19 69.0 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS68299.1 - 0.0013 18.3 0.0 0.032 13.7 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold VPS9 PF02204.13 ESS68302.1 - 2.4e-34 117.4 0.0 4.8e-34 116.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Abhydrolase_2 PF02230.11 ESS68303.1 - 7.7e-06 25.4 0.0 7.3e-05 22.3 0.0 2.1 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 ESS68303.1 - 0.00031 20.5 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS68303.1 - 0.00044 20.1 0.0 0.0018 18.1 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESS68303.1 - 0.00052 19.2 1.3 0.74 8.9 0.2 3.2 2 1 1 3 3 3 2 Prolyl oligopeptidase family Esterase_phd PF10503.4 ESS68303.1 - 0.00069 18.9 0.1 0.0015 17.8 0.0 1.5 1 1 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_1 PF00561.15 ESS68303.1 - 0.0082 15.7 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.8 ESS68303.1 - 0.011 15.1 0.0 0.027 13.9 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Peptidase_M56 PF05569.6 ESS68303.1 - 0.18 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 Myosin_head PF00063.16 ESS68306.1 - 2.2e-180 601.1 0.0 1.9e-179 598.0 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 ESS68306.1 - 0.016 15.3 0.6 0.13 12.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESS68306.1 - 0.22 11.4 0.0 0.22 11.4 0.0 3.0 2 1 0 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 ESS68306.1 - 0.28 12.0 0.0 0.28 12.0 0.0 3.5 3 1 0 3 3 3 0 AAA domain Snurportin1 PF11538.3 ESS68306.1 - 0.88 9.3 7.2 1.9 8.3 0.5 3.8 3 0 0 3 3 3 0 Snurportin1 DUF4207 PF13904.1 ESS68306.1 - 4.4 6.6 14.5 9.4 5.5 10.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) P16-Arc PF04699.9 ESS68307.1 - 0.037 14.0 1.2 0.69 9.9 0.5 2.4 2 0 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) SNARE PF05739.14 ESS68308.1 - 0.00019 21.0 5.0 0.00044 19.8 2.2 2.2 2 0 0 2 2 2 1 SNARE domain DUF3361 PF11841.3 ESS68308.1 - 0.031 14.0 1.7 0.037 13.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) TMF_DNA_bd PF12329.3 ESS68308.1 - 0.038 13.8 0.7 0.038 13.8 0.5 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FliJ PF02050.11 ESS68308.1 - 1.1 9.3 12.7 1.8 8.6 0.1 3.2 2 1 1 3 3 3 0 Flagellar FliJ protein Hypoth_Ymh PF09509.5 ESS68308.1 - 1.6 8.3 5.8 0.67 9.5 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) zf-HC5HC2H_2 PF13832.1 ESS68309.1 - 8.7e-09 35.3 12.4 8.7e-09 35.3 8.6 3.0 2 1 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 ESS68309.1 - 1.3e-08 34.8 10.3 1.3e-08 34.8 7.1 3.2 2 1 0 3 3 3 1 PHD-like zinc-binding domain BBS2_N PF14781.1 ESS68310.1 - 0.0095 15.5 0.1 4.6 6.8 0.0 2.9 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, N-terminal PSP1 PF04468.7 ESS68311.1 - 5e-31 106.5 0.5 9.2e-31 105.6 0.4 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region ABC1 PF03109.11 ESS68312.1 - 1.3e-23 83.2 0.0 2.5e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.20 ESS68312.1 - 0.023 13.8 0.0 0.065 12.3 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain APH PF01636.18 ESS68312.1 - 0.053 13.2 0.0 0.19 11.4 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family PPR_3 PF13812.1 ESS68312.1 - 0.073 13.3 0.0 0.31 11.4 0.0 2.1 1 0 0 1 1 1 0 Pentatricopeptide repeat domain PPR PF01535.15 ESS68312.1 - 0.093 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 PPR repeat Ribosomal_L18e PF00828.14 ESS68314.1 - 2.8e-20 72.9 0.1 5e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 DUF2870 PF11069.3 ESS68315.1 - 4.3e-39 132.5 1.2 6.1e-39 132.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) Caps_synth_GfcC PF06251.6 ESS68315.1 - 0.1 11.7 0.8 0.89 8.6 0.0 2.3 2 1 0 2 2 2 0 Capsule biosynthesis GfcC MTS PF05175.9 ESS68316.1 - 1.7e-14 53.5 0.2 2.1e-11 43.5 0.0 2.8 2 1 1 3 3 3 2 Methyltransferase small domain Methyltransf_26 PF13659.1 ESS68316.1 - 1e-12 48.1 0.0 2.9e-12 46.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS68316.1 - 1.7e-11 43.9 0.0 2.5e-10 40.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESS68316.1 - 1.1e-08 34.5 1.5 2.5e-08 33.4 0.0 2.1 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 ESS68316.1 - 1.4e-08 35.3 0.0 4.6e-08 33.6 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 ESS68316.1 - 3e-07 30.0 0.0 8.5e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 ESS68316.1 - 1.9e-06 28.1 0.0 4.4e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 ESS68316.1 - 1.1e-05 25.1 0.1 0.00017 21.2 0.1 2.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.11 ESS68316.1 - 1.7e-05 24.4 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Ubie_methyltran PF01209.13 ESS68316.1 - 3.5e-05 23.0 0.2 7.4e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 ESS68316.1 - 8.4e-05 22.2 0.0 0.00019 21.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 ESS68316.1 - 0.00014 21.3 0.2 0.012 14.9 0.0 2.5 1 1 1 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.5 ESS68316.1 - 0.00014 21.4 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.7 ESS68316.1 - 0.00039 20.8 0.4 0.003 17.9 0.1 2.5 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS68316.1 - 0.00054 20.3 0.0 0.002 18.5 0.0 2.0 2 1 0 2 2 1 1 Methyltransferase domain TRM PF02005.11 ESS68316.1 - 0.0017 17.3 0.0 0.003 16.5 0.0 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_4 PF02390.12 ESS68316.1 - 0.0026 16.8 0.0 0.0088 15.1 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_23 PF13489.1 ESS68316.1 - 0.0039 16.9 0.0 0.008 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 ESS68316.1 - 0.064 12.3 0.0 0.13 11.2 0.0 1.5 1 1 0 1 1 1 0 N-6 DNA Methylase PCMT PF01135.14 ESS68316.1 - 0.064 12.7 0.1 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Eco57I PF07669.6 ESS68316.1 - 0.095 13.0 0.3 0.3 11.4 0.0 2.0 2 0 0 2 2 1 0 Eco57I restriction-modification methylase Aa_trans PF01490.13 ESS68317.1 - 1.1e-43 149.2 15.7 5e-43 147.1 10.9 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DnaJ PF00226.26 ESS68318.1 - 6.3e-23 80.2 0.2 6.3e-23 80.2 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain NB-ARC PF00931.17 ESS68318.1 - 0.014 14.2 0.4 0.023 13.5 0.2 1.3 1 0 0 1 1 1 0 NB-ARC domain E2F_TDP PF02319.15 ESS68318.1 - 0.046 13.2 0.0 0.19 11.3 0.0 2.1 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain Peptidase_M3 PF01432.15 ESS68320.1 - 6.5e-76 256.2 0.0 4e-75 253.6 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M3 TPR_17 PF13431.1 ESS68321.1 - 6.7e-10 38.3 2.5 0.00013 21.8 0.4 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68321.1 - 8.1e-08 32.4 0.3 5.4e-05 23.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS68321.1 - 3.1e-07 29.9 1.3 9.9e-06 25.1 0.3 3.2 4 0 0 4 4 4 1 TPR repeat TPR_14 PF13428.1 ESS68321.1 - 2.1e-06 27.8 0.2 0.067 13.8 0.3 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68321.1 - 1.7e-05 24.3 2.8 0.00089 18.9 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68321.1 - 3.3e-05 24.4 0.5 0.00065 20.3 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS68321.1 - 0.00055 20.0 0.4 0.023 14.8 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESS68321.1 - 0.00061 19.2 1.1 0.28 10.8 0.6 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68321.1 - 0.001 18.7 0.3 0.6 10.0 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68321.1 - 0.0033 17.7 0.7 0.08 13.4 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS68321.1 - 0.0079 16.1 0.3 0.025 14.4 0.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESS68321.1 - 0.011 15.8 0.1 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat BTAD PF03704.12 ESS68321.1 - 0.034 14.4 0.1 0.07 13.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial transcriptional activator domain RPN7 PF10602.4 ESS68321.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 NOB1_Zn_bind PF08772.6 ESS68322.1 - 0.007 16.1 1.1 0.016 15.0 0.1 2.2 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like DUF3800 PF12686.2 ESS68322.1 - 0.028 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) zf-B_box PF00643.19 ESS68322.1 - 0.044 13.6 0.4 0.044 13.6 0.3 2.5 2 1 0 2 2 2 0 B-box zinc finger Asparaginase PF00710.15 ESS68323.1 - 3.3e-67 226.5 0.0 3.8e-67 226.3 0.0 1.0 1 0 0 1 1 1 1 Asparaginase DEAD PF00270.24 ESS68325.1 - 7.5e-34 116.6 0.0 6.5e-33 113.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS68325.1 - 6.9e-26 89.9 0.1 1.9e-25 88.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESS68325.1 - 0.0042 17.2 0.7 9.1 6.4 0.0 4.0 3 0 0 3 3 3 1 AAA domain Helicase_C_2 PF13307.1 ESS68325.1 - 0.042 13.8 0.0 0.13 12.1 0.0 1.9 1 0 0 1 1 1 0 Helicase C-terminal domain DUF1253 PF06862.7 ESS68325.1 - 0.059 11.7 0.4 0.17 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) DivIC PF04977.10 ESS68325.1 - 1.5 8.3 7.4 0.23 10.9 0.5 2.7 1 1 1 2 2 2 0 Septum formation initiator ResIII PF04851.10 ESS68325.1 - 2 8.1 5.7 2.5 7.8 0.3 3.5 4 1 0 4 4 4 0 Type III restriction enzyme, res subunit Spc97_Spc98 PF04130.8 ESS68326.1 - 9.8e-87 291.4 0.0 1.3e-86 291.1 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family AOX PF01786.12 ESS68327.1 - 6.2e-78 260.9 0.5 9.2e-78 260.3 0.3 1.2 1 0 0 1 1 1 1 Alternative oxidase HECT PF00632.20 ESS68328.1 - 4.7e-71 239.5 0.0 9.7e-70 235.2 0.0 2.7 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) AAA PF00004.24 ESS68329.1 - 1.9e-43 147.8 0.2 5.4e-43 146.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESS68329.1 - 5.3e-07 29.4 0.0 2.5e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS68329.1 - 1e-06 28.8 1.0 5.9e-06 26.4 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 ESS68329.1 - 2e-06 27.8 0.0 5.2e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESS68329.1 - 1.4e-05 25.2 0.2 0.00054 20.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESS68329.1 - 3.4e-05 22.9 0.0 9e-05 21.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESS68329.1 - 4.1e-05 23.2 0.1 0.00016 21.3 0.1 2.0 2 0 0 2 2 1 1 Part of AAA domain AAA_17 PF13207.1 ESS68329.1 - 7.1e-05 23.6 0.2 0.00022 21.9 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.1 ESS68329.1 - 0.00026 20.8 0.4 0.0047 16.8 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_14 PF13173.1 ESS68329.1 - 0.00028 20.7 0.0 0.0049 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESS68329.1 - 0.00034 20.0 0.0 0.00086 18.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 ESS68329.1 - 0.0014 18.0 0.5 0.088 12.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain KaiC PF06745.8 ESS68329.1 - 0.0016 17.5 0.3 0.068 12.2 0.0 2.6 3 0 0 3 3 3 1 KaiC TIP49 PF06068.8 ESS68329.1 - 0.0026 16.5 0.3 0.0081 14.9 0.0 2.0 3 0 0 3 3 3 1 TIP49 C-terminus Zeta_toxin PF06414.7 ESS68329.1 - 0.0031 16.6 0.1 0.0099 14.9 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin Sigma54_activ_2 PF14532.1 ESS68329.1 - 0.0032 17.5 0.5 0.15 12.1 0.0 3.3 3 1 1 4 4 4 1 Sigma-54 interaction domain APG6 PF04111.7 ESS68329.1 - 0.0033 16.5 0.6 0.0061 15.6 0.4 1.4 1 0 0 1 1 1 1 Autophagy protein Apg6 AAA_28 PF13521.1 ESS68329.1 - 0.0033 17.4 0.0 0.0076 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 ESS68329.1 - 0.0041 16.7 0.0 0.014 14.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 ESS68329.1 - 0.0049 16.0 0.0 0.014 14.6 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 ESS68329.1 - 0.0068 15.6 0.1 0.069 12.3 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_18 PF13238.1 ESS68329.1 - 0.0089 16.3 0.0 0.026 14.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 ESS68329.1 - 0.011 15.1 0.1 0.059 12.8 0.0 2.3 2 1 0 2 2 1 0 Sigma-54 interaction domain RNA_helicase PF00910.17 ESS68329.1 - 0.012 15.7 0.0 0.029 14.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 ESS68329.1 - 0.013 15.1 0.0 0.041 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATP-synt_F6 PF05511.6 ESS68329.1 - 0.022 14.6 0.1 0.052 13.4 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 DUF815 PF05673.8 ESS68329.1 - 0.028 13.3 0.5 0.086 11.7 0.0 2.0 3 0 0 3 3 2 0 Protein of unknown function (DUF815) AAA_11 PF13086.1 ESS68329.1 - 0.029 13.9 0.9 0.31 10.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 ESS68329.1 - 0.034 13.0 0.3 0.069 12.0 0.0 1.5 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 DASH_Dad2 PF08654.5 ESS68329.1 - 0.049 13.6 1.3 0.12 12.3 0.9 1.7 1 0 0 1 1 1 0 DASH complex subunit Dad2 Tropomyosin_1 PF12718.2 ESS68329.1 - 0.05 13.4 2.7 0.071 12.9 1.0 1.9 2 0 0 2 2 1 0 Tropomyosin like NACHT PF05729.7 ESS68329.1 - 0.069 12.8 0.2 0.59 9.7 0.0 2.5 3 0 0 3 3 3 0 NACHT domain AAA_23 PF13476.1 ESS68329.1 - 0.25 11.6 3.0 21 5.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain Nucleoplasmin PF03066.10 ESS68332.1 - 0.017 14.6 6.1 0.037 13.5 4.3 1.5 1 0 0 1 1 1 0 Nucleoplasmin Myc_N PF01056.13 ESS68332.1 - 0.018 14.2 2.2 0.029 13.5 1.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Pro_3_hydrox_C PF05373.6 ESS68332.1 - 0.053 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal XAP5 PF04921.9 ESS68332.1 - 0.067 12.7 4.2 0.12 11.9 2.9 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator BSP_II PF05432.6 ESS68332.1 - 0.65 9.2 11.5 0.97 8.6 7.9 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CENP-B_dimeris PF09026.5 ESS68332.1 - 8.9 6.6 10.8 21 5.4 7.5 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.9 ESS68332.1 - 9.7 4.0 7.3 14 3.5 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein C2 PF00168.25 ESS68333.1 - 4.7e-19 68.0 2.2 9.6e-09 34.9 0.0 3.4 3 0 0 3 3 3 3 C2 domain CEP76-C2 PF15627.1 ESS68333.1 - 0.0011 18.4 0.1 0.16 11.4 0.0 3.1 3 0 0 3 3 3 1 CEP76 C2 domain DOCK-C2 PF14429.1 ESS68333.1 - 0.0015 18.1 0.0 0.083 12.5 0.0 2.4 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins C2 PF00168.25 ESS68335.1 - 5.3e-35 119.1 0.6 2.2e-09 37.0 0.0 7.2 7 0 0 7 7 7 6 C2 domain CEP76-C2 PF15627.1 ESS68335.1 - 0.0038 16.7 0.6 1.3 8.5 0.0 4.1 5 0 0 5 5 5 1 CEP76 C2 domain CC2D2AN-C2 PF15625.1 ESS68335.1 - 0.16 11.4 2.0 4.5 6.7 0.1 3.4 4 0 0 4 4 4 0 CC2D2A N-terminal C2 domain SET PF00856.23 ESS68336.1 - 2.9e-13 50.4 0.0 4.7e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 SET domain CHAP PF05257.11 ESS68337.1 - 7.7e-14 51.4 0.0 1.3e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 CHAP domain Arf PF00025.16 ESS68338.1 - 9.3e-16 57.5 0.0 2e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESS68338.1 - 1.3e-05 24.5 0.0 2.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 ESS68338.1 - 0.00018 21.9 0.1 0.00084 19.8 0.0 2.1 3 0 0 3 3 3 1 Miro-like protein MMR_HSR1 PF01926.18 ESS68338.1 - 0.00087 19.2 0.0 0.0022 17.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase PBP PF01161.15 ESS68338.1 - 0.0038 17.0 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein LAGLIDADG_WhiA PF14527.1 ESS68338.1 - 0.13 12.1 0.0 21 5.0 0.0 3.7 3 1 1 4 4 4 0 WhiA LAGLIDADG-like domain PH PF00169.24 ESS68339.1 - 0.013 15.7 0.2 0.053 13.7 0.1 2.0 2 1 0 2 2 2 0 PH domain F-box-like_2 PF13013.1 ESS68339.1 - 0.057 13.1 0.5 3.1 7.5 0.0 2.5 1 1 1 2 2 2 0 F-box-like domain TPR_14 PF13428.1 ESS68340.1 - 9.8e-12 44.4 28.6 0.0084 16.6 0.0 10.7 9 2 4 13 13 11 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68340.1 - 1.6e-06 27.5 5.1 5.3 7.1 0.2 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68340.1 - 4e-06 27.0 1.0 0.062 13.6 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68340.1 - 0.00026 21.5 32.1 2.6 8.8 0.0 8.9 8 2 1 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESS68340.1 - 0.00033 20.4 6.9 0.041 13.7 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68340.1 - 0.0019 17.8 2.3 4.9 7.1 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68340.1 - 0.0027 18.0 6.0 16 6.2 0.0 6.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS68340.1 - 0.0048 16.8 12.8 0.35 10.8 0.1 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat NRDE-2 PF08424.5 ESS68340.1 - 0.018 13.9 7.3 0.5 9.1 0.2 3.7 4 1 0 4 4 4 0 NRDE-2, necessary for RNA interference HAT PF02184.11 ESS68340.1 - 0.019 14.7 23.2 1.9 8.3 0.2 7.7 9 0 0 9 9 9 0 HAT (Half-A-TPR) repeat Suf PF05843.9 ESS68340.1 - 0.022 14.5 7.3 7 6.2 0.0 4.6 5 1 0 5 5 5 0 Suppressor of forked protein (Suf) DUF2063 PF09836.4 ESS68340.1 - 0.03 14.3 0.1 0.18 11.8 0.0 2.4 2 0 0 2 2 1 0 Uncharacterized protein conserved in bacteria (DUF2063) PPR PF01535.15 ESS68340.1 - 0.33 11.0 2.2 28 4.9 0.0 4.5 4 0 0 4 4 4 0 PPR repeat Apc3 PF12895.2 ESS68340.1 - 0.41 10.8 5.1 0.5 10.5 0.0 3.4 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 LURAP PF14854.1 ESS68342.1 - 0.1 12.3 3.0 0.069 12.8 0.4 1.9 2 0 0 2 2 2 0 Leucine rich adaptor protein Pkinase PF00069.20 ESS68343.1 - 6.2e-49 166.4 0.0 8.3e-49 166.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68343.1 - 9.1e-21 74.0 0.0 1.5e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS68343.1 - 6.1e-05 22.8 0.2 0.0044 16.7 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS68343.1 - 0.022 13.8 0.0 0.04 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAT1 PF09770.4 ESS68343.1 - 8.7 4.4 14.3 12 4.0 9.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WD40 PF00400.27 ESS68344.1 - 1.1e-15 56.7 6.2 8.5e-05 22.2 0.0 6.4 8 0 0 8 8 8 4 WD domain, G-beta repeat DUF2730 PF10805.3 ESS68345.1 - 0.054 13.2 17.4 0.047 13.4 0.8 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2730) Tfb4 PF03850.9 ESS68345.1 - 0.16 11.2 2.3 0.15 11.2 0.2 2.0 2 0 0 2 2 2 0 Transcription factor Tfb4 LMBR1 PF04791.11 ESS68345.1 - 0.39 9.2 5.1 0.79 8.2 3.5 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Tweety PF04906.8 ESS68345.1 - 0.93 7.8 4.9 0.64 8.3 0.4 2.6 1 1 0 1 1 1 0 Tweety LRR_6 PF13516.1 ESS68346.1 - 1.5e-43 141.8 58.8 0.00099 18.9 0.3 20.6 21 1 1 22 22 22 14 Leucine Rich repeat LRR_4 PF12799.2 ESS68346.1 - 3.9e-19 67.8 47.2 0.00016 21.2 1.0 13.1 11 3 2 13 13 13 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS68346.1 - 3.1e-14 50.8 34.3 0.25 11.5 0.1 16.3 17 1 0 17 17 17 5 Leucine Rich Repeat LRR_8 PF13855.1 ESS68346.1 - 1.6e-10 40.5 39.4 0.0068 16.1 0.5 11.5 11 2 1 12 12 12 6 Leucine rich repeat LRR_7 PF13504.1 ESS68346.1 - 0.00037 20.2 26.9 8.2 7.1 0.0 12.1 15 0 0 15 15 15 2 Leucine rich repeat XPC-binding PF09280.6 ESS68346.1 - 0.032 13.6 3.7 3.7 7.0 0.3 2.9 2 0 0 2 2 2 0 XPC-binding domain zf-CCHC_3 PF13917.1 ESS68348.1 - 8 6.2 10.3 0.28 10.9 2.1 2.3 3 0 0 3 3 3 0 Zinc knuckle MAD PF05557.8 ESS68349.1 - 0.012 13.6 2.6 0.015 13.3 1.8 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein IFT57 PF10498.4 ESS68349.1 - 0.022 13.5 1.6 0.028 13.1 1.1 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESS68349.1 - 0.034 13.1 1.2 0.043 12.7 0.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ATP-synt_D PF01813.12 ESS68349.1 - 0.064 12.7 0.3 0.09 12.3 0.2 1.2 1 0 0 1 1 1 0 ATP synthase subunit D Y_phosphatase PF00102.22 ESS68350.1 - 4.8e-66 222.4 0.2 8.2e-66 221.7 0.0 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ESS68350.1 - 0.00062 20.0 0.1 0.0033 17.6 0.0 2.2 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 ESS68350.1 - 0.0082 15.7 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESS68350.1 - 0.011 15.8 0.1 0.12 12.3 0.0 2.5 2 0 0 2 2 2 0 Inositol hexakisphosphate Pyr_redox_2 PF07992.9 ESS68351.1 - 6e-28 98.0 0.0 1.4e-27 96.9 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS68351.1 - 2e-09 37.6 1.3 6.3e-08 32.9 0.9 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESS68351.1 - 7.7e-06 25.0 2.6 0.00096 18.1 0.1 3.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESS68351.1 - 6e-05 23.1 2.5 0.00057 20.0 0.2 3.0 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS68351.1 - 0.003 17.5 0.1 0.28 11.2 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 ESS68351.1 - 0.019 13.8 0.6 0.46 9.2 0.0 3.0 4 0 0 4 4 4 0 FAD binding domain Lycopene_cycl PF05834.7 ESS68351.1 - 0.044 12.6 0.0 31 3.3 0.0 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein GIDA PF01134.17 ESS68351.1 - 0.061 12.1 0.7 3.7 6.3 0.0 3.1 3 0 0 3 3 3 0 Glucose inhibited division protein A Pribosyltran_N PF13793.1 ESS68352.1 - 5.2e-40 135.7 0.2 1.5e-38 131.1 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESS68352.1 - 3.9e-27 95.1 7.0 1e-26 93.7 1.0 2.7 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ESS68352.1 - 2.7e-13 49.7 0.1 6.1e-13 48.5 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESS68352.1 - 6.9e-05 22.1 0.1 0.00013 21.2 0.0 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase BCS1_N PF08740.6 ESS68353.1 - 2.2e-39 134.9 1.0 3e-39 134.5 0.7 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 ESS68353.1 - 2e-09 37.7 0.0 4.7e-09 36.5 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESS68353.1 - 0.046 13.4 0.0 0.16 11.7 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain AAA_11 PF13086.1 ESS68353.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESS68353.1 - 0.079 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AIRS_C PF02769.17 ESS68354.1 - 3.6e-14 53.0 0.0 7.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 ESS68354.1 - 2.7e-07 30.7 0.0 5.1e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain KH_1 PF00013.24 ESS68355.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 KH domain Pup PF05639.6 ESS68355.1 - 0.041 14.3 0.5 0.59 10.6 0.0 2.4 2 0 0 2 2 2 0 Pup-like protein KH_3 PF13014.1 ESS68355.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 KH domain TylF PF05711.6 ESS68356.1 - 1.2e-33 116.2 0.1 1.6e-33 115.8 0.1 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 ESS68356.1 - 1.1e-11 45.4 0.0 2.9e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CmcI PF04989.7 ESS68356.1 - 0.0067 15.7 0.0 0.1 11.8 0.0 2.4 3 0 0 3 3 3 1 Cephalosporin hydroxylase SEP PF08059.8 ESS68357.1 - 1.3e-05 25.4 0.0 3.5e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 ESS68357.1 - 6.5e-05 22.9 0.0 0.00018 21.5 0.0 1.7 1 0 0 1 1 1 1 UBX domain Laminin_G_3 PF13385.1 ESS68359.1 - 2.8e-07 30.9 0.0 4.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BNR_3 PF13859.1 ESS68360.1 - 3.9e-18 65.5 0.0 4.8e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 ESS68360.1 - 0.00079 18.8 8.6 0.082 12.7 0.1 3.2 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.1 ESS68360.1 - 0.0063 15.8 0.2 0.015 14.6 0.1 1.4 1 1 0 1 1 1 1 BNR repeat-like domain Ribosomal_L25p PF01386.14 ESS68373.1 - 0.2 11.7 2.4 0.43 10.7 0.4 2.4 2 0 0 2 2 2 0 Ribosomal L25p family DDE_Tnp_4 PF13359.1 ESS68373.1 - 0.2 11.2 3.6 0.58 9.7 0.1 2.6 2 0 0 2 2 2 0 DDE superfamily endonuclease Adap_comp_sub PF00928.16 ESS68374.1 - 5.1e-57 192.9 0.0 6.3e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family TIP49 PF06068.8 ESS68375.1 - 3.7e-180 598.8 4.6 5.1e-180 598.4 2.6 1.5 2 0 0 2 2 2 1 TIP49 C-terminus AAA PF00004.24 ESS68375.1 - 1.6e-08 34.8 4.0 4.9e-06 26.7 0.2 3.2 2 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS68375.1 - 6.2e-07 29.6 0.6 0.085 12.9 0.0 3.5 2 1 0 3 3 3 2 AAA domain RuvB_N PF05496.7 ESS68375.1 - 1.4e-06 27.5 1.5 0.0015 17.5 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 ESS68375.1 - 3.3e-06 26.1 0.1 6e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_5 PF07728.9 ESS68375.1 - 6.4e-06 25.9 0.4 0.0013 18.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS68375.1 - 2.7e-05 24.2 0.2 0.00098 19.1 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 ESS68375.1 - 0.00012 21.7 1.2 0.00027 20.6 0.1 2.2 2 0 0 2 2 2 1 Part of AAA domain AAA_25 PF13481.1 ESS68375.1 - 0.00035 20.0 0.1 0.00077 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESS68375.1 - 0.00038 19.6 0.9 0.0093 15.1 0.3 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI KaiC PF06745.8 ESS68375.1 - 0.0035 16.5 0.3 0.0065 15.6 0.2 1.6 1 0 0 1 1 1 1 KaiC Sigma54_activat PF00158.21 ESS68375.1 - 0.0045 16.4 0.1 1.6 8.1 0.1 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 ESS68375.1 - 0.0087 15.6 0.3 0.023 14.3 0.2 1.7 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 ESS68375.1 - 0.011 15.2 0.6 0.41 10.0 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.12 ESS68375.1 - 0.016 14.6 0.4 0.035 13.5 0.3 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 ESS68375.1 - 0.025 14.2 0.0 0.052 13.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.7 ESS68375.1 - 0.026 13.6 0.8 0.071 12.2 0.5 1.7 1 0 0 1 1 1 0 Zeta toxin DUF2075 PF09848.4 ESS68375.1 - 0.033 13.1 0.2 0.056 12.4 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.1 ESS68375.1 - 0.034 14.1 0.2 0.075 12.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain SUV3_C PF12513.3 ESS68376.1 - 1.3e-14 53.3 1.9 2.5e-14 52.4 0.7 2.1 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 ESS68376.1 - 4.2e-09 36.1 0.0 9.2e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS68376.1 - 0.0053 16.2 0.0 0.018 14.5 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Kinesin PF00225.18 ESS68376.1 - 0.019 13.6 0.0 0.037 12.7 0.0 1.4 1 0 0 1 1 1 0 Kinesin motor domain Hydrolase PF00702.21 ESS68377.1 - 2.2e-16 60.9 0.2 6.9e-10 39.7 0.2 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESS68377.1 - 2.1e-14 54.1 0.9 1.9e-11 44.4 0.6 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS68377.1 - 1.1e-06 28.4 0.0 2.5e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 ESS68377.1 - 0.00012 21.1 0.7 0.00044 19.3 0.5 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.7 ESS68377.1 - 0.00048 19.7 0.2 0.0018 17.8 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESS68377.1 - 0.091 12.9 0.0 0.25 11.5 0.0 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF21 PF01595.15 ESS68379.1 - 3.8e-32 111.0 0.6 7.2e-32 110.1 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESS68379.1 - 4.8e-08 32.6 0.2 0.00036 20.2 0.1 2.4 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.24 ESS68379.1 - 0.00062 19.5 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Vps52 PF04129.7 ESS68381.1 - 1.1e-15 57.2 1.9 1.8e-15 56.4 1.3 1.3 1 0 0 1 1 1 1 Vps52 / Sac2 family FAD_binding_1 PF00667.15 ESS68383.1 - 3.7e-35 121.3 0.0 5.2e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 ESS68383.1 - 5.1e-22 78.4 0.0 1e-21 77.4 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 ESS68383.1 - 3.5e-17 62.9 0.0 6.6e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain WD40 PF00400.27 ESS68384.1 - 7e-27 92.2 0.3 2e-06 27.4 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESS68384.1 - 0.097 12.4 0.0 8.8 6.1 0.0 3.0 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Pox_P4A PF03395.9 ESS68385.1 - 0.32 8.4 0.1 0.43 8.0 0.1 1.0 1 0 0 1 1 1 0 Poxvirus P4A protein MFS_1 PF07690.11 ESS68387.1 - 2.4e-21 75.8 54.6 2.6e-17 62.5 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 ESS68387.1 - 0.0067 14.8 34.1 0.043 12.2 5.2 3.9 2 2 1 3 3 3 3 MFS/sugar transport protein Acylphosphatase PF00708.13 ESS68388.1 - 0.033 14.2 0.0 0.59 10.2 0.0 2.3 2 0 0 2 2 2 0 Acylphosphatase Methyltransf_11 PF08241.7 ESS68390.1 - 5.5e-10 39.5 0.0 2.2e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain WBS_methylT PF12589.3 ESS68390.1 - 1.5e-09 38.2 7.8 1.5e-09 38.2 5.4 2.4 3 0 0 3 3 3 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_31 PF13847.1 ESS68390.1 - 6.6e-07 29.0 0.0 1.4e-05 24.7 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS68390.1 - 1e-06 29.0 0.0 8.8e-06 26.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS68390.1 - 1.5e-06 28.0 0.1 2.9e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS68390.1 - 2.3e-05 24.8 0.0 0.00032 21.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS68390.1 - 8.3e-05 22.5 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS68390.1 - 0.00022 21.7 0.1 0.0004 20.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESS68390.1 - 0.00057 19.4 0.0 0.00089 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 ESS68390.1 - 0.01 14.9 0.0 0.023 13.8 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase N6_N4_Mtase PF01555.13 ESS68390.1 - 0.11 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 DNA methylase NOA36 PF06524.7 ESS68390.1 - 0.13 11.4 3.0 0.4 9.8 1.4 1.9 2 0 0 2 2 2 0 NOA36 protein Metallophos PF00149.23 ESS68392.1 - 2.5e-21 75.9 0.0 7.8e-21 74.3 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_M14 PF00246.19 ESS68395.1 - 6e-15 55.6 0.0 7.8e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESS68395.1 - 0.00032 19.6 0.1 0.00049 19.0 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family cNMP_binding PF00027.24 ESS68396.1 - 1.7e-27 95.0 0.8 1.2e-12 47.4 0.1 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain GTP_EFTU PF00009.22 ESS68397.1 - 2.4e-30 105.3 0.5 3.7e-30 104.7 0.1 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESS68397.1 - 4.3e-08 33.1 0.0 9.8e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESS68397.1 - 2e-07 31.0 0.3 5.4e-07 29.6 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 ESS68397.1 - 0.0002 20.8 0.6 0.2 11.1 0.1 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation GTP_EFTU_D4 PF14578.1 ESS68397.1 - 0.0044 16.6 1.2 0.0087 15.6 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 4 SRPRB PF09439.5 ESS68397.1 - 0.0046 16.1 0.0 0.021 14.0 0.0 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 ESS68397.1 - 0.05 14.1 0.0 0.17 12.4 0.0 2.0 1 1 0 1 1 1 0 Miro-like protein Arf PF00025.16 ESS68397.1 - 0.13 11.4 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family Hexapep PF00132.19 ESS68398.1 - 2.3e-12 45.7 6.6 4.6e-07 29.0 0.0 3.1 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESS68398.1 - 0.00017 21.0 3.4 0.017 14.6 0.2 2.7 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Methyltransf_4 PF02390.12 ESS68398.1 - 0.034 13.1 0.0 0.056 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Mito_fiss_reg PF05308.6 ESS68399.1 - 0.0051 16.2 2.2 0.0083 15.5 1.5 1.4 1 0 0 1 1 1 1 Mitochondrial fission regulator DUF1399 PF07173.7 ESS68399.1 - 0.019 15.2 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1399) Sec2p PF06428.6 ESS68399.1 - 0.031 14.1 1.0 0.056 13.2 0.1 1.8 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p FliJ PF02050.11 ESS68399.1 - 0.13 12.3 0.2 0.13 12.3 0.2 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein DUF745 PF05335.8 ESS68399.1 - 0.14 11.6 1.2 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Syntaxin-6_N PF09177.6 ESS68399.1 - 0.54 10.6 4.9 7.1 7.1 0.3 3.0 2 2 0 2 2 2 0 Syntaxin 6, N-terminal Ribosomal_L3 PF00297.17 ESS68400.1 - 1.4e-100 336.0 7.8 1.8e-100 335.7 5.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Patatin PF01734.17 ESS68401.1 - 6.4e-10 39.3 1.9 1.1e-08 35.3 1.3 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase Y_phosphatase3 PF13350.1 ESS68402.1 - 9e-06 26.0 0.0 1.8e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESS68402.1 - 9.4e-06 25.1 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESS68402.1 - 2.4e-05 24.4 0.1 5.9e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.15 ESS68402.1 - 0.00014 21.4 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.8 ESS68402.1 - 0.0059 15.9 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PDZ_2 PF13180.1 ESS68404.1 - 6.5e-08 32.3 0.0 1.8e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 ESS68404.1 - 0.0047 17.0 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) ACR_tran PF00873.14 ESS68404.1 - 0.055 10.8 0.3 0.073 10.4 0.2 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family EF-hand_7 PF13499.1 ESS68405.1 - 2e-16 59.8 0.2 2e-08 34.2 0.0 4.5 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.1 ESS68405.1 - 5.7e-07 29.0 0.2 7.7e-06 25.4 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS68405.1 - 4.3e-05 23.0 0.1 0.15 12.0 0.0 4.5 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.27 ESS68405.1 - 0.00013 21.0 0.4 0.04 13.2 0.0 4.3 5 0 0 5 5 5 1 EF hand EF-hand_5 PF13202.1 ESS68405.1 - 0.042 13.1 0.0 12 5.4 0.0 3.5 3 0 0 3 3 3 0 EF hand NDK PF00334.14 ESS68406.1 - 1.2e-20 73.6 0.0 4.3e-20 71.8 0.0 1.9 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Rhodanese PF00581.15 ESS68407.1 - 3.2e-11 43.5 0.0 5.9e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.20 ESS68408.1 - 2.1e-22 79.5 0.0 5.4e-22 78.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESS68408.1 - 0.00086 19.1 0.1 0.01 15.5 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Mito_carr PF00153.22 ESS68409.1 - 5.4e-59 195.9 5.4 7e-22 76.9 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UAA PF08449.6 ESS68411.1 - 9.3e-07 28.0 27.0 6.6e-05 21.9 6.6 2.0 2 0 0 2 2 2 2 UAA transporter family TPT PF03151.11 ESS68411.1 - 1.3e-06 28.1 12.2 1.3e-06 28.1 8.4 3.2 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESS68411.1 - 1.7e-05 24.8 30.5 0.0015 18.5 9.6 2.5 2 0 0 2 2 2 2 EamA-like transporter family DNA_pol_A_exo1 PF01612.15 ESS68412.1 - 1.9e-40 138.2 0.4 2.9e-40 137.5 0.3 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.7 ESS68412.1 - 3.1e-24 85.0 0.0 8.1e-24 83.7 0.0 1.7 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.18 ESS68412.1 - 1.1e-10 41.0 0.0 2.5e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 HRDC domain PIP5K PF01504.13 ESS68413.1 - 4e-70 235.8 0.0 5.4e-70 235.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Porin_3 PF01459.17 ESS68414.1 - 0.03 13.6 0.0 0.091 12.0 0.0 1.5 1 1 0 1 1 1 0 Eukaryotic porin AAA_33 PF13671.1 ESS68415.1 - 2e-09 37.4 0.0 3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESS68415.1 - 2.5e-07 30.1 0.0 3.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 ESS68415.1 - 5.2e-05 22.4 0.0 0.00041 19.5 0.0 2.3 2 1 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 ESS68415.1 - 0.00023 21.1 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 ESS68415.1 - 0.00038 20.2 0.0 0.0006 19.5 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ESS68415.1 - 0.00092 19.1 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS68415.1 - 0.0013 19.5 0.4 0.002 18.9 0.0 1.6 2 0 0 2 2 1 1 AAA domain cobW PF02492.14 ESS68415.1 - 0.002 17.6 0.0 0.0032 16.9 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 ESS68415.1 - 0.0045 17.1 0.0 0.0079 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain G-alpha PF00503.15 ESS68415.1 - 0.0063 15.2 0.2 0.0085 14.8 0.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit AAA_24 PF13479.1 ESS68415.1 - 0.0063 16.1 0.0 0.0095 15.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 ESS68415.1 - 0.0099 15.4 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA PF00004.24 ESS68415.1 - 0.021 15.0 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 ESS68415.1 - 0.036 12.9 0.0 0.066 12.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.9 ESS68415.1 - 0.04 13.6 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS68415.1 - 0.066 12.9 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain ATP_bind_1 PF03029.12 ESS68415.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.1 ESS68415.1 - 3.3 8.0 5.9 0.28 11.4 0.3 2.1 2 1 0 2 2 2 0 AAA domain CesT PF05932.8 ESS68419.1 - 1.6e-15 56.9 0.2 3.5e-15 55.8 0.1 1.6 1 0 0 1 1 1 1 Tir chaperone protein (CesT) family ubiquitin PF00240.18 ESS68419.1 - 2.8e-07 29.8 2.6 4.6e-07 29.1 0.0 2.4 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.3 ESS68419.1 - 0.00014 21.4 0.0 0.00038 20.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2756 PF10956.3 ESS68419.1 - 6.9 6.9 12.2 1.2 9.4 5.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) Epimerase PF01370.16 ESS68421.1 - 3.6e-17 62.5 0.0 6.1e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESS68421.1 - 1e-12 48.4 0.0 2.1e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESS68421.1 - 4.6e-08 32.1 0.0 1.4e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 ESS68421.1 - 6e-07 28.9 0.0 1.4e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family Saccharop_dh PF03435.13 ESS68421.1 - 1.7e-05 24.0 0.0 2.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase adh_short PF00106.20 ESS68421.1 - 0.021 14.7 0.0 0.05 13.5 0.0 1.6 2 0 0 2 2 2 0 short chain dehydrogenase KR PF08659.5 ESS68421.1 - 0.087 12.4 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 KR domain DUF3742 PF12553.3 ESS68421.1 - 0.16 12.4 0.8 0.36 11.3 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) E1-E2_ATPase PF00122.15 ESS68423.1 - 3.6e-22 78.5 0.0 9e-22 77.2 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 ESS68423.1 - 6.6e-10 39.4 0.0 1.5e-09 38.3 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESS68423.1 - 2.8e-09 37.6 0.0 3.1e-08 34.3 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS68423.1 - 5.8e-08 32.5 0.0 1.5e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESS68423.1 - 0.008 15.7 0.0 0.022 14.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase dsrm PF00035.20 ESS68424.1 - 1e-14 54.8 0.0 3.1e-08 34.0 0.0 4.9 4 0 0 4 4 4 1 Double-stranded RNA binding motif HA2 PF04408.18 ESS68424.1 - 5.2e-14 52.1 0.1 1.4e-13 50.7 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS68424.1 - 9.6e-11 41.4 0.1 5.7e-10 38.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS68424.1 - 1.8e-09 37.3 0.0 4.2e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS68424.1 - 3.8e-07 30.3 0.1 1.4e-06 28.4 0.1 2.1 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESS68424.1 - 0.00033 19.6 0.0 0.00089 18.2 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein DND1_DSRM PF14709.1 ESS68424.1 - 0.0058 16.8 0.0 0.017 15.3 0.0 1.9 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_19 PF13245.1 ESS68424.1 - 0.0063 16.2 0.1 0.055 13.2 0.1 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 ESS68424.1 - 0.0066 16.3 0.7 0.2 11.5 0.2 3.1 2 1 0 2 2 2 1 AAA domain KaiC PF06745.8 ESS68424.1 - 0.01 14.9 0.0 0.023 13.8 0.0 1.5 1 0 0 1 1 1 0 KaiC PhoH PF02562.11 ESS68424.1 - 0.13 11.4 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein OB_NTP_bind PF07717.11 ESS68425.1 - 0.00022 21.0 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold FixQ PF05545.6 ESS68426.1 - 0.028 14.0 0.7 0.028 14.0 0.5 4.4 6 0 0 6 6 6 0 Cbb3-type cytochrome oxidase component FixQ DRMBL PF07522.9 ESS68427.1 - 1e-17 64.1 0.0 2.3e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 ESS68427.1 - 8.9e-11 41.6 0.0 2.1e-10 40.5 0.1 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESS68427.1 - 8.9e-06 25.4 0.0 1.8e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Thiolase_N PF00108.18 ESS68428.1 - 2.4e-59 200.4 0.0 3.2e-59 200.0 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 ESS68428.1 - 1.2e-33 115.1 0.1 2.4e-33 114.1 0.1 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 ESS68428.1 - 0.00095 18.7 0.3 0.0031 17.0 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain zf-TRM13_CCCH PF11722.3 ESS68429.1 - 0.64 9.4 6.9 1.7 8.1 4.8 1.7 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein DUF2628 PF10947.3 ESS68430.1 - 2.6 7.8 5.2 4.2 7.2 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) zf-UBP PF02148.14 ESS68431.1 - 2.3e-17 62.8 5.8 7.5e-17 61.2 4.0 1.9 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein LRR_4 PF12799.2 ESS68433.1 - 6.2e-06 25.7 2.1 0.32 10.6 0.0 4.0 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESS68433.1 - 1.3e-05 24.7 8.4 0.52 10.5 0.1 4.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.1 ESS68433.1 - 0.0019 17.8 7.3 0.046 13.4 0.5 3.6 1 1 2 3 3 3 2 Leucine rich repeat LRR_7 PF13504.1 ESS68433.1 - 0.0049 16.8 7.3 48 4.8 0.0 5.3 5 0 0 5 5 5 0 Leucine rich repeat LRR_1 PF00560.28 ESS68433.1 - 0.0097 15.8 11.5 7.1 7.0 0.1 5.3 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_2 PF07723.8 ESS68433.1 - 0.37 11.3 6.5 15 6.2 0.2 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat SelB-wing_1 PF09105.5 ESS68434.1 - 0.15 11.7 0.2 0.53 9.9 0.0 1.9 2 0 0 2 2 2 0 Elongation factor SelB, winged helix AAA PF00004.24 ESS68435.1 - 2.6e-36 124.7 0.0 4.1e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESS68435.1 - 3.6e-08 33.1 0.2 1.6e-07 31.0 0.1 2.2 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.9 ESS68435.1 - 5.2e-06 26.2 0.0 4.7e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESS68435.1 - 0.00013 21.0 0.0 0.00055 19.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESS68435.1 - 0.00092 18.9 0.0 0.0024 17.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 ESS68435.1 - 0.0013 18.2 0.0 0.0032 16.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS68435.1 - 0.0015 19.3 0.1 0.0038 18.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS68435.1 - 0.0024 17.8 0.2 0.0098 15.8 0.0 2.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 ESS68435.1 - 0.0025 17.9 0.0 0.017 15.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 ESS68435.1 - 0.0031 17.1 0.0 2.4 7.7 0.0 2.4 1 1 1 2 2 2 2 NACHT domain IstB_IS21 PF01695.12 ESS68435.1 - 0.0033 16.8 0.0 0.0061 15.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 ESS68435.1 - 0.0038 17.0 0.0 0.0079 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 ESS68435.1 - 0.0077 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.16 ESS68435.1 - 0.013 14.7 0.0 0.027 13.6 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESS68435.1 - 0.013 14.2 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus ABC_tran PF00005.22 ESS68435.1 - 0.014 15.6 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.1 ESS68435.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.9 ESS68435.1 - 0.017 15.0 0.0 0.061 13.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 ESS68435.1 - 0.02 13.8 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.11 ESS68435.1 - 0.025 13.8 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 ESS68435.1 - 0.058 12.5 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.1 ESS68435.1 - 0.14 11.7 0.1 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain VPS9 PF02204.13 ESS68436.1 - 1.4e-07 31.4 0.2 5.8e-06 26.2 0.0 3.1 3 1 0 3 3 3 1 Vacuolar sorting protein 9 (VPS9) domain Peptidase_A8 PF01252.13 ESS68436.1 - 0.028 14.0 0.1 0.05 13.2 0.1 1.4 1 0 0 1 1 1 0 Signal peptidase (SPase) II SKG6 PF08693.5 ESS68437.1 - 0.21 10.9 4.5 0.47 9.8 3.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Aldose_epim PF01263.15 ESS68438.1 - 1.9e-42 145.3 0.1 2.7e-42 144.9 0.1 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase Leucyl-specific PF14795.1 ESS68438.1 - 0.038 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Leucine-tRNA synthetase-specific domain HECT PF00632.20 ESS68439.1 - 5.2e-12 45.5 0.0 0.046 12.8 0.0 5.2 4 1 1 5 5 5 5 HECT-domain (ubiquitin-transferase) Lactamase_B PF00753.22 ESS68440.1 - 5.3e-13 49.0 0.5 1.2e-12 47.9 0.4 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Beta-Casp PF10996.3 ESS68441.1 - 6e-33 113.4 0.0 1.7e-32 112.0 0.0 1.8 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 ESS68441.1 - 4.1e-20 72.2 0.0 6.9e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESS68441.1 - 2.5e-10 40.2 0.1 6.6e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 ESS68441.1 - 1.9e-09 37.1 0.1 3.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase CPSF73-100_C PF11718.3 ESS68441.1 - 2.1e-09 37.0 0.2 4.5e-09 35.9 0.1 1.6 2 0 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_3 PF13483.1 ESS68441.1 - 6.1e-05 22.7 0.0 0.00016 21.4 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Topoisom_I_N PF02919.10 ESS68442.1 - 4.6e-95 316.9 2.5 4.6e-95 316.9 1.7 3.0 2 1 1 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 ESS68442.1 - 1.5e-81 272.9 0.9 1.5e-81 272.9 0.6 1.6 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core DUF2201_N PF13203.1 ESS68442.1 - 0.7 9.0 13.6 1.4 7.9 9.4 1.5 1 0 0 1 1 1 0 Putative metallopeptidase domain Dsh_C PF12316.3 ESS68442.1 - 7.9 6.5 13.6 17 5.4 9.4 1.6 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal LRR_8 PF13855.1 ESS68443.1 - 8e-05 22.3 1.7 8e-05 22.3 1.2 2.6 3 0 0 3 3 3 1 Leucine rich repeat LRR_9 PF14580.1 ESS68443.1 - 0.00021 20.9 0.1 0.00056 19.5 0.1 1.7 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 ESS68443.1 - 0.0024 17.4 8.5 0.0029 17.2 1.1 4.1 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) DUF4337 PF14235.1 ESS68443.1 - 0.23 11.2 0.1 0.8 9.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) LRR_1 PF00560.28 ESS68443.1 - 0.45 10.7 4.5 16 6.0 0.0 4.2 3 1 0 3 3 3 0 Leucine Rich Repeat zf-RanBP PF00641.13 ESS68444.1 - 0.00017 20.6 2.5 0.00032 19.7 1.7 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Amidinotransf PF02274.12 ESS68445.1 - 8e-13 48.1 0.0 3.2e-12 46.1 0.0 2.0 1 1 0 1 1 1 1 Amidinotransferase TPR_12 PF13424.1 ESS68446.1 - 1.2e-42 143.7 47.7 8.1e-16 57.7 0.5 5.2 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.1 ESS68446.1 - 1.8e-21 75.3 26.0 5.6e-08 32.4 0.0 7.2 7 1 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.1 ESS68446.1 - 1.1e-12 46.7 13.6 0.00011 21.7 0.1 6.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS68446.1 - 1e-07 31.4 22.5 0.0004 19.9 0.6 5.4 2 2 4 6 6 6 3 TPR repeat TPR_7 PF13176.1 ESS68446.1 - 1.5e-05 24.4 17.9 0.0007 19.2 0.1 6.0 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS68446.1 - 0.00061 19.7 7.6 1.1 9.6 0.0 5.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68446.1 - 0.0028 18.1 18.3 0.66 10.7 0.0 7.3 6 1 2 8 8 8 1 Tetratricopeptide repeat Rapsyn_N PF10579.4 ESS68446.1 - 0.0079 15.9 5.2 8.8 6.2 0.0 4.2 3 1 2 5 5 5 1 Rapsyn N-terminal myristoylation and linker region TPR_1 PF00515.23 ESS68446.1 - 0.023 14.2 17.2 0.1 12.2 0.0 6.4 8 1 0 8 8 7 0 Tetratricopeptide repeat PHR PF08005.7 ESS68446.1 - 0.049 13.8 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 PHR domain DUF2924 PF11149.3 ESS68446.1 - 0.077 13.0 0.4 0.21 11.5 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2924) TPR_19 PF14559.1 ESS68446.1 - 0.14 12.5 2.6 0.54 10.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68446.1 - 0.15 12.0 23.1 0.57 10.2 0.1 6.4 7 2 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68446.1 - 0.24 12.1 15.9 1.7 9.4 0.1 5.6 2 2 3 6 6 6 0 Tetratricopeptide repeat OEP PF02321.13 ESS68446.1 - 1.8 8.1 9.4 0.85 9.1 1.1 3.0 2 1 1 3 3 3 0 Outer membrane efflux protein TIP49 PF06068.8 ESS68447.1 - 5.6e-186 618.0 1.5 6.5e-186 617.8 1.1 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 ESS68447.1 - 5.2e-12 46.1 1.2 3.9e-07 30.3 0.0 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS68447.1 - 2.4e-11 43.1 0.6 1e-07 31.2 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESS68447.1 - 9.9e-07 28.9 0.1 0.043 13.9 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESS68447.1 - 2.1e-06 27.8 0.0 0.00062 19.8 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESS68447.1 - 0.00058 19.5 0.1 0.093 12.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS68447.1 - 0.00081 18.6 0.2 0.047 12.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESS68447.1 - 0.001 18.8 0.1 0.0041 16.8 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_25 PF13481.1 ESS68447.1 - 0.0016 17.8 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESS68447.1 - 0.0045 16.4 0.4 0.029 13.7 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.1 ESS68447.1 - 0.0047 16.7 0.1 0.017 15.0 0.0 2.0 3 0 0 3 3 1 1 AAA domain AAA_14 PF13173.1 ESS68447.1 - 0.0054 16.6 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESS68447.1 - 0.0073 16.2 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS68447.1 - 0.0073 17.1 0.0 0.024 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESS68447.1 - 0.017 15.4 0.3 0.13 12.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_11 PF13086.1 ESS68447.1 - 0.038 13.5 0.2 0.094 12.2 0.1 1.8 2 1 0 2 2 1 0 AAA domain ResIII PF04851.10 ESS68447.1 - 0.073 12.8 1.2 3.8 7.2 0.0 2.4 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.7 ESS68447.1 - 0.082 11.9 0.2 0.22 10.5 0.1 1.7 1 0 0 1 1 1 0 Zeta toxin SET PF00856.23 ESS68448.1 - 9e-06 26.0 0.0 5.6e-05 23.5 0.0 2.0 1 1 0 1 1 1 1 SET domain AAA PF00004.24 ESS68449.1 - 8e-51 171.6 0.0 1.4e-37 128.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS68449.1 - 1.6e-11 44.5 5.9 0.00018 21.5 0.0 4.1 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 ESS68449.1 - 2.5e-09 37.3 1.0 0.004 17.2 0.0 3.3 2 2 1 3 3 2 2 AAA domain Arch_ATPase PF01637.13 ESS68449.1 - 4.1e-09 36.4 0.0 0.0053 16.4 0.0 3.6 3 1 1 4 4 3 2 Archaeal ATPase NACHT PF05729.7 ESS68449.1 - 7.6e-09 35.4 0.9 0.14 11.7 0.0 4.0 2 2 1 3 3 3 3 NACHT domain AAA_25 PF13481.1 ESS68449.1 - 1.1e-08 34.7 2.5 0.081 12.3 0.0 4.5 3 1 1 4 4 4 3 AAA domain AAA_5 PF07728.9 ESS68449.1 - 4.6e-08 32.8 0.0 0.0065 16.1 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESS68449.1 - 4.9e-07 29.7 0.0 0.0044 16.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 ESS68449.1 - 1.3e-06 28.2 0.0 0.002 18.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.8 ESS68449.1 - 4.6e-06 25.7 0.0 0.0022 16.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.22 ESS68449.1 - 5.3e-06 26.7 1.2 0.27 11.5 0.0 3.6 2 1 0 3 3 3 1 ABC transporter Sigma54_activ_2 PF14532.1 ESS68449.1 - 5.5e-06 26.4 0.0 0.01 15.9 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.1 ESS68449.1 - 8.2e-06 25.8 0.0 0.04 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 ESS68449.1 - 1.8e-05 23.7 0.1 0.048 12.5 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein RNA_helicase PF00910.17 ESS68449.1 - 1.9e-05 24.8 0.0 0.019 15.1 0.0 2.8 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.12 ESS68449.1 - 2e-05 24.0 1.0 0.026 13.9 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_2 PF07724.9 ESS68449.1 - 2.3e-05 24.3 0.0 0.00042 20.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 ESS68449.1 - 5.3e-05 22.8 2.3 0.3 10.8 1.4 3.3 2 1 0 2 2 2 2 Part of AAA domain ATP-synt_ab PF00006.20 ESS68449.1 - 0.00015 21.3 0.6 0.32 10.4 0.0 2.7 2 1 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_17 PF13207.1 ESS68449.1 - 0.00032 21.5 1.1 0.029 15.1 0.0 3.1 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESS68449.1 - 0.00036 19.9 0.5 0.5 9.9 0.1 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain PEX-1N PF09262.6 ESS68449.1 - 0.00052 20.0 0.1 0.0012 18.8 0.0 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal Zeta_toxin PF06414.7 ESS68449.1 - 0.00059 18.9 0.0 0.59 9.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Bac_DnaA PF00308.13 ESS68449.1 - 0.0008 19.1 0.1 1.4 8.5 0.0 3.4 3 0 0 3 3 3 1 Bacterial dnaA protein DUF258 PF03193.11 ESS68449.1 - 0.00096 18.3 0.2 0.11 11.6 0.0 2.6 3 0 0 3 3 2 1 Protein of unknown function, DUF258 Vps4_C PF09336.5 ESS68449.1 - 0.0011 18.7 0.2 0.0041 16.9 0.0 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain Miro PF08477.8 ESS68449.1 - 0.0015 18.9 0.1 0.11 13.0 0.1 3.1 3 1 0 3 3 2 1 Miro-like protein cobW PF02492.14 ESS68449.1 - 0.0018 17.7 1.9 2.5 7.5 0.0 3.3 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.16 ESS68449.1 - 0.0021 17.2 0.3 2 7.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI MobB PF03205.9 ESS68449.1 - 0.0035 17.0 0.9 0.71 9.5 0.3 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.10 ESS68449.1 - 0.0067 15.1 0.1 0.22 10.1 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein NTPase_1 PF03266.10 ESS68449.1 - 0.0089 15.7 0.4 2.6 7.7 0.0 3.0 3 0 0 3 3 2 1 NTPase UPF0079 PF02367.12 ESS68449.1 - 0.009 15.6 0.3 2.4 7.8 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_10 PF12846.2 ESS68449.1 - 0.01 15.3 0.1 2 7.7 0.0 2.5 2 0 0 2 2 2 1 AAA-like domain FtsK_SpoIIIE PF01580.13 ESS68449.1 - 0.013 14.9 1.3 7.5 5.9 0.1 3.9 4 0 0 4 4 4 0 FtsK/SpoIIIE family NB-ARC PF00931.17 ESS68449.1 - 0.032 13.1 0.0 6.9 5.4 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.21 ESS68449.1 - 0.032 13.7 0.1 9 5.7 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain PduV-EutP PF10662.4 ESS68449.1 - 0.034 13.6 0.1 12 5.4 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.7 ESS68449.1 - 0.035 13.1 0.0 1.7 7.6 0.0 2.6 3 0 0 3 3 2 0 Holliday junction DNA helicase ruvB N-terminus DAP3 PF10236.4 ESS68449.1 - 0.049 12.5 0.2 1.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.1 ESS68449.1 - 0.08 12.5 0.3 0.54 9.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain PIF1 PF05970.9 ESS68449.1 - 0.13 11.1 0.1 7.7 5.3 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Septin PF00735.13 ESS68449.1 - 0.16 10.9 0.4 10 5.0 0.0 2.2 2 0 0 2 2 2 0 Septin Peptidase_M8 PF01457.11 ESS68450.1 - 1.1e-62 212.1 0.0 1.4e-62 211.7 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M57 PF12388.3 ESS68450.1 - 0.017 14.4 0.1 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Ribosomal_S19e PF01090.14 ESS68451.1 - 4.6e-46 155.7 0.0 5.7e-46 155.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19e Mrr_N PF14338.1 ESS68451.1 - 0.065 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Mrr N-terminal domain LRR_6 PF13516.1 ESS68452.1 - 7.6e-05 22.3 0.0 0.076 13.1 0.0 3.0 2 0 0 2 2 2 2 Leucine Rich repeat DUF4530 PF15039.1 ESS68452.1 - 0.034 14.0 1.1 0.052 13.4 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Nucleoplasmin PF03066.10 ESS68452.1 - 0.043 13.3 2.3 0.15 11.5 1.8 1.7 2 0 0 2 2 2 0 Nucleoplasmin LRR_4 PF12799.2 ESS68452.1 - 0.067 12.8 0.1 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) RRM_1 PF00076.17 ESS68453.1 - 1e-13 50.6 0.3 2.2e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68453.1 - 2.7e-12 46.4 0.0 5.8e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.3 ESS68453.1 - 6.6e-06 26.0 0.4 6.6e-06 26.0 0.3 2.3 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 3 subunit G RRM_5 PF13893.1 ESS68453.1 - 1.9e-05 24.4 0.1 4.4e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.3 ESS68453.1 - 0.013 14.7 0.3 0.061 12.6 0.0 2.1 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated NID PF07292.8 ESS68453.1 - 0.081 12.9 0.9 2.3 8.3 0.0 2.8 3 0 0 3 3 3 0 Nmi/IFP 35 domain (NID) Thioredoxin_9 PF14595.1 ESS68454.1 - 0.074 12.6 1.1 0.1 12.1 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin ADIP PF11559.3 ESS68455.1 - 0.022 14.6 11.6 0.025 14.5 8.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4349 PF14257.1 ESS68455.1 - 0.031 13.4 8.9 0.041 13.1 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Phage_Integr_2 PF13009.1 ESS68455.1 - 0.072 12.0 1.4 0.079 11.8 1.0 1.1 1 0 0 1 1 1 0 Putative phage integrase CAP_N PF01213.14 ESS68455.1 - 0.17 11.1 1.4 0.2 10.9 1.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HU-DNA_bdg PF14848.1 ESS68455.1 - 0.17 11.6 0.9 0.44 10.2 0.1 1.9 2 0 0 2 2 2 0 DNA-binding domain DUF725 PF05267.7 ESS68455.1 - 0.23 11.3 2.0 1.2 9.0 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF725) IncA PF04156.9 ESS68455.1 - 0.26 10.8 17.1 0.35 10.4 11.8 1.2 1 0 0 1 1 1 0 IncA protein DUF1943 PF09172.6 ESS68455.1 - 0.52 9.1 5.4 3.8 6.3 2.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1943) Peptidase_S46 PF10459.4 ESS68455.1 - 0.57 8.5 8.4 0.65 8.3 5.8 1.0 1 0 0 1 1 1 0 Peptidase S46 V_ATPase_I PF01496.14 ESS68455.1 - 6.6 4.4 8.2 7.8 4.2 5.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2664 PF10867.3 ESS68455.1 - 7.6 7.2 12.6 16 6.2 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2664) FUSC PF04632.7 ESS68455.1 - 8.4 4.6 6.3 9.3 4.5 4.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ACBP PF00887.14 ESS68456.1 - 1.5e-21 75.8 0.7 1.6e-21 75.7 0.5 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein WW PF00397.21 ESS68457.1 - 0.0001 22.0 4.6 0.00021 21.0 3.2 1.5 1 0 0 1 1 1 1 WW domain eIF3g PF12353.3 ESS68457.1 - 0.00017 21.5 1.0 0.00017 21.5 0.7 3.2 1 1 2 3 3 3 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 ESS68457.1 - 0.005 16.6 2.5 0.005 16.6 1.8 3.3 4 0 0 4 4 4 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESS68457.1 - 0.096 12.2 0.5 0.096 12.2 0.3 3.0 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.1 ESS68457.1 - 8 6.2 9.6 19 5.1 3.5 2.6 2 0 0 2 2 2 0 Zinc knuckle Pap_E4 PF02711.9 ESS68457.1 - 9.7 7.0 14.3 3.5 8.5 0.7 3.2 1 1 2 3 3 3 0 E4 protein Urm1 PF09138.6 ESS68458.1 - 1.1e-30 105.5 0.0 1.2e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 ESS68458.1 - 1.5e-06 28.5 0.0 1.8e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 ThiS family TGS PF02824.16 ESS68458.1 - 0.069 12.9 0.1 0.16 11.8 0.1 1.6 2 0 0 2 2 2 0 TGS domain Ribosomal_L33 PF00471.15 ESS68459.1 - 0.096 12.9 0.1 0.17 12.1 0.1 1.6 1 1 0 1 1 1 0 Ribosomal protein L33 Beta_helix PF13229.1 ESS68460.1 - 6.5e-06 25.9 0.0 0.0017 18.1 0.0 3.1 2 1 0 3 3 3 1 Right handed beta helix region NosD PF05048.8 ESS68460.1 - 4.2e-05 22.8 0.0 0.00024 20.3 0.0 2.0 2 0 0 2 2 2 1 Periplasmic copper-binding protein (NosD) Pentapeptide_3 PF13576.1 ESS68460.1 - 0.24 11.3 1.1 1.8 8.5 0.2 2.7 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.1 ESS68460.1 - 1.3 8.8 5.6 0.5 10.2 0.7 2.6 3 1 0 3 3 3 0 Pentapeptide repeats (9 copies) Cyt-b5 PF00173.23 ESS68461.1 - 5.2e-11 42.1 0.1 7.6e-11 41.6 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Toxin_54 PF15533.1 ESS68461.1 - 0.13 12.4 0.1 0.3 11.3 0.0 1.6 2 0 0 2 2 2 0 Putative toxin 54 RVT_1 PF00078.22 ESS68498.1 - 1.4e-19 70.3 0.0 1.9e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tup_N PF08581.5 ESS68500.1 - 1.1e-06 28.7 16.7 0.29 11.3 0.0 4.9 4 1 1 5 5 5 3 Tup N-terminal Fib_alpha PF08702.5 ESS68500.1 - 4.3e-05 23.6 6.8 0.00066 19.8 0.1 3.6 2 1 0 3 3 3 1 Fibrinogen alpha/beta chain family Vps51 PF08700.6 ESS68500.1 - 0.021 14.6 1.8 26 4.7 0.0 4.0 4 0 0 4 4 4 0 Vps51/Vps67 DUF1474 PF07342.6 ESS68500.1 - 0.072 13.3 1.9 0.12 12.6 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) LOH1CR12 PF10158.4 ESS68500.1 - 0.2 11.4 3.4 16 5.2 0.1 3.1 3 1 0 3 3 3 0 Tumour suppressor protein TBPIP PF07106.8 ESS68500.1 - 1.9 8.0 13.9 3.5 7.1 0.0 3.9 3 1 1 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CCDC92 PF14916.1 ESS68500.1 - 2 8.0 9.8 23 4.6 0.1 4.6 5 0 0 5 5 5 0 Coiled-coil domain of unknown function PEP-utilisers_N PF05524.8 ESS68500.1 - 3.2 7.5 9.3 32 4.3 0.1 4.1 3 1 0 4 4 4 0 PEP-utilising enzyme, N-terminal Med9 PF07544.8 ESS68500.1 - 7.8 6.3 10.1 41 3.9 0.1 4.4 5 0 0 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 Prefoldin PF02996.12 ESS68500.1 - 9.7 5.8 11.8 1.1 8.9 0.1 4.1 3 1 1 4 4 4 0 Prefoldin subunit DUF21 PF01595.15 ESS68501.1 - 3e-24 85.3 7.8 4.3e-24 84.8 5.4 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESS68501.1 - 0.011 15.5 0.1 0.025 14.3 0.0 1.7 1 0 0 1 1 1 0 CBS domain LRR_4 PF12799.2 ESS68502.1 - 9e-22 76.2 5.2 4.8e-09 35.6 0.8 3.5 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS68502.1 - 3.9e-11 42.5 23.6 4.7e-05 23.0 2.0 3.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_6 PF13516.1 ESS68502.1 - 3.5e-08 32.6 3.5 0.9 9.8 0.1 5.7 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.28 ESS68502.1 - 6.5e-08 31.5 10.2 4.8 7.5 0.5 6.8 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 ESS68502.1 - 1.1e-05 24.8 6.7 10 6.8 0.1 6.3 6 0 0 6 6 6 2 Leucine rich repeat LRR_9 PF14580.1 ESS68502.1 - 5.4e-05 22.8 0.0 0.00011 21.7 0.0 1.6 1 0 0 1 1 1 1 Leucine-rich repeat MMR_HSR1 PF01926.18 ESS68503.1 - 3.5e-13 49.5 0.0 6.4e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESS68503.1 - 2.8e-05 23.6 0.0 0.0045 16.4 0.0 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESS68503.1 - 4.8e-05 22.6 0.0 8.7e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ESS68503.1 - 0.0097 15.1 0.0 0.039 13.2 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESS68503.1 - 0.1 12.4 0.2 1.2 8.8 0.1 2.3 1 1 1 2 2 2 0 Dynamin family DnaJ PF00226.26 ESS68504.1 - 2e-22 78.6 0.0 4.7e-22 77.4 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain SYF2 PF08231.7 ESS68504.1 - 0.21 11.7 8.1 0.39 10.8 5.6 1.4 1 0 0 1 1 1 0 SYF2 splicing factor Metallophos PF00149.23 ESS68505.1 - 1.6e-37 128.8 0.0 2e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Herpes_UL55 PF04537.7 ESS68505.1 - 0.077 12.3 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus UL55 protein Ras PF00071.17 ESS68506.1 - 2.5e-10 39.9 0.1 5e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS68506.1 - 0.00012 22.5 0.0 0.00033 21.1 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 ESS68506.1 - 0.0018 17.4 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region IBR PF01485.16 ESS68506.1 - 0.031 14.1 0.5 0.13 12.2 0.1 2.2 2 0 0 2 2 2 0 IBR domain SDH_beta PF03315.10 ESS68506.1 - 0.092 12.7 0.1 0.34 10.9 0.0 1.8 1 1 1 2 2 2 0 Serine dehydratase beta chain DUF2346 PF09803.4 ESS68507.1 - 0.079 12.8 0.5 0.23 11.3 0.1 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2346) zf-MIZ PF02891.15 ESS68510.1 - 6.1e-10 38.4 7.6 6.1e-10 38.4 5.3 2.3 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 ESS68510.1 - 2.9e-05 23.4 3.2 7.2e-05 22.2 2.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit ABC_tran PF00005.22 ESS68511.1 - 5.2e-35 120.7 0.0 4e-34 117.8 0.0 2.3 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.18 ESS68511.1 - 3.3e-17 62.7 4.1 4.6e-17 62.3 2.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 ESS68511.1 - 7.2e-08 31.9 0.1 1.6e-05 24.2 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESS68511.1 - 8.4e-07 29.2 0.1 0.0013 18.8 0.0 2.4 1 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESS68511.1 - 0.00063 19.7 0.0 0.0016 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 ESS68511.1 - 0.0014 18.1 1.2 0.0031 17.0 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 ESS68511.1 - 0.0087 16.8 0.1 0.021 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESS68511.1 - 0.019 14.1 0.0 0.048 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_33 PF13671.1 ESS68511.1 - 0.03 14.1 0.0 0.079 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESS68511.1 - 0.052 13.2 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 ESS68511.1 - 0.061 13.6 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESS68511.1 - 0.063 13.4 0.0 0.31 11.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ESS68511.1 - 0.16 11.9 0.0 0.7 9.8 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.1 ESS68511.1 - 0.17 12.1 3.0 0.21 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF904 PF06005.7 ESS68513.1 - 0.0091 16.2 7.4 0.0091 16.2 5.1 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF904) GAS PF13851.1 ESS68513.1 - 3.6 6.7 15.1 0.15 11.2 4.1 2.7 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Filament PF00038.16 ESS68513.1 - 4.2 6.7 20.8 0.44 9.9 0.7 3.3 2 1 1 4 4 4 0 Intermediate filament protein FSH1 PF03959.8 ESS68514.1 - 2e-40 138.5 0.0 1.9e-39 135.3 0.0 2.0 2 0 0 2 2 2 1 Serine hydrolase (FSH1) MMR_HSR1_C PF08438.5 ESS68514.1 - 2.5e-21 75.9 0.0 4.7e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 ESS68514.1 - 2.2e-14 53.4 0.0 4.2e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RWD PF05773.17 ESS68514.1 - 2.5e-07 30.5 0.0 7.8e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 RWD domain Abhydrolase_5 PF12695.2 ESS68514.1 - 2.5e-05 24.0 0.0 6.2e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family FeoB_N PF02421.13 ESS68514.1 - 0.00075 18.8 0.0 0.0048 16.1 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B ATP_bind_1 PF03029.12 ESS68514.1 - 0.22 11.0 0.0 8.4 5.8 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DARPP-32 PF05395.7 ESS68514.1 - 1.1 9.3 5.7 0.066 13.3 0.3 1.5 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 AA_kinase PF00696.23 ESS68515.1 - 1.6e-34 119.5 0.0 3.5e-34 118.4 0.0 1.6 1 0 0 1 1 1 1 Amino acid kinase family Aldedh PF00171.17 ESS68515.1 - 1.7e-17 62.9 0.8 4.4e-13 48.3 0.2 2.3 2 0 0 2 2 2 2 Aldehyde dehydrogenase family PrpR_N PF06506.6 ESS68515.1 - 0.022 14.1 1.2 0.31 10.4 0.2 3.0 2 1 0 2 2 2 0 Propionate catabolism activator IQ PF00612.22 ESS68516.1 - 3.5e-16 57.2 55.6 3.6e-05 23.0 3.0 8.8 8 0 0 8 8 8 7 IQ calmodulin-binding motif TPR_12 PF13424.1 ESS68516.1 - 4.5e-06 26.5 6.6 0.15 11.9 1.2 5.4 3 1 2 5 5 5 3 Tetratricopeptide repeat IQ PF00612.22 ESS68517.1 - 6.6e-07 28.4 19.7 0.014 14.9 0.7 5.0 4 0 0 4 4 4 3 IQ calmodulin-binding motif LRR_6 PF13516.1 ESS68518.1 - 4.8e-10 38.4 2.7 0.015 15.2 0.0 4.6 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 ESS68518.1 - 4e-06 26.3 1.1 0.0023 17.4 0.1 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS68518.1 - 0.0003 20.3 1.5 17 5.9 0.0 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 ESS68518.1 - 0.0089 16.0 0.6 52 4.7 0.0 4.5 4 0 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 ESS68518.1 - 0.091 12.5 0.9 1 9.1 0.1 2.8 3 0 0 3 3 3 0 Leucine rich repeat COG5 PF10392.4 ESS68520.1 - 7.6e-18 64.7 4.7 2.3e-14 53.4 0.1 3.2 3 0 0 3 3 3 2 Golgi transport complex subunit 5 COG2 PF06148.6 ESS68520.1 - 0.0016 18.3 0.0 0.0066 16.3 0.0 2.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Sec5 PF15469.1 ESS68520.1 - 0.16 11.7 1.3 0.38 10.4 0.1 2.3 2 1 1 3 3 3 0 Exocyst complex component Sec5 PIN_2 PF10130.4 ESS68520.1 - 2.5 8.1 6.9 0.38 10.7 0.1 3.0 4 0 0 4 4 4 0 PIN domain Takusan PF04822.8 ESS68521.1 - 0.005 16.5 1.7 0.019 14.7 1.2 2.0 1 0 0 1 1 1 1 Takusan DUF4140 PF13600.1 ESS68521.1 - 0.31 11.5 6.2 3.2 8.2 0.4 2.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4164 PF13747.1 ESS68521.1 - 0.78 9.9 12.8 0.051 13.7 2.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Seryl_tRNA_N PF02403.17 ESS68521.1 - 2.4 8.2 10.2 0.14 12.2 1.1 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.10 ESS68521.1 - 2.9 7.4 8.2 5.2 6.6 1.7 2.7 2 0 0 2 2 2 0 Septum formation initiator TLC PF03219.9 ESS68523.1 - 10 4.4 10.4 13 4.1 7.2 1.2 1 0 0 1 1 1 0 TLC ATP/ADP transporter Pkinase PF00069.20 ESS68526.1 - 0.021 13.9 0.0 0.036 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Dicty_REP PF05086.7 ESS68526.1 - 8.4 4.0 6.5 12 3.5 4.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Bap31 PF05529.7 ESS68527.1 - 2.7 7.4 8.3 4 6.8 4.1 2.0 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Glucosamine_iso PF01182.15 ESS68528.1 - 1.4e-22 80.4 0.0 1.8e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Tetraspannin PF00335.15 ESS68529.1 - 2.6e-14 53.0 9.2 2.6e-14 53.0 6.4 2.0 2 0 0 2 2 2 1 Tetraspanin family APOBEC_C PF05240.9 ESS68529.1 - 0.054 12.8 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 APOBEC-like C-terminal domain UPF0104 PF03706.8 ESS68529.1 - 0.52 9.5 13.5 3.9 6.6 8.5 2.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0104) DUF1625 PF07787.7 ESS68529.1 - 1.3 8.2 5.4 2.5 7.2 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1625) PalH PF08733.5 ESS68529.1 - 7.2 5.3 11.6 1.1 8.0 4.8 1.7 2 0 0 2 2 2 0 PalH/RIM21 Cpn60_TCP1 PF00118.19 ESS68530.1 - 1.7e-136 455.6 4.6 2e-136 455.4 3.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CTDII PF01556.13 ESS68532.1 - 6.8e-22 77.1 0.2 1e-20 73.3 0.0 2.5 3 0 0 3 3 3 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESS68532.1 - 1.2e-15 57.3 17.0 1.9e-15 56.6 11.8 1.3 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 ESS68532.1 - 0.039 13.6 6.6 0.72 9.5 0.5 2.4 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Zn_Tnp_IS1595 PF12760.2 ESS68532.1 - 8.6 6.2 17.1 5.3 6.9 1.6 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain PAAR_motif PF05488.8 ESS68532.1 - 9.5 6.2 11.5 26 4.8 0.9 3.2 1 1 1 2 2 2 0 PAAR motif Pyr_redox_2 PF07992.9 ESS68533.1 - 2.4e-40 138.5 1.6 3.2e-40 138.1 0.7 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ESS68533.1 - 3.2e-39 133.3 0.2 1.8e-38 130.9 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ESS68533.1 - 3.6e-19 68.9 8.3 2.9e-17 62.8 0.5 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESS68533.1 - 8.2e-10 38.3 1.0 8.2e-10 38.3 0.7 2.4 3 1 1 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESS68533.1 - 1.7e-08 34.7 0.1 2.8e-05 24.2 0.1 2.4 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS68533.1 - 2.4e-08 33.2 11.4 1.3e-06 27.5 4.2 3.0 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.19 ESS68533.1 - 4.2e-07 29.1 9.9 1.2e-06 27.6 1.9 2.9 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.1 ESS68533.1 - 4.3e-06 26.6 4.1 0.0027 17.6 0.5 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESS68533.1 - 0.00016 20.8 2.7 0.00064 18.8 0.1 2.6 3 0 0 3 3 3 1 Thi4 family AlaDh_PNT_C PF01262.16 ESS68533.1 - 0.00029 20.4 3.1 0.02 14.4 0.1 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.14 ESS68533.1 - 0.00076 18.6 11.4 0.043 12.8 0.4 3.2 2 1 1 3 3 3 2 FAD binding domain K_oxygenase PF13434.1 ESS68533.1 - 0.0012 17.8 0.4 0.085 11.7 0.0 2.5 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 ESS68533.1 - 0.0012 17.4 1.5 0.0012 17.4 1.0 3.7 3 1 1 4 4 4 1 HI0933-like protein 3HCDH_N PF02737.13 ESS68533.1 - 0.0076 15.9 0.2 0.0076 15.9 0.1 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 ESS68533.1 - 0.025 14.8 0.9 1.3 9.3 0.1 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.13 ESS68533.1 - 0.048 13.6 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.19 ESS68533.1 - 0.15 10.9 19.1 0.21 10.4 1.5 3.6 2 2 2 4 4 4 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 ESS68533.1 - 1.5 7.6 4.3 4.3 6.1 0.4 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein Cyclin_N PF00134.18 ESS68534.1 - 5e-38 129.5 0.6 1e-37 128.5 0.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESS68534.1 - 6.8e-33 113.1 0.8 1.2e-32 112.3 0.1 1.8 2 1 0 2 2 2 1 Cyclin, C-terminal domain zf-B_box PF00643.19 ESS68536.1 - 1.2e-07 31.5 1.2 2.7e-07 30.3 0.8 1.7 1 0 0 1 1 1 1 B-box zinc finger zf-RING_5 PF14634.1 ESS68536.1 - 1.2 8.9 4.9 3.2 7.5 3.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Lipase_3 PF01764.20 ESS68537.1 - 6.3e-16 58.2 0.0 9.7e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Voltage_CLC PF00654.15 ESS68538.1 - 1.7e-81 273.9 27.0 2.9e-80 269.9 17.4 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.23 ESS68538.1 - 1.1e-11 44.3 0.1 0.00025 20.7 0.0 2.8 2 0 0 2 2 2 2 CBS domain TruD PF01142.13 ESS68539.1 - 4.2e-45 154.0 0.0 1.9e-35 122.2 0.0 3.2 2 1 1 3 3 3 3 tRNA pseudouridine synthase D (TruD) DUF1488 PF07369.6 ESS68539.1 - 0.11 12.3 0.0 0.69 9.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) zf-MYND PF01753.13 ESS68540.1 - 1.7e-05 24.5 8.4 5.2e-05 23.0 5.8 1.9 1 0 0 1 1 1 1 MYND finger DUF3447 PF11929.3 ESS68540.1 - 0.012 15.4 0.8 1.4 8.8 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) zf-Mss51 PF13824.1 ESS68540.1 - 0.11 12.4 4.3 0.28 11.0 2.9 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Abhydrolase_1 PF00561.15 ESS68541.1 - 0.01 15.4 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Dopey_N PF04118.9 ESS68542.1 - 8.9e-30 103.5 0.0 1.6e-29 102.7 0.0 1.4 1 1 0 1 1 1 1 Dopey, N-terminal MMS19_C PF12460.3 ESS68542.1 - 0.11 11.2 1.5 0.11 11.1 0.1 1.6 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal Cytochrom_B558a PF05038.8 ESS68544.1 - 0.13 11.8 0.4 0.43 10.1 0.2 1.9 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit UPF0564 PF10595.4 ESS68545.1 - 2.4e-12 46.4 32.1 5.5e-10 38.6 5.3 3.7 4 0 0 4 4 4 3 Uncharacterised protein family UPF0564 Mrr_N PF14338.1 ESS68545.1 - 0.022 14.8 0.2 0.1 12.7 0.1 2.2 1 0 0 1 1 1 0 Mrr N-terminal domain LRR_6 PF13516.1 ESS68546.1 - 0.00038 20.2 0.4 0.12 12.4 0.2 3.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_8 PF13855.1 ESS68546.1 - 1.2 8.9 5.8 0.13 12.0 0.3 2.1 3 0 0 3 3 3 0 Leucine rich repeat Nodulin-like PF06813.8 ESS68547.1 - 6.2e-12 45.2 16.5 6.2e-12 45.2 11.5 2.8 2 1 0 2 2 2 1 Nodulin-like DUF1129 PF06570.6 ESS68547.1 - 3.5 6.8 6.6 4.9 6.3 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Papilloma_E5A PF05776.7 ESS68548.1 - 0.12 12.4 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 Papillomavirus E5A protein zf-C2HC_2 PF13913.1 ESS68549.1 - 9.2e-23 79.3 14.4 4e-10 39.1 0.3 3.5 3 0 0 3 3 3 3 zinc-finger of a C2HC-type Sgf11 PF08209.6 ESS68549.1 - 6e-06 25.4 6.9 0.017 14.3 0.2 2.7 2 0 0 2 2 2 2 Sgf11 (transcriptional regulation protein) zf-ribbon_3 PF13248.1 ESS68549.1 - 2.1e-05 23.5 13.7 5e-05 22.3 0.9 3.8 4 0 0 4 4 4 2 zinc-ribbon domain DZR PF12773.2 ESS68549.1 - 6.8e-05 22.6 1.3 6.8e-05 22.6 0.9 4.5 5 0 0 5 5 5 1 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESS68549.1 - 0.00019 20.7 3.1 0.00019 20.7 2.2 3.7 4 0 0 4 4 4 1 zinc-ribbon domain zf-H2C2_2 PF13465.1 ESS68549.1 - 0.093 13.0 5.8 1.7 9.1 0.2 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESS68549.1 - 0.1 13.0 0.4 0.1 13.0 0.3 3.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type DUF164 PF02591.10 ESS68549.1 - 0.73 9.6 6.0 5.6 6.8 0.0 3.3 4 0 0 4 4 4 0 Putative zinc ribbon domain zf-NADH-PPase PF09297.6 ESS68549.1 - 0.78 9.3 6.4 0.62 9.6 0.2 3.5 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain GFA PF04828.9 ESS68549.1 - 4.7 7.2 8.8 33 4.5 1.9 3.9 3 1 0 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme RNase_PH PF01138.16 ESS68550.1 - 2.8e-07 30.8 0.0 4.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESS68550.1 - 0.00076 19.3 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 UPF0506 PF11703.3 ESS68550.1 - 0.047 13.6 0.7 8.4 6.4 0.0 2.3 2 0 0 2 2 2 0 UPF0506 RRM_1 PF00076.17 ESS68551.1 - 1.4e-14 53.4 0.0 4.2e-12 45.5 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68551.1 - 4.3e-13 49.0 0.0 2.9e-11 43.1 0.0 2.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS68551.1 - 2.2e-07 30.6 0.0 6.4e-06 25.9 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_11 PF13414.1 ESS68552.1 - 0.00028 20.4 2.3 0.19 11.4 0.1 3.4 2 1 0 3 3 3 1 TPR repeat TPR_12 PF13424.1 ESS68552.1 - 0.00093 19.0 11.2 0.0077 16.1 0.5 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68552.1 - 0.0039 17.8 6.0 0.0041 17.7 1.2 3.0 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS68552.1 - 0.0052 16.8 0.9 11 6.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS68552.1 - 0.0056 16.7 0.4 0.027 14.5 0.0 2.3 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESS68552.1 - 0.041 13.6 0.5 0.91 9.4 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68552.1 - 0.044 14.1 3.0 0.046 14.0 0.7 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68552.1 - 0.39 11.2 3.2 12 6.5 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68552.1 - 0.77 10.5 10.8 1.4 9.8 2.0 4.1 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68552.1 - 1.3 9.1 7.3 10 6.3 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESS68552.1 - 1.7 8.7 5.7 2.6 8.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DEAD PF00270.24 ESS68553.1 - 1.5e-15 57.1 0.0 3.9e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS68553.1 - 1.5e-06 28.2 0.0 5.2e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESS68553.1 - 0.00011 22.3 0.0 0.069 13.2 0.0 3.2 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.1 ESS68553.1 - 0.0056 16.1 0.0 0.73 9.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESS68553.1 - 0.0069 15.8 0.0 0.018 14.4 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 ESS68553.1 - 0.013 15.1 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain SecA_DEAD PF07517.9 ESS68553.1 - 0.044 13.0 0.0 3.3 6.9 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain PhoH PF02562.11 ESS68553.1 - 0.078 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.1 ESS68553.1 - 0.094 12.2 0.0 0.27 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain Nuc_sug_transp PF04142.10 ESS68554.1 - 1.3e-46 158.7 8.5 2.5e-46 157.7 5.9 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter EmrE PF13536.1 ESS68554.1 - 0.00014 22.0 2.5 0.00014 22.0 1.7 3.6 3 1 1 4 4 4 1 Multidrug resistance efflux transporter TPT PF03151.11 ESS68554.1 - 0.0038 16.8 1.7 0.0038 16.8 1.2 3.5 3 1 0 3 3 3 1 Triose-phosphate Transporter family NDUF_B12 PF08122.7 ESS68554.1 - 0.046 13.4 2.0 14 5.4 0.0 4.6 5 0 0 5 5 5 0 NADH-ubiquinone oxidoreductase B12 subunit family UAA PF08449.6 ESS68554.1 - 0.1 11.5 18.1 0.0033 16.3 7.4 1.9 2 0 0 2 2 2 0 UAA transporter family SelP_N PF04592.9 ESS68555.1 - 0.6 9.4 16.2 0.72 9.1 11.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region YfhO PF09586.5 ESS68555.1 - 4.3 5.2 7.1 4.6 5.1 4.9 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO zf-CCCH PF00642.19 ESS68556.1 - 0.013 15.1 13.0 0.1 12.2 1.3 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RabGAP-TBC PF00566.13 ESS68557.1 - 4.2e-27 95.0 0.5 8.5e-27 94.0 0.3 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1467 PF07330.7 ESS68557.1 - 1.9 8.3 5.0 37 4.2 1.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1467) ClpS PF02617.12 ESS68559.1 - 0.077 12.7 0.5 0.17 11.6 0.4 1.7 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS zf-C4pol PF14260.1 ESS68559.1 - 0.099 12.6 0.3 0.24 11.4 0.2 1.8 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Gtr1_RagA PF04670.7 ESS68559.1 - 0.12 11.5 0.5 0.15 11.1 0.3 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ECH_C PF13766.1 ESS68562.1 - 5.1e-31 107.2 0.0 7.3e-31 106.7 0.0 1.2 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 ESS68562.1 - 4.5e-19 68.5 0.0 9.5e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family zinc_ribbon_2 PF13240.1 ESS68563.1 - 7.9e-05 22.0 5.7 0.00023 20.5 3.9 1.9 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESS68563.1 - 0.00017 20.7 3.8 0.00044 19.3 2.6 1.7 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 ESS68563.1 - 0.062 13.1 0.4 0.062 13.1 0.3 2.0 2 0 0 2 2 2 0 Double zinc ribbon TMEM18 PF14770.1 ESS68565.1 - 2.5e-36 123.8 4.1 3e-36 123.6 2.8 1.0 1 0 0 1 1 1 1 Transmembrane protein 18 DUF3733 PF12534.3 ESS68565.1 - 0.063 12.5 0.5 0.14 11.4 0.4 1.6 1 0 0 1 1 1 0 Leucine-rich repeat containing protein 8 UPF0542 PF15086.1 ESS68565.1 - 0.19 11.4 0.8 18 5.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF1434 PF07254.7 ESS68565.1 - 0.27 11.0 2.0 0.3 10.8 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1434) DUF788 PF05620.6 ESS68565.1 - 0.72 9.6 3.3 1.1 9.0 2.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF788) DUF4282 PF14110.1 ESS68565.1 - 4 7.7 12.4 6.3 7.0 3.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) DUF4131 PF13567.1 ESS68565.1 - 9.7 5.5 9.8 2.8 7.3 3.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Enolase_N PF03952.11 ESS68566.1 - 1.8e-17 63.5 0.0 3.2e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain Enolase_C PF00113.17 ESS68566.1 - 0.00027 20.0 0.0 0.002 17.1 0.0 2.2 1 1 0 1 1 1 1 Enolase, C-terminal TIM barrel domain F420_ligase PF01996.11 ESS68566.1 - 0.042 12.8 0.0 0.24 10.4 0.0 2.0 2 0 0 2 2 2 0 F420-0:Gamma-glutamyl ligase WD40 PF00400.27 ESS68567.1 - 0.0002 21.0 0.8 0.79 9.7 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Proteasome_A_N PF10584.4 ESS68567.1 - 0.004 16.4 0.6 8.1 5.8 0.0 3.5 3 0 0 3 3 3 3 Proteasome subunit A N-terminal signature HEAT_EZ PF13513.1 ESS68568.1 - 4.5e-10 39.7 15.4 0.00028 21.2 0.0 7.8 7 2 2 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.1 ESS68568.1 - 1.7e-07 31.4 11.5 0.086 13.1 0.0 6.2 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.17 ESS68568.1 - 4.6e-05 23.1 14.8 0.49 10.5 0.0 7.3 8 0 0 8 8 8 2 HEAT repeat IBN_N PF03810.14 ESS68568.1 - 0.00035 20.4 0.1 0.001 18.9 0.1 1.8 1 0 0 1 1 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.2 ESS68568.1 - 0.014 15.8 0.0 0.63 10.4 0.0 3.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Arm PF00514.18 ESS68568.1 - 0.36 10.7 5.5 15 5.5 0.0 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Arm PF00514.18 ESS68569.1 - 0.02 14.7 0.2 93 3.0 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CENP-B_dimeris PF09026.5 ESS68569.1 - 4.9 7.4 8.8 6.3 7.1 0.6 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain HOOK PF05622.7 ESS68570.1 - 0.0096 13.7 2.8 0.012 13.4 1.9 1.0 1 0 0 1 1 1 1 HOOK protein APG6 PF04111.7 ESS68570.1 - 0.31 10.0 3.0 0.41 9.6 2.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 SHQ1 PF04925.10 ESS68572.1 - 2.4e-54 183.6 0.0 4e-54 182.9 0.0 1.3 1 0 0 1 1 1 1 SHQ1 protein CKS PF01111.14 ESS68574.1 - 1.8e-36 123.8 1.9 2.2e-36 123.4 1.3 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DUF1965 PF09248.5 ESS68574.1 - 0.047 13.5 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) Robl_LC7 PF03259.12 ESS68575.1 - 7.4e-13 47.8 0.1 9.7e-13 47.5 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain Toxin_36 PF10550.4 ESS68575.1 - 0.017 16.1 0.5 0.04 15.0 0.4 1.6 1 0 0 1 1 1 0 Conantokin-G mollusc-toxin DUF2054 PF10218.4 ESS68576.1 - 0.03 14.1 0.4 0.044 13.6 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2054) DUF2614 PF11023.3 ESS68576.1 - 0.16 11.7 0.3 0.26 11.1 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2614) TPR_11 PF13414.1 ESS68578.1 - 3.9e-10 39.2 2.6 3.5e-06 26.5 0.7 2.4 1 1 1 2 2 2 2 TPR repeat TPR_12 PF13424.1 ESS68578.1 - 1.4e-06 28.1 1.6 0.00033 20.5 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS68578.1 - 1.3e-05 24.5 0.1 1.4 8.6 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68578.1 - 3.1e-05 23.5 0.3 0.4 10.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF3856 PF12968.2 ESS68578.1 - 0.00037 20.3 0.3 0.00059 19.6 0.2 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF3856) TPR_10 PF13374.1 ESS68578.1 - 0.00062 19.6 3.4 0.33 10.9 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS68578.1 - 0.0013 18.5 6.1 0.66 9.8 0.1 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS68578.1 - 0.028 14.1 0.0 1.9 8.4 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68578.1 - 0.1 12.4 1.1 0.53 10.2 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68578.1 - 0.19 12.4 8.4 0.5 11.1 0.4 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68578.1 - 2.2 8.9 7.4 45 4.8 0.1 3.8 4 1 1 5 5 4 0 Tetratricopeptide repeat Cornichon PF03311.9 ESS68579.1 - 9.4e-05 22.5 7.1 9.4e-05 22.5 4.9 1.6 1 1 1 2 2 2 1 Cornichon protein DUF3980 PF13140.1 ESS68579.1 - 0.27 11.5 12.5 4.2 7.7 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3980) Tic20 PF09685.5 ESS68579.1 - 4 7.4 22.1 0.069 13.1 1.9 2.4 2 1 0 2 2 2 0 Tic20-like protein DUF4233 PF14017.1 ESS68580.1 - 0.56 10.1 4.6 0.18 11.7 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4233) TYW3 PF02676.9 ESS68581.1 - 8.5e-31 106.6 0.0 1.1e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 Arf PF00025.16 ESS68582.1 - 1.1e-06 27.9 0.1 7e-06 25.3 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESS68582.1 - 3.4e-05 22.7 0.0 0.021 13.5 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 ESS68582.1 - 4.4e-05 23.9 0.0 7.2e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESS68582.1 - 6.6e-05 22.8 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESS68582.1 - 0.00033 19.8 0.0 0.00071 18.7 0.0 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_17 PF13207.1 ESS68582.1 - 0.0013 19.5 0.2 0.003 18.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain CobU PF02283.11 ESS68582.1 - 0.0047 16.3 0.0 0.008 15.5 0.0 1.4 1 0 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase ABC_tran PF00005.22 ESS68582.1 - 0.0074 16.5 0.1 0.031 14.5 0.0 1.8 2 0 0 2 2 2 1 ABC transporter Ras PF00071.17 ESS68582.1 - 0.016 14.6 0.0 0.044 13.1 0.0 1.9 1 1 0 1 1 1 0 Ras family AAA_18 PF13238.1 ESS68582.1 - 0.022 15.0 0.1 0.092 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 ESS68582.1 - 0.024 14.4 0.0 0.29 10.9 0.0 2.0 1 1 0 2 2 2 0 Dynamin family AAA_16 PF13191.1 ESS68582.1 - 0.026 14.5 0.0 0.46 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.2 ESS68582.1 - 0.077 12.4 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 ESS68582.1 - 0.079 12.4 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rab5ip PF07019.7 ESS68583.1 - 1.8e-19 69.6 3.9 2.1e-19 69.3 2.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Aph-1 PF06105.7 ESS68583.1 - 0.026 13.7 0.6 0.04 13.1 0.4 1.2 1 0 0 1 1 1 0 Aph-1 protein DUF4257 PF14074.1 ESS68583.1 - 0.51 10.0 2.9 1.7 8.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4257) BTP PF05232.7 ESS68583.1 - 0.73 9.6 5.7 7.5 6.3 0.3 2.2 2 0 0 2 2 2 0 Bacterial Transmembrane Pair family L51_S25_CI-B8 PF05047.11 ESS68584.1 - 0.00052 19.7 0.0 0.00081 19.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain UT PF03253.9 ESS68586.1 - 0.0079 15.1 0.5 0.0093 14.8 0.4 1.0 1 0 0 1 1 1 1 Urea transporter CAML PF14963.1 ESS68586.1 - 0.1 11.9 0.1 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand U79_P34 PF03064.11 ESS68610.1 - 0.035 13.6 1.6 0.24 10.8 1.3 1.9 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Atrophin-1 PF03154.10 ESS68610.1 - 0.15 10.1 3.1 0.21 9.6 2.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family Dynamin_N PF00350.18 ESS68611.1 - 3.8e-17 62.6 0.0 7.7e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESS68611.1 - 6.3e-10 39.0 0.0 1.7e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESS68611.1 - 9.7e-05 22.8 0.0 0.074 13.5 0.0 2.7 3 0 0 3 3 3 2 Miro-like protein GTP_EFTU PF00009.22 ESS68611.1 - 0.00011 21.7 0.0 0.12 11.8 0.0 2.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESS68611.1 - 0.00018 20.7 0.0 0.015 14.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ESS68611.1 - 0.0025 17.1 0.0 0.58 9.4 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B AIG1 PF04548.11 ESS68611.1 - 0.0091 15.1 0.2 3.3 6.7 0.0 2.6 3 0 0 3 3 3 2 AIG1 family ABC_tran PF00005.22 ESS68611.1 - 0.029 14.6 0.0 0.079 13.2 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Arf PF00025.16 ESS68611.1 - 0.089 12.0 0.0 0.45 9.7 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family Pkinase PF00069.20 ESS68612.1 - 3.2e-55 187.0 0.0 5.3e-49 166.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68612.1 - 7.1e-21 74.4 0.0 6.8e-17 61.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS68612.1 - 0.00018 21.2 0.9 0.00045 20.0 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS68612.1 - 0.0003 19.8 0.0 0.0013 17.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESS68612.1 - 0.044 12.8 0.0 0.086 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESS68612.1 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase P5CR_dimer PF14748.1 ESS68613.1 - 2.3e-41 140.1 2.4 4.1e-41 139.3 1.6 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 ESS68613.1 - 5e-18 65.3 0.1 1.2e-17 64.0 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 ESS68613.1 - 1.5e-06 28.1 0.1 2.8e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 ESS68613.1 - 4.5e-05 23.5 0.0 8.2e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 ESS68613.1 - 0.00061 19.5 0.7 0.0023 17.6 0.5 2.0 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GFO_IDH_MocA PF01408.17 ESS68613.1 - 0.0039 17.7 0.0 0.011 16.2 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold PDH PF02153.12 ESS68613.1 - 0.18 10.6 2.2 0.31 9.8 1.4 1.7 1 1 0 1 1 1 0 Prephenate dehydrogenase Med26 PF08711.6 ESS68614.1 - 4.7e-07 29.2 2.5 6.7e-05 22.3 0.0 2.7 2 0 0 2 2 2 2 TFIIS helical bundle-like domain MIP-T3 PF10243.4 ESS68614.1 - 0.048 12.1 21.6 0.07 11.5 14.9 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 BTV_NS2 PF04514.7 ESS68614.1 - 0.67 8.7 16.9 1.1 8.0 11.7 1.4 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 AAA_19 PF13245.1 ESS68615.1 - 1e-05 25.2 0.0 5.7e-05 22.7 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain KaiC PF06745.8 ESS68615.1 - 0.0047 16.0 0.0 0.0077 15.3 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_33 PF13671.1 ESS68615.1 - 0.0061 16.4 1.8 0.0069 16.2 0.2 1.9 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESS68615.1 - 0.009 15.4 0.0 0.024 14.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.10 ESS68615.1 - 0.015 14.2 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_17 PF13207.1 ESS68615.1 - 0.018 15.8 0.0 0.043 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESS68615.1 - 0.033 14.3 0.0 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS68615.1 - 0.045 13.8 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ESS68615.1 - 0.1 11.8 0.6 0.15 11.2 0.0 1.5 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.7 ESS68615.1 - 0.11 12.0 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 ESS68615.1 - 0.14 11.0 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 ESS68615.1 - 0.16 11.4 0.1 0.93 8.8 0.2 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RabGAP-TBC PF00566.13 ESS68616.1 - 3.2e-40 137.8 2.5 4.6e-40 137.3 1.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.3 ESS68616.1 - 0.00017 20.9 0.0 0.00037 19.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3548) FHA PF00498.21 ESS68617.1 - 8.1e-19 67.5 0.0 1.4e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 FHA domain Rotamase PF00639.16 ESS68617.1 - 2.9e-17 63.1 0.0 6.6e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 ESS68617.1 - 3.4e-09 36.9 0.0 8.3e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 ESS68617.1 - 0.0025 18.4 0.1 0.0097 16.5 0.0 2.0 3 0 0 3 3 3 1 PPIC-type PPIASE domain PPR PF01535.15 ESS68618.1 - 6e-05 22.7 0.2 11 6.2 0.3 6.0 8 0 0 8 8 8 1 PPR repeat PPR_3 PF13812.1 ESS68618.1 - 0.0057 16.8 7.6 2.3 8.7 0.1 5.9 5 0 0 5 5 5 1 Pentatricopeptide repeat domain Apc3 PF12895.2 ESS68618.1 - 0.0087 16.1 0.0 0.34 11.0 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS68618.1 - 0.92 10.3 17.1 74 4.3 0.2 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat Kinesin PF00225.18 ESS68619.1 - 1.9e-87 293.1 0.0 1.9e-87 293.1 0.0 2.0 3 0 0 3 3 3 1 Kinesin motor domain Seryl_tRNA_N PF02403.17 ESS68619.1 - 0.0075 16.2 6.3 0.0075 16.2 4.4 4.6 3 1 1 5 5 5 2 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.4 ESS68619.1 - 0.93 9.6 12.7 1.5 8.9 1.2 3.6 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med9 PF07544.8 ESS68619.1 - 2.3 7.9 15.1 0.52 10.0 0.6 4.6 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF2205 PF10224.4 ESS68619.1 - 3.1 7.4 17.9 0.099 12.2 0.5 4.0 4 1 0 4 4 4 0 Predicted coiled-coil protein (DUF2205) AAA PF00004.24 ESS68620.1 - 2.2e-42 144.3 0.0 4.6e-42 143.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS68620.1 - 4.8e-07 29.9 0.1 0.00017 21.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESS68620.1 - 1.7e-06 27.8 0.1 5.6e-05 22.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS68620.1 - 2.4e-05 24.4 0.0 3.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 ESS68620.1 - 4.8e-05 23.3 0.0 9.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 ESS68620.1 - 5.2e-05 24.0 0.1 0.00016 22.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESS68620.1 - 0.00019 20.5 0.0 0.00049 19.2 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ESS68620.1 - 0.00058 18.8 0.0 0.0012 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESS68620.1 - 0.00067 19.3 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 ESS68620.1 - 0.0012 18.6 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESS68620.1 - 0.0013 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESS68620.1 - 0.0017 17.5 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Arch_ATPase PF01637.13 ESS68620.1 - 0.0018 18.0 0.0 0.25 11.0 0.0 2.5 1 1 1 2 2 2 1 Archaeal ATPase IstB_IS21 PF01695.12 ESS68620.1 - 0.0028 17.1 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 ESS68620.1 - 0.0028 17.5 0.0 0.0053 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESS68620.1 - 0.0046 17.1 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 ESS68620.1 - 0.0073 16.6 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESS68620.1 - 0.0076 15.4 0.0 0.019 14.1 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 ESS68620.1 - 0.0086 15.6 0.1 0.017 14.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESS68620.1 - 0.0098 14.6 0.0 0.016 13.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_3 PF07726.6 ESS68620.1 - 0.01 15.4 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESS68620.1 - 0.021 14.5 0.1 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 NTPase AAA_25 PF13481.1 ESS68620.1 - 0.022 14.1 1.4 0.14 11.5 0.1 2.2 1 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 ESS68620.1 - 0.039 13.4 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Histone PF00125.19 ESS68620.1 - 0.062 13.4 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 PhoH PF02562.11 ESS68620.1 - 0.065 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.12 ESS68620.1 - 0.067 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 ESS68620.1 - 0.096 11.5 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.1 ESS68620.1 - 0.12 11.9 0.0 0.27 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 ESS68620.1 - 0.12 12.4 0.0 0.36 10.8 0.0 1.9 2 1 0 2 2 1 0 Sigma-54 interaction domain UPF0066 PF01980.11 ESS68621.1 - 8.6e-30 103.1 0.0 1.6e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family UPF0066 PWWP PF00855.12 ESS68621.1 - 7.3e-05 22.8 0.1 0.00017 21.7 0.0 1.7 1 1 0 1 1 1 1 PWWP domain Acetyltransf_3 PF13302.1 ESS68622.1 - 3.8e-21 75.7 0.5 5.1e-20 72.0 0.3 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESS68622.1 - 3.6e-06 26.9 0.0 6.5e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 ESS68622.1 - 4.1e-06 26.7 0.7 0.00014 21.7 0.0 2.5 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESS68622.1 - 1.6e-05 24.8 0.0 3.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESS68622.1 - 0.031 14.4 0.0 0.35 11.0 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain UQ_con PF00179.21 ESS68623.1 - 1.4e-43 147.7 0.0 1.9e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESS68623.1 - 0.0006 19.5 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.6 ESS68623.1 - 0.078 12.4 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 GAGA_bind PF06217.7 ESS68624.1 - 1.8e-05 24.8 3.2 2e-05 24.7 2.2 1.0 1 0 0 1 1 1 1 GAGA binding protein-like family DUF4337 PF14235.1 ESS68624.1 - 0.00053 19.8 2.8 0.00065 19.5 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4337) DUF2207 PF09972.4 ESS68624.1 - 0.0045 15.6 0.1 0.0055 15.3 0.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Folate_carrier PF01770.13 ESS68624.1 - 0.04 12.4 0.8 0.049 12.1 0.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF913 PF06025.7 ESS68624.1 - 0.081 11.6 0.8 0.097 11.4 0.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AAA_11 PF13086.1 ESS68624.1 - 0.18 11.3 3.9 0.21 11.1 2.7 1.1 1 0 0 1 1 1 0 AAA domain DUF3513 PF12026.3 ESS68624.1 - 0.18 11.2 6.8 0.23 10.9 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) CDC45 PF02724.9 ESS68624.1 - 0.19 9.6 6.6 0.23 9.4 4.6 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.7 ESS68624.1 - 0.28 11.0 11.6 0.37 10.6 8.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 60KD_IMP PF02096.15 ESS68624.1 - 0.47 10.0 1.9 0.72 9.4 1.3 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein HNOBA PF07701.9 ESS68624.1 - 0.56 9.3 6.7 1 8.5 4.6 1.5 1 1 0 1 1 1 0 Heme NO binding associated DUF4448 PF14610.1 ESS68624.1 - 1.2 8.5 4.9 4.7 6.6 3.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) OmpH PF03938.9 ESS68624.1 - 1.7 8.5 13.2 2.2 8.1 9.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MIP-T3 PF10243.4 ESS68624.1 - 2.1 6.7 28.6 2.7 6.3 19.9 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3899 PF13038.1 ESS68624.1 - 2.3 8.4 9.7 92 3.3 6.7 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) DUF3807 PF12720.2 ESS68624.1 - 3.4 7.8 15.7 4.3 7.4 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) U79_P34 PF03064.11 ESS68624.1 - 6.4 6.2 18.8 8.7 5.7 13.0 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF912 PF06024.7 ESS68624.1 - 6.6 6.8 7.1 36 4.4 4.9 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) NARP1 PF12569.3 ESS68624.1 - 8.2 5.0 22.0 10 4.7 15.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Vfa1 PF08432.5 ESS68624.1 - 8.6 6.3 22.4 12 5.8 15.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AAA PF00004.24 ESS68625.1 - 4.5e-39 133.6 1.3 8.5e-39 132.7 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS68625.1 - 6.2e-06 25.4 0.0 0.002 17.2 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESS68625.1 - 7.1e-06 25.7 0.0 0.00011 21.9 0.0 2.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS68625.1 - 2.5e-05 24.3 1.9 0.014 15.3 0.0 2.9 2 1 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.9 ESS68625.1 - 0.00016 21.6 0.5 0.00088 19.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 ESS68625.1 - 0.0014 17.6 0.0 0.0036 16.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Bacillus_HBL PF05791.6 ESS68625.1 - 0.0017 17.7 3.8 0.0051 16.2 2.6 1.7 2 0 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) AAA_22 PF13401.1 ESS68625.1 - 0.0019 18.3 2.4 0.055 13.6 0.1 2.9 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.17 ESS68625.1 - 0.0076 16.4 0.0 0.22 11.7 0.0 2.5 3 0 0 3 3 2 1 RNA helicase Mg_chelatase PF01078.16 ESS68625.1 - 0.0078 15.3 0.0 0.018 14.2 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESS68625.1 - 0.0079 15.9 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 ESS68625.1 - 0.008 16.0 2.6 0.028 14.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 ESS68625.1 - 0.015 14.7 0.1 0.047 13.1 0.1 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 ESS68625.1 - 0.015 14.4 1.5 0.15 11.1 0.0 2.6 3 0 0 3 3 3 0 KaiC NACHT PF05729.7 ESS68625.1 - 0.017 14.7 0.1 0.63 9.6 0.0 2.4 1 1 1 2 2 2 0 NACHT domain CPT PF07931.7 ESS68625.1 - 0.018 14.6 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.7 ESS68625.1 - 0.019 14.0 1.1 0.031 13.3 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.1 ESS68625.1 - 0.031 13.6 4.5 0.027 13.8 0.7 2.5 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.6 ESS68625.1 - 0.037 13.6 0.0 0.1 12.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 ESS68625.1 - 0.04 13.1 0.0 0.23 10.6 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Vir_act_alpha_C PF10400.4 ESS68625.1 - 0.047 14.0 1.7 0.12 12.7 1.2 1.6 1 0 0 1 1 1 0 Virulence activator alpha C-term AAA_28 PF13521.1 ESS68625.1 - 0.064 13.2 0.8 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 ESS68625.1 - 0.074 12.6 1.2 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Atg14 PF10186.4 ESS68625.1 - 0.097 11.5 5.2 0.14 11.0 3.6 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_17 PF13207.1 ESS68625.1 - 0.098 13.4 4.7 0.098 13.4 0.1 2.7 2 2 0 2 2 2 0 AAA domain APG6 PF04111.7 ESS68625.1 - 0.27 10.2 7.6 0.42 9.5 5.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_18 PF13238.1 ESS68625.1 - 0.83 9.9 5.6 0.91 9.8 0.1 2.9 2 2 0 2 2 2 0 AAA domain TBPIP PF07106.8 ESS68625.1 - 1.2 8.6 11.0 2.4 7.6 7.6 1.5 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 ESS68625.1 - 1.6 9.1 7.7 2.8 8.3 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF496 PF04363.7 ESS68625.1 - 2.2 8.1 11.1 0.83 9.5 2.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF496) Na_K-ATPase PF00287.13 ESS68626.1 - 0.11 11.2 2.2 0.079 11.7 0.4 1.5 2 0 0 2 2 2 0 Sodium / potassium ATPase beta chain HeH PF12949.2 ESS68628.1 - 0.091 12.3 0.0 7.3 6.2 0.0 2.5 2 0 0 2 2 2 0 HeH/LEM domain Enkurin PF13864.1 ESS68630.1 - 0.11 12.6 12.9 4 7.7 3.3 2.4 1 1 1 2 2 2 0 Calmodulin-binding APG6 PF04111.7 ESS68630.1 - 0.31 10.0 11.1 0.43 9.5 7.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 YbaB_DNA_bd PF02575.11 ESS68631.1 - 2.3e-05 24.1 0.0 4.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family Miro PF08477.8 ESS68632.1 - 0.0099 16.3 0.0 2 8.9 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein Myb_DNA-binding PF00249.26 ESS68632.1 - 0.013 15.5 1.0 0.48 10.5 0.1 2.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain MMR_HSR1 PF01926.18 ESS68632.1 - 0.035 14.0 0.0 0.3 11.0 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 ESS68632.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.18 ESS68633.1 - 3.3e-15 56.0 0.0 8.8e-15 54.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESS68633.1 - 1.5e-07 31.3 0.0 4.6e-06 26.5 0.1 2.6 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 ESS68633.1 - 1.2e-06 28.1 0.0 1.8e-05 24.2 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESS68633.1 - 3.5e-05 24.2 0.1 0.00046 20.6 0.0 2.8 2 1 0 2 2 2 1 Miro-like protein Septin PF00735.13 ESS68633.1 - 0.0021 17.1 0.0 0.0068 15.4 0.0 1.8 2 0 0 2 2 2 1 Septin AIG1 PF04548.11 ESS68633.1 - 0.0036 16.4 0.2 0.0073 15.4 0.1 1.6 1 1 0 1 1 1 1 AIG1 family DUF258 PF03193.11 ESS68633.1 - 0.0052 15.9 0.0 0.012 14.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Guanylate_kin PF00625.16 ESS68633.1 - 0.02 14.3 0.0 0.049 13.0 0.0 1.6 1 0 0 1 1 1 0 Guanylate kinase ABC_tran PF00005.22 ESS68633.1 - 0.034 14.4 0.0 0.15 12.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Gtr1_RagA PF04670.7 ESS68633.1 - 0.14 11.3 0.0 0.63 9.1 0.0 2.0 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2058 PF09831.4 ESS68634.1 - 0.0018 18.1 2.9 0.0018 18.1 2.0 2.2 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2058) DUF3759 PF12585.3 ESS68634.1 - 0.031 14.1 1.5 0.11 12.4 1.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3759) DivIVA PF05103.8 ESS68634.1 - 1.2 9.2 10.8 0.57 10.2 2.5 2.6 2 0 0 2 2 2 0 DivIVA protein ABC_tran_2 PF12848.2 ESS68634.1 - 2.7 7.8 12.7 1.6 8.6 1.8 2.5 2 0 0 2 2 2 0 ABC transporter zf-CCCH PF00642.19 ESS68635.1 - 0.068 12.8 7.3 2.5 7.8 0.2 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Glyco_hydro_57 PF03065.10 ESS68635.1 - 0.23 10.3 0.0 0.32 9.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 zf-CCCH PF00642.19 ESS68636.1 - 0.038 13.6 8.7 0.65 9.7 0.5 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.19 ESS68637.1 - 4.4e-05 23.0 6.4 0.0051 16.4 1.1 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) NAD_binding_1 PF00175.16 ESS68638.1 - 1.1e-22 80.6 0.0 1.8e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESS68638.1 - 5.7e-21 74.5 0.0 8.4e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESS68638.1 - 2e-06 27.7 0.0 1e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain SUI1 PF01253.17 ESS68639.1 - 8.8e-17 60.7 0.0 2.3e-16 59.3 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 PUA PF01472.15 ESS68639.1 - 0.021 14.5 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 0 PUA domain DUF843 PF05814.6 ESS68639.1 - 0.073 12.8 8.5 0.2 11.4 3.1 2.6 2 1 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) LRR_6 PF13516.1 ESS68640.1 - 3e-15 54.5 5.5 0.00043 20.0 0.0 5.3 6 0 0 6 6 6 4 Leucine Rich repeat LRR_1 PF00560.28 ESS68640.1 - 1.3e-07 30.6 0.2 5 7.5 0.0 5.6 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_4 PF12799.2 ESS68640.1 - 2.3e-07 30.2 2.9 0.041 13.5 0.1 3.9 3 2 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS68640.1 - 0.00025 20.7 7.7 0.26 11.0 0.4 4.0 2 1 0 3 3 3 2 Leucine rich repeat LRR_2 PF07723.8 ESS68640.1 - 0.02 15.3 0.3 46 4.7 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 ESS68640.1 - 0.097 12.9 7.4 20 5.9 0.0 5.2 5 0 0 5 5 5 0 Leucine rich repeat Pkinase PF00069.20 ESS68641.1 - 9.5e-60 201.9 0.0 1.1e-59 201.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68641.1 - 2.1e-33 115.5 0.0 2.7e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68641.1 - 3.9e-05 22.7 0.0 5.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS68641.1 - 0.0077 15.9 0.0 0.13 11.9 0.0 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS68641.1 - 0.046 12.7 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L22 PF00237.14 ESS68642.1 - 2.9e-14 52.8 0.0 4e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e IQ PF00612.22 ESS68644.1 - 0.0039 16.7 2.3 0.014 15.0 1.6 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif PMP1_2 PF08114.6 ESS68644.1 - 0.054 12.9 0.5 0.13 11.8 0.3 1.6 1 0 0 1 1 1 0 ATPase proteolipid family AAA PF00004.24 ESS68646.1 - 3.3e-16 59.6 0.0 2.7e-08 34.0 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS68646.1 - 0.00012 22.8 0.2 0.00044 21.0 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESS68646.1 - 0.00022 21.2 0.2 0.0012 18.8 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESS68646.1 - 0.0003 20.5 0.0 0.0015 18.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS68646.1 - 0.0013 18.9 0.0 0.0035 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS68646.1 - 0.0023 17.6 0.1 0.0057 16.3 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 ESS68646.1 - 0.0089 16.0 0.1 0.035 14.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 ESS68646.1 - 0.011 15.3 0.7 0.021 14.3 0.5 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESS68646.1 - 0.011 15.8 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.1 ESS68646.1 - 0.019 14.8 0.2 0.063 13.1 0.0 1.8 1 1 0 2 2 2 0 AAA domain AAA_21 PF13304.1 ESS68646.1 - 0.02 14.8 0.3 0.072 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 ESS68646.1 - 0.042 13.2 0.1 0.092 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESS68646.1 - 0.049 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.8 ESS68646.1 - 0.073 11.9 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 ESS68646.1 - 0.1 11.7 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 ESS68646.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain PPV_E1_C PF00519.12 ESS68646.1 - 0.13 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_18 PF13238.1 ESS68646.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 ESS68647.1 - 1.7e-57 194.5 0.0 2.4e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68647.1 - 2.6e-37 128.2 0.0 3.6e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68647.1 - 1.5e-08 34.0 0.0 2e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESS68647.1 - 0.046 12.7 0.0 0.082 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinesin PF00225.18 ESS68648.1 - 1.1e-90 303.6 0.0 1.1e-90 303.6 0.0 3.0 4 0 0 4 4 4 1 Kinesin motor domain Myosin_tail_1 PF01576.14 ESS68648.1 - 0.0011 16.7 45.8 0.0011 16.7 31.7 4.7 4 2 0 4 4 4 2 Myosin tail TMF_DNA_bd PF12329.3 ESS68648.1 - 0.0037 17.0 2.1 0.0037 17.0 1.5 9.3 7 3 0 8 8 8 1 TATA element modulatory factor 1 DNA binding TSC22 PF01166.13 ESS68648.1 - 0.012 15.6 1.8 0.012 15.6 1.3 7.8 7 1 1 8 8 8 0 TSC-22/dip/bun family NPR2 PF06218.6 ESS68649.1 - 0.00022 20.0 0.0 0.0045 15.7 0.0 2.3 2 0 0 2 2 2 2 Nitrogen permease regulator 2 WD40 PF00400.27 ESS68651.1 - 7.7e-12 44.6 0.9 0.019 14.8 0.1 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat HEAT_2 PF13646.1 ESS68651.1 - 0.012 15.8 0.1 0.041 14.1 0.0 1.9 1 0 0 1 1 1 0 HEAT repeats Nup160 PF11715.3 ESS68651.1 - 0.086 10.9 0.1 0.25 9.4 0.0 1.7 1 1 0 1 1 1 0 Nucleoporin Nup120/160 Resistin PF06954.6 ESS68651.1 - 0.097 12.9 0.1 2.8 8.2 0.0 2.7 3 0 0 3 3 3 0 Resistin HEAT_PBS PF03130.11 ESS68651.1 - 0.14 12.6 0.5 1.9 9.1 0.0 2.7 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat AflR PF08493.5 ESS68653.1 - 0.27 10.2 5.2 0.21 10.5 0.1 2.1 1 1 1 2 2 2 0 Aflatoxin regulatory protein UAA PF08449.6 ESS68654.1 - 3.3e-21 75.5 2.4 3.8e-21 75.2 1.7 1.1 1 0 0 1 1 1 1 UAA transporter family CbtB PF09489.5 ESS68654.1 - 2.5 8.0 4.9 5.5 6.9 0.8 3.0 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) DUF4282 PF14110.1 ESS68654.1 - 3.7 7.7 8.0 0.42 10.8 1.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) EmrE PF13536.1 ESS68654.1 - 9.3 6.4 12.9 0.06 13.5 2.2 2.2 2 1 1 3 3 3 0 Multidrug resistance efflux transporter UAA PF08449.6 ESS68655.1 - 2e-18 66.3 4.1 3.4e-18 65.6 2.8 1.5 1 1 0 1 1 1 1 UAA transporter family ABC2_membrane_2 PF12679.2 ESS68655.1 - 0.077 11.8 5.8 0.018 13.9 1.5 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein EamA PF00892.15 ESS68655.1 - 0.15 12.1 9.5 0.11 12.4 5.0 2.0 1 1 1 2 2 2 0 EamA-like transporter family TPT PF03151.11 ESS68655.1 - 0.72 9.4 11.3 0.29 10.7 5.0 2.0 2 0 0 2 2 2 0 Triose-phosphate Transporter family RRM_5 PF13893.1 ESS68656.1 - 5.5e-06 26.1 0.0 0.012 15.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS68656.1 - 0.00016 21.2 0.0 0.016 14.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68656.1 - 0.00047 20.0 0.0 0.54 10.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-U11-48K PF05253.7 ESS68656.1 - 0.00071 19.2 0.3 0.0015 18.2 0.2 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger PsbW PF07123.7 ESS68656.1 - 0.17 11.9 1.1 1.2 9.2 0.7 2.2 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) SR-25 PF10500.4 ESS68656.1 - 0.28 10.6 18.7 0.5 9.7 13.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1777 PF08648.7 ESS68656.1 - 0.43 10.2 24.5 0.73 9.5 17.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF566 PF04484.7 ESS68656.1 - 4.3 6.7 15.0 7.4 5.9 10.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) Hid1 PF12722.2 ESS68656.1 - 5 4.6 4.9 6.4 4.3 3.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Kelch_4 PF13418.1 ESS68657.1 - 9e-24 82.9 5.3 4.9e-09 35.8 0.0 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS68657.1 - 6.7e-22 77.0 8.3 1.8e-07 31.1 0.4 4.4 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS68657.1 - 3.1e-20 71.6 0.3 1e-07 31.7 0.1 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 ESS68657.1 - 2e-17 62.5 0.6 2e-07 30.8 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 ESS68657.1 - 7.7e-16 57.3 0.4 1.2e-06 27.9 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 ESS68657.1 - 2.6e-14 52.3 4.0 3.5e-06 26.5 0.1 4.5 3 2 0 3 3 3 3 Kelch motif DUF2380 PF09533.5 ESS68657.1 - 0.011 15.1 0.2 0.032 13.6 0.1 1.8 2 0 0 2 2 2 0 Predicted lipoprotein of unknown function (DUF2380) BTB PF00651.26 ESS68658.1 - 4.7e-11 42.6 0.2 1.2e-06 28.4 0.0 3.8 2 2 0 2 2 2 2 BTB/POZ domain Kelch_4 PF13418.1 ESS68658.1 - 0.00013 21.6 3.7 0.022 14.5 0.3 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESS68658.1 - 0.0024 17.9 1.2 0.1 12.7 0.0 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.20 ESS68658.1 - 0.0031 17.0 0.2 15 5.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESS68658.1 - 0.0098 16.0 0.7 0.45 10.7 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS68658.1 - 1.1 9.3 4.2 24 5.0 0.1 3.4 3 0 0 3 3 3 0 Kelch motif GPCR_chapero_1 PF11904.3 ESS68659.1 - 0.8 8.7 7.1 0.13 11.3 1.8 1.8 2 0 0 2 2 2 0 GPCR-chaperone MFS_1 PF07690.11 ESS68660.1 - 1.7e-27 96.0 61.8 1.2e-24 86.7 22.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESS68660.1 - 2.1e-20 72.7 23.3 3e-20 72.2 16.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.15 ESS68660.1 - 3.1e-10 38.7 15.9 2.2e-07 29.3 0.5 3.5 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.1 ESS68660.1 - 0.037 12.4 24.4 0.09 11.1 3.5 2.5 2 1 0 2 2 2 0 MFS/sugar transport protein Herpes_U47 PF05467.6 ESS68661.1 - 0.053 11.3 1.5 0.076 10.8 1.0 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 FAD_binding_4 PF01565.18 ESS68663.1 - 0.02 14.3 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain MBOAT_2 PF13813.1 ESS68663.1 - 0.048 13.7 0.1 0.091 12.8 0.1 1.4 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family CRAL_TRIO PF00650.15 ESS68664.1 - 1.4e-11 44.1 0.0 2.2e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 ESS68664.1 - 0.0018 18.1 0.0 0.011 15.6 0.0 2.1 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain zf-C3HC4_3 PF13920.1 ESS68665.1 - 7.7e-08 31.8 13.4 7.7e-08 31.8 9.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS68665.1 - 3 7.9 14.8 0.63 10.1 7.2 2.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DHC_N2 PF08393.8 ESS68666.1 - 2.4e-83 279.9 0.0 2.4e-83 279.9 0.0 2.5 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS68666.1 - 5.2e-83 278.1 0.0 3.4e-82 275.4 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 MT PF12777.2 ESS68666.1 - 2.5e-33 115.2 5.0 3.9e-33 114.6 2.5 1.9 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 ESS68666.1 - 5.7e-33 113.6 0.0 1.1e-32 112.7 0.0 1.4 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 ESS68666.1 - 1.2e-31 109.6 0.5 2e-22 79.4 0.0 3.1 3 0 0 3 3 3 2 P-loop containing dynein motor region D4 AAA_5 PF07728.9 ESS68666.1 - 5.4e-25 87.7 0.4 2.9e-07 30.3 0.0 6.9 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA PF00004.24 ESS68666.1 - 1.9e-17 63.7 0.0 0.00053 20.1 0.0 5.1 4 0 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.2 ESS68666.1 - 1.3e-15 57.2 0.0 4.1e-15 55.5 0.0 1.9 2 0 0 2 2 1 1 P-loop containing dynein motor region D3 AAA_22 PF13401.1 ESS68666.1 - 2.2e-11 44.0 10.8 0.00026 21.1 0.0 7.5 8 0 0 8 8 6 2 AAA domain IstB_IS21 PF01695.12 ESS68666.1 - 3e-08 33.2 0.1 0.0039 16.6 0.0 4.7 4 0 0 4 4 4 2 IstB-like ATP binding protein AAA_17 PF13207.1 ESS68666.1 - 3.2e-08 34.4 0.0 0.84 10.4 0.0 5.8 5 0 0 5 5 4 2 AAA domain AAA_33 PF13671.1 ESS68666.1 - 3.7e-08 33.3 0.4 0.32 10.8 0.0 6.6 6 0 0 6 6 6 1 AAA domain AAA_25 PF13481.1 ESS68666.1 - 1.2e-06 28.1 4.0 0.0087 15.4 0.0 5.1 5 0 0 5 5 5 2 AAA domain Mg_chelatase PF01078.16 ESS68666.1 - 1.4e-06 27.6 4.0 0.027 13.6 0.0 4.1 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 ESS68666.1 - 2.5e-06 27.5 28.4 0.067 13.1 0.0 9.2 9 1 1 10 10 10 2 AAA ATPase domain Sigma54_activat PF00158.21 ESS68666.1 - 4.9e-06 26.1 0.0 0.22 10.9 0.0 3.6 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_19 PF13245.1 ESS68666.1 - 5.2e-06 26.1 5.1 0.6 9.8 0.0 5.1 4 0 0 4 4 4 1 Part of AAA domain AAA_10 PF12846.2 ESS68666.1 - 2.8e-05 23.7 1.3 0.046 13.1 0.0 5.2 5 0 0 5 5 5 1 AAA-like domain AAA_14 PF13173.1 ESS68666.1 - 9e-05 22.3 0.0 1.2 8.9 0.0 4.5 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.1 ESS68666.1 - 0.00011 22.5 0.0 5.2 7.3 0.0 4.7 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.17 ESS68666.1 - 0.00034 20.7 0.0 9.5 6.4 0.0 4.5 4 0 0 4 4 4 0 RNA helicase Arch_ATPase PF01637.13 ESS68666.1 - 0.0014 18.3 1.8 0.58 9.8 0.0 4.4 5 0 0 5 5 4 1 Archaeal ATPase AAA_29 PF13555.1 ESS68666.1 - 0.0023 17.4 2.0 12 5.5 0.0 4.6 5 0 0 5 5 4 0 P-loop containing region of AAA domain MobB PF03205.9 ESS68666.1 - 0.027 14.1 0.2 23 4.6 0.0 4.0 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 ESS68666.1 - 0.046 13.2 2.2 39 3.7 0.0 4.3 4 0 0 4 4 4 0 AAA domain KaiC PF06745.8 ESS68666.1 - 0.12 11.5 4.1 8.8 5.3 0.0 4.1 4 0 0 4 4 4 0 KaiC ABC_tran PF00005.22 ESS68666.1 - 0.22 11.8 11.8 6.6 7.0 0.0 5.4 6 0 0 6 6 4 0 ABC transporter cobW PF02492.14 ESS68666.1 - 0.22 10.9 0.0 0.22 10.9 0.0 3.1 4 0 0 4 4 2 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.18 ESS68666.1 - 0.45 9.9 0.1 32 3.8 0.0 3.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP-synt_ab PF00006.20 ESS68666.1 - 0.46 9.9 0.0 4.7 6.6 0.0 2.7 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.1 ESS68666.1 - 5.3 7.3 15.2 19 5.5 0.8 5.4 5 0 0 5 5 5 0 AAA domain Dynein_heavy PF03028.10 ESS68667.1 - 2e-92 310.4 0.1 1.1e-90 304.7 0.0 2.6 1 1 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Lactamase_B_2 PF12706.2 ESS68668.1 - 3.5e-12 46.2 0.1 4.7e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESS68668.1 - 1.5e-06 28.0 0.9 3.3e-06 26.8 0.3 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Adap_comp_sub PF00928.16 ESS68669.1 - 2.6e-78 262.7 0.0 3.2e-78 262.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESS68669.1 - 0.00041 20.0 0.3 0.00061 19.5 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Cyclin_N PF00134.18 ESS68670.1 - 0.23 11.0 1.8 0.32 10.5 1.2 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain Pkinase PF00069.20 ESS68671.1 - 9.3e-07 28.2 0.0 1e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68671.1 - 0.00014 21.0 0.1 0.0002 20.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESS68672.1 - 8.6e-10 38.1 0.0 1.9e-09 37.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68672.1 - 1.8e-06 27.2 0.0 5e-06 25.7 0.0 1.4 1 1 1 2 2 2 1 Protein tyrosine kinase TSP9 PF11493.3 ESS68673.1 - 0.16 12.5 1.6 1.1 9.8 0.7 2.1 2 0 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 Pkinase PF00069.20 ESS68674.1 - 3.5e-35 121.4 0.0 4.9e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68674.1 - 5.8e-17 61.6 0.0 9e-17 60.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3700 PF12481.3 ESS68674.1 - 0.0049 16.0 0.0 0.57 9.3 0.0 2.5 3 0 0 3 3 3 2 Aluminium induced protein Kinase-like PF14531.1 ESS68674.1 - 0.051 12.5 0.0 0.078 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like WD40 PF00400.27 ESS68675.1 - 4.2e-08 32.7 2.7 1.5e-05 24.6 0.5 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF3650 PF12368.3 ESS68676.1 - 0.22 11.0 1.6 1 8.9 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3650) GTP_EFTU PF00009.22 ESS68677.1 - 2.3e-15 56.5 0.1 6e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 ESS68677.1 - 0.00049 19.9 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 ESS68677.1 - 0.023 14.7 0.6 1 9.4 0.1 2.7 2 0 0 2 2 2 0 Elongation factor Tu domain 2 WD40 PF00400.27 ESS68679.1 - 1e-28 98.1 1.9 1.4e-06 27.9 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 ESS68679.1 - 0.28 9.2 1.8 3.9 5.4 0.1 2.7 2 1 0 3 3 3 0 Nucleoporin Nup120/160 Beta_helix PF13229.1 ESS68680.1 - 1.5e-05 24.7 6.3 0.00057 19.6 4.4 2.5 1 1 0 1 1 1 1 Right handed beta helix region DUF1565 PF07602.6 ESS68680.1 - 0.071 12.2 0.3 2 7.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1565) CotH PF08757.6 ESS68681.1 - 6.2e-08 32.2 0.2 4e-07 29.5 0.4 1.9 2 0 0 2 2 2 1 CotH protein MORN PF02493.15 ESS68683.1 - 1.7e-07 30.5 3.7 0.0048 16.5 0.1 3.7 3 0 0 3 3 3 3 MORN repeat Atg8 PF02991.11 ESS68684.1 - 8.7e-28 96.3 0.0 8.5e-27 93.1 0.0 2.1 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 ESS68684.1 - 1.9e-06 27.9 0.0 3.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Bunya_G2 PF03563.8 ESS68684.1 - 6.2 5.6 9.5 8.9 5.0 6.6 1.2 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 ACT_5 PF13710.1 ESS68685.1 - 0.4 10.5 3.3 3.6 7.4 0.2 2.7 2 0 0 2 2 2 0 ACT domain FlxA PF14282.1 ESS68685.1 - 0.44 10.5 3.0 0.42 10.5 0.9 1.8 2 0 0 2 2 2 0 FlxA-like protein Streptin-Immun PF11083.3 ESS68686.1 - 0.00027 20.8 4.9 0.0028 17.5 0.1 3.4 2 1 1 3 3 3 1 Lantibiotic streptin immunity protein Mgr1 PF08602.5 ESS68686.1 - 0.12 11.3 0.3 0.2 10.6 0.1 1.7 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DUF940 PF06082.6 ESS68686.1 - 0.33 9.4 10.6 0.83 8.1 2.6 2.0 1 1 1 2 2 2 0 Bacterial putative lipoprotein (DUF940) DUF4047 PF13256.1 ESS68686.1 - 2 8.3 5.4 2.3 8.1 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4047) EF-hand_1 PF00036.27 ESS68687.1 - 1.2e-16 58.6 2.8 0.00046 19.3 0.1 5.6 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 ESS68687.1 - 6.3e-16 58.2 3.6 0.0003 20.8 0.1 5.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 ESS68687.1 - 4.4e-15 54.1 4.7 0.0024 17.6 0.1 6.5 7 0 0 7 7 7 4 EF-hand domain EF-hand_8 PF13833.1 ESS68687.1 - 9.2e-14 50.8 6.0 2.3e-06 27.0 0.0 5.1 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 ESS68687.1 - 6.7e-10 37.8 3.3 0.056 12.8 0.0 5.8 6 0 0 6 6 6 2 EF hand EF-hand_4 PF12763.2 ESS68687.1 - 0.00032 20.3 0.4 0.0079 15.9 0.0 2.8 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESS68687.1 - 0.012 15.6 0.3 0.032 14.2 0.0 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region LSM PF01423.17 ESS68688.1 - 8.7e-12 44.4 0.2 1.1e-11 44.0 0.1 1.1 1 0 0 1 1 1 1 LSM domain cNMP_binding PF00027.24 ESS68717.1 - 5e-09 35.8 0.0 1.4e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain ARD PF03079.9 ESS68720.1 - 1.8e-27 96.2 0.2 1.8e-27 96.2 0.1 2.1 2 0 0 2 2 2 1 ARD/ARD' family AraC_binding PF02311.14 ESS68720.1 - 5.7e-06 26.0 0.0 9.5e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.6 ESS68720.1 - 6e-05 22.4 0.0 0.0001 21.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain PhyH PF05721.8 ESS68720.1 - 0.14 12.1 0.3 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) YqfQ PF14181.1 ESS68720.1 - 1.8 8.5 4.5 2.7 8.0 3.2 1.3 1 0 0 1 1 1 0 YqfQ-like protein MAP7 PF05672.6 ESS68720.1 - 3.9 6.8 31.8 7.4 5.9 22.1 1.4 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family CAF-1_p150 PF11600.3 ESS68720.1 - 6.3 6.1 29.2 12 5.1 20.2 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Atrophin-1 PF03154.10 ESS68720.1 - 7.3 4.5 9.9 8.6 4.3 6.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family DDRGK PF09756.4 ESS68720.1 - 9.9 5.5 25.5 17 4.7 17.7 1.2 1 0 0 1 1 1 0 DDRGK domain WD40 PF00400.27 ESS68722.1 - 3.7e-05 23.4 11.4 0.62 10.0 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat RRM_1 PF00076.17 ESS68723.1 - 1.3e-28 98.4 0.0 2.2e-12 46.3 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68723.1 - 1.9e-25 88.6 0.0 4.5e-11 42.5 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS68723.1 - 3e-11 42.9 0.1 0.0019 17.9 0.0 3.9 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESS68723.1 - 3e-06 26.9 0.0 0.0096 15.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.6 ESS68723.1 - 2.9e-05 23.9 0.0 0.0025 17.7 0.0 2.4 2 0 0 2 2 2 1 RNA binding domain Nup35_RRM PF05172.8 ESS68723.1 - 0.00013 21.6 0.0 0.36 10.5 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 ESS68723.1 - 0.0017 18.1 0.2 2.6 7.9 0.3 2.7 2 1 0 2 2 2 2 RNA binding motif Rcd1 PF04078.8 ESS68724.1 - 1.3e-108 361.8 0.3 1.5e-108 361.6 0.2 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like V-ATPase_H_N PF03224.9 ESS68724.1 - 0.0031 16.6 0.0 0.54 9.3 0.0 2.4 1 1 0 2 2 2 2 V-ATPase subunit H PI3_PI4_kinase PF00454.22 ESS68725.1 - 4.5e-50 170.3 0.2 1.5e-49 168.6 0.1 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESS68725.1 - 2.5e-42 145.1 3.2 1.3e-41 142.8 2.2 2.1 1 1 0 1 1 1 1 FAT domain Rapamycin_bind PF08771.6 ESS68725.1 - 2.9e-34 117.1 1.0 1.3e-33 115.0 0.7 2.3 1 0 0 1 1 1 1 Rapamycin binding domain DUF3385 PF11865.3 ESS68725.1 - 2.9e-26 92.3 5.6 1.3e-25 90.2 0.0 4.3 5 1 1 6 6 6 1 Domain of unknown function (DUF3385) FATC PF02260.15 ESS68725.1 - 2.7e-10 39.4 0.3 7.6e-10 38.0 0.2 1.8 1 0 0 1 1 1 1 FATC domain HEAT PF02985.17 ESS68725.1 - 2.4e-06 27.1 4.6 2.7 8.3 0.0 7.4 7 1 1 8 8 8 2 HEAT repeat Vac14_Fab1_bd PF12755.2 ESS68725.1 - 0.00026 21.2 0.8 0.067 13.5 0.0 4.3 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region TPR_11 PF13414.1 ESS68725.1 - 0.076 12.6 6.5 0.16 11.6 0.9 3.2 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESS68725.1 - 0.25 11.3 6.4 4.3 7.4 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68725.1 - 2 9.1 6.1 1e+02 3.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.9 ESS68726.1 - 4.3e-96 322.3 0.1 6.6e-96 321.8 0.1 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 ESS68726.1 - 2.2e-77 260.4 0.0 3.3e-77 259.8 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 ESS68726.1 - 5.7e-50 165.4 16.1 1e-10 41.0 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 ESS68726.1 - 0.016 13.3 5.7 0.22 9.6 0.1 3.6 2 2 0 3 3 3 0 Nucleoporin Nup120/160 DUF1064 PF06356.6 ESS68726.1 - 0.13 12.2 0.1 15 5.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1064) 2OG-FeII_Oxy_2 PF13532.1 ESS68727.1 - 2.7e-50 170.8 0.0 3.5e-50 170.5 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-DHHC PF01529.15 ESS68728.1 - 1.8e-12 46.9 7.9 1.8e-12 46.9 5.5 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase Cullin_binding PF03556.10 ESS68729.1 - 1.7e-16 60.3 1.9 2.7e-16 59.7 1.3 1.3 1 0 0 1 1 1 1 Cullin binding DUF3303 PF11746.3 ESS68729.1 - 0.1 13.0 0.0 0.68 10.3 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3303) Pex24p PF06398.6 ESS68730.1 - 7.5e-05 21.6 1.1 0.00012 21.0 0.8 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Nuc_recep-AF1 PF11825.3 ESS68730.1 - 0.06 13.2 0.2 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Nuclear/hormone receptor activator site AF-1 Kinesin PF00225.18 ESS68731.1 - 5.6e-105 350.7 2.0 6.2e-105 350.5 0.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain HAUS5 PF14817.1 ESS68731.1 - 0.00033 19.3 10.3 0.00047 18.8 7.2 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 AAA_13 PF13166.1 ESS68731.1 - 0.0016 16.9 7.7 0.0016 16.9 5.3 1.6 2 0 0 2 2 2 1 AAA domain DUF3573 PF12097.3 ESS68731.1 - 0.099 11.2 5.1 0.24 9.9 3.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Fib_alpha PF08702.5 ESS68731.1 - 0.48 10.5 10.9 1.2 9.2 7.3 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TMEM192 PF14802.1 ESS68731.1 - 0.97 8.2 5.0 1.7 7.4 3.5 1.3 1 0 0 1 1 1 0 TMEM192 family FUSC PF04632.7 ESS68731.1 - 1.5 7.1 6.2 2.2 6.6 4.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4200 PF13863.1 ESS68731.1 - 2.5 8.0 23.7 2.7 7.9 2.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Mnd1 PF03962.10 ESS68731.1 - 2.8 7.5 15.8 2 8.0 1.9 2.4 1 1 1 2 2 2 0 Mnd1 family TMF_DNA_bd PF12329.3 ESS68731.1 - 4.5 7.1 33.2 0.082 12.7 8.1 3.3 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESS68731.1 - 4.6 6.7 14.3 10 5.6 4.6 2.7 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.7 ESS68731.1 - 5.7 7.3 16.5 6.8 7.1 0.3 3.4 1 1 2 3 3 3 0 SlyX DUF3827 PF12877.2 ESS68732.1 - 0.25 9.4 1.1 0.4 8.7 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) BRCT PF00533.21 ESS68733.1 - 2.2e-07 30.8 0.0 0.00044 20.3 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain FHA PF00498.21 ESS68733.1 - 5.4e-07 29.6 0.6 2.1e-06 27.7 0.0 2.3 3 0 0 3 3 3 1 FHA domain PTCB-BRCT PF12738.2 ESS68733.1 - 0.0095 15.7 0.0 0.023 14.5 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain Mito_fiss_reg PF05308.6 ESS68735.1 - 0.83 8.9 13.5 1.3 8.3 8.7 1.7 1 1 0 1 1 1 0 Mitochondrial fission regulator Metallophos PF00149.23 ESS68736.1 - 1.7e-36 125.5 0.3 2.1e-36 125.1 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESS68736.1 - 0.0011 18.8 0.0 0.0013 18.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF1655 PF07868.6 ESS68736.1 - 0.024 14.6 0.1 0.062 13.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1655) DUF1193 PF06702.7 ESS68737.1 - 2.5e-08 33.6 0.0 4.1e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1193) Dynein_heavy PF03028.10 ESS68738.1 - 9.3e-121 404.1 0.1 1.4e-120 403.5 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 ESS68738.1 - 2.2e-25 88.8 0.2 3.3e-25 88.2 0.1 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 ESS68739.1 - 6.9e-30 103.9 0.0 1e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 ESS68739.1 - 2.5e-22 79.0 8.3 3.6e-22 78.5 5.8 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Laminin_I PF06008.9 ESS68739.1 - 0.009 15.3 15.6 0.3 10.3 0.4 2.4 2 0 0 2 2 2 2 Laminin Domain I T2SF PF00482.18 ESS68739.1 - 0.014 15.2 4.8 0.21 11.4 1.7 2.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Tropomyosin PF00261.15 ESS68739.1 - 0.019 14.0 20.8 0.23 10.5 8.5 2.2 2 0 0 2 2 2 0 Tropomyosin AAA_13 PF13166.1 ESS68739.1 - 0.023 13.2 13.7 0.013 13.9 5.1 2.1 2 0 0 2 2 2 0 AAA domain Tropomyosin_1 PF12718.2 ESS68739.1 - 0.025 14.4 20.6 0.41 10.4 9.0 2.3 2 0 0 2 2 2 0 Tropomyosin like EIF4E-T PF10477.4 ESS68739.1 - 0.029 13.1 1.6 0.04 12.7 1.1 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Spc7 PF08317.6 ESS68739.1 - 0.037 12.6 16.1 0.078 11.6 7.5 2.7 3 0 0 3 3 3 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.7 ESS68739.1 - 0.053 13.2 20.3 0.37 10.5 0.5 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.4 ESS68739.1 - 0.13 12.0 18.4 0.061 13.1 0.6 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.7 ESS68739.1 - 0.14 11.8 10.6 4 7.2 5.4 2.5 2 0 0 2 2 2 0 Laminin Domain II Erp_C PF06780.6 ESS68739.1 - 0.26 11.1 13.2 0.65 9.8 0.8 2.5 2 0 0 2 2 2 0 Erp protein C-terminus Phage_GPO PF05929.6 ESS68739.1 - 0.3 10.2 11.1 0.093 11.9 5.4 1.7 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Casc1 PF12366.3 ESS68739.1 - 0.66 9.4 8.6 2.4 7.5 0.2 2.4 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 GRA6 PF05084.8 ESS68739.1 - 1.7 8.1 4.1 2.8 7.4 2.9 1.3 1 0 0 1 1 1 0 Granule antigen protein (GRA6) LOH1CR12 PF10158.4 ESS68739.1 - 1.8 8.3 10.2 4.2 7.1 1.3 3.7 2 1 2 4 4 4 0 Tumour suppressor protein Sipho_Gp157 PF05565.6 ESS68739.1 - 1.8 8.1 17.8 0.45 10.0 6.8 2.6 2 1 0 2 2 2 0 Siphovirus Gp157 AAA_23 PF13476.1 ESS68739.1 - 2.6 8.2 14.0 6.1 7.1 5.8 2.2 2 0 0 2 2 2 0 AAA domain V_ATPase_I PF01496.14 ESS68739.1 - 7.1 4.3 17.0 1.1e+02 0.4 11.8 2.0 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.5 ESS68739.1 - 7.4 6.6 14.2 2.9 8.0 6.5 2.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 ESS68739.1 - 9.5 6.0 13.7 3 7.6 0.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DHC_N2 PF08393.8 ESS68740.1 - 2.5e-115 385.2 4.5 3.5e-115 384.7 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS68740.1 - 1e-83 280.4 0.1 1.9e-82 276.2 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 ESS68740.1 - 5.8e-35 120.0 0.0 3.1e-21 75.5 0.0 4.7 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) DHC_N1 PF08385.7 ESS68740.1 - 7.5e-31 107.1 3.6 5.4e-30 104.3 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_7 PF12775.2 ESS68740.1 - 2.4e-21 76.0 0.2 2e-20 72.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_16 PF13191.1 ESS68740.1 - 1.1e-13 51.5 0.0 0.00047 20.2 0.0 4.2 3 0 0 3 3 3 3 AAA ATPase domain AAA PF00004.24 ESS68740.1 - 1.6e-11 44.5 0.0 0.012 15.8 0.0 4.1 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS68740.1 - 1.3e-10 41.5 0.2 0.0062 16.6 0.0 4.6 4 0 0 4 4 3 3 AAA domain AAA_17 PF13207.1 ESS68740.1 - 3.5e-08 34.2 0.0 0.0014 19.4 0.0 5.0 3 1 0 3 3 3 1 AAA domain DUF258 PF03193.11 ESS68740.1 - 8.1e-07 28.3 0.0 0.0037 16.4 0.0 3.8 3 0 0 3 3 3 1 Protein of unknown function, DUF258 AAA_28 PF13521.1 ESS68740.1 - 9e-07 28.9 0.1 0.22 11.4 0.0 3.8 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.1 ESS68740.1 - 1.3e-06 28.3 0.1 0.02 14.7 0.0 3.8 3 0 0 3 3 3 2 AAA domain ABC_tran PF00005.22 ESS68740.1 - 2.5e-06 27.8 0.0 0.011 16.0 0.0 3.4 2 0 0 2 2 2 1 ABC transporter Arch_ATPase PF01637.13 ESS68740.1 - 4e-06 26.7 0.0 0.11 12.1 0.0 3.5 3 0 0 3 3 3 2 Archaeal ATPase RNA_helicase PF00910.17 ESS68740.1 - 6.6e-06 26.2 0.0 3.3 7.9 0.0 3.7 3 0 0 3 3 3 1 RNA helicase AAA_30 PF13604.1 ESS68740.1 - 1e-05 25.1 0.1 0.051 13.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.1 ESS68740.1 - 1.8e-05 24.6 0.0 0.37 10.7 0.0 4.2 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 ESS68740.1 - 2.5e-05 23.9 0.7 0.23 11.2 0.0 3.6 3 0 0 3 3 3 1 Part of AAA domain NACHT PF05729.7 ESS68740.1 - 3.2e-05 23.6 0.8 0.12 11.9 0.0 3.2 3 0 0 3 3 3 2 NACHT domain Zeta_toxin PF06414.7 ESS68740.1 - 6.9e-05 22.0 1.3 0.14 11.2 0.0 4.2 4 0 0 4 4 4 1 Zeta toxin AAA_25 PF13481.1 ESS68740.1 - 0.00014 21.3 0.4 0.075 12.4 0.0 3.4 3 0 0 3 3 2 1 AAA domain UPF0079 PF02367.12 ESS68740.1 - 0.00018 21.1 0.1 0.52 9.9 0.0 3.7 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 ESS68740.1 - 0.00019 21.7 0.1 0.068 13.4 0.0 4.5 4 0 0 4 4 3 1 AAA domain Sigma54_activ_2 PF14532.1 ESS68740.1 - 0.00085 19.3 0.6 3.4 7.6 0.0 4.4 5 0 0 5 5 3 0 Sigma-54 interaction domain AAA_23 PF13476.1 ESS68740.1 - 0.0015 18.8 3.1 6.1 7.1 0.0 4.6 4 0 0 4 4 4 0 AAA domain MobB PF03205.9 ESS68740.1 - 0.0018 18.0 0.1 0.19 11.4 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Guanylate_kin PF00625.16 ESS68740.1 - 0.0031 16.9 0.7 1.2 8.5 0.0 3.3 3 0 0 3 3 3 1 Guanylate kinase CbiA PF01656.18 ESS68740.1 - 0.0035 16.7 0.0 6.4 6.1 0.0 3.4 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.12 ESS68740.1 - 0.0049 16.3 0.2 1.7 8.0 0.0 3.3 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_29 PF13555.1 ESS68740.1 - 0.0052 16.2 0.1 0.11 12.0 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_PrkA PF08298.6 ESS68740.1 - 0.0055 15.4 0.0 0.072 11.7 0.0 2.5 3 0 0 3 3 3 1 PrkA AAA domain cobW PF02492.14 ESS68740.1 - 0.0057 16.1 1.4 3.4 7.0 0.0 3.1 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.5 ESS68740.1 - 0.0076 15.4 0.1 0.2 10.8 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit T2SE PF00437.15 ESS68740.1 - 0.0076 15.1 0.5 0.23 10.3 0.0 2.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_21 PF13304.1 ESS68740.1 - 0.0083 16.1 0.0 0.039 13.9 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.1 ESS68740.1 - 0.013 15.1 0.3 22 4.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.16 ESS68740.1 - 0.017 14.3 1.3 2.8 7.0 0.0 2.7 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI DAP3 PF10236.4 ESS68740.1 - 0.022 13.6 0.1 4.8 6.0 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF4497 PF14924.1 ESS68740.1 - 0.043 14.1 0.0 0.2 11.9 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) AAA_10 PF12846.2 ESS68740.1 - 0.072 12.5 0.2 7.6 5.8 0.1 3.1 2 0 0 2 2 2 0 AAA-like domain ApoLp-III PF07464.6 ESS68740.1 - 0.12 12.4 1.3 0.84 9.6 0.9 2.4 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) ArgK PF03308.11 ESS68740.1 - 0.14 10.9 0.0 0.38 9.4 0.0 1.7 1 0 0 1 1 1 0 ArgK protein G-alpha PF00503.15 ESS68740.1 - 0.16 10.6 1.0 0.45 9.1 0.1 2.1 2 0 0 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.12 ESS68740.1 - 0.21 11.1 2.0 13 5.2 0.0 3.7 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 ESS68740.1 - 0.29 11.0 0.1 11 6.0 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rep_fac-A_C PF08646.5 ESS68741.1 - 7.5e-07 28.9 0.0 1.4e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Replication factor-A C terminal domain DUF1620 PF07774.8 ESS68743.1 - 5.4e-48 163.1 0.0 9.1e-48 162.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 ESS68743.1 - 7.3e-09 35.4 1.5 6e-07 29.1 0.1 3.4 3 1 1 4 4 4 1 PQQ-like domain PQQ PF01011.16 ESS68743.1 - 5.8e-05 22.4 0.0 1.8 8.2 0.0 4.3 4 0 0 4 4 4 2 PQQ enzyme repeat Gmad2 PF10648.4 ESS68743.1 - 0.031 14.4 0.2 0.16 12.1 0.1 2.2 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination LSM PF01423.17 ESS68743.1 - 0.068 12.7 0.2 0.16 11.5 0.1 1.7 1 0 0 1 1 1 0 LSM domain Abhydrolase_6 PF12697.2 ESS68744.1 - 8.8e-12 45.3 0.0 1.3e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS68744.1 - 0.049 13.3 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family PX PF00787.19 ESS68745.1 - 1e-10 41.3 0.7 7.3e-10 38.6 0.0 2.7 3 0 0 3 3 3 1 PX domain DUF2721 PF11026.3 ESS68745.1 - 0.25 10.9 1.1 0.5 10.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) GRIP PF01465.15 ESS68748.1 - 2.8e-12 45.9 0.0 6.2e-12 44.8 0.0 1.7 1 0 0 1 1 1 1 GRIP domain DUF4415 PF14384.1 ESS68748.1 - 0.044 13.9 0.0 0.18 11.9 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4415) DUF1515 PF07439.6 ESS68748.1 - 0.15 11.8 15.5 0.15 11.8 0.3 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) Borrelia_REV PF03978.8 ESS68748.1 - 0.46 10.1 9.7 0.032 13.9 0.8 2.9 2 1 0 3 3 3 0 Borrelia burgdorferi REV protein Reo_sigmaC PF04582.7 ESS68748.1 - 1.2 8.2 5.3 0.61 9.2 0.4 2.6 3 0 0 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 ESS68748.1 - 1.4 8.7 16.4 0.58 9.9 0.1 4.7 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) RmuC PF02646.11 ESS68748.1 - 1.7 7.3 23.3 0.065 12.0 1.1 4.1 4 0 0 4 4 4 0 RmuC family DUF948 PF06103.6 ESS68748.1 - 2.2 8.2 9.6 0.6 10.0 0.4 3.9 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Sas10_Utp3 PF04000.10 ESS68748.1 - 2.8 8.1 8.8 24 5.2 0.6 4.2 3 1 0 3 3 3 0 Sas10/Utp3/C1D family Bacillus_HBL PF05791.6 ESS68748.1 - 3.8 6.8 12.2 22 4.3 0.0 4.2 4 0 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) Fez1 PF06818.10 ESS68748.1 - 3.9 7.4 34.6 0.55 10.2 0.9 3.6 2 1 1 3 3 3 0 Fez1 PolyA_pol PF01743.15 ESS68748.1 - 5.4 7.2 13.4 4.5 7.5 1.6 3.3 2 1 1 3 3 3 0 Poly A polymerase head domain DUF16 PF01519.11 ESS68748.1 - 6.7 6.9 18.3 1.2 9.3 0.8 3.5 3 0 0 3 3 3 0 Protein of unknown function DUF16 Laminin_II PF06009.7 ESS68748.1 - 7.1 6.3 25.7 1.7 8.3 4.2 3.9 2 1 1 4 4 4 0 Laminin Domain II UCH PF00443.24 ESS68751.1 - 1.8e-37 128.9 0.0 3e-37 128.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS68751.1 - 3.2e-22 79.3 0.0 7.1e-22 78.2 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GAF_2 PF13185.1 ESS68752.1 - 0.00035 21.0 0.0 0.0051 17.3 0.0 2.4 2 0 0 2 2 2 1 GAF domain Rota_NSP3 PF01665.11 ESS68752.1 - 0.0085 15.0 0.1 0.015 14.2 0.1 1.3 1 0 0 1 1 1 1 Rotavirus non-structural protein NSP3 T4_Gp59_C PF08994.5 ESS68752.1 - 0.1 12.7 0.1 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term DUF561 PF04481.7 ESS68753.1 - 0.036 13.0 0.0 0.053 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Prenyltrans PF00432.16 ESS68754.1 - 8.7e-64 210.7 20.6 3.8e-13 48.7 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESS68754.1 - 1.9e-47 160.3 1.3 2.4e-18 66.5 0.0 3.3 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESS68754.1 - 2.3e-11 43.6 0.2 1.8e-05 24.7 0.1 3.4 1 1 2 3 3 3 2 Prenyltransferase-like NAD_binding_10 PF13460.1 ESS68755.1 - 2.8e-12 47.0 0.0 4.8e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESS68755.1 - 0.019 14.2 0.0 0.1 11.8 0.0 2.0 2 0 0 2 2 2 0 NmrA-like family Epimerase PF01370.16 ESS68755.1 - 0.026 13.9 0.0 0.099 12.0 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_C78 PF07910.8 ESS68756.1 - 1.8e-54 184.2 0.0 2.1e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C78 Rgp1 PF08737.5 ESS68757.1 - 6.3e-44 150.6 0.2 2.9e-41 141.9 0.0 2.9 1 1 1 2 2 2 2 Rgp1 Arrestin_C PF02752.17 ESS68757.1 - 0.0025 17.9 0.0 0.095 12.8 0.0 2.8 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Adaptin_N PF01602.15 ESS68758.1 - 4.9e-94 315.5 10.9 7.3e-94 314.9 7.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 ESS68758.1 - 3.9e-16 59.4 0.3 1e-15 58.0 0.2 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Arm PF00514.18 ESS68758.1 - 0.0013 18.4 1.5 6.1 6.8 0.0 4.8 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESS68758.1 - 0.0048 17.1 5.9 5 7.4 0.1 4.3 3 1 1 5 5 5 3 HEAT repeats HEAT PF02985.17 ESS68758.1 - 0.012 15.6 2.8 38 4.7 0.0 5.5 5 0 0 5 5 5 0 HEAT repeat HECT PF00632.20 ESS68759.1 - 2.9e-48 164.6 0.0 5.4e-48 163.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PI3_PI4_kinase PF00454.22 ESS68760.1 - 1.8e-47 161.8 0.3 4.6e-47 160.4 0.1 1.8 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESS68760.1 - 3.1e-27 95.4 0.7 8.3e-27 94.0 0.5 1.8 1 1 0 1 1 1 1 FAT domain DUF3385 PF11865.3 ESS68760.1 - 6.6e-22 78.1 1.9 1.5e-20 73.7 0.1 3.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) Rapamycin_bind PF08771.6 ESS68760.1 - 8.5e-22 77.1 0.3 6e-21 74.4 0.1 2.6 2 0 0 2 2 2 1 Rapamycin binding domain FATC PF02260.15 ESS68760.1 - 3.3e-15 55.1 0.1 8.9e-15 53.8 0.1 1.8 1 0 0 1 1 1 1 FATC domain PDZ PF00595.19 ESS68760.1 - 8.4e-07 29.0 0.1 2e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) HEAT_2 PF13646.1 ESS68760.1 - 2.7e-06 27.5 8.9 0.031 14.5 0.5 4.8 4 0 0 4 4 4 2 HEAT repeats PDZ_2 PF13180.1 ESS68760.1 - 3.6e-05 23.5 0.1 8.5e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain TPR_11 PF13414.1 ESS68760.1 - 0.00048 19.7 0.0 0.024 14.2 0.0 3.3 3 0 0 3 3 3 1 TPR repeat HEAT PF02985.17 ESS68760.1 - 0.0031 17.4 3.7 0.33 11.1 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat Tricorn_PDZ PF14685.1 ESS68760.1 - 0.074 12.8 0.1 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF3308 PF11751.3 ESS68760.1 - 0.18 11.0 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3308) NIF PF03031.13 ESS68762.1 - 2.4e-31 108.5 0.0 4.6e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.7 ESS68762.1 - 3.7e-08 32.7 0.0 5.2e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) HAD_2 PF13419.1 ESS68762.1 - 0.035 14.3 0.1 0.089 13.0 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HATPase_c PF02518.21 ESS68763.1 - 2.9e-16 59.1 0.0 4.8e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESS68763.1 - 2.5e-05 23.9 0.0 3.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 ESS68763.1 - 0.06 13.1 0.0 0.086 12.6 0.0 1.2 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Dynein_heavy PF03028.10 ESS68766.1 - 1.4e-221 737.4 0.0 3.1e-221 736.2 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 ESS68766.1 - 6.2e-143 477.2 0.7 6.2e-143 477.2 0.5 3.3 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 ESS68766.1 - 2e-119 398.7 4.1 2e-119 398.7 2.8 3.6 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS68766.1 - 2.3e-102 341.4 0.0 5.2e-102 340.2 0.0 1.7 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESS68766.1 - 1.3e-76 257.0 0.0 2.4e-76 256.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.2 ESS68766.1 - 1.5e-54 184.9 0.0 4.5e-54 183.3 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_9 PF12781.2 ESS68766.1 - 2.2e-47 160.8 0.0 4.6e-47 159.7 0.0 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS68766.1 - 3.4e-41 141.1 9.1 6.3e-41 140.2 6.3 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESS68766.1 - 4.1e-25 88.1 5.2 2e-06 27.5 0.0 7.6 7 1 0 7 7 6 4 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS68766.1 - 2.7e-07 30.7 0.6 0.93 9.6 0.0 5.5 5 0 0 5 5 4 2 AAA domain AAA PF00004.24 ESS68766.1 - 1.9e-06 28.0 3.1 0.63 10.2 0.0 5.7 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS68766.1 - 2.3e-05 24.4 16.0 0.26 11.2 0.0 7.4 7 2 1 8 8 6 2 AAA ATPase domain AAA_17 PF13207.1 ESS68766.1 - 7.4e-05 23.5 1.0 3.9 8.3 0.0 5.3 4 0 0 4 4 3 1 AAA domain ABC_tran PF00005.22 ESS68766.1 - 0.00023 21.4 2.2 1 9.6 0.0 4.3 5 0 0 5 5 3 2 ABC transporter AAA_29 PF13555.1 ESS68766.1 - 0.00055 19.4 0.2 0.076 12.5 0.0 3.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_30 PF13604.1 ESS68766.1 - 0.00067 19.2 4.9 2.8 7.4 0.0 4.5 5 0 0 5 5 5 2 AAA domain AAA_33 PF13671.1 ESS68766.1 - 0.0011 18.9 2.1 4.8 7.0 0.0 5.2 5 0 0 5 5 5 1 AAA domain DUF258 PF03193.11 ESS68766.1 - 0.0015 17.7 3.5 0.025 13.7 0.0 3.2 4 0 0 4 4 4 1 Protein of unknown function, DUF258 Sigma54_activat PF00158.21 ESS68766.1 - 0.01 15.3 0.1 1.8 8.0 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain MobB PF03205.9 ESS68766.1 - 0.02 14.6 0.2 5.1 6.7 0.1 3.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ESS68766.1 - 0.024 14.3 0.9 13 5.5 0.1 4.4 4 0 0 4 4 4 0 Part of AAA domain RNA_helicase PF00910.17 ESS68766.1 - 0.026 14.7 0.2 14 5.9 0.0 3.6 3 0 0 3 3 3 0 RNA helicase SMC_N PF02463.14 ESS68766.1 - 0.58 9.3 0.0 4 6.6 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESS68766.1 - 0.61 10.3 0.0 0.61 10.3 0.0 6.2 6 1 0 6 6 5 0 AAA domain TPR_11 PF13414.1 ESS68767.1 - 3.5e-14 52.1 9.6 1.3e-05 24.7 0.1 4.4 2 2 2 4 4 4 3 TPR repeat DnaJ PF00226.26 ESS68767.1 - 1.9e-13 49.9 0.2 4e-13 48.8 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 ESS68767.1 - 1.7e-05 24.3 12.8 0.43 10.6 0.1 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS68767.1 - 3.1e-05 23.3 6.4 2.1 8.1 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68767.1 - 0.00099 19.7 6.3 1.9 9.2 0.6 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68767.1 - 0.001 19.3 1.7 7.7 6.9 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS68767.1 - 0.039 13.7 0.1 26 4.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68767.1 - 0.27 11.9 9.4 13 6.7 0.2 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat MIP PF00230.15 ESS68768.1 - 7.8e-32 110.5 19.0 7.6e-31 107.3 13.2 2.0 1 1 0 1 1 1 1 Major intrinsic protein TPR_2 PF07719.12 ESS68769.1 - 0.00027 20.6 0.1 0.00038 20.1 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS68769.1 - 0.00039 20.0 0.0 0.0005 19.6 0.0 1.1 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 ESS68769.1 - 0.0014 19.2 0.0 0.002 18.7 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS68769.1 - 0.014 15.0 0.1 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS68769.1 - 0.098 13.3 0.0 0.15 12.7 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Apolipoprotein PF01442.13 ESS68770.1 - 0.029 13.8 0.1 0.032 13.7 0.1 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Apc3 PF12895.2 ESS68772.1 - 0.00049 20.1 2.2 0.051 13.7 0.1 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.27 ESS68774.1 - 7.4e-08 31.9 0.0 3.8e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Vps16_N PF04841.8 ESS68774.1 - 0.074 11.5 0.0 0.34 9.4 0.0 1.9 2 0 0 2 2 2 0 Vps16, N-terminal region PGM_PMM_I PF02878.11 ESS68775.1 - 6.7e-40 135.7 0.0 1.6e-39 134.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 ESS68775.1 - 7.5e-21 74.4 0.0 2.5e-20 72.7 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 ESS68775.1 - 1.4e-13 50.8 0.0 2.4e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 ESS68775.1 - 2e-05 24.5 0.0 5.7e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ribonucleas_3_3 PF14622.1 ESS68776.1 - 0.015 15.2 0.0 0.19 11.7 0.0 2.2 1 1 0 1 1 1 0 Ribonuclease-III-like Actin PF00022.14 ESS68777.1 - 3.8e-40 137.5 0.0 4.3e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 Actin C1_2 PF03107.11 ESS68778.1 - 0.0025 17.9 2.8 0.0025 17.9 1.9 2.2 3 0 0 3 3 3 1 C1 domain C1_3 PF07649.7 ESS68778.1 - 0.043 13.8 5.4 0.043 13.8 3.7 3.3 3 0 0 3 3 3 0 C1-like domain Elf1 PF05129.8 ESS68778.1 - 0.082 12.6 7.6 0.054 13.1 3.2 2.1 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_2 PF13240.1 ESS68778.1 - 0.7 9.4 8.6 0.1 12.1 1.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Aminotran_1_2 PF00155.16 ESS68779.1 - 1.9e-42 145.5 0.0 2.5e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Ins_P5_2-kin PF06090.7 ESS68780.1 - 4.5e-14 52.2 0.0 6.6e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase ATP-synt_ab PF00006.20 ESS68783.1 - 5e-109 362.8 0.0 8e-109 362.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESS68783.1 - 7.3e-26 90.8 0.2 1.2e-25 90.1 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESS68783.1 - 4.7e-14 52.3 1.7 4.7e-14 52.3 1.2 2.4 3 0 0 3 3 3 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.1 ESS68783.1 - 0.043 13.7 0.1 0.21 11.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.1 ESS68783.1 - 0.075 13.0 0.0 0.31 11.0 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain EMP70 PF02990.11 ESS68784.1 - 1.9e-45 155.3 22.5 2.5e-45 154.9 15.6 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 FUSC-like PF12805.2 ESS68784.1 - 3.3 6.5 5.6 2.1 7.2 2.5 1.6 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS EMP70 PF02990.11 ESS68785.1 - 1.7e-71 241.3 0.0 2.1e-71 241.0 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 WW PF00397.21 ESS68787.1 - 0.02 14.7 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 WW domain DUF3336 PF11815.3 ESS68788.1 - 5.6e-28 97.2 0.0 9.1e-28 96.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 ESS68788.1 - 2.5e-10 40.6 0.1 5.3e-10 39.5 0.0 1.6 2 0 0 2 2 2 1 Patatin-like phospholipase PfkB PF00294.19 ESS68789.1 - 4.6e-45 154.0 0.0 6e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CCDC155 PF14662.1 ESS68790.1 - 0.0074 15.9 21.7 0.0074 15.9 15.0 3.1 2 1 2 4 4 4 1 Coiled-coil region of CCDC155 APG6 PF04111.7 ESS68790.1 - 7 5.5 56.7 0.02 13.9 7.7 3.2 1 1 2 3 3 3 0 Autophagy protein Apg6 PI3_PI4_kinase PF00454.22 ESS68791.1 - 2.2e-33 115.7 0.0 3.4e-31 108.5 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.1 ESS68791.1 - 0.056 12.4 0.0 0.087 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) YMF19 PF02326.10 ESS68792.1 - 0.044 14.3 0.4 0.061 13.8 0.3 1.3 1 0 0 1 1 1 0 Plant ATP synthase F0 Ycf1 PF05758.7 ESS68794.1 - 0.84 7.2 9.2 1.3 6.6 6.4 1.2 1 0 0 1 1 1 0 Ycf1 Asp-B-Hydro_N PF05279.6 ESS68794.1 - 1.9 8.2 20.6 0.16 11.7 10.7 1.8 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region DUF4637 PF15470.1 ESS68794.1 - 2.4 7.7 16.0 4.6 6.8 6.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4637) CDC45 PF02724.9 ESS68794.1 - 3 5.7 11.8 5 5.0 8.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Borrelia_P83 PF05262.6 ESS68794.1 - 3.9 5.6 12.8 5.7 5.0 8.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.7 ESS68794.1 - 4 7.2 22.1 0.084 12.7 9.2 2.2 2 1 0 2 2 2 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.3 ESS68794.1 - 4.3 5.9 15.5 7.7 5.1 10.7 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 V_ATPase_I PF01496.14 ESS68794.1 - 9.9 3.8 7.4 14 3.3 5.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ank PF00023.25 ESS68795.1 - 2.4e-34 115.4 1.2 1.4e-08 34.0 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_2 PF12796.2 ESS68795.1 - 6.7e-33 112.9 1.5 3.9e-20 71.9 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESS68795.1 - 7e-26 87.7 0.8 2.1e-06 27.3 0.2 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 ESS68795.1 - 5.2e-23 80.5 6.4 4.9e-09 36.1 0.1 4.5 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS68795.1 - 2.3e-21 75.7 2.5 9.3e-07 29.2 0.3 5.3 2 1 3 5 5 5 5 Ankyrin repeats (many copies) PDCD2_C PF04194.8 ESS68796.1 - 4.2e-20 71.9 0.1 9.3e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Zn_Tnp_IS1595 PF12760.2 ESS68796.1 - 0.00011 21.9 0.3 0.65 9.8 0.0 2.9 2 0 0 2 2 2 2 Transposase zinc-ribbon domain DUF2296 PF10058.4 ESS68796.1 - 0.036 13.7 4.2 0.17 11.6 0.0 3.2 3 0 0 3 3 3 0 Predicted integral membrane metal-binding protein (DUF2296) zf-C2H2_4 PF13894.1 ESS68796.1 - 0.082 13.2 0.4 25 5.4 0.0 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-ISL3 PF14690.1 ESS68796.1 - 0.082 12.9 3.4 2.1 8.4 0.6 2.7 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Elf1 PF05129.8 ESS68796.1 - 0.092 12.4 4.8 0.13 12.0 0.4 2.7 2 2 0 2 2 2 0 Transcription elongation factor Elf1 like zf-ribbon_3 PF13248.1 ESS68796.1 - 0.26 10.5 6.9 1.1 8.5 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain PDGF PF00341.12 ESS68796.1 - 0.63 10.2 4.7 6.2 7.0 0.7 2.9 2 1 0 2 2 2 0 PDGF/VEGF domain TFIIS_C PF01096.13 ESS68796.1 - 0.8 9.3 0.1 0.8 9.3 0.0 3.8 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.5 ESS68796.1 - 0.8 9.7 4.8 13 5.8 0.0 3.4 3 0 0 3 3 3 0 Zinc ribbon domain PhnA_Zn_Ribbon PF08274.7 ESS68796.1 - 1.8 8.4 7.8 90 2.9 4.3 3.2 2 1 0 2 2 2 0 PhnA Zinc-Ribbon HEAT_2 PF13646.1 ESS68799.1 - 0.13 12.5 0.1 15 5.9 0.0 2.9 3 0 0 3 3 3 0 HEAT repeats Amino_oxidase PF01593.19 ESS68819.1 - 1.6e-13 50.5 0.0 2.3e-12 46.7 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 ESS68819.1 - 2e-10 40.5 0.4 5.1e-10 39.2 0.1 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 ESS68819.1 - 5.5e-05 23.3 0.0 0.00012 22.1 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESS68819.1 - 0.0031 16.4 0.0 0.0044 15.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESS68819.1 - 0.0051 16.7 0.0 0.023 14.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESS68819.1 - 0.061 13.7 0.0 0.15 12.5 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESS68819.1 - 0.07 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 ESS68819.1 - 0.095 12.4 0.1 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.9 ESS68819.1 - 0.14 10.5 0.0 0.19 10.1 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Aha1_N PF09229.6 ESS68820.1 - 7.1e-34 116.5 0.3 1.1e-33 115.9 0.2 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 ESS68820.1 - 5.1e-15 55.6 0.0 1e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein RRM_1 PF00076.17 ESS68821.1 - 3.1e-13 49.1 0.0 5.9e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68821.1 - 6.6e-12 45.2 0.0 1.2e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS68821.1 - 3.9e-05 23.4 0.0 7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) C2 PF00168.25 ESS68823.1 - 2e-13 49.9 0.2 9.4e-13 47.8 0.0 2.2 3 0 0 3 3 3 1 C2 domain DUF2404 PF10296.4 ESS68823.1 - 0.0058 16.7 0.0 0.27 11.3 0.0 3.0 2 1 1 3 3 3 1 Putative integral membrane protein conserved region (DUF2404) Proteasome PF00227.21 ESS68823.1 - 0.13 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Proteasome subunit Pkinase PF00069.20 ESS68825.1 - 3.1e-57 193.7 0.0 3.6e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68825.1 - 2e-21 76.2 0.0 3.6e-21 75.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS68825.1 - 0.00079 19.2 0.1 0.002 17.8 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 ESS68825.1 - 0.0013 17.5 0.1 0.0026 16.4 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.15 ESS68825.1 - 0.002 17.7 0.0 0.0039 16.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.9 ESS68825.1 - 0.092 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GAS PF13851.1 ESS68826.1 - 0.15 11.2 2.8 0.28 10.3 1.9 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CoaE PF01121.15 ESS68827.1 - 1.3e-24 86.5 1.1 2.7e-23 82.3 0.7 2.5 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.1 ESS68827.1 - 0.064 13.5 0.2 0.89 9.8 0.1 2.6 1 1 1 2 2 2 0 AAA domain MobB PF03205.9 ESS68827.1 - 0.065 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B COX2_TM PF02790.10 ESS68828.1 - 9.5 6.2 9.2 17 5.4 0.3 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain NTF2 PF02136.15 ESS68829.1 - 4.5e-07 30.2 0.0 7.9e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_6 PF14259.1 ESS68829.1 - 0.00033 20.5 0.0 0.00066 19.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS68829.1 - 0.012 15.2 0.0 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4379 PF14311.1 ESS68830.1 - 5.8e-24 83.6 8.0 5.6e-13 48.4 0.3 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4379) Zn_Tnp_IS1595 PF12760.2 ESS68830.1 - 0.0043 16.8 9.6 0.014 15.1 1.4 3.1 3 0 0 3 3 3 1 Transposase zinc-ribbon domain zf-ZPR1 PF03367.8 ESS68830.1 - 0.012 14.7 0.1 0.026 13.7 0.0 1.6 2 0 0 2 2 2 0 ZPR1 zinc-finger domain SprT-like PF10263.4 ESS68830.1 - 0.013 15.2 6.1 0.56 9.8 0.4 2.5 2 1 0 2 2 2 0 SprT-like family zf-C2H2_4 PF13894.1 ESS68830.1 - 0.39 11.1 10.8 13 6.3 0.2 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.5 ESS68830.1 - 2.5 8.1 8.1 8 6.5 0.7 3.2 3 0 0 3 3 3 0 Zinc ribbon domain Zn_Tnp_IS91 PF14319.1 ESS68830.1 - 2.9 7.4 5.6 4.7 6.7 0.1 2.8 3 0 0 3 3 3 0 Transposase zinc-binding domain zf-C3HC4_3 PF13920.1 ESS68830.1 - 3.3 7.4 7.0 0.97 9.1 0.3 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rubredoxin PF00301.15 ESS68830.1 - 6.7 6.6 9.4 5.7 6.9 0.5 3.2 3 0 0 3 3 3 0 Rubredoxin A2L_zn_ribbon PF08792.5 ESS68830.1 - 7 6.2 9.4 17 5.0 0.2 3.2 2 1 0 2 2 2 0 A2L zinc ribbon domain DUF4475 PF14753.1 ESS68831.1 - 2e-15 56.8 16.3 2.5e-11 43.4 1.3 2.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4475) NOB1_Zn_bind PF08772.6 ESS68831.1 - 0.019 14.7 3.8 0.019 14.7 2.7 3.1 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like Ribosomal_L33 PF00471.15 ESS68831.1 - 1.1 9.5 9.5 8.2 6.7 0.7 4.1 4 0 0 4 4 4 0 Ribosomal protein L33 ATP12 PF07542.6 ESS68832.1 - 2.2e-26 92.1 0.0 3.6e-26 91.5 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Peptidase_C13 PF01650.13 ESS68833.1 - 1.6e-34 119.4 0.0 1.9e-34 119.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family TTL PF03133.10 ESS68834.1 - 4.1e-60 203.1 0.1 5e-60 202.9 0.1 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESS68834.1 - 0.008 15.9 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain DUF3884 PF13024.1 ESS68834.1 - 0.0089 15.4 0.0 0.025 13.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3884) Nuc_sug_transp PF04142.10 ESS68837.1 - 1.6e-60 204.2 6.9 6.4e-60 202.2 3.6 2.1 2 0 0 2 2 2 1 Nucleotide-sugar transporter UAA PF08449.6 ESS68837.1 - 7.4e-07 28.3 5.5 7.4e-07 28.3 3.8 1.6 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 ESS68837.1 - 8.3e-07 28.7 7.2 8.3e-07 28.7 5.0 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESS68837.1 - 0.00013 22.0 25.4 0.00039 20.4 3.8 2.9 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 ESS68837.1 - 0.0026 17.9 6.6 0.0026 17.9 4.6 2.9 3 1 0 3 3 3 1 Multidrug resistance efflux transporter PAP2 PF01569.16 ESS68838.1 - 3.2e-20 72.1 1.7 3.2e-20 72.1 1.2 2.1 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 ESS68838.1 - 7.3e-05 22.3 0.2 0.0048 16.4 0.0 2.5 2 1 0 2 2 2 1 PAP2 superfamily GtrA PF04138.9 ESS68838.1 - 0.0011 18.9 3.7 0.0073 16.2 2.8 2.3 1 1 1 2 2 2 1 GtrA-like protein DUF3816 PF12822.2 ESS68838.1 - 0.022 14.6 0.7 0.022 14.6 0.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3816) DUF4199 PF13858.1 ESS68838.1 - 4.4 7.2 8.0 2.3 8.1 1.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) PAP2 PF01569.16 ESS68839.1 - 4e-22 78.2 2.5 9.5e-22 77.0 1.7 1.6 1 0 0 1 1 1 1 PAP2 superfamily DUF4199 PF13858.1 ESS68839.1 - 0.86 9.5 5.1 0.12 12.3 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) WD40 PF00400.27 ESS68840.1 - 1.7e-61 202.0 25.8 2.8e-11 42.8 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESS68840.1 - 0.00021 19.5 7.3 0.011 13.9 0.1 3.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF1513 PF07433.6 ESS68840.1 - 0.0016 17.3 0.2 1.1 8.1 0.0 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF1513) DUF3312 PF11768.3 ESS68840.1 - 0.052 11.7 0.2 0.89 7.7 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3312) UDG PF03167.14 ESS68841.1 - 2.1e-20 72.7 0.0 2.8e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily PPR_3 PF13812.1 ESS68842.1 - 0.0085 16.2 0.8 3.5 8.1 0.0 3.0 3 0 0 3 3 3 2 Pentatricopeptide repeat domain Arena_glycoprot PF00798.13 ESS68844.1 - 0.033 12.5 0.7 1.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Arenavirus glycoprotein Aconitase PF00330.15 ESS68845.1 - 4.6e-143 477.0 0.0 6e-143 476.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 ESS68845.1 - 2.2e-42 144.2 0.0 4e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain LXG PF04740.7 ESS68846.1 - 0.35 10.6 11.3 0.85 9.3 0.3 3.0 3 1 0 3 3 3 0 LXG domain of WXG superfamily PAS_9 PF13426.1 ESS68846.1 - 3.9 7.8 5.3 3 8.2 0.2 3.1 2 1 1 3 3 3 0 PAS domain ApoLp-III PF07464.6 ESS68846.1 - 6.1 6.8 18.7 0.15 12.1 6.2 2.5 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.6 ESS68846.1 - 6.1 6.7 8.4 1.2 9.0 0.3 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TBCC PF07986.7 ESS68847.1 - 5.5e-37 125.8 0.9 8.5e-37 125.2 0.7 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C FOP_dimer PF09398.5 ESS68847.1 - 7.1e-06 25.9 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 FOP N terminal dimerisation domain CAP_C PF08603.6 ESS68847.1 - 3.7e-05 23.1 0.0 5.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Arena_nucleocap PF00843.12 ESS68847.1 - 0.13 10.1 0.2 0.28 9.0 0.0 1.5 2 0 0 2 2 2 0 Arenavirus nucleocapsid protein YhdB PF14148.1 ESS68847.1 - 0.16 11.7 0.2 0.54 10.0 0.0 1.8 2 0 0 2 2 2 0 YhdB-like protein DUF1212 PF06738.7 ESS68848.1 - 6.3 6.2 9.7 5.3 6.4 1.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1212) Pox_M2 PF04887.7 ESS68849.1 - 0.013 14.8 0.1 0.18 11.0 0.0 2.1 2 0 0 2 2 2 0 Poxvirus M2 protein V-ATPase_C PF03223.10 ESS68850.1 - 3.7e-95 318.9 1.2 4.1e-95 318.8 0.8 1.0 1 0 0 1 1 1 1 V-ATPase subunit C BCIP PF13862.1 ESS68850.1 - 0.032 13.7 0.2 0.07 12.6 0.2 1.5 1 0 0 1 1 1 0 p21-C-terminal region-binding protein DUF1805 PF08827.6 ESS68850.1 - 0.1 12.3 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) Syntaxin PF00804.20 ESS68850.1 - 2.7 8.1 7.8 1.2 9.2 3.0 2.3 2 1 0 2 2 2 0 Syntaxin PapD-like PF14874.1 ESS68851.1 - 1.1e-08 34.9 1.6 0.0035 17.2 0.1 4.7 4 1 1 5 5 5 4 Flagellar-associated PapD-like Motile_Sperm PF00635.21 ESS68852.1 - 0.0032 17.0 0.0 0.016 14.8 0.0 2.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ECH PF00378.15 ESS68853.1 - 9.2e-40 136.2 0.3 3.4e-33 114.8 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase family RRM_1 PF00076.17 ESS68854.1 - 3e-15 55.5 0.0 6.3e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS68854.1 - 1.1e-12 47.7 0.0 2.1e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS68854.1 - 1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.13 ESS68855.1 - 1.7e-19 68.5 67.1 2e-07 30.0 1.3 7.5 7 1 1 8 8 8 5 Zn-finger in Ran binding protein and others FYVE PF01363.16 ESS68855.1 - 1.1e-17 63.6 10.7 1.1e-17 63.6 7.4 4.8 2 1 1 3 3 3 1 FYVE zinc finger DZR PF12773.2 ESS68855.1 - 0.14 12.0 56.5 0.1 12.4 6.3 5.7 1 1 5 6 6 6 0 Double zinc ribbon Peptidase_M41 PF01434.13 ESS68856.1 - 1.7e-45 155.1 1.2 2.3e-45 154.6 0.9 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESS68856.1 - 3.1e-24 85.6 0.1 6.1e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESS68856.1 - 0.0011 18.8 2.3 0.0017 18.3 0.5 2.1 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AA_kinase PF00696.23 ESS68856.1 - 0.024 14.1 2.1 0.54 9.7 0.0 2.7 1 1 1 3 3 3 0 Amino acid kinase family Peptidase_M50B PF13398.1 ESS68856.1 - 0.065 12.6 0.1 0.093 12.1 0.1 1.2 1 0 0 1 1 1 0 Peptidase M50B-like Pkinase PF00069.20 ESS68858.1 - 1.2e-77 260.5 0.0 1.4e-77 260.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68858.1 - 1.2e-41 142.4 0.0 1.5e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68858.1 - 7.8e-13 48.0 0.0 1.3e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS68858.1 - 7.6e-07 29.0 0.0 0.0069 16.1 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS68858.1 - 2.8e-06 26.5 0.1 4.8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.4 ESS68858.1 - 0.06 11.9 0.0 0.083 11.4 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF421 PF04239.7 ESS68858.1 - 0.17 11.4 1.1 0.41 10.2 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF421) DUF1444 PF07285.6 ESS68858.1 - 0.19 11.0 1.1 1.2 8.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1444) PA26 PF04636.8 ESS68859.1 - 5.2e-35 121.0 0.0 1.5e-21 76.6 0.0 2.2 1 1 0 2 2 2 2 PA26 p53-induced protein (sestrin) SelP_N PF04592.9 ESS68860.1 - 0.14 11.4 11.6 0.16 11.3 8.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NicO PF03824.11 ESS68860.1 - 0.31 10.3 7.9 0.36 10.0 5.5 1.0 1 0 0 1 1 1 0 High-affinity nickel-transport protein HEAT PF02985.17 ESS68861.1 - 2.3e-23 80.1 11.8 0.028 14.4 0.0 10.1 10 0 0 10 10 10 7 HEAT repeat HEAT_2 PF13646.1 ESS68861.1 - 2e-16 60.0 3.3 0.0007 19.8 0.0 6.7 3 1 5 8 8 8 6 HEAT repeats Cnd1 PF12717.2 ESS68861.1 - 0.012 15.5 0.6 16 5.3 0.0 4.1 2 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 ESS68861.1 - 0.02 15.2 0.1 18 5.7 0.0 4.6 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region DNA_alkylation PF08713.6 ESS68861.1 - 0.025 14.0 0.1 0.12 11.9 0.0 2.2 2 0 0 2 2 2 0 DNA alkylation repair enzyme HEAT_EZ PF13513.1 ESS68861.1 - 0.099 13.1 3.6 33 5.1 0.0 5.0 6 0 0 6 6 6 0 HEAT-like repeat Citrate_synt PF00285.16 ESS68863.1 - 1.5e-95 319.9 0.0 1.9e-95 319.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase GTP_EFTU PF00009.22 ESS68866.1 - 4.6e-57 192.5 0.1 7.8e-57 191.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESS68866.1 - 1.3e-19 70.1 0.1 6.1e-18 64.8 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESS68866.1 - 1.6e-05 24.8 0.3 4.1e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESS68866.1 - 0.00058 19.8 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.1 ESS68866.1 - 0.12 11.9 0.0 0.37 10.3 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fe-ADH PF00465.14 ESS68867.1 - 2.9e-118 394.7 5.0 3.3e-118 394.5 3.4 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 ESS68867.1 - 7.1e-20 71.3 2.3 3.3e-17 62.6 1.6 2.2 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Lamprin PF06403.6 ESS68867.1 - 0.0025 17.5 1.1 0.0062 16.2 0.8 1.7 1 0 0 1 1 1 1 Lamprin Inositol_P PF00459.20 ESS68867.1 - 0.045 13.0 0.3 0.24 10.6 0.0 2.1 2 0 0 2 2 2 0 Inositol monophosphatase family DUF1508 PF07411.7 ESS68867.1 - 0.15 11.4 0.4 1.1 8.6 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1508) DUF3782 PF12644.2 ESS68868.1 - 0.11 12.3 4.3 0.35 10.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) PDZ_2 PF13180.1 ESS68869.1 - 0.0056 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 ESS68869.1 - 0.047 13.8 0.0 0.49 10.5 0.0 2.4 2 0 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 ESS68869.1 - 0.071 12.9 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain RNA_pol_Rpb5_C PF01191.14 ESS68870.1 - 1.9e-26 91.4 0.1 4.5e-26 90.2 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 ESS68870.1 - 4.2e-07 30.2 0.4 2e-05 24.9 0.3 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Ribosomal_S8 PF00410.14 ESS68871.1 - 8.9e-10 38.5 0.0 1.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S8 UPF0258 PF06789.7 ESS68871.1 - 0.094 12.7 0.1 0.15 12.0 0.1 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0258) CDP-OH_P_transf PF01066.16 ESS68872.1 - 6.5e-21 74.5 4.0 6.5e-21 74.5 2.7 1.8 1 1 1 2 2 2 1 CDP-alcohol phosphatidyltransferase HEAT_EZ PF13513.1 ESS68873.1 - 0.026 15.0 9.4 0.3 11.6 0.1 6.2 7 1 1 8 8 8 0 HEAT-like repeat Cnd1 PF12717.2 ESS68874.1 - 0.0021 17.9 0.0 0.0081 16.0 0.0 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 ESS68874.1 - 0.0057 17.0 1.1 0.19 12.1 0.0 3.8 3 1 2 5 5 5 1 Vacuolar 14 Fab1-binding region DUF4447 PF14590.1 ESS68874.1 - 0.062 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4447) WD40 PF00400.27 ESS68875.1 - 2.1e-35 119.3 18.6 1.8e-08 33.8 0.0 12.7 14 0 0 14 14 14 8 WD domain, G-beta repeat Utp12 PF04003.7 ESS68875.1 - 6.7e-06 25.9 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family PD40 PF07676.7 ESS68875.1 - 0.093 12.4 0.3 13 5.6 0.0 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Metallophos PF00149.23 ESS68879.1 - 5.8e-12 45.4 2.4 1.7e-11 43.8 1.7 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESS68879.1 - 1.7e-08 34.4 0.1 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Miro PF08477.8 ESS68880.1 - 0.026 14.9 0.0 0.058 13.8 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein Viral_helicase1 PF01443.13 ESS68880.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_32 PF13654.1 ESS68880.1 - 0.15 10.6 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 ESS68880.1 - 0.34 10.7 0.1 0.69 9.7 0.0 1.5 1 0 0 1 1 1 0 Dynamin family ATP_bind_1 PF03029.12 ESS68880.1 - 0.35 10.3 0.1 0.65 9.4 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Pro_isomerase PF00160.16 ESS68884.1 - 2e-39 135.2 0.0 3.2e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Glyco_trans_1_4 PF13692.1 ESS68885.1 - 9.8e-12 45.1 0.0 2.4e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESS68885.1 - 0.15 12.3 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 PPR_3 PF13812.1 ESS68886.1 - 3.7e-06 26.7 3.6 1.5 9.3 0.0 4.7 4 0 0 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.15 ESS68886.1 - 0.0045 16.8 0.5 17 5.6 0.0 4.4 4 0 0 4 4 4 1 PPR repeat PPR_2 PF13041.1 ESS68886.1 - 0.0066 16.3 0.1 1.5 8.8 0.0 3.6 2 2 2 4 4 4 1 PPR repeat family ParcG PF10274.4 ESS68886.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 Parkin co-regulated protein WD40 PF00400.27 ESS68887.1 - 9.8e-26 88.6 11.6 1.6e-06 27.7 0.4 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat Myosin_TH1 PF06017.8 ESS68888.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Myosin tail CAP_N PF01213.14 ESS68889.1 - 0.00049 19.4 0.8 0.00061 19.1 0.6 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal DUF3138 PF11336.3 ESS68889.1 - 0.0039 15.4 0.5 0.0039 15.4 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3138) ERM PF00769.14 ESS68889.1 - 0.011 15.2 21.4 0.52 9.7 14.9 2.2 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Spc7 PF08317.6 ESS68889.1 - 0.19 10.3 8.2 0.33 9.5 5.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.4 ESS68889.1 - 0.78 9.9 6.2 0.35 11.0 1.2 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lebercilin PF15619.1 ESS68889.1 - 1.6 8.0 22.7 0.67 9.3 13.5 1.9 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.5 ESS68889.1 - 1.9 8.5 7.7 9.5 6.3 4.9 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.14 ESS68889.1 - 2.2 6.0 4.3 2.5 5.8 3.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.1 ESS68889.1 - 4.1 6.2 11.3 7.7 5.3 7.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF342 PF03961.8 ESS68889.1 - 4.7 5.4 10.6 1.8 6.8 4.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF342) FlxA PF14282.1 ESS68889.1 - 7.3 6.5 13.0 11 6.0 2.8 2.4 1 1 1 2 2 2 0 FlxA-like protein IncA PF04156.9 ESS68889.1 - 7.5 6.1 20.1 4.8 6.7 11.4 2.0 2 0 0 2 2 2 0 IncA protein FemAB PF02388.11 ESS68889.1 - 9.7 4.7 9.7 5.3 5.6 2.4 2.0 1 1 1 2 2 2 0 FemAB family Nrap PF03813.9 ESS68890.1 - 3.8e-52 177.0 0.0 1.1e-49 168.9 0.0 2.6 2 1 0 2 2 2 2 Nrap protein Nrap PF03813.9 ESS68891.1 - 0.001 16.7 0.0 0.0011 16.5 0.0 1.1 1 0 0 1 1 1 1 Nrap protein Sigma70_r3 PF04539.11 ESS68892.1 - 0.0061 16.4 0.0 4.4 7.2 0.0 2.4 2 0 0 2 2 2 2 Sigma-70 region 3 Zn-ribbon_8 PF09723.5 ESS68892.1 - 1.1 9.3 5.3 0.98 9.4 0.4 2.9 3 0 0 3 3 3 0 Zinc ribbon domain Mannosyl_trans2 PF04188.8 ESS68893.1 - 2.2e-35 122.4 31.9 7.6e-28 97.6 17.3 2.3 2 1 0 2 2 2 2 Mannosyltransferase (PIG-V)) FANCI_S1-cap PF14674.1 ESS68894.1 - 0.017 15.1 0.0 0.051 13.6 0.0 1.8 1 0 0 1 1 1 0 FANCI solenoid 1 cap IQ PF00612.22 ESS68894.1 - 0.021 14.4 10.8 1.2 8.9 3.8 3.7 3 0 0 3 3 3 0 IQ calmodulin-binding motif UDPGP PF01704.13 ESS68895.1 - 1.1e-90 304.1 0.0 1.5e-90 303.7 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Mito_carr PF00153.22 ESS68896.1 - 3.9e-28 97.0 0.3 3.4e-14 52.3 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF543 PF04418.7 ESS68896.1 - 1.1 9.2 4.0 7.6 6.5 0.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF543) Toxin_32 PF08120.6 ESS68897.1 - 0.29 10.7 1.8 0.87 9.2 1.2 1.8 1 0 0 1 1 1 0 Tamulustoxin family SR-25 PF10500.4 ESS68898.1 - 0.00087 18.8 10.9 0.0014 18.1 7.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RAP1 PF07218.6 ESS68898.1 - 0.33 9.0 6.8 0.5 8.4 4.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.4 ESS68898.1 - 0.43 9.3 5.9 0.63 8.8 4.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Corona_nucleoca PF00937.13 ESS68898.1 - 4.7 6.0 10.7 7 5.4 7.4 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Macoilin PF09726.4 ESS68898.1 - 6.2 4.9 8.5 8.4 4.5 5.9 1.1 1 0 0 1 1 1 0 Transmembrane protein PhoD PF09423.5 ESS68900.1 - 5.9e-18 64.6 0.0 7.6e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase Hydantoinase_B PF02538.9 ESS68901.1 - 4e-177 589.6 0.0 1.4e-174 581.2 0.0 2.1 2 0 0 2 2 2 2 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 ESS68901.1 - 8e-86 287.7 1.3 1.2e-85 287.2 0.0 2.0 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 ESS68901.1 - 3.5e-49 166.6 0.1 1.4e-45 154.9 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region CTV_P13 PF06922.6 ESS68901.1 - 0.032 14.0 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 Citrus tristeza virus P13 protein DnaJ PF00226.26 ESS68902.1 - 0.01 15.5 0.0 0.085 12.6 0.0 2.3 2 0 0 2 2 2 0 DnaJ domain Kinase-like PF14531.1 ESS68903.1 - 0.059 12.3 0.0 0.096 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like zf-C2H2_jaz PF12171.3 ESS68904.1 - 4.7e-05 23.3 1.2 7.2e-05 22.7 0.8 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESS68904.1 - 0.012 15.7 1.8 0.018 15.2 1.2 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-U1 PF06220.7 ESS68904.1 - 0.07 12.7 0.6 0.1 12.1 0.4 1.2 1 0 0 1 1 1 0 U1 zinc finger TEX13 PF15186.1 ESS68905.1 - 0.16 11.5 0.2 0.16 11.5 0.2 2.3 1 1 0 2 2 2 0 Testis-expressed sequence 13 protein family Tctex-1 PF03645.8 ESS68906.1 - 2.5e-27 94.6 0.1 3.5e-27 94.2 0.1 1.2 1 0 0 1 1 1 1 Tctex-1 family RNA_pol_Rpb5_C PF01191.14 ESS68907.1 - 2.1e-29 100.9 0.1 3.7e-29 100.1 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 ESS68907.1 - 4.6e-24 84.6 0.8 1.1e-23 83.4 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain TrbC_Ftype PF09673.5 ESS68907.1 - 0.055 13.0 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Ribosomal_S27e PF01667.12 ESS68908.1 - 1.2e-23 82.3 3.7 1.6e-23 81.9 2.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 ESS68908.1 - 0.0005 19.8 1.9 0.0006 19.6 1.3 1.2 1 0 0 1 1 1 1 IBR domain Elf1 PF05129.8 ESS68908.1 - 0.039 13.6 1.5 0.056 13.1 1.0 1.2 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like TF_Zn_Ribbon PF08271.7 ESS68908.1 - 0.07 12.4 0.8 0.11 11.8 0.5 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding Zn_Tnp_IS1 PF03811.8 ESS68908.1 - 0.13 11.8 3.3 0.4 10.2 2.3 1.9 1 1 0 1 1 1 0 InsA N-terminal domain FYVE_2 PF02318.11 ESS68908.1 - 0.14 12.0 0.9 0.17 11.8 0.6 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger zinc_ribbon_4 PF13717.1 ESS68908.1 - 0.19 11.4 3.1 3.8 7.3 2.1 2.4 1 1 0 1 1 1 0 zinc-ribbon domain Yippee-Mis18 PF03226.9 ESS68908.1 - 0.21 11.6 2.7 3.5 7.7 0.0 2.1 1 1 2 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_5 PF13719.1 ESS68908.1 - 0.35 10.4 3.4 5.7 6.6 2.3 2.4 1 1 0 1 1 1 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 ESS68908.1 - 0.58 9.8 4.2 0.66 9.6 1.6 1.8 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-LSD1 PF06943.7 ESS68908.1 - 4.3 7.0 6.9 15 5.2 0.0 3.1 3 0 0 3 3 3 0 LSD1 zinc finger zf-ISL3 PF14690.1 ESS68908.1 - 6.6 6.8 6.3 1.2 9.2 0.6 2.4 2 1 1 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Robl_LC7 PF03259.12 ESS68909.1 - 4.8e-21 74.1 0.0 5.5e-21 73.9 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain VHS PF00790.14 ESS68934.1 - 3.3e-15 55.9 0.0 1.9e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 VHS domain HipA_C PF07804.7 ESS68934.1 - 0.048 13.7 0.1 0.16 12.1 0.0 2.0 1 1 0 1 1 1 0 HipA-like C-terminal domain PsiA PF06952.6 ESS68934.1 - 0.048 12.7 1.4 0.084 11.9 1.0 1.3 1 0 0 1 1 1 0 PsiA protein Kinesin PF00225.18 ESS68935.1 - 8.1e-26 90.5 0.0 1.9e-18 66.2 0.0 2.7 2 0 0 2 2 2 2 Kinesin motor domain YebG PF07130.7 ESS68935.1 - 0.013 15.1 2.6 0.044 13.4 1.8 1.9 1 0 0 1 1 1 0 YebG protein MA3 PF02847.12 ESS68936.1 - 2e-12 46.8 0.5 4.6e-12 45.6 0.3 1.7 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.14 ESS68936.1 - 2.3e-09 36.9 0.0 4.8e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 MIF4G domain VPS28 PF03997.7 ESS68937.1 - 1.8e-43 148.3 0.3 2.1e-43 148.1 0.2 1.0 1 0 0 1 1 1 1 VPS28 protein DUF1759 PF03564.10 ESS68937.1 - 0.3 10.9 1.9 3.9 7.2 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1759) Aldedh PF00171.17 ESS68938.1 - 2e-131 438.5 1.2 2.5e-131 438.2 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ESS68938.1 - 0.015 14.5 0.1 0.15 11.2 0.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) IF4E PF01652.13 ESS68938.1 - 0.03 13.8 0.1 0.052 13.0 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic initiation factor 4E SNF2_N PF00176.18 ESS68939.1 - 1.4e-70 237.4 0.0 2.4e-70 236.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS68939.1 - 2.3e-15 56.1 0.1 6.4e-15 54.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS68939.1 - 9.8e-07 28.7 0.0 2.2e-05 24.3 0.0 2.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 ESS68939.1 - 3.7e-05 23.2 0.0 8.4e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS68939.1 - 0.022 14.8 0.1 0.17 12.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain Apc4_WD40 PF12894.2 ESS68939.1 - 0.2 11.1 1.6 1.9 8.0 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 ESS68942.1 - 0.0038 17.0 1.5 3.6 7.6 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat TAF8_C PF10406.4 ESS68943.1 - 0.035 14.1 0.3 0.059 13.4 0.2 1.3 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term PRKCSH PF07915.8 ESS68944.1 - 1.9e-13 51.0 0.0 2.2e-12 47.5 0.0 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.1 ESS68944.1 - 0.028 13.8 1.7 0.061 12.8 1.2 1.7 1 1 0 1 1 1 0 Glucosidase II beta subunit-like protein RskA PF10099.4 ESS68945.1 - 0.002 17.8 0.1 1.2 8.8 0.0 2.3 2 0 0 2 2 2 2 Anti-sigma-K factor rskA Glyco_hydro_65m PF03632.10 ESS68946.1 - 1.6e-66 224.5 0.0 1.6e-66 224.5 0.0 1.6 2 0 0 2 2 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 ESS68946.1 - 2.3e-22 79.5 2.7 1.2e-21 77.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain HAD_2 PF13419.1 ESS68946.1 - 1.5e-05 25.3 0.0 4.6e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Glyco_hydro_65C PF03633.10 ESS68946.1 - 0.00063 19.7 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain Spt20 PF12090.3 ESS68946.1 - 0.0057 16.0 1.2 0.011 15.0 0.9 1.4 1 0 0 1 1 1 1 Spt20 family Med15 PF09606.5 ESS68946.1 - 0.026 12.7 19.5 0.038 12.1 13.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 ESS68946.1 - 0.026 14.2 2.8 0.045 13.4 1.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hydrolase PF00702.21 ESS68946.1 - 0.033 14.6 0.0 0.23 11.8 0.0 2.4 2 1 0 2 2 1 0 haloacid dehalogenase-like hydrolase Folate_carrier PF01770.13 ESS68946.1 - 0.18 10.2 1.0 0.29 9.5 0.7 1.2 1 0 0 1 1 1 0 Reduced folate carrier PAT1 PF09770.4 ESS68946.1 - 0.37 8.9 14.1 0.55 8.3 9.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cyclin_N PF00134.18 ESS68946.1 - 0.84 9.2 7.1 2 8.0 3.8 2.3 2 0 0 2 2 2 0 Cyclin, N-terminal domain DUF605 PF04652.11 ESS68946.1 - 2.6 7.3 12.5 4.1 6.7 8.6 1.1 1 0 0 1 1 1 0 Vta1 like Agouti PF05039.7 ESS68946.1 - 2.9 8.2 8.9 2.7 8.3 0.3 2.7 2 0 0 2 2 2 0 Agouti protein ADIP PF11559.3 ESS68947.1 - 1.1e-05 25.4 7.5 1.1e-05 25.4 5.2 12.0 11 2 1 13 13 13 3 Afadin- and alpha -actinin-Binding DASH_Dam1 PF08653.5 ESS68948.1 - 0.045 13.5 0.4 0.045 13.5 0.3 3.5 5 0 0 5 5 5 0 DASH complex subunit Dam1 AAA_23 PF13476.1 ESS68948.1 - 7.3 6.8 14.1 12 6.0 4.2 3.1 3 1 0 3 3 3 0 AAA domain Sec20 PF03908.8 ESS68948.1 - 8.1 6.2 9.7 3.6 7.3 3.1 3.0 2 0 0 2 2 2 0 Sec20 Adaptin_N PF01602.15 ESS68949.1 - 8.9e-37 126.5 0.0 1.1e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Arm PF00514.18 ESS68949.1 - 0.11 12.3 1.6 0.68 9.8 0.2 2.5 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Exo_endo_phos PF03372.18 ESS68950.1 - 8e-15 55.4 0.1 2e-14 54.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VWA_CoxE PF05762.9 ESS68950.1 - 0.04 13.0 0.2 0.77 8.8 0.1 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein HATPase_c_4 PF13749.1 ESS68950.1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent DNA helicase recG C-terminal HEAT_2 PF13646.1 ESS68951.1 - 0.0002 21.5 7.8 0.37 11.1 0.0 5.2 4 2 2 6 6 6 3 HEAT repeats HEAT PF02985.17 ESS68951.1 - 0.0068 16.3 12.1 0.23 11.6 0.1 5.7 6 0 0 6 6 6 2 HEAT repeat RNHCP PF12647.2 ESS68951.1 - 0.17 11.7 0.7 8.1 6.3 0.1 2.7 2 0 0 2 2 2 0 RNHCP domain GST_C_2 PF13410.1 ESS68955.1 - 4.7e-09 36.0 0.0 1.3e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESS68955.1 - 1e-05 25.9 0.0 2.9e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ESS68955.1 - 0.013 15.4 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribosomal_L9_N PF01281.14 ESS68955.1 - 0.071 12.3 0.1 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L9, N-terminal domain COG2 PF06148.6 ESS68956.1 - 7.1e-45 152.1 0.5 7.1e-45 152.1 0.3 2.7 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.3 ESS68956.1 - 1.7e-22 79.8 0.4 2.2e-20 73.0 0.0 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3510) IGF2_C PF08365.6 ESS68957.1 - 0.1 12.3 4.1 0.36 10.6 2.8 1.9 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide LRR_1 PF00560.28 ESS68957.1 - 0.12 12.4 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Leucine Rich Repeat MIF4G PF02854.14 ESS68958.1 - 2.3e-30 105.5 1.3 4.1e-30 104.7 0.9 1.4 1 0 0 1 1 1 1 MIF4G domain Zip PF02535.17 ESS68958.1 - 0.0076 15.2 12.2 0.012 14.6 8.5 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4638 PF15472.1 ESS68958.1 - 0.018 14.6 7.3 0.039 13.5 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Activator_LAG-3 PF11498.3 ESS68958.1 - 0.027 13.2 33.7 0.04 12.6 23.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PAT1 PF09770.4 ESS68958.1 - 0.15 10.3 23.4 0.21 9.7 16.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.2 ESS68958.1 - 0.16 9.6 5.8 0.3 8.7 4.0 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4175 PF13779.1 ESS68958.1 - 2.1 5.9 26.0 3 5.4 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF1911 PF08929.5 ESS68958.1 - 2.9 8.6 11.4 1.7e+02 2.8 9.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) DUF1632 PF07857.7 ESS68959.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 CEO family (DUF1632) Pkinase PF00069.20 ESS68962.1 - 1.1e-56 191.9 0.0 1.6e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS68962.1 - 5.3e-34 117.4 0.0 9.1e-34 116.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS68962.1 - 1.8e-09 37.0 0.0 3.9e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS68962.1 - 8.2e-06 25.7 0.2 0.16 11.7 0.0 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS68962.1 - 0.009 15.0 0.0 0.038 13.0 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2_jaz PF12171.3 ESS68962.1 - 0.033 14.3 2.8 0.068 13.3 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Seadorna_VP7 PF07387.6 ESS68962.1 - 0.13 11.1 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 C1_3 PF07649.7 ESS68962.1 - 0.52 10.3 12.1 0.057 13.4 5.1 1.9 2 0 0 2 2 2 0 C1-like domain ZZ PF00569.12 ESS68962.1 - 1.1 8.8 12.7 0.028 13.9 3.9 2.1 2 0 0 2 2 2 0 Zinc finger, ZZ type Elf1 PF05129.8 ESS68962.1 - 2.8 7.6 9.2 3.1 7.5 3.4 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like FYVE_2 PF02318.11 ESS68962.1 - 4 7.3 8.8 1.7 8.5 4.0 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger Ubie_methyltran PF01209.13 ESS68963.1 - 1.1e-94 315.9 0.0 1.3e-94 315.7 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 ESS68963.1 - 2.4e-14 53.5 0.0 5e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS68963.1 - 6.4e-11 42.0 0.0 9.6e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS68963.1 - 3.3e-09 37.0 0.0 6.9e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS68963.1 - 2.4e-07 31.1 0.0 4.5e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS68963.1 - 3.9e-07 29.9 0.0 5.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS68963.1 - 0.00034 21.1 0.0 0.00061 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESS68963.1 - 0.006 16.2 0.0 0.018 14.7 0.0 1.7 2 0 0 2 2 2 1 Hypothetical methyltransferase API5 PF05918.6 ESS68964.1 - 3.6 5.9 5.3 23 3.3 4.6 1.6 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) WD40 PF00400.27 ESS68967.1 - 5.7e-24 83.0 7.0 4e-07 29.6 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat PQQ_2 PF13360.1 ESS68967.1 - 1.3e-07 31.3 0.0 0.00013 21.4 0.0 3.1 2 1 0 2 2 2 2 PQQ-like domain Nup160 PF11715.3 ESS68967.1 - 0.021 12.9 0.1 0.72 7.9 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Arrestin_N PF00339.24 ESS68968.1 - 5.8e-07 29.4 0.1 3.1e-06 27.0 0.0 2.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESS68968.1 - 0.00042 20.4 0.0 0.0033 17.5 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.2 ESS68968.1 - 0.011 15.2 0.1 0.024 14.1 0.0 1.5 2 0 0 2 2 2 0 Arrestin_N terminal like Sld5 PF05916.6 ESS68969.1 - 1.5e-18 67.0 0.0 2.3e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Glycos_transf_4 PF00953.16 ESS68970.1 - 3.1e-36 124.5 11.2 3.1e-36 124.5 7.7 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 4 GFA PF04828.9 ESS68973.1 - 0.71 9.8 5.5 0.94 9.4 0.4 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.2 ESS68973.1 - 3.7 7.4 7.7 13 5.7 0.1 2.5 2 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESS68973.1 - 4.4 6.6 7.4 2.8 7.2 0.0 2.7 3 0 0 3 3 3 0 zinc-ribbon domain Diacid_rec PF05651.8 ESS68974.1 - 0.0013 18.1 0.3 0.0027 17.1 0.2 1.4 1 0 0 1 1 1 1 Putative sugar diacid recognition DUF92 PF01940.11 ESS68975.1 - 0.041 13.0 0.2 0.063 12.4 0.2 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF92 LRR_6 PF13516.1 ESS68976.1 - 2.4e-05 23.9 0.0 0.61 10.3 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 ESS68976.1 - 8e-05 22.1 0.0 0.37 10.4 0.0 2.9 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS68976.1 - 0.00025 20.6 0.4 6.7 7.1 0.0 4.0 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_7 PF13504.1 ESS68976.1 - 0.016 15.3 0.0 14 6.4 0.0 3.9 3 0 0 3 3 3 0 Leucine rich repeat LIM_bind PF01803.11 ESS68976.1 - 0.059 12.4 2.8 1.3 8.0 1.9 2.2 1 1 1 2 2 2 0 LIM-domain binding protein DUF1703 PF08011.6 ESS68976.1 - 0.67 9.7 3.3 1.5 8.5 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1703) Glyco_hydro_31 PF01055.21 ESS68977.1 - 3.2e-94 316.2 0.0 4e-94 315.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 IQ PF00612.22 ESS68979.1 - 3e-13 48.1 14.4 3.4e-05 23.0 0.7 3.7 3 0 0 3 3 3 3 IQ calmodulin-binding motif DUF2362 PF10154.4 ESS68979.1 - 0.0024 16.6 0.3 0.0035 16.0 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) NTase_sub_bind PF08780.6 ESS68979.1 - 0.0074 16.0 0.9 2.3 7.9 0.0 2.7 3 0 0 3 3 3 2 Nucleotidyltransferase substrate binding protein like Aminotran_1_2 PF00155.16 ESS68979.1 - 0.018 13.9 0.7 0.038 12.9 0.4 1.4 1 1 0 1 1 1 0 Aminotransferase class I and II YtxH PF12732.2 ESS68979.1 - 1.1 9.6 6.4 5.2 7.5 0.1 2.6 2 1 0 2 2 2 0 YtxH-like protein Toxin_43 PF15604.1 ESS68979.1 - 1.7 8.6 6.2 0.31 11.0 0.7 2.3 3 0 0 3 3 3 0 Putative toxin 43 His_Phos_1 PF00300.17 ESS68980.1 - 9.9e-15 54.9 0.0 5.5e-14 52.5 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RCC1 PF00415.13 ESS68981.1 - 5.3e-33 112.9 12.4 1.9e-10 40.7 0.0 7.0 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS68981.1 - 2.5e-14 52.4 28.8 0.00013 21.4 0.3 7.5 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat TPR_12 PF13424.1 ESS68982.1 - 4.3e-10 39.3 3.1 0.00079 19.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESS68982.1 - 1e-07 31.2 5.7 0.00047 19.8 0.4 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS68982.1 - 1.4e-07 30.8 1.3 0.0009 18.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS68982.1 - 2e-06 27.1 1.9 0.0096 15.5 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS68982.1 - 2e-05 24.1 6.0 0.00032 20.2 0.6 3.2 2 1 0 2 2 2 1 TPR repeat TPR_14 PF13428.1 ESS68982.1 - 0.00084 19.7 4.6 0.13 12.9 0.2 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS68982.1 - 0.0011 19.5 5.6 0.022 15.4 1.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS68982.1 - 0.0011 18.5 0.6 0.036 13.8 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS68982.1 - 0.0082 16.4 0.2 0.0082 16.4 0.1 2.9 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS68982.1 - 0.0092 16.3 0.4 0.082 13.3 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS68982.1 - 0.019 14.8 3.0 0.99 9.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESS68982.1 - 0.92 8.8 5.3 0.49 9.6 0.2 2.7 3 0 0 3 3 3 0 SHNi-TPR Neur_chan_memb PF02932.11 ESS68982.1 - 6.4 6.5 6.4 0.49 10.2 0.5 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_M14 PF00246.19 ESS68983.1 - 3.1e-27 95.9 0.0 7.4e-27 94.6 0.0 1.6 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 ESS68983.1 - 2.6e-05 23.2 0.0 4.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family V-SNARE_C PF12352.3 ESS68984.1 - 2.9e-07 30.4 3.6 2.9e-07 30.4 2.5 2.3 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus IpaD PF06511.6 ESS68984.1 - 0.038 12.9 0.5 0.067 12.1 0.3 1.3 1 1 0 1 1 1 0 Invasion plasmid antigen IpaD FlgN PF05130.7 ESS68984.1 - 0.048 13.9 4.3 0.13 12.5 2.9 1.7 1 1 0 1 1 1 0 FlgN protein TMF_DNA_bd PF12329.3 ESS68984.1 - 0.049 13.4 0.6 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Latarcin PF10279.4 ESS68984.1 - 0.053 13.7 2.7 0.082 13.1 0.1 2.3 2 1 0 2 2 2 0 Latarcin precursor V-SNARE PF05008.10 ESS68984.1 - 0.056 13.6 2.1 0.095 12.8 0.1 2.3 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Acyl-CoA_dh_C PF12806.2 ESS68984.1 - 0.21 11.4 2.3 0.49 10.2 0.5 2.1 2 0 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like Nsp1_C PF05064.8 ESS68984.1 - 0.8 9.3 2.8 20 4.8 0.1 2.7 3 0 0 3 3 3 0 Nsp1-like C-terminal region Proteasome PF00227.21 ESS68986.1 - 3.9e-25 88.2 0.6 1.4e-24 86.4 0.5 1.7 1 1 0 1 1 1 1 Proteasome subunit CDC73 PF05179.9 ESS68987.1 - 7.8e-26 91.0 0.0 9.2e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family Glycos_transf_1 PF00534.15 ESS68989.1 - 9.8e-14 51.1 0.0 1.5e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 ESS68989.1 - 3.9e-13 49.5 1.0 2.8e-12 46.6 0.7 2.4 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 ESS68989.1 - 1.5e-11 44.6 0.4 1.5e-11 44.6 0.3 2.9 4 0 0 4 4 4 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 ESS68989.1 - 1.1e-09 38.5 0.1 2.6e-09 37.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESS68989.1 - 6.5e-05 23.1 0.4 0.00016 21.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Acetyltransf_1 PF00583.19 ESS68989.1 - 0.067 13.2 0.0 0.3 11.1 0.0 2.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family MraY_sig1 PF10555.4 ESS68989.1 - 0.14 11.5 0.0 0.35 10.2 0.0 1.8 1 0 0 1 1 1 0 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 OmpH PF03938.9 ESS68990.1 - 0.00041 20.3 10.5 0.046 13.6 0.0 2.6 2 1 0 2 2 2 2 Outer membrane protein (OmpH-like) Fez1 PF06818.10 ESS68990.1 - 0.004 17.2 9.4 0.0075 16.3 6.5 1.4 1 0 0 1 1 1 1 Fez1 AAA_13 PF13166.1 ESS68990.1 - 0.0089 14.5 3.6 0.012 14.0 2.4 1.4 1 1 0 1 1 1 1 AAA domain DUF4168 PF13767.1 ESS68990.1 - 0.039 14.5 6.5 13 6.4 4.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4168) TPR_20 PF14561.1 ESS68990.1 - 0.068 13.2 4.9 0.13 12.4 0.2 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Baculo_PEP_C PF04513.7 ESS68990.1 - 0.074 12.8 2.3 2.9 7.7 0.1 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 ESS68990.1 - 0.091 12.8 3.2 0.22 11.6 2.2 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Kinesin-relat_1 PF12711.2 ESS68990.1 - 0.21 12.0 8.8 0.13 12.7 2.6 2.9 2 1 1 3 3 3 0 Kinesin motor Spc7 PF08317.6 ESS68990.1 - 0.27 9.8 9.6 0.15 10.6 5.0 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein ApoLp-III PF07464.6 ESS68990.1 - 0.41 10.6 9.9 2.9 7.8 4.0 2.3 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Cluap1 PF10234.4 ESS68990.1 - 0.52 9.4 9.3 2.5 7.2 2.6 2.5 1 1 1 2 2 2 0 Clusterin-associated protein-1 Bacillus_HBL PF05791.6 ESS68990.1 - 0.79 9.0 8.4 1.7 8.0 1.8 2.5 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) CDC37_N PF03234.9 ESS68990.1 - 1.2 9.4 7.8 2.2 8.5 5.4 1.5 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding APG6 PF04111.7 ESS68990.1 - 1.8 7.5 9.5 5.4 5.9 4.3 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.7 ESS68990.1 - 3.1 7.5 10.2 2.2 8.0 1.5 2.8 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 ESS68990.1 - 4 7.0 11.0 4.4 6.9 4.2 2.1 1 1 1 2 2 2 0 Mnd1 family Atg14 PF10186.4 ESS68990.1 - 4.5 6.1 9.7 25 3.6 6.6 2.0 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Kinetocho_Slk19 PF12709.2 ESS68990.1 - 7 6.8 13.6 82 3.3 0.0 4.7 4 1 1 5 5 5 0 Central kinetochore-associated IncA PF04156.9 ESS68990.1 - 7.6 6.0 11.7 14 5.2 0.1 2.2 1 1 1 2 2 2 0 IncA protein RVT_1 PF00078.22 ESS68991.1 - 0.0006 19.2 0.0 0.0026 17.1 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD PF12009.3 ESS68992.1 - 3.6e-14 52.8 0.1 5.9e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain DUF1712 PF08217.6 ESS68993.1 - 1.9e-05 23.1 0.0 2.6e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) ECH PF00378.15 ESS68994.1 - 5.5e-09 35.4 0.0 4.3e-08 32.5 0.0 2.1 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 ESS68994.1 - 3.5e-07 30.3 0.1 0.0013 18.8 0.0 4.1 4 0 0 4 4 4 1 2-enoyl-CoA Hydratase C-terminal region Macro PF01661.16 ESS68995.1 - 0.00014 21.7 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Macro domain PrgI PF12666.2 ESS68995.1 - 0.051 13.7 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 PrgI family protein LMBR1 PF04791.11 ESS68997.1 - 0.42 9.1 14.3 2.1 6.8 9.9 1.9 1 1 0 1 1 1 0 LMBR1-like membrane protein Actin PF00022.14 ESS68998.1 - 1.1e-94 317.0 0.0 1.2e-94 316.9 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESS68998.1 - 0.0026 16.4 0.0 0.082 11.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein TBCA PF02970.11 ESS68998.1 - 0.064 13.3 0.0 6.1 6.9 0.0 2.2 2 0 0 2 2 2 0 Tubulin binding cofactor A DUF4483 PF14825.1 ESS69000.1 - 0.019 14.6 0.3 5.3 6.6 0.0 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4483) DUF3595 PF12166.3 ESS69001.1 - 1.4e-75 254.7 0.0 1.6e-75 254.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3595) DUF3595 PF12166.3 ESS69002.1 - 4.5e-14 52.1 1.0 8.3e-14 51.2 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3595) Bromodomain PF00439.20 ESS69005.1 - 2.8e-15 55.9 0.0 5e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain BPL_LplA_LipB PF03099.14 ESS69006.1 - 1.4e-17 63.8 0.0 2.2e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family adh_short PF00106.20 ESS69007.1 - 5e-25 88.3 2.8 6e-25 88.0 0.5 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ESS69007.1 - 5e-11 42.6 0.6 1.4e-10 41.1 0.1 1.9 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 ESS69007.1 - 1.4e-06 28.3 0.0 1.9e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESS69007.1 - 6.1e-05 23.1 0.0 9.2e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 NADH(P)-binding Pyr_redox PF00070.22 ESS69007.1 - 0.00066 20.0 0.4 0.0013 19.1 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 ESS69007.1 - 0.0011 18.6 0.2 0.0016 18.1 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 ESS69007.1 - 0.0068 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 ESS69007.1 - 0.22 10.3 1.7 0.29 9.9 1.2 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Vps26 PF03643.10 ESS69009.1 - 8.1e-61 205.2 0.6 9.8e-61 204.9 0.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 ESS69009.1 - 1.1e-05 25.2 0.6 0.43 10.3 0.0 3.3 2 1 1 3 3 3 3 Arrestin (or S-antigen), N-terminal domain CRAL_TRIO PF00650.15 ESS69010.1 - 4.5e-26 91.2 0.0 6.2e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESS69010.1 - 0.0011 19.1 0.4 0.0011 19.1 0.3 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 ESS69010.1 - 0.034 14.0 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Snf7 PF03357.16 ESS69011.1 - 9e-27 93.5 23.9 9e-27 93.5 16.5 1.5 1 1 1 2 2 2 1 Snf7 FTR_C PF02741.10 ESS69011.1 - 0.1 12.3 1.3 0.16 11.7 0.3 1.6 1 1 1 2 2 2 0 FTR, proximal lobe Glyco_transf_25 PF01755.12 ESS69012.1 - 2.9e-18 66.2 0.0 1.5e-16 60.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF373 PF04123.8 ESS69012.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Transket_pyr PF02779.19 ESS69013.1 - 2e-58 196.8 0.0 2.9e-58 196.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESS69013.1 - 6.6e-47 159.6 0.0 1e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Mucin PF01456.12 ESS69014.1 - 4.4e-08 33.0 19.9 8.1e-06 25.6 13.8 2.3 1 1 0 1 1 1 1 Mucin-like glycoprotein Ndc1_Nup PF09531.5 ESS69014.1 - 7.9 4.7 11.2 12 4.2 7.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ORC6 PF05460.8 ESS69014.1 - 8.4 5.3 17.3 12 4.8 12.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2870 PF11069.3 ESS69015.1 - 3.3e-29 100.8 0.0 7.3e-29 99.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) Z1 PF10593.4 ESS69016.1 - 0.015 14.5 1.1 0.041 13.0 0.8 1.7 1 0 0 1 1 1 0 Z1 domain Nop53 PF07767.6 ESS69016.1 - 4 6.3 15.7 7.6 5.4 10.9 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TPR_11 PF13414.1 ESS69018.1 - 3.1e-12 45.9 3.5 2.1e-10 40.0 0.3 2.7 2 1 1 3 3 3 2 TPR repeat DUF3846 PF12957.2 ESS69018.1 - 6.7e-07 28.9 0.0 1.5e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3846) TPR_2 PF07719.12 ESS69018.1 - 4.7e-06 26.1 6.0 0.8 9.7 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS69018.1 - 6.3e-06 25.5 0.9 0.21 11.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS69018.1 - 0.0038 17.8 8.4 0.14 12.9 2.0 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS69018.1 - 0.0075 16.8 5.3 2.4 9.0 0.2 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESS69018.1 - 0.0099 15.6 1.4 7.9 6.5 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69018.1 - 0.16 12.3 2.6 0.41 11.0 0.9 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.12 ESS69018.1 - 1 9.6 8.7 0.066 13.5 1.9 2.1 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_12 PF13424.1 ESS69018.1 - 1.4 8.8 10.0 3 7.8 0.3 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat SQS_PSY PF00494.14 ESS69020.1 - 4.5e-12 45.8 0.1 7.6e-12 45.0 0.1 1.4 1 0 0 1 1 1 1 Squalene/phytoene synthase SRP54 PF00448.17 ESS69021.1 - 1.9e-55 187.3 0.1 3.9e-55 186.3 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.8 ESS69021.1 - 1.4e-08 34.4 0.6 1.6e-07 31.0 0.3 2.1 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal AAA_22 PF13401.1 ESS69021.1 - 3e-07 30.6 0.0 8.8e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESS69021.1 - 6.4e-06 25.4 0.0 1.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin ETF PF01012.16 ESS69021.1 - 3.6e-05 23.5 0.5 0.068 12.8 0.1 2.5 2 0 0 2 2 2 2 Electron transfer flavoprotein domain AAA_30 PF13604.1 ESS69021.1 - 0.00013 21.5 0.2 0.00031 20.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS69021.1 - 0.00069 19.3 0.2 0.043 13.5 0.0 2.7 1 1 1 2 2 2 1 Part of AAA domain CbiA PF01656.18 ESS69021.1 - 0.001 18.5 0.0 0.0099 15.3 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.10 ESS69021.1 - 0.0011 18.7 0.0 1.2 8.8 0.0 2.7 3 0 0 3 3 2 2 NTPase AAA_16 PF13191.1 ESS69021.1 - 0.0018 18.2 0.4 0.013 15.4 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain DAP3 PF10236.4 ESS69021.1 - 0.0045 15.9 0.0 0.0075 15.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.14 ESS69021.1 - 0.0048 16.3 0.0 0.013 14.9 0.0 1.7 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SRP54_N PF02881.14 ESS69021.1 - 0.0054 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_24 PF13479.1 ESS69021.1 - 0.0068 16.0 0.0 0.019 14.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain ArsA_ATPase PF02374.10 ESS69021.1 - 0.0087 15.1 0.1 0.15 11.0 0.0 2.2 2 0 0 2 2 2 1 Anion-transporting ATPase NACHT PF05729.7 ESS69021.1 - 0.01 15.5 0.0 0.53 9.9 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.1 ESS69021.1 - 0.013 15.3 0.0 0.039 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.15 ESS69021.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase MMR_HSR1 PF01926.18 ESS69021.1 - 0.018 15.0 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.9 ESS69021.1 - 0.025 14.3 0.1 0.31 10.7 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 ESS69021.1 - 0.029 14.2 0.0 0.079 12.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.22 ESS69021.1 - 0.032 14.5 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.2 ESS69021.1 - 0.035 13.5 0.1 0.081 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain DUF258 PF03193.11 ESS69021.1 - 0.066 12.3 0.0 0.41 9.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA PF00004.24 ESS69021.1 - 0.094 12.9 0.0 0.24 11.6 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ORC3_N PF07034.6 ESS69021.1 - 0.095 11.6 0.1 0.95 8.3 0.0 2.1 1 1 0 2 2 2 0 Origin recognition complex (ORC) subunit 3 N-terminus Thymidylate_kin PF02223.12 ESS69021.1 - 0.096 12.0 0.0 0.27 10.5 0.0 1.8 2 0 0 2 2 1 0 Thymidylate kinase AAA_29 PF13555.1 ESS69021.1 - 0.14 11.7 0.0 0.37 10.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.15 ESS69021.1 - 0.15 10.7 0.0 0.2 10.2 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit UvrD-helicase PF00580.16 ESS69021.1 - 0.26 10.5 0.7 1.2 8.3 0.5 2.1 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain DUF2009 PF09418.5 ESS69022.1 - 2.7e-116 389.0 0.0 1.2e-115 386.9 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2009) PALP PF00291.20 ESS69023.1 - 3.7e-57 193.8 4.0 4.3e-57 193.6 2.8 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme WD40 PF00400.27 ESS69025.1 - 4.5e-16 58.0 3.4 0.00045 20.0 0.1 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat DUF1619 PF07773.6 ESS69026.1 - 3.6e-81 273.2 1.9 2.5e-78 263.8 2.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) Laminin_G_3 PF13385.1 ESS69027.1 - 3e-17 63.3 0.1 7.3e-17 62.0 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS69027.1 - 3e-11 42.9 13.1 5.3e-11 42.1 9.1 1.4 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Pkinase PF00069.20 ESS69042.1 - 3e-71 239.6 0.0 4.2e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69042.1 - 9.9e-37 126.4 0.0 1.4e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69042.1 - 1.5e-09 37.2 0.0 2.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 ESS69042.1 - 0.0066 15.3 0.9 0.017 13.9 0.7 1.5 1 1 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 ESS69042.1 - 0.057 12.4 0.3 0.11 11.5 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS69042.1 - 0.17 11.6 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family UPF0227 PF05728.7 ESS69043.1 - 0.15 11.7 0.6 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) IncA PF04156.9 ESS69043.1 - 0.25 10.9 0.8 20 4.7 0.1 2.4 2 0 0 2 2 2 0 IncA protein DUF3808 PF10300.4 ESS69044.1 - 2.8e-24 85.5 1.6 7.1e-24 84.2 1.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_12 PF13424.1 ESS69044.1 - 6.5e-09 35.5 9.3 0.002 17.9 0.2 4.7 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS69044.1 - 8.3e-06 26.3 9.0 0.14 12.8 0.2 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF2225 PF09986.4 ESS69044.1 - 0.00055 19.4 0.2 0.086 12.2 0.0 2.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_2 PF07719.12 ESS69044.1 - 0.0015 18.3 8.1 0.0082 15.9 0.6 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS69044.1 - 0.004 16.7 13.2 0.0048 16.5 0.7 4.2 5 0 0 5 5 5 2 TPR repeat TPR_8 PF13181.1 ESS69044.1 - 0.0056 16.3 0.5 0.06 13.1 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS69044.1 - 0.011 16.3 3.7 6 7.8 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69044.1 - 0.02 15.1 7.8 0.35 11.2 0.1 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS69044.1 - 0.079 12.6 4.8 0.9 9.2 0.7 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS69044.1 - 0.12 12.9 14.7 0.42 11.1 0.9 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat LRR_4 PF12799.2 ESS69046.1 - 1.1e-15 56.7 14.1 8.3e-08 31.6 0.8 3.5 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS69046.1 - 2.8e-12 46.2 12.8 2.1e-07 30.5 4.6 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.1 ESS69046.1 - 9.9e-09 34.9 3.5 2e-08 34.0 1.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 ESS69046.1 - 5e-07 28.8 12.1 0.15 12.1 0.0 5.9 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS69046.1 - 8.8e-05 22.0 9.3 7.9 7.1 0.1 5.9 4 1 1 5 5 5 2 Leucine rich repeat LRR_6 PF13516.1 ESS69046.1 - 0.00018 21.2 15.5 0.024 14.6 0.1 4.8 2 1 2 4 4 4 2 Leucine Rich repeat Kinase-PPPase PF03618.9 ESS69046.1 - 0.093 12.2 0.0 0.093 12.2 0.0 3.0 3 1 0 3 3 3 0 Kinase/pyrophosphorylase Fib_alpha PF08702.5 ESS69046.1 - 0.54 10.3 10.9 0.14 12.3 0.8 3.1 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Cyclin PF08613.6 ESS69047.1 - 6.3e-18 65.6 0.1 8.7e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESS69047.1 - 3.5e-06 26.6 0.3 5.8e-06 25.8 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF773 PF05600.7 ESS69049.1 - 5.4e-12 45.2 9.0 4.7e-07 28.9 6.3 3.2 1 1 0 1 1 1 1 Protein of unknown function (DUF773) p25-alpha PF05517.7 ESS69049.1 - 0.0045 17.2 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 p25-alpha Myosin_tail_1 PF01576.14 ESS69049.1 - 0.031 12.0 8.1 0.051 11.2 2.2 2.1 2 0 0 2 2 2 0 Myosin tail DUF3227 PF11537.3 ESS69049.1 - 0.089 12.9 0.0 2.4 8.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3227) GYD PF08734.6 ESS69049.1 - 0.092 12.4 0.0 5.2 6.8 0.0 2.9 2 0 0 2 2 2 0 GYD domain Pkinase PF00069.20 ESS69050.1 - 4.2e-40 137.5 0.0 4.9e-19 68.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69050.1 - 1.4e-09 37.4 0.0 8.7e-06 24.9 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase zf-CCCH PF00642.19 ESS69051.1 - 0.00022 20.8 1.0 0.00038 20.0 0.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Med11 PF10280.4 ESS69051.1 - 0.044 13.8 1.8 0.072 13.1 1.3 1.4 1 0 0 1 1 1 0 Mediator complex protein IncA PF04156.9 ESS69051.1 - 0.92 9.0 5.7 1.4 8.5 3.9 1.3 1 0 0 1 1 1 0 IncA protein p450 PF00067.17 ESS69052.1 - 5.6e-48 163.5 0.0 7e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RF-1 PF00472.15 ESS69053.1 - 6.6e-12 45.2 0.5 6.6e-12 45.2 0.4 2.0 3 0 0 3 3 3 1 RF-1 domain Rhodanese PF00581.15 ESS69054.1 - 0.00093 19.5 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain S-AdoMet_synt_C PF02773.11 ESS69055.1 - 4e-70 233.9 0.2 6.1e-70 233.3 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 ESS69055.1 - 2.3e-46 156.6 0.0 2.8e-45 153.1 0.0 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 ESS69055.1 - 9.3e-39 131.6 0.0 1.6e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Strep_pep PF14404.1 ESS69055.1 - 0.08 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species PDZ PF00595.19 ESS69056.1 - 0.0002 21.4 0.0 0.00032 20.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 ESS69056.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain zf-MIZ PF02891.15 ESS69057.1 - 1.1e-17 63.3 6.2 1.8e-17 62.5 4.3 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PWWP PF00855.12 ESS69057.1 - 3.9e-05 23.7 0.0 7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 PWWP domain zf-Nse PF11789.3 ESS69057.1 - 0.0014 18.0 0.9 0.0028 17.1 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit RNA_pol_L PF01193.19 ESS69057.1 - 0.16 11.0 0.0 0.3 10.2 0.0 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Pkinase PF00069.20 ESS69059.1 - 1e-28 100.2 0.0 1.3e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69059.1 - 6e-11 41.8 0.0 6.8e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESS69059.1 - 0.0064 15.5 0.0 0.017 14.1 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.11 ESS69059.1 - 0.029 14.3 0.0 0.14 12.1 0.0 2.0 1 1 1 2 2 2 0 ABC1 family DUF4605 PF15378.1 ESS69059.1 - 0.18 11.5 0.0 0.18 11.5 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4605) TPR_11 PF13414.1 ESS69060.1 - 0.087 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 TPR repeat TPR_11 PF13414.1 ESS69061.1 - 2.1e-09 36.8 1.9 0.0015 18.0 0.1 3.1 2 1 1 3 3 3 3 TPR repeat TPR_17 PF13431.1 ESS69061.1 - 1.3e-06 28.1 0.2 2.2 8.7 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS69061.1 - 0.00017 21.8 4.1 2.7 8.8 0.2 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS69061.1 - 0.0024 18.4 1.4 0.86 10.3 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS69061.1 - 0.0026 17.5 4.6 0.03 14.1 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69061.1 - 0.047 14.0 0.8 1.3 9.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESS69061.1 - 0.08 12.9 2.6 2.1 8.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DNA_ligase_A_M PF01068.16 ESS69062.1 - 4.4e-56 189.4 0.1 1.1e-55 188.2 0.0 1.6 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 ESS69062.1 - 2.6e-40 138.1 0.1 5.2e-40 137.1 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 ESS69062.1 - 6e-25 87.4 0.0 1.5e-24 86.2 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 ESS69062.1 - 0.0042 16.7 0.7 1.3 8.7 0.0 2.5 2 0 0 2 2 2 2 DNA ligase OB-like domain DUF1412 PF07203.6 ESS69062.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1412) MKT1_C PF12246.3 ESS69063.1 - 1.9e-58 197.3 0.0 2.9e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 ESS69063.1 - 5e-21 74.8 0.0 1.5e-20 73.2 0.0 1.9 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.12 ESS69063.1 - 0.081 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 XPG N-terminal domain XPG_I PF00867.13 ESS69063.1 - 0.097 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 XPG I-region Lectin_N PF03954.9 ESS69064.1 - 0.13 11.6 0.4 0.23 10.8 0.3 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF1230 PF06799.6 ESS69064.1 - 1.7 8.4 5.3 0.48 10.2 1.6 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1230) Tcp11 PF05794.8 ESS69065.1 - 9.7e-20 70.6 0.4 4.9e-19 68.3 0.1 2.2 2 1 0 2 2 2 1 T-complex protein 11 Caldesmon PF02029.10 ESS69065.1 - 0.00047 18.6 3.5 0.00052 18.5 2.4 1.1 1 0 0 1 1 1 1 Caldesmon CrtC PF07143.6 ESS69065.1 - 0.13 11.5 0.6 1.3 8.2 0.0 2.5 3 0 0 3 3 3 0 Hydroxyneurosporene synthase (CrtC) UBN_AB PF14075.1 ESS69065.1 - 0.53 9.9 5.6 0.35 10.5 2.1 2.1 2 0 0 2 2 2 0 Ubinuclein conserved middle domain WD40 PF00400.27 ESS69066.1 - 1.3e-07 31.2 8.6 0.26 11.2 0.1 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Dynein_heavy PF03028.10 ESS69066.1 - 0.00067 17.8 0.0 0.00093 17.3 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF3639 PF12341.3 ESS69066.1 - 0.38 10.7 4.2 2.5 8.1 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3639) CAS_CSE1 PF03378.10 ESS69067.1 - 3.6e-86 289.1 1.7 2.5e-85 286.4 0.0 2.6 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus Cse1 PF08506.5 ESS69067.1 - 1e-60 205.2 0.0 1.5e-60 204.7 0.0 1.3 1 0 0 1 1 1 1 Cse1 HEAT_2 PF13646.1 ESS69067.1 - 0.00013 22.1 1.1 0.7 10.2 0.1 3.7 4 0 0 4 4 4 2 HEAT repeats IBN_N PF03810.14 ESS69067.1 - 0.00056 19.7 0.0 0.0021 17.9 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.7 ESS69067.1 - 0.014 15.3 0.9 0.57 10.0 0.0 3.5 3 1 1 4 4 4 0 Exportin 1-like protein Adaptin_N PF01602.15 ESS69067.1 - 0.016 13.5 0.6 0.21 9.8 0.0 2.6 3 0 0 3 3 3 0 Adaptin N terminal region HEAT_EZ PF13513.1 ESS69067.1 - 0.068 13.6 0.3 1 9.9 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat PGK PF00162.14 ESS69068.1 - 2.4e-132 441.1 0.0 2.9e-132 440.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase PAS PF00989.19 ESS69068.1 - 8.1e-07 28.8 0.0 2.1e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 ESS69068.1 - 1.4e-05 25.4 0.0 5.7e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.1 ESS69068.1 - 9.3e-05 22.1 0.0 0.00049 19.8 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.5 ESS69068.1 - 0.00012 22.0 0.0 0.00035 20.5 0.0 1.8 1 0 0 1 1 1 1 PAS fold EF-hand_1 PF00036.27 ESS69069.1 - 1.7e-28 95.6 14.3 4.1e-05 22.5 0.1 8.9 9 0 0 9 9 9 5 EF hand EF-hand_7 PF13499.1 ESS69069.1 - 3.6e-27 94.2 22.6 1.8e-08 34.3 1.1 6.2 6 1 0 6 6 6 3 EF-hand domain pair EF-hand_6 PF13405.1 ESS69069.1 - 5.2e-22 75.6 17.2 0.00014 21.4 0.1 9.1 9 0 0 9 9 9 6 EF-hand domain EF-hand_8 PF13833.1 ESS69069.1 - 5.6e-20 70.7 9.7 0.007 15.9 0.0 8.8 8 1 1 9 9 9 6 EF-hand domain pair EF-hand_5 PF13202.1 ESS69069.1 - 1.3e-19 68.5 8.5 2.4e-05 23.4 0.2 6.0 5 0 0 5 5 5 5 EF hand SPARC_Ca_bdg PF10591.4 ESS69069.1 - 4.3e-07 29.9 3.7 0.76 9.8 0.1 4.8 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region BAR PF03114.13 ESS69072.1 - 0.017 14.6 4.6 0.034 13.6 3.2 1.5 1 1 0 1 1 1 0 BAR domain PAT1 PF09770.4 ESS69072.1 - 9.2 4.3 23.3 13 3.8 16.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MORN PF02493.15 ESS69073.1 - 4.6e-67 217.9 72.8 1.1e-09 37.4 1.7 11.1 11 0 0 11 11 11 11 MORN repeat AA_permease_2 PF13520.1 ESS69074.1 - 1.9e-33 115.6 31.2 2.5e-33 115.2 21.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESS69074.1 - 3.3e-21 75.1 26.6 4.3e-21 74.8 18.5 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.1 ESS69074.1 - 5.4e-08 32.5 9.9 5.4e-08 32.5 6.9 2.6 2 0 0 2 2 2 1 C-terminus of AA_permease XPC-binding PF09280.6 ESS69075.1 - 4.2e-19 67.7 1.6 8.1e-19 66.8 1.1 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.26 ESS69075.1 - 4.4e-14 51.8 1.3 3e-06 26.8 0.0 2.8 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.18 ESS69075.1 - 1.1e-05 24.7 0.0 2.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA_3 PF09288.5 ESS69075.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain TPR_12 PF13424.1 ESS69077.1 - 0.094 12.6 0.2 2.3 8.2 0.1 2.4 1 1 0 1 1 1 0 Tetratricopeptide repeat Metallophos PF00149.23 ESS69078.1 - 8.6e-11 41.5 0.1 1.7e-10 40.6 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Ank_2 PF12796.2 ESS69079.1 - 5e-39 132.5 0.7 2.5e-15 56.5 0.0 4.0 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESS69079.1 - 2.3e-38 128.1 0.3 1.1e-07 31.3 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 ESS69079.1 - 6e-32 109.4 1.0 9.7e-10 38.7 0.0 5.8 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESS69079.1 - 4.7e-28 96.5 5.4 1.8e-06 28.0 0.0 6.4 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS69079.1 - 6.3e-28 94.0 1.0 0.00075 19.5 0.0 7.1 7 0 0 7 7 7 6 Ankyrin repeat Helicase_C PF00271.26 ESS69080.1 - 4.3e-13 48.9 0.0 1.2e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 ESS69080.1 - 7.1e-10 38.8 0.0 2e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESS69080.1 - 1.2e-05 25.1 0.0 3.2e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 ESS69080.1 - 0.0087 15.5 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase APC8 PF04049.8 ESS69081.1 - 0.075 12.7 5.7 0.13 12.0 4.0 1.4 1 1 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 DUF1779 PF08680.5 ESS69081.1 - 0.11 12.2 3.7 0.14 12.0 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1779) DUF1423 PF07227.6 ESS69081.1 - 0.73 8.4 10.6 0.87 8.1 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) APG6 PF04111.7 ESS69081.1 - 0.81 8.6 10.5 0.97 8.4 7.3 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4288 PF14119.1 ESS69081.1 - 2 8.5 7.3 4.2 7.5 5.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4288) tRNA-synt_1c PF00749.16 ESS69082.1 - 1.7e-99 332.4 0.0 2.4e-99 331.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 ESS69082.1 - 4.5e-36 124.1 0.6 7.3e-36 123.4 0.4 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain FKBP_C PF00254.23 ESS69084.1 - 0.062 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase HMG-CoA_red PF00368.13 ESS69085.1 - 1.1e-156 521.1 1.1 1.3e-156 520.9 0.8 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase AA_permease_2 PF13520.1 ESS69086.1 - 7.6e-25 87.3 13.9 9.2e-25 87.0 9.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESS69086.1 - 1.8e-06 26.6 9.1 2.3e-06 26.2 6.3 1.1 1 0 0 1 1 1 1 Amino acid permease HemY_N PF07219.8 ESS69086.1 - 0.2 11.2 1.5 0.87 9.1 0.1 2.3 2 0 0 2 2 2 0 HemY protein N-terminus zf-LITAF-like PF10601.4 ESS69087.1 - 0.13 12.1 0.2 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain DivIC PF04977.10 ESS69087.1 - 1.8 8.1 4.9 3.6 7.1 0.0 3.1 3 0 0 3 3 3 0 Septum formation initiator Atg14 PF10186.4 ESS69087.1 - 8 5.2 8.1 2.2 7.1 1.3 2.3 2 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Trichoplein PF13868.1 ESS69088.1 - 6.1e-17 61.0 55.2 7.4e-17 60.7 38.2 1.0 1 0 0 1 1 1 1 Tumour suppressor, Mitostatin Ank_3 PF13606.1 ESS69089.1 - 0.094 13.0 0.2 1.7 9.1 0.0 3.2 4 0 0 4 4 4 0 Ankyrin repeat SAM_decarbox PF01536.11 ESS69090.1 - 2e-17 62.8 0.0 1.3e-11 43.7 0.0 2.2 2 0 0 2 2 2 2 Adenosylmethionine decarboxylase SAM_decarbox PF01536.11 ESS69091.1 - 1.3e-114 382.3 0.0 1.5e-114 382.1 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase RRM_1 PF00076.17 ESS69093.1 - 0.0041 16.7 0.0 0.0073 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69093.1 - 0.05 13.5 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) GHMP_kinases_C PF08544.8 ESS69094.1 - 3e-13 49.7 0.1 6.2e-13 48.7 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESS69094.1 - 9.2e-13 48.0 0.8 1.8e-12 47.1 0.1 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain Birna_VP5 PF03042.9 ESS69095.1 - 0.13 11.7 9.6 0.11 12.0 0.7 2.9 2 1 0 2 2 2 0 Birnavirus VP5 protein Kinesin PF00225.18 ESS69096.1 - 1.6e-79 267.0 0.0 1.6e-79 267.0 0.0 2.0 3 0 0 3 3 3 1 Kinesin motor domain Reo_sigmaC PF04582.7 ESS69096.1 - 0.13 11.3 2.8 0.16 11.1 0.1 2.5 3 0 0 3 3 3 0 Reovirus sigma C capsid protein AAA_22 PF13401.1 ESS69096.1 - 1.2 9.2 0.0 1.2 9.2 0.0 4.0 3 1 1 4 4 4 0 AAA domain Pkinase PF00069.20 ESS69097.1 - 3.8e-69 232.7 0.0 5.5e-69 232.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69097.1 - 4.4e-46 157.0 0.0 6.9e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69097.1 - 0.0081 15.1 0.0 0.017 14.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like ABC1 PF03109.11 ESS69097.1 - 0.023 14.6 0.0 0.067 13.1 0.0 1.7 1 0 0 1 1 1 0 ABC1 family V-SNARE PF05008.10 ESS69097.1 - 0.12 12.5 2.9 0.23 11.6 2.0 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus GNT-I PF03071.10 ESS69097.1 - 0.39 9.2 0.3 0.57 8.6 0.2 1.2 1 0 0 1 1 1 0 GNT-I family DUF544 PF04424.8 ESS69098.1 - 4.5e-10 39.3 0.0 2.7e-09 36.8 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF544) eIF-3_zeta PF05091.7 ESS69100.1 - 6.6e-119 397.8 0.7 9.8e-118 394.0 0.5 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF21 PF01595.15 ESS69101.1 - 5.1e-25 87.8 7.8 5.2e-25 87.8 4.7 1.5 2 0 0 2 2 2 1 Domain of unknown function DUF21 CBS PF00571.23 ESS69101.1 - 0.00016 21.3 0.1 0.15 11.8 0.0 3.9 5 0 0 5 5 5 2 CBS domain PalH PF08733.5 ESS69101.1 - 0.26 10.0 0.0 0.26 10.0 0.0 2.1 2 0 0 2 2 2 0 PalH/RIM21 TPR_11 PF13414.1 ESS69102.1 - 5.5e-104 339.8 55.9 8.7e-17 60.5 0.5 9.0 5 2 5 10 10 10 10 TPR repeat TPR_1 PF00515.23 ESS69102.1 - 1.6e-82 267.9 40.6 1.3e-08 34.0 0.0 14.8 14 1 0 14 14 14 13 Tetratricopeptide repeat TPR_2 PF07719.12 ESS69102.1 - 1.2e-68 221.6 45.8 4e-07 29.4 0.7 15.0 15 1 0 15 15 15 13 Tetratricopeptide repeat TPR_17 PF13431.1 ESS69102.1 - 4.8e-52 169.8 35.2 3.3e-05 23.7 0.0 13.6 14 0 0 14 14 13 11 Tetratricopeptide repeat TPR_16 PF13432.1 ESS69102.1 - 2.7e-38 129.8 37.0 6.2e-06 26.7 2.9 10.0 5 2 4 10 10 10 8 Tetratricopeptide repeat TPR_9 PF13371.1 ESS69102.1 - 7.6e-37 125.0 22.6 4.6e-07 29.5 0.0 11.0 4 3 6 11 11 11 10 Tetratricopeptide repeat TPR_12 PF13424.1 ESS69102.1 - 7.5e-35 118.7 39.0 2.8e-07 30.3 0.2 9.5 3 2 5 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.1 ESS69102.1 - 3.7e-29 98.2 32.8 0.0057 16.3 0.2 13.2 13 2 2 15 15 12 8 Tetratricopeptide repeat TPR_14 PF13428.1 ESS69102.1 - 1.8e-21 74.6 28.4 0.0014 19.0 0.1 12.4 5 3 9 14 14 14 6 Tetratricopeptide repeat TPR_6 PF13174.1 ESS69102.1 - 5.3e-21 73.5 24.6 0.011 16.2 0.0 12.8 13 0 0 13 13 13 5 Tetratricopeptide repeat Apc3 PF12895.2 ESS69102.1 - 1.2e-18 67.0 18.7 4.4e-05 23.5 1.3 7.0 4 3 4 8 8 8 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESS69102.1 - 1.4e-17 63.8 20.4 0.0044 17.3 0.4 9.4 6 3 4 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESS69102.1 - 1.7e-14 52.3 34.9 0.91 9.4 0.0 13.6 11 3 3 14 14 14 4 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESS69102.1 - 1.3e-10 40.3 20.1 0.14 11.4 0.0 10.1 11 0 0 11 11 11 3 SHNi-TPR TPR_15 PF13429.1 ESS69102.1 - 4.1e-07 29.3 8.5 0.031 13.3 0.0 7.0 4 2 3 8 8 8 1 Tetratricopeptide repeat NARP1 PF12569.3 ESS69102.1 - 5e-05 22.2 17.7 0.01 14.6 0.1 6.1 4 2 2 7 7 7 2 NMDA receptor-regulated protein 1 BTAD PF03704.12 ESS69102.1 - 0.00047 20.4 4.6 3.7 7.8 0.0 5.5 3 1 2 5 5 5 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.1 ESS69102.1 - 0.00097 18.9 8.6 3.3 7.6 0.1 6.6 6 2 2 8 8 6 1 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.9 ESS69102.1 - 0.002 18.3 1.7 64 4.4 0.0 6.1 6 0 0 6 6 4 0 Tetratricopeptide repeat FAT PF02259.18 ESS69102.1 - 0.045 12.7 0.3 1.4 7.8 0.0 3.1 2 1 1 3 3 3 0 FAT domain TPR_5 PF12688.2 ESS69102.1 - 0.093 12.7 16.2 32 4.5 3.0 7.0 5 2 1 6 6 6 0 Tetratrico peptide repeat TPR_20 PF14561.1 ESS69102.1 - 1.1 9.4 19.2 0.89 9.7 0.1 6.2 6 2 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.13 ESS69102.1 - 7 6.6 35.6 8.8 6.2 0.2 9.5 8 2 1 9 9 9 0 MIT (microtubule interacting and transport) domain DUF2817 PF10994.3 ESS69103.1 - 1e-51 176.0 0.2 1.3e-51 175.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) RhoGEF PF00621.15 ESS69104.1 - 1.6e-07 31.4 0.0 9.9e-07 28.7 0.0 2.3 2 1 0 2 2 2 1 RhoGEF domain Gp_dh_C PF02800.15 ESS69105.1 - 3.2e-65 218.3 0.1 5.4e-65 217.6 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESS69105.1 - 5.5e-54 182.2 0.1 9.1e-54 181.5 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DUF812 PF05667.6 ESS69106.1 - 0.24 9.8 20.2 0.4 9.1 14.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Mgr1 PF08602.5 ESS69106.1 - 0.64 8.9 7.5 0.3 10.0 3.6 1.5 1 1 1 2 2 2 0 Mgr1-like, i-AAA protease complex subunit Pkinase PF00069.20 ESS69107.1 - 2.7e-49 167.6 0.0 3.6e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69107.1 - 1.2e-15 57.2 0.0 1.6e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS69107.1 - 3e-06 27.1 0.2 4.5e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS69107.1 - 3e-05 23.1 0.0 8.2e-05 21.7 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESS69107.1 - 0.0084 15.1 0.0 0.016 14.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESS69107.1 - 0.058 12.7 0.0 0.19 11.0 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Aldedh PF00171.17 ESS69108.1 - 1.5e-118 396.0 0.0 2e-118 395.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ESS69108.1 - 0.00013 21.3 0.1 0.00038 19.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) PPR PF01535.15 ESS69110.1 - 2.5e-06 27.0 2.4 0.79 9.8 0.0 5.9 6 0 0 6 6 6 2 PPR repeat PPR_2 PF13041.1 ESS69110.1 - 1.6e-05 24.8 0.1 0.45 10.5 0.0 5.4 7 0 0 7 7 7 1 PPR repeat family Apc3 PF12895.2 ESS69110.1 - 0.00036 20.6 0.0 3.4 7.8 0.0 4.6 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS69110.1 - 0.0089 16.5 10.1 19 6.2 0.1 6.7 5 2 4 9 9 9 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69110.1 - 0.016 15.5 0.2 3.6 7.9 0.0 3.8 2 2 2 4 4 4 0 Tetratricopeptide repeat PPR_3 PF13812.1 ESS69110.1 - 0.032 14.5 16.6 0.71 10.3 0.0 7.5 9 0 0 9 9 9 0 Pentatricopeptide repeat domain FUN14 PF04930.10 ESS69113.1 - 0.0018 18.5 0.0 0.0031 17.7 0.0 1.4 1 1 0 1 1 1 1 FUN14 family Myosin_head PF00063.16 ESS69114.1 - 4.3e-09 35.0 0.1 4.3e-09 35.0 0.1 2.3 2 0 0 2 2 2 1 Myosin head (motor domain) RabGAP-TBC PF00566.13 ESS69115.1 - 4e-35 121.2 0.1 5.2e-35 120.8 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain R3H PF01424.17 ESS69115.1 - 0.13 11.9 0.0 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 R3H domain Mt_ATP-synt_D PF05873.7 ESS69117.1 - 0.33 10.5 13.3 0.18 11.4 3.9 2.7 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) RNA_lig_T4_1 PF09511.5 ESS69117.1 - 0.65 9.4 8.0 0.97 8.8 5.6 1.2 1 0 0 1 1 1 0 RNA ligase CRT10 PF08728.5 ESS69117.1 - 3.6 5.4 7.1 4.1 5.2 5.0 1.2 1 0 0 1 1 1 0 CRT10 Cpn60_TCP1 PF00118.19 ESS69118.1 - 1.8e-107 359.9 2.3 2e-107 359.8 1.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-CCCH PF00642.19 ESS69119.1 - 2.3e-05 23.9 2.9 4.6e-05 22.9 2.0 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS69119.1 - 0.044 13.7 2.5 0.092 12.7 1.7 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type PocR PF10114.4 ESS69120.1 - 0.016 14.4 0.1 0.025 13.7 0.1 1.2 1 0 0 1 1 1 0 Sensory domain found in PocR Sod_Fe_C PF02777.13 ESS69121.1 - 1.1e-07 31.6 0.0 2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 ESS69121.1 - 0.0002 21.5 0.5 0.00032 20.8 0.0 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF2270 PF10028.4 ESS69122.1 - 0.08 12.4 0.9 0.13 11.7 0.6 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) TPR_1 PF00515.23 ESS69123.1 - 2.4e-24 83.8 3.0 7.8e-07 28.4 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESS69123.1 - 8.9e-24 82.9 6.0 6.7e-18 64.1 0.3 2.6 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESS69123.1 - 5e-18 63.4 7.8 1.8e-06 27.3 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS69123.1 - 4e-10 39.0 0.8 0.00034 20.5 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS69123.1 - 2.4e-09 37.6 0.3 1.2e-05 25.8 0.0 2.6 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS69123.1 - 3.3e-08 33.3 3.3 1.1e-05 25.2 0.4 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS69123.1 - 1.3e-07 31.6 0.1 0.088 13.4 0.1 3.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69123.1 - 3.4e-07 30.4 1.0 0.0088 16.3 0.0 3.1 1 1 0 2 2 2 2 Tetratricopeptide repeat Ins_allergen_rp PF06757.8 ESS69123.1 - 1.5e-06 27.8 2.0 0.025 14.0 0.1 3.5 3 0 0 3 3 3 1 Insect allergen related repeat, nitrile-specifier detoxification TPR_8 PF13181.1 ESS69123.1 - 1.8e-06 27.2 7.3 0.17 11.7 0.4 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS69123.1 - 4.2e-06 26.1 1.0 0.95 9.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat SGT1 PF07093.6 ESS69123.1 - 1.8e-05 23.3 1.4 3.2e-05 22.5 1.0 1.3 1 0 0 1 1 1 1 SGT1 protein Apc3 PF12895.2 ESS69123.1 - 0.0001 22.3 12.4 0.0018 18.3 0.6 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 ESS69123.1 - 0.0069 16.2 0.3 2.6 7.9 0.0 2.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 ESS69123.1 - 0.0082 15.9 0.1 0.091 12.6 0.0 2.2 1 1 2 3 3 3 2 Tetratricopeptide repeat DUF2098 PF09871.4 ESS69123.1 - 0.013 15.3 0.3 0.044 13.7 0.0 2.0 2 0 0 2 2 1 0 Uncharacterized protein conserved in archaea (DUF2098) TPR_6 PF13174.1 ESS69123.1 - 0.027 14.8 1.9 1.8 9.1 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESS69123.1 - 0.082 12.8 1.8 3.2 7.6 0.1 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain SPA PF08616.5 ESS69124.1 - 2.6e-30 104.4 0.0 4.7e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.7 ESS69124.1 - 5.9e-10 39.3 0.0 2.5e-06 27.5 0.0 2.3 2 0 0 2 2 2 2 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2347 PF09804.4 ESS69124.1 - 0.00059 19.2 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) GRAM PF02893.15 ESS69125.1 - 9.7e-10 37.8 0.0 3.2e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 GRAM domain Erythro_esteras PF05139.9 ESS69125.1 - 0.041 13.0 0.7 0.086 12.0 0.5 1.4 1 0 0 1 1 1 0 Erythromycin esterase Archease PF01951.11 ESS69125.1 - 0.053 13.4 0.2 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) TPR_MLP1_2 PF07926.7 ESS69126.1 - 0.024 14.3 6.4 0.046 13.4 4.5 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Endotoxin_M PF00555.14 ESS69126.1 - 0.047 13.5 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 delta endotoxin DUF641 PF04859.7 ESS69126.1 - 0.048 13.4 5.0 0.1 12.3 3.5 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Phage_lysis PF03245.8 ESS69126.1 - 0.063 13.2 1.1 0.14 12.2 0.7 1.5 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein DUF2984 PF11203.3 ESS69126.1 - 0.11 12.5 0.5 0.22 11.6 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2984) Phage_GP20 PF06810.6 ESS69126.1 - 0.13 11.6 6.3 0.35 10.3 4.4 1.6 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF2968 PF11180.3 ESS69126.1 - 0.7 9.2 10.0 0.11 11.9 3.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Bap31 PF05529.7 ESS69126.1 - 3.7 6.9 5.6 7.1 6.0 3.9 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like LRR_4 PF12799.2 ESS69127.1 - 6.9e-06 25.5 1.3 0.0056 16.2 0.3 3.1 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS69127.1 - 0.00032 20.3 0.6 1.4 9.2 0.0 4.0 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS69127.1 - 0.00046 19.9 5.9 0.56 10.4 0.0 4.8 4 1 0 4 4 4 2 Leucine Rich repeat LRR_8 PF13855.1 ESS69127.1 - 0.097 12.4 4.3 0.65 9.7 0.3 3.1 2 1 2 4 4 4 0 Leucine rich repeat Adipogenin PF15202.1 ESS69127.1 - 0.21 11.4 0.9 0.39 10.6 0.6 1.4 1 0 0 1 1 1 0 Adipogenin LRR_7 PF13504.1 ESS69127.1 - 0.29 11.4 3.0 36 5.1 0.0 4.1 4 0 0 4 4 4 0 Leucine rich repeat SH3_9 PF14604.1 ESS69128.1 - 9.7e-07 28.2 0.0 1.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESS69128.1 - 1.4e-06 27.7 0.3 2.7e-06 26.7 0.1 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 ESS69128.1 - 5e-06 25.7 0.0 9.5e-06 24.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Filament PF00038.16 ESS69128.1 - 0.0006 19.3 4.2 0.00093 18.7 2.9 1.2 1 0 0 1 1 1 1 Intermediate filament protein DUF4201 PF13870.1 ESS69128.1 - 0.022 14.2 5.4 0.034 13.5 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF1319 PF07028.6 ESS69128.1 - 0.05 13.8 1.1 0.083 13.0 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) DUF972 PF06156.8 ESS69128.1 - 0.15 12.3 1.6 0.34 11.2 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Atg14 PF10186.4 ESS69128.1 - 0.4 9.5 5.0 0.67 8.8 3.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TPT PF03151.11 ESS69129.1 - 4e-18 65.5 14.6 4e-18 65.5 10.1 2.7 2 1 1 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 ESS69129.1 - 0.015 15.3 15.4 0.015 15.3 10.6 2.4 2 0 0 2 2 2 0 EamA-like transporter family EmrE PF13536.1 ESS69129.1 - 0.036 14.2 25.4 0.09 12.9 6.6 3.3 2 1 0 2 2 2 0 Multidrug resistance efflux transporter SAM_2 PF07647.12 ESS69130.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESS69130.1 - 0.068 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ATG27 PF09451.5 ESS69131.1 - 3.1e-05 23.3 0.0 4.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 TPR_12 PF13424.1 ESS69132.1 - 7.9e-06 25.7 1.1 0.00057 19.7 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS69132.1 - 5.2 7.2 5.9 10 6.3 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CLASP_N PF12348.3 ESS69133.1 - 2e-05 24.0 0.1 3.9e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 CLASP N terminal AAA PF00004.24 ESS69134.1 - 8e-14 51.9 0.0 1.5e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 ESS69134.1 - 3.7e-12 46.0 0.0 1.3e-11 44.2 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESS69134.1 - 5.8e-10 39.0 0.0 9.2e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.1 ESS69134.1 - 8.5e-09 35.6 0.9 4e-05 23.6 0.0 3.2 1 1 1 3 3 3 1 AAA ATPase domain Rad17 PF03215.10 ESS69134.1 - 1.4e-07 30.6 0.0 0.00022 20.0 0.0 2.3 1 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESS69134.1 - 7.1e-07 29.4 0.0 2.5e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESS69134.1 - 3.5e-06 26.2 0.1 1.5e-05 24.2 0.0 2.0 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 ESS69134.1 - 9.7e-06 25.3 0.0 2.7e-05 23.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS69134.1 - 1.1e-05 25.0 0.1 2.9e-05 23.7 0.0 1.7 2 0 0 2 2 1 1 Part of AAA domain DUF2075 PF09848.4 ESS69134.1 - 0.0003 19.8 0.0 0.00043 19.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 ESS69134.1 - 0.0006 19.4 0.0 0.0012 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS69134.1 - 0.00096 19.0 0.0 0.0016 18.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 ESS69134.1 - 0.0013 18.5 0.0 0.0037 17.1 0.0 1.8 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_17 PF13207.1 ESS69134.1 - 0.0014 19.4 0.0 0.0044 17.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESS69134.1 - 0.0026 17.6 0.0 0.0057 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 ESS69134.1 - 0.0028 17.1 0.3 0.15 11.5 0.0 2.4 2 1 1 3 3 2 1 DEAD/DEAH box helicase Mg_chelatase PF01078.16 ESS69134.1 - 0.0034 16.5 0.1 0.0098 15.0 0.1 1.9 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ESS69134.1 - 0.0068 16.3 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESS69134.1 - 0.0092 15.7 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 ESS69134.1 - 0.026 13.9 0.6 0.27 10.6 0.4 2.2 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESS69134.1 - 0.034 14.4 0.0 0.068 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 ESS69134.1 - 0.038 13.5 0.0 0.08 12.4 0.0 1.6 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.4 ESS69134.1 - 0.044 12.3 0.0 0.076 11.6 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.13 ESS69134.1 - 0.047 13.1 0.1 0.13 11.7 0.0 1.6 1 1 0 1 1 1 0 FtsK/SpoIIIE family PEPCK_ATP PF01293.15 ESS69134.1 - 0.065 11.7 0.0 0.096 11.1 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase ArgK PF03308.11 ESS69134.1 - 0.098 11.4 0.2 4.1 6.1 0.0 2.1 1 1 1 2 2 2 0 ArgK protein Zot PF05707.7 ESS69134.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_3 PF07726.6 ESS69134.1 - 0.12 12.0 0.1 0.72 9.4 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESS69134.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) ABC_tran PF00005.22 ESS69134.1 - 0.14 12.4 0.0 0.39 11.0 0.0 1.5 1 1 0 1 1 1 0 ABC transporter NTPase_1 PF03266.10 ESS69134.1 - 0.15 11.7 0.0 0.38 10.4 0.0 1.8 2 0 0 2 2 1 0 NTPase AAA_32 PF13654.1 ESS69134.1 - 0.15 10.6 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain FTHFS PF01268.14 ESS69135.1 - 6.9e-253 839.6 0.0 7.8e-253 839.5 0.0 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase Leu_Phe_trans PF03588.9 ESS69136.1 - 2.3e-06 26.8 0.0 3.2e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase DnaJ PF00226.26 ESS69137.1 - 4.6e-07 29.4 0.0 8.2e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Reticulon PF02453.12 ESS69138.1 - 1.2e-15 57.4 0.4 1.6e-15 57.1 0.3 1.1 1 0 0 1 1 1 1 Reticulon Mt_ATP-synt_D PF05873.7 ESS69138.1 - 0.011 15.4 0.2 0.013 15.1 0.1 1.1 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Remorin_C PF03763.8 ESS69138.1 - 0.013 15.0 2.6 0.016 14.7 1.8 1.1 1 0 0 1 1 1 0 Remorin, C-terminal region PRT_C PF08372.5 ESS69138.1 - 0.03 13.8 0.1 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal DUF2232 PF09991.4 ESS69138.1 - 0.046 12.7 0.0 0.05 12.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) GtrA PF04138.9 ESS69138.1 - 0.046 13.6 0.3 0.052 13.5 0.2 1.1 1 0 0 1 1 1 0 GtrA-like protein PrgI PF12666.2 ESS69138.1 - 0.1 12.7 0.5 0.14 12.3 0.4 1.3 1 1 0 1 1 1 0 PrgI family protein Cofilin_ADF PF00241.15 ESS69139.1 - 0.027 14.3 0.0 0.78 9.6 0.0 2.8 3 0 0 3 3 3 0 Cofilin/tropomyosin-type actin-binding protein NAD_binding_6 PF08030.7 ESS69140.1 - 0.041 13.7 1.9 0.041 13.8 0.4 1.7 2 0 0 2 2 2 0 Ferric reductase NAD binding domain RRM_1 PF00076.17 ESS69142.1 - 1.8e-08 33.9 0.0 2.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69142.1 - 0.00012 21.9 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69142.1 - 0.003 17.3 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA_m1G_MT PF01746.16 ESS69146.1 - 4.4e-26 91.6 0.1 9.3e-26 90.5 0.0 1.5 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase TAF1D PF15333.1 ESS69148.1 - 0.04 13.7 4.9 0.048 13.4 3.4 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D RRM_1 PF00076.17 ESS69150.1 - 8.9e-15 54.0 0.0 2.8e-14 52.5 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69150.1 - 8.9e-13 48.0 0.0 1.8e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69150.1 - 1.2e-07 31.4 0.0 2.1e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_A_type_inc PF04508.7 ESS69150.1 - 0.16 11.7 1.0 0.41 10.5 0.7 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat YbaB_DNA_bd PF02575.11 ESS69150.1 - 6.8 6.6 7.6 0.74 9.7 0.9 2.1 2 0 0 2 2 2 0 YbaB/EbfC DNA-binding family TMA7 PF09072.5 ESS69151.1 - 1.8e-20 73.1 10.0 1.9e-20 73.0 6.9 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 PKK PF12474.3 ESS69151.1 - 0.063 12.9 2.9 0.059 13.1 2.0 1.0 1 0 0 1 1 1 0 Polo kinase kinase zf-CHCC PF10276.4 ESS69152.1 - 0.0016 18.2 2.4 0.0016 18.2 1.7 2.2 3 0 0 3 3 3 1 Zinc-finger domain Chlam_PMP PF02415.12 ESS69152.1 - 0.086 13.1 0.0 9.5 6.7 0.0 2.5 2 0 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat LRR_6 PF13516.1 ESS69153.1 - 2.4e-07 30.1 1.8 0.013 15.4 0.2 3.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 ESS69153.1 - 3.4e-05 23.3 4.5 0.0036 16.9 2.2 3.6 2 2 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS69153.1 - 8.1e-05 22.1 1.0 0.99 9.6 0.1 3.5 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_8 PF13855.1 ESS69153.1 - 0.00023 20.8 4.0 0.0023 17.6 2.0 2.5 1 1 1 2 2 2 1 Leucine rich repeat LRR_7 PF13504.1 ESS69153.1 - 0.0093 15.9 1.0 4.7 7.8 0.0 3.5 3 0 0 3 3 3 1 Leucine rich repeat FUN14 PF04930.10 ESS69154.1 - 1.7e-21 76.3 0.6 2.2e-21 76.0 0.4 1.1 1 0 0 1 1 1 1 FUN14 family EF-hand_6 PF13405.1 ESS69154.1 - 0.0019 17.9 0.1 0.0039 16.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 ESS69154.1 - 0.013 14.7 0.1 0.022 14.0 0.1 1.4 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.1 ESS69154.1 - 0.024 14.2 0.1 0.047 13.3 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 ESS69154.1 - 0.03 13.6 0.1 0.053 12.8 0.1 1.4 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 ESS69154.1 - 0.049 13.7 0.1 0.078 13.1 0.1 1.3 1 0 0 1 1 1 0 EF-hand domain pair TRAP_beta PF05753.9 ESS69155.1 - 8.1e-34 116.3 1.0 1.2e-33 115.8 0.7 1.2 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF11 PF01345.13 ESS69155.1 - 1.9e-08 34.2 0.9 1.9e-08 34.2 0.6 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF11 CARDB PF07705.6 ESS69155.1 - 1.5e-07 31.3 0.2 2.4e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 CARDB NPCBM_assoc PF10633.4 ESS69155.1 - 0.013 15.5 0.2 0.032 14.2 0.1 1.7 1 1 0 1 1 1 0 NPCBM-associated, NEW3 domain of alpha-galactosidase BatD PF13584.1 ESS69155.1 - 0.063 11.8 0.1 0.12 11.0 0.0 1.4 2 0 0 2 2 2 0 Oxygen tolerance A2M PF00207.17 ESS69155.1 - 0.09 12.3 0.6 0.33 10.5 0.1 2.0 2 0 0 2 2 2 0 Alpha-2-macroglobulin family ubiquitin PF00240.18 ESS69156.1 - 0.016 14.5 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family LSM PF01423.17 ESS69158.1 - 2.2e-09 36.7 0.1 3.4e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 LSM domain ZU5 PF00791.15 ESS69158.1 - 0.056 13.1 0.0 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 ZU5 domain tRNA-synt_1 PF00133.17 ESS69160.1 - 6.4e-187 622.2 0.0 2.9e-186 620.0 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESS69160.1 - 2e-34 118.5 0.0 3.4e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESS69160.1 - 1.8e-15 56.4 0.3 3e-07 29.4 0.0 3.7 3 1 0 3 3 3 3 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.4 ESS69160.1 - 6.8e-14 51.7 2.9 1.5e-13 50.5 2.0 1.6 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.1 ESS69160.1 - 2.3e-06 27.0 0.0 0.032 13.5 0.0 2.5 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1d PF00750.14 ESS69160.1 - 0.0083 14.9 0.1 0.72 8.6 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (R) tRNA-synt_1b PF00579.20 ESS69160.1 - 0.084 11.9 0.2 0.19 10.8 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) tRNA-synt_1e PF01406.14 ESS69160.1 - 0.085 11.9 0.6 2.5 7.1 0.0 3.0 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain SH3_3 PF08239.6 ESS69207.1 - 0.00021 21.4 0.3 0.15 12.2 0.0 2.6 2 0 0 2 2 2 2 Bacterial SH3 domain ABC_membrane_2 PF06472.10 ESS69208.1 - 1.4e-28 99.8 3.4 2e-28 99.3 2.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESS69208.1 - 3.9e-16 59.5 0.0 8.4e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESS69208.1 - 2.5e-07 30.1 0.1 1.3e-05 24.5 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESS69208.1 - 0.00018 21.5 0.0 0.0029 17.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 ESS69208.1 - 0.0036 16.9 0.0 0.009 15.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain SbcCD_C PF13558.1 ESS69208.1 - 0.0039 17.0 0.0 0.0095 15.8 0.0 1.6 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.1 ESS69208.1 - 0.017 15.4 0.0 0.04 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESS69208.1 - 0.021 14.8 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF2813 PF11398.3 ESS69208.1 - 0.024 13.7 0.1 0.14 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) AAA_15 PF13175.1 ESS69208.1 - 0.086 11.8 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Vasohibin PF14822.1 ESS69209.1 - 2e-54 184.3 0.0 3.1e-54 183.6 0.0 1.2 1 0 0 1 1 1 1 Vasohibin Brix PF04427.13 ESS69210.1 - 1.1e-42 145.9 0.3 1.8e-42 145.2 0.2 1.3 1 0 0 1 1 1 1 Brix domain PfkB PF00294.19 ESS69213.1 - 1.3e-64 218.2 0.1 1.6e-64 217.9 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 ESS69213.1 - 4.8e-11 42.3 0.0 7.3e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Gly_reductase PF09338.6 ESS69213.1 - 0.056 11.6 1.5 0.056 11.6 0.3 1.5 2 0 0 2 2 2 0 Glycine/sarcosine/betaine reductase component B subunits DnaJ PF00226.26 ESS69214.1 - 8.4e-24 83.0 1.7 1.8e-23 82.0 1.2 1.6 1 0 0 1 1 1 1 DnaJ domain APG9 PF04109.11 ESS69215.1 - 4.5e-72 243.0 1.0 4.5e-72 243.0 0.7 1.6 2 0 0 2 2 2 1 Autophagy protein Apg9 Nup96 PF12110.3 ESS69216.1 - 3.9e-31 108.2 0.0 6.2e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 ESS69216.1 - 2e-21 76.2 0.0 4.5e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin autopeptidase AAA PF00004.24 ESS69217.1 - 9.5e-37 126.1 0.0 1.4e-35 122.3 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS69217.1 - 0.00068 19.6 0.1 0.035 14.0 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 ESS69217.1 - 0.0061 16.2 0.0 0.02 14.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESS69217.1 - 0.0061 16.4 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESS69217.1 - 0.073 12.7 0.0 6.8 6.3 0.0 2.5 1 1 1 2 2 2 0 Archaeal ATPase HD PF01966.17 ESS69217.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 HD domain Rad17 PF03215.10 ESS69217.1 - 0.27 9.8 0.0 0.59 8.7 0.0 1.4 1 1 0 1 1 1 0 Rad17 cell cycle checkpoint protein RRM_1 PF00076.17 ESS69218.1 - 1.2e-13 50.4 0.0 1.2e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69218.1 - 3.2e-10 39.6 0.0 1.1e-09 38.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69218.1 - 1.1e-09 38.1 0.0 3.4e-08 33.3 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF3592 PF12158.3 ESS69220.1 - 0.01 15.6 1.0 2 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3592) Rifin_STEVOR PF02009.11 ESS69220.1 - 0.01 15.5 0.6 0.016 14.8 0.4 1.6 1 1 0 1 1 1 0 Rifin/stevor family m04gp34like PF12216.3 ESS69220.1 - 0.057 12.7 0.1 0.13 11.5 0.1 1.5 1 0 0 1 1 1 0 Immune evasion protein Adeno_E3_CR2 PF02439.10 ESS69220.1 - 0.11 12.0 4.6 0.22 11.0 3.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Herpes_gE PF02480.11 ESS69220.1 - 0.14 10.3 0.0 0.14 10.3 0.0 1.4 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Ly49 PF08391.5 ESS69220.1 - 0.16 12.1 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF2371 PF10177.4 ESS69220.1 - 0.16 11.8 0.7 4.3 7.1 0.2 2.5 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) TMEM154 PF15102.1 ESS69220.1 - 0.66 9.6 6.0 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 TMEM154 protein family Golgin_A5 PF09787.4 ESS69220.1 - 4.3 5.7 7.6 5.5 5.3 5.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 AKNA PF12443.3 ESS69221.1 - 0.0084 16.1 0.7 0.055 13.4 0.4 2.4 2 0 0 2 2 2 1 AT-hook-containing transcription factor SlyX PF04102.7 ESS69221.1 - 3.1 8.2 11.4 39 4.6 0.1 4.0 2 1 0 3 3 3 0 SlyX TIP120 PF08623.5 ESS69223.1 - 2.8e-08 33.5 1.0 5.8e-07 29.2 0.1 3.2 2 1 0 2 2 2 1 TATA-binding protein interacting (TIP20) HEAT PF02985.17 ESS69224.1 - 9.6e-06 25.2 1.4 1.6 8.9 0.0 6.3 7 0 0 7 7 7 2 HEAT repeat DUF1546 PF07571.8 ESS69224.1 - 0.13 12.4 0.0 0.66 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1546) TPR_11 PF13414.1 ESS69227.1 - 6e-07 29.0 1.5 4.8e-05 22.9 0.0 3.3 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.1 ESS69227.1 - 0.0016 18.9 1.7 3.3 8.6 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS69227.1 - 0.014 15.5 2.8 0.14 12.3 0.0 3.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS69227.1 - 0.028 14.3 0.3 2.1 8.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69227.1 - 0.045 14.1 0.4 0.87 9.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4413 PF14372.1 ESS69227.1 - 0.062 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) TPR_16 PF13432.1 ESS69227.1 - 3.3 8.5 9.3 5.7 7.7 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS69228.1 - 2.5e-12 46.5 28.0 0.0048 16.8 0.4 7.7 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 ESS69228.1 - 3.6e-06 26.5 16.8 0.051 13.2 0.1 5.8 5 1 1 6 6 6 4 TPR repeat TPR_7 PF13176.1 ESS69228.1 - 0.00089 18.8 12.6 5.1 7.1 0.2 7.9 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69228.1 - 0.0087 16.3 9.4 0.34 11.2 0.1 4.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESS69228.1 - 0.016 15.1 15.5 2.5 8.2 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat Pax7 PF12360.3 ESS69228.1 - 0.025 14.8 0.2 0.025 14.8 0.1 2.0 2 0 0 2 2 2 0 Paired box protein 7 Apc3 PF12895.2 ESS69228.1 - 0.029 14.5 8.8 12 6.1 0.1 4.8 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS69228.1 - 0.048 14.3 14.5 9.8 7.1 0.0 6.9 5 3 4 9 9 9 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS69228.1 - 0.086 13.3 6.5 5.4 7.6 0.1 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS69228.1 - 1.3 8.7 10.9 2.8 7.7 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat LRR_8 PF13855.1 ESS69232.1 - 6.4e-17 61.0 10.3 5.9e-14 51.5 0.4 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ESS69232.1 - 5.8e-12 44.9 2.2 8e-05 22.1 0.0 4.1 2 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS69232.1 - 2.3e-05 23.8 9.4 1.1 9.5 0.2 6.3 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.1 ESS69232.1 - 0.00045 20.0 4.5 26 5.2 0.2 5.6 4 1 0 4 4 4 1 Leucine Rich repeat LRR_7 PF13504.1 ESS69232.1 - 0.009 16.0 4.4 18 6.0 0.1 5.3 3 1 0 3 3 3 2 Leucine rich repeat RIO1 PF01163.17 ESS69233.1 - 9.5e-06 25.0 0.0 1.6e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.20 ESS69233.1 - 2.4e-05 23.6 0.0 3.1e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESS69233.1 - 0.00019 20.5 0.0 0.00035 19.6 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESS69233.1 - 0.003 16.6 0.0 0.0035 16.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Lysis_S PF04971.7 ESS69234.1 - 0.36 10.5 2.3 2.2 8.0 0.1 3.1 3 0 0 3 3 3 0 Lysis protein S RhoGAP PF00620.22 ESS69237.1 - 0.00071 19.2 1.4 0.0013 18.3 0.2 2.0 2 0 0 2 2 2 1 RhoGAP domain Het-C PF07217.6 ESS69237.1 - 0.0055 14.9 0.1 0.0055 14.9 0.1 1.8 2 0 0 2 2 2 1 Heterokaryon incompatibility protein Het-C TMF_TATA_bd PF12325.3 ESS69237.1 - 0.13 12.0 9.4 0.27 10.9 1.6 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding PH PF00169.24 ESS69238.1 - 0.0017 18.5 0.2 0.006 16.7 0.0 2.0 2 1 0 2 2 2 1 PH domain TPR_1 PF00515.23 ESS69239.1 - 0.0041 16.6 0.1 0.26 10.9 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS69239.1 - 0.0049 16.6 1.4 0.67 10.0 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS69239.1 - 0.015 14.9 0.0 0.82 9.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESS69239.1 - 0.026 14.1 2.5 1.9 8.1 0.0 2.7 2 1 0 3 3 3 0 TPR repeat TPR_14 PF13428.1 ESS69239.1 - 0.17 12.6 2.6 0.72 10.6 0.9 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 ESS69240.1 - 2.8e-46 157.7 1.2 1e-25 90.3 0.0 3.7 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69240.1 - 4e-14 52.3 0.2 2.5e-08 33.2 0.0 3.5 4 0 0 4 4 4 2 Protein tyrosine kinase Kdo PF06293.9 ESS69240.1 - 3.8e-05 22.8 0.1 7.2e-05 21.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS69240.1 - 0.011 15.4 0.4 0.047 13.4 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Cyclin_N PF00134.18 ESS69241.1 - 1.1e-08 34.7 0.0 1.8e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain PP2C PF00481.16 ESS69242.1 - 1.9e-55 188.0 0.1 2.9e-55 187.4 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SNF2_N PF00176.18 ESS69243.1 - 2.5e-66 223.5 0.0 1.2e-36 126.0 0.0 2.7 2 1 0 2 2 2 2 SNF2 family N-terminal domain zf-PARP PF00645.13 ESS69243.1 - 1.6e-14 53.8 0.2 4.9e-14 52.3 0.2 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-RING_2 PF13639.1 ESS69243.1 - 2.5e-07 30.4 3.6 2.5e-07 30.4 2.5 3.6 4 0 0 4 4 3 1 Ring finger domain zf-Apc11 PF12861.2 ESS69243.1 - 1.9e-05 24.3 1.0 1.9e-05 24.3 0.7 3.0 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 ESS69243.1 - 4.7e-05 22.9 3.8 4.7e-05 22.9 2.7 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS69243.1 - 0.00012 21.9 4.1 0.00012 21.9 2.8 3.4 5 0 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESS69243.1 - 0.00018 21.5 1.2 0.00018 21.5 0.8 2.7 4 0 0 4 4 2 1 RING-H2 zinc finger ResIII PF04851.10 ESS69243.1 - 0.0014 18.5 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.1 ESS69243.1 - 0.039 13.6 1.3 0.15 11.7 0.9 2.2 1 0 0 1 1 1 0 RING-type zinc-finger FYDLN_acid PF09538.5 ESS69243.1 - 0.041 14.4 3.6 0.19 12.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) RINGv PF12906.2 ESS69243.1 - 0.063 13.3 2.6 0.25 11.4 1.8 2.2 1 0 0 1 1 1 0 RING-variant domain DUF4422 PF14393.1 ESS69243.1 - 0.077 12.5 0.1 1.9 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4422) zinc_ribbon_4 PF13717.1 ESS69243.1 - 1.1 8.9 9.5 40 4.0 0.2 4.9 4 0 0 4 4 4 0 zinc-ribbon domain zf-RING_4 PF14570.1 ESS69243.1 - 3.1 7.4 16.5 0.71 9.4 2.2 3.8 4 0 0 4 4 3 0 RING/Ubox like zinc-binding domain SCAMP PF04144.8 ESS69245.1 - 5.3e-32 111.1 13.0 7.6e-32 110.6 9.0 1.1 1 0 0 1 1 1 1 SCAMP family DUF3776 PF12618.3 ESS69245.1 - 0.02 15.4 6.3 0.046 14.2 4.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3776) DUF606 PF04657.8 ESS69245.1 - 0.029 14.4 4.6 0.047 13.7 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF606 Sigma_reg_N PF13800.1 ESS69245.1 - 1.9 8.5 6.2 16 5.5 0.2 3.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal RDD PF06271.7 ESS69245.1 - 6.7 6.6 11.5 0.13 12.1 1.3 2.2 2 0 0 2 2 2 0 RDD family DUF3774 PF12609.3 ESS69246.1 - 1 10.2 3.4 0.61 10.9 0.2 2.2 3 0 0 3 3 3 0 Wound-induced protein ENTH PF01417.15 ESS69248.1 - 9.4e-27 93.3 0.0 1.5e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 ENTH domain CCDC50_N PF15295.1 ESS69248.1 - 0.059 13.2 6.6 0.69 9.8 0.5 2.8 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus PPR PF01535.15 ESS69249.1 - 3.1e-05 23.6 0.9 0.00058 19.6 0.1 2.6 2 0 0 2 2 2 1 PPR repeat PPR_2 PF13041.1 ESS69249.1 - 0.00013 21.9 0.7 0.00062 19.6 0.1 2.1 1 1 1 2 2 2 1 PPR repeat family RNA_pol_Rpb2_6 PF00562.23 ESS69250.1 - 4.5e-89 298.8 0.0 6.3e-89 298.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpa2_4 PF06883.7 ESS69250.1 - 8.3e-18 64.0 0.1 2.3e-17 62.6 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_3 PF04565.11 ESS69250.1 - 1.4e-14 53.5 0.0 2.9e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.15 ESS69250.1 - 3.5e-12 46.3 0.2 1.3e-11 44.6 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.10 ESS69250.1 - 5.6e-09 35.2 0.0 3.9e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase beta subunit Raptor_N PF14538.1 ESS69251.1 - 9.5e-55 184.6 0.0 2e-54 183.6 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT_2 PF13646.1 ESS69251.1 - 0.016 15.5 0.7 0.16 12.2 0.0 2.9 2 1 1 3 3 3 0 HEAT repeats HEAT PF02985.17 ESS69251.1 - 0.065 13.3 0.0 0.065 13.3 0.0 3.9 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.1 ESS69251.1 - 3.7 8.1 6.8 29 5.3 0.7 3.8 2 1 1 3 3 3 0 HEAT-like repeat Cyclin PF08613.6 ESS69252.1 - 2.1e-05 24.9 0.2 3e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESS69252.1 - 0.00036 20.1 0.1 0.00084 18.9 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain LSM14 PF12701.2 ESS69254.1 - 2e-29 101.2 0.0 4.1e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.1 ESS69254.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain BAF1_ABF1 PF04684.8 ESS69254.1 - 0.76 8.5 10.8 1.7 7.3 7.5 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Bap31 PF05529.7 ESS69254.1 - 2 7.8 4.2 1.1 8.6 0.6 1.9 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like GRP PF07172.6 ESS69254.1 - 2.6 8.5 25.0 0.075 13.5 6.6 3.5 3 1 0 3 3 3 0 Glycine rich protein family FDF PF09532.5 ESS69254.1 - 6.6 7.3 29.3 10 6.7 10.6 3.9 3 1 0 3 3 3 0 FDF domain SelP_N PF04592.9 ESS69254.1 - 8.6 5.6 9.3 0.47 9.7 2.5 1.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF2451 PF10474.4 ESS69257.1 - 1e-05 25.4 0.0 2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) DUF2121 PF09894.4 ESS69257.1 - 0.05 12.8 0.3 3.6 6.8 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2121) DUF2450 PF10475.4 ESS69257.1 - 0.06 12.2 2.7 0.053 12.4 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function N-terminal domain (DUF2450) RasGEF PF00617.14 ESS69258.1 - 3.5e-29 101.8 0.1 5.3e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 ESS69258.1 - 3.8e-19 68.7 0.6 1.1e-18 67.2 0.1 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif ABC_membrane PF00664.18 ESS69259.1 - 6.1e-45 153.7 3.5 8.3e-45 153.3 2.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 ESS69259.1 - 7.5e-35 120.2 0.0 1.7e-34 119.0 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 ESS69259.1 - 2.2e-05 24.6 0.1 0.079 12.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 ESS69259.1 - 0.00016 20.9 0.0 0.14 11.3 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 ESS69259.1 - 0.001 19.2 0.6 0.036 14.2 0.4 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS69259.1 - 0.0024 17.8 0.1 0.013 15.5 0.0 2.1 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.24 ESS69259.1 - 0.0042 17.2 0.0 0.035 14.2 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.4 ESS69259.1 - 0.015 13.9 0.0 0.028 13.0 0.0 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_29 PF13555.1 ESS69259.1 - 0.018 14.5 0.0 0.045 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 ESS69259.1 - 0.032 13.3 0.0 0.064 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 ESS69259.1 - 0.037 13.4 0.1 0.19 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESS69259.1 - 0.039 13.4 0.1 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain DUF87 PF01935.12 ESS69259.1 - 0.04 13.7 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 DUF258 PF03193.11 ESS69259.1 - 0.044 12.9 0.0 0.081 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESS69259.1 - 0.085 13.6 0.0 0.18 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 ESS69259.1 - 0.12 12.2 0.2 0.58 10.1 0.2 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.9 ESS69259.1 - 0.16 11.7 0.2 0.67 9.6 0.0 2.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) RRM_1 PF00076.17 ESS69262.1 - 1.3e-21 75.9 0.0 1.9e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69262.1 - 8.7e-15 54.4 0.0 1.5e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69262.1 - 3.8e-12 45.8 0.0 5.9e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myosin_head PF00063.16 ESS69263.1 - 4.3e-93 312.6 0.0 6e-85 285.7 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_22 PF13401.1 ESS69263.1 - 0.0091 16.1 0.0 0.038 14.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS69263.1 - 0.015 15.0 0.9 0.14 11.9 0.0 3.0 3 0 0 3 3 3 0 Part of AAA domain AAA_18 PF13238.1 ESS69263.1 - 1.2 9.4 6.3 7 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Kringle PF00051.13 ESS69264.1 - 1.2e-19 70.2 0.2 3e-19 68.9 0.2 1.6 1 0 0 1 1 1 1 Kringle domain CHB_HEX_C_1 PF13290.1 ESS69264.1 - 3.4e-17 61.9 0.2 3e-14 52.5 0.2 3.4 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C PF03174.8 ESS69264.1 - 3.8e-15 55.4 0.1 4.6e-13 48.8 0.1 3.4 3 0 0 3 3 3 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 ESS69264.1 - 2.7e-13 49.7 0.2 6.2e-11 42.2 0.2 3.3 3 0 0 3 3 3 1 Fn3 associated MMR_HSR1 PF01926.18 ESS69265.1 - 3.3e-13 49.5 0.0 5.9e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS69265.1 - 9.1e-10 38.0 0.0 1e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESS69265.1 - 4.1e-05 23.4 0.4 0.025 14.3 0.1 2.4 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.5 ESS69265.1 - 0.0017 17.5 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 ESS69265.1 - 0.0018 17.5 0.1 0.0034 16.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESS69265.1 - 0.0021 17.5 0.1 0.26 10.6 0.0 2.8 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.1 ESS69265.1 - 0.0095 15.9 2.8 1.1 9.1 0.0 3.5 3 1 1 4 4 4 1 AAA domain AAA_21 PF13304.1 ESS69265.1 - 0.018 15.0 0.2 0.03 14.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.11 ESS69265.1 - 0.063 12.3 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 AIG1 family AAA_23 PF13476.1 ESS69265.1 - 0.072 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.7 ESS69265.1 - 0.16 11.0 0.2 0.58 9.2 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region TFIIB PF00382.14 ESS69266.1 - 1.5e-23 82.4 0.0 1.7e-11 43.7 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 ESS69266.1 - 0.0046 16.2 0.0 0.01 15.1 0.0 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding WD40 PF00400.27 ESS69267.1 - 1.2e-48 161.3 12.0 3.4e-11 42.5 0.2 10.1 10 0 0 10 10 10 8 WD domain, G-beta repeat Utp13 PF08625.6 ESS69267.1 - 4.8e-42 142.9 0.8 8.1e-42 142.2 0.5 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Utp12 PF04003.7 ESS69267.1 - 2.9e-05 23.9 1.2 5.3e-05 23.0 0.9 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Nucleoporin_N PF08801.6 ESS69267.1 - 0.0031 16.3 0.4 1.3 7.6 0.0 4.6 2 2 2 4 4 4 1 Nup133 N terminal like Cytochrom_D1 PF02239.11 ESS69267.1 - 0.05 11.8 0.0 0.34 9.1 0.0 2.3 2 1 0 2 2 2 0 Cytochrome D1 heme domain UTP15_C PF09384.5 ESS69267.1 - 0.12 12.0 0.5 0.28 10.8 0.4 1.6 1 1 0 1 1 1 0 UTP15 C terminal Baculo_PEP_C PF04513.7 ESS69268.1 - 4.6e-06 26.4 32.4 0.026 14.3 0.4 6.2 2 1 2 6 6 6 3 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.3 ESS69268.1 - 8.8e-06 23.3 36.8 0.00019 18.9 6.6 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) Apolipoprotein PF01442.13 ESS69268.1 - 0.00015 21.3 39.9 0.001 18.6 6.2 4.2 2 1 2 5 5 5 3 Apolipoprotein A1/A4/E domain DUF1664 PF07889.7 ESS69268.1 - 0.0093 15.7 31.2 0.11 12.2 0.7 6.4 4 1 2 7 7 7 3 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 ESS69268.1 - 0.033 14.3 32.5 0.25 11.4 0.5 5.4 4 1 1 6 6 6 0 Fibrinogen alpha/beta chain family NAAA-beta PF15508.1 ESS69268.1 - 0.034 14.5 5.4 67 3.9 0.0 5.9 3 2 2 6 6 6 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Tweety PF04906.8 ESS69268.1 - 0.061 11.7 20.7 0.34 9.2 1.2 3.7 2 1 1 3 3 3 0 Tweety Prismane PF03063.15 ESS69268.1 - 1.1 7.5 3.8 0.87 7.8 0.6 2.1 1 1 1 2 2 2 0 Prismane/CO dehydrogenase family Cor1 PF04803.7 ESS69268.1 - 1.3 8.8 19.3 0.017 14.8 1.5 4.3 3 2 1 4 4 4 0 Cor1/Xlr/Xmr conserved region FAD-SLDH PF12318.3 ESS69268.1 - 1.9 8.1 9.8 4.8 6.8 0.4 3.7 3 2 2 5 5 5 0 Membrane bound FAD containing D-sorbitol dehydrogenase NPV_P10 PF05531.7 ESS69268.1 - 3.4 7.9 25.7 0.19 11.9 1.1 7.0 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein SUI1 PF01253.17 ESS69269.1 - 7.7e-19 67.2 0.1 1.6e-18 66.2 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 bZIP_1 PF00170.16 ESS69270.1 - 0.0009 19.1 0.9 0.0009 19.1 0.6 5.7 6 0 0 6 6 6 2 bZIP transcription factor ADIP PF11559.3 ESS69270.1 - 0.0025 17.7 0.5 0.0025 17.7 0.3 5.2 5 0 0 5 5 5 2 Afadin- and alpha -actinin-Binding GAS PF13851.1 ESS69270.1 - 0.0069 15.5 0.6 0.0069 15.5 0.4 5.7 6 1 0 6 6 6 2 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.7 ESS69270.1 - 0.24 11.6 6.0 0.37 11.0 0.3 3.7 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF2205 PF10224.4 ESS69270.1 - 0.88 9.1 20.5 0.71 9.4 0.3 4.6 4 0 0 4 4 4 0 Predicted coiled-coil protein (DUF2205) CENP-F_leu_zip PF10473.4 ESS69270.1 - 1.2 9.0 40.8 0.14 12.0 0.6 5.1 5 0 0 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 ESS69270.1 - 1.9 8.0 44.4 4 6.9 0.5 5.3 4 1 1 5 5 5 0 IncA protein DUF1192 PF06698.6 ESS69270.1 - 1.9 8.3 8.4 3.4 7.5 0.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) Striatin PF08232.7 ESS69270.1 - 2.5 8.4 27.6 29 4.9 6.6 5.4 3 2 1 4 4 4 0 Striatin family Herpes_BLRF2 PF05812.7 ESS69270.1 - 3.1 7.6 15.8 0.14 11.9 0.3 3.8 4 0 0 4 4 4 0 Herpesvirus BLRF2 protein Reo_sigmaC PF04582.7 ESS69270.1 - 5.7 6.0 12.5 0.51 9.4 0.4 3.5 2 2 1 3 3 3 0 Reovirus sigma C capsid protein DUF3450 PF11932.3 ESS69270.1 - 9.5 5.3 17.7 0.32 10.2 1.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF3450) zf-RING_2 PF13639.1 ESS69271.1 - 4e-11 42.5 9.1 4e-11 42.5 6.3 3.2 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESS69271.1 - 2.2e-06 27.2 7.4 2.2e-06 27.2 5.1 2.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS69271.1 - 6.7e-06 26.0 8.6 6.7e-06 26.0 6.0 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESS69271.1 - 2.1e-05 24.5 3.3 2.1e-05 24.5 2.3 3.1 4 0 0 4 4 4 1 RING-H2 zinc finger zf-RING_5 PF14634.1 ESS69271.1 - 0.00016 21.3 7.7 0.00016 21.3 5.3 2.5 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESS69271.1 - 0.00031 20.3 8.7 0.00031 20.3 6.1 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.1 ESS69271.1 - 0.041 13.8 3.9 0.15 12.0 2.7 2.0 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-Nse PF11789.3 ESS69271.1 - 0.061 12.8 2.6 0.18 11.3 1.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-Apc11 PF12861.2 ESS69271.1 - 0.33 10.8 11.6 0.069 12.9 4.0 3.0 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 ESS69271.1 - 0.65 9.7 13.0 0.63 9.7 5.7 3.4 3 0 0 3 3 3 0 PHD-finger zf-RING_4 PF14570.1 ESS69271.1 - 8.3 6.0 13.0 1.5 8.5 5.2 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain SPRY PF00622.23 ESS69272.1 - 5.7e-09 36.1 0.0 1.6e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 SPRY domain ATP_bind_4 PF01902.12 ESS69274.1 - 8.4e-29 100.5 0.0 2.8e-27 95.5 0.0 2.3 1 1 0 1 1 1 1 ATP-binding region YfhD PF14151.1 ESS69274.1 - 0.19 11.8 0.1 0.33 11.1 0.1 1.3 1 0 0 1 1 1 0 YfhD-like protein RRM_1 PF00076.17 ESS69275.1 - 5.2e-06 25.9 0.0 9.8e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YTH PF04146.10 ESS69275.1 - 9.5e-05 22.0 0.0 0.00055 19.5 0.0 2.0 1 1 0 1 1 1 1 YT521-B-like domain RRM_6 PF14259.1 ESS69275.1 - 0.00039 20.3 0.0 0.00084 19.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) BA14K PF07886.6 ESS69275.1 - 0.22 11.2 1.6 0.42 10.3 1.1 1.4 1 0 0 1 1 1 0 BA14K-like protein DUF641 PF04859.7 ESS69276.1 - 0.036 13.8 3.4 0.46 10.2 0.1 2.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) HAP1_N PF04849.8 ESS69276.1 - 0.17 10.8 16.9 0.0077 15.2 5.4 2.6 2 1 1 3 3 3 0 HAP1 N-terminal conserved region TPD52 PF04201.10 ESS69276.1 - 0.2 11.3 6.3 0.87 9.3 3.4 2.6 2 1 0 2 2 2 0 Tumour protein D52 family Phage_GP20 PF06810.6 ESS69277.1 - 0.0045 16.4 1.8 0.0045 16.4 1.2 4.4 5 0 0 5 5 5 1 Phage minor structural protein GP20 DUF3220 PF11516.3 ESS69277.1 - 0.036 14.0 0.3 9.8 6.2 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3120) TPR_MLP1_2 PF07926.7 ESS69278.1 - 0.089 12.5 3.7 0.63 9.7 2.5 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.1 ESS69278.1 - 0.16 11.9 5.8 0.38 10.7 4.0 1.7 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Prefoldin_2 PF01920.15 ESS69278.1 - 0.22 11.2 4.4 2.1 8.1 3.0 2.2 1 1 0 1 1 1 0 Prefoldin subunit IncA PF04156.9 ESS69278.1 - 0.65 9.5 5.8 1.4 8.5 4.1 1.5 1 0 0 1 1 1 0 IncA protein BicD PF09730.4 ESS69279.1 - 0.00029 19.3 5.0 0.00034 19.1 3.5 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Not3 PF04065.10 ESS69279.1 - 0.0013 18.0 4.9 0.0017 17.6 3.4 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Tup_N PF08581.5 ESS69279.1 - 0.0041 17.2 5.8 0.42 10.8 0.2 2.3 2 0 0 2 2 2 2 Tup N-terminal PLAC9 PF15205.1 ESS69279.1 - 0.019 15.2 0.5 0.043 14.0 0.3 1.6 1 0 0 1 1 1 0 Placenta-specific protein 9 RTBV_P46 PF06216.6 ESS69279.1 - 0.02 13.7 0.1 0.025 13.4 0.1 1.2 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein DUF3458 PF11940.3 ESS69279.1 - 0.027 13.3 0.5 0.034 12.9 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Filament PF00038.16 ESS69279.1 - 0.042 13.3 8.1 0.051 13.0 5.6 1.1 1 0 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.5 ESS69279.1 - 0.052 13.6 2.5 0.13 12.3 1.4 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FSA_C PF10479.4 ESS69279.1 - 0.073 11.1 2.1 0.088 10.8 1.4 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PXA PF02194.10 ESS69279.1 - 0.12 11.9 1.3 0.15 11.6 0.9 1.1 1 0 0 1 1 1 0 PXA domain Potyvirid-P3 PF13608.1 ESS69279.1 - 0.13 11.3 3.2 0.18 10.8 2.2 1.1 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein Peptidase_M41 PF01434.13 ESS69279.1 - 0.17 11.3 2.5 0.26 10.7 1.1 1.7 1 1 1 2 2 2 0 Peptidase family M41 Peptidase_C6 PF00851.13 ESS69279.1 - 0.2 10.2 2.3 0.25 9.9 1.6 1.1 1 0 0 1 1 1 0 Helper component proteinase Vicilin_N PF04702.7 ESS69279.1 - 0.36 10.4 4.9 0.5 9.9 3.4 1.2 1 0 0 1 1 1 0 Vicilin N terminal region zf-C4H2 PF10146.4 ESS69279.1 - 4.3 7.2 9.8 12 5.8 6.8 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein DSPc PF00782.15 ESS69280.1 - 4.8e-15 55.3 0.0 7.6e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ESS69280.1 - 0.0001 22.4 0.2 0.00021 21.3 0.0 1.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 ESS69280.1 - 0.0083 16.3 0.0 0.02 15.1 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESS69280.1 - 0.021 14.1 0.4 0.036 13.3 0.3 1.4 1 1 0 1 1 1 0 Protein-tyrosine phosphatase CDKN3 PF05706.7 ESS69280.1 - 0.027 13.9 0.1 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) GAGA PF09237.6 ESS69281.1 - 0.11 12.0 0.8 0.29 10.7 0.6 1.6 1 0 0 1 1 1 0 GAGA factor Spt5_N PF11942.3 ESS69281.1 - 0.15 12.6 7.7 0.85 10.2 1.2 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Mito_carr PF00153.22 ESS69282.1 - 9.7e-56 185.4 1.2 7.1e-19 67.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Clathrin PF00637.15 ESS69283.1 - 7.4e-07 28.8 3.8 0.17 11.4 0.2 4.0 3 1 1 4 4 4 3 Region in Clathrin and VPS TPR_14 PF13428.1 ESS69283.1 - 0.12 13.1 8.8 6.6 7.6 0.3 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat DZR PF12773.2 ESS69283.1 - 0.17 11.7 7.3 0.64 9.8 5.1 2.0 1 1 0 1 1 1 0 Double zinc ribbon TPR_7 PF13176.1 ESS69283.1 - 0.5 10.3 11.4 11 6.1 0.2 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat Peptidase_C12 PF01088.16 ESS69284.1 - 5.6e-61 205.4 0.0 6.4e-61 205.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 FAD_binding_2 PF00890.19 ESS69285.1 - 0.044 12.6 0.0 0.075 11.8 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Beta-Casp PF10996.3 ESS69286.1 - 6.4e-11 42.2 0.0 1.2e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain CPSF100_C PF13299.1 ESS69287.1 - 1.8e-24 86.7 0.0 2.8e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal APG6 PF04111.7 ESS69288.1 - 0.00047 19.3 5.8 0.00067 18.7 4.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Filament PF00038.16 ESS69288.1 - 0.0022 17.5 8.2 0.0022 17.5 5.7 2.0 2 0 0 2 2 2 1 Intermediate filament protein KLRAQ PF10205.4 ESS69288.1 - 0.0075 16.2 6.9 0.33 10.9 1.5 2.8 2 1 1 3 3 3 1 Predicted coiled-coil domain-containing protein COG2 PF06148.6 ESS69288.1 - 0.0091 15.8 3.1 0.019 14.8 2.1 1.5 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Spectrin PF00435.16 ESS69288.1 - 0.011 16.0 2.5 0.024 14.9 1.7 1.6 1 0 0 1 1 1 0 Spectrin repeat DUF641 PF04859.7 ESS69288.1 - 0.012 15.4 0.7 0.012 15.4 0.5 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Tropomyosin_1 PF12718.2 ESS69288.1 - 0.012 15.4 14.7 0.078 12.8 8.7 2.3 2 1 0 2 2 2 0 Tropomyosin like Myosin_tail_1 PF01576.14 ESS69288.1 - 0.02 12.6 10.6 0.0095 13.7 5.9 1.4 2 0 0 2 2 2 0 Myosin tail V_ATPase_I PF01496.14 ESS69288.1 - 0.036 11.9 3.3 0.048 11.5 2.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMF_TATA_bd PF12325.3 ESS69288.1 - 0.055 13.2 9.0 0.12 12.0 6.2 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding RTBV_P46 PF06216.6 ESS69288.1 - 0.096 11.5 2.6 0.14 11.0 1.8 1.1 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein ADIP PF11559.3 ESS69288.1 - 0.099 12.5 7.9 0.18 11.6 5.5 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.9 ESS69288.1 - 0.13 11.9 5.3 0.2 11.2 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FlxA PF14282.1 ESS69288.1 - 0.33 10.9 2.6 0.53 10.2 1.8 1.3 1 0 0 1 1 1 0 FlxA-like protein CENP-F_leu_zip PF10473.4 ESS69288.1 - 0.43 10.4 13.9 0.2 11.5 6.8 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TBPIP PF07106.8 ESS69288.1 - 0.43 10.1 5.6 0.71 9.4 3.9 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) YlqD PF11068.3 ESS69288.1 - 0.58 10.1 6.9 0.98 9.4 4.8 1.3 1 0 0 1 1 1 0 YlqD protein FlaC_arch PF05377.6 ESS69288.1 - 0.76 9.7 4.7 27 4.7 1.0 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF972 PF06156.8 ESS69288.1 - 0.79 10.1 10.1 0.39 11.0 2.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF972) IncA PF04156.9 ESS69288.1 - 1.1 8.8 15.3 2.6 7.5 8.5 2.3 2 1 1 3 3 3 0 IncA protein ATG16 PF08614.6 ESS69288.1 - 1.3 8.7 12.2 1.1 9.0 6.8 1.9 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Mnd1 PF03962.10 ESS69288.1 - 2.2 7.8 10.1 2.8 7.5 3.9 2.1 1 1 1 2 2 2 0 Mnd1 family DivIVA PF05103.8 ESS69288.1 - 6.8 6.7 10.7 2.9 7.9 2.4 2.7 2 1 1 3 3 3 0 DivIVA protein TMF_DNA_bd PF12329.3 ESS69288.1 - 9.6 6.0 12.9 3.9 7.3 5.9 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF3580 PF12117.3 ESS69289.1 - 0.14 12.1 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) GTP_EFTU PF00009.22 ESS69290.1 - 1.3e-50 171.4 0.1 2.2e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 ESS69290.1 - 5e-13 48.7 0.0 1.3e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 ESS69290.1 - 0.00012 22.0 0.1 0.00025 21.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESS69290.1 - 0.0014 18.7 0.2 0.005 16.9 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Septin PF00735.13 ESS69290.1 - 0.0047 15.9 0.1 0.0089 15.0 0.0 1.3 1 0 0 1 1 1 1 Septin Miro PF08477.8 ESS69290.1 - 0.012 16.0 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein DUF2293 PF10056.4 ESS69290.1 - 0.013 15.4 0.2 0.029 14.3 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) EFG_II PF14492.1 ESS69290.1 - 0.1 12.4 0.1 0.37 10.6 0.0 2.1 1 1 0 1 1 1 0 Elongation Factor G, domain II ETF PF01012.16 ESS69291.1 - 1.5e-36 125.6 0.2 1.9e-36 125.2 0.1 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain CCDC74_C PF14917.1 ESS69293.1 - 0.049 13.7 1.2 0.15 12.1 0.5 2.0 1 1 1 2 2 2 0 Coiled coil protein 74, C terminal RHSP PF07999.6 ESS69294.1 - 2.1e-119 399.0 0.3 2.1e-119 399.0 0.2 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein Cep57_CLD_2 PF14197.1 ESS69295.1 - 0.017 15.0 0.3 0.05 13.5 0.1 1.9 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF4164 PF13747.1 ESS69295.1 - 0.023 14.8 3.3 0.11 12.5 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) TBPIP PF07106.8 ESS69295.1 - 0.053 13.0 0.0 0.078 12.5 0.0 1.3 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) COG5 PF10392.4 ESS69295.1 - 0.057 13.3 0.1 0.14 12.1 0.0 1.6 1 1 0 1 1 1 0 Golgi transport complex subunit 5 CENP-F_leu_zip PF10473.4 ESS69295.1 - 0.063 13.1 0.0 7.2 6.4 0.0 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V-SNARE PF05008.10 ESS69295.1 - 0.074 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Fimbrial_CS1 PF04449.7 ESS69295.1 - 0.085 12.9 0.4 0.29 11.1 0.1 1.8 2 0 0 2 2 2 0 CS1 type fimbrial major subunit DUF2570 PF10828.3 ESS69295.1 - 0.1 12.1 0.5 0.97 9.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) YbaB_DNA_bd PF02575.11 ESS69295.1 - 4.3 7.2 5.4 4.9 7.1 0.5 2.2 2 0 0 2 2 2 0 YbaB/EbfC DNA-binding family PEP-utilisers_N PF05524.8 ESS69295.1 - 5.6 6.7 7.9 4.5 7.0 0.8 2.5 1 1 2 3 3 3 0 PEP-utilising enzyme, N-terminal Y_phosphatase2 PF03162.8 ESS69296.1 - 6e-38 129.7 0.0 7.2e-38 129.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESS69296.1 - 1.9e-05 24.9 0.0 2.8e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family MauE PF07291.6 ESS69296.1 - 0.05 13.2 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Methylamine utilisation protein MauE Dynein_light PF01221.13 ESS69297.1 - 4.1e-44 148.4 0.7 4.9e-44 148.2 0.5 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Imm28 PF15574.1 ESS69297.1 - 0.0081 15.7 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Immunity protein 28 ECSIT PF06239.6 ESS69297.1 - 0.021 13.7 0.1 0.026 13.3 0.1 1.2 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway Peptidase_C3 PF00548.15 ESS69297.1 - 0.026 14.3 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) Vasohibin PF14822.1 ESS69297.1 - 0.076 12.0 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Vasohibin WIYLD PF10440.4 ESS69297.1 - 0.088 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain HTH_33 PF13592.1 ESS69297.1 - 0.1 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Dynein_light PF01221.13 ESS69298.1 - 4.8e-37 125.8 1.1 5.2e-37 125.7 0.8 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 RRM_1 PF00076.17 ESS69299.1 - 1.8e-21 75.5 0.0 2.7e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69299.1 - 3.6e-15 55.7 0.1 7.9e-15 54.6 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69299.1 - 5.8e-12 45.2 0.0 8.7e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2475 PF10629.4 ESS69300.1 - 7.1e-05 22.9 0.9 0.00017 21.7 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2475) B9-C2 PF07162.6 ESS69301.1 - 4.1e-50 169.8 0.1 4.6e-50 169.6 0.1 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Condensation PF00668.15 ESS69304.1 - 0.017 13.9 0.4 0.02 13.7 0.3 1.1 1 0 0 1 1 1 0 Condensation domain N-SET PF11764.3 ESS69304.1 - 0.053 13.4 0.5 0.067 13.0 0.3 1.1 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component N Fcf2 PF08698.6 ESS69305.1 - 9.1e-21 73.7 1.1 9.1e-21 73.7 0.8 2.2 1 1 1 2 2 2 2 Fcf2 pre-rRNA processing Tombus_movement PF05318.7 ESS69305.1 - 1.3 9.6 6.3 5.2 7.7 1.1 2.5 2 0 0 2 2 2 0 Tombusvirus movement protein Bud13 PF09736.4 ESS69306.1 - 1.5e-06 28.5 1.1 5.8e-06 26.6 0.1 2.0 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex RRM_1 PF00076.17 ESS69307.1 - 4.8e-19 67.7 0.0 1.7e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69307.1 - 1.8e-11 43.8 0.0 5.3e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69307.1 - 4.4e-10 39.2 0.1 9.4e-10 38.1 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 ESS69328.1 - 2.7e-05 23.7 1.3 6.7e-05 22.4 0.9 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS69328.1 - 0.027 14.4 1.5 0.027 14.4 1.0 2.3 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type DUF3166 PF11365.3 ESS69328.1 - 0.13 12.7 0.3 2.9 8.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3166) RRM_5 PF13893.1 ESS69329.1 - 0.0097 15.7 0.1 0.025 14.4 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.18 ESS69331.1 - 9.1e-11 41.0 2.2 8.6e-06 24.6 0.0 3.1 3 0 0 3 3 3 2 Kinesin motor domain Mnd1 PF03962.10 ESS69331.1 - 0.00017 21.2 19.3 0.0047 16.6 7.9 2.4 2 0 0 2 2 2 2 Mnd1 family DUF1664 PF07889.7 ESS69331.1 - 0.32 10.8 11.8 0.088 12.6 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) IncA PF04156.9 ESS69331.1 - 0.98 8.9 28.9 0.72 9.4 9.9 3.2 1 1 2 3 3 3 0 IncA protein Sas10_Utp3 PF04000.10 ESS69331.1 - 1.2 9.3 5.4 4.8 7.4 0.0 4.0 4 1 1 5 5 5 0 Sas10/Utp3/C1D family Syntaxin PF00804.20 ESS69331.1 - 3.5 7.8 19.4 0.046 13.8 4.2 3.6 3 1 1 4 4 4 0 Syntaxin Phage_GP20 PF06810.6 ESS69331.1 - 8.6 5.7 16.7 0.24 10.8 3.0 2.6 2 1 1 3 3 3 0 Phage minor structural protein GP20 TPR_12 PF13424.1 ESS69332.1 - 1e-09 38.2 4.0 6e-09 35.7 0.1 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS69332.1 - 1.4e-05 24.6 2.5 3.3e-05 23.4 0.1 2.6 3 0 0 3 3 3 1 TPR repeat TPR_1 PF00515.23 ESS69332.1 - 5.2e-05 22.6 0.7 0.026 14.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESS69332.1 - 0.00011 21.9 9.4 0.00028 20.7 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS69332.1 - 0.029 14.2 4.4 0.029 14.2 0.0 3.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS69332.1 - 0.041 13.6 2.0 0.16 11.8 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69332.1 - 0.042 14.2 0.8 0.1 12.9 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NAD_kinase PF01513.16 ESS69333.1 - 2.1e-16 59.5 0.0 3.4e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 ESS69333.1 - 0.11 11.9 0.0 0.31 10.4 0.0 1.7 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Cnd2 PF05786.9 ESS69334.1 - 1.1e-24 87.0 0.0 2.2e-11 43.0 0.0 2.6 2 1 0 2 2 2 2 Condensin complex subunit 2 SpoU_methylase PF00588.14 ESS69337.1 - 1.7e-17 63.6 0.1 1.9e-15 56.9 0.0 2.6 2 1 0 2 2 2 2 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 ESS69337.1 - 1.7e-05 24.9 0.0 0.0027 17.8 0.0 2.4 2 0 0 2 2 2 2 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.2 ESS69338.1 - 2.2e-35 119.6 3.2 0.0011 18.5 0.0 10.7 9 1 1 10 10 10 9 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESS69338.1 - 7.9e-25 84.1 18.8 0.063 13.3 0.0 14.5 16 1 0 16 16 16 7 Leucine Rich repeat LRR_8 PF13855.1 ESS69338.1 - 4.8e-17 61.4 20.4 0.00074 19.2 0.4 9.3 5 2 4 10 10 10 6 Leucine rich repeat LRR_1 PF00560.28 ESS69338.1 - 1.2e-09 36.8 26.0 3.6 7.9 0.1 15.2 13 5 1 14 14 14 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS69338.1 - 0.001 18.8 36.6 32 5.3 0.1 14.8 18 1 0 18 18 18 0 Leucine rich repeat dUTPase_2 PF08761.6 ESS69343.1 - 4.6e-40 137.4 0.0 7.4e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 dUTPase DUF2767 PF10965.3 ESS69343.1 - 0.088 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2767) PHD PF00628.24 ESS69346.1 - 0.0075 15.9 4.9 0.0075 15.9 3.4 2.2 2 0 0 2 2 2 1 PHD-finger DUF89 PF01937.14 ESS69347.1 - 1.7e-37 129.0 0.0 9.4e-29 100.2 0.0 5.2 4 1 0 4 4 4 4 Protein of unknown function DUF89 Put_Phosphatase PF06888.7 ESS69347.1 - 1.4e-30 106.2 0.0 3.3e-30 104.9 0.0 1.6 1 1 0 1 1 1 1 Putative Phosphatase HAD PF12710.2 ESS69347.1 - 1.4e-07 31.8 0.0 4.1e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2175 PF09943.4 ESS69348.1 - 0.058 13.4 0.2 0.15 12.1 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Pkinase PF00069.20 ESS69350.1 - 7.9e-59 198.9 0.0 1.5e-58 198.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69350.1 - 1.4e-36 125.8 0.0 2.7e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 ESS69350.1 - 3e-07 30.4 0.6 1e-06 28.7 0.2 2.2 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.1 ESS69350.1 - 0.0006 18.8 0.0 0.0014 17.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like PAS PF00989.19 ESS69350.1 - 0.043 13.6 0.0 1.7 8.4 0.0 3.0 3 0 0 3 3 3 0 PAS fold Prenyltrans PF00432.16 ESS69351.1 - 8.7e-29 98.7 4.2 4.4e-09 35.7 0.2 6.1 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESS69351.1 - 9.2e-25 87.2 0.0 1.1e-10 41.8 0.0 5.6 4 2 1 5 5 5 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESS69351.1 - 1.5e-20 73.2 1.0 1.6e-05 24.8 0.1 5.7 4 1 2 7 7 7 5 Prenyltransferase-like Pec_lyase PF09492.5 ESS69351.1 - 1.1e-07 31.3 0.0 0.66 9.0 0.0 4.4 4 1 0 4 4 4 3 Pectic acid lyase TPR_11 PF13414.1 ESS69354.1 - 4.8e-06 26.1 0.1 1.1e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 TPR repeat TPR_9 PF13371.1 ESS69354.1 - 0.00039 20.2 1.3 0.00096 18.9 0.9 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat YEATS PF03366.11 ESS69356.1 - 3.3e-20 71.5 0.1 7.1e-20 70.5 0.1 1.5 1 0 0 1 1 1 1 YEATS family PALP PF00291.20 ESS69357.1 - 1.8e-44 152.2 1.4 2.1e-44 151.9 1.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TPR_2 PF07719.12 ESS69361.1 - 0.00053 19.7 1.4 0.69 9.9 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS69361.1 - 0.0079 15.8 0.5 0.2 11.3 0.2 2.4 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 ESS69361.1 - 0.0088 15.6 0.9 2 8.1 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69361.1 - 0.12 12.7 0.2 14 6.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS69361.1 - 0.17 11.8 1.0 5.7 6.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Ly49 PF08391.5 ESS69362.1 - 0.51 10.4 3.6 8.7 6.5 0.1 2.5 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region HlyIII PF03006.15 ESS69363.1 - 1.3e-22 80.2 17.7 1.7e-22 79.9 12.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF164 PF02591.10 ESS69364.1 - 0.063 13.1 0.4 0.31 10.9 0.0 2.3 2 0 0 2 2 2 0 Putative zinc ribbon domain RRM_1 PF00076.17 ESS69365.1 - 7.7e-30 102.3 0.0 3.4e-14 52.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69365.1 - 3.2e-21 75.0 0.0 5.8e-10 38.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69365.1 - 1.7e-14 53.3 0.0 5.5e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.6 ESS69368.1 - 0.00012 22.4 0.1 0.00026 21.3 0.1 1.4 1 0 0 1 1 1 1 Glycine rich protein family DUF1191 PF06697.7 ESS69368.1 - 0.013 14.3 0.0 0.025 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) CcmD PF04995.9 ESS69368.1 - 0.033 13.9 0.2 0.033 13.9 0.1 1.6 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DUF3481 PF11980.3 ESS69368.1 - 0.063 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) DUF4529 PF15032.1 ESS69370.1 - 0.0027 16.3 0.1 0.0037 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4529) SNARE PF05739.14 ESS69372.1 - 0.00026 20.6 0.3 0.00026 20.6 0.2 2.5 2 0 0 2 2 2 1 SNARE domain Herpes_UL56 PF04534.7 ESS69372.1 - 0.043 13.5 2.2 0.084 12.5 1.5 1.4 1 0 0 1 1 1 0 Herpesvirus UL56 protein Snapin_Pallidin PF14712.1 ESS69372.1 - 0.22 11.8 0.2 0.22 11.8 0.1 1.8 2 0 0 2 2 2 0 Snapin/Pallidin LNS2 PF08235.8 ESS69373.1 - 9.9e-58 194.1 0.0 1.6e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 ESS69373.1 - 1.4e-22 79.4 0.0 3.6e-22 78.1 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.9 ESS69373.1 - 0.014 14.7 0.0 0.046 13.0 0.0 1.8 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) AF1Q PF15017.1 ESS69373.1 - 0.019 14.8 0.8 0.074 12.9 0.0 2.4 2 0 0 2 2 2 0 Drug resistance and apoptosis regulator EF-hand_1 PF00036.27 ESS69375.1 - 0.006 15.8 0.0 0.016 14.4 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 ESS69375.1 - 0.0062 16.6 0.0 0.021 14.9 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS69375.1 - 0.016 15.0 0.0 0.052 13.4 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain ABA_GPCR PF12430.3 ESS69375.1 - 0.032 13.3 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor Thymidylat_synt PF00303.14 ESS69376.1 - 3e-112 374.0 0.0 4.1e-112 373.5 0.0 1.2 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.14 ESS69376.1 - 5.3e-23 81.3 0.0 5.5e-22 78.0 0.0 2.4 1 1 0 1 1 1 1 Dihydrofolate reductase PrmA PF06325.8 ESS69377.1 - 1.9e-11 43.6 0.0 3e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 ESS69377.1 - 1.1e-10 42.1 0.0 2.2e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS69377.1 - 2.4e-06 27.2 0.0 4.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS69377.1 - 5.1e-06 25.9 0.0 9.1e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.11 ESS69377.1 - 8e-06 25.0 0.0 1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_26 PF13659.1 ESS69377.1 - 1.4e-05 25.0 0.0 2.8e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 ESS69377.1 - 1.4e-05 24.7 0.0 2.6e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_16 PF10294.4 ESS69377.1 - 2.2e-05 24.0 0.0 3.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.14 ESS69377.1 - 5e-05 22.9 0.1 0.00012 21.7 0.0 1.5 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.10 ESS69377.1 - 0.00028 20.3 0.0 0.00054 19.4 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.15 ESS69377.1 - 0.00053 19.1 0.0 0.00088 18.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_11 PF08241.7 ESS69377.1 - 0.0025 18.2 0.0 0.0071 16.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS69377.1 - 0.014 15.1 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 ESS69377.1 - 0.024 13.7 0.0 0.037 13.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TLD PF07534.11 ESS69378.1 - 1.2e-15 57.7 0.0 1.9e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 TLD Orexin PF02072.10 ESS69378.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Prepro-orexin Borrelia_lipo_1 PF05714.6 ESS69379.1 - 0.19 10.7 0.3 1.1 8.3 0.0 1.9 2 0 0 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein PP2C PF00481.16 ESS69382.1 - 8.7e-31 107.2 0.0 3.2e-28 98.8 0.0 3.0 1 1 0 1 1 1 1 Protein phosphatase 2C Oxidored_FMN PF00724.15 ESS69384.1 - 8.7e-43 146.6 0.0 1.4e-42 145.9 0.0 1.3 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.9 ESS69384.1 - 1.8e-12 47.5 0.0 3.9e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS69384.1 - 1.6e-09 37.6 0.0 9.4e-09 35.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESS69384.1 - 4.6e-09 35.6 0.0 6.7e-08 31.8 0.0 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESS69384.1 - 2.7e-08 34.1 0.1 0.0018 18.3 0.1 2.6 1 1 2 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ESS69384.1 - 3.7e-07 28.9 0.1 1.4e-06 27.0 0.0 2.0 1 1 1 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 ESS69384.1 - 4.2e-07 29.1 0.1 1.1e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.2 ESS69384.1 - 9.8e-07 28.1 0.0 1.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESS69384.1 - 1.2e-06 28.8 0.2 0.0016 18.8 0.1 3.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS69384.1 - 0.00047 19.1 0.2 0.00073 18.5 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.12 ESS69384.1 - 0.00083 18.5 0.0 0.0017 17.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Amino_oxidase PF01593.19 ESS69384.1 - 0.001 18.2 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase 3HCDH_N PF02737.13 ESS69384.1 - 0.0014 18.3 0.1 0.013 15.1 0.1 2.5 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FMO-like PF00743.14 ESS69384.1 - 0.002 16.4 0.1 0.062 11.4 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like ApbA PF02558.11 ESS69384.1 - 0.0023 17.4 0.1 0.012 15.0 0.0 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 ESS69384.1 - 0.014 15.1 0.1 0.038 13.7 0.1 1.8 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 ESS69384.1 - 0.018 14.1 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.15 ESS69384.1 - 0.02 14.9 0.0 5.6 7.0 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 ESS69384.1 - 0.023 14.4 0.6 0.072 12.8 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding UDPG_MGDP_dh_N PF03721.9 ESS69384.1 - 0.024 14.0 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_10 PF13460.1 ESS69384.1 - 0.027 14.4 1.0 0.14 12.1 0.1 2.6 3 0 0 3 3 3 0 NADH(P)-binding NAD_binding_7 PF13241.1 ESS69384.1 - 0.039 14.1 0.0 0.75 10.0 0.0 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.9 ESS69384.1 - 0.052 12.1 0.0 0.083 11.5 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase K_oxygenase PF13434.1 ESS69384.1 - 0.056 12.3 0.0 5 5.9 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_2 PF03446.10 ESS69384.1 - 0.081 12.7 0.1 0.9 9.3 0.0 2.6 3 0 0 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.16 ESS69384.1 - 0.11 12.3 1.1 2.1 8.1 0.0 2.8 3 0 0 3 3 3 0 ThiF family TLD PF07534.11 ESS69385.1 - 2.3e-12 47.1 0.0 8.2e-07 29.0 0.0 3.3 3 1 0 3 3 3 2 TLD DUF1954 PF09199.5 ESS69385.1 - 0.17 12.0 0.1 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1954) SIS PF01380.17 ESS69386.1 - 1.2e-53 180.2 0.2 9e-27 93.2 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 ESS69386.1 - 8.9e-22 77.2 0.1 3.2e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 ESS69386.1 - 6.9e-18 64.8 0.0 2.7e-17 62.9 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.1 ESS69386.1 - 2.9e-10 39.9 0.0 9e-10 38.3 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 ESS69386.1 - 3.8e-09 35.6 0.1 2.4e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 ESS69386.1 - 0.00013 21.7 0.4 0.0012 18.5 0.0 2.6 3 0 0 3 3 3 1 SIS domain OspD PF03207.8 ESS69386.1 - 0.062 12.4 1.4 0.12 11.4 1.0 1.4 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) Tmemb_161AB PF10268.4 ESS69386.1 - 0.096 11.1 0.3 0.43 9.0 0.0 1.9 2 0 0 2 2 2 0 Predicted transmembrane protein 161AB Kdo_hydroxy PF11004.3 ESS69387.1 - 0.015 14.3 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase DUF3883 PF13020.1 ESS69388.1 - 3.4e-18 65.1 0.0 6.2e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) LRR_4 PF12799.2 ESS69389.1 - 7.5e-24 82.8 3.6 0.00026 20.5 0.1 6.1 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS69389.1 - 1.8e-18 66.0 8.5 3.5e-06 26.6 0.6 4.2 3 1 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 ESS69389.1 - 1.5e-08 33.5 13.3 5.5 7.4 0.0 9.8 9 1 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS69389.1 - 5.8e-05 22.7 9.3 4 7.7 0.0 7.4 7 1 0 7 7 7 1 Leucine Rich repeat LRR_7 PF13504.1 ESS69389.1 - 0.0001 21.8 9.5 42 4.9 0.1 8.4 9 0 0 9 9 9 0 Leucine rich repeat DUF1399 PF07173.7 ESS69389.1 - 0.012 15.8 1.1 0.41 10.9 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1399) WD40 PF00400.27 ESS69391.1 - 1.4e-05 24.8 0.2 0.00035 20.3 0.0 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat SET PF00856.23 ESS69392.1 - 1.6e-10 41.5 0.1 1.8e-08 34.8 0.0 2.3 2 0 0 2 2 2 2 SET domain zf-MYND PF01753.13 ESS69392.1 - 0.0003 20.6 13.8 0.0003 20.6 9.6 2.2 2 0 0 2 2 2 1 MYND finger TPR_14 PF13428.1 ESS69392.1 - 0.032 14.8 0.4 0.17 12.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Kinesin PF00225.18 ESS69394.1 - 4.5e-79 265.5 0.1 7.1e-79 264.9 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain IncA PF04156.9 ESS69394.1 - 1.2e-05 24.9 5.1 2e-05 24.2 0.9 2.3 2 0 0 2 2 2 1 IncA protein DUF972 PF06156.8 ESS69394.1 - 0.018 15.3 4.1 0.088 13.1 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Leu_zip PF15294.1 ESS69394.1 - 0.1 11.6 6.0 0.39 9.7 0.5 2.4 2 0 0 2 2 2 0 Leucine zipper DUF87 PF01935.12 ESS69394.1 - 2.7 7.7 4.4 8.4 6.1 0.3 2.9 2 1 1 3 3 3 0 Domain of unknown function DUF87 KLRAQ PF10205.4 ESS69394.1 - 4.2 7.4 10.9 0.25 11.4 3.2 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein QRPTase_C PF01729.14 ESS69396.1 - 0.0043 16.5 0.1 0.013 15.0 0.0 1.8 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Gluconate_2-dh3 PF13618.1 ESS69396.1 - 0.14 12.3 1.4 0.67 10.0 1.0 2.3 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 APC_CDC26 PF10471.4 ESS69396.1 - 2.2 9.1 11.1 15 6.3 0.3 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 TPD52 PF04201.10 ESS69397.1 - 0.011 15.4 0.8 0.011 15.4 0.5 2.4 2 2 0 2 2 2 0 Tumour protein D52 family SIP PF04954.8 ESS69397.1 - 1.7 9.0 9.4 0.12 12.7 1.0 2.9 2 1 0 2 2 2 0 Siderophore-interacting protein Syntaxin-6_N PF09177.6 ESS69398.1 - 0.0043 17.4 3.4 0.0043 17.4 2.3 5.9 4 2 1 6 6 6 1 Syntaxin 6, N-terminal DUF948 PF06103.6 ESS69398.1 - 2 8.3 6.8 8 6.4 0.2 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.7 ESS69398.1 - 2.5 8.4 13.7 2.1 8.6 0.4 5.0 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.7 ESS69398.1 - 5.2 6.8 31.1 0.034 13.9 1.2 4.7 4 1 1 5 5 5 0 Laminin Domain II DUF1664 PF07889.7 ESS69398.1 - 9.1 6.1 13.6 5.3 6.8 1.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Peptidase_M8 PF01457.11 ESS69399.1 - 9.7e-49 166.0 0.0 1.2e-48 165.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M57 PF12388.3 ESS69399.1 - 0.039 13.2 0.0 0.069 12.4 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.19 ESS69399.1 - 0.061 12.7 0.2 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) HEAT PF02985.17 ESS69401.1 - 0.17 12.0 0.3 0.77 9.9 0.0 2.2 2 0 0 2 2 2 0 HEAT repeat WD40 PF00400.27 ESS69402.1 - 0.00033 20.4 0.2 0.0039 17.0 0.1 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat FHA PF00498.21 ESS69403.1 - 8.4e-05 22.6 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain DUF4379 PF14311.1 ESS69404.1 - 1e-33 114.9 20.1 2.8e-11 43.0 0.1 4.7 4 0 0 4 4 4 4 Domain of unknown function (DUF4379) Synapsin PF02078.11 ESS69405.1 - 0.071 13.2 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 Synapsin, N-terminal domain PhoU_div PF01865.11 ESS69405.1 - 0.16 11.1 0.6 0.48 9.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF47 Pkinase PF00069.20 ESS69406.1 - 3.2e-57 193.6 0.0 3.1e-56 190.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69406.1 - 8e-34 116.8 0.3 1.3e-24 86.7 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS69406.1 - 1.6e-05 24.7 0.0 0.0085 15.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS69406.1 - 0.00063 18.7 0.0 0.0021 17.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pox_ser-thr_kin PF05445.6 ESS69406.1 - 0.024 13.4 0.0 0.037 12.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 ESS69406.1 - 0.065 12.2 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1637 PF07847.7 ESS69407.1 - 1e-46 158.8 0.0 1.2e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1637) CDO_I PF05995.7 ESS69407.1 - 0.0036 16.4 0.0 0.013 14.6 0.0 1.8 1 1 0 1 1 1 1 Cysteine dioxygenase type I Cupin_2 PF07883.6 ESS69407.1 - 0.086 12.3 0.4 7.1 6.2 0.0 2.5 2 1 0 2 2 2 0 Cupin domain LSR PF05624.9 ESS69408.1 - 0.75 9.5 6.0 1.3 8.7 4.2 1.4 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) Peptidase_C1 PF00112.18 ESS69409.1 - 6e-35 121.1 0.1 8.6e-35 120.5 0.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 ESS69409.1 - 1.8e-16 60.1 0.5 3.5e-16 59.2 0.1 1.6 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) FAD_binding_3 PF01494.14 ESS69410.1 - 1.7e-09 37.2 0.1 5e-09 35.6 0.0 1.9 2 1 0 2 2 2 1 FAD binding domain SE PF08491.5 ESS69410.1 - 0.0079 15.0 0.0 0.014 14.2 0.0 1.6 1 1 0 1 1 1 1 Squalene epoxidase Prenyltransf PF01255.14 ESS69412.1 - 4.6e-51 173.0 0.0 5.9e-49 166.1 0.0 2.1 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase WD40 PF00400.27 ESS69413.1 - 3.2e-14 52.1 17.6 1.6e-05 24.5 0.2 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat PQQ_2 PF13360.1 ESS69413.1 - 0.0021 17.5 0.0 0.004 16.6 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain DUF3874 PF12990.2 ESS69413.1 - 0.094 12.8 0.0 0.4 10.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknonw function from B. Theta Gene description (DUF3874) DUF1930 PF09122.5 ESS69414.1 - 1.6e-37 127.1 0.1 2.8e-37 126.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1930) Rhodanese PF00581.15 ESS69414.1 - 5.1e-25 88.0 0.0 2.2e-13 50.5 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain NOA36 PF06524.7 ESS69415.1 - 0.023 13.9 1.2 0.034 13.4 0.9 1.3 1 0 0 1 1 1 0 NOA36 protein Acyl-CoA_dh_1 PF00441.19 ESS69416.1 - 4.5e-52 176.1 2.4 7e-52 175.5 1.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESS69416.1 - 3.8e-27 95.1 0.0 1e-26 93.7 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESS69416.1 - 6.6e-21 73.5 0.1 1.2e-20 72.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESS69416.1 - 5.6e-20 71.9 1.5 5.6e-20 71.9 1.0 1.5 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 ESS69416.1 - 0.013 14.8 2.6 0.028 13.8 0.5 2.2 2 1 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Ctf8 PF09696.5 ESS69417.1 - 2.9e-09 36.7 0.0 3.9e-08 33.0 0.0 2.2 1 1 0 1 1 1 1 Ctf8 DUF507 PF04368.8 ESS69418.1 - 0.0029 17.2 0.0 0.0046 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF507) G-patch PF01585.18 ESS69419.1 - 2.4e-11 43.2 2.3 3.9e-11 42.5 1.6 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESS69419.1 - 1.5e-05 24.7 1.0 3.8e-05 23.4 0.7 1.7 1 0 0 1 1 1 1 DExH-box splicing factor binding site Cmc1 PF08583.5 ESS69420.1 - 8.1e-07 28.7 3.5 1.7e-06 27.7 2.4 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.8 ESS69420.1 - 0.00023 20.4 3.2 0.00046 19.5 2.2 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.4 ESS69420.1 - 0.089 12.8 2.6 0.18 11.8 1.8 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 IpaC_SipC PF09599.5 ESS69420.1 - 0.34 9.9 2.3 0.44 9.5 1.6 1.2 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) CHCH PF06747.8 ESS69420.1 - 0.5 10.3 4.6 0.89 9.5 3.2 1.5 1 0 0 1 1 1 0 CHCH domain XH PF03469.9 ESS69420.1 - 0.98 9.0 6.7 0.25 10.9 1.6 2.0 1 1 0 2 2 2 0 XH domain Ank_2 PF12796.2 ESS69421.1 - 1.1e-12 48.0 0.0 2.5e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS69421.1 - 3.5e-12 46.1 2.9 4e-05 23.7 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 ESS69421.1 - 1.2e-11 43.8 0.1 1.6e-05 24.4 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat C2 PF00168.25 ESS69421.1 - 5.6e-11 42.1 0.0 1.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ank_4 PF13637.1 ESS69421.1 - 8.4e-11 42.0 0.5 9.2e-05 22.8 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS69421.1 - 2.8e-09 36.2 0.0 0.0055 16.8 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat F-box-like PF12937.2 ESS69446.1 - 1.7e-06 27.6 0.9 3.4e-06 26.6 0.2 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESS69446.1 - 0.00035 20.1 0.1 0.00075 19.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain DHC_N2 PF08393.8 ESS69447.1 - 2e-38 131.9 2.6 3.5e-38 131.1 1.8 1.3 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 ABC_tran PF00005.22 ESS69448.1 - 0.00012 22.3 0.0 0.0027 17.9 0.0 2.8 2 0 0 2 2 2 1 ABC transporter Sigma54_activ_2 PF14532.1 ESS69448.1 - 0.0002 21.3 0.0 0.12 12.3 0.0 3.0 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.1 ESS69448.1 - 0.00022 21.2 0.1 0.021 14.8 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.1 ESS69448.1 - 0.00066 19.1 0.1 0.0067 15.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_7 PF12775.2 ESS69448.1 - 0.0016 17.6 0.0 0.0087 15.1 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_22 PF13401.1 ESS69448.1 - 0.0025 17.9 0.1 0.12 12.5 0.0 3.7 3 0 0 3 3 2 1 AAA domain Arch_ATPase PF01637.13 ESS69448.1 - 0.014 15.1 0.1 3 7.4 0.0 3.1 3 0 0 3 3 3 0 Archaeal ATPase Sigma54_activat PF00158.21 ESS69448.1 - 0.017 14.6 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_23 PF13476.1 ESS69448.1 - 0.025 14.8 0.0 0.025 14.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.15 ESS69448.1 - 0.026 13.2 0.5 0.41 9.2 0.0 2.7 3 0 0 3 3 3 0 G-protein alpha subunit AAA_15 PF13175.1 ESS69448.1 - 0.029 13.4 0.0 0.28 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 ESS69448.1 - 0.063 12.7 0.1 2.9 7.3 0.0 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family UPF0079 PF02367.12 ESS69448.1 - 0.079 12.5 0.0 6.9 6.3 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Ribosomal_L7Ae PF01248.21 ESS69451.1 - 2e-20 72.0 0.4 3.6e-20 71.2 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PT PF04886.7 ESS69451.1 - 6.3e-05 22.2 7.8 0.0092 15.2 2.3 2.3 1 1 1 2 2 2 2 PT repeat RNase_P_pop3 PF08228.6 ESS69451.1 - 7.6e-05 22.6 0.1 0.00012 21.9 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 MAM1 PF10434.4 ESS69451.1 - 0.034 13.3 0.5 0.05 12.8 0.3 1.2 1 0 0 1 1 1 0 Monopolin complex protein MAM1 DUF4106 PF13388.1 ESS69451.1 - 0.75 8.6 8.9 1.2 8.0 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Mito_carr PF00153.22 ESS69452.1 - 2e-37 126.8 0.4 3e-15 55.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Brucella_OMP2 PF05244.6 ESS69455.1 - 0.094 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Brucella outer membrane protein 2 RCR PF12273.3 ESS69457.1 - 0.2 12.2 0.1 0.2 12.2 0.1 3.2 3 0 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red DUF4230 PF14014.1 ESS69458.1 - 0.13 12.1 0.0 0.13 12.1 0.0 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF4230) eIF-3c_N PF05470.7 ESS69459.1 - 0.33 9.0 2.9 0.38 8.7 2.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Nop53 PF07767.6 ESS69459.1 - 0.35 9.8 5.9 0.51 9.2 4.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF4175 PF13779.1 ESS69459.1 - 2.9 5.4 8.4 3.8 5.0 5.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CDC45 PF02724.9 ESS69459.1 - 8.8 4.2 6.3 11 3.8 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein MobB PF03205.9 ESS69460.1 - 3.1e-08 33.4 0.0 7.4e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Clp1 PF06807.9 ESS69460.1 - 0.011 15.5 0.0 0.07 12.8 0.0 2.1 2 0 0 2 2 2 0 Pre-mRNA cleavage complex II protein Clp1 Arch_ATPase PF01637.13 ESS69460.1 - 0.05 13.2 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AD PF09793.4 ESS69460.1 - 0.16 11.7 0.1 0.55 10.1 0.0 1.8 2 0 0 2 2 2 0 Anticodon-binding domain Sel1 PF08238.7 ESS69461.1 - 6.4e-20 71.1 34.2 0.0037 17.8 0.0 9.4 10 0 0 10 10 10 7 Sel1 repeat DAO PF01266.19 ESS69462.1 - 5.3e-11 42.0 0.2 3.2e-05 22.9 0.7 2.1 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESS69462.1 - 1e-06 28.6 0.5 2.7e-06 27.2 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESS69462.1 - 1.7e-06 28.0 0.0 3.3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESS69462.1 - 1.8e-05 23.7 1.3 0.00015 20.7 0.9 2.2 3 0 0 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.7 ESS69462.1 - 6.6e-05 22.0 0.4 9.9e-05 21.4 0.0 1.4 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.9 ESS69462.1 - 0.00011 20.8 0.1 0.00023 19.7 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.1 ESS69462.1 - 0.00026 20.7 0.1 0.00051 19.8 0.1 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.12 ESS69462.1 - 0.00035 19.7 0.1 0.00063 18.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 ESS69462.1 - 0.0019 17.3 0.1 0.0037 16.3 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 ESS69462.1 - 0.0031 17.6 0.3 0.0059 16.6 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ESS69462.1 - 0.0043 16.1 0.4 0.0072 15.4 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 ESS69462.1 - 0.0094 14.6 0.1 0.019 13.6 0.1 1.5 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox PF00070.22 ESS69462.1 - 0.019 15.3 0.0 0.66 10.4 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESS69462.1 - 0.042 12.7 0.4 0.077 11.8 0.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NPV_P10 PF05531.7 ESS69463.1 - 0.0096 16.1 13.2 0.5 10.6 0.1 4.7 5 2 0 5 5 5 2 Nucleopolyhedrovirus P10 protein FliD_C PF07195.7 ESS69463.1 - 0.03 13.6 0.5 0.12 11.7 0.3 2.0 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF3510 PF12022.3 ESS69463.1 - 0.17 12.0 6.5 4.6 7.3 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3510) DUF2746 PF10874.3 ESS69463.1 - 1 9.5 5.4 7.6 6.8 0.2 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) Rnk_N PF14760.1 ESS69463.1 - 1.9 8.6 11.1 6.7 6.8 0.1 4.9 5 0 0 5 5 5 0 Rnk N-terminus DUF3287 PF11690.3 ESS69463.1 - 2 8.4 6.9 0.64 10.1 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) Flu_NS2 PF00601.14 ESS69463.1 - 2.8 8.2 14.0 18 5.5 0.1 4.7 4 0 0 4 4 4 0 Influenza non-structural protein (NS2) RmuC PF02646.11 ESS69463.1 - 4.9 5.9 19.1 0.22 10.3 1.1 3.4 3 1 0 3 3 3 0 RmuC family E1-E2_ATPase PF00122.15 ESS69465.1 - 5.8e-51 172.7 0.7 5.8e-51 172.7 0.5 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESS69465.1 - 3.2e-40 137.6 4.2 6.6e-40 136.5 2.9 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESS69465.1 - 1.2e-22 81.4 0.0 1e-21 78.3 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESS69465.1 - 4e-14 51.8 0.0 8.3e-14 50.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 ESS69465.1 - 1.8e-10 40.5 0.0 4.2e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESS69465.1 - 2.1e-09 37.8 0.0 8.9e-09 35.7 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESS69465.1 - 4.4e-05 23.1 0.1 0.0016 18.0 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3484 PF11983.3 ESS69466.1 - 0.066 14.0 1.1 0.066 14.0 0.7 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF3484) V_ATPase_I PF01496.14 ESS69466.1 - 0.1 10.4 12.6 0.12 10.1 8.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF148 PF02520.12 ESS69466.1 - 0.17 11.6 12.9 0.056 13.2 1.8 2.7 1 1 0 2 2 2 0 Domain of unknown function DUF148 Jnk-SapK_ap_N PF09744.4 ESS69466.1 - 1 9.3 25.6 0.066 13.1 10.0 2.6 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 NPV_P10 PF05531.7 ESS69466.1 - 3.1 8.1 11.5 45 4.3 2.9 3.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Metallophos PF00149.23 ESS69468.1 - 4.5e-21 75.1 0.1 7.7e-21 74.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DM PF00751.13 ESS69468.1 - 0.032 13.7 5.6 0.074 12.5 3.9 1.6 1 0 0 1 1 1 0 DM DNA binding domain EF-hand_6 PF13405.1 ESS69468.1 - 0.15 12.0 0.1 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain zf-TAZ PF02135.11 ESS69468.1 - 1.1 9.2 9.3 1.9 8.5 5.6 1.9 2 0 0 2 2 2 0 TAZ zinc finger Pkinase PF00069.20 ESS69469.1 - 9.5e-42 142.9 0.0 1e-14 54.3 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69469.1 - 1.2e-23 83.4 0.0 4.6e-16 58.6 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.18 ESS69469.1 - 0.0039 16.9 0.0 2 8.0 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family PAP_assoc PF03828.14 ESS69470.1 - 5.1e-12 45.5 0.0 1.1e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESS69470.1 - 1.4e-07 31.7 0.0 3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Vps39_2 PF10367.4 ESS69472.1 - 0.00063 19.8 0.1 0.0016 18.6 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.1 ESS69472.1 - 0.0099 15.6 2.2 0.0099 15.6 1.5 2.4 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.24 ESS69472.1 - 0.072 12.7 1.5 0.21 11.2 1.0 1.8 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_2 PF13923.1 ESS69472.1 - 0.16 12.0 1.7 0.71 9.9 1.2 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MCD PF05292.6 ESS69473.1 - 1.4e-57 195.0 0.1 1.3e-33 116.1 0.0 3.3 2 1 0 2 2 2 2 Malonyl-CoA decarboxylase (MCD) Hemocyanin_M PF00372.14 ESS69473.1 - 0.029 13.6 5.1 1 8.5 0.2 2.9 3 0 0 3 3 3 0 Hemocyanin, copper containing domain WD40 PF00400.27 ESS69474.1 - 0.00012 21.7 11.7 0.1 12.5 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat EF-hand_6 PF13405.1 ESS69474.1 - 0.0037 17.0 0.1 0.028 14.3 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain Col_cuticle_N PF01484.12 ESS69476.1 - 0.35 10.5 0.2 0.35 10.5 0.2 3.5 3 1 1 4 4 4 0 Nematode cuticle collagen N-terminal domain Pkinase PF00069.20 ESS69477.1 - 3.3e-41 141.1 0.0 7.9e-41 139.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69477.1 - 4.3e-20 71.8 0.0 5.2e-19 68.3 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase WEMBL PF05701.6 ESS69478.1 - 0.1 11.0 13.8 0.063 11.7 0.6 2.3 2 0 0 2 2 2 0 Weak chloroplast movement under blue light UreF PF01730.11 ESS69478.1 - 0.17 11.9 1.9 0.35 10.9 1.3 1.5 1 0 0 1 1 1 0 UreF RasGAP_C PF03836.10 ESS69478.1 - 0.29 10.8 2.9 0.6 9.7 2.0 1.6 1 0 0 1 1 1 0 RasGAP C-terminus Cortex-I_coil PF09304.5 ESS69478.1 - 3.4 7.7 9.1 14 5.7 0.2 2.7 3 0 0 3 3 3 0 Cortexillin I, coiled coil AAA_28 PF13521.1 ESS69479.1 - 4.1e-22 78.8 0.0 7e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESS69479.1 - 0.0095 15.1 0.0 0.021 14.0 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DAP3 PF10236.4 ESS69479.1 - 0.058 12.3 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mucin PF01456.12 ESS69479.1 - 4.9 6.9 14.6 0.94 9.2 1.7 3.6 4 0 0 4 4 4 0 Mucin-like glycoprotein DnaJ PF00226.26 ESS69480.1 - 1.6e-05 24.5 0.0 4e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain YqzM PF14141.1 ESS69480.1 - 0.0038 16.9 0.7 0.007 16.1 0.5 1.3 1 0 0 1 1 1 1 YqzM-like protein DUF1469 PF07332.6 ESS69480.1 - 0.028 14.1 0.5 0.053 13.2 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) 6PF2K PF01591.13 ESS69481.1 - 1.2e-21 76.8 0.9 2e-11 43.4 0.0 3.2 3 0 0 3 3 3 3 6-phosphofructo-2-kinase AAA_33 PF13671.1 ESS69481.1 - 0.00012 21.9 0.1 0.0007 19.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS69481.1 - 0.0016 19.2 0.0 0.0068 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain DnaJ PF00226.26 ESS69482.1 - 1.9e-08 33.9 0.0 4e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 ESS69482.1 - 0.029 14.1 1.4 0.11 12.3 0.0 2.4 3 0 0 3 3 3 0 Pam16 RRM_1 PF00076.17 ESS69484.1 - 1.1e-08 34.5 0.0 2.1e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69484.1 - 1.4e-05 24.9 0.0 2.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Mito_fiss_reg PF05308.6 ESS69484.1 - 3.8 6.7 10.9 0.054 12.8 1.8 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator Pol_alpha_B_N PF08418.5 ESS69484.1 - 4.3 6.8 6.8 7.8 5.9 4.7 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal PGM_PMM_I PF02878.11 ESS69485.1 - 6.3e-14 51.6 0.0 4.7e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.15 ESS69485.1 - 2.5e-08 33.7 0.0 7.7e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.11 ESS69485.1 - 2.2e-06 27.9 0.0 8.3e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 ESS69485.1 - 0.0004 20.3 0.0 0.0014 18.6 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Glycophorin_A PF01102.13 ESS69488.1 - 0.0028 17.4 0.2 0.0067 16.1 0.2 1.6 1 0 0 1 1 1 1 Glycophorin A TMEM154 PF15102.1 ESS69488.1 - 0.0068 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family DUF1191 PF06697.7 ESS69488.1 - 0.0099 14.7 0.0 0.017 13.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) DUF1180 PF06679.7 ESS69488.1 - 0.01 15.7 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Protocadherin PF08374.6 ESS69488.1 - 0.055 13.1 0.3 0.1 12.2 0.2 1.3 1 0 0 1 1 1 0 Protocadherin Herpes_gE PF02480.11 ESS69488.1 - 0.082 11.1 0.0 0.13 10.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.1 ESS69488.1 - 0.12 12.7 0.4 0.25 11.7 0.3 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.1 ESS69488.1 - 0.17 12.0 0.1 0.17 12.0 0.1 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Trypan_PARP PF05887.6 ESS69489.1 - 3 7.6 16.1 0.051 13.3 3.8 2.8 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) RRM_5 PF13893.1 ESS69490.1 - 3.5e-10 39.5 0.0 6.5e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS69490.1 - 1.1e-07 31.3 0.0 0.0023 17.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69490.1 - 2.8e-05 24.0 0.0 0.16 11.9 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF2361 PF10153.4 ESS69491.1 - 0.014 15.6 1.9 0.016 15.3 1.3 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2361) Anillin PF08174.6 ESS69491.1 - 1.9 8.5 5.7 11 6.0 4.0 1.9 1 1 0 1 1 1 0 Cell division protein anillin Pkinase PF00069.20 ESS69492.1 - 7.8e-57 192.3 0.0 1.1e-56 191.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69492.1 - 2.9e-39 134.7 0.0 6.1e-39 133.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69492.1 - 0.0017 17.3 0.0 0.003 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PX PF00787.19 ESS69492.1 - 0.059 13.1 0.0 0.23 11.2 0.1 1.9 2 0 0 2 2 2 0 PX domain ACR_tran PF00873.14 ESS69493.1 - 0.14 9.5 3.4 0.2 9.0 2.3 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family PA26 PF04636.8 ESS69493.1 - 3.3 6.2 6.1 6.4 5.3 4.2 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pkinase PF00069.20 ESS69494.1 - 8e-78 261.1 0.0 9.4e-78 260.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69494.1 - 4.5e-41 140.6 0.0 5.6e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69494.1 - 9.3e-08 31.3 0.0 3.3e-07 29.5 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESS69494.1 - 0.00042 19.4 0.2 0.00068 18.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESS69494.1 - 0.00058 19.2 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESS69494.1 - 0.0036 17.0 0.4 0.42 10.3 0.1 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF563 PF04577.9 ESS69496.1 - 1.2e-06 28.5 0.0 2.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF1422 PF07226.6 ESS69496.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1422) PKD_channel PF08016.7 ESS69498.1 - 1.4e-06 26.9 11.6 2.7e-06 26.0 8.1 1.4 1 0 0 1 1 1 1 Polycystin cation channel Microtub_assoc PF07989.6 ESS69499.1 - 0.022 14.5 0.6 0.046 13.5 0.4 1.6 1 0 0 1 1 1 0 Microtubule associated IncA PF04156.9 ESS69499.1 - 0.56 9.7 4.5 0.84 9.1 3.1 1.3 1 0 0 1 1 1 0 IncA protein WD40 PF00400.27 ESS69500.1 - 5.1e-12 45.1 0.7 0.00088 19.0 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat DUF3608 PF12257.3 ESS69502.1 - 3.2e-19 68.9 1.0 6.6e-16 58.0 0.3 3.1 2 1 0 2 2 2 2 Protein of unknown function (DUF3608) VID27 PF08553.5 ESS69504.1 - 1.8e-18 66.1 0.0 3.3e-18 65.3 0.0 1.3 1 1 0 1 1 1 1 VID27 cytoplasmic protein HEAT_EZ PF13513.1 ESS69507.1 - 0.071 13.6 0.5 12 6.5 0.0 2.9 2 0 0 2 2 2 0 HEAT-like repeat DUF3437 PF11919.3 ESS69508.1 - 1.2e-21 76.2 0.0 3.6e-21 74.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) HEAT_EZ PF13513.1 ESS69508.1 - 0.71 10.4 4.0 4.8 7.7 0.2 3.6 3 0 0 3 3 3 0 HEAT-like repeat AAA_29 PF13555.1 ESS69509.1 - 0.004 16.6 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 ESS69509.1 - 0.041 14.0 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESS69509.1 - 0.043 14.1 0.0 0.2 11.9 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.1 ESS69509.1 - 0.059 13.2 0.0 0.31 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESS69509.1 - 0.074 13.0 0.1 0.074 13.0 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain MobB PF03205.9 ESS69509.1 - 0.17 11.5 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MGC-24 PF05283.6 ESS69512.1 - 0.0011 18.7 15.7 0.0012 18.6 10.9 1.1 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24) TraG_N PF07916.6 ESS69512.1 - 0.02 13.3 6.1 0.023 13.1 4.2 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Alpha_GJ PF03229.8 ESS69512.1 - 0.097 13.0 15.5 0.14 12.4 10.8 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J TMEM154 PF15102.1 ESS69512.1 - 0.42 10.3 8.6 0.59 9.8 6.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF515 PF04415.7 ESS69512.1 - 2.5 6.2 6.6 2.4 6.3 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Rifin_STEVOR PF02009.11 ESS69512.1 - 3.8 7.0 5.4 4 7.0 3.7 1.1 1 0 0 1 1 1 0 Rifin/stevor family Mucin PF01456.12 ESS69512.1 - 9.5 5.9 31.4 12 5.6 21.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Acyl_transf_3 PF01757.17 ESS69513.1 - 0.2 10.4 20.7 0.22 10.2 14.4 1.0 1 0 0 1 1 1 0 Acyltransferase family DUF2207 PF09972.4 ESS69513.1 - 5.4 5.4 9.4 5.5 5.4 6.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RRM_1 PF00076.17 ESS69514.1 - 1.2e-15 56.9 0.7 0.0029 17.2 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69514.1 - 2.2e-08 33.9 1.2 0.021 14.8 0.0 4.6 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PAM2 PF07145.10 ESS69514.1 - 0.0028 17.0 0.2 0.011 15.1 0.2 2.1 1 0 0 1 1 1 1 Ataxin-2 C-terminal region RRM_5 PF13893.1 ESS69514.1 - 0.25 11.2 0.2 16 5.4 0.0 3.1 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIF1 PF05970.9 ESS69515.1 - 2.9e-50 171.2 0.3 2.1e-42 145.3 0.0 2.9 3 0 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 ESS69515.1 - 4.4e-15 55.7 0.0 8.3e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.9 ESS69515.1 - 1.7e-11 42.7 0.3 1.4e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 Helicase AAA_19 PF13245.1 ESS69515.1 - 1.3e-06 28.0 0.5 3.6e-06 26.6 0.3 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 ESS69515.1 - 1.6e-06 28.2 0.0 4.8e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 ESS69515.1 - 0.00013 22.0 0.0 0.00043 20.3 0.0 2.0 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.1 ESS69515.1 - 0.00024 21.1 0.2 0.00098 19.1 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 ESS69515.1 - 0.0022 17.7 0.0 0.0067 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 ESS69515.1 - 0.0097 15.4 0.3 0.1 12.0 0.1 2.6 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase T2SE PF00437.15 ESS69515.1 - 0.01 14.7 0.0 0.021 13.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_11 PF13086.1 ESS69515.1 - 0.011 15.3 1.8 0.57 9.7 0.2 3.1 2 1 1 3 3 3 0 AAA domain AAA_29 PF13555.1 ESS69515.1 - 0.021 14.3 0.0 0.05 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 ESS69515.1 - 0.021 15.0 0.1 0.052 13.8 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AFG1_ATPase PF03969.11 ESS69515.1 - 0.032 13.0 0.0 0.055 12.2 0.0 1.3 1 0 0 1 1 1 0 AFG1-like ATPase NACHT PF05729.7 ESS69515.1 - 0.033 13.8 0.0 0.076 12.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.10 ESS69515.1 - 0.044 13.4 0.1 0.55 9.9 0.1 2.5 2 0 0 2 2 2 0 NTPase Sigma54_activat PF00158.21 ESS69515.1 - 0.047 13.1 0.0 0.096 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.24 ESS69515.1 - 0.076 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.2 ESS69515.1 - 0.21 10.6 0.0 0.39 9.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region D3 Seadorna_VP6 PF07407.6 ESS69516.1 - 4.8 5.8 9.6 1.9 7.1 2.2 2.6 2 1 0 2 2 2 0 Seadornavirus VP6 protein NAD_binding_10 PF13460.1 ESS69517.1 - 1.4e-05 25.1 0.8 0.0006 19.8 0.1 2.6 3 0 0 3 3 3 1 NADH(P)-binding NAD_binding_4 PF07993.7 ESS69517.1 - 0.00018 20.5 0.0 0.0043 16.0 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein DapB_N PF01113.15 ESS69517.1 - 0.0028 17.5 0.0 0.0068 16.3 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 ESS69517.1 - 0.0042 17.0 0.8 0.014 15.2 0.6 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 ESS69517.1 - 0.0052 16.0 0.0 0.0096 15.2 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 ESS69517.1 - 0.083 12.5 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 KR domain Sel1 PF08238.7 ESS69518.1 - 4e-17 62.2 6.1 4.8e-06 27.0 0.3 5.0 4 1 0 4 4 4 3 Sel1 repeat FliG_N PF14842.1 ESS69518.1 - 0.023 14.8 0.6 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 FliG N-terminal domain FbpA PF05833.6 ESS69518.1 - 0.088 11.3 1.1 0.24 9.9 0.4 1.9 1 1 1 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) Erythro-docking PF09277.6 ESS69518.1 - 0.088 12.5 3.2 0.12 12.0 0.8 2.3 2 0 0 2 2 2 0 Erythronolide synthase, docking E1-E2_ATPase PF00122.15 ESS69519.1 - 1.3e-24 86.5 0.1 3.5e-24 85.1 0.1 1.7 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 ESS69519.1 - 2.8e-21 76.5 0.0 4.8e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESS69519.1 - 1.4e-18 68.0 0.0 4.3e-18 66.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESS69519.1 - 1.2e-07 31.5 0.0 4e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESS69519.1 - 0.0069 15.9 0.6 0.027 14.0 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Nop14 PF04147.7 ESS69519.1 - 0.71 7.7 0.2 1.1 7.1 0.2 1.2 1 0 0 1 1 1 0 Nop14-like family zf-C2H2 PF00096.21 ESS69521.1 - 3.7e-08 33.2 7.6 0.00026 21.1 0.6 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESS69521.1 - 1.4e-05 25.0 8.0 0.049 13.9 1.2 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESS69521.1 - 7.1e-05 22.5 2.7 0.069 13.0 0.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger SSB PF00436.20 ESS69521.1 - 0.00011 22.0 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 Single-strand binding protein family zf-C2H2_2 PF12756.2 ESS69521.1 - 0.00042 20.3 3.8 0.21 11.7 0.4 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) DUF3505 PF12013.3 ESS69521.1 - 0.002 18.3 0.8 0.085 13.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3505) zf-Di19 PF05605.7 ESS69521.1 - 0.0036 17.4 3.4 0.65 10.1 0.4 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.7 ESS69521.1 - 0.0062 15.1 0.6 0.54 8.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF629) zf-met2 PF12907.2 ESS69521.1 - 0.0073 16.2 1.9 0.0073 16.2 1.3 2.7 2 0 0 2 2 2 1 Zinc-binding zf-H2C2_2 PF13465.1 ESS69521.1 - 0.0083 16.3 5.7 0.49 10.7 0.4 3.0 2 0 0 2 2 2 1 Zinc-finger double domain CpXC PF14353.1 ESS69521.1 - 0.0086 16.0 0.1 6.2 6.8 0.0 2.5 2 0 0 2 2 2 2 CpXC protein C1_4 PF07975.7 ESS69521.1 - 0.02 14.9 0.4 4.4 7.3 0.0 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain zf-met PF12874.2 ESS69521.1 - 0.02 15.0 4.0 0.027 14.6 0.7 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-UBP PF02148.14 ESS69521.1 - 0.078 13.1 0.4 2.1 8.5 0.0 2.6 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Zn-ribbon_8 PF09723.5 ESS69521.1 - 0.079 12.9 0.4 1.7 8.6 0.0 2.8 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.3 ESS69521.1 - 0.1 12.7 3.3 0.29 11.3 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DNA_RNApol_7kD PF03604.8 ESS69521.1 - 0.13 11.7 0.5 0.8 9.2 0.1 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit TFIIS_C PF01096.13 ESS69521.1 - 0.25 11.0 2.7 6.5 6.4 0.2 2.5 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Reo_sigmaC PF04582.7 ESS69522.1 - 0.00013 21.3 9.7 0.012 14.7 4.5 2.5 1 1 1 2 2 2 2 Reovirus sigma C capsid protein DUF2205 PF10224.4 ESS69522.1 - 0.0012 18.4 6.8 0.019 14.5 2.3 2.8 2 0 0 2 2 2 1 Predicted coiled-coil protein (DUF2205) ATG16 PF08614.6 ESS69522.1 - 0.0063 16.3 30.8 0.054 13.3 6.2 3.8 3 1 1 4 4 4 2 Autophagy protein 16 (ATG16) AAA_13 PF13166.1 ESS69522.1 - 0.016 13.6 11.0 0.024 13.1 7.7 1.3 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 ESS69522.1 - 0.029 14.2 0.4 4.7 7.2 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat GAS PF13851.1 ESS69522.1 - 0.035 13.3 20.1 0.01 15.0 6.3 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4201 PF13870.1 ESS69522.1 - 0.045 13.1 18.8 0.068 12.6 12.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Filament PF00038.16 ESS69522.1 - 0.049 13.0 23.5 0.6 9.5 16.3 2.1 1 1 0 1 1 1 0 Intermediate filament protein TPX2 PF06886.6 ESS69522.1 - 0.063 13.3 0.1 0.063 13.3 0.1 3.4 4 1 0 4 4 4 0 Targeting protein for Xklp2 (TPX2) DUF948 PF06103.6 ESS69522.1 - 0.091 12.6 2.8 0.29 11.0 2.0 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.4 ESS69522.1 - 0.12 12.1 29.4 1.1 9.1 5.4 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 ESS69522.1 - 1.9 7.4 24.3 5.8 5.8 2.1 2.3 1 1 1 2 2 2 0 Autophagy protein Apg6 Fib_alpha PF08702.5 ESS69522.1 - 3.2 7.8 12.3 29 4.7 4.9 2.8 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF972 PF06156.8 ESS69522.1 - 4.7 7.6 19.0 8.2 6.8 2.9 3.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) WD40_alt PF14077.1 ESS69522.1 - 4.8 6.8 6.9 2.1 8.0 0.6 2.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif IncA PF04156.9 ESS69522.1 - 6.1 6.3 26.1 6.3 6.3 9.7 2.6 1 1 1 2 2 2 0 IncA protein Carn_acyltransf PF00755.15 ESS69524.1 - 1.9e-55 188.0 0.0 1.2e-54 185.4 0.0 2.0 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF601 PF04642.7 ESS69524.1 - 0.07 12.4 0.8 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 5-FTHF_cyc-lig PF01812.15 ESS69525.1 - 0.46 10.2 3.5 4 7.1 0.1 2.7 2 1 0 2 2 2 0 5-formyltetrahydrofolate cyclo-ligase family UIM PF02809.15 ESS69526.1 - 1.2e-06 27.5 18.0 0.00034 19.9 3.6 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif VWA_2 PF13519.1 ESS69526.1 - 0.00027 21.0 0.0 0.00064 19.8 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain EF-hand_7 PF13499.1 ESS69527.1 - 0.00013 22.0 0.1 0.00066 19.7 0.0 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESS69527.1 - 0.0013 17.8 0.0 0.0029 16.7 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 ESS69527.1 - 0.019 14.2 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 ESS69527.1 - 0.023 14.5 0.0 0.065 13.1 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.1 ESS69527.1 - 0.082 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair UQ_con PF00179.21 ESS69528.1 - 5.5e-42 142.5 0.0 6.2e-42 142.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESS69528.1 - 0.045 13.4 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Rotamase PF00639.16 ESS69529.1 - 1.5e-23 83.2 0.0 1.7e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 ESS69529.1 - 9.6e-17 61.3 0.0 1.2e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 ESS69529.1 - 2.3e-05 25.0 0.0 2.8e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Exonuc_VII_S PF02609.11 ESS69529.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Exonuclease VII small subunit PGA2 PF07543.7 ESS69530.1 - 0.24 11.1 3.7 0.37 10.5 2.6 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 RabGAP-TBC PF00566.13 ESS69531.1 - 3.4e-34 118.1 0.0 4.7e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pex24p PF06398.6 ESS69531.1 - 1.9e-10 40.0 3.8 1.9e-10 40.0 2.6 2.0 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin Dpy-30 PF05186.8 ESS69533.1 - 1.1e-13 50.4 0.0 1.6e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif DUF2614 PF11023.3 ESS69534.1 - 1.3 8.8 7.7 0.71 9.6 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) Got1 PF04178.7 ESS69534.1 - 1.5 8.9 22.9 18 5.4 15.0 2.4 1 1 0 1 1 1 0 Got1/Sft2-like family DUF3040 PF11239.3 ESS69534.1 - 1.9 8.6 6.1 3.4 7.7 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) V-SNARE_C PF12352.3 ESS69535.1 - 1.5e-05 24.9 0.8 2.2e-05 24.4 0.6 1.1 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus EF-hand_1 PF00036.27 ESS69536.1 - 5.2e-26 87.9 11.7 2e-09 36.0 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 ESS69536.1 - 2.5e-22 76.6 7.8 2.4e-09 36.3 0.1 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 ESS69536.1 - 9.3e-21 73.7 7.6 1.6e-11 44.1 2.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESS69536.1 - 1.3e-19 69.5 13.7 2.3e-13 49.5 0.8 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 ESS69536.1 - 1.1e-17 62.5 11.9 8.1e-07 28.1 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 ESS69536.1 - 4.9e-12 45.5 0.1 2.4e-08 33.7 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 ESS69536.1 - 0.00017 21.2 1.6 0.26 11.0 0.0 2.4 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 ESS69536.1 - 0.017 15.4 0.1 7.3 6.9 0.0 2.2 2 0 0 2 2 2 0 Toprim-like DUF853 PF05872.7 ESS69536.1 - 0.045 12.1 0.1 5.5 5.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Metal_resist PF13801.1 ESS69536.1 - 0.13 12.2 1.6 0.19 11.7 0.2 1.9 2 0 0 2 2 2 0 Heavy-metal resistance MgtE_N PF03448.12 ESS69536.1 - 0.45 10.8 5.8 0.35 11.1 0.5 2.4 3 0 0 3 3 2 0 MgtE intracellular N domain EF-hand_10 PF14788.1 ESS69536.1 - 0.48 10.1 2.6 4.5 7.0 0.3 2.7 3 0 0 3 3 3 0 EF hand PMSR PF01625.16 ESS69537.1 - 3.2e-53 179.8 0.2 3.7e-53 179.5 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase DUF1514 PF07438.6 ESS69538.1 - 0.11 12.4 0.4 0.48 10.3 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1514) Sec20 PF03908.8 ESS69540.1 - 0.0003 20.4 0.5 0.00087 18.9 0.0 2.0 2 1 0 2 2 2 1 Sec20 V-SNARE_C PF12352.3 ESS69540.1 - 0.018 15.1 1.3 0.046 13.7 0.9 1.6 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Herpes_pp85 PF04637.7 ESS69540.1 - 0.08 11.2 0.9 0.14 10.3 0.6 1.4 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SNARE PF05739.14 ESS69540.1 - 0.11 12.1 3.5 2.3 7.9 0.1 3.0 3 0 0 3 3 3 0 SNARE domain DUF1664 PF07889.7 ESS69540.1 - 0.17 11.6 1.9 5.2 6.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Suppressor_APC PF11414.3 ESS69540.1 - 0.23 11.2 7.1 0.21 11.3 0.4 3.2 2 2 2 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein DUF2730 PF10805.3 ESS69540.1 - 0.52 10.0 2.7 8.5 6.1 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) CcmD PF04995.9 ESS69540.1 - 7.7 6.3 6.0 0.85 9.4 0.1 2.4 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) TTL PF03133.10 ESS69565.1 - 7.9e-42 143.1 0.0 1.2e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Dynein_heavy PF03028.10 ESS69566.1 - 1.9e-113 379.9 0.0 2.7e-113 379.4 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESS69567.1 - 2e-112 375.7 6.5 2e-112 375.7 4.5 4.9 4 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS69567.1 - 1.8e-80 269.7 0.0 1.4e-79 266.8 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 ESS69567.1 - 4.4e-32 110.7 0.0 2.2e-18 66.3 0.0 6.1 4 2 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_9 PF12781.2 ESS69567.1 - 1.7e-31 108.8 0.1 4e-31 107.6 0.1 1.7 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 ESS69567.1 - 3.5e-30 104.9 0.8 4.8e-29 101.1 0.0 3.3 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 MT PF12777.2 ESS69567.1 - 6.4e-27 94.2 11.0 2e-26 92.5 7.6 1.9 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESS69567.1 - 1.7e-23 83.0 0.3 3.5e-22 78.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_22 PF13401.1 ESS69567.1 - 1e-12 48.2 0.0 0.0022 18.1 0.0 5.8 4 0 0 4 4 4 3 AAA domain AAA_16 PF13191.1 ESS69567.1 - 3e-12 46.8 5.0 0.0067 16.4 0.0 6.2 5 0 0 5 5 5 4 AAA ATPase domain AAA PF00004.24 ESS69567.1 - 2.6e-11 43.8 0.1 0.0093 16.1 0.0 4.9 5 0 0 5 5 3 3 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS69567.1 - 3.8e-09 37.3 0.4 8.1e-05 23.4 0.0 4.7 5 0 0 5 5 3 2 AAA domain AAA_28 PF13521.1 ESS69567.1 - 1.1e-05 25.5 0.1 0.0034 17.3 0.0 4.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 ESS69567.1 - 1.8e-05 24.6 0.4 0.0042 16.9 0.0 4.8 5 0 0 5 5 4 1 AAA domain AAA_18 PF13238.1 ESS69567.1 - 4.3e-05 23.8 0.5 0.0056 16.9 0.0 3.9 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.22 ESS69567.1 - 4.6e-05 23.7 5.8 0.0016 18.7 0.0 5.5 5 1 0 5 5 5 1 ABC transporter DUF258 PF03193.11 ESS69567.1 - 6.2e-05 22.2 0.1 0.00029 20.0 0.0 2.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_19 PF13245.1 ESS69567.1 - 0.0001 21.9 0.3 0.45 10.3 0.0 3.6 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 ESS69567.1 - 0.00012 21.7 0.0 0.16 11.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESS69567.1 - 0.00079 19.5 0.0 2.1 8.5 0.0 3.6 3 0 0 3 3 3 1 RNA helicase IncA PF04156.9 ESS69567.1 - 0.00084 18.9 6.7 0.00084 18.9 4.6 4.8 4 0 0 4 4 4 1 IncA protein AAA_29 PF13555.1 ESS69567.1 - 0.0012 18.3 0.0 0.0086 15.5 0.0 2.5 3 0 0 3 3 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 ESS69567.1 - 0.0016 18.5 0.0 0.0092 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ESS69567.1 - 0.046 13.4 0.0 0.18 11.4 0.0 2.1 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ESS69567.1 - 0.059 12.8 3.0 1.4 8.2 0.0 4.1 4 1 0 4 4 4 0 AAA-like domain TBCC PF07986.7 ESS69568.1 - 9.8e-35 118.5 2.4 1.8e-34 117.6 1.7 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C Shisa PF13908.1 ESS69569.1 - 0.046 13.9 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Bap31 PF05529.7 ESS69569.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Exo_endo_phos PF03372.18 ESS69570.1 - 0.0004 20.4 0.2 0.00088 19.2 0.0 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family ABC2_membrane_4 PF12730.2 ESS69570.1 - 0.019 14.1 3.9 0.5 9.4 0.0 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2854 PF11016.3 ESS69570.1 - 0.094 12.2 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) TMF_TATA_bd PF12325.3 ESS69570.1 - 0.13 11.9 0.1 0.23 11.1 0.1 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4131 PF13567.1 ESS69570.1 - 0.86 8.9 8.7 2.1 7.7 4.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Frag1 PF10277.4 ESS69571.1 - 2e-36 125.5 12.4 2e-36 125.5 8.6 3.0 3 1 0 3 3 3 1 Frag1/DRAM/Sfk1 family Peptidase_M17 PF00883.16 ESS69572.1 - 2.8e-85 285.9 0.0 3.9e-85 285.4 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Ras PF00071.17 ESS69574.1 - 0.00064 19.1 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 Ras family Myc_N PF01056.13 ESS69574.1 - 0.47 9.5 3.9 0.69 9.0 2.7 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Kinesin PF00225.18 ESS69575.1 - 1.4e-103 346.1 0.0 1.7e-103 345.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain FHA PF00498.21 ESS69575.1 - 0.002 18.1 0.0 0.0077 16.3 0.0 1.9 2 0 0 2 2 2 1 FHA domain Peptidase_M32 PF02074.10 ESS69576.1 - 9.1e-130 433.5 0.0 1e-129 433.4 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase NUC173 PF08161.7 ESS69577.1 - 1.1e-09 37.9 0.0 3.3e-09 36.3 0.0 1.9 1 0 0 1 1 1 1 NUC173 domain UDPGP PF01704.13 ESS69578.1 - 1.3e-29 102.9 0.0 1.9e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 ESS69578.1 - 0.00078 19.5 0.1 0.0087 16.1 0.0 2.5 2 1 1 3 3 3 1 MobA-like NTP transferase domain Radial_spoke PF04712.7 ESS69580.1 - 3e-05 22.9 0.0 0.0016 17.2 0.0 2.3 2 1 0 2 2 2 2 Radial spokehead-like protein MRP-S25 PF13741.1 ESS69580.1 - 0.15 11.5 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 Rad51 PF08423.6 ESS69582.1 - 1e-26 93.4 0.6 3e-18 65.6 0.0 4.1 4 0 0 4 4 4 3 Rad51 AAA_25 PF13481.1 ESS69582.1 - 2.9e-11 43.1 0.1 3.7e-10 39.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain KaiC PF06745.8 ESS69582.1 - 8.1e-07 28.3 0.3 1.2e-05 24.5 0.0 2.5 2 1 1 3 3 3 1 KaiC RecA PF00154.16 ESS69582.1 - 3.2e-05 23.1 0.3 7.4e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_19 PF13245.1 ESS69582.1 - 0.0007 19.2 0.6 0.026 14.2 0.0 3.2 3 0 0 3 3 3 1 Part of AAA domain AAA_33 PF13671.1 ESS69582.1 - 0.039 13.8 0.1 0.57 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESS69582.1 - 0.042 14.0 0.0 0.63 10.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 ESS69582.1 - 0.061 12.7 0.0 0.13 11.6 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain DUF4034 PF13226.1 ESS69584.1 - 0.0072 15.4 1.7 0.011 14.8 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4034) Zip PF02535.17 ESS69587.1 - 2 7.3 5.1 0.78 8.6 1.2 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Suf PF05843.9 ESS69587.1 - 3.8 7.1 7.5 0.52 9.9 1.1 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) zf-ZPR1 PF03367.8 ESS69588.1 - 0.8 8.8 5.0 0.74 8.9 1.6 2.3 1 1 2 3 3 3 0 ZPR1 zinc-finger domain Mnd1 PF03962.10 ESS69588.1 - 4.8 6.8 26.2 0.26 10.9 8.2 3.1 1 1 1 3 3 3 0 Mnd1 family Diphthamide_syn PF01866.12 ESS69589.1 - 6.9e-32 110.9 0.4 1.6e-16 60.4 0.0 2.7 3 0 0 3 3 3 2 Putative diphthamide synthesis protein AXH PF08517.7 ESS69589.1 - 0.12 12.5 0.1 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Ataxin-1 and HBP1 module (AXH) MMR_HSR1 PF01926.18 ESS69590.1 - 8.6e-19 67.6 0.2 1.3e-13 50.9 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS69590.1 - 1.2e-13 50.6 0.1 3.4e-09 36.1 0.2 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.18 ESS69590.1 - 7.8e-06 25.8 0.7 0.0084 15.9 0.2 2.8 2 1 0 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 ESS69590.1 - 0.00026 20.4 0.4 0.016 14.6 0.0 2.6 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESS69590.1 - 0.0014 17.8 0.0 0.0032 16.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 ESS69590.1 - 0.0016 18.9 0.2 0.58 10.6 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein Arf PF00025.16 ESS69590.1 - 0.023 13.9 0.1 3.9 6.6 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_17 PF13207.1 ESS69590.1 - 0.026 15.3 0.4 0.23 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 ESS69590.1 - 0.043 12.5 0.0 0.075 11.7 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_18 PF13238.1 ESS69590.1 - 0.1 12.9 0.1 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain HSP90 PF00183.13 ESS69591.1 - 5.6e-75 252.7 2.2 2.6e-74 250.5 0.4 2.0 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.1 ESS69591.1 - 3e-14 52.8 0.1 7.1e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESS69591.1 - 3.5e-05 23.4 0.0 9.8e-05 22.0 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ski_Sno PF02437.12 ESS69591.1 - 0.14 11.7 0.0 0.46 10.0 0.0 1.9 2 0 0 2 2 2 0 SKI/SNO/DAC family GRASP55_65 PF04495.9 ESS69592.1 - 1.5e-43 148.0 0.0 6.1e-31 107.2 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain ALS2CR8 PF15299.1 ESS69593.1 - 0.058 12.9 0.4 0.088 12.3 0.2 1.3 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Peptidase_S46 PF10459.4 ESS69593.1 - 0.1 11.0 0.5 0.16 10.3 0.3 1.3 1 0 0 1 1 1 0 Peptidase S46 Imm29 PF15575.1 ESS69593.1 - 0.1 12.1 0.2 0.2 11.2 0.2 1.4 1 0 0 1 1 1 0 Immunity protein 29 NCA2 PF08637.5 ESS69594.1 - 2.6e-84 282.5 2.2 3.4e-84 282.1 1.5 1.1 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Kei1 PF08552.6 ESS69595.1 - 0.0014 18.2 0.7 0.0016 18.1 0.5 1.0 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 DUF4131 PF13567.1 ESS69595.1 - 0.0056 16.1 3.5 0.011 15.1 2.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4131) Mem_trans PF03547.13 ESS69595.1 - 0.0067 14.7 0.5 0.029 12.6 0.0 1.8 1 1 1 2 2 2 1 Membrane transport protein Coa1 PF08695.5 ESS69595.1 - 0.015 14.8 1.0 0.077 12.4 0.0 2.1 1 1 0 2 2 2 0 Cytochrome oxidase complex assembly protein 1 Ctr PF04145.10 ESS69595.1 - 0.02 14.9 0.6 0.02 14.9 0.4 1.7 1 1 0 1 1 1 0 Ctr copper transporter family ETRAMP PF09716.5 ESS69595.1 - 0.021 14.7 1.4 0.029 14.3 0.3 1.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF599 PF04654.7 ESS69595.1 - 0.029 13.5 0.5 0.029 13.5 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF599 7tm_1 PF00001.16 ESS69595.1 - 0.093 11.8 9.4 0.21 10.7 6.5 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TRP PF06011.7 ESS69595.1 - 0.11 11.0 3.7 0.041 12.4 0.8 1.4 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3611 PF12263.3 ESS69595.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) PrgI PF12666.2 ESS69595.1 - 0.54 10.4 5.9 9.9 6.3 4.0 2.1 1 1 0 1 1 1 0 PrgI family protein Cytochrom_C_asm PF01578.15 ESS69595.1 - 1 8.8 5.7 7.1 6.1 2.5 2.0 1 1 1 2 2 2 0 Cytochrome C assembly protein PDR_CDR PF06422.7 ESS69595.1 - 1.2 8.8 6.4 0.27 10.9 1.3 2.0 1 1 1 2 2 2 0 CDR ABC transporter RDD PF06271.7 ESS69595.1 - 1.6 8.5 6.5 2.4 8.0 4.5 1.5 1 1 0 1 1 1 0 RDD family Tmemb_185A PF10269.4 ESS69595.1 - 2.7 7.5 11.5 11 5.5 8.0 1.8 1 1 0 1 1 1 0 Transmembrane Fragile-X-F protein MFS_2 PF13347.1 ESS69595.1 - 3.5 5.9 7.7 13 4.0 5.4 1.8 1 1 0 1 1 1 0 MFS/sugar transport protein EphA2_TM PF14575.1 ESS69595.1 - 5 7.5 7.4 3.9 7.9 1.1 2.5 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF3810 PF12725.2 ESS69595.1 - 7.4 5.3 8.5 18 4.0 5.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) zf-DHHC PF01529.15 ESS69595.1 - 8.8 5.6 18.2 25 4.2 12.6 1.7 1 1 0 1 1 1 0 DHHC palmitoyltransferase TMEM223 PF14640.1 ESS69595.1 - 9 6.2 8.2 0.16 11.8 0.4 1.8 2 0 0 2 2 2 0 Transmembrane protein 223 CoA_trans PF01144.18 ESS69596.1 - 7.9e-97 322.6 1.8 2.4e-60 203.4 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.1 ESS69596.1 - 0.0018 17.9 0.0 0.0035 17.0 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Laminin_II PF06009.7 ESS69597.1 - 0.027 14.2 5.8 0.53 10.0 0.0 4.5 5 0 0 5 5 5 0 Laminin Domain II CDC14 PF08045.6 ESS69597.1 - 0.15 11.1 3.4 0.3 10.1 0.4 2.5 3 0 0 3 3 3 0 Cell division control protein 14, SIN component DivIC PF04977.10 ESS69597.1 - 1.3 8.5 0.0 1.3 8.5 0.0 4.6 6 0 0 6 6 6 0 Septum formation initiator CDC45 PF02724.9 ESS69599.1 - 2.3e-129 432.2 0.0 2.9e-129 431.9 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF1168 PF06658.7 ESS69599.1 - 0.021 14.3 8.9 0.041 13.4 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Cytochrom_C552 PF02335.10 ESS69599.1 - 0.024 13.3 0.0 0.04 12.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c552 PRP21_like_P PF12230.3 ESS69600.1 - 0.002 17.7 1.6 0.004 16.6 1.1 1.5 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Epimerase PF01370.16 ESS69601.1 - 8.3e-41 139.9 0.0 1.2e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 ESS69601.1 - 7.4e-14 51.3 0.0 3.4e-13 49.1 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase_Csub PF13950.1 ESS69601.1 - 3.1e-13 49.4 0.0 5.7e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit NAD_binding_4 PF07993.7 ESS69601.1 - 8.8e-12 44.4 0.0 1.2e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 ESS69601.1 - 7.8e-10 37.9 0.0 4.3e-09 35.4 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 ESS69601.1 - 9.3e-08 32.1 0.1 2.1e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 ESS69601.1 - 5.4e-07 28.7 0.0 2.2e-06 26.7 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.5 ESS69601.1 - 7.4e-07 29.0 0.1 2e-06 27.6 0.1 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 ESS69601.1 - 0.018 14.3 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.1 ESS69601.1 - 0.031 14.2 0.6 4.4 7.2 0.1 2.3 2 0 0 2 2 2 0 NADH(P)-binding Pkinase PF00069.20 ESS69602.1 - 3.2e-46 157.6 0.0 5.2e-46 156.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69602.1 - 5.6e-33 114.1 0.0 8.9e-33 113.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69602.1 - 0.016 14.1 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like zf-MYND PF01753.13 ESS69603.1 - 9.8e-07 28.5 13.1 9.8e-07 28.5 9.1 1.8 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.1 ESS69603.1 - 0.2 11.5 5.6 0.6 10.0 3.9 1.8 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Ral PF11058.3 ESS69603.1 - 3.7 6.9 6.8 3.8 6.9 3.7 1.7 2 0 0 2 2 2 0 Antirestriction protein Ral CRA_rpt PF07046.6 ESS69604.1 - 6e-27 93.3 52.0 2.1e-19 69.1 16.8 4.0 2 2 1 3 3 3 2 Cytoplasmic repetitive antigen (CRA) like repeat ERM PF00769.14 ESS69604.1 - 4.2 6.8 32.1 5.6 6.4 22.3 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SOBP PF15279.1 ESS69604.1 - 8.2 6.7 7.6 9.8 6.4 5.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein zf-C3HC4_3 PF13920.1 ESS69605.1 - 0.0035 16.9 12.7 0.0054 16.3 8.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS69605.1 - 0.16 12.0 15.0 0.26 11.3 10.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3762 PF12591.3 ESS69606.1 - 0.037 14.0 0.2 0.58 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3762) NuA4 PF09340.5 ESS69607.1 - 0.11 12.1 3.5 0.65 9.6 0.0 2.8 3 0 0 3 3 3 0 Histone acetyltransferase subunit NuA4 Pkinase PF00069.20 ESS69608.1 - 2.5e-07 30.1 0.0 8.1e-07 28.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain PaaSYMP PF14738.1 ESS69609.1 - 7.6e-47 158.8 10.9 7.6e-47 158.8 7.5 2.6 2 0 0 2 2 2 1 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 DUF3773 PF12608.3 ESS69610.1 - 1.1e-33 115.1 5.0 1.9e-33 114.3 3.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3773) CENP-T PF15511.1 ESS69610.1 - 5.4 6.1 12.9 6.8 5.8 9.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T WD40 PF00400.27 ESS69613.1 - 0.00048 19.8 1.0 1.2 9.1 0.0 4.4 4 1 0 4 4 4 2 WD domain, G-beta repeat PQQ_2 PF13360.1 ESS69613.1 - 0.022 14.2 0.0 0.1 12.0 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain DUF1216 PF06746.6 ESS69614.1 - 0.011 15.5 0.1 0.031 14.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) DUF4322 PF14210.1 ESS69614.1 - 0.024 14.0 0.1 0.22 11.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4322) SBP_bac_6 PF13343.1 ESS69614.1 - 0.043 13.1 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Acid_PPase PF12689.2 ESS69615.1 - 7.1e-47 159.1 0.0 8.4e-47 158.9 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase NIF PF03031.13 ESS69615.1 - 0.11 12.2 0.1 0.78 9.3 0.1 2.1 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESS69615.1 - 0.13 12.4 0.0 5.6 7.1 0.0 2.3 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF2608 PF11019.3 ESS69615.1 - 0.18 10.7 0.7 0.94 8.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) WD40 PF00400.27 ESS69616.1 - 7.5e-09 35.1 10.6 0.29 11.0 0.1 5.6 4 1 0 4 4 4 4 WD domain, G-beta repeat Dynein_heavy PF03028.10 ESS69616.1 - 0.0042 15.2 0.0 0.0059 14.6 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF3312 PF11768.3 ESS69616.1 - 0.077 11.2 0.0 0.12 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) PQQ_3 PF13570.1 ESS69616.1 - 1.1 9.5 7.8 10 6.5 0.1 4.6 5 0 0 5 5 5 0 PQQ-like domain Kinesin PF00225.18 ESS69617.1 - 8.8e-80 267.9 0.0 1.5e-79 267.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain ATG16 PF08614.6 ESS69617.1 - 0.0016 18.2 1.0 0.0016 18.2 0.7 2.6 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) DUF3347 PF11827.3 ESS69617.1 - 0.18 11.7 2.7 0.41 10.6 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) His_Phos_1 PF00300.17 ESS69619.1 - 4.8e-18 65.7 0.0 6.5e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.17 ESS69620.1 - 3.2e-27 95.5 0.0 4.4e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 ESS69620.1 - 0.013 14.8 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DUF3223 PF11523.3 ESS69621.1 - 0.13 12.5 0.0 3.5 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3223) DUF383 PF04063.9 ESS69622.1 - 4.5e-05 23.0 0.1 0.00023 20.7 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF383) Nup84_Nup100 PF04121.8 ESS69624.1 - 3e-07 28.5 2.4 0.00048 17.9 0.4 2.6 2 1 1 3 3 3 2 Nuclear pore protein 84 / 107 Arm PF00514.18 ESS69625.1 - 0.0025 17.5 4.1 37 4.3 0.0 6.1 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat BNR_3 PF13859.1 ESS69626.1 - 1.2e-42 146.0 0.0 1.5e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 ESS69627.1 - 2e-39 135.4 0.0 2.6e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Cytochrom_B_N_2 PF13631.1 ESS69628.1 - 0.053 13.3 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB PUF PF00806.14 ESS69628.1 - 0.18 11.3 0.2 0.76 9.3 0.0 2.2 2 1 0 2 2 2 0 Pumilio-family RNA binding repeat Tautomerase PF01361.16 ESS69629.1 - 0.074 12.6 0.0 0.58 9.8 0.0 2.4 3 0 0 3 3 3 0 Tautomerase enzyme DUF1679 PF07914.6 ESS69629.1 - 0.082 11.5 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) VERL PF11386.3 ESS69629.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Vitelline envelope receptor for lysin Pribosyltran_N PF13793.1 ESS69631.1 - 1.5e-37 127.8 0.0 3.7e-37 126.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ESS69631.1 - 5.4e-24 84.9 0.5 2.8e-23 82.6 0.1 2.1 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ESS69631.1 - 7.9e-12 44.9 0.2 2.1e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pho88 PF10032.4 ESS69633.1 - 4.4e-31 107.6 0.0 5e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) CAF1C_H4-bd PF12265.3 ESS69634.1 - 7.3e-17 61.0 0.0 1.7e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 ESS69634.1 - 1.2e-06 28.1 9.8 0.011 15.5 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat Nop25 PF09805.4 ESS69634.1 - 3.2 7.8 12.8 2.1 8.4 6.2 2.3 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) LRR_6 PF13516.1 ESS69635.1 - 0.056 13.5 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 Leucine Rich repeat IQ PF00612.22 ESS69637.1 - 8.8e-05 21.8 0.5 0.00034 19.9 0.3 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif DVL PF08137.7 ESS69637.1 - 0.16 11.4 0.3 0.16 11.4 0.2 2.1 2 0 0 2 2 2 0 DVL family NOG1 PF06858.9 ESS69638.1 - 2.1e-27 94.7 0.0 5.8e-27 93.3 0.0 1.8 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.6 ESS69638.1 - 7.9e-24 83.1 4.4 1.7e-23 82.0 3.1 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.18 ESS69638.1 - 1.8e-16 60.1 0.0 3.8e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS69638.1 - 7.5e-10 38.2 0.0 1.3e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 ESS69638.1 - 8.3e-05 23.0 0.0 0.00021 21.7 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 ESS69638.1 - 0.022 13.8 0.0 0.042 12.9 0.0 1.5 1 0 0 1 1 1 0 AIG1 family SRPRB PF09439.5 ESS69638.1 - 0.045 12.9 0.0 0.078 12.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 ESS69638.1 - 0.088 12.6 0.1 20 4.9 0.0 2.8 1 1 1 2 2 2 0 Dynamin family ABC_membrane_2 PF06472.10 ESS69639.1 - 1.4e-85 286.9 0.5 1.9e-85 286.4 0.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESS69639.1 - 3.2e-15 56.6 0.0 5.8e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 ESS69639.1 - 0.0099 16.0 0.1 0.055 13.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain NACHT PF05729.7 ESS69639.1 - 0.011 15.3 0.2 0.033 13.8 0.1 1.9 1 1 0 1 1 1 0 NACHT domain FtsK_SpoIIIE PF01580.13 ESS69639.1 - 0.035 13.5 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.1 ESS69639.1 - 0.036 14.0 0.0 0.11 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF3584 PF12128.3 ESS69639.1 - 0.17 9.1 0.4 0.25 8.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Pkinase PF00069.20 ESS69640.1 - 4.5e-55 186.5 0.0 5.6e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69640.1 - 7.6e-23 80.9 0.0 1e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS69640.1 - 0.0006 19.6 0.0 0.003 17.3 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS69640.1 - 0.022 14.3 0.5 0.18 11.3 0.0 2.3 2 1 1 3 3 3 0 Choline/ethanolamine kinase Kdo PF06293.9 ESS69640.1 - 0.08 11.9 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_2 PF07647.12 ESS69643.1 - 5.2e-12 45.4 0.0 9.3e-12 44.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESS69643.1 - 1.3e-05 25.2 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LisH PF08513.6 ESS69644.1 - 2.1e-05 24.1 0.1 4.7e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 LisH WD40 PF00400.27 ESS69644.1 - 0.058 13.3 3.9 4.7 7.2 0.1 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat DOT1 PF08123.8 ESS69645.1 - 4.1e-15 55.6 0.1 7.3e-15 54.8 0.1 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 ESS69645.1 - 0.00022 21.7 0.0 0.00031 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS69645.1 - 0.00023 21.1 0.0 0.00031 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS69645.1 - 0.0019 17.8 0.1 0.0036 16.9 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Glyco_hydro_10 PF00331.15 ESS69645.1 - 0.0032 16.5 0.0 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Tubulin PF00091.20 ESS69645.1 - 0.0083 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Methyltransf_4 PF02390.12 ESS69645.1 - 0.019 14.0 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_12 PF08242.7 ESS69645.1 - 0.025 15.0 0.0 0.043 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.7 ESS69645.1 - 0.087 12.1 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Peptidase_M48 PF01435.13 ESS69646.1 - 4.9e-37 127.6 0.0 6.4e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M48 Aa_trans PF01490.13 ESS69647.1 - 1.1e-54 185.5 29.3 1.1e-54 185.5 20.3 1.8 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESS69647.1 - 3.5e-07 29.4 26.6 3.5e-07 29.4 18.5 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Ank_2 PF12796.2 ESS69648.1 - 3.4e-11 43.3 0.0 6.1e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESS69648.1 - 4.6e-09 35.6 0.0 4.6e-06 26.1 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESS69648.1 - 1.4e-08 34.9 0.0 5.4e-06 26.7 0.0 3.3 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS69648.1 - 5.3e-08 32.3 0.0 0.0003 20.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESS69648.1 - 0.044 14.0 0.0 0.69 10.2 0.0 2.8 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Dynein_heavy PF03028.10 ESS69648.1 - 0.084 10.8 0.0 0.1 10.5 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor FMN_dh PF01070.13 ESS69649.1 - 4e-31 108.1 0.0 3.1e-21 75.6 0.0 2.0 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.20 ESS69649.1 - 2.2e-05 23.5 0.3 0.0008 18.3 0.1 2.4 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 ESS69649.1 - 0.00023 20.1 0.4 0.00053 19.0 0.2 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.16 ESS69649.1 - 0.025 13.8 0.0 0.086 12.0 0.0 1.8 2 0 0 2 2 2 0 Histidine biosynthesis protein NMO PF03060.10 ESS69649.1 - 0.078 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.16 ESS69649.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase SAC3_GANP PF03399.11 ESS69650.1 - 1.8e-27 96.2 0.0 3.3e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family TGS PF02824.16 ESS69651.1 - 1.3e-19 69.7 0.1 3.1e-19 68.5 0.0 1.7 2 0 0 2 2 2 1 TGS domain MMR_HSR1 PF01926.18 ESS69651.1 - 1.6e-16 60.3 0.0 4.6e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS69651.1 - 2.4e-09 36.6 0.0 4.3e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESS69651.1 - 0.002 17.9 0.0 0.21 11.3 0.0 2.4 2 0 0 2 2 2 1 Dynamin family Miro PF08477.8 ESS69651.1 - 0.014 15.8 0.0 0.04 14.4 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 ESS69651.1 - 0.044 13.7 0.0 0.088 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain WD40 PF00400.27 ESS69654.1 - 5.4e-19 67.2 13.8 5.5e-07 29.2 0.1 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat Methyltransf_4 PF02390.12 ESS69655.1 - 3.2e-34 117.7 0.0 3.7e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESS69655.1 - 4.9e-06 27.1 0.0 8.2e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS69655.1 - 9e-05 22.1 0.0 0.00022 20.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS69655.1 - 0.0069 16.7 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS69655.1 - 0.0099 16.3 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS69655.1 - 0.095 13.2 0.0 0.29 11.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain DUF904 PF06005.7 ESS69656.1 - 0.02 15.1 2.3 0.02 15.1 1.6 5.5 4 2 1 5 5 5 0 Protein of unknown function (DUF904) IncA PF04156.9 ESS69656.1 - 0.58 9.7 29.8 0.53 9.8 0.2 3.9 2 1 2 4 4 4 0 IncA protein PIN PF01850.16 ESS69656.1 - 0.75 10.1 6.5 0.28 11.5 0.2 2.9 3 0 0 3 3 3 0 PIN domain Med9 PF07544.8 ESS69656.1 - 0.91 9.3 20.1 0.52 10.0 2.2 4.7 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 GAS PF13851.1 ESS69656.1 - 7.3 5.7 30.1 0.22 10.7 2.4 3.8 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding MMR_HSR1 PF01926.18 ESS69657.1 - 7.3e-11 42.0 0.0 3.9e-09 36.4 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESS69657.1 - 4.3e-05 22.7 0.0 8.8e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESS69657.1 - 0.0027 17.8 0.0 0.0071 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Dynamin_N PF00350.18 ESS69657.1 - 0.019 14.8 0.3 1.3 8.8 0.0 2.6 1 1 1 2 2 2 0 Dynamin family FeoB_N PF02421.13 ESS69657.1 - 0.021 14.1 0.0 0.049 12.9 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF830 PF05708.7 ESS69659.1 - 2.3e-05 24.4 0.0 0.0047 16.9 0.0 2.1 2 0 0 2 2 2 2 Orthopoxvirus protein of unknown function (DUF830) MMR_HSR1 PF01926.18 ESS69660.1 - 6.1e-05 22.9 0.0 9.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESS69660.1 - 0.0018 18.3 0.0 0.0031 17.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 ESS69660.1 - 0.0048 16.3 0.0 0.011 15.1 0.0 1.7 1 1 1 2 2 2 1 AAA domain Miro PF08477.8 ESS69660.1 - 0.036 14.5 0.0 0.072 13.5 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 ESS69660.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.13 ESS69660.1 - 0.13 11.5 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF258 PF03193.11 ESS69660.1 - 0.14 11.3 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Pkinase PF00069.20 ESS69661.1 - 9.7e-43 146.1 0.0 1.4e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69661.1 - 3.6e-16 59.0 0.0 6.1e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69661.1 - 1.1e-07 31.0 0.0 3.4e-07 29.5 0.0 1.6 1 1 1 2 2 2 1 Kinase-like PAS_9 PF13426.1 ESS69661.1 - 0.00062 20.1 0.0 0.0025 18.1 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 ESS69661.1 - 0.0014 18.4 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold Kdo PF06293.9 ESS69661.1 - 0.017 14.1 0.1 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_10 PF13596.1 ESS69661.1 - 0.2 11.9 0.0 0.55 10.5 0.0 1.7 1 0 0 1 1 1 0 PAS domain IQ PF00612.22 ESS69662.1 - 0.0051 16.3 2.1 0.0073 15.8 0.3 2.2 1 1 1 2 2 2 1 IQ calmodulin-binding motif Exo70 PF03081.10 ESS69663.1 - 0.096 11.4 0.0 0.2 10.3 0.0 1.5 1 0 0 1 1 1 0 Exo70 exocyst complex subunit Glycos_transf_1 PF00534.15 ESS69664.1 - 2.2e-22 79.2 0.0 3.6e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESS69664.1 - 1.2e-10 41.6 0.0 2.1e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESS69664.1 - 0.037 14.2 0.0 0.098 12.9 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 MAP65_ASE1 PF03999.7 ESS69666.1 - 0.18 10.4 3.3 0.073 11.6 0.3 1.6 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) RRN3 PF05327.6 ESS69666.1 - 0.34 8.9 1.9 0.6 8.1 1.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RRM_1 PF00076.17 ESS69668.1 - 1.7e-81 267.8 7.8 3.4e-24 84.2 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69668.1 - 7.3e-52 173.2 3.9 1.1e-14 54.1 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69668.1 - 1.4e-34 117.6 5.0 4.8e-10 39.1 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 ESS69668.1 - 8.4e-21 73.4 0.1 1.9e-19 69.0 0.0 2.5 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.6 ESS69668.1 - 4.8e-07 29.5 0.9 0.1 12.4 0.3 4.2 4 0 0 4 4 4 2 RNA binding motif Nup35_RRM_2 PF14605.1 ESS69668.1 - 0.00057 19.5 0.5 13 5.6 0.0 4.2 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.1 ESS69668.1 - 0.0053 16.2 0.0 0.58 9.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) Pkinase_C PF00433.19 ESS69668.1 - 0.017 15.6 0.0 0.046 14.2 0.0 1.8 1 1 0 1 1 1 0 Protein kinase C terminal domain TC1 PF15063.1 ESS69668.1 - 0.09 12.3 0.0 0.41 10.2 0.0 2.2 2 0 0 2 2 2 0 Thyroid cancer protein 1 MIase PF02426.11 ESS69669.1 - 0.082 12.7 0.6 0.49 10.2 0.4 2.3 1 1 0 1 1 1 0 Muconolactone delta-isomerase MgsA_C PF12002.3 ESS69670.1 - 0.012 15.3 0.5 0.017 14.7 0.3 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal HEAT_2 PF13646.1 ESS69670.1 - 0.026 14.7 0.1 0.12 12.6 0.1 2.2 2 1 0 2 2 2 0 HEAT repeats DivIVA PF05103.8 ESS69670.1 - 0.15 12.1 0.3 0.23 11.5 0.2 1.3 1 0 0 1 1 1 0 DivIVA protein Ion_trans_2 PF07885.11 ESS69670.1 - 0.16 11.7 0.3 0.37 10.5 0.2 1.5 1 1 0 1 1 1 0 Ion channel DUF2893 PF11459.3 ESS69671.1 - 0.098 12.4 1.2 7.4 6.4 0.0 3.3 2 1 0 3 3 3 0 Protein of unknwon function (DUF2893) MFS_1 PF07690.11 ESS69672.1 - 0.042 12.5 3.1 0.071 11.8 2.2 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily CBM_11 PF03425.8 ESS69672.1 - 0.075 12.7 0.0 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Carbohydrate binding domain (family 11) Pkinase PF00069.20 ESS69674.1 - 3.2e-69 232.9 0.0 4e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69674.1 - 4.2e-33 114.5 0.0 7.1e-33 113.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS69674.1 - 9.7e-06 24.7 0.0 3.6e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 ESS69674.1 - 0.0016 18.2 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESS69674.1 - 0.033 13.0 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PIP49_C PF12260.3 ESS69674.1 - 0.073 12.4 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 PAP2_C PF14360.1 ESS69675.1 - 9.6e-20 70.6 9.1 9.6e-20 70.6 6.3 2.7 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 ESS69675.1 - 0.0073 15.8 9.0 0.015 14.7 6.2 1.6 1 1 0 1 1 1 1 PAP2 superfamily PWWP PF00855.12 ESS69675.1 - 0.14 12.3 0.1 0.4 10.8 0.1 1.8 1 0 0 1 1 1 0 PWWP domain PAP2 PF01569.16 ESS69675.1 - 0.26 10.9 7.6 0.58 9.8 5.3 1.7 1 1 0 1 1 1 0 PAP2 superfamily DUF1505 PF07403.6 ESS69676.1 - 0.041 13.8 3.3 0.051 13.5 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1505) SSP160 PF06933.6 ESS69676.1 - 0.063 11.2 17.6 0.067 11.1 12.2 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SoxE PF06525.6 ESS69676.1 - 0.12 11.6 6.0 0.16 11.2 4.2 1.2 1 0 0 1 1 1 0 Sulfocyanin (SoxE) 4_1_CTD PF05902.8 ESS69676.1 - 0.49 10.4 6.9 0.56 10.2 4.8 1.1 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) Sporozoite_P67 PF05642.6 ESS69676.1 - 2.7 5.7 8.0 2.7 5.7 5.5 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dicty_REP PF05086.7 ESS69676.1 - 6.4 4.4 13.0 7.5 4.1 9.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AAA_22 PF13401.1 ESS69691.1 - 0.0005 20.2 0.0 0.0022 18.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS69691.1 - 0.0016 18.4 0.1 0.0039 17.1 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.12 ESS69691.1 - 0.014 15.2 0.3 0.036 13.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 NACHT PF05729.7 ESS69691.1 - 0.02 14.5 0.0 0.16 11.6 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.1 ESS69691.1 - 0.033 13.5 0.2 0.45 9.8 0.1 2.4 1 1 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESS69691.1 - 0.042 13.7 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESS69691.1 - 0.046 13.2 0.0 0.094 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 ESS69691.1 - 0.058 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF3051 PF11252.3 ESS69691.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) AAA PF00004.24 ESS69691.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESS69691.1 - 0.14 11.9 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain DUF814 PF05670.8 ESS69692.1 - 3.2e-23 81.4 0.1 1.1e-22 79.7 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF814) KIAA1430 PF13879.1 ESS69692.1 - 0.12 12.8 6.2 0.24 11.8 4.3 1.5 1 0 0 1 1 1 0 KIAA1430 homologue DUF2215 PF10225.4 ESS69692.1 - 0.19 11.1 1.4 0.25 10.7 1.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Mgr1 PF08602.5 ESS69692.1 - 0.76 8.7 7.1 1.2 8.0 0.0 2.0 1 1 1 2 2 2 0 Mgr1-like, i-AAA protease complex subunit Cytochrom_B561 PF03188.11 ESS69694.1 - 7.5e-10 38.7 6.7 1.6e-09 37.6 4.7 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Arteri_Gl PF00951.13 ESS69694.1 - 0.0011 18.6 2.1 0.0011 18.6 1.5 2.0 2 0 0 2 2 2 1 Arterivirus GL envelope glycoprotein SdpI PF13630.1 ESS69694.1 - 0.0034 17.0 5.2 0.0034 17.0 3.6 3.4 3 1 0 3 3 3 1 SdpI/YhfL protein family DUF2306 PF10067.4 ESS69694.1 - 1.7 8.8 16.2 0.73 9.9 3.5 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2306) Peptidase_C2 PF00648.16 ESS69695.1 - 8.6e-35 120.1 1.2 2.5e-17 62.8 0.5 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.17 ESS69695.1 - 4.1e-14 52.4 0.0 1.3e-11 44.3 0.0 2.6 2 0 0 2 2 2 2 Calpain large subunit, domain III Mannosyl_trans PF05007.8 ESS69697.1 - 6e-85 284.9 17.0 9.3e-85 284.3 11.8 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 ESS69697.1 - 3.6e-08 32.6 27.1 4.4e-08 32.3 18.3 1.4 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 ESS69697.1 - 6.3e-08 32.4 23.2 1.4e-05 24.6 15.6 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2029) IFT20 PF14931.1 ESS69698.1 - 4.2e-24 84.7 7.7 4.6e-24 84.6 5.3 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 4HB_MCP_1 PF12729.2 ESS69698.1 - 0.055 12.8 0.9 0.056 12.7 0.6 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF3552 PF12072.3 ESS69698.1 - 0.14 11.3 6.6 0.15 11.2 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) IncA PF04156.9 ESS69698.1 - 0.59 9.7 5.2 0.66 9.5 3.6 1.1 1 0 0 1 1 1 0 IncA protein PC_rep PF01851.17 ESS69699.1 - 0.00046 20.2 14.6 8.1 6.9 0.0 5.9 6 0 0 6 6 6 4 Proteasome/cyclosome repeat Dapper PF15268.1 ESS69699.1 - 0.16 10.7 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Dapper DUF1738 PF08401.6 ESS69701.1 - 0.018 14.7 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) zf-C2H2_2 PF12756.2 ESS69703.1 - 1.1e-15 57.5 7.1 2.5e-12 46.7 1.0 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.7 ESS69703.1 - 0.062 13.4 0.3 0.062 13.4 0.2 4.2 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C3HC4_3 PF13920.1 ESS69703.1 - 2.2 8.0 7.5 4.6 6.9 0.1 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Peptidase_S26 PF10502.4 ESS69705.1 - 0.0079 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 COG2 PF06148.6 ESS69705.1 - 0.28 11.0 13.5 1.2 9.0 0.0 3.9 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 LMBR1 PF04791.11 ESS69705.1 - 1.3 7.5 4.9 0.64 8.5 1.4 1.6 1 1 0 1 1 1 0 LMBR1-like membrane protein IncA PF04156.9 ESS69705.1 - 2.2 7.8 30.5 0.11 12.1 4.5 3.4 3 0 0 3 3 3 0 IncA protein PseudoU_synth_2 PF00849.17 ESS69706.1 - 1.3e-21 77.1 0.0 4.6e-10 39.5 0.0 2.3 2 0 0 2 2 2 2 RNA pseudouridylate synthase FAM178 PF14816.1 ESS69709.1 - 0.82 8.3 3.6 1.4 7.5 2.5 1.3 1 0 0 1 1 1 0 Family of unknown function, FAM178 DUF3449 PF11931.3 ESS69711.1 - 2.8e-46 157.5 0.3 4.6e-46 156.8 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) Hph PF13694.1 ESS69711.1 - 0.0079 16.2 0.1 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Sec63/Sec62 complex-interacting family MYCBPAP PF14646.1 ESS69712.1 - 7e-10 38.1 0.3 0.0073 15.0 0.0 5.3 6 0 0 6 6 6 3 MYCBP-associated protein family PapD-like PF14874.1 ESS69712.1 - 0.0042 17.0 0.2 13 5.8 0.0 5.0 5 0 0 5 5 5 1 Flagellar-associated PapD-like Motile_Sperm PF00635.21 ESS69712.1 - 0.03 13.9 10.2 12 5.6 0.0 6.7 9 0 0 9 9 9 0 MSP (Major sperm protein) domain Motile_Sperm PF00635.21 ESS69713.1 - 0.032 13.8 0.7 3.3 7.3 0.0 3.9 5 0 0 5 5 5 0 MSP (Major sperm protein) domain PapD-like PF14874.1 ESS69714.1 - 1.3e-21 76.4 11.6 5e-05 23.1 0.3 9.0 9 0 0 9 9 8 5 Flagellar-associated PapD-like AAA_17 PF13207.1 ESS69714.1 - 4.7e-07 30.6 0.0 1.7e-06 28.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain Motile_Sperm PF00635.21 ESS69714.1 - 0.00011 21.7 11.8 2.7 7.6 0.3 9.2 11 0 0 11 11 11 1 MSP (Major sperm protein) domain ADK PF00406.17 ESS69714.1 - 0.00013 21.8 0.0 0.00032 20.6 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase AAA_14 PF13173.1 ESS69714.1 - 0.0028 17.5 0.0 0.0083 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS69714.1 - 0.004 17.0 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESS69714.1 - 0.0095 16.1 0.0 0.2 11.8 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ESS69714.1 - 0.011 15.5 0.0 0.029 14.0 0.0 1.8 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.1 ESS69714.1 - 0.012 15.7 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 ESS69714.1 - 0.014 14.6 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.1 ESS69714.1 - 0.015 15.6 0.2 0.084 13.1 0.0 2.5 3 0 0 3 3 1 0 AAA domain Thymidylate_kin PF02223.12 ESS69714.1 - 0.016 14.5 0.0 0.04 13.3 0.0 1.6 1 0 0 1 1 1 0 Thymidylate kinase Arch_ATPase PF01637.13 ESS69714.1 - 0.029 14.0 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase Zeta_toxin PF06414.7 ESS69714.1 - 0.038 13.0 0.0 0.089 11.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 ESS69714.1 - 0.039 13.9 0.1 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain TGT PF01702.13 ESS69715.1 - 3e-91 304.9 0.0 3.9e-91 304.5 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Pkinase PF00069.20 ESS69716.1 - 7.6e-37 126.8 0.0 1.2e-36 126.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69716.1 - 1.8e-12 46.9 0.0 3.3e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS69716.1 - 0.0014 18.4 0.0 0.0036 17.0 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family IFT46_B_C PF12317.3 ESS69717.1 - 3.1e-91 304.5 0.3 4.5e-91 303.9 0.2 1.2 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal CLASP_N PF12348.3 ESS69718.1 - 5.3e-08 32.4 7.9 0.00024 20.5 0.7 4.5 4 1 0 4 4 4 3 CLASP N terminal NUC173 PF08161.7 ESS69718.1 - 0.0001 21.7 1.9 0.031 13.6 0.0 3.5 2 1 1 3 3 3 2 NUC173 domain HEAT PF02985.17 ESS69718.1 - 0.00012 21.8 11.0 2.1 8.6 0.0 7.6 7 0 0 7 7 7 3 HEAT repeat Kelch_6 PF13964.1 ESS69719.1 - 3.7e-15 55.3 2.1 4.4e-05 23.4 0.0 6.0 5 2 1 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ESS69719.1 - 2.6e-14 52.7 0.3 0.039 13.7 0.1 6.3 5 3 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS69719.1 - 4.9e-14 51.8 3.3 0.0018 18.1 0.2 6.5 5 2 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESS69719.1 - 1.4e-11 43.7 0.1 0.087 12.3 0.1 5.8 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESS69719.1 - 3.3e-10 39.8 8.2 0.00043 20.3 0.1 5.5 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESS69719.1 - 1.6e-09 37.1 0.6 0.0028 17.3 0.1 5.4 5 0 0 5 5 5 2 Kelch motif GAS PF13851.1 ESS69720.1 - 7.1e-05 22.0 5.5 7.1e-05 22.0 3.8 2.1 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Filament PF00038.16 ESS69720.1 - 0.011 15.2 21.8 0.016 14.7 2.6 3.0 1 1 1 2 2 2 0 Intermediate filament protein HAUS-augmin3 PF14932.1 ESS69720.1 - 0.15 11.1 15.3 0.047 12.8 6.3 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4201 PF13870.1 ESS69720.1 - 0.36 10.2 17.0 0.24 10.8 5.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.4 ESS69720.1 - 1.1 9.0 22.4 0.033 14.0 8.5 2.8 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Occludin_ELL PF07303.8 ESS69720.1 - 1.4 9.7 10.5 1.2 9.9 0.7 3.2 2 1 1 3 3 3 0 Occludin homology domain Lzipper-MIP1 PF14389.1 ESS69720.1 - 1.7 8.7 16.1 7.8 6.6 4.2 3.5 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Spc24 PF08286.6 ESS69720.1 - 5.9 6.6 12.9 4.2 7.1 0.4 3.3 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Aldedh PF00171.17 ESS69721.1 - 4.7e-82 275.7 0.0 5.9e-82 275.4 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ras PF00071.17 ESS69722.1 - 3.2e-38 130.6 0.0 3.9e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS69722.1 - 7.2e-20 71.6 0.0 2.1e-19 70.1 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESS69722.1 - 2.7e-15 56.0 0.0 7.7e-15 54.5 0.0 1.6 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESS69722.1 - 0.00071 19.5 0.0 0.0022 17.9 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase MobB PF03205.9 ESS69722.1 - 0.001 18.7 0.1 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 ESS69722.1 - 0.0016 17.8 0.1 0.0046 16.4 0.1 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.7 ESS69722.1 - 0.0066 15.6 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 ESS69722.1 - 0.061 12.0 0.1 0.84 8.2 0.0 2.2 1 1 1 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.13 ESS69722.1 - 0.15 11.2 0.3 0.87 8.8 0.2 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B DASH_Dam1 PF08653.5 ESS69723.1 - 0.05 13.3 6.0 7.3 6.4 0.0 4.3 4 1 1 5 5 5 0 DASH complex subunit Dam1 CSTF_C PF14304.1 ESS69723.1 - 0.88 8.9 8.2 0.04 13.1 1.7 1.8 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal Baculo_PEP_C PF04513.7 ESS69723.1 - 1.1 9.0 7.2 0.6 9.9 1.6 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.7 ESS69723.1 - 3.2 8.0 10.3 1.7 8.9 0.6 3.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_5 PF07728.9 ESS69724.1 - 9.8e-07 28.5 0.0 1.9e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESS69724.1 - 2.6e-06 27.4 0.0 4.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESS69724.1 - 4.4e-05 23.6 0.0 0.00045 20.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain Baculo_RING PF05883.6 ESS69724.1 - 0.00011 22.0 0.3 0.0002 21.2 0.2 1.4 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain AAA_16 PF13191.1 ESS69724.1 - 0.00026 21.0 0.3 0.01 15.8 0.0 3.2 3 1 0 4 4 3 1 AAA ATPase domain NACHT PF05729.7 ESS69724.1 - 0.01 15.5 0.0 0.033 13.8 0.0 1.9 1 1 0 1 1 1 0 NACHT domain AAA_25 PF13481.1 ESS69724.1 - 0.02 14.3 0.2 5.4 6.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.1 ESS69724.1 - 0.029 15.1 0.0 0.074 13.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.7 ESS69724.1 - 0.035 13.1 0.1 0.091 11.7 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 ESS69724.1 - 0.036 14.2 0.0 0.099 12.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 ESS69724.1 - 0.099 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Torsin PF06309.6 ESS69724.1 - 0.1 12.4 0.0 0.52 10.2 0.0 2.2 2 0 0 2 2 2 0 Torsin E2F_TDP PF02319.15 ESS69725.1 - 0.079 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain CRAL_TRIO PF00650.15 ESS69726.1 - 3e-25 88.5 0.0 4.3e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESS69726.1 - 2.4e-07 30.7 0.1 6.4e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 ESS69726.1 - 1.4e-05 25.0 0.0 3e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain Kelch_4 PF13418.1 ESS69727.1 - 2.3e-09 36.8 0.2 0.00031 20.4 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS69727.1 - 2.3e-05 24.4 3.3 0.12 12.6 0.0 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESS69727.1 - 0.00021 20.7 0.2 0.015 14.8 1.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.1 ESS69727.1 - 0.013 15.6 0.0 6.8 7.0 0.1 2.9 3 0 0 3 3 3 0 Kelch motif PH PF00169.24 ESS69728.1 - 6.7e-10 39.1 9.6 0.00016 21.8 1.3 3.8 2 2 0 2 2 2 2 PH domain PH_8 PF15409.1 ESS69728.1 - 6.2e-08 32.5 2.3 0.0029 17.6 0.2 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_10 PF15411.1 ESS69728.1 - 0.061 13.5 0.5 5 7.3 0.1 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.1 ESS69728.1 - 1.5 9.1 9.8 0.24 11.6 0.2 3.3 2 2 1 3 3 3 0 Pleckstrin homology domain DUF1796 PF08795.5 ESS69729.1 - 7.9e-55 185.0 0.0 1.1e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) Pkinase PF00069.20 ESS69730.1 - 9.7e-28 97.0 0.0 3.5e-11 42.7 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69730.1 - 3.9e-10 39.2 0.0 3.4e-05 23.0 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Nop14 PF04147.7 ESS69730.1 - 0.13 10.1 4.9 0.22 9.4 3.4 1.3 1 0 0 1 1 1 0 Nop14-like family PseudoU_synth_1 PF01416.15 ESS69731.1 - 1.1e-28 99.6 0.0 1.3e-18 67.3 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase Sigma70_r2 PF04542.9 ESS69733.1 - 0.022 14.3 0.0 4.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Sigma-70 region 2 Adaptin_N PF01602.15 ESS69734.1 - 6.7e-73 245.7 0.1 9.4e-73 245.3 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.1 ESS69734.1 - 1.3e-13 51.0 0.0 2.5e-12 46.9 0.0 2.6 2 0 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.2 ESS69734.1 - 1.1e-07 31.9 0.2 0.00026 20.8 0.1 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ESS69734.1 - 0.00044 20.4 2.5 1.7 9.0 0.2 3.9 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.17 ESS69734.1 - 0.017 15.1 0.2 4.7 7.5 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.1 ESS69734.1 - 0.028 14.9 1.5 1.8 9.1 0.0 3.9 4 0 0 4 4 4 0 HEAT-like repeat Cnd3 PF12719.2 ESS69734.1 - 0.032 13.2 0.1 0.092 11.7 0.0 1.8 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain Flavoprotein PF02441.14 ESS69735.1 - 1.2e-41 141.3 0.1 1.7e-41 140.8 0.1 1.2 1 0 0 1 1 1 1 Flavoprotein AAA PF00004.24 ESS69736.1 - 1.2e-13 51.4 0.0 4.2e-13 49.6 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESS69736.1 - 4.1e-06 26.5 0.0 9.2e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS69736.1 - 5.7e-06 26.4 0.1 1.3e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESS69736.1 - 2e-05 24.7 0.1 7.6e-05 22.8 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_17 PF13207.1 ESS69736.1 - 5.5e-05 23.9 0.0 0.00018 22.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS69736.1 - 9.6e-05 22.0 0.1 0.00028 20.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 ESS69736.1 - 0.00059 19.7 0.0 0.0014 18.5 0.0 1.7 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 ESS69736.1 - 0.00065 19.3 0.1 0.0016 18.0 0.1 1.9 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.1 ESS69736.1 - 0.0013 18.1 0.0 0.0045 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESS69736.1 - 0.003 17.8 0.0 0.0076 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESS69736.1 - 0.0039 17.0 0.0 0.0091 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESS69736.1 - 0.0043 16.1 0.0 0.011 14.8 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin UPF0079 PF02367.12 ESS69736.1 - 0.0046 16.5 0.0 0.0095 15.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 ESS69736.1 - 0.0049 16.8 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESS69736.1 - 0.0052 16.9 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 RNA helicase DUF815 PF05673.8 ESS69736.1 - 0.0061 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESS69736.1 - 0.0063 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 ESS69736.1 - 0.0069 15.9 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESS69736.1 - 0.015 14.7 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_23 PF13476.1 ESS69736.1 - 0.025 14.9 0.5 0.21 11.8 0.1 2.5 1 1 1 2 2 2 0 AAA domain Arch_ATPase PF01637.13 ESS69736.1 - 0.026 14.2 0.0 0.066 12.8 0.0 1.7 1 0 0 1 1 1 0 Archaeal ATPase AAA_30 PF13604.1 ESS69736.1 - 0.031 13.8 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESS69736.1 - 0.042 12.5 0.0 0.069 11.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus ABC_tran PF00005.22 ESS69736.1 - 0.052 13.8 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 ABC transporter cobW PF02492.14 ESS69736.1 - 0.064 12.6 0.3 0.19 11.1 0.1 1.8 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Torsin PF06309.6 ESS69736.1 - 0.076 12.9 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Torsin KaiC PF06745.8 ESS69736.1 - 0.083 11.9 0.0 0.18 10.8 0.0 1.6 1 0 0 1 1 1 0 KaiC Sigma54_activ_2 PF14532.1 ESS69736.1 - 0.099 12.6 0.0 0.31 11.0 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain Rad17 PF03215.10 ESS69736.1 - 0.1 11.2 0.0 0.25 9.9 0.0 1.6 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_24 PF13479.1 ESS69736.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 ESS69736.1 - 0.14 11.7 0.0 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 ESS69736.1 - 0.15 11.1 0.1 0.26 10.3 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.10 ESS69737.1 - 4.1e-07 29.0 0.0 0.00052 18.8 0.0 2.1 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 ESS69737.1 - 0.0035 17.3 0.0 0.0077 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESS69737.1 - 0.02 15.0 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ESS69737.1 - 0.054 12.3 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein PseudoU_synth_2 PF00849.17 ESS69738.1 - 1.3e-18 67.3 0.0 2.1e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase HD PF01966.17 ESS69739.1 - 3.4e-12 46.4 0.0 7.5e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 HD domain S1-P1_nuclease PF02265.11 ESS69740.1 - 1.1e-58 198.8 0.0 1.5e-58 198.3 0.0 1.2 1 0 0 1 1 1 1 S1/P1 Nuclease UPF0081 PF03652.10 ESS69740.1 - 0.11 12.5 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0081) DivIC PF04977.10 ESS69740.1 - 1.2 8.6 5.4 0.24 10.9 0.5 2.3 3 0 0 3 3 3 0 Septum formation initiator Kinesin PF00225.18 ESS69741.1 - 8.8e-81 271.1 0.0 1.8e-80 270.1 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Mcp5_PH PF12814.2 ESS69741.1 - 5.8e-05 22.9 0.0 0.00029 20.7 0.0 2.2 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology ApoO PF09769.4 ESS69741.1 - 0.48 10.1 2.9 16 5.1 0.3 2.7 1 1 1 2 2 2 0 Apolipoprotein O DUF1738 PF08401.6 ESS69742.1 - 0.015 15.0 0.1 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) WD40 PF00400.27 ESS69743.1 - 8.3e-30 101.5 12.6 2.1e-08 33.7 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESS69743.1 - 0.12 10.4 0.8 4.7 5.2 0.0 2.6 2 1 0 3 3 3 0 Nucleoporin Nup120/160 PSP1 PF04468.7 ESS69744.1 - 5.7e-17 61.4 0.0 9.5e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region RIO1 PF01163.17 ESS69745.1 - 1.9e-46 157.7 0.0 3.2e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 ESS69745.1 - 5.2e-32 109.7 0.3 1.5e-31 108.2 0.2 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 ESS69745.1 - 4e-09 36.5 0.5 0.00013 21.8 0.1 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 ESS69745.1 - 5.1e-06 25.6 0.8 0.00013 21.1 0.0 3.2 3 1 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESS69745.1 - 0.04 13.1 0.0 0.078 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Sdh_cyt PF01127.17 ESS69746.1 - 2.3 8.0 15.9 3.4 7.5 11.0 1.3 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fig1 PF12351.3 ESS69746.1 - 6.9 6.5 10.4 8.6 6.1 7.2 1.1 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 RabGAP-TBC PF00566.13 ESS69747.1 - 1.4e-37 129.2 1.5 1.5e-36 125.8 0.5 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain ABC_tran PF00005.22 ESS69749.1 - 1.3e-32 112.9 0.3 1.6e-17 64.0 0.0 3.3 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 ESS69749.1 - 1.1e-14 55.0 2.6 7.3e-05 22.8 0.1 4.0 4 0 0 4 4 4 3 AAA domain AAA_29 PF13555.1 ESS69749.1 - 2.9e-10 39.5 0.7 0.0002 20.8 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 ESS69749.1 - 2e-07 31.2 1.4 0.26 11.4 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_33 PF13671.1 ESS69749.1 - 9.2e-07 28.8 0.2 0.019 14.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 ESS69749.1 - 1.2e-06 29.0 0.0 0.016 15.7 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein SMC_N PF02463.14 ESS69749.1 - 3.8e-06 26.3 5.6 0.2 10.8 0.3 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESS69749.1 - 3.9e-06 27.3 0.1 0.022 15.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 ESS69749.1 - 6.7e-06 25.4 0.1 0.73 8.8 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain DUF258 PF03193.11 ESS69749.1 - 9.8e-06 24.8 0.1 0.088 11.9 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESS69749.1 - 1.6e-05 25.0 2.4 0.0053 16.7 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 ESS69749.1 - 1.7e-05 25.6 0.3 0.17 12.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 ESS69749.1 - 4.5e-05 23.1 0.4 0.043 13.5 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ESS69749.1 - 0.00015 21.3 3.0 0.15 11.5 0.0 3.4 4 0 0 4 4 3 1 AAA-like domain Zeta_toxin PF06414.7 ESS69749.1 - 0.00018 20.6 0.1 0.22 10.5 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 ESS69749.1 - 0.00025 20.5 0.0 0.24 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 ESS69749.1 - 0.00044 19.8 0.2 0.12 11.7 0.3 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 ESS69749.1 - 0.0005 20.0 0.1 0.15 12.0 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase SRP54 PF00448.17 ESS69749.1 - 0.00093 18.6 0.1 0.16 11.3 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Dynamin_N PF00350.18 ESS69749.1 - 0.0011 18.7 3.7 0.21 11.3 0.3 2.3 2 0 0 2 2 2 2 Dynamin family NACHT PF05729.7 ESS69749.1 - 0.0013 18.4 4.5 0.1 12.2 0.0 3.0 3 0 0 3 3 3 1 NACHT domain Arf PF00025.16 ESS69749.1 - 0.0015 17.7 0.0 0.3 10.3 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family ArgK PF03308.11 ESS69749.1 - 0.0024 16.6 0.1 0.39 9.4 0.0 2.3 2 0 0 2 2 2 1 ArgK protein G-alpha PF00503.15 ESS69749.1 - 0.0026 16.5 0.1 0.75 8.4 0.0 2.1 2 0 0 2 2 2 1 G-protein alpha subunit DUF3584 PF12128.3 ESS69749.1 - 0.0028 15.0 0.7 0.67 7.2 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) AAA_30 PF13604.1 ESS69749.1 - 0.0029 17.2 0.1 0.56 9.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain cobW PF02492.14 ESS69749.1 - 0.003 17.0 0.7 0.53 9.7 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 ESS69749.1 - 0.004 17.3 0.1 5.2 7.2 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESS69749.1 - 0.0041 17.0 0.4 3.5 7.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.4 ESS69749.1 - 0.0054 16.2 0.1 3.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arch_ATPase PF01637.13 ESS69749.1 - 0.0063 16.2 0.3 0.89 9.2 0.0 3.0 3 0 0 3 3 3 1 Archaeal ATPase DUF815 PF05673.8 ESS69749.1 - 0.007 15.3 1.3 0.54 9.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 ESS69749.1 - 0.0078 16.1 0.2 2.7 7.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 ESS69749.1 - 0.0087 15.5 0.0 1.3 8.4 0.0 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain VirE PF05272.6 ESS69749.1 - 0.012 15.0 0.1 0.32 10.4 0.0 2.2 2 0 0 2 2 2 0 Virulence-associated protein E Mg_chelatase PF01078.16 ESS69749.1 - 0.019 14.1 0.8 1.2 8.2 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MutS_V PF00488.16 ESS69749.1 - 0.019 14.3 0.2 1.7 7.9 0.0 2.7 3 0 0 3 3 3 0 MutS domain V AAA_19 PF13245.1 ESS69749.1 - 0.022 14.5 0.3 0.85 9.4 0.2 2.6 2 0 0 2 2 2 0 Part of AAA domain T2SE PF00437.15 ESS69749.1 - 0.029 13.2 0.1 1.5 7.6 0.1 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.1 ESS69749.1 - 0.03 13.9 0.1 4.4 6.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 ESS69749.1 - 0.044 13.8 0.0 1.5 8.8 0.0 2.7 3 1 0 3 3 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 ESS69749.1 - 0.048 13.9 0.3 15 5.9 0.0 2.6 3 0 0 3 3 2 0 AAA domain MCM PF00493.18 ESS69749.1 - 0.05 12.3 0.1 8.2 5.1 0.0 2.2 2 0 0 2 2 2 0 MCM2/3/5 family AAA_5 PF07728.9 ESS69749.1 - 0.054 13.2 0.8 1.6 8.4 0.0 2.8 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 ESS69749.1 - 0.066 12.2 0.0 3 6.8 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Gtr1_RagA PF04670.7 ESS69749.1 - 0.08 12.0 1.3 2.4 7.2 0.1 2.3 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region RNA_helicase PF00910.17 ESS69749.1 - 0.087 13.0 0.3 12 6.1 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Septin PF00735.13 ESS69749.1 - 0.092 11.7 0.4 6.9 5.6 0.0 2.2 2 0 0 2 2 2 0 Septin GTP_EFTU PF00009.22 ESS69749.1 - 0.13 11.6 0.1 0.71 9.2 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Sigma54_activat PF00158.21 ESS69749.1 - 0.14 11.6 0.2 11 5.4 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain AIG1 PF04548.11 ESS69749.1 - 0.17 10.9 0.6 6.3 5.8 0.0 2.5 2 0 0 2 2 2 0 AIG1 family AAA_13 PF13166.1 ESS69749.1 - 0.2 10.0 1.2 1.9 6.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 ESS69749.1 - 0.22 11.2 0.4 11 5.6 0.0 2.7 3 0 0 3 3 2 0 NTPase ATP_bind_1 PF03029.12 ESS69749.1 - 1.1 8.7 3.4 5.1 6.5 0.2 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DAP3 PF10236.4 ESS69749.1 - 1.3 7.8 2.8 6.1 5.6 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.17 ESS69749.1 - 3.8 6.2 7.2 3.2 6.5 0.4 3.1 3 1 0 3 3 2 0 NB-ARC domain Epimerase PF01370.16 ESS69752.1 - 9.2e-19 67.8 0.0 1.2e-18 67.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESS69752.1 - 5.7e-11 41.8 0.0 7.7e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESS69752.1 - 1.7e-06 27.2 0.1 3.6e-05 22.8 0.1 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESS69752.1 - 2.9e-06 26.2 0.0 3.7e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 ESS69752.1 - 4.2e-05 22.6 0.0 0.00026 19.9 0.0 1.9 1 1 1 2 2 2 1 Male sterility protein adh_short PF00106.20 ESS69752.1 - 0.0044 16.9 0.0 0.0085 16.0 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESS69752.1 - 0.074 12.7 0.0 0.15 11.7 0.0 1.5 1 1 0 1 1 1 0 KR domain Brix PF04427.13 ESS69753.1 - 1.2e-43 149.0 0.3 1.5e-43 148.6 0.2 1.1 1 0 0 1 1 1 1 Brix domain Clathrin PF00637.15 ESS69754.1 - 9.6e-13 47.9 2.1 1.6e-11 44.0 0.8 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 ESS69754.1 - 0.0051 16.6 3.4 0.01 15.6 2.4 1.6 1 0 0 1 1 1 1 Ring finger domain LysM PF01476.15 ESS69754.1 - 0.012 15.5 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 LysM domain zf-C3HC4_2 PF13923.1 ESS69754.1 - 0.046 13.7 0.9 0.046 13.7 0.6 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS69754.1 - 3.6 7.3 6.9 9.1 6.0 4.8 1.7 1 1 0 1 1 1 0 zinc-RING finger domain CH PF00307.26 ESS69756.1 - 0.064 13.2 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 Calponin homology (CH) domain Filament PF00038.16 ESS69756.1 - 0.58 9.5 31.5 1.5 8.2 17.7 2.8 1 1 1 2 2 2 0 Intermediate filament protein ArsC PF03960.10 ESS69756.1 - 2.9 8.0 8.0 1.6 8.8 0.4 2.6 1 1 0 2 2 2 0 ArsC family DUF3584 PF12128.3 ESS69756.1 - 3.2 4.9 27.3 5.1 4.2 18.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TMF_DNA_bd PF12329.3 ESS69756.1 - 4.4 7.1 38.7 0.031 14.0 2.2 5.3 5 0 0 5 5 5 0 TATA element modulatory factor 1 DNA binding Phos_pyr_kin PF08543.7 ESS69759.1 - 2.2e-15 56.5 0.0 3.3e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 ESS69759.1 - 6.5e-12 45.1 1.2 1.5e-10 40.7 0.4 2.6 2 1 0 2 2 2 1 pfkB family carbohydrate kinase FYVE PF01363.16 ESS69760.1 - 0.04 13.8 16.6 0.095 12.6 11.5 1.7 1 0 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.11 ESS69760.1 - 0.57 10.0 16.8 6.2 6.7 11.7 2.1 1 1 1 2 2 2 0 FYVE-type zinc finger EF-hand_7 PF13499.1 ESS69762.1 - 0.00012 22.1 0.5 0.0012 18.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS69762.1 - 0.00044 19.8 0.1 0.0033 17.1 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESS69762.1 - 0.00086 18.4 0.3 0.0087 15.3 0.1 2.7 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 ESS69762.1 - 0.017 14.4 0.5 0.041 13.2 0.3 1.7 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.1 ESS69762.1 - 0.027 14.1 0.3 0.22 11.1 0.1 2.4 3 0 0 3 3 3 0 EF-hand domain pair zf-C3HC4_3 PF13920.1 ESS69763.1 - 1.1e-06 28.1 9.8 1.1e-06 28.1 6.8 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS69763.1 - 0.014 15.3 13.4 0.014 15.3 9.3 3.7 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS69763.1 - 0.017 14.9 12.9 0.017 14.9 9.0 3.4 2 1 0 2 2 2 0 Ring finger domain AAA_28 PF13521.1 ESS69764.1 - 6.5e-26 91.2 0.0 1.3e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS69764.1 - 0.0014 19.4 0.0 0.0059 17.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 ESS69764.1 - 0.014 14.1 0.0 0.028 13.2 0.0 1.4 1 0 0 1 1 1 0 ArgK protein DAP3 PF10236.4 ESS69764.1 - 0.016 14.1 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_18 PF13238.1 ESS69764.1 - 0.022 15.0 0.0 0.075 13.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 ESS69764.1 - 0.024 13.8 0.0 0.058 12.5 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 UCH PF00443.24 ESS69765.1 - 1.3e-39 135.9 0.0 1.7e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS69765.1 - 3e-09 36.7 5.1 5.9e-09 35.7 0.7 2.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 ESS69765.1 - 0.06 13.4 3.2 0.2 11.7 0.2 3.2 3 0 0 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein NUDIX PF00293.23 ESS69766.1 - 2.3e-15 56.4 0.1 5e-15 55.3 0.1 1.5 1 1 0 1 1 1 1 NUDIX domain NUDIX PF00293.23 ESS69767.1 - 1.8e-15 56.7 0.1 3.9e-15 55.6 0.1 1.5 1 1 0 1 1 1 1 NUDIX domain MA3 PF02847.12 ESS69769.1 - 2.8e-08 33.4 0.1 1.1e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 MA3 domain DUF1675 PF07897.6 ESS69769.1 - 5.6 6.7 12.4 13 5.5 8.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1675) Arm PF00514.18 ESS69770.1 - 6.2e-62 203.5 18.8 6.1e-10 38.5 0.0 9.0 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 ESS69770.1 - 5.5e-18 64.9 5.5 0.00014 22.2 0.0 6.0 5 1 2 7 7 7 4 HEAT-like repeat HEAT_2 PF13646.1 ESS69770.1 - 1.2e-17 63.9 1.1 0.023 14.9 0.1 5.8 2 1 3 6 6 6 5 HEAT repeats HEAT PF02985.17 ESS69770.1 - 2.8e-11 42.5 2.3 0.22 11.6 0.0 7.4 8 0 0 8 8 8 2 HEAT repeat Proteasom_PSMB PF10508.4 ESS69770.1 - 0.0014 17.0 0.1 0.0065 14.8 0.0 1.8 1 1 1 2 2 2 2 Proteasome non-ATPase 26S subunit HSP33 PF01430.14 ESS69771.1 - 1.7e-11 43.7 0.8 3.2e-05 23.1 0.2 3.3 3 1 0 3 3 3 3 Hsp33 protein Actin PF00022.14 ESS69773.1 - 0.00056 18.4 0.0 0.00097 17.6 0.0 1.3 1 0 0 1 1 1 1 Actin SSP160 PF06933.6 ESS69773.1 - 0.97 7.3 7.7 1.6 6.5 5.4 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 BaxI_1 PF12811.2 ESS69774.1 - 0.017 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Bax inhibitor 1 like RRM_1 PF00076.17 ESS69775.1 - 3e-33 113.2 0.0 5.9e-10 38.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69775.1 - 5.7e-25 87.0 0.0 3e-09 36.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69775.1 - 7.8e-19 67.2 0.1 1.5e-06 27.9 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESS69775.1 - 0.0096 15.7 0.0 2.8 7.8 0.0 2.4 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.1 ESS69775.1 - 0.078 12.7 0.2 0.95 9.2 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DREV PF05219.7 ESS69776.1 - 2.9e-61 206.6 0.0 3.4e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.1 ESS69776.1 - 4.4e-09 36.2 0.0 6.5e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS69776.1 - 2.5e-07 31.0 0.0 5.3e-07 30.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS69776.1 - 0.0035 17.7 0.0 0.0077 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS69776.1 - 0.0088 16.6 0.0 0.056 14.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.15 ESS69776.1 - 0.024 13.6 0.1 0.068 12.1 0.0 1.6 1 1 1 2 2 2 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.1 ESS69776.1 - 0.11 12.0 0.0 4.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Sdh5 PF03937.11 ESS69777.1 - 2e-21 75.4 0.1 3.4e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase RF-1 PF00472.15 ESS69778.1 - 5.6e-14 51.9 0.3 8.6e-14 51.3 0.2 1.2 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.4 ESS69778.1 - 0.0015 18.6 0.0 0.0021 18.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein DnaJ PF00226.26 ESS69779.1 - 9.6e-20 70.0 0.4 2.1e-19 68.9 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain DUF3353 PF11833.3 ESS69779.1 - 2.7 7.4 4.4 1.6 8.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) Ufd2P_core PF10408.4 ESS69781.1 - 3.1e-129 432.0 0.0 4.5e-129 431.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core Thioredoxin PF00085.15 ESS69781.1 - 5.2e-19 67.8 0.0 1.5e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESS69781.1 - 0.001 19.1 0.0 0.0047 17.0 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.5 ESS69781.1 - 0.0073 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 ESS69781.1 - 0.017 14.8 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.1 ESS69781.1 - 0.03 14.3 0.1 0.09 12.8 0.1 1.8 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.1 ESS69781.1 - 0.037 14.2 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain T2SF PF00482.18 ESS69781.1 - 0.053 13.4 0.3 29 4.6 0.0 3.4 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F Pkinase PF00069.20 ESS69782.1 - 4.1e-40 137.5 0.0 6.3e-39 133.6 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69782.1 - 2e-21 76.2 0.0 2.5e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESS69782.1 - 0.013 15.2 0.1 0.057 13.1 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS69782.1 - 0.028 13.3 0.4 0.37 9.7 0.0 2.1 1 1 1 2 2 2 0 Kinase-like Mo25 PF08569.6 ESS69783.1 - 2.3e-81 273.4 0.0 2.6e-81 273.2 0.0 1.0 1 0 0 1 1 1 1 Mo25-like HEAT PF02985.17 ESS69783.1 - 0.011 15.8 0.1 3.5 7.9 0.0 3.0 2 0 0 2 2 2 0 HEAT repeat APG5 PF04106.7 ESS69784.1 - 0.046 13.1 0.0 11 5.4 0.0 2.7 3 0 0 3 3 3 0 Autophagy protein Apg5 Spc97_Spc98 PF04130.8 ESS69785.1 - 7.4e-35 120.2 0.1 5.2e-16 58.0 0.0 2.8 2 1 0 2 2 2 2 Spc97 / Spc98 family DUF4139 PF13598.1 ESS69786.1 - 7.2e-98 327.7 0.5 1.1e-97 327.1 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.1 ESS69786.1 - 2.9e-12 46.9 2.7 2.9e-12 46.9 1.8 2.2 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) DUF3053 PF11254.3 ESS69786.1 - 0.012 14.8 1.6 0.027 13.7 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) DUF1929 PF09118.6 ESS69786.1 - 2.1 8.4 5.2 4.7 7.3 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1929) PPK2 PF03976.9 ESS69787.1 - 0.047 12.9 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) HECT PF00632.20 ESS69788.1 - 1.5e-77 260.8 0.0 2.4e-77 260.2 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PfkB PF00294.19 ESS69790.1 - 7e-61 205.9 0.0 8.4e-61 205.7 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 ESS69790.1 - 0.083 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Epimerase PF01370.16 ESS69791.1 - 7.5e-29 100.8 0.0 9.5e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 ESS69791.1 - 0.00069 18.6 0.0 0.00089 18.2 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein MMR_HSR1 PF01926.18 ESS69792.1 - 2.8e-09 36.9 0.0 1.2e-07 31.6 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESS69792.1 - 5.2e-06 26.3 0.0 0.00014 21.7 0.0 2.4 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 ESS69792.1 - 3e-05 23.5 0.0 6.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESS69792.1 - 7.2e-05 22.1 0.3 1 8.6 0.1 4.1 5 0 0 5 5 5 2 Ferrous iron transport protein B ATP_bind_1 PF03029.12 ESS69792.1 - 0.00031 20.3 0.0 0.016 14.7 0.0 2.8 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein DUF258 PF03193.11 ESS69792.1 - 0.0088 15.2 0.0 0.031 13.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 DUF3736 PF12540.3 ESS69792.1 - 0.075 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3736) EST1 PF10374.4 ESS69793.1 - 0.12 12.3 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Telomerase activating protein Est1 DUF3287 PF11690.3 ESS69794.1 - 0.11 12.5 1.3 0.13 12.3 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Methyltransf_PK PF05891.7 ESS69795.1 - 2.4e-62 210.1 0.0 3e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_11 PF08241.7 ESS69795.1 - 2.9e-08 34.0 0.0 4.9e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS69795.1 - 6.5e-05 23.3 0.0 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS69795.1 - 0.00014 22.1 0.0 0.00025 21.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS69795.1 - 0.00081 19.0 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS69795.1 - 0.001 18.7 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS69795.1 - 0.0015 19.0 0.0 0.0028 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESS69795.1 - 0.0066 15.6 0.0 0.0072 15.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.9 ESS69795.1 - 0.092 12.1 0.0 0.28 10.5 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase small domain Pkinase PF00069.20 ESS69796.1 - 1.2e-69 234.4 0.0 1.6e-69 233.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69796.1 - 3.5e-29 101.6 0.0 4.8e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 ESS69796.1 - 1.4e-08 34.8 0.0 3.5e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 ESS69796.1 - 2.5e-05 24.4 0.6 0.00015 22.0 0.4 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.1 ESS69796.1 - 0.0017 17.4 0.0 0.0034 16.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESS69796.1 - 0.008 15.2 0.1 0.024 13.6 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Arm PF00514.18 ESS69799.1 - 1.4e-22 78.6 18.9 0.083 12.7 0.0 12.4 14 0 0 14 14 14 7 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 ESS69799.1 - 1.7e-09 37.3 12.6 0.2 11.3 0.0 8.2 4 3 4 9 9 9 4 Spinocerebellar ataxia type 10 protein domain CH PF00307.26 ESS69799.1 - 0.0037 17.2 0.2 0.019 15.0 0.1 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain V-ATPase_H_C PF11698.3 ESS69799.1 - 0.024 14.5 0.9 8.7 6.2 0.0 3.9 4 0 0 4 4 4 0 V-ATPase subunit H Lactamase_B PF00753.22 ESS69800.1 - 3.9e-09 36.4 0.0 1.7e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESS69800.1 - 6.7e-05 22.5 0.0 9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DJ-1_PfpI PF01965.19 ESS69801.1 - 1.2e-25 89.6 0.0 1.7e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 ESS69801.1 - 8.5e-11 41.4 0.0 1.1e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase Keratin_assoc PF09775.4 ESS69801.1 - 0.2 11.1 2.6 2.6 7.5 0.0 2.7 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 DUF1664 PF07889.7 ESS69803.1 - 1.8 8.3 19.6 0.42 10.4 1.3 4.2 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) DASH_Dam1 PF08653.5 ESS69803.1 - 4.3 7.1 10.0 4.6 7.0 0.6 3.9 5 0 0 5 5 5 0 DASH complex subunit Dam1 Kinesin PF00225.18 ESS69804.1 - 4.2e-83 278.8 0.0 1.7e-82 276.8 0.0 2.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 ESS69804.1 - 0.037 14.1 0.0 1.5 8.9 0.0 3.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 ESS69804.1 - 0.039 13.9 0.0 0.53 10.2 0.0 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase FYVE PF01363.16 ESS69829.1 - 1.6e-21 75.9 2.4 1.6e-21 75.9 1.7 2.1 2 0 0 2 2 2 1 FYVE zinc finger Nnf1 PF03980.9 ESS69829.1 - 0.04 13.9 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Nnf1 Ras PF00071.17 ESS69830.1 - 5.3e-10 38.9 0.0 0.00068 19.0 0.0 3.0 2 1 0 3 3 3 2 Ras family Miro PF08477.8 ESS69830.1 - 6.7e-06 26.6 0.0 0.21 12.1 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein Arf PF00025.16 ESS69830.1 - 0.00063 19.0 0.0 0.98 8.6 0.0 2.5 3 0 0 3 3 3 2 ADP-ribosylation factor family Scm3 PF10384.4 ESS69831.1 - 1.2 8.7 4.7 0.43 10.0 0.2 2.4 2 0 0 2 2 2 0 Centromere protein Scm3 HSP70 PF00012.15 ESS69833.1 - 2.4e-167 557.5 0.2 2.7e-167 557.3 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESS69833.1 - 6.4e-13 47.9 0.0 1.1e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein DDR PF08841.5 ESS69833.1 - 0.027 13.3 0.3 3.5 6.3 0.1 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.6 ESS69833.1 - 0.039 12.8 0.1 0.18 10.7 0.0 1.9 1 1 0 2 2 2 0 StbA protein Hydantoinase_A PF01968.13 ESS69833.1 - 0.056 12.5 0.4 1.3 8.0 0.2 2.3 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DUF1464 PF07318.7 ESS69833.1 - 0.058 12.1 0.0 0.099 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) PTCB-BRCT PF12738.2 ESS69835.1 - 1.2e-11 44.3 0.1 2.8e-08 33.5 0.1 2.8 2 0 0 2 2 2 2 twin BRCT domain BRCT PF00533.21 ESS69835.1 - 5.2e-06 26.5 0.0 0.054 13.6 0.0 3.5 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain LRR_4 PF12799.2 ESS69836.1 - 3.7e-15 55.1 9.1 6.8e-05 22.3 2.8 4.6 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS69836.1 - 1.4e-14 53.5 7.5 1.8e-05 24.3 3.5 3.8 3 1 0 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESS69836.1 - 9.5e-08 31.0 11.6 0.22 11.6 0.2 7.1 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS69836.1 - 1.4e-05 24.6 14.5 0.04 13.9 1.2 5.3 4 1 1 5 5 5 3 Leucine Rich repeat LRR_7 PF13504.1 ESS69836.1 - 4.7e-05 22.9 12.6 0.4 11.0 0.2 6.4 6 0 0 6 6 6 2 Leucine rich repeat DnaJ PF00226.26 ESS69837.1 - 4.3e-21 74.4 0.3 8.1e-21 73.5 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESS69837.1 - 1.6e-05 24.2 0.0 4.8e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 X-domain of DnaJ-containing NUP50 PF08911.6 ESS69837.1 - 1.4 9.3 4.8 42 4.6 2.3 3.1 3 0 0 3 3 3 0 NUP50 (Nucleoporin 50 kDa) zf-DHHC PF01529.15 ESS69837.1 - 4.5 6.6 5.1 9.2 5.6 3.6 1.6 1 1 0 1 1 1 0 DHHC palmitoyltransferase Nucleoplasmin PF03066.10 ESS69839.1 - 0.0028 17.1 9.9 0.31 10.5 2.5 2.3 2 0 0 2 2 2 2 Nucleoplasmin Beta_helix PF13229.1 ESS69839.1 - 0.065 12.9 0.0 1.2 8.9 0.0 2.4 1 1 0 1 1 1 0 Right handed beta helix region CENP-B_dimeris PF09026.5 ESS69839.1 - 0.37 11.0 15.5 0.24 11.6 0.7 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Rad54_N PF08658.5 ESS69839.1 - 2.1 8.0 8.4 0.94 9.2 0.7 2.3 2 0 0 2 2 2 0 Rad54 N terminal PBP1_TM PF14812.1 ESS69839.1 - 3 8.1 11.8 1.5 9.1 2.1 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Merozoite_SPAM PF07133.6 ESS69839.1 - 4.1 7.2 20.5 3.8 7.3 4.8 2.2 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) SIT PF15330.1 ESS69840.1 - 0.0088 16.1 0.2 0.0088 16.1 0.2 2.0 2 0 0 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT DUF1517 PF07466.6 ESS69840.1 - 0.02 13.8 3.6 0.019 13.9 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) MSC PF09402.5 ESS69840.1 - 0.024 13.3 0.5 0.03 13.0 0.4 1.0 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Phage_F PF02305.12 ESS69840.1 - 0.039 12.5 1.5 0.039 12.4 1.0 1.0 1 0 0 1 1 1 0 Capsid protein (F protein) Plasmodium_Vir PF05795.6 ESS69840.1 - 0.19 10.9 2.1 0.2 10.8 1.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DIM PF08194.7 ESS69840.1 - 0.35 10.8 1.9 0.47 10.4 1.3 1.2 1 0 0 1 1 1 0 DIM protein DUF508 PF04370.7 ESS69840.1 - 0.77 9.3 9.4 0.87 9.2 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Macoilin PF09726.4 ESS69840.1 - 1.6 6.9 6.5 1.6 6.9 4.5 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF3633 PF12315.3 ESS69840.1 - 7.9 5.7 8.1 8.9 5.5 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) PseudoU_synth_2 PF00849.17 ESS69841.1 - 3.7e-15 56.1 0.0 6.5e-13 48.8 0.0 3.0 1 1 0 1 1 1 1 RNA pseudouridylate synthase SpoVR PF04293.8 ESS69844.1 - 6 5.1 7.6 6.5 5.0 5.3 1.0 1 0 0 1 1 1 0 SpoVR like protein Herpes_DNAp_acc PF04929.7 ESS69844.1 - 6.5 5.6 10.1 6.9 5.5 7.0 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor GreA_GreB_N PF03449.10 ESS69845.1 - 0.025 14.6 0.7 2.2 8.3 0.0 2.5 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal DUF3646 PF12362.3 ESS69845.1 - 0.078 12.9 0.4 0.33 10.9 0.1 2.2 2 0 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal LSM14 PF12701.2 ESS69847.1 - 0.00089 19.0 0.4 0.0023 17.7 0.3 1.7 1 0 0 1 1 1 1 Scd6-like Sm domain Ax_dynein_light PF10211.4 ESS69848.1 - 1.7e-57 194.3 8.7 1.7e-57 194.3 6.0 1.5 2 0 0 2 2 2 1 Axonemal dynein light chain Seryl_tRNA_N PF02403.17 ESS69848.1 - 0.018 15.0 10.1 0.053 13.5 7.0 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Reo_sigmaC PF04582.7 ESS69848.1 - 0.027 13.6 0.1 0.046 12.8 0.0 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein AKNA PF12443.3 ESS69848.1 - 0.14 12.2 3.2 0.17 11.9 1.0 2.1 2 0 0 2 2 2 0 AT-hook-containing transcription factor bZIP_1 PF00170.16 ESS69848.1 - 3.2 7.7 16.7 0.3 11.0 2.4 3.0 2 1 1 3 3 3 0 bZIP transcription factor TROVE PF05731.6 ESS69849.1 - 2.8e-53 181.0 0.0 2.4e-50 171.4 0.0 2.3 1 1 0 1 1 1 1 TROVE domain WD40 PF00400.27 ESS69849.1 - 1.4e-32 110.3 17.3 5.7e-06 26.0 0.1 10.9 11 0 0 11 11 11 8 WD domain, G-beta repeat DUF4062 PF13271.1 ESS69849.1 - 2.3e-05 24.3 0.1 0.0002 21.3 0.0 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4062) RRM_1 PF00076.17 ESS69853.1 - 4.8e-10 38.9 0.0 8.5e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69853.1 - 7.9e-07 28.9 0.0 1.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69853.1 - 1e-06 28.5 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Btz PF09405.5 ESS69853.1 - 0.055 13.5 0.0 0.097 12.7 0.0 1.5 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding Herpes_UL3 PF03369.8 ESS69855.1 - 0.11 12.4 4.5 0.084 12.8 0.6 2.6 2 0 0 2 2 2 0 Herpesvirus UL3 protein FAA_hydrolase_N PF09298.6 ESS69855.1 - 6.9 6.7 20.9 6.3 6.8 0.3 4.6 3 1 0 4 4 4 0 Fumarylacetoacetase N-terminal Strabismus PF06638.6 ESS69856.1 - 3.5 5.8 5.3 4.5 5.4 3.7 1.1 1 0 0 1 1 1 0 Strabismus protein Aldo_ket_red PF00248.16 ESS69857.1 - 0.0012 17.6 0.0 0.0073 15.1 0.0 2.2 2 1 0 2 2 2 1 Aldo/keto reductase family Dynein_heavy PF03028.10 ESS69858.1 - 4.5e-193 643.1 0.1 2.4e-192 640.7 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESS69858.1 - 2.8e-118 394.9 10.4 2.8e-118 394.9 7.2 2.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS69858.1 - 2.9e-95 318.1 0.0 5.9e-95 317.1 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESS69858.1 - 6.6e-68 228.5 0.0 2.7e-67 226.5 0.0 2.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS69858.1 - 2.2e-56 190.2 0.2 6.9e-56 188.6 0.2 1.9 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS69858.1 - 6.3e-53 179.7 6.2 1.2e-52 178.7 4.3 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESS69858.1 - 1.3e-32 112.9 0.0 3.2e-32 111.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESS69858.1 - 4.8e-21 74.9 0.0 5.1e-07 29.5 0.0 5.4 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESS69858.1 - 2e-06 27.9 0.2 0.83 9.6 0.0 5.5 4 1 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.1 ESS69858.1 - 8.8e-06 25.8 0.1 1.6 8.8 0.0 5.0 4 0 0 4 4 4 2 AAA domain AAA PF00004.24 ESS69858.1 - 6.6e-05 23.1 0.2 1.3 9.1 0.0 4.8 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 ESS69858.1 - 0.00056 19.5 0.5 0.74 9.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 ESS69858.1 - 0.01 16.6 0.1 18 6.1 0.0 4.8 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.1 ESS69858.1 - 0.012 15.3 1.2 5.1 6.9 0.0 3.9 3 0 0 3 3 3 0 Part of AAA domain FtsK_SpoIIIE PF01580.13 ESS69858.1 - 0.027 13.9 0.0 0.027 13.9 0.0 3.4 4 0 0 4 4 4 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 ESS69858.1 - 0.04 14.0 0.0 6.6 6.9 0.0 3.6 3 0 0 3 3 3 0 RNA helicase DcpS_C PF11969.3 ESS69859.1 - 9.4e-07 29.0 0.0 2.2e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-P11 PF03854.9 ESS69859.1 - 0.83 9.1 6.0 0.28 10.7 1.2 2.2 1 1 1 2 2 2 0 P-11 zinc finger PRKCSH-like PF12999.2 ESS69861.1 - 7.2e-36 123.3 7.4 7.2e-36 123.3 5.2 2.4 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 ESS69861.1 - 6.4e-20 71.1 0.1 2.1e-19 69.5 0.1 1.9 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 ESS69861.1 - 5.8e-08 33.4 1.7 5.8e-08 33.4 1.1 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein DUF2252 PF10009.4 ESS69861.1 - 5.8 5.6 7.8 9.9 4.9 5.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Uds1 PF15456.1 ESS69861.1 - 6.8 6.6 14.8 18 5.3 0.2 2.5 2 0 0 2 2 2 0 Up-regulated During Septation Tic20 PF09685.5 ESS69862.1 - 0.054 13.4 0.9 0.13 12.2 0.1 1.9 2 0 0 2 2 2 0 Tic20-like protein PKD_channel PF08016.7 ESS69863.1 - 3.6e-10 38.8 10.3 4.4e-10 38.5 7.2 1.0 1 0 0 1 1 1 1 Polycystin cation channel Pkinase PF00069.20 ESS69864.1 - 4e-32 111.3 0.0 1.4e-31 109.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS69864.1 - 1.5e-11 43.9 0.0 2.4e-05 23.5 0.0 2.7 3 1 0 3 3 3 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESS69864.1 - 0.43 9.3 0.1 0.62 8.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3278 PF11683.3 ESS69865.1 - 6.4 6.7 10.1 8.7 6.3 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) DUF3488 PF11992.3 ESS69865.1 - 9.7 4.7 7.7 6 5.4 4.4 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3488) Tmp39 PF10271.4 ESS69866.1 - 0.62 8.6 3.1 0.67 8.5 2.1 1.0 1 0 0 1 1 1 0 Putative transmembrane protein DUF4131 PF13567.1 ESS69866.1 - 2.3 7.5 6.4 3.1 7.1 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) NMD3 PF04981.8 ESS69867.1 - 5.8e-73 244.8 5.2 7.7e-73 244.4 3.6 1.2 1 0 0 1 1 1 1 NMD3 family Acyl-CoA_ox_N PF14749.1 ESS69867.1 - 0.032 14.5 1.8 0.064 13.5 1.0 1.7 1 1 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal zf-TFIIB PF13453.1 ESS69867.1 - 7.7 5.8 8.2 2.8 7.1 1.2 2.6 2 0 0 2 2 2 0 Transcription factor zinc-finger Glycoamylase PF10091.4 ESS69868.1 - 0.057 12.4 0.0 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 Putative glucoamylase Mcp5_PH PF12814.2 ESS69869.1 - 6.1e-13 48.7 0.0 1.2e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF3395 PF11875.3 ESS69870.1 - 9e-49 164.9 0.0 2.1e-48 163.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.26 ESS69870.1 - 1.9e-15 56.3 0.2 5.6e-15 54.8 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain PIF1 PF05970.9 ESS69871.1 - 1.6e-05 24.0 0.0 5.1e-05 22.3 0.0 1.8 2 1 0 2 2 2 1 PIF1-like helicase AAA_30 PF13604.1 ESS69871.1 - 0.015 14.8 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 ESS69871.1 - 0.024 14.0 0.0 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DZR PF12773.2 ESS69871.1 - 0.025 14.3 4.3 2.1 8.2 3.5 2.7 1 1 1 2 2 2 0 Double zinc ribbon Phenol_monoox PF04663.7 ESS69871.1 - 0.027 14.2 0.0 1.4 8.7 0.0 2.7 2 0 0 2 2 2 0 Phenol hydroxylase conserved region DUF164 PF02591.10 ESS69871.1 - 0.028 14.2 2.2 0.14 11.9 0.8 2.4 2 0 0 2 2 2 0 Putative zinc ribbon domain IstB_IS21 PF01695.12 ESS69871.1 - 0.13 11.6 0.0 0.33 10.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2391 PF09622.5 ESS69871.1 - 0.17 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Putative integral membrane protein (DUF2391) T2SE PF00437.15 ESS69871.1 - 0.19 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3505 PF12013.3 ESS69871.1 - 0.64 10.2 5.7 1.1 9.4 0.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3505) Nop14 PF04147.7 ESS69871.1 - 0.69 7.7 4.4 0.97 7.2 3.0 1.1 1 0 0 1 1 1 0 Nop14-like family HSP70 PF00012.15 ESS69872.1 - 6.9e-77 258.7 0.1 2.5e-76 256.9 0.0 1.8 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESS69872.1 - 4.5e-05 22.2 0.0 0.0023 16.6 0.0 2.9 2 1 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 ESS69872.1 - 0.0013 18.4 0.0 0.0035 16.9 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 ESS69872.1 - 0.0096 14.7 0.0 1.9 7.2 0.0 2.4 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.1 ESS69872.1 - 0.087 12.6 0.0 21 4.9 0.0 3.1 3 1 0 3 3 3 0 Cell division protein FtsA FYRC PF05965.9 ESS69873.1 - 0.00052 19.7 0.0 0.0014 18.3 0.0 1.7 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.9 ESS69873.1 - 0.027 13.9 0.0 0.054 12.9 0.0 1.5 1 0 0 1 1 1 0 F/Y-rich N-terminus Exo_endo_phos PF03372.18 ESS69874.1 - 6.1e-15 55.8 0.1 1e-14 55.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family XRN_N PF03159.13 ESS69874.1 - 0.0025 17.2 0.0 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus IF3_N PF05198.11 ESS69875.1 - 0.0013 18.6 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain Nuc-transf PF10127.4 ESS69875.1 - 0.07 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Predicted nucleotidyltransferase Curto_V2 PF07325.6 ESS69875.1 - 0.1 12.2 0.1 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Curtovirus V2 protein WW PF00397.21 ESS69876.1 - 1.3e-08 34.5 2.1 2.5e-08 33.6 1.5 1.5 1 0 0 1 1 1 1 WW domain SDA1 PF05285.7 ESS69877.1 - 2.8 7.1 17.8 4.2 6.5 12.3 1.2 1 0 0 1 1 1 0 SDA1 AsnA PF03590.10 ESS69878.1 - 4.5e-101 337.3 0.1 8.3e-100 333.2 0.0 2.0 1 1 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.15 ESS69878.1 - 0.00099 17.9 0.1 0.05 12.3 0.0 2.2 2 1 0 2 2 2 2 tRNA synthetases class II (D, K and N) TPR_2 PF07719.12 ESS69880.1 - 0.11 12.4 1.1 35 4.6 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat RCC1 PF00415.13 ESS69882.1 - 1e-60 201.7 39.2 2e-12 47.0 0.2 12.1 13 0 0 13 13 13 9 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS69882.1 - 4.2e-46 153.6 54.0 2.1e-08 33.5 0.2 11.4 11 0 0 11 11 11 10 Regulator of chromosome condensation (RCC1) repeat CBM_X PF06204.6 ESS69882.1 - 0.016 14.6 0.7 8.4 5.9 0.0 3.5 3 0 0 3 3 3 0 Putative carbohydrate binding domain DUF525 PF04379.9 ESS69883.1 - 1.9e-30 104.6 0.1 4.4e-30 103.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF525) RCC1 PF00415.13 ESS69884.1 - 1.3e-74 246.1 39.7 3e-15 56.1 0.3 13.3 12 2 0 12 12 12 11 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS69884.1 - 9.5e-47 155.7 66.4 3.4e-07 29.6 0.2 14.1 14 0 0 14 14 14 11 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.6 ESS69884.1 - 0.18 11.0 0.1 29 3.7 0.0 3.4 4 0 0 4 4 4 0 TUP1-like enhancer of split zf-RING_UBOX PF13445.1 ESS69885.1 - 0.0055 16.4 0.0 0.026 14.2 0.0 2.2 1 0 0 1 1 1 1 RING-type zinc-finger DUF3043 PF11241.3 ESS69885.1 - 0.051 13.1 1.1 0.12 12.0 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) SDA1 PF05285.7 ESS69885.1 - 0.21 10.8 23.4 0.014 14.6 12.4 1.7 2 0 0 2 2 2 0 SDA1 Pex14_N PF04695.8 ESS69885.1 - 9.3 6.2 31.3 0.016 15.2 1.7 4.4 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DAGK_cat PF00781.19 ESS69887.1 - 3.9e-13 48.9 0.0 6.8e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Oxysterol_BP PF01237.13 ESS69890.1 - 1.8e-51 174.6 0.0 1.5e-50 171.6 0.0 1.9 1 1 0 1 1 1 1 Oxysterol-binding protein DUF4073 PF13285.1 ESS69890.1 - 0.09 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) DUF2012 PF09430.5 ESS69891.1 - 9.6e-30 102.9 0.1 1.2e-29 102.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.1 ESS69891.1 - 0.0006 19.8 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain ABC2_membrane_3 PF12698.2 ESS69891.1 - 0.0092 15.0 0.0 0.01 14.8 0.0 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein KRAB PF01352.22 ESS69893.1 - 0.037 13.4 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 KRAB box Acyl-ACP_TE PF01643.12 ESS69895.1 - 1.6e-05 23.9 0.2 6.4e-05 22.0 0.1 2.1 1 1 0 1 1 1 1 Acyl-ACP thioesterase PPR_2 PF13041.1 ESS69897.1 - 8.4e-12 44.8 4.4 2.3e-07 30.6 0.3 3.6 1 1 2 3 3 3 3 PPR repeat family PPR PF01535.15 ESS69897.1 - 1e-05 25.1 10.3 0.0013 18.5 0.1 4.4 4 0 0 4 4 4 1 PPR repeat PPR_3 PF13812.1 ESS69897.1 - 0.00021 21.3 4.3 0.027 14.7 0.1 4.5 4 0 0 4 4 4 1 Pentatricopeptide repeat domain Cas_Csd1 PF09709.5 ESS69897.1 - 0.086 11.1 0.2 0.19 10.0 0.1 1.6 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Csd1) Taxilin PF09728.4 ESS69898.1 - 8e-07 28.4 29.2 8e-07 28.4 20.2 2.1 1 1 1 2 2 2 2 Myosin-like coiled-coil protein Tropomyosin_1 PF12718.2 ESS69898.1 - 0.00025 20.9 51.8 0.047 13.5 10.0 3.2 1 1 2 3 3 3 3 Tropomyosin like HsbA PF12296.3 ESS69898.1 - 0.00059 19.6 0.5 0.002 17.9 0.2 2.0 1 1 0 1 1 1 1 Hydrophobic surface binding protein A Cluap1 PF10234.4 ESS69898.1 - 0.0044 16.2 20.5 0.0044 16.2 14.2 2.5 1 1 1 2 2 2 1 Clusterin-associated protein-1 FlxA PF14282.1 ESS69898.1 - 0.017 15.0 2.0 0.017 15.0 1.4 4.4 2 1 2 5 5 5 0 FlxA-like protein RRM_5 PF13893.1 ESS69900.1 - 1.3e-08 34.5 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69900.1 - 4.8e-06 26.4 0.0 7.9e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS69900.1 - 0.00036 20.0 0.0 0.00078 19.0 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) K1 PF02960.9 ESS69901.1 - 0.033 14.2 0.1 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 K1 glycoprotein DJ-1_PfpI_N PF13587.1 ESS69901.1 - 0.047 13.2 0.2 0.12 11.9 0.1 1.7 1 0 0 1 1 1 0 N-terminal domain of DJ-1_PfpI family Ank_2 PF12796.2 ESS69903.1 - 4.1e-06 27.0 0.0 1.1e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESS69903.1 - 4.3e-06 26.7 0.2 2.1e-05 24.6 0.1 2.2 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS69903.1 - 0.0014 19.1 0.1 0.0069 16.8 0.1 2.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS69903.1 - 0.043 14.0 0.2 1.3 9.4 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.25 ESS69903.1 - 0.058 13.2 0.0 0.23 11.3 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeat LRR_6 PF13516.1 ESS69904.1 - 2.4e-25 85.7 33.5 0.16 12.1 0.0 12.9 14 0 0 14 14 14 9 Leucine Rich repeat LRR_4 PF12799.2 ESS69904.1 - 1e-09 37.7 20.3 0.032 13.8 0.1 7.2 4 1 4 8 8 8 5 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESS69904.1 - 1.6e-06 27.3 19.0 6.8 7.3 0.0 9.9 11 0 0 11 11 11 1 Leucine rich repeat LRR_1 PF00560.28 ESS69904.1 - 5e-06 25.8 23.8 4.9 7.5 0.1 10.2 10 3 1 11 11 11 4 Leucine Rich Repeat LRR_8 PF13855.1 ESS69904.1 - 0.047 13.4 25.4 0.062 13.0 0.7 7.1 1 1 9 10 10 10 0 Leucine rich repeat PAP_assoc PF03828.14 ESS69905.1 - 4.4e-05 23.3 0.0 0.00015 21.6 0.0 1.9 2 0 0 2 2 2 1 Cid1 family poly A polymerase ATP_bind_1 PF03029.12 ESS69906.1 - 1.2e-49 169.0 0.0 1.8e-48 165.1 0.0 2.0 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 ESS69906.1 - 0.0044 17.8 0.1 0.017 15.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESS69906.1 - 0.0056 16.5 0.0 0.018 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESS69906.1 - 0.062 13.4 0.0 0.13 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ESS69906.1 - 0.14 12.3 0.4 0.35 11.0 0.3 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ESS69906.1 - 0.66 10.2 3.3 0.33 11.2 0.2 2.0 2 0 0 2 2 2 0 AAA domain DUF2474 PF10617.4 ESS69907.1 - 0.0041 16.6 0.1 0.012 15.2 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2474) IBN_N PF03810.14 ESS69907.1 - 0.073 12.9 0.1 0.22 11.4 0.1 1.9 1 0 0 1 1 1 0 Importin-beta N-terminal domain DUF4580 PF15162.1 ESS69908.1 - 0.027 13.8 0.1 0.23 10.7 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4580) Cas_Csa5 PF09702.5 ESS69908.1 - 0.031 14.3 1.9 0.13 12.3 0.0 2.8 3 2 0 3 3 3 0 CRISPR-associated protein (Cas_Csa5) PAF-AH_p_II PF03403.8 ESS69908.1 - 0.068 11.4 5.2 0.11 10.7 3.6 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II HTH_32 PF13565.1 ESS69908.1 - 0.15 12.8 1.1 0.89 10.3 0.0 2.6 2 1 1 3 3 3 0 Homeodomain-like domain DUF3763 PF12592.3 ESS69908.1 - 0.35 10.5 0.1 0.35 10.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3763) Peptidase_S46 PF10459.4 ESS69908.1 - 0.52 8.6 8.9 0.66 8.3 6.2 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF4164 PF13747.1 ESS69908.1 - 9.4 6.4 15.3 0.94 9.6 5.7 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF1358 PF07096.6 ESS69910.1 - 0.00014 21.5 0.9 0.00026 20.6 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) ParA PF10609.4 ESS69911.1 - 3.2e-37 126.2 0.2 7.1e-37 125.1 0.1 1.6 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 ESS69911.1 - 3.5e-17 62.4 0.0 5.8e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.10 ESS69911.1 - 4.5e-07 29.2 0.7 4.2e-05 22.7 0.1 3.1 3 1 0 3 3 3 1 Anion-transporting ATPase MipZ PF09140.6 ESS69911.1 - 2.6e-06 26.7 0.1 0.00024 20.2 0.1 2.1 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.1 ESS69911.1 - 7.3e-05 22.7 0.1 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESS69911.1 - 0.0002 20.7 0.3 0.00054 19.4 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS69911.1 - 0.0025 17.5 0.3 0.4 10.4 0.3 2.5 2 0 0 2 2 2 1 Part of AAA domain Fer4_NifH PF00142.13 ESS69911.1 - 0.0082 15.3 0.0 0.028 13.6 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArgK PF03308.11 ESS69911.1 - 0.044 12.5 0.1 0.067 11.9 0.1 1.2 1 0 0 1 1 1 0 ArgK protein APS_kinase PF01583.15 ESS69911.1 - 0.057 13.0 0.1 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_17 PF13207.1 ESS69911.1 - 0.059 14.1 0.3 0.11 13.3 0.2 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 ESS69911.1 - 0.069 12.8 0.7 0.13 11.9 0.5 1.4 1 0 0 1 1 1 0 NACHT domain AAA_26 PF13500.1 ESS69911.1 - 0.071 12.7 0.1 3.9 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zn_Tnp_IS1595 PF12760.2 ESS69911.1 - 0.083 12.7 0.3 0.19 11.5 0.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF258 PF03193.11 ESS69911.1 - 0.14 11.2 0.2 0.31 10.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 PseudoU_synth_1 PF01416.15 ESS69912.1 - 0.0074 16.7 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridine synthase Cwf_Cwc_15 PF04889.7 ESS69912.1 - 0.25 11.0 4.7 0.4 10.3 3.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein 2OG-FeII_Oxy_2 PF13532.1 ESS69913.1 - 2.6e-10 40.4 0.0 4.2e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESS69913.1 - 6.7e-08 32.7 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PAP_assoc PF03828.14 ESS69914.1 - 2.1e-16 59.6 0.5 4.8e-16 58.4 0.3 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESS69914.1 - 7.1e-05 23.0 0.0 0.00025 21.3 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain TPR_11 PF13414.1 ESS69915.1 - 1.4e-54 181.6 20.3 4.3e-09 35.8 0.2 8.7 4 3 6 10 10 10 9 TPR repeat TPR_2 PF07719.12 ESS69915.1 - 4.5e-42 138.6 24.4 8.3e-05 22.2 0.1 13.7 14 0 0 14 14 14 9 Tetratricopeptide repeat TPR_1 PF00515.23 ESS69915.1 - 2.7e-36 121.7 15.2 0.0002 20.8 0.1 12.7 13 1 0 13 13 13 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESS69915.1 - 1.1e-21 76.8 29.4 0.00061 20.3 0.1 8.1 6 2 2 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.1 ESS69915.1 - 4.3e-21 73.0 6.2 0.013 15.2 0.0 11.4 12 1 1 13 13 12 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS69915.1 - 1.8e-20 71.5 13.3 0.023 15.3 0.0 10.4 5 4 6 11 11 10 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESS69915.1 - 3.3e-19 67.4 12.4 0.0097 16.0 0.0 11.9 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESS69915.1 - 5.4e-19 67.9 29.1 4.3e-05 23.3 0.1 8.2 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESS69915.1 - 2.4e-18 65.7 20.8 0.0019 18.0 0.4 7.6 5 3 2 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESS69915.1 - 8.5e-12 45.2 10.7 0.3 11.4 0.0 7.7 6 1 1 7 7 7 3 Tetratricopeptide repeat Apc3 PF12895.2 ESS69915.1 - 6.4e-10 39.0 21.5 0.0074 16.4 0.1 6.2 1 1 5 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESS69915.1 - 9.9e-09 35.0 18.2 0.18 12.3 0.0 10.4 12 0 0 12 12 11 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS69915.1 - 1.5e-08 33.7 4.3 0.54 10.1 0.0 8.2 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESS69915.1 - 1.5e-05 24.7 8.4 1.8 8.5 0.0 7.2 6 1 1 7 7 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS69915.1 - 0.00063 19.5 4.9 13 5.7 0.0 5.2 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat HemY_N PF07219.8 ESS69915.1 - 0.002 17.6 0.1 0.17 11.4 0.0 2.6 2 0 0 2 2 2 1 HemY protein N-terminus SHNi-TPR PF10516.4 ESS69915.1 - 0.038 13.2 13.5 0.58 9.4 0.0 5.4 6 0 0 6 6 6 0 SHNi-TPR Vps52 PF04129.7 ESS69917.1 - 1.1e-55 189.1 0.7 8.2e-19 67.5 0.0 3.1 3 0 0 3 3 3 3 Vps52 / Sac2 family Sec3_C PF09763.4 ESS69917.1 - 0.12 10.5 1.3 9.8 4.1 0.0 3.1 3 0 0 3 3 3 0 Exocyst complex component Sec3 IU_nuc_hydro PF01156.14 ESS69918.1 - 2.3e-17 63.2 0.0 3.6e-17 62.5 0.0 1.3 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Cyclin_N PF00134.18 ESS69919.1 - 1.7e-24 85.7 1.3 1.7e-24 85.7 0.1 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESS69919.1 - 0.077 12.9 0.9 0.19 11.6 0.1 2.0 2 1 0 2 2 2 0 Cyclin, C-terminal domain DUF2830 PF11125.3 ESS69919.1 - 0.18 11.5 1.4 0.35 10.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2830) THF_DHG_CYH_C PF02882.14 ESS69920.1 - 7.4e-63 210.4 0.8 1.3e-62 209.6 0.6 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 ESS69920.1 - 2.3e-38 130.8 0.2 3.1e-38 130.4 0.1 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 6PF2K PF01591.13 ESS69921.1 - 4.4e-33 114.2 0.0 7e-33 113.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Ank_2 PF12796.2 ESS69921.1 - 1.7e-18 66.7 0.2 5.6e-17 61.8 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) His_Phos_1 PF00300.17 ESS69921.1 - 4.7e-16 59.2 0.0 1.2e-15 57.8 0.0 1.8 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ank_4 PF13637.1 ESS69921.1 - 7.5e-16 58.1 0.2 7.9e-09 35.7 0.0 3.7 3 1 1 4 4 3 2 Ankyrin repeats (many copies) Ank PF00023.25 ESS69921.1 - 5.8e-15 54.2 0.1 3.1e-09 36.1 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESS69921.1 - 1.1e-13 50.9 0.1 2.6e-09 37.0 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS69921.1 - 1.5e-08 34.0 0.0 6e-05 22.9 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat AAA_33 PF13671.1 ESS69921.1 - 1.1e-05 25.3 0.0 2.3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESS69921.1 - 0.00047 19.4 0.0 0.00081 18.6 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DinB_2 PF12867.2 ESS69921.1 - 0.0055 17.0 1.2 0.012 16.0 0.3 1.9 2 0 0 2 2 2 1 DinB superfamily AAA_17 PF13207.1 ESS69921.1 - 0.0068 17.2 0.0 0.016 15.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESS69921.1 - 0.01 16.0 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESS69921.1 - 0.063 13.0 0.0 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS69921.1 - 0.1 12.7 0.0 0.3 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESS69921.1 - 0.11 11.5 0.1 0.35 9.9 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin DUF1192 PF06698.6 ESS69921.1 - 5.7 6.8 6.7 2.8 7.7 0.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) MMR_HSR1 PF01926.18 ESS69922.1 - 2.6e-39 133.7 0.0 2.2e-18 66.2 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESS69922.1 - 7.9e-21 74.3 0.2 8.2e-11 41.6 0.0 3.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESS69922.1 - 3.8e-17 62.6 0.1 0.00015 21.6 0.0 4.3 3 1 1 4 4 4 3 Dynamin family KH_dom-like PF14714.1 ESS69922.1 - 6.3e-17 61.3 0.4 1.3e-16 60.3 0.3 1.6 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.13 ESS69922.1 - 1.2e-15 57.1 0.0 1.6e-08 33.9 0.0 2.6 2 1 0 2 2 2 2 Ferrous iron transport protein B Miro PF08477.8 ESS69922.1 - 2e-14 54.0 0.0 5.4e-06 26.8 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein AIG1 PF04548.11 ESS69922.1 - 1e-11 44.3 0.0 2.5e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 AIG1 family SRPRB PF09439.5 ESS69922.1 - 3.1e-09 36.3 0.0 2.9e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit DUF258 PF03193.11 ESS69922.1 - 1.2e-06 27.8 0.0 0.049 12.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Ras PF00071.17 ESS69922.1 - 2.6e-06 26.9 0.0 0.0025 17.2 0.0 2.7 2 1 0 2 2 2 2 Ras family ABC_tran PF00005.22 ESS69922.1 - 1.7e-05 25.1 0.0 0.24 11.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Gtr1_RagA PF04670.7 ESS69922.1 - 2.2e-05 23.7 0.0 0.0086 15.2 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 ESS69922.1 - 2.3e-05 23.9 0.0 0.11 11.9 0.0 3.3 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.1 ESS69922.1 - 3.2e-05 24.2 0.0 0.31 11.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 ESS69922.1 - 4.8e-05 23.0 0.0 0.085 12.5 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B GBP PF02263.14 ESS69922.1 - 0.00065 18.8 0.0 0.69 8.9 0.0 2.2 2 0 0 2 2 2 2 Guanylate-binding protein, N-terminal domain AAA_17 PF13207.1 ESS69922.1 - 0.00092 20.0 0.1 2 9.2 0.0 3.4 3 1 0 3 3 2 1 AAA domain cobW PF02492.14 ESS69922.1 - 0.0022 17.4 0.5 0.27 10.6 0.0 3.4 3 1 1 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 ESS69922.1 - 0.0037 16.7 0.0 2.2 7.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain IIGP PF05049.8 ESS69922.1 - 0.0039 16.0 0.0 0.37 9.5 0.0 2.4 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) Septin PF00735.13 ESS69922.1 - 0.0041 16.1 0.0 0.4 9.6 0.0 2.3 2 0 0 2 2 2 1 Septin Arch_ATPase PF01637.13 ESS69922.1 - 0.027 14.1 0.0 4.5 6.9 0.0 2.4 2 0 0 2 2 2 0 Archaeal ATPase AAA_10 PF12846.2 ESS69922.1 - 0.045 13.1 0.0 8.9 5.6 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain PAP2_C PF14360.1 ESS69923.1 - 0.027 14.7 0.0 2.9 8.2 0.0 2.4 2 0 0 2 2 2 0 PAP2 superfamily C-terminal DUF3147 PF11345.3 ESS69925.1 - 1.9 8.5 6.0 0.25 11.3 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3147) DUF2305 PF10230.4 ESS69927.1 - 2.4e-47 161.6 0.0 3e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 ESS69927.1 - 1.3e-09 38.2 0.1 1.6e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS69927.1 - 7e-07 29.0 0.0 8.5e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 ESS69927.1 - 0.085 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein SIR2 PF02146.12 ESS69928.1 - 7.8e-58 195.1 0.0 1e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 Sir2 family POM121 PF15229.1 ESS69928.1 - 0.071 12.5 0.5 0.1 12.0 0.4 1.2 1 0 0 1 1 1 0 POM121 family PI3_PI4_kinase PF00454.22 ESS69929.1 - 0.029 13.8 0.1 0.063 12.7 0.1 1.7 1 1 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase eRF1_1 PF03463.10 ESS69930.1 - 1.5e-35 121.6 0.2 2.6e-35 120.8 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.10 ESS69930.1 - 5.2e-16 59.1 0.0 7.6e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 ESS69930.1 - 1.6e-14 54.1 0.0 4.9e-14 52.5 0.0 1.9 1 0 0 1 1 1 1 eRF1 domain 3 Ribosomal_L30 PF00327.15 ESS69931.1 - 2.1e-18 65.6 1.0 3.9e-18 64.7 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 ESS69931.1 - 1.3e-16 60.4 12.0 2.2e-16 59.6 8.4 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain FliD_C PF07195.7 ESS69932.1 - 0.0062 15.8 0.6 0.0062 15.8 0.4 1.9 2 0 0 2 2 2 1 Flagellar hook-associated protein 2 C-terminus Racemase_4 PF13615.1 ESS69933.1 - 9.8e-21 73.9 0.4 2.9e-20 72.3 0.1 2.0 2 0 0 2 2 2 1 Putative alanine racemase MCM_bind PF09739.4 ESS69933.1 - 7.8e-15 54.5 0.0 1.9e-14 53.2 0.0 1.6 1 1 0 1 1 1 1 Mini-chromosome maintenance replisome factor Pribosyltran PF00156.22 ESS69934.1 - 8.5e-15 54.5 0.0 1.1e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESS69934.1 - 0.00034 19.9 0.0 0.00045 19.4 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 ESS69934.1 - 0.032 13.5 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase Pribosyltran PF00156.22 ESS69935.1 - 2.9e-18 65.7 0.0 3.8e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESS69935.1 - 0.0022 17.2 0.0 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Actin PF00022.14 ESS69937.1 - 1.7e-08 33.3 0.5 0.029 12.8 0.1 3.0 2 1 0 3 3 3 3 Actin DUF562 PF04763.7 ESS69939.1 - 0.069 12.3 0.1 0.086 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF562) Rhomboid PF01694.17 ESS69940.1 - 0.59 10.1 6.7 1.1 9.3 2.7 2.5 2 1 0 2 2 2 0 Rhomboid family OGFr_N PF04664.8 ESS69942.1 - 2.5e-08 33.5 0.4 6.7e-05 22.3 0.0 2.6 3 0 0 3 3 3 2 Opioid growth factor receptor (OGFr) conserved region GSHPx PF00255.14 ESS69943.1 - 1.7e-38 130.2 0.1 2.2e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 ESS69943.1 - 3.8e-05 23.3 0.0 4.9e-05 22.9 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESS69943.1 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.6 1 1 0 1 1 1 1 Redoxin Feld-I_B PF09252.5 ESS69944.1 - 0.016 15.1 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 0 Allergen Fel d I-B chain MAPKK1_Int PF08923.5 ESS69944.1 - 0.048 13.2 0.0 6.7 6.3 0.0 2.0 2 0 0 2 2 2 0 Mitogen-activated protein kinase kinase 1 interacting GSHPx PF00255.14 ESS69945.1 - 2.2e-37 126.7 0.1 2.8e-37 126.3 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 ESS69945.1 - 0.00043 19.9 0.0 0.00059 19.5 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESS69945.1 - 0.0038 16.7 0.0 0.0064 16.0 0.0 1.5 1 1 0 1 1 1 1 Redoxin Mab-21 PF03281.9 ESS69946.1 - 0.098 11.7 0.1 0.24 10.4 0.0 1.6 2 0 0 2 2 2 0 Mab-21 protein SNARE PF05739.14 ESS69947.1 - 7e-07 28.8 0.7 7e-07 28.8 0.5 1.9 2 0 0 2 2 2 1 SNARE domain Syntaxin-6_N PF09177.6 ESS69947.1 - 0.00012 22.3 0.3 0.00012 22.3 0.2 2.3 2 1 1 3 3 3 1 Syntaxin 6, N-terminal Rifin_STEVOR PF02009.11 ESS69947.1 - 0.002 17.8 1.9 0.0033 17.1 1.3 1.4 1 1 0 1 1 1 1 Rifin/stevor family Methyltransf_PK PF05891.7 ESS69947.1 - 0.0044 16.3 0.3 0.074 12.3 0.2 2.3 2 1 0 2 2 2 1 AdoMet dependent proline di-methyltransferase DUF972 PF06156.8 ESS69947.1 - 0.84 10.0 4.0 1.5 9.2 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ODV-E18 PF10717.4 ESS69947.1 - 5.7 6.4 5.5 10 5.6 1.8 2.3 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 IF4E PF01652.13 ESS69948.1 - 1.6e-05 24.5 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Ribosomal_S9 PF00380.14 ESS69949.1 - 2.5e-29 102.0 2.5 2.9e-29 101.7 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CobN-Mg_chel PF02514.11 ESS69949.1 - 0.057 10.8 0.0 0.06 10.7 0.0 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase Ribosomal_S9 PF00380.14 ESS69950.1 - 2.5e-29 102.0 2.5 2.9e-29 101.7 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CobN-Mg_chel PF02514.11 ESS69950.1 - 0.057 10.8 0.0 0.06 10.7 0.0 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase DUF2457 PF10446.4 ESS69951.1 - 1.2 7.8 5.4 1.2 7.7 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRM_1 PF00076.17 ESS69952.1 - 1.3e-11 43.9 0.1 2e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS69952.1 - 5.9e-10 38.9 0.1 9.5e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS69952.1 - 6.2e-06 25.9 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3268 PF11672.3 ESS69954.1 - 0.001 19.0 0.1 0.001 19.0 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3268) zf-MYND PF01753.13 ESS69954.1 - 0.03 14.1 6.5 3.1 7.7 2.3 3.1 2 1 0 2 2 2 0 MYND finger zf-H2C2_2 PF13465.1 ESS69954.1 - 0.73 10.2 0.1 0.73 10.2 0.1 3.1 2 1 0 2 2 2 0 Zinc-finger double domain DZR PF12773.2 ESS69954.1 - 1.1 9.1 10.5 6 6.7 0.7 3.1 2 1 1 3 3 3 0 Double zinc ribbon IBR PF01485.16 ESS69954.1 - 3.7 7.4 12.6 91 3.0 8.7 2.1 1 1 0 1 1 1 0 IBR domain ATP-synt_C PF00137.16 ESS69955.1 - 2.2e-17 62.6 12.0 3.1e-17 62.2 8.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit C Thioredoxin PF00085.15 ESS69956.1 - 1.4e-58 194.9 0.1 3.4e-28 97.3 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 ESS69956.1 - 5.7e-22 78.0 0.8 2.1e-10 40.7 0.1 3.5 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESS69956.1 - 5.7e-16 58.3 0.1 1.9e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like ERp29 PF07749.7 ESS69956.1 - 5e-14 52.6 2.3 5e-14 52.6 1.6 1.9 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_8 PF13905.1 ESS69956.1 - 3.8e-11 42.9 0.8 0.012 15.6 0.0 4.6 3 2 1 4 4 4 2 Thioredoxin-like Redoxin PF08534.5 ESS69956.1 - 1.8e-10 40.5 0.2 0.00022 20.7 0.0 2.4 2 0 0 2 2 2 2 Redoxin AhpC-TSA PF00578.16 ESS69956.1 - 1.3e-09 37.8 0.4 0.00039 20.1 0.0 2.9 1 1 2 3 3 3 2 AhpC/TSA family ERp29_N PF07912.8 ESS69956.1 - 6.7e-09 35.7 0.3 0.00026 20.9 0.0 2.3 2 0 0 2 2 2 2 ERp29, N-terminal domain Thioredoxin_9 PF14595.1 ESS69956.1 - 1.8e-05 24.3 0.0 0.076 12.5 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin HyaE PF07449.6 ESS69956.1 - 0.00012 21.9 0.0 0.39 10.6 0.0 2.5 2 0 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Thioredoxin_6 PF13848.1 ESS69956.1 - 0.00018 21.3 0.7 0.0035 17.1 0.2 2.6 1 1 2 3 3 3 3 Thioredoxin-like domain Glutaredoxin PF00462.19 ESS69956.1 - 0.0052 16.7 0.5 6.2 6.8 0.0 3.3 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin_4 PF13462.1 ESS69956.1 - 0.012 15.6 1.6 0.62 10.0 0.1 3.0 2 2 1 3 3 3 0 Thioredoxin IZUMO PF15005.1 ESS69956.1 - 0.32 11.0 1.9 0.59 10.1 0.2 2.3 3 0 0 3 3 3 0 Izumo sperm-egg fusion RdRP_2 PF00978.16 ESS69997.1 - 0.06 12.0 0.0 8.4 4.9 0.0 2.1 2 0 0 2 2 2 0 RNA dependent RNA polymerase Ribosomal_L19e PF01280.15 ESS69997.1 - 0.12 12.1 3.8 0.27 10.9 2.6 1.5 1 0 0 1 1 1 0 Ribosomal protein L19e PPR_2 PF13041.1 ESS69998.1 - 0.00094 19.1 0.1 0.0047 16.8 0.0 2.1 2 0 0 2 2 2 1 PPR repeat family Ax_dynein_light PF10211.4 ESS70000.1 - 6.8e-60 202.1 12.0 8.7e-60 201.8 8.4 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain APG6 PF04111.7 ESS70000.1 - 0.68 8.9 7.8 1 8.3 5.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1117 PF06547.7 ESS70001.1 - 0.16 12.0 12.4 0.2 11.7 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) Nucleoplasmin PF03066.10 ESS70002.1 - 0.25 10.8 3.1 0.52 9.8 2.1 1.4 1 0 0 1 1 1 0 Nucleoplasmin PUF PF00806.14 ESS70003.1 - 1.7e-51 168.8 5.2 2e-06 26.9 0.1 9.3 9 0 0 9 9 9 9 Pumilio-family RNA binding repeat BNR_3 PF13859.1 ESS70004.1 - 7.6e-41 140.1 0.1 2.4e-40 138.5 0.0 1.9 2 0 0 2 2 2 1 BNR repeat-like domain Laminin_G_3 PF13385.1 ESS70004.1 - 4.6e-14 52.9 3.3 1.1e-13 51.7 2.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tr-sialidase_C PF11052.3 ESS70004.1 - 4.5e-10 39.2 5.0 8.4e-10 38.3 3.5 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal Ldh_1_N PF00056.18 ESS70004.1 - 0.063 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DUF108 PF01958.13 ESS70005.1 - 0.22 11.7 1.5 0.22 11.7 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF108 NARP1 PF12569.3 ESS70006.1 - 2.9e-88 296.8 14.1 1.1e-85 288.3 5.1 2.7 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_11 PF13414.1 ESS70006.1 - 4.4e-19 67.8 14.3 3.6e-06 26.5 0.0 5.7 5 1 0 5 5 5 3 TPR repeat TPR_2 PF07719.12 ESS70006.1 - 5.2e-15 54.0 16.6 1e-06 28.1 0.0 8.5 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70006.1 - 1.6e-09 38.1 25.6 0.0037 17.9 0.0 8.3 7 2 1 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS70006.1 - 1.5e-08 34.8 15.0 0.00054 20.2 0.0 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESS70006.1 - 1.5e-08 33.8 16.1 4.2e-07 29.2 0.0 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70006.1 - 5.7e-08 32.7 19.0 0.016 15.7 0.0 8.7 7 2 3 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70006.1 - 1.6e-07 31.1 17.0 0.0044 16.9 0.0 6.1 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70006.1 - 1.9e-06 27.2 3.1 0.0091 15.7 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70006.1 - 6.4e-05 22.4 7.6 0.083 12.7 0.0 6.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS70006.1 - 7.2e-05 22.6 3.0 0.21 11.8 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70006.1 - 0.00014 21.6 7.8 0.0029 17.4 0.2 4.5 3 1 2 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS70006.1 - 0.00035 20.3 0.0 5.5 6.9 0.0 3.8 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 ESS70006.1 - 0.01 16.2 12.6 0.25 11.8 0.0 5.8 5 0 0 5 5 4 0 Tetratricopeptide repeat PA28_alpha PF02251.13 ESS70006.1 - 0.023 14.8 0.2 0.22 11.6 0.1 2.7 2 0 0 2 2 2 0 Proteasome activator pa28 alpha subunit Ketoacyl-synt_C PF02801.17 ESS70006.1 - 0.058 13.2 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain DnaJ PF00226.26 ESS70007.1 - 1.5e-09 37.4 2.7 1.7e-09 37.2 0.9 1.8 1 1 1 2 2 2 1 DnaJ domain FUSC_2 PF13515.1 ESS70007.1 - 0.022 14.6 0.2 0.038 13.9 0.1 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein-like DUF342 PF03961.8 ESS70009.1 - 0.15 10.4 2.0 0.19 10.1 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.7 ESS70009.1 - 3.2 6.7 11.3 2.4 7.0 6.7 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 Glycolytic PF00274.14 ESS70011.1 - 1.2e-146 487.6 0.0 1.3e-146 487.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I eIF-3_zeta PF05091.7 ESS70011.1 - 0.089 11.4 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PP2C PF00481.16 ESS70013.1 - 8.4e-16 58.1 0.0 1.7e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C PqqD PF05402.7 ESS70013.1 - 0.082 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Glyco_transf_22 PF03901.12 ESS70016.1 - 6.1e-99 331.8 28.0 7.5e-99 331.5 19.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family COQ7 PF03232.8 ESS70017.1 - 0.0047 16.4 0.1 0.0063 16.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Abhydrolase_9 PF10081.4 ESS70017.1 - 0.041 12.5 0.1 0.05 12.2 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family CorA PF01544.13 ESS70020.1 - 0.00024 20.2 0.2 0.00024 20.2 0.1 2.5 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein Flu_NS2 PF00601.14 ESS70020.1 - 0.025 14.7 0.1 0.07 13.3 0.0 1.7 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) eIF3_N PF09440.5 ESS70020.1 - 0.072 13.2 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain Memo PF01875.12 ESS70021.1 - 2.2e-70 236.6 0.1 2.5e-70 236.4 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Adenine_deam_C PF13382.1 ESS70021.1 - 0.14 11.2 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain Exo_endo_phos PF03372.18 ESS70022.1 - 5.8e-10 39.5 0.7 9.1e-08 32.3 0.1 2.2 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family DUF89 PF01937.14 ESS70022.1 - 0.04 12.7 0.0 0.45 9.2 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function DUF89 HORMA PF02301.13 ESS70024.1 - 4.8e-53 179.7 0.0 7.8e-53 179.0 0.0 1.3 1 0 0 1 1 1 1 HORMA domain WHIM3 PF15614.1 ESS70026.1 - 0.007 16.1 0.0 0.0094 15.7 0.0 1.6 1 1 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 3 WHIM1 PF15612.1 ESS70026.1 - 0.0097 15.8 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 WHIM2 PF15613.1 ESS70026.1 - 0.012 15.5 0.0 0.033 14.1 0.0 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 HD_3 PF13023.1 ESS70026.1 - 0.059 13.1 0.1 0.44 10.2 0.3 1.9 2 0 0 2 2 2 0 HD domain Phage_1_1 PF08200.6 ESS70026.1 - 0.061 13.5 1.7 19 5.5 0.6 2.8 2 0 0 2 2 2 0 Bacteriophage 1.1 Protein RHD3 PF05879.7 ESS70026.1 - 0.075 10.9 0.2 0.1 10.5 0.1 1.1 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) Mitofilin PF09731.4 ESS70026.1 - 1 7.9 6.0 1.4 7.4 4.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DDT PF02791.12 ESS70027.1 - 0.00049 19.8 0.2 0.001 18.7 0.2 1.5 1 0 0 1 1 1 1 DDT domain DUF4629 PF15442.1 ESS70027.1 - 0.015 15.4 0.7 0.015 15.4 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4629) CLAMP PF14769.1 ESS70029.1 - 1.4e-33 115.0 0.2 2.2e-33 114.3 0.1 1.3 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 HSBP1 PF06825.7 ESS70029.1 - 0.0023 17.4 0.6 0.008 15.7 0.1 2.0 2 0 0 2 2 2 1 Heat shock factor binding protein 1 DUF4633 PF15464.1 ESS70030.1 - 0.093 12.5 1.2 0.23 11.2 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) DUF2390 PF09523.5 ESS70031.1 - 0.95 9.6 7.3 6.3 7.0 0.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2390) WD40 PF00400.27 ESS70034.1 - 1.9e-20 71.8 16.2 2.4e-11 43.0 0.3 7.2 8 0 0 8 8 8 5 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESS70034.1 - 0.00029 19.7 4.1 0.076 11.7 0.0 5.3 5 1 2 7 7 7 1 Coatomer WD associated region Nic96 PF04097.9 ESS70034.1 - 0.00038 18.7 0.1 0.26 9.3 0.1 2.2 2 0 0 2 2 2 2 Nup93/Nic96 Clathrin PF00637.15 ESS70034.1 - 0.0011 18.5 0.2 0.21 11.1 0.0 3.3 2 1 1 3 3 3 1 Region in Clathrin and VPS BBS2_Mid PF14783.1 ESS70034.1 - 0.02 14.6 0.0 3.5 7.4 0.0 3.6 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Mad3_BUB1_I PF08311.7 ESS70034.1 - 0.034 13.9 1.3 4 7.2 0.1 2.6 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 Hint PF01079.15 ESS70034.1 - 0.049 12.8 0.0 0.12 11.5 0.0 1.6 1 0 0 1 1 1 0 Hint module TPR_2 PF07719.12 ESS70034.1 - 0.49 10.4 15.9 0.83 9.7 0.1 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70034.1 - 0.6 10.0 7.9 22 5.1 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Rad50_zn_hook PF04423.9 ESS70034.1 - 0.74 9.3 6.7 6.5 6.3 0.0 3.4 3 0 0 3 3 3 0 Rad50 zinc hook motif TPR_1 PF00515.23 ESS70034.1 - 1.7 8.3 7.4 3 7.5 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2847 PF11009.3 ESS70035.1 - 0.04 13.5 0.2 0.097 12.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2847) Spc24 PF08286.6 ESS70035.1 - 0.073 12.7 1.7 0.11 12.1 1.2 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Dynein_heavy PF03028.10 ESS70037.1 - 1.7e-227 756.9 2.6 1.9e-227 756.7 0.0 2.5 4 0 0 4 4 3 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 ESS70037.1 - 1e-127 426.0 17.6 1e-127 426.0 12.2 3.0 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESS70037.1 - 2.9e-92 308.3 0.0 8.7e-92 306.8 0.0 1.9 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESS70037.1 - 9.3e-65 218.2 0.6 1.8e-64 217.3 0.4 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESS70037.1 - 3.5e-58 196.1 0.4 7.9e-58 194.9 0.3 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 ESS70037.1 - 1.1e-42 146.0 6.9 2e-42 145.2 4.8 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 ESS70037.1 - 8e-40 136.6 0.0 1.6e-39 135.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 ESS70037.1 - 5.7e-16 58.5 0.0 0.0007 19.3 0.0 6.2 4 2 1 5 5 5 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS70037.1 - 5e-09 36.3 0.0 0.0037 17.4 0.0 5.7 4 0 0 4 4 4 1 AAA domain AAA PF00004.24 ESS70037.1 - 8e-07 29.3 0.0 0.42 10.8 0.0 5.0 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ESS70037.1 - 4.7e-06 26.3 0.1 0.0067 16.1 0.0 4.2 3 0 0 3 3 3 1 NACHT domain RNA_helicase PF00910.17 ESS70037.1 - 5.4e-06 26.5 0.0 0.11 12.6 0.0 4.2 4 0 0 4 4 4 2 RNA helicase AAA_17 PF13207.1 ESS70037.1 - 0.00023 21.9 0.0 1.3 9.8 0.0 5.4 5 0 0 5 5 4 1 AAA domain AAA_19 PF13245.1 ESS70037.1 - 0.0041 16.8 0.5 0.66 9.7 0.1 3.5 4 0 0 4 4 4 1 Part of AAA domain AAA_18 PF13238.1 ESS70037.1 - 0.016 15.4 0.0 8 6.7 0.0 4.4 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 ESS70037.1 - 0.017 14.6 0.0 0.95 8.9 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.1 ESS70037.1 - 0.019 14.8 0.2 2.5 7.9 0.0 3.9 4 0 0 4 4 3 0 AAA domain AAA_16 PF13191.1 ESS70037.1 - 0.022 14.7 12.1 0.69 9.8 0.0 5.7 5 1 1 6 6 6 0 AAA ATPase domain AAA_25 PF13481.1 ESS70037.1 - 0.06 12.7 4.5 0.78 9.1 0.0 3.0 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.16 ESS70037.1 - 0.12 11.5 1.8 41 3.2 0.0 4.4 5 0 0 5 5 5 0 Magnesium chelatase, subunit ChlI DUF853 PF05872.7 ESS70037.1 - 0.41 8.9 6.4 2.1 6.5 0.0 3.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF853) NUFIP2 PF15293.1 ESS70037.1 - 2.2 6.9 1.1 3.6 6.1 0.8 1.2 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 Ribonuclease_3 PF00636.21 ESS70038.1 - 0.0022 18.4 0.0 0.014 15.8 0.0 2.3 2 1 0 2 2 2 1 Ribonuclease III domain Requiem_N PF14051.1 ESS70038.1 - 0.01 15.7 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of DPF2/REQ. Pkinase PF00069.20 ESS70039.1 - 8.9e-73 244.6 0.0 1.2e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70039.1 - 5.4e-40 137.0 0.0 8.4e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70039.1 - 5.3e-05 22.3 0.0 0.00022 20.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESS70039.1 - 0.00014 20.9 0.1 0.00026 20.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SRP14 PF02290.10 ESS70039.1 - 0.066 13.1 0.9 19 5.2 0.0 3.1 3 0 0 3 3 3 0 Signal recognition particle 14kD protein Choline_kinase PF01633.15 ESS70039.1 - 0.17 11.4 0.0 0.52 9.8 0.0 1.8 1 0 0 1 1 1 0 Choline/ethanolamine kinase eIF-6 PF01912.13 ESS70040.1 - 2.2e-81 271.7 0.3 3.2e-81 271.1 0.2 1.2 1 0 0 1 1 1 1 eIF-6 family 2_5_RNA_ligase2 PF13563.1 ESS70040.1 - 0.12 12.0 0.0 0.35 10.5 0.0 1.8 2 0 0 2 2 2 0 2'-5' RNA ligase superfamily NifU PF01106.12 ESS70041.1 - 4.1e-19 68.1 0.1 7e-19 67.3 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.6 ESS70041.1 - 8.9e-08 31.6 0.0 2.1e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal HA2 PF04408.18 ESS70042.1 - 1.5e-18 66.7 0.0 5e-18 65.0 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESS70042.1 - 1.6e-18 66.5 0.0 5.6e-18 64.8 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESS70042.1 - 4.7e-13 48.8 0.0 1.3e-12 47.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS70042.1 - 5.2e-10 39.0 0.0 1.5e-09 37.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS70042.1 - 0.0016 18.5 1.4 0.027 14.5 1.0 2.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 ESS70042.1 - 0.0041 16.9 0.2 0.45 10.3 0.1 2.6 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit T2SE PF00437.15 ESS70042.1 - 0.005 15.7 2.1 0.012 14.4 1.4 1.7 1 1 0 1 1 1 1 Type II/IV secretion system protein KaiC PF06745.8 ESS70042.1 - 0.013 14.6 0.0 0.043 12.9 0.0 1.9 1 0 0 1 1 1 0 KaiC AAA_11 PF13086.1 ESS70042.1 - 0.014 14.9 1.5 0.12 11.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 ESS70042.1 - 0.021 14.2 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESS70042.1 - 0.026 13.9 0.0 1.4 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA-like domain NACHT PF05729.7 ESS70042.1 - 0.034 13.8 0.0 0.44 10.1 0.0 2.7 2 0 0 2 2 2 0 NACHT domain cobW PF02492.14 ESS70042.1 - 0.034 13.5 0.2 1.1 8.7 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 ESS70042.1 - 0.045 14.0 0.9 0.095 12.9 0.0 2.0 2 0 0 2 2 2 0 ABC transporter PhoH PF02562.11 ESS70042.1 - 0.046 12.9 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Miro PF08477.8 ESS70042.1 - 0.049 14.1 0.1 0.36 11.3 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein AAA_19 PF13245.1 ESS70042.1 - 0.063 13.0 0.0 0.2 11.4 0.0 1.9 1 1 0 1 1 1 0 Part of AAA domain AAA_29 PF13555.1 ESS70042.1 - 0.093 12.2 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pkinase PF00069.20 ESS70044.1 - 1.3e-55 188.3 0.0 1.6e-55 188.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70044.1 - 1.2e-33 116.2 0.0 1.6e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS70044.1 - 0.00023 20.9 0.2 0.014 15.1 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS70044.1 - 0.00027 20.0 0.0 0.0044 16.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 ESS70044.1 - 0.22 10.3 0.0 0.36 9.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 C2 PF00168.25 ESS70045.1 - 1.9e-24 85.3 0.0 1.6e-06 27.8 0.0 4.3 4 0 0 4 4 4 4 C2 domain PAM2 PF07145.10 ESS70046.1 - 0.0017 17.6 1.3 0.0044 16.4 0.9 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region zf-CCCH PF00642.19 ESS70046.1 - 0.0075 15.9 1.9 0.15 11.7 0.1 2.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) C2 PF00168.25 ESS70047.1 - 0.0014 18.4 0.0 0.0047 16.7 0.0 2.0 2 0 0 2 2 2 1 C2 domain cNMP_binding PF00027.24 ESS70048.1 - 2.3e-21 75.4 0.0 1.7e-12 47.0 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain C2 PF00168.25 ESS70048.1 - 0.012 15.4 0.0 0.33 10.8 0.0 2.6 3 0 0 3 3 3 0 C2 domain Tfb2 PF03849.9 ESS70050.1 - 8e-21 74.0 0.0 1.2e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 ESS70050.1 - 0.0074 16.0 0.0 0.027 14.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Rootletin PF15035.1 ESS70051.1 - 2.6 8.0 12.8 0.31 10.9 4.8 2.3 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Cation_efflux PF01545.16 ESS70052.1 - 4.8e-83 278.5 10.9 5.5e-83 278.3 7.6 1.0 1 0 0 1 1 1 1 Cation efflux family TPR_11 PF13414.1 ESS70056.1 - 2e-30 104.2 21.8 1.1e-15 56.9 0.7 5.9 4 2 2 6 6 6 4 TPR repeat TPR_1 PF00515.23 ESS70056.1 - 3.2e-23 80.3 3.7 0.00018 20.9 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70056.1 - 1.4e-18 65.2 18.3 1.9e-05 24.2 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat DnaJ PF00226.26 ESS70056.1 - 1.1e-13 50.6 0.0 5.6e-13 48.4 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain TPR_17 PF13431.1 ESS70056.1 - 1.1e-10 40.7 11.3 0.0024 17.9 0.2 6.6 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70056.1 - 6.8e-09 35.4 9.4 0.097 12.5 0.4 4.9 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESS70056.1 - 9.6e-08 32.2 12.2 0.0034 17.6 0.4 6.0 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70056.1 - 3.9e-06 26.2 0.1 0.34 10.8 0.0 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70056.1 - 3.2e-05 24.1 16.6 0.015 15.8 0.0 7.2 4 2 4 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70056.1 - 9.3e-05 22.9 22.8 0.016 15.9 0.2 6.5 7 1 0 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS70056.1 - 0.00088 19.5 4.6 1 9.9 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70056.1 - 0.021 14.7 19.1 0.2 11.5 0.0 5.5 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70056.1 - 0.078 12.8 7.7 4.5 7.3 0.0 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat XPC-binding PF09280.6 ESS70057.1 - 0.00038 19.8 0.0 0.001 18.4 0.0 1.7 1 0 0 1 1 1 1 XPC-binding domain zf-CCCH PF00642.19 ESS70059.1 - 3.3e-08 33.0 13.5 0.00056 19.5 2.3 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESS70059.1 - 0.0097 15.8 1.7 1.2 9.2 0.0 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type LRV_FeS PF05484.6 ESS70059.1 - 0.27 10.8 4.6 1.5 8.4 0.1 3.1 3 0 0 3 3 3 0 LRV protein FeS4 cluster Pkinase PF00069.20 ESS70060.1 - 1.9e-72 243.5 0.0 2.4e-72 243.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70060.1 - 1.4e-32 112.7 0.0 2e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70060.1 - 4.6e-06 25.8 0.0 1.8e-05 23.8 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 ESS70060.1 - 0.0055 16.4 3.7 0.56 9.9 0.0 3.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family HEAT_EZ PF13513.1 ESS70060.1 - 1.1 9.8 5.9 8.1 7.0 1.2 3.7 3 1 1 4 4 4 0 HEAT-like repeat LRR_4 PF12799.2 ESS70061.1 - 1.6e-15 56.3 1.3 5.5e-09 35.4 0.6 3.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70061.1 - 6.5e-09 35.4 0.2 1.5e-07 31.0 0.0 2.7 3 0 0 3 3 3 1 Leucine rich repeat LRR_9 PF14580.1 ESS70061.1 - 1.7e-08 34.2 0.1 3.7e-08 33.1 0.1 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_7 PF13504.1 ESS70061.1 - 6.8e-06 25.4 1.1 3.1 8.4 0.0 5.2 5 0 0 5 5 5 1 Leucine rich repeat LRR_6 PF13516.1 ESS70061.1 - 0.0026 17.6 1.1 3.7 7.8 0.0 4.3 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.28 ESS70061.1 - 0.0072 16.2 1.3 3.3 8.0 0.1 4.1 3 1 1 4 4 4 1 Leucine Rich Repeat CRA PF06589.6 ESS70062.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) PIG-U PF06728.8 ESS70063.1 - 0.00091 18.1 13.3 0.024 13.4 9.2 2.2 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U RNase_HII PF01351.13 ESS70064.1 - 8.1e-41 139.8 0.0 1.2e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease HII DUF3592 PF12158.3 ESS70065.1 - 1.4e-11 44.4 0.8 6.4e-11 42.2 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3592) DnaJ PF00226.26 ESS70066.1 - 1.8e-12 46.7 0.0 3.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Ribosomal_S27 PF01599.14 ESS70067.1 - 1.3e-21 76.1 2.4 1.3e-21 76.1 1.7 1.6 2 0 0 2 2 2 1 Ribosomal protein S27a IBR PF01485.16 ESS70067.1 - 0.0033 17.2 0.4 0.005 16.6 0.3 1.3 1 0 0 1 1 1 1 IBR domain CRAL_TRIO PF00650.15 ESS70068.1 - 3.5e-26 91.5 0.0 5.5e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CAP_GLY PF01302.20 ESS70068.1 - 2.6e-15 55.8 0.6 5.3e-15 54.8 0.4 1.5 1 0 0 1 1 1 1 CAP-Gly domain CRAL_TRIO_N PF03765.10 ESS70068.1 - 0.055 13.6 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain Trehalose_recp PF06151.8 ESS70068.1 - 0.082 11.2 0.1 0.11 10.8 0.1 1.1 1 0 0 1 1 1 0 Trehalose receptor EFG_C PF00679.19 ESS70069.1 - 9.8e-22 76.6 0.1 1.9e-21 75.7 0.0 1.5 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.13 ESS70069.1 - 9.3e-07 28.4 0.0 2e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU PF00009.22 ESS70070.1 - 2.4e-59 199.9 0.0 4.7e-59 198.9 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 ESS70070.1 - 8.6e-07 28.9 0.2 4.2e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.1 ESS70070.1 - 6.3e-05 22.7 0.0 0.00023 20.9 0.0 2.0 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 ESS70070.1 - 0.0021 17.9 0.0 0.0052 16.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF442 PF04273.8 ESS70070.1 - 0.007 16.2 0.0 2.5 8.0 0.0 2.5 2 0 0 2 2 2 2 Putative phosphatase (DUF442) AIG1 PF04548.11 ESS70070.1 - 0.045 12.8 0.0 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 AIG1 family Filament PF00038.16 ESS70071.1 - 2.4e-05 23.9 18.1 3.7e-05 23.3 12.5 1.2 1 0 0 1 1 1 1 Intermediate filament protein HALZ PF02183.13 ESS70071.1 - 0.00085 18.9 5.9 0.12 12.1 0.3 4.3 4 0 0 4 4 4 1 Homeobox associated leucine zipper Hemerythrin PF01814.18 ESS70071.1 - 0.032 14.4 0.7 0.28 11.3 0.0 2.6 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain Zein-binding PF04576.10 ESS70071.1 - 0.044 13.9 13.6 0.11 12.5 0.1 3.9 1 1 3 4 4 4 0 Zein-binding Orbi_VP5 PF00901.12 ESS70071.1 - 0.094 10.9 12.7 0.13 10.4 8.8 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Prefoldin PF02996.12 ESS70071.1 - 0.41 10.2 16.9 3 7.5 0.2 4.3 2 2 1 3 3 3 0 Prefoldin subunit TSC22 PF01166.13 ESS70071.1 - 1.7 8.6 18.0 8.2 6.4 0.0 5.6 5 1 1 6 6 6 0 TSC-22/dip/bun family APG6 PF04111.7 ESS70071.1 - 1.8 7.4 23.0 0.12 11.4 0.3 3.0 1 1 1 2 2 2 0 Autophagy protein Apg6 HrpB2 PF09487.5 ESS70071.1 - 2.2 8.4 6.9 3 8.0 0.1 3.3 2 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB2) Fib_alpha PF08702.5 ESS70071.1 - 9.9 6.2 16.9 11 6.1 3.6 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Pkinase PF00069.20 ESS70072.1 - 1.5e-78 263.5 0.0 1.8e-78 263.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70072.1 - 3.3e-35 121.4 0.0 4.9e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS70072.1 - 0.0024 17.6 0.2 0.0062 16.2 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS70072.1 - 0.022 14.0 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESS70072.1 - 0.034 13.0 0.0 4.4 6.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like ubiquitin PF00240.18 ESS70073.1 - 4.2e-08 32.4 0.0 6.6e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 ESS70073.1 - 6.7e-08 32.1 0.3 1.6e-07 30.9 0.2 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.3 ESS70073.1 - 0.033 13.8 0.0 0.066 12.9 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Cohesin_HEAT PF12765.2 ESS70073.1 - 0.059 13.3 1.2 0.86 9.6 0.1 2.9 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CUE PF02845.11 ESS70073.1 - 0.18 11.3 2.9 1.4 8.4 0.1 2.5 2 0 0 2 2 2 0 CUE domain TFIIA PF03153.8 ESS70073.1 - 3.1 7.6 14.5 4.1 7.2 10.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.20 ESS70074.1 - 8.7e-59 198.7 0.0 1.5e-58 197.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70074.1 - 9e-28 97.0 0.0 8.4e-19 67.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS70074.1 - 1.6e-07 30.6 0.1 0.0017 17.3 0.0 2.9 3 0 0 3 3 3 2 Kinase-like Seadorna_VP7 PF07387.6 ESS70074.1 - 0.0067 15.2 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 ESS70074.1 - 0.0095 15.0 0.1 0.015 14.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS70074.1 - 0.018 14.7 0.1 0.028 14.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESS70074.1 - 0.14 10.9 0.1 0.2 10.3 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PP2C PF00481.16 ESS70075.1 - 2.5e-72 243.3 0.0 3.1e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESS70075.1 - 0.00021 20.7 0.0 0.00032 20.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 ESS70075.1 - 0.0034 17.1 0.0 0.027 14.1 0.0 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Mito_carr PF00153.22 ESS70077.1 - 2.7e-90 296.2 12.1 3.3e-20 71.5 0.0 6.3 5 1 1 6 6 6 6 Mitochondrial carrier protein PspC PF04024.7 ESS70077.1 - 0.11 11.9 1.1 18 4.8 0.0 3.3 3 0 0 3 3 3 0 PspC domain TPR_11 PF13414.1 ESS70078.1 - 3.4e-35 119.5 26.3 2.6e-16 59.0 0.1 6.4 3 3 3 6 6 6 5 TPR repeat DnaJ PF00226.26 ESS70078.1 - 1.1e-19 69.8 0.9 1.1e-19 69.8 0.6 2.7 3 0 0 3 3 3 1 DnaJ domain TPR_1 PF00515.23 ESS70078.1 - 1.7e-17 62.2 22.8 0.00061 19.2 0.7 7.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70078.1 - 2.4e-17 61.3 25.0 0.0001 21.9 0.8 8.0 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70078.1 - 2.9e-15 56.4 30.9 1.3e-05 25.7 0.2 5.8 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESS70078.1 - 1.6e-10 41.1 16.7 0.00076 19.7 0.2 6.3 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70078.1 - 2.3e-08 33.9 22.9 0.3 11.8 0.2 8.3 5 2 4 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70078.1 - 3.4e-08 33.3 18.3 0.041 13.8 0.3 5.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70078.1 - 6.9e-07 28.6 14.3 0.85 9.5 0.2 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70078.1 - 7.3e-06 25.7 12.0 0.15 11.9 0.0 5.6 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS70078.1 - 1.5e-05 24.8 9.3 0.47 10.7 0.0 5.8 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70078.1 - 9.2e-05 21.9 14.4 0.025 14.3 0.4 5.9 7 0 0 7 7 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS70078.1 - 0.034 14.0 0.1 0.034 14.0 0.1 4.9 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat zf-C2HC_2 PF13913.1 ESS70079.1 - 1.6e-12 46.7 9.9 6.4e-08 32.0 1.3 2.5 2 0 0 2 2 2 2 zinc-finger of a C2HC-type GRP PF07172.6 ESS70079.1 - 0.038 14.4 2.1 0.038 14.4 1.5 2.3 2 0 0 2 2 2 0 Glycine rich protein family zf-C2H2_6 PF13912.1 ESS70079.1 - 0.076 12.9 2.8 2 8.4 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESS70079.1 - 0.092 13.1 1.5 17 6.0 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Apc11 PF12861.2 ESS70080.1 - 0.058 13.2 0.8 0.11 12.3 0.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Dus PF01207.12 ESS70081.1 - 6e-33 113.9 0.2 2.1e-31 108.9 0.1 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Hydrolase_6 PF13344.1 ESS70081.1 - 0.029 14.2 0.0 0.073 12.9 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Sec1 PF00995.18 ESS70082.1 - 5.4e-128 428.0 2.5 6.3e-128 427.8 1.8 1.0 1 0 0 1 1 1 1 Sec1 family DUF2106 PF09879.4 ESS70082.1 - 0.058 12.7 0.0 0.17 11.2 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2106) DUF4056 PF13265.1 ESS70083.1 - 0.3 10.0 1.2 0.45 9.4 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) FAST_1 PF06743.10 ESS70084.1 - 0.0021 17.7 0.8 0.26 11.0 0.1 3.4 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 1 ANTH PF07651.11 ESS70084.1 - 0.047 12.3 0.4 0.13 10.9 0.0 1.8 2 0 0 2 2 2 0 ANTH domain MMR_HSR1_C PF08438.5 ESS70084.1 - 0.13 12.4 0.0 0.37 11.0 0.0 1.7 1 0 0 1 1 1 0 GTPase of unknown function C-terminal DUF1469 PF07332.6 ESS70085.1 - 0.095 12.4 2.8 0.88 9.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) PDZ PF00595.19 ESS70086.1 - 3.5e-05 23.9 0.0 7.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 ESS70086.1 - 4.5e-05 23.2 0.0 0.0001 22.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Dodecin PF07311.7 ESS70086.1 - 0.029 14.4 0.3 0.094 12.7 0.0 1.9 2 0 0 2 2 2 0 Dodecin GRASP55_65 PF04495.9 ESS70086.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Lipase_GDSL_2 PF13472.1 ESS70089.1 - 3.2e-08 33.9 0.0 7.3e-08 32.7 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ESS70089.1 - 8.9e-06 25.6 0.0 4.1e-05 23.5 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Cu-binding_MopE PF11617.3 ESS70089.1 - 0.0021 17.7 6.1 0.0048 16.6 4.2 1.6 1 0 0 1 1 1 1 Protein metal binding site PIP5K PF01504.13 ESS70090.1 - 1.9e-61 207.3 0.0 3.7e-61 206.4 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF106 PF01956.11 ESS70091.1 - 9.4e-47 158.6 2.9 1.3e-46 158.1 2.0 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF106 RNase_HII PF01351.13 ESS70094.1 - 9.6e-26 90.6 0.0 3.5e-15 56.1 0.0 2.7 2 1 0 2 2 2 2 Ribonuclease HII Ank PF00023.25 ESS70095.1 - 4.4e-14 51.4 0.3 1.4e-06 27.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESS70095.1 - 1e-13 51.3 0.1 1.1e-06 28.9 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESS70095.1 - 1.3e-12 47.8 0.1 1.1e-06 28.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESS70095.1 - 4.5e-12 44.9 0.2 0.00011 22.0 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESS70095.1 - 1.5e-11 44.1 0.1 1.3e-07 31.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) WW PF00397.21 ESS70096.1 - 0.00078 19.2 0.4 0.0019 18.0 0.3 1.6 1 0 0 1 1 1 1 WW domain YCII PF03795.9 ESS70096.1 - 0.095 12.9 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 YCII-related domain ESCRT-II PF05871.7 ESS70097.1 - 4.6e-10 39.5 0.0 2e-09 37.4 0.0 1.9 1 1 0 1 1 1 1 ESCRT-II complex subunit NUDIX PF00293.23 ESS70098.1 - 1.9e-15 56.6 0.0 2.7e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain CH PF00307.26 ESS70101.1 - 3.5e-08 33.4 0.0 0.0067 16.4 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 ESS70101.1 - 0.014 15.0 0.3 7 6.3 0.0 2.8 2 1 0 2 2 2 0 CAMSAP CH domain Paf67 PF10255.4 ESS70102.1 - 1.1e-91 307.7 0.0 1.5e-91 307.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 ESS70102.1 - 0.068 13.1 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.21 ESS70103.1 - 1.2e-34 119.4 0.0 1.6e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESS70103.1 - 3.7e-13 49.7 0.0 5.6e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESS70103.1 - 2e-05 23.8 0.0 2.6e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 ESS70103.1 - 3.9e-05 23.0 0.0 5.8e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 NTP_transf_3 PF12804.2 ESS70103.1 - 6.2e-05 23.1 0.0 8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glyco_tranf_2_4 PF13704.1 ESS70103.1 - 0.0043 17.3 0.1 0.01 16.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 ESS70103.1 - 0.013 15.2 0.0 0.013 15.2 0.0 2.2 1 1 1 2 2 2 0 Glycosyl transferase family group 2 DUF1201 PF06716.6 ESS70103.1 - 2.1 8.1 4.7 3.9 7.3 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) SET PF00856.23 ESS70104.1 - 2.6e-11 44.0 0.2 3.6e-09 37.1 0.1 2.6 1 1 0 1 1 1 1 SET domain Methyltransf_31 PF13847.1 ESS70105.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.6 ESS70105.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase GTP_EFTU PF00009.22 ESS70106.1 - 8.7e-62 207.9 0.2 1.5e-61 207.1 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESS70106.1 - 3.7e-35 120.0 0.0 9.1e-35 118.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 ESS70106.1 - 4.8e-14 51.9 0.1 2.3e-13 49.7 0.0 2.2 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESS70106.1 - 9.1e-14 51.3 0.1 3.2e-13 49.5 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MtlR PF05068.7 ESS70107.1 - 0.082 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Mannitol repressor DUF3317 PF11779.3 ESS70107.1 - 0.084 12.3 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) His_Phos_1 PF00300.17 ESS70108.1 - 6.6e-29 101.0 0.0 9.9e-29 100.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PUB PF09409.5 ESS70109.1 - 4.6e-14 51.9 0.0 1.1e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 PUB domain KNOX2 PF03791.8 ESS70109.1 - 0.045 13.0 0.0 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 KNOX2 domain Pox_MCEL PF03291.11 ESS70110.1 - 1.5e-34 119.3 0.1 1.2e-24 86.8 0.1 2.1 2 0 0 2 2 2 2 mRNA capping enzyme Methyltransf_12 PF08242.7 ESS70110.1 - 0.0032 17.9 0.0 0.0053 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ycf54 PF10674.4 ESS70111.1 - 0.055 13.5 1.3 0.18 11.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2488) DUF896 PF05979.7 ESS70111.1 - 0.095 12.3 1.0 0.83 9.2 0.0 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) IMS PF00817.15 ESS70112.1 - 7.5e-33 113.4 0.5 1.6e-32 112.3 0.1 1.7 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.3 ESS70112.1 - 1.8e-10 40.8 0.0 8e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 ESS70112.1 - 4.8e-06 26.2 0.0 0.00027 20.8 0.0 2.8 2 0 0 2 2 2 1 IMS family HHH motif LCM PF04072.9 ESS70114.1 - 4.7e-25 88.2 0.1 7.3e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase PGM_PMM_I PF02878.11 ESS70114.1 - 0.16 11.4 0.0 0.57 9.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I TPR_11 PF13414.1 ESS70115.1 - 1.2e-43 146.6 19.1 3.1e-17 61.9 1.8 4.1 3 1 1 4 4 4 4 TPR repeat TPR_1 PF00515.23 ESS70115.1 - 3.1e-39 131.0 17.6 3.5e-08 32.7 0.1 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70115.1 - 1.1e-33 112.3 15.4 1.1e-06 28.1 0.1 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70115.1 - 2.7e-19 67.4 16.6 1.5e-05 24.4 0.2 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70115.1 - 9.7e-16 57.4 13.4 0.00025 20.9 0.1 4.6 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70115.1 - 1.7e-15 56.0 1.6 0.0067 16.9 0.0 5.0 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70115.1 - 2.5e-15 56.6 4.3 0.00012 22.6 0.1 4.1 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70115.1 - 1.3e-13 50.5 2.3 0.00029 20.6 0.1 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat Apc3 PF12895.2 ESS70115.1 - 8.3e-12 45.0 11.1 1.3e-05 25.2 2.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESS70115.1 - 2.1e-11 43.5 8.5 0.0045 17.3 0.3 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70115.1 - 2.2e-10 39.5 9.3 0.03 14.1 0.1 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS70115.1 - 1.3e-09 37.5 16.5 0.03 14.4 0.2 5.3 7 0 0 7 7 4 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESS70115.1 - 2.1e-09 37.5 7.0 0.14 12.5 0.1 4.6 3 2 1 4 4 4 3 Tetratricopeptide repeat MIT PF04212.13 ESS70115.1 - 2.7e-08 33.5 4.8 0.018 14.9 0.1 4.5 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.2 ESS70115.1 - 1.1e-05 25.2 5.6 0.12 12.2 0.0 4.2 2 2 1 3 3 3 1 Domain of Unknown Function (DUF3856) TPR_15 PF13429.1 ESS70115.1 - 0.00065 18.8 2.7 0.58 9.1 0.1 4.3 2 2 2 4 4 4 1 Tetratricopeptide repeat TOM20_plant PF06552.7 ESS70115.1 - 0.023 14.3 0.6 27 4.2 0.0 3.4 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 SPO22 PF08631.5 ESS70115.1 - 0.024 13.7 1.1 12 4.8 0.0 3.1 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like SNAP PF14938.1 ESS70115.1 - 0.029 13.5 14.4 0.93 8.5 4.9 3.5 1 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP Sec5 PF15469.1 ESS70115.1 - 0.039 13.6 0.8 4.8 6.8 0.1 3.3 2 1 1 3 3 3 0 Exocyst complex component Sec5 NYD-SP12_N PF15015.1 ESS70115.1 - 0.064 11.4 0.0 0.11 10.7 0.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal DNA_pol3_delta2 PF13177.1 ESS70115.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit TPR_3 PF07720.7 ESS70115.1 - 0.17 11.6 6.9 0.9 9.4 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat NARP1 PF12569.3 ESS70115.1 - 0.5 9.0 5.3 8.6 4.9 0.1 2.9 1 1 0 3 3 3 0 NMDA receptor-regulated protein 1 NSF PF02071.15 ESS70115.1 - 1.6 9.6 6.7 8.9 7.3 0.1 5.1 4 2 2 6 6 3 0 Aromatic-di-Alanine (AdAR) repeat FGGY_C PF02782.11 ESS70116.1 - 1.6e-39 135.6 0.1 2.2e-39 135.1 0.1 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain HSP70 PF00012.15 ESS70116.1 - 0.015 13.2 0.2 0.02 12.8 0.1 1.1 1 0 0 1 1 1 0 Hsp70 protein BcrAD_BadFG PF01869.15 ESS70116.1 - 0.02 14.2 0.1 0.038 13.2 0.0 1.5 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family PUF PF00806.14 ESS70117.1 - 2e-30 102.5 7.8 1.1e-05 24.5 0.0 7.4 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat Seryl_tRNA_N PF02403.17 ESS70117.1 - 0.44 10.5 5.1 0.42 10.6 1.5 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Amidohydro_1 PF01979.15 ESS70118.1 - 5.5e-09 36.1 0.0 0.00043 20.0 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 ESS70118.1 - 1.1e-08 35.4 0.1 4.7e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 ESS70118.1 - 3.3e-07 30.0 0.1 7.9e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 ESS70118.1 - 4.4e-06 26.1 0.1 0.058 12.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Nop10p PF04135.7 ESS70119.1 - 1.3e-21 76.0 0.3 1.6e-21 75.7 0.2 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family FKBP_C PF00254.23 ESS70120.1 - 7.7e-27 93.1 0.0 8.6e-27 92.9 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CelD_N PF02927.9 ESS70120.1 - 0.1 12.8 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 N-terminal ig-like domain of cellulase TFIIS_M PF07500.9 ESS70121.1 - 0.016 15.2 0.5 0.059 13.4 0.3 2.0 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain Dynein_light PF01221.13 ESS70122.1 - 1.7e-27 95.1 2.0 2e-27 94.9 1.4 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 YtxH PF12732.2 ESS70122.1 - 0.051 13.9 0.1 0.066 13.5 0.0 1.2 1 0 0 1 1 1 0 YtxH-like protein DUF922 PF06037.6 ESS70122.1 - 0.062 12.6 0.4 0.078 12.3 0.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Ground-like PF04155.13 ESS70122.1 - 0.087 13.1 0.1 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Ground-like domain Mlp PF03304.8 ESS70122.1 - 0.11 12.4 0.4 0.2 11.6 0.2 1.4 1 1 0 1 1 1 0 Mlp lipoprotein family Proteasome PF00227.21 ESS70123.1 - 1.1e-30 106.3 0.2 1.3e-30 106.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_S24 PF00717.18 ESS70125.1 - 6.6e-09 35.3 0.0 9.4e-09 34.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like Etmic-2 PF06670.6 ESS70127.1 - 0.061 12.0 1.6 0.064 11.9 1.1 1.1 1 0 0 1 1 1 0 Microneme protein Etmic-2 DUF4131 PF13567.1 ESS70156.1 - 1.4 8.3 4.1 1.6 8.1 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Draxin PF15550.1 ESS70157.1 - 0.68 9.5 15.3 0.81 9.2 10.6 1.0 1 0 0 1 1 1 0 Draxin CRT10 PF08728.5 ESS70157.1 - 1.5 6.7 7.2 1.8 6.4 5.0 1.0 1 0 0 1 1 1 0 CRT10 Mucin PF01456.12 ESS70157.1 - 2.7 7.7 20.7 0.023 14.4 4.5 2.5 2 1 0 2 2 2 0 Mucin-like glycoprotein SOBP PF15279.1 ESS70157.1 - 5.1 7.3 7.6 6.1 7.1 5.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein CDC27 PF09507.5 ESS70157.1 - 8.4 5.4 31.7 11 5.1 22.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Parvo_coat PF00740.13 ESS70157.1 - 8.8 5.1 12.0 11 4.8 8.3 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 DUF4337 PF14235.1 ESS70158.1 - 0.1 12.4 0.9 0.11 12.2 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) BNR_3 PF13859.1 ESS70159.1 - 4.6e-131 436.4 1.9 4.6e-131 436.4 1.3 1.5 2 0 0 2 2 2 1 BNR repeat-like domain UPF0104 PF03706.8 ESS70162.1 - 1.2 8.4 12.6 2.4 7.3 1.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0104) YIF1 PF03878.10 ESS70163.1 - 1.1e-30 106.5 0.2 1.7e-30 105.9 0.2 1.2 1 0 0 1 1 1 1 YIF1 Myb_DNA-binding PF00249.26 ESS70164.1 - 0.003 17.5 0.5 0.016 15.2 0.3 2.2 2 1 1 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESS70164.1 - 0.01 15.9 0.1 0.017 15.1 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain DnaJ PF00226.26 ESS70165.1 - 5.7e-18 64.4 0.2 1.3e-17 63.3 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain RPN7 PF10602.4 ESS70165.1 - 0.026 13.9 3.6 0.066 12.5 2.5 1.6 1 0 0 1 1 1 0 26S proteasome subunit RPN7 SpoVR PF04293.8 ESS70165.1 - 0.24 9.7 8.4 0.41 8.9 5.8 1.4 1 0 0 1 1 1 0 SpoVR like protein CAF-1_p150 PF11600.3 ESS70165.1 - 2.7 7.3 38.9 5.2 6.3 27.0 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PI3_PI4_kinase PF00454.22 ESS70166.1 - 1.7e-43 148.7 0.1 4e-43 147.5 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ESS70166.1 - 7.6e-32 110.6 5.4 7.6e-32 110.6 3.8 2.6 3 0 0 3 3 3 1 FAT domain FATC PF02260.15 ESS70166.1 - 4.8e-11 41.8 0.1 1e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 FATC domain HEAT PF02985.17 ESS70166.1 - 0.0035 17.3 5.8 6.5 7.1 0.0 6.4 6 0 0 6 6 6 1 HEAT repeat TPR_7 PF13176.1 ESS70166.1 - 0.081 12.7 0.0 6.3 6.8 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MORN PF02493.15 ESS70168.1 - 6.5e-08 31.8 20.0 0.00052 19.5 1.1 4.9 6 0 0 6 6 6 3 MORN repeat AAA PF00004.24 ESS70169.1 - 1.6e-05 25.1 0.9 8.1e-05 22.8 0.0 2.6 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS70169.1 - 5.7e-05 23.9 0.5 0.00039 21.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESS70169.1 - 6.7e-05 22.9 0.0 0.0002 21.3 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESS70169.1 - 0.022 14.9 0.1 0.98 9.5 0.0 2.9 1 1 1 2 2 2 0 AAA domain Arch_ATPase PF01637.13 ESS70169.1 - 0.043 13.4 0.2 0.13 11.9 0.0 1.9 1 1 0 1 1 1 0 Archaeal ATPase AAA_14 PF13173.1 ESS70169.1 - 0.077 12.8 0.0 16 5.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 ESS70169.1 - 0.078 12.7 0.1 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESS70169.1 - 0.11 12.3 1.4 0.44 10.3 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain zf-rbx1 PF12678.2 ESS70170.1 - 1e-05 25.5 4.5 2.4e-05 24.3 3.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESS70170.1 - 1.5e-05 24.7 3.2 5e-05 23.0 2.2 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS70170.1 - 0.011 15.7 2.8 0.041 13.9 1.9 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESS70170.1 - 3.2 7.6 10.7 0.36 10.6 4.1 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 ESS70170.1 - 4.1 7.2 12.8 0.058 13.1 3.3 2.2 2 1 0 2 2 2 0 zinc-RING finger domain Pup PF05639.6 ESS70172.1 - 9.3 6.8 7.0 0.61 10.6 0.3 2.4 3 0 0 3 3 3 0 Pup-like protein DUF1700 PF08006.6 ESS70173.1 - 0.25 10.6 4.3 0.27 10.4 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) PRT_C PF08372.5 ESS70173.1 - 1.2 8.6 4.3 1.2 8.5 3.0 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal PIN_4 PF13638.1 ESS70176.1 - 1.8e-10 41.0 0.3 8e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 PIN domain Nop25 PF09805.4 ESS70177.1 - 0.044 13.8 17.4 0.053 13.6 8.9 2.4 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) MIP-T3 PF10243.4 ESS70177.1 - 3.2 6.1 33.9 4.4 5.6 23.5 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Hist_rich_Ca-bd PF10529.4 ESS70178.1 - 1.2 9.1 5.8 4 7.5 4.0 1.9 1 0 0 1 1 1 0 Histidine-rich Calcium-binding repeat region EF-hand_like PF09279.6 ESS70178.1 - 1.7 8.7 4.0 2.5 8.2 0.5 2.3 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like Pkinase PF00069.20 ESS70179.1 - 3.5e-52 177.1 0.0 7e-35 120.4 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70179.1 - 3.7e-33 114.7 0.0 9.8e-33 113.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESS70179.1 - 0.035 13.1 0.0 0.073 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PX PF00787.19 ESS70179.1 - 0.074 12.8 0.2 0.22 11.3 0.1 1.7 1 0 0 1 1 1 0 PX domain DUF4379 PF14311.1 ESS70180.1 - 4.9e-21 74.2 8.0 1.9e-15 56.4 2.5 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4379) Pro_isomerase PF00160.16 ESS70181.1 - 0.00035 20.7 0.0 0.00087 19.5 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD AATF-Che1 PF13339.1 ESS70184.1 - 8.5e-10 38.8 0.1 8.5e-10 38.8 0.1 3.9 3 2 1 4 4 4 1 Apoptosis antagonizing transcription factor V_ATPase_I PF01496.14 ESS70184.1 - 1.1 6.9 3.5 2.5 5.8 2.4 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Elf1 PF05129.8 ESS70185.1 - 6.4e-06 25.7 2.7 6.4e-06 25.7 1.9 2.6 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like Ribonuclease_3 PF00636.21 ESS70185.1 - 0.024 15.0 0.0 0.13 12.7 0.0 2.2 1 1 0 1 1 1 0 Ribonuclease III domain Cys_rich_CPXG PF14255.1 ESS70185.1 - 0.039 13.7 2.3 0.11 12.3 1.6 1.8 1 0 0 1 1 1 0 Cysteine-rich CPXCG SUV3_C PF12513.3 ESS70185.1 - 0.041 13.3 0.0 0.088 12.2 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal DEAD PF00270.24 ESS70186.1 - 4.8e-29 101.0 0.1 3.3e-14 52.7 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS70186.1 - 2.4e-13 49.7 0.0 4.4e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS70186.1 - 1.3e-07 31.6 0.0 3.6e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1009 PF06230.6 ESS70187.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1009) TruD PF01142.13 ESS70188.1 - 1.3e-18 66.8 0.0 6.8e-16 57.8 0.0 3.3 3 0 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) SCO1-SenC PF02630.9 ESS70189.1 - 2.1e-30 105.6 0.0 4.8e-29 101.1 0.0 2.3 1 1 0 1 1 1 1 SCO1/SenC PAP_RNA-bind PF04926.10 ESS70189.1 - 0.043 13.3 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain DUF4131 PF13567.1 ESS70190.1 - 0.33 10.3 4.1 0.56 9.5 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3566 PF12089.3 ESS70190.1 - 2 8.4 4.7 1.7 8.6 1.3 2.2 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) IncA PF04156.9 ESS70190.1 - 6.7 6.2 5.9 13 5.3 4.1 1.4 1 0 0 1 1 1 0 IncA protein AAA PF00004.24 ESS70191.1 - 1.5e-52 177.2 0.0 2.1e-36 125.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESS70191.1 - 3e-12 47.3 0.5 2e-05 25.3 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ESS70191.1 - 2.2e-09 37.5 1.5 0.016 15.3 0.4 4.1 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ESS70191.1 - 2.5e-08 34.2 0.0 0.0037 17.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESS70191.1 - 3.9e-08 33.1 0.0 0.0011 18.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.8 ESS70191.1 - 1.4e-07 30.5 0.0 0.0086 14.8 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_19 PF13245.1 ESS70191.1 - 2.1e-07 30.5 0.1 0.0024 17.5 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain AAA_16 PF13191.1 ESS70191.1 - 4.3e-07 30.0 0.1 0.012 15.5 0.0 3.2 2 1 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.1 ESS70191.1 - 1.5e-06 28.1 0.0 0.045 13.6 0.0 3.4 3 1 1 4 4 3 2 AAA domain Mg_chelatase PF01078.16 ESS70191.1 - 3.7e-05 22.9 0.1 0.0047 16.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 ESS70191.1 - 4.4e-05 23.3 0.0 0.042 13.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESS70191.1 - 0.00012 22.2 0.0 0.35 11.0 0.0 2.6 2 0 0 2 2 2 2 RNA helicase RuvB_N PF05496.7 ESS70191.1 - 0.00013 21.0 0.0 0.074 12.0 0.0 2.5 3 0 0 3 3 2 1 Holliday junction DNA helicase ruvB N-terminus KTI12 PF08433.5 ESS70191.1 - 0.0005 19.3 0.0 0.14 11.3 0.0 2.4 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_3 PF07726.6 ESS70191.1 - 0.00058 19.4 0.0 0.34 10.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 ESS70191.1 - 0.00059 18.9 0.0 0.26 10.2 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 ESS70191.1 - 0.00065 19.1 0.1 0.09 12.1 0.0 3.0 3 0 0 3 3 3 1 IstB-like ATP binding protein NACHT PF05729.7 ESS70191.1 - 0.00074 19.2 0.2 2.6 7.6 0.1 3.6 3 1 0 3 3 3 1 NACHT domain Sigma54_activat PF00158.21 ESS70191.1 - 0.0012 18.2 0.1 0.89 9.0 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 ESS70191.1 - 0.0016 17.5 0.1 0.95 8.5 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 ESS70191.1 - 0.0035 16.7 2.1 4 6.8 0.0 3.5 4 0 0 4 4 4 1 AAA domain Sigma54_activ_2 PF14532.1 ESS70191.1 - 0.0039 17.2 0.0 2.7 8.0 0.0 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_2 PF07724.9 ESS70191.1 - 0.0047 16.8 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.1 ESS70191.1 - 0.0058 16.2 0.2 0.2 11.2 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESS70191.1 - 0.0063 16.4 0.0 3.8 7.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 ESS70191.1 - 0.011 14.8 0.0 0.61 9.1 0.0 2.5 2 0 0 2 2 2 0 KaiC CDC48_N PF02359.13 ESS70191.1 - 0.02 14.8 0.0 0.055 13.4 0.0 1.8 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain AAA_30 PF13604.1 ESS70191.1 - 0.057 12.9 0.0 7.5 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 ESS70191.1 - 0.071 12.6 0.0 2.9 7.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain SKI PF01202.17 ESS70191.1 - 0.078 12.8 0.0 4.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Shikimate kinase ABC_tran PF00005.22 ESS70191.1 - 0.08 13.2 0.1 17 5.6 0.0 3.2 2 1 1 3 3 3 0 ABC transporter Thymidylate_kin PF02223.12 ESS70191.1 - 0.083 12.2 0.0 2.5 7.4 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase PhoH PF02562.11 ESS70191.1 - 0.1 11.7 0.1 1.4 8.0 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.24 ESS70191.1 - 0.11 11.9 1.0 7.9 5.9 0.0 3.2 3 1 1 4 4 4 0 DEAD/DEAH box helicase NB-ARC PF00931.17 ESS70191.1 - 0.19 10.5 1.0 3.2 6.5 0.1 2.7 2 1 0 3 3 3 0 NB-ARC domain TTL PF03133.10 ESS70192.1 - 3.8e-56 190.1 0.0 5.7e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 ESS70192.1 - 0.018 14.7 0.0 0.057 13.1 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain ATPgrasp_YheCD PF14398.1 ESS70192.1 - 0.12 11.1 0.0 0.3 9.8 0.0 1.6 1 1 0 1 1 1 0 YheC/D like ATP-grasp ATPgrasp_Ter PF15632.1 ESS70192.1 - 0.18 10.5 0.0 0.35 9.5 0.0 1.5 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon Tubulin_3 PF14881.1 ESS70193.1 - 0.00019 20.9 0.0 0.00034 20.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 ESS70193.1 - 0.0017 18.3 0.0 0.0042 17.1 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Pkinase PF00069.20 ESS70194.1 - 2.1e-60 204.0 0.0 3.8e-60 203.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70194.1 - 3.5e-38 131.1 0.0 5.3e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.24 ESS70194.1 - 2.2e-10 40.2 0.1 0.0001 22.0 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Kinase-like PF14531.1 ESS70194.1 - 1.7e-08 33.7 0.0 1.9e-07 30.3 0.0 2.2 1 1 0 2 2 2 1 Kinase-like PAS PF00989.19 ESS70194.1 - 1.5e-06 27.9 0.0 4.8e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 ESS70194.1 - 0.00058 20.2 0.0 0.0028 17.9 0.0 2.1 2 0 0 2 2 2 1 PAS domain DUF2975 PF11188.3 ESS70195.1 - 0.002 17.8 1.0 0.0024 17.5 0.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2975) Ribosomal_60s PF00428.14 ESS70197.1 - 0.066 13.6 1.2 8.7 6.8 0.0 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF547 PF04784.9 ESS70197.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF547 CAF-1_p150 PF11600.3 ESS70198.1 - 0.57 9.5 30.2 0.75 9.1 20.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF2011 PF09428.5 ESS70198.1 - 4.8 7.0 28.7 6.7 6.6 19.9 1.2 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) Tfb2 PF03849.9 ESS70202.1 - 0.0018 17.0 0.5 0.0023 16.6 0.3 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 ARGLU PF15346.1 ESS70202.1 - 0.005 16.6 7.7 0.007 16.1 5.3 1.1 1 0 0 1 1 1 1 Arginine and glutamate-rich 1 Mnd1 PF03962.10 ESS70202.1 - 0.029 14.0 1.9 0.043 13.4 1.3 1.2 1 0 0 1 1 1 0 Mnd1 family Fib_alpha PF08702.5 ESS70202.1 - 0.19 11.8 2.8 0.32 11.1 1.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HEAT PF02985.17 ESS70203.1 - 1.6e-31 105.5 28.4 0.0013 18.6 0.0 12.6 13 0 0 13 13 13 8 HEAT repeat HEAT_2 PF13646.1 ESS70203.1 - 6.3e-31 106.5 15.7 6.1e-08 32.8 0.3 6.5 2 1 4 7 7 7 7 HEAT repeats HEAT_EZ PF13513.1 ESS70203.1 - 3.4e-13 49.6 20.3 0.0054 17.1 0.0 9.7 8 3 2 10 10 10 3 HEAT-like repeat Adaptin_N PF01602.15 ESS70203.1 - 7.1e-06 24.6 4.1 0.008 14.5 0.3 3.7 1 1 1 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 ESS70203.1 - 2.6e-05 24.5 1.7 2.9 8.3 0.0 6.0 2 2 4 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 ESS70203.1 - 0.0027 17.5 5.0 2.8 7.7 0.0 4.8 2 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.9 ESS70203.1 - 0.3 10.1 3.1 21 4.0 0.0 3.3 3 1 1 4 4 4 0 V-ATPase subunit H TPR_14 PF13428.1 ESS70204.1 - 4.8e-05 23.6 9.4 0.29 11.8 0.0 6.4 5 1 2 7 7 7 2 Tetratricopeptide repeat Suf PF05843.9 ESS70204.1 - 7.3e-05 22.6 1.8 0.044 13.5 0.0 3.4 2 2 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_16 PF13432.1 ESS70204.1 - 0.0024 18.5 2.7 0.83 10.3 0.0 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS70204.1 - 0.006 16.1 1.8 0.26 10.9 0.3 3.2 3 1 0 3 3 3 1 TPR repeat TPR_19 PF14559.1 ESS70204.1 - 0.5 10.7 5.3 4 7.8 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat Kinesin PF00225.18 ESS70205.1 - 6.2e-100 334.1 0.0 2.1e-99 332.4 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain PglZ PF08665.7 ESS70205.1 - 0.023 14.3 1.5 1.3 8.6 0.4 3.0 3 0 0 3 3 3 0 PglZ domain AAA_24 PF13479.1 ESS70205.1 - 0.038 13.5 0.0 0.083 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain FG-GAP PF01839.18 ESS70208.1 - 5.6e-05 22.7 0.1 0.00011 21.7 0.1 1.5 1 0 0 1 1 1 1 FG-GAP repeat BBS2_Mid PF14783.1 ESS70208.1 - 0.0024 17.6 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region NTP_transf_2 PF01909.18 ESS70209.1 - 1e-05 25.7 0.0 1.9e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyltransferase domain DUF2572 PF10833.3 ESS70212.1 - 0.0066 15.8 0.2 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2572) Macoilin PF09726.4 ESS70212.1 - 0.081 11.1 5.6 0.15 10.3 3.9 1.3 1 0 0 1 1 1 0 Transmembrane protein Reo_sigmaC PF04582.7 ESS70212.1 - 0.31 10.1 2.6 0.53 9.4 1.8 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DivIC PF04977.10 ESS70212.1 - 1.1 8.7 8.8 2 7.9 3.5 2.6 2 0 0 2 2 2 0 Septum formation initiator S-methyl_trans PF02574.11 ESS70213.1 - 1.8e-31 109.5 0.0 4.3e-21 75.5 0.0 3.8 3 1 0 3 3 3 3 Homocysteine S-methyltransferase CTP_synth_N PF06418.9 ESS70214.1 - 5.5e-108 360.2 0.0 7.2e-108 359.8 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 ESS70214.1 - 5.1e-35 120.6 0.0 8.6e-35 119.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESS70214.1 - 9.6e-07 28.4 0.1 2.9e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 Peptidase C26 CbiA PF01656.18 ESS70214.1 - 0.0036 16.7 0.0 0.0056 16.1 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NAAA-beta PF15508.1 ESS70214.1 - 0.068 13.5 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DnaJ PF00226.26 ESS70215.1 - 0.00049 19.7 0.2 0.00088 18.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESS70215.1 - 0.00075 19.4 4.2 0.0015 18.5 2.9 1.5 1 0 0 1 1 1 1 DnaJ central domain Tox-HNH-HHH PF15637.1 ESS70215.1 - 0.084 12.6 0.0 0.21 11.4 0.0 1.6 1 1 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Zn_Tnp_IS91 PF14319.1 ESS70215.1 - 0.16 11.4 1.6 0.43 10.1 1.1 1.6 1 0 0 1 1 1 0 Transposase zinc-binding domain MORN PF02493.15 ESS70216.1 - 3.8e-25 86.0 31.5 9.4e-06 25.0 0.5 9.7 10 0 0 10 10 10 8 MORN repeat CinA PF02464.12 ESS70218.1 - 0.0046 16.4 0.1 0.0092 15.4 0.1 1.5 1 0 0 1 1 1 1 Competence-damaged protein CTP_transf_2 PF01467.21 ESS70218.1 - 0.023 14.7 0.1 0.16 11.9 0.0 2.2 1 1 0 1 1 1 0 Cytidylyltransferase PPR_2 PF13041.1 ESS70219.1 - 3.4e-12 46.1 0.1 0.011 15.7 0.0 4.3 2 1 2 4 4 4 4 PPR repeat family PPR PF01535.15 ESS70219.1 - 1e-07 31.4 0.6 0.0012 18.6 0.0 3.7 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.1 ESS70219.1 - 5.1e-06 26.3 5.0 0.043 14.0 0.0 5.0 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESS70219.1 - 0.00016 21.0 0.1 0.00053 19.3 0.1 1.9 1 0 0 1 1 1 1 PPR repeat Tubulin PF00091.20 ESS70220.1 - 2e-54 184.7 0.0 2.6e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.1 ESS70220.1 - 0.0033 16.4 0.0 0.006 15.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin like TM231 PF10149.4 ESS70221.1 - 1.2e-10 40.8 1.5 6.4e-06 25.3 0.0 2.2 2 0 0 2 2 2 2 Transmembrane protein 231 DAO PF01266.19 ESS70222.1 - 4.7e-25 88.2 0.5 6e-25 87.8 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESS70222.1 - 1.2e-07 30.9 0.1 2.4e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 ESS70222.1 - 3.2e-06 25.8 0.4 4.8e-06 25.3 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.2 ESS70222.1 - 7.6e-06 25.2 1.7 1.2e-05 24.6 1.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESS70222.1 - 9.1e-05 22.4 0.1 0.00021 21.2 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESS70222.1 - 0.00015 21.7 0.8 0.00041 20.3 0.3 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 ESS70222.1 - 0.0011 17.9 0.2 0.0019 17.1 0.2 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 ESS70222.1 - 0.018 15.1 0.1 0.083 12.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESS70222.1 - 0.019 14.0 0.2 0.035 13.1 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.7 ESS70222.1 - 0.02 13.8 0.7 0.035 13.0 0.5 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.22 ESS70222.1 - 0.025 14.9 0.1 0.068 13.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESS70222.1 - 0.051 12.6 0.1 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.13 ESS70222.1 - 0.073 12.7 0.7 0.15 11.7 0.5 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_8 PF05148.10 ESS70223.1 - 4.2e-50 170.4 0.0 5.6e-50 170.0 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 ESS70223.1 - 1.9e-07 31.4 0.0 5.9e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS70223.1 - 0.00046 19.9 0.0 0.00092 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS70223.1 - 0.0011 18.1 0.0 0.0018 17.4 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 ESS70223.1 - 0.07 12.7 0.1 6.5 6.3 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain Reo_sigmaC PF04582.7 ESS70224.1 - 7.1 5.7 18.0 0.14 11.3 2.3 3.2 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF2946 PF11162.3 ESS70226.1 - 1.8e-15 57.2 0.2 1.8e-15 57.2 0.1 1.8 2 1 1 3 3 2 1 Protein of unknown function (DUF2946) Adeno_E3_CR2 PF02439.10 ESS70226.1 - 0.0013 18.2 3.6 0.0027 17.2 2.5 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Mid2 PF04478.7 ESS70226.1 - 0.004 16.5 0.1 0.0072 15.7 0.1 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor TMEM154 PF15102.1 ESS70226.1 - 0.014 15.1 0.2 0.028 14.1 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family Rax2 PF12768.2 ESS70226.1 - 0.019 14.2 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Shisa PF13908.1 ESS70226.1 - 0.041 14.0 0.1 0.041 14.0 0.0 1.8 2 1 0 2 2 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.1 ESS70226.1 - 0.051 13.9 1.7 0.066 13.6 0.1 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Herpes_gE PF02480.11 ESS70226.1 - 0.06 11.6 0.5 0.12 10.6 0.0 1.6 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DAG1 PF05454.6 ESS70226.1 - 0.064 12.4 0.0 0.064 12.4 0.0 1.6 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) GAPT PF11770.3 ESS70226.1 - 0.071 12.7 3.4 0.41 10.3 0.4 2.8 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) SIT PF15330.1 ESS70226.1 - 0.078 13.1 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT WBP-1 PF11669.3 ESS70226.1 - 0.09 12.8 0.1 0.09 12.8 0.1 2.9 3 0 0 3 3 2 0 WW domain-binding protein 1 Orthoreo_P10 PF07204.6 ESS70226.1 - 0.096 12.4 1.4 0.12 12.1 0.1 1.7 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Tweety PF04906.8 ESS70226.1 - 0.099 11.0 0.1 0.2 10.0 0.1 1.4 1 0 0 1 1 1 0 Tweety DUF4381 PF14316.1 ESS70226.1 - 0.12 12.4 1.9 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Neurensin PF14927.1 ESS70226.1 - 0.14 11.5 0.0 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 Neurensin IncA PF04156.9 ESS70226.1 - 0.14 11.7 0.1 0.26 10.8 0.1 1.4 1 0 0 1 1 1 0 IncA protein TMEM52 PF14979.1 ESS70226.1 - 0.18 11.7 0.2 0.18 11.7 0.1 1.7 2 0 0 2 2 2 0 Transmembrane 52 Rifin_STEVOR PF02009.11 ESS70226.1 - 0.31 10.6 1.4 0.5 9.9 1.0 1.2 1 0 0 1 1 1 0 Rifin/stevor family Rad1 PF02144.11 ESS70227.1 - 3.2e-09 35.9 0.0 3.2e-08 32.6 0.0 1.9 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Lin-8 PF03353.10 ESS70228.1 - 0.24 10.6 2.0 0.46 9.7 1.4 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MFS_1 PF07690.11 ESS70229.1 - 1e-22 80.3 38.0 1.1e-16 60.4 6.6 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily HEAT_2 PF13646.1 ESS70230.1 - 0.00017 21.7 4.1 0.018 15.2 0.2 4.6 5 0 0 5 5 5 1 HEAT repeats Tfb2 PF03849.9 ESS70230.1 - 0.054 12.1 0.0 0.13 10.8 0.0 1.6 2 0 0 2 2 2 0 Transcription factor Tfb2 Acetyltransf_13 PF13880.1 ESS70231.1 - 2.1e-24 85.0 0.0 3.6e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_1 PF00583.19 ESS70231.1 - 0.0014 18.5 0.1 0.0055 16.7 0.0 2.0 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESS70231.1 - 0.097 12.7 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESS70231.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-C3HC4_3 PF13920.1 ESS70232.1 - 0.0056 16.3 8.6 0.012 15.3 6.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS70232.1 - 0.076 13.0 8.9 0.18 11.8 6.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS70232.1 - 1.7 8.3 7.6 3.3 7.4 5.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LRR_4 PF12799.2 ESS70234.1 - 5.5e-15 54.5 7.4 0.00016 21.1 0.0 5.6 4 1 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70234.1 - 3.4e-10 39.5 13.2 0.00029 20.5 0.3 4.6 3 2 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 ESS70234.1 - 2.5e-09 35.8 8.7 0.37 10.9 0.0 8.0 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS70234.1 - 2.3e-06 27.1 4.5 48 4.4 0.1 7.4 8 0 0 8 8 8 0 Leucine Rich repeat LRR_7 PF13504.1 ESS70234.1 - 5.9e-06 25.6 16.5 0.023 14.8 0.1 7.8 9 0 0 9 9 9 1 Leucine rich repeat LRR_9 PF14580.1 ESS70234.1 - 0.007 15.9 0.8 0.27 10.7 0.0 3.0 2 2 1 3 3 3 1 Leucine-rich repeat LRR_6 PF13516.1 ESS70235.1 - 4e-07 29.4 2.2 0.46 10.7 0.1 4.6 5 0 0 5 5 5 3 Leucine Rich repeat LRR_7 PF13504.1 ESS70235.1 - 0.004 17.1 5.0 69 4.3 0.0 5.9 6 0 0 6 6 6 1 Leucine rich repeat Phage_integrase PF00589.17 ESS70238.1 - 0.01 15.5 0.1 0.034 13.8 0.0 1.9 2 0 0 2 2 2 0 Phage integrase family BCDHK_Adom3 PF10436.4 ESS70240.1 - 6.4e-36 123.3 0.1 9.9e-36 122.7 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESS70240.1 - 8.3e-17 60.9 0.0 3.2e-15 55.7 0.0 2.9 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESS70240.1 - 8.3e-05 22.2 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Enkurin PF13864.1 ESS70241.1 - 5.9e-24 84.1 10.2 9.5e-24 83.4 7.1 1.3 1 0 0 1 1 1 1 Calmodulin-binding Carbpep_Y_N PF05388.6 ESS70241.1 - 0.1 12.7 0.5 0.18 11.9 0.3 1.4 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide AAA_5 PF07728.9 ESS70242.1 - 2.7e-130 428.9 0.0 8.1e-26 90.4 0.0 7.6 7 0 0 7 7 7 7 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESS70242.1 - 5.7e-30 103.6 0.0 5.2e-08 32.5 0.0 7.2 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 ESS70242.1 - 7.2e-23 81.2 0.0 0.0011 19.2 0.0 7.0 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESS70242.1 - 8.8e-22 77.6 0.0 0.012 15.7 0.0 7.5 7 0 0 7 7 6 5 AAA domain AAA_14 PF13173.1 ESS70242.1 - 2.7e-21 75.7 0.0 0.0011 18.9 0.0 6.7 6 0 0 6 6 6 4 AAA domain AAA_16 PF13191.1 ESS70242.1 - 1.3e-19 70.8 16.2 0.00042 20.3 0.0 8.7 9 0 0 9 9 7 4 AAA ATPase domain Sigma54_activ_2 PF14532.1 ESS70242.1 - 6e-19 68.4 0.6 0.00021 21.3 0.0 7.9 8 0 0 8 8 8 3 Sigma-54 interaction domain AAA_17 PF13207.1 ESS70242.1 - 4.9e-16 59.6 10.2 0.04 14.7 0.0 8.3 8 0 0 8 8 6 4 AAA domain Sigma54_activat PF00158.21 ESS70242.1 - 1.5e-15 57.0 0.0 0.01 15.2 0.0 6.7 6 1 0 6 6 6 3 Sigma-54 interaction domain ABC_tran PF00005.22 ESS70242.1 - 3.1e-13 50.1 5.7 0.043 14.1 0.0 7.4 7 0 0 7 7 6 2 ABC transporter AAA_18 PF13238.1 ESS70242.1 - 7.6e-13 48.8 2.2 0.076 13.3 0.0 7.6 7 0 0 7 7 6 2 AAA domain Zeta_toxin PF06414.7 ESS70242.1 - 9.2e-13 47.7 0.0 0.032 13.3 0.0 6.2 6 0 0 6 6 6 3 Zeta toxin IstB_IS21 PF01695.12 ESS70242.1 - 1e-12 47.8 0.1 0.015 14.7 0.0 5.2 5 0 0 5 5 5 3 IstB-like ATP binding protein AAA_33 PF13671.1 ESS70242.1 - 1.2e-12 47.9 0.0 0.13 12.1 0.0 6.8 7 0 0 7 7 6 3 AAA domain AAA_29 PF13555.1 ESS70242.1 - 4.1e-12 45.4 0.2 2.2 7.8 0.0 6.5 6 0 0 6 6 6 2 P-loop containing region of AAA domain UPF0079 PF02367.12 ESS70242.1 - 1.7e-11 43.7 3.1 0.046 13.3 0.1 6.4 6 0 0 6 6 6 2 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 ESS70242.1 - 1.9e-11 43.5 0.2 2.5 7.2 0.0 8.0 8 0 0 8 8 8 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 ESS70242.1 - 2e-11 43.4 2.1 0.62 9.8 0.0 6.6 6 0 0 6 6 6 2 Part of AAA domain T2SE PF00437.15 ESS70242.1 - 2.2e-11 43.2 0.1 0.11 11.3 0.0 6.1 6 0 0 6 6 6 3 Type II/IV secretion system protein DUF258 PF03193.11 ESS70242.1 - 4.4e-10 38.9 0.9 0.56 9.3 0.0 5.6 5 0 0 5 5 5 3 Protein of unknown function, DUF258 RNA_helicase PF00910.17 ESS70242.1 - 2.1e-09 37.5 0.7 0.25 11.5 0.0 6.5 7 0 0 7 7 6 1 RNA helicase NACHT PF05729.7 ESS70242.1 - 5.6e-07 29.3 3.0 1 8.9 0.0 6.0 6 0 0 6 6 6 2 NACHT domain AAA_25 PF13481.1 ESS70242.1 - 1.5e-06 27.7 0.1 8 5.8 0.0 6.3 7 0 0 7 7 6 0 AAA domain DUF815 PF05673.8 ESS70242.1 - 1.7e-06 27.1 4.2 1.2 8.0 0.0 5.5 7 0 0 7 7 6 2 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESS70242.1 - 1.7e-05 24.0 0.2 0.55 9.2 0.0 5.0 5 0 0 5 5 5 1 Holliday junction DNA helicase ruvB N-terminus PhoH PF02562.11 ESS70242.1 - 8.2e-05 21.9 0.4 5 6.2 0.0 5.0 5 0 0 5 5 5 0 PhoH-like protein CPT PF07931.7 ESS70242.1 - 0.00031 20.4 0.6 5 6.7 0.0 4.9 5 0 0 5 5 4 0 Chloramphenicol phosphotransferase-like protein Miro PF08477.8 ESS70242.1 - 0.00032 21.1 0.1 15 6.0 0.0 4.9 5 0 0 5 5 3 0 Miro-like protein AAA_10 PF12846.2 ESS70242.1 - 0.00056 19.4 0.2 12 5.2 0.0 4.2 4 0 0 4 4 3 0 AAA-like domain NTPase_1 PF03266.10 ESS70242.1 - 0.00098 18.8 4.6 2.3 7.8 0.0 5.0 6 0 0 6 6 6 2 NTPase MMR_HSR1 PF01926.18 ESS70242.1 - 0.0013 18.6 0.0 49 3.9 0.0 4.7 4 0 0 4 4 4 0 50S ribosome-binding GTPase Rad17 PF03215.10 ESS70242.1 - 0.002 16.9 0.0 8.6 4.9 0.0 4.3 5 0 0 5 5 5 0 Rad17 cell cycle checkpoint protein TIP49 PF06068.8 ESS70242.1 - 0.0026 16.5 1.2 3.5 6.2 0.0 4.0 5 0 0 5 5 4 1 TIP49 C-terminus KaiC PF06745.8 ESS70242.1 - 0.0039 16.3 0.3 11 5.0 0.0 4.6 5 0 0 5 5 5 0 KaiC DEAD PF00270.24 ESS70242.1 - 0.0054 16.2 0.0 4.1 6.8 0.0 4.5 4 0 0 4 4 4 0 DEAD/DEAH box helicase ArgK PF03308.11 ESS70242.1 - 0.0063 15.3 0.3 0.62 8.7 0.0 2.6 2 0 0 2 2 2 1 ArgK protein PduV-EutP PF10662.4 ESS70242.1 - 0.013 14.9 1.9 33 3.9 0.0 5.1 6 0 0 6 6 6 0 Ethanolamine utilisation - propanediol utilisation AAA_6 PF12774.2 ESS70242.1 - 0.13 11.7 0.0 1e+02 2.3 0.0 4.0 4 0 0 4 4 4 0 Hydrolytic ATP binding site of dynein motor region D1 DS PF01916.12 ESS70243.1 - 1.8e-74 250.5 0.0 2.6e-73 246.7 0.0 1.9 1 1 0 1 1 1 1 Deoxyhypusine synthase Kelch_6 PF13964.1 ESS70246.1 - 3.5e-30 102.9 24.2 1.8e-05 24.6 0.2 6.2 5 1 1 6 6 6 6 Kelch motif Kelch_5 PF13854.1 ESS70246.1 - 1.4e-25 88.8 26.8 2.1e-08 33.9 0.2 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 ESS70246.1 - 7.9e-21 73.6 18.2 0.00021 21.3 0.0 7.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.1 ESS70246.1 - 1.5e-19 69.4 19.3 7.3e-05 22.4 0.3 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESS70246.1 - 4.8e-18 64.1 20.6 2.3e-05 23.9 0.1 7.0 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ESS70246.1 - 1.9e-17 62.5 28.7 6.6e-05 22.3 0.1 7.1 6 2 0 6 6 6 5 Kelch motif PQQ_3 PF13570.1 ESS70246.1 - 2.7 8.3 8.4 15 6.0 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain LRR_4 PF12799.2 ESS70249.1 - 0.004 16.7 0.0 0.67 9.6 0.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) Reg_prop PF07494.6 ESS70250.1 - 0.064 13.2 0.1 13 6.2 0.0 2.9 2 0 0 2 2 2 0 Two component regulator propeller PQQ_3 PF13570.1 ESS70250.1 - 0.075 13.3 0.5 0.76 10.1 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain DUF1098 PF06497.6 ESS70250.1 - 0.23 11.5 0.0 0.44 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1098) CTNNBL PF08216.6 ESS70251.1 - 0.0049 16.4 4.4 0.47 10.0 0.4 2.4 1 1 1 2 2 2 2 Catenin-beta-like, Arm-motif containing nuclear ERM PF00769.14 ESS70251.1 - 0.015 14.8 20.2 0.023 14.2 14.0 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF1664 PF07889.7 ESS70251.1 - 0.024 14.4 5.2 0.16 11.7 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.7 ESS70251.1 - 0.067 12.3 3.5 0.11 11.7 2.2 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Occludin_ELL PF07303.8 ESS70251.1 - 0.1 13.3 14.9 0.34 11.6 5.7 2.8 1 1 2 3 3 3 0 Occludin homology domain DUF948 PF06103.6 ESS70251.1 - 0.11 12.3 3.7 0.29 11.0 0.3 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GAS PF13851.1 ESS70251.1 - 0.21 10.7 20.5 0.72 9.0 14.2 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding FYVE_2 PF02318.11 ESS70251.1 - 0.23 11.3 7.5 1.9 8.3 0.1 3.0 1 1 1 3 3 3 0 FYVE-type zinc finger V_ATPase_I PF01496.14 ESS70251.1 - 0.31 8.8 9.6 0.36 8.6 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fmp27_WPPW PF10359.4 ESS70251.1 - 0.34 9.2 10.6 0.49 8.7 7.0 1.4 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Mnd1 PF03962.10 ESS70251.1 - 0.41 10.2 18.6 0.017 14.7 2.9 2.0 1 1 1 2 2 2 0 Mnd1 family DUF342 PF03961.8 ESS70251.1 - 1.5 7.1 6.4 1.7 6.9 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Laminin_II PF06009.7 ESS70251.1 - 2.2 8.0 8.9 3.2 7.4 4.4 2.1 1 1 0 1 1 1 0 Laminin Domain II LMBR1 PF04791.11 ESS70251.1 - 2.6 6.5 7.7 3 6.3 5.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-H PF05837.7 ESS70251.1 - 3.7 7.7 16.0 1.4 9.1 2.5 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF904 PF06005.7 ESS70251.1 - 6.9 7.0 19.6 0.041 14.1 4.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF904) MORN PF02493.15 ESS70253.1 - 2.1e-10 39.6 14.4 2.1e-05 23.9 0.0 6.1 6 0 0 6 6 6 3 MORN repeat Filament PF00038.16 ESS70253.1 - 0.057 12.8 4.5 0.08 12.3 3.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein Kelch_5 PF13854.1 ESS70254.1 - 3.7e-23 81.0 15.6 1.1e-05 25.2 0.3 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 ESS70254.1 - 1.4e-20 72.8 21.0 5.8e-06 26.3 0.5 8.0 7 1 1 8 8 8 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESS70254.1 - 2.4e-18 65.4 5.7 0.0001 21.7 0.0 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESS70254.1 - 1.5e-17 62.9 11.0 0.011 15.8 0.2 6.6 5 1 2 7 7 7 5 Kelch motif Kelch_4 PF13418.1 ESS70254.1 - 8.4e-15 54.2 18.6 0.00026 20.6 0.3 7.0 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESS70254.1 - 7.8e-12 44.4 12.1 0.037 13.7 0.0 6.2 6 0 0 6 6 6 4 Kelch motif AAA_16 PF13191.1 ESS70255.1 - 0.00021 21.3 1.6 0.00041 20.4 0.0 2.1 2 1 1 3 3 3 1 AAA ATPase domain NACHT PF05729.7 ESS70255.1 - 0.00047 19.8 0.1 1.5 8.4 0.0 3.2 3 1 0 4 4 4 2 NACHT domain AAA_14 PF13173.1 ESS70255.1 - 0.0015 18.4 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.17 ESS70255.1 - 0.013 14.3 0.0 0.033 13.0 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain AAA PF00004.24 ESS70255.1 - 0.054 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 ESS70255.1 - 0.094 12.4 0.0 0.23 11.1 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase DUF258 PF03193.11 ESS70255.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESS70255.1 - 0.13 12.4 0.0 0.69 10.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain PGK PF00162.14 ESS70256.1 - 2.2e-05 23.2 0.0 2.6e-05 22.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase EIIC-GAT PF03611.9 ESS70256.1 - 0.061 12.0 0.0 0.07 11.8 0.0 1.0 1 0 0 1 1 1 0 PTS system sugar-specific permease component BRCA-2_OB1 PF09103.5 ESS70259.1 - 4.7e-32 110.1 0.0 8.9e-32 109.2 0.0 1.5 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA2 PF00634.13 ESS70259.1 - 1.7e-06 27.1 2.5 0.04 13.2 0.0 2.8 3 0 0 3 3 3 2 BRCA2 repeat Peptidase_M9_N PF08453.5 ESS70259.1 - 0.12 11.7 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 Peptidase family M9 N-terminal PHO4 PF01384.15 ESS70261.1 - 2.3e-85 286.1 16.9 2.6e-85 285.9 11.7 1.0 1 0 0 1 1 1 1 Phosphate transporter family DOT1 PF08123.8 ESS70262.1 - 7.1e-23 80.9 0.0 9.2e-23 80.6 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 ESS70262.1 - 6.1e-07 29.9 0.0 9.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS70262.1 - 1.1e-05 25.0 0.0 1.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS70262.1 - 3e-05 24.0 0.0 5.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS70262.1 - 0.00034 20.9 0.0 0.00074 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS70262.1 - 0.00039 20.8 0.0 0.00076 19.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESS70262.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.8 ESS70262.1 - 0.064 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase CMAS PF02353.15 ESS70262.1 - 0.065 12.3 0.0 0.098 11.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 ESS70262.1 - 0.085 12.5 0.0 0.19 11.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESS70262.1 - 0.11 13.0 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 ESS70262.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.12 ESS70262.1 - 0.16 10.9 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase WD40 PF00400.27 ESS70263.1 - 2.4e-16 58.8 4.3 1.3e-07 31.2 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.1 ESS70263.1 - 0.027 14.7 0.0 1.7 8.9 0.0 2.6 2 0 0 2 2 2 0 PQQ-like domain PQQ_2 PF13360.1 ESS70263.1 - 0.034 13.5 0.0 2.9 7.2 0.0 2.2 1 1 1 2 2 2 0 PQQ-like domain DUF3312 PF11768.3 ESS70263.1 - 0.078 11.1 0.1 0.2 9.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) VPS9 PF02204.13 ESS70264.1 - 0.00016 21.6 0.3 0.00046 20.1 0.1 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RNA_pol_Rpb2_6 PF00562.23 ESS70265.1 - 1.6e-113 379.4 0.0 2.2e-113 378.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 ESS70265.1 - 1.7e-45 154.4 0.3 2.6e-45 153.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 ESS70265.1 - 3.2e-28 97.7 0.0 8.2e-28 96.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.9 ESS70265.1 - 1.8e-20 73.1 0.5 3.8e-20 72.1 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.8 ESS70265.1 - 9.9e-19 66.9 1.7 2.7e-18 65.5 1.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 ESS70265.1 - 6.4e-18 64.2 0.0 1.3e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 ESS70265.1 - 1.5e-09 37.6 0.3 3.8e-09 36.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 ASF1_hist_chap PF04729.8 ESS70268.1 - 1.2e-50 171.0 0.0 1.5e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Tymo_coat PF00983.13 ESS70268.1 - 0.039 13.6 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 Tymovirus coat protein HTH_27 PF13463.1 ESS70269.1 - 0.0095 16.2 0.1 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain PGK PF00162.14 ESS70270.1 - 1.1e-145 485.0 0.0 2.6e-145 483.8 0.0 1.5 1 1 0 1 1 1 1 Phosphoglycerate kinase MFS_1 PF07690.11 ESS70297.1 - 2e-09 36.6 31.4 3.2e-06 26.1 15.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESS70297.1 - 2.8e-06 26.8 10.0 2.8e-06 26.8 6.9 2.6 2 1 0 2 2 2 1 Nodulin-like DnaJ PF00226.26 ESS70300.1 - 1.7e-09 37.3 0.0 9.3e-09 34.9 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain SSXT PF05030.7 ESS70300.1 - 0.011 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 SSXT protein (N-terminal region) DUF1279 PF06916.8 ESS70300.1 - 0.05 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) WASH-7_N PF14745.1 ESS70301.1 - 2e-190 633.7 2.0 2e-190 633.7 1.4 2.1 2 0 0 2 2 2 1 WASH complex subunit 7, N-terminal WASH-7_mid PF14744.1 ESS70301.1 - 1.8e-150 500.6 1.2 3e-150 499.9 0.8 1.3 1 0 0 1 1 1 1 WASH complex subunit 7 WASH-7_C PF14746.1 ESS70301.1 - 1e-61 207.4 1.3 3.2e-61 205.8 0.9 1.9 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Tet_res_leader PF08050.7 ESS70301.1 - 0.083 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Tetracycline resistance leader peptide Fzo_mitofusin PF04799.8 ESS70302.1 - 0.0013 18.0 2.2 0.002 17.5 1.5 1.1 1 0 0 1 1 1 1 fzo-like conserved region CENP-F_leu_zip PF10473.4 ESS70302.1 - 0.0088 15.8 4.8 0.013 15.3 3.3 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OmpH PF03938.9 ESS70302.1 - 0.023 14.6 2.3 0.036 14.0 1.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1780 PF08682.5 ESS70302.1 - 0.091 12.2 1.2 0.15 11.4 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1780) Rubella_Capsid PF05750.6 ESS70302.1 - 0.67 9.2 12.8 0.83 8.9 7.0 2.3 2 1 0 2 2 2 0 Rubella capsid protein Nucleoporin_C PF03177.9 ESS70303.1 - 0.0041 15.7 0.1 0.0057 15.2 0.1 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal PHD PF00628.24 ESS70304.1 - 5.2e-07 29.2 7.7 1.4e-06 27.9 5.3 1.8 1 0 0 1 1 1 1 PHD-finger Acetyltransf_1 PF00583.19 ESS70304.1 - 9.3e-05 22.3 0.1 0.00082 19.3 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESS70304.1 - 0.00024 21.1 0.3 0.0095 16.0 0.1 3.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESS70304.1 - 0.00085 19.4 0.0 0.0027 17.8 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESS70304.1 - 0.027 14.3 0.9 1.6 8.5 0.5 3.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Glyco_transf_8 PF01501.15 ESS70305.1 - 4.4e-12 45.8 0.0 7.1e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_18 PF15024.1 ESS70305.1 - 1.6e-05 23.5 0.4 2.2e-05 23.0 0.3 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 DUF1193 PF06702.7 ESS70305.1 - 0.00066 19.1 0.8 0.01 15.2 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1193) PI3_PI4_kinase PF00454.22 ESS70305.1 - 0.014 14.8 0.1 0.024 14.0 0.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase Pkinase PF00069.20 ESS70306.1 - 3.8e-20 72.1 0.0 5e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70306.1 - 8.2e-11 41.4 0.0 1.1e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESS70306.1 - 0.00015 20.8 0.0 0.00021 20.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESS70306.1 - 0.00038 19.5 0.1 0.00071 18.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESS70306.1 - 0.0078 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESS70306.1 - 0.01 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RRM_1 PF00076.17 ESS70307.1 - 0.032 13.8 0.0 0.074 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ste5_C PF12194.3 ESS70307.1 - 0.075 12.6 0.0 3.7 7.1 0.0 2.1 2 0 0 2 2 2 0 Protein kinase Fus3-binding RRM_6 PF14259.1 ESS70307.1 - 0.13 12.2 0.1 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SUI1 PF01253.17 ESS70308.1 - 4.9e-23 80.7 0.2 4.9e-23 80.7 0.2 1.7 2 0 0 2 2 2 1 Translation initiation factor SUI1 RIP PF00161.14 ESS70308.1 - 0.0029 16.8 0.5 0.0044 16.2 0.4 1.3 1 0 0 1 1 1 1 Ribosome inactivating protein DUF1995 PF09353.5 ESS70308.1 - 0.085 12.4 0.1 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1995) YL1 PF05764.8 ESS70309.1 - 2.5e-08 33.8 6.6 3.4e-08 33.3 4.6 1.2 1 0 0 1 1 1 1 YL1 nuclear protein Bax1-I PF01027.15 ESS70310.1 - 7.4e-37 126.9 18.9 7.4e-37 126.9 13.1 1.5 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Galactosyl_T PF01762.16 ESS70311.1 - 1.2e-08 34.8 0.2 0.0011 18.5 0.1 2.7 2 1 0 2 2 2 2 Galactosyltransferase ESX-1_EspG PF14011.1 ESS70311.1 - 0.092 11.9 1.0 0.7 9.0 0.2 2.1 1 1 1 2 2 2 0 EspG family Adaptin_binding PF10199.4 ESS70312.1 - 6e-06 26.5 4.6 0.74 10.0 0.0 3.9 3 1 0 3 3 3 3 Alpha and gamma adaptin binding protein p34 TSC22 PF01166.13 ESS70314.1 - 0.082 12.8 0.3 0.082 12.8 0.2 5.8 6 1 1 7 7 7 0 TSC-22/dip/bun family Shugoshin_N PF07558.6 ESS70314.1 - 0.47 10.2 5.4 0.39 10.4 1.4 2.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region RNA_pol PF00940.14 ESS70315.1 - 1.8e-125 418.6 0.0 2.5e-125 418.1 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase fn3 PF00041.16 ESS70316.1 - 2.1e-14 53.3 0.2 6.7e-06 26.1 0.0 5.6 5 1 0 5 5 5 3 Fibronectin type III domain EF-hand_1 PF00036.27 ESS70319.1 - 0.0039 16.3 0.0 0.4 10.1 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 ESS70319.1 - 0.0048 16.6 0.0 0.31 11.0 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 ESS70319.1 - 0.0057 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS70319.1 - 0.076 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair PH PF00169.24 ESS70320.1 - 0.066 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 PH domain TMF_DNA_bd PF12329.3 ESS70321.1 - 5.9e-06 26.0 4.7 5.9e-06 26.0 3.2 8.0 8 2 1 9 9 9 2 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.3 ESS70321.1 - 0.0011 18.6 0.4 0.0011 18.6 0.3 7.7 6 2 1 7 7 7 1 TATA element modulatory factor 1 TATA binding DUF2353 PF09789.4 ESS70321.1 - 0.0015 17.8 1.3 0.0015 17.8 0.9 5.0 2 2 2 4 4 4 1 Uncharacterized coiled-coil protein (DUF2353) CENP-F_leu_zip PF10473.4 ESS70321.1 - 0.0079 16.0 1.8 0.0079 16.0 1.3 7.9 6 2 1 7 7 7 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OEP PF02321.13 ESS70321.1 - 0.037 13.6 0.0 0.037 13.6 0.0 4.9 4 1 1 5 5 4 0 Outer membrane efflux protein NPV_P10 PF05531.7 ESS70321.1 - 0.15 12.3 5.0 0.93 9.7 0.2 4.3 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 ESS70321.1 - 0.16 11.0 10.5 1.1 8.4 0.7 4.0 4 1 2 6 6 6 0 Reovirus sigma C capsid protein Atg14 PF10186.4 ESS70321.1 - 0.17 10.7 47.0 0.038 12.9 4.7 6.0 5 1 1 6 6 6 0 UV radiation resistance protein and autophagy-related subunit 14 Fib_alpha PF08702.5 ESS70321.1 - 2.2 8.4 29.2 2.9 7.9 0.3 6.6 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family Gp58 PF07902.6 ESS70321.1 - 3.2 5.8 8.1 2.2 6.4 4.2 1.7 1 1 0 2 2 2 0 gp58-like protein Bacillus_HBL PF05791.6 ESS70321.1 - 7.2 5.9 12.5 1.4 8.2 0.1 4.7 5 0 0 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) FH2 PF02181.18 ESS70322.1 - 1.4e-50 172.2 0.7 1.9e-50 171.7 0.5 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain SRPRB PF09439.5 ESS70322.1 - 0.12 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF2360 PF10152.4 ESS70322.1 - 4.8 7.4 11.8 4.8 7.4 4.8 2.8 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) OB_NTP_bind PF07717.11 ESS70323.1 - 7.6e-15 54.7 0.0 2e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESS70323.1 - 1.5e-14 53.8 0.0 2.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESS70323.1 - 2.1e-10 40.2 0.0 8.4e-10 38.3 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS70323.1 - 3.8e-07 29.7 0.0 7.5e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESS70323.1 - 0.0002 21.5 0.2 0.00062 19.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS70323.1 - 0.0091 15.7 1.6 0.023 14.4 0.1 2.3 2 0 0 2 2 2 1 Part of AAA domain Flavi_DEAD PF07652.9 ESS70323.1 - 0.031 14.0 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Zot PF05707.7 ESS70323.1 - 0.077 12.4 0.1 0.22 10.9 0.0 1.8 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_23 PF13476.1 ESS70323.1 - 0.093 13.0 1.5 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESS70323.1 - 0.14 12.0 0.4 2.8 7.8 0.3 2.3 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 ESS70323.1 - 0.18 11.6 0.0 20 4.9 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2229 PF09989.4 ESS70324.1 - 0.19 11.1 0.2 4.3 6.7 0.0 2.1 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) RhodobacterPufX PF11511.3 ESS70325.1 - 5.1 6.5 9.5 27 4.2 0.1 3.9 3 0 0 3 3 3 0 Intrinsic membrane protein PufX DnaJ PF00226.26 ESS70326.1 - 1.6e-15 56.5 0.0 3.9e-15 55.3 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain DUF2215 PF10225.4 ESS70326.1 - 0.018 14.5 0.8 1.9 7.8 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2215) TAN PF11640.3 ESS70326.1 - 0.11 12.2 0.2 0.21 11.3 0.2 1.4 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair TRAPPC10 PF12584.3 ESS70327.1 - 0.0059 16.1 0.0 0.015 14.8 0.0 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 SNF2_N PF00176.18 ESS70329.1 - 2.4e-42 144.7 0.1 4.6e-42 143.8 0.0 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS70329.1 - 2.8e-11 43.1 0.0 8e-11 41.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS70329.1 - 1.8e-06 27.8 0.0 1e-05 25.4 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Nucleoside_tran PF01733.13 ESS70331.1 - 4.1e-32 111.5 0.7 1.1e-31 110.1 0.5 1.6 1 1 0 1 1 1 1 Nucleoside transporter Vma12 PF11712.3 ESS70331.1 - 0.65 9.6 3.6 5.1 6.8 0.1 2.8 2 1 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Mnd1 PF03962.10 ESS70332.1 - 4.3e-64 215.6 0.2 1.6e-63 213.8 0.0 1.8 2 0 0 2 2 2 1 Mnd1 family TBPIP PF07106.8 ESS70332.1 - 0.00018 21.0 1.0 0.57 9.7 0.0 2.8 2 1 0 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ATG16 PF08614.6 ESS70332.1 - 0.033 14.0 2.8 0.061 13.1 0.0 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) ROS_MUCR PF05443.6 ESS70332.1 - 1.7 8.4 5.0 1.3 8.8 0.5 2.7 2 1 0 2 2 2 0 ROS/MUCR transcriptional regulator protein WW PF00397.21 ESS70333.1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 WW domain Cep57_CLD_2 PF14197.1 ESS70333.1 - 7.7 6.5 12.8 0.76 9.7 0.2 3.4 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 RFC1 PF08519.7 ESS70335.1 - 1.7e-49 167.5 0.0 1.2e-48 164.7 0.0 2.2 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain Rad17 PF03215.10 ESS70335.1 - 3.6e-14 52.3 0.2 4.9e-10 38.7 0.0 3.1 3 0 0 3 3 3 2 Rad17 cell cycle checkpoint protein AAA PF00004.24 ESS70335.1 - 2.9e-10 40.4 0.9 6.3e-10 39.3 0.0 2.1 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESS70335.1 - 7.7e-05 21.8 0.0 0.00017 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ESS70335.1 - 7.9e-05 22.8 1.8 0.00012 22.2 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESS70335.1 - 0.00027 21.0 0.0 0.00077 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 ESS70335.1 - 0.0017 18.2 0.0 0.0043 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS70335.1 - 0.0025 18.6 0.0 0.017 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS70335.1 - 0.004 16.8 0.0 0.0099 15.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 ESS70335.1 - 0.006 16.3 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 ESS70335.1 - 0.0063 16.6 0.0 0.023 14.8 0.0 2.0 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 ESS70335.1 - 0.041 14.1 0.0 0.13 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESS70335.1 - 0.041 13.4 0.5 0.19 11.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain DUF2036 PF09724.4 ESS70335.1 - 0.05 12.7 0.1 0.1 11.7 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2036) AAA_33 PF13671.1 ESS70335.1 - 0.053 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESS70335.1 - 0.09 12.4 0.1 0.2 11.3 0.0 1.6 1 1 0 1 1 1 0 NTPase Hormone_3 PF00159.13 ESS70337.1 - 0.027 14.4 1.0 3.2 7.8 0.0 2.8 2 0 0 2 2 2 0 Pancreatic hormone peptide RabGAP-TBC PF00566.13 ESS70340.1 - 6.6e-09 35.5 1.2 1.3e-08 34.5 0.5 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Apc4_WD40 PF12894.2 ESS70341.1 - 8.5e-05 21.9 0.6 0.12 11.9 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_11 PF08241.7 ESS70342.1 - 0.0013 19.1 0.0 0.0029 18.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS70342.1 - 0.002 17.5 0.1 0.0048 16.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESS70342.1 - 0.0067 16.7 0.2 0.051 13.9 0.1 2.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS70342.1 - 0.03 14.7 1.8 0.075 13.5 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_8 PF05148.10 ESS70342.1 - 0.032 13.8 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_23 PF13489.1 ESS70342.1 - 0.042 13.5 0.0 0.11 12.1 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESS70342.1 - 0.081 12.9 0.1 0.19 11.7 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ESS70342.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MCM PF00493.18 ESS70343.1 - 1.7e-120 401.8 0.0 2.7e-120 401.1 0.0 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESS70343.1 - 4.4e-14 52.9 0.0 1.5e-13 51.3 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESS70343.1 - 7.7e-07 28.4 0.0 7.6e-06 25.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESS70343.1 - 0.00056 19.6 0.2 0.0035 17.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESS70343.1 - 0.00073 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PUA PF01472.15 ESS70343.1 - 0.018 14.7 1.8 4.6 7.0 0.1 2.5 2 0 0 2 2 2 0 PUA domain tRNA_anti_2 PF13742.1 ESS70343.1 - 0.043 13.6 0.1 3.7 7.4 0.0 3.0 3 0 0 3 3 3 0 OB-fold nucleic acid binding domain Sigma54_activat PF00158.21 ESS70343.1 - 0.044 13.2 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain DNA_pol_A PF00476.15 ESS70345.1 - 7.8e-35 120.1 0.0 1.8e-34 118.9 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family A Mito_fiss_reg PF05308.6 ESS70345.1 - 0.16 11.3 2.4 0.43 9.8 1.6 1.7 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 ESS70345.1 - 0.44 9.7 4.3 1 8.6 3.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal EMP24_GP25L PF01105.19 ESS70346.1 - 2.4e-13 50.2 0.0 3.1e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TIM PF00121.13 ESS70348.1 - 9.1e-88 293.4 0.1 1.1e-87 293.2 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase AP_endonuc_2 PF01261.19 ESS70348.1 - 0.0071 15.6 0.1 0.011 15.0 0.1 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel CbiJ PF02571.9 ESS70348.1 - 0.056 12.7 0.4 1.4 8.2 0.0 2.1 1 1 1 2 2 2 0 Precorrin-6x reductase CbiJ/CobK Ax_dynein_light PF10211.4 ESS70349.1 - 1.3e-76 256.6 9.3 1.8e-76 256.2 6.4 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain ERM PF00769.14 ESS70349.1 - 0.0037 16.8 12.7 0.0046 16.5 7.8 1.8 2 0 0 2 2 2 1 Ezrin/radixin/moesin family APG6 PF04111.7 ESS70349.1 - 0.0042 16.1 5.5 0.0073 15.3 3.8 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 Syntaxin-6_N PF09177.6 ESS70349.1 - 0.0042 17.4 2.5 0.011 16.1 1.7 1.8 1 0 0 1 1 1 1 Syntaxin 6, N-terminal DUF3373 PF11853.3 ESS70349.1 - 0.0084 14.6 0.8 0.012 14.2 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3373) Spc24 PF08286.6 ESS70349.1 - 0.011 15.4 4.6 0.023 14.4 3.2 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Spc7 PF08317.6 ESS70349.1 - 0.026 13.1 2.8 0.035 12.7 2.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TBPIP PF07106.8 ESS70349.1 - 0.042 13.3 2.3 0.088 12.3 1.6 1.5 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.9 ESS70349.1 - 0.046 13.3 16.3 0.018 14.6 7.4 2.0 1 1 0 2 2 2 0 IncA protein DUF342 PF03961.8 ESS70349.1 - 0.12 10.8 2.2 0.18 10.1 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) OmpH PF03938.9 ESS70349.1 - 0.25 11.2 13.8 0.7 9.8 9.6 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.10 ESS70349.1 - 0.27 10.8 9.2 0.58 9.7 6.3 1.5 1 0 0 1 1 1 0 Mnd1 family DivIC PF04977.10 ESS70349.1 - 0.47 9.9 8.3 0.31 10.5 3.5 2.2 2 0 0 2 2 2 0 Septum formation initiator L_lactis_ph-MCP PF06673.6 ESS70349.1 - 0.65 8.7 3.6 0.95 8.1 2.5 1.2 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein Nsp1_C PF05064.8 ESS70349.1 - 0.91 9.1 5.0 2.1 8.0 3.2 1.8 1 1 0 1 1 1 0 Nsp1-like C-terminal region FUSC PF04632.7 ESS70349.1 - 0.98 7.7 7.7 1.2 7.4 5.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4337 PF14235.1 ESS70349.1 - 1.2 8.9 6.3 2.1 8.1 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Atg14 PF10186.4 ESS70349.1 - 2 7.2 8.3 1.5 7.6 4.8 1.5 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4164 PF13747.1 ESS70349.1 - 5.5 7.1 15.9 4.4 7.4 6.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) HALZ PF02183.13 ESS70349.1 - 7.6 6.3 10.5 0.58 9.9 0.9 3.5 3 1 0 3 3 3 0 Homeobox associated leucine zipper Ax_dynein_light PF10211.4 ESS70350.1 - 2.3e-36 125.3 0.2 3.8e-36 124.7 0.1 1.3 1 0 0 1 1 1 1 Axonemal dynein light chain Syja_N PF02383.13 ESS70352.1 - 4.9e-66 222.6 0.0 7.2e-66 222.1 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF547 PF04784.9 ESS70352.1 - 2.1e-12 46.9 0.0 5.4e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF547 PTS_2-RNA PF01885.11 ESS70353.1 - 3.8e-56 189.3 0.0 6.4e-56 188.6 0.0 1.3 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family RNase_T PF00929.19 ESS70353.1 - 3.9e-17 63.0 0.0 7.8e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Exonuclease Malic_M PF03949.10 ESS70355.1 - 4e-79 265.7 0.1 5.1e-79 265.4 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 ESS70355.1 - 3.6e-71 238.5 0.0 5.7e-71 237.8 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.10 ESS70356.1 - 1e-77 261.1 0.1 1.4e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 ESS70356.1 - 1.1e-64 217.3 0.0 2.2e-64 216.4 0.0 1.5 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain COG5 PF10392.4 ESS70356.1 - 0.27 11.1 0.8 0.76 9.7 0.1 2.0 2 0 0 2 2 2 0 Golgi transport complex subunit 5 SNF2_N PF00176.18 ESS70357.1 - 9.5e-61 205.1 0.0 1.7e-60 204.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS70357.1 - 2.1e-16 59.5 0.0 4.7e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESS70357.1 - 1.6e-11 44.0 0.0 3.5e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS70357.1 - 0.00017 21.4 0.1 0.00047 20.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RNA_pol_3_Rpc31 PF11705.3 ESS70357.1 - 7.5 6.4 18.6 3.9 7.3 11.1 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 MscS_porin PF12795.2 ESS70358.1 - 0.00029 20.2 4.1 0.012 14.8 4.2 2.0 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain GAS PF13851.1 ESS70358.1 - 0.0058 15.8 14.2 0.0083 15.3 9.8 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Myosin_tail_1 PF01576.14 ESS70358.1 - 0.01 13.6 16.8 0.014 13.1 11.6 1.1 1 0 0 1 1 1 1 Myosin tail OmpH PF03938.9 ESS70358.1 - 0.18 11.7 6.3 0.3 11.0 4.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_MLP1_2 PF07926.7 ESS70358.1 - 0.55 9.9 16.8 0.041 13.6 3.1 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Striatin PF08232.7 ESS70358.1 - 0.62 10.3 16.5 3.2 8.0 5.3 2.5 1 1 1 2 2 2 0 Striatin family V_ATPase_I PF01496.14 ESS70358.1 - 0.62 7.8 4.0 0.99 7.1 2.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Macoilin PF09726.4 ESS70358.1 - 1.5 7.0 15.5 0.068 11.4 1.4 2.2 1 1 1 2 2 2 0 Transmembrane protein Syntaxin_2 PF14523.1 ESS70358.1 - 5.8 7.0 11.8 1.6 8.7 2.5 2.3 1 1 1 2 2 2 0 Syntaxin-like protein DUF904 PF06005.7 ESS70358.1 - 6.8 7.0 13.2 2.4 8.5 3.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF904) TMF_TATA_bd PF12325.3 ESS70358.1 - 7.4 6.3 14.6 6.2 6.5 7.5 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3847 PF12958.2 ESS70358.1 - 7.9 6.3 17.4 1.1 9.1 2.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) SRP54 PF00448.17 ESS70361.1 - 3.5e-74 248.4 0.5 6.7e-74 247.5 0.4 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 ESS70361.1 - 3.6e-26 91.4 0.3 3.6e-26 91.4 0.2 3.9 3 1 2 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.14 ESS70361.1 - 9.6e-14 51.2 0.9 2.5e-13 49.9 0.2 2.1 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 ESS70361.1 - 1e-07 31.6 0.2 3.3e-07 29.9 0.1 1.9 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.18 ESS70361.1 - 2.1e-06 27.2 0.1 7.9e-06 25.4 0.1 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.1 ESS70361.1 - 4.6e-06 26.5 0.0 1.3e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ESS70361.1 - 3e-05 23.7 0.3 0.00039 20.1 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 ESS70361.1 - 0.00015 20.6 0.5 0.0071 15.1 0.0 3.0 2 1 1 3 3 3 1 ArgK protein AAA_22 PF13401.1 ESS70361.1 - 0.00017 21.7 0.2 0.0017 18.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESS70361.1 - 0.0013 17.8 0.0 0.0029 16.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_31 PF13614.1 ESS70361.1 - 0.0015 18.5 0.0 2.1 8.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESS70361.1 - 0.003 17.5 0.0 0.0067 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain Methyltransf_24 PF13578.1 ESS70361.1 - 0.0041 17.9 0.0 0.011 16.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain AAA_30 PF13604.1 ESS70361.1 - 0.007 15.9 0.1 0.025 14.1 0.1 2.0 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.15 ESS70361.1 - 0.0077 15.8 0.0 0.019 14.5 0.0 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_25 PF13481.1 ESS70361.1 - 0.0092 15.4 0.0 0.033 13.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS70361.1 - 0.0098 16.7 0.0 0.02 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESS70361.1 - 0.015 14.5 0.7 4.1 6.5 0.1 2.4 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 ESS70361.1 - 0.019 14.5 0.4 0.11 12.0 0.3 2.4 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 ESS70361.1 - 0.021 15.1 0.7 5.2 7.3 0.0 2.8 3 0 0 3 3 3 0 ABC transporter KaiC PF06745.8 ESS70361.1 - 0.034 13.2 0.3 0.14 11.2 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA PF00004.24 ESS70361.1 - 0.078 13.1 0.2 0.37 11.0 0.2 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3670 PF12419.3 ESS70361.1 - 0.091 12.1 0.1 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 SNF2 Helicase protein AAA_19 PF13245.1 ESS70361.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain NTPase_1 PF03266.10 ESS70361.1 - 1.9 8.1 7.4 16 5.1 1.7 3.1 2 1 0 2 2 2 0 NTPase DUF523 PF04463.7 ESS70362.1 - 1.4e-15 57.2 0.0 1.4e-14 54.0 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF523) UPF0118 PF01594.11 ESS70363.1 - 0.00033 19.7 8.1 0.0043 16.1 2.2 4.1 4 0 0 4 4 4 3 Domain of unknown function DUF20 Aldo_ket_red PF00248.16 ESS70364.1 - 1.9e-39 135.2 0.0 2.4e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Kelch_3 PF13415.1 ESS70365.1 - 1.4e-28 98.3 14.4 1.6e-06 28.1 0.0 7.4 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.1 ESS70365.1 - 1.9e-27 94.7 11.5 2.8e-05 23.9 0.2 6.2 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESS70365.1 - 1.1e-24 85.8 9.2 9e-05 22.1 0.0 6.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESS70365.1 - 2.5e-19 68.2 3.3 0.00031 20.3 0.0 5.8 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.1 ESS70365.1 - 1.4e-11 44.0 3.5 0.16 12.1 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESS70365.1 - 2.3e-11 43.0 4.6 4.6e-06 26.0 0.0 6.0 6 0 0 6 6 6 1 Kelch motif RAG2 PF03089.9 ESS70365.1 - 0.00012 20.9 0.5 0.31 9.7 0.0 3.9 4 0 0 4 4 4 2 Recombination activating protein 2 DX PF01666.12 ESS70365.1 - 0.097 13.1 2.7 1.7 9.1 0.3 2.6 2 0 0 2 2 2 0 DX module Sugar_tr PF00083.19 ESS70366.1 - 1.6e-109 366.5 33.4 1.8e-109 366.3 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESS70366.1 - 4.5e-30 104.5 33.5 4.5e-30 104.5 23.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 ESS70366.1 - 0.0011 17.5 5.6 0.0011 17.5 3.9 3.9 2 2 1 4 4 4 2 MFS/sugar transport protein Pex14_N PF04695.8 ESS70366.1 - 0.0026 17.8 1.1 0.0031 17.5 0.1 1.6 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.20 ESS70367.1 - 5.4e-42 143.7 0.0 1.7e-41 142.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70367.1 - 2.8e-13 49.5 0.0 1.1e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESS70367.1 - 0.0002 20.4 0.0 0.00032 19.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESS70367.1 - 0.084 11.8 0.0 1.5 7.7 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Peptidase_C97 PF05903.9 ESS70369.1 - 6.2e-25 87.7 0.2 1.2e-24 86.8 0.2 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 ESS70369.1 - 0.0013 18.6 0.1 0.0049 16.8 0.0 2.0 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Kinesin PF00225.18 ESS70371.1 - 4e-89 298.6 0.1 6.9e-89 297.8 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Mito_carr PF00153.22 ESS70372.1 - 8.4e-64 211.3 2.9 5.6e-22 77.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ATP-synt_C PF00137.16 ESS70373.1 - 2.5e-16 59.2 12.0 2.5e-16 59.2 8.3 1.7 2 0 0 2 2 2 1 ATP synthase subunit C UCH PF00443.24 ESS70374.1 - 6.4e-43 146.7 0.0 9.4e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS70374.1 - 1.6e-17 63.9 0.0 2.7e-17 63.1 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pkinase PF00069.20 ESS70375.1 - 0.033 13.3 0.1 0.61 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain SNF2_N PF00176.18 ESS70376.1 - 3.2e-34 118.0 0.0 4.8e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESS70376.1 - 4.3e-09 36.1 0.0 1.2e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS70376.1 - 8e-06 25.8 0.0 5.8e-05 23.0 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Ribosomal_S4e PF00900.15 ESS70376.1 - 0.16 11.6 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 Ribosomal family S4e Npa1 PF11707.3 ESS70377.1 - 3.3e-05 23.0 0.0 7.4e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Glycos_transf_2 PF00535.21 ESS70378.1 - 0.0024 17.5 0.0 0.059 13.0 0.0 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESS70378.1 - 0.0042 16.9 0.0 0.0085 15.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 V-ATPase_C PF03223.10 ESS70378.1 - 0.13 11.1 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit C TRM13 PF05206.9 ESS70379.1 - 3e-15 56.1 0.0 4.4e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 Methyltransf_32 PF13679.1 ESS70379.1 - 1.5e-08 34.4 0.5 1.1e-07 31.6 0.3 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESS70379.1 - 0.0023 17.1 0.3 0.024 13.8 0.0 2.3 3 0 0 3 3 3 1 O-methyltransferase PCMT PF01135.14 ESS70379.1 - 0.039 13.4 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.1 ESS70379.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain ENT PF03735.9 ESS70380.1 - 0.00057 19.5 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 ENT domain DnaJ PF00226.26 ESS70381.1 - 0.0031 17.2 0.6 0.0055 16.4 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain UPF0147 PF03685.8 ESS70382.1 - 0.00042 20.1 0.0 0.0029 17.4 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0147) FliD_C PF07195.7 ESS70382.1 - 1.9 7.7 11.1 1.7 7.8 0.8 3.7 2 2 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus LRR_4 PF12799.2 ESS70384.1 - 1.1e-35 120.7 37.5 4.4e-07 29.3 0.5 10.5 8 3 3 11 11 11 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70384.1 - 5.9e-22 77.2 48.5 2.2e-07 30.5 5.6 9.0 5 3 5 10 10 10 7 Leucine rich repeat LRR_9 PF14580.1 ESS70384.1 - 3.9e-21 75.3 7.7 1e-07 31.6 0.0 5.8 2 1 4 6 6 6 4 Leucine-rich repeat LRR_6 PF13516.1 ESS70384.1 - 2.2e-08 33.3 33.2 5.6 7.3 0.0 12.5 10 2 2 12 12 12 4 Leucine Rich repeat LRR_7 PF13504.1 ESS70384.1 - 8.9e-08 31.1 38.6 14 6.4 0.5 12.9 13 0 0 13 13 13 3 Leucine rich repeat LRR_1 PF00560.28 ESS70384.1 - 2.2e-07 29.9 41.8 7.1 7.0 0.0 13.1 12 2 0 12 12 12 5 Leucine Rich Repeat LRR_4 PF12799.2 ESS70385.1 - 7.6e-16 57.3 14.9 4.8e-07 29.2 0.1 4.3 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70385.1 - 9.4e-11 41.3 16.1 5.9e-06 25.9 0.8 3.6 3 1 2 5 5 5 4 Leucine rich repeat LRR_9 PF14580.1 ESS70385.1 - 1.5e-08 34.3 0.2 2.2e-07 30.6 0.1 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 ESS70385.1 - 0.00037 20.1 8.8 14 6.1 0.7 6.2 4 2 1 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 ESS70385.1 - 0.14 12.4 9.2 65 4.4 0.1 6.2 5 1 1 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 ESS70385.1 - 2.6 8.3 10.2 6 7.2 1.0 4.9 3 3 2 5 5 5 0 Leucine Rich repeat ThiF PF00899.16 ESS70387.1 - 1.3e-33 115.7 0.4 2.4e-33 114.8 0.3 1.4 1 0 0 1 1 1 1 ThiF family RRM_6 PF14259.1 ESS70390.1 - 0.028 14.4 0.0 4.1 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Peptidase_C12 PF01088.16 ESS70391.1 - 6.5e-59 198.6 0.0 9.3e-59 198.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Rootletin PF15035.1 ESS70391.1 - 0.028 14.4 1.7 0.055 13.4 1.2 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion BBP1_C PF15272.1 ESS70391.1 - 0.04 13.4 2.1 0.06 12.8 1.4 1.3 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal hNIFK_binding PF12196.3 ESS70392.1 - 0.12 11.8 0.1 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Actin PF00022.14 ESS70393.1 - 2.9e-93 312.4 0.0 3.4e-93 312.2 0.0 1.0 1 0 0 1 1 1 1 Actin TPR_11 PF13414.1 ESS70394.1 - 1.1e-07 31.3 1.0 3.5e-07 29.7 0.7 1.9 1 1 0 1 1 1 1 TPR repeat TPR_12 PF13424.1 ESS70394.1 - 6.1e-05 22.8 1.1 0.22 11.4 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat SET PF00856.23 ESS70394.1 - 6.6e-05 23.2 0.1 0.001 19.3 0.0 2.2 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.12 ESS70394.1 - 0.00038 20.1 1.5 0.0058 16.4 0.4 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESS70394.1 - 0.00098 18.6 1.1 0.00098 18.6 0.7 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70394.1 - 0.011 15.4 2.2 0.24 11.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70394.1 - 0.054 14.1 0.3 1.8 9.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70394.1 - 0.091 12.5 0.4 0.83 9.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.16 ESS70397.1 - 2.2e-71 240.7 0.0 2.5e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Phosphodiest PF01663.17 ESS70399.1 - 1.8e-07 30.8 1.1 1.8e-07 30.8 0.7 2.2 3 0 0 3 3 3 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 ESS70399.1 - 0.017 14.5 0.3 0.033 13.5 0.2 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily Rsm22 PF09243.5 ESS70400.1 - 4.3e-28 98.1 4.1 3.3e-16 59.1 0.1 3.6 4 0 0 4 4 4 2 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_18 PF12847.2 ESS70400.1 - 4.1e-05 24.1 0.2 0.38 11.3 0.0 3.5 3 0 0 3 3 3 1 Methyltransferase domain ERAP1_C PF11838.3 ESS70400.1 - 0.0047 16.2 1.2 0.02 14.1 0.1 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Methyltransf_23 PF13489.1 ESS70400.1 - 0.065 12.9 0.0 1.7 8.3 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESS70400.1 - 0.083 13.3 0.0 6.8 7.2 0.0 3.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESS70400.1 - 0.4 10.7 3.7 1.7 8.6 2.5 2.1 1 1 0 1 1 1 0 Methyltransferase domain Fumerase PF05681.9 ESS70401.1 - 6.7e-87 291.0 0.0 8.7e-87 290.6 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.7 ESS70401.1 - 2.7e-78 261.8 0.0 4.6e-78 261.0 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus LRR_6 PF13516.1 ESS70402.1 - 6.6e-18 62.7 1.0 0.32 11.2 0.0 8.2 9 0 0 9 9 9 5 Leucine Rich repeat LRR_1 PF00560.28 ESS70402.1 - 5.2e-14 50.1 1.3 0.42 10.8 0.0 7.6 7 1 0 7 7 7 4 Leucine Rich Repeat LRR_4 PF12799.2 ESS70402.1 - 3.9e-13 48.6 4.7 0.0015 18.1 0.9 6.5 4 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESS70402.1 - 1.8e-09 36.2 10.5 0.63 10.4 0.0 7.6 7 0 0 7 7 7 3 Leucine rich repeat LRR_8 PF13855.1 ESS70402.1 - 1.9e-08 33.9 6.5 0.092 12.5 0.0 5.6 4 1 1 5 5 5 3 Leucine rich repeat DALR_1 PF05746.10 ESS70404.1 - 0.033 14.1 0.6 0.89 9.5 0.1 3.2 2 0 0 2 2 2 0 DALR anticodon binding domain FANCL_C PF11793.3 ESS70404.1 - 0.071 13.0 2.8 0.18 11.7 2.0 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain Nop14 PF04147.7 ESS70404.1 - 0.18 9.6 2.2 0.38 8.6 1.5 1.5 1 0 0 1 1 1 0 Nop14-like family zf-C3HC4_3 PF13920.1 ESS70404.1 - 0.19 11.4 3.9 0.59 9.8 2.7 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PBP1_TM PF14812.1 ESS70404.1 - 0.24 11.7 2.8 0.65 10.3 1.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C3HC4 PF00097.20 ESS70404.1 - 0.25 11.0 4.2 0.68 9.6 2.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Daxx PF03344.10 ESS70404.1 - 2.3 6.5 7.9 3.6 5.9 5.5 1.1 1 0 0 1 1 1 0 Daxx Family BUD22 PF09073.5 ESS70404.1 - 2.4 7.1 7.8 3.7 6.5 5.4 1.2 1 0 0 1 1 1 0 BUD22 NIF PF03031.13 ESS70405.1 - 3.4e-31 108.0 0.1 5.5e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.7 ESS70405.1 - 0.076 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF705) HAD_2 PF13419.1 ESS70405.1 - 0.087 13.0 0.0 0.24 11.5 0.0 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase WD40 PF00400.27 ESS70406.1 - 1.4e-16 59.6 8.2 2.4e-09 36.6 0.3 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat CPSF_A PF03178.10 ESS70406.1 - 0.0036 16.4 0.0 0.12 11.4 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region DUF3312 PF11768.3 ESS70406.1 - 0.043 12.0 0.0 0.86 7.7 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3312) Metallophos PF00149.23 ESS70407.1 - 0.016 14.6 0.0 0.025 13.9 0.0 1.3 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase Metallophos PF00149.23 ESS70408.1 - 2.3e-06 27.1 0.0 3.5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DEAD PF00270.24 ESS70409.1 - 4e-30 104.5 0.6 4.9e-30 104.2 0.4 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS70409.1 - 0.028 14.2 0.0 0.039 13.7 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CAF1C_H4-bd PF12265.3 ESS70410.1 - 5.2e-14 51.8 0.7 1e-13 50.9 0.2 1.7 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 ESS70410.1 - 2.5e-11 43.0 15.0 0.00082 19.1 0.2 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat TFIIS_C PF01096.13 ESS70411.1 - 5.3e-17 61.1 10.9 5.3e-17 61.1 7.5 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.9 ESS70411.1 - 8.1e-11 42.0 0.1 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Baculo_LEF5_C PF11792.3 ESS70411.1 - 0.11 11.9 2.3 0.23 10.8 1.6 1.6 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Elf1 PF05129.8 ESS70411.1 - 2.9 7.6 7.2 5.1 6.8 3.9 2.1 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like TFIIS_M PF07500.9 ESS70412.1 - 4.4e-07 29.9 0.2 7.2e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain DUF2752 PF10825.3 ESS70412.1 - 0.064 13.2 2.1 0.23 11.5 1.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) TFIIS_C PF01096.13 ESS70412.1 - 0.09 12.4 6.5 0.47 10.1 4.5 2.2 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) HEAT_2 PF13646.1 ESS70413.1 - 5.1e-13 49.1 0.4 3.2e-06 27.3 0.0 4.1 3 1 1 4 4 4 4 HEAT repeats HEAT PF02985.17 ESS70413.1 - 2.3e-09 36.5 10.0 0.0026 17.6 0.0 6.7 6 0 0 6 6 6 3 HEAT repeat Vac14_Fab1_bd PF12755.2 ESS70413.1 - 0.01 16.2 0.9 0.55 10.6 0.0 3.7 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region SusD PF07980.6 ESS70413.1 - 0.098 12.1 0.2 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 SusD family Cnd1 PF12717.2 ESS70413.1 - 0.38 10.5 4.8 1.2 8.8 0.1 3.4 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESS70413.1 - 0.66 10.5 3.5 15 6.2 0.0 4.2 4 1 1 5 5 5 0 HEAT-like repeat AAA PF00004.24 ESS70414.1 - 4.1e-29 101.4 0.0 1.8e-28 99.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS70414.1 - 2.4e-06 27.6 2.7 0.0006 19.8 0.4 3.6 3 1 1 4 4 4 1 AAA ATPase domain AAA_19 PF13245.1 ESS70414.1 - 5.2e-05 22.9 0.8 0.0052 16.5 0.0 3.2 2 0 0 2 2 2 1 Part of AAA domain AAA_5 PF07728.9 ESS70414.1 - 0.00033 20.3 0.0 0.0036 17.0 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.7 ESS70414.1 - 0.00043 19.9 0.0 2.1 7.9 0.0 3.5 2 1 1 3 3 3 2 NACHT domain AAA_14 PF13173.1 ESS70414.1 - 0.00073 19.4 0.0 0.044 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESS70414.1 - 0.00078 19.5 0.3 0.037 14.1 0.1 3.4 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESS70414.1 - 0.0011 17.7 0.0 0.0018 17.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_17 PF13207.1 ESS70414.1 - 0.0041 17.9 0.0 0.013 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESS70414.1 - 0.0079 15.6 0.0 0.019 14.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESS70414.1 - 0.024 13.8 0.1 0.056 12.6 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESS70414.1 - 0.024 14.4 0.0 0.059 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESS70414.1 - 0.076 12.4 0.0 0.2 11.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.17 ESS70414.1 - 0.13 11.0 0.2 0.95 8.2 0.0 2.3 1 1 1 2 2 2 0 NB-ARC domain AAA_18 PF13238.1 ESS70414.1 - 0.18 12.0 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Phosducin PF02114.11 ESS70415.1 - 5.5e-10 38.4 0.2 9.1e-10 37.6 0.1 1.3 1 1 0 1 1 1 1 Phosducin PSD1 PF07587.6 ESS70416.1 - 0.14 11.5 2.4 0.18 11.1 1.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1553) Herpes_UL46 PF03387.9 ESS70416.1 - 0.15 10.2 2.3 0.63 8.1 0.3 2.0 1 1 1 2 2 2 0 Herpesvirus UL46 protein Ank_2 PF12796.2 ESS70417.1 - 8.3e-45 151.0 1.8 2.2e-15 56.7 0.0 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESS70417.1 - 1.4e-41 138.2 0.9 1.4e-07 30.9 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 ESS70417.1 - 2.5e-40 136.1 3.5 2.2e-07 31.1 0.0 5.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESS70417.1 - 9.1e-35 117.9 0.8 3.8e-10 39.6 0.0 4.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS70417.1 - 5.9e-27 91.0 3.7 0.0021 18.1 0.0 7.1 8 0 0 8 8 7 6 Ankyrin repeat TPR_11 PF13414.1 ESS70417.1 - 7.3e-16 57.5 2.3 1.4e-09 37.4 0.6 2.4 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESS70417.1 - 2.6e-07 29.9 1.8 0.00013 21.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70417.1 - 3.2e-05 23.4 3.4 0.011 15.5 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESS70417.1 - 3.4e-05 23.7 1.4 0.31 11.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70417.1 - 0.024 14.4 0.3 0.065 13.0 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70417.1 - 0.032 14.8 0.7 0.19 12.4 0.0 2.7 2 1 1 3 3 2 0 Tetratricopeptide repeat Apc3 PF12895.2 ESS70417.1 - 0.047 13.8 0.4 0.12 12.5 0.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.27 ESS70418.1 - 5.5e-13 48.2 10.2 6.2e-06 25.8 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat PARP_regulatory PF01358.13 ESS70419.1 - 2.1e-26 92.2 0.0 3.4e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Poly A polymerase regulatory subunit Enkurin PF13864.1 ESS70420.1 - 6.5e-22 77.5 1.9 1.1e-21 76.9 1.3 1.3 1 0 0 1 1 1 1 Calmodulin-binding DUF1602 PF07673.9 ESS70420.1 - 0.017 14.6 0.1 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1602) Herpes_ICP4_N PF03584.10 ESS70420.1 - 0.081 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region DUF4482 PF14818.1 ESS70420.1 - 0.13 12.9 3.6 0.24 12.0 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) HMG_box_2 PF09011.5 ESS70420.1 - 0.15 12.4 1.6 0.2 12.0 0.3 1.9 2 0 0 2 2 2 0 HMG-box domain zf-RING_2 PF13639.1 ESS70421.1 - 3.2e-08 33.2 2.0 3.2e-08 33.2 1.4 3.9 2 1 1 3 3 3 1 Ring finger domain DUF4315 PF14193.1 ESS70422.1 - 8.2 6.4 11.0 0.18 11.7 0.3 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4315) CutC PF03932.9 ESS70425.1 - 9e-62 207.9 0.1 1e-61 207.7 0.1 1.0 1 0 0 1 1 1 1 CutC family AP_endonuc_2 PF01261.19 ESS70425.1 - 0.0053 16.0 0.1 0.031 13.5 0.0 2.0 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel ANTH PF07651.11 ESS70426.1 - 3.6e-27 94.7 0.0 4.8e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 ESS70426.1 - 4.9e-08 32.8 0.3 1.1e-07 31.7 0.2 1.5 1 1 0 1 1 1 1 ENTH domain BCDHK_Adom3 PF10436.4 ESS70428.1 - 2.2e-33 115.0 0.1 3.4e-33 114.4 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESS70428.1 - 5.8e-05 22.7 0.0 0.00014 21.5 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESS70428.1 - 0.0014 18.2 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DGF-1_5 PF11038.3 ESS70431.1 - 1.8e-161 535.8 18.3 1.8e-161 535.8 12.7 2.3 3 0 0 3 3 3 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DGF-1_C PF11040.3 ESS70431.1 - 7.1e-48 160.4 1.4 1.6e-47 159.3 1.0 1.6 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DGF-1_4 PF11024.3 ESS70431.1 - 1.3e-38 131.1 16.8 3.3e-38 129.9 11.7 1.7 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RHSP PF07999.6 ESS70432.1 - 1.8e-19 69.6 0.3 2.9e-19 68.9 0.2 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.6 ESS70433.1 - 4.2e-39 134.3 0.0 4.7e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein SNF2_N PF00176.18 ESS70464.1 - 2.4e-28 98.7 0.1 4.1e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HNH PF01844.18 ESS70464.1 - 2.7e-09 36.7 0.0 1.1e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 HNH endonuclease Helicase_C PF00271.26 ESS70464.1 - 1.2e-05 25.0 0.0 3.3e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS70464.1 - 0.007 16.2 0.0 0.091 12.5 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Pkinase PF00069.20 ESS70465.1 - 8.1e-41 139.8 0.0 2.8e-27 95.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70465.1 - 6.9e-18 64.6 0.7 1.9e-09 36.9 0.4 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase RWD PF05773.17 ESS70465.1 - 8.7e-09 35.2 0.0 1.7e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 RWD domain APH PF01636.18 ESS70465.1 - 0.001 18.8 0.0 0.06 13.0 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS70465.1 - 0.0014 17.6 0.0 0.016 14.1 0.0 2.4 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 ESS70465.1 - 0.0041 16.2 0.0 0.0076 15.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NCD1 PF04904.8 ESS70465.1 - 0.058 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) YrbL-PhoP_reg PF10707.4 ESS70465.1 - 0.081 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL CENP-Q PF13094.1 ESS70467.1 - 0.0058 16.6 6.6 0.0058 16.6 4.6 3.3 2 1 1 3 3 3 1 CENP-Q, a CENPA-CAD centromere complex subunit ADIP PF11559.3 ESS70467.1 - 0.015 15.2 38.9 0.47 10.3 5.0 3.5 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding Vip3A_N PF12495.3 ESS70467.1 - 0.016 14.8 2.7 0.025 14.2 0.9 1.9 1 1 1 2 2 2 0 Vegetative insecticide protein 3A N terminal Fib_alpha PF08702.5 ESS70467.1 - 0.022 14.8 27.7 0.033 14.3 6.3 3.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.2 ESS70467.1 - 0.023 14.5 9.7 0.023 14.5 6.7 3.7 2 1 0 3 3 3 0 Tropomyosin like Reo_sigmaC PF04582.7 ESS70467.1 - 0.05 12.7 7.3 0.055 12.6 2.9 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Lebercilin PF15619.1 ESS70467.1 - 0.084 12.2 39.9 0.36 10.2 5.2 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CCDC155 PF14662.1 ESS70467.1 - 0.092 12.3 42.1 0.091 12.3 16.1 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Peripla_BP_2 PF01497.13 ESS70467.1 - 0.098 11.7 4.7 0.3 10.1 0.4 2.4 2 1 0 2 2 2 0 Periplasmic binding protein Atg14 PF10186.4 ESS70467.1 - 0.31 9.9 31.7 0.77 8.6 2.2 2.8 2 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 NPV_P10 PF05531.7 ESS70467.1 - 0.35 11.1 14.5 5 7.4 0.6 4.3 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4250 PF14056.1 ESS70467.1 - 0.4 10.4 5.9 4.4 7.0 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) Myb_DNA-bind_5 PF13873.1 ESS70467.1 - 0.57 10.1 16.3 0.26 11.2 2.5 3.5 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain Spc7 PF08317.6 ESS70467.1 - 0.64 8.6 41.3 1.1 7.8 6.1 2.9 1 1 1 3 3 3 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.7 ESS70467.1 - 0.76 9.6 13.7 3.3 7.5 0.3 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Bacillus_HBL PF05791.6 ESS70467.1 - 0.86 8.9 21.8 0.18 11.1 0.7 3.0 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF479 PF04336.7 ESS70467.1 - 1.1 9.3 10.0 0.2 11.7 1.1 3.3 2 1 1 3 3 3 0 Protein of unknown function, DUF479 Tropomyosin PF00261.15 ESS70467.1 - 1.3 8.0 47.9 0.26 10.3 8.7 3.0 1 1 1 2 2 2 0 Tropomyosin DUF4294 PF14127.1 ESS70467.1 - 1.7 8.2 16.2 1.5 8.4 0.5 3.2 2 1 2 4 4 4 0 Domain of unknown function (DUF4294) ATG16 PF08614.6 ESS70467.1 - 2.1 8.1 40.5 2.1 8.0 5.1 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.3 ESS70467.1 - 3.9 4.6 39.0 0.35 8.1 16.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Endotoxin_N PF03945.9 ESS70467.1 - 4 6.7 7.7 12 5.1 0.2 3.0 3 0 0 3 3 3 0 delta endotoxin, N-terminal domain DUF4298 PF14131.1 ESS70467.1 - 4.1 7.3 16.4 6.9 6.6 1.1 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4298) Calici_MSP PF05752.6 ESS70467.1 - 6.1 6.4 10.7 0.7 9.4 4.3 1.8 2 1 0 2 2 2 0 Calicivirus minor structural protein V-ATPase_H_C PF11698.3 ESS70467.1 - 7.7 6.4 10.9 4.7 7.1 3.3 3.1 1 1 0 2 2 2 0 V-ATPase subunit H Nup54 PF13874.1 ESS70467.1 - 9.8 5.8 32.8 1.9 8.1 8.4 3.5 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 GRIP PF01465.15 ESS70468.1 - 4.2e-16 58.1 0.2 1e-15 56.9 0.2 1.7 1 0 0 1 1 1 1 GRIP domain DUF2730 PF10805.3 ESS70468.1 - 0.0021 17.7 0.7 0.0021 17.7 0.5 6.6 4 3 0 5 5 5 1 Protein of unknown function (DUF2730) Tropomyosin_1 PF12718.2 ESS70468.1 - 0.006 16.4 4.3 0.006 16.4 3.0 7.7 6 1 0 7 7 7 3 Tropomyosin like IncA PF04156.9 ESS70468.1 - 0.088 12.3 96.5 0.08 12.5 7.4 7.1 5 1 2 7 7 7 0 IncA protein NPV_P10 PF05531.7 ESS70468.1 - 0.72 10.1 30.0 13 6.0 0.4 7.9 5 2 1 6 6 6 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 ESS70468.1 - 1.8 8.6 66.1 0.21 11.6 6.3 7.5 5 1 2 7 7 7 0 Fibrinogen alpha/beta chain family ADIP PF11559.3 ESS70468.1 - 3.6 7.4 91.3 1 9.2 4.2 7.8 6 1 0 7 7 7 0 Afadin- and alpha -actinin-Binding V-ATPase_H_C PF11698.3 ESS70468.1 - 3.7 7.4 23.1 1.1 9.2 0.7 4.5 3 2 1 4 4 4 0 V-ATPase subunit H RRM_1 PF00076.17 ESS70469.1 - 0.0004 19.9 0.0 0.00079 19.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MORN PF02493.15 ESS70470.1 - 7.3e-46 151.2 65.5 2.9e-08 32.9 0.2 10.4 10 0 0 10 10 10 10 MORN repeat Prefoldin PF02996.12 ESS70470.1 - 0.22 11.1 0.0 0.47 10.1 0.0 1.4 1 0 0 1 1 1 0 Prefoldin subunit tRNA-synt_2b PF00587.20 ESS70471.1 - 3.4e-30 104.8 0.0 5.2e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 ESS70471.1 - 5.9e-16 58.4 2.4 1.1e-13 51.0 0.3 2.4 1 1 1 2 2 2 2 Seryl-tRNA synthetase N-terminal domain Pkinase PF00069.20 ESS70472.1 - 8.7e-49 166.0 0.0 1.1e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70472.1 - 7.1e-24 84.2 0.0 1e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70472.1 - 8.8e-08 31.4 0.0 1.6e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS70472.1 - 1.2e-05 25.1 0.0 4e-05 23.4 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESS70472.1 - 0.028 14.0 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.6 ESS70472.1 - 0.037 12.8 0.0 0.078 11.7 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 RIO1 PF01163.17 ESS70472.1 - 0.11 11.8 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 RIO1 family NIF3 PF01784.13 ESS70474.1 - 1.9e-64 217.5 0.0 2.3e-64 217.2 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) DUF2090 PF09863.4 ESS70474.1 - 0.085 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) PSP1 PF04468.7 ESS70475.1 - 2.6e-32 110.6 0.2 4.1e-32 110.0 0.2 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DEAD PF00270.24 ESS70478.1 - 4.5e-24 84.8 0.0 9.9e-24 83.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS70478.1 - 3e-07 30.1 0.0 8.6e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS70478.1 - 4.2e-05 23.4 0.0 0.00011 22.1 0.0 1.8 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 ESS70478.1 - 0.043 13.2 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ESS70478.1 - 0.058 12.6 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein LRR_6 PF13516.1 ESS70479.1 - 1.7e-06 27.5 1.9 0.0055 16.6 0.1 3.8 4 0 0 4 4 4 2 Leucine Rich repeat Pyrophosphatase PF00719.14 ESS70480.1 - 3.1e-51 172.9 0.0 5e-51 172.2 0.0 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase Pep_M12B_propep PF01562.14 ESS70480.1 - 0.048 13.4 0.0 0.095 12.4 0.0 1.5 1 1 0 1 1 1 0 Reprolysin family propeptide Rad51 PF08423.6 ESS70481.1 - 8.8e-14 51.0 0.2 2e-13 49.8 0.1 1.6 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.1 ESS70481.1 - 5.1e-10 39.0 0.1 8.6e-10 38.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ESS70481.1 - 2.8e-05 23.3 0.0 5.6e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.10 ESS70481.1 - 0.0013 17.6 0.1 0.043 12.7 0.0 2.1 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.1 ESS70481.1 - 0.0014 18.7 0.0 0.0038 17.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain RecA PF00154.16 ESS70481.1 - 0.0017 17.4 0.2 0.0037 16.3 0.0 1.5 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_19 PF13245.1 ESS70481.1 - 0.022 14.5 0.2 0.069 12.9 0.2 2.0 1 1 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 ESS70481.1 - 0.025 14.2 0.0 0.1 12.2 0.0 2.0 1 1 0 1 1 1 0 NACHT domain DEAD PF00270.24 ESS70481.1 - 0.069 12.6 0.0 0.28 10.6 0.0 2.0 2 1 0 2 2 2 0 DEAD/DEAH box helicase Zot PF05707.7 ESS70481.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_17 PF13207.1 ESS70481.1 - 0.15 12.8 0.0 0.49 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESS70481.1 - 0.2 10.5 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Proteasome PF00227.21 ESS70482.1 - 1.1e-60 204.2 0.0 1.5e-60 203.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESS70482.1 - 1.2e-14 53.2 0.2 1.9e-14 52.6 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Pkinase PF00069.20 ESS70483.1 - 3.8e-52 177.0 0.0 1.7e-51 174.9 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70483.1 - 1.8e-30 105.8 0.2 2.4e-26 92.3 0.1 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS70483.1 - 4.7e-06 25.7 0.0 0.013 14.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like YrbL-PhoP_reg PF10707.4 ESS70483.1 - 0.0016 17.8 0.2 0.083 12.2 0.0 2.3 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL APH PF01636.18 ESS70483.1 - 0.0079 15.9 1.1 0.12 12.1 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESS70483.1 - 0.021 14.1 0.7 0.052 12.8 0.5 1.6 1 1 0 1 1 1 0 RIO1 family YukC PF10140.4 ESS70483.1 - 0.056 12.0 0.0 0.094 11.2 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Kdo PF06293.9 ESS70483.1 - 0.087 11.8 0.1 0.27 10.2 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESS70484.1 - 3.1e-51 174.0 0.0 4.8e-51 173.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70484.1 - 5.3e-30 104.3 0.0 9.3e-30 103.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70484.1 - 4.9e-08 32.2 0.0 7.6e-08 31.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS70484.1 - 0.00023 20.9 0.2 0.37 10.4 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 ESS70484.1 - 0.00064 19.1 0.1 0.0012 18.1 0.1 1.4 1 0 0 1 1 1 1 RIO1 family PEPCK_ATP PF01293.15 ESS70485.1 - 0.11 11.0 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase FAD_binding_6 PF00970.19 ESS70486.1 - 1.2e-07 31.8 0.0 4.3e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESS70486.1 - 3.4e-06 27.5 0.0 8.5e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain WD40 PF00400.27 ESS70487.1 - 1e-21 75.9 15.1 0.00022 20.9 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESS70487.1 - 0.026 13.2 0.3 5.8 5.5 0.1 3.0 1 1 2 3 3 3 0 Nup133 N terminal like Nup160 PF11715.3 ESS70487.1 - 0.041 12.0 2.3 0.79 7.7 0.4 2.8 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ATG16 PF08614.6 ESS70487.1 - 0.11 12.3 20.6 0.19 11.5 14.3 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2205 PF10224.4 ESS70487.1 - 0.14 11.7 10.6 0.26 10.8 0.1 2.8 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) GalP_UDP_transf PF01087.17 ESS70487.1 - 0.14 12.1 0.5 0.35 10.9 0.4 1.6 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, N-terminal domain ERp29 PF07749.7 ESS70487.1 - 0.33 11.5 5.3 1.4 9.6 2.8 2.3 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Acetyltransf_11 PF13720.1 ESS70487.1 - 0.86 9.8 4.0 18 5.6 0.1 2.6 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Syntaxin PF00804.20 ESS70487.1 - 1.8 8.7 8.5 5.4 7.2 5.9 1.8 1 0 0 1 1 1 0 Syntaxin DUF972 PF06156.8 ESS70487.1 - 2 8.7 16.5 3.1 8.1 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Ribonuc_2-5A PF06479.7 ESS70488.1 - 0.0045 16.8 1.9 0.01 15.6 1.3 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A PIF1 PF05970.9 ESS70491.1 - 1.8e-34 119.3 1.2 4e-28 98.4 0.2 3.2 2 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 ESS70491.1 - 1.1e-14 54.5 0.0 1.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS70491.1 - 0.00031 20.4 0.3 0.00091 18.9 0.2 1.8 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 ESS70491.1 - 0.00042 19.7 0.3 0.0012 18.2 0.2 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.1 ESS70491.1 - 0.0015 18.7 0.2 0.0079 16.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESS70491.1 - 0.017 14.7 0.0 7.4 6.0 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.1 ESS70491.1 - 0.043 13.7 4.7 0.35 10.8 1.7 3.1 2 1 0 2 2 2 0 AAA ATPase domain PhoH PF02562.11 ESS70491.1 - 0.12 11.5 0.0 0.27 10.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF2730 PF10805.3 ESS70491.1 - 0.15 11.8 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) PIF1 PF05970.9 ESS70492.1 - 1.7e-37 129.2 0.7 2.8e-31 108.7 0.1 3.5 2 1 1 3 3 3 3 PIF1-like helicase AAA_30 PF13604.1 ESS70492.1 - 2e-16 60.1 0.0 4.4e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESS70492.1 - 2.7e-06 27.5 0.0 8.5e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS70492.1 - 8.5e-05 22.2 2.6 0.00013 21.6 0.5 2.3 2 0 0 2 2 2 1 Part of AAA domain Herpes_Helicase PF02689.9 ESS70492.1 - 0.00061 17.6 1.0 0.042 11.5 0.0 2.4 3 0 0 3 3 3 2 Helicase AAA_5 PF07728.9 ESS70492.1 - 0.0027 17.4 0.1 0.011 15.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESS70492.1 - 0.0034 16.5 0.2 0.0067 15.6 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 ESS70492.1 - 0.0048 16.1 0.1 0.011 14.9 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein AAA_16 PF13191.1 ESS70492.1 - 0.0072 16.3 1.1 0.039 13.9 0.2 2.5 1 1 1 2 2 2 1 AAA ATPase domain T2SE PF00437.15 ESS70492.1 - 0.014 14.2 0.1 0.028 13.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Viral_helicase1 PF01443.13 ESS70492.1 - 0.025 14.1 0.2 5.9 6.3 0.0 2.9 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 ESS70492.1 - 0.028 14.5 0.0 0.1 12.7 0.0 2.1 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2075 PF09848.4 ESS70492.1 - 0.071 12.0 0.0 0.14 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF3584 PF12128.3 ESS70492.1 - 0.071 10.4 1.0 2.8 5.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) UPF0079 PF02367.12 ESS70492.1 - 0.08 12.5 0.2 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA PF00004.24 ESS70492.1 - 0.089 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.16 ESS70492.1 - 0.18 11.0 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_24 PF13479.1 ESS70492.1 - 0.19 11.3 0.0 1.2 8.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain 14-3-3 PF00244.15 ESS70493.1 - 2.9e-96 321.1 5.6 3.4e-96 320.8 3.8 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 ESS70493.1 - 0.00072 19.4 1.4 0.045 13.6 0.4 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70493.1 - 0.0099 15.5 2.3 8.1 6.4 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESS70493.1 - 0.011 15.3 0.5 0.076 12.6 0.1 2.4 2 1 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 ESS70493.1 - 0.053 13.4 2.8 6.4 6.9 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat OPA3 PF07047.7 ESS70494.1 - 9.7e-14 51.2 0.0 3.4e-13 49.5 0.0 1.8 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) DUF2568 PF10823.3 ESS70494.1 - 0.045 13.9 0.0 0.097 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2568) LMBR1 PF04791.11 ESS70495.1 - 0.0085 14.7 8.5 0.049 12.2 0.0 3.0 1 1 1 2 2 2 1 LMBR1-like membrane protein DUF2779 PF11074.3 ESS70496.1 - 1.9e-46 157.2 0.1 5.2e-46 155.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function(DUF2779) Usp PF00582.21 ESS70497.1 - 6.3e-05 23.1 10.5 0.029 14.5 0.0 3.7 3 1 1 4 4 4 3 Universal stress protein family PhyH PF05721.8 ESS70497.1 - 0.11 12.5 0.2 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) TTL PF03133.10 ESS70498.1 - 7.2e-69 231.9 0.9 1.5e-68 230.8 0.0 1.9 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ESS70498.1 - 1.7e-06 27.0 0.1 0.001 17.9 0.0 3.3 2 1 1 3 3 3 1 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 ESS70498.1 - 0.013 15.2 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_3 PF02655.9 ESS70498.1 - 0.034 14.0 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain BOP1NT PF08145.7 ESS70499.1 - 4.1e-86 288.9 8.1 5.9e-86 288.4 5.6 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 ESS70499.1 - 5.7e-26 89.4 0.6 3.4e-10 39.3 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat BpuJI_N PF11564.3 ESS70499.1 - 0.0016 17.4 0.0 0.0027 16.7 0.0 1.2 1 0 0 1 1 1 1 Restriction endonuclease BpuJI - N terminal RCC1 PF00415.13 ESS70500.1 - 6.9e-25 87.0 18.5 8.1e-13 48.3 0.1 7.8 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESS70500.1 - 8.9e-09 34.7 21.5 0.00055 19.4 0.2 5.8 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat OST-HTH PF12872.2 ESS70501.1 - 0.1 12.4 0.0 0.47 10.3 0.0 2.1 1 0 0 1 1 1 0 OST-HTH/LOTUS domain LRR_4 PF12799.2 ESS70503.1 - 1.7e-18 65.7 7.0 2.8e-05 23.6 0.2 4.9 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESS70503.1 - 4.4e-05 23.1 0.1 0.0057 16.2 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.1 ESS70503.1 - 4.5e-05 23.1 14.9 0.16 11.7 0.5 4.7 4 1 1 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 ESS70503.1 - 0.0001 21.9 1.9 20 5.9 0.0 5.5 4 0 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 ESS70503.1 - 0.0019 18.0 12.5 6.1 7.2 0.1 6.3 4 3 3 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.28 ESS70503.1 - 0.0041 16.9 17.9 5 7.5 0.1 7.3 6 3 2 8 8 8 3 Leucine Rich Repeat WD40 PF00400.27 ESS70504.1 - 1.1e-06 28.2 18.9 0.0018 18.0 0.2 4.8 6 0 0 6 6 6 3 WD domain, G-beta repeat DNA_ligase_A_M PF01068.16 ESS70505.1 - 1.3e-08 34.4 0.0 0.00012 21.5 0.0 2.4 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.1 ESS70505.1 - 0.018 14.6 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 DNA ligase OB-like domain PUF PF00806.14 ESS70506.1 - 1.9e-11 42.7 4.7 0.37 10.3 0.0 8.5 9 0 0 9 9 9 4 Pumilio-family RNA binding repeat CARD PF00619.16 ESS70506.1 - 0.02 14.6 0.0 0.096 12.5 0.0 2.2 1 0 0 1 1 1 0 Caspase recruitment domain PAM2 PF07145.10 ESS70507.1 - 0.087 12.3 0.1 0.21 11.1 0.1 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Pox_MCEL PF03291.11 ESS70508.1 - 1.2e-07 30.8 0.1 1.8e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.1 ESS70508.1 - 0.0003 21.0 0.0 0.00085 19.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS70508.1 - 0.00063 20.1 0.0 0.0024 18.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESS70508.1 - 0.0034 17.0 0.1 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PHF5 PF03660.9 ESS70508.1 - 0.04 13.9 2.4 0.074 13.1 1.7 1.3 1 0 0 1 1 1 0 PHF5-like protein Methyltransf_11 PF08241.7 ESS70508.1 - 0.088 13.3 0.0 0.65 10.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Sgf11 PF08209.6 ESS70508.1 - 0.53 9.6 4.4 1.7 8.0 0.3 2.7 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Zn_Tnp_IS1 PF03811.8 ESS70508.1 - 9.4 5.8 8.6 6.6 6.3 2.2 2.4 2 0 0 2 2 2 0 InsA N-terminal domain TPR_11 PF13414.1 ESS70509.1 - 1.3e-27 95.2 28.7 2.7e-13 49.3 2.3 4.9 3 1 2 5 5 5 4 TPR repeat TPR_1 PF00515.23 ESS70509.1 - 2.2e-24 84.0 21.6 8.4e-09 34.6 0.4 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70509.1 - 1.9e-17 61.6 22.8 9.8e-06 25.1 0.2 6.4 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70509.1 - 7.4e-15 55.1 10.2 8.1e-09 35.9 1.0 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70509.1 - 3.7e-14 51.3 17.9 4.5e-05 22.9 0.1 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70509.1 - 9.6e-14 50.0 9.0 2.6e-06 26.8 0.1 5.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70509.1 - 1.1e-12 47.6 16.1 9.9e-07 28.6 1.4 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESS70509.1 - 8.8e-11 41.5 5.5 0.0019 18.5 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESS70509.1 - 8e-10 38.9 14.4 8.3e-07 29.2 2.3 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70509.1 - 5.2e-09 35.9 14.1 0.00012 22.3 0.2 4.5 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS70509.1 - 5.2e-09 35.6 13.5 0.0049 16.9 0.1 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS70509.1 - 1.1e-05 25.5 9.0 0.00026 21.0 2.4 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 ESS70509.1 - 0.00019 21.2 6.7 0.043 13.7 0.1 4.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70509.1 - 0.00075 19.3 7.8 0.025 14.4 0.2 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESS70509.1 - 0.049 13.7 0.5 4.3 7.5 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESS70509.1 - 6.7 6.0 10.1 23 4.3 0.0 4.2 5 0 0 5 5 5 0 SHNi-TPR Pkinase PF00069.20 ESS70510.1 - 2.5e-32 112.0 0.0 3.4e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70510.1 - 2.6e-16 59.4 0.0 2.1e-15 56.4 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESS70510.1 - 0.021 13.6 0.2 0.029 13.1 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase YabP PF07873.6 ESS70510.1 - 0.12 11.9 0.0 0.35 10.4 0.0 1.7 2 0 0 2 2 2 0 YabP family Kinase-like PF14531.1 ESS70510.1 - 0.18 10.7 0.1 1.4 7.8 0.0 2.0 2 0 0 2 2 2 0 Kinase-like AA_permease_2 PF13520.1 ESS70511.1 - 2.3e-16 59.3 23.2 4e-16 58.5 16.2 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESS70511.1 - 7.8e-09 34.3 19.9 1.8e-08 33.1 13.2 1.7 1 1 1 2 2 2 1 Amino acid permease Tex_N PF09371.5 ESS70513.1 - 5.9e-45 152.9 0.6 1.5e-44 151.6 0.4 1.7 1 0 0 1 1 1 1 Tex-like protein N-terminal domain HHH_3 PF12836.2 ESS70513.1 - 6.7e-08 32.3 0.3 2.2e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif YqgF PF14639.1 ESS70513.1 - 1.1e-07 31.4 0.1 6.9e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 S1 PF00575.18 ESS70513.1 - 0.0042 17.1 1.8 0.0043 17.1 0.2 1.8 2 0 0 2 2 2 1 S1 RNA binding domain HHH_7 PF14635.1 ESS70513.1 - 0.069 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Nucleoside_tran PF01733.13 ESS70514.1 - 7.7e-31 107.3 5.1 7.7e-31 107.3 3.5 1.9 2 0 0 2 2 2 1 Nucleoside transporter DUF4407 PF14362.1 ESS70515.1 - 0.052 12.4 8.0 0.068 12.1 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.6 ESS70515.1 - 0.09 11.4 1.9 0.12 10.9 1.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein IFT57 PF10498.4 ESS70515.1 - 0.35 9.5 2.9 0.48 9.1 2.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESS70515.1 - 1.2 8.0 4.3 1.7 7.4 3.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 YlqD PF11068.3 ESS70515.1 - 2.1 8.4 5.0 3.4 7.7 3.5 1.3 1 0 0 1 1 1 0 YlqD protein Carboxyl_trans PF01039.17 ESS70517.1 - 7.5e-148 492.9 0.0 9.7e-148 492.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 ESS70517.1 - 2.4e-06 26.9 0.1 0.0026 16.9 0.0 2.2 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) RRM_6 PF14259.1 ESS70519.1 - 1.6e-05 24.8 0.0 0.00046 20.1 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESS70519.1 - 6.2e-05 22.5 0.0 0.001 18.6 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M17 PF00883.16 ESS70522.1 - 7.2e-90 301.0 0.0 1e-89 300.5 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain GVQW PF13900.1 ESS70523.1 - 0.19 11.7 0.2 0.19 11.7 0.1 2.2 2 1 0 2 2 2 0 Putative binding domain MFS_1 PF07690.11 ESS70525.1 - 2.1e-13 49.7 37.3 9.7e-09 34.3 14.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESS70525.1 - 4.6e-10 39.1 17.0 4.6e-10 39.1 11.8 2.3 2 1 0 2 2 2 1 Nodulin-like DUF3278 PF11683.3 ESS70525.1 - 0.1 12.5 0.2 0.1 12.5 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3278) PgaD PF13994.1 ESS70525.1 - 1.9 7.9 7.9 0.3 10.5 0.8 2.5 2 0 0 2 2 2 0 PgaD-like protein MFS_1 PF07690.11 ESS70526.1 - 1.9e-18 66.3 36.3 4e-18 65.2 9.2 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESS70526.1 - 3.9e-06 26.3 17.5 3.9e-06 26.3 12.1 2.9 2 2 0 2 2 2 1 Nodulin-like ArsA_ATPase PF02374.10 ESS70527.1 - 4.9e-96 321.3 0.0 7e-96 320.8 0.0 1.2 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 ESS70527.1 - 3.4e-14 52.6 1.5 6.4e-13 48.5 1.0 2.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.1 ESS70527.1 - 3.1e-05 23.4 0.2 0.00013 21.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_31 PF13614.1 ESS70527.1 - 7.3e-05 22.7 0.0 0.0063 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.17 ESS70527.1 - 0.0079 15.6 0.2 1.2 8.5 0.2 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NB-ARC PF00931.17 ESS70527.1 - 0.046 12.5 0.0 0.084 11.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain CryBP1 PF07029.6 ESS70527.1 - 0.053 13.2 0.5 0.081 12.6 0.3 1.3 1 0 0 1 1 1 0 CryBP1 protein AAA_19 PF13245.1 ESS70527.1 - 0.089 12.5 0.1 0.25 11.1 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain Fer4_NifH PF00142.13 ESS70527.1 - 0.092 11.9 0.0 0.28 10.3 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PfUIS3 PF11567.3 ESS70528.1 - 0.094 12.8 0.9 1 9.5 0.0 2.4 1 1 1 2 2 2 0 Plasmodium falciparum UIS3 membrane protein Tmemb_cc2 PF10267.4 ESS70528.1 - 2.7 6.4 28.0 0.013 14.0 6.0 3.1 2 1 1 3 3 3 0 Predicted transmembrane and coiled-coil 2 protein DUF641 PF04859.7 ESS70528.1 - 5.2 6.8 22.8 0.034 13.8 1.4 3.9 2 1 1 4 4 4 0 Plant protein of unknown function (DUF641) Allexi_40kDa PF05549.6 ESS70528.1 - 5.2 6.2 14.1 6 6.0 0.4 3.0 2 1 2 4 4 4 0 Allexivirus 40kDa protein Peptidase_C11 PF03415.9 ESS70529.1 - 1.3e-08 34.2 0.1 1.9e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 Clostripain family SR-25 PF10500.4 ESS70529.1 - 2.1 7.7 6.5 4 6.8 0.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ribosomal_S21e PF01249.13 ESS70532.1 - 1.7e-30 104.8 0.1 2.5e-30 104.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S21e COX6B PF02297.12 ESS70533.1 - 0.02 14.9 3.0 0.02 14.9 2.1 2.7 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb DUF4475 PF14753.1 ESS70533.1 - 0.26 10.7 9.1 0.4 10.1 6.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4475) Pet191_N PF10203.4 ESS70533.1 - 1.5 8.9 7.0 0.8 9.7 0.6 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.8 ESS70533.1 - 3.2 7.7 11.4 15 5.6 0.0 3.8 4 0 0 4 4 4 0 CHCH domain UPF0203 PF05254.7 ESS70533.1 - 9.1 6.2 12.5 26 4.7 2.4 3.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0203) FHA PF00498.21 ESS70534.1 - 1e-05 25.5 0.0 2.9e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 FHA domain EF-hand_6 PF13405.1 ESS70536.1 - 5.6e-12 44.4 10.9 0.051 13.4 0.2 7.2 7 0 0 7 7 7 5 EF-hand domain EF-hand_7 PF13499.1 ESS70536.1 - 2.5e-08 33.9 6.3 0.075 13.1 0.3 6.3 5 2 1 6 6 6 4 EF-hand domain pair EF-hand_8 PF13833.1 ESS70536.1 - 2.7e-06 26.8 0.1 0.21 11.2 0.0 5.2 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.27 ESS70536.1 - 4.6e-06 25.5 0.0 2.9 7.4 0.0 5.5 6 0 0 6 6 6 2 EF hand DUF3037 PF11236.3 ESS70536.1 - 0.28 11.2 2.9 41 4.2 0.0 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF3037) Serinc PF03348.10 ESS70537.1 - 5.6e-54 183.4 30.1 1.1e-39 136.3 12.4 2.0 1 1 1 2 2 2 2 Serine incorporator (Serinc) DUF3552 PF12072.3 ESS70538.1 - 0.00058 19.1 21.5 0.00058 19.1 14.9 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) Jnk-SapK_ap_N PF09744.4 ESS70538.1 - 0.24 11.4 15.9 0.43 10.5 11.0 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 LMBR1 PF04791.11 ESS70538.1 - 0.31 9.5 2.1 0.45 9.0 1.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.4 ESS70538.1 - 1 8.2 19.9 1.7 7.4 13.8 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Borrelia_P83 PF05262.6 ESS70538.1 - 1.3 7.2 15.9 2.4 6.3 11.0 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein Spc7 PF08317.6 ESS70538.1 - 1.9 7.0 19.1 3.7 6.1 13.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.4 ESS70538.1 - 6.9 4.8 27.9 13 3.9 19.3 1.3 1 0 0 1 1 1 0 Transmembrane protein Tnp_P_element PF12017.3 ESS70539.1 - 0.31 10.2 1.7 0.57 9.3 1.2 1.4 1 0 0 1 1 1 0 Transposase protein PBP1_TM PF14812.1 ESS70539.1 - 0.87 9.9 0.0 0.87 9.9 0.0 4.4 4 1 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Abhydrolase_6 PF12697.2 ESS70540.1 - 3.2e-15 56.6 0.0 4.6e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS70540.1 - 2.3e-08 33.8 0.0 4.6e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS70540.1 - 1.1e-05 25.1 0.0 3.3e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESS70540.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase FAD_binding_9 PF08021.6 ESS70541.1 - 0.19 11.7 4.3 0.65 9.9 0.7 2.6 2 1 0 2 2 2 0 Siderophore-interacting FAD-binding domain Acetyltransf_13 PF13880.1 ESS70542.1 - 0.044 13.5 0.0 0.084 12.6 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase HEAT PF02985.17 ESS70543.1 - 8e-05 22.3 9.4 0.37 11.0 0.0 5.8 5 0 0 5 5 5 2 HEAT repeat Cohesin_HEAT PF12765.2 ESS70543.1 - 0.064 13.2 1.8 2.4 8.2 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.1 ESS70543.1 - 0.11 12.7 0.1 0.028 14.6 1.1 4.9 5 1 1 6 6 6 0 HEAT repeats HEAT_EZ PF13513.1 ESS70543.1 - 1.6 9.2 7.2 4.5 7.8 0.2 4.9 4 0 0 4 4 4 0 HEAT-like repeat MIF4G PF02854.14 ESS70544.1 - 4.6e-12 45.7 0.0 7.2e-07 28.8 0.0 3.0 3 0 0 3 3 3 2 MIF4G domain SDA1 PF05285.7 ESS70544.1 - 0.0013 18.0 20.7 0.0013 18.0 14.3 3.0 3 0 0 3 3 3 1 SDA1 RRN3 PF05327.6 ESS70544.1 - 5.8 4.8 12.2 13 3.6 8.5 1.6 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.6 ESS70544.1 - 8.8 5.7 26.3 8.2 5.8 16.8 2.0 2 0 0 2 2 2 0 PPP4R2 Kinesin PF00225.18 ESS70545.1 - 3e-92 308.8 0.0 6.7e-92 307.7 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain DEAD PF00270.24 ESS70545.1 - 0.05 13.0 0.0 0.14 11.6 0.0 1.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase START PF01852.14 ESS70546.1 - 5.8e-20 71.4 0.0 9.3e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 START domain DUF3074 PF11274.3 ESS70546.1 - 0.074 12.6 0.1 0.38 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3074) Herpes_UL32 PF06070.6 ESS70547.1 - 0.16 10.4 2.6 0.18 10.2 1.8 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 LRR_4 PF12799.2 ESS70548.1 - 2.1e-20 71.9 17.7 0.0055 16.2 0.0 9.3 7 2 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESS70548.1 - 3.7e-19 66.6 18.0 3 8.1 0.4 14.1 15 1 1 16 16 16 6 Leucine Rich repeat LRR_1 PF00560.28 ESS70548.1 - 5.7e-13 46.9 15.7 6.3 7.2 0.1 13.5 16 0 0 16 16 16 3 Leucine Rich Repeat LRR_8 PF13855.1 ESS70548.1 - 6.4e-09 35.4 22.9 0.02 14.6 1.2 9.5 8 2 2 10 10 10 5 Leucine rich repeat LRR_7 PF13504.1 ESS70548.1 - 1.5e-05 24.3 23.7 29 5.4 0.1 12.4 15 0 0 15 15 15 0 Leucine rich repeat Myc_N PF01056.13 ESS70548.1 - 0.071 12.2 0.8 0.12 11.5 0.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Rotamase_2 PF13145.1 ESS70548.1 - 0.21 12.2 1.7 0.65 10.6 1.2 1.8 1 0 0 1 1 1 0 PPIC-type PPIASE domain AAA PF00004.24 ESS70549.1 - 2.5e-41 140.9 0.0 1e-40 139.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 ESS70549.1 - 1e-05 25.0 0.0 3.2e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.9 ESS70549.1 - 1.1e-05 25.4 0.0 3.1e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESS70549.1 - 4.1e-05 23.6 1.0 0.00036 20.5 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 ESS70549.1 - 9.2e-05 22.1 0.0 0.0006 19.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESS70549.1 - 0.0001 22.4 0.0 0.0031 17.6 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESS70549.1 - 0.0014 18.3 0.5 0.021 14.5 0.0 2.9 3 0 0 3 3 3 1 Part of AAA domain AAA_33 PF13671.1 ESS70549.1 - 0.003 17.4 0.0 0.008 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESS70549.1 - 0.0041 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESS70549.1 - 0.0048 17.7 0.1 0.027 15.3 0.0 2.4 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 ESS70549.1 - 0.009 15.1 0.1 0.046 12.8 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 ESS70549.1 - 0.0096 14.9 0.0 0.021 13.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESS70549.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESS70549.1 - 0.011 14.4 0.0 0.019 13.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus NACHT PF05729.7 ESS70549.1 - 0.012 15.2 0.1 0.081 12.5 0.1 2.2 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 ESS70549.1 - 0.023 15.0 0.3 0.093 13.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 ESS70549.1 - 0.03 13.7 0.2 0.15 11.4 0.1 2.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESS70549.1 - 0.042 14.0 0.0 0.094 12.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Bromodomain PF00439.20 ESS70549.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Bromodomain Sigma54_activ_2 PF14532.1 ESS70549.1 - 0.058 13.4 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.10 ESS70549.1 - 0.067 13.0 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.22 ESS70549.1 - 0.072 13.3 0.0 0.33 11.2 0.0 2.2 2 0 0 2 2 1 0 ABC transporter PhoH PF02562.11 ESS70549.1 - 0.087 12.0 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF1294 PF06961.8 ESS70549.1 - 0.12 12.3 0.2 0.36 10.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) PUB PF09409.5 ESS70550.1 - 1.4e-34 117.7 0.0 2.4e-17 62.4 0.0 2.2 2 0 0 2 2 2 2 PUB domain SHOCT PF09851.4 ESS70550.1 - 5.4e-07 28.8 0.4 1.3e-06 27.6 0.3 1.7 1 0 0 1 1 1 1 Short C-terminal domain HrpE PF06188.7 ESS70551.1 - 6 6.5 10.7 27 4.4 7.4 1.9 1 1 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E zf-HIT PF04438.11 ESS70553.1 - 6.8e-06 25.6 9.8 1.3e-05 24.7 6.8 1.4 1 0 0 1 1 1 1 HIT zinc finger SR-25 PF10500.4 ESS70553.1 - 0.0086 15.5 1.9 0.011 15.1 1.3 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein zf-MYND PF01753.13 ESS70553.1 - 0.22 11.4 9.0 0.43 10.4 6.2 1.5 1 0 0 1 1 1 0 MYND finger Adaptin_N PF01602.15 ESS70554.1 - 5.9e-95 318.5 0.2 7.6e-95 318.1 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESS70554.1 - 6.5e-09 35.9 11.2 0.14 12.4 0.0 6.0 4 2 1 6 6 6 3 HEAT repeats Cnd1 PF12717.2 ESS70554.1 - 3.5e-07 30.2 0.3 5.9e-06 26.2 0.0 2.9 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 ESS70554.1 - 9.9e-05 22.1 8.7 0.28 11.3 0.0 6.3 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.1 ESS70554.1 - 0.00019 21.8 9.5 0.092 13.2 0.0 6.2 7 1 1 8 8 8 2 HEAT-like repeat CLASP_N PF12348.3 ESS70554.1 - 0.0088 15.4 0.1 3.2 7.0 0.0 2.5 2 1 1 3 3 3 3 CLASP N terminal PEP-utilizers_C PF02896.13 ESS70555.1 - 7.1e-66 222.0 0.5 1.2e-65 221.2 0.4 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.14 ESS70555.1 - 2.2e-62 211.0 0.0 4.7e-62 209.9 0.0 1.5 1 0 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.18 ESS70555.1 - 7.9e-23 79.8 0.1 1.8e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HTH_11 PF08279.7 ESS70555.1 - 0.026 14.1 0.0 0.19 11.4 0.0 2.4 2 0 0 2 2 2 0 HTH domain HTH_24 PF13412.1 ESS70555.1 - 0.04 13.3 0.1 0.094 12.1 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Exo_endo_phos PF03372.18 ESS70556.1 - 4.7e-09 36.5 0.0 8.9e-09 35.6 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.17 ESS70558.1 - 0.0025 17.3 0.0 0.35 10.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDE8 PF08629.5 ESS70558.1 - 0.0071 16.1 0.8 0.84 9.4 0.1 2.6 2 0 0 2 2 2 2 PDE8 phosphodiesterase RRM_6 PF14259.1 ESS70558.1 - 0.057 13.4 0.0 0.78 9.7 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) REV PF00424.13 ESS70559.1 - 0.25 11.2 2.4 0.36 10.7 1.6 1.2 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) SecY PF00344.15 ESS70560.1 - 6.3e-85 285.1 12.0 7.7e-85 284.8 8.3 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 ESS70560.1 - 7e-17 60.6 0.1 1.6e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Plug domain of Sec61p zf-DHHC PF01529.15 ESS70562.1 - 2.3e-29 102.0 5.4 2.3e-29 102.0 3.7 1.8 1 1 1 2 2 2 1 DHHC palmitoyltransferase PGG PF13962.1 ESS70562.1 - 0.029 13.9 0.7 0.029 13.9 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF2632 PF10943.3 ESS70562.1 - 0.082 12.4 0.2 0.082 12.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2632) p450 PF00067.17 ESS70563.1 - 2.5e-68 230.6 0.0 3e-68 230.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 eIF3_subunit PF08597.5 ESS70563.1 - 0.13 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit MORN PF02493.15 ESS70564.1 - 5.7e-22 76.0 22.2 9.3e-06 25.0 0.0 6.9 6 0 0 6 6 6 6 MORN repeat WD40 PF00400.27 ESS70565.1 - 1.7e-20 72.0 14.6 3.8e-07 29.7 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat Sec16_C PF12931.2 ESS70565.1 - 2.4e-08 34.0 0.0 7.1e-08 32.5 0.0 1.7 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 GTP_EFTU PF00009.22 ESS70567.1 - 3.1e-43 147.4 0.0 1.9e-42 144.8 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESS70567.1 - 3.2e-18 65.7 0.2 9.8e-18 64.1 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.18 ESS70567.1 - 9.7e-05 22.3 0.0 0.00038 20.3 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESS70567.1 - 0.00073 19.6 0.1 0.012 15.6 0.0 2.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 G-alpha PF00503.15 ESS70567.1 - 0.061 12.0 0.9 0.093 11.4 0.6 1.2 1 0 0 1 1 1 0 G-protein alpha subunit 60KD_IMP PF02096.15 ESS70568.1 - 2e-29 102.6 0.3 2.6e-29 102.3 0.2 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein DUF4375 PF14300.1 ESS70568.1 - 0.066 13.2 0.9 0.15 12.0 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) Solute_trans_a PF03619.11 ESS70569.1 - 5.9e-88 294.7 11.8 7.5e-88 294.4 8.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Prok-RING_2 PF14445.1 ESS70569.1 - 0.013 15.4 0.3 0.031 14.2 0.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 DUF2207 PF09972.4 ESS70570.1 - 0.49 8.9 4.1 0.64 8.5 2.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mito_fiss_reg PF05308.6 ESS70570.1 - 6 6.1 7.0 10 5.4 4.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator ABC2_membrane_3 PF12698.2 ESS70572.1 - 1e-57 195.7 51.2 1.3e-41 142.7 12.2 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.22 ESS70572.1 - 2.5e-51 173.5 0.0 5.9e-25 88.1 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 ESS70572.1 - 1.4e-20 74.4 0.3 1.5e-06 28.3 0.0 4.6 3 1 1 4 4 4 3 AAA domain AAA_29 PF13555.1 ESS70572.1 - 2.6e-05 23.6 0.6 0.031 13.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 ESS70572.1 - 7e-05 22.1 0.0 2.8 7.1 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESS70572.1 - 7.4e-05 23.1 0.5 0.47 10.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 ESS70572.1 - 0.00022 20.4 0.2 0.019 14.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRP54 PF00448.17 ESS70572.1 - 0.00032 20.1 0.3 0.033 13.6 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_15 PF13175.1 ESS70572.1 - 0.00037 19.6 0.0 1.3 7.9 0.0 3.5 4 0 0 4 4 4 1 AAA ATPase domain SbcCD_C PF13558.1 ESS70572.1 - 0.0013 18.5 0.0 0.57 10.1 0.0 2.8 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 ESS70572.1 - 0.0024 17.3 0.6 2.7 7.3 0.1 2.8 3 0 0 3 3 3 2 AAA-like domain AAA_25 PF13481.1 ESS70572.1 - 0.023 14.0 0.1 7.5 5.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESS70572.1 - 0.043 12.9 0.1 16 4.5 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin AAA_30 PF13604.1 ESS70572.1 - 0.072 12.6 0.0 0.92 9.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESS70572.1 - 0.14 11.8 0.1 0.71 9.5 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 ESS70572.1 - 0.16 12.0 0.1 32 4.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESS70572.1 - 0.21 11.0 0.9 2.4 7.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 ESS70572.1 - 0.31 11.0 0.1 6.3 6.7 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_13 PF13166.1 ESS70572.1 - 1.3 7.4 0.3 18 3.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 ESS70572.1 - 2.7 7.7 3.6 1.9 8.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF87 DUF1049 PF06305.6 ESS70572.1 - 5.6 6.5 10.1 0.35 10.3 0.8 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) TatD_DNase PF01026.16 ESS70574.1 - 2.2e-42 145.0 0.0 2.6e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase 4HBT_3 PF13622.1 ESS70575.1 - 1.1e-26 94.1 0.1 1.5e-26 93.7 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 ESS70575.1 - 1.8e-17 63.2 0.0 1.7e-15 56.7 0.0 2.8 2 1 1 3 3 3 1 Acyl-CoA thioesterase HEAT PF02985.17 ESS70577.1 - 8.6e-09 34.7 5.5 0.52 10.5 0.1 6.0 5 0 0 5 5 5 4 HEAT repeat Arm PF00514.18 ESS70577.1 - 1.2e-08 34.5 1.7 0.13 12.1 0.0 5.6 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESS70577.1 - 2.7e-08 33.9 8.7 0.0023 18.1 0.1 4.2 3 1 1 4 4 4 2 HEAT repeats Arm_2 PF04826.8 ESS70577.1 - 0.0031 16.6 0.0 0.15 11.1 0.0 2.2 2 0 0 2 2 2 1 Armadillo-like HEAT_EZ PF13513.1 ESS70577.1 - 0.0051 17.2 8.9 6.5 7.3 0.0 5.1 4 2 1 5 5 5 2 HEAT-like repeat Tmemb_14 PF03647.8 ESS70578.1 - 0.46 10.8 7.2 2 8.8 0.4 3.3 3 0 0 3 3 3 0 Transmembrane proteins 14C zf-HC2 PF13490.1 ESS70579.1 - 0.091 12.7 1.7 0.27 11.2 1.2 1.8 1 0 0 1 1 1 0 Putative zinc-finger DUF4609 PF15382.1 ESS70580.1 - 0.066 12.9 0.1 0.67 9.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4609) DUF3857 PF12969.2 ESS70580.1 - 0.08 12.5 0.1 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3857) PapD-like PF14874.1 ESS70581.1 - 4.1e-44 148.6 0.6 9.1e-44 147.5 0.4 1.6 1 0 0 1 1 1 1 Flagellar-associated PapD-like XAP5 PF04921.9 ESS70581.1 - 1.2 8.6 4.7 2.1 7.8 3.2 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator Nodulin-like PF06813.8 ESS70582.1 - 2.7e-17 62.8 15.5 2.7e-17 62.8 10.7 2.4 2 1 0 2 2 2 1 Nodulin-like MFS_1 PF07690.11 ESS70582.1 - 4.3e-10 38.8 25.8 1e-05 24.4 14.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Pax2_C PF12403.3 ESS70583.1 - 0.075 12.6 0.1 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 Paired-box protein 2 C terminal Ribosomal_L4 PF00573.17 ESS70584.1 - 6.6e-09 35.4 0.0 1.6e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family TruD PF01142.13 ESS70585.1 - 3.6e-06 25.9 0.0 2.6e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 tRNA pseudouridine synthase D (TruD) DNA_pol_delta_4 PF04081.8 ESS70585.1 - 0.059 13.6 0.0 3.4 7.9 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase delta, subunit 4 SH3_1 PF00018.23 ESS70586.1 - 2.6e-08 33.1 0.0 4.9e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESS70586.1 - 2.5e-07 30.1 0.0 6.1e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 ESS70586.1 - 4.6e-05 22.8 0.0 8.4e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Surfac_D-trimer PF09006.6 ESS70586.1 - 0.14 11.9 1.2 1.1 9.0 0.3 2.5 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation ArsC PF03960.10 ESS70586.1 - 1.2 9.2 6.7 1.4 8.9 2.0 2.8 2 2 0 2 2 2 0 ArsC family VIT1 PF01988.14 ESS70586.1 - 1.5 8.2 4.6 2.9 7.3 3.2 1.4 1 0 0 1 1 1 0 VIT family PI-PLC-X PF00388.14 ESS70587.1 - 1.2e-62 209.6 0.0 1.9e-62 209.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_6 PF13405.1 ESS70587.1 - 1.5e-05 24.4 0.0 0.042 13.7 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 ESS70587.1 - 0.00012 21.0 0.4 0.0029 16.8 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_like PF09279.6 ESS70587.1 - 0.0012 18.8 0.0 0.0078 16.2 0.0 2.5 2 1 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.1 ESS70587.1 - 0.044 13.9 0.0 0.23 11.6 0.0 2.2 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 ESS70587.1 - 0.13 11.6 0.5 0.4 10.1 0.0 2.1 2 0 0 2 2 2 0 EF hand PI-PLC-Y PF00387.14 ESS70588.1 - 6.5e-31 106.7 0.4 9.1e-31 106.2 0.3 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 ESS70588.1 - 1.2e-12 47.4 0.0 1.9e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 C2 domain Cyt-b5 PF00173.23 ESS70589.1 - 2.9e-21 75.0 0.0 3.8e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ank_2 PF12796.2 ESS70590.1 - 3.3e-31 107.4 0.3 7.2e-14 51.9 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESS70590.1 - 3.1e-27 94.4 3.5 3.1e-08 33.9 0.0 5.0 1 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 ESS70590.1 - 2.4e-23 80.6 1.9 6.1e-06 25.7 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 ESS70590.1 - 3.9e-22 77.7 4.4 8.7e-09 35.3 0.2 4.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS70590.1 - 2.6e-16 58.0 0.8 0.0032 17.5 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeat SRP54_N PF02881.14 ESS70590.1 - 0.15 12.2 0.4 11 6.1 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain MIT PF04212.13 ESS70591.1 - 0.0038 17.0 0.1 0.0056 16.5 0.1 1.2 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Ribosomal_L24e PF01246.15 ESS70592.1 - 1.9e-31 107.7 1.7 6.1e-31 106.1 1.2 1.9 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FCS PF06467.9 ESS70592.1 - 0.11 12.1 5.6 0.19 11.3 3.9 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-ribbon_3 PF13248.1 ESS70592.1 - 0.3 10.3 2.2 0.53 9.5 1.6 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Cid2 PF09774.4 ESS70592.1 - 1.5 8.8 11.2 0.062 13.3 0.7 2.1 1 1 1 2 2 2 0 Caffeine-induced death protein 2 DUF2116 PF09889.4 ESS70592.1 - 3.7 7.4 13.5 2.9 7.7 3.5 3.3 2 1 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF3042 PF11240.3 ESS70592.1 - 8.1 6.3 6.8 4.6 7.1 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) 3-PAP PF12578.3 ESS70593.1 - 1.9e-33 115.3 2.8 2.3e-33 115.0 2.0 1.1 1 0 0 1 1 1 1 Myotubularin-associated protein Dzip-like_N PF13815.1 ESS70593.1 - 1.2e-07 31.5 1.0 1.2e-07 31.5 0.7 1.7 1 1 1 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal Bcr-Abl_Oligo PF09036.5 ESS70593.1 - 0.016 15.1 0.8 0.03 14.2 0.6 1.5 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain XPA_C PF05181.7 ESS70593.1 - 0.03 13.8 0.3 0.095 12.2 0.1 1.9 2 0 0 2 2 2 0 XPA protein C-terminus Ribosomal_S7 PF00177.16 ESS70594.1 - 3.8e-38 130.3 0.3 4.6e-38 130.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Sec20 PF03908.8 ESS70595.1 - 6.8e-08 32.1 0.8 1.4e-07 31.1 0.5 1.5 1 0 0 1 1 1 1 Sec20 PUA PF01472.15 ESS70597.1 - 7.6e-17 60.8 0.1 1.3e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 PUA domain Ras PF00071.17 ESS70598.1 - 3.8e-49 166.1 0.1 4.4e-49 165.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESS70598.1 - 1.1e-16 61.4 0.0 1.4e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS70598.1 - 4.3e-06 26.0 0.0 5.5e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESS70598.1 - 3.4e-05 23.3 0.2 5.8e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESS70598.1 - 0.00034 20.5 0.0 0.00056 19.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase IncA PF04156.9 ESS70599.1 - 0.00069 19.2 2.9 0.00081 19.0 2.0 1.2 1 0 0 1 1 1 1 IncA protein AKNA PF12443.3 ESS70599.1 - 0.01 15.8 0.8 0.018 15.0 0.6 1.5 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF3972 PF13118.1 ESS70599.1 - 0.032 14.3 1.2 0.044 13.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) BLOC1_2 PF10046.4 ESS70599.1 - 0.039 14.1 1.8 0.072 13.2 1.0 1.5 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nup54 PF13874.1 ESS70599.1 - 0.041 13.5 3.8 0.068 12.8 2.6 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF4599 PF15371.1 ESS70599.1 - 0.07 13.1 4.0 0.092 12.8 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4599) NYD-SP28_assoc PF14775.1 ESS70599.1 - 0.23 11.2 0.3 0.23 11.2 0.2 2.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain Med21 PF11221.3 ESS70599.1 - 0.58 10.1 4.3 0.36 10.7 1.6 1.6 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF904 PF06005.7 ESS70599.1 - 4.1 7.7 9.5 20 5.5 6.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Syntaxin-6_N PF09177.6 ESS70600.1 - 0.13 12.7 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal TcpE PF12648.2 ESS70601.1 - 0.048 13.8 0.5 0.08 13.0 0.4 1.3 1 0 0 1 1 1 0 TcpE family PA PF02225.17 ESS70602.1 - 9.9e-09 34.8 0.1 1.4e-08 34.3 0.1 1.2 1 0 0 1 1 1 1 PA domain Ribosomal_S8 PF00410.14 ESS70603.1 - 3e-23 82.0 0.0 4.2e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Skp1 PF01466.14 ESS70604.1 - 3.5e-34 116.6 0.8 5.3e-34 116.1 0.5 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 ESS70604.1 - 5.6e-14 51.9 0.0 2e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain PK PF00224.16 ESS70678.1 - 3.5e-163 542.2 0.3 4.6e-163 541.8 0.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 ESS70678.1 - 9.5e-27 92.8 0.5 3.3e-25 87.9 0.0 3.0 3 0 0 3 3 3 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 ESS70678.1 - 5e-05 22.3 0.6 0.00024 20.0 0.4 1.9 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Syntaxin-18_N PF10496.4 ESS70679.1 - 0.022 14.5 0.6 0.022 14.5 0.4 3.2 3 1 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus DUF1664 PF07889.7 ESS70679.1 - 0.26 11.0 0.1 0.26 11.0 0.1 4.1 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) WD40 PF00400.27 ESS70680.1 - 3.9e-38 127.9 5.5 1.1e-07 31.4 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESS70680.1 - 0.00017 21.0 0.0 0.41 10.1 0.0 3.4 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 ESS70680.1 - 0.044 11.6 0.6 0.89 7.2 0.0 2.0 2 0 0 2 2 2 0 IKI3 family Malectin_like PF12819.2 ESS70681.1 - 0.0014 17.8 1.4 0.012 14.7 0.0 2.1 2 0 0 2 2 2 2 Carbohydrate-binding protein of the ER SNARE PF05739.14 ESS70682.1 - 1e-14 53.9 0.6 1e-14 53.9 0.4 2.9 3 1 0 3 3 3 1 SNARE domain HsbA PF12296.3 ESS70682.1 - 0.028 14.2 1.2 0.061 13.1 0.2 2.1 2 0 0 2 2 2 0 Hydrophobic surface binding protein A DUF883 PF05957.8 ESS70682.1 - 0.056 13.8 0.3 0.056 13.8 0.2 3.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF1178 PF06676.6 ESS70682.1 - 0.15 12.2 3.1 0.25 11.5 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) Syntaxin PF00804.20 ESS70682.1 - 0.21 11.7 10.7 0.052 13.7 3.1 2.7 1 1 1 2 2 2 0 Syntaxin TMF_TATA_bd PF12325.3 ESS70682.1 - 0.39 10.4 13.2 1.1 9.0 0.7 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding SPX PF03105.14 ESS70682.1 - 0.96 9.1 5.6 1.4 8.6 3.9 1.3 1 0 0 1 1 1 0 SPX domain CENP-Q PF13094.1 ESS70682.1 - 1.1 9.2 15.8 0.38 10.7 6.3 2.6 1 1 2 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Syntaxin-6_N PF09177.6 ESS70682.1 - 2.4 8.6 7.9 0.73 10.2 0.6 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal OmpH PF03938.9 ESS70682.1 - 5.1 7.0 14.5 0.46 10.4 3.9 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) CRF PF00473.12 ESS70683.1 - 0.09 12.8 2.2 11 6.2 0.1 3.0 2 0 0 2 2 2 0 Corticotropin-releasing factor family WD40 PF00400.27 ESS70684.1 - 1.9e-10 40.1 14.0 0.0012 18.6 0.0 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat WD40 PF00400.27 ESS70685.1 - 3.5e-08 33.0 4.5 4e-05 23.3 0.2 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat NMT_C PF02799.10 ESS70686.1 - 6.1e-59 198.6 1.2 2.9e-38 131.1 0.5 2.7 3 0 0 3 3 3 2 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.14 ESS70686.1 - 7.2e-59 198.0 0.7 6.5e-33 113.6 0.0 2.3 2 0 0 2 2 2 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Adeno_terminal PF02459.10 ESS70686.1 - 0.021 12.9 0.1 0.033 12.3 0.1 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein TT_ORF1 PF02956.9 ESS70687.1 - 0.41 9.0 5.6 0.056 11.8 1.1 1.5 2 0 0 2 2 2 0 TT viral orf 1 NIF PF03031.13 ESS70688.1 - 6.9e-29 100.5 0.0 4.4e-27 94.6 0.0 2.4 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 ESS70688.1 - 0.0065 16.7 0.6 0.025 14.8 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Macoilin PF09726.4 ESS70688.1 - 7.6 4.6 13.5 0.34 9.1 3.0 2.1 2 0 0 2 2 2 0 Transmembrane protein Pkinase PF00069.20 ESS70690.1 - 1.6e-60 204.4 0.0 2.3e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70690.1 - 1.4e-30 106.2 0.0 2.1e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS70690.1 - 0.003 17.3 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESS70690.1 - 0.022 13.8 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESS70690.1 - 0.031 13.2 0.0 0.054 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Arm PF00514.18 ESS70692.1 - 4.7e-40 134.0 18.0 5e-10 38.8 0.0 12.5 12 0 0 12 12 12 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESS70692.1 - 1.3e-06 28.6 5.5 0.21 11.8 0.0 4.6 3 2 1 4 4 4 3 HEAT repeats HEAT PF02985.17 ESS70692.1 - 1.4e-05 24.7 1.3 0.021 14.8 0.0 4.3 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.1 ESS70692.1 - 5.7e-05 23.4 6.0 1.3 9.6 0.0 4.1 3 0 0 3 3 3 3 HEAT-like repeat Arm_2 PF04826.8 ESS70692.1 - 8e-05 21.8 2.2 0.0063 15.6 0.0 4.1 5 2 1 6 6 6 1 Armadillo-like Atx10homo_assoc PF09759.4 ESS70692.1 - 0.00031 20.4 2.3 12 5.6 0.0 5.1 5 1 1 6 6 6 1 Spinocerebellar ataxia type 10 protein domain E3_UbLigase_R4 PF13764.1 ESS70692.1 - 0.038 11.8 0.4 1.2 6.9 0.1 2.7 1 1 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 YcgR PF07317.7 ESS70692.1 - 0.084 12.6 0.0 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 Flagellar regulator YcgR RICTOR_V PF14668.1 ESS70692.1 - 0.18 11.7 2.0 3.5 7.6 0.1 3.8 5 1 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 DUF1843 PF08898.5 ESS70693.1 - 0.013 15.4 1.7 0.044 13.8 1.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) Utp14 PF04615.8 ESS70694.1 - 3.4e-70 237.1 79.3 1.5e-67 228.4 38.4 3.3 2 2 0 3 3 3 2 Utp14 protein LRR_9 PF14580.1 ESS70697.1 - 9.3e-23 80.6 0.9 7.2e-13 48.4 0.1 2.2 2 0 0 2 2 2 2 Leucine-rich repeat OmpH PF03938.9 ESS70697.1 - 0.0025 17.7 4.5 0.0042 17.0 3.1 1.4 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) LRR_1 PF00560.28 ESS70697.1 - 0.011 15.6 2.0 64 4.1 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.2 ESS70697.1 - 0.017 14.7 4.3 0.59 9.8 0.3 3.3 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70697.1 - 0.048 13.4 4.9 0.39 10.4 0.2 2.8 2 1 0 2 2 2 0 Leucine rich repeat FbpA PF05833.6 ESS70697.1 - 0.29 9.6 6.6 0.47 8.9 4.6 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HrpA_pilin PF09589.5 ESS70697.1 - 0.76 10.2 6.0 1.3 9.4 4.2 1.4 1 0 0 1 1 1 0 HrpA pilus formation protein HSP70 PF00012.15 ESS70698.1 - 1.2e-09 36.7 0.0 1.3e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein DUF3636 PF12331.3 ESS70699.1 - 0.039 13.5 0.3 0.1 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) DUF2400 PF09674.5 ESS70699.1 - 0.12 12.0 0.8 0.3 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) TORC_N PF12884.2 ESS70699.1 - 6.4 7.3 14.0 0.038 14.5 1.9 3.4 3 1 0 3 3 3 0 Transducer of regulated CREB activity, N terminus Rtt106 PF08512.7 ESS70700.1 - 3.2e-13 49.4 0.0 5.6e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Nop14 PF04147.7 ESS70700.1 - 6.7e-05 21.0 25.3 8.1e-05 20.7 17.6 1.1 1 0 0 1 1 1 1 Nop14-like family DUF3381 PF11861.3 ESS70700.1 - 0.0013 18.2 15.6 0.0026 17.3 10.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3381) Cwf_Cwc_15 PF04889.7 ESS70700.1 - 0.0052 16.5 30.1 0.0083 15.8 20.9 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 ESS70700.1 - 0.006 14.6 29.5 0.0094 14.0 20.4 1.3 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.7 ESS70700.1 - 0.026 13.8 29.8 0.037 13.3 20.6 1.2 1 0 0 1 1 1 0 SDA1 SSrecog PF03531.9 ESS70700.1 - 0.027 13.7 0.0 0.071 12.4 0.0 1.7 1 1 0 1 1 1 0 Structure-specific recognition protein (SSRP1) Nop53 PF07767.6 ESS70700.1 - 0.035 13.1 26.0 0.049 12.6 18.0 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2457 PF10446.4 ESS70700.1 - 0.038 12.7 44.7 0.023 13.4 29.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2457) YL1 PF05764.8 ESS70700.1 - 0.073 12.6 31.5 0.11 12.0 21.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein RNase_H2-Ydr279 PF09468.5 ESS70700.1 - 0.25 10.5 10.1 0.5 9.5 7.0 1.5 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) VID27 PF08553.5 ESS70700.1 - 0.32 9.1 14.9 0.44 8.7 10.3 1.2 1 0 0 1 1 1 0 VID27 cytoplasmic protein NOA36 PF06524.7 ESS70700.1 - 0.71 9.0 17.2 1.3 8.2 11.9 1.5 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.8 ESS70700.1 - 1.5 8.4 24.0 2.7 7.5 16.6 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF1510 PF07423.6 ESS70700.1 - 2.3 7.5 24.6 3.8 6.8 17.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3295 PF11702.3 ESS70700.1 - 2.8 6.8 18.0 0.54 9.1 9.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) CobT PF06213.7 ESS70700.1 - 3.4 6.7 26.7 5.8 5.9 18.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sporozoite_P67 PF05642.6 ESS70700.1 - 4 5.1 13.6 6 4.5 9.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Bd3614_N PF14442.1 ESS70700.1 - 5.2 7.0 11.7 9.5 6.1 8.1 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Astro_capsid PF03115.9 ESS70700.1 - 8.2 4.5 8.7 13 3.8 6.0 1.3 1 0 0 1 1 1 0 Astrovirus capsid protein precursor LRR_4 PF12799.2 ESS70702.1 - 7.4e-09 35.0 4.0 0.056 13.0 0.1 5.3 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70702.1 - 1.1e-05 25.0 5.9 0.5 10.1 1.2 4.4 3 2 1 4 4 4 3 Leucine rich repeat LRR_6 PF13516.1 ESS70702.1 - 0.0023 17.8 4.9 10 6.5 0.0 6.4 7 0 0 7 7 7 1 Leucine Rich repeat LRR_1 PF00560.28 ESS70702.1 - 0.013 15.4 9.7 4.6 7.6 0.1 6.1 5 1 1 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 ESS70702.1 - 0.31 11.4 12.6 7.5 7.2 0.1 6.5 7 0 0 7 7 7 0 Leucine rich repeat CENP-B_dimeris PF09026.5 ESS70703.1 - 0.89 9.8 5.5 21 5.4 0.5 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Pkinase PF00069.20 ESS70705.1 - 4.8e-72 242.2 0.6 1.7e-71 240.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70705.1 - 3.4e-51 173.8 0.0 7.6e-51 172.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70705.1 - 7.5e-08 31.6 0.0 7.5e-08 31.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like SSP160 PF06933.6 ESS70706.1 - 1 7.2 14.4 1.7 6.4 10.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 B9-C2 PF07162.6 ESS70707.1 - 5e-43 146.7 0.0 6.2e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein CIMR PF00878.13 ESS70708.1 - 0.14 11.9 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat LRR_4 PF12799.2 ESS70709.1 - 3e-13 49.0 6.4 0.0015 18.1 0.0 6.4 6 1 1 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70709.1 - 8.9e-09 34.9 9.8 0.00032 20.3 0.8 4.9 3 3 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 ESS70709.1 - 1.7e-05 24.1 10.9 0.023 14.6 0.1 5.8 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.1 ESS70709.1 - 0.0015 18.4 6.5 6.1 7.2 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich repeat LRR_7 PF13504.1 ESS70709.1 - 0.01 15.8 9.3 7 7.3 0.1 5.4 5 0 0 5 5 5 0 Leucine rich repeat Clathrin PF00637.15 ESS70710.1 - 8.4e-12 44.8 0.7 0.0014 18.2 0.0 5.7 5 1 1 6 6 6 3 Region in Clathrin and VPS WD40 PF00400.27 ESS70710.1 - 2.6e-07 30.2 0.8 0.081 12.8 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESS70710.1 - 3.5e-06 26.0 1.0 0.00026 19.9 0.0 3.3 3 1 0 3 3 3 1 Coatomer WD associated region TPR_19 PF14559.1 ESS70710.1 - 0.0002 21.6 2.7 0.72 10.2 0.0 5.6 4 2 1 5 5 5 1 Tetratricopeptide repeat Nic96 PF04097.9 ESS70710.1 - 0.005 15.0 1.7 0.034 12.2 0.0 3.1 4 0 0 4 4 4 1 Nup93/Nic96 UNC45-central PF11701.3 ESS70710.1 - 0.013 15.1 0.5 0.085 12.5 0.1 2.3 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central DUF1024 PF06260.7 ESS70710.1 - 0.026 14.6 0.1 1.9 8.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1024) ACDC PF14733.1 ESS70710.1 - 0.087 12.9 0.2 0.41 10.7 0.0 2.2 2 0 0 2 2 2 0 AP2-coincident C-terminal TPR_2 PF07719.12 ESS70710.1 - 0.15 12.0 7.5 68 3.7 0.1 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat RHD3 PF05879.7 ESS70716.1 - 1.2e-111 373.9 4.4 3.8e-100 335.9 1.2 3.0 2 1 0 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.18 ESS70716.1 - 0.00014 21.7 0.1 0.00031 20.5 0.0 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESS70716.1 - 0.00065 19.6 0.0 0.002 18.0 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESS70716.1 - 0.003 18.0 0.0 0.0087 16.5 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein AAA_28 PF13521.1 ESS70716.1 - 0.0089 16.0 0.1 0.039 13.9 0.1 2.1 1 0 0 1 1 1 1 AAA domain DUF1449 PF07290.6 ESS70716.1 - 0.017 14.4 0.2 0.03 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) ABC_tran PF00005.22 ESS70716.1 - 0.018 15.3 0.0 0.057 13.7 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Borrelia_REV PF03978.8 ESS70716.1 - 0.037 13.7 0.8 0.093 12.4 0.6 1.6 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Septin PF00735.13 ESS70716.1 - 0.088 11.8 0.9 0.33 9.9 0.0 2.2 2 0 0 2 2 2 0 Septin MitMem_reg PF13012.1 ESS70718.1 - 2.7e-20 72.5 0.1 2.7e-20 72.5 0.1 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 ESS70718.1 - 2.7e-19 69.0 0.1 5.5e-18 64.7 0.0 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TAN PF11640.3 ESS70718.1 - 0.0031 17.2 0.3 0.0061 16.2 0.2 1.5 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair OsmC PF02566.14 ESS70718.1 - 0.012 15.7 0.1 0.045 13.9 0.0 1.9 2 0 0 2 2 2 0 OsmC-like protein DUF1664 PF07889.7 ESS70718.1 - 0.85 9.4 3.6 0.69 9.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DEAD PF00270.24 ESS70719.1 - 4.1e-42 143.5 0.0 2.9e-41 140.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS70719.1 - 2e-27 94.8 0.1 7.7e-27 92.9 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 ESS70719.1 - 0.084 11.2 0.2 0.19 10.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) HWE_HK PF07536.9 ESS70721.1 - 0.038 14.4 0.0 0.086 13.2 0.0 1.6 1 0 0 1 1 1 0 HWE histidine kinase TPR_11 PF13414.1 ESS70722.1 - 4.6e-17 61.4 22.3 1.3e-09 37.5 0.1 6.6 5 1 1 6 6 6 4 TPR repeat TPR_8 PF13181.1 ESS70722.1 - 7e-06 25.4 2.4 0.0068 16.1 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70722.1 - 9.3e-06 25.1 27.4 0.0039 17.0 0.1 8.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70722.1 - 0.00027 20.8 29.5 0.0056 16.5 0.2 7.8 6 2 1 8 8 8 1 Tetratricopeptide repeat Apc3 PF12895.2 ESS70722.1 - 0.00042 20.3 7.4 0.002 18.1 0.2 3.8 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESS70722.1 - 0.00099 18.9 5.7 0.0023 17.7 0.1 4.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESS70722.1 - 0.059 13.7 12.9 0.21 11.9 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESS70722.1 - 0.059 12.9 0.1 0.059 12.9 0.1 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70722.1 - 0.091 13.4 36.0 2 9.2 0.1 7.8 4 3 1 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70722.1 - 0.47 11.2 0.0 0.47 11.2 0.0 7.2 7 3 2 9 9 9 0 Tetratricopeptide repeat Kinesin PF00225.18 ESS70723.1 - 4.6e-28 97.8 0.0 6.2e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain MORN PF02493.15 ESS70723.1 - 2.4e-18 64.6 35.0 0.00019 20.9 0.2 7.2 7 0 0 7 7 7 6 MORN repeat DUF1279 PF06916.8 ESS70724.1 - 0.00011 22.4 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) WW PF00397.21 ESS70724.1 - 0.00022 21.0 0.5 0.00044 20.0 0.3 1.5 1 0 0 1 1 1 1 WW domain Aldo_ket_red PF00248.16 ESS70725.1 - 1.1e-64 217.9 0.0 1.3e-64 217.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_6 PF13516.1 ESS70726.1 - 1.8e-10 39.8 32.8 0.18 11.9 0.1 10.4 12 0 0 12 12 12 4 Leucine Rich repeat LRR_4 PF12799.2 ESS70726.1 - 2.1e-09 36.7 24.9 0.062 12.9 0.2 8.3 5 2 4 9 9 9 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESS70726.1 - 0.00015 21.3 23.3 23 5.5 0.0 10.1 9 2 1 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.1 ESS70726.1 - 0.009 15.7 24.0 7.9 6.3 0.2 7.2 6 1 1 7 7 7 3 Leucine rich repeat Ycf1 PF05758.7 ESS70726.1 - 0.039 11.6 8.2 0.058 11.1 5.7 1.2 1 0 0 1 1 1 0 Ycf1 DUF4090 PF13319.1 ESS70726.1 - 0.067 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) Zip PF02535.17 ESS70726.1 - 0.14 11.1 1.9 0.25 10.3 1.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter NARP1 PF12569.3 ESS70726.1 - 1.2 7.8 18.7 1.9 7.1 13.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SDA1 PF05285.7 ESS70726.1 - 1.3 8.2 37.6 0.079 12.2 19.8 2.3 2 0 0 2 2 2 0 SDA1 Vfa1 PF08432.5 ESS70726.1 - 2.4 8.1 24.8 0.051 13.6 12.1 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CAF1A PF12253.3 ESS70727.1 - 0.026 14.6 0.0 0.072 13.2 0.0 1.7 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Brix PF04427.13 ESS70728.1 - 7.7e-36 123.5 0.0 1.1e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain SNARE PF05739.14 ESS70729.1 - 7.5e-11 41.5 6.7 2.2e-10 40.0 2.1 2.5 2 0 0 2 2 2 1 SNARE domain Mago_nashi PF02792.9 ESS70729.1 - 0.033 13.8 0.6 0.062 12.9 0.4 1.4 1 0 0 1 1 1 0 Mago nashi protein Fib_alpha PF08702.5 ESS70729.1 - 0.47 10.5 6.8 0.86 9.7 1.3 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.7 ESS70729.1 - 0.47 10.1 6.1 1 9.1 0.8 2.5 2 0 0 2 2 2 0 Laminin Domain II Tropomyosin_1 PF12718.2 ESS70729.1 - 0.52 10.1 15.2 0.84 9.4 5.4 2.6 2 1 0 2 2 2 0 Tropomyosin like DUF745 PF05335.8 ESS70729.1 - 0.58 9.6 5.8 0.24 10.8 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Syntaxin PF00804.20 ESS70729.1 - 4.9 7.3 11.8 9.1 6.5 0.1 3.3 2 2 1 3 3 3 0 Syntaxin Ctr PF04145.10 ESS70731.1 - 0.027 14.5 0.5 7.5 6.6 0.0 2.3 2 1 0 2 2 2 0 Ctr copper transporter family PCMT PF01135.14 ESS70731.1 - 0.063 12.7 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DnaJ PF00226.26 ESS70732.1 - 5.5e-20 70.8 1.1 1.9e-19 69.1 0.1 2.6 2 0 0 2 2 2 1 DnaJ domain Glyco_hydro_65N PF03636.10 ESS70733.1 - 0.073 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Ribosomal_60s PF00428.14 ESS70733.1 - 0.51 10.7 9.3 2 8.8 3.5 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DnaJ PF00226.26 ESS70733.1 - 1.7 8.4 15.3 0.48 10.1 3.2 3.6 2 1 0 2 2 2 0 DnaJ domain SseC PF04888.7 ESS70733.1 - 3 7.0 4.3 6.5 5.9 3.0 1.5 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Fibrillarin PF01269.12 ESS70734.1 - 3.8e-103 343.3 0.0 4.3e-103 343.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 ESS70734.1 - 3.8e-07 29.8 0.0 5.2e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit SNARE PF05739.14 ESS70735.1 - 1.5e-10 40.6 2.7 8.7e-10 38.1 0.8 2.3 2 0 0 2 2 2 1 SNARE domain Synaptobrevin PF00957.16 ESS70735.1 - 0.0097 15.4 0.2 0.018 14.6 0.1 1.5 1 0 0 1 1 1 1 Synaptobrevin DUF1206 PF06724.6 ESS70735.1 - 0.054 13.2 0.1 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) Use1 PF09753.4 ESS70735.1 - 0.12 11.8 1.6 0.1 12.0 0.2 1.5 2 0 0 2 2 2 0 Membrane fusion protein Use1 Rifin_STEVOR PF02009.11 ESS70735.1 - 0.12 11.9 1.0 0.14 11.8 0.1 1.5 2 0 0 2 2 2 0 Rifin/stevor family Rhabdo_glycop PF00974.13 ESS70735.1 - 0.13 10.4 0.1 0.18 9.9 0.1 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein WXG100 PF06013.7 ESS70735.1 - 0.96 9.4 3.3 14 5.7 0.1 2.8 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Pkinase PF00069.20 ESS70736.1 - 4.6e-55 186.5 0.0 7.8e-55 185.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70736.1 - 2.5e-25 89.0 0.0 3.9e-20 72.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase CAP_GLY PF01302.20 ESS70736.1 - 1.8e-16 59.5 0.9 3.5e-16 58.6 0.7 1.5 1 0 0 1 1 1 1 CAP-Gly domain Kinase-like PF14531.1 ESS70736.1 - 4.3e-06 25.8 0.0 0.0084 15.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like DUF904 PF06005.7 ESS70736.1 - 0.042 14.1 0.9 0.085 13.1 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) APH PF01636.18 ESS70736.1 - 0.11 12.2 0.9 0.21 11.2 0.0 1.9 3 0 0 3 3 3 0 Phosphotransferase enzyme family UPF0542 PF15086.1 ESS70737.1 - 3.9 7.2 10.5 0.58 9.9 1.9 2.6 2 1 1 3 3 3 0 Uncharacterised protein family UPF0542 Pkinase PF00069.20 ESS70738.1 - 4.8e-56 189.7 0.0 5.5e-56 189.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70738.1 - 1e-32 113.2 0.0 1.3e-32 112.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase TruB_C PF09142.6 ESS70738.1 - 0.058 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal Peptidase_M24 PF00557.19 ESS70739.1 - 4.5e-32 111.3 0.4 5.8e-32 110.9 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3639 PF12341.3 ESS70740.1 - 0.032 14.2 0.8 0.11 12.5 0.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3639) Pkinase PF00069.20 ESS70741.1 - 7.4e-74 248.1 0.0 8.6e-74 247.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70741.1 - 1.3e-30 106.3 0.0 9.3e-30 103.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Mito_carr PF00153.22 ESS70742.1 - 3.6e-68 225.3 5.1 5.6e-25 86.8 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF4257 PF14074.1 ESS70742.1 - 0.0029 17.2 0.0 0.68 9.6 0.1 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF4257) polyprenyl_synt PF00348.12 ESS70743.1 - 5.9e-36 123.6 0.0 8.8e-36 123.0 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase CrtC PF07143.6 ESS70743.1 - 8.6e-30 104.1 0.3 1.7e-28 99.8 0.2 2.1 1 1 0 1 1 1 1 Hydroxyneurosporene synthase (CrtC) Complex1_LYR PF05347.10 ESS70744.1 - 1.2e-06 28.1 0.0 9.8e-06 25.2 0.0 2.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESS70744.1 - 0.00021 21.4 3.0 0.00041 20.4 0.0 3.1 3 1 0 3 3 3 1 Complex1_LYR-like HEAT PF02985.17 ESS70746.1 - 4.1e-06 26.4 3.2 0.98 9.6 0.0 4.2 4 0 0 4 4 4 3 HEAT repeat zf-Di19 PF05605.7 ESS70746.1 - 3.5e-05 23.8 11.7 9.1e-05 22.5 2.6 3.2 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding CLASP_N PF12348.3 ESS70746.1 - 0.00018 20.9 0.0 0.00038 19.8 0.0 1.5 1 1 0 1 1 1 1 CLASP N terminal UVR PF02151.14 ESS70746.1 - 0.021 14.3 20.1 0.075 12.5 0.6 3.5 4 0 0 4 4 4 0 UvrB/uvrC motif HEAT_EZ PF13513.1 ESS70746.1 - 0.087 13.3 4.7 12 6.4 0.0 4.2 5 0 0 5 5 5 0 HEAT-like repeat zinc-ribbons_6 PF07191.7 ESS70746.1 - 7.9 6.3 14.8 0.065 13.0 1.1 3.2 2 1 1 3 3 3 0 zinc-ribbons Kinesin PF00225.18 ESS70747.1 - 1.2e-104 349.6 0.0 2.3e-104 348.7 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain VHS PF00790.14 ESS70747.1 - 2.8e-06 26.9 0.2 3.1e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 VHS domain GAT PF03127.9 ESS70747.1 - 0.0027 17.6 0.3 0.0027 17.6 0.2 3.8 3 1 0 3 3 3 1 GAT domain Exonuc_VII_L PF02601.10 ESS70747.1 - 0.35 9.9 14.1 0.029 13.5 5.3 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit P4Ha_N PF08336.6 ESS70747.1 - 1.1 9.1 9.9 0.3 10.8 3.3 2.7 3 0 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Dynamin_N PF00350.18 ESS70749.1 - 2.5e-18 66.4 0.0 4.7e-16 59.0 0.0 2.7 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 ESS70749.1 - 4.9e-09 36.1 0.0 1.7e-08 34.4 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_10 PF12846.2 ESS70749.1 - 0.044 13.2 2.2 4.7 6.5 0.0 2.6 2 1 0 2 2 2 0 AAA-like domain DUF896 PF05979.7 ESS70749.1 - 0.061 12.9 0.1 0.22 11.1 0.1 2.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) AAA_28 PF13521.1 ESS70749.1 - 0.13 12.2 0.6 0.77 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Reprolysin PF01421.14 ESS70750.1 - 0.42 10.1 1.9 8 5.9 0.7 2.2 2 0 0 2 2 2 0 Reprolysin (M12B) family zinc metalloprotease Apc4_WD40 PF12894.2 ESS70751.1 - 0.011 15.1 0.2 3.2 7.3 0.0 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.10 ESS70752.1 - 0.00012 21.9 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sec34 PF04136.10 ESS70752.1 - 0.0037 16.9 1.0 0.011 15.4 0.0 2.1 2 0 0 2 2 2 1 Sec34-like family UCR_hinge PF02320.11 ESS70752.1 - 0.014 15.3 0.8 0.045 13.6 0.6 1.8 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein Abi_C PF14355.1 ESS70752.1 - 0.018 14.9 0.7 0.12 12.2 0.1 2.4 2 0 0 2 2 2 0 Abortive infection C-terminus THOC7 PF05615.8 ESS70752.1 - 0.065 13.5 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 IncA PF04156.9 ESS70752.1 - 0.075 12.6 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 IncA protein DUF4047 PF13256.1 ESS70752.1 - 0.096 12.6 0.7 0.18 11.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) PspA_IM30 PF04012.7 ESS70752.1 - 0.21 10.8 1.7 0.46 9.8 0.1 1.9 2 0 0 2 2 2 0 PspA/IM30 family zf-CCCH PF00642.19 ESS70752.1 - 5.6 6.7 10.1 2.1 8.1 1.9 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SUR7 PF06687.7 ESS70753.1 - 4.6e-07 29.6 1.0 4.6e-07 29.6 0.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family U-box PF04564.10 ESS70754.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 U-box domain zf-CCCH PF00642.19 ESS70754.1 - 0.18 11.5 7.2 0.07 12.8 1.5 2.3 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) InvH PF04741.7 ESS70754.1 - 3.2 7.5 11.3 0.058 13.2 1.9 2.3 2 0 0 2 2 2 0 InvH outer membrane lipoprotein UPF0016 PF01169.14 ESS70755.1 - 1.3e-43 146.9 22.9 1.6e-23 82.6 3.6 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF1355 PF07090.6 ESS70756.1 - 9.6e-06 25.0 0.0 1.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1355) ABC_transp_aux PF09822.4 ESS70756.1 - 0.0061 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system ThuA PF06283.6 ESS70756.1 - 0.045 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Trehalose utilisation WD40 PF00400.27 ESS70757.1 - 1.5e-16 59.5 16.5 5e-05 23.0 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF1143 PF06608.6 ESS70758.1 - 0.00092 19.2 0.3 0.0025 17.8 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1143) EF-hand_7 PF13499.1 ESS70758.1 - 0.0031 17.6 0.3 4 7.6 0.1 3.6 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 ESS70758.1 - 0.12 12.0 0.0 0.68 9.6 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Radical_SAM PF04055.16 ESS70759.1 - 5.9e-08 33.0 0.0 1.1e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Pkinase PF00069.20 ESS70761.1 - 2.3e-32 112.1 0.0 4.4e-17 62.0 0.0 4.1 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70761.1 - 3.5e-07 29.5 0.5 0.002 17.2 0.2 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase RIO1 PF01163.17 ESS70761.1 - 0.00094 18.5 0.1 0.0025 17.1 0.0 1.7 2 0 0 2 2 2 1 RIO1 family DUF3709 PF12493.3 ESS70761.1 - 0.016 14.8 0.4 0.038 13.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3709) WD40 PF00400.27 ESS70763.1 - 9.2e-13 47.5 0.8 3.5e-06 26.6 0.0 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat Nucleoplasmin PF03066.10 ESS70763.1 - 0.0073 15.8 5.9 0.014 14.8 4.1 1.4 1 0 0 1 1 1 1 Nucleoplasmin CPL PF08144.6 ESS70763.1 - 0.011 15.6 0.0 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 CPL (NUC119) domain TFIIA PF03153.8 ESS70763.1 - 0.14 12.0 7.0 0.23 11.2 4.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.5 ESS70763.1 - 0.89 9.8 7.5 2.4 8.4 5.2 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PDZ_2 PF13180.1 ESS70764.1 - 0.0001 22.0 0.0 0.00025 20.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Synaptobrevin PF00957.16 ESS70765.1 - 4.6e-12 45.3 0.0 1.2e-11 44.0 0.0 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.1 ESS70765.1 - 0.0073 15.8 0.0 0.038 13.5 0.0 2.1 2 0 0 2 2 2 1 Regulated-SNARE-like domain CNH PF00780.17 ESS70766.1 - 1.9e-05 24.2 0.0 0.00023 20.7 0.0 2.5 2 1 0 2 2 2 1 CNH domain DUF790 PF05626.6 ESS70766.1 - 0.17 10.3 0.0 0.28 9.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF790) TPR_2 PF07719.12 ESS70766.1 - 0.31 11.0 3.2 12 6.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4217 PF13959.1 ESS70767.1 - 0.0084 15.6 0.0 0.044 13.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) VHS PF00790.14 ESS70768.1 - 0.073 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 VHS domain DUF4611 PF15387.1 ESS70768.1 - 3.8 7.7 15.7 2.1 8.5 0.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) DUF2360 PF10152.4 ESS70769.1 - 1e-55 188.1 0.0 1.3e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein (DUF2360) Rap1-DNA-bind PF09197.5 ESS70770.1 - 0.045 14.3 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Rap1, DNA-binding HALZ PF02183.13 ESS70771.1 - 0.0046 16.6 0.8 0.0046 16.6 0.5 1.9 2 0 0 2 2 2 1 Homeobox associated leucine zipper YlqD PF11068.3 ESS70771.1 - 0.34 10.9 2.7 15 5.5 0.1 2.4 2 0 0 2 2 2 0 YlqD protein TBPIP PF07106.8 ESS70771.1 - 0.48 9.9 3.5 2 7.9 0.1 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Arginase PF00491.16 ESS70773.1 - 7.3e-53 179.6 0.0 8.2e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family IQ PF00612.22 ESS70774.1 - 0.25 11.0 37.0 2.1 8.2 3.8 7.4 7 1 0 7 7 7 0 IQ calmodulin-binding motif LRR_4 PF12799.2 ESS70775.1 - 5.8e-10 38.5 6.8 0.00023 20.7 0.0 4.0 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70775.1 - 8e-06 25.5 6.9 0.0072 16.0 0.1 3.7 3 0 0 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESS70775.1 - 1.1 9.5 6.8 1.1e+02 3.4 0.0 5.6 7 0 0 7 7 7 0 Leucine Rich Repeat Peptidase_M24 PF00557.19 ESS70776.1 - 2.1e-42 145.0 0.2 2.6e-42 144.7 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-MYND PF01753.13 ESS70776.1 - 2.8e-05 23.8 7.0 5.7e-05 22.9 4.8 1.5 1 0 0 1 1 1 1 MYND finger zf-SNAP50_C PF12251.3 ESS70776.1 - 0.8 9.0 5.2 0.28 10.5 1.8 1.6 2 0 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal DUF1042 PF06294.6 ESS70777.1 - 3e-15 56.1 0.0 6.9e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 ESS70777.1 - 0.00026 20.5 0.0 0.00056 19.5 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Prominin PF05478.6 ESS70778.1 - 0.0026 15.3 6.2 0.0026 15.3 4.3 1.9 1 1 1 2 2 2 1 Prominin Corona_S2 PF01601.11 ESS70778.1 - 0.93 7.5 11.5 0.31 9.1 5.1 1.9 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein TBCC PF07986.7 ESS70779.1 - 1.6e-30 104.9 10.0 4.5e-14 51.8 1.7 3.6 3 0 0 3 3 3 3 Tubulin binding cofactor C Pkinase PF00069.20 ESS70779.1 - 1.8e-05 23.9 0.0 0.093 11.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase PF00069.20 ESS70780.1 - 3e-47 160.9 0.2 3.4e-36 124.7 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70780.1 - 6.8e-23 81.0 0.1 2.2e-21 76.1 0.0 2.7 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70780.1 - 3.8e-07 29.3 0.0 8.5e-07 28.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS70780.1 - 0.039 13.6 0.0 0.21 11.2 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family ALMT PF11744.3 ESS70781.1 - 0.027 13.1 0.1 0.042 12.4 0.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CYTH PF01928.16 ESS70782.1 - 1.1e-13 51.3 0.6 7e-08 32.3 0.1 2.8 2 1 0 2 2 2 2 CYTH domain ANF_receptor PF01094.23 ESS70783.1 - 2.1e-29 102.3 0.1 9.3e-20 70.7 0.0 3.1 3 0 0 3 3 3 3 Receptor family ligand binding region Peripla_BP_6 PF13458.1 ESS70783.1 - 4.5e-05 22.9 0.0 0.01 15.2 0.0 2.9 2 1 0 2 2 2 2 Periplasmic binding protein HA2 PF04408.18 ESS70784.1 - 0.015 15.2 0.0 0.042 13.8 0.0 1.7 1 0 0 1 1 1 0 Helicase associated domain (HA2) AAA_11 PF13086.1 ESS70784.1 - 0.07 12.7 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain MutS_IV PF05190.13 ESS70784.1 - 0.12 12.5 0.5 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 MutS family domain IV RNA_pol_A_bac PF01000.21 ESS70785.1 - 3.8e-22 78.5 0.0 8.1e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 ESS70785.1 - 5.1e-10 38.3 0.0 7.4e-10 37.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.1 ESS70785.1 - 0.25 11.6 2.0 0.49 10.6 1.4 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Utp11 PF03998.8 ESS70787.1 - 5.8e-52 176.9 18.6 5.8e-52 176.9 12.9 2.0 1 1 0 2 2 2 1 Utp11 protein SCHIP-1 PF10148.4 ESS70787.1 - 0.018 14.4 3.3 0.56 9.5 0.3 2.3 2 0 0 2 2 2 0 Schwannomin-interacting protein 1 PAS_10 PF13596.1 ESS70787.1 - 0.02 15.1 2.3 10 6.4 0.0 3.4 3 0 0 3 3 3 0 PAS domain Kinesin PF00225.18 ESS70788.1 - 9.7e-90 300.6 0.7 9.7e-90 300.6 0.5 4.6 4 1 0 4 4 4 1 Kinesin motor domain AAA_22 PF13401.1 ESS70788.1 - 1.3 9.2 0.0 1.3 9.2 0.0 3.3 3 1 0 3 3 3 0 AAA domain DUF948 PF06103.6 ESS70788.1 - 2.3 8.1 6.0 1.4 8.8 0.2 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Ribosomal_S13_N PF08069.7 ESS70789.1 - 2.2e-23 81.8 0.8 3.7e-23 81.1 0.1 1.8 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 ESS70789.1 - 2.8e-23 81.4 0.3 3.5e-23 81.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S15 DUF3989 PF13150.1 ESS70790.1 - 0.022 14.2 0.5 0.031 13.7 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) Cytochrom_B_N_2 PF13631.1 ESS70790.1 - 0.42 10.3 2.4 1.6 8.5 1.7 1.7 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Cons_hypoth698 PF03601.9 ESS70791.1 - 0.0038 15.9 0.0 0.0056 15.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 698 DUF1412 PF07203.6 ESS70791.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1412) NAP PF00956.13 ESS70792.1 - 1.6e-62 210.8 0.1 1.6e-62 210.8 0.1 2.0 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) DUF4576 PF15144.1 ESS70792.1 - 0.0094 15.5 1.0 0.018 14.6 0.5 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4576) Mpp10 PF04006.7 ESS70792.1 - 0.021 13.1 14.0 0.039 12.3 9.7 1.4 1 0 0 1 1 1 0 Mpp10 protein Nucleoplasmin PF03066.10 ESS70792.1 - 0.035 13.6 20.6 0.12 11.9 0.7 2.5 2 0 0 2 2 2 0 Nucleoplasmin PBP1_TM PF14812.1 ESS70792.1 - 0.13 12.5 20.9 0.18 12.1 4.2 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SDA1 PF05285.7 ESS70792.1 - 0.16 11.2 10.8 0.36 10.0 7.5 1.6 1 0 0 1 1 1 0 SDA1 Daxx PF03344.10 ESS70792.1 - 0.59 8.5 12.7 1.1 7.5 8.8 1.4 1 0 0 1 1 1 0 Daxx Family NOA36 PF06524.7 ESS70792.1 - 2.6 7.2 12.4 5.4 6.1 0.7 2.2 2 0 0 2 2 2 0 NOA36 protein RXT2_N PF08595.6 ESS70792.1 - 7.4 6.3 14.6 3.4 7.4 0.4 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.5 ESS70792.1 - 8 6.7 32.9 1.1 9.4 9.6 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain TFIIS_C PF01096.13 ESS70793.1 - 1.9e-16 59.3 3.1 1.9e-16 59.3 2.1 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 ESS70793.1 - 1.9e-07 30.6 1.5 6.9e-07 28.8 0.1 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.7 ESS70793.1 - 0.00027 20.1 1.2 0.02 14.2 0.3 2.7 2 0 0 2 2 2 1 TFIIB zinc-binding DZR PF12773.2 ESS70793.1 - 0.0045 16.7 5.3 0.074 12.8 0.2 2.4 2 0 0 2 2 2 1 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 ESS70793.1 - 0.026 14.3 5.0 0.27 11.0 0.3 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Runt PF00853.14 ESS70793.1 - 0.048 13.1 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Runt domain OrfB_Zn_ribbon PF07282.6 ESS70793.1 - 0.059 13.0 3.4 3.4 7.3 0.1 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Baculo_LEF5_C PF11792.3 ESS70793.1 - 0.15 11.4 0.2 0.15 11.4 0.1 1.8 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zf-ribbon_3 PF13248.1 ESS70793.1 - 0.22 10.7 0.5 0.22 10.7 0.3 4.0 5 0 0 5 5 5 0 zinc-ribbon domain zf-H2C2_5 PF13909.1 ESS70793.1 - 0.26 11.6 0.4 0.26 11.6 0.3 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-piccolo PF05715.8 ESS70793.1 - 0.73 9.8 5.5 0.39 10.7 1.1 2.4 2 1 0 2 2 2 0 Piccolo Zn-finger Nudix_N_2 PF14803.1 ESS70793.1 - 1 9.0 7.6 0.55 9.9 2.0 2.8 2 1 0 2 2 2 0 Nudix N-terminal DUF2296 PF10058.4 ESS70793.1 - 1.1 9.0 5.7 12 5.7 0.0 3.2 3 0 0 3 3 3 0 Predicted integral membrane metal-binding protein (DUF2296) IBR PF01485.16 ESS70793.1 - 1.2 9.0 7.2 6.3 6.7 0.1 3.0 2 1 0 2 2 2 0 IBR domain zf-Mss51 PF13824.1 ESS70793.1 - 1.2 9.0 5.3 9.8 6.1 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-H2C2_2 PF13465.1 ESS70793.1 - 3.9 7.9 10.1 4.5 7.7 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double domain Zn-ribbon_8 PF09723.5 ESS70793.1 - 5.9 6.9 6.7 64 3.6 0.3 3.5 4 0 0 4 4 3 0 Zinc ribbon domain Lar_restr_allev PF14354.1 ESS70793.1 - 8.1 6.8 8.2 7.5e+02 0.5 5.7 2.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar Histone PF00125.19 ESS70794.1 - 7.5e-24 83.6 0.1 1.4e-23 82.7 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESS70794.1 - 1.3e-05 25.1 0.0 2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESS70794.1 - 0.0063 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated CENP-S PF15630.1 ESS70794.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Kinetochore component CENP-S TFIID-31kDa PF02291.10 ESS70794.1 - 0.05 13.3 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit UPF0179 PF03684.8 ESS70794.1 - 0.088 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0179) UMP1 PF05348.6 ESS70795.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 Dynamin_M PF01031.15 ESS70826.1 - 4.2e-89 298.2 0.5 7e-89 297.5 0.3 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 ESS70826.1 - 5e-49 166.3 0.2 1.6e-48 164.7 0.0 2.0 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 ESS70826.1 - 1.9e-23 82.1 1.2 5.3e-23 80.7 0.3 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 ESS70826.1 - 1.1e-05 25.3 0.2 5e-05 23.2 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESS70826.1 - 0.013 15.9 0.0 0.034 14.6 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 ESS70826.1 - 0.051 13.1 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 ESS70826.1 - 0.096 12.6 0.1 3.1 7.7 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain LRR_9 PF14580.1 ESS70827.1 - 4.8e-16 58.8 0.7 4.8e-16 58.8 0.5 1.4 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.2 ESS70827.1 - 8.8e-15 53.9 4.1 2.8e-08 33.1 0.6 3.3 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70827.1 - 2.4e-09 36.7 4.0 7.9e-08 31.9 1.7 3.0 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 ESS70827.1 - 0.00026 20.5 5.2 2.6 8.4 0.2 4.5 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.1 ESS70827.1 - 0.044 13.8 6.5 8.1 6.8 0.1 4.4 3 1 2 5 5 5 0 Leucine Rich repeat Spc7_N PF15402.1 ESS70827.1 - 1.6 6.6 5.5 2 6.3 3.8 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 LRR_7 PF13504.1 ESS70827.1 - 5.9 7.5 7.1 1.4e+02 3.3 0.8 4.7 5 1 0 5 5 5 0 Leucine rich repeat NAD_Gly3P_dh_N PF01210.18 ESS70828.1 - 9.2e-08 31.9 0.0 4.8e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 ESS70828.1 - 0.0084 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 ESS70828.1 - 0.01 16.2 0.0 0.041 14.3 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_M1 PF01433.15 ESS70829.1 - 1.3e-93 314.1 0.0 1.8e-93 313.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 ESS70829.1 - 3.2e-15 56.2 0.0 5e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 ESS70829.1 - 6.1e-13 48.9 0.1 1.8e-12 47.3 0.1 1.9 1 1 0 1 1 1 1 Peptidase MA superfamily DUF2316 PF10078.4 ESS70830.1 - 0.0059 16.5 0.8 0.024 14.5 0.3 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2316) DUF4140 PF13600.1 ESS70830.1 - 0.012 16.0 0.9 0.012 16.0 0.6 3.8 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) DUF2365 PF10157.4 ESS70830.1 - 0.012 15.4 1.1 0.054 13.3 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2365) IncA PF04156.9 ESS70830.1 - 0.44 10.1 29.1 1.2 8.6 5.2 3.8 3 1 0 3 3 3 0 IncA protein FlxA PF14282.1 ESS70830.1 - 4.3 7.3 16.8 1.1 9.2 1.4 4.1 4 0 0 4 4 4 0 FlxA-like protein DUF2458 PF10454.4 ESS70830.1 - 4.4 7.1 19.5 0.067 13.0 1.4 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2458) HrpB7 PF09486.5 ESS70830.1 - 6.5 6.6 29.1 0.65 9.9 1.5 4.2 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF972 PF06156.8 ESS70830.1 - 7.1 7.0 23.3 0.036 14.3 1.8 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF972) Sld5 PF05916.6 ESS70831.1 - 1.6e-06 28.3 0.0 3.1e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 GINS complex protein DUF2835 PF11197.3 ESS70832.1 - 0.1 12.4 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2835) Acyltransferase PF01553.16 ESS70833.1 - 3.7e-13 49.0 0.7 9.3e-13 47.7 0.0 1.9 2 0 0 2 2 2 1 Acyltransferase DUF4131 PF13567.1 ESS70833.1 - 0.74 9.2 7.1 1.3 8.3 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Oxidored_q1_N PF00662.15 ESS70834.1 - 8.9 5.9 8.0 4.3 6.9 1.2 2.3 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus UCH PF00443.24 ESS70835.1 - 5.7e-52 176.4 0.1 8.9e-52 175.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESS70835.1 - 1.5e-22 80.3 0.1 2.9e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 ESS70835.1 - 3.1e-17 62.4 5.3 3.1e-17 62.4 3.7 4.3 5 0 0 5 5 5 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 ESS70835.1 - 1.4e-06 27.9 0.4 3.3e-06 26.7 0.3 1.7 1 0 0 1 1 1 1 UBA/TS-N domain ECH PF00378.15 ESS70836.1 - 4.5e-76 255.2 3.2 5.1e-76 255.0 2.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 ESS70836.1 - 0.00015 21.5 0.2 0.068 12.9 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 ECH_C PF13766.1 ESS70836.1 - 0.00025 21.1 0.1 0.00056 20.0 0.1 1.6 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region Smr PF01713.16 ESS70836.1 - 0.14 12.3 0.0 0.48 10.6 0.0 1.9 2 0 0 2 2 2 0 Smr domain Pkinase PF00069.20 ESS70837.1 - 2.1e-54 184.3 0.0 2.8e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70837.1 - 6.8e-33 113.8 0.0 9.6e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS70837.1 - 0.00033 20.4 0.0 0.031 14.0 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS70837.1 - 0.00078 18.4 0.0 0.0016 17.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.6 ESS70837.1 - 0.059 12.1 0.0 0.083 11.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 ESS70837.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 FlgN PF05130.7 ESS70839.1 - 0.0017 18.6 1.6 1.9 8.7 0.1 2.6 2 0 0 2 2 2 2 FlgN protein Apolipoprotein PF01442.13 ESS70839.1 - 0.0033 16.9 1.0 0.013 15.0 0.7 1.9 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Peptidase_M18 PF02127.10 ESS70840.1 - 6.9e-154 512.4 0.0 7.8e-154 512.3 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 ESS70840.1 - 7.6e-07 28.1 0.0 0.00017 20.4 0.0 2.1 1 1 1 2 2 2 2 M42 glutamyl aminopeptidase Colicin_C PF12106.3 ESS70840.1 - 0.33 10.5 0.9 0.54 9.8 0.1 1.8 2 0 0 2 2 2 0 Colicin C terminal ribonuclease domain Kinesin PF00225.18 ESS70841.1 - 4.6e-90 301.7 0.5 6.6e-90 301.1 0.4 1.2 1 0 0 1 1 1 1 Kinesin motor domain C2 PF00168.25 ESS70841.1 - 0.00039 20.2 0.0 0.00083 19.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain GAS PF13851.1 ESS70841.1 - 0.035 13.3 3.7 0.062 12.4 2.6 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RFamide_26RFa PF11109.3 ESS70841.1 - 0.078 12.8 0.2 0.55 10.1 0.1 2.2 2 0 0 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 NIF PF03031.13 ESS70842.1 - 3.9e-30 104.6 0.0 5.8e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.7 ESS70842.1 - 0.15 11.0 0.1 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF705) SET PF00856.23 ESS70843.1 - 1.3e-08 35.3 0.5 9.9e-05 22.6 0.0 2.7 3 0 0 3 3 3 2 SET domain Acyltransferase PF01553.16 ESS70844.1 - 5.1e-09 35.6 0.0 8.6e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase JmjN PF02375.12 ESS70844.1 - 0.073 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 jmjN domain PDEase_I PF00233.14 ESS70846.1 - 4.4e-58 196.8 1.7 6.4e-58 196.2 1.2 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAS PF13851.1 ESS70846.1 - 0.048 12.8 0.2 0.078 12.1 0.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Ribosomal_L13e PF01294.13 ESS70847.1 - 2.1e-54 183.6 5.7 2.1e-54 183.6 3.9 1.6 1 1 1 2 2 2 1 Ribosomal protein L13e IGR PF09597.5 ESS70848.1 - 0.14 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 IGR protein motif GerA PF03323.8 ESS70848.1 - 1.1 7.3 0.6 1.6 6.7 0.4 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein Pkinase PF00069.20 ESS70849.1 - 7.2e-41 140.0 0.0 1e-40 139.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70849.1 - 4.1e-26 91.6 0.0 5.4e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-B_box PF00643.19 ESS70849.1 - 0.00018 21.2 15.0 0.0015 18.3 2.0 5.8 6 1 1 7 7 7 3 B-box zinc finger Pox_ser-thr_kin PF05445.6 ESS70849.1 - 0.014 14.1 0.2 0.021 13.6 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.15 ESS70849.1 - 0.033 13.7 0.1 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.9 ESS70849.1 - 0.085 11.9 0.1 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESS70849.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA PF00004.24 ESS70850.1 - 7.3e-39 132.9 0.1 2.2e-38 131.4 0.0 1.9 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ESS70850.1 - 8.8e-26 89.5 0.0 3.7e-25 87.5 0.0 2.1 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 ESS70850.1 - 6.1e-21 74.0 1.8 6.1e-21 74.0 1.2 2.0 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 ESS70850.1 - 2.1e-06 28.5 0.1 3e-05 24.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ESS70850.1 - 1.5e-05 24.9 0.4 4.2e-05 23.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESS70850.1 - 1.8e-05 24.8 0.7 0.00071 19.7 0.0 3.0 2 2 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESS70850.1 - 2.9e-05 23.8 0.0 0.00014 21.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESS70850.1 - 8.7e-05 22.4 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 ESS70850.1 - 0.00028 20.3 0.0 0.00058 19.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESS70850.1 - 0.00041 20.2 0.0 0.002 18.0 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESS70850.1 - 0.00061 19.8 0.0 0.011 15.7 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 ESS70850.1 - 0.00066 19.1 0.5 0.17 11.3 0.1 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 ESS70850.1 - 0.00084 18.4 0.0 0.0018 17.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ESS70850.1 - 0.0027 16.6 0.0 0.0062 15.5 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) TIP49 PF06068.8 ESS70850.1 - 0.0043 15.8 0.2 0.0079 14.9 0.0 1.5 2 0 0 2 2 2 1 TIP49 C-terminus Zeta_toxin PF06414.7 ESS70850.1 - 0.0057 15.7 0.0 0.017 14.2 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin RNA_helicase PF00910.17 ESS70850.1 - 0.0084 16.2 0.0 0.025 14.7 0.0 1.9 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 ESS70850.1 - 0.0085 15.2 0.0 0.022 13.9 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESS70850.1 - 0.01 15.3 0.0 0.054 12.9 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.1 ESS70850.1 - 0.019 14.5 0.2 0.07 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 ESS70850.1 - 0.04 13.4 0.0 0.074 12.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 ESS70850.1 - 0.054 13.2 0.1 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain AAA_28 PF13521.1 ESS70850.1 - 0.076 12.9 0.0 0.23 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain Ribosomal_60s PF00428.14 ESS70850.1 - 0.086 13.2 2.3 0.26 11.7 1.6 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein PhoH PF02562.11 ESS70850.1 - 0.092 11.9 0.0 0.25 10.5 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_10 PF12846.2 ESS70850.1 - 0.13 11.6 0.8 0.95 8.8 0.0 2.6 4 0 0 4 4 4 0 AAA-like domain Arch_ATPase PF01637.13 ESS70850.1 - 0.16 11.6 2.0 4.9 6.7 0.0 3.1 2 2 2 4 4 4 0 Archaeal ATPase USP8_dimer PF08969.6 ESS70850.1 - 0.18 11.7 3.7 0.43 10.5 2.5 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain PFK PF00365.15 ESS70851.1 - 9.6e-36 123.1 1.7 1.7e-35 122.3 1.2 1.3 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.16 ESS70851.1 - 0.00096 18.0 0.0 0.0017 17.1 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase TFIIF_alpha PF05793.7 ESS70852.1 - 0.0012 17.3 10.3 0.0012 17.3 7.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Prog_receptor PF02161.10 ESS70852.1 - 0.0038 16.1 7.5 0.0044 15.9 5.2 1.1 1 0 0 1 1 1 1 Progesterone receptor Daxx PF03344.10 ESS70852.1 - 0.0063 15.0 12.7 0.0063 15.0 8.8 1.1 1 0 0 1 1 1 1 Daxx Family CDC45 PF02724.9 ESS70852.1 - 0.015 13.3 6.0 0.014 13.4 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Spore_coat_CotO PF14153.1 ESS70852.1 - 0.016 14.6 5.5 0.016 14.6 3.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Ycf1 PF05758.7 ESS70852.1 - 0.027 12.2 2.3 0.03 12.0 1.6 1.0 1 0 0 1 1 1 0 Ycf1 Nop14 PF04147.7 ESS70852.1 - 0.3 8.9 20.8 0.39 8.5 14.4 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.10 ESS70852.1 - 0.55 8.8 3.4 0.55 8.7 2.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sigma70_ner PF04546.8 ESS70852.1 - 0.82 9.2 14.6 1.4 8.5 10.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Tim54 PF11711.3 ESS70852.1 - 0.84 8.1 7.9 1.1 7.8 5.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sporozoite_P67 PF05642.6 ESS70852.1 - 0.99 7.1 8.5 1.3 6.8 5.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SDA1 PF05285.7 ESS70852.1 - 1.3 8.2 18.4 1.8 7.7 12.7 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.5 ESS70852.1 - 1.7 7.5 15.3 2.3 7.1 10.6 1.2 1 0 0 1 1 1 0 BUD22 Vfa1 PF08432.5 ESS70852.1 - 2 8.3 8.8 2.9 7.8 6.1 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF605 PF04652.11 ESS70852.1 - 2.3 7.5 9.8 2.6 7.3 6.8 1.2 1 0 0 1 1 1 0 Vta1 like XAP5 PF04921.9 ESS70852.1 - 3.2 7.2 8.6 5.1 6.5 6.0 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator Paf1 PF03985.8 ESS70852.1 - 3.7 6.1 21.2 5.2 5.6 14.7 1.2 1 0 0 1 1 1 0 Paf1 YqfQ PF14181.1 ESS70852.1 - 4 7.4 8.3 6 6.8 5.7 1.5 1 0 0 1 1 1 0 YqfQ-like protein Lin-8 PF03353.10 ESS70852.1 - 4 6.6 10.4 5.2 6.2 7.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1510 PF07423.6 ESS70852.1 - 5.5 6.2 17.8 7.7 5.8 12.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Menin PF05053.8 ESS70852.1 - 7.7 4.5 8.4 9.1 4.3 5.8 1.1 1 0 0 1 1 1 0 Menin zf-MIZ PF02891.15 ESS70853.1 - 6.9e-05 22.2 0.1 0.00079 18.8 0.0 2.3 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger Nol1_Nop2_Fmu PF01189.12 ESS70854.1 - 3.6e-30 105.3 0.0 4.4e-28 98.4 0.0 2.5 2 0 0 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 ESS70854.1 - 1.1e-05 25.4 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESS70854.1 - 0.00019 21.4 0.0 0.00048 20.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS70854.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TPR_19 PF14559.1 ESS70855.1 - 7.6e-19 67.8 13.4 9.5e-10 38.6 0.6 7.9 8 1 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESS70855.1 - 1.4e-15 56.6 10.4 0.00078 19.0 0.1 7.6 7 1 2 9 9 9 4 TPR repeat TPR_16 PF13432.1 ESS70855.1 - 8.1e-12 45.4 38.2 0.0061 17.2 0.1 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESS70855.1 - 6.7e-11 41.2 6.9 0.012 15.4 0.0 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS70855.1 - 1.9e-08 33.5 1.3 0.0096 15.5 0.0 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS70855.1 - 5.4e-08 32.8 10.8 0.047 13.8 0.1 6.5 4 2 4 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESS70855.1 - 4.1e-06 26.9 35.2 0.038 14.6 0.3 10.2 8 3 3 11 11 10 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70855.1 - 8.2e-05 22.4 27.8 0.72 9.8 1.3 7.8 6 3 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESS70855.1 - 0.0016 18.4 6.5 76 3.8 0.2 7.6 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70855.1 - 0.021 14.6 12.7 0.11 12.3 0.2 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS70855.1 - 0.81 10.3 9.2 11 6.8 1.3 5.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS70855.1 - 6.4 7.4 23.1 22 5.7 0.0 8.9 12 0 0 12 12 10 0 Tetratricopeptide repeat DUF4586 PF15239.1 ESS70856.1 - 4.7e-82 275.9 12.0 5.6e-82 275.6 8.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Pkinase PF00069.20 ESS70858.1 - 5e-66 222.5 0.1 9.5e-66 221.5 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70858.1 - 8.4e-47 159.4 0.0 1.5e-46 158.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70858.1 - 4e-07 29.3 0.1 8.5e-07 28.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like DUF721 PF05258.7 ESS70858.1 - 0.018 15.2 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF721) APH PF01636.18 ESS70858.1 - 0.14 11.8 0.0 5.4 6.6 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Lipase_chap PF03280.9 ESS70858.1 - 2.8 7.4 5.3 1.7 8.1 0.1 2.2 2 0 0 2 2 2 0 Proteobacterial lipase chaperone protein PAP_central PF04928.12 ESS70861.1 - 1.6e-62 210.5 0.0 2.2e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 ESS70861.1 - 0.0017 17.8 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain EzrA PF06160.7 ESS70862.1 - 0.0095 14.1 3.1 0.18 9.9 0.1 2.6 2 0 0 2 2 2 2 Septation ring formation regulator, EzrA HalX PF08663.5 ESS70862.1 - 0.046 13.7 6.8 0.11 12.4 1.1 3.5 3 1 0 3 3 3 0 HalX domain Mnd1 PF03962.10 ESS70862.1 - 0.43 10.2 5.6 0.78 9.3 0.4 3.5 2 2 1 3 3 3 0 Mnd1 family bZIP_2 PF07716.10 ESS70862.1 - 7.4 6.4 20.7 0.43 10.4 0.2 4.0 5 0 0 5 5 5 0 Basic region leucine zipper Ribosomal_L50 PF10501.4 ESS70863.1 - 0.0027 17.6 0.4 0.17 11.8 0.1 3.3 3 0 0 3 3 3 1 Ribosomal subunit 39S Intein_splicing PF14890.1 ESS70863.1 - 0.0035 16.3 0.0 0.0077 15.1 0.0 1.6 1 0 0 1 1 1 1 Intein splicing domain SAM_2 PF07647.12 ESS70863.1 - 0.0053 16.5 0.0 0.016 14.9 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cnd3 PF12719.2 ESS70865.1 - 1.1e-20 73.7 0.6 1.1e-20 73.7 0.5 2.3 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 ESS70865.1 - 1.1e-07 32.0 2.9 0.00016 21.8 0.1 5.2 5 1 0 6 6 6 1 HEAT repeats HEAT PF02985.17 ESS70865.1 - 0.00022 21.0 7.7 3.1 8.1 0.2 5.6 5 0 0 5 5 5 2 HEAT repeat GvpG PF05120.7 ESS70865.1 - 0.31 10.8 1.9 0.57 10.0 0.7 1.9 2 0 0 2 2 2 0 Gas vesicle protein G HEAT_EZ PF13513.1 ESS70865.1 - 0.32 11.5 11.4 0.4 11.2 0.1 4.4 5 0 0 5 5 5 0 HEAT-like repeat Rotamase PF00639.16 ESS70866.1 - 1.6e-22 80.0 0.0 2.6e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 ESS70866.1 - 1.7e-22 79.8 0.0 2.1e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 ESS70866.1 - 1.4e-09 38.6 0.0 1.9e-09 38.1 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain DUF217 PF02697.9 ESS70866.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized ACR, COG1753 Helicase_C_2 PF13307.1 ESS70867.1 - 1.5e-50 171.4 0.0 3.4e-50 170.2 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESS70867.1 - 8.1e-44 149.0 1.1 1.4e-43 148.3 0.1 1.9 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.24 ESS70867.1 - 1.7e-07 30.8 0.0 0.00095 18.6 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_19 PF13245.1 ESS70867.1 - 5.4e-05 22.8 0.0 0.00024 20.7 0.0 2.2 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 ESS70867.1 - 0.00024 20.9 0.0 0.0032 17.3 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_11 PF13086.1 ESS70867.1 - 0.017 14.6 0.0 0.04 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain SPARC_Ca_bdg PF10591.4 ESS70867.1 - 0.05 13.6 0.9 0.17 11.9 0.6 1.8 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SNF2_N PF00176.18 ESS70867.1 - 0.18 10.5 0.0 0.9 8.2 0.0 2.0 1 1 0 1 1 1 0 SNF2 family N-terminal domain Pkinase PF00069.20 ESS70868.1 - 9.9e-61 205.1 0.0 3.4e-60 203.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70868.1 - 1.3e-36 125.9 0.0 2.5e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70868.1 - 1e-09 37.7 0.0 3.2e-07 29.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 ESS70868.1 - 0.067 12.9 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PDEase_I PF00233.14 ESS70869.1 - 9.9e-45 153.1 0.0 1.5e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase FYVE PF01363.16 ESS70869.1 - 2.1e-06 27.5 14.6 3.7e-06 26.7 10.1 1.4 1 0 0 1 1 1 1 FYVE zinc finger Herpes_UL6 PF01763.11 ESS70869.1 - 0.017 13.3 0.1 0.036 12.2 0.0 1.5 1 1 0 1 1 1 0 Herpesvirus UL6 like End3 PF12761.2 ESS70869.1 - 0.032 13.8 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Tropomyosin PF00261.15 ESS70869.1 - 0.99 8.4 14.7 0.95 8.4 4.7 2.5 2 1 0 2 2 2 0 Tropomyosin IncA PF04156.9 ESS70869.1 - 2 7.9 9.0 6.1 6.3 0.4 3.1 3 0 0 3 3 3 0 IncA protein UNC-79 PF14776.1 ESS70869.1 - 4 5.6 8.4 6.2 5.0 5.8 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Cep57_CLD_2 PF14197.1 ESS70869.1 - 6.3 6.8 16.5 0.5 10.3 3.1 3.8 4 0 0 4 4 4 0 Centrosome localisation domain of PPC89 DUF2732 PF10809.3 ESS70870.1 - 0.051 13.1 4.9 0.57 9.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2732) PPR PF01535.15 ESS70872.1 - 0.068 13.1 0.1 0.52 10.4 0.0 2.6 2 0 0 2 2 2 0 PPR repeat Beta_helix PF13229.1 ESS70873.1 - 4.3e-20 72.0 8.1 1.1e-16 60.9 5.6 2.2 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 ESS70873.1 - 1.5e-12 47.1 0.3 2e-12 46.8 0.2 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pectinesterase PF01095.14 ESS70873.1 - 0.05 12.1 0.1 0.12 10.9 0.0 1.6 1 1 1 2 2 2 0 Pectinesterase Pectate_lyase_3 PF12708.2 ESS70873.1 - 0.056 13.5 4.3 2 8.4 3.2 2.2 1 1 1 2 2 2 0 Pectate lyase superfamily protein Pkinase PF00069.20 ESS70874.1 - 1.1e-36 126.3 0.0 3.7e-36 124.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70874.1 - 2.1e-21 76.1 0.0 3.1e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ESS70874.1 - 0.00076 18.8 0.0 0.0014 17.9 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESS70874.1 - 0.0076 15.3 0.0 0.015 14.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family START PF01852.14 ESS70875.1 - 1.3e-26 93.2 0.0 1.9e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 START domain DUF3074 PF11274.3 ESS70875.1 - 1.5e-05 24.7 0.0 9.1e-05 22.1 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) Actin PF00022.14 ESS70876.1 - 1e-13 50.5 0.0 5.7e-11 41.4 0.0 2.5 2 1 0 2 2 2 1 Actin TPR_19 PF14559.1 ESS70877.1 - 1.7e-14 53.9 0.0 0.0007 19.8 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESS70877.1 - 3.4e-12 46.6 0.0 8.9e-05 23.0 0.0 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat Apc3 PF12895.2 ESS70877.1 - 2.5e-11 43.5 15.0 0.0016 18.5 3.2 5.4 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESS70877.1 - 6.2e-11 41.3 15.8 0.021 14.6 0.1 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS70877.1 - 1.3e-09 37.7 0.9 0.14 12.8 0.0 5.7 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS70877.1 - 2.5e-09 36.6 6.4 0.00023 20.7 0.0 4.3 4 0 0 4 4 4 2 TPR repeat TPR_1 PF00515.23 ESS70877.1 - 2.5e-06 26.8 6.5 0.31 10.7 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESS70877.1 - 0.00022 21.4 3.5 25 5.6 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS70877.1 - 0.00039 20.0 1.3 0.34 10.8 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESS70877.1 - 0.00055 19.8 8.5 0.71 9.8 0.1 5.9 4 2 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESS70877.1 - 0.0036 16.9 3.3 68 3.5 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS70877.1 - 0.012 15.4 0.1 0.45 10.4 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS70877.1 - 0.013 15.8 0.0 3.2 8.4 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESS70877.1 - 0.018 14.9 3.4 1.3 9.0 0.3 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 ESS70877.1 - 0.024 14.5 1.3 5.4 7.1 0.1 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Mito_carr PF00153.22 ESS70878.1 - 8.6e-58 192.0 0.9 6.7e-20 70.5 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein IU_nuc_hydro PF01156.14 ESS70879.1 - 9.8e-49 166.2 0.0 1.1e-48 166.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LRR_6 PF13516.1 ESS70880.1 - 9.9e-32 105.4 23.9 0.00036 20.2 0.4 12.4 12 0 0 12 12 12 7 Leucine Rich repeat LRR_1 PF00560.28 ESS70880.1 - 9.9e-14 49.2 9.5 0.28 11.3 0.0 10.6 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_4 PF12799.2 ESS70880.1 - 2.9e-11 42.7 15.6 0.0014 18.2 0.7 7.1 3 2 6 9 9 9 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70880.1 - 2.4e-08 33.5 20.7 0.001 18.7 1.6 6.7 3 2 4 7 7 7 4 Leucine rich repeat LRR_7 PF13504.1 ESS70880.1 - 0.0055 16.6 22.5 4.4 7.9 0.1 9.3 10 0 0 10 10 10 1 Leucine rich repeat HAUS-augmin3 PF14932.1 ESS70880.1 - 0.06 12.5 6.4 0.27 10.3 2.3 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Hydantoinase_A PF01968.13 ESS70880.1 - 2.3 7.2 8.0 0.5 9.4 0.0 2.4 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase Atg14 PF10186.4 ESS70880.1 - 5.4 5.8 8.6 12 4.7 6.0 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 RRM_1 PF00076.17 ESS70882.1 - 1.1e-17 63.3 0.0 1.6e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS70882.1 - 5.2e-14 51.9 0.0 8.1e-14 51.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS70882.1 - 1.4e-08 34.4 0.0 2.1e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.17 ESS70882.1 - 0.0048 15.9 18.9 0.0048 15.9 13.1 1.4 2 0 0 2 2 2 1 ZIP Zinc transporter Limkain-b1 PF11608.3 ESS70882.1 - 0.014 15.1 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 Limkain b1 Otopetrin PF03189.8 ESS70882.1 - 0.055 12.4 2.0 0.054 12.4 1.4 1.1 1 0 0 1 1 1 0 Otopetrin MMR1 PF08505.5 ESS70882.1 - 0.8 9.6 10.0 1.1 9.2 7.0 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Med15 PF09606.5 ESS70882.1 - 0.82 7.7 39.0 1 7.4 27.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Macoilin PF09726.4 ESS70882.1 - 1.4 7.0 14.9 1.7 6.7 10.3 1.1 1 0 0 1 1 1 0 Transmembrane protein TFIIA PF03153.8 ESS70882.1 - 8 6.2 19.8 11 5.8 13.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 2TM PF13239.1 ESS70883.1 - 0.0027 17.7 0.1 0.0027 17.7 0.1 2.3 2 0 0 2 2 2 1 2TM domain EIF_2_alpha PF07541.7 ESS70884.1 - 3.1e-25 88.0 0.0 5.5e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 ESS70884.1 - 6.1e-10 39.0 1.2 1.2e-09 38.1 0.8 1.5 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.4 ESS70884.1 - 0.0034 17.2 0.8 0.0067 16.3 0.6 1.6 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 Pkinase PF00069.20 ESS70885.1 - 2.3e-11 43.3 0.0 7.3e-11 41.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain MORN PF02493.15 ESS70886.1 - 2.4e-22 77.2 37.5 7e-07 28.6 2.1 6.8 7 0 0 7 7 7 6 MORN repeat TFIIIC_sub6 PF10419.4 ESS70886.1 - 0.37 10.3 2.5 31 4.1 0.0 3.4 2 1 1 3 3 3 0 TFIIIC subunit Cu-oxidase_2 PF07731.9 ESS70887.1 - 4.7e-17 61.7 1.5 1.2e-16 60.4 0.1 2.5 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 ESS70887.1 - 4.2e-09 36.1 2.2 2.5e-05 23.9 0.2 3.5 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 ESS70887.1 - 0.038 13.8 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Multicopper oxidase STT3 PF02516.9 ESS70887.1 - 0.11 11.4 1.3 0.23 10.3 0.6 1.6 2 0 0 2 2 2 0 Oligosaccharyl transferase STT3 subunit Brix PF04427.13 ESS70891.1 - 9e-42 142.9 0.1 1.3e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 Brix domain NIF PF03031.13 ESS70892.1 - 4.5e-28 97.9 0.0 6.6e-17 61.6 0.0 2.2 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase AA_kinase PF00696.23 ESS70894.1 - 0.023 14.2 0.5 0.52 9.7 0.0 2.3 2 0 0 2 2 2 0 Amino acid kinase family Urb2 PF10441.4 ESS70894.1 - 0.093 12.3 5.4 0.71 9.4 0.5 2.5 2 0 0 2 2 2 0 Urb2/Npa2 family Tospo_nucleocap PF01533.11 ESS70894.1 - 0.11 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein LRR_4 PF12799.2 ESS70896.1 - 1.2e-10 40.7 2.1 0.00094 18.7 0.0 4.3 3 2 3 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70896.1 - 0.00037 20.1 8.8 0.0095 15.6 1.0 2.8 1 1 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 ESS70896.1 - 0.017 15.1 11.2 8.7 6.8 0.0 6.3 5 2 1 6 6 6 0 Leucine Rich Repeat LRR_9 PF14580.1 ESS70896.1 - 0.13 11.7 1.1 0.63 9.5 0.4 2.0 1 1 1 2 2 2 0 Leucine-rich repeat Mito_fiss_reg PF05308.6 ESS70898.1 - 0.0017 17.7 0.3 0.0027 17.0 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial fission regulator zf-MYND PF01753.13 ESS70900.1 - 0.00026 20.8 3.5 0.00051 19.8 2.4 1.5 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.11 ESS70900.1 - 0.025 14.2 2.3 0.04 13.5 1.6 1.3 1 0 0 1 1 1 0 HIT zinc finger CDP-OH_P_transf PF01066.16 ESS70902.1 - 5.8e-23 81.1 0.5 5.8e-23 81.1 0.3 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF2325 PF10087.4 ESS70902.1 - 0.084 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) 6PF2K PF01591.13 ESS70904.1 - 5.8e-65 218.4 0.1 1.3e-64 217.3 0.1 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Ank_2 PF12796.2 ESS70904.1 - 7.6e-15 55.0 0.1 2.1e-14 53.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESS70904.1 - 2.1e-14 52.4 0.9 2.7e-09 36.3 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESS70904.1 - 1.1e-11 44.8 0.3 2.3e-06 27.9 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS70904.1 - 5.1e-10 38.6 1.4 0.00043 20.2 0.0 4.0 4 0 0 4 4 3 2 Ankyrin repeat Ank_5 PF13857.1 ESS70904.1 - 2.9e-08 33.7 0.3 9e-08 32.1 0.2 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) AAA_33 PF13671.1 ESS70904.1 - 2.4e-07 30.7 0.3 6.3e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS70904.1 - 2.2e-05 25.2 0.0 6.1e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESS70904.1 - 0.00062 19.0 0.3 0.0057 15.8 0.0 2.5 2 0 0 2 2 2 1 Chromatin associated protein KTI12 His_Phos_1 PF00300.17 ESS70904.1 - 0.0021 18.1 0.0 0.26 11.3 0.0 2.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_5 PF07728.9 ESS70904.1 - 0.0082 15.8 1.5 0.03 14.0 0.0 2.6 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) APS_kinase PF01583.15 ESS70904.1 - 0.0097 15.5 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase Zeta_toxin PF06414.7 ESS70904.1 - 0.029 13.4 0.0 0.06 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.1 ESS70904.1 - 0.082 13.0 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESS70904.1 - 0.093 12.9 0.0 0.32 11.1 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.20 ESS70906.1 - 1.5e-59 201.3 0.0 1.2e-38 132.7 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70906.1 - 6.2e-32 110.6 0.0 9.8e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70906.1 - 2.5e-06 26.6 0.0 8.4e-06 24.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Ubiquitin_2 PF14560.1 ESS70908.1 - 3.9e-12 46.2 0.0 7.3e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_4 PF12799.2 ESS70908.1 - 3e-10 39.4 4.6 0.015 14.8 0.7 4.1 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESS70908.1 - 9.3e-07 28.5 6.7 0.18 11.5 0.6 4.5 3 1 0 3 3 3 3 Leucine rich repeat LRR_9 PF14580.1 ESS70908.1 - 9.5e-05 22.0 1.1 0.34 10.4 0.0 3.6 2 1 0 3 3 3 2 Leucine-rich repeat ubiquitin PF00240.18 ESS70908.1 - 0.00056 19.2 0.0 0.0027 17.0 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family LRR_7 PF13504.1 ESS70908.1 - 0.0029 17.5 7.2 78 4.1 0.0 6.4 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.28 ESS70908.1 - 0.0056 16.5 5.1 12 6.3 0.0 5.9 6 1 1 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.1 ESS70908.1 - 0.091 12.8 7.3 46 4.5 0.0 5.9 6 0 0 6 6 6 0 Leucine Rich repeat RNase_Zc3h12a_2 PF14626.1 ESS70909.1 - 0.17 11.7 1.3 0.29 11.0 0.9 1.3 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain Beta_helix PF13229.1 ESS70913.1 - 6.7e-06 25.9 1.0 4.9e-05 23.1 0.5 2.2 2 0 0 2 2 2 1 Right handed beta helix region PGAP1 PF07819.8 ESS70915.1 - 1.2e-21 77.3 0.0 3.2e-21 75.9 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 ESS70915.1 - 3.1e-05 23.9 0.0 5.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS70915.1 - 0.00016 21.4 0.0 0.0003 20.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 ESS70915.1 - 0.00023 20.5 0.0 0.00054 19.3 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 ESS70915.1 - 0.00056 19.5 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF900 PF05990.7 ESS70915.1 - 0.029 13.6 0.0 0.056 12.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) MraY_sig1 PF10555.4 ESS70915.1 - 0.23 10.8 6.8 0.12 11.6 0.8 2.7 2 0 0 2 2 2 0 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 DEAD PF00270.24 ESS70916.1 - 1.2e-19 70.4 0.0 4.2e-19 68.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS70916.1 - 8.2e-07 28.8 0.2 3.5e-06 26.7 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESS70916.1 - 2.9e-06 27.2 0.1 0.00014 21.7 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.1 ESS70916.1 - 1.7 8.1 12.2 0.69 9.4 0.4 3.8 4 0 0 4 4 4 0 AAA domain AAA_14 PF13173.1 ESS70917.1 - 0.0034 17.2 0.0 0.0063 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS70917.1 - 0.0045 16.9 0.1 0.015 15.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 ESS70917.1 - 0.0086 15.7 0.0 0.065 12.9 0.0 2.0 2 0 0 2 2 2 1 Archaeal ATPase RecA PF00154.16 ESS70917.1 - 0.026 13.6 0.0 0.044 12.8 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_35 PF14516.1 ESS70917.1 - 0.04 12.5 0.0 0.076 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_25 PF13481.1 ESS70917.1 - 0.05 12.9 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESS70917.1 - 0.11 12.0 0.0 0.41 10.2 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain HTH_17 PF12728.2 ESS70917.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF843 PF05814.6 ESS70918.1 - 1 9.1 4.4 16 5.3 0.0 3.0 3 0 0 3 3 3 0 Baculovirus protein of unknown function (DUF843) TPR_12 PF13424.1 ESS70919.1 - 0.02 14.8 6.8 1.2 9.1 0.5 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat YbaB_DNA_bd PF02575.11 ESS70920.1 - 0.006 16.4 0.2 1.3 8.9 0.1 2.9 3 0 0 3 3 3 2 YbaB/EbfC DNA-binding family Exo_endo_phos PF03372.18 ESS70921.1 - 2.2e-17 63.8 0.6 4.8e-17 62.7 0.1 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Methyltransf_31 PF13847.1 ESS70922.1 - 1.1e-10 41.2 0.0 1.6e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS70922.1 - 1.6e-07 31.8 0.0 2.8e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESS70922.1 - 4.2e-07 29.5 0.0 7.6e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 ESS70922.1 - 2.9e-06 27.6 0.0 5.5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESS70922.1 - 4.7e-06 26.6 0.0 9.2e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESS70922.1 - 1.7e-05 24.0 0.0 2.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 ESS70922.1 - 0.00012 22.3 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS70922.1 - 0.0012 19.3 0.0 0.0023 18.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 ESS70922.1 - 0.0034 18.1 0.0 0.0065 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 ESS70922.1 - 0.0066 15.1 0.0 0.0099 14.5 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_4 PF02390.12 ESS70922.1 - 0.007 15.4 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.14 ESS70922.1 - 0.0077 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_PK PF05891.7 ESS70922.1 - 0.016 14.5 0.0 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase CMAS PF02353.15 ESS70922.1 - 0.023 13.7 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 ESS70922.1 - 0.039 13.6 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Response_reg PF00072.19 ESS70922.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Response regulator receiver domain Helicase_C_2 PF13307.1 ESS70923.1 - 2.8e-45 154.2 0.0 7.1e-45 152.9 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESS70923.1 - 9.7e-25 86.9 6.1 2.5e-19 69.3 1.5 3.6 3 1 0 3 3 3 2 DEAD_2 AAA_19 PF13245.1 ESS70923.1 - 0.0031 17.2 0.0 0.0098 15.6 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain DEAD PF00270.24 ESS70923.1 - 0.0085 15.5 0.0 0.035 13.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 ESS70923.1 - 0.024 14.4 0.0 0.35 10.6 0.0 2.6 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit Arrestin_N PF00339.24 ESS70925.1 - 3e-10 40.1 0.0 9.6e-10 38.4 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESS70925.1 - 0.016 15.2 0.2 3.2 7.8 0.0 2.8 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain ADH_zinc_N PF00107.21 ESS70927.1 - 1.6e-20 72.9 0.0 3e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESS70927.1 - 5.4e-20 72.5 0.0 1.1e-19 71.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESS70927.1 - 1.5e-11 44.0 0.1 2.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain YfhE PF14152.1 ESS70927.1 - 0.095 12.6 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 YfhE-like protein Lung_7-TM_R PF06814.8 ESS70928.1 - 0.03 13.2 10.3 0.32 9.9 0.0 2.7 2 1 0 2 2 2 0 Lung seven transmembrane receptor AAA PF00004.24 ESS70929.1 - 2.6e-43 147.3 0.2 6.3e-43 146.1 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESS70929.1 - 2.3e-07 31.0 0.3 0.00028 20.9 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 ESS70929.1 - 9.7e-07 28.9 0.2 0.00033 20.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESS70929.1 - 1.6e-06 27.9 0.1 1.3e-05 24.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESS70929.1 - 4.6e-06 26.6 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ESS70929.1 - 7.1e-06 25.2 0.7 2.7e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESS70929.1 - 2.6e-05 23.6 0.4 0.0029 17.0 0.1 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.8 ESS70929.1 - 0.00023 20.1 0.0 0.00051 19.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESS70929.1 - 0.00024 20.7 0.1 0.00068 19.3 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 ESS70929.1 - 0.00044 20.5 0.1 0.0019 18.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESS70929.1 - 0.00078 20.2 0.4 0.0022 18.8 0.1 2.0 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 ESS70929.1 - 0.00084 18.7 0.1 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESS70929.1 - 0.0012 18.7 0.0 0.0028 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESS70929.1 - 0.0016 17.2 0.0 0.0034 16.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus RNA_helicase PF00910.17 ESS70929.1 - 0.0018 18.4 0.0 0.0041 17.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 ESS70929.1 - 0.0024 17.0 0.0 0.0047 16.1 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.12 ESS70929.1 - 0.0036 16.2 0.0 0.0066 15.3 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_24 PF13479.1 ESS70929.1 - 0.0087 15.6 0.1 0.018 14.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 ESS70929.1 - 0.0087 15.6 0.0 0.033 13.7 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 ESS70929.1 - 0.011 14.8 1.8 0.14 11.2 0.0 3.1 2 2 1 4 4 4 0 KaiC Arch_ATPase PF01637.13 ESS70929.1 - 0.011 15.4 0.2 0.57 9.8 0.0 2.5 2 1 1 3 3 3 0 Archaeal ATPase AAA_33 PF13671.1 ESS70929.1 - 0.011 15.6 0.0 0.093 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESS70929.1 - 0.015 15.5 0.4 0.15 12.3 0.0 2.5 3 0 0 3 3 2 0 ABC transporter NACHT PF05729.7 ESS70929.1 - 0.019 14.6 0.1 0.11 12.1 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_28 PF13521.1 ESS70929.1 - 0.021 14.7 0.0 0.051 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESS70929.1 - 0.023 14.1 0.0 0.081 12.3 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.11 ESS70929.1 - 0.044 13.0 0.1 0.12 11.6 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein T2SE PF00437.15 ESS70929.1 - 0.05 12.4 0.1 0.13 11.1 0.0 1.7 1 1 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 ESS70929.1 - 0.052 12.6 0.1 0.13 11.3 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.1 ESS70929.1 - 0.071 12.6 0.1 0.39 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 ESS70929.1 - 0.077 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activ_2 PF14532.1 ESS70929.1 - 0.086 12.8 0.0 0.23 11.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_23 PF13476.1 ESS70929.1 - 1.3 9.2 4.1 3.6 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain TruD PF01142.13 ESS70930.1 - 0.0012 17.6 0.0 0.0021 16.7 0.0 1.3 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) RRM_1 PF00076.17 ESS70931.1 - 1.1e-13 50.5 0.2 1.6e-05 24.4 0.0 4.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS70931.1 - 8e-05 22.5 0.1 0.4 10.6 0.0 3.8 4 0 0 4 4 4 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS70931.1 - 0.00031 20.5 0.0 0.0076 16.0 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_F12L PF03337.8 ESS70931.1 - 0.075 10.9 0.0 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus F12L protein DSPc PF00782.15 ESS70932.1 - 0.00038 20.0 1.6 0.0014 18.2 0.5 2.3 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Ank_2 PF12796.2 ESS70934.1 - 2.5e-42 143.1 0.1 5.6e-16 58.6 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESS70934.1 - 4e-27 92.6 0.6 4.2e-06 26.2 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 ESS70934.1 - 1.4e-25 88.6 8.3 8.3e-08 32.2 0.3 5.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESS70934.1 - 2.5e-18 66.0 4.7 2.4e-07 31.0 0.1 4.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS70934.1 - 3.6e-17 60.7 0.7 0.026 14.7 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat zf-DHHC PF01529.15 ESS70934.1 - 0.00018 20.9 0.4 0.00018 20.9 0.3 2.5 3 0 0 3 3 3 1 DHHC palmitoyltransferase TLD PF07534.11 ESS70937.1 - 2.2e-21 76.2 0.2 3.9e-21 75.5 0.1 1.3 1 0 0 1 1 1 1 TLD MFS_1 PF07690.11 ESS70940.1 - 2.2e-26 92.4 10.6 2e-25 89.2 2.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 ESS70940.1 - 0.00049 18.2 0.0 0.00049 18.2 0.0 2.0 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF3682 PF12446.3 ESS70940.1 - 0.27 11.5 10.7 0.46 10.7 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) CAML PF14963.1 ESS70940.1 - 2 7.7 4.0 11 5.3 0.1 2.5 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand CLN3 PF02487.12 ESS70941.1 - 1.6e-32 112.8 39.5 6.8e-19 67.9 4.1 4.0 3 1 1 4 4 4 4 CLN3 protein RHSP PF07999.6 ESS70942.1 - 1.7e-44 152.1 0.1 2.3e-44 151.6 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Endonuclease_7 PF02945.10 ESS70943.1 - 0.93 9.2 4.2 1.4 8.6 2.9 1.2 1 0 0 1 1 1 0 Recombination endonuclease VII DUF3676 PF12429.3 ESS70944.1 - 1.7e-110 368.1 35.7 1.7e-110 368.1 24.7 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3676) Tr-sialidase_C PF11052.3 ESS70944.1 - 2.8e-09 36.6 4.0 4.4e-09 36.0 2.8 1.3 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal BNR_3 PF13859.1 ESS70945.1 - 1e-46 159.4 1.0 1.8e-46 158.6 0.1 1.7 2 0 0 2 2 2 1 BNR repeat-like domain Glycos_transf_2 PF00535.21 ESS70947.1 - 0.01 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESS70947.1 - 0.018 14.1 0.0 0.44 9.5 0.1 2.0 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESS70947.1 - 0.029 14.0 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family group 2 DUF4407 PF14362.1 ESS70949.1 - 0.019 13.9 4.7 0.032 13.1 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IFT57 PF10498.4 ESS70949.1 - 0.023 13.4 1.3 0.033 12.9 0.9 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.6 ESS70949.1 - 0.12 10.9 0.7 0.18 10.4 0.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Grp1_Fun34_YaaH PF01184.14 ESS70950.1 - 4.3e-38 130.7 10.6 5.3e-38 130.4 7.4 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Grp1_Fun34_YaaH PF01184.14 ESS70951.1 - 5.4e-38 130.4 14.5 7.4e-38 129.9 10.1 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Pkinase PF00069.20 ESS70952.1 - 3.8e-37 127.8 0.0 7e-30 104.0 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESS70952.1 - 1.8e-13 50.1 0.0 3.3e-12 46.0 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS70952.1 - 0.003 16.5 0.0 0.0052 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DDRGK PF09756.4 ESS70953.1 - 6.8e-24 84.3 37.5 5.3e-18 65.1 1.6 2.3 1 1 1 2 2 2 2 DDRGK domain Ycf1 PF05758.7 ESS70953.1 - 0.64 7.6 11.0 0.8 7.3 7.6 1.1 1 0 0 1 1 1 0 Ycf1 LMBR1 PF04791.11 ESS70953.1 - 1.1 7.8 5.1 2.3 6.6 3.5 1.6 1 1 0 1 1 1 0 LMBR1-like membrane protein Borrelia_P83 PF05262.6 ESS70953.1 - 2.7 6.1 16.0 4.1 5.5 11.1 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Hid1 PF12722.2 ESS70953.1 - 4.6 4.7 6.7 5.4 4.5 4.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BNR_3 PF13859.1 ESS70956.1 - 7.7e-74 248.5 1.3 1.6e-73 247.5 0.6 1.6 2 0 0 2 2 2 1 BNR repeat-like domain Condensation PF00668.15 ESS70958.1 - 0.067 12.0 0.1 0.072 11.9 0.1 1.1 1 0 0 1 1 1 0 Condensation domain Pyrophosphatase PF00719.14 ESS70959.1 - 1.5e-46 157.7 0.0 1.8e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Ribosomal_L39 PF00832.15 ESS70960.1 - 3.9e-20 71.0 14.1 4.3e-20 70.8 9.8 1.0 1 0 0 1 1 1 1 Ribosomal L39 protein Methyltransf_FA PF12248.3 ESS70960.1 - 0.043 13.8 0.0 0.046 13.7 0.0 1.1 1 0 0 1 1 1 0 Farnesoic acid 0-methyl transferase HSP20 PF00011.16 ESS70962.1 - 3.9e-19 68.3 0.1 4.5e-19 68.1 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Peptidase_S32 PF05579.8 ESS70965.1 - 0.00024 20.1 0.2 0.00037 19.5 0.1 1.3 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 Trypsin_2 PF13365.1 ESS70965.1 - 0.007 16.3 0.5 0.013 15.4 0.3 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.10 ESS70965.1 - 0.028 13.9 0.6 0.051 13.1 0.4 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Snapin_Pallidin PF14712.1 ESS70966.1 - 0.00098 19.3 3.5 0.0013 18.9 1.6 1.8 1 1 1 2 2 2 2 Snapin/Pallidin TelA PF05816.6 ESS70966.1 - 0.0035 16.1 0.2 0.0046 15.7 0.1 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) KBP_C PF12309.3 ESS70966.1 - 0.016 14.2 0.4 0.018 14.0 0.3 1.1 1 0 0 1 1 1 0 KIF-1 binding protein C terminal DUF4131 PF13567.1 ESS70967.1 - 5.5 6.3 9.9 4.6 6.5 1.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Shisa PF13908.1 ESS70968.1 - 0.099 12.8 1.3 0.3 11.2 0.9 1.8 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator PgaD PF13994.1 ESS70968.1 - 0.39 10.1 4.3 0.64 9.4 3.0 1.2 1 0 0 1 1 1 0 PgaD-like protein PH PF00169.24 ESS70970.1 - 4.1e-06 26.9 0.2 9.3e-06 25.7 0.0 1.7 2 0 0 2 2 2 1 PH domain ERM PF00769.14 ESS70970.1 - 0.00054 19.5 1.7 0.00077 19.0 1.2 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Metal_resist PF13801.1 ESS70970.1 - 0.0027 17.6 1.1 0.0064 16.4 0.8 1.5 1 1 0 1 1 1 1 Heavy-metal resistance DUF955 PF06114.8 ESS70970.1 - 0.018 14.7 0.7 0.029 14.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF955) KLRAQ PF10205.4 ESS70970.1 - 0.046 13.7 5.7 1.2 9.2 2.5 2.2 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF1570 PF07607.6 ESS70970.1 - 0.06 13.3 0.7 0.15 12.0 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1570) ATP-synt_E PF05680.7 ESS70970.1 - 0.34 10.8 2.7 0.61 10.0 1.9 1.4 1 0 0 1 1 1 0 ATP synthase E chain ParcG PF10274.4 ESS71007.1 - 3e-76 255.4 0.1 3.6e-76 255.1 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein WD40 PF00400.27 ESS71009.1 - 2.4e-35 119.1 0.5 4.6e-10 38.9 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.3 ESS71009.1 - 0.00013 20.2 0.3 0.0037 15.4 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.6 ESS71009.1 - 0.0059 16.3 0.0 9.2 5.9 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 ESS71009.1 - 0.042 12.5 0.0 2.2 6.9 0.0 2.3 1 1 0 2 2 2 0 Nup133 N terminal like zf-SNAP50_C PF12251.3 ESS71010.1 - 1.7e-60 203.7 0.2 2.3e-60 203.3 0.1 1.1 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal LysM PF01476.15 ESS71010.1 - 0.0003 20.6 0.0 0.00066 19.5 0.0 1.6 1 0 0 1 1 1 1 LysM domain DMPK_coil PF08826.5 ESS71010.1 - 0.089 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 DMPK coiled coil domain like DSPc PF00782.15 ESS71011.1 - 1e-20 73.6 0.1 1.3e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESS71011.1 - 0.00078 18.8 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.7 ESS71011.1 - 0.13 11.1 0.0 0.15 10.9 0.0 1.0 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase DnaJ PF00226.26 ESS71012.1 - 2.3e-15 56.0 0.4 5.2e-15 54.9 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain Kei1 PF08552.6 ESS71012.1 - 0.089 12.4 0.1 0.44 10.1 0.0 2.0 2 1 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Pkinase PF00069.20 ESS71013.1 - 8.5e-10 38.2 0.0 3e-05 23.2 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESS71013.1 - 0.0016 17.5 0.0 0.0027 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase 60KD_IMP PF02096.15 ESS71014.1 - 6.1e-15 55.4 0.0 9.2e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein LT-IIB PF06453.6 ESS71015.1 - 0.0037 16.9 0.0 0.0051 16.4 0.0 1.2 1 0 0 1 1 1 1 Type II heat-labile enterotoxin , B subunit (LT-IIB) Robl_LC7 PF03259.12 ESS71015.1 - 0.0061 16.1 0.2 0.24 10.9 0.2 2.4 1 1 0 1 1 1 1 Roadblock/LC7 domain zf-HC5HC2H PF13771.1 ESS71016.1 - 2.6e-18 65.9 7.6 9.1e-18 64.2 3.4 2.2 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESS71016.1 - 1.4e-14 54.0 8.7 2.2e-14 53.3 6.0 1.3 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD PF00628.24 ESS71016.1 - 4.1 7.1 9.3 0.43 10.2 1.7 2.5 2 1 0 2 2 2 0 PHD-finger Herpes_BLRF2 PF05812.7 ESS71018.1 - 0.039 13.7 0.4 0.039 13.7 0.3 5.3 4 2 1 5 5 5 0 Herpesvirus BLRF2 protein Sin3_corepress PF08295.7 ESS71018.1 - 1.9 8.3 9.6 0.39 10.4 0.6 3.5 3 1 0 3 3 3 0 Sin3 family co-repressor Occludin_ELL PF07303.8 ESS71018.1 - 7.9 7.2 20.7 1.5 9.6 1.2 4.4 2 2 2 4 4 4 0 Occludin homology domain IncA PF04156.9 ESS71018.1 - 8.3 5.9 49.4 11 5.5 8.2 4.4 2 1 2 4 4 4 0 IncA protein PS_Dcarbxylase PF02666.10 ESS71019.1 - 2.1e-41 141.4 0.0 2.6e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.1 ESS71019.1 - 0.094 12.3 0.5 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Biotin-lipoyl like SET PF00856.23 ESS71020.1 - 2.9e-30 105.7 9.4 8.2e-05 22.9 0.0 9.9 9 1 1 10 10 10 6 SET domain SAF PF08666.7 ESS71020.1 - 2.6e-05 24.5 0.0 12 6.3 0.0 8.5 12 0 0 12 12 12 1 SAF domain FPL PF09758.4 ESS71021.1 - 1.5e-55 187.0 3.3 2.7e-55 186.2 2.3 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein ICMT PF04140.9 ESS71021.1 - 1.1 9.5 6.0 0.65 10.2 0.3 2.6 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF563 PF04577.9 ESS71022.1 - 1.9e-35 122.6 1.6 2.9e-35 122.0 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) HLH PF00010.21 ESS71022.1 - 0.14 11.9 1.0 3.3 7.4 0.0 2.9 3 0 0 3 3 3 0 Helix-loop-helix DNA-binding domain DUF1129 PF06570.6 ESS71024.1 - 0.43 9.8 3.1 0.18 11.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF2613 PF11021.3 ESS71024.1 - 0.46 10.2 2.8 32 4.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) CS PF04969.11 ESS71025.1 - 1.4e-07 31.9 0.1 2.4e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 CS domain Mito_carr PF00153.22 ESS71029.1 - 3.1e-33 113.3 8.9 2.7e-20 71.8 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein AA_permease_2 PF13520.1 ESS71030.1 - 4.7e-33 114.3 33.3 5.7e-33 114.0 23.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESS71030.1 - 4.3e-12 45.1 28.8 9e-12 44.0 20.0 1.4 1 1 0 1 1 1 1 Amino acid permease Pkinase PF00069.20 ESS71031.1 - 1.1e-61 208.2 0.0 1.6e-61 207.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS71031.1 - 4.6e-41 140.6 0.0 6.8e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESS71031.1 - 0.00082 19.1 0.1 0.086 12.5 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ESS71031.1 - 0.0021 17.0 0.0 0.0035 16.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESS71031.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.6 ESS71031.1 - 0.24 10.2 0.0 0.39 9.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 TPR_12 PF13424.1 ESS71032.1 - 0.00017 21.4 7.2 0.16 11.9 1.6 3.8 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.1 ESS71032.1 - 0.0002 20.9 1.9 0.075 12.6 0.7 3.3 3 1 0 3 3 3 2 TPR repeat zf-C3HC4_3 PF13920.1 ESS71033.1 - 6.1e-09 35.4 7.4 1.4e-08 34.2 5.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS71033.1 - 9e-07 28.6 10.9 2.1e-06 27.4 7.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESS71033.1 - 2.7e-06 27.2 11.4 2.7e-06 27.2 7.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESS71033.1 - 3.5e-05 23.3 7.2 6.8e-05 22.4 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESS71033.1 - 4.8e-05 22.9 7.3 0.00017 21.2 5.1 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.1 ESS71033.1 - 0.38 10.3 8.4 0.98 9.0 5.8 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Ion_trans_2 PF07885.11 ESS71033.1 - 0.56 9.9 5.4 14 5.5 0.9 3.3 2 1 0 2 2 2 0 Ion channel FYVE PF01363.16 ESS71033.1 - 0.72 9.7 7.5 3.8 7.4 5.3 1.9 1 1 0 1 1 1 0 FYVE zinc finger DUF1272 PF06906.6 ESS71033.1 - 1.2 9.0 5.9 12 5.8 4.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) DNA_pol_B_exo1 PF03104.14 ESS71034.1 - 1.8e-51 174.9 0.2 3.4e-51 174.0 0.2 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.7 ESS71034.1 - 1.2e-47 162.3 0.0 2.5e-46 158.0 0.0 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.16 ESS71034.1 - 1.1e-17 63.9 0.2 4.5e-15 55.3 0.0 3.5 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 ESS71034.1 - 6.4e-09 35.6 1.7 1.1e-07 31.6 0.5 2.8 2 1 0 2 2 2 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 ESS71034.1 - 2.2e-07 30.8 0.2 1.2e-06 28.4 0.1 2.3 2 1 0 2 2 2 1 RNase_H superfamily DUF348 PF03990.9 ESS71034.1 - 0.13 11.8 0.1 0.33 10.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF348) PGAP1 PF07819.8 ESS71036.1 - 3e-09 36.8 0.0 8.8e-06 25.4 0.0 2.7 2 1 0 2 2 2 2 PGAP1-like protein Abhydrolase_6 PF12697.2 ESS71036.1 - 0.00017 21.5 0.3 0.0018 18.2 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family PIH1 PF08190.7 ESS71039.1 - 4.6e-109 364.8 0.0 8.8e-109 363.9 0.0 1.5 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Hydrolase_6 PF13344.1 ESS71040.1 - 1.7e-19 69.5 0.0 3.6e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESS71040.1 - 5.6e-11 42.0 0.0 1.2e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Reo_sigmaC PF04582.7 ESS71043.1 - 0.00083 18.6 2.7 0.00083 18.6 1.9 3.5 1 1 1 3 3 3 2 Reovirus sigma C capsid protein DUF4201 PF13870.1 ESS71043.1 - 1.1 8.6 41.1 0.95 8.8 16.4 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4201) ATG16 PF08614.6 ESS71043.1 - 2 8.1 50.3 5 6.8 10.2 4.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) AAA_27 PF13514.1 ESS71043.1 - 4.7 4.7 48.8 0.41 8.2 17.1 2.7 1 1 0 2 2 2 0 AAA domain Methyltransf_23 PF13489.1 ESS71044.1 - 1.4e-23 83.4 0.0 5.6e-23 81.4 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS71044.1 - 1.1e-18 67.3 0.1 2.8e-18 65.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS71044.1 - 1.9e-18 66.6 0.1 3.6e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS71044.1 - 1.4e-14 54.6 0.1 2e-14 54.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS71044.1 - 4.1e-14 52.8 0.1 8.1e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESS71044.1 - 8.2e-12 44.7 0.0 1.5e-11 43.8 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 ESS71044.1 - 1.5e-09 37.9 0.0 2.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS71044.1 - 1.2e-08 35.2 0.5 3e-08 33.9 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESS71044.1 - 4.9e-08 32.4 0.0 7.3e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.6 ESS71044.1 - 4.4e-06 26.2 0.1 6.7e-05 22.3 0.1 2.0 1 1 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.9 ESS71044.1 - 6.9e-06 25.3 0.0 3.1e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.1 ESS71044.1 - 1.1e-05 25.0 0.0 2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESS71044.1 - 3.2e-05 23.1 0.0 5.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 ESS71044.1 - 0.00011 21.6 0.1 0.00017 21.0 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 ESS71044.1 - 0.00029 20.4 0.1 0.00049 19.6 0.1 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pox_MCEL PF03291.11 ESS71044.1 - 0.0005 19.0 0.0 0.00077 18.4 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme MetW PF07021.7 ESS71044.1 - 0.00091 18.6 2.1 0.0068 15.7 1.4 2.0 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW DREV PF05219.7 ESS71044.1 - 0.0022 16.8 0.0 0.0052 15.6 0.0 1.5 1 1 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.15 ESS71044.1 - 0.035 13.1 0.0 0.053 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TPMT PF05724.6 ESS71044.1 - 0.091 12.1 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.7 ESS71046.1 - 0.017 15.5 0.0 0.052 14.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Syja_N PF02383.13 ESS71047.1 - 5.6e-47 160.0 0.0 9.8e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Oxidored_FMN PF00724.15 ESS71049.1 - 7e-68 229.1 0.0 1.3e-67 228.2 0.0 1.4 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Nucleotid_trans PF03407.11 ESS71050.1 - 1.8e-53 181.4 0.0 2.6e-53 180.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase BBS1 PF14779.1 ESS71051.1 - 3.5e-61 206.4 0.0 5.9e-61 205.6 0.0 1.3 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 1 BBS2_Mid PF14783.1 ESS71051.1 - 2.2e-05 24.2 0.0 0.32 10.8 0.0 3.0 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF3363 PF11843.3 ESS71051.1 - 0.027 13.1 0.0 0.043 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3363) PHTB1_N PF14727.1 ESS71051.1 - 0.04 12.8 0.0 0.32 9.8 0.0 2.3 3 0 0 3 3 3 0 PTHB1 N-terminus RNA_pol_Rpc4 PF05132.9 ESS71052.1 - 5.2e-11 42.6 0.3 1.4e-09 38.0 0.0 2.6 2 1 1 3 3 3 1 RNA polymerase III RPC4 DUF2009 PF09418.5 ESS71053.1 - 2.4e-213 709.0 0.0 2.7e-213 708.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) GTP_EFTU PF00009.22 ESS71054.1 - 3.3e-43 147.3 0.0 2.1e-42 144.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESS71054.1 - 1.5e-06 28.2 0.3 3.3e-06 27.2 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.18 ESS71054.1 - 0.00037 20.4 0.0 0.00092 19.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS71054.1 - 0.00089 18.5 0.2 0.0025 17.1 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B G-alpha PF00503.15 ESS71054.1 - 0.035 12.7 0.1 0.061 12.0 0.1 1.4 1 0 0 1 1 1 0 G-protein alpha subunit HBS1_N PF08938.5 ESS71054.1 - 0.057 13.5 0.0 0.057 13.5 0.0 2.6 2 0 0 2 2 2 0 HBS1 N-terminus PBP1_TM PF14812.1 ESS71054.1 - 0.34 11.2 4.3 0.76 10.1 3.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mucin PF01456.12 ESS71055.1 - 0.02 14.7 2.2 0.034 13.9 1.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2207 PF09972.4 ESS71055.1 - 2.8 6.4 4.2 4 5.8 2.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RRM_1 PF00076.17 ESS71056.1 - 2.3e-72 238.5 0.0 1.6e-16 59.6 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESS71056.1 - 7.8e-49 163.5 0.0 2.5e-11 43.3 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 ESS71056.1 - 2.7e-27 94.2 0.5 5e-27 93.3 0.4 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.1 ESS71056.1 - 1.7e-25 88.6 0.1 2.9e-06 27.0 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESS71056.1 - 1.1e-08 34.9 6.0 0.089 12.6 0.5 4.4 2 1 2 4 4 4 4 RNA binding motif Nup35_RRM_2 PF14605.1 ESS71056.1 - 2.4e-08 33.6 0.0 0.19 11.4 0.0 4.7 5 0 0 5 5 5 3 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 ESS71056.1 - 6.4e-07 29.0 0.1 0.056 13.1 0.0 4.4 3 1 1 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 ESS71056.1 - 3.8e-05 23.3 3.6 0.011 15.5 0.0 4.3 4 3 0 4 4 4 1 Limkain b1 SseB PF07179.7 ESS71060.1 - 0.031 14.0 0.0 6 6.7 0.0 2.4 2 0 0 2 2 2 0 SseB protein N-terminal domain TPR_16 PF13432.1 ESS71062.1 - 4e-15 56.0 13.6 3.2e-05 24.4 0.4 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESS71062.1 - 2.2e-13 49.6 12.7 0.00014 21.4 0.1 4.9 3 2 0 4 4 4 4 TPR repeat TPR_19 PF14559.1 ESS71062.1 - 7.5e-12 45.4 6.9 6.8e-06 26.3 0.1 4.0 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESS71062.1 - 1.6e-10 40.0 10.8 0.19 11.7 0.0 6.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESS71062.1 - 6.6e-09 35.6 14.4 0.00089 19.6 0.1 6.3 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESS71062.1 - 3.9e-08 32.5 1.4 1.4 8.6 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESS71062.1 - 4.1e-08 32.7 9.2 0.52 10.6 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESS71062.1 - 7.5e-07 28.4 1.3 1 9.2 0.0 5.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESS71062.1 - 1.3e-06 28.2 15.3 0.39 10.6 0.8 5.3 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.1 ESS71062.1 - 0.0011 18.6 10.5 0.48 10.3 0.0 5.5 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESS71062.1 - 0.0027 16.8 6.0 0.099 11.6 0.1 3.4 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESS71062.1 - 0.0042 17.4 7.6 11 6.7 0.0 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat NARP1 PF12569.3 ESS71062.1 - 0.014 14.2 0.3 0.058 12.1 0.1 1.9 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_4 PF07721.9 ESS71062.1 - 0.019 15.3 3.2 5.2 7.7 0.0 4.5 4 1 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESS71062.1 - 0.82 9.5 7.1 1.4 8.8 0.3 3.8 2 2 2 4 4 4 0 Tetratricopeptide repeat DUF1840 PF08895.6 ESS71062.1 - 2.2 8.3 5.9 1.9 8.5 0.0 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF1840) RIIa PF02197.12 ESS71063.1 - 9.9e-12 44.0 0.1 2.7e-11 42.6 0.1 1.8 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_7 PF13499.1 ESS71063.1 - 7e-06 26.0 0.1 8.6e-05 22.5 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESS71063.1 - 0.00097 18.8 0.1 0.14 12.1 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 ESS71063.1 - 0.012 14.8 0.2 0.11 11.8 0.0 2.6 3 0 0 3 3 3 0 EF hand Pkinase PF00069.20 ESS71064.1 - 6.1e-39 133.7 0.0 1e-38 133.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS71064.1 - 1.2e-20 73.7 0.0 2.2e-20 72.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS71064.1 - 1.4e-06 27.5 0.0 2.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESS71064.1 - 0.015 15.0 0.1 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Corona_nucleoca PF00937.13 ESS71064.1 - 0.091 11.6 5.5 0.16 10.9 3.8 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Seadorna_VP7 PF07387.6 ESS71064.1 - 0.12 11.2 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 zf-RING_4 PF14570.1 ESS71064.1 - 4.6 6.8 14.6 9.2 5.9 10.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DnaJ PF00226.26 ESS71065.1 - 1.1e-18 66.6 0.2 1.9e-18 65.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain PurS PF02700.9 ESS71065.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase DEAD PF00270.24 ESS71066.1 - 1.1e-32 112.8 0.0 2.3e-32 111.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS71066.1 - 1.4e-21 76.1 1.5 2.3e-21 75.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESS71066.1 - 1.5e-17 62.9 0.0 3.9e-17 61.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESS71066.1 - 0.079 12.7 0.1 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Abhydrolase_5 PF12695.2 ESS71067.1 - 1.2e-22 80.2 0.0 2.1e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS71067.1 - 2.9e-18 66.5 0.0 1e-17 64.7 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESS71067.1 - 1.1e-09 38.1 0.0 0.00017 21.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.7 ESS71067.1 - 6.6e-07 28.1 0.0 5e-06 25.2 0.0 2.2 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) DLH PF01738.13 ESS71067.1 - 9.2e-07 28.3 0.0 0.019 14.2 0.0 2.4 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 ESS71067.1 - 3.7e-06 26.5 0.0 0.018 14.4 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.8 ESS71067.1 - 1.7e-05 24.5 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESS71067.1 - 2.4e-05 23.6 0.0 0.00019 20.7 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.6 ESS71067.1 - 0.00013 21.7 0.0 0.0012 18.6 0.0 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.8 ESS71067.1 - 0.0023 17.4 0.0 0.0039 16.6 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DUF1100 PF06500.6 ESS71067.1 - 0.0037 15.8 0.0 0.0068 15.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Hydrolase_4 PF12146.3 ESS71067.1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase Ras PF00071.17 ESS71068.1 - 3.9e-53 179.1 1.6 2.2e-52 176.6 1.1 1.9 1 1 0 1 1 1 1 Ras family Miro PF08477.8 ESS71068.1 - 3.5e-22 79.1 0.0 7e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESS71068.1 - 8.7e-13 47.8 0.0 1.2e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESS71068.1 - 6.9e-07 28.6 0.0 9e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESS71068.1 - 4.6e-06 26.5 0.0 7.7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESS71068.1 - 0.00048 19.6 0.0 0.0078 15.6 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.14 ESS71068.1 - 0.0021 17.5 0.1 2.1 7.7 0.0 2.4 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 ESS71068.1 - 0.0033 17.5 0.0 0.0057 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESS71068.1 - 0.016 14.9 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase DUF258 PF03193.11 ESS71068.1 - 0.017 14.3 0.1 0.061 12.4 0.1 1.8 1 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 ESS71068.1 - 0.018 14.6 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 ESS71068.1 - 0.031 13.7 0.1 0.12 11.8 0.0 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 ESS71068.1 - 0.033 14.1 0.1 0.053 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain MobB PF03205.9 ESS71068.1 - 0.057 13.1 0.0 0.16 11.6 0.0 1.8 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ESS71068.1 - 0.071 12.5 0.0 0.13 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain NACHT PF05729.7 ESS71068.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.10 ESS71068.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 NTPase PrgI PF12666.2 ESS71068.1 - 5 7.3 9.3 38 4.5 0.0 3.0 2 1 0 2 2 2 0 PrgI family protein Mito_carr PF00153.22 ESS71069.1 - 3.6e-62 206.0 4.1 1.2e-20 72.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-MIZ PF02891.15 ESS71072.1 - 4.6e-19 67.6 9.5 1.1e-18 66.4 6.6 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-rbx1 PF12678.2 ESS71072.1 - 0.0044 17.1 2.1 0.011 15.8 1.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Nse PF11789.3 ESS71072.1 - 0.08 12.4 2.9 0.2 11.1 2.0 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESS71072.1 - 0.12 12.1 6.5 0.33 10.7 4.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.20 ESS71072.1 - 0.64 9.7 10.3 1.5 8.5 7.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESS71072.1 - 0.81 9.7 11.4 2.7 8.0 7.9 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESS71072.1 - 1 9.2 10.5 3.2 7.6 7.3 2.0 1 0 0 1 1 1 0 Ring finger domain PROCN PF08083.6 ESS71073.1 - 1.2e-177 590.4 8.6 2.6e-177 589.3 6.0 1.5 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 ESS71073.1 - 4.3e-91 304.3 0.0 7e-91 303.6 0.0 1.3 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 ESS71073.1 - 4e-67 224.5 0.0 9.6e-67 223.3 0.0 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.4 ESS71073.1 - 3e-55 185.5 0.4 1.6e-54 183.1 0.0 2.4 2 0 0 2 2 2 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.4 ESS71073.1 - 1.3e-35 121.1 0.0 3e-35 119.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.6 ESS71073.1 - 1.4e-25 89.3 0.0 3.1e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain Big_2 PF02368.13 ESS71073.1 - 0.53 10.2 3.4 0.18 11.6 0.2 1.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 2) PRO8NT PF08082.6 ESS71074.1 - 3.2e-48 163.2 0.5 4.7e-48 162.6 0.3 1.2 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain INCENP_N PF12178.3 ESS71076.1 - 6.7e-18 63.9 0.1 1.2e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Chromosome passenger complex (CPC) protein INCENP N terminal UNC-50 PF05216.8 ESS71077.1 - 8.4e-83 277.1 11.9 1e-82 276.8 8.2 1.0 1 0 0 1 1 1 1 UNC-50 family SID-1_RNA_chan PF13965.1 ESS71077.1 - 0.72 7.9 8.0 0.91 7.6 5.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4191 PF13829.1 ESS71077.1 - 2.9 6.9 5.0 0.52 9.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) SHIPPO-rpt PF07004.7 ESS71078.1 - 2.7e-17 62.6 54.9 0.0045 17.8 0.2 10.3 10 0 0 10 10 10 9 Sperm-tail PG-rich repeat DZR PF12773.2 ESS71079.1 - 0.0074 16.0 0.3 0.025 14.3 0.2 1.8 1 0 0 1 1 1 1 Double zinc ribbon WD40 PF00400.27 ESS71081.1 - 1.4e-35 119.8 22.6 2e-10 40.1 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat Sof1 PF04158.9 ESS71081.1 - 1.2e-11 44.4 3.5 2.3e-11 43.5 2.4 1.4 1 0 0 1 1 1 1 Sof1-like domain eIF2A PF08662.6 ESS71081.1 - 0.00028 20.6 0.2 0.0007 19.3 0.1 1.7 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A NDK PF00334.14 ESS71082.1 - 1.6e-32 112.0 0.0 4.2e-30 104.2 0.0 2.3 2 0 0 2 2 2 2 Nucleoside diphosphate kinase Cpn60_TCP1 PF00118.19 ESS71083.1 - 1.5e-147 492.1 0.7 1.7e-147 491.9 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_S17 PF00366.15 ESS71084.1 - 3.3e-15 55.8 0.4 3.3e-15 55.8 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein S17 Rubella_E1 PF05748.6 ESS71084.1 - 0.087 11.4 0.0 0.18 10.3 0.0 1.4 2 0 0 2 2 2 0 Rubella membrane glycoprotein E1 Proteasome PF00227.21 ESS71085.1 - 3.7e-50 169.8 0.3 4.6e-50 169.5 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 ESS71085.1 - 7.4e-05 21.9 0.2 7.4e-05 21.9 0.1 1.9 2 0 0 2 2 2 1 Proteasome beta subunits C terminal DUF1375 PF07119.7 ESS71085.1 - 0.096 12.5 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1375) SPA PF08616.5 ESS71086.1 - 0.00049 19.7 0.0 0.002 17.8 0.0 2.0 2 0 0 2 2 2 1 Stabilization of polarity axis Afi1 PF07792.7 ESS71086.1 - 0.012 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DENN PF02141.16 ESS71086.1 - 0.033 13.9 0.3 1.1 8.9 0.0 2.6 3 0 0 3 3 3 0 DENN (AEX-3) domain SET PF00856.23 ESS71087.1 - 0.00033 21.0 0.0 0.033 14.4 0.0 2.2 2 0 0 2 2 2 2 SET domain PDGF PF00341.12 ESS71088.1 - 0.0032 17.5 0.1 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 PDGF/VEGF domain Spc42p PF11544.3 ESS71088.1 - 3.4 7.6 8.2 0.37 10.7 0.8 3.1 4 1 0 4 4 4 0 Spindle pole body component Spc42p TMA7 PF09072.5 ESS71088.1 - 4.7 7.7 5.2 4 7.9 0.3 2.8 3 0 0 3 3 3 0 Translation machinery associated TMA7 BLOC1_2 PF10046.4 ESS71088.1 - 7.4 6.7 9.5 2.5 8.2 0.0 3.6 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.7 ESS71088.1 - 7.8 6.2 31.9 1.7 8.3 3.2 4.4 3 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein Cullin PF00888.17 ESS71089.1 - 3.6e-16 58.8 0.0 5.7e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Cullin family DUF3391 PF11871.3 ESS71092.1 - 1.1 9.4 7.4 0.12 12.5 0.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3391) IKKbetaNEMObind PF12179.3 ESS71092.1 - 2.1 8.2 6.6 1.5 8.7 1.0 3.4 3 0 0 3 3 3 0 I-kappa-kinase-beta NEMO binding domain PEX11 PF05648.9 ESS71094.1 - 5.7e-14 51.9 0.0 1.3e-12 47.5 0.0 2.0 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DSPn PF14671.1 ESS71094.1 - 0.07 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half CheY-binding PF09078.6 ESS71094.1 - 0.096 12.7 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 CheY binding Ribul_P_3_epim PF00834.14 ESS71095.1 - 1.3e-55 187.6 0.0 1.6e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family GalKase_gal_bdg PF10509.4 ESS71096.1 - 2.1e-17 62.1 0.1 4e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 ESS71096.1 - 2.6e-07 30.7 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESS71096.1 - 5.2e-07 29.6 0.0 1.2e-05 25.2 0.0 2.9 2 1 1 3 3 3 1 GHMP kinases N terminal domain zf-RanBP PF00641.13 ESS71097.1 - 0.00048 19.1 2.4 0.00048 19.1 1.6 5.2 6 0 0 6 6 6 2 Zn-finger in Ran binding protein and others DZR PF12773.2 ESS71097.1 - 0.025 14.3 47.7 0.064 13.0 9.5 5.0 1 1 3 4 4 4 0 Double zinc ribbon DZR PF12773.2 ESS71098.1 - 1.2 8.9 51.0 0.064 13.0 6.4 5.6 2 2 3 5 5 5 0 Double zinc ribbon Methyltransf_23 PF13489.1 ESS71100.1 - 9.9e-24 83.8 0.0 1.5e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESS71100.1 - 2.8e-08 34.1 0.0 8.3e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESS71100.1 - 0.0002 21.7 0.0 0.00065 20.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESS71100.1 - 0.00024 21.6 0.0 0.00065 20.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESS71100.1 - 0.0017 17.9 0.0 0.0036 16.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESS71100.1 - 0.077 13.3 0.0 0.46 10.8 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain XPG_N PF00752.12 ESS71101.1 - 2.3e-22 79.1 0.0 5.4e-22 77.9 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 ESS71101.1 - 1.9e-20 72.7 0.2 4.5e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 ESS71101.1 - 3.6e-10 39.7 0.4 6.4e-10 38.9 0.3 1.5 1 0 0 1 1 1 1 XPG domain containing Ubiq_cyt_C_chap PF03981.7 ESS71101.1 - 0.0031 17.3 0.1 0.27 11.0 0.0 2.5 2 0 0 2 2 2 1 Ubiquinol-cytochrome C chaperone FUSC_2 PF13515.1 ESS71102.1 - 0.00017 21.4 7.2 0.00017 21.4 5.0 2.8 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.3 ESS71102.1 - 0.00098 17.8 3.4 0.33 9.5 0.0 2.3 2 0 0 2 2 2 2 Aluminium activated malate transporter MatE PF01554.13 ESS71103.1 - 1.4e-31 109.3 28.2 1.2e-18 67.2 6.0 2.3 2 0 0 2 2 2 2 MatE MatE PF01554.13 ESS71104.1 - 3e-31 108.2 25.5 3.1e-16 59.3 8.1 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 ESS71104.1 - 0.0025 17.6 6.1 0.0025 17.6 4.2 3.8 1 1 3 4 4 4 1 Polysaccharide biosynthesis C-terminal domain DUF3278 PF11683.3 ESS71104.1 - 8.5 6.3 10.1 0.53 10.2 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3278) CRAL_TRIO PF00650.15 ESS71105.1 - 8.4e-24 83.8 0.1 1.3e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESS71105.1 - 4.6e-10 39.4 1.7 5.2e-10 39.3 0.2 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain GATA PF00320.22 ESS71105.1 - 0.14 11.5 0.2 0.33 10.3 0.2 1.6 1 0 0 1 1 1 0 GATA zinc finger Baculo_PEP_C PF04513.7 ESS71106.1 - 0.24 11.2 5.9 5.6 6.7 0.2 3.7 3 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus SMC_N PF02463.14 ESS71107.1 - 2.4e-60 203.5 0.0 3.3e-59 199.7 0.0 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESS71107.1 - 1.7e-29 102.1 0.0 7.3e-29 100.1 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 ESS71107.1 - 2e-16 60.8 0.0 6.2e-07 29.6 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 ESS71107.1 - 5.2e-09 35.4 0.0 1e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 ESS71107.1 - 0.00091 19.6 43.4 0.00091 19.6 30.1 6.2 2 2 0 2 2 1 1 AAA domain AAA_15 PF13175.1 ESS71107.1 - 0.0072 15.4 15.3 0.021 13.9 0.0 4.1 4 1 0 4 4 4 1 AAA ATPase domain Reo_sigmaC PF04582.7 ESS71107.1 - 0.011 14.8 17.4 0.068 12.3 0.7 4.7 5 0 0 5 5 5 0 Reovirus sigma C capsid protein AAA_5 PF07728.9 ESS71107.1 - 0.024 14.3 4.7 3 7.5 0.0 3.6 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.18 ESS71107.1 - 0.042 13.7 0.6 2.5 8.0 0.0 3.9 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA_25 PF13481.1 ESS71107.1 - 0.1 12.0 0.0 0.1 12.0 0.0 3.6 4 1 0 4 4 4 0 AAA domain ABC_tran PF00005.22 ESS71107.1 - 0.77 10.0 34.4 25 5.1 0.0 6.5 3 3 0 3 3 2 0 ABC transporter Bul1_N PF04425.7 ESS71108.1 - 0.04 12.4 1.0 0.063 11.8 0.7 1.2 1 0 0 1 1 1 0 Bul1 N terminus FYVE PF01363.16 ESS71109.1 - 2e-19 69.2 13.7 2.8e-19 68.7 9.5 1.2 1 0 0 1 1 1 1 FYVE zinc finger Elf1 PF05129.8 ESS71109.1 - 0.6 9.8 4.5 0.95 9.1 3.1 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like IBR PF01485.16 ESS71109.1 - 2.8 7.8 12.3 0.82 9.5 6.2 1.8 2 0 0 2 2 2 0 IBR domain FYVE_2 PF02318.11 ESS71109.1 - 4.3 7.2 7.1 9.3 6.1 4.9 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger FeThRed_B PF02943.10 ESS71110.1 - 0.15 11.7 4.3 0.32 10.7 3.0 1.5 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain Acyl_transf_1 PF00698.16 ESS71111.1 - 6.4e-22 78.2 0.1 1.1e-21 77.5 0.1 1.4 1 1 0 1 1 1 1 Acyl transferase domain Herpes_IE2_3 PF03361.9 ESS71111.1 - 0.075 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 peroxidase PF00141.18 ESS71113.1 - 9.2e-10 38.3 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Peroxidase HrpE PF06188.7 ESS71113.1 - 0.045 13.5 3.9 0.075 12.7 2.7 1.3 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E BHD_3 PF10405.4 ESS71115.1 - 3.2e-20 71.5 0.0 5.1e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 ESS71115.1 - 1.1e-14 53.6 0.1 1.7e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 ESS71115.1 - 1.6e-09 37.9 0.1 1.8e-08 34.5 0.0 2.7 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Rad4 PF03835.10 ESS71115.1 - 1.2e-05 24.7 1.7 1.2e-05 24.7 1.2 1.8 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Ribosomal_L36e PF01158.13 ESS71116.1 - 0.023 14.6 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L36e CDC50 PF03381.10 ESS71117.1 - 2.9e-85 285.8 0.0 3.9e-85 285.3 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Dak1 PF02733.12 ESS71118.1 - 9.2e-84 280.7 0.9 1.3e-83 280.3 0.6 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 ESS71118.1 - 5.5e-40 136.8 2.8 1.1e-39 135.8 1.9 1.6 1 0 0 1 1 1 1 DAK2 domain PARP_regulatory PF01358.13 ESS71119.1 - 1.2e-17 63.5 0.0 8.7e-12 44.2 0.0 2.2 2 0 0 2 2 2 2 Poly A polymerase regulatory subunit DUF2428 PF10350.4 ESS71121.1 - 1.3e-59 201.3 0.0 2.5e-59 200.3 0.0 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 ESS71121.1 - 0.00046 20.0 3.2 3.2 8.0 0.1 5.6 5 0 0 5 5 5 2 HEAT repeat TP_methylase PF00590.15 ESS71122.1 - 1.5e-20 73.7 0.3 5.1e-20 72.0 0.1 2.0 2 1 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases 6PGD PF00393.14 ESS71123.1 - 5.4e-88 294.9 0.0 9e-88 294.2 0.0 1.3 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 ESS71123.1 - 8.9e-46 155.7 0.6 1.4e-45 155.0 0.4 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 ESS71123.1 - 1.4e-05 25.2 0.2 4.7e-05 23.5 0.1 1.9 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 ESS71123.1 - 2.3e-05 24.1 0.1 4e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.12 ESS71123.1 - 3.9e-05 24.0 0.6 8.3e-05 22.9 0.4 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 ESS71123.1 - 0.00045 19.9 0.1 0.00083 19.1 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 ESS71123.1 - 0.00092 18.6 0.1 0.0016 17.8 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_11 PF14833.1 ESS71123.1 - 0.0018 18.3 0.1 0.0041 17.1 0.1 1.6 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DAO PF01266.19 ESS71123.1 - 0.0049 15.8 0.0 0.0084 15.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.14 ESS71123.1 - 0.012 14.7 0.1 0.026 13.6 0.1 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 ESS71123.1 - 0.045 13.1 0.2 0.085 12.2 0.2 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.7 ESS71123.1 - 0.075 12.4 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 ESS71123.1 - 0.099 12.6 0.3 0.18 11.7 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain Mito_carr PF00153.22 ESS71124.1 - 3.8e-54 180.3 0.9 8.3e-22 76.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1632 PF07857.7 ESS71124.1 - 0.022 14.0 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 CEO family (DUF1632) LRR_4 PF12799.2 ESS71126.1 - 9.2e-09 34.7 6.7 7e-06 25.5 1.3 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESS71126.1 - 1.1e-07 31.5 0.4 2.4e-07 30.4 0.3 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 ESS71126.1 - 1.4e-05 24.7 10.4 0.00077 19.1 0.6 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.1 ESS71126.1 - 0.00083 19.1 0.8 2 8.7 0.2 4.4 3 1 1 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.28 ESS71126.1 - 0.13 12.3 6.0 15 6.0 0.5 4.1 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_7 PF13504.1 ESS71126.1 - 0.19 12.0 6.7 53 4.6 0.3 4.6 5 1 0 5 5 5 0 Leucine rich repeat Pex19 PF04614.7 ESS71127.1 - 4.8e-11 42.7 14.7 2.7e-10 40.3 2.4 3.3 1 1 1 2 2 2 1 Pex19 protein family DUF664 PF04978.7 ESS71127.1 - 0.56 10.4 3.8 0.7 10.1 0.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF664) AAA PF00004.24 ESS71128.1 - 4.3e-16 59.3 0.0 7.7e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 ESS71128.1 - 5.4e-12 45.6 0.0 2.5e-10 40.2 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 ESS71128.1 - 3.1e-11 42.6 0.0 4e-08 32.3 0.0 2.2 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein Rep_fac_C PF08542.6 ESS71128.1 - 8.7e-10 38.4 0.0 3.2e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_22 PF13401.1 ESS71128.1 - 2e-07 31.1 0.0 1.7e-06 28.1 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESS71128.1 - 8.5e-07 28.9 0.0 1.7e-05 24.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 ESS71128.1 - 7.1e-06 25.6 0.0 5.5e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_5 PF07728.9 ESS71128.1 - 9.1e-06 25.4 0.0 6.6e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 ESS71128.1 - 1.1e-05 25.1 0.0 2.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESS71128.1 - 6.1e-05 23.0 0.0 0.0004 20.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.1 ESS71128.1 - 0.00013 21.5 0.2 0.0057 16.2 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_23 PF13476.1 ESS71128.1 - 0.00023 21.5 0.0 0.00033 21.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESS71128.1 - 0.00092 19.0 0.0 0.0028 17.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.8 ESS71128.1 - 0.0012 17.8 0.0 0.0021 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESS71128.1 - 0.0024 16.9 0.0 0.0041 16.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus NB-ARC PF00931.17 ESS71128.1 - 0.0039 16.0 0.0 1.1 8.1 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.1 ESS71128.1 - 0.0051 16.4 0.3 0.011 15.3 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ESS71128.1 - 0.0059 16.1 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 ESS71128.1 - 0.0063 17.3 0.0 0.015 16.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ESS71128.1 - 0.0068 15.8 0.1 0.4 10.0 0.0 2.3 1 1 1 2 2 2 1 AAA-like domain AAA_3 PF07726.6 ESS71128.1 - 0.0095 15.5 0.0 0.029 13.9 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 ESS71128.1 - 0.013 14.6 0.0 0.077 12.1 0.0 2.1 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI DEAD PF00270.24 ESS71128.1 - 0.015 14.7 0.2 0.11 12.0 0.0 2.1 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_2 PF07724.9 ESS71128.1 - 0.024 14.5 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.1 ESS71128.1 - 0.033 14.1 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 ESS71128.1 - 0.042 12.6 0.0 5.8 5.5 0.0 2.4 1 1 1 2 2 2 0 ArgK protein AAA_25 PF13481.1 ESS71128.1 - 0.042 13.2 0.1 0.11 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.1 ESS71128.1 - 0.087 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESS71128.1 - 0.089 12.4 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2075 PF09848.4 ESS71128.1 - 0.092 11.6 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 ESS71128.1 - 0.095 12.5 0.0 0.65 9.7 0.0 1.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.1 ESS71128.1 - 0.1 12.6 0.2 0.91 9.5 0.0 2.4 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_18 PF13238.1 ESS71128.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2968 PF11180.3 ESS71129.1 - 0.019 14.3 1.9 0.029 13.7 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) HAUS6_N PF14661.1 ESS71129.1 - 0.047 13.0 2.8 0.051 12.9 1.9 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus alpha-hel2 PF14456.1 ESS71129.1 - 0.13 10.9 1.4 0.16 10.7 1.0 1.1 1 0 0 1 1 1 0 Alpha-helical domain 2 Med9 PF07544.8 ESS71129.1 - 0.26 11.0 2.6 0.26 11.0 0.2 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF948 PF06103.6 ESS71130.1 - 2.2 8.2 7.6 4.7 7.1 0.3 4.2 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Cys_Met_Meta_PP PF01053.15 ESS71131.1 - 8.1e-129 429.2 0.1 9.2e-129 429.0 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ESS71131.1 - 4.4e-10 39.1 0.4 7.6e-10 38.3 0.3 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 ESS71131.1 - 1.3e-08 34.1 0.1 1.8e-08 33.7 0.1 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 ESS71131.1 - 9.8e-08 31.1 0.1 1.6e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESS71131.1 - 2.4e-06 26.9 0.1 4.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase EF-hand_7 PF13499.1 ESS71132.1 - 4.7e-10 39.4 3.3 5.6e-08 32.8 0.7 3.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESS71132.1 - 3.4e-06 25.9 6.5 0.01 15.0 0.0 4.6 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 ESS71132.1 - 0.00014 21.4 4.9 0.034 14.0 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.1 ESS71132.1 - 0.00016 21.2 4.3 0.04 13.5 0.1 3.9 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 ESS71132.1 - 0.0038 16.4 0.0 0.0038 16.4 0.0 2.7 4 0 0 4 4 4 1 EF hand RRM_1 PF00076.17 ESS71133.1 - 0.00016 21.2 0.1 0.00042 19.9 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESS71133.1 - 0.00084 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAM2 PF07145.10 ESS71133.1 - 0.0019 17.5 0.1 0.0058 16.0 0.1 1.9 1 0 0 1 1 1 1 Ataxin-2 C-terminal region RRM_6 PF14259.1 ESS71133.1 - 0.038 13.9 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF601 PF04642.7 ESS71133.1 - 1.2 8.3 7.5 2 7.6 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 His_Phos_1 PF00300.17 ESS71134.1 - 9.9e-13 48.4 0.0 2.7e-12 47.0 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Vpu PF00558.14 ESS71135.1 - 3.1 7.4 8.4 12 5.4 1.6 2.6 2 0 0 2 2 2 0 Vpu protein Pkinase PF00069.20 ESS71136.1 - 1.3e-52 178.5 0.0 1.2e-51 175.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS71136.1 - 1e-33 116.5 0.0 5.4e-32 110.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESS71136.1 - 5.2e-05 22.3 0.0 0.0037 16.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 ESS71136.1 - 0.014 15.1 0.3 0.18 11.5 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESS71136.1 - 0.11 11.8 0.0 0.26 10.6 0.0 1.6 1 1 1 2 2 2 0 RIO1 family EF-hand_6 PF13405.1 ESS71137.1 - 7.9e-05 22.2 0.3 0.011 15.5 0.0 3.5 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.27 ESS71137.1 - 0.00021 20.3 0.0 0.0061 15.7 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 ESS71137.1 - 0.0064 16.5 2.0 0.061 13.4 0.1 3.0 4 1 0 4 4 4 1 EF-hand domain pair EF-hand_8 PF13833.1 ESS71137.1 - 0.01 15.4 0.2 0.28 10.8 0.0 3.0 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_5 PF13202.1 ESS71137.1 - 0.012 14.9 0.2 0.034 13.5 0.0 1.9 2 0 0 2 2 2 0 EF hand IPK PF03770.11 ESS71139.1 - 3.5e-20 72.4 0.0 4.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase WD40 PF00400.27 ESS71140.1 - 0.00058 19.6 14.4 0.014 15.2 0.1 7.0 8 0 0 8 8 8 1 WD domain, G-beta repeat EF-hand_8 PF13833.1 ESS71140.1 - 0.012 15.2 0.3 0.042 13.4 0.2 2.0 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.1 ESS71140.1 - 0.018 15.1 0.0 0.057 13.5 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair SPRY PF00622.23 ESS71140.1 - 0.039 14.0 0.0 0.65 10.0 0.0 2.7 1 1 1 2 2 2 0 SPRY domain EF-hand_1 PF00036.27 ESS71140.1 - 0.048 12.9 0.1 0.15 11.4 0.1 1.9 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 ESS71140.1 - 0.072 13.0 0.1 0.3 11.0 0.1 2.1 1 0 0 1 1 1 0 EF-hand domain MFS_1 PF07690.11 ESS71142.1 - 3.6e-22 78.5 17.0 4.4e-22 78.2 11.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESS71142.1 - 0.00032 19.4 10.9 0.00039 19.1 7.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter PMT PF02366.13 ESS71142.1 - 0.54 9.5 10.2 0.49 9.6 4.5 2.4 1 1 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase MFS_1 PF07690.11 ESS71143.1 - 9.5e-12 44.2 20.9 1.2e-11 43.8 14.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_Mycoplasma PF07672.8 ESS71143.1 - 0.34 10.0 8.8 0.46 9.6 6.1 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter CoA_binding_3 PF13727.1 ESS71143.1 - 0.54 10.0 7.8 5.6 6.7 2.2 2.3 1 1 1 2 2 2 0 CoA-binding domain WHH PF14414.1 ESS71144.1 - 0.65 9.2 4.4 0.27 10.4 0.5 2.2 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH DEAD PF00270.24 ESS71145.1 - 4.4e-33 114.1 0.0 2.1e-32 111.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESS71145.1 - 2.7e-26 91.2 0.0 6.2e-26 90.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 ESS71145.1 - 0.034 12.5 0.5 0.11 10.8 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1253) Helicase_C_2 PF13307.1 ESS71145.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_22 PF13401.1 ESS71145.1 - 0.21 11.7 2.1 4.5 7.4 0.2 3.5 2 1 1 3 3 3 0 AAA domain DnaJ PF00226.26 ESS71146.1 - 9.4e-15 54.1 0.1 1.9e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain FGGY_N PF00370.16 ESS71147.1 - 4.3e-62 209.6 0.0 6.1e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 ESS71147.1 - 1.5e-56 191.1 0.4 2.4e-56 190.4 0.3 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain MogR_DNAbind PF12181.3 ESS71147.1 - 0.015 15.0 0.0 0.098 12.4 0.0 2.0 2 0 0 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) CrtC PF07143.6 ESS71148.1 - 1e-09 38.1 0.0 2.5e-06 27.0 0.0 3.3 2 1 1 3 3 3 2 Hydroxyneurosporene synthase (CrtC) ThiF PF00899.16 ESS71149.1 - 1.8e-13 50.4 0.0 3.8e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.14 ESS71149.1 - 0.0027 16.8 0.1 0.0043 16.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 ESS71149.1 - 0.0075 16.6 1.7 0.41 11.0 0.2 3.5 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESS71149.1 - 0.013 15.3 0.1 0.029 14.2 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 ESS71149.1 - 0.017 15.3 0.1 0.048 13.9 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.12 ESS71149.1 - 0.035 13.1 0.1 0.055 12.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Shikimate_DH PF01488.15 ESS71149.1 - 0.037 14.1 0.3 0.12 12.5 0.1 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 ESS71149.1 - 0.068 13.1 0.9 0.18 11.7 0.0 2.1 2 1 1 3 3 3 0 TrkA-N domain 2-Hacid_dh_C PF02826.14 ESS71149.1 - 0.086 11.9 0.1 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 ESS71149.1 - 0.12 11.9 0.6 0.36 10.4 0.4 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 ESS71150.1 - 8.5e-33 113.0 0.2 1.8e-32 112.0 0.1 1.5 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 ESS71150.1 - 1e-30 105.0 0.6 1.2e-25 88.8 0.1 2.4 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ESS71150.1 - 1.3e-15 56.4 0.0 2.5e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site zf-CCHC_2 PF13696.1 ESS71151.1 - 1.3e-06 27.7 6.3 1.3e-06 27.7 4.4 2.2 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 ESS71151.1 - 0.037 13.9 4.0 0.037 13.9 2.8 2.4 3 0 0 3 3 3 0 Zinc knuckle Zn-ribbon_8 PF09723.5 ESS71151.1 - 0.22 11.4 3.4 4 7.4 0.2 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-CCHC_4 PF14392.1 ESS71151.1 - 0.28 10.8 2.5 0.56 9.9 1.7 1.5 1 0 0 1 1 1 0 Zinc knuckle NDUFA12 PF05071.11 ESS71152.1 - 1.8e-05 25.1 1.0 4.4e-05 23.8 0.2 2.0 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 ICMT PF04140.9 ESS71153.1 - 1.7e-20 73.0 2.5 4.1e-20 71.7 1.7 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ESS71153.1 - 4.6e-08 33.1 4.1 4.6e-08 33.1 2.8 3.7 2 1 2 4 4 4 1 Phospholipid methyltransferase DUF1295 PF06966.7 ESS71153.1 - 0.008 15.4 0.4 0.015 14.6 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PAF-AH_p_II PF03403.8 ESS71154.1 - 1.9e-13 49.4 0.0 1.7e-12 46.3 0.0 1.9 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 ESS71154.1 - 0.00099 18.8 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESS71154.1 - 0.0052 16.6 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_6 PF12697.2 ESS71154.1 - 0.01 15.7 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PAF-AH_p_II PF03403.8 ESS71155.1 - 4.6e-26 91.0 0.0 1.3e-25 89.4 0.0 1.6 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 ESS71155.1 - 3.9e-12 46.1 0.0 6.2e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESS71155.1 - 8.1e-07 29.1 0.1 2e-06 27.8 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 ESS71155.1 - 1.1e-05 24.4 0.0 5.1e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Lipase_3 PF01764.20 ESS71155.1 - 0.00038 20.0 0.0 0.0008 19.0 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase PF07224.6 ESS71155.1 - 0.006 15.4 0.0 0.23 10.1 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase DUF2974 PF11187.3 ESS71155.1 - 0.0099 15.2 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_3 PF07859.8 ESS71155.1 - 0.027 14.0 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.15 ESS71155.1 - 0.066 12.6 0.0 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 Putative esterase Abhydrolase_1 PF00561.15 ESS71155.1 - 0.084 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.15 ESS71155.1 - 0.096 12.8 0.0 0.24 11.5 0.0 1.6 2 0 0 2 2 2 0 Thioesterase domain Peptidase_S9 PF00326.16 ESS71155.1 - 0.12 11.6 0.0 1.5 8.0 0.0 2.5 3 0 0 3 3 3 0 Prolyl oligopeptidase family DUF1528 PF07515.6 ESS71156.1 - 0.14 12.2 0.0 0.48 10.4 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1528) DNA_pol_A_exo1 PF01612.15 ESS71157.1 - 4.3e-14 52.3 0.0 6.5e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease zf-CCHC PF00098.18 ESS71157.1 - 5.2e-05 22.9 36.9 0.0014 18.4 0.8 4.3 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_6 PF15288.1 ESS71157.1 - 0.15 11.7 25.0 0.22 11.2 1.1 3.5 1 1 2 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.1 ESS71157.1 - 6.7 6.4 28.6 0.49 10.0 1.2 3.8 4 0 0 4 4 4 0 Zinc knuckle CTDII PF01556.13 ESS71158.1 - 1.7e-27 95.1 0.1 3e-20 71.8 0.0 2.3 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESS71158.1 - 8.1e-15 54.6 18.0 8.1e-15 54.6 12.5 1.8 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.14 ESS71158.1 - 0.0037 16.9 7.4 0.027 14.1 0.5 2.4 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family Cytochrom_c3_2 PF14537.1 ESS71158.1 - 0.076 13.3 10.2 0.19 12.1 7.1 1.6 1 0 0 1 1 1 0 Cytochrome c3 Antiterm PF03589.8 ESS71158.1 - 1 9.5 5.7 18 5.4 0.1 2.7 1 1 1 2 2 2 0 Antitermination protein zf-RING_3 PF14369.1 ESS71158.1 - 7.5 6.6 12.7 21 5.2 0.2 4.1 3 1 1 4 4 4 0 zinc-finger Lar_restr_allev PF14354.1 ESS71158.1 - 7.8 6.8 12.6 14 6.0 5.3 3.2 1 1 1 2 2 2 0 Restriction alleviation protein Lar Zeta_toxin PF06414.7 ESS71159.1 - 0.00061 18.9 0.0 0.7 8.9 0.0 2.2 2 0 0 2 2 2 2 Zeta toxin AAA_17 PF13207.1 ESS71159.1 - 0.033 15.0 0.0 0.1 13.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 ESS71159.1 - 0.13 11.4 0.1 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TPR_2 PF07719.12 ESS71160.1 - 4.8e-05 22.9 0.1 0.53 10.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESS71160.1 - 0.0005 20.4 1.0 0.057 14.0 0.2 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESS71160.1 - 0.0013 18.2 0.2 0.099 12.3 0.1 2.9 2 1 1 3 3 3 1 TPR repeat TPR_1 PF00515.23 ESS71160.1 - 0.0037 16.8 0.3 0.74 9.5 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESS71160.1 - 0.019 15.6 0.2 0.063 13.9 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESS71160.1 - 0.051 13.9 0.4 0.16 12.2 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_5 PF12688.2 ESS71160.1 - 0.12 12.4 0.2 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Tetratrico peptide repeat TPR_12 PF13424.1 ESS71160.1 - 0.13 12.1 0.4 4.1 7.4 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat DENN PF02141.16 ESS71161.1 - 8.5e-24 84.2 1.0 1.3e-23 83.6 0.7 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain SPA PF08616.5 ESS71161.1 - 6.1e-05 22.7 0.1 0.00013 21.6 0.1 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis uDENN PF03456.13 ESS71161.1 - 0.00041 20.2 0.0 0.0012 18.7 0.0 1.9 1 0 0 1 1 1 1 uDENN domain PPR PF01535.15 ESS71162.1 - 4.1e-33 111.0 29.5 0.0013 18.5 0.1 15.8 16 0 0 16 16 16 8 PPR repeat PPR_2 PF13041.1 ESS71162.1 - 3e-28 97.5 22.5 6.8e-06 25.9 0.0 12.7 7 4 7 14 14 14 8 PPR repeat family PPR_3 PF13812.1 ESS71162.1 - 2.4e-25 86.6 15.7 0.015 15.5 0.0 14.7 13 1 1 14 14 14 4 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESS71162.1 - 8.1e-10 38.0 0.0 0.062 12.7 0.0 7.3 7 0 0 7 7 7 2 PPR repeat TPR_19 PF14559.1 ESS71162.1 - 1.6e-06 28.3 5.3 0.00022 21.4 0.7 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat AAA_3 PF07726.6 ESS71162.1 - 0.0046 16.5 0.0 0.22 11.1 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Clathrin PF00637.15 ESS71162.1 - 0.0069 15.9 20.4 2.9 7.4 0.0 6.6 6 1 0 7 7 7 2 Region in Clathrin and VPS RhoGAP PF00620.22 ESS71162.1 - 0.036 13.6 2.4 8.2 6.0 0.0 3.8 3 0 0 3 3 3 0 RhoGAP domain TPR_10 PF13374.1 ESS71162.1 - 0.05 13.5 2.0 1.6 8.7 0.1 4.5 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESS71162.1 - 0.05 13.4 0.5 8.3 6.4 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESS71162.1 - 0.2 11.5 4.3 9.2 6.2 0.1 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESS71162.1 - 0.35 11.4 2.5 2.2 8.9 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESS71162.1 - 1.2 9.7 5.0 0.97 10.0 0.2 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat LCM PF04072.9 ESS71163.1 - 2e-26 92.6 0.0 3.8e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_5 PF13854.1 ESS71163.1 - 2.5e-09 36.8 5.5 2.2e-05 24.3 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.1 ESS71163.1 - 4e-07 29.6 5.7 0.013 15.2 0.0 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESS71163.1 - 8.5e-07 28.9 9.0 0.053 13.7 0.1 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESS71163.1 - 0.004 17.2 0.3 6.2 7.1 0.0 4.6 5 0 0 5 5 5 1 Kelch motif MTS PF05175.9 ESS71163.1 - 0.063 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PNPase_C PF12111.3 ESS71163.1 - 0.94 8.7 3.5 20 4.4 0.1 2.7 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal DUF972 PF06156.8 ESS71165.1 - 6.2 7.2 20.2 4.9 7.5 0.8 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF972) PARG_cat PF05028.9 ESS71166.1 - 2.1e-115 385.5 0.0 2.7e-115 385.2 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) NfeD PF01957.13 ESS71166.1 - 0.086 12.9 0.1 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding Pkinase PF00069.20 ESS71169.1 - 2.3e-40 138.4 0.0 5.5e-40 137.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESS71169.1 - 2.8e-22 79.0 0.4 1.3e-17 63.7 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 ESS71169.1 - 0.0029 16.6 0.0 0.0098 14.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESS71169.1 - 0.055 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 RIO1 family PX PF00787.19 ESS71169.1 - 0.1 12.3 0.3 0.33 10.7 0.2 1.8 1 0 0 1 1 1 0 PX domain Leo1 PF04004.8 ESS71170.1 - 1e-27 96.8 0.1 1e-27 96.8 0.1 2.0 2 0 0 2 2 2 1 Leo1-like protein Aminotran_5 PF00266.14 ESS71171.1 - 3.1e-53 180.8 0.0 4e-53 180.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESS71171.1 - 0.0025 17.0 0.0 0.0035 16.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Prok-RING_1 PF14446.1 ESS71172.1 - 0.049 13.3 0.9 0.099 12.3 0.6 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 MFS_1 PF07690.11 ESS71173.1 - 4.3e-24 84.8 37.3 1.6e-20 73.1 7.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESS71173.1 - 3e-07 29.3 2.7 3e-07 29.3 1.9 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.11 ESS71174.1 - 1.5e-27 96.2 19.5 1.5e-27 96.2 13.5 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESS71174.1 - 1e-07 30.9 5.5 1e-07 30.9 3.8 2.6 2 2 0 2 2 2 1 Sugar (and other) transporter DUF962 PF06127.6 ESS71174.1 - 9.8 6.1 8.5 1.7 8.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF962) Abhydrolase_6 PF12697.2 ESS71175.1 - 2.2e-06 27.7 2.3 7.8e-06 25.9 0.2 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESS71175.1 - 4.4e-06 26.5 0.6 9.3e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.7 ESS71175.1 - 5.4e-05 22.1 0.0 7.2e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_1 PF00561.15 ESS71175.1 - 0.00014 21.4 0.4 0.00074 19.1 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 ESS71175.1 - 0.00083 18.9 0.4 0.0024 17.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESS71175.1 - 0.0016 17.6 0.0 0.0029 16.8 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2305 PF10230.4 ESS71175.1 - 0.054 12.9 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Lipase_3 PF01764.20 ESS71175.1 - 0.1 12.1 1.0 0.58 9.7 0.0 2.5 3 0 0 3 3 3 0 Lipase (class 3) UPF0227 PF05728.7 ESS71175.1 - 0.16 11.6 0.0 1.9 8.2 0.0 2.3 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0227) IQ PF00612.22 ESS71176.1 - 0.0037 16.7 1.6 0.015 14.8 1.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif MMR_HSR1 PF01926.18 ESS71178.1 - 2.6e-08 33.8 0.0 4.9e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESS71178.1 - 0.00022 20.5 0.0 0.00063 19.0 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B DNA_pol_A_exo1 PF01612.15 ESS71178.1 - 0.12 11.8 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 3'-5' exonuclease GTP_EFTU PF00009.22 ESS71178.1 - 0.14 11.5 0.0 1.9 7.9 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Prp19 PF08606.6 ESS71179.1 - 0.0092 15.6 0.6 0.0092 15.6 0.4 2.5 2 1 1 3 3 3 1 Prp19/Pso4-like Reo_sigmaC PF04582.7 ESS71179.1 - 0.13 11.4 3.4 0.27 10.3 0.1 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein GalKase_gal_bdg PF10509.4 ESS71180.1 - 9.4e-19 66.4 0.5 2.6e-18 65.0 0.1 2.0 2 0 0 2 2 2 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 ESS71180.1 - 3.7e-09 36.6 0.0 1.1e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESS71180.1 - 0.00041 20.3 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain MFS_1 PF07690.11 ESS71181.1 - 3.3e-08 32.6 46.0 3.3e-08 32.6 31.9 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MadM PF03818.8 ESS71181.1 - 1.3 8.5 10.6 1.3 8.6 1.9 3.0 2 0 0 2 2 2 0 Malonate/sodium symporter MadM subunit Acyl-CoA_dh_1 PF00441.19 ESS71182.1 - 3.2e-40 137.6 3.6 4.3e-40 137.2 2.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESS71182.1 - 1.1e-24 87.1 0.0 3.6e-24 85.5 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESS71182.1 - 3.4e-21 74.4 0.1 6e-21 73.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESS71182.1 - 2.4e-19 69.9 0.8 3.4e-19 69.4 0.1 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain SNARE PF05739.14 ESS71183.1 - 1.1e-18 66.6 1.0 1.1e-18 66.6 0.7 2.8 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESS71183.1 - 0.0028 17.7 9.4 0.0098 16.0 2.0 2.4 2 1 0 2 2 2 1 Syntaxin N-SET PF11764.3 ESS71183.1 - 0.048 13.5 0.6 0.16 11.8 0.4 1.8 1 1 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component N Syntaxin_2 PF14523.1 ESS71183.1 - 0.12 12.4 2.7 1.1 9.3 0.2 2.6 2 1 0 2 2 2 0 Syntaxin-like protein Prominin PF05478.6 ESS71183.1 - 0.14 9.6 5.2 0.084 10.4 1.2 1.9 1 1 1 2 2 2 0 Prominin FERM_M PF00373.13 ESS71183.1 - 0.21 11.7 1.4 4.5 7.4 0.1 2.3 2 0 0 2 2 2 0 FERM central domain MCPsignal PF00015.16 ESS71183.1 - 0.33 10.4 7.1 0.3 10.5 1.6 2.5 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Epsilon_antitox PF08998.6 ESS71183.1 - 0.54 10.2 3.2 0.42 10.6 0.5 2.0 2 0 0 2 2 2 0 Bacterial epsilon antitoxin DUF2408 PF10303.4 ESS71183.1 - 0.86 9.7 6.0 1.8 8.7 3.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) TRAPPC9-Trs120 PF08626.6 ESS71185.1 - 4.1e-09 34.4 0.0 0.0035 14.7 0.0 4.4 3 1 1 4 4 4 4 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit BTB_2 PF02214.17 ESS71186.1 - 1.9e-09 37.6 0.1 5.9e-09 36.0 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain AAA_33 PF13671.1 ESS71190.1 - 0.046 13.5 0.0 0.076 12.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain zf-HC5HC2H PF13771.1 ESS71191.1 - 8.7e-05 22.5 10.7 8.7e-05 22.5 7.4 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESS71191.1 - 0.006 16.5 8.1 0.006 16.5 5.6 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain NIF PF03031.13 ESS71192.1 - 1.6e-30 105.8 0.2 2.6e-30 105.2 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase zf-DHHC PF01529.15 ESS71193.1 - 6.1e-30 103.8 1.3 1.2e-29 102.9 0.1 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4013 PF13197.1 ESS71193.1 - 0.00068 19.0 2.0 0.00068 19.0 1.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4013) Claudin_2 PF13903.1 ESS71193.1 - 0.025 14.2 3.7 1.9 8.1 0.6 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4117 PF13491.1 ESS71193.1 - 0.66 9.4 8.6 0.057 12.8 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4117) DUF4149 PF13664.1 ESS71193.1 - 4.9 7.2 10.0 2.2 8.4 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) Peptidase_M8 PF01457.11 ESS71195.1 - 4.8e-134 447.5 0.0 5.9e-134 447.2 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_3 PF13582.1 ESS71195.1 - 0.066 13.7 0.3 0.24 11.9 0.1 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 ESS71195.1 - 0.093 12.6 0.1 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.3 ESS71195.1 - 0.099 11.9 0.3 0.17 11.2 0.0 1.5 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase SprT-like PF10263.4 ESS71195.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 SprT-like family RVT_1 PF00078.22 ESS71196.1 - 4.8e-16 58.7 0.0 9.2e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EBP50_C-term PF09007.6 ESS71196.1 - 0.26 11.1 0.1 0.26 11.1 0.1 2.3 3 0 0 3 3 3 0 EBP50, C-terminal zf-C2H2 PF00096.21 ESS71196.1 - 1.9 9.0 8.9 0.65 10.4 1.0 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type HSBP1 PF06825.7 ESS71198.1 - 3.1e-27 93.9 6.1 3.9e-27 93.5 4.2 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 DUF2130 PF09903.4 ESS71198.1 - 0.0038 16.0 0.2 0.0042 15.8 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2130) FliD_C PF07195.7 ESS71198.1 - 0.016 14.5 0.1 0.018 14.3 0.1 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF241 PF03087.9 ESS71198.1 - 0.017 14.6 0.1 0.021 14.2 0.1 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function FtsK_SpoIIIE PF01580.13 ESS71198.1 - 0.021 14.3 0.1 0.025 14.0 0.1 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Laminin_I PF06008.9 ESS71198.1 - 0.023 13.9 1.1 0.029 13.6 0.7 1.1 1 0 0 1 1 1 0 Laminin Domain I AAA_27 PF13514.1 ESS71198.1 - 0.025 12.2 0.0 0.026 12.2 0.0 1.0 1 0 0 1 1 1 0 AAA domain SF-assemblin PF06705.6 ESS71198.1 - 0.027 13.6 0.1 0.031 13.4 0.1 1.1 1 0 0 1 1 1 0 SF-assemblin/beta giardin Helicase_IV_N PF12462.3 ESS71198.1 - 0.031 13.9 0.1 0.039 13.5 0.0 1.1 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Hormone_1 PF00103.15 ESS71198.1 - 0.042 13.1 0.2 0.046 13.0 0.2 1.1 1 0 0 1 1 1 0 Somatotropin hormone family DUF2365 PF10157.4 ESS71198.1 - 0.043 13.7 0.1 0.12 12.2 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) BLOC1_2 PF10046.4 ESS71198.1 - 0.053 13.6 0.4 0.12 12.4 0.3 1.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2884 PF11101.3 ESS71198.1 - 0.055 12.8 0.9 0.07 12.5 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) DHC_N1 PF08385.7 ESS71198.1 - 0.062 11.6 0.4 0.067 11.5 0.3 1.0 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 UPF0449 PF15136.1 ESS71198.1 - 0.072 13.2 0.1 0.095 12.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Baculo_PEP_C PF04513.7 ESS71198.1 - 0.099 12.4 0.1 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Osmo_CC PF08946.5 ESS71198.1 - 0.11 12.5 0.2 0.17 11.9 0.2 1.3 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Pro_isomerase PF00160.16 ESS71199.1 - 1.3e-33 116.4 0.0 1.4e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin PF00085.15 ESS71200.1 - 4.5e-11 42.3 0.0 7e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin DUF599 PF04654.7 ESS71200.1 - 0.063 12.4 0.1 0.08 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF599 DUF3653 PF12375.3 ESS71200.1 - 0.63 10.2 2.6 1.2 9.4 1.8 1.5 1 0 0 1 1 1 0 Phage protein Flavokinase PF01687.12 ESS71201.1 - 3e-28 98.1 0.0 3.6e-28 97.9 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase KH_1 PF00013.24 ESS71202.1 - 7.6e-06 25.4 0.2 5e-05 22.8 0.1 2.1 2 0 0 2 2 2 1 KH domain Rep_fac-A_3 PF08661.6 ESS71203.1 - 7.4e-09 35.4 0.0 8.7e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 NifU_N PF01592.11 ESS71204.1 - 1.2e-45 154.5 0.0 1.6e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain RelB PF04221.7 ESS71204.1 - 0.0085 15.8 0.1 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 RelB antitoxin CO_deh_flav_C PF03450.12 ESS71204.1 - 0.01 15.7 0.0 0.03 14.2 0.0 1.7 1 1 1 2 2 2 0 CO dehydrogenase flavoprotein C-terminal domain NDUF_B7 PF05676.8 ESS71206.1 - 8.9e-06 25.0 0.3 1.4e-05 24.4 0.2 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Ribosomal_L16 PF00252.13 ESS71207.1 - 0.19 11.4 2.3 0.16 11.6 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein L16p/L10e Ank_2 PF12796.2 ESS71208.1 - 1.2e-30 105.6 2.4 4.3e-15 55.8 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESS71208.1 - 1.1e-26 91.2 1.3 3e-11 42.5 0.0 5.2 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.1 ESS71208.1 - 2.3e-25 88.4 0.6 1.8e-09 37.8 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESS71208.1 - 7.8e-20 68.9 0.5 1.7e-06 27.6 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 ESS71208.1 - 1.3e-19 69.7 3.8 1.9e-10 40.6 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Tctex-1 PF03645.8 ESS71209.1 - 2.4e-26 91.5 0.0 2.8e-26 91.3 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family DSPc PF00782.15 ESS71209.1 - 0.064 12.8 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Glyoxalase PF00903.20 ESS71211.1 - 9.6e-16 57.9 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 ESS71211.1 - 2.8e-15 56.8 0.0 3.3e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 ESS71211.1 - 5e-10 39.3 0.0 7.4e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.1 ESS71211.1 - 0.0024 17.5 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 CppA N-terminal Glyoxalase_3 PF13468.1 ESS71211.1 - 0.13 12.1 0.0 16 5.3 0.0 2.4 1 1 2 3 3 3 0 Glyoxalase-like domain Rhabdo_M2 PF04785.7 ESS71212.1 - 0.017 14.1 0.3 0.053 12.5 0.1 2.0 1 1 1 2 2 2 0 Rhabdovirus matrix protein M2 Ribosomal_L31e PF01198.14 ESS71213.1 - 1.9e-28 97.9 1.1 1.9e-28 97.9 0.7 1.6 2 0 0 2 2 2 1 Ribosomal protein L31e Dynein_light PF01221.13 ESS71214.1 - 2.2e-18 66.0 0.3 4.3e-16 58.6 0.1 2.1 1 1 0 2 2 2 2 Dynein light chain type 1 Ground-like PF04155.13 ESS71214.1 - 5.7e-09 36.1 0.0 1.2e-08 35.1 0.0 1.6 1 1 0 1 1 1 1 Ground-like domain Dak2 PF02734.12 ESS71214.1 - 0.073 12.7 0.0 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 DAK2 domain Sybindin PF04099.7 ESS71215.1 - 3e-13 49.6 0.1 3.6e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Mpv17_PMP22 PF04117.7 ESS71215.1 - 0.19 11.3 1.3 0.36 10.4 0.9 1.5 1 0 0 1 1 1 0 Mpv17 / PMP22 family