# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Ribosomal_L18 PF17135.4 KPI82395.1 - 1.8e-46 157.9 0.9 2e-46 157.8 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 KPI82395.1 - 0.02 15.6 0.0 0.02 15.6 0.0 1.6 2 0 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A EF-hand_1 PF00036.32 KPI82396.1 - 3e-43 142.2 12.0 1.5e-10 39.9 1.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KPI82396.1 - 1.6e-36 124.6 3.7 6.9e-19 68.1 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KPI82396.1 - 5e-32 109.5 11.3 1.3e-14 53.7 0.7 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KPI82396.1 - 2.1e-31 105.1 6.6 1.3e-09 37.2 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KPI82396.1 - 3.2e-28 95.9 9.4 5.8e-07 28.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KPI82396.1 - 6.6e-16 58.4 0.2 6.8e-09 35.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KPI82396.1 - 1.3e-09 37.9 0.8 5.4e-05 23.1 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KPI82396.1 - 6.6e-08 32.9 0.0 0.0014 18.9 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KPI82396.1 - 2.6e-06 28.2 0.0 0.00063 20.6 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KPI82396.1 - 1.9e-05 24.6 1.0 0.035 14.1 0.0 3.3 3 1 1 4 4 4 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 KPI82396.1 - 0.00016 21.7 1.1 0.00074 19.6 0.1 2.3 2 2 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 KPI82396.1 - 0.00017 21.7 2.8 0.017 15.3 0.4 3.1 1 1 2 3 3 3 1 Dockerin type I domain TerB PF05099.13 KPI82396.1 - 0.00041 20.3 0.3 0.23 11.4 0.0 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB DUF3349 PF11829.8 KPI82396.1 - 0.00091 20.0 0.3 3.2 8.6 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 KPI82396.1 - 0.0013 18.6 0.8 0.21 11.5 0.3 3.3 1 1 1 2 2 2 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 KPI82396.1 - 0.0018 18.6 0.3 1.6 9.1 0.1 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb4 DUF4497 PF14924.6 KPI82396.1 - 0.0024 18.3 0.0 0.92 10.0 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) Poly_export PF02563.16 KPI82396.1 - 0.0042 17.3 0.2 0.9 9.8 0.0 3.1 1 1 0 2 2 2 1 Polysaccharide biosynthesis/export protein MotA_activ PF09114.10 KPI82396.1 - 0.0059 16.7 0.0 0.12 12.5 0.0 2.2 2 0 0 2 2 2 1 Transcription factor MotA, activation domain DUF1103 PF06513.11 KPI82396.1 - 0.0061 16.2 1.1 0.0071 16.0 1.1 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) SurA_N_2 PF13623.6 KPI82396.1 - 0.015 15.2 1.4 0.56 10.1 0.2 2.2 1 1 1 2 2 2 0 SurA N-terminal domain DUF5580 PF17743.1 KPI82396.1 - 0.019 13.6 0.0 0.019 13.5 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_14 PF17959.1 KPI82396.1 - 0.033 14.5 0.2 5.6 7.4 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain dCache_2 PF08269.11 KPI82396.1 - 0.04 13.1 0.1 2.7 7.1 0.0 2.2 1 1 0 2 2 2 0 Cache domain Fe_hyd_lg_C PF02906.14 KPI82396.1 - 0.045 13.4 0.2 0.11 12.1 0.2 1.7 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain RloB PF13707.6 KPI82396.1 - 0.081 13.1 0.9 1.1 9.4 0.1 2.1 1 1 1 2 2 2 0 RloB-like protein Ribosomal_S9 PF00380.19 KPI82397.1 - 2.8e-19 69.8 0.2 3e-19 69.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_S19 PF00203.21 KPI82398.1 - 1.5e-29 101.7 0.3 2.1e-29 101.2 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 PmbA_TldD PF01523.16 KPI82398.1 - 0.04 13.8 0.0 0.044 13.6 0.0 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase SF3a60_bindingd PF12108.8 KPI82398.1 - 0.048 13.6 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain DUF365 PF04033.12 KPI82398.1 - 0.13 12.6 0.2 0.21 11.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF365) Ribosomal_L31e PF01198.19 KPI82401.1 - 9.9e-26 89.8 0.6 9.9e-26 89.8 0.6 1.5 2 0 0 2 2 2 1 Ribosomal protein L31e ATP-synt_C PF00137.21 KPI82403.1 - 1.3e-28 99.1 33.4 3.3e-19 69.0 14.6 2.4 2 0 0 2 2 2 2 ATP synthase subunit C GerA PF03323.13 KPI82403.1 - 0.23 9.9 3.1 2.8 6.3 0.3 2.2 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein TctB PF07331.11 KPI82403.1 - 3.1 8.1 12.8 17 5.7 12.8 2.1 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF4064 PF13273.6 KPI82403.1 - 7.4 6.9 14.8 22 5.4 4.9 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Ribosomal_L2_C PF03947.18 KPI82406.1 - 4.1e-43 146.6 2.1 7.7e-43 145.7 2.1 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KPI82406.1 - 3.6e-06 26.9 0.0 1.2e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Peptidase_M32 PF02074.15 KPI82407.1 - 7.1e-76 255.9 0.0 7.9e-76 255.8 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Ribosomal_L13e PF01294.18 KPI82408.1 - 1.4e-62 210.8 5.4 1.8e-62 210.4 5.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e DUF4169 PF13770.6 KPI82408.1 - 0.38 11.1 0.2 0.38 11.1 0.2 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4169) Ribosomal_L14e PF01929.17 KPI82409.1 - 5.6e-18 65.2 2.7 5.6e-18 65.2 2.7 2.4 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.29 KPI82409.1 - 0.00016 21.5 0.9 0.00026 20.8 0.9 1.3 1 0 0 1 1 1 1 KOW motif Leptin PF02024.15 KPI82409.1 - 0.13 12.1 0.1 12 5.7 0.0 2.2 2 0 0 2 2 2 0 Leptin Ribosomal_L28e PF01778.17 KPI82410.1 - 8.6e-20 71.6 0.5 8.6e-20 71.6 0.5 1.5 2 0 0 2 2 2 1 Ribosomal L28e protein family HSP70 PF00012.20 KPI82411.1 - 8.1e-60 202.6 7.1 1e-59 202.3 7.1 1.1 1 0 0 1 1 1 1 Hsp70 protein ApoO PF09769.9 KPI82411.1 - 0.25 11.3 1.1 0.5 10.3 1.1 1.5 1 0 0 1 1 1 0 Apolipoprotein O Amastin PF07344.11 KPI82414.1 - 8.4e-21 74.4 5.6 9.6e-21 74.2 5.6 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein MARVEL PF01284.23 KPI82414.1 - 0.0055 16.7 2.8 0.0055 16.7 2.8 2.1 1 1 1 2 2 2 1 Membrane-associating domain SUR7 PF06687.12 KPI82414.1 - 0.43 10.2 18.1 0.11 12.1 10.5 2.0 1 1 1 2 2 2 0 SUR7/PalI family NB PF04159.13 KPI82414.1 - 3.2 7.8 9.2 11 6.2 4.8 2.7 1 1 1 2 2 2 0 NB glycoprotein DUF4006 PF13179.6 KPI82414.1 - 8 6.5 9.1 3.5 7.6 0.1 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF4006) Ribosomal_S10 PF00338.22 KPI82415.1 - 7.7e-24 83.8 0.2 8.9e-24 83.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Ribosomal_S2 PF00318.20 KPI82416.1 - 5.5e-28 97.7 0.2 1.3e-16 60.5 0.2 2.0 1 1 1 2 2 2 2 Ribosomal protein S2 Sulfotransfer_1 PF00685.27 KPI82416.1 - 0.034 13.6 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain DUF4530 PF15039.6 KPI82418.1 - 0.17 12.0 0.5 0.24 11.6 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Pkinase PF00069.25 KPI82419.1 - 1.3e-57 195.2 0.0 1.5e-57 195.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82419.1 - 7.8e-42 143.3 0.0 9.4e-42 143.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI82419.1 - 2.4e-07 30.4 0.0 3.1e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KPI82419.1 - 0.0051 15.8 0.1 0.0068 15.4 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KPI82419.1 - 0.065 12.6 0.1 0.12 11.7 0.1 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 KPI82419.1 - 0.074 12.0 0.1 0.1 11.6 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 KPI82419.1 - 0.2 11.6 0.1 4.1 7.3 0.1 2.1 1 1 2 3 3 3 0 Phosphotransferase enzyme family ECSIT_C PF14784.6 KPI82420.1 - 0.05 13.9 1.9 0.068 13.5 1.1 1.8 1 1 0 1 1 1 0 C-terminal domain of the ECSIT protein Sec20 PF03908.13 KPI82420.1 - 0.2 11.6 6.1 0.2 11.6 4.1 2.1 2 0 0 2 2 2 0 Sec20 DUF3584 PF12128.8 KPI82420.1 - 0.69 7.4 34.1 0.27 8.7 31.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.6 KPI82420.1 - 4.7 6.5 36.2 0.5 9.7 17.2 3.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CorA PF01544.18 KPI82420.1 - 6.4 6.0 15.0 6.2 6.0 6.9 2.4 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Ribosomal_S3Ae PF01015.18 KPI82421.1 - 1.3e-67 227.4 4.1 1.5e-67 227.1 4.1 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Pkinase PF00069.25 KPI82422.1 - 3.4e-44 151.2 0.0 6.3e-44 150.3 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82422.1 - 1e-27 97.1 0.2 3.4e-24 85.5 0.1 2.0 1 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI82422.1 - 2.9e-08 33.4 0.1 2.3e-07 30.4 0.1 2.1 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI82422.1 - 0.00022 20.6 0.5 0.0013 18.1 0.5 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI82422.1 - 0.00024 21.1 0.6 0.0065 16.4 0.5 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 KPI82422.1 - 0.0028 17.3 0.4 0.004 16.8 0.4 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KPI82422.1 - 0.0029 16.4 0.0 0.0041 15.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KPI82422.1 - 0.0039 16.2 0.1 0.0061 15.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 KPI82422.1 - 0.1 12.2 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 KPI82422.1 - 0.16 10.9 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ribosomal_L7Ae PF01248.26 KPI82423.1 - 4.7e-20 71.1 0.3 9.1e-20 70.2 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KPI82423.1 - 0.00016 21.8 0.2 0.00028 21.0 0.1 1.4 1 1 0 1 1 1 1 RNase P subunit Pop3 Peripla_BP_6 PF13458.6 KPI82424.1 - 2.5e-06 27.4 0.0 3.2e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Ribosomal_S4e PF00900.20 KPI82425.1 - 6.5e-24 83.6 0.0 1e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 KPI82425.1 - 9.5e-17 60.4 0.0 1.6e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 KPI82425.1 - 5.9e-08 32.7 0.4 1.3e-07 31.6 0.4 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 KPI82425.1 - 1.2e-07 31.3 0.0 2.9e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 KPI82425.1 - 1.9e-05 24.4 1.6 3.1e-05 23.7 0.5 2.0 2 0 0 2 2 2 1 KOW motif ABC2_membrane_3 PF12698.7 KPI82426.1 - 3.5e-24 85.6 13.3 4e-24 85.4 13.3 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 KPI82426.1 - 0.22 10.7 11.1 0.29 10.4 11.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein LapA_dom PF06305.11 KPI82426.1 - 1.3 8.9 4.6 0.68 9.8 0.6 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Peptidase_U4 PF03419.13 KPI82426.1 - 3.2 6.9 11.9 4.1 6.6 11.9 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA LRR_8 PF13855.6 KPI82427.1 - 2.6e-07 30.3 0.0 4.6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KPI82427.1 - 0.00015 22.1 0.0 0.0017 18.7 0.0 2.3 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI82427.1 - 0.0088 16.0 0.6 3.5 7.9 0.1 3.6 4 0 0 4 4 4 1 Leucine Rich repeat DoxD PF04173.13 KPI82427.1 - 0.3 11.0 0.4 18 5.2 0.1 2.3 2 0 0 2 2 2 0 TQO small subunit DoxD MFS_1 PF07690.16 KPI82434.1 - 4.8e-11 42.2 21.0 1.3e-10 40.8 21.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 KPI82434.1 - 0.00019 21.0 18.6 0.0043 16.6 18.6 2.0 1 1 0 1 1 1 1 Nodulin-like DUF3147 PF11345.8 KPI82434.1 - 0.47 10.8 12.5 0.78 10.1 0.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3147) Ribosomal_L5e PF17144.4 KPI82435.1 - 1.1e-38 132.9 0.0 1.9e-38 132.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KPI82435.1 - 2.7e-27 95.5 7.4 4.1e-27 94.9 7.4 1.3 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region VSP PF03302.13 KPI82436.1 - 0.00036 19.5 3.2 0.00041 19.3 3.2 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein cEGF PF12662.7 KPI82436.1 - 5.7 7.0 8.8 0.77 9.7 2.4 2.5 2 1 0 2 2 2 0 Complement Clr-like EGF-like Zip PF02535.22 KPI82437.1 - 3.7e-32 111.9 0.6 3.9e-32 111.8 0.6 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter PLAC8 PF04749.17 KPI82438.1 - 0.00033 21.6 43.3 0.00061 20.7 43.3 1.6 1 1 0 1 1 1 1 PLAC8 family His_Phos_2 PF00328.22 KPI82439.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Calpain_III PF01067.22 KPI82443.1 - 1.2e-08 35.3 0.0 1.8e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III Peptidase_C2 PF00648.21 KPI82443.1 - 0.013 14.6 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease Histone_H2A_C PF16211.5 KPI82444.1 - 6.3e-11 41.8 0.9 1.5e-10 40.6 0.9 1.7 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KPI82444.1 - 5.2e-06 26.8 0.0 7.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KPI82444.1 - 0.02 15.1 0.2 0.035 14.4 0.0 1.6 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mito_carr PF00153.27 KPI82446.1 - 4.2e-67 222.1 3.1 6.4e-24 83.7 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 KPI82446.1 - 0.022 13.9 0.3 0.04 13.1 0.1 1.5 2 0 0 2 2 2 0 Fuseless ACAS_N PF16177.5 KPI82446.1 - 0.04 13.8 0.5 0.12 12.3 0.5 1.8 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus RL10P_insert PF17777.1 KPI82447.1 - 5.9e-21 74.2 0.2 1.1e-20 73.4 0.2 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 KPI82447.1 - 6.4e-15 55.5 9.1 6.4e-15 55.5 9.1 2.6 4 0 0 4 4 4 1 60s Acidic ribosomal protein Ribosomal_L10 PF00466.20 KPI82447.1 - 1.8e-12 47.2 0.1 4.3e-12 46.0 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 DUF4648 PF15505.6 KPI82448.1 - 0.01 16.7 1.8 0.026 15.4 1.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4648) YuzL PF14115.6 KPI82448.1 - 0.04 14.4 1.1 0.088 13.3 1.1 1.5 1 0 0 1 1 1 0 YuzL-like protein NPL PF17800.1 KPI82449.1 - 5.6e-19 68.6 0.1 5.6e-19 68.6 0.1 2.1 2 0 0 2 2 2 1 Nucleoplasmin-like domain SDA1 PF05285.12 KPI82449.1 - 0.0002 20.9 19.6 0.00025 20.6 19.6 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 KPI82449.1 - 0.0045 15.3 19.1 0.0052 15.1 19.1 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 KPI82449.1 - 0.005 15.2 14.0 0.0074 14.6 14.0 1.3 1 0 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 KPI82449.1 - 0.54 9.6 22.5 0.72 9.1 22.5 1.2 1 0 0 1 1 1 0 BUD22 Hydrolase_6 PF13344.6 KPI82451.1 - 4.4e-21 74.9 0.0 6.7e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase FA_hydroxylase PF04116.13 KPI82452.1 - 1.7e-21 77.0 20.3 1.7e-21 77.0 20.3 1.8 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily Peptidase_M8 PF01457.16 KPI82453.1 - 7.1e-78 262.6 2.2 2.2e-57 194.9 2.3 2.0 2 0 0 2 2 2 2 Leishmanolysin HHH PF00633.23 KPI82453.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Pkinase PF00069.25 KPI82454.1 - 8.4e-33 113.8 0.0 1.1e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82454.1 - 5.8e-11 42.2 0.0 8.5e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI82454.1 - 0.0098 15.8 0.9 1 9.2 0.1 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-PolyVal PF18762.1 KPI82454.1 - 0.16 11.9 0.0 0.27 11.2 0.0 1.2 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins FA_desaturase PF00487.24 KPI82456.1 - 2.2e-21 76.8 26.1 3.7e-21 76.1 26.1 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 KPI82456.1 - 1.8e-14 53.0 0.4 3.4e-14 52.0 0.4 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) ABC_membrane PF00664.23 KPI82458.1 - 2.9e-28 99.3 7.4 3.3e-28 99.1 7.4 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region LRR_8 PF13855.6 KPI82459.1 - 5.2e-22 77.4 18.1 4.8e-09 35.9 1.7 4.1 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KPI82459.1 - 8.9e-17 60.9 12.4 0.0032 17.8 0.2 5.3 3 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI82459.1 - 8e-05 22.7 16.2 20 6.2 1.2 7.8 7 1 1 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 KPI82459.1 - 0.04 14.0 20.7 0.84 9.9 0.8 6.5 7 0 0 7 7 7 0 Leucine Rich repeat MGC-24 PF05283.11 KPI82459.1 - 0.11 12.9 18.4 0.18 12.3 18.4 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin LRR_8 PF13855.6 KPI82460.1 - 1.6e-05 24.6 0.1 0.022 14.5 0.0 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI82460.1 - 0.014 15.8 0.2 7.2 7.2 0.0 2.8 1 1 3 4 4 4 0 Leucine Rich repeats (2 copies) EF1G PF00647.19 KPI82461.1 - 2.5e-40 136.8 0.3 6.4e-40 135.5 0.2 1.7 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 KPI82461.1 - 4.4e-12 46.1 0.1 4.4e-12 46.1 0.1 2.5 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KPI82461.1 - 5.2e-06 26.7 0.4 3.9e-05 23.9 0.0 2.6 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KPI82461.1 - 5.1e-05 23.4 0.1 5.1e-05 23.4 0.1 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KPI82461.1 - 0.00027 20.9 0.2 0.00062 19.7 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4187 PF13821.6 KPI82461.1 - 0.046 13.5 2.2 0.11 12.3 2.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) Aminotran_1_2 PF00155.21 KPI82462.1 - 2e-57 195.0 0.0 3.1e-57 194.4 0.0 1.2 1 1 0 1 1 1 1 Aminotransferase class I and II FYVE_2 PF02318.16 KPI82462.1 - 0.13 12.4 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger LRR_8 PF13855.6 KPI82463.1 - 7.1e-30 102.6 56.2 1.7e-08 34.1 3.3 5.2 2 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 KPI82463.1 - 2.5e-21 75.4 25.7 3.9e-05 23.9 0.6 6.5 2 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI82463.1 - 6.1e-09 35.2 14.6 46 5.1 0.0 10.0 9 1 0 9 9 9 0 Leucine Rich Repeat Spo7_2_N PF15407.6 KPI82463.1 - 0.0078 15.8 0.5 1.9 8.2 0.0 4.6 3 2 2 5 5 5 1 Sporulation protein family 7 FERM_M PF00373.18 KPI82463.1 - 0.0083 16.5 0.1 0.23 11.9 0.1 3.2 1 1 0 1 1 1 1 FERM central domain T4SS PF07996.11 KPI82463.1 - 0.024 15.1 8.6 7.6 6.9 2.3 4.3 2 1 3 5 5 5 0 Type IV secretion system proteins LRR_9 PF14580.6 KPI82463.1 - 0.04 13.4 1.4 2.8 7.4 0.1 2.9 1 1 2 3 3 3 0 Leucine-rich repeat PGAP1 PF07819.13 KPI82463.1 - 0.057 13.1 0.2 20 4.8 0.0 3.0 1 1 1 3 3 3 0 PGAP1-like protein DUF237 PF03072.14 KPI82463.1 - 3.6 7.6 4.5 16 5.6 0.0 4.1 2 1 2 5 5 5 0 Domain of unknown function (DUF237) Lipase_3 PF01764.25 KPI82465.1 - 5.8e-26 91.1 0.0 8.4e-26 90.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KPI82465.1 - 0.0056 16.0 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 KPI82465.1 - 0.031 13.8 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 KPI82465.1 - 0.043 14.4 5.1 0.18 12.4 5.2 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Thioesterase PF00975.20 KPI82465.1 - 0.06 13.5 0.2 0.12 12.4 0.1 1.5 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_5 PF12695.7 KPI82465.1 - 0.089 12.5 0.0 0.38 10.5 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Actin PF00022.19 KPI82467.1 - 7.8e-135 449.6 0.0 6.9e-134 446.5 0.0 1.9 1 1 0 1 1 1 1 Actin HTH_13 PF11972.8 KPI82468.1 - 0.12 12.4 0.3 0.24 11.5 0.2 1.6 1 1 1 2 2 2 0 HTH DNA binding domain EF-hand_7 PF13499.6 KPI82469.1 - 2.2e-23 82.5 6.6 5.6e-12 45.9 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI82469.1 - 6.4e-21 72.3 1.8 1.7e-05 24.0 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KPI82469.1 - 1.5e-19 68.2 3.2 0.00019 21.1 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KPI82469.1 - 1e-14 54.1 2.3 0.00069 19.4 0.3 3.4 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KPI82469.1 - 2e-14 52.3 2.6 5.3e-05 22.5 0.1 4.1 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 KPI82469.1 - 3.6e-09 36.9 0.2 9.3e-06 25.9 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KPI82469.1 - 4.7e-05 23.2 0.6 0.83 9.6 0.0 3.5 2 2 2 4 4 4 2 EF hand EF-hand_11 PF08976.11 KPI82469.1 - 0.035 15.0 0.9 5.7 7.9 0.0 2.2 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.13 KPI82469.1 - 0.2 11.6 0.8 9.1 6.2 0.0 3.3 1 1 3 4 4 4 0 Caleosin related protein Ribosomal_L4 PF00573.22 KPI82470.1 - 1.7e-28 99.6 0.1 1.7e-28 99.6 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 KPI82470.1 - 7.8e-19 67.5 2.8 7.8e-19 67.5 2.8 2.4 2 1 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Galactosyl_T PF01762.21 KPI82473.1 - 0.003 17.4 0.5 0.0095 15.8 0.0 1.9 2 0 0 2 2 2 1 Galactosyltransferase ABC_membrane PF00664.23 KPI82474.1 - 1.2e-18 67.7 3.2 1.6e-18 67.4 3.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF4090 PF13319.6 KPI82474.1 - 0.015 15.5 0.0 0.084 13.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4090) DUF4252 PF14060.6 KPI82474.1 - 0.047 13.6 0.1 0.083 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) S-AdoMet_synt_C PF02773.16 KPI82475.1 - 2.7e-66 221.8 0.0 5.1e-66 220.9 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 KPI82475.1 - 4.8e-44 149.5 0.0 7e-44 148.9 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 KPI82475.1 - 5.5e-13 49.4 0.5 1.1e-12 48.5 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain Strep_pep PF14404.6 KPI82475.1 - 0.028 14.7 0.0 0.092 13.0 0.0 1.9 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species ABC_membrane PF00664.23 KPI82477.1 - 1.2e-18 67.8 3.1 1.3e-18 67.6 3.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Peptidase_M8 PF01457.16 KPI82478.1 - 1e-40 140.0 0.0 1.2e-40 139.8 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin AltA1 PF16541.5 KPI82478.1 - 0.058 14.2 0.0 0.098 13.5 0.0 1.4 1 0 0 1 1 1 0 Alternaria alternata allergen 1 Ribosomal_L3 PF00297.22 KPI82479.1 - 1e-128 429.4 8.0 1.2e-128 429.2 8.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 PFK PF00365.20 KPI82480.1 - 5.8e-62 209.6 0.5 6.9e-62 209.3 0.5 1.0 1 0 0 1 1 1 1 Phosphofructokinase DAGK_cat PF00781.24 KPI82480.1 - 0.00014 21.5 0.2 0.00046 19.8 0.1 1.9 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 KPI82480.1 - 0.017 14.3 0.0 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 ATP-NAD kinase Peptidase_S10 PF00450.22 KPI82482.1 - 2e-96 323.9 0.0 2.3e-96 323.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.7 KPI82482.1 - 8.9e-05 23.2 0.2 0.00064 20.4 0.2 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF116 PF01976.17 KPI82482.1 - 0.22 11.0 0.4 0.34 10.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF116 SBP_bac_3 PF00497.20 KPI82484.1 - 0.034 13.6 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 SBP_bac_3 PF00497.20 KPI82485.1 - 0.12 11.8 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 ATP_sub_h PF10775.9 KPI82486.1 - 0.0014 18.6 0.2 0.003 17.5 0.2 1.6 1 0 0 1 1 1 1 ATP synthase complex subunit h ABC_membrane PF00664.23 KPI82488.1 - 6.4e-23 81.8 11.0 8.8e-23 81.3 11.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Mit_KHE1 PF10173.9 KPI82488.1 - 1.1 9.3 3.3 1.9 8.5 3.3 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related TSP_1 PF00090.19 KPI82491.1 - 0.57 10.5 4.8 2.5 8.4 0.6 2.9 2 0 0 2 2 2 0 Thrombospondin type 1 domain HSP70 PF00012.20 KPI82492.1 - 2.8e-58 197.5 0.1 3.3e-58 197.3 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein ABC_membrane PF00664.23 KPI82493.1 - 1.6e-29 103.4 4.3 2e-29 103.1 4.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Ferric_reduct PF01794.19 KPI82494.1 - 0.052 13.7 0.2 0.052 13.7 0.2 2.2 2 1 0 2 2 2 0 Ferric reductase like transmembrane component GSHPx PF00255.19 KPI82495.1 - 6.9e-12 44.9 0.1 9.6e-12 44.4 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase FH2 PF02181.23 KPI82496.1 - 1.7e-52 178.8 0.2 2.1e-52 178.5 0.2 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Med9 PF07544.13 KPI82496.1 - 0.0033 17.5 0.1 0.0033 17.5 0.1 2.8 3 0 0 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 DUF148 PF02520.17 KPI82496.1 - 0.06 13.5 1.0 0.55 10.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF148 AAA PF00004.29 KPI82497.1 - 0.00037 20.9 0.0 0.0025 18.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Bradykinin PF06753.12 KPI82498.1 - 0.19 11.5 2.6 0.21 11.4 0.4 2.0 2 0 0 2 2 2 0 Bradykinin ABC_membrane PF00664.23 KPI82499.1 - 1.5e-29 103.5 15.3 2e-29 103.1 15.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region BT1 PF03092.16 KPI82501.1 - 3.7e-85 286.2 14.4 4e-85 286.0 14.4 1.0 1 0 0 1 1 1 1 BT1 family Polysacc_synt_C PF14667.6 KPI82501.1 - 0.25 11.4 7.7 0.072 13.1 3.9 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Atg8 PF02991.16 KPI82504.1 - 8.2e-09 35.6 0.0 1.2e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG5 PF04106.12 KPI82504.1 - 0.0053 16.4 0.0 0.0053 16.4 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 ABC_membrane PF00664.23 KPI82507.1 - 1e-27 97.5 5.3 1.4e-27 97.1 5.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region DLH PF01738.18 KPI82509.1 - 4.5e-24 85.2 0.1 5.7e-24 84.9 0.1 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KPI82509.1 - 0.0046 16.6 0.0 0.024 14.3 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Stealth_CR3 PF17102.5 KPI82510.1 - 1.2e-07 31.5 2.5 2.9e-07 30.3 2.5 1.7 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 BT1 PF03092.16 KPI82511.1 - 6.7e-102 341.4 17.3 7.8e-102 341.2 17.3 1.0 1 0 0 1 1 1 1 BT1 family Cyclin_N PF00134.23 KPI82516.1 - 5.6e-39 132.8 0.9 5.6e-39 132.8 0.9 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KPI82516.1 - 3.3e-28 98.2 0.1 8.5e-28 96.8 0.1 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain BT1 PF03092.16 KPI82517.1 - 1.8e-103 346.6 15.0 2.1e-103 346.3 15.0 1.0 1 0 0 1 1 1 1 BT1 family PEPCK_ATP PF01293.20 KPI82518.1 - 5.4e-194 645.2 0.0 6.8e-194 644.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase ATP-synt_ab PF00006.25 KPI82519.1 - 6.6e-64 215.5 0.1 2.7e-63 213.5 0.0 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KPI82519.1 - 2.4e-12 47.2 0.2 5.7e-12 46.0 0.2 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 KPI82519.1 - 0.0045 17.4 0.2 0.029 14.8 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 KPI82519.1 - 0.013 15.9 1.5 0.27 11.5 0.4 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KPI82519.1 - 0.024 14.2 0.2 0.088 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KPI82519.1 - 0.035 13.5 0.1 0.062 12.6 0.1 1.4 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.22 KPI82519.1 - 0.035 13.3 0.0 0.072 12.3 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 KPI82519.1 - 0.077 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 KPI82519.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 KPI82520.1 - 7.1e-09 36.3 0.0 9.4e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI82520.1 - 0.019 14.4 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KPI82520.1 - 0.024 14.4 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AMP-binding PF00501.28 KPI82524.1 - 1e-84 284.6 0.4 1.3e-84 284.3 0.4 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KPI82524.1 - 1.5e-13 51.5 0.0 1.5e-12 48.3 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ATP-synt_ab PF00006.25 KPI82525.1 - 4.5e-67 225.8 0.1 6.9e-67 225.2 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 KPI82525.1 - 2.4e-08 34.4 0.6 1.9e-07 31.4 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain Roc PF08477.13 KPI82525.1 - 0.13 12.5 0.1 0.52 10.5 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase EF-hand_6 PF13405.6 KPI82527.1 - 3.2e-06 26.6 0.2 0.00015 21.4 0.0 3.1 2 1 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KPI82527.1 - 7.2e-06 26.4 0.9 0.00016 22.1 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI82527.1 - 1.9e-05 23.9 3.8 0.00018 20.8 0.0 3.1 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 KPI82527.1 - 0.0016 18.2 2.6 0.75 9.7 0.2 3.2 1 1 2 3 3 3 2 EF-hand domain pair DUF1456 PF07308.13 KPI82527.1 - 0.0045 17.3 0.6 0.036 14.4 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1456) DUF2202 PF09968.9 KPI82527.1 - 0.03 14.2 0.4 0.065 13.1 0.4 1.6 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) FISNA PF14484.6 KPI82527.1 - 0.05 13.8 0.6 0.11 12.8 0.1 1.8 2 0 0 2 2 2 0 Fish-specific NACHT associated domain EF-hand_5 PF13202.6 KPI82527.1 - 0.051 13.1 0.4 0.41 10.2 0.0 2.6 2 0 0 2 2 2 0 EF hand Cg6151-P PF10233.9 KPI82529.1 - 0.028 14.7 1.2 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein CG6151-P Keratin_B2_2 PF13885.6 KPI82533.1 - 4.6 7.3 32.5 0.45 10.5 14.7 2.9 3 0 0 3 3 3 0 Keratin, high sulfur B2 protein ProRS-C_1 PF09180.11 KPI82534.1 - 1.9e-25 88.8 1.7 4.6e-25 87.6 1.7 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 KPI82534.1 - 1e-18 67.2 0.0 3.8e-18 65.4 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KPI82534.1 - 2.8e-18 66.5 0.0 4.4e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ABC2_membrane_3 PF12698.7 KPI82537.1 - 5.5e-38 131.0 19.0 6.8e-38 130.6 13.7 2.1 2 0 0 2 2 2 2 ABC-2 family transporter protein COX15-CtaA PF02628.15 KPI82537.1 - 0.0016 17.6 0.7 0.0027 16.8 0.7 1.3 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Lipase_3 PF01764.25 KPI82540.1 - 1.6e-31 109.1 0.0 2.2e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 KPI82540.1 - 8.2e-05 23.3 0.2 0.0001 23.0 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KPI82540.1 - 0.01 15.1 0.1 0.017 14.4 0.1 1.3 1 1 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 KPI82540.1 - 0.023 14.3 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Thioesterase PF00975.20 KPI82540.1 - 0.026 14.7 0.1 0.051 13.7 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.7 KPI82540.1 - 0.044 13.6 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family AMP-binding PF00501.28 KPI82541.1 - 4e-20 71.8 0.0 4.3e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme TrwC PF08751.11 KPI82541.1 - 0.33 10.4 4.5 0.085 12.4 0.5 1.7 1 1 0 2 2 2 0 TrwC relaxase AMP-binding PF00501.28 KPI82542.1 - 1.5e-14 53.4 0.0 1.9e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KPI82542.1 - 9.8e-14 52.1 0.6 2.7e-13 50.7 0.6 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M8 PF01457.16 KPI82543.1 - 6.9e-20 71.2 2.2 8e-20 71.0 2.2 1.0 1 0 0 1 1 1 1 Leishmanolysin Pex24p PF06398.11 KPI82544.1 - 0.072 12.1 0.0 0.076 12.0 0.0 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin BT1 PF03092.16 KPI82545.1 - 9.3e-16 57.1 0.1 1e-15 57.0 0.1 1.0 1 0 0 1 1 1 1 BT1 family cEGF PF12662.7 KPI82546.1 - 0.77 9.7 15.0 4.4 7.3 1.1 3.9 3 1 0 3 3 3 0 Complement Clr-like EGF-like His_Phos_2 PF00328.22 KPI82548.1 - 9.8e-08 31.7 0.1 6.1e-05 22.5 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) zf-HC5HC2H PF13771.6 KPI82549.1 - 0.061 13.6 0.6 0.087 13.1 0.6 1.2 1 0 0 1 1 1 0 PHD-like zinc-binding domain DUF5075 PF16825.5 KPI82550.1 - 7.2e-06 25.8 2.7 0.014 15.1 0.4 2.3 2 0 0 2 2 2 2 IGP family C-type lectin domain TMEM52 PF14979.6 KPI82550.1 - 0.0019 18.1 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 Transmembrane 52 OATP PF03137.20 KPI82550.1 - 0.049 11.9 0.0 0.067 11.5 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF997 PF06196.12 KPI82550.1 - 3.9 7.5 9.4 0.8 9.8 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF997) PH PF00169.29 KPI82551.1 - 7.2e-05 23.3 0.0 9.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 PH domain Flagellar_rod PF05149.12 KPI82553.1 - 2.9e-105 351.8 26.7 2.9e-105 351.8 26.7 2.1 2 0 0 2 2 2 1 Paraflagellar rod protein Spc7 PF08317.11 KPI82553.1 - 0.002 17.0 15.0 0.002 17.0 15.0 4.3 2 2 3 5 5 5 1 Spc7 kinetochore protein UPF0225 PF17775.1 KPI82553.1 - 3 8.7 9.1 4.1 8.3 1.2 3.4 2 1 0 2 2 2 0 UPF0225 domain ING PF12998.7 KPI82553.1 - 4.9 7.8 20.7 0.046 14.3 2.6 4.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding TRM13 PF05206.14 KPI82556.1 - 5.6e-07 29.4 0.1 1.4e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase TRM13 Flagellar_rod PF05149.12 KPI82557.1 - 1.1e-104 350.0 28.2 1.1e-104 350.0 28.2 2.8 2 1 1 3 3 3 2 Paraflagellar rod protein DUF1120 PF06551.12 KPI82557.1 - 0.078 13.1 0.8 0.16 12.1 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1120) TauE PF01925.19 KPI82559.1 - 3e-08 33.6 35.7 2.4e-07 30.7 32.9 2.6 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE DUF4536 PF15055.6 KPI82559.1 - 0.13 12.6 0.8 0.53 10.6 0.8 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) Orbi_VP6 PF01516.16 KPI82560.1 - 0.013 15.0 2.3 0.015 14.8 2.3 1.0 1 0 0 1 1 1 0 Orbivirus helicase VP6 Med3 PF11593.8 KPI82560.1 - 3.7 6.6 5.9 3.8 6.6 5.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Peptidase_M32 PF02074.15 KPI82561.1 - 3e-65 220.9 0.0 3.3e-65 220.7 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Ribosom_S12_S23 PF00164.25 KPI82563.1 - 3.2e-48 162.1 0.4 3.2e-48 162.1 0.4 1.5 2 0 0 2 2 2 1 Ribosomal protein S12/S23 Transketolase_N PF00456.21 KPI82565.1 - 1.6e-140 467.9 0.1 2e-140 467.5 0.1 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KPI82565.1 - 2.2e-42 144.8 0.0 3.8e-42 144.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KPI82565.1 - 8.4e-08 32.1 0.0 2.6e-07 30.5 0.0 1.8 1 1 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 KPI82565.1 - 0.00045 20.0 0.2 0.0026 17.6 0.1 2.4 2 1 1 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 KPI82565.1 - 0.0018 17.6 0.0 0.0034 16.6 0.0 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 KPI82565.1 - 0.0049 15.8 0.0 0.0079 15.2 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Terpene_synth PF01397.21 KPI82565.1 - 0.16 11.7 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain Hrs_helical PF12210.8 KPI82565.1 - 0.21 12.1 0.1 0.39 11.3 0.1 1.4 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate ABC_membrane PF00664.23 KPI82566.1 - 5.2e-52 177.2 0.3 5.8e-52 177.0 0.3 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF2852 PF11014.8 KPI82566.1 - 0.0024 18.0 0.6 0.0069 16.5 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2852) MtrC PF04211.13 KPI82566.1 - 0.0096 15.0 1.4 0.014 14.5 1.4 1.2 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit C Halogen_Hydrol PF10112.9 KPI82566.1 - 0.086 12.9 0.5 0.12 12.3 0.5 1.3 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein ABC_tran PF00005.27 KPI82567.1 - 3.9e-32 111.6 0.0 7e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI82567.1 - 3.2e-07 30.0 0.3 8.6e-06 25.3 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KPI82567.1 - 0.0009 19.7 0.9 0.003 18.0 0.4 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 KPI82567.1 - 0.0017 18.8 0.1 0.062 13.7 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 KPI82567.1 - 0.02 13.7 0.0 0.028 13.2 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_29 PF13555.6 KPI82567.1 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 KPI82567.1 - 0.12 12.6 1.8 3.1 8.1 0.6 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 KPI82567.1 - 0.14 12.0 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase NUDE_C PF04880.13 KPI82568.1 - 9.3 6.7 7.8 12 6.4 7.8 1.2 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF998 PF06197.13 KPI82569.1 - 6.7e-05 22.6 3.8 0.0001 22.0 3.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF998) CRT-like PF08627.10 KPI82569.1 - 0.092 11.7 1.6 5.5 5.8 0.4 2.0 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like GTP_EFTU_D3 PF03143.17 KPI82575.1 - 1.7e-23 83.1 0.1 5.2e-23 81.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KPI82575.1 - 2e-10 40.9 0.1 3.4e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Peptidase_M8 PF01457.16 KPI82579.1 - 8.4e-76 255.7 0.0 1.5e-75 254.9 0.0 1.3 1 1 0 1 1 1 1 Leishmanolysin eIF2_C PF09173.11 KPI82585.1 - 1.1e-12 48.1 0.0 4.2e-12 46.2 0.0 2.1 2 1 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 KPI82585.1 - 3.6e-05 24.1 2.8 6.6e-05 23.2 0.7 2.4 2 1 0 2 2 2 1 Elongation factor Tu domain 2 UFD1 PF03152.14 KPI82587.1 - 1.2e-43 148.6 0.0 1.5e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Inhibitor_I42 PF09394.10 KPI82590.1 - 1.6e-15 57.3 0.0 2.1e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 Abhydrolase_9_N PF15420.6 KPI82590.1 - 0.13 12.3 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus CGI-121 PF08617.10 KPI82591.1 - 0.002 18.3 0.2 0.0049 17.0 0.2 1.8 1 1 0 1 1 1 1 Kinase binding protein CGI-121 Cyclin_C_2 PF16899.5 KPI82591.1 - 0.089 13.2 0.1 0.2 12.1 0.1 1.6 1 0 0 1 1 1 0 Cyclin C-terminal domain Thioredoxin_8 PF13905.6 KPI82592.1 - 9.9e-37 125.2 0.0 1.2e-19 70.4 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin PF00085.20 KPI82592.1 - 1.7e-12 47.2 0.2 0.00014 21.8 0.2 4.0 4 0 0 4 4 4 2 Thioredoxin Redoxin PF08534.10 KPI82592.1 - 2.4e-12 46.8 0.0 2.1e-05 24.3 0.0 2.1 2 0 0 2 2 2 2 Redoxin AhpC-TSA PF00578.21 KPI82592.1 - 9e-10 38.5 0.1 0.00056 19.8 0.0 2.2 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.6 KPI82592.1 - 9e-06 26.1 0.3 0.057 13.9 0.1 2.5 2 1 0 2 2 2 2 Thioredoxin-like domain TraF PF13728.6 KPI82592.1 - 0.0025 17.7 0.3 0.22 11.3 0.0 2.5 2 1 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KPI82592.1 - 0.0052 16.9 0.2 0.47 10.7 0.1 2.8 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KPI82592.1 - 0.026 14.3 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin Sugar_tr PF00083.24 KPI82593.1 - 2.6e-93 313.3 33.5 5.1e-93 312.4 33.5 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KPI82593.1 - 5.9e-09 35.3 39.6 5.9e-09 35.3 39.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Gp_dh_C PF02800.20 KPI82594.1 - 4.1e-63 211.7 0.1 6.6e-63 211.0 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KPI82594.1 - 2.6e-30 104.8 0.0 5.9e-30 103.6 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KPI82594.1 - 0.087 13.4 0.0 0.3 11.7 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Sugar_tr PF00083.24 KPI82595.1 - 1.5e-100 337.2 26.6 3.9e-99 332.5 26.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KPI82595.1 - 4.5e-20 71.9 17.0 1.1e-17 64.0 18.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily YqhR PF11085.8 KPI82595.1 - 0.013 15.4 1.6 0.013 15.4 1.6 2.9 4 0 0 4 4 4 0 Conserved membrane protein YqhR DUF1772 PF08592.11 KPI82595.1 - 0.089 13.1 0.1 0.49 10.7 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) DUF3180 PF11377.8 KPI82595.1 - 3.2 7.9 8.6 0.82 9.8 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3180) Exo_endo_phos_2 PF14529.6 KPI82596.1 - 2.1e-11 43.7 0.0 2.6e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Hydrolase_6 PF13344.6 KPI82599.1 - 4e-16 59.0 0.0 9.6e-16 57.7 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KPI82599.1 - 7.9e-15 54.7 0.0 4.9e-14 52.1 0.0 2.4 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.26 KPI82599.1 - 3.1e-06 27.6 0.0 4.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KPI82599.1 - 0.0034 17.0 0.0 0.0071 16.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase HAD_2 PF13419.6 KPI82599.1 - 0.0043 17.2 0.0 0.0094 16.0 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase BT1 PF03092.16 KPI82601.1 - 0.084 11.1 0.0 0.092 10.9 0.0 1.1 1 0 0 1 1 1 0 BT1 family RVT_1 PF00078.27 KPI82602.1 - 1.1e-05 25.1 0.0 0.00039 20.0 0.0 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_11 PF16622.5 KPI82603.1 - 0.089 12.6 0.1 0.23 11.2 0.1 1.7 1 0 0 1 1 1 0 zinc-finger C2H2-type Glycos_transf_2 PF00535.26 KPI82607.1 - 1.4e-05 25.0 0.0 2.3e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 AA_permease_N PF08403.10 KPI82607.1 - 0.068 12.7 0.2 0.14 11.7 0.2 1.5 1 0 0 1 1 1 0 Amino acid permease N-terminal DUF1935 PF09149.10 KPI82608.1 - 4.7e-31 107.2 0.0 6e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Glycos_transf_2 PF00535.26 KPI82609.1 - 0.0014 18.5 0.0 0.0029 17.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Atg8 PF02991.16 KPI82610.1 - 0.0023 18.1 0.0 0.0031 17.7 0.0 1.3 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like RPA_C PF08784.11 KPI82610.1 - 0.21 12.2 0.0 0.26 12.0 0.0 1.2 1 0 0 1 1 1 0 Replication protein A C terminal Ribosomal_S5 PF00333.20 KPI82611.1 - 0.053 13.5 0.1 0.083 12.9 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain GTP_EFTU PF00009.27 KPI82612.1 - 2.7e-64 216.3 0.2 4.7e-64 215.5 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KPI82612.1 - 4.2e-29 100.8 0.0 1.2e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 KPI82612.1 - 3.3e-20 71.9 0.0 1.4e-19 69.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KPI82612.1 - 4.1e-14 52.7 0.1 1.1e-13 51.4 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KPI82612.1 - 7.3e-14 51.6 0.0 3.1e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 KPI82612.1 - 0.0023 18.0 0.1 0.0057 16.7 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Kinesin PF00225.23 KPI82613.1 - 1.9e-77 260.4 0.0 4.3e-77 259.3 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI82613.1 - 1.1e-19 70.8 0.0 3.4e-19 69.2 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding Filament PF00038.21 KPI82613.1 - 0.00012 21.8 40.0 0.00012 21.8 40.0 2.5 1 1 1 2 2 2 1 Intermediate filament protein Tropomyosin_1 PF12718.7 KPI82613.1 - 0.0016 18.6 29.7 0.0016 18.6 29.7 4.5 1 1 3 4 4 3 1 Tropomyosin like DUF5082 PF16888.5 KPI82613.1 - 0.029 14.6 0.1 0.029 14.6 0.1 4.8 3 2 1 4 4 4 0 Domain of unknown function (DUF5082) NPV_P10 PF05531.12 KPI82613.1 - 0.082 13.4 22.4 0.039 14.4 4.9 4.9 4 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 KPI82613.1 - 0.1 11.4 60.9 0.36 9.7 22.7 4.0 1 1 3 4 4 4 0 Spc7 kinetochore protein FAM76 PF16046.5 KPI82613.1 - 0.15 11.4 33.0 1.1 8.6 11.5 3.9 1 1 3 4 4 4 0 FAM76 protein Terminase_6 PF03237.15 KPI82613.1 - 0.17 11.5 4.0 11 5.6 0.3 3.1 3 0 0 3 3 3 0 Terminase-like family DUF3135 PF11333.8 KPI82613.1 - 0.46 10.8 4.3 2.9 8.2 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Baculo_PEP_C PF04513.12 KPI82613.1 - 0.73 9.9 31.2 1.3 9.1 6.5 4.6 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 KPI82613.1 - 1.6 8.7 32.2 0.049 13.7 7.8 5.3 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) ApoO PF09769.9 KPI82613.1 - 1.9 8.5 10.9 52 3.8 4.7 5.1 3 1 1 5 5 5 0 Apolipoprotein O MPS2 PF17060.5 KPI82613.1 - 2 7.6 19.2 3.3 6.9 1.7 3.0 1 1 2 3 3 3 0 Monopolar spindle protein 2 Fib_alpha PF08702.10 KPI82613.1 - 2 8.6 29.9 0.79 9.9 4.7 4.7 1 1 5 6 6 6 0 Fibrinogen alpha/beta chain family DASH_Duo1 PF08651.10 KPI82613.1 - 6.2 6.7 12.9 0.24 11.2 2.1 3.7 4 0 0 4 4 4 0 DASH complex subunit Duo1 Atg14 PF10186.9 KPI82613.1 - 7.2 5.6 36.1 0.82 8.7 12.8 2.9 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 HrpB7 PF09486.10 KPI82613.1 - 7.3 7.0 65.5 1.6 9.1 3.7 4.5 2 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) TPR_MLP1_2 PF07926.12 KPI82613.1 - 8.7 6.4 73.8 1.7 8.7 29.3 5.3 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein Sec8_exocyst PF04048.14 KPI82613.1 - 9.3 6.1 23.5 3.8 7.4 2.2 5.2 2 1 4 6 6 6 0 Sec8 exocyst complex component specific domain SelB-wing_1 PF09105.10 KPI82614.1 - 0.19 11.7 1.2 0.38 10.8 1.2 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Zip PF02535.22 KPI82615.1 - 0.031 13.5 0.3 0.036 13.3 0.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GST_C_2 PF13410.6 KPI82621.1 - 0.017 15.1 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AsnC_trans_reg PF01037.21 KPI82621.1 - 0.17 11.9 0.0 0.26 11.3 0.0 1.2 1 1 0 1 1 1 0 Lrp/AsnC ligand binding domain Nucleoside_tran PF01733.18 KPI82622.1 - 3.5e-31 108.7 1.7 2.7e-19 69.7 0.0 2.7 3 0 0 3 3 3 2 Nucleoside transporter FoP_duplication PF13865.6 KPI82623.1 - 0.15 12.7 1.0 1.5 9.4 0.1 2.2 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 LRR_4 PF12799.7 KPI82626.1 - 1.4e-07 31.7 0.0 0.0082 16.5 0.0 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82626.1 - 4.4e-07 29.6 0.0 0.00067 19.4 0.1 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 KPI82626.1 - 0.013 15.5 0.9 31 5.0 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich repeat LRRNT_2 PF08263.12 KPI82626.1 - 0.15 12.4 0.6 0.15 12.4 0.6 1.9 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain DEAD PF00270.29 KPI82628.1 - 1.1e-42 145.7 0.1 5.7e-42 143.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI82628.1 - 4.6e-28 97.8 0.5 2.4e-27 95.5 0.3 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 KPI82628.1 - 4e-05 23.1 0.2 0.00016 21.2 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 KPI82628.1 - 0.065 13.5 0.9 0.35 11.2 0.9 2.3 1 1 0 1 1 1 0 AAA domain Spectrin PF00435.21 KPI82629.1 - 0.028 14.9 1.7 1.8 9.1 0.4 2.1 2 0 0 2 2 2 0 Spectrin repeat CENP-F_leu_zip PF10473.9 KPI82629.1 - 0.031 14.3 4.2 0.063 13.3 4.2 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4530 PF15039.6 KPI82629.1 - 0.048 13.8 1.8 6.5 6.9 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4530) PikAIV_N PF18605.1 KPI82629.1 - 0.26 10.9 6.0 2.9 7.6 1.6 2.7 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain APG6_N PF17675.1 KPI82629.1 - 3.2 8.3 8.1 13 6.4 0.6 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Mto2_bdg PF12808.7 KPI82629.1 - 6.1 7.2 7.2 33 4.9 0.0 3.1 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region S1-P1_nuclease PF02265.16 KPI82632.1 - 5.3e-14 52.7 0.0 7.5e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 S1/P1 Nuclease Pkinase PF00069.25 KPI82633.1 - 2.5e-58 197.5 0.0 7.1e-58 196.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82633.1 - 1.2e-35 123.1 0.0 2.3e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI82633.1 - 1.7e-05 24.3 0.0 2.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI82633.1 - 0.00038 19.3 0.1 0.0012 17.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KPI82633.1 - 0.0038 17.2 0.0 0.0075 16.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family JAB PF01398.21 KPI82634.1 - 0.096 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Fer4_17 PF13534.6 KPI82635.1 - 5.2e-08 33.3 10.2 1.5e-06 28.7 1.8 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 KPI82635.1 - 1.6e-07 31.7 0.3 0.00027 21.3 0.3 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 KPI82635.1 - 0.00051 20.1 4.7 0.0014 18.7 4.7 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 KPI82635.1 - 0.014 15.5 4.5 0.032 14.4 1.2 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 KPI82635.1 - 0.026 15.1 3.8 0.09 13.4 3.9 1.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 KPI82635.1 - 0.047 14.2 1.0 0.047 14.2 1.0 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Peptidase_S49_N PF08496.10 KPI82636.1 - 0.049 13.7 0.0 0.066 13.3 0.0 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PPR PF01535.20 KPI82639.1 - 1.1e-07 31.5 3.8 0.0097 16.1 0.1 5.3 6 0 0 6 6 6 2 PPR repeat PPR_2 PF13041.6 KPI82639.1 - 7.6e-07 29.2 0.6 0.081 13.1 0.1 5.6 5 2 2 7 7 7 1 PPR repeat family PPR_3 PF13812.6 KPI82639.1 - 0.00011 22.1 0.0 0.091 12.9 0.0 3.4 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KPI82639.1 - 0.0075 15.7 0.8 2.5 7.4 0.0 3.7 3 1 1 4 4 4 1 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 KPI82639.1 - 0.16 12.8 23.8 28 5.9 0.1 7.5 5 1 3 8 8 8 0 Tetratricopeptide repeat PPR_1 PF12854.7 KPI82639.1 - 0.28 10.9 1.7 0.51 10.1 0.2 2.2 2 0 0 2 2 2 0 PPR repeat TMEM154 PF15102.6 KPI82640.1 - 0.6 10.0 1.7 0.95 9.4 1.7 1.3 1 0 0 1 1 1 0 TMEM154 protein family NAD_binding_6 PF08030.12 KPI82641.1 - 6.8e-05 23.0 0.0 8.8e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Ferric reductase NAD binding domain CAP_GLY PF01302.25 KPI82647.1 - 0.099 12.7 0.2 0.19 11.8 0.2 1.4 1 0 0 1 1 1 0 CAP-Gly domain DUF3902 PF13042.6 KPI82648.1 - 0.051 13.2 2.0 0.065 12.8 1.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3902) Phi_1 PF04674.12 KPI82649.1 - 0.02 14.2 0.5 0.025 13.9 0.5 1.1 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region DUF5090 PF17009.5 KPI82650.1 - 0.034 14.1 3.0 0.039 13.9 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) COX16 PF14138.6 KPI82651.1 - 0.093 13.3 0.0 0.35 11.4 0.0 2.0 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 OppC_N PF12911.7 KPI82652.1 - 0.49 10.4 2.0 0.74 9.8 2.0 1.3 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Prominin PF05478.11 KPI82652.1 - 0.94 7.3 4.4 1.2 7.0 4.4 1.1 1 0 0 1 1 1 0 Prominin Flavodoxin_5 PF12724.7 KPI82654.1 - 1.3e-42 145.5 0.2 1.7e-42 145.1 0.2 1.1 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_1 PF00258.25 KPI82654.1 - 0.015 15.5 0.1 0.026 14.7 0.1 1.4 1 0 0 1 1 1 0 Flavodoxin DUF2194 PF09960.9 KPI82654.1 - 0.044 12.1 0.2 0.056 11.8 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) DUF2070 PF09843.9 KPI82655.1 - 6 5.0 14.1 7.6 4.7 14.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Aa_trans PF01490.18 KPI82656.1 - 5.1e-40 137.4 31.9 6.4e-40 137.1 31.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein LRR_8 PF13855.6 KPI82657.1 - 1.5e-05 24.7 1.0 0.028 14.2 0.2 2.6 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI82657.1 - 0.00061 20.1 0.1 7.1 7.2 0.0 3.3 1 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRRNT_2 PF08263.12 KPI82657.1 - 0.012 15.9 0.1 0.012 15.9 0.1 2.5 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Hist_deacetyl PF00850.19 KPI82658.1 - 9.9e-76 255.1 0.1 6.6e-45 153.9 0.1 2.1 2 0 0 2 2 2 2 Histone deacetylase domain DUF3446 PF11928.8 KPI82658.1 - 4.3 7.7 11.8 1.8 8.9 6.2 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 KPI82658.1 - 6.3 6.3 13.2 12 5.4 13.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FGGY_N PF00370.21 KPI82659.1 - 1.1e-65 221.7 0.0 1.4e-65 221.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KPI82659.1 - 1.3e-56 191.5 0.3 2.7e-56 190.5 0.3 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 KPI82659.1 - 0.073 12.6 0.1 3.1 7.2 0.0 2.8 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Oxidored_FMN PF00724.20 KPI82660.1 - 1.9e-54 185.3 0.0 2.4e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF4611 PF15387.6 KPI82661.1 - 0.25 11.6 2.9 0.64 10.3 2.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF1180 PF06679.12 KPI82661.1 - 0.49 10.8 9.8 0.046 14.1 0.9 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF1180) Glyco_hydro_32N PF00251.20 KPI82662.1 - 1.4e-58 198.9 4.6 2.3e-58 198.2 4.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 KPI82662.1 - 1.5e-11 44.6 0.0 4.2e-11 43.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal PAN_1 PF00024.26 KPI82662.1 - 9.6e-05 22.3 0.4 0.00023 21.1 0.4 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 KPI82662.1 - 0.051 13.5 1.0 0.13 12.2 1.0 1.6 1 0 0 1 1 1 0 PAN domain BNR_2 PF13088.6 KPI82662.1 - 0.073 12.4 0.1 0.41 9.9 0.1 2.0 2 0 0 2 2 2 0 BNR repeat-like domain MRP-L27 PF09809.9 KPI82662.1 - 0.074 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 DUF5074 PF16819.5 KPI82662.1 - 0.25 11.4 1.9 5.2 7.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) Ldh_1_N PF00056.23 KPI82663.1 - 5.7e-38 130.2 0.4 9.3e-38 129.5 0.4 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 KPI82663.1 - 2.3e-36 125.2 0.0 3.3e-36 124.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 KPI82663.1 - 0.012 14.7 0.0 0.15 11.0 0.0 2.0 1 1 1 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Atg8 PF02991.16 KPI82664.1 - 1.6e-07 31.5 0.0 3.1e-07 30.5 0.0 1.4 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Tubulin PF00091.25 KPI82665.1 - 2.7e-64 217.0 0.0 3.7e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KPI82665.1 - 4e-50 169.2 0.0 6.7e-50 168.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KPI82665.1 - 0.0071 16.0 0.0 0.016 14.9 0.0 1.6 2 0 0 2 2 2 1 Tubulin domain RVT_1 PF00078.27 KPI82666.1 - 1e-09 38.3 0.0 2.8e-09 36.8 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PP2C PF00481.21 KPI82667.1 - 1.5e-48 165.7 0.0 5.8e-48 163.8 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KPI82667.1 - 4.5e-05 23.2 0.2 0.0031 17.2 0.1 3.0 3 0 0 3 3 3 1 Protein phosphatase 2C SH3_4 PF06347.13 KPI82672.1 - 0.088 12.7 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain DUF4115 PF13464.6 KPI82672.1 - 0.12 12.5 0.0 0.53 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4115) DUF2181 PF10223.9 KPI82674.1 - 0.014 14.9 0.1 0.61 9.5 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2181) ANAPC4_WD40 PF12894.7 KPI82675.1 - 1.7e-05 25.0 0.0 1.2 9.5 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KPI82675.1 - 0.01 15.2 0.1 3.5 6.9 0.0 3.3 2 2 1 3 3 3 2 WD40-like domain DUF2415 PF10313.9 KPI82675.1 - 0.054 13.4 0.0 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) HSP70 PF00012.20 KPI82676.1 - 4.9e-262 870.5 6.2 5.6e-262 870.3 6.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KPI82676.1 - 8.8e-14 51.0 0.0 1.3e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KPI82676.1 - 0.02 14.6 0.0 0.11 12.2 0.0 2.1 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.11 KPI82676.1 - 0.042 13.1 3.7 0.071 12.4 3.7 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 DDR PF08841.10 KPI82676.1 - 0.069 12.1 0.5 1.9 7.4 0.2 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Herpes_UL51 PF04540.13 KPI82676.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL51 protein MscS_porin PF12795.7 KPI82676.1 - 1.5 8.3 10.6 0.38 10.3 0.7 2.6 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain SR1P PF13790.6 KPI82679.1 - 0.027 14.6 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 SR1 protein DUF1422 PF07226.11 KPI82681.1 - 0.0087 16.1 3.4 0.023 14.7 3.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1422) NPR1_interact PF15699.5 KPI82681.1 - 0.048 14.3 0.0 0.085 13.5 0.0 1.3 1 0 0 1 1 1 0 NPR1 interacting Sterol-sensing PF12349.8 KPI82681.1 - 0.38 10.6 9.4 2.2 8.1 9.4 1.9 1 1 0 1 1 1 0 Sterol-sensing domain of SREBP cleavage-activation Clathrin PF00637.20 KPI82683.1 - 1e-11 44.9 0.1 8.8e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 Region in Clathrin and VPS Pep3_Vps18 PF05131.14 KPI82683.1 - 5.1e-07 29.6 0.0 0.00014 21.7 0.0 2.5 2 0 0 2 2 2 2 Pep3/Vps18/deep orange family Vps39_2 PF10367.9 KPI82683.1 - 0.00098 19.5 0.2 0.002 18.6 0.2 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 KPI82683.1 - 0.0011 18.9 1.9 0.0034 17.3 1.9 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KPI82683.1 - 0.025 14.6 1.0 0.072 13.1 1.0 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Clathrin_H_link PF13838.6 KPI82683.1 - 0.036 14.0 0.2 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 Clathrin-H-link Zn_ribbon_17 PF17120.5 KPI82683.1 - 0.21 11.2 4.4 0.047 13.3 0.4 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 KPI82683.1 - 0.23 11.8 6.3 0.055 13.8 0.9 2.6 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 KPI82683.1 - 0.48 10.3 2.2 2.5 8.0 2.3 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Esterase PF00756.20 KPI82685.1 - 2.3e-18 66.8 0.0 2.7e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 KPI82685.1 - 2.6e-06 26.9 0.0 4.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KPI82685.1 - 0.00039 20.0 0.0 0.00069 19.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KPI82685.1 - 0.0038 16.9 0.0 0.0062 16.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KPI82685.1 - 0.004 17.8 0.1 0.0077 16.8 0.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_C1 PF00112.23 KPI82686.1 - 6.2e-59 199.7 1.0 9.6e-59 199.1 1.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KPI82686.1 - 3.9e-12 46.4 0.6 6.1e-12 45.8 0.6 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KPI82686.1 - 0.00044 19.1 0.1 0.017 14.0 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family DUF5637 PF18687.1 KPI82686.1 - 0.62 10.1 8.5 5.7 7.0 1.9 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5637) DUF3086 PF11285.8 KPI82687.1 - 0.093 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) AMP-binding PF00501.28 KPI82688.1 - 6.9e-07 28.2 0.1 1.1e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 AMP-binding enzyme DUF3037 PF11236.8 KPI82688.1 - 0.034 14.6 0.1 0.047 14.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) IF2_N PF04760.15 KPI82688.1 - 0.1 12.4 0.7 1.1 9.1 0.3 2.4 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region PRTase_2 PF15609.6 KPI82688.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 1 0 1 1 1 0 Phosphoribosyl transferase CK2S PF15011.6 KPI82691.1 - 0.014 15.3 10.3 0.074 12.9 3.2 2.5 2 1 0 2 2 2 0 Casein Kinase 2 substrate Use1 PF09753.9 KPI82691.1 - 0.044 13.5 18.8 0.09 12.5 12.9 2.7 1 1 1 2 2 2 0 Membrane fusion protein Use1 DUF1759 PF03564.15 KPI82691.1 - 0.4 10.6 5.5 6.9 6.6 0.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1759) FliD_N PF02465.18 KPI82691.1 - 0.84 10.4 5.4 13 6.5 0.3 2.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF1729 PF08354.10 KPI82691.1 - 1 8.2 5.1 0.67 8.8 0.9 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1729) Spc7 PF08317.11 KPI82691.1 - 1.1 8.1 20.2 2.4 6.9 10.5 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein TMPIT PF07851.13 KPI82691.1 - 1.1 8.5 11.3 2.5 7.3 0.2 2.3 2 0 0 2 2 2 0 TMPIT-like protein CorA PF01544.18 KPI82691.1 - 2.4 7.4 9.9 1.6 8.0 3.7 2.6 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein Fzo_mitofusin PF04799.13 KPI82691.1 - 4.5 6.8 10.3 2.9 7.4 1.5 2.8 2 1 1 3 3 3 0 fzo-like conserved region EMP24_GP25L PF01105.24 KPI82691.1 - 9.6 6.1 7.4 0.31 11.0 0.4 2.1 2 2 0 2 2 2 0 emp24/gp25L/p24 family/GOLD NPA PF16469.5 KPI82691.1 - 9.6 6.8 14.9 0.21 12.1 2.4 2.8 3 1 0 3 3 3 0 Nematode polyprotein allergen ABA-1 Hydin_ADK PF17213.3 KPI82692.1 - 0.095 13.0 3.1 0.17 12.1 3.1 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Pex14_N PF04695.13 KPI82694.1 - 0.016 15.9 1.2 0.016 15.9 1.2 2.1 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ABC2_membrane_3 PF12698.7 KPI82694.1 - 0.023 13.8 0.7 0.033 13.3 0.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein RIFIN PF02009.16 KPI82694.1 - 0.082 12.8 0.2 0.12 12.2 0.2 1.1 1 0 0 1 1 1 0 Rifin Presenilin PF01080.17 KPI82694.1 - 0.12 11.1 0.5 0.18 10.5 0.5 1.3 1 0 0 1 1 1 0 Presenilin DUF4366 PF14283.6 KPI82694.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Orf78 PF06024.12 KPI82694.1 - 0.19 12.0 0.8 0.79 10.1 0.8 2.0 1 1 0 1 1 1 0 Orf78 (ac78) Zip PF02535.22 KPI82694.1 - 0.41 9.8 2.7 0.58 9.3 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Podoplanin PF05808.11 KPI82694.1 - 0.73 9.9 6.0 1.3 9.1 6.0 1.4 1 0 0 1 1 1 0 Podoplanin NPR3 PF03666.13 KPI82694.1 - 1.1 8.0 6.7 1.6 7.4 6.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 KPI82694.1 - 1.1 8.0 9.2 0.027 13.4 3.2 1.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain TMEM154 PF15102.6 KPI82694.1 - 2.2 8.2 9.6 5.7 6.8 9.6 1.7 1 1 0 1 1 1 0 TMEM154 protein family MGC-24 PF05283.11 KPI82694.1 - 4.8 7.6 14.7 0.34 11.4 9.2 1.8 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF3439 PF11921.8 KPI82694.1 - 6.2 6.8 10.8 1.9 8.5 7.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF908 PF06012.12 KPI82694.1 - 6.6 6.0 18.4 0.37 10.2 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Rhomboid PF01694.22 KPI82695.1 - 0.00031 20.8 17.3 0.0006 19.8 7.3 3.0 3 1 0 3 3 3 2 Rhomboid family Ribosomal_L21e PF01157.18 KPI82697.1 - 0.062 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L21e ABC_membrane PF00664.23 KPI82698.1 - 7.2e-12 45.5 6.2 1.1e-11 45.0 6.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region CAP_GLY PF01302.25 KPI82698.1 - 0.047 13.7 0.1 0.14 12.2 0.1 1.8 1 1 0 1 1 1 0 CAP-Gly domain Phage_holin_2_3 PF16080.5 KPI82698.1 - 0.13 12.0 0.6 0.34 10.7 0.6 1.7 1 0 0 1 1 1 0 Bacteriophage holin family HP1 GCP_C_terminal PF04130.13 KPI82699.1 - 3.6e-40 138.4 12.6 6.9e-40 137.4 12.6 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KPI82699.1 - 6.4e-34 118.0 0.4 6.4e-34 118.0 0.4 2.0 2 1 1 3 3 3 1 Gamma tubulin complex component N-terminal Pim PF16765.5 KPI82702.1 - 0.048 13.8 0.1 0.07 13.3 0.1 1.2 1 0 0 1 1 1 0 Pesticin immunity protein DUF5547 PF17701.1 KPI82702.1 - 0.062 13.2 0.2 0.087 12.7 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5547) DUF3450 PF11932.8 KPI82704.1 - 2.4 7.4 15.3 0.21 10.9 1.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 KPI82704.1 - 6.7 6.8 7.0 1.9 8.5 0.5 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Fe-ADH PF00465.19 KPI82705.1 - 1.3e-57 195.3 0.9 1.7e-57 194.9 0.9 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 KPI82705.1 - 1.6e-25 90.2 0.1 2.1e-25 89.9 0.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 KPI82705.1 - 0.0016 17.7 0.0 0.0092 15.2 0.0 2.2 1 1 0 1 1 1 1 3-dehydroquinate synthase Glycolytic PF00274.19 KPI82706.1 - 2.7e-141 470.3 0.0 3.1e-141 470.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I TB2_DP1_HVA22 PF03134.19 KPI82707.1 - 0.44 10.5 7.3 2.8 7.9 1.9 3.0 3 0 0 3 3 3 0 TB2/DP1, HVA22 family DcpS_C PF11969.8 KPI82708.1 - 0.0074 16.8 0.0 0.019 15.4 0.0 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CDC24_OB3 PF17244.2 KPI82708.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 Cyclase PF04199.13 KPI82709.1 - 3.3e-16 59.8 0.0 5.2e-16 59.1 0.0 1.3 1 1 0 1 1 1 1 Putative cyclase Phg_2220_C PF09524.10 KPI82710.1 - 0.027 14.5 1.9 0.84 9.7 0.1 2.2 1 1 1 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) Per1 PF04080.13 KPI82710.1 - 0.033 13.9 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 Per1-like family ApoLp-III PF07464.11 KPI82710.1 - 0.094 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) EPO_TPO PF00758.18 KPI82710.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Erythropoietin/thrombopoietin TTL PF03133.15 KPI82713.1 - 1.8e-43 148.8 0.0 1.6e-21 76.8 0.0 2.9 2 1 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KPI82713.1 - 0.0016 17.8 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 KPI82713.1 - 0.0026 17.1 0.0 2.2 7.5 0.0 3.0 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 KPI82713.1 - 0.093 12.8 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain tRNA-synt_1g PF09334.11 KPI82714.1 - 7.8e-96 321.2 0.6 3.9e-95 318.9 0.6 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KPI82714.1 - 1e-16 60.3 0.7 1.6e-07 30.0 1.2 3.1 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 KPI82714.1 - 3.9e-06 26.4 0.0 0.024 14.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Pcc1 PF09341.10 KPI82715.1 - 6.5e-10 39.0 0.0 9.8e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Transcription factor Pcc1 Oxidored_FMN PF00724.20 KPI82716.1 - 8.2e-74 248.9 0.0 9.5e-74 248.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family CLN3 PF02487.17 KPI82717.1 - 2.2e-45 155.4 24.4 4.1e-24 85.4 9.8 3.1 3 0 0 3 3 3 3 CLN3 protein ELO PF01151.18 KPI82720.1 - 5.3e-45 153.9 25.8 8.7e-45 153.2 25.8 1.3 1 1 0 1 1 1 1 GNS1/SUR4 family Vint PF14623.6 KPI82720.1 - 0.075 12.8 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 Hint-domain NDUFA12 PF05071.16 KPI82721.1 - 0.041 14.7 1.6 0.11 13.3 1.0 2.0 1 1 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 START PF01852.19 KPI82724.1 - 0.13 11.6 0.0 0.37 10.1 0.0 1.7 2 0 0 2 2 2 0 START domain LRR_4 PF12799.7 KPI82725.1 - 2.6e-39 132.5 1.3 0.00059 20.2 0.1 12.9 7 3 9 16 16 16 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KPI82725.1 - 1.3e-12 47.8 1.1 1.4e-07 31.5 0.1 4.3 2 1 2 5 5 5 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KPI82725.1 - 2.9e-05 23.6 4.1 4.7 6.7 0.0 5.9 3 1 2 6 6 6 2 Leucine-rich repeat LRR_1 PF00560.33 KPI82725.1 - 0.0019 18.5 11.1 12 6.9 0.0 8.0 8 0 0 8 8 8 2 Leucine Rich Repeat zf-C3HC4_2 PF13923.6 KPI82725.1 - 0.01 15.6 14.0 0.051 13.4 14.0 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Fer2_3 PF13085.6 KPI82725.1 - 0.012 15.7 2.7 0.038 14.0 1.2 2.6 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Peptidase_M20 PF01546.28 KPI82727.1 - 1.8e-24 86.6 0.1 2.8e-24 86.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI82727.1 - 2.6e-11 43.4 0.0 6e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Cyt-b5 PF00173.28 KPI82728.1 - 2.2e-07 30.9 0.0 3.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cyt-b5 PF00173.28 KPI82729.1 - 9.3e-06 25.7 0.0 1.5e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MCM3AP_GANP PF16769.5 KPI82730.1 - 0.13 10.5 0.0 0.14 10.4 0.0 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP ELFV_dehydrog PF00208.21 KPI82731.1 - 2.3e-46 158.5 0.0 4.1e-46 157.7 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 KPI82731.1 - 4.6e-16 57.6 0.0 9.6e-09 33.4 0.1 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase CLP1_N PF16573.5 KPI82731.1 - 0.015 15.5 0.0 0.045 14.0 0.0 1.8 1 0 0 1 1 1 0 N-terminal beta-sandwich domain of polyadenylation factor BT1 PF03092.16 KPI82733.1 - 7.3e-190 631.6 5.5 1.1e-189 631.0 5.5 1.2 1 0 0 1 1 1 1 BT1 family Sec20 PF03908.13 KPI82734.1 - 4.4e-05 23.3 0.7 0.00013 21.8 0.6 1.9 1 1 1 2 2 2 1 Sec20 Neur_chan_memb PF02932.16 KPI82734.1 - 0.009 16.1 0.8 0.013 15.6 0.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region AKNA PF12443.8 KPI82734.1 - 0.014 16.0 0.7 0.033 14.8 0.7 1.6 1 0 0 1 1 1 0 AT-hook-containing transcription factor ADIP PF11559.8 KPI82734.1 - 0.019 15.1 1.5 0.019 15.1 1.5 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Cytochrom_B562 PF07361.11 KPI82734.1 - 0.05 14.3 1.9 0.05 14.3 1.9 2.6 2 1 1 3 3 3 0 Cytochrome b562 FapA PF03961.13 KPI82734.1 - 0.085 11.4 2.9 0.51 8.9 0.3 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A V-SNARE_C PF12352.8 KPI82734.1 - 0.16 12.2 5.2 0.084 13.2 2.3 2.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DUF5345 PF17280.2 KPI82734.1 - 0.5 10.4 3.0 0.63 10.1 0.3 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5345) UPF0242 PF06785.11 KPI82734.1 - 0.72 9.9 8.8 0.64 10.1 1.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spectrin PF00435.21 KPI82734.1 - 2.4 8.7 11.3 1.8 9.1 4.5 2.8 2 1 1 3 3 3 0 Spectrin repeat Snapin_Pallidin PF14712.6 KPI82734.1 - 3.8 8.0 11.9 0.52 10.8 3.9 2.4 2 1 0 2 2 2 0 Snapin/Pallidin SNARE PF05739.19 KPI82734.1 - 3.8 7.6 6.3 1.3 9.1 1.1 2.8 2 1 0 2 2 2 0 SNARE domain TSNAXIP1_N PF15739.5 KPI82734.1 - 6.1 7.3 12.7 14 6.1 4.7 2.4 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Mito_carr PF00153.27 KPI82735.1 - 2.4e-33 113.9 4.0 7.2e-13 48.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Arm_vescicular PF18770.1 KPI82735.1 - 0.074 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor adh_short PF00106.25 KPI82737.1 - 1.2e-31 109.8 0.3 1.5e-25 89.8 0.1 2.4 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KPI82737.1 - 1.5e-19 70.5 0.0 1e-14 54.7 0.0 2.4 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI82737.1 - 2.1e-06 27.8 0.1 3.7e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI82737.1 - 1.2e-05 25.0 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KPI82737.1 - 0.047 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Polysacc_synt_2 PF02719.15 KPI82737.1 - 0.066 12.3 0.0 0.1 11.7 0.0 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 KPI82737.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase 4F5 PF04419.14 KPI82738.1 - 7.8e-09 36.3 7.3 1.4e-08 35.5 4.6 2.0 2 0 0 2 2 2 1 4F5 protein family zf-met2 PF12907.7 KPI82738.1 - 3.5e-07 30.2 0.2 3.5e-07 30.2 0.2 2.1 2 1 0 2 2 2 1 Zinc-binding ADK PF00406.22 KPI82738.1 - 0.051 13.7 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 Adenylate kinase zf-C2H2_4 PF13894.6 KPI82738.1 - 0.085 13.7 2.7 1.4 10.0 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Ribosomal_L34e PF01199.18 KPI82738.1 - 0.12 12.7 2.6 0.15 12.4 2.6 1.2 1 0 0 1 1 1 0 Ribosomal protein L34e Cys_rich_CWC PF14375.6 KPI82738.1 - 0.3 11.5 3.5 0.45 10.9 3.5 1.2 1 0 0 1 1 1 0 Cysteine-rich CWC Peptidase_M8 PF01457.16 KPI82739.1 - 1.8e-103 347.0 0.6 2.1e-103 346.8 0.6 1.0 1 0 0 1 1 1 1 Leishmanolysin DUF3810 PF12725.7 KPI82739.1 - 0.46 9.8 2.6 0.78 9.0 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Peptidase_M8 PF01457.16 KPI82740.1 - 1.3e-32 113.3 2.0 1.6e-32 112.9 2.0 1.1 1 0 0 1 1 1 1 Leishmanolysin ADH_N PF08240.12 KPI82741.1 - 0.019 14.9 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Varsurf_PPLC PF03490.13 KPI82742.1 - 0.065 13.2 0.8 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 Variant-surface-glycoprotein phospholipase C Metallophos PF00149.28 KPI82743.1 - 3.1e-32 112.7 0.0 3.9e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI82743.1 - 1.2e-05 25.6 0.0 2.2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain EF1_GNE PF00736.19 KPI82744.1 - 1.1e-26 92.8 1.0 2e-26 92.0 1.0 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain DUF3275 PF11679.8 KPI82744.1 - 3 7.8 11.2 6.8 6.6 10.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3275) Med3 PF11593.8 KPI82744.1 - 8.7 5.4 7.0 11 5.0 7.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PH PF00169.29 KPI82745.1 - 1.1e-08 35.5 0.0 2.1e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KPI82745.1 - 0.014 15.8 0.0 0.073 13.5 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 KPI82745.1 - 0.019 15.4 0.0 0.061 13.7 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain PH_6 PF15406.6 KPI82745.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Shisa PF13908.6 KPI82747.1 - 0.004 17.4 11.0 0.012 15.8 10.7 1.9 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Sarcoglycan_2 PF05510.13 KPI82747.1 - 0.007 15.2 0.1 0.0084 14.9 0.1 1.2 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Baculo_11_kDa PF06143.11 KPI82747.1 - 0.031 13.8 0.7 0.031 13.8 0.7 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family Comm PF15957.5 KPI82747.1 - 0.044 14.1 0.2 0.078 13.3 0.2 1.4 1 0 0 1 1 1 0 Commissureless ECSCR PF15820.5 KPI82747.1 - 0.13 12.1 0.6 0.22 11.4 0.6 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator SMN PF06003.12 KPI82747.1 - 0.56 9.4 4.9 0.29 10.3 1.7 1.9 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) TFIIA PF03153.13 KPI82747.1 - 1.4 8.8 7.6 1.8 8.5 7.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GRAM PF02893.20 KPI82748.1 - 5.7e-08 32.6 0.0 1.4e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 GRAM domain MAD PF05557.13 KPI82748.1 - 0.021 13.2 7.1 0.029 12.8 7.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein GPAT_N PF14829.6 KPI82748.1 - 0.086 12.8 0.2 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal Cdh1_DBD_1 PF18196.1 KPI82748.1 - 0.16 12.3 3.1 0.086 13.2 0.7 1.8 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 CDC37_N PF03234.14 KPI82748.1 - 0.43 11.5 5.7 0.28 12.1 3.4 1.7 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DUF1664 PF07889.12 KPI82748.1 - 0.45 10.6 4.4 2.4 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Med17 PF10156.9 KPI82748.1 - 1.3 7.7 7.3 2 7.0 7.3 1.2 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Fe_hyd_lg_C PF02906.14 KPI82749.1 - 5.3e-53 180.2 0.3 2.4e-51 174.8 0.0 2.3 2 0 0 2 2 2 2 Iron only hydrogenase large subunit, C-terminal domain DGF-1_5 PF11038.8 KPI82750.1 - 0.066 12.5 0.9 0.079 12.3 0.9 1.1 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 TB2_DP1_HVA22 PF03134.19 KPI82751.1 - 6 6.9 12.9 4.3 7.3 2.8 3.7 3 1 1 4 4 4 0 TB2/DP1, HVA22 family YaeQ PF07152.12 KPI82753.1 - 0.085 12.5 0.2 14 5.3 0.1 2.6 2 0 0 2 2 2 0 YaeQ protein Sfi1_C PF10638.9 KPI82753.1 - 0.12 13.1 0.2 0.29 11.9 0.2 1.6 1 0 0 1 1 1 0 Spindle body associated protein C-terminus Cation_ATPase_C PF00689.21 KPI82755.1 - 1.8e-17 63.7 7.2 2.1e-17 63.4 7.2 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Frag1 PF10277.9 KPI82755.1 - 0.2 11.1 6.2 0.29 10.6 6.2 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family JAB PF01398.21 KPI82756.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myc-LZ PF02344.15 KPI82756.1 - 0.26 11.4 3.0 18 5.5 2.1 2.4 2 0 0 2 2 2 0 Myc leucine zipper domain LRR_4 PF12799.7 KPI82758.1 - 1.3e-09 38.1 3.7 0.92 10.0 0.0 7.1 4 2 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI82758.1 - 0.034 14.2 1.3 46 4.4 0.0 4.8 4 0 0 4 4 4 0 Leucine Rich repeat PHO4 PF01384.20 KPI82759.1 - 2.1e-28 99.3 0.3 2.4e-28 99.2 0.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family Cytadhesin_P30 PF07271.11 KPI82759.1 - 0.18 11.4 0.0 0.23 11.0 0.0 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 RVT_1 PF00078.27 KPI82760.1 - 2.2e-20 73.1 0.0 4.1e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IKKbetaNEMObind PF12179.8 KPI82760.1 - 0.12 12.4 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain zf-C2H2_12 PF18658.1 KPI82760.1 - 0.13 11.8 0.1 2.2 7.9 0.0 3.0 2 0 0 2 2 2 0 Zinc-finger C2H2-type SMN PF06003.12 KPI82760.1 - 2.3 7.4 5.1 6.2 6.0 5.1 1.7 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Glyco_transf_15 PF01793.16 KPI82761.1 - 0.0034 16.7 6.0 0.37 10.0 0.1 3.6 4 0 0 4 4 4 3 Glycolipid 2-alpha-mannosyltransferase AMP-binding PF00501.28 KPI82768.1 - 2.2e-92 309.9 0.1 2.8e-92 309.5 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF2675 PF11247.8 KPI82768.1 - 0.049 13.8 0.0 0.29 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2675) Amastin PF07344.11 KPI82769.1 - 0.00091 19.1 14.6 0.00091 19.1 14.6 1.9 1 1 0 1 1 1 1 Amastin surface glycoprotein SH3_9 PF14604.6 KPI82770.1 - 0.00021 21.1 0.0 0.0071 16.2 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain Mce4_CUP1 PF11887.8 KPI82770.1 - 0.036 13.5 0.1 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative SH3_2 PF07653.17 KPI82770.1 - 0.037 13.7 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Variant SH3 domain DUF3019 PF11456.8 KPI82770.1 - 0.07 13.6 0.5 0.21 12.1 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3019) Lyase_1 PF00206.20 KPI82772.1 - 7.3e-51 173.4 0.0 1.1e-50 172.8 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 KPI82772.1 - 1e-46 157.7 0.0 2.6e-46 156.5 0.0 1.7 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal N_Asn_amidohyd PF14736.6 KPI82773.1 - 3e-05 23.3 1.3 0.5 9.5 0.0 4.0 4 0 0 4 4 4 3 Protein N-terminal asparagine amidohydrolase Synaptobrevin PF00957.21 KPI82776.1 - 5.2e-14 51.8 0.1 9.3e-14 51.0 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KPI82776.1 - 6.7e-07 29.3 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain ACP_PD PF04336.12 KPI82776.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.5 1 1 0 1 1 1 0 Acyl carrier protein phosphodiesterase Ydr279_N PF17745.1 KPI82777.1 - 3.1e-09 36.9 0.0 7.2e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RNase_H2-Ydr279 PF09468.10 KPI82777.1 - 0.0046 17.2 0.0 0.0074 16.5 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF962 PF06127.11 KPI82778.1 - 1.6e-24 85.8 0.1 1.9e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF962) DUF962 PF06127.11 KPI82779.1 - 3.2e-23 81.6 0.1 3.9e-23 81.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF962) BAAT_C PF08840.11 KPI82779.1 - 0.032 14.1 0.1 0.035 14.0 0.1 1.1 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal UCR_Fe-S_N PF10399.9 KPI82779.1 - 0.26 10.7 0.2 0.26 10.7 0.2 2.1 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal LRR_4 PF12799.7 KPI82782.1 - 2.6e-15 56.3 0.0 0.11 12.9 0.0 7.7 5 4 2 8 8 8 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KPI82782.1 - 0.019 14.9 0.0 6.1 6.8 0.0 3.6 3 1 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) Beta_elim_lyase PF01212.21 KPI82783.1 - 2.2e-32 112.5 0.7 2.7e-32 112.2 0.7 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 KPI82783.1 - 4.3e-07 29.2 0.1 6.7e-07 28.6 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 KPI82783.1 - 1.4e-06 27.8 0.1 1.6e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II polyprenyl_synt PF00348.17 KPI82784.1 - 9.6e-61 205.1 0.0 1.2e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase SKIP_SNW PF02731.15 KPI82785.1 - 1.2e-07 31.5 5.1 1.2e-07 31.5 5.1 3.1 3 1 1 4 4 4 1 SKIP/SNW domain Mit_KHE1 PF10173.9 KPI82785.1 - 0.9 9.6 2.9 2.2 8.3 2.9 1.7 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Amastin PF07344.11 KPI82786.1 - 5.1e-44 149.9 12.2 5.9e-44 149.6 12.2 1.0 1 0 0 1 1 1 1 Amastin surface glycoprotein DUF347 PF03988.12 KPI82786.1 - 0.013 15.7 0.5 0.013 15.7 0.5 3.7 3 1 0 3 3 3 0 Repeat of Unknown Function (DUF347) DUF2784 PF10861.8 KPI82786.1 - 1 9.4 11.1 0.16 12.0 5.4 2.0 2 0 0 2 2 2 0 Protein of Unknown function (DUF2784) Ank_2 PF12796.7 KPI82788.1 - 8.3e-48 160.9 0.1 6.9e-12 45.8 0.0 10.7 10 1 0 11 11 11 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI82788.1 - 3.2e-39 132.8 4.8 4.9e-08 33.4 0.0 13.5 11 3 4 15 15 15 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI82788.1 - 2.6e-34 113.3 17.4 0.00044 20.5 0.0 15.7 16 0 0 16 16 16 9 Ankyrin repeat Ank_5 PF13857.6 KPI82788.1 - 1.6e-23 82.5 3.4 0.0017 18.6 0.0 10.6 9 2 2 11 11 11 6 Ankyrin repeats (many copies) Ank PF00023.30 KPI82788.1 - 1.2e-22 79.2 20.7 0.00056 20.2 0.0 15.8 16 0 0 16 16 16 4 Ankyrin repeat CDC27 PF09507.10 KPI82789.1 - 8.1 5.7 17.4 0.52 9.6 4.0 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 CytB6-F_Fe-S PF08802.10 KPI82790.1 - 0.29 11.2 3.4 0.6 10.2 0.1 3.0 2 1 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit TMEM174 PF15029.6 KPI82792.1 - 0.81 9.4 2.9 2.5 7.7 2.9 1.9 1 0 0 1 1 1 0 Transmembrane protein 174 HCV_capsid PF01543.17 KPI82793.1 - 0.017 15.3 6.2 0.022 15.0 6.2 1.1 1 0 0 1 1 1 0 Hepatitis C virus capsid protein LZ_Tnp_IS66 PF13007.7 KPI82793.1 - 0.11 13.3 2.1 0.18 12.6 2.1 1.3 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain NPV_P10 PF05531.12 KPI82794.1 - 0.56 10.7 5.9 20 5.7 0.0 4.4 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein LRR_4 PF12799.7 KPI82795.1 - 5.4e-07 29.8 4.6 0.0069 16.8 0.6 2.4 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82795.1 - 3.1e-06 26.9 15.2 4.1e-05 23.3 5.5 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 KPI82795.1 - 0.00068 19.8 4.9 4.1 8.3 0.4 4.1 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 KPI82795.1 - 0.0021 18.0 3.3 3.2 8.0 0.2 3.4 3 0 0 3 3 3 2 Leucine Rich repeat DUF5063 PF16702.5 KPI82796.1 - 0.048 14.0 0.3 0.22 11.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5063) FlaC_arch PF05377.11 KPI82796.1 - 0.06 13.7 0.0 0.63 10.5 0.0 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CysG_dimeriser PF10414.9 KPI82796.1 - 0.11 12.3 2.8 0.19 11.5 0.6 2.7 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region Acetyltransf_1 PF00583.25 KPI82797.1 - 1.2e-10 41.7 0.0 1.9e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI82797.1 - 5.2e-07 30.0 0.0 9.9e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KPI82797.1 - 0.00014 21.8 0.1 0.0006 19.8 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI82797.1 - 0.00017 21.5 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 KPI82797.1 - 0.036 13.8 0.0 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Diphthamide_syn PF01866.17 KPI82800.1 - 1.2e-112 376.3 0.0 1.5e-112 375.9 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein RTT107_BRCT_5 PF16770.5 KPI82801.1 - 7.6e-07 28.9 0.0 2.6e-06 27.2 0.0 1.9 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 KPI82801.1 - 6.9e-06 25.9 0.5 0.33 10.9 0.0 5.1 5 0 0 5 5 5 2 twin BRCT domain BRCT PF00533.26 KPI82801.1 - 2.1e-05 24.8 0.0 6.1 7.3 0.0 4.6 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain BRCT_3 PF18428.1 KPI82801.1 - 0.00076 19.5 1.7 12 6.1 0.1 4.3 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KPI82801.1 - 0.00077 19.8 0.0 7.2 7.1 0.0 4.1 4 0 0 4 4 4 1 BRCT domain, a BRCA1 C-terminus domain RAP1 PF07218.11 KPI82801.1 - 2.3 6.4 4.0 3.9 5.6 4.0 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Choline_kinase PF01633.20 KPI82802.1 - 9.5e-32 110.3 0.0 3.3e-31 108.5 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KPI82802.1 - 1.4e-08 35.0 0.1 4e-05 23.6 0.0 3.2 2 1 0 2 2 2 2 Phosphotransferase enzyme family Colicin PF01024.19 KPI82803.1 - 0.26 11.2 1.4 0.46 10.4 1.4 1.3 1 0 0 1 1 1 0 Colicin pore forming domain Fib_alpha PF08702.10 KPI82804.1 - 0.016 15.4 0.4 0.016 15.4 0.4 3.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Phage_head_chap PF11113.8 KPI82804.1 - 0.054 13.6 0.0 0.25 11.5 0.0 2.2 1 0 0 1 1 1 0 Head assembly gene product HHH_2 PF12826.7 KPI82804.1 - 0.074 13.2 0.1 0.28 11.3 0.1 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF4946 PF16304.5 KPI82804.1 - 0.29 10.9 5.1 2.8 7.6 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4946) Golgin_A5 PF09787.9 KPI82804.1 - 9.3 5.6 33.4 9.3 5.6 6.3 3.4 2 1 2 4 4 4 0 Golgin subfamily A member 5 DnaJ PF00226.31 KPI82807.1 - 1.8e-19 69.6 0.1 2.7e-19 69.0 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Shisa PF13908.6 KPI82807.1 - 0.00076 19.8 0.1 0.043 14.1 0.1 2.4 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator Tmemb_185A PF10269.9 KPI82807.1 - 0.0066 16.2 12.6 0.086 12.5 11.7 2.8 1 1 1 2 2 2 1 Transmembrane Fragile-X-F protein NCOA_u2 PF16665.5 KPI82807.1 - 0.15 12.4 8.2 0.19 12.0 0.8 2.6 2 0 0 2 2 2 0 Unstructured region on nuclear receptor coactivator protein 2TM PF13239.6 KPI82807.1 - 0.69 10.3 1.9 1 9.7 0.2 2.1 2 0 0 2 2 2 0 2TM domain ABC2_membrane_3 PF12698.7 KPI82809.1 - 4.5e-22 78.6 22.5 4.5e-22 78.6 22.5 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC2_membrane PF01061.24 KPI82809.1 - 0.01 15.2 0.9 0.01 15.2 0.9 2.8 2 1 0 2 2 2 0 ABC-2 type transporter Kinesin PF00225.23 KPI82810.1 - 4.1e-82 275.8 0.1 7e-82 275.0 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI82810.1 - 2.8e-12 46.8 0.0 6.5e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding OMS28_porin PF03532.13 KPI82810.1 - 0.17 11.1 1.6 0.26 10.5 0.1 2.0 2 0 0 2 2 2 0 OMS28 porin AAA_16 PF13191.6 KPI82810.1 - 1 9.7 8.7 11 6.4 0.0 4.0 3 0 0 3 3 3 0 AAA ATPase domain SNF2_N PF00176.23 KPI82811.1 - 2.1e-46 158.2 0.2 2.3e-45 154.9 0.1 2.4 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI82811.1 - 4.4e-11 43.1 0.0 5.1e-07 30.0 0.0 3.3 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 KPI82811.1 - 2.4e-09 37.4 0.0 4.8e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KPI82811.1 - 6.8e-06 25.5 0.1 9.8e-05 21.7 0.1 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 KPI82811.1 - 0.0023 18.2 0.0 0.011 16.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain SWI2_SNF2 PF18766.1 KPI82811.1 - 0.021 14.5 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_19 PF13245.6 KPI82811.1 - 0.11 12.9 0.2 0.35 11.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_34 PF13872.6 KPI82811.1 - 0.13 11.1 0.1 0.26 10.1 0.1 1.4 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 LAX PF15681.5 KPI82811.1 - 0.23 10.2 1.5 0.29 9.9 0.1 1.7 2 0 0 2 2 2 0 Lymphocyte activation family X Dak1 PF02733.17 KPI82814.1 - 1.3e-90 303.5 2.1 1.8e-90 303.0 2.1 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 KPI82814.1 - 7.3e-36 123.7 0.7 7.3e-36 123.7 0.7 1.8 2 0 0 2 2 2 1 DAK2 domain adh_short PF00106.25 KPI82815.1 - 2.7e-10 40.0 0.9 7.6e-10 38.6 0.9 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI82815.1 - 2.8e-08 33.6 2.1 7.2e-08 32.3 2.1 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 KPI82815.1 - 0.0005 19.6 0.3 0.0014 18.2 0.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SSI PF00720.17 KPI82815.1 - 0.095 12.7 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 Subtilisin inhibitor-like ESSS PF10183.9 KPI82816.1 - 5.7e-18 65.1 4.0 6.8e-18 64.8 4.0 1.2 1 1 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) COPI_C PF06957.11 KPI82817.1 - 5.2e-96 321.9 0.0 6.7e-96 321.5 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 KPI82817.1 - 5.7e-94 315.7 0.0 8.2e-94 315.2 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 KPI82817.1 - 3.5e-43 144.7 18.2 1.8e-07 31.7 0.4 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI82817.1 - 0.001 19.3 1.4 0.8 10.0 0.0 4.4 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_14 PF13428.6 KPI82817.1 - 3.7 8.6 10.4 21 6.3 0.6 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF1180 PF06679.12 KPI82818.1 - 2.1 8.8 6.0 3.4 8.0 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Pkinase PF00069.25 KPI82819.1 - 1.5e-46 158.9 0.0 7.6e-46 156.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82819.1 - 6.3e-28 97.8 0.0 9.2e-28 97.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI82819.1 - 3.6e-07 29.3 0.0 5.2e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KPI82819.1 - 2.7e-06 26.9 0.0 4.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI82819.1 - 0.015 15.3 1.0 0.47 10.3 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family SNAP PF14938.6 KPI82820.1 - 3.3e-14 53.0 6.0 2.1e-11 43.8 1.5 2.6 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP DHR-2 PF06920.13 KPI82820.1 - 0.0088 14.7 0.8 0.014 14.1 0.8 1.2 1 0 0 1 1 1 1 Dock homology region 2 TPR_6 PF13174.6 KPI82820.1 - 0.17 12.6 0.5 6.1 7.7 0.2 3.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI82820.1 - 0.34 11.0 2.0 5.6 7.2 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI82820.1 - 1.9 8.5 4.9 0.78 9.7 0.7 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-HIT PF04438.16 KPI82821.1 - 1e-07 31.7 6.7 2e-07 30.8 6.7 1.5 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 KPI82821.1 - 0.011 15.8 4.4 0.025 14.7 4.4 1.5 1 0 0 1 1 1 0 MYND finger Adaptin_N PF01602.20 KPI82822.1 - 1.3e-80 271.4 0.0 1.7e-80 271.1 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KPI82822.1 - 2.4e-21 76.4 0.0 1.3e-20 74.0 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KPI82822.1 - 2.6e-07 30.9 4.1 0.075 13.4 0.2 4.9 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 KPI82822.1 - 0.023 14.9 7.0 14 6.2 0.1 5.9 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.6 KPI82822.1 - 0.024 15.1 8.4 1.6 9.3 0.0 5.1 5 1 1 6 6 6 0 HEAT-like repeat Ribosomal_S9 PF00380.19 KPI82823.1 - 0.00066 20.2 0.0 0.0014 19.1 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S9/S16 WD40_4 PF16300.5 KPI82824.1 - 4.8e-11 42.4 0.1 1.2e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.11 KPI82824.1 - 4.7e-10 39.2 0.1 8.4e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 KPI82824.1 - 4.8e-06 26.8 0.2 2.6e-05 24.4 0.1 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain CR6_interact PF10147.9 KPI82824.1 - 0.026 14.2 1.5 0.043 13.5 1.5 1.2 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF641 PF04859.12 KPI82824.1 - 0.073 13.4 0.3 0.14 12.5 0.3 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) TPD52 PF04201.15 KPI82824.1 - 0.095 12.3 2.5 0.086 12.4 0.4 1.8 2 0 0 2 2 2 0 Tumour protein D52 family WD40 PF00400.32 KPI82824.1 - 0.11 13.5 11.2 0.91 10.5 0.1 5.0 4 1 0 4 4 4 0 WD domain, G-beta repeat UL11 PF11094.8 KPI82824.1 - 0.13 12.1 0.2 0.35 10.8 0.2 1.7 1 0 0 1 1 1 0 Membrane-associated tegument protein PKcGMP_CC PF16808.5 KPI82824.1 - 0.15 12.0 2.5 0.4 10.6 2.5 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Dpy-30 PF05186.13 KPI82825.1 - 2.1e-13 49.7 0.3 3.7e-13 48.9 0.3 1.4 1 0 0 1 1 1 1 Dpy-30 motif FYVE PF01363.21 KPI82826.1 - 4.2e-19 68.4 11.7 4.2e-19 68.4 11.7 4.4 3 1 0 3 3 3 1 FYVE zinc finger zf-RanBP PF00641.18 KPI82826.1 - 1.5e-17 62.6 52.1 2.2e-06 26.9 1.4 6.9 7 0 0 7 7 7 5 Zn-finger in Ran binding protein and others DZR PF12773.7 KPI82826.1 - 7.9e-07 29.0 43.8 0.075 13.1 9.5 5.7 3 2 2 5 5 5 4 Double zinc ribbon Vps36-NZF-N PF16988.5 KPI82826.1 - 0.00055 19.3 39.1 0.053 12.9 0.6 7.1 7 2 0 7 7 7 4 Vacuolar protein sorting 36 NZF-N zinc-finger domain TFIIA PF03153.13 KPI82826.1 - 1.2 9.0 10.1 1.4 8.8 7.5 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Baculo_IE-1 PF05290.11 KPI82826.1 - 8.6 6.3 11.7 0.22 11.5 4.6 2.0 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Oxidored_FMN PF00724.20 KPI82827.1 - 1.7e-66 224.8 0.0 2.1e-66 224.5 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 KPI82827.1 - 1.5e-05 24.2 0.0 2.1e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) MR_MLE_C PF13378.6 KPI82827.1 - 0.054 13.1 0.1 0.15 11.6 0.1 1.9 1 1 0 1 1 1 0 Enolase C-terminal domain-like Cupin_5 PF06172.11 KPI82828.1 - 9.7e-43 145.7 0.0 1.2e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) DUF2370 PF10176.9 KPI82828.1 - 0.22 11.1 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) zf-CCCH PF00642.24 KPI82829.1 - 7.1e-07 29.0 1.5 1.3e-06 28.2 1.5 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI82829.1 - 0.021 14.9 0.6 0.021 14.9 0.6 1.7 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_4 PF18044.1 KPI82829.1 - 0.064 13.1 1.2 0.13 12.1 1.2 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 KPI82829.1 - 0.091 13.3 1.5 0.091 13.3 1.5 1.9 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KPI82829.1 - 0.24 12.1 5.1 0.14 12.9 1.1 2.3 2 0 0 2 2 2 0 Torus domain VSP PF03302.13 KPI82830.1 - 2.8e-05 23.2 15.8 0.0025 16.7 15.9 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 KPI82830.1 - 0.0061 16.7 13.0 0.19 11.9 2.5 2.1 1 1 1 2 2 2 2 Furin-like repeat, cysteine-rich cEGF PF12662.7 KPI82830.1 - 1.1 9.3 11.9 1.8 8.6 3.0 2.9 3 1 0 3 3 3 0 Complement Clr-like EGF-like Prok-RING_2 PF14445.6 KPI82830.1 - 1.5 9.1 12.6 0.91 9.7 10.6 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 2 Tnp_zf-ribbon_2 PF13842.6 KPI82831.1 - 0.0037 18.0 2.2 0.0037 18.0 2.2 5.0 3 2 1 4 4 4 1 DDE_Tnp_1-like zinc-ribbon cEGF PF12662.7 KPI82831.1 - 0.0061 16.5 14.8 0.36 10.8 2.6 4.3 3 0 0 3 3 3 2 Complement Clr-like EGF-like VSP PF03302.13 KPI82831.1 - 0.0098 14.8 39.2 0.044 12.6 19.2 3.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein Complex1_LYR PF05347.15 KPI82832.1 - 8.6e-10 38.5 0.5 1.5e-09 37.8 0.5 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF3336 PF11815.8 KPI82833.1 - 2.4e-19 69.4 0.0 4.4e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KPI82833.1 - 6.8e-11 42.7 0.1 1.5e-10 41.6 0.1 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Metallophos PF00149.28 KPI82834.1 - 1.5e-07 32.1 0.0 2.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KPI82834.1 - 5e-05 23.6 0.0 0.0036 17.5 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Shisa PF13908.6 KPI82835.1 - 0.094 13.0 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Peptidase_S49_N PF08496.10 KPI82835.1 - 0.13 12.3 0.1 0.26 11.3 0.0 1.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal zf-C3HC4_3 PF13920.6 KPI82839.1 - 5e-13 48.7 11.3 6.5e-13 48.3 11.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI82839.1 - 0.00015 21.6 12.0 0.00022 21.0 12.0 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KPI82839.1 - 0.0036 17.1 10.2 0.0055 16.5 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) IU_nuc_hydro PF01156.19 KPI82840.1 - 7.6e-70 235.9 1.9 8.6e-70 235.7 1.9 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LRR_4 PF12799.7 KPI82844.1 - 1.2e-18 66.9 4.0 0.043 14.3 0.0 9.7 7 3 2 9 9 9 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82844.1 - 1.6e-06 27.8 7.1 0.054 13.3 0.0 7.1 7 1 0 7 7 7 3 Leucine rich repeat LRR_6 PF13516.6 KPI82844.1 - 1.6 9.0 11.7 82 3.7 0.0 7.4 8 0 0 8 8 8 0 Leucine Rich repeat zf-C3HC4_3 PF13920.6 KPI82845.1 - 1.6e-06 27.9 16.6 1.6e-06 27.9 16.6 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI82845.1 - 0.0094 16.3 12.3 0.0094 16.3 12.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KPI82845.1 - 0.0094 15.9 12.2 0.031 14.2 12.2 1.9 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KPI82845.1 - 0.11 12.3 13.8 1.1 9.1 13.8 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Sugar_tr PF00083.24 KPI82846.1 - 1e-77 261.9 26.9 4e-76 256.7 26.9 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KPI82846.1 - 5.8e-19 68.2 16.4 3.7e-17 62.3 17.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily PIF1 PF05970.14 KPI82848.1 - 1.5e-38 132.9 0.3 2.7e-29 102.5 0.0 3.9 3 1 0 3 3 3 3 PIF1-like helicase AAA_30 PF13604.6 KPI82848.1 - 7.3e-14 51.9 0.0 3.8e-12 46.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KPI82848.1 - 1.9e-12 47.7 0.0 1.7e-11 44.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI82848.1 - 0.00021 21.6 0.0 0.0017 18.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KPI82848.1 - 0.00028 20.6 0.1 0.0009 19.0 0.0 1.9 2 0 0 2 2 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 KPI82848.1 - 0.0003 20.6 0.0 5.2 6.7 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 KPI82848.1 - 0.001 19.5 0.1 0.0029 18.0 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain AAA_11 PF13086.6 KPI82848.1 - 0.0014 18.5 0.0 0.32 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 KPI82848.1 - 0.0021 17.0 0.1 0.0038 16.2 0.1 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain Herpes_Helicase PF02689.14 KPI82848.1 - 0.0022 16.0 0.0 0.035 12.1 0.0 2.0 2 0 0 2 2 2 1 Helicase NTPase_1 PF03266.15 KPI82848.1 - 0.0025 17.8 0.0 0.71 9.8 0.0 2.3 2 0 0 2 2 2 1 NTPase DEAD PF00270.29 KPI82848.1 - 0.003 17.3 0.0 2.8 7.7 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Mg_chelatase PF01078.21 KPI82848.1 - 0.025 14.0 0.1 0.052 12.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 KPI82848.1 - 0.033 13.4 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 KPI82848.1 - 0.044 13.8 0.0 5 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 KPI82848.1 - 0.081 12.3 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 KPI82848.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain UvrD-helicase PF00580.21 KPI82848.1 - 0.098 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 KPI82848.1 - 0.11 11.6 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_32 PF13654.6 KPI82848.1 - 0.21 10.3 0.0 0.34 9.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 KPI82849.1 - 1.1e-62 211.8 0.0 1.3e-62 211.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82849.1 - 1.7e-27 96.4 0.0 7.7e-27 94.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI82849.1 - 0.0014 18.0 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI82849.1 - 0.0023 17.3 0.0 0.0042 16.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ENTH PF01417.20 KPI82850.1 - 3.5e-06 27.1 0.0 0.0035 17.4 0.0 2.7 2 1 0 2 2 2 2 ENTH domain ANTH PF07651.16 KPI82850.1 - 3.8e-06 26.1 0.1 8.8e-06 24.9 0.1 1.6 1 0 0 1 1 1 1 ANTH domain WD40 PF00400.32 KPI82851.1 - 3.7e-30 103.5 26.7 1.4e-05 25.7 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI82851.1 - 1.5e-06 28.4 0.0 0.11 12.8 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nop25 PF09805.9 KPI82851.1 - 0.068 13.6 6.4 0.12 12.9 6.4 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) NAC PF01849.18 KPI82852.1 - 1.1e-15 57.3 0.1 3.1e-15 55.9 0.1 1.8 1 0 0 1 1 1 1 NAC domain Myc_N PF01056.18 KPI82852.1 - 0.044 13.7 3.3 0.049 13.5 3.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Ribosomal_60s PF00428.19 KPI82852.1 - 0.05 14.2 12.0 0.05 14.2 12.0 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Ribosomal_L16 PF00252.18 KPI82853.1 - 1e-38 132.3 0.3 1.3e-38 132.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF1490 PF07371.12 KPI82853.1 - 0.025 14.7 0.1 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1490) DUF3212 PF11486.8 KPI82853.1 - 0.16 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) WASH_WAHD PF11945.8 KPI82854.1 - 2.2e-06 27.4 0.0 3.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 WAHD domain of WASH complex DUF974 PF06159.13 KPI82855.1 - 4.1e-06 26.8 0.0 7.7e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF974) Exo_endo_phos PF03372.23 KPI82856.1 - 0.0044 16.6 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PEP-utilizers_C PF02896.18 KPI82857.1 - 4.2e-36 124.6 0.0 4.8e-36 124.4 0.0 1.0 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 KPI82858.1 - 8.5e-67 225.7 0.0 2.8e-64 217.5 0.0 2.1 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers_C PF02896.18 KPI82858.1 - 4.9e-41 140.8 0.1 8.1e-41 140.0 0.1 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilizers PF00391.23 KPI82858.1 - 1.2e-27 95.5 1.0 2.3e-27 94.5 1.0 1.5 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HTH_AsnC-type PF13404.6 KPI82858.1 - 0.0094 15.8 0.1 0.026 14.3 0.1 1.8 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 KPI82858.1 - 0.031 13.8 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 KPI82858.1 - 0.056 13.0 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 DUF3788 PF12663.7 KPI82858.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) HTH_11 PF08279.12 KPI82858.1 - 0.066 13.2 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 HTH domain MarR_2 PF12802.7 KPI82858.1 - 0.13 12.1 0.0 0.52 10.2 0.0 2.0 1 0 0 1 1 1 0 MarR family Pkinase PF00069.25 KPI82859.1 - 3.2e-53 180.8 0.0 2.3e-49 168.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82859.1 - 1.3e-33 116.4 0.0 1e-29 103.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI82859.1 - 9.4e-06 25.1 0.0 1.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI82859.1 - 0.00036 20.5 0.2 0.0011 18.9 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 KPI82859.1 - 0.0062 16.2 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KPI82859.1 - 0.07 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PUCC PF03209.15 KPI82859.1 - 0.076 12.0 5.4 0.13 11.3 5.4 1.2 1 0 0 1 1 1 0 PUCC protein DUF1772 PF08592.11 KPI82859.1 - 0.091 13.1 0.3 0.24 11.7 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) LRR_4 PF12799.7 KPI82860.1 - 1.3e-36 124.0 0.0 3.1e-05 24.2 0.0 8.4 7 1 1 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82860.1 - 1.2e-13 50.6 0.4 0.64 9.8 0.0 7.2 4 3 3 7 7 7 7 Leucine rich repeat LRR_6 PF13516.6 KPI82860.1 - 3.4e-12 45.4 1.8 0.87 9.8 0.0 8.3 8 0 0 8 8 8 5 Leucine Rich repeat LRR_1 PF00560.33 KPI82860.1 - 6.5e-05 22.9 12.0 26 5.9 0.0 10.0 10 2 0 10 10 10 1 Leucine Rich Repeat Peptidase_M3 PF01432.20 KPI82861.1 - 5.4e-125 418.2 0.1 6.7e-125 417.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M3 Vps62 PF06101.11 KPI82861.1 - 0.1 10.9 0.1 0.39 9.0 0.0 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 62 DUF2464 PF10240.9 KPI82862.1 - 6.4 6.3 8.3 7.4 6.1 0.8 2.5 2 0 0 2 2 2 0 Multivesicular body subunit 12 CoaE PF01121.20 KPI82863.1 - 1.9e-37 128.6 0.0 3.4e-37 127.8 0.0 1.3 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 KPI82863.1 - 0.0016 19.0 0.0 0.0074 16.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 KPI82863.1 - 0.03 14.4 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase AAA_33 PF13671.6 KPI82863.1 - 0.088 13.0 0.0 0.42 10.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain tRNA-synt_2c PF01411.19 KPI82864.1 - 2.1e-192 640.5 0.0 3.2e-192 639.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KPI82864.1 - 7.9e-12 45.1 0.0 1.7e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 KPI82864.1 - 9.6e-07 29.3 1.9 9.6e-07 29.3 1.9 2.1 2 0 0 2 2 2 1 DHHA1 domain YjbE PF11106.8 KPI82864.1 - 7.6 6.8 10.3 0.061 13.5 1.2 2.2 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE FliMN_C PF01052.20 KPI82865.1 - 0.068 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Type III flagellar switch regulator (C-ring) FliN C-term ETX_MTX2 PF03318.13 KPI82865.1 - 0.078 12.7 0.2 0.14 11.9 0.2 1.4 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 PPL5 PF18168.1 KPI82867.1 - 2.8e-153 509.9 0.0 4e-153 509.4 0.0 1.2 1 0 0 1 1 1 1 Prim-pol family 5 PriCT_2 PF08707.11 KPI82867.1 - 1.1e-11 45.0 0.2 2.8e-11 43.6 0.2 1.7 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) Aminotran_1_2 PF00155.21 KPI82868.1 - 4.8e-05 22.7 0.0 5.4e-05 22.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Exo_endo_phos PF03372.23 KPI82869.1 - 6.3e-09 35.7 0.4 1.2e-08 34.8 0.0 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 KPI82869.1 - 2.5e-08 33.9 0.0 5.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain DnaJ PF00226.31 KPI82870.1 - 2.1e-25 88.6 0.4 3.8e-25 87.8 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 KPI82870.1 - 7e-20 71.6 0.0 1.1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KPI82870.1 - 4.5e-07 30.1 15.0 4.5e-07 30.1 15.0 1.7 2 0 0 2 2 2 1 DnaJ central domain GRP PF07172.11 KPI82870.1 - 0.79 10.5 9.8 2 9.2 9.8 1.6 1 0 0 1 1 1 0 Glycine rich protein family TF_Zn_Ribbon PF08271.12 KPI82870.1 - 1.5 8.4 4.7 9.9 5.8 0.0 3.2 3 0 0 3 3 3 0 TFIIB zinc-binding Anti-TRAP PF15777.5 KPI82870.1 - 4.4 7.4 13.2 0.086 12.8 2.6 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Nucleoside_tran PF01733.18 KPI82871.1 - 6e-17 62.0 8.4 6.7e-17 61.8 8.4 1.0 1 0 0 1 1 1 1 Nucleoside transporter Herpes_LMP1 PF05297.11 KPI82871.1 - 0.056 12.6 0.4 0.074 12.3 0.4 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF3042 PF11240.8 KPI82871.1 - 0.13 12.3 0.6 0.22 11.6 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Pkinase PF00069.25 KPI82872.1 - 2e-41 142.1 0.0 2.9e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82872.1 - 7.1e-28 97.6 0.0 1e-27 97.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI82872.1 - 5.4e-07 28.7 0.0 1e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KPI82872.1 - 1.8e-05 24.3 0.0 2.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI82872.1 - 0.0066 16.4 0.1 0.19 11.6 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family LcrG PF07216.12 KPI82873.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 LcrG protein ABC_ATPase PF09818.9 KPI82874.1 - 6.7e-163 542.6 0.0 8.5e-163 542.3 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 KPI82874.1 - 0.005 17.4 0.0 0.0079 16.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain WD40 PF00400.32 KPI82875.1 - 1.4e-42 142.8 24.0 6.9e-08 33.0 1.4 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI82875.1 - 4.6e-13 49.3 0.9 0.0038 17.5 0.1 4.8 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI82875.1 - 1.4e-08 33.9 3.5 0.042 12.5 0.0 4.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 eIF2A PF08662.11 KPI82875.1 - 2.4e-06 27.6 0.0 0.089 12.7 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KPI82875.1 - 0.00025 20.1 1.9 0.023 13.7 0.5 3.2 2 2 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KPI82875.1 - 0.0013 18.6 0.0 6.3 6.9 0.0 4.6 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 KPI82875.1 - 0.0026 17.1 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 WD40-like domain Coatomer_WDAD PF04053.14 KPI82875.1 - 0.055 12.5 0.0 0.22 10.5 0.0 1.8 1 1 0 2 2 2 0 Coatomer WD associated region HPS3_N PF14761.6 KPI82875.1 - 0.11 12.1 0.0 8.6 5.8 0.0 2.8 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 DUF179 PF02622.15 KPI82876.1 - 6.6e-06 26.2 0.0 1.5e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 APG12 PF04110.13 KPI82877.1 - 0.067 13.6 0.0 1.1 9.7 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 Chorion_S16 PF05836.12 KPI82877.1 - 0.088 13.0 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Chorion protein S16 2OG-FeII_Oxy_2 PF13532.6 KPI82878.1 - 1.5e-05 25.2 0.0 2.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SOG2 PF10428.9 KPI82879.1 - 4 6.5 10.5 5.4 6.1 10.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Peptidase_C2 PF00648.21 KPI82880.1 - 4.6e-57 193.3 0.0 6.5e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI82880.1 - 8.8e-33 112.8 0.1 2e-32 111.6 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) CtsR_C PF17727.1 KPI82881.1 - 0.044 13.9 0.8 0.22 11.7 0.0 2.3 2 1 1 3 3 3 0 CtsR C-terminal dimerization domain Pept_tRNA_hydro PF01195.19 KPI82881.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase RRM_1 PF00076.22 KPI82882.1 - 1.8e-09 37.3 0.0 2.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KPI82882.1 - 0.00051 20.0 0.0 0.00094 19.2 0.0 1.5 1 1 0 1 1 1 1 RNA binding motif RRM_occluded PF16842.5 KPI82882.1 - 0.082 12.8 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Mpv17_PMP22 PF04117.12 KPI82883.1 - 1.1e-08 35.1 0.6 2.4e-08 34.1 0.6 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family Mlo PF03094.15 KPI82883.1 - 0.48 8.7 1.8 0.38 9.1 0.5 1.4 2 0 0 2 2 2 0 Mlo family WD40 PF00400.32 KPI82884.1 - 1.5e-22 79.4 4.9 0.00017 22.3 0.0 7.1 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI82884.1 - 5.6e-09 36.2 0.0 0.46 10.8 0.0 5.2 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain CSTF1_dimer PF16699.5 KPI82884.1 - 0.0013 18.5 0.0 0.0069 16.1 0.0 2.2 2 0 0 2 2 2 1 Cleavage stimulation factor subunit 1, dimerisation domain Cytochrom_D1 PF02239.16 KPI82884.1 - 0.015 13.9 0.3 0.21 10.1 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 KPI82884.1 - 0.13 11.2 0.2 18 4.2 0.0 3.3 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Rad9 PF04139.13 KPI82885.1 - 6.6e-09 35.6 0.0 8.6e-06 25.4 0.0 2.2 2 0 0 2 2 2 2 Rad9 Rad1 PF02144.16 KPI82885.1 - 0.0023 17.0 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 ThiF PF00899.21 KPI82886.1 - 2.5e-48 164.6 0.0 4.1e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 ThiF family PglD_N PF17836.1 KPI82886.1 - 0.0013 19.3 0.2 0.0038 17.8 0.0 1.9 2 0 0 2 2 2 1 PglD N-terminal domain UDPG_MGDP_dh_N PF03721.14 KPI82886.1 - 0.0084 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 KPI82886.1 - 0.01 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 KPI82886.1 - 0.029 14.0 0.2 0.075 12.7 0.2 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 KPI82886.1 - 0.095 13.0 0.0 0.095 13.0 0.0 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Evr1_Alr PF04777.13 KPI82887.1 - 6.6e-23 81.1 0.9 2.4e-22 79.3 0.3 2.2 2 0 0 2 2 2 1 Erv1 / Alr family Get5_C PF18514.1 KPI82887.1 - 0.12 12.1 0.1 0.33 10.7 0.1 1.7 1 0 0 1 1 1 0 Get5 C-terminal domain Ribosomal_S3_C PF00189.20 KPI82888.1 - 2.3e-19 69.7 2.0 2.3e-19 69.7 2.0 2.0 2 1 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 KPI82888.1 - 1.2e-07 31.5 0.2 3.3e-07 30.0 0.2 1.7 2 0 0 2 2 2 1 KH domain XylR_N PF06505.11 KPI82888.1 - 0.22 11.3 1.3 0.59 9.9 0.5 2.1 1 1 1 2 2 2 0 Activator of aromatic catabolism LRR_4 PF12799.7 KPI82889.1 - 8.2e-14 51.5 18.3 0.045 14.2 0.2 6.8 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82889.1 - 6.7e-06 25.8 15.7 0.75 9.6 0.0 6.5 4 2 3 7 7 7 5 Leucine rich repeat LRR_5 PF13306.6 KPI82889.1 - 0.023 14.7 0.5 2.7 8.0 0.1 3.1 2 2 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) F-box PF00646.33 KPI82889.1 - 0.16 11.9 2.2 0.24 11.3 0.1 2.4 2 0 0 2 2 2 0 F-box domain Glyco_hydro_47 PF01532.20 KPI82890.1 - 4.3e-18 65.5 0.0 5.4e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PUF PF00806.19 KPI82891.1 - 3.1e-16 58.0 0.0 1.7e-06 27.4 0.0 3.4 3 0 0 3 3 3 3 Pumilio-family RNA binding repeat DUF229 PF02995.17 KPI82892.1 - 7.9e-07 28.1 0.2 9.3e-07 27.8 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) 2-Hacid_dh_C PF02826.19 KPI82894.1 - 1.6e-52 177.5 0.0 2.5e-52 176.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KPI82894.1 - 9.2e-34 116.0 0.1 1.1e-33 115.7 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 KPI82894.1 - 0.0025 18.3 0.0 0.0083 16.6 0.0 1.8 2 0 0 2 2 2 1 XdhC Rossmann domain NAD_binding_2 PF03446.15 KPI82894.1 - 0.0053 16.9 0.4 0.014 15.6 0.2 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 KPI82894.1 - 0.081 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Aminotran_5 PF00266.19 KPI82895.1 - 6.9e-20 71.3 0.0 8.5e-20 71.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V PhageMin_Tail PF10145.9 KPI82895.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Phage-related minor tail protein Y_phosphatase3 PF13350.6 KPI82896.1 - 2.3e-06 27.8 0.5 4.4e-06 26.8 0.4 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KPI82896.1 - 0.00056 19.7 0.0 0.00094 19.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI82896.1 - 0.0031 17.1 0.0 0.0045 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KPI82896.1 - 0.0088 16.2 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 KPI82896.1 - 0.015 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) BT1 PF03092.16 KPI82897.1 - 1.3e-204 680.3 15.1 1.5e-204 680.1 15.1 1.0 1 0 0 1 1 1 1 BT1 family BT1 PF03092.16 KPI82898.1 - 4.3e-234 777.6 9.9 5.4e-234 777.3 9.9 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.16 KPI82898.1 - 0.0029 16.6 39.4 0.27 10.1 10.7 4.3 3 1 1 4 4 4 3 Major Facilitator Superfamily vATP-synt_AC39 PF01992.16 KPI82900.1 - 2.8e-84 283.5 0.2 3.2e-84 283.3 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit LRR_4 PF12799.7 KPI82901.1 - 7.2e-13 48.5 10.4 3e-05 24.3 0.1 5.8 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82901.1 - 1.2e-08 34.6 13.9 0.0037 17.0 0.4 5.6 5 1 0 6 6 6 4 Leucine rich repeat LRR_6 PF13516.6 KPI82901.1 - 0.041 14.0 23.2 0.13 12.4 0.1 6.6 8 0 0 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.33 KPI82901.1 - 0.095 13.3 11.2 6.5 7.7 0.1 5.2 6 0 0 6 6 6 0 Leucine Rich Repeat PA26 PF04636.13 KPI82901.1 - 3.1 6.6 4.5 12 4.7 0.0 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF898 PF05987.13 KPI82902.1 - 0.04 13.0 0.0 0.05 12.6 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) AP-5_subunit_s1 PF15001.6 KPI82902.1 - 0.066 13.2 0.0 0.083 12.9 0.0 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 DUF4834 PF16118.5 KPI82902.1 - 0.068 14.1 0.0 0.1 13.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) SDF PF00375.18 KPI82902.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family Thioredoxin_8 PF13905.6 KPI82903.1 - 1.7e-25 89.2 0.1 2.4e-25 88.7 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 KPI82903.1 - 9.2e-10 38.4 0.0 4.2e-08 33.1 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Redoxin PF08534.10 KPI82903.1 - 5.7e-08 32.6 0.0 7.8e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KPI82903.1 - 1.1e-06 28.6 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 KPI82903.1 - 1.4e-05 25.5 0.0 2.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KPI82903.1 - 0.00053 20.1 0.1 0.0011 19.1 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 KPI82903.1 - 0.0024 17.7 0.0 0.0042 16.9 0.0 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 KPI82903.1 - 0.031 14.1 0.0 0.078 12.7 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin Hex_IIIa PF02455.16 KPI82903.1 - 0.091 11.5 0.1 0.15 10.9 0.1 1.3 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Glutaredoxin PF00462.24 KPI82903.1 - 0.094 12.9 0.2 1 9.6 0.2 2.2 1 1 0 1 1 1 0 Glutaredoxin Thioredoxin_4 PF13462.6 KPI82903.1 - 0.2 11.8 0.4 0.49 10.5 0.3 1.6 1 1 1 2 2 2 0 Thioredoxin VSP PF03302.13 KPI82905.1 - 0.24 10.2 1.1 0.29 9.9 0.1 1.5 2 0 0 2 2 2 0 Giardia variant-specific surface protein PEPCK_ATP PF01293.20 KPI82906.1 - 0.0077 15.0 0.0 0.032 12.9 0.0 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate carboxykinase Pkinase PF00069.25 KPI82907.1 - 3.4e-43 147.9 0.0 4.2e-33 114.8 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82907.1 - 7.1e-27 94.3 0.0 7.6e-23 81.1 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI82907.1 - 1e-07 31.1 0.6 2.1e-06 26.8 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KPI82907.1 - 0.0049 16.2 0.0 0.68 9.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 KPI82907.1 - 0.0079 16.1 0.1 0.048 13.6 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family TPR_10 PF13374.6 KPI82907.1 - 0.05 13.5 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Kdo PF06293.14 KPI82907.1 - 0.14 11.5 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EphA2_TM PF14575.6 KPI82908.1 - 0.00035 21.4 0.9 0.0011 19.8 0.9 2.0 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Orthoreo_P10 PF07204.11 KPI82908.1 - 0.00064 19.6 1.6 0.0089 16.0 0.1 2.8 3 0 0 3 3 3 1 Orthoreovirus membrane fusion protein p10 Shisa PF13908.6 KPI82908.1 - 0.0051 17.1 2.3 0.0051 17.1 2.3 2.0 2 1 0 2 2 2 1 Wnt and FGF inhibitory regulator SpoIIIAH PF12685.7 KPI82908.1 - 0.0054 16.6 2.7 0.0084 16.0 2.7 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein Miga PF10265.9 KPI82908.1 - 0.0065 15.5 2.3 0.011 14.8 2.3 1.2 1 0 0 1 1 1 1 Mitoguardin PRIMA1 PF16101.5 KPI82908.1 - 0.0067 16.5 0.1 0.015 15.3 0.1 1.7 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 ASFV_J13L PF05568.11 KPI82908.1 - 0.011 15.6 1.0 0.023 14.5 0.7 1.7 1 1 0 1 1 1 0 African swine fever virus J13L protein Syndecan PF01034.20 KPI82908.1 - 0.014 15.3 0.2 0.035 14.0 0.2 1.6 1 0 0 1 1 1 0 Syndecan domain MAP17 PF15807.5 KPI82908.1 - 0.025 14.8 3.6 0.11 12.8 3.6 2.0 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FAM163 PF15069.6 KPI82908.1 - 0.038 14.4 0.4 0.098 13.1 0.1 1.9 2 0 0 2 2 2 0 FAM163 family DUF1129 PF06570.11 KPI82908.1 - 0.042 13.3 0.1 0.042 13.3 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Zip PF02535.22 KPI82908.1 - 0.043 13.0 0.1 0.072 12.3 0.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DAP10 PF07213.11 KPI82908.1 - 0.056 13.4 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 DAP10 membrane protein CCSMST1 PF15013.6 KPI82908.1 - 0.094 12.9 0.3 0.33 11.1 0.3 1.9 1 0 0 1 1 1 0 CCSMST1 family DAG1 PF05454.11 KPI82908.1 - 0.094 12.1 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) SIT PF15330.6 KPI82908.1 - 0.095 13.2 0.3 0.23 11.9 0.3 1.7 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT ECSCR PF15820.5 KPI82908.1 - 0.097 12.5 5.4 0.047 13.5 2.8 1.8 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator Cadherin_C_2 PF16492.5 KPI82908.1 - 0.2 12.4 2.4 0.73 10.6 2.4 2.0 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Collectrin PF16959.5 KPI82908.1 - 0.27 11.0 3.2 0.52 10.1 3.2 1.4 1 0 0 1 1 1 0 Renal amino acid transporter Phage_holin_3_6 PF07332.11 KPI82908.1 - 0.35 10.9 0.0 0.35 10.9 0.0 2.2 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Chordopox_A13L PF05961.11 KPI82908.1 - 0.52 10.6 2.1 3.5 7.9 1.0 2.6 2 0 0 2 2 2 0 Chordopoxvirus A13L protein 7TMR-DISM_7TM PF07695.11 KPI82908.1 - 0.89 9.4 5.1 3.9 7.3 0.2 2.2 2 0 0 2 2 2 0 7TM diverse intracellular signalling DUF4231 PF14015.6 KPI82908.1 - 1.5 9.3 6.2 7.3 7.1 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4834 PF16118.5 KPI82908.1 - 2.8 9.0 7.2 23 6.0 7.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 KPI82908.1 - 3.6 7.3 6.9 0.86 9.3 0.3 2.1 1 1 1 2 2 2 0 FAM176 family DUF1218 PF06749.12 KPI82908.1 - 4.2 8.0 9.6 4.3 7.9 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1218) ANAPC10 PF03256.16 KPI82909.1 - 1.6e-48 164.8 0.0 8.8e-43 146.1 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex, subunit 10 (APC10) Shisa PF13908.6 KPI82910.1 - 0.011 16.0 0.1 0.017 15.3 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMIE PF16038.5 KPI82910.1 - 0.033 14.0 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 TMIE protein Orthoreo_P10 PF07204.11 KPI82910.1 - 0.073 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 KPI82910.1 - 0.14 13.1 0.0 0.21 12.5 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UDPG_MGDP_dh_N PF03721.14 KPI82910.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF4941 PF16299.5 KPI82910.1 - 0.21 10.9 0.0 0.38 10.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4941) FGFR3_TM PF18123.1 KPI82910.1 - 4.5 6.9 9.2 11 5.7 9.2 1.6 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain FlaC_arch PF05377.11 KPI82911.1 - 0.012 16.0 0.9 0.36 11.2 0.0 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fmp27_WPPW PF10359.9 KPI82911.1 - 0.02 13.8 0.3 0.71 8.6 0.0 2.3 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain AKNA PF12443.8 KPI82911.1 - 0.32 11.7 6.1 1.2 9.9 0.1 3.9 3 1 1 4 4 4 0 AT-hook-containing transcription factor Jnk-SapK_ap_N PF09744.9 KPI82911.1 - 1.5 9.1 27.7 0.36 11.0 11.8 2.8 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 KPI82911.1 - 2.2 8.7 23.7 3 8.3 8.6 3.0 2 1 1 3 3 3 0 Fez1 Sec34 PF04136.15 KPI82911.1 - 2.9 7.7 8.3 12 5.7 0.2 3.4 3 0 0 3 3 3 0 Sec34-like family YabA PF06156.13 KPI82911.1 - 3.1 8.5 13.4 8.9 7.0 0.3 3.7 2 1 1 3 3 3 0 Initiation control protein YabA zf-RING_9 PF13901.6 KPI82912.1 - 8.3e-09 35.7 9.2 0.00076 19.5 0.0 5.3 3 2 2 5 5 5 3 Putative zinc-RING and/or ribbon FA_hydroxylase PF04116.13 KPI82913.1 - 3.2e-14 53.4 11.1 3.2e-14 53.4 11.1 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.28 KPI82913.1 - 5.8e-14 52.0 0.1 1.2e-13 51.0 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NPL PF17800.1 KPI82914.1 - 5.6e-16 59.0 0.0 9.2e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Nucleoplasmin-like domain ThiF PF00899.21 KPI82919.1 - 3.6e-10 39.6 1.1 7.8e-10 38.5 1.1 1.7 1 1 0 1 1 1 1 ThiF family DNA_ligase_ZBD PF03119.16 KPI82919.1 - 0.086 12.9 0.3 0.26 11.3 0.3 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain DUF1328 PF07043.13 KPI82919.1 - 0.11 12.8 1.8 0.27 11.5 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1328) Sacchrp_dh_NADP PF03435.18 KPI82921.1 - 1.3e-19 70.8 0.0 2.2e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 KPI82921.1 - 0.00031 20.7 0.0 0.0043 17.0 0.0 2.2 1 1 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 KPI82921.1 - 0.004 17.6 0.0 0.013 16.0 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KPI82921.1 - 0.0076 15.3 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KPI82921.1 - 0.02 14.4 0.0 0.039 13.4 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAT PF04768.13 KPI82922.1 - 0.066 12.9 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase AAA PF00004.29 KPI82923.1 - 1.4e-39 135.5 0.0 3e-39 134.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI82923.1 - 5.3e-11 42.1 0.0 2.1e-10 40.2 0.0 2.1 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 KPI82923.1 - 6.5e-10 38.9 0.4 2.1e-09 37.2 0.2 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 KPI82923.1 - 1.3e-05 25.0 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI82923.1 - 2.3e-05 24.8 0.0 0.0025 18.2 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KPI82923.1 - 0.00048 20.2 0.0 0.0018 18.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KPI82923.1 - 0.0012 18.3 0.1 0.0023 17.4 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KPI82923.1 - 0.0016 18.7 0.1 0.039 14.2 0.1 2.3 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 KPI82923.1 - 0.0032 16.8 0.0 1.2 8.4 0.0 2.5 1 1 1 2 2 2 2 KaiC AAA_24 PF13479.6 KPI82923.1 - 0.0036 17.1 0.0 0.0071 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KPI82923.1 - 0.0054 16.8 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI82923.1 - 0.0061 16.7 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 KPI82923.1 - 0.0084 16.2 0.0 0.025 14.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 KPI82923.1 - 0.0087 15.3 0.0 0.017 14.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KPI82923.1 - 0.01 15.6 0.0 0.036 13.8 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 KPI82923.1 - 0.013 16.1 0.3 0.033 14.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 KPI82923.1 - 0.013 15.1 0.2 0.32 10.5 0.1 2.6 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 KPI82923.1 - 0.023 14.2 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 KPI82923.1 - 0.026 14.9 0.0 0.058 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 KPI82923.1 - 0.048 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 NACHT domain PhoH PF02562.16 KPI82923.1 - 0.073 12.5 0.1 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Parvo_NS1 PF01057.17 KPI82923.1 - 0.092 11.8 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 KPI82923.1 - 0.11 12.9 0.6 0.81 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KPI82923.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KPI82923.1 - 0.14 12.4 0.0 0.4 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KPI82923.1 - 0.14 11.8 0.0 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain TLD PF07534.16 KPI82924.1 - 2.5e-16 60.1 0.0 6.6e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 TLD Peptidase_C97 PF05903.14 KPI82925.1 - 4.1e-28 98.1 0.0 7.6e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 KPI82925.1 - 0.011 16.1 0.4 0.033 14.5 0.0 2.0 2 0 0 2 2 2 0 Lecithin retinol acyltransferase Kinesin PF00225.23 KPI82926.1 - 8.3e-90 301.1 0.2 1.3e-89 300.5 0.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI82926.1 - 7.3e-16 58.4 0.0 1.7e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding FRP PF18032.1 KPI82926.1 - 0.055 14.1 0.4 0.13 12.9 0.4 1.6 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein PolyA_pol PF01743.20 KPI82927.1 - 0.048 14.1 0.1 0.1 13.0 0.0 1.7 1 1 0 1 1 1 0 Poly A polymerase head domain SCO1-SenC PF02630.14 KPI82929.1 - 3.9e-45 153.0 0.0 8.6e-45 151.9 0.0 1.6 2 0 0 2 2 2 1 SCO1/SenC Thioredoxin_8 PF13905.6 KPI82929.1 - 0.0032 17.8 0.0 0.0076 16.6 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KPI82929.1 - 0.013 15.4 0.1 0.051 13.5 0.0 1.9 1 1 1 2 2 2 0 AhpC/TSA family SARAF PF06682.12 KPI82930.1 - 2.9 7.5 5.8 3.9 7.0 5.8 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis UAA PF08449.11 KPI82932.1 - 7.3e-51 173.2 4.9 8.8e-33 113.8 0.0 2.0 2 0 0 2 2 2 2 UAA transporter family CRT-like PF08627.10 KPI82932.1 - 0.0037 16.3 0.1 0.0079 15.2 0.0 1.5 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Kinesin PF00225.23 KPI82933.1 - 3.7e-46 157.6 0.3 7.6e-46 156.6 0.3 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI82933.1 - 9e-15 54.9 0.0 3e-14 53.2 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KPI82933.1 - 0.036 14.5 0.0 0.036 14.5 0.0 4.0 2 1 1 3 3 3 0 AAA ATPase domain AAA_24 PF13479.6 KPI82933.1 - 0.073 12.8 0.0 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KPI82933.1 - 0.11 12.6 0.3 4.1 7.5 0.0 3.0 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_7 PF12775.7 KPI82933.1 - 0.17 11.4 0.0 0.42 10.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KPI82933.1 - 0.19 12.0 0.0 0.19 12.0 0.0 3.1 2 1 1 3 3 3 0 AAA domain DUF87 PF01935.17 KPI82933.1 - 0.38 10.8 0.0 0.38 10.8 0.0 3.6 2 2 3 5 5 5 0 Helicase HerA, central domain SBP_bac_11 PF13531.6 KPI82933.1 - 0.83 9.4 6.1 0.13 11.9 0.4 2.5 3 0 0 3 3 3 0 Bacterial extracellular solute-binding protein EF-hand_7 PF13499.6 KPI82935.1 - 1.8e-32 111.6 11.8 1.5e-06 28.5 0.0 5.7 5 0 0 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.32 KPI82935.1 - 6.2e-27 91.1 16.4 0.0023 17.4 0.1 8.7 8 0 0 8 8 8 7 EF hand EF-hand_6 PF13405.6 KPI82935.1 - 9.2e-25 84.4 16.4 0.002 17.9 0.1 8.5 8 0 0 8 8 8 6 EF-hand domain EF-hand_5 PF13202.6 KPI82935.1 - 1.4e-16 59.2 17.3 0.00092 18.6 0.0 7.3 8 0 0 8 8 8 4 EF hand EF-hand_8 PF13833.6 KPI82935.1 - 1.2e-15 57.0 13.4 0.00067 19.5 0.1 8.4 8 1 0 8 8 8 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KPI82935.1 - 1.3e-07 31.9 0.2 0.26 11.6 0.0 4.8 5 0 0 5 5 5 2 Secreted protein acidic and rich in cysteine Ca binding region FGAR-AT_linker PF18072.1 KPI82935.1 - 0.11 13.1 0.2 34 5.1 0.0 3.6 3 0 0 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain EF-hand_4 PF12763.7 KPI82935.1 - 1.4 8.9 4.2 7.7 6.5 0.0 4.1 4 1 2 6 6 6 0 Cytoskeletal-regulatory complex EF hand zf_CCCH_4 PF18345.1 KPI82936.1 - 0.0023 17.9 1.7 0.0045 17.0 1.7 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 KPI82936.1 - 0.024 14.6 0.4 0.046 13.7 0.4 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 KPI82936.1 - 4.1 7.7 8.1 2.6 8.3 0.0 3.1 2 1 1 3 3 3 0 Zinc-finger containing family MMADHC PF10229.9 KPI82936.1 - 4.5 6.9 18.1 7.2 6.3 16.9 1.9 1 1 1 2 2 2 0 Methylmalonic aciduria and homocystinuria type D protein Adhesin_E PF16747.5 KPI82937.1 - 0.13 12.3 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Surface-adhesin protein E DAGK_acc PF00609.19 KPI82938.1 - 1.4e-21 77.5 0.0 4.4e-20 72.6 0.0 2.5 1 1 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KPI82938.1 - 2.5e-07 30.4 0.1 2.6e-06 27.1 0.0 2.7 2 1 0 2 2 2 1 Diacylglycerol kinase catalytic domain T3SchapCesA PF11439.8 KPI82940.1 - 0.01 16.0 0.3 0.067 13.3 0.2 2.2 2 0 0 2 2 2 1 Type III secretion system filament chaperone CesA AIP3 PF03915.13 KPI82940.1 - 0.012 14.7 3.8 0.025 13.7 3.1 1.8 1 1 0 1 1 1 0 Actin interacting protein 3 DUF3150 PF11348.8 KPI82940.1 - 0.02 14.1 1.1 0.3 10.3 1.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3150) ING PF12998.7 KPI82940.1 - 0.031 14.9 6.6 0.54 10.9 0.2 2.9 3 0 0 3 3 2 0 Inhibitor of growth proteins N-terminal histone-binding PhoU PF01895.19 KPI82940.1 - 0.059 13.8 0.3 0.059 13.8 0.3 3.6 3 1 1 4 4 4 0 PhoU domain DUF725 PF05267.12 KPI82940.1 - 0.088 12.8 2.1 0.72 9.8 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF725) Mt_ATP-synt_D PF05873.12 KPI82940.1 - 0.11 12.3 2.4 0.16 11.8 0.1 2.4 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) DUF4407 PF14362.6 KPI82940.1 - 0.15 11.4 10.7 14 4.9 10.6 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) YkyA PF10368.9 KPI82940.1 - 0.16 11.6 10.0 1.2 8.7 0.5 2.9 2 1 1 3 3 3 0 Putative cell-wall binding lipoprotein DUF948 PF06103.11 KPI82940.1 - 0.23 11.8 6.0 8 6.8 0.1 4.2 3 2 2 5 5 4 0 Bacterial protein of unknown function (DUF948) EzrA PF06160.12 KPI82940.1 - 0.25 9.5 11.9 0.22 9.7 2.8 3.0 3 1 0 3 3 3 0 Septation ring formation regulator, EzrA Syntaxin-6_N PF09177.11 KPI82940.1 - 0.33 11.5 10.4 2.2 8.9 2.0 3.5 3 1 0 3 3 3 0 Syntaxin 6, N-terminal LXG PF04740.12 KPI82940.1 - 0.35 10.5 6.0 12 5.5 5.2 2.6 1 1 1 2 2 2 0 LXG domain of WXG superfamily Pox_A_type_inc PF04508.12 KPI82940.1 - 0.37 10.7 0.1 0.37 10.7 0.1 4.1 5 0 0 5 5 3 0 Viral A-type inclusion protein repeat PRKG1_interact PF15898.5 KPI82940.1 - 0.5 11.3 12.4 3.3 8.7 2.4 3.6 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Fib_alpha PF08702.10 KPI82940.1 - 0.57 10.4 4.3 3.2 7.9 0.2 3.5 2 1 3 5 5 4 0 Fibrinogen alpha/beta chain family Streptin-Immun PF11083.8 KPI82940.1 - 0.58 10.6 8.4 8.7 6.8 0.2 3.9 4 0 0 4 4 4 0 Lantibiotic streptin immunity protein DUF5082 PF16888.5 KPI82940.1 - 0.61 10.4 8.8 2.1 8.6 0.1 4.0 4 1 1 5 5 4 0 Domain of unknown function (DUF5082) Seryl_tRNA_N PF02403.22 KPI82940.1 - 0.62 10.3 11.8 1.2 9.4 0.1 3.8 3 1 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.12 KPI82940.1 - 0.65 10.5 3.6 6.8 7.2 0.0 3.7 4 0 0 4 4 3 0 Nucleopolyhedrovirus P10 protein FAM184 PF15665.5 KPI82940.1 - 1.2 8.8 23.6 0.62 9.8 8.1 3.1 2 1 0 3 3 3 0 Family with sequence similarity 184, A and B DUF1640 PF07798.11 KPI82940.1 - 1.5 8.8 11.6 7.2 6.6 0.1 3.5 3 1 0 4 4 3 0 Protein of unknown function (DUF1640) BshC PF10079.9 KPI82940.1 - 1.6 7.4 5.6 6.6 5.3 0.6 2.1 2 0 0 2 2 2 0 Bacillithiol biosynthesis BshC TMPIT PF07851.13 KPI82940.1 - 2.1 7.5 5.1 0.96 8.6 1.3 2.2 1 1 0 2 2 2 0 TMPIT-like protein HU-CCDC81_bac_2 PF18175.1 KPI82940.1 - 2.5 8.1 0.0 2.5 8.1 0.0 4.2 5 0 0 5 5 5 0 CCDC81-like prokaryotic HU domain 2 SH3BP5 PF05276.14 KPI82940.1 - 4 7.2 10.3 15 5.3 0.2 3.4 1 1 1 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) APG6_N PF17675.1 KPI82940.1 - 5.3 7.6 23.4 0.69 10.4 6.8 3.3 3 0 0 3 3 3 0 Apg6 coiled-coil region Suppressor_APC PF11414.8 KPI82940.1 - 5.8 7.1 15.1 8.1 6.6 4.4 3.1 2 2 1 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein DUF1664 PF07889.12 KPI82940.1 - 6.1 6.9 10.4 6.4 6.8 0.4 3.7 2 1 1 4 4 3 0 Protein of unknown function (DUF1664) Cytochrom_B562 PF07361.11 KPI82940.1 - 6.7 7.4 10.5 6.1 7.6 0.6 3.7 3 1 1 4 4 4 0 Cytochrome b562 DUF5344 PF17279.2 KPI82940.1 - 7.5 7.2 7.9 34 5.1 0.1 3.8 2 2 2 4 4 4 0 Family of unknown function (DUF5344) Atg8 PF02991.16 KPI82942.1 - 5.3e-12 45.8 0.0 2.9e-11 43.5 0.0 1.9 2 0 0 2 2 2 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KPI82942.1 - 1.7e-05 25.1 0.0 2.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Pyridoxal_deC PF00282.19 KPI82943.1 - 9.8e-95 317.4 0.0 1.2e-94 317.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain AAA PF00004.29 KPI82946.1 - 2e-51 173.9 0.0 1.5e-40 138.7 0.0 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI82946.1 - 8.8e-12 44.6 2.5 2.3e-09 36.9 1.3 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 KPI82946.1 - 3.2e-10 40.4 0.0 6.4e-06 26.5 0.0 3.0 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 KPI82946.1 - 3.9e-09 37.1 6.7 0.016 15.6 5.3 4.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 KPI82946.1 - 0.00027 21.1 0.0 0.57 10.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 KPI82946.1 - 0.00033 20.5 0.0 0.001 18.8 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KPI82946.1 - 0.00045 20.2 0.6 0.068 13.2 0.0 3.1 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 KPI82946.1 - 0.00054 19.9 0.0 0.31 10.9 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 KPI82946.1 - 0.00059 19.4 0.0 0.93 9.0 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region RNA_helicase PF00910.22 KPI82946.1 - 0.00073 19.9 0.0 0.47 10.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 KPI82946.1 - 0.00086 19.5 0.0 0.056 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 KPI82946.1 - 0.0018 18.1 0.1 0.33 10.7 0.0 2.9 3 0 0 3 3 3 1 IstB-like ATP binding protein TIP49 PF06068.13 KPI82946.1 - 0.0026 17.0 0.1 0.0089 15.3 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_25 PF13481.6 KPI82946.1 - 0.0032 17.1 1.2 3.7 7.1 0.0 4.0 3 1 0 3 3 3 1 AAA domain TniB PF05621.11 KPI82946.1 - 0.0033 16.9 0.0 0.052 13.0 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein ABC_tran PF00005.27 KPI82946.1 - 0.0041 17.6 0.0 2.8 8.4 0.0 2.5 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 KPI82946.1 - 0.0058 15.9 0.3 4.9 6.4 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin Mg_chelatase PF01078.21 KPI82946.1 - 0.013 14.9 0.2 0.059 12.7 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 KPI82946.1 - 0.023 14.6 0.0 0.076 12.9 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain Sigma54_activat PF00158.26 KPI82946.1 - 0.039 13.7 0.0 9.8 5.8 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 KPI82946.1 - 0.048 13.4 0.0 6.8 6.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 KPI82946.1 - 0.059 12.5 0.0 3.2 6.8 0.0 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 KPI82946.1 - 0.08 12.8 0.0 13 5.7 0.0 2.8 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea ATPase PF06745.13 KPI82946.1 - 0.1 11.9 0.0 7.9 5.7 0.0 2.6 2 0 0 2 2 2 0 KaiC Vps4_C PF09336.10 KPI82946.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.8 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain DNA_ligase_OB_2 PF14743.6 KPI82950.1 - 7.2e-17 61.2 0.1 1.5e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 DNA ligase OB-like domain DUF4379 PF14311.6 KPI82950.1 - 1.6e-14 54.0 1.8 4.5e-14 52.6 1.8 1.8 1 0 0 1 1 1 1 Probable Zinc-ribbon domain DNA_ligase_A_M PF01068.21 KPI82950.1 - 8.4e-13 48.4 0.0 1.7e-05 24.6 0.0 2.6 3 0 0 3 3 3 2 ATP dependent DNA ligase domain mRNA_cap_enzyme PF01331.19 KPI82950.1 - 0.013 15.4 0.0 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain Zn-ribbon_8 PF09723.10 KPI82950.1 - 0.014 15.5 1.3 0.039 14.1 1.3 1.7 1 0 0 1 1 1 0 Zinc ribbon domain ADK_lid PF05191.14 KPI82950.1 - 0.25 11.3 1.8 0.63 10.1 1.8 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid CC PF04942.14 KPI82950.1 - 0.35 11.1 1.8 33 4.8 0.4 3.0 2 0 0 2 2 2 0 CC domain Zn_ribbon_SprT PF17283.2 KPI82950.1 - 1.1 9.2 4.8 4.9 7.1 4.8 2.1 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zinc_ribbon_4 PF13717.6 KPI82950.1 - 4.7 7.2 5.5 27 4.8 0.7 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 KPI82950.1 - 4.8 7.0 6.3 7.2 6.4 1.1 2.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain PhnA_Zn_Ribbon PF08274.12 KPI82950.1 - 6.4 6.8 7.1 2.1 8.4 1.0 2.6 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DNA_ligase_A_M PF01068.21 KPI82951.1 - 1.1e-21 77.4 0.0 4.3e-21 75.5 0.0 1.9 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.6 KPI82951.1 - 1.2e-17 63.6 0.2 3.3e-17 62.3 0.1 1.8 2 0 0 2 2 2 1 DNA ligase OB-like domain mRNA_cap_enzyme PF01331.19 KPI82951.1 - 2.7e-05 24.1 0.0 0.082 12.7 0.2 2.9 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain DUF4379 PF14311.6 KPI82951.1 - 0.00027 21.2 6.8 0.00066 20.0 6.8 1.8 1 0 0 1 1 1 1 Probable Zinc-ribbon domain DUF2072 PF09845.9 KPI82951.1 - 0.015 15.5 0.5 0.45 10.8 0.0 2.2 2 0 0 2 2 2 0 Zn-ribbon containing protein Dehalogenase PF13486.6 KPI82951.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Reductive dehalogenase subunit Zn-ribbon_8 PF09723.10 KPI82951.1 - 0.35 11.0 2.7 1.2 9.3 2.7 2.0 1 0 0 1 1 1 0 Zinc ribbon domain Hydrolase_4 PF12146.8 KPI82952.1 - 6.7e-10 38.6 0.0 4.7e-08 32.6 0.0 2.3 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI82952.1 - 5.8e-07 29.4 0.1 3.6e-05 23.5 0.1 2.3 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 KPI82952.1 - 1.8e-06 27.8 0.0 5e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 KPI82952.1 - 0.0013 19.4 0.0 0.0021 18.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 KPI82952.1 - 0.015 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Putative esterase BAAT_C PF08840.11 KPI82952.1 - 0.027 14.4 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 KPI82952.1 - 0.028 13.9 0.0 0.14 11.6 0.0 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family PhoPQ_related PF10142.9 KPI82952.1 - 0.036 12.7 0.0 0.043 12.5 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein DLH PF01738.18 KPI82952.1 - 0.046 13.3 0.0 9.2 5.7 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family AXE1 PF05448.12 KPI82952.1 - 0.15 10.7 0.0 9 4.9 0.0 2.3 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) PAP2 PF01569.21 KPI82953.1 - 1.2e-19 70.5 1.6 2.5e-19 69.4 1.6 1.5 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 KPI82953.1 - 0.46 10.6 3.6 2.7 8.1 0.1 2.9 3 0 0 3 3 3 0 Divergent PAP2 family CPP1-like PF11833.8 KPI82953.1 - 9.3 5.8 6.4 3.5 7.2 1.5 2.4 3 0 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like WD40 PF00400.32 KPI82954.1 - 5.5e-29 99.8 15.4 1.2e-08 35.5 0.6 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI82954.1 - 3.9e-16 59.1 0.2 0.00017 21.8 0.0 5.4 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI82954.1 - 0.0033 16.4 0.0 0.041 12.9 0.0 2.4 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Scytalone_dh PF02982.14 KPI82954.1 - 0.14 12.0 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Scytalone dehydratase DAGK_cat PF00781.24 KPI82955.1 - 6.5e-14 51.6 0.0 1.3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Evr1_Alr PF04777.13 KPI82956.1 - 6.7e-10 39.3 0.1 4.7e-09 36.6 0.1 2.4 1 1 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 KPI82956.1 - 1.4e-08 34.7 0.0 2.6e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KPI82956.1 - 0.0021 17.5 0.1 0.021 14.2 0.0 2.1 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family TraF PF13728.6 KPI82956.1 - 0.035 13.9 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Amidohydro_1 PF01979.20 KPI82957.1 - 3.7e-09 36.4 0.4 4.8e-09 36.0 0.4 1.2 1 0 0 1 1 1 1 Amidohydrolase family TatD_DNase PF01026.21 KPI82957.1 - 0.00012 21.5 4.1 0.00018 21.0 1.9 1.9 1 1 1 2 2 2 1 TatD related DNase CCG PF02754.16 KPI82957.1 - 0.051 13.8 1.8 1 9.6 0.4 2.4 2 0 0 2 2 2 0 Cysteine-rich domain Usp PF00582.26 KPI82957.1 - 0.15 12.6 2.2 0.34 11.4 0.8 2.2 2 1 1 3 3 3 0 Universal stress protein family CPSase_L_D2 PF02786.17 KPI82958.1 - 3.4e-101 337.1 0.2 3.2e-77 258.8 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 KPI82958.1 - 5.3e-47 158.8 0.0 1.4e-46 157.5 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 KPI82958.1 - 3.3e-41 141.2 0.0 7.4e-41 140.0 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 KPI82958.1 - 7e-29 100.7 0.0 1.4e-28 99.7 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 KPI82958.1 - 1.3e-21 76.9 0.1 3.6e-11 42.9 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KPI82958.1 - 2.4e-11 43.6 0.2 0.0002 21.0 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus Arginosuc_synth PF00764.19 KPI82958.1 - 1.3e-10 41.1 0.0 3.5e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Arginosuccinate synthase ATPgrasp_Ter PF15632.6 KPI82958.1 - 5.1e-10 39.2 0.0 4.9e-05 23.1 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.22 KPI82958.1 - 1.7e-07 31.3 0.0 7.4e-07 29.3 0.0 2.2 1 0 0 1 1 1 1 MGS-like domain Peptidase_C26 PF07722.13 KPI82958.1 - 7.1e-07 29.2 0.5 3.3e-05 23.8 0.5 2.6 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 KPI82958.1 - 7.2e-06 26.1 0.2 0.00063 19.8 0.0 2.6 2 0 0 2 2 2 1 ATP-grasp domain DJ-1_PfpI PF01965.24 KPI82958.1 - 0.0012 18.7 0.1 0.0075 16.1 0.0 2.4 2 0 0 2 2 2 1 DJ-1/PfpI family GSH-S_ATP PF02955.16 KPI82958.1 - 0.013 14.9 0.0 0.032 13.6 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain TrkA_N PF02254.18 KPI82958.1 - 0.046 14.0 0.0 0.21 11.9 0.0 2.1 2 0 0 2 2 1 0 TrkA-N domain DotD PF16816.5 KPI82958.1 - 0.13 12.2 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 DotD protein Ank_2 PF12796.7 KPI82959.1 - 9e-13 48.6 2.0 0.00024 21.6 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI82959.1 - 1.1e-12 48.1 5.0 0.0006 20.3 0.1 5.2 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI82959.1 - 8.5e-08 32.3 10.3 0.0014 18.9 0.3 4.7 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI82959.1 - 3.5e-05 23.8 7.4 0.12 13.0 0.1 5.7 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 KPI82959.1 - 0.00013 22.3 12.1 0.3 11.6 0.2 6.5 6 0 0 6 6 6 2 Ankyrin repeat Ribosomal_L20 PF00453.18 KPI82959.1 - 1.3 9.2 4.5 0.81 9.8 1.2 2.4 2 0 0 2 2 2 0 Ribosomal protein L20 SPAN-X PF07458.12 KPI82960.1 - 0.00035 21.0 0.4 0.00035 21.0 0.4 3.5 4 1 0 4 4 4 1 Sperm protein associated with nucleus, mapped to X chromosome Pkinase PF00069.25 KPI82961.1 - 2.4e-44 151.7 0.0 3.3e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI82961.1 - 7.9e-36 123.7 0.0 9.8e-36 123.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI82961.1 - 0.0037 16.1 0.0 0.0077 15.1 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KPI82961.1 - 0.026 14.5 0.1 0.069 13.1 0.1 1.6 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KPI82961.1 - 0.059 12.3 0.1 0.11 11.4 0.1 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 KPI82961.1 - 0.13 11.8 0.0 0.58 9.7 0.0 1.9 1 1 0 1 1 1 0 Choline/ethanolamine kinase AAA PF00004.29 KPI82962.1 - 6.6e-40 136.6 0.0 1.8e-39 135.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 KPI82962.1 - 1.6e-24 85.7 0.2 6.7e-24 83.7 0.2 2.1 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 KPI82962.1 - 1.4e-17 63.5 1.5 1.4e-17 63.5 1.5 2.1 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 KPI82962.1 - 1.9e-11 43.6 0.2 7.9e-10 38.4 0.0 3.1 3 0 0 3 3 3 1 AAA+ lid domain AAA_2 PF07724.14 KPI82962.1 - 5e-06 26.7 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KPI82962.1 - 8.4e-06 26.3 0.2 0.00039 20.8 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 KPI82962.1 - 2.7e-05 24.5 0.1 0.0025 18.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KPI82962.1 - 0.00018 21.5 0.0 0.00085 19.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 KPI82962.1 - 0.00042 19.6 0.0 0.0012 18.1 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KPI82962.1 - 0.00048 19.9 0.0 0.0013 18.4 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 KPI82962.1 - 0.00059 19.6 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KPI82962.1 - 0.0012 19.0 0.0 0.0031 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 KPI82962.1 - 0.0012 18.1 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 KPI82962.1 - 0.0017 18.1 0.0 0.0041 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain USP8_dimer PF08969.11 KPI82962.1 - 0.0017 18.5 3.2 0.0043 17.2 3.2 1.7 1 0 0 1 1 1 1 USP8 dimerisation domain AAA_14 PF13173.6 KPI82962.1 - 0.0018 18.3 0.0 0.0066 16.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI82962.1 - 0.0027 18.2 0.1 0.0085 16.6 0.0 2.1 2 1 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 KPI82962.1 - 0.0036 17.7 0.0 0.0098 16.3 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 KPI82962.1 - 0.0068 16.0 0.4 0.76 9.3 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 KPI82962.1 - 0.018 15.5 0.1 0.086 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 KPI82962.1 - 0.026 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 KPI82962.1 - 0.031 14.2 3.1 2.5 7.9 0.0 2.9 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 KPI82962.1 - 0.035 13.5 0.1 0.097 12.0 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PPV_E1_C PF00519.17 KPI82962.1 - 0.061 12.2 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase Parvo_NS1 PF01057.17 KPI82962.1 - 0.062 12.4 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.12 KPI82962.1 - 0.083 12.7 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 KPI82962.1 - 0.091 12.7 0.0 0.64 9.9 0.0 2.1 1 1 0 2 2 2 0 NACHT domain Ntox28 PF15605.6 KPI82962.1 - 0.096 12.9 0.2 2.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial toxin 28 Ribosomal_60s PF00428.19 KPI82962.1 - 0.12 12.9 3.4 0.37 11.4 3.4 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein PhoH PF02562.16 KPI82962.1 - 0.13 11.7 0.1 0.29 10.6 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 KPI82962.1 - 0.17 11.4 0.0 0.43 10.1 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 KPI82962.1 - 0.18 11.5 0.0 0.47 10.1 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF2262 PF10020.9 KPI82962.1 - 0.55 10.6 3.5 4.2 7.7 1.5 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2262) Dus PF01207.17 KPI82963.1 - 4.9e-49 167.1 0.0 7.2e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) dCMP_cyt_deam_1 PF00383.23 KPI82964.1 - 5.5e-12 45.5 5.1 8.9e-12 44.8 5.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 KPI82964.1 - 7.4e-11 42.4 4.8 1e-07 32.2 4.1 2.4 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 KPI82964.1 - 0.0015 18.2 5.0 0.0066 16.1 5.0 2.1 1 1 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases Sec20 PF03908.13 KPI82966.1 - 7.4e-09 35.4 2.5 9.9e-09 35.0 0.2 2.3 3 0 0 3 3 2 1 Sec20 V-SNARE_C PF12352.8 KPI82966.1 - 5.6e-06 26.5 1.7 1.5e-05 25.1 1.7 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus SNARE PF05739.19 KPI82966.1 - 0.00064 19.7 1.1 0.00064 19.7 1.1 1.9 2 0 0 2 2 1 1 SNARE domain V-SNARE PF05008.15 KPI82966.1 - 0.0012 19.1 8.2 0.0079 16.6 1.7 2.7 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Not3 PF04065.15 KPI82966.1 - 0.0084 15.6 2.3 0.026 14.0 0.2 2.1 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component DUF2721 PF11026.8 KPI82966.1 - 0.023 14.6 9.2 0.037 13.9 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) Prominin PF05478.11 KPI82966.1 - 0.024 12.6 2.3 0.15 10.0 0.1 2.0 2 0 0 2 2 2 0 Prominin BORCS7 PF16088.5 KPI82966.1 - 0.03 14.6 2.8 0.28 11.4 0.3 2.6 2 1 1 3 3 3 0 BLOC-1-related complex sub-unit 7 YlqD PF11068.8 KPI82966.1 - 0.061 13.7 1.0 0.061 13.7 1.0 3.1 2 2 1 3 3 3 0 YlqD protein DASH_Duo1 PF08651.10 KPI82966.1 - 0.095 12.5 2.6 0.39 10.5 0.1 3.0 3 1 0 3 3 3 0 DASH complex subunit Duo1 DUF2207 PF09972.9 KPI82966.1 - 0.11 11.2 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Csm1_N PF18504.1 KPI82966.1 - 0.28 11.6 6.4 5.7 7.4 0.3 3.5 3 1 0 3 3 3 0 Csm1 N-terminal domain Baculo_PEP_C PF04513.12 KPI82966.1 - 0.42 10.7 5.9 7.3 6.6 0.2 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus EMP24_GP25L PF01105.24 KPI82966.1 - 0.48 10.4 2.8 4.3 7.2 0.2 2.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4407 PF14362.6 KPI82966.1 - 0.78 9.0 12.7 1.7 7.9 6.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4618 PF15397.6 KPI82966.1 - 0.86 9.0 7.7 0.4 10.1 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) zf-C4H2 PF10146.9 KPI82966.1 - 0.99 9.7 5.0 2.5 8.3 0.5 2.4 2 1 0 2 2 2 0 Zinc finger-containing protein Snapin_Pallidin PF14712.6 KPI82966.1 - 1 9.8 8.8 37 4.8 1.8 3.5 2 2 1 3 3 3 0 Snapin/Pallidin XhlA PF10779.9 KPI82966.1 - 1.3 9.3 3.4 5.9 7.2 0.4 3.0 2 1 2 4 4 4 0 Haemolysin XhlA DUF2203 PF09969.9 KPI82966.1 - 1.5 9.6 8.0 23 5.7 3.5 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4200 PF13863.6 KPI82966.1 - 2.2 8.7 9.7 0.14 12.6 0.7 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) GrpE PF01025.19 KPI82966.1 - 2.8 7.6 7.6 1.7 8.3 0.2 2.9 2 1 0 2 2 2 0 GrpE DUF16 PF01519.16 KPI82966.1 - 3.1 8.3 5.0 1.8 9.1 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 DivIC PF04977.15 KPI82966.1 - 5.1 7.0 11.3 4.4 7.1 0.4 4.0 3 1 1 4 4 4 0 Septum formation initiator HIP1_clath_bdg PF16515.5 KPI82966.1 - 7.5 7.2 11.6 0.46 11.1 1.1 2.9 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FbpA PF05833.11 KPI82967.1 - 1.2e-28 100.1 9.9 2.5e-20 72.7 0.2 2.8 3 0 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 KPI82967.1 - 9.7e-23 80.9 0.0 2.5e-22 79.6 0.0 1.8 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-C PF11923.8 KPI82967.1 - 8.7e-10 38.5 1.1 2.9e-09 36.8 0.1 2.5 2 0 0 2 2 2 1 NFACT protein C-terminal domain FAM199X PF15814.5 KPI82967.1 - 1.7 7.6 12.2 0.078 12.0 2.6 2.7 3 0 0 3 3 3 0 Protein family FAM199X SepSecS PF05889.13 KPI82968.1 - 2.2e-91 306.5 0.0 3.5e-51 174.1 0.0 3.6 3 1 0 3 3 3 3 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 KPI82968.1 - 0.00012 21.4 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DUF2721 PF11026.8 KPI82970.1 - 0.00026 20.9 0.2 0.00026 20.9 0.2 2.9 3 1 1 4 4 4 1 Protein of unknown function (DUF2721) Spermine_synth PF01564.17 KPI82971.1 - 8e-52 175.4 0.0 1.2e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KPI82971.1 - 7.7e-16 57.7 0.0 1.6e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KPI82971.1 - 0.0002 22.0 0.0 0.00034 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI82971.1 - 0.022 15.5 0.1 0.2 12.4 0.1 2.5 4 0 0 4 4 4 0 Methyltransferase domain CRM1_repeat_2 PF18784.1 KPI82971.1 - 0.031 13.9 0.0 0.07 12.8 0.0 1.6 1 0 0 1 1 1 0 CRM1 / Exportin repeat 2 DENN PF02141.21 KPI82972.1 - 3.2e-09 37.0 0.7 8.6e-09 35.6 0.2 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain Y_phosphatase2 PF03162.13 KPI82973.1 - 6.1e-51 172.3 0.0 8.7e-51 171.8 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KPI82973.1 - 1.1e-08 35.3 0.0 1.8e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KPI82973.1 - 0.022 14.4 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.20 KPI82973.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain CLASP_N PF12348.8 KPI82976.1 - 5.6e-12 45.7 2.8 4.6e-07 29.6 0.2 3.6 4 0 0 4 4 4 2 CLASP N terminal NUC173 PF08161.12 KPI82976.1 - 0.016 14.9 0.8 0.44 10.2 0.1 3.3 2 1 1 3 3 3 0 NUC173 domain Cnd1 PF12717.7 KPI82976.1 - 0.019 15.0 6.7 25 4.9 0.0 5.2 3 2 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Gaa1 PF04114.14 KPI82977.1 - 3.3e-08 33.0 4.9 2.1e-07 30.3 4.7 1.9 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component Ribosomal_L37ae PF01780.19 KPI82978.1 - 2.3e-36 123.7 4.3 2.6e-36 123.6 4.3 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family C1_1 PF00130.22 KPI82978.1 - 0.0027 17.6 2.0 0.0039 17.1 2.0 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_13 PF17977.1 KPI82978.1 - 0.047 13.8 1.0 0.066 13.4 1.0 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 KPI82978.1 - 0.11 12.5 3.3 0.19 11.8 3.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain NOB1_Zn_bind PF08772.11 KPI82978.1 - 0.19 11.9 3.4 0.62 10.3 0.4 2.3 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-HIT PF04438.16 KPI82978.1 - 0.23 11.4 2.4 0.32 10.9 0.5 1.9 2 0 0 2 2 2 0 HIT zinc finger Proteasome PF00227.26 KPI82979.1 - 1.7e-58 197.2 0.0 2.1e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI82979.1 - 9.7e-14 50.7 0.0 4e-13 48.8 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Pex14_N PF04695.13 KPI82980.1 - 4.2e-23 82.7 1.2 4.2e-23 82.7 1.2 4.5 3 2 2 5 5 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Rootletin PF15035.6 KPI82980.1 - 1.5e-06 28.4 2.7 2.5e-06 27.7 2.7 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion ERM PF00769.19 KPI82980.1 - 0.011 15.6 9.4 0.016 15.1 9.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ATG16 PF08614.11 KPI82980.1 - 0.011 16.0 4.4 0.033 14.4 4.4 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) HOOK PF05622.12 KPI82980.1 - 0.017 13.3 3.5 0.023 12.9 3.5 1.0 1 0 0 1 1 1 0 HOOK protein DUF812 PF05667.11 KPI82980.1 - 0.017 14.0 0.4 0.028 13.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4407 PF14362.6 KPI82980.1 - 0.022 14.1 1.9 0.035 13.4 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 KPI82980.1 - 0.028 14.9 6.0 0.045 14.3 6.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF2408 PF10303.9 KPI82980.1 - 0.029 14.9 0.9 0.043 14.4 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) GIT_CC PF16559.5 KPI82980.1 - 0.039 13.8 1.9 0.046 13.6 0.5 1.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3450 PF11932.8 KPI82980.1 - 0.052 12.8 4.3 0.077 12.3 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Uso1_p115_C PF04871.13 KPI82980.1 - 0.062 13.7 9.6 0.11 12.9 9.6 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region HBM PF16591.5 KPI82980.1 - 0.072 12.5 3.0 0.11 11.9 3.0 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain FapA PF03961.13 KPI82980.1 - 0.1 11.2 1.2 0.14 10.7 1.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ada3 PF10198.9 KPI82980.1 - 0.12 12.5 2.6 0.56 10.3 1.3 2.1 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 CENP-H PF05837.12 KPI82980.1 - 0.27 11.6 7.0 0.5 10.8 7.0 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) PRKG1_interact PF15898.5 KPI82980.1 - 0.29 12.1 4.3 0.59 11.1 4.3 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain SlyX PF04102.12 KPI82980.1 - 0.31 11.7 3.4 0.39 11.4 0.8 2.3 1 1 1 2 2 2 0 SlyX Atg14 PF10186.9 KPI82980.1 - 0.32 10.0 2.5 0.45 9.5 2.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GAS PF13851.6 KPI82980.1 - 0.51 9.7 8.1 0.81 9.0 8.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 KPI82980.1 - 0.58 9.0 6.0 0.9 8.4 6.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 KPI82980.1 - 0.7 10.2 4.8 1.2 9.5 4.8 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2968 PF11180.8 KPI82980.1 - 1 8.9 6.4 1.8 8.2 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) WXG100 PF06013.12 KPI82980.1 - 1.5 9.1 4.9 2 8.7 1.1 2.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG DUF5082 PF16888.5 KPI82980.1 - 1.5 9.1 5.4 5.4 7.3 5.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Csm1_N PF18504.1 KPI82980.1 - 3 8.3 7.7 3.5 8.0 6.4 1.7 1 1 1 2 2 2 0 Csm1 N-terminal domain DivIC PF04977.15 KPI82980.1 - 3.3 7.5 10.4 0.69 9.7 5.6 2.2 2 1 1 3 3 2 0 Septum formation initiator LPP PF04728.13 KPI82980.1 - 3.8 8.0 6.6 2.6 8.5 1.3 2.5 1 1 1 2 2 2 0 Lipoprotein leucine-zipper DUF4616 PF15394.6 KPI82980.1 - 6.9 5.5 11.6 1 8.3 7.9 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4616) BolA PF01722.18 KPI82982.1 - 1.8e-17 63.4 0.1 5.5e-17 61.8 0.1 1.7 1 1 0 1 1 1 1 BolA-like protein Ank_2 PF12796.7 KPI82983.1 - 3.1e-10 40.5 0.2 6.1e-09 36.4 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI82983.1 - 3e-07 30.9 0.5 0.0013 19.2 0.1 3.5 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI82983.1 - 5.7e-07 29.7 4.4 0.00041 20.6 0.4 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 KPI82983.1 - 1.4e-06 28.0 8.5 3.1e-06 26.9 8.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_3 PF13606.6 KPI82983.1 - 2.8e-05 24.2 1.0 0.0028 18.0 0.1 3.4 2 1 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 KPI82983.1 - 0.0079 16.6 0.4 0.064 13.7 0.2 2.6 3 0 0 3 3 3 1 Ankyrin repeat zf-C3HC4 PF00097.25 KPI82983.1 - 0.012 15.4 9.9 0.024 14.5 9.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI82983.1 - 0.021 14.7 10.0 0.043 13.7 10.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KPI82983.1 - 1.1 9.2 11.7 2.6 8.0 11.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps51 PF08700.11 KPI82984.1 - 3.2e-08 33.5 0.0 8.4e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Vps51/Vps67 FabA PF07977.13 KPI82985.1 - 0.099 12.3 0.1 0.26 10.9 0.0 1.7 2 0 0 2 2 2 0 FabA-like domain LRR_4 PF12799.7 KPI82988.1 - 7.1e-32 108.9 2.2 2.4e-05 24.6 0.0 6.6 6 1 1 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI82988.1 - 1.8e-12 46.8 0.6 0.16 11.8 0.0 6.3 6 1 0 6 6 6 5 Leucine rich repeat LRR_6 PF13516.6 KPI82988.1 - 0.018 15.1 12.6 9.6 6.6 0.1 7.7 9 0 0 9 9 9 0 Leucine Rich repeat DUF4072 PF13284.6 KPI82988.1 - 0.024 15.0 2.1 24 5.5 0.1 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF4072) AA_kinase PF00696.28 KPI82990.1 - 1.9e-41 142.3 0.0 2.3e-41 142.0 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family Glucosamine_iso PF01182.20 KPI82991.1 - 1.6e-50 172.1 0.0 1.9e-50 171.8 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase CPBP PF02517.16 KPI82992.1 - 4.4e-16 59.0 1.7 1.2e-15 57.6 1.6 1.8 1 1 0 1 1 1 1 CPBP intramembrane metalloprotease PSP1 PF04468.12 KPI82993.1 - 3.4e-17 62.5 1.2 5e-17 62.0 1.2 1.2 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Leptin PF02024.15 KPI82993.1 - 0.07 12.9 0.2 0.1 12.4 0.2 1.2 1 0 0 1 1 1 0 Leptin PAP2_C PF14360.6 KPI82994.1 - 9.3e-18 64.5 9.9 9.3e-18 64.5 9.9 2.6 4 0 0 4 4 4 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KPI82994.1 - 0.39 10.5 14.7 0.07 12.9 7.4 2.8 3 1 0 3 3 3 0 PAP2 superfamily TM_helix PF05552.12 KPI82994.1 - 2.3 8.3 5.9 1.5 8.8 3.5 1.9 2 0 0 2 2 2 0 Conserved TM helix Mucin PF01456.17 KPI82995.1 - 0.013 15.5 12.3 0.021 14.8 12.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Preseq_ALAS PF09029.10 KPI82995.1 - 0.046 14.2 1.3 0.064 13.7 1.1 1.4 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence UcrQ PF02939.16 KPI82997.1 - 0.047 13.6 1.4 2.8 7.9 0.1 2.5 2 0 0 2 2 2 0 UcrQ family zf-CCCH_4 PF18044.1 KPI82998.1 - 1.5e-07 31.1 3.3 2.2e-07 30.5 3.3 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI82998.1 - 2.9e-05 23.9 4.8 5.2e-05 23.1 4.8 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 KPI82998.1 - 8.3e-05 22.4 3.9 0.00017 21.4 3.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KPI82998.1 - 0.00025 21.4 3.1 0.00046 20.5 3.1 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KPI82998.1 - 0.005 17.5 2.4 0.0076 16.9 2.5 1.4 1 1 0 1 1 1 1 Torus domain FUSC_2 PF13515.6 KPI82999.1 - 6.3e-08 32.8 4.0 6.3e-08 32.8 4.0 2.5 2 0 0 2 2 2 1 Fusaric acid resistance protein-like CRAL_TRIO PF00650.20 KPI83000.1 - 9.1e-28 97.0 0.1 1.5e-27 96.3 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KPI83000.1 - 1.3e-05 25.3 0.2 3.3e-05 24.0 0.2 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF2497 PF10691.9 KPI83001.1 - 3.9e-06 27.2 2.8 1.2e-05 25.7 0.0 3.2 2 2 0 2 2 2 1 Protein of unknown function (DUF2497) Spc7 PF08317.11 KPI83001.1 - 0.0026 16.7 27.3 0.083 11.8 9.8 2.4 1 1 1 2 2 2 2 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 KPI83001.1 - 0.0032 17.5 10.2 0.025 14.6 0.4 3.4 2 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 KPI83001.1 - 0.008 16.4 17.9 0.2 11.8 3.6 2.9 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family LMP PF04778.12 KPI83001.1 - 0.043 13.7 2.2 4.3 7.2 0.2 2.6 2 0 0 2 2 2 0 LMP repeated region DUF4718 PF15842.5 KPI83001.1 - 0.07 12.9 3.9 0.29 10.9 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) Apolipoprotein PF01442.18 KPI83001.1 - 0.089 12.7 36.1 0.56 10.1 35.8 2.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain ACR_tran PF00873.19 KPI83001.1 - 0.12 10.0 6.1 0.17 9.5 6.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Filament PF00038.21 KPI83001.1 - 0.22 11.1 33.2 0.9 9.1 13.3 3.6 2 1 2 4 4 4 0 Intermediate filament protein GAS PF13851.6 KPI83001.1 - 0.29 10.5 27.1 0.051 12.9 14.3 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding GldM_N PF12081.8 KPI83001.1 - 0.33 11.0 5.9 0.45 10.6 0.4 3.1 3 1 0 3 3 3 0 GldM N-terminal domain DUF3584 PF12128.8 KPI83001.1 - 0.37 8.3 27.3 0.58 7.6 27.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF148 PF02520.17 KPI83001.1 - 0.39 10.8 12.0 4 7.6 0.9 4.2 2 1 2 4 4 4 0 Domain of unknown function DUF148 Prominin PF05478.11 KPI83001.1 - 0.51 8.2 12.0 0.9 7.4 12.0 1.3 1 0 0 1 1 1 0 Prominin FAP206 PF12018.8 KPI83001.1 - 0.63 9.5 9.9 1.7 8.1 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF1043 PF06295.12 KPI83001.1 - 1 9.4 11.7 2.4 8.2 3.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) FapA PF03961.13 KPI83001.1 - 1.4 7.5 11.8 0.25 9.9 4.2 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A SseC PF04888.12 KPI83001.1 - 2.2 7.8 7.9 0.23 11.0 1.9 2.1 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family ApoLp-III PF07464.11 KPI83001.1 - 3.1 7.9 15.0 8.7 6.4 8.7 2.7 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) LMBR1 PF04791.16 KPI83001.1 - 4.7 6.0 10.4 8.7 5.1 10.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein SesA PF17107.5 KPI83001.1 - 9.6 6.4 10.1 1.8 8.8 2.5 2.7 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PPR_2 PF13041.6 KPI83002.1 - 5.5e-15 55.3 5.2 0.00021 21.4 0.1 5.8 6 0 0 6 6 6 3 PPR repeat family PPR_long PF17177.4 KPI83002.1 - 4.9e-14 52.2 0.3 0.00026 20.4 0.0 3.6 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 KPI83002.1 - 2.8e-13 49.7 0.2 0.00019 21.4 0.0 4.5 3 1 2 5 5 5 3 Pentatricopeptide repeat domain PPR PF01535.20 KPI83002.1 - 1.2e-08 34.7 6.9 0.0012 19.0 0.4 5.6 6 0 0 6 6 6 3 PPR repeat PPR_1 PF12854.7 KPI83002.1 - 2.3e-07 30.4 0.1 0.15 11.8 0.0 5.0 5 0 0 5 5 5 2 PPR repeat Pkr1 PF08636.10 KPI83003.1 - 3.3e-06 27.1 9.1 3.9e-06 26.9 9.1 1.1 1 0 0 1 1 1 1 ER protein Pkr1 YfhO PF09586.10 KPI83003.1 - 0.026 12.8 0.0 0.026 12.8 0.0 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF983 PF06170.12 KPI83003.1 - 0.27 11.7 5.9 0.35 11.3 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF983) ANAPC4_WD40 PF12894.7 KPI83004.1 - 0.0034 17.6 0.0 0.015 15.6 0.0 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Plant_all_beta PF10532.9 KPI83004.1 - 0.12 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Plant specific N-all beta domain CHORD PF04968.12 KPI83006.1 - 1.1e-36 125.3 37.0 7.8e-19 68.2 15.4 2.2 2 0 0 2 2 2 2 CHORD CHCH PF06747.13 KPI83007.1 - 5e-05 23.3 3.2 7.9e-05 22.7 3.2 1.4 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 KPI83007.1 - 0.0017 18.3 1.3 0.0042 17.1 1.4 1.6 1 1 1 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 KPI83007.1 - 0.038 14.3 0.9 0.062 13.6 0.9 1.3 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 KPI83007.1 - 0.096 12.4 1.2 0.13 12.0 1.2 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 KPI83008.1 - 0.0024 18.0 0.8 0.0036 17.4 0.8 1.3 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 KPI83008.1 - 0.044 14.1 0.4 0.066 13.5 0.4 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Pkinase PF00069.25 KPI83009.1 - 6.5e-38 130.6 0.0 2e-09 37.2 0.0 6.0 6 0 0 6 6 6 5 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83009.1 - 3.1e-14 52.9 0.0 2.3e-08 33.7 0.0 4.2 4 0 0 4 4 4 3 Protein tyrosine kinase FHA PF00498.26 KPI83009.1 - 9.4e-12 45.1 0.9 3.9e-11 43.1 0.3 2.3 2 1 0 2 2 2 1 FHA domain InvH PF04741.12 KPI83009.1 - 0.026 14.5 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 InvH outer membrane lipoprotein zf-C3HC4_3 PF13920.6 KPI83010.1 - 1.2e-10 41.1 6.5 2.2e-10 40.2 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI83010.1 - 2.3e-08 33.8 6.9 4.2e-08 32.9 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI83010.1 - 4.9e-08 33.2 8.3 9.6e-08 32.2 8.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI83010.1 - 2.6e-05 24.0 8.5 5.9e-05 22.8 8.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI83010.1 - 4.3e-05 23.4 7.7 7.4e-05 22.6 7.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KPI83010.1 - 0.00025 21.0 4.9 0.00055 19.9 4.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KPI83010.1 - 0.00036 20.3 10.4 0.00089 19.1 10.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KPI83010.1 - 0.0012 18.9 7.1 0.0031 17.6 7.1 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KPI83010.1 - 0.0068 16.2 4.9 0.017 14.9 4.9 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Baculo_IE-1 PF05290.11 KPI83010.1 - 0.0088 16.0 2.7 0.019 15.0 2.7 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-ANAPC11 PF12861.7 KPI83010.1 - 0.16 12.1 5.8 0.47 10.5 5.6 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KPI83010.1 - 0.47 10.8 9.3 1.9 8.9 9.3 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KPI83010.1 - 0.82 9.5 9.2 1 9.2 7.1 2.3 2 0 0 2 2 2 0 RING-like zinc finger DZR PF12773.7 KPI83010.1 - 1.8 8.6 5.8 8.7 6.5 5.9 2.1 1 1 1 2 2 2 0 Double zinc ribbon C1_1 PF00130.22 KPI83010.1 - 2.4 8.1 7.3 0.47 10.4 3.4 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3565 PF12088.8 KPI83010.1 - 3.7 7.6 10.5 14 5.8 3.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3565) NDUF_B8 PF05821.11 KPI83013.1 - 0.055 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) FAD_binding_2 PF00890.24 KPI83014.1 - 2.4e-85 287.1 0.0 3.8e-85 286.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain ApbE PF02424.15 KPI83014.1 - 4.1e-48 164.2 0.0 8.1e-47 159.9 0.0 2.3 1 1 0 1 1 1 1 ApbE family NAD_binding_1 PF00175.21 KPI83014.1 - 1.7e-17 64.0 0.0 3.7e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DAO PF01266.24 KPI83014.1 - 7.1e-12 45.6 0.9 8.5e-11 42.0 1.8 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KPI83014.1 - 4e-10 39.6 2.5 8.9e-10 38.5 2.4 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KPI83014.1 - 1.4e-09 37.6 0.0 3.3e-09 36.4 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_6 PF00970.24 KPI83014.1 - 2.8e-08 34.0 0.0 5.9e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain GIDA PF01134.22 KPI83014.1 - 1.6e-07 30.8 5.1 1.6e-06 27.5 2.8 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 KPI83014.1 - 2.3e-07 30.9 0.6 1e-06 28.9 0.6 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 KPI83014.1 - 1.9e-05 24.1 1.0 4.3e-05 22.9 1.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KPI83014.1 - 1.9e-05 23.6 5.0 0.00058 18.7 3.8 2.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 KPI83014.1 - 0.0017 18.9 1.2 0.0052 17.3 1.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KPI83014.1 - 0.0026 17.1 2.3 0.12 11.6 2.8 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_6 PF08030.12 KPI83014.1 - 0.0068 16.5 0.0 0.18 11.9 0.0 2.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_3 PF01494.19 KPI83014.1 - 0.029 13.6 0.7 0.044 13.0 0.7 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 KPI83014.1 - 0.11 11.7 1.5 0.99 8.6 0.7 2.4 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 KPI83014.1 - 0.17 10.9 2.2 0.33 9.9 2.2 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Motile_Sperm PF00635.26 KPI83016.1 - 1.2e-05 25.1 0.3 0.0001 22.1 0.0 2.6 3 0 0 3 3 3 1 MSP (Major sperm protein) domain Hamartin PF04388.12 KPI83016.1 - 0.0029 16.3 5.6 0.0042 15.8 5.6 1.1 1 0 0 1 1 1 1 Hamartin protein DUF4588 PF15251.6 KPI83016.1 - 0.11 12.2 4.0 0.16 11.7 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) K1377 PF15352.6 KPI83016.1 - 1.6 6.9 5.9 2.1 6.5 5.9 1.1 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy Pkinase PF00069.25 KPI83017.1 - 3.8e-67 226.4 0.0 4.4e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83017.1 - 8.8e-31 107.1 0.0 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI83017.1 - 0.00035 20.6 0.8 0.029 14.3 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 KPI83017.1 - 0.00063 19.1 0.1 0.0011 18.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI83017.1 - 0.015 14.2 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KPI83017.1 - 0.031 13.1 0.0 0.037 12.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase LSM PF01423.22 KPI83018.1 - 0.00012 21.7 0.2 0.00056 19.5 0.0 2.1 2 1 0 2 2 2 1 LSM domain AMP-binding PF00501.28 KPI83020.1 - 4.5e-27 94.7 0.1 5.4e-27 94.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KPI83020.1 - 3.4e-17 63.2 0.1 5.5e-17 62.5 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain EF-hand_1 PF00036.32 KPI83021.1 - 2.4e-09 36.1 0.1 5.5e-05 22.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KPI83021.1 - 4.3e-08 33.5 0.3 1.3e-07 31.9 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI83021.1 - 7.7e-07 28.6 4.7 0.0023 17.7 0.1 3.5 4 1 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KPI83021.1 - 0.00011 21.5 0.2 0.17 11.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KPI83021.1 - 0.00014 21.6 0.1 0.022 14.6 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain pair SOG2 PF10428.9 KPI83021.1 - 0.038 13.2 10.7 0.058 12.6 10.7 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein XRN_N PF03159.18 KPI83022.1 - 3.2e-59 200.3 0.0 4.8e-59 199.7 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KPI83022.1 - 7.3e-06 25.2 16.7 0.00019 20.5 0.0 4.0 4 0 0 4 4 4 3 Xrn1 helical domain SKA2 PF16740.5 KPI83023.1 - 0.011 15.6 5.1 0.073 12.8 1.5 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 ERM PF00769.19 KPI83023.1 - 2 8.1 7.5 3.2 7.5 7.5 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ABC_membrane PF00664.23 KPI83024.1 - 1.8e-72 244.3 25.4 7.4e-39 134.0 15.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KPI83024.1 - 8.9e-21 74.8 0.0 2.3e-20 73.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI83024.1 - 4.3e-05 23.1 0.2 0.0088 15.5 0.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KPI83024.1 - 0.00019 21.4 0.0 0.0087 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KPI83024.1 - 0.00044 19.9 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KPI83024.1 - 0.0062 16.5 0.0 0.021 14.8 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KPI83024.1 - 0.01 16.3 0.2 0.062 13.7 0.0 2.1 1 1 0 2 2 2 0 AAA ATPase domain CAP_GLY PF01302.25 KPI83024.1 - 0.012 15.6 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 CAP-Gly domain FtsK_SpoIIIE PF01580.18 KPI83024.1 - 0.015 14.7 0.0 0.039 13.3 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 KPI83024.1 - 0.023 15.0 0.0 0.084 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KPI83024.1 - 0.027 15.0 0.9 0.04 14.4 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KPI83024.1 - 0.04 13.5 0.1 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 KPI83024.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Dynamin family T2SSE PF00437.20 KPI83024.1 - 0.095 11.7 0.0 0.23 10.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 KPI83024.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 KPI83024.1 - 0.15 12.2 0.1 0.57 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Yip1 PF04893.17 KPI83026.1 - 1.2e-15 57.7 17.1 1.7e-15 57.1 16.9 1.4 1 1 0 1 1 1 1 Yip1 domain DAG1 PF05454.11 KPI83029.1 - 0.006 16.0 0.0 0.0063 15.9 0.0 1.1 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) CesT PF05932.13 KPI83030.1 - 2.6e-10 40.4 0.0 7.7e-10 38.9 0.0 1.9 1 0 0 1 1 1 1 Tir chaperone protein (CesT) family PDZ_2 PF13180.6 KPI83030.1 - 3.7e-07 30.4 0.0 0.00011 22.4 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KPI83030.1 - 1.6e-06 27.8 0.1 4.9e-05 23.1 0.0 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_1 PF12812.7 KPI83030.1 - 0.086 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 PDZ-like domain ubiquitin PF00240.23 KPI83030.1 - 0.091 12.5 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin family Ax_dynein_light PF10211.9 KPI83032.1 - 4.9e-12 46.2 5.6 4.9e-12 46.2 5.6 1.9 2 0 0 2 2 2 1 Axonemal dynein light chain UQ_con PF00179.26 KPI83033.1 - 2.4e-45 153.6 0.0 2.7e-45 153.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KPI83033.1 - 0.0075 16.1 0.1 0.015 15.1 0.1 1.5 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 KPI83033.1 - 0.01 15.5 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B LRR_4 PF12799.7 KPI83035.1 - 0.0022 18.4 0.4 0.26 11.8 0.1 2.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83035.1 - 0.019 14.7 0.1 0.053 13.3 0.1 1.7 1 0 0 1 1 1 0 Leucine rich repeat LRR_4 PF12799.7 KPI83036.1 - 2.8e-27 94.3 18.7 1.6e-05 25.2 0.6 7.1 4 3 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI83036.1 - 2.1e-21 76.2 7.3 2.1e-09 37.1 0.1 3.5 2 1 2 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 KPI83036.1 - 1.2e-18 66.6 22.0 6.1e-07 29.1 2.3 6.1 3 2 4 7 7 7 6 Leucine rich repeat LRR_6 PF13516.6 KPI83036.1 - 3.8e-06 26.5 14.0 0.12 12.5 0.0 8.2 9 0 0 9 9 9 2 Leucine Rich repeat LRR_1 PF00560.33 KPI83036.1 - 0.0016 18.7 15.6 18 6.4 0.1 8.0 7 3 0 7 7 7 1 Leucine Rich Repeat Prefoldin_2 PF01920.20 KPI83037.1 - 1.3e-17 63.7 3.0 1.3e-17 63.7 3.0 2.6 1 1 2 3 3 3 1 Prefoldin subunit NPV_P10 PF05531.12 KPI83037.1 - 0.016 15.7 5.1 1.2 9.6 0.1 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein pP_pnuc_1 PF18165.1 KPI83037.1 - 0.029 14.2 1.4 0.045 13.6 1.4 1.3 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease PCRF PF03462.18 KPI83037.1 - 0.031 14.2 5.3 0.073 12.9 0.0 2.0 1 1 1 2 2 2 0 PCRF domain YkyA PF10368.9 KPI83037.1 - 0.043 13.5 7.7 0.16 11.6 6.4 2.1 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein DHR10 PF18595.1 KPI83037.1 - 0.084 12.9 0.5 0.084 12.9 0.5 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 KPI83037.1 - 0.086 13.2 4.9 11 6.4 0.5 3.3 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) FliD_C PF07195.12 KPI83037.1 - 0.11 11.9 4.0 0.13 11.6 4.1 1.3 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus kleA_kleC PF17383.2 KPI83037.1 - 0.11 12.8 2.3 0.14 12.5 1.2 1.6 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A DUF948 PF06103.11 KPI83037.1 - 0.18 12.1 1.5 6.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.11 KPI83037.1 - 0.24 9.3 4.1 0.14 10.1 2.4 1.4 1 1 0 1 1 1 0 Prominin Spc24 PF08286.11 KPI83037.1 - 1.3 9.3 8.9 7.7 6.8 3.9 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF724 PF05266.14 KPI83037.1 - 1.9 8.3 8.7 2 8.2 3.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) FlxA PF14282.6 KPI83037.1 - 2.4 8.2 21.5 0.41 10.7 0.6 2.4 2 0 0 2 2 2 0 FlxA-like protein CheB_methylest PF01339.17 KPI83038.1 - 0.087 12.5 0.1 0.48 10.1 0.0 2.2 2 0 0 2 2 2 0 CheB methylesterase AcylCoA_dehyd_C PF12186.8 KPI83038.1 - 0.55 10.4 5.2 6.7 6.9 0.9 3.2 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal bVLRF1 PF18826.1 KPI83040.1 - 1.5e-37 128.7 0.4 3.5e-37 127.5 0.0 1.9 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor acVLRF1 PF18859.1 KPI83040.1 - 6.4 7.1 9.1 0.19 12.0 0.4 2.7 3 0 0 3 3 3 0 Actinobacteria/chloroflexi VLRF1 release factor TF_Zn_Ribbon PF08271.12 KPI83041.1 - 0.34 10.5 2.2 0.38 10.3 0.8 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding MAD PF05557.13 KPI83042.1 - 0.0054 15.2 1.2 0.0076 14.7 1.2 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF1664 PF07889.12 KPI83042.1 - 0.0081 16.2 0.1 0.021 14.9 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) GAS PF13851.6 KPI83042.1 - 0.011 15.1 3.1 0.013 14.9 1.9 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.22 KPI83042.1 - 0.018 15.3 1.7 3.6 7.9 0.2 2.6 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Ada3 PF10198.9 KPI83042.1 - 0.031 14.4 1.6 0.083 13.0 1.3 1.9 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 Med9 PF07544.13 KPI83042.1 - 0.1 12.7 0.6 0.28 11.3 0.4 1.9 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 YabA PF06156.13 KPI83042.1 - 0.22 12.2 1.8 2.6 8.8 0.0 2.5 2 1 1 3 3 3 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 KPI83042.1 - 0.43 10.6 5.6 0.22 11.5 3.4 1.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 KPI83042.1 - 0.77 10.3 6.4 2.2 8.8 6.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region PRORP PF16953.5 KPI83043.1 - 6.4e-28 97.9 2.4 6.6e-21 74.9 0.3 2.6 2 1 0 2 2 2 2 Protein-only RNase P RNase_Zc3h12a PF11977.8 KPI83043.1 - 0.06 13.1 0.0 0.83 9.4 0.0 2.2 2 0 0 2 2 2 0 Zc3h12a-like Ribonuclease NYN domain Ras PF00071.22 KPI83045.1 - 1.9e-20 73.1 6.2 1.1e-17 64.1 0.1 2.9 3 1 0 3 3 3 2 Ras family Roc PF08477.13 KPI83045.1 - 1.5e-13 51.0 0.0 1.2e-07 31.9 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KPI83045.1 - 6e-08 32.4 0.1 1.2e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KPI83045.1 - 1.8e-06 27.5 0.0 7.5e-05 22.3 0.0 2.9 4 0 0 4 4 4 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI83045.1 - 2.9e-05 23.6 0.1 8.4e-05 22.0 0.1 1.8 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI83045.1 - 0.00013 22.1 0.0 0.00072 19.6 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KPI83045.1 - 0.035 14.2 1.2 0.24 11.4 0.0 2.9 3 1 1 4 4 4 0 Dynamin family G-alpha PF00503.20 KPI83045.1 - 0.083 12.0 0.0 0.8 8.8 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit FAM199X PF15814.5 KPI83045.1 - 0.1 11.7 1.6 0.29 10.1 0.0 2.5 3 0 0 3 3 3 0 Protein family FAM199X MTS PF05175.14 KPI83046.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain 60KD_IMP PF02096.20 KPI83047.1 - 7.3e-11 42.2 1.6 1.1e-10 41.6 1.6 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein GTP_EFTU PF00009.27 KPI83048.1 - 5.6e-41 140.2 0.0 1.1e-40 139.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KPI83048.1 - 5.1e-28 97.6 0.1 1.4e-27 96.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KPI83048.1 - 5.5e-05 23.5 0.3 0.00036 20.9 0.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KPI83048.1 - 0.0016 18.5 0.0 0.0085 16.2 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase 2_5_RNA_ligase2 PF13563.6 KPI83048.1 - 0.053 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily SPX PF03105.19 KPI83048.1 - 1.9 8.3 14.6 3 7.7 14.6 1.2 1 0 0 1 1 1 0 SPX domain CCDC53 PF10152.9 KPI83048.1 - 9.3 6.7 25.4 0.38 11.2 8.4 2.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Sec16_C PF12931.7 KPI83049.1 - 5.1e-07 29.6 0.0 4e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 KPI83049.1 - 1.5e-06 28.8 8.8 0.013 16.3 0.1 5.0 4 0 0 4 4 4 2 WD domain, G-beta repeat TPR_2 PF07719.17 KPI83049.1 - 2.6e-05 24.0 1.6 0.17 12.1 0.4 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83049.1 - 0.00038 20.7 2.3 0.023 15.0 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83049.1 - 0.0011 18.7 1.9 0.14 12.0 0.5 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83049.1 - 0.17 12.2 0.6 6 7.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat AIF_C PF14721.6 KPI83049.1 - 0.22 11.9 0.4 0.48 10.8 0.4 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM83 PF07894.12 KPI83049.1 - 0.34 10.4 1.6 0.56 9.7 1.6 1.2 1 0 0 1 1 1 0 FAM83 A-H TPR_7 PF13176.6 KPI83049.1 - 0.35 11.0 1.9 2.1 8.6 0.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Stealth_CR2 PF11380.8 KPI83050.1 - 5.1e-23 81.3 0.1 4.7e-18 65.3 0.0 2.5 2 0 0 2 2 2 2 Stealth protein CR2, conserved region 2 CH PF00307.31 KPI83051.1 - 0.0073 16.5 0.0 0.016 15.4 0.0 1.7 1 1 0 1 1 1 1 Calponin homology (CH) domain Pkinase PF00069.25 KPI83053.1 - 3.7e-41 141.2 0.0 6e-19 68.4 0.0 3.5 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83053.1 - 2e-24 86.3 0.0 1.2e-14 54.2 0.0 3.4 3 0 0 3 3 3 3 Protein tyrosine kinase APH PF01636.23 KPI83053.1 - 0.0024 17.9 0.0 0.0056 16.6 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI83053.1 - 0.1 11.9 0.0 0.36 10.2 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI83053.1 - 0.1 11.3 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase MKT1_C PF12246.8 KPI83054.1 - 1.3e-14 54.1 0.0 2.5e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 KPI83054.1 - 1.1e-11 44.9 0.0 2.2e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication Cyclin_C PF02984.19 KPI83055.1 - 0.056 13.5 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 Cyclin, C-terminal domain PCI PF01399.27 KPI83056.1 - 0.0037 17.7 0.6 0.02 15.4 0.6 2.1 1 1 0 1 1 1 1 PCI domain Phage_holin_3_6 PF07332.11 KPI83058.1 - 0.1 12.7 3.2 0.28 11.2 0.4 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Myb_DNA-bind_7 PF15963.5 KPI83060.1 - 1.3e-23 82.7 1.2 1.3e-23 82.7 1.2 1.6 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 KPI83060.1 - 0.00042 20.5 0.0 0.00079 19.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF1439 PF07273.12 KPI83061.1 - 0.15 11.9 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1439) LicD PF04991.13 KPI83062.1 - 3.4e-06 27.4 0.2 0.00012 22.3 0.2 2.1 1 1 1 2 2 2 2 LicD family Deltaretro_Tax PF05599.11 KPI83062.1 - 0.011 16.2 0.0 0.028 14.9 0.0 1.6 1 0 0 1 1 1 0 Deltaretrovirus Tax protein PDCD2_C PF04194.13 KPI83063.1 - 2e-23 83.3 0.1 2e-23 83.3 0.1 2.1 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain NUDIX PF00293.28 KPI83063.1 - 0.015 15.4 0.1 0.028 14.5 0.1 1.4 1 0 0 1 1 1 0 NUDIX domain Elf1 PF05129.13 KPI83063.1 - 0.025 14.6 0.3 0.094 12.8 0.1 2.0 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like TF_Zn_Ribbon PF08271.12 KPI83063.1 - 0.22 11.0 2.9 1.2 8.7 0.5 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 KPI83063.1 - 0.36 11.0 4.8 20 5.4 0.3 3.7 3 0 0 3 3 3 0 Zinc ribbon domain zf-RRN7 PF11781.8 KPI83063.1 - 0.44 10.3 5.1 2.3 8.0 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-ribbon_3 PF13248.6 KPI83063.1 - 0.85 9.1 7.2 6 6.4 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Ank_2 PF12796.7 KPI83064.1 - 1.4e-26 92.9 2.7 6.2e-11 42.7 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI83064.1 - 4.6e-20 71.7 0.1 6.5e-08 33.0 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KPI83064.1 - 1.1e-17 63.5 0.4 0.013 15.9 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KPI83064.1 - 2e-17 61.5 0.0 0.0015 18.8 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KPI83064.1 - 2.7e-12 46.6 5.5 0.0007 19.8 0.1 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) DUF2065 PF09838.9 KPI83064.1 - 0.098 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) LMBR1 PF04791.16 KPI83065.1 - 2.5e-32 112.5 30.7 6e-23 81.5 7.2 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein DUF3810 PF12725.7 KPI83065.1 - 0.0011 18.4 0.0 0.0011 18.4 0.0 3.8 1 1 3 5 5 5 2 Protein of unknown function (DUF3810) Neurensin PF14927.6 KPI83065.1 - 0.38 10.5 9.1 0.91 9.2 0.0 3.4 2 1 1 3 3 3 0 Neurensin Sigma_reg_N PF13800.6 KPI83065.1 - 7.7 6.9 8.4 9.5 6.6 0.1 3.7 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Acetyltransf_16 PF05301.11 KPI83066.1 - 5.7e-47 159.7 0.0 7e-47 159.4 0.0 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_1 PF00583.25 KPI83066.1 - 0.00071 19.8 0.0 0.0018 18.5 0.0 1.5 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI83066.1 - 0.0035 17.7 0.0 0.0065 16.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KPI83066.1 - 0.0097 15.8 0.0 0.043 13.8 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain SMI1_KNR4 PF09346.10 KPI83067.1 - 0.13 12.7 0.0 0.61 10.5 0.0 2.1 3 0 0 3 3 3 0 SMI1 / KNR4 family (SUKH-1) Ndc1_Nup PF09531.10 KPI83067.1 - 3.7 6.1 6.3 7 5.2 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SBP_bac_3 PF00497.20 KPI83068.1 - 0.095 12.1 0.0 7.5 5.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 G_glu_transpept PF01019.21 KPI83068.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Aldedh PF00171.22 KPI83069.1 - 2.6e-181 603.2 0.6 2.9e-181 603.0 0.6 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KPI83069.1 - 0.0067 15.9 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Ank_2 PF12796.7 KPI83070.1 - 5.2e-26 91.1 0.0 4.5e-13 49.6 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI83070.1 - 8.9e-22 77.2 0.1 3.9e-09 36.9 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI83070.1 - 4.4e-21 72.7 0.1 0.01 16.3 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 KPI83070.1 - 1.4e-14 53.7 0.3 0.034 14.6 0.0 6.2 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 KPI83070.1 - 6.5e-13 48.6 1.5 1.3e-05 25.4 0.0 5.4 2 2 2 5 5 5 3 Ankyrin repeats (many copies) DUF5470 PF17564.2 KPI83071.1 - 0.1 12.8 0.3 0.22 11.7 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5470) PSP1 PF04468.12 KPI83072.1 - 5.2e-12 45.9 0.4 1.1e-11 44.9 0.4 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Peptidase_C2 PF00648.21 KPI83073.1 - 6.7e-49 166.5 0.0 3.8e-29 101.7 0.0 2.3 2 0 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.22 KPI83073.1 - 2e-10 41.1 0.0 0.00043 20.5 0.0 3.3 3 0 0 3 3 3 2 Calpain large subunit, domain III FtsK_SpoIIIE PF01580.18 KPI83073.1 - 0.97 8.7 13.8 5.9 6.2 0.5 5.4 2 1 3 5 5 5 0 FtsK/SpoIIIE family DUF3253 PF11625.8 KPI83073.1 - 1.6 9.1 11.5 4.4 7.6 0.3 4.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3253) Calpain_III PF01067.22 KPI83074.1 - 1.1e-08 35.5 0.1 3.4e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 Calpain large subunit, domain III Peptidase_C2 PF00648.21 KPI83074.1 - 0.14 11.2 0.0 0.35 9.9 0.0 1.7 2 0 0 2 2 2 0 Calpain family cysteine protease Ribosomal_S7e PF01251.18 KPI83075.1 - 7.8e-63 211.6 2.8 8.9e-63 211.4 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e zf-UBP PF02148.19 KPI83076.1 - 2.8e-13 50.0 9.3 2.8e-13 50.0 9.3 2.1 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 KPI83076.1 - 6.7e-08 32.7 5.8 6.7e-08 32.7 5.8 2.5 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 KPI83076.1 - 3e-05 24.2 5.5 8.8e-05 22.7 5.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KPI83076.1 - 4.6e-05 23.2 6.3 4.6e-05 23.2 6.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KPI83076.1 - 0.0036 17.3 1.1 0.0097 15.9 1.1 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KPI83076.1 - 0.0064 16.3 14.7 0.013 15.3 2.1 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI83076.1 - 0.0096 15.8 5.2 0.0096 15.8 5.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI83076.1 - 0.011 15.7 5.0 0.011 15.7 5.0 2.6 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KPI83076.1 - 0.027 14.5 1.1 0.027 14.5 1.1 2.7 1 1 1 2 2 2 0 RING-type zinc-finger RecR PF02132.15 KPI83076.1 - 0.11 12.1 4.3 0.26 10.9 1.1 2.7 2 0 0 2 2 2 0 RecR protein zf-RING_11 PF17123.5 KPI83076.1 - 3.3 7.6 12.3 0.022 14.5 3.7 1.9 2 0 0 2 2 1 0 RING-like zinc finger Isochorismatase PF00857.20 KPI83077.1 - 1e-29 103.9 0.1 1.2e-29 103.7 0.1 1.0 1 0 0 1 1 1 1 Isochorismatase family AAA_18 PF13238.6 KPI83078.1 - 1.6e-06 28.7 0.6 6.2e-06 26.8 0.0 2.3 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 KPI83078.1 - 1.5e-05 25.5 0.4 4.5e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Thymidylate_kin PF02223.17 KPI83078.1 - 0.00071 19.3 0.1 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 Thymidylate kinase AAA_17 PF13207.6 KPI83078.1 - 0.0019 18.6 1.0 0.0081 16.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KPI83078.1 - 0.0088 16.5 1.8 0.062 13.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) mRNA_cap_C PF03919.15 KPI83078.1 - 0.17 12.6 0.0 0.5 11.0 0.0 1.8 2 0 0 2 2 2 0 mRNA capping enzyme, C-terminal domain Ribosomal_L15e PF00827.17 KPI83079.1 - 1.3e-85 286.0 7.2 1.5e-85 285.8 7.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 LRR_9 PF14580.6 KPI83080.1 - 1.1e-20 73.9 1.3 9.2e-16 57.8 0.1 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KPI83080.1 - 1.5e-17 63.4 24.7 2.7e-06 27.6 0.3 4.3 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83080.1 - 3.5e-10 39.5 13.1 1.7e-07 30.9 4.0 3.5 1 1 2 3 3 3 3 Leucine rich repeat phiKZ_IP PF12699.7 KPI83080.1 - 0.015 14.5 0.1 1.9 7.6 0.1 2.4 2 0 0 2 2 2 0 phiKZ-like phage internal head proteins LRR_6 PF13516.6 KPI83080.1 - 0.72 10.1 7.6 55 4.2 0.0 4.7 4 1 1 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KPI83080.1 - 7.5 7.5 8.1 2.4e+02 2.9 0.0 4.6 3 2 1 4 4 4 0 Leucine Rich Repeat Cyclin PF08613.11 KPI83081.1 - 2e-22 80.3 0.1 3.3e-22 79.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KPI83081.1 - 2.2e-05 24.2 0.1 3.6e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pol_alpha_B_N PF08418.10 KPI83082.1 - 4.1 7.3 9.5 0.18 11.8 2.6 1.9 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF773 PF05600.12 KPI83083.1 - 3.2e-11 42.7 20.6 4.2e-05 22.5 14.8 3.9 1 1 2 3 3 3 3 CDK5 regulatory subunit-associated protein 3 RRP36 PF06102.12 KPI83083.1 - 1.4 8.9 7.9 0.7 9.8 0.4 2.4 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 Lebercilin PF15619.6 KPI83083.1 - 1.9 8.1 8.2 6 6.5 1.9 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CENP-F_leu_zip PF10473.9 KPI83083.1 - 8.5 6.4 10.9 3.3 7.7 1.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATP-synt_DE_N PF02823.16 KPI83084.1 - 1.4e-13 50.5 0.0 2.7e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ribosomal_S11 PF00411.19 KPI83085.1 - 3e-31 108.1 2.4 3.7e-31 107.8 2.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 KPI83085.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) NinE PF05322.11 KPI83086.1 - 0.086 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NINE Protein ATP-sulfurylase PF01747.17 KPI83086.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 ATP-sulfurylase NGP1NT PF08153.12 KPI83087.1 - 6.2e-44 149.3 0.6 6.2e-44 149.3 0.6 1.7 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 KPI83087.1 - 7.4e-19 67.9 1.9 9.6e-15 54.7 0.0 3.4 3 1 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI83087.1 - 1.5e-05 24.6 0.1 0.0001 21.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KPI83087.1 - 0.00014 21.9 2.0 0.51 10.4 0.0 4.2 3 2 1 4 4 4 2 Dynamin family RsgA_GTPase PF03193.16 KPI83087.1 - 0.0017 18.3 0.0 0.029 14.3 0.0 2.3 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 KPI83087.1 - 0.0028 17.2 0.0 0.41 10.2 0.0 3.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KPI83087.1 - 0.0062 16.9 0.1 0.057 13.8 0.0 2.5 2 1 1 3 3 3 1 AAA ATPase domain Ras PF00071.22 KPI83087.1 - 0.095 12.3 0.2 3.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Ras family DUF2956 PF11169.8 KPI83087.1 - 4.2 7.6 7.4 0.38 11.0 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) DUF1771 PF08590.10 KPI83088.1 - 9.9 6.6 13.3 3.1 8.2 10.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) MFS_1 PF07690.16 KPI83089.1 - 6.5e-23 81.2 50.0 4.7e-15 55.4 21.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1304 PF06993.12 KPI83089.1 - 8.9 6.3 14.6 3.1 7.8 0.7 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1304) Y_phosphatase3 PF13350.6 KPI83091.1 - 1.2e-57 195.5 0.0 1.4e-57 195.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KPI83091.1 - 0.021 14.4 0.0 0.027 14.0 0.0 1.3 1 1 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KPI83091.1 - 0.042 14.0 0.0 0.12 12.5 0.0 1.7 1 1 0 1 1 1 0 Inositol hexakisphosphate DSPc PF00782.20 KPI83091.1 - 0.12 12.2 0.1 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KPI83092.1 - 4e-49 167.7 0.0 4.6e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KPI83092.1 - 0.0062 16.1 0.0 0.0086 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KPI83092.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate CHAP PF05257.16 KPI83093.1 - 1.1e-16 61.2 0.0 1.9e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 CHAP domain SH3_12 PF18129.1 KPI83093.1 - 0.07 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Xrn1 SH3-like domain CHAP PF05257.16 KPI83094.1 - 0.017 15.7 0.1 0.075 13.6 0.0 2.2 2 1 0 2 2 2 0 CHAP domain Rer1 PF03248.13 KPI83094.1 - 0.16 11.7 0.1 23 4.7 0.0 2.2 2 0 0 2 2 2 0 Rer1 family Tub PF01167.18 KPI83098.1 - 2e-35 122.7 0.0 3.6e-34 118.6 0.0 2.3 1 1 0 1 1 1 1 Tub family eIF_4EBP PF05456.11 KPI83098.1 - 0.05 13.5 2.7 12 5.9 2.3 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) CSD PF00313.22 KPI83099.1 - 8.9e-08 31.9 1.3 0.0046 16.8 0.1 3.9 3 0 0 3 3 3 2 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KPI83099.1 - 0.035 13.8 0.3 12 5.7 0.0 2.6 2 0 0 2 2 2 0 Ribonuclease B OB domain WD40 PF00400.32 KPI83100.1 - 0.014 16.3 5.5 2.5 9.1 0.1 4.5 4 0 0 4 4 4 0 WD domain, G-beta repeat APG6_N PF17675.1 KPI83101.1 - 0.0017 18.9 18.8 0.78 10.3 18.8 2.2 1 1 0 1 1 1 1 Apg6 coiled-coil region GAS PF13851.6 KPI83101.1 - 0.0041 16.5 6.5 0.0041 16.5 6.5 2.3 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding FliJ PF02050.16 KPI83101.1 - 0.006 16.8 14.2 0.052 13.8 1.6 2.4 1 1 1 2 2 2 2 Flagellar FliJ protein Filament PF00038.21 KPI83101.1 - 0.0077 15.8 13.7 0.061 12.9 6.4 2.1 1 1 1 2 2 2 2 Intermediate filament protein CENP-F_leu_zip PF10473.9 KPI83101.1 - 0.0093 16.0 17.5 0.045 13.8 17.1 2.0 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tup_N PF08581.10 KPI83101.1 - 0.011 16.0 2.0 0.03 14.6 0.4 2.3 1 1 1 2 2 2 0 Tup N-terminal HrpB7 PF09486.10 KPI83101.1 - 0.023 15.1 23.9 0.031 14.7 8.0 3.1 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF3450 PF11932.8 KPI83101.1 - 0.044 13.1 10.1 0.032 13.5 3.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CLZ PF16526.5 KPI83101.1 - 0.064 13.6 1.5 0.064 13.6 1.5 2.9 3 1 0 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Occludin_ELL PF07303.13 KPI83101.1 - 0.079 13.7 2.5 0.63 10.8 0.3 2.5 1 1 2 3 3 3 0 Occludin homology domain AAA_13 PF13166.6 KPI83101.1 - 0.088 11.4 4.8 0.092 11.4 4.8 1.2 1 0 0 1 1 1 0 AAA domain DUF724 PF05266.14 KPI83101.1 - 0.089 12.6 10.9 0.032 14.1 3.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) SHE3 PF17078.5 KPI83101.1 - 0.11 12.2 6.1 0.076 12.7 1.3 2.1 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 YlqD PF11068.8 KPI83101.1 - 0.16 12.4 2.1 0.18 12.2 0.5 1.8 1 1 1 2 2 2 0 YlqD protein UPF0242 PF06785.11 KPI83101.1 - 0.16 12.0 10.5 25 4.9 10.5 2.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 KPI83101.1 - 0.19 12.0 21.7 2 8.6 1.4 2.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) YabA PF06156.13 KPI83101.1 - 0.23 12.1 5.7 2.1 9.0 0.8 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Spc24 PF08286.11 KPI83101.1 - 0.36 11.1 9.4 0.085 13.1 0.9 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 PI3K_P85_iSH2 PF16454.5 KPI83101.1 - 0.39 10.3 8.7 0.073 12.7 1.6 2.3 1 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Fez1 PF06818.15 KPI83101.1 - 0.5 10.8 15.1 0.57 10.6 14.4 1.4 1 1 0 1 1 1 0 Fez1 TMF_TATA_bd PF12325.8 KPI83101.1 - 0.62 10.3 16.7 1 9.6 4.2 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Fungal_TACC PF12709.7 KPI83101.1 - 0.69 10.4 7.3 15 6.1 0.3 3.3 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins BRE1 PF08647.11 KPI83101.1 - 0.91 9.6 12.1 0.35 11.0 0.7 3.0 2 1 2 4 4 3 0 BRE1 E3 ubiquitin ligase Atg14 PF10186.9 KPI83101.1 - 0.98 8.4 15.5 3.6 6.6 3.8 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KPI83101.1 - 1.3 8.3 14.5 5 6.4 14.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 KPI83101.1 - 2 7.2 14.5 6.9 5.4 7.1 2.1 1 1 0 1 1 1 0 Spc7 kinetochore protein betaPIX_CC PF16523.5 KPI83101.1 - 2.1 8.2 9.6 3.5 7.5 2.8 3.1 1 1 1 2 2 2 0 betaPIX coiled coil YscO-like PF16789.5 KPI83101.1 - 2.8 7.9 16.6 2.3 8.3 4.6 2.3 1 1 1 2 2 2 0 YscO-like protein TMF_DNA_bd PF12329.8 KPI83101.1 - 3.8 7.6 11.8 4.2 7.4 1.0 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4472 PF14739.6 KPI83101.1 - 4.2 8.1 10.6 2.1 9.1 3.3 3.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4472) DHR10 PF18595.1 KPI83101.1 - 4.3 7.4 23.2 9.3 6.3 10.2 2.6 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain Cnn_1N PF07989.11 KPI83101.1 - 4.6 7.5 8.4 11 6.3 1.1 2.7 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Csm1_N PF18504.1 KPI83101.1 - 5.4 7.4 9.8 15 6.0 1.0 3.2 1 1 2 3 3 3 0 Csm1 N-terminal domain THOC7 PF05615.13 KPI83101.1 - 8.4 6.7 17.4 7.9 6.8 0.9 3.4 1 1 0 2 2 2 0 Tho complex subunit 7 SlyX PF04102.12 KPI83101.1 - 8.7 7.1 10.6 20 5.9 0.8 3.4 1 1 2 3 3 3 0 SlyX Guanylate_cyc PF00211.20 KPI83102.1 - 8.6e-17 61.3 0.0 9.3e-17 61.2 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Adeno_E1B_55K_N PF04623.12 KPI83103.1 - 0.18 12.5 0.8 1.1 10.0 0.2 2.6 2 0 0 2 2 2 0 Adenovirus E1B protein N-terminus Vps51 PF08700.11 KPI83104.1 - 0.056 13.5 0.0 0.056 13.5 0.0 3.2 4 0 0 4 4 4 0 Vps51/Vps67 YkyA PF10368.9 KPI83104.1 - 1.3 8.7 12.6 0.05 13.3 6.5 1.8 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Gp-FAR-1 PF05823.12 KPI83104.1 - 1.3 9.3 5.3 1.1 9.5 3.8 1.7 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) YabA PF06156.13 KPI83104.1 - 1.4 9.6 9.5 7.4 7.3 3.0 3.2 3 0 0 3 3 3 0 Initiation control protein YabA Phage_GP20 PF06810.11 KPI83104.1 - 1.5 8.6 12.2 1.7 8.5 5.9 3.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 ADIP PF11559.8 KPI83104.1 - 9.2 6.3 38.5 1 9.4 5.8 3.6 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding TPR_2 PF07719.17 KPI83105.1 - 7.3e-14 50.7 4.5 3.1e-05 23.8 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83105.1 - 1.5e-06 28.4 1.7 0.086 13.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83105.1 - 1e-05 25.3 2.8 0.25 11.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83105.1 - 1.1e-05 25.0 4.2 0.0097 15.7 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 KPI83105.1 - 1.5e-05 25.3 1.2 0.0055 17.3 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI83105.1 - 0.00047 20.0 9.5 0.045 13.8 0.2 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83105.1 - 0.00058 20.3 5.0 0.0063 17.0 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83105.1 - 0.0012 19.5 10.1 0.48 11.4 0.7 4.0 3 1 1 4 4 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83105.1 - 0.0067 16.6 3.3 0.055 13.7 0.2 3.0 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KPI83105.1 - 0.0067 16.3 5.8 4 7.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat PknG_TPR PF16918.5 KPI83105.1 - 0.01 14.6 0.0 0.017 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_4 PF07721.14 KPI83105.1 - 0.013 16.0 3.1 22 6.1 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 KPI83105.1 - 0.031 14.0 1.0 0.25 11.0 0.0 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_16 PF13432.6 KPI83105.1 - 0.08 13.6 6.1 4.8 7.9 0.2 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat MASE1 PF05231.14 KPI83106.1 - 0.046 12.8 1.2 2.5 7.2 0.4 2.4 2 0 0 2 2 2 0 MASE1 Jagunal PF07086.12 KPI83107.1 - 0.003 17.6 3.2 0.0037 17.4 3.2 1.1 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis Mfa1 PF17445.2 KPI83107.1 - 0.094 12.7 0.3 0.18 11.8 0.3 1.5 1 0 0 1 1 1 0 Mating factor A1 2TM PF13239.6 KPI83107.1 - 1.5 9.2 4.0 3.5 8.0 4.0 1.6 1 0 0 1 1 1 0 2TM domain DUF2534 PF10749.9 KPI83107.1 - 4.3 7.6 10.3 0.62 10.3 5.7 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF2534) GrlR PF16518.5 KPI83108.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 T3SS negative regulator,GrlR UCR_6-4kD PF08997.10 KPI83109.1 - 0.082 12.8 1.0 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GrlR PF16518.5 KPI83111.1 - 0.067 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 T3SS negative regulator,GrlR Arc_PepC PF06819.11 KPI83112.1 - 0.22 11.7 1.0 0.75 9.9 0.6 2.1 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminal Domain KELK PF15796.5 KPI83113.1 - 0.021 15.3 6.7 0.021 15.3 6.7 4.6 4 1 0 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HgmA PF04209.13 KPI83113.1 - 0.17 10.5 0.0 0.29 9.8 0.0 1.3 1 0 0 1 1 1 0 homogentisate 1,2-dioxygenase Prok-TraM PF09228.10 KPI83113.1 - 1.4 9.3 8.3 0.27 11.6 0.3 3.6 2 1 2 4 4 4 0 Prokaryotic Transcriptional repressor TraM DUF4239 PF14023.6 KPI83113.1 - 3.3 7.4 6.1 1.3 8.7 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) BLOC1_2 PF10046.9 KPI83113.1 - 5.6 7.3 10.2 6.6 7.1 2.3 4.0 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cnn_1N PF07989.11 KPI83113.1 - 6.4 7.0 24.7 15 5.9 3.0 6.3 4 2 2 6 6 6 0 Centrosomin N-terminal motif 1 IF-2B PF01008.17 KPI83114.1 - 1.4e-33 116.3 0.0 3.7e-33 114.9 0.0 1.9 2 1 0 2 2 2 1 Initiation factor 2 subunit family DUF5312 PF17239.2 KPI83114.1 - 0.096 11.0 2.7 2 6.7 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5312) DUF948 PF06103.11 KPI83114.1 - 2.3 8.5 6.6 0.24 11.7 0.5 2.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) KASH_CCD PF14662.6 KPI83114.1 - 6.2 6.6 11.8 0.17 11.7 4.2 1.9 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH zf-RING_2 PF13639.6 KPI83115.1 - 6.8e-10 39.1 14.0 1.2e-09 38.4 14.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KPI83115.1 - 2.4e-08 34.1 10.4 5.4e-08 33.0 10.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KPI83115.1 - 8.3e-07 28.9 6.3 1.7e-06 27.9 6.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KPI83115.1 - 4e-06 26.6 10.8 7.7e-06 25.7 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KPI83115.1 - 5.7e-05 22.8 7.3 0.00012 21.8 7.3 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 KPI83115.1 - 0.00018 21.3 10.8 0.00036 20.3 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KPI83115.1 - 0.00097 19.2 8.6 0.0023 18.0 8.6 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KPI83115.1 - 0.012 15.6 12.3 0.022 14.7 12.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KPI83115.1 - 0.15 11.9 11.2 0.28 11.1 11.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KPI83115.1 - 1.5 8.5 11.5 0.71 9.5 8.9 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KPI83115.1 - 5.7 7.2 9.0 4.3 7.6 5.7 2.2 1 1 1 2 2 2 0 FANCL C-terminal domain N2227 PF07942.12 KPI83116.1 - 7.6e-94 313.9 0.0 9.6e-94 313.6 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Myosin_head PF00063.21 KPI83118.1 - 8e-213 708.4 0.0 1.4e-212 707.6 0.0 1.4 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KPI83118.1 - 1e-06 28.6 0.0 0.00096 18.9 0.0 2.9 3 0 0 3 3 3 2 Unconventional myosin tail, actin- and lipid-binding WW PF00397.26 KPI83118.1 - 0.00034 20.6 0.1 0.00084 19.4 0.1 1.7 1 0 0 1 1 1 1 WW domain FYVE PF01363.21 KPI83118.1 - 0.0017 18.5 10.2 0.0041 17.2 10.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger IQ PF00612.27 KPI83118.1 - 0.0074 16.0 1.3 0.021 14.6 1.3 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_16 PF13191.6 KPI83118.1 - 0.011 16.2 2.9 0.021 15.2 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain HypA PF01155.19 KPI83118.1 - 0.097 12.7 0.9 0.29 11.1 0.9 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ABC_tran PF00005.27 KPI83118.1 - 0.63 10.5 2.4 0.64 10.5 0.1 2.1 2 0 0 2 2 2 0 ABC transporter ABC_tran PF00005.27 KPI83119.1 - 3.4e-31 108.6 0.0 5.1e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI83119.1 - 1.7e-05 24.4 0.0 0.00013 21.5 0.0 1.9 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KPI83119.1 - 0.00043 20.6 0.0 0.002 18.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain MoaE PF02391.17 KPI83119.1 - 0.0031 17.8 0.0 0.085 13.1 0.0 2.2 2 0 0 2 2 2 1 MoaE protein AAA_16 PF13191.6 KPI83119.1 - 0.0057 17.1 0.1 0.0092 16.4 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KPI83119.1 - 0.0061 16.6 0.1 0.031 14.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 KPI83119.1 - 0.0084 15.4 0.0 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA PF00004.29 KPI83119.1 - 0.013 15.9 0.0 0.14 12.6 0.0 2.4 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 KPI83119.1 - 0.015 15.5 0.3 0.59 10.4 0.3 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.18 KPI83119.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase G-alpha PF00503.20 KPI83119.1 - 0.066 12.4 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 KPI83119.1 - 0.078 12.7 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF5346 PF17281.2 KPI83120.1 - 0.087 12.9 0.4 0.18 11.8 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5346) Methyltr_RsmB-F PF01189.17 KPI83122.1 - 1.6e-21 76.9 0.0 1.8e-14 53.9 0.0 2.6 3 0 0 3 3 3 2 16S rRNA methyltransferase RsmB/F PUA PF01472.20 KPI83122.1 - 1.1e-05 25.3 0.3 2.1e-05 24.4 0.3 1.4 1 0 0 1 1 1 1 PUA domain Rab3-GTPase_cat PF13890.6 KPI83123.1 - 1.2e-38 132.3 0.1 2.5e-38 131.3 0.1 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Peptidase_C2 PF00648.21 KPI83124.1 - 1.6e-64 217.8 1.1 2.2e-64 217.3 1.1 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI83124.1 - 5.7e-23 81.3 0.1 1.2e-22 80.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) CesT PF05932.13 KPI83126.1 - 5e-12 46.0 0.2 9.6e-12 45.1 0.2 1.5 1 0 0 1 1 1 1 Tir chaperone protein (CesT) family ubiquitin PF00240.23 KPI83126.1 - 0.0086 15.8 0.0 0.025 14.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family FAM76 PF16046.5 KPI83126.1 - 0.083 12.2 11.4 0.63 9.3 0.3 2.2 1 1 1 2 2 2 0 FAM76 protein ATG16 PF08614.11 KPI83126.1 - 0.23 11.6 22.9 0.49 10.6 22.9 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FPP PF05911.11 KPI83126.1 - 0.35 9.0 15.0 0.017 13.3 5.6 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil MPS2 PF17060.5 KPI83126.1 - 0.49 9.6 4.1 0.7 9.1 4.1 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 MAD PF05557.13 KPI83126.1 - 0.5 8.7 21.4 0.97 7.7 21.0 1.6 1 1 1 2 2 2 0 Mitotic checkpoint protein HIP1_clath_bdg PF16515.5 KPI83126.1 - 0.68 10.6 22.0 0.37 11.4 8.7 2.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Bacillus_HBL PF05791.11 KPI83126.1 - 0.77 9.6 4.0 0.95 9.3 1.9 1.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) IFT57 PF10498.9 KPI83126.1 - 0.78 8.6 10.3 1.1 8.1 10.3 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 KPI83126.1 - 1.5 7.6 20.7 1 8.2 13.7 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF5082 PF16888.5 KPI83126.1 - 1.7 9.0 9.6 11 6.3 7.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Atg14 PF10186.9 KPI83126.1 - 2.3 7.3 13.9 3.6 6.6 13.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.15 KPI83126.1 - 4.3 7.7 21.2 2.6 8.5 7.1 2.3 1 1 1 2 2 2 0 Fez1 V_ATPase_I PF01496.19 KPI83126.1 - 5 4.9 4.3 7.1 4.4 4.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spore_III_AB PF09548.10 KPI83126.1 - 6.2 6.9 8.9 13 5.9 2.6 2.4 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) TPR_MLP1_2 PF07926.12 KPI83126.1 - 6.5 6.8 27.1 3.8 7.6 16.6 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein PEP-utilisers_N PF05524.13 KPI83126.1 - 8.4 6.6 12.0 11 6.3 6.9 2.6 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal WW PF00397.26 KPI83129.1 - 4.3e-05 23.5 4.8 8.6e-05 22.5 4.8 1.5 1 0 0 1 1 1 1 WW domain Elf1 PF05129.13 KPI83129.1 - 0.0023 17.9 0.4 0.0023 17.9 0.4 2.6 2 2 0 2 2 2 1 Transcription elongation factor Elf1 like zf-CCHC PF00098.23 KPI83129.1 - 0.023 14.8 1.8 0.023 14.8 1.8 4.0 4 1 0 4 4 4 0 Zinc knuckle eIF3g PF12353.8 KPI83129.1 - 1.1 9.6 19.0 0.25 11.8 4.2 3.0 2 2 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G zinc-ribbons_6 PF07191.12 KPI83129.1 - 2.5 8.1 15.1 2.8 8.0 9.4 2.8 2 1 0 2 2 2 0 zinc-ribbons Acetone_carb_G PF08882.11 KPI83129.1 - 5.8 7.1 8.3 11 6.2 0.0 3.6 2 1 1 4 4 4 0 Acetone carboxylase gamma subunit DZR PF12773.7 KPI83129.1 - 6.4 6.9 15.8 2.8 8.0 0.3 2.9 2 1 0 2 2 2 0 Double zinc ribbon zf-C2HE PF16278.5 KPI83129.1 - 6.7 7.2 9.2 17 6.0 1.3 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Photo_RC PF00124.19 KPI83130.1 - 0.099 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Photosynthetic reaction centre protein Amastin PF07344.11 KPI83131.1 - 9.3e-38 129.5 5.1 1.1e-37 129.3 5.1 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein Peptidase_C7 PF01830.18 KPI83131.1 - 0.0066 15.9 0.1 0.01 15.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase C7 family MARVEL PF01284.23 KPI83131.1 - 0.088 12.8 17.3 1.9 8.5 17.0 2.6 1 1 0 1 1 1 0 Membrane-associating domain DUF3040 PF11239.8 KPI83131.1 - 0.11 12.8 2.6 2.5 8.4 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF4173 PF13777.6 KPI83131.1 - 0.23 10.9 2.7 0.28 10.6 1.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4173) DUF1218 PF06749.12 KPI83131.1 - 0.43 11.1 11.6 0.2 12.2 1.2 3.2 1 1 0 3 3 3 0 Protein of unknown function (DUF1218) F-box-like PF12937.7 KPI83132.1 - 0.00011 22.0 0.6 0.00023 21.0 0.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KPI83132.1 - 0.018 14.9 1.1 0.043 13.7 1.1 1.6 1 0 0 1 1 1 0 F-box domain PHD PF00628.29 KPI83134.1 - 1.5e-06 28.0 8.4 2.6e-06 27.2 8.4 1.4 1 0 0 1 1 1 1 PHD-finger Acetyltransf_7 PF13508.7 KPI83134.1 - 0.00036 20.9 0.0 0.0013 19.2 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain PHD_4 PF16866.5 KPI83134.1 - 0.00043 20.3 3.8 0.0009 19.3 3.8 1.5 1 0 0 1 1 1 1 PHD-finger Acetyltransf_10 PF13673.7 KPI83134.1 - 0.052 13.5 0.0 0.56 10.2 0.0 2.3 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain RRM_1 PF00076.22 KPI83135.1 - 0.0051 16.6 0.1 0.06 13.2 0.0 2.5 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CysA_C_terminal PF17850.1 KPI83135.1 - 0.11 13.1 0.2 0.51 10.9 0.2 2.3 1 0 0 1 1 1 0 CysA C-terminal regulatory domain Thioredoxin_8 PF13905.6 KPI83137.1 - 4.8e-13 49.2 0.0 9.2e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KPI83137.1 - 5.8e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KPI83137.1 - 0.00014 21.6 0.0 0.00036 20.3 0.0 1.6 1 0 0 1 1 1 1 Redoxin S4 PF01479.25 KPI83138.1 - 2.8e-13 49.4 0.3 5.8e-13 48.3 0.3 1.6 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 KPI83138.1 - 1.1e-07 32.7 0.2 2.7e-07 31.4 0.2 1.8 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain TyrRSs_C PF16714.5 KPI83138.1 - 0.019 14.7 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Tyrosyl-tRNA synthetase C-terminal domain Pkinase PF00069.25 KPI83139.1 - 9.5e-41 139.9 0.0 1.1e-11 44.6 0.0 4.1 4 0 0 4 4 4 4 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83139.1 - 1.4e-23 83.5 0.0 2.1e-17 63.3 0.0 3.2 3 1 0 3 3 3 2 Protein tyrosine kinase NTP_transf_2 PF01909.23 KPI83140.1 - 0.0016 18.7 0.0 0.0036 17.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain EF-hand_1 PF00036.32 KPI83141.1 - 2.8e-28 95.3 9.1 1.6e-08 33.5 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KPI83141.1 - 4.4e-25 87.9 1.4 3.7e-12 46.5 1.5 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI83141.1 - 1.2e-23 80.9 4.3 1.3e-09 37.2 0.1 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KPI83141.1 - 2.3e-17 62.6 6.9 2e-11 43.6 1.7 3.5 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KPI83141.1 - 1e-10 40.6 13.8 2.3e-05 23.7 0.1 4.7 5 0 0 5 5 5 3 EF hand EF-hand_9 PF14658.6 KPI83141.1 - 2.7e-10 40.4 0.1 3.9e-06 27.1 0.0 2.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 KPI83141.1 - 1.7e-05 24.7 0.2 0.068 13.1 0.0 2.6 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SUB1_ProdP9 PF18213.1 KPI83141.1 - 0.0039 17.0 0.2 0.0067 16.2 0.2 1.3 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 EF-hand_14 PF17959.1 KPI83141.1 - 0.014 15.7 0.2 2.4 8.6 0.1 2.5 2 1 0 2 2 2 0 EF-hand domain DGF-1_C PF11040.8 KPI83141.1 - 0.03 14.3 1.3 0.59 10.2 0.2 2.4 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus His_Phos_1 PF00300.22 KPI83142.1 - 8.4e-31 107.2 0.1 1.2e-21 77.3 0.1 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 KPI83142.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) PilM PF07419.12 KPI83142.1 - 0.2 11.8 0.0 0.42 10.8 0.0 1.5 1 0 0 1 1 1 0 PilM LRR_4 PF12799.7 KPI83143.1 - 2.6e-11 43.6 0.0 0.0019 18.6 0.0 3.9 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83143.1 - 0.00037 20.2 1.3 0.13 12.1 0.2 3.4 3 0 0 3 3 3 2 Leucine rich repeat His_Phos_1 PF00300.22 KPI83144.1 - 1e-16 61.2 0.0 1.8e-10 40.8 0.0 2.6 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) zf-HIT PF04438.16 KPI83145.1 - 6.7e-06 25.9 15.9 1.1e-05 25.2 15.9 1.3 1 0 0 1 1 1 1 HIT zinc finger SAPS PF04499.15 KPI83145.1 - 0.02 13.7 1.3 0.029 13.1 1.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein zf-C2H2_11 PF16622.5 KPI83145.1 - 1.1 9.1 5.9 2.8 7.8 5.9 1.7 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-MYND PF01753.18 KPI83145.1 - 1.6 8.9 15.5 3.7 7.7 15.5 1.6 1 0 0 1 1 1 0 MYND finger CX9C PF16860.5 KPI83147.1 - 6.3e-06 26.1 0.2 1e-05 25.5 0.2 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 KPI83147.1 - 0.0019 18.1 0.8 0.012 15.6 0.8 1.9 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 KPI83147.1 - 0.02 15.0 0.5 5.7 7.2 0.0 2.2 2 0 0 2 2 2 0 CHCH domain GCK PF07802.11 KPI83147.1 - 0.04 14.3 0.1 0.059 13.8 0.1 1.4 1 0 0 1 1 1 0 GCK domain Plus-3 PF03126.18 KPI83149.1 - 0.00039 20.9 0.0 0.0019 18.7 0.0 2.0 1 1 1 2 2 2 1 Plus-3 domain PAD PF03068.15 KPI83149.1 - 0.005 15.9 0.6 0.0064 15.5 0.0 1.5 2 0 0 2 2 2 1 Protein-arginine deiminase (PAD) Bombinin PF05298.11 KPI83149.1 - 0.12 12.1 0.7 3 7.5 0.2 2.3 2 0 0 2 2 2 0 Bombinin TFIIA PF03153.13 KPI83149.1 - 0.26 11.2 22.6 0.97 9.4 12.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF948 PF06103.11 KPI83149.1 - 0.28 11.5 4.7 0.5 10.7 0.1 3.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Acetyltransf_10 PF13673.7 KPI83150.1 - 1.8e-07 31.2 0.0 2.6e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI83150.1 - 1.2e-06 28.8 0.0 1.7e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI83150.1 - 9.3e-06 26.0 0.0 1.6e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KPI83150.1 - 0.019 15.0 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DnaJ PF00226.31 KPI83152.1 - 2.3e-06 27.6 0.1 4.4e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain CH_2 PF06294.11 KPI83153.1 - 1.2e-26 92.7 0.1 2.8e-26 91.4 0.1 1.7 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 KPI83153.1 - 3.4e-05 23.6 0.0 6.4e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain RRM_1 PF00076.22 KPI83154.1 - 5.4e-10 38.9 0.0 1.1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MSP1_C PF07462.11 KPI83154.1 - 1.4 7.6 8.0 1.9 7.1 8.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus FYDLN_acid PF09538.10 KPI83154.1 - 2.4 8.9 12.5 10 6.8 12.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Hamartin PF04388.12 KPI83154.1 - 4 6.0 8.3 2.6 6.6 6.9 1.3 1 1 0 1 1 1 0 Hamartin protein Mito_carr PF00153.27 KPI83155.1 - 6.8e-25 86.8 1.7 3.3e-09 36.6 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PNP_UDP_1 PF01048.20 KPI83156.1 - 9.8e-44 149.4 0.3 1.3e-43 149.0 0.3 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily PseudoU_synth_2 PF00849.22 KPI83158.1 - 5.8e-25 88.2 0.2 1.1e-24 87.3 0.2 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF615 PF04751.14 KPI83158.1 - 0.0064 16.5 0.0 0.09 12.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF615) PRTase_2 PF15609.6 KPI83158.1 - 0.035 13.6 0.1 0.066 12.7 0.1 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase PcrB PF01884.17 KPI83158.1 - 0.065 12.7 0.0 0.25 10.8 0.0 1.8 2 0 0 2 2 2 0 PcrB family Exo70 PF03081.15 KPI83159.1 - 1.6e-05 24.1 0.1 8.1e-05 21.8 0.1 2.0 1 1 0 1 1 1 1 Exo70 exocyst complex subunit Dirigent PF03018.14 KPI83160.1 - 0.055 13.3 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 Dirigent-like protein Methyltransf_31 PF13847.6 KPI83161.1 - 2.8e-05 23.9 0.0 0.02 14.7 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KPI83161.1 - 5.9e-05 23.7 0.0 0.00011 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI83161.1 - 0.00013 22.5 0.0 0.0035 17.9 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI83161.1 - 0.019 15.7 0.0 2.6 8.8 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 KPI83161.1 - 0.026 13.8 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family BT1 PF03092.16 KPI83162.1 - 4.1e-198 658.9 11.0 5.5e-198 658.4 11.0 1.2 1 0 0 1 1 1 1 BT1 family BT1 PF03092.16 KPI83163.1 - 1.7e-177 590.8 10.4 1.9e-177 590.6 10.4 1.0 1 0 0 1 1 1 1 BT1 family DUF1168 PF06658.12 KPI83164.1 - 2.4e-05 24.2 18.2 3e-05 23.8 18.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Cwf_Cwc_15 PF04889.12 KPI83164.1 - 0.018 14.7 14.6 0.024 14.4 14.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein VIR_N PF15912.5 KPI83164.1 - 0.21 11.2 10.8 0.33 10.5 10.8 1.5 1 1 0 1 1 1 0 Virilizer, N-terminal Macoilin PF09726.9 KPI83164.1 - 0.62 8.6 16.5 0.67 8.4 16.5 1.0 1 0 0 1 1 1 0 Macoilin family Asp-B-Hydro_N PF05279.11 KPI83164.1 - 1.2 9.2 10.1 1.5 8.8 10.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PA26 PF04636.13 KPI83164.1 - 1.4 7.7 7.0 1.6 7.6 7.0 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF1635 PF07795.11 KPI83164.1 - 2 8.3 15.8 2.8 7.8 15.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Paramyxo_ncap PF00973.19 KPI83164.1 - 5.1 5.9 10.2 5.9 5.7 10.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Phage_Gp23 PF10669.9 KPI83164.1 - 5.4 7.4 12.3 9.2 6.6 12.3 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) RR_TM4-6 PF06459.12 KPI83164.1 - 5.5 6.7 11.3 6.2 6.6 11.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRA1 PF07304.11 KPI83165.1 - 1.7 8.5 8.0 21 4.9 1.2 3.7 3 0 0 3 3 3 0 Steroid receptor RNA activator (SRA1) TFIID-18kDa PF02269.16 KPI83168.1 - 0.043 13.9 0.5 0.081 13.0 0.5 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Pox_EPC_I2-L1 PF12575.8 KPI83168.1 - 0.11 12.8 1.8 66 3.8 0.1 3.0 2 1 1 3 3 3 0 Poxvirus entry protein complex L1 and I2 TRAM_LAG1_CLN8 PF03798.16 KPI83169.1 - 1.1e-41 142.8 12.6 1.1e-41 142.8 12.6 2.1 2 0 0 2 2 2 1 TLC domain Aa_trans PF01490.18 KPI83170.1 - 8.8e-41 140.0 11.5 1.1e-40 139.6 11.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI83170.1 - 1.8e-05 24.0 13.2 1.8e-05 24.0 13.2 2.4 2 1 0 2 2 2 2 Tryptophan/tyrosine permease family Peptidase_M20 PF01546.28 KPI83171.1 - 1.9e-37 129.0 0.0 2.7e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI83171.1 - 3.2e-18 65.6 0.0 5.4e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Citrate_synt PF00285.21 KPI83173.1 - 1.1e-97 327.3 0.0 1.4e-97 327.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Cytomega_gL PF01801.16 KPI83173.1 - 0.2 11.0 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein L PKcGMP_CC PF16808.5 KPI83175.1 - 0.0083 16.0 1.3 0.0083 16.0 1.3 6.8 9 0 0 9 9 9 1 Coiled-coil N-terminus of cGMP-dependent protein kinase GTP1_OBG PF01018.22 KPI83176.1 - 0.064 12.9 0.3 0.12 12.0 0.3 1.4 1 0 0 1 1 1 0 GTP1/OBG IZUMO PF15005.6 KPI83176.1 - 8.2 6.9 16.2 0.87 10.1 3.5 3.7 1 1 3 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated DUF4790 PF16037.5 KPI83176.1 - 8.8 6.9 13.4 1 9.9 0.4 4.1 4 1 1 5 5 5 0 Domain of unknown function (DUF4790) Sod_Fe_N PF00081.22 KPI83176.1 - 9.7 6.8 6.7 0.8 10.2 0.4 2.4 3 0 0 3 3 3 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Kinesin PF00225.23 KPI83177.1 - 5.5e-89 298.4 5.4 5.6e-77 258.9 0.4 5.2 6 0 0 6 6 6 2 Kinesin motor domain Microtub_bd PF16796.5 KPI83177.1 - 4.2e-16 59.2 0.0 1.9e-09 37.6 0.2 4.3 3 0 0 3 3 3 3 Microtubule binding Kinesin_assoc PF16183.5 KPI83177.1 - 0.00014 22.1 3.6 0.00014 22.1 3.6 9.8 2 1 5 8 8 8 1 Kinesin-associated Tup_N PF08581.10 KPI83177.1 - 0.0021 18.3 1.1 0.0021 18.3 1.1 16.7 14 3 1 16 16 16 4 Tup N-terminal cNMP_binding PF00027.29 KPI83178.1 - 1.2e-09 38.1 0.0 3.5e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PNP_UDP_1 PF01048.20 KPI83178.1 - 0.19 11.0 0.0 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Phosphorylase superfamily DUF1560 PF07597.11 KPI83179.1 - 0.057 13.4 0.0 0.22 11.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1560) ARD PF03079.14 KPI83180.1 - 7.9e-25 87.9 0.2 7.9e-25 87.9 0.2 2.1 2 0 0 2 2 2 1 ARD/ARD' family Cupin_2 PF07883.11 KPI83180.1 - 2.5e-05 23.9 0.0 5.8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 KPI83180.1 - 0.00076 19.4 0.1 0.0012 18.7 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 KPI83180.1 - 0.069 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_1 PF00190.22 KPI83180.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Cupin CDC45 PF02724.14 KPI83180.1 - 0.19 10.0 3.5 0.21 9.8 3.5 1.1 1 0 0 1 1 1 0 CDC45-like protein CAF-1_p150 PF11600.8 KPI83180.1 - 2.8 7.6 28.6 5.4 6.7 28.6 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PIEZO PF15917.5 KPI83180.1 - 4.6 6.6 9.5 0.47 9.9 5.0 1.6 2 0 0 2 2 2 0 Piezo Myb_DNA-bind_6 PF13921.6 KPI83181.1 - 0.00046 20.4 0.1 0.026 14.8 0.0 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain FN3_7 PF18447.1 KPI83181.1 - 0.034 14.5 0.2 0.09 13.1 0.2 1.7 1 0 0 1 1 1 0 Fibronectin type III domain WD40 PF00400.32 KPI83182.1 - 5.2e-06 27.1 6.1 0.0011 19.7 0.0 4.6 4 1 1 5 5 5 1 WD domain, G-beta repeat PHD PF00628.29 KPI83182.1 - 0.017 15.0 0.7 0.047 13.6 0.7 1.7 1 0 0 1 1 1 0 PHD-finger Lactonase PF10282.9 KPI83182.1 - 0.026 13.8 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 KPI83182.1 - 0.055 13.8 0.1 26 5.2 0.0 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 KPI83182.1 - 0.14 11.2 0.5 26 3.7 0.0 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1513) Tmemb_170 PF10190.9 KPI83183.1 - 8.4e-05 22.9 8.3 0.00011 22.5 8.3 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 RRM_1 PF00076.22 KPI83184.1 - 1.9e-29 101.3 0.0 4.2e-14 52.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI83184.1 - 0.00027 21.0 0.0 0.48 10.6 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 KPI83184.1 - 0.0044 17.0 0.0 3.5 7.7 0.0 2.9 3 0 0 3 3 3 2 RNA binding motif RNA_bind PF08675.11 KPI83184.1 - 0.016 15.2 0.1 0.66 10.0 0.0 2.5 2 1 0 2 2 2 0 RNA binding domain Nup35_RRM_2 PF14605.6 KPI83184.1 - 0.027 14.5 0.0 0.57 10.2 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Laminin_G_1 PF00054.23 KPI83184.1 - 0.18 12.0 0.0 1.5 9.1 0.0 2.3 3 0 0 3 3 3 0 Laminin G domain PHM7_cyt PF14703.6 KPI83184.1 - 0.44 10.8 2.2 11 6.3 0.3 3.0 2 2 2 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter CN_hydrolase PF00795.22 KPI83185.1 - 2.1e-48 164.9 0.0 2.6e-48 164.6 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Esterase PF00756.20 KPI83186.1 - 0.15 11.6 0.1 0.35 10.5 0.0 1.6 2 0 0 2 2 2 0 Putative esterase HSBP1 PF06825.12 KPI83187.1 - 0.00069 19.4 0.2 4.6 7.2 0.0 5.2 6 0 0 6 6 6 2 Heat shock factor binding protein 1 Phage_GP20 PF06810.11 KPI83187.1 - 0.001 18.9 2.0 0.001 18.9 2.0 7.4 6 2 2 8 8 8 1 Phage minor structural protein GP20 Apolipoprotein PF01442.18 KPI83187.1 - 0.0011 18.9 16.9 0.0011 18.9 16.9 7.4 3 2 4 7 7 7 3 Apolipoprotein A1/A4/E domain Tmemb_cc2 PF10267.9 KPI83187.1 - 0.0029 16.8 1.2 0.0029 16.8 1.2 6.5 3 2 0 4 4 4 1 Predicted transmembrane and coiled-coil 2 protein Golgin_A5 PF09787.9 KPI83187.1 - 0.0056 16.2 1.7 0.0056 16.2 1.7 8.9 5 3 1 9 9 9 2 Golgin subfamily A member 5 TraF_2 PF13729.6 KPI83187.1 - 2.8 7.2 10.4 1.4 8.2 0.2 4.2 4 1 0 4 4 4 0 F plasmid transfer operon, TraF, protein WD40 PF00400.32 KPI83190.1 - 5.4e-10 39.7 7.2 0.0033 18.2 0.2 5.0 5 1 0 5 5 5 3 WD domain, G-beta repeat DUF4533 PF15047.6 KPI83190.1 - 0.018 14.6 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) Frtz PF11768.8 KPI83190.1 - 0.078 11.3 0.0 0.13 10.5 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KPI83190.1 - 0.17 11.2 0.0 18 4.6 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Nitr_red_assoc PF09655.10 KPI83190.1 - 0.38 11.4 0.1 0.38 11.4 0.1 2.2 2 0 0 2 2 2 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) XRN_N PF03159.18 KPI83190.1 - 0.64 9.4 4.8 1.5 8.2 4.8 1.5 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus HEAT_EZ PF13513.6 KPI83191.1 - 6.2e-13 49.0 12.5 2.3e-06 27.9 0.3 7.3 7 2 3 10 10 9 3 HEAT-like repeat HEAT PF02985.22 KPI83191.1 - 1.1e-12 47.0 11.0 0.65 10.4 0.0 10.4 10 0 0 10 10 10 3 HEAT repeat HEAT_2 PF13646.6 KPI83191.1 - 3.9e-10 40.0 12.4 0.33 11.4 0.0 7.5 5 2 2 7 7 7 3 HEAT repeats IBN_N PF03810.19 KPI83191.1 - 1.2e-09 38.0 1.4 5.5e-08 32.6 0.0 4.0 3 1 1 4 4 4 1 Importin-beta N-terminal domain Arm PF00514.23 KPI83191.1 - 8.6e-09 35.2 5.5 0.44 10.7 0.0 5.7 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 KPI83191.1 - 1.5e-06 28.7 1.9 0.055 14.1 0.1 5.0 4 1 1 5 5 4 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 KPI83191.1 - 1.4e-05 23.9 0.2 0.0014 17.3 0.1 3.0 3 0 0 3 3 3 1 Adaptin N terminal region MMS19_C PF12460.8 KPI83191.1 - 0.00096 18.4 3.2 0.81 8.7 0.4 3.7 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal Rcd1 PF04078.13 KPI83191.1 - 0.0021 17.4 0.2 0.027 13.8 0.0 2.6 3 0 0 3 3 3 1 Cell differentiation family, Rcd1-like ApoLp-III PF07464.11 KPI83191.1 - 0.0032 17.6 0.1 0.14 12.3 0.1 3.5 3 0 0 3 3 3 1 Apolipophorin-III precursor (apoLp-III) V-ATPase_H_C PF11698.8 KPI83191.1 - 0.023 14.8 0.2 0.2 11.7 0.0 2.7 2 0 0 2 2 2 0 V-ATPase subunit H U3snoRNP10 PF12397.8 KPI83191.1 - 0.071 13.5 2.7 28 5.1 0.0 5.1 4 1 1 5 5 5 0 U3 small nucleolar RNA-associated protein 10 Telomere_reg-2 PF10193.9 KPI83191.1 - 3.1 8.3 5.3 43 4.6 0.1 4.0 3 1 0 3 3 3 0 Telomere length regulation protein CDT1_C PF16679.5 KPI83191.1 - 4.7 7.7 7.6 15 6.1 0.3 3.8 4 1 0 4 4 4 0 DNA replication factor Cdt1 C-terminal domain Ion_trans PF00520.31 KPI83192.1 - 3.1e-116 386.8 110.0 2.3e-37 128.5 22.9 4.2 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 KPI83192.1 - 0.0017 18.1 0.0 0.0061 16.3 0.0 2.1 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated DUF2383 PF09537.10 KPI83192.1 - 0.011 16.1 0.1 0.038 14.3 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) Thump_like PF18096.1 KPI83194.1 - 0.065 13.2 0.0 0.23 11.4 0.0 1.9 1 0 0 1 1 1 0 THUMP domain-like KH_1 PF00013.29 KPI83195.1 - 0.00044 20.0 0.4 0.0012 18.6 0.4 1.8 1 0 0 1 1 1 1 KH domain KH_8 PF17903.1 KPI83195.1 - 0.052 13.6 0.2 0.32 11.1 0.2 2.1 1 1 0 1 1 1 0 Krr1 KH1 domain SMC_N PF02463.19 KPI83197.1 - 1.4e-55 188.2 0.2 2e-55 187.6 0.2 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KPI83197.1 - 5.7e-25 87.9 0.7 2.5e-24 85.9 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KPI83197.1 - 2.9e-14 53.6 0.3 2.6e-06 27.5 0.1 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI83197.1 - 1.2e-06 29.2 53.6 0.041 14.4 37.8 4.9 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 KPI83197.1 - 2.2e-06 27.6 11.1 2.2e-06 27.6 11.1 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 KPI83197.1 - 1.2e-05 24.9 0.0 2.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zea_mays_MuDR PF05928.11 KPI83197.1 - 0.0036 17.0 2.3 0.0036 17.0 2.3 2.3 2 0 0 2 2 2 1 Zea mays MURB-like protein (MuDR) ABC_tran PF00005.27 KPI83197.1 - 0.11 13.0 0.0 0.11 13.0 0.0 5.1 4 3 0 4 4 3 0 ABC transporter AAA_22 PF13401.6 KPI83197.1 - 0.39 11.0 10.9 7.6 6.8 0.0 5.2 3 1 0 3 3 2 0 AAA domain AAA_5 PF07728.14 KPI83197.1 - 2.2 8.3 10.9 2.7 8.0 0.0 5.1 3 2 2 5 5 5 0 AAA domain (dynein-related subfamily) MHB PF16525.5 KPI83197.1 - 3.4 8.0 8.5 19 5.6 0.1 4.1 4 0 0 4 4 4 0 Haemophore, haem-binding FYVE PF01363.21 KPI83198.1 - 3.2e-21 75.2 7.1 4.8e-21 74.7 7.1 1.3 1 0 0 1 1 1 1 FYVE zinc finger IBR PF01485.21 KPI83198.1 - 0.0023 18.1 5.3 0.004 17.4 5.3 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zf-ribbon_3 PF13248.6 KPI83198.1 - 0.017 14.5 0.5 0.017 14.5 0.5 2.1 2 0 0 2 2 2 0 zinc-ribbon domain FYVE_2 PF02318.16 KPI83198.1 - 0.15 12.2 4.4 0.3 11.3 4.4 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger C1_1 PF00130.22 KPI83198.1 - 1.4 8.9 8.5 0.42 10.5 5.6 1.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) OrfB_Zn_ribbon PF07282.11 KPI83198.1 - 1.9 8.5 7.7 4.1 7.4 7.7 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.7 KPI83198.1 - 2 8.5 10.7 23 5.1 7.5 2.4 1 1 1 2 2 2 0 Double zinc ribbon zf-AN1 PF01428.16 KPI83198.1 - 3.4 7.9 11.3 16 5.8 11.4 2.1 1 1 1 2 2 2 0 AN1-like Zinc finger C1_2 PF03107.16 KPI83198.1 - 4.9 7.6 11.2 2.2 8.7 8.0 1.9 2 0 0 2 2 2 0 C1 domain Zn-ribbon_8 PF09723.10 KPI83198.1 - 7.1 6.8 9.4 19 5.5 0.3 2.8 1 1 2 3 3 3 0 Zinc ribbon domain zf-RING_2 PF13639.6 KPI83198.1 - 7.4 7.0 9.5 16 5.9 9.6 1.6 1 1 0 1 1 1 0 Ring finger domain Peptidase_S15 PF02129.18 KPI83199.1 - 3.8 7.0 9.2 0.34 10.5 2.6 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Pkinase PF00069.25 KPI83201.1 - 9.9e-38 130.0 0.0 2.2e-18 66.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83201.1 - 2.4e-11 43.4 0.0 1.6e-06 27.6 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase SCHIP-1 PF10148.9 KPI83201.1 - 0.057 13.0 1.4 0.14 11.7 1.4 1.6 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 zf-CCCH PF00642.24 KPI83202.1 - 3.9e-06 26.6 1.4 8e-06 25.6 1.4 1.6 1 1 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Phage_int_SAM_2 PF12834.7 KPI83202.1 - 0.026 15.2 0.2 0.047 14.4 0.2 1.4 1 0 0 1 1 1 0 Phage integrase, N-terminal DASH_Dad2 PF08654.10 KPI83202.1 - 0.069 13.6 1.6 0.11 13.0 1.6 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad2 zf-C4H2 PF10146.9 KPI83202.1 - 0.31 11.3 4.0 0.58 10.4 4.0 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein zf_CCCH_4 PF18345.1 KPI83202.1 - 1.2 9.3 6.3 0.28 11.3 1.1 2.1 2 0 0 2 2 2 0 Zinc finger domain Mago_nashi PF02792.14 KPI83203.1 - 7.7e-61 204.4 0.1 8.8e-61 204.2 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein p450 PF00067.22 KPI83204.1 - 1.1e-52 179.3 0.1 1.5e-52 178.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3925 PF13063.6 KPI83204.1 - 0.26 11.5 1.2 0.54 10.5 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3925) RF-1 PF00472.20 KPI83205.1 - 1.7e-07 31.1 1.0 7.1e-07 29.2 0.1 2.3 2 0 0 2 2 2 1 RF-1 domain Rhodanese PF00581.20 KPI83206.1 - 2.7e-05 24.7 0.0 4.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain LRR_6 PF13516.6 KPI83207.1 - 2.5e-21 73.9 16.7 0.74 10.0 0.0 11.3 11 0 0 11 11 11 8 Leucine Rich repeat LRR_4 PF12799.7 KPI83207.1 - 5.2e-07 29.9 3.7 0.73 10.3 0.0 6.5 7 0 0 7 7 7 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI83207.1 - 0.03 14.8 2.5 17 6.5 0.0 5.5 8 0 0 8 8 8 0 Leucine Rich Repeat BBL5 PF07289.11 KPI83209.1 - 3.5e-124 414.2 0.0 4.3e-124 413.9 0.0 1.1 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Voldacs PF03517.13 KPI83209.1 - 0.00058 20.0 0.3 0.23 11.6 0.0 2.6 2 0 0 2 2 2 2 Regulator of volume decrease after cellular swelling Vps36_ESCRT-II PF11605.8 KPI83209.1 - 0.0047 17.1 0.0 4.9 7.4 0.0 2.3 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 KPI83209.1 - 0.0091 16.3 0.0 5.1 7.5 0.0 2.3 2 0 0 2 2 2 2 Bacterial PH domain Metallophos PF00149.28 KPI83211.1 - 8.1e-28 98.3 0.1 1.7e-27 97.3 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf-TRAF PF02176.18 KPI83211.1 - 0.0023 18.6 4.1 0.0023 18.6 4.1 3.5 1 1 2 3 3 3 1 TRAF-type zinc finger EF-hand_1 PF00036.32 KPI83211.1 - 0.0035 16.8 0.1 0.091 12.3 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 KPI83211.1 - 0.0055 17.1 0.2 0.055 13.9 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair zf_UBZ PF18439.1 KPI83211.1 - 0.0075 15.8 0.0 0.0075 15.8 0.0 3.4 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger EF-hand_6 PF13405.6 KPI83211.1 - 0.0088 15.9 1.8 0.31 11.1 0.0 4.0 4 1 1 5 5 5 1 EF-hand domain Bacteriocin_IId PF09221.10 KPI83211.1 - 0.09 13.0 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Bacteriocin class IId cyclical uberolysin-like zf-ribbon_3 PF13248.6 KPI83211.1 - 0.1 12.0 0.0 0.1 12.0 0.0 3.0 3 0 0 3 3 3 0 zinc-ribbon domain PRP21_like_P PF12230.8 KPI83211.1 - 0.15 11.9 1.4 1.2 9.0 0.3 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein zinc_ribbon_2 PF13240.6 KPI83211.1 - 3.1 7.6 12.2 1.2 8.9 0.2 3.9 4 0 0 4 4 4 0 zinc-ribbon domain DUF2321 PF10083.9 KPI83211.1 - 3.2 7.4 6.9 2.4 7.8 4.5 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) FliJ PF02050.16 KPI83212.1 - 0.91 9.8 7.0 1.8 8.8 7.0 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein MFS_1 PF07690.16 KPI83213.1 - 3.2e-31 108.5 12.7 3.4e-18 65.7 0.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KPI83213.1 - 3.9e-08 32.6 12.1 0.0015 17.5 0.1 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 KPI83213.1 - 3.2e-05 22.7 22.1 0.0038 15.8 8.7 3.4 2 2 1 4 4 4 2 MFS/sugar transport protein MFS_4 PF06779.14 KPI83213.1 - 0.0013 18.1 11.4 0.011 15.1 1.6 2.8 2 2 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB ResB PF05140.14 KPI83213.1 - 0.12 11.1 0.0 0.21 10.3 0.0 1.4 1 0 0 1 1 1 0 ResB-like family DUF4149 PF13664.6 KPI83213.1 - 0.36 11.2 12.6 0.2 12.0 0.3 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) DUF4131 PF13567.6 KPI83213.1 - 0.67 9.6 8.2 5.2 6.7 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Gpr1_Fun34_YaaH PF01184.19 KPI83214.1 - 1.5e-29 103.1 16.6 1.9e-29 102.7 16.6 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family A1_Propeptide PF07966.12 KPI83214.1 - 0.21 11.5 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 A1 Propeptide LCE6A PF15858.5 KPI83214.1 - 0.29 11.9 2.4 0.59 10.9 0.8 2.4 1 1 1 2 2 2 0 Late cornified envelope protein 6A family Adap_comp_sub PF00928.21 KPI83215.1 - 8.4e-13 48.3 0.0 1.2e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KPI83215.1 - 2.3e-05 24.4 0.1 3.8e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SNAD4 PF18750.1 KPI83216.1 - 0.00066 19.8 0.2 0.0017 18.5 0.2 1.6 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC1 PF18769.1 KPI83216.1 - 0.025 14.8 0.1 0.058 13.7 0.1 1.5 1 0 0 1 1 1 0 APOBEC1 APOBEC3 PF18771.1 KPI83216.1 - 0.13 12.4 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 APOBEC3 APOBEC2 PF18772.1 KPI83216.1 - 0.16 12.0 0.2 0.31 11.1 0.2 1.4 1 0 0 1 1 1 0 APOBEC2 Arrestin_N PF00339.29 KPI83217.1 - 1.7e-15 57.4 0.0 2.4e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 KPI83217.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Arrestin_N terminal like Arrestin_N PF00339.29 KPI83218.1 - 9.8e-14 51.6 0.0 1.8e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KPI83218.1 - 0.0001 22.8 0.1 0.027 14.9 0.1 2.4 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 KPI83218.1 - 0.0019 17.9 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Rgp1 PF08737.10 KPI83218.1 - 0.0074 15.5 0.2 0.64 9.1 0.1 2.6 3 0 0 3 3 3 1 Rgp1 Spo0M PF07070.11 KPI83218.1 - 0.055 13.0 0.1 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 SpoOM protein DivIVA PF05103.13 KPI83219.1 - 2.4 8.3 9.7 6.7 6.8 1.3 3.6 3 1 1 4 4 4 0 DivIVA protein YlqD PF11068.8 KPI83219.1 - 2.7 8.4 10.2 0.39 11.1 5.2 2.0 2 0 0 2 2 2 0 YlqD protein NYD-SP28_assoc PF14775.6 KPI83219.1 - 2.9 8.0 9.8 9.2 6.5 0.8 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain Tfb5 PF06331.12 KPI83220.1 - 0.0008 19.3 0.0 0.18 11.8 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIIH complex subunit Tfb5 WW PF00397.26 KPI83221.1 - 3.5e-30 103.8 25.0 6.9e-13 48.4 1.1 4.6 4 1 0 4 4 4 4 WW domain Nup35_RRM_2 PF14605.6 KPI83223.1 - 7e-12 45.2 0.0 1.2e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF459 PF04311.13 KPI83225.1 - 0.13 11.2 1.3 9.7 5.1 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF459) GTP_EFTU PF00009.27 KPI83226.1 - 1.3e-53 181.4 0.1 2.4e-53 180.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KPI83226.1 - 9e-19 67.8 0.0 2.1e-17 63.5 0.0 2.6 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KPI83226.1 - 2.7e-08 34.1 0.7 6.5e-08 32.9 0.7 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KPI83226.1 - 0.0036 17.4 0.1 0.01 15.9 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KPI83226.1 - 0.046 13.5 0.3 4.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 KPI83226.1 - 0.11 12.9 0.6 8.2 6.9 0.2 2.4 2 1 0 2 2 2 0 AAA domain Tctex-1 PF03645.13 KPI83227.1 - 3.1e-17 62.7 0.0 6.6e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Tctex-1 family AAA_16 PF13191.6 KPI83228.1 - 0.054 13.9 8.1 0.021 15.2 1.2 3.1 2 1 0 2 2 2 0 AAA ATPase domain Cys_rich_KTR PF14205.6 KPI83228.1 - 0.13 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Cysteine-rich KTR ATPase_2 PF01637.18 KPI83228.1 - 0.27 11.1 0.0 0.49 10.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF4407 PF14362.6 KPI83228.1 - 0.69 9.2 4.9 0.083 12.2 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PAP2 PF01569.21 KPI83230.1 - 5.1e-23 81.3 1.7 5.1e-23 81.3 1.7 2.2 1 1 1 2 2 2 1 PAP2 superfamily RDD PF06271.12 KPI83230.1 - 0.04 14.1 2.0 0.13 12.4 1.3 2.1 1 1 0 1 1 1 0 RDD family DUF1772 PF08592.11 KPI83230.1 - 1.9 8.8 10.0 0.77 10.1 0.4 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF1772) PAP2 PF01569.21 KPI83231.1 - 7.3e-21 74.4 3.2 1.5e-20 73.3 3.2 1.5 1 0 0 1 1 1 1 PAP2 superfamily DUF4794 PF16042.5 KPI83231.1 - 0.17 12.9 0.6 0.33 12.0 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4794) NADH_oxidored PF08040.11 KPI83232.1 - 0.033 13.9 0.1 0.071 12.8 0.0 1.6 2 0 0 2 2 2 0 MNLL subunit SieB PF14163.6 KPI83232.1 - 0.042 13.3 0.1 0.065 12.7 0.1 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B Defensin_2 PF01097.18 KPI83232.1 - 0.26 11.3 1.5 0.46 10.4 1.5 1.3 1 0 0 1 1 1 0 Arthropod defensin EF-hand_7 PF13499.6 KPI83233.1 - 2.2e-12 47.3 0.4 0.031 14.7 0.0 5.2 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_1 PF00036.32 KPI83233.1 - 0.0029 17.0 0.1 0.34 10.6 0.1 3.8 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.6 KPI83233.1 - 0.0035 17.2 0.0 1.2 9.3 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_13 PF17958.1 KPI83233.1 - 0.018 14.8 0.1 3.5 7.5 0.0 3.2 4 0 0 4 4 4 0 EF-hand domain NUC PF18510.1 KPI83233.1 - 0.28 11.6 2.2 7.1 7.0 0.1 2.4 2 0 0 2 2 2 0 Nuclease domain Hep_59 PF07052.11 KPI83236.1 - 0.13 13.0 0.1 0.25 12.1 0.1 1.5 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 DnaJ PF00226.31 KPI83237.1 - 5.4e-08 32.9 0.0 1.5e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain PaREP1 PF05942.11 KPI83237.1 - 0.046 13.6 0.7 0.12 12.3 0.7 1.7 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family PrpR_N PF06506.11 KPI83240.1 - 0.015 14.9 0.4 0.047 13.3 0.1 1.8 2 0 0 2 2 2 0 Propionate catabolism activator DUF3646 PF12362.8 KPI83240.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal PseudoU_synth_2 PF00849.22 KPI83242.1 - 6.7e-18 65.3 0.0 7e-09 36.0 0.0 2.7 2 1 0 2 2 2 2 RNA pseudouridylate synthase DUF5629 PF18629.1 KPI83242.1 - 0.09 13.3 0.1 0.33 11.5 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5629) zf-RING_2 PF13639.6 KPI83243.1 - 1.4e-07 31.7 6.5 1.5e-05 25.3 3.4 2.5 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_3 PF13920.6 KPI83243.1 - 8.8e-07 28.7 5.4 1.2e-05 25.1 2.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI83243.1 - 0.00066 19.5 7.1 0.0021 17.9 2.6 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KPI83243.1 - 0.0025 17.6 3.1 0.0025 17.6 3.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI83243.1 - 0.0058 16.6 5.9 0.0095 15.9 2.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 KPI83243.1 - 0.0064 16.2 3.7 0.13 12.0 0.4 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KPI83243.1 - 0.017 15.0 8.8 0.027 14.3 4.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Snapin_Pallidin PF14712.6 KPI83243.1 - 0.018 15.4 1.1 1.5 9.3 0.1 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DHR10 PF18595.1 KPI83243.1 - 0.034 14.2 0.9 0.034 14.2 0.9 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 KPI83243.1 - 0.052 12.4 1.6 0.075 11.9 1.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 KPI83243.1 - 0.089 13.4 1.0 4 8.1 0.1 2.7 2 0 0 2 2 2 0 SlyX Uds1 PF15456.6 KPI83243.1 - 0.092 12.9 6.9 0.17 12.0 6.9 1.5 1 0 0 1 1 1 0 Up-regulated During Septation PspA_IM30 PF04012.12 KPI83243.1 - 0.11 12.0 8.2 0.47 10.0 8.2 1.9 1 1 0 1 1 1 0 PspA/IM30 family Prefoldin PF02996.17 KPI83243.1 - 0.14 12.0 1.1 2.8 7.9 0.1 2.2 2 0 0 2 2 2 0 Prefoldin subunit Baculo_IE-1 PF05290.11 KPI83243.1 - 0.41 10.6 1.6 0.86 9.5 1.6 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) YscO PF07321.12 KPI83243.1 - 0.54 10.2 12.8 0.72 9.8 1.2 2.3 2 0 0 2 2 2 0 Type III secretion protein YscO Atg14 PF10186.9 KPI83243.1 - 0.93 8.5 8.3 9.2 5.2 8.4 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4200 PF13863.6 KPI83243.1 - 1.2 9.5 3.4 8.7 6.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4140 PF13600.6 KPI83243.1 - 1.9 9.0 6.2 19 5.8 0.6 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Rad50_zn_hook PF04423.14 KPI83243.1 - 2.8 7.9 4.7 7.7 6.4 0.6 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-rbx1 PF12678.7 KPI83243.1 - 3.4 8.0 6.8 1.2 9.5 2.4 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain APG6_N PF17675.1 KPI83243.1 - 3.6 8.1 6.4 4.9 7.7 0.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region zf-RING_UBOX PF13445.6 KPI83243.1 - 4.5 7.4 16.2 3.6 7.7 4.5 3.0 2 1 1 3 3 3 0 RING-type zinc-finger FAM176 PF14851.6 KPI83244.1 - 2.1 8.0 12.3 5.6 6.6 0.7 3.3 3 0 0 3 3 3 0 FAM176 family Pescadillo_N PF06732.11 KPI83246.1 - 1.2e-87 293.9 2.4 2.8e-87 292.7 2.4 1.5 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 KPI83246.1 - 7.7e-11 42.3 0.0 1.7e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KPI83246.1 - 1e-06 28.9 0.0 3.2e-06 27.3 0.0 2.0 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT PF00533.26 KPI83246.1 - 2e-05 24.9 0.0 5.1e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Pep_deformylase PF01327.21 KPI83247.1 - 3e-17 62.7 0.0 9.8e-17 61.0 0.0 1.8 1 1 0 1 1 1 1 Polypeptide deformylase DUF1523 PF07509.11 KPI83247.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Y_phosphatase2 PF03162.13 KPI83249.1 - 1.3e-49 168.0 0.0 1.8e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KPI83249.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Ribosomal_L35Ae PF01247.18 KPI83251.1 - 2.1e-33 114.3 0.8 3.4e-33 113.7 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 KPI83251.1 - 4.8e-06 26.7 0.5 0.053 13.7 0.0 2.4 2 1 0 2 2 2 2 RimM N-terminal domain DUF4115 PF13464.6 KPI83251.1 - 0.037 14.2 0.0 0.08 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) Thymidylate_kin PF02223.17 KPI83252.1 - 1.5e-13 50.8 0.0 3.1e-13 49.8 0.0 1.5 1 1 0 1 1 1 1 Thymidylate kinase dNK PF01712.19 KPI83252.1 - 0.057 13.3 0.2 0.38 10.6 0.2 2.0 1 1 0 1 1 1 0 Deoxynucleoside kinase MMS19_N PF14500.6 KPI83253.1 - 1e-44 153.1 5.8 2e-44 152.2 4.1 2.1 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II HIT PF01230.23 KPI83257.1 - 1.1e-11 45.4 0.2 1e-10 42.2 0.1 2.6 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 KPI83257.1 - 8.7e-06 26.2 0.0 2.7e-05 24.6 0.0 1.8 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Raf1_N PF18578.1 KPI83257.1 - 0.025 15.1 0.5 1 9.8 0.1 2.5 1 1 1 2 2 2 0 Rubisco accumulation factor 1 alpha helical domain 5-FTHF_cyc-lig PF01812.20 KPI83258.1 - 4.4e-14 52.7 0.5 1.4e-09 38.1 0.0 3.2 3 0 0 3 3 3 3 5-formyltetrahydrofolate cyclo-ligase family FAM220 PF15487.6 KPI83260.1 - 0.13 11.9 3.3 0.3 10.7 2.6 1.8 2 0 0 2 2 2 0 FAM220 family SAGA-Tad1 PF12767.7 KPI83260.1 - 1.4 8.6 8.3 0.25 11.0 4.0 1.9 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit TFIIA PF03153.13 KPI83260.1 - 5.6 6.8 18.4 0.17 11.9 8.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_2 PF07724.14 KPI83262.1 - 1.6e-51 174.9 0.0 3.3e-49 167.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KPI83262.1 - 7.3e-33 112.6 3.4 7.3e-33 112.6 3.4 2.3 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 KPI83262.1 - 3.9e-23 82.3 0.0 4.8e-13 49.7 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KPI83262.1 - 3.6e-21 75.0 0.1 1.7e-20 72.9 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 KPI83262.1 - 3.7e-17 62.6 0.0 4.9e-11 42.8 0.0 3.4 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI83262.1 - 1.1e-09 38.9 6.3 8.5e-05 23.0 0.2 4.4 3 3 0 4 4 2 2 AAA ATPase domain AAA_22 PF13401.6 KPI83262.1 - 7e-09 36.1 6.0 0.0014 18.9 0.0 4.9 4 3 0 4 4 3 2 AAA domain AAA_7 PF12775.7 KPI83262.1 - 4.9e-07 29.4 0.0 0.0057 16.2 0.0 2.9 3 1 0 3 3 3 2 P-loop containing dynein motor region AAA_18 PF13238.6 KPI83262.1 - 2.5e-05 24.8 0.5 0.081 13.5 0.0 3.3 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 KPI83262.1 - 3e-05 23.8 0.0 0.041 13.6 0.0 2.9 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KPI83262.1 - 5e-05 23.6 0.0 0.74 10.2 0.0 3.0 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.21 KPI83262.1 - 7.3e-05 22.2 0.1 1.1 8.6 0.0 3.5 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KPI83262.1 - 0.00021 21.0 0.0 0.11 12.2 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 KPI83262.1 - 0.00033 20.7 0.0 0.4 10.7 0.0 3.1 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KPI83262.1 - 0.00063 19.5 0.1 2.9 7.6 0.0 3.5 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 KPI83262.1 - 0.00064 19.6 0.0 0.5 10.2 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 KPI83262.1 - 0.00093 19.2 0.5 4.9 7.1 0.0 3.9 3 1 0 4 4 3 0 Type III restriction enzyme, res subunit NACHT PF05729.12 KPI83262.1 - 0.0015 18.5 0.0 0.06 13.3 0.0 3.0 3 0 0 3 3 2 1 NACHT domain Roc PF08477.13 KPI83262.1 - 0.0018 18.5 0.0 1.3 9.2 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DNA_pol3_delta2 PF13177.6 KPI83262.1 - 0.0032 17.3 4.2 1.8 8.4 0.0 3.6 3 1 0 3 3 3 1 DNA polymerase III, delta subunit Macoilin PF09726.9 KPI83262.1 - 0.0048 15.5 4.6 0.0074 14.9 4.6 1.3 1 0 0 1 1 1 1 Macoilin family TIP49 PF06068.13 KPI83262.1 - 0.0049 16.1 0.4 1 8.5 0.0 3.1 2 1 1 3 3 3 1 TIP49 P-loop domain AAA_19 PF13245.6 KPI83262.1 - 0.005 17.2 0.5 0.49 10.7 0.1 3.2 2 2 1 3 3 3 1 AAA domain TsaE PF02367.17 KPI83262.1 - 0.0062 16.5 0.0 2.2 8.3 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 KPI83262.1 - 0.0065 15.7 0.1 0.22 10.6 0.0 3.0 4 0 0 4 4 3 1 Protein of unknown function (DUF815) Torsin PF06309.11 KPI83262.1 - 0.0085 16.2 0.0 0.029 14.5 0.0 1.8 2 0 0 2 2 1 1 Torsin RsgA_GTPase PF03193.16 KPI83262.1 - 0.0089 15.9 0.0 3.2 7.6 0.0 3.0 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 KPI83262.1 - 0.01 16.1 0.1 2.8 8.1 0.0 3.3 3 1 0 4 4 2 0 AAA domain ABC_tran PF00005.27 KPI83262.1 - 0.011 16.2 0.7 9.6 6.7 0.0 3.6 3 1 0 3 3 3 0 ABC transporter AAA_24 PF13479.6 KPI83262.1 - 0.013 15.2 0.0 7 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KPI83262.1 - 0.013 15.6 0.0 8.2 6.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 KPI83262.1 - 0.014 15.1 0.0 1.4 8.5 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KPI83262.1 - 0.024 14.2 0.1 1.2 8.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 KPI83262.1 - 0.026 14.4 0.0 5.3 6.9 0.0 2.9 3 0 0 3 3 2 0 NTPase 4HB_MCP_1 PF12729.7 KPI83262.1 - 0.028 14.0 5.9 0.057 13.0 5.9 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction AAA_29 PF13555.6 KPI83262.1 - 0.04 13.7 0.0 13 5.6 0.0 2.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ribosomal_S7 PF00177.21 KPI83262.1 - 0.047 13.3 0.0 0.15 11.7 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e AAA_6 PF12774.7 KPI83262.1 - 0.049 12.6 0.1 0.23 10.4 0.0 2.1 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region ATP_bind_1 PF03029.17 KPI83262.1 - 0.14 11.9 0.6 4.9 6.9 0.0 2.7 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.6 KPI83262.1 - 0.54 10.7 15.5 19 5.7 0.0 3.2 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KPI83262.1 - 2 8.9 5.8 7.8 6.9 0.0 3.7 3 1 1 4 4 2 0 AAA domain V_ATPase_I PF01496.19 KPI83262.1 - 6.1 4.6 7.0 8.7 4.1 7.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 KPI83262.1 - 6.2 5.8 9.5 10 5.1 9.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YfcL PF08891.11 KPI83263.1 - 0.079 13.3 0.0 0.079 13.3 0.0 3.9 3 0 0 3 3 3 0 YfcL protein Ycf34 PF10718.9 KPI83263.1 - 0.091 13.5 0.2 0.54 11.0 0.2 2.4 1 0 0 1 1 1 0 Hypothetical chloroplast protein Ycf34 IL17 PF06083.11 KPI83263.1 - 0.25 11.9 2.0 0.92 10.0 0.8 2.7 2 0 0 2 2 2 0 Interleukin-17 FmiP_Thoc5 PF09766.9 KPI83264.1 - 0.0014 18.0 1.3 0.0023 17.3 1.3 1.3 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Macoilin PF09726.9 KPI83264.1 - 0.0091 14.6 2.7 0.012 14.2 2.7 1.2 1 0 0 1 1 1 1 Macoilin family Cortex-I_coil PF09304.10 KPI83264.1 - 0.014 15.6 1.0 0.053 13.8 1.0 2.0 1 0 0 1 1 1 0 Cortexillin I, coiled coil RMI1_N PF08585.12 KPI83264.1 - 0.023 14.5 0.2 0.049 13.4 0.2 1.5 1 0 0 1 1 1 0 RecQ mediated genome instability protein KxDL PF10241.9 KPI83264.1 - 0.073 13.3 3.3 3.9 7.8 2.4 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein V-SNARE_C PF12352.8 KPI83264.1 - 1.6 9.1 6.7 2.6 8.4 3.4 2.4 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus AAA_assoc_C PF09821.9 KPI83264.1 - 5.3 7.6 5.9 9.8 6.7 0.6 2.4 1 1 1 2 2 2 0 C-terminal AAA-associated domain HTH_9 PF08221.11 KPI83265.1 - 0.0013 18.8 2.9 0.43 10.7 0.0 4.1 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain Urb2 PF10441.9 KPI83265.1 - 0.057 13.4 0.7 0.4 10.6 0.1 2.2 2 0 0 2 2 2 0 Urb2/Npa2 family Anemone_cytotox PF06369.12 KPI83265.1 - 0.14 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Sea anemone cytotoxic protein Mito_carr PF00153.27 KPI83266.1 - 4.8e-24 84.1 0.6 1.3e-13 50.6 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Nop14 PF04147.12 KPI83267.1 - 0.0051 15.1 5.6 0.0061 14.9 5.6 1.1 1 0 0 1 1 1 1 Nop14-like family ATG16 PF08614.11 KPI83268.1 - 0.00011 22.4 86.1 0.012 15.8 18.9 5.3 1 1 3 5 5 5 4 Autophagy protein 16 (ATG16) HALZ PF02183.18 KPI83268.1 - 0.16 12.2 0.0 0.16 12.2 0.0 8.8 9 1 1 10 10 10 0 Homeobox associated leucine zipper DcpS PF05652.12 KPI83268.1 - 8.5 7.3 7.9 18 6.2 0.1 4.1 3 1 0 3 3 3 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal EF-hand_6 PF13405.6 KPI83269.1 - 4.1e-06 26.3 1.8 0.15 12.1 0.1 4.2 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KPI83269.1 - 0.00014 21.2 0.2 1.8 8.3 0.0 3.9 3 1 1 4 4 4 2 EF hand EF-hand_5 PF13202.6 KPI83269.1 - 0.017 14.6 0.2 0.79 9.3 0.0 3.2 3 0 0 3 3 3 0 EF hand EF-hand_7 PF13499.6 KPI83269.1 - 0.05 14.1 0.6 0.34 11.4 0.2 2.4 2 1 0 2 2 2 0 EF-hand domain pair RIIa PF02197.17 KPI83269.1 - 0.097 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit LRR_6 PF13516.6 KPI83270.1 - 4.6e-16 57.4 0.5 0.038 14.1 0.1 6.1 6 0 0 6 6 6 4 Leucine Rich repeat GBV-C_env PF12786.7 KPI83270.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 GB virus C genotype envelope Laminin_G_2 PF02210.24 KPI83271.1 - 0.00021 21.9 0.0 1.1 9.8 0.0 2.9 2 0 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.6 KPI83271.1 - 0.00053 20.2 0.0 0.0022 18.1 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily IQ PF00612.27 KPI83271.1 - 0.021 14.6 0.0 0.075 12.9 0.0 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF2868 PF11067.8 KPI83271.1 - 8.9 5.7 7.0 1.7 8.1 3.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) Cyt-b5 PF00173.28 KPI83273.1 - 1.9e-21 76.0 0.2 2.5e-21 75.6 0.2 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LigB PF02900.18 KPI83274.1 - 6.3e-28 97.6 0.0 8.9e-28 97.1 0.0 1.2 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase zf-PARP PF00645.18 KPI83275.1 - 1.9e-19 70.3 0.2 3.9e-19 69.3 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-CCHH PF10283.9 KPI83275.1 - 1.7e-12 47.1 1.1 2.8e-12 46.4 1.1 1.3 1 0 0 1 1 1 1 PBZ domain NARP1 PF12569.8 KPI83276.1 - 1.4e-84 284.8 14.3 2.1e-80 271.1 7.4 2.9 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KPI83276.1 - 8.3e-15 53.6 10.1 0.00029 20.7 0.0 7.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83276.1 - 8.2e-13 47.6 6.3 8.2e-05 22.3 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83276.1 - 6.4e-10 39.0 17.4 0.005 17.6 0.1 8.4 7 2 2 9 9 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83276.1 - 4.7e-08 33.4 17.6 0.19 12.3 0.0 6.3 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI83276.1 - 4.8e-08 33.0 7.0 0.0018 18.4 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83276.1 - 4.8e-07 30.0 13.5 0.039 14.3 2.2 5.6 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI83276.1 - 2e-06 27.8 3.1 0.35 11.4 0.0 5.6 8 0 0 8 8 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83276.1 - 2.8e-06 27.5 16.4 3 8.2 0.4 6.0 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KPI83276.1 - 5.6e-06 26.0 3.8 0.1 12.7 0.0 5.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83276.1 - 1.9e-05 24.5 6.4 0.95 9.8 0.1 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83276.1 - 5.5e-05 23.7 20.9 0.014 16.1 3.2 6.3 7 1 1 8 8 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI83276.1 - 0.00079 19.5 7.3 0.94 9.6 0.0 4.8 6 0 0 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat CdiI_2 PF18593.1 KPI83276.1 - 0.0065 17.1 0.1 0.05 14.3 0.0 2.4 2 0 0 2 2 2 1 CdiI immunity protein TPR_11 PF13414.6 KPI83276.1 - 0.0078 15.9 4.6 2.2 8.0 0.0 4.7 5 0 0 5 5 5 1 TPR repeat TPR_10 PF13374.6 KPI83276.1 - 0.014 15.3 1.2 1.6 8.7 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1771 PF08590.10 KPI83276.1 - 0.26 11.7 8.9 3.9 7.9 4.3 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1771) DnaJ PF00226.31 KPI83277.1 - 2.9e-05 24.1 0.0 6.6e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain SlyX PF04102.12 KPI83278.1 - 0.015 15.9 4.6 0.015 15.9 4.6 2.3 1 1 1 2 2 2 0 SlyX Macoilin PF09726.9 KPI83278.1 - 0.046 12.3 14.8 0.0042 15.7 6.8 2.0 2 0 0 2 2 2 0 Macoilin family BILBO1_N PF18281.1 KPI83279.1 - 4.5e-34 116.8 0.4 8.6e-34 115.9 0.4 1.5 1 0 0 1 1 1 1 BILBO1 N-terminal domain CENP-F_leu_zip PF10473.9 KPI83279.1 - 0.0084 16.1 11.0 0.041 13.9 9.9 2.0 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tox-ODYAM1 PF15642.6 KPI83279.1 - 4 6.3 5.2 5.9 5.7 5.2 1.2 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus SIP1 PF04938.12 KPI83280.1 - 2e-06 27.7 0.0 6.9e-06 25.9 0.0 1.9 2 1 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) ANAPC3 PF12895.7 KPI83282.1 - 0.03 14.5 0.6 0.14 12.4 0.6 2.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2951 PF11166.8 KPI83282.1 - 9 6.6 7.8 6.8 7.0 5.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Armet PF10208.9 KPI83283.1 - 0.0044 16.9 0.0 0.0071 16.3 0.0 1.2 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding DUF3522 PF12036.8 KPI83284.1 - 3.2e-31 109.1 10.9 4.2e-31 108.7 10.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) DUF5134 PF17197.4 KPI83284.1 - 0.02 14.8 0.7 0.029 14.3 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) Corona_M PF01635.18 KPI83284.1 - 0.14 11.5 3.8 0.21 10.9 3.8 1.3 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein DUF3522 PF12036.8 KPI83285.1 - 6.2e-39 134.2 10.4 7.9e-39 133.9 10.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) GT87 PF09594.10 KPI83285.1 - 0.011 15.5 6.1 0.037 13.7 3.9 2.3 1 1 1 2 2 2 0 Glycosyltransferase family 87 DUF3159 PF11361.8 KPI83285.1 - 0.055 13.2 0.2 0.055 13.2 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3159) DUF202 PF02656.15 KPI83285.1 - 0.084 13.3 0.1 0.084 13.3 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Ceramidase PF05875.12 KPI83285.1 - 0.11 11.9 7.0 0.36 10.2 0.0 2.5 2 1 0 2 2 2 0 Ceramidase DUF2070 PF09843.9 KPI83285.1 - 0.12 10.6 2.5 0.16 10.2 2.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4401 PF14351.6 KPI83285.1 - 0.12 11.7 8.2 0.32 10.3 7.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4401) HlyIII PF03006.20 KPI83285.1 - 0.16 11.6 14.5 6.1 6.5 14.4 2.3 1 1 0 1 1 1 0 Haemolysin-III related zf-MIZ PF02891.20 KPI83285.1 - 0.22 11.3 2.1 0.41 10.4 0.1 2.2 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_2 PF13639.6 KPI83286.1 - 3e-10 40.2 7.5 3e-10 40.2 7.5 2.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI83286.1 - 1.7e-07 30.9 7.3 1.7e-07 30.9 7.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI83286.1 - 2.3e-07 30.6 6.3 2.3e-07 30.6 6.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI83286.1 - 5.4e-07 29.5 7.6 5.4e-07 29.5 7.6 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 KPI83286.1 - 6.9e-07 28.9 4.7 6.9e-07 28.9 4.7 2.7 4 0 0 4 4 4 1 RING-like zinc finger zf-rbx1 PF12678.7 KPI83286.1 - 1.1e-06 28.8 8.8 1.1e-06 28.8 8.8 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KPI83286.1 - 1.2e-05 25.1 3.1 1.2e-05 25.1 3.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI83286.1 - 5.1e-05 23.3 6.2 0.00016 21.8 6.2 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KPI83286.1 - 7.6e-05 22.6 4.8 7.6e-05 22.6 4.8 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KPI83286.1 - 0.00048 20.1 5.3 0.00055 19.9 4.1 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 KPI83286.1 - 0.014 15.3 5.2 0.025 14.4 1.9 2.5 2 1 0 2 2 2 0 zf-RING of BARD1-type protein CpXC PF14353.6 KPI83286.1 - 0.059 13.4 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 CpXC protein UBZ_FAAP20 PF15750.5 KPI83286.1 - 0.088 12.8 5.0 0.12 12.4 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Prok-RING_4 PF14447.6 KPI83286.1 - 1.3 8.9 17.3 0.19 11.6 7.7 3.1 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 KPI83286.1 - 5 7.4 10.2 7.9 6.7 7.2 2.7 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 KPI83286.1 - 6.2 6.5 10.2 1.1 8.9 5.1 2.4 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type DnaJ PF00226.31 KPI83287.1 - 1.7e-07 31.3 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4160 PF13711.6 KPI83288.1 - 0.067 13.5 0.4 0.76 10.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) Pkinase PF00069.25 KPI83289.1 - 2.9e-69 233.4 0.0 3.9e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83289.1 - 3.9e-40 137.8 0.0 6.2e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_6 PF13516.6 KPI83289.1 - 1.3e-06 27.9 0.3 0.061 13.4 0.3 3.6 3 0 0 3 3 3 2 Leucine Rich repeat Kinase-like PF14531.6 KPI83289.1 - 6.7e-05 22.3 0.0 0.0001 21.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like LRR_4 PF12799.7 KPI83289.1 - 0.0019 18.6 0.0 0.0082 16.5 0.0 2.1 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) APH PF01636.23 KPI83289.1 - 0.0029 17.6 0.2 1.3 8.9 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KPI83289.1 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI83289.1 - 0.012 15.2 0.3 0.022 14.3 0.0 1.5 2 0 0 2 2 2 0 RIO1 family LRR_8 PF13855.6 KPI83289.1 - 0.017 14.9 0.0 0.42 10.4 0.2 2.5 1 1 0 1 1 1 0 Leucine rich repeat LRR_1 PF00560.33 KPI83289.1 - 0.022 15.3 2.6 7.6 7.5 0.0 3.8 3 1 0 3 3 3 0 Leucine Rich Repeat Arf PF00025.21 KPI83290.1 - 1.7e-68 229.5 0.1 1.9e-68 229.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI83290.1 - 6e-13 49.1 0.0 9.2e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI83290.1 - 2.7e-11 43.2 0.0 3.2e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KPI83290.1 - 1.3e-10 41.0 0.2 6.9e-08 32.0 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KPI83290.1 - 6.6e-10 38.8 0.0 7.9e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KPI83290.1 - 1e-08 34.9 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI83290.1 - 2e-05 24.7 0.0 3.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI83290.1 - 0.019 14.5 0.5 0.092 12.3 0.5 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B HA2 PF04408.23 KPI83292.1 - 2.8e-17 62.9 0.0 8.7e-17 61.4 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI83292.1 - 6.2e-13 49.1 0.0 1.9e-12 47.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain R3H PF01424.22 KPI83292.1 - 4.4e-08 33.0 0.0 1.7e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 R3H domain DEAD PF00270.29 KPI83292.1 - 2e-06 27.7 0.0 4.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI83292.1 - 0.0022 18.3 0.0 0.0091 16.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain Ribosom_S12_S23 PF00164.25 KPI83292.1 - 0.004 16.8 0.4 0.044 13.4 0.0 2.7 3 0 0 3 3 3 1 Ribosomal protein S12/S23 T2SSE PF00437.20 KPI83292.1 - 0.065 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 KPI83292.1 - 0.15 11.5 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein FXMRP1_C_core PF12235.8 KPI83292.1 - 0.63 10.7 7.1 1.9 9.1 7.1 1.8 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Metallophos PF00149.28 KPI83293.1 - 7.3e-13 49.5 0.3 1.1e-12 48.9 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 KPI83293.1 - 0.034 12.4 0.3 0.19 10.0 0.0 2.0 2 0 0 2 2 2 0 Firmicute fructose-1,6-bisphosphatase DUF3053 PF11254.8 KPI83293.1 - 0.059 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) MAM33 PF02330.16 KPI83294.1 - 7.2e-20 71.8 1.0 3.2e-18 66.5 1.0 2.3 1 1 0 1 1 1 1 Mitochondrial glycoprotein TPR_2 PF07719.17 KPI83295.1 - 0.001 19.0 0.5 0.45 10.7 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat PDEase_I_N PF08499.12 KPI83295.1 - 0.031 14.1 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal TPR_14 PF13428.6 KPI83295.1 - 0.39 11.7 1.8 1.3 10.1 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat EF-hand_8 PF13833.6 KPI83296.1 - 2.6e-10 40.0 0.1 5.8e-10 38.9 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 KPI83296.1 - 3.5e-06 27.4 0.0 9.4e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI83296.1 - 0.00026 20.3 0.0 0.0025 17.2 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KPI83296.1 - 0.00041 20.1 0.2 0.0028 17.4 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain MobL PF18555.1 KPI83296.1 - 0.24 10.6 6.6 0.31 10.3 6.6 1.1 1 0 0 1 1 1 0 MobL relaxases RR_TM4-6 PF06459.12 KPI83296.1 - 0.27 11.0 12.2 0.37 10.6 12.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KPI83296.1 - 1.5 7.5 7.7 1.8 7.3 7.7 1.1 1 0 0 1 1 1 0 Presenilin GNAT_acetyltr_2 PF13718.6 KPI83296.1 - 2.2 7.6 4.6 4.4 6.6 4.6 1.5 1 1 0 1 1 1 0 GNAT acetyltransferase 2 eIF-3_zeta PF05091.12 KPI83296.1 - 2.3 7.1 9.7 3.1 6.7 9.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RNA_pol_Rpc4 PF05132.14 KPI83296.1 - 2.9 8.3 7.8 4.8 7.6 7.8 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4407 PF14362.6 KPI83296.1 - 4.2 6.7 10.7 4.4 6.6 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pro_isomerase PF00160.21 KPI83297.1 - 5.8e-36 124.1 0.0 7.2e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lipase_3 PF01764.25 KPI83298.1 - 5.9e-05 23.0 0.0 0.00013 21.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 KPI83298.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 KPI83298.1 - 0.061 13.4 0.1 0.71 9.9 0.0 2.2 2 0 0 2 2 2 0 Thioesterase domain adh_short PF00106.25 KPI83299.1 - 7.5e-20 71.2 0.8 1.5e-17 63.7 0.5 3.0 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI83299.1 - 2e-10 40.7 0.2 7e-09 35.6 0.2 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase YrhK PF14145.6 KPI83299.1 - 1 9.3 3.4 1.9 8.4 0.3 2.3 2 0 0 2 2 2 0 YrhK-like protein A_deaminase PF00962.22 KPI83300.1 - 3.1e-56 191.1 0.0 3.9e-56 190.8 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase adh_short PF00106.25 KPI83301.1 - 1.4e-15 57.2 0.0 4.1e-14 52.5 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI83301.1 - 4.8e-07 29.6 0.0 4.6e-06 26.4 0.0 2.4 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI83301.1 - 0.00011 22.2 1.0 0.0012 18.8 0.3 2.6 3 0 0 3 3 3 1 KR domain 3HCDH_N PF02737.18 KPI83301.1 - 0.01 15.7 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KPI83301.1 - 0.032 13.5 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain MKLP1_Arf_bdg PF16540.5 KPI83302.1 - 0.079 13.0 0.1 7.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Arf6-interacting domain of mitotic kinesin-like protein 1 AMP-binding PF00501.28 KPI83303.1 - 2.2e-17 62.8 0.6 2.1e-06 26.6 0.1 4.1 3 1 0 3 3 3 3 AMP-binding enzyme Mannitol_dh_C PF08125.13 KPI83304.1 - 0.18 11.3 0.0 0.22 11.0 0.0 1.1 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain adh_short PF00106.25 KPI83305.1 - 1.2e-20 73.8 0.1 2.2e-20 73.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI83305.1 - 1.4e-11 44.4 0.2 3.8e-11 43.0 0.2 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI83305.1 - 7.2e-09 35.8 0.1 1.5e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI83305.1 - 3.1e-05 23.5 0.2 5.7e-05 22.7 0.2 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KPI83305.1 - 0.0049 16.3 0.0 0.0069 15.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_7 PF13241.6 KPI83305.1 - 0.0075 16.7 0.1 0.019 15.4 0.1 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 KPI83305.1 - 0.037 13.4 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SAM_MT PF04445.13 KPI83305.1 - 0.053 12.9 0.1 0.082 12.3 0.1 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase THF_DHG_CYH_C PF02882.19 KPI83305.1 - 0.059 12.7 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pyr_redox_2 PF07992.14 KPI83305.1 - 0.096 11.9 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KPI83305.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Zn_Tnp_IS1595 PF12760.7 KPI83305.1 - 0.18 11.8 2.5 0.47 10.5 2.5 1.8 1 0 0 1 1 1 0 Transposase zinc-ribbon domain adh_short PF00106.25 KPI83306.1 - 2.3e-23 82.7 0.0 4.1e-13 49.2 0.0 3.3 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 KPI83306.1 - 2.9e-12 46.6 0.1 7.4e-07 29.0 0.0 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI83306.1 - 3.6e-05 23.7 0.2 9.7e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 KR domain Herpes_capsid PF06112.11 KPI83306.1 - 3.8 7.6 10.7 7.3 6.6 10.7 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein WVELL PF14043.6 KPI83307.1 - 0.043 13.6 0.4 0.084 12.7 0.4 1.5 1 0 0 1 1 1 0 WVELL protein RINGv PF12906.7 KPI83309.1 - 3.2e-13 49.6 6.1 7.4e-13 48.4 5.2 2.1 2 0 0 2 2 2 1 RING-variant domain zf-RING_2 PF13639.6 KPI83309.1 - 0.035 14.4 4.3 0.13 12.7 4.3 2.1 1 0 0 1 1 1 0 Ring finger domain Dus PF01207.17 KPI83310.1 - 1.1e-54 185.7 0.1 4.5e-41 140.9 0.0 3.9 2 2 0 3 3 3 3 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 KPI83310.1 - 0.15 11.2 0.0 0.41 9.8 0.0 1.7 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase Nop25 PF09805.9 KPI83311.1 - 0.086 13.3 7.3 0.64 10.5 0.9 2.3 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Dicty_REP PF05086.12 KPI83311.1 - 0.12 10.4 0.9 0.16 9.9 0.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ANAPC_CDC26 PF10471.9 KPI83311.1 - 6 7.8 16.0 5.5 7.9 5.4 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Pkinase PF00069.25 KPI83312.1 - 4.2e-39 134.5 0.0 8.3e-25 87.6 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83312.1 - 1.7e-14 53.7 0.1 1.7e-07 30.8 0.0 3.3 2 1 0 2 2 2 2 Protein tyrosine kinase RWD PF05773.22 KPI83312.1 - 9e-05 22.7 0.0 0.00046 20.4 0.0 2.2 2 0 0 2 2 2 1 RWD domain NCD1 PF04904.13 KPI83312.1 - 0.0042 17.1 0.0 0.23 11.5 0.0 2.5 2 0 0 2 2 2 1 NAB conserved region 1 (NCD1) PI3K_1B_p101 PF10486.9 KPI83312.1 - 0.0056 14.5 8.2 0.0094 13.8 8.2 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit APH PF01636.23 KPI83312.1 - 0.0066 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YL1 PF05764.13 KPI83312.1 - 0.0099 16.0 4.7 0.016 15.3 4.7 1.3 1 0 0 1 1 1 1 YL1 nuclear protein FTA2 PF13095.6 KPI83312.1 - 0.029 14.0 0.0 0.9 9.1 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Glyco_tranf_2_3 PF13641.6 KPI83312.1 - 0.052 13.4 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Kdo PF06293.14 KPI83312.1 - 0.063 12.6 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SNF2_N PF00176.23 KPI83313.1 - 5.9e-28 97.6 0.0 9.9e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HNH PF01844.23 KPI83313.1 - 5.9e-07 29.6 0.0 5.9e-07 29.6 0.0 3.6 4 0 0 4 4 4 1 HNH endonuclease ResIII PF04851.15 KPI83313.1 - 1.6e-06 28.3 0.0 4.3e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI83313.1 - 3.3e-06 27.4 0.0 1.2e-05 25.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HNH_5 PF14279.6 KPI83313.1 - 0.008 16.0 0.1 0.008 16.0 0.1 2.8 3 1 0 3 3 3 1 HNH endonuclease ABC_tran PF00005.27 KPI83314.1 - 5.7e-28 98.1 0.0 1.5e-27 96.8 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 KPI83314.1 - 0.0041 17.0 1.1 1.3 8.7 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KPI83314.1 - 0.0044 17.4 0.8 0.037 14.4 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 KPI83314.1 - 0.009 15.9 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KPI83314.1 - 0.009 15.7 0.1 0.009 15.7 0.1 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 KPI83314.1 - 0.0098 15.3 0.3 0.13 11.7 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KPI83314.1 - 0.21 12.0 0.1 0.39 11.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KPI83314.1 - 0.22 11.0 0.9 1.5 8.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 KPI83314.1 - 0.32 11.3 1.9 1.5 9.1 0.3 2.5 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Hexapep PF00132.24 KPI83315.1 - 6.5e-14 51.0 4.6 5.9e-05 22.6 0.5 3.3 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KPI83315.1 - 0.11 12.3 11.6 2.2 8.1 1.2 3.8 3 1 1 4 4 4 0 Hexapeptide repeat of succinyl-transferase COPIIcoated_ERV PF07970.12 KPI83316.1 - 1.1e-35 123.5 0.0 2e-35 122.7 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KPI83316.1 - 1.3e-22 80.0 0.1 2.4e-22 79.1 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ATPase-cat_bd PF12156.8 KPI83316.1 - 0.074 13.8 0.5 0.16 12.7 0.5 1.5 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase DUF4307 PF14155.6 KPI83316.1 - 0.14 12.0 0.2 0.27 11.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) PDZ_3 PF17815.1 KPI83317.1 - 0.056 13.3 0.6 12 5.7 0.2 2.3 1 1 0 2 2 2 0 PDZ domain ZapB PF06005.12 KPI83317.1 - 0.12 12.9 5.3 0.78 10.2 0.2 2.9 3 0 0 3 3 3 0 Cell division protein ZapB TMF_DNA_bd PF12329.8 KPI83317.1 - 0.51 10.4 4.1 3.4 7.8 0.1 3.0 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Not1 PF04054.15 KPI83318.1 - 2.9e-93 312.7 9.4 3.3e-93 312.5 8.1 1.8 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 KPI83318.1 - 1.7e-73 246.7 0.5 4.1e-73 245.5 0.3 1.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 KPI83318.1 - 1.8e-43 148.0 0.0 1.8e-41 141.4 0.0 2.6 2 0 0 2 2 2 2 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 KPI83318.1 - 1.5e-20 73.7 0.1 7.1e-20 71.4 0.1 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) Ras PF00071.22 KPI83320.1 - 1.1e-44 152.0 0.0 1.3e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI83320.1 - 4.3e-34 117.3 0.0 5.8e-34 116.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI83320.1 - 1.1e-09 38.0 0.0 1.9e-09 37.2 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KPI83320.1 - 9.1e-06 25.3 0.0 2.3e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KPI83320.1 - 4.7e-05 23.3 0.0 0.017 15.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KPI83320.1 - 0.0011 19.0 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KPI83320.1 - 0.0016 17.9 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KPI83320.1 - 0.039 13.4 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 KPI83320.1 - 0.087 13.1 0.1 0.71 10.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain DUF4509 PF14970.6 KPI83321.1 - 0.74 9.7 6.6 2.5 8.0 2.4 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4509) RNB PF00773.19 KPI83322.1 - 1.7e-50 172.2 0.0 3.7e-50 171.1 0.0 1.5 1 0 0 1 1 1 1 RNB domain Arf PF00025.21 KPI83323.1 - 2.5e-55 186.6 0.0 2.8e-55 186.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KPI83323.1 - 4.8e-16 58.8 0.0 5.5e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI83323.1 - 7.4e-16 58.5 0.0 9.8e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI83323.1 - 4.9e-11 42.4 0.0 6.2e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KPI83323.1 - 2e-09 37.1 0.1 7e-06 25.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KPI83323.1 - 5.3e-09 35.8 0.0 6.8e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI83323.1 - 7.7e-07 29.2 0.0 1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 KPI83323.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 KPI83323.1 - 0.14 11.9 0.2 0.25 11.1 0.1 1.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SERTA PF06031.13 KPI83323.1 - 0.17 11.6 0.7 0.32 10.7 0.7 1.4 1 0 0 1 1 1 0 SERTA motif TniB PF05621.11 KPI83323.1 - 0.19 11.1 0.0 0.53 9.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein zf-MYND PF01753.18 KPI83324.1 - 0.013 15.6 9.4 0.035 14.2 9.4 1.8 1 0 0 1 1 1 0 MYND finger PhyH PF05721.13 KPI83326.1 - 5.8e-36 124.7 0.0 8e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) RRP36 PF06102.12 KPI83327.1 - 1.1e-29 103.5 12.9 2.3e-29 102.5 12.9 1.5 1 1 0 1 1 1 1 rRNA biogenesis protein RRP36 BtrH_N PF14399.6 KPI83327.1 - 0.1 12.9 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal Voltage_CLC PF00654.20 KPI83328.1 - 1.2e-87 294.4 32.2 1e-86 291.4 27.1 2.1 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 KPI83328.1 - 2.2e-07 31.2 4.2 0.0063 16.9 0.2 3.9 4 0 0 4 4 4 2 CBS domain TAT_signal PF10518.9 KPI83328.1 - 0.12 12.3 0.2 0.12 12.3 0.2 4.2 4 0 0 4 4 4 0 TAT (twin-arginine translocation) pathway signal sequence Nop14 PF04147.12 KPI83329.1 - 1.2e-05 23.7 28.8 1.6e-05 23.4 28.8 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 KPI83329.1 - 0.00025 20.6 29.3 0.00031 20.3 29.3 1.1 1 0 0 1 1 1 1 SDA1 Astro_capsid_p PF12226.8 KPI83329.1 - 0.039 13.1 24.2 0.059 12.5 24.2 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PPP4R2 PF09184.11 KPI83329.1 - 0.55 9.8 24.9 0.95 9.0 24.9 1.4 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 KPI83329.1 - 1.5 8.1 36.3 2.3 7.5 36.3 1.2 1 0 0 1 1 1 0 BUD22 DUF4746 PF15928.5 KPI83329.1 - 1.8 7.9 16.1 0.79 9.1 13.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 KPI83329.1 - 7 5.3 10.9 8.8 5.0 10.9 1.2 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 KPI83329.1 - 8.1 5.1 9.5 11 4.7 9.5 1.2 1 0 0 1 1 1 0 Raftlin Nop14 PF04147.12 KPI83330.1 - 0.52 8.4 10.8 0.75 7.9 10.8 1.1 1 0 0 1 1 1 0 Nop14-like family Nudix_N_2 PF14803.6 KPI83331.1 - 2.1 8.3 6.8 7.6 6.6 1.2 3.2 3 0 0 3 3 3 0 Nudix N-terminal ADK PF00406.22 KPI83333.1 - 1.2e-39 135.9 0.0 1.4e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KPI83333.1 - 2.8e-28 99.0 0.0 3.6e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI83333.1 - 4e-06 27.4 0.0 6.7e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI83333.1 - 1.7e-05 25.0 0.0 3.7e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 KPI83333.1 - 0.038 13.6 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 KPI83333.1 - 0.055 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KPI83333.1 - 0.085 12.6 0.1 0.51 10.0 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase SPATIAL PF15256.6 KPI83334.1 - 0.037 14.4 0.1 0.059 13.7 0.1 1.3 1 0 0 1 1 1 0 SPATIAL Vac14_Fig4_bd PF11916.8 KPI83335.1 - 1.6e-41 141.9 2.9 3e-41 141.0 2.9 1.4 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 KPI83335.1 - 3.2e-10 40.4 0.0 5e-09 36.6 0.0 2.6 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KPI83335.1 - 0.054 13.8 4.5 0.078 13.3 0.1 3.7 4 0 0 4 4 4 0 HEAT repeat Utp12 PF04003.12 KPI83335.1 - 1.8 8.9 5.5 3.2 8.1 0.1 3.9 2 1 2 4 4 4 0 Dip2/Utp12 Family MPC PF03650.13 KPI83336.1 - 1e-14 54.6 0.1 1.2e-14 54.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtN3_slv PF03083.16 KPI83336.1 - 0.045 13.8 0.2 0.076 13.1 0.2 1.5 1 1 0 1 1 1 0 Sugar efflux transporter for intercellular exchange Glutaredoxin PF00462.24 KPI83338.1 - 1.5e-07 31.5 0.5 3.3e-07 30.4 0.5 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 KPI83338.1 - 4.3e-07 30.3 0.0 8.2e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KPI83338.1 - 0.0078 16.5 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 KPI83338.1 - 0.018 15.8 0.0 0.034 14.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Syja_N PF02383.18 KPI83339.1 - 5.3e-27 95.0 0.0 7.6e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain LRR_4 PF12799.7 KPI83340.1 - 3.3e-07 30.5 5.8 0.013 15.9 0.0 5.9 2 2 5 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83340.1 - 1.3e-06 28.1 1.1 0.076 12.8 0.1 3.6 4 0 0 4 4 4 2 Leucine rich repeat 3-alpha PF03475.14 KPI83340.1 - 0.047 13.6 0.4 4.2 7.3 0.0 2.9 3 0 0 3 3 3 0 3-alpha domain LRR_6 PF13516.6 KPI83340.1 - 0.06 13.4 2.3 5.8 7.2 0.1 3.8 3 0 0 3 3 3 0 Leucine Rich repeat LRR_5 PF13306.6 KPI83340.1 - 0.16 11.9 0.7 2 8.4 0.1 2.3 1 1 1 2 2 2 0 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KPI83340.1 - 0.88 10.4 4.8 20 6.3 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat PEX11 PF05648.14 KPI83342.1 - 2.8e-10 40.1 3.9 9.3e-09 35.1 3.9 2.4 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Thymopoietin PF08198.11 KPI83342.1 - 0.0025 17.4 0.3 0.016 14.8 0.1 2.2 2 0 0 2 2 2 1 Thymopoietin protein GPHR_N PF12537.8 KPI83342.1 - 0.17 12.0 0.2 0.36 10.9 0.2 1.5 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal PIG-L PF02585.17 KPI83343.1 - 1.8e-23 83.6 0.0 2.3e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase HhH-GPD PF00730.25 KPI83344.1 - 4.5e-22 78.5 0.0 6.5e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein EndIII_4Fe-2S PF10576.9 KPI83344.1 - 0.00044 20.5 6.8 0.00087 19.6 6.8 1.5 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HHH PF00633.23 KPI83344.1 - 0.0019 18.0 0.0 0.0055 16.5 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif Toxin_R_bind_C PF07951.12 KPI83344.1 - 0.0058 16.3 0.0 0.009 15.7 0.0 1.2 1 0 0 1 1 1 1 Clostridium neurotoxin, C-terminal receptor binding DUF3349 PF11829.8 KPI83344.1 - 0.013 16.2 0.0 0.023 15.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) RRM_1 PF00076.22 KPI83345.1 - 5.6e-20 70.9 0.0 7.2e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI83345.1 - 4.9e-05 23.4 0.0 0.0036 17.4 0.0 2.7 1 1 0 2 2 2 1 RNA recognition motif RNA_bind PF08675.11 KPI83345.1 - 0.0089 16.0 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 RNA binding domain HA2 PF04408.23 KPI83346.1 - 8.7e-18 64.6 0.2 3.8e-17 62.5 0.0 2.2 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KPI83346.1 - 3.2e-13 49.9 0.0 7.4e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KPI83346.1 - 4.6e-12 46.3 0.0 1.2e-11 44.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI83346.1 - 7.2e-10 38.9 0.2 3e-09 36.9 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-CCHC PF00098.23 KPI83346.1 - 9.7e-05 22.3 6.6 0.0001 22.2 1.9 2.7 2 0 0 2 2 2 1 Zinc knuckle AAA_19 PF13245.6 KPI83346.1 - 9.9e-05 22.7 0.1 0.00025 21.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain RWD PF05773.22 KPI83346.1 - 0.00013 22.2 0.0 0.00034 20.9 0.0 1.7 1 0 0 1 1 1 1 RWD domain T2SSE PF00437.20 KPI83346.1 - 0.00018 20.7 0.0 0.00034 19.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 KPI83346.1 - 0.0005 20.3 0.7 0.0045 17.3 0.3 2.8 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI83346.1 - 0.039 13.7 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KPI83346.1 - 0.06 12.7 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_11 PF13086.6 KPI83346.1 - 0.086 12.6 0.6 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain PcfK PF14058.6 KPI83346.1 - 0.13 12.5 0.2 0.89 9.8 0.0 2.4 3 0 0 3 3 2 0 PcfK-like protein AAA_23 PF13476.6 KPI83346.1 - 0.22 12.0 2.1 0.29 11.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain RRM_1 PF00076.22 KPI83347.1 - 1.5e-15 56.8 0.0 2.2e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI83347.1 - 0.0027 17.3 0.0 0.0051 16.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI83347.1 - 0.036 14.2 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif Pex14_N PF04695.13 KPI83347.1 - 7.4 7.2 9.1 6.5 7.4 8.0 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_C14 PF00656.22 KPI83348.1 - 3.2e-54 184.5 0.0 4.1e-54 184.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 KPI83348.1 - 0.15 12.0 0.0 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain tRNA-synt_1e PF01406.19 KPI83349.1 - 1.1e-113 379.6 0.0 1.6e-113 379.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KPI83349.1 - 0.00055 18.8 0.5 0.0077 15.0 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KPI83349.1 - 0.0034 15.7 0.9 0.35 9.1 0.0 3.0 4 0 0 4 4 4 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 KPI83349.1 - 0.043 12.7 0.0 0.17 10.7 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain LPD22 PF18834.1 KPI83349.1 - 7.1 6.9 12.2 0.3 11.3 2.6 2.9 3 1 1 4 4 4 0 Large polyvalent protein associated domain 22 HAGH_C PF16123.5 KPI83352.1 - 1.4e-07 31.9 0.0 2.8e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KPI83352.1 - 0.00068 19.7 7.2 0.0023 18.0 7.2 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KPI83352.1 - 0.027 14.0 0.4 0.055 13.0 0.4 1.6 1 0 0 1 1 1 0 Beta-lactamase superfamily domain AAA PF00004.29 KPI83353.1 - 2.7e-45 154.0 0.0 7.9e-45 152.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI83353.1 - 2.7e-09 36.7 0.0 5.9e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KPI83353.1 - 7.1e-09 35.5 0.2 3.2e-08 33.4 0.0 2.2 3 0 0 3 3 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 KPI83353.1 - 1.8e-08 34.5 0.1 9.7e-08 32.1 0.1 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI83353.1 - 1.8e-07 31.7 0.2 2.6e-05 24.7 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KPI83353.1 - 6.6e-07 29.6 0.1 3e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KPI83353.1 - 3.7e-05 24.0 1.6 0.009 16.3 0.8 3.2 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 KPI83353.1 - 5.3e-05 22.5 0.0 9.9e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KPI83353.1 - 0.00036 20.3 0.0 0.00099 18.9 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KPI83353.1 - 0.00042 20.6 0.0 0.00079 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KPI83353.1 - 0.00053 19.5 0.0 0.0022 17.5 0.0 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 KPI83353.1 - 0.0012 18.8 0.6 0.031 14.2 0.0 3.1 3 1 1 4 4 4 1 NACHT domain AAA_33 PF13671.6 KPI83353.1 - 0.0013 18.9 0.0 0.0061 16.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 KPI83353.1 - 0.0014 18.5 0.4 0.0072 16.2 0.1 2.4 4 0 0 4 4 3 1 NTPase AAA_18 PF13238.6 KPI83353.1 - 0.0016 19.0 0.0 0.0039 17.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI83353.1 - 0.0017 18.1 0.1 0.0048 16.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 KPI83353.1 - 0.0023 17.8 0.2 0.011 15.6 0.0 2.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KPI83353.1 - 0.0026 17.8 0.0 0.0089 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 KPI83353.1 - 0.0049 16.3 0.1 0.48 9.8 0.0 2.8 3 0 0 3 3 3 1 Bacterial TniB protein Mg_chelatase PF01078.21 KPI83353.1 - 0.0067 15.8 0.1 0.019 14.4 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 KPI83353.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EzrA PF06160.12 KPI83353.1 - 0.012 13.9 1.7 0.017 13.3 1.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TIP49 PF06068.13 KPI83353.1 - 0.012 14.8 0.1 0.037 13.2 0.0 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 KPI83353.1 - 0.017 15.1 0.1 0.14 12.1 0.1 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KPI83353.1 - 0.017 14.8 0.0 0.038 13.7 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 KPI83353.1 - 0.019 14.7 0.4 0.6 9.8 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_24 PF13479.6 KPI83353.1 - 0.019 14.7 0.2 0.047 13.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KPI83353.1 - 0.021 15.2 0.0 0.06 13.7 0.0 1.8 2 0 0 2 2 1 0 RNA helicase ATPase PF06745.13 KPI83353.1 - 0.021 14.2 1.0 0.96 8.8 0.0 2.9 3 0 0 3 3 3 0 KaiC AAA_19 PF13245.6 KPI83353.1 - 0.024 15.0 0.2 0.077 13.3 0.1 1.8 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.6 KPI83353.1 - 0.027 14.2 0.4 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 KPI83353.1 - 0.032 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein cobW PF02492.19 KPI83353.1 - 0.054 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 KPI83353.1 - 0.075 13.5 0.2 0.3 11.6 0.0 2.3 2 2 0 2 2 2 0 ABC transporter AAA_25 PF13481.6 KPI83353.1 - 0.078 12.6 0.9 0.39 10.3 0.1 2.2 1 1 0 2 2 2 0 AAA domain Glyco_hydr_30_2 PF14587.6 KPI83353.1 - 0.11 12.1 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 O-Glycosyl hydrolase family 30 DEAD PF00270.29 KPI83354.1 - 6.2e-20 71.7 0.0 4.9e-19 68.8 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 KPI83354.1 - 1.9e-08 34.5 0.0 4.8e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI83354.1 - 0.0003 21.1 0.1 0.0008 19.7 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Beta_helix PF13229.6 KPI83355.1 - 1.1e-05 25.3 0.2 18 5.1 0.1 5.2 5 0 0 5 5 5 4 Right handed beta helix region tRNA_edit PF04073.15 KPI83356.1 - 2e-21 76.4 0.1 4.9e-21 75.1 0.1 1.6 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain Herpes_LMP1 PF05297.11 KPI83357.1 - 0.036 13.3 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) TMEM132D_C PF15706.5 KPI83358.1 - 0.025 14.4 2.2 0.035 13.9 2.2 1.4 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Adeno_E3_CR2 PF02439.15 KPI83358.1 - 0.074 12.8 5.9 0.18 11.6 5.9 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DHODB_Fe-S_bind PF10418.9 KPI83359.1 - 0.43 10.4 5.1 1.2 9.0 0.6 3.0 3 0 0 3 3 3 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B OAD_gamma PF04277.13 KPI83360.1 - 0.058 14.0 0.3 0.12 13.0 0.3 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain GRP PF07172.11 KPI83361.1 - 0.0025 18.5 5.8 0.084 13.6 0.2 2.2 2 0 0 2 2 2 2 Glycine rich protein family WBP-1 PF11669.8 KPI83361.1 - 0.029 15.0 0.4 0.066 13.9 0.1 1.9 1 1 1 2 2 2 0 WW domain-binding protein 1 Shisa PF13908.6 KPI83361.1 - 0.72 10.1 5.1 0.45 10.7 0.1 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF3301 PF11743.8 KPI83362.1 - 0.05 13.3 0.6 0.14 11.8 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) Peptidase_M20 PF01546.28 KPI83364.1 - 2.5e-22 79.6 0.1 3.2e-22 79.3 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI83364.1 - 1.1e-07 31.7 0.0 2.2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Pkinase PF00069.25 KPI83365.1 - 4.2e-74 249.3 0.0 4.8e-74 249.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83365.1 - 6.3e-34 117.4 0.0 7.9e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI83365.1 - 0.00092 19.2 0.7 0.014 15.3 0.4 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI83365.1 - 0.0018 17.7 0.0 0.038 13.3 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 KPI83365.1 - 0.0085 15.5 0.6 0.018 14.4 0.6 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI83365.1 - 0.084 11.8 0.0 10 4.9 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain Cpn60_TCP1 PF00118.24 KPI83366.1 - 6.6e-141 470.3 9.3 8.1e-141 470.0 9.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Colicin PF01024.19 KPI83366.1 - 0.00047 20.1 0.1 0.0023 17.8 0.2 2.0 2 0 0 2 2 2 1 Colicin pore forming domain Cwf_Cwc_15 PF04889.12 KPI83369.1 - 1.4e-05 24.9 19.6 4.2e-05 23.4 19.7 1.8 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.12 KPI83369.1 - 0.31 9.6 16.7 0.36 9.4 16.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LTXXQ PF07813.12 KPI83369.1 - 0.34 11.6 5.5 0.083 13.6 1.8 1.9 2 0 0 2 2 2 0 LTXXQ motif family protein ABC1 PF03109.16 KPI83370.1 - 1.4e-28 99.4 0.0 3.1e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 KPI83370.1 - 0.0073 15.9 0.0 0.026 14.1 0.0 1.9 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 KPI83370.1 - 0.015 14.7 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain APH PF01636.23 KPI83370.1 - 0.018 15.0 0.2 1.2 9.0 0.0 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 KPI83370.1 - 0.024 13.9 0.0 1.9 7.7 0.0 2.9 3 0 0 3 3 3 0 Protein tyrosine kinase PG_binding_1 PF01471.18 KPI83370.1 - 0.078 13.2 1.1 0.19 11.9 0.1 2.1 2 1 0 2 2 2 0 Putative peptidoglycan binding domain Exo_endo_phos_2 PF14529.6 KPI83371.1 - 1.2e-15 57.4 0.1 1.9e-15 56.7 0.1 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 KPI83371.1 - 3.7e-07 29.9 3.6 8.7e-07 28.7 1.8 2.3 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family ABATE PF07336.11 KPI83371.1 - 0.14 12.8 3.9 0.43 11.2 3.9 1.8 1 0 0 1 1 1 0 Putative stress-induced transcription regulator Ribosomal_S17e PF00833.18 KPI83371.1 - 0.19 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S17 Peptidase_M20 PF01546.28 KPI83372.1 - 2.3e-18 66.7 0.0 3.1e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI83372.1 - 1.9e-07 31.0 0.0 3.1e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain AP_endonuc_2 PF01261.24 KPI83372.1 - 0.15 11.5 0.0 0.54 9.7 0.0 1.9 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel adh_short PF00106.25 KPI83374.1 - 1e-31 109.9 0.0 1.4e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI83374.1 - 3.4e-22 79.2 0.0 4.7e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI83374.1 - 7.6e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI83374.1 - 0.06 12.8 0.1 0.086 12.3 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 KPI83374.1 - 0.06 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribul_P_3_epim PF00834.19 KPI83377.1 - 5.1e-57 192.5 0.0 6.1e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family TauE PF01925.19 KPI83378.1 - 7.4e-14 52.0 16.1 6.3e-09 35.8 3.4 2.3 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE Vpu PF00558.19 KPI83378.1 - 0.044 13.6 1.3 0.78 9.6 0.1 2.5 2 0 0 2 2 2 0 Vpu protein NicO PF03824.16 KPI83378.1 - 0.057 12.8 8.0 0.31 10.3 0.1 2.9 3 0 0 3 3 3 0 High-affinity nickel-transport protein GRIM-19 PF06212.12 KPI83378.1 - 0.15 12.0 0.2 0.7 9.8 0.1 2.2 2 0 0 2 2 2 0 GRIM-19 protein RseC_MucC PF04246.12 KPI83378.1 - 1.2 9.0 5.4 0.91 9.5 0.6 2.6 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC zf_C2H2_10 PF18414.1 KPI83380.1 - 0.01 15.3 0.2 0.016 14.7 0.2 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger zf_C2H2_ZHX PF18387.1 KPI83380.1 - 0.029 14.0 0.3 0.056 13.1 0.3 1.5 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain Lipase_3 PF01764.25 KPI83381.1 - 0.079 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) PIH1_CS PF18201.1 KPI83382.1 - 1e-06 29.1 0.0 1.6e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain Keratin_matx PF04579.12 KPI83382.1 - 0.011 16.1 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 Keratin, high-sulphur matrix protein TolA_bind_tri PF16331.5 KPI83383.1 - 0.014 15.5 1.6 0.014 15.5 1.6 4.9 2 1 2 4 4 3 0 TolA binding protein trimerisation DUF4715 PF15835.5 KPI83383.1 - 0.1 12.7 7.4 0.14 12.3 6.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4715) NPV_P10 PF05531.12 KPI83383.1 - 0.81 10.2 13.7 14 6.2 5.8 4.2 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Phasin PF05597.11 KPI83383.1 - 2.4 8.2 23.2 1.3 9.1 5.8 2.9 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Snapin_Pallidin PF14712.6 KPI83383.1 - 3.3 8.2 27.9 2.5 8.6 0.4 4.8 1 1 1 3 3 3 0 Snapin/Pallidin Exonuc_VII_L PF02601.15 KPI83383.1 - 3.5 7.1 29.4 1.9e+02 1.4 29.4 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 KPI83383.1 - 3.8 7.6 22.7 0.051 13.6 3.7 3.3 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 KPI83383.1 - 4.7 5.0 16.4 5.9 4.7 16.0 1.3 1 1 0 1 1 1 0 Prominin KIP1 PF07765.12 KPI83383.1 - 6 7.1 10.4 1 9.5 0.4 3.5 1 1 2 3 3 3 0 KIP1-like protein LMBR1 PF04791.16 KPI83383.1 - 6.7 5.5 9.4 8.4 5.2 9.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ERp29 PF07749.12 KPI83383.1 - 7.2 7.6 13.6 0.53 11.2 1.9 3.9 1 1 2 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain YtxH PF12732.7 KPI83383.1 - 9 6.9 8.5 20 5.8 0.4 3.3 2 1 0 2 2 2 0 YtxH-like protein EDR1 PF14381.6 KPI83383.1 - 9.9 5.8 10.9 13 5.5 5.5 2.6 1 1 2 3 3 3 0 Ethylene-responsive protein kinase Le-CTR1 Pyr_redox_2 PF07992.14 KPI83384.1 - 4.6e-46 157.4 0.3 6.8e-46 156.8 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KPI83384.1 - 3.1e-20 72.5 0.1 1.1e-19 70.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KPI83384.1 - 8.3e-18 64.7 4.6 2.6e-16 59.9 0.0 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KPI83384.1 - 1.9e-09 37.4 0.3 4.4e-09 36.2 0.3 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KPI83384.1 - 2.5e-08 33.5 9.6 0.00061 19.1 1.6 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI83384.1 - 1.7e-07 30.3 3.6 0.00016 20.5 0.6 3.2 3 0 0 3 3 3 2 HI0933-like protein K_oxygenase PF13434.6 KPI83384.1 - 3.7e-07 29.6 0.1 8.6e-06 25.1 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 KPI83384.1 - 2.7e-06 27.2 9.0 0.0068 16.0 1.4 3.2 2 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KPI83384.1 - 4.8e-06 26.1 0.0 0.0051 16.1 0.0 3.1 3 0 0 3 3 3 1 FAD binding domain FAD_binding_2 PF00890.24 KPI83384.1 - 2.5e-05 23.6 5.5 0.00016 20.9 1.0 2.9 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 KPI83384.1 - 3.5e-05 23.2 0.3 0.01 15.1 0.1 2.4 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 KPI83384.1 - 7.6e-05 22.0 7.2 0.23 10.5 6.1 3.3 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 KPI83384.1 - 0.00018 21.7 1.2 0.2 11.9 0.5 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 KPI83384.1 - 0.00024 20.5 0.0 0.6 9.4 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 KPI83384.1 - 0.0015 18.4 0.0 0.0049 16.8 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 KPI83384.1 - 0.0019 17.3 0.2 0.17 10.9 0.2 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein ThiF PF00899.21 KPI83384.1 - 0.0044 16.4 0.0 0.0092 15.4 0.0 1.5 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 KPI83384.1 - 0.051 12.9 0.0 0.29 10.5 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RNA_pol_Rpb1_2 PF00623.20 KPI83384.1 - 0.08 13.2 0.1 0.47 10.6 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 2 NAD_binding_7 PF13241.6 KPI83384.1 - 0.099 13.1 0.1 13 6.3 0.1 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 KPI83384.1 - 0.18 12.0 1.3 0.84 9.9 0.1 2.7 3 0 0 3 3 2 0 TrkA-N domain Trp_halogenase PF04820.14 KPI83384.1 - 2 7.2 3.7 12 4.6 0.6 2.8 4 0 0 4 4 4 0 Tryptophan halogenase Bac_surface_Ag PF01103.23 KPI83385.1 - 1.2e-17 64.5 0.2 1.5e-17 64.1 0.2 1.2 1 0 0 1 1 1 1 Surface antigen Folliculin PF11704.8 KPI83386.1 - 1.7e-08 34.6 0.1 3.8e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport Folliculin_C PF16692.5 KPI83386.1 - 2.7e-06 27.3 0.0 5.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Folliculin C-terminal domain Pox_MCEL PF03291.16 KPI83387.1 - 2.6e-43 148.4 0.0 3.4e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme mRNA_cap_C PF03919.15 KPI83387.1 - 4.7e-08 33.6 0.0 1e-07 32.5 0.0 1.6 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain mRNA_cap_enzyme PF01331.19 KPI83387.1 - 4.6e-07 29.9 0.0 0.009 15.8 0.0 3.2 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain Methyltransf_25 PF13649.6 KPI83387.1 - 0.00015 22.4 0.1 0.0017 19.0 0.1 2.9 1 1 1 2 2 2 1 Methyltransferase domain DNA_ligase_A_M PF01068.21 KPI83387.1 - 0.034 13.8 0.0 0.17 11.5 0.0 2.1 2 0 0 2 2 2 0 ATP dependent DNA ligase domain DnaJ_C PF01556.18 KPI83388.1 - 6.4e-34 117.2 0.1 8.8e-34 116.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KPI83388.1 - 7.7e-15 55.0 16.7 1.9e-14 53.8 16.7 1.7 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI83388.1 - 1.7e-06 27.9 14.0 0.0047 16.9 5.8 2.4 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KPI83388.1 - 0.0012 18.8 8.1 0.065 13.3 0.7 2.6 1 1 1 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 KPI83388.1 - 0.021 14.5 3.0 0.037 13.7 3.0 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 ZZ PF00569.17 KPI83388.1 - 0.084 12.7 0.6 0.084 12.7 0.6 2.4 3 0 0 3 3 3 0 Zinc finger, ZZ type FdhE PF04216.12 KPI83388.1 - 0.66 9.8 4.6 1.3 8.9 4.6 1.4 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-CHY PF05495.12 KPI83388.1 - 3.1 8.4 6.1 26 5.4 0.2 2.3 1 1 1 2 2 2 0 CHY zinc finger DZR PF12773.7 KPI83388.1 - 4.2 7.5 9.4 33 4.6 9.4 2.3 1 1 0 1 1 1 0 Double zinc ribbon DUF3701 PF12482.8 KPI83389.1 - 0.035 14.2 0.0 0.082 13.0 0.0 1.7 1 0 0 1 1 1 0 Phage integrase protein DUF1056 PF06341.11 KPI83389.1 - 0.16 12.3 0.1 0.31 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1056) R3H PF01424.22 KPI83390.1 - 1.5e-12 47.3 0.0 2.8e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 KPI83390.1 - 2.6e-10 40.2 64.9 7.7e-06 25.9 14.0 14.3 15 2 1 16 16 16 8 NF-X1 type zinc finger SET PF00856.28 KPI83392.1 - 0.00067 20.1 0.0 0.0015 19.0 0.0 1.7 1 1 0 1 1 1 1 SET domain Ribosomal_L5_C PF00673.21 KPI83393.1 - 4.5e-21 74.8 0.0 7.2e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KPI83393.1 - 5.6e-18 65.0 0.2 1.1e-16 60.8 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L5 WD40 PF00400.32 KPI83396.1 - 3.1e-11 43.7 3.8 0.089 13.7 0.0 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 KPI83396.1 - 0.0037 16.0 0.0 0.081 11.5 0.0 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 TPR_MalT PF17874.1 KPI83396.1 - 0.018 14.4 0.1 0.03 13.7 0.1 1.2 1 0 0 1 1 1 0 MalT-like TPR region CLTH PF10607.9 KPI83396.1 - 0.079 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain PQQ PF01011.21 KPI83396.1 - 0.51 10.4 2.2 1.6 8.8 0.1 2.7 3 0 0 3 3 3 0 PQQ enzyme repeat Prenyltransf PF01255.19 KPI83397.1 - 1.8e-55 187.9 0.1 1.3e-52 178.6 0.0 2.1 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase DUF3086 PF11285.8 KPI83398.1 - 0.0011 18.1 0.4 0.0014 17.8 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3086) SesA PF17107.5 KPI83398.1 - 0.025 14.8 0.8 0.04 14.1 0.8 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Atg14 PF10186.9 KPI83398.1 - 0.03 13.4 1.1 0.039 13.1 1.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SKA2 PF16740.5 KPI83398.1 - 0.078 12.8 1.3 0.31 10.8 0.1 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 MnmE_helical PF12631.7 KPI83398.1 - 0.12 12.5 0.4 0.2 11.8 0.4 1.3 1 0 0 1 1 1 0 MnmE helical domain CLZ PF16526.5 KPI83398.1 - 0.65 10.4 4.8 0.78 10.1 3.5 1.7 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Se-cys_synth_N PF12390.8 KPI83399.1 - 0.26 11.5 2.9 0.34 11.2 0.2 2.6 3 0 0 3 3 3 0 Selenocysteine synthase N terminal MerR-DNA-bind PF09278.11 KPI83399.1 - 8.2 7.0 11.9 4.5 7.9 2.2 2.8 2 0 0 2 2 2 0 MerR, DNA binding RNase_HII PF01351.18 KPI83400.1 - 9e-26 90.9 0.0 5e-24 85.2 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease HII DNA_pol_A PF00476.20 KPI83403.1 - 1.1e-32 113.6 0.0 3.8e-32 111.8 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase family A RNase_T PF00929.24 KPI83403.1 - 3.3e-17 63.5 0.0 8.2e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 Exonuclease Adaptin_N PF01602.20 KPI83404.1 - 2.3e-84 283.8 6.6 2.9e-84 283.5 6.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KPI83404.1 - 0.00055 20.0 3.6 0.046 13.8 0.0 3.1 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Nipped-B_C PF12830.7 KPI83404.1 - 0.0071 16.3 0.9 0.038 13.9 0.1 2.5 3 0 0 3 3 3 1 Sister chromatid cohesion C-terminus Med29 PF11568.8 KPI83404.1 - 0.083 13.1 0.4 5.9 7.1 0.0 2.5 2 0 0 2 2 2 0 Mediator complex subunit 29 HEAT PF02985.22 KPI83404.1 - 0.086 13.1 0.0 14 6.2 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat DUF3663 PF12404.8 KPI83405.1 - 0.057 13.5 0.5 0.12 12.4 0.1 1.7 2 0 0 2 2 2 0 Peptidase Peptidase_M20 PF01546.28 KPI83406.1 - 3.5e-32 111.8 0.0 5.4e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI83406.1 - 7.8e-21 74.0 0.0 1.3e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KPI83406.1 - 0.0045 16.7 0.0 0.0079 15.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 KPI83406.1 - 0.02 13.9 0.0 0.14 11.2 0.0 2.3 2 1 0 2 2 2 0 M42 glutamyl aminopeptidase DOT1 PF08123.13 KPI83407.1 - 5.1e-21 75.1 0.0 1e-20 74.2 0.0 1.4 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 KPI83407.1 - 2.4e-06 27.4 0.0 3.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI83407.1 - 7.4e-05 23.4 0.0 0.00014 22.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KPI83407.1 - 0.00023 20.5 0.0 0.00038 19.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 KPI83407.1 - 0.00036 21.1 0.0 0.00076 20.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KPI83407.1 - 0.00045 20.3 0.0 0.00082 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI83407.1 - 0.00085 18.9 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KPI83407.1 - 0.0039 17.0 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI83407.1 - 0.011 16.4 0.0 0.02 15.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 KPI83407.1 - 0.031 14.6 0.0 0.054 13.8 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_4 PF02390.17 KPI83407.1 - 0.044 13.2 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase MetW PF07021.12 KPI83407.1 - 0.048 13.2 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF4268 PF14088.6 KPI83407.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4268) PCMT PF01135.19 KPI83407.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 KPI83407.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PrmA PF06325.13 KPI83407.1 - 0.16 11.4 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Isy1 PF06246.12 KPI83408.1 - 7.4e-27 94.5 12.6 4.2e-26 92.1 12.6 2.1 1 1 0 1 1 1 1 Isy1-like splicing family ThiF PF00899.21 KPI83409.1 - 6.6e-42 143.5 0.1 1.1e-41 142.8 0.1 1.3 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 KPI83409.1 - 1.4e-24 87.3 0.0 5.3e-24 85.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Shikimate_DH PF01488.20 KPI83409.1 - 4.4e-05 23.6 0.0 0.0031 17.6 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 KPI83409.1 - 0.071 12.5 0.0 13 5.1 0.0 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Selenoprotein_S PF06936.11 KPI83411.1 - 0.3 10.9 12.1 0.89 9.3 12.1 1.8 1 0 0 1 1 1 0 Selenoprotein S (SelS) TAP42 PF04177.12 KPI83411.1 - 2.8 7.0 10.6 5.7 6.0 10.6 1.4 1 0 0 1 1 1 0 TAP42-like family SNF2_N PF00176.23 KPI83412.1 - 8.4e-54 182.6 1.6 8.3e-22 77.4 1.2 3.5 3 1 0 3 3 3 3 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI83412.1 - 2.2e-17 63.4 0.0 1.2e-16 61.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-PARP PF00645.18 KPI83412.1 - 1.2e-09 38.9 0.7 1.2e-09 38.9 0.7 2.3 2 0 0 2 2 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-RING_2 PF13639.6 KPI83412.1 - 7e-07 29.5 3.7 7e-07 29.5 3.7 2.4 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI83412.1 - 1.6e-05 24.7 5.0 5.4e-05 23.0 5.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI83412.1 - 5.1e-05 23.1 3.1 5.1e-05 23.1 3.1 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KPI83412.1 - 9.8e-05 22.0 1.7 0.00025 20.7 1.7 1.8 1 0 0 1 1 1 1 RING-like zinc finger ERCC3_RAD25_C PF16203.5 KPI83412.1 - 0.00011 21.5 0.0 0.00026 20.3 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-rbx1 PF12678.7 KPI83412.1 - 0.00084 19.6 3.1 0.0027 18.0 3.1 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain PHD PF00628.29 KPI83412.1 - 0.0015 18.4 2.4 0.0015 18.4 2.4 3.8 5 0 0 5 5 4 1 PHD-finger zf-RING_5 PF14634.6 KPI83412.1 - 0.0044 16.9 4.1 0.0044 16.9 4.1 3.6 4 0 0 4 4 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KPI83412.1 - 0.005 16.8 3.2 0.018 15.1 3.2 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KPI83412.1 - 0.0067 16.4 1.3 0.025 14.6 1.3 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger ResIII PF04851.15 KPI83412.1 - 0.017 15.1 0.0 5.6 6.9 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit zinc_ribbon_4 PF13717.6 KPI83412.1 - 0.86 9.6 7.3 1e+02 2.9 0.1 4.5 4 0 0 4 4 4 0 zinc-ribbon domain PP2C PF00481.21 KPI83413.1 - 4.2e-51 174.0 0.0 5.7e-51 173.6 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KPI83413.1 - 0.0029 17.6 0.0 0.016 15.1 0.0 2.0 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KPI83413.1 - 0.0031 17.2 0.0 0.011 15.4 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C Luciferase_N PF05295.11 KPI83413.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain DUF3665 PF12427.8 KPI83414.1 - 0.0089 15.7 0.2 1.1 9.0 0.0 2.5 2 0 0 2 2 2 2 Branched-chain amino acid aminotransferase Atx10homo_assoc PF09759.9 KPI83415.1 - 0.19 11.8 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain GRP PF07172.11 KPI83416.1 - 0.00022 21.9 2.5 0.00022 21.9 2.5 1.8 1 1 0 2 2 2 1 Glycine rich protein family Ras PF00071.22 KPI83417.1 - 1.3e-54 184.1 0.1 1.6e-54 183.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI83417.1 - 4.1e-37 127.1 0.0 5.9e-37 126.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI83417.1 - 2.6e-15 56.3 0.0 3.3e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI83417.1 - 1.4e-05 24.6 0.1 1.8e-05 24.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KPI83417.1 - 3.1e-05 23.6 0.1 0.00011 21.8 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI83417.1 - 0.00042 20.4 0.0 0.0031 17.6 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KPI83417.1 - 0.0011 18.4 0.0 0.0026 17.2 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 KPI83417.1 - 0.0011 18.8 0.0 0.0023 17.8 0.0 1.5 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 KPI83417.1 - 0.0018 18.2 0.0 0.3 11.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 KPI83417.1 - 0.016 14.8 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 KPI83417.1 - 0.038 13.4 0.0 0.11 11.9 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 KPI83417.1 - 0.058 13.1 0.1 5.1 6.8 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KPI83417.1 - 0.067 12.7 0.1 4.9 6.7 0.1 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 KPI83417.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain GlcNAc PF11397.8 KPI83418.1 - 1.5e-05 24.6 0.3 0.012 15.1 0.0 2.8 2 1 0 2 2 2 2 Glycosyltransferase (GlcNAc) GlcNAc PF11397.8 KPI83419.1 - 7e-121 404.0 0.0 9.1e-121 403.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) TMEM171 PF15471.6 KPI83419.1 - 0.076 12.0 0.3 0.13 11.2 0.3 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 DUF3724 PF12521.8 KPI83419.1 - 0.12 12.3 1.1 0.4 10.7 1.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) DUF5583 PF17821.1 KPI83420.1 - 0.49 10.4 3.1 1.6 8.7 0.3 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5583) CpXC PF14353.6 KPI83423.1 - 0.00012 22.1 0.2 0.00023 21.2 0.2 1.4 1 0 0 1 1 1 1 CpXC protein zf-C2H2_4 PF13894.6 KPI83423.1 - 0.0051 17.5 3.1 0.014 16.2 3.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger DivIC PF04977.15 KPI83423.1 - 0.022 14.5 0.6 0.05 13.4 0.6 1.5 1 0 0 1 1 1 0 Septum formation initiator GIT_CC PF16559.5 KPI83423.1 - 0.028 14.3 0.3 0.048 13.5 0.3 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf_UBZ PF18439.1 KPI83423.1 - 0.046 13.3 0.3 0.079 12.6 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger ZapB PF06005.12 KPI83423.1 - 0.064 13.7 1.3 0.11 13.0 1.3 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF2205 PF10224.9 KPI83423.1 - 0.076 13.0 0.6 0.13 12.2 0.6 1.3 1 0 0 1 1 1 0 Short coiled-coil protein Mito_fiss_reg PF05308.11 KPI83423.1 - 0.75 9.8 4.1 0.57 10.2 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator Ion_trans_2 PF07885.16 KPI83424.1 - 8.4e-12 44.9 4.5 8.4e-12 44.9 4.5 2.4 3 0 0 3 3 3 1 Ion channel BK_channel_a PF03493.18 KPI83424.1 - 2.4e-11 43.7 0.0 6.9e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Hamartin PF04388.12 KPI83424.1 - 0.28 9.8 7.5 0.42 9.2 7.5 1.1 1 0 0 1 1 1 0 Hamartin protein Rtf2 PF04641.12 KPI83424.1 - 1.1 8.5 3.8 2.4 7.5 3.8 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger Ion_trans_2 PF07885.16 KPI83425.1 - 8.1e-12 44.9 3.9 1.9e-11 43.8 3.9 1.6 1 0 0 1 1 1 1 Ion channel BK_channel_a PF03493.18 KPI83425.1 - 8.5e-07 29.1 0.0 2.2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Lipase_GDSL PF00657.22 KPI83426.1 - 7.2e-07 29.4 0.0 8.6e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 KPI83426.1 - 1.7e-06 28.6 0.1 3.3e-06 27.6 0.1 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Snf7 PF03357.21 KPI83428.1 - 1.6e-38 132.0 18.4 1.9e-38 131.8 18.4 1.0 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 KPI83428.1 - 0.0038 17.7 7.5 0.0052 17.2 3.9 2.5 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein DUF4392 PF14336.6 KPI83428.1 - 0.071 12.5 3.2 0.096 12.1 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) XRN_M PF17846.1 KPI83428.1 - 0.087 11.8 8.0 0.12 11.3 8.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Exonuc_VII_L PF02601.15 KPI83428.1 - 0.14 11.7 6.4 0.16 11.5 6.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3573 PF12097.8 KPI83428.1 - 2.4 6.9 5.2 3.1 6.5 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Activator_LAG-3 PF11498.8 KPI83428.1 - 6.4 5.6 23.0 7.9 5.3 23.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 WD40 PF00400.32 KPI83429.1 - 0.00012 22.8 10.7 0.16 12.9 1.0 5.5 4 0 0 4 4 4 2 WD domain, G-beta repeat PIP5K PF01504.18 KPI83430.1 - 3.9e-57 193.6 0.0 1.4e-56 191.8 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PDZ PF00595.24 KPI83432.1 - 0.045 14.1 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain KIF1B PF12423.8 KPI83432.1 - 0.18 12.3 1.7 0.52 10.8 0.0 2.6 2 0 0 2 2 2 0 Kinesin protein 1B SOAR PF16533.5 KPI83432.1 - 8.4 6.4 11.6 5.9 6.9 0.4 2.8 2 0 0 2 2 2 0 STIM1 Orai1-activating region DnaJ PF00226.31 KPI83433.1 - 7.8e-14 51.6 0.0 1.5e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain zf-C3HC4_3 PF13920.6 KPI83433.1 - 0.0014 18.5 5.2 0.0026 17.6 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RR_TM4-6 PF06459.12 KPI83433.1 - 1.4 8.7 9.8 0.029 14.2 2.1 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Ribonuclease PF00545.20 KPI83435.1 - 0.026 15.2 0.2 0.072 13.8 0.2 1.7 1 1 0 1 1 1 0 ribonuclease Protoglobin PF11563.8 KPI83436.1 - 0.49 10.3 1.8 3.7 7.4 0.3 2.3 2 0 0 2 2 2 0 Protoglobin HTH_Mga PF08280.11 KPI83437.1 - 0.019 15.0 0.2 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain Serinc PF03348.15 KPI83438.1 - 1.1e-56 192.6 35.2 6.3e-56 190.1 35.2 1.8 1 1 0 1 1 1 1 Serine incorporator (Serinc) DUF1648 PF07853.11 KPI83439.1 - 3.7e-07 29.7 2.0 8.5e-07 28.5 2.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1648) Vps39_2 PF10367.9 KPI83440.1 - 4.9e-15 55.9 0.0 9.9e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 KPI83440.1 - 0.0068 16.3 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Region in Clathrin and VPS LSM PF01423.22 KPI83442.1 - 0.0027 17.4 0.1 0.0041 16.8 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KPI83442.1 - 0.073 13.2 0.1 0.18 12.0 0.1 1.7 1 1 1 2 2 2 0 Ataxin 2 SM domain Skp1 PF01466.19 KPI83443.1 - 4.1e-05 23.6 0.5 4.1e-05 23.6 0.5 2.5 3 0 0 3 3 3 1 Skp1 family, dimerisation domain Acetyltransf_2 PF00797.17 KPI83444.1 - 1.1e-34 120.4 0.0 2e-34 119.5 0.0 1.5 1 1 0 1 1 1 1 N-acetyltransferase DUF3810 PF12725.7 KPI83445.1 - 0.56 9.5 1.8 0.51 9.6 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF3287 PF11690.8 KPI83446.1 - 10 5.9 11.3 0.48 10.1 0.9 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) Trp_repressor PF01371.19 KPI83447.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Trp repressor protein Tim17 PF02466.19 KPI83448.1 - 9.9e-15 54.9 9.7 1.4e-14 54.4 9.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MRP PF09387.10 KPI83449.1 - 4e-54 183.6 0.1 5.9e-54 183.0 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP GAS PF13851.6 KPI83451.1 - 0.22 10.9 15.0 0.52 9.6 5.5 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding NR_Repeat PF14046.6 KPI83451.1 - 0.23 11.6 2.2 0.61 10.3 2.2 1.6 1 0 0 1 1 1 0 Nuclear receptor repeat DUF4570 PF15134.6 KPI83451.1 - 0.33 11.0 8.8 4.4 7.4 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4570) AviRa PF11599.8 KPI83451.1 - 0.67 9.4 4.9 0.88 9.0 4.3 1.5 1 1 0 1 1 1 0 RRNA methyltransferase AviRa DUF5538 PF17692.1 KPI83451.1 - 0.82 9.7 4.3 1.9 8.6 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5538) Rx_N PF18052.1 KPI83451.1 - 0.89 9.9 4.8 4 7.8 0.0 3.1 2 1 0 2 2 2 0 Rx N-terminal domain DUF3847 PF12958.7 KPI83451.1 - 3.4 7.9 8.3 6.9 6.9 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) ABC_tran_CTD PF16326.5 KPI83451.1 - 5.7 7.3 10.5 3.8 7.8 2.7 3.2 3 0 0 3 3 3 0 ABC transporter C-terminal domain TTL PF03133.15 KPI83452.1 - 5.7e-69 232.5 0.0 9.7e-69 231.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KPI83452.1 - 6.4e-08 32.2 0.1 0.00026 20.3 0.0 3.3 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KPI83452.1 - 0.00022 20.6 0.0 0.021 14.1 0.0 2.5 2 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KPI83452.1 - 0.13 12.3 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain DUF2779 PF11074.8 KPI83454.1 - 4.5e-37 127.3 0.0 8.6e-37 126.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function(DUF2779) Ebola_NP PF05505.12 KPI83454.1 - 0.016 13.5 1.3 0.026 12.9 1.3 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein DNA_pol_B_2 PF03175.13 KPI83454.1 - 0.27 10.1 0.0 0.47 9.3 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral OPA3 PF07047.12 KPI83456.1 - 1.2e-14 54.1 12.8 1.3e-13 50.8 12.8 2.7 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) SPX PF03105.19 KPI83456.1 - 0.00018 21.5 3.5 0.00024 21.1 3.5 1.1 1 0 0 1 1 1 1 SPX domain Borrelia_P83 PF05262.11 KPI83456.1 - 0.019 13.4 4.4 0.03 12.8 4.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Spore_coat_CotO PF14153.6 KPI83456.1 - 0.24 11.3 7.0 0.19 11.6 3.2 2.2 2 0 0 2 2 2 0 Spore coat protein CotO MccV PF17508.2 KPI83456.1 - 2.1 9.0 8.4 1.2 9.7 4.9 2.1 2 0 0 2 2 2 0 Microcin V bacteriocin ATP-synt_E PF05680.12 KPI83456.1 - 2.6 8.5 10.7 1 9.8 4.2 2.7 3 0 0 3 3 3 0 ATP synthase E chain K_channel_TID PF07941.11 KPI83456.1 - 4.2 7.9 20.8 5.6 7.5 4.7 3.0 1 1 1 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain MRP-S31 PF15433.6 KPI83456.1 - 5.9 6.5 8.7 11 5.6 8.7 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Cmc1 PF08583.10 KPI83457.1 - 0.0012 18.8 1.7 0.0026 17.8 1.7 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like UPF0203 PF05254.12 KPI83457.1 - 0.33 11.2 4.2 0.16 12.3 1.4 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) tRNA-synt_2c PF01411.19 KPI83458.1 - 0.002 16.7 0.0 0.0028 16.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KPI83458.1 - 0.0066 16.5 0.1 0.017 15.2 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Toprim_3 PF13362.6 KPI83459.1 - 0.0052 17.1 0.6 1.3 9.4 0.2 2.9 2 0 0 2 2 2 2 Toprim domain FAD_binding_3 PF01494.19 KPI83461.1 - 3.4e-06 26.5 0.6 0.0072 15.6 0.1 2.8 2 1 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 KPI83461.1 - 0.00032 21.2 0.0 0.0013 19.2 0.0 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KPI83461.1 - 0.0021 17.7 2.1 0.0042 16.7 0.0 2.3 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KPI83461.1 - 0.0073 15.6 0.0 0.024 13.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF3549 PF12069.8 KPI83461.1 - 0.026 13.6 0.4 0.062 12.3 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3549) 3HCDH_N PF02737.18 KPI83461.1 - 0.09 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 KPI83461.1 - 0.14 12.4 0.0 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain DUF844 PF05815.11 KPI83461.1 - 0.16 11.2 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) PseudoU_synth_2 PF00849.22 KPI83462.1 - 1.2e-31 109.9 0.0 2.5e-31 108.9 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase NINJA_B PF16136.5 KPI83462.1 - 0.68 10.3 3.8 0.7 10.3 0.0 3.0 3 0 0 3 3 3 0 Putative nuclear localisation signal TPR_1 PF00515.28 KPI83463.1 - 4.3e-05 23.2 0.4 0.13 12.2 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI83463.1 - 0.0029 17.5 0.4 0.53 10.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI83463.1 - 0.0029 17.6 9.7 0.61 10.3 0.0 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83463.1 - 0.016 15.5 5.2 0.23 11.8 0.0 3.5 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KPI83463.1 - 0.048 14.0 0.9 2.6 8.6 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83463.1 - 0.13 12.8 6.4 1.6 9.3 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83463.1 - 0.3 11.8 9.0 7.4 7.3 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83463.1 - 0.35 11.1 2.2 7.1 6.9 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KPI83463.1 - 0.37 10.7 0.1 0.37 10.7 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat MRP-L47 PF06984.13 KPI83464.1 - 4.6e-27 94.0 0.1 9.4e-27 93.0 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Herpes_UL51 PF04540.13 KPI83464.1 - 0.045 13.5 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL51 protein PRIMA1 PF16101.5 KPI83464.1 - 6.8 6.8 8.2 8 6.5 1.2 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 A_deaminase PF00962.22 KPI83465.1 - 3.9e-88 296.0 0.1 8.8e-65 219.2 0.0 2.8 3 0 0 3 3 3 2 Adenosine/AMP deaminase ADH_N PF08240.12 KPI83466.1 - 1.3e-06 28.2 0.3 2.6e-06 27.3 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI83466.1 - 0.006 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF4164 PF13747.6 KPI83467.1 - 0.0013 19.0 0.9 0.0023 18.2 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4164) DUF1016_N PF17761.1 KPI83467.1 - 0.056 13.6 0.2 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 DUF1016 N-terminal domain KleE PF17394.2 KPI83468.1 - 0.31 11.3 2.4 0.75 10.0 2.4 1.6 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Brix PF04427.18 KPI83469.1 - 9.9e-34 117.1 0.0 1.4e-33 116.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain Peptidase_C50 PF03568.17 KPI83470.1 - 8.7e-39 133.8 0.5 3.6e-31 108.7 0.6 3.0 2 1 0 2 2 2 2 Peptidase family C50 CHAT PF12770.7 KPI83470.1 - 2.2e-06 27.3 0.1 2.5e-05 23.8 0.0 2.6 3 0 0 3 3 3 1 CHAT domain SNAP PF14938.6 KPI83471.1 - 9.8e-58 195.8 16.0 1.1e-57 195.6 16.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KPI83471.1 - 1.4e-05 25.2 4.9 0.00074 19.8 1.0 3.7 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83471.1 - 0.00074 20.1 10.4 0.2 12.3 3.3 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat SPO22 PF08631.10 KPI83471.1 - 0.0038 16.8 1.2 0.0051 16.3 1.2 1.2 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_MalT PF17874.1 KPI83471.1 - 0.0058 16.1 0.8 0.01 15.2 0.6 1.4 1 1 0 1 1 1 1 MalT-like TPR region TPR_5 PF12688.7 KPI83471.1 - 0.0075 16.5 0.1 1.1 9.6 0.0 2.5 2 0 0 2 2 2 1 Tetratrico peptide repeat Foie-gras_1 PF11817.8 KPI83471.1 - 0.054 13.1 0.7 0.11 12.1 0.4 1.5 1 1 0 1 1 1 0 Foie gras liver health family 1 TPR_7 PF13176.6 KPI83471.1 - 0.26 11.4 5.0 1.8 8.8 0.1 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83471.1 - 0.43 10.9 0.2 0.43 10.9 0.2 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF1033 PF06279.11 KPI83471.1 - 1.1 9.4 4.0 0.97 9.6 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1033) TPR_19 PF14559.6 KPI83471.1 - 1.1 9.8 13.5 2 9.0 1.1 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83471.1 - 2.3 9.3 7.9 9.6 7.3 0.2 4.9 3 1 3 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 KPI83471.1 - 3.5 7.8 7.3 0.46 10.6 0.3 3.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain NSF PF02071.20 KPI83471.1 - 7.8 7.8 14.8 1.8e+02 3.7 0.1 5.2 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_6 PF13174.6 KPI83471.1 - 10 7.0 13.6 1.1e+02 3.8 0.1 5.7 4 1 3 7 7 7 0 Tetratricopeptide repeat tRNA_U5-meth_tr PF05958.11 KPI83472.1 - 9.2e-19 67.6 0.0 4.2e-18 65.5 0.0 1.9 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 KPI83472.1 - 1.5e-09 37.8 0.0 2.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI83472.1 - 6.4e-08 33.2 0.0 1.8e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KPI83472.1 - 4.5e-06 26.6 0.0 8.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 KPI83472.1 - 6e-06 25.9 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 KPI83472.1 - 1.4e-05 24.9 0.0 3.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 KPI83472.1 - 0.00018 22.1 0.0 0.00052 20.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 KPI83472.1 - 0.00034 20.2 0.0 0.00057 19.5 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 KPI83472.1 - 0.00039 19.9 0.1 0.00065 19.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 KPI83472.1 - 0.00073 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 KPI83472.1 - 0.0018 18.3 0.0 0.0036 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI83472.1 - 0.0024 17.3 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 KPI83472.1 - 0.0026 17.3 0.0 0.0074 15.8 0.0 1.8 1 0 0 1 1 1 1 Putative methyltransferase RrnaAD PF00398.20 KPI83472.1 - 0.0029 16.7 0.1 0.006 15.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_23 PF13489.6 KPI83472.1 - 0.0047 16.8 0.0 0.011 15.5 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain TPMT PF05724.11 KPI83472.1 - 0.012 15.3 0.1 0.028 14.1 0.0 1.6 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.7 KPI83472.1 - 0.037 14.0 0.1 0.071 13.0 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KPI83472.1 - 0.039 13.7 0.2 0.085 12.6 0.2 1.5 1 0 0 1 1 1 0 Lysine methyltransferase RNA_ligase PF09414.10 KPI83474.1 - 1.7e-21 77.2 0.0 2.3e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 KPI83474.1 - 1.2e-08 35.0 0.0 3.2e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal OST-HTH PF12872.7 KPI83475.1 - 0.015 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 OST-HTH/LOTUS domain Hexapep PF00132.24 KPI83477.1 - 6.4e-10 38.4 8.4 3.3e-06 26.6 1.5 3.1 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KPI83477.1 - 0.0027 17.4 9.2 0.91 9.3 0.1 3.7 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase GTP_EFTU PF00009.27 KPI83478.1 - 1.4e-28 99.8 0.1 2.4e-28 99.0 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KPI83478.1 - 2.6e-09 37.3 0.1 6.5e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KPI83478.1 - 1.6e-07 31.4 0.0 4.9e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KPI83478.1 - 0.00039 19.9 0.2 0.0034 16.8 0.2 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit cobW PF02492.19 KPI83478.1 - 0.033 13.8 3.3 0.16 11.5 3.3 2.0 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 KPI83478.1 - 0.15 11.8 0.0 3.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Urm1 PF09138.11 KPI83479.1 - 5.1e-24 84.5 0.0 5.8e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 KPI83479.1 - 3.7e-07 30.7 0.0 4.6e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 ThiS family cNMP_binding PF00027.29 KPI83480.1 - 1.8e-24 85.6 0.2 2.3e-14 53.2 0.1 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Ribosomal_60s PF00428.19 KPI83480.1 - 0.046 14.3 0.8 0.046 14.3 0.8 3.9 3 1 1 4 4 4 0 60s Acidic ribosomal protein Peptidase_M14 PF00246.24 KPI83481.1 - 1.4e-17 64.4 0.0 4.3e-17 62.8 0.0 1.8 1 1 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 KPI83481.1 - 3.1e-07 30.7 0.0 6.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AstE_AspA PF04952.14 KPI83481.1 - 4.7e-05 22.6 0.0 7.4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family SRP68 PF16969.5 KPI83482.1 - 5.9e-51 174.1 12.7 1.1e-48 166.6 12.7 3.0 1 1 0 1 1 1 1 RNA-binding signal recognition particle 68 PNK3P PF08645.11 KPI83482.1 - 0.15 11.8 0.3 0.33 10.6 0.3 1.6 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Cation_ATPase_C PF00689.21 KPI83483.1 - 1e-17 64.4 10.3 1.2e-17 64.2 10.3 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus AA_permease_2 PF13520.6 KPI83483.1 - 0.67 8.7 10.4 0.38 9.5 2.5 2.0 1 1 1 2 2 2 0 Amino acid permease Metallophos PF00149.28 KPI83485.1 - 2.4e-23 83.7 0.0 4.1e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sgf11 PF08209.11 KPI83485.1 - 0.12 11.9 2.0 0.17 11.5 0.4 2.0 1 1 0 1 1 1 0 Sgf11 (transcriptional regulation protein) V-SNARE_C PF12352.8 KPI83486.1 - 2.4e-06 27.7 4.9 3.5e-06 27.2 4.9 1.1 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus MMPL PF03176.15 KPI83486.1 - 0.074 12.0 0.0 0.097 11.6 0.0 1.2 1 0 0 1 1 1 0 MMPL family DUF4407 PF14362.6 KPI83486.1 - 0.074 12.4 0.0 0.082 12.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ANAPC5 PF12862.7 KPI83488.1 - 0.94 9.6 4.7 2.5 8.2 4.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 CDP-OH_P_transf PF01066.21 KPI83489.1 - 3.9e-16 59.6 0.1 3.9e-16 59.6 0.1 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Dpy-30 PF05186.13 KPI83491.1 - 2.4e-13 49.5 0.0 3.4e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif E1-E2_ATPase PF00122.20 KPI83492.1 - 4.7e-22 78.4 1.4 1.1e-21 77.1 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KPI83492.1 - 1.2e-11 45.3 3.9 9.7e-05 22.7 0.1 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KPI83492.1 - 0.00014 21.9 0.0 0.0004 20.4 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KPI83492.1 - 0.01 15.6 0.6 0.11 12.2 0.1 2.6 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Sel1 PF08238.12 KPI83493.1 - 0.00048 20.7 10.5 0.37 11.6 0.1 4.2 4 1 0 4 4 4 2 Sel1 repeat Serine_rich PF08824.10 KPI83495.1 - 0.056 13.4 0.4 0.51 10.3 0.0 2.5 2 1 0 2 2 2 0 Serine rich protein interaction domain AP_endonuc_2 PF01261.24 KPI83495.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.6 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel SOGA PF11365.8 KPI83495.1 - 0.12 13.5 0.8 2.3 9.4 0.0 2.9 3 0 0 3 3 3 0 Protein SOGA DUF4201 PF13870.6 KPI83495.1 - 0.14 11.9 2.1 0.62 9.8 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Vir_act_alpha_C PF10400.9 KPI83495.1 - 0.17 12.6 5.1 0.49 11.1 0.8 2.6 2 0 0 2 2 2 0 Virulence activator alpha C-term THOC7 PF05615.13 KPI83495.1 - 1.3 9.3 6.8 23 5.3 3.1 2.7 2 1 0 2 2 2 0 Tho complex subunit 7 DUF883 PF05957.13 KPI83495.1 - 1.8 9.2 6.6 7.8 7.2 0.3 3.4 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) TEX13 PF15186.6 KPI83495.1 - 3 7.5 6.6 0.38 10.4 0.1 2.5 3 0 0 3 3 3 0 Testis-expressed sequence 13 protein family Rotamase PF00639.21 KPI83496.1 - 2.1e-19 70.3 0.0 2.3e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KPI83496.1 - 4.9e-15 56.1 0.0 6.3e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain PIF1 PF05970.14 KPI83497.1 - 1.1e-40 140.0 0.0 4.6e-34 118.2 0.0 2.6 3 0 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 KPI83497.1 - 1.2e-12 48.0 0.0 2.2e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 KPI83497.1 - 9.7e-12 43.6 3.3 7.5e-07 27.5 0.1 2.1 2 0 0 2 2 2 2 Helicase AAA_19 PF13245.6 KPI83497.1 - 5e-09 36.6 0.0 1.6e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KPI83497.1 - 0.00027 20.7 0.3 0.0086 15.8 0.2 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 KPI83497.1 - 0.0004 19.6 0.1 0.0011 18.1 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_11 PF13086.6 KPI83497.1 - 0.00053 19.9 0.0 0.16 11.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KPI83497.1 - 0.0007 19.9 0.0 0.0016 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KPI83497.1 - 0.0081 16.0 0.0 0.021 14.6 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_7 PF12775.7 KPI83497.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 KPI83497.1 - 0.013 15.9 0.0 0.048 14.0 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 KPI83497.1 - 0.031 14.0 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 KPI83497.1 - 0.038 14.5 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 KPI83497.1 - 0.041 13.8 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 KPI83497.1 - 0.066 13.0 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4314 PF14192.6 KPI83497.1 - 0.11 12.4 0.0 0.46 10.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4314) DUF2075 PF09848.9 KPI83497.1 - 0.14 11.4 0.1 0.26 10.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 KPI83497.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeS_assembly_P PF01883.19 KPI83498.1 - 2e-10 40.7 0.0 5.9e-10 39.2 0.0 1.8 2 1 0 2 2 2 1 Iron-sulfur cluster assembly protein Glyco_hydro_1 PF00232.18 KPI83498.1 - 0.025 13.0 0.0 0.029 12.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 DUF1802 PF08819.11 KPI83498.1 - 0.031 14.1 0.1 0.045 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1802) NPL PF17800.1 KPI83499.1 - 3.6e-12 46.8 0.0 3.6e-12 46.8 0.0 2.9 2 1 0 2 2 2 1 Nucleoplasmin-like domain SURF2 PF05477.11 KPI83499.1 - 4.2 7.0 19.5 6.7 6.3 19.5 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RL11D PF11088.8 KPI83500.1 - 0.065 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 SUKH-4 PF14435.6 KPI83500.1 - 0.068 13.2 0.7 0.12 12.4 0.7 1.4 1 0 0 1 1 1 0 SUKH-4 immunity protein NrsF PF06532.11 KPI83501.1 - 3.1 7.4 7.2 0.53 10.0 2.5 2.1 2 0 0 2 2 2 0 Negative regulator of sigma F AAA_6 PF12774.7 KPI83502.1 - 7.4e-153 508.3 0.0 6.7e-152 505.1 0.0 2.5 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI83502.1 - 1.1e-114 383.6 13.5 1.1e-114 383.6 13.5 3.8 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KPI83502.1 - 4.1e-103 344.8 7.7 9.1e-103 343.7 0.0 3.7 4 0 0 4 4 4 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KPI83502.1 - 2.6e-99 331.8 0.0 4.8e-98 327.6 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KPI83502.1 - 2.4e-80 268.8 0.1 4.3e-79 264.7 0.3 3.1 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI83502.1 - 1.3e-66 223.5 2.1 1.4e-64 216.9 0.0 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI83502.1 - 1e-52 178.3 0.0 6.7e-52 175.6 0.0 2.5 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI83502.1 - 4.7e-47 159.0 0.2 5.4e-45 152.3 0.0 4.3 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI83502.1 - 5.4e-45 153.9 10.4 5.4e-45 153.9 10.4 1.8 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 KPI83502.1 - 5.5e-23 81.5 0.2 2.2e-22 79.5 0.2 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KPI83502.1 - 3.9e-14 52.7 0.1 3.4e-13 49.6 0.1 2.7 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 KPI83502.1 - 5.3e-13 49.1 0.0 0.0019 18.2 0.0 6.8 5 2 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KPI83502.1 - 4.5e-09 36.7 0.3 2.5e-05 24.6 0.0 4.2 3 0 0 3 3 2 1 AAA domain AAA PF00004.29 KPI83502.1 - 5.8e-06 26.8 0.1 0.48 10.8 0.0 4.0 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KPI83502.1 - 8.2e-06 26.2 0.1 0.064 13.6 0.0 4.1 5 0 0 5 5 3 2 RNA helicase NACHT PF05729.12 KPI83502.1 - 0.00023 21.1 0.1 0.03 14.2 0.0 3.3 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 KPI83502.1 - 0.002 18.5 7.1 1.5 9.2 0.0 4.9 5 0 0 5 5 5 2 AAA ATPase domain AAA_18 PF13238.6 KPI83502.1 - 0.008 16.7 0.1 3.1 8.4 0.0 4.4 4 0 0 4 4 2 1 AAA domain AAA_30 PF13604.6 KPI83502.1 - 0.027 14.2 5.4 1.7 8.3 0.1 3.4 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 KPI83502.1 - 0.035 13.8 0.1 9.5 5.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 KPI83502.1 - 0.15 12.1 0.0 10 6.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain NuiA PF07924.11 KPI83502.1 - 2.6 8.4 7.5 0.62 10.5 0.3 3.4 3 0 0 3 3 2 0 Nuclease A inhibitor-like protein MutS_III PF05192.18 KPI83502.1 - 5.3 7.2 13.9 1.6 8.9 3.5 4.1 3 1 0 3 3 3 0 MutS domain III AAA_33 PF13671.6 KPI83502.1 - 5.7 7.1 9.0 1.4 9.0 0.0 3.9 4 0 0 4 4 2 0 AAA domain Bromodomain PF00439.25 KPI83504.1 - 0.0016 18.5 0.1 0.011 15.7 0.1 2.2 1 1 0 1 1 1 1 Bromodomain Macoilin PF09726.9 KPI83504.1 - 0.027 13.1 21.1 0.21 10.1 0.0 2.9 3 0 0 3 3 3 0 Macoilin family zf-CW PF07496.15 KPI83504.1 - 0.075 13.1 2.8 0.19 11.8 2.8 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger Serine_rich PF08824.10 KPI83504.1 - 0.22 11.5 2.7 0.59 10.1 2.7 1.7 1 0 0 1 1 1 0 Serine rich protein interaction domain Thr_synth_N PF14821.6 KPI83505.1 - 1.2e-12 47.8 0.1 5.7e-12 45.7 0.0 2.2 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 KPI83505.1 - 6.1e-11 42.3 0.0 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Ntox44 PF15607.6 KPI83505.1 - 0.049 13.9 0.0 0.096 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 44 IPK PF03770.16 KPI83506.1 - 5.1e-41 140.7 0.1 9.8e-41 139.8 0.1 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Aa_trans PF01490.18 KPI83507.1 - 1.1e-28 100.1 20.1 1.6e-28 99.6 20.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KPI83508.1 - 2.4e-08 33.1 28.2 3.8e-08 32.5 28.2 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3754 PF12576.8 KPI83508.1 - 0.044 13.7 1.7 0.15 12.0 1.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) YcgR PF07317.12 KPI83508.1 - 0.066 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Flagellar regulator YcgR DUF3810 PF12725.7 KPI83508.1 - 3 7.1 4.3 0.57 9.5 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Solute_trans_a PF03619.16 KPI83509.1 - 1.3e-71 241.2 15.1 1.7e-71 240.9 15.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Prok-RING_2 PF14445.6 KPI83509.1 - 0.055 13.6 0.4 0.14 12.4 0.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 Fumarate_red_D PF02313.17 KPI83509.1 - 0.8 9.8 7.2 0.15 12.2 2.0 2.2 2 0 0 2 2 2 0 Fumarate reductase subunit D Skp1 PF01466.19 KPI83510.1 - 1.3e-26 92.4 2.2 2.1e-26 91.7 2.2 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 KPI83510.1 - 2.7e-12 46.7 0.0 2.6e-11 43.5 0.0 2.3 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain ABC2_membrane_3 PF12698.7 KPI83511.1 - 1.3e-60 205.3 42.8 3.5e-39 134.9 16.7 3.1 3 0 0 3 3 3 3 ABC-2 family transporter protein ABC_tran PF00005.27 KPI83511.1 - 1.2e-54 184.5 0.0 1.2e-27 97.1 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KPI83511.1 - 7.7e-15 55.5 0.5 1.5e-05 25.0 0.0 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI83511.1 - 3.3e-05 24.5 0.8 0.3 11.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KPI83511.1 - 0.00045 20.2 0.1 0.53 10.2 0.0 3.2 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 KPI83511.1 - 0.0013 18.4 0.4 0.52 10.1 0.0 3.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 KPI83511.1 - 0.0017 18.6 0.0 2.2 8.6 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 KPI83511.1 - 0.0042 16.8 3.4 0.75 9.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain DUF4162 PF13732.6 KPI83511.1 - 0.0047 17.6 0.0 0.084 13.6 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 KPI83511.1 - 0.016 14.9 0.0 6.8 6.3 0.0 3.7 4 0 0 4 4 4 0 AAA ATPase domain Zeta_toxin PF06414.12 KPI83511.1 - 0.017 14.4 0.4 26 4.0 0.0 3.4 3 0 0 3 3 3 0 Zeta toxin MukB PF04310.12 KPI83511.1 - 0.043 13.6 0.5 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 MukB N-terminal DUF2172 PF09940.9 KPI83511.1 - 0.071 13.5 0.0 0.93 9.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2172) SRP54 PF00448.22 KPI83511.1 - 0.16 11.6 8.7 0.9 9.1 0.0 2.7 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain AAA PF00004.29 KPI83511.1 - 0.16 12.4 0.3 3.3 8.1 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KPI83511.1 - 0.16 12.2 0.6 5.2 7.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain VirE PF05272.11 KPI83511.1 - 0.18 11.5 0.0 6.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_22 PF13401.6 KPI83511.1 - 0.91 9.8 2.6 10 6.4 0.1 3.4 3 0 0 3 3 3 0 AAA domain ABC2_membrane PF01061.24 KPI83511.1 - 6.4 6.1 51.8 0.13 11.7 13.4 4.9 4 1 0 4 4 4 0 ABC-2 type transporter DUF2730 PF10805.8 KPI83511.1 - 7.7 6.7 5.2 2.6 8.2 0.9 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) HSP20 PF00011.21 KPI83513.1 - 5.2e-17 61.9 0.0 5.9e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KPI83513.1 - 7.3e-08 31.9 0.0 3e-07 29.9 0.0 1.8 1 1 0 1 1 1 1 HSP20-like domain found in ArsA PapC_N PF13954.6 KPI83513.1 - 0.15 12.1 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 PapC N-terminal domain PDEase_I PF00233.19 KPI83514.1 - 9.9e-77 257.9 3.8 1.2e-76 257.6 2.6 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase CotH PF08757.11 KPI83516.1 - 2 7.9 4.2 0.79 9.2 0.9 2.0 2 0 0 2 2 2 0 CotH kinase protein Acyltransferase PF01553.21 KPI83517.1 - 6.5e-08 32.3 0.0 1.2e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase JmjN PF02375.17 KPI83517.1 - 0.021 14.8 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 jmjN domain NIF PF03031.18 KPI83518.1 - 1.3e-28 99.7 0.0 1.9e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.12 KPI83518.1 - 0.0015 18.0 0.0 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) NSP2_assoc PF14758.6 KPI83518.1 - 0.046 14.1 1.4 6.7 7.0 0.1 2.2 2 0 0 2 2 2 0 Non-essential region of nsp2 of arterivirus polyprotein C2 PF00168.30 KPI83519.1 - 0.0039 17.5 0.0 0.005 17.1 0.0 1.2 1 0 0 1 1 1 1 C2 domain Hist_deacetyl PF00850.19 KPI83520.1 - 1.8e-71 241.1 0.2 2.3e-71 240.8 0.2 1.1 1 0 0 1 1 1 1 Histone deacetylase domain zf-RING_UBOX PF13445.6 KPI83521.1 - 4.5e-08 33.0 5.8 4.5e-08 33.0 5.8 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KPI83521.1 - 5e-07 29.5 10.5 1.3e-05 24.9 10.5 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI83521.1 - 1.1e-06 28.4 12.3 1.8e-06 27.7 9.9 2.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI83521.1 - 2.9e-06 27.2 9.0 2.9e-06 27.2 9.0 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KPI83521.1 - 3.8e-05 23.4 7.9 3.8e-05 23.4 7.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KPI83521.1 - 0.00023 21.0 4.1 0.00049 19.9 4.1 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 KPI83521.1 - 0.00089 19.4 5.8 0.00089 19.4 5.8 2.6 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KPI83521.1 - 0.0012 19.2 14.1 0.003 17.9 13.6 2.1 1 1 1 2 2 2 1 Ring finger domain DZR PF12773.7 KPI83521.1 - 0.029 14.4 10.7 1.3 9.1 9.9 2.3 1 1 1 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.6 KPI83521.1 - 0.04 13.8 15.7 0.048 13.5 4.5 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 AraC_N PF06719.13 KPI83521.1 - 0.11 12.2 0.3 1.9 8.1 0.0 2.2 2 1 0 2 2 2 0 AraC-type transcriptional regulator N-terminus DUF2321 PF10083.9 KPI83521.1 - 0.16 11.6 4.4 0.24 11.0 4.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-RING_11 PF17123.5 KPI83521.1 - 0.2 11.4 7.7 0.1 12.4 4.4 2.2 2 0 0 2 2 2 0 RING-like zinc finger HypA PF01155.19 KPI83521.1 - 3 7.9 10.6 19 5.3 1.3 2.6 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Siva PF05458.12 KPI83521.1 - 6.7 6.4 12.2 2 8.0 9.6 1.5 2 0 0 2 2 2 0 Cd27 binding protein (Siva) Dymeclin PF09742.9 KPI83522.1 - 1.8e-53 181.9 0.0 2.7e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 KPI83522.1 - 1.7e-31 109.2 0.0 5.7e-27 94.2 0.0 4.0 3 1 0 3 3 3 2 High-temperature-induced dauer-formation protein GCSF PF16647.5 KPI83522.1 - 0.024 14.5 0.1 3 7.7 0.1 2.5 2 0 0 2 2 2 0 Granulocyte colony-stimulating factor IQ PF00612.27 KPI83523.1 - 1.3e-09 37.0 34.6 0.013 15.2 0.2 6.3 6 0 0 6 6 6 5 IQ calmodulin-binding motif DUF410 PF04190.13 KPI83523.1 - 0.097 12.5 1.5 0.19 11.5 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF410) GTP_EFTU PF00009.27 KPI83524.1 - 6.8e-24 84.5 2.2 3.4e-22 78.9 2.2 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI83524.1 - 6.2e-10 39.2 0.1 2.1e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI83524.1 - 9e-05 22.4 0.1 0.072 13.0 0.3 2.6 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 KPI83524.1 - 0.00045 20.0 0.0 0.0026 17.5 0.0 2.2 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 KPI83524.1 - 0.0011 18.5 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family IF-2 PF11987.8 KPI83524.1 - 0.0026 17.9 0.0 0.0059 16.7 0.0 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 FeoB_N PF02421.18 KPI83524.1 - 0.0048 16.4 0.1 0.013 15.0 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KPI83524.1 - 0.0049 16.7 0.0 0.024 14.4 0.1 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 KPI83524.1 - 0.0049 16.3 0.0 0.013 15.0 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KPI83524.1 - 0.02 15.1 0.0 0.05 13.8 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 KPI83524.1 - 0.046 13.3 0.2 0.33 10.5 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TRAPP PF04051.16 KPI83526.1 - 1.1e-11 44.7 0.0 1.5e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Pro_isomerase PF00160.21 KPI83527.1 - 1e-20 74.6 0.0 1.4e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD UCH PF00443.29 KPI83529.1 - 1.1e-43 149.7 0.5 1.8e-43 148.9 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI83529.1 - 3.9e-10 39.8 4.7 2.6e-09 37.1 4.7 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SNF2_N PF00176.23 KPI83530.1 - 2.9e-35 121.6 0.0 4.7e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI83530.1 - 2.4e-10 40.8 0.0 5.5e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI83530.1 - 4.9e-08 33.2 0.0 9.2e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KPI83530.1 - 0.079 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain TniB PF05621.11 KPI83530.1 - 0.21 10.9 0.0 0.42 10.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Npa1 PF11707.8 KPI83531.1 - 1.1e-09 38.2 0.0 1.5e-08 34.4 0.0 2.6 1 1 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 KPI83531.1 - 0.00021 20.9 2.7 0.00029 20.5 0.3 2.7 2 1 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 DUF2681 PF10883.8 KPI83534.1 - 0.00063 20.1 0.1 0.00084 19.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) LapA_dom PF06305.11 KPI83534.1 - 0.004 16.9 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 KPI83534.1 - 0.012 16.5 0.0 0.015 16.2 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.12 KPI83534.1 - 0.019 14.5 0.0 0.02 14.5 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family CENP-K PF11802.8 KPI83534.1 - 0.053 13.1 0.4 0.063 12.9 0.4 1.0 1 0 0 1 1 1 0 Centromere-associated protein K PetG PF02529.15 KPI83534.1 - 0.12 12.3 0.2 0.17 11.7 0.2 1.2 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 DUF4381 PF14316.6 KPI83535.1 - 0.00021 21.5 0.9 0.00026 21.2 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) UL97 PF06734.12 KPI83535.1 - 0.057 13.3 1.7 0.067 13.1 1.5 1.3 1 1 0 1 1 1 0 UL97 Glyco_hydro_100 PF12899.7 KPI83535.1 - 0.12 11.0 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase RSN1_TM PF13967.6 KPI83535.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport UL16 PF17622.2 KPI83535.1 - 0.13 11.9 1.8 0.23 11.1 1.8 1.4 1 1 0 1 1 1 0 Viral unique long protein 16 DUF3094 PF11293.8 KPI83535.1 - 0.22 11.2 0.2 0.22 11.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) EF-hand_1 PF00036.32 KPI83536.1 - 0.072 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 EF hand DUF3865 PF12981.7 KPI83537.1 - 0.016 15.2 0.3 0.031 14.2 0.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3865) TolA_bind_tri PF16331.5 KPI83537.1 - 0.032 14.3 2.1 0.032 14.3 2.1 3.5 2 1 1 3 3 3 0 TolA binding protein trimerisation Gp58 PF07902.11 KPI83537.1 - 0.16 10.2 7.9 0.23 9.7 7.9 1.2 1 0 0 1 1 1 0 gp58-like protein Cnn_1N PF07989.11 KPI83537.1 - 0.64 10.2 7.2 0.72 10.1 1.3 3.0 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DMPK_coil PF08826.10 KPI83537.1 - 0.94 9.6 0.0 0.94 9.6 0.0 3.2 3 0 0 3 3 3 0 DMPK coiled coil domain like PUF PF00806.19 KPI83538.1 - 2.3e-27 93.1 0.7 1.7e-05 24.2 0.0 5.6 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat CPL PF08144.11 KPI83538.1 - 0.014 15.8 0.4 22 5.4 0.0 3.5 1 1 2 3 3 3 0 CPL (NUC119) domain MRP-L46 PF11788.8 KPI83540.1 - 1.7e-12 48.1 0.0 5.9e-12 46.4 0.0 1.9 1 1 0 1 1 1 1 39S mitochondrial ribosomal protein L46 WD40 PF00400.32 KPI83541.1 - 2.2e-55 183.4 26.9 4.5e-09 36.8 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat WD40_like PF17005.5 KPI83541.1 - 7.5e-08 32.0 0.3 0.00076 18.9 0.0 3.2 2 1 1 3 3 3 2 WD40-like domain ANAPC4_WD40 PF12894.7 KPI83541.1 - 8.9e-08 32.3 1.2 0.014 15.7 0.0 4.7 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI83541.1 - 3.6e-07 29.2 16.0 0.01 14.5 1.0 5.4 1 1 4 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 KPI83541.1 - 1.4e-06 28.3 7.5 0.05 13.5 0.1 3.8 2 1 3 5 5 5 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 KPI83541.1 - 0.00033 19.3 4.0 0.0089 14.6 0.4 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain PB1 PF00564.24 KPI83541.1 - 0.0029 17.5 0.0 0.0082 16.1 0.0 1.8 1 0 0 1 1 1 1 PB1 domain LRR_4 PF12799.7 KPI83542.1 - 1.1e-16 60.6 2.7 0.0019 18.5 0.1 7.1 5 2 4 9 9 9 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83542.1 - 3.4e-08 33.1 1.9 1.4 8.8 0.0 6.8 6 1 0 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 KPI83542.1 - 0.00016 21.2 0.3 0.014 14.9 0.0 3.4 3 1 1 4 4 4 1 Leucine-rich repeat LRR_6 PF13516.6 KPI83542.1 - 5.1 7.4 22.6 4.1 7.7 0.4 8.0 12 0 0 12 12 12 0 Leucine Rich repeat Pkinase_C PF00433.24 KPI83543.1 - 0.017 15.8 0.4 0.047 14.4 0.4 1.7 1 1 0 1 1 1 0 Protein kinase C terminal domain zf-MIZ PF02891.20 KPI83544.1 - 1.1e-19 69.8 1.7 2.1e-19 69.0 1.7 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KPI83544.1 - 9.2e-05 22.2 0.2 0.00017 21.3 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Hemerythrin PF01814.23 KPI83544.1 - 0.097 13.3 0.1 0.21 12.2 0.1 1.5 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain Mito_carr PF00153.27 KPI83546.1 - 1.8e-52 175.2 0.8 4.7e-19 68.1 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein HECT PF00632.25 KPI83547.1 - 2.5e-49 168.5 0.0 5.4e-49 167.3 0.0 1.5 2 0 0 2 2 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 KPI83547.1 - 4.1e-44 150.9 0.0 1.1e-43 149.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83547.1 - 3.1e-28 98.8 0.0 8.6e-28 97.3 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_2 PF07719.17 KPI83547.1 - 2e-11 43.1 8.0 0.00013 21.8 0.2 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83547.1 - 4.7e-10 38.8 14.3 0.00019 21.1 0.3 4.1 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83547.1 - 1.6e-07 30.9 7.1 0.085 13.1 0.1 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83547.1 - 7.8e-05 22.9 8.6 0.15 12.4 1.6 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI83547.1 - 0.00039 20.0 6.6 0.028 14.1 2.7 3.6 2 1 2 4 4 4 2 TPR repeat TPR_16 PF13432.6 KPI83547.1 - 0.0009 19.8 1.9 0.0009 19.8 1.9 3.1 2 1 0 2 2 1 1 Tetratricopeptide repeat Kinase-like PF14531.6 KPI83547.1 - 0.0013 18.1 0.0 0.0013 18.1 0.0 2.1 2 0 0 2 2 1 1 Kinase-like TPR_6 PF13174.6 KPI83547.1 - 0.0027 18.2 8.5 0.15 12.8 0.2 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Pkinase_fungal PF17667.1 KPI83547.1 - 0.0033 16.3 0.0 0.0033 16.3 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase TPR_19 PF14559.6 KPI83547.1 - 0.0085 16.6 12.1 0.039 14.5 0.4 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83547.1 - 0.0096 16.7 2.8 2.4 9.2 0.0 4.5 3 0 0 3 3 3 1 Tetratricopeptide repeat APH PF01636.23 KPI83547.1 - 0.011 15.7 0.0 0.011 15.7 0.0 2.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 KPI83547.1 - 0.021 14.4 0.6 0.069 12.7 0.0 2.2 2 0 0 2 2 2 0 RIO1 family TPR_7 PF13176.6 KPI83547.1 - 0.07 13.2 0.1 0.58 10.3 0.1 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI83547.1 - 0.25 11.5 4.7 1.4 9.1 0.1 3.7 3 1 1 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI83547.1 - 0.35 11.0 7.6 4.2 7.5 0.4 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 KPI83547.1 - 0.37 11.3 4.0 1.6 9.2 1.4 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI83547.1 - 5.3 7.1 12.0 5 7.1 0.4 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1077 PF06417.12 KPI83550.1 - 1.3e-36 125.1 0.8 1.6e-36 124.9 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) PqiA PF04403.13 KPI83550.1 - 0.05 13.4 2.4 0.07 13.0 2.4 1.2 1 0 0 1 1 1 0 Paraquat-inducible protein A HSP33 PF01430.19 KPI83551.1 - 3.3e-13 49.7 0.0 1.5e-06 27.9 0.0 2.3 2 0 0 2 2 2 2 Hsp33 protein CRAL_TRIO PF00650.20 KPI83552.1 - 3e-24 85.6 0.0 3.8e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KPI83552.1 - 0.0004 20.5 0.0 0.00057 20.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KPI83552.1 - 0.014 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain AAA_22 PF13401.6 KPI83555.1 - 2.3e-06 27.9 0.0 1.9e-05 25.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 KPI83555.1 - 2.7e-06 27.6 0.0 4.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KPI83555.1 - 0.00016 21.7 0.0 0.00035 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 KPI83555.1 - 0.0024 18.3 0.0 0.0069 16.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI83555.1 - 0.0053 17.2 0.2 0.83 10.0 0.0 3.7 3 0 0 3 3 3 1 AAA ATPase domain DUF2207 PF09972.9 KPI83555.1 - 0.0055 15.5 0.1 0.099 11.4 0.1 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) RuvB_N PF05496.12 KPI83555.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 KPI83555.1 - 0.077 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain AAA_33 PF13671.6 KPI83555.1 - 0.11 12.7 0.0 0.57 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain E1-E2_ATPase PF00122.20 KPI83555.1 - 0.32 10.5 2.1 0.83 9.1 2.1 1.7 1 0 0 1 1 1 0 E1-E2 ATPase Ras PF00071.22 KPI83556.1 - 2e-39 134.8 0.0 2.5e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI83556.1 - 2.5e-26 92.3 0.0 5.7e-26 91.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI83556.1 - 1.6e-10 40.7 0.0 2.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI83556.1 - 0.00033 20.7 0.0 0.00069 19.7 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KPI83556.1 - 0.0015 18.0 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KPI83556.1 - 0.0021 17.6 0.0 2 7.9 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KPI83556.1 - 0.0077 16.1 0.1 3 7.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KPI83556.1 - 0.062 13.7 0.1 0.11 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Enkurin PF13864.6 KPI83558.1 - 0.0082 16.6 10.4 0.0082 16.6 10.4 2.5 2 0 0 2 2 2 1 Calmodulin-binding Med25_NR-box PF11244.8 KPI83558.1 - 0.065 13.6 0.7 0.16 12.4 0.7 1.6 1 0 0 1 1 1 0 Mediator complex subunit 25 C-terminal NR box-containing RasGAP_C PF03836.15 KPI83558.1 - 0.09 12.9 7.5 0.32 11.1 3.5 2.3 2 0 0 2 2 2 0 RasGAP C-terminus LPD5 PF18799.1 KPI83558.1 - 0.22 11.9 0.1 0.22 11.9 0.1 2.8 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 5 Spc29 PF17082.5 KPI83558.1 - 0.29 10.9 9.5 0.038 13.8 1.3 2.5 2 1 0 2 2 2 0 Spindle Pole Component 29 tRNA_bind PF01588.20 KPI83559.1 - 4.6e-27 94.0 0.0 9.9e-27 92.9 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain Dynamin_N PF00350.23 KPI83560.1 - 2.3e-10 40.8 0.0 7.3e-10 39.2 0.0 1.8 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KPI83560.1 - 1.8e-08 34.5 0.0 7.9e-08 32.4 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI83560.1 - 0.00023 21.1 0.4 0.0038 17.1 0.2 2.6 2 1 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 KPI83560.1 - 0.01 16.4 0.0 0.019 15.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Roc PF08477.13 KPI83560.1 - 0.012 15.8 0.0 0.88 9.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KPI83560.1 - 0.016 14.7 0.0 0.38 10.3 0.0 2.4 2 1 0 2 2 2 0 Ferrous iron transport protein B Septin PF00735.18 KPI83560.1 - 0.1 11.9 0.1 0.37 10.0 0.0 1.8 2 0 0 2 2 2 0 Septin DUF5345 PF17280.2 KPI83560.1 - 0.11 12.4 0.1 0.34 10.9 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF2717 PF10911.8 KPI83560.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) Arf PF00025.21 KPI83560.1 - 0.16 11.4 0.1 0.54 9.7 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family Pkinase PF00069.25 KPI83561.1 - 2.9e-43 148.2 0.0 3.3e-36 125.0 0.0 3.3 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83561.1 - 4.2e-19 68.8 0.0 1.2e-16 60.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KPI83561.1 - 2.8e-05 23.6 0.0 0.00017 21.0 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI83561.1 - 0.00046 20.2 0.0 0.00089 19.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KPI83561.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Med26 PF08711.11 KPI83562.1 - 1.3e-05 25.1 8.5 0.0014 18.6 0.0 3.6 3 0 0 3 3 3 2 TFIIS helical bundle-like domain RabGAP-TBC PF00566.18 KPI83564.1 - 1.8e-35 122.6 0.1 2.5e-35 122.1 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FHA PF00498.26 KPI83565.1 - 1.5e-14 54.1 0.0 2.4e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain Rotamase PF00639.21 KPI83565.1 - 5.2e-12 46.6 0.0 1.5e-11 45.1 0.0 1.9 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KPI83565.1 - 4.1e-09 37.0 0.0 8.6e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Yop-YscD_cpl PF16697.5 KPI83565.1 - 1.4e-06 28.5 0.0 2.8e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Rotamase_2 PF13145.6 KPI83565.1 - 0.0019 19.1 1.9 0.0061 17.4 0.0 2.5 3 0 0 3 3 3 1 PPIC-type PPIASE domain Oxidored_FMN PF00724.20 KPI83566.1 - 1.7e-67 228.1 0.0 2.4e-67 227.6 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.14 KPI83566.1 - 2.7e-20 72.8 0.1 9.3e-20 71.0 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI83566.1 - 2.1e-09 37.5 0.1 1.3e-08 35.0 0.0 2.4 3 0 0 3 3 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KPI83566.1 - 1.1e-08 35.5 0.1 0.00026 21.5 0.2 3.6 3 1 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI83566.1 - 1.4e-07 30.6 2.4 8.4e-06 24.7 0.4 2.9 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 KPI83566.1 - 8.8e-07 28.8 1.8 3.9e-05 23.4 0.6 2.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KPI83566.1 - 1.2e-06 28.2 1.5 1.9e-06 27.5 1.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KPI83566.1 - 4.9e-06 25.9 3.6 4.9e-05 22.6 1.4 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 KPI83566.1 - 5.4e-06 25.9 0.5 0.024 13.9 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KPI83566.1 - 3e-05 23.3 0.0 5.8e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A K_oxygenase PF13434.6 KPI83566.1 - 0.00013 21.2 0.6 0.6 9.2 0.0 3.1 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 KPI83566.1 - 0.00051 19.4 1.1 0.0026 17.1 0.4 2.2 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 KPI83566.1 - 0.00093 19.1 1.0 0.031 14.1 0.2 2.7 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KPI83566.1 - 0.0011 19.3 0.2 0.083 13.3 0.0 3.1 3 1 0 3 3 3 1 Putative NAD(P)-binding Amino_oxidase PF01593.24 KPI83566.1 - 0.0015 17.9 0.2 0.022 14.1 0.1 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 KPI83566.1 - 0.0022 18.0 0.5 0.39 10.7 0.1 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 KPI83566.1 - 0.0035 16.6 0.1 0.0089 15.3 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_Gly3P_dh_N PF01210.23 KPI83566.1 - 0.0066 16.4 0.0 0.1 12.5 0.0 2.3 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FMO-like PF00743.19 KPI83566.1 - 0.02 13.4 0.1 12 4.1 0.0 2.9 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 KPI83566.1 - 0.032 13.5 0.2 0.081 12.2 0.2 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 KPI83566.1 - 0.081 12.6 0.3 4.4 6.9 0.1 2.8 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 KPI83566.1 - 0.087 13.1 0.1 22 5.3 0.0 3.0 2 1 1 3 3 3 0 Saccharopine dehydrogenase NADP binding domain Trp_halogenase PF04820.14 KPI83566.1 - 0.13 11.1 1.5 0.2 10.4 0.7 1.7 2 0 0 2 2 2 0 Tryptophan halogenase S-AdoMet_synt_M PF02772.16 KPI83566.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, central domain Sulfotransfer_4 PF17784.1 KPI83569.1 - 9.1e-43 146.6 0.0 2.1e-42 145.4 0.0 1.6 2 0 0 2 2 2 1 Sulfotransferase domain Rota_NS26 PF01525.16 KPI83570.1 - 0.056 13.5 3.8 0.12 12.3 3.8 1.7 1 1 0 1 1 1 0 Rotavirus NS26 DnaJ PF00226.31 KPI83573.1 - 1.8e-24 85.7 0.7 3.5e-24 84.7 0.7 1.5 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.9 KPI83573.1 - 0.0025 17.5 15.3 0.0025 17.5 15.3 2.5 2 1 1 3 3 3 1 Transmembrane Fragile-X-F protein DUF1180 PF06679.12 KPI83573.1 - 5.2 7.4 6.6 5.5 7.4 1.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Vps51 PF08700.11 KPI83574.1 - 0.045 13.8 0.0 0.06 13.4 0.0 1.3 1 0 0 1 1 1 0 Vps51/Vps67 FtsJ PF01728.19 KPI83575.1 - 4.7e-45 153.8 0.0 5.5e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 KPI83575.1 - 1e-05 25.4 0.1 2.8e-05 24.0 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain SET PF00856.28 KPI83576.1 - 1.9e-12 47.9 0.0 1e-11 45.5 0.0 1.9 1 1 0 1 1 1 1 SET domain MMgT PF10270.9 KPI83579.1 - 0.0039 17.5 0.0 0.0092 16.3 0.0 1.6 1 0 0 1 1 1 1 Membrane magnesium transporter AMPKBI PF04739.15 KPI83580.1 - 4e-14 52.6 1.8 1.1e-13 51.2 1.8 1.8 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 KPI83580.1 - 7.4e-08 32.5 0.0 1.4e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase KxDL PF10241.9 KPI83582.1 - 0.0004 20.6 0.7 0.0004 20.6 0.7 11.5 10 3 5 16 16 16 2 Uncharacterized conserved protein Baculo_p24 PF05073.12 KPI83582.1 - 0.0011 18.8 6.0 0.0011 18.8 6.0 6.3 2 2 3 5 5 5 1 Baculovirus P24 capsid protein PI_PP_I PF18363.1 KPI83582.1 - 0.025 14.7 0.4 0.5 10.6 0.1 3.6 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain NTP_transf_4 PF13562.6 KPI83582.1 - 0.35 11.1 7.1 0.29 11.3 1.5 3.4 3 0 0 3 3 3 0 Sugar nucleotidyl transferase HALZ PF02183.18 KPI83582.1 - 1.2 9.4 21.9 0.42 10.9 0.2 5.8 5 0 0 5 5 5 0 Homeobox associated leucine zipper Destabilase PF05497.12 KPI83583.1 - 0.43 10.9 2.2 6.3 7.2 0.3 2.2 2 0 0 2 2 2 0 Destabilase TFIIA PF03153.13 KPI83583.1 - 1.6 8.6 13.6 2.1 8.3 13.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CHAP PF05257.16 KPI83584.1 - 5e-10 39.8 1.5 5.8e-08 33.2 1.5 2.5 1 1 0 1 1 1 1 CHAP domain Peptidase_C11 PF03415.14 KPI83588.1 - 5e-06 26.2 0.0 6.7e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Clostripain family PKcGMP_CC PF16808.5 KPI83589.1 - 0.59 10.0 10.6 0.47 10.3 0.2 4.0 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NPV_P10 PF05531.12 KPI83589.1 - 1.4 9.4 9.4 4.5 7.8 1.6 4.1 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein TFIIA PF03153.13 KPI83589.1 - 2.3 8.1 27.8 3.9 7.4 10.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ank_4 PF13637.6 KPI83590.1 - 6.4e-23 80.8 1.6 9.7e-06 26.0 0.0 4.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI83590.1 - 2e-21 76.4 0.3 4.2e-10 40.1 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI83590.1 - 2e-14 53.5 2.2 0.00037 20.7 0.4 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KPI83590.1 - 2.4e-12 46.7 1.8 0.0026 18.1 0.2 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KPI83590.1 - 2.8e-11 42.6 2.3 0.06 13.9 0.0 5.3 6 0 0 6 6 6 3 Ankyrin repeat Ad_Cy_reg PF16701.5 KPI83590.1 - 0.0093 15.7 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate cyclase regulatory domain NAD_binding_10 PF13460.6 KPI83592.1 - 0.00046 20.1 0.0 0.45 10.4 0.0 2.3 2 0 0 2 2 2 2 NAD(P)H-binding DUF4844 PF16133.5 KPI83593.1 - 0.083 13.4 0.0 2.1 8.9 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4844) CBF PF03914.17 KPI83594.1 - 2.8e-25 89.3 0.3 4.3e-25 88.7 0.3 1.3 1 0 0 1 1 1 1 CBF/Mak21 family SpoIIE PF07228.12 KPI83595.1 - 2.3e-09 37.5 0.0 2.9e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KPI83595.1 - 0.004 16.8 0.0 0.0097 15.6 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C MethyTransf_Reg PF10119.9 KPI83595.1 - 0.047 14.4 0.0 0.083 13.6 0.0 1.4 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain Tcp10_C PF07202.13 KPI83596.1 - 0.01 15.8 0.3 0.023 14.6 0.1 1.6 2 0 0 2 2 2 0 T-complex protein 10 C-terminus Sod_Fe_C PF02777.18 KPI83596.1 - 0.031 14.4 0.0 0.085 13.0 0.0 1.7 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, C-terminal domain ATP_transf PF09830.9 KPI83597.1 - 0.0035 17.4 0.0 0.011 15.8 0.0 1.9 2 0 0 2 2 2 1 ATP adenylyltransferase DUF2039 PF10217.9 KPI83598.1 - 2.4e-23 82.3 20.5 4.1e-23 81.5 20.5 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Cript PF10235.9 KPI83598.1 - 7.2 7.3 18.4 0.11 13.1 8.2 2.3 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT Peptidase_C2 PF00648.21 KPI83599.1 - 1.4e-23 83.4 0.0 2.2e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease HSBP1 PF06825.12 KPI83599.1 - 6.4 6.7 9.1 45 4.0 0.0 6.4 5 0 0 5 5 5 0 Heat shock factor binding protein 1 Peptidase_C2 PF00648.21 KPI83600.1 - 1.2e-36 126.3 0.0 1.7e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KPI83600.1 - 6.9e-11 42.6 0.2 4.9e-10 39.8 0.0 2.2 2 0 0 2 2 2 1 Calpain large subunit, domain III BOP1NT PF08145.12 KPI83601.1 - 1.5e-79 267.6 7.6 2.6e-79 266.8 7.6 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 KPI83601.1 - 1.4e-18 66.9 4.9 1.6e-07 31.9 0.0 5.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI83601.1 - 2.9e-07 30.7 0.0 0.002 18.4 0.0 4.6 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI83601.1 - 0.025 13.6 0.0 1 8.2 0.0 2.4 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RCC1 PF00415.18 KPI83602.1 - 2.2e-27 95.4 19.0 1.7e-06 28.5 0.1 8.5 7 2 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI83602.1 - 2.1e-07 30.5 23.3 5e-05 23.0 0.5 5.6 5 1 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat LRR_4 PF12799.7 KPI83604.1 - 6.8e-16 58.1 10.5 4.7e-05 23.7 0.5 4.4 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83604.1 - 1.7e-08 34.1 19.0 4.3e-05 23.2 7.1 4.4 1 1 3 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 KPI83604.1 - 0.00038 20.0 0.4 0.021 14.3 0.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KPI83604.1 - 0.15 12.7 13.7 16 6.6 0.1 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 KPI83604.1 - 0.22 11.7 17.4 1.2 9.3 1.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat DNA_ligase_OB_2 PF14743.6 KPI83605.1 - 0.042 13.9 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 DNA ligase OB-like domain Sugarporin_N PF11471.8 KPI83605.1 - 0.53 10.3 3.0 1.6 8.7 0.1 2.7 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension PUF PF00806.19 KPI83607.1 - 2.3e-07 30.1 0.0 0.31 10.8 0.0 6.4 7 0 0 7 7 7 2 Pumilio-family RNA binding repeat Ribosomal_60s PF00428.19 KPI83607.1 - 0.0025 18.3 0.3 0.0025 18.3 0.3 4.2 4 0 0 4 4 4 2 60s Acidic ribosomal protein CPL PF08144.11 KPI83607.1 - 0.15 12.4 9.6 1.5 9.2 0.1 5.0 4 2 1 5 5 5 0 CPL (NUC119) domain T7SS_ESX_EspC PF10824.8 KPI83608.1 - 0.16 12.5 1.3 35 4.9 0.9 2.6 2 0 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm Trans_reg_C PF00486.28 KPI83609.1 - 0.06 13.4 0.3 68 3.7 0.0 3.3 3 0 0 3 3 3 0 Transcriptional regulatory protein, C terminal CAP_GLY PF01302.25 KPI83610.1 - 2.2e-21 75.6 0.4 3.7e-21 74.9 0.4 1.3 1 0 0 1 1 1 1 CAP-Gly domain Glyoxalase_4 PF13669.6 KPI83610.1 - 0.88 9.9 5.3 0.4 11.0 0.9 2.8 3 0 0 3 3 3 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ZapB PF06005.12 KPI83611.1 - 5.3 7.6 7.1 28 5.3 3.0 3.1 3 0 0 3 3 3 0 Cell division protein ZapB Dynein_light PF01221.18 KPI83612.1 - 5.7e-28 97.1 0.5 7e-28 96.8 0.5 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 FKBP_C PF00254.28 KPI83613.1 - 2.6e-10 40.5 0.0 3.3e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase GSG-1 PF07803.11 KPI83613.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 GSG1-like protein FYVE PF01363.21 KPI83615.1 - 9.7e-12 44.9 10.9 4.5e-11 42.7 10.9 2.1 1 1 0 1 1 1 1 FYVE zinc finger zf-CCCH PF00642.24 KPI83616.1 - 1.2e-05 25.1 6.4 1.9e-05 24.4 6.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ComJ PF11033.8 KPI83616.1 - 0.0036 17.0 0.4 0.024 14.3 0.0 2.2 2 0 0 2 2 2 1 Competence protein J (ComJ) Tim29 PF10171.9 KPI83616.1 - 0.18 11.3 1.0 0.5 9.8 0.0 2.1 2 0 0 2 2 2 0 Translocase of the Inner Mitochondrial membrane 29 Pkinase PF00069.25 KPI83617.1 - 4.3e-24 85.3 0.0 7.5e-24 84.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83617.1 - 9.4e-13 48.0 0.0 1.4e-12 47.4 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI83617.1 - 1.1e-09 37.6 0.1 1.4e-09 37.2 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI83617.1 - 0.00012 22.1 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI83617.1 - 0.0084 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KPI83618.1 - 2.3e-26 92.7 0.0 2.9e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83618.1 - 1.6e-15 57.1 0.0 2.1e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI83618.1 - 2.9e-08 32.9 0.1 4e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI83618.1 - 0.0021 18.0 0.4 0.037 14.0 0.3 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KPI83618.1 - 0.22 10.4 0.0 0.32 9.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF45 PF01863.17 KPI83619.1 - 0.24 11.4 1.7 2 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF45 Aldose_epim PF01263.20 KPI83620.1 - 1.5e-55 188.7 0.1 1.8e-55 188.4 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase FA_desaturase PF00487.24 KPI83621.1 - 1.5e-34 120.0 15.1 1.5e-34 120.0 15.1 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 KPI83621.1 - 0.00016 21.8 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DnaJ PF00226.31 KPI83622.1 - 1.8e-19 69.6 3.6 4.3e-19 68.4 3.6 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_19 PF14559.6 KPI83622.1 - 1.6e-09 38.1 31.5 5.5e-05 23.6 2.7 7.1 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KPI83622.1 - 2.5e-06 27.2 20.1 0.074 13.2 0.5 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83622.1 - 0.00037 21.1 23.0 0.0065 17.1 4.7 5.7 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 KPI83622.1 - 0.0022 18.1 1.5 0.0022 18.1 1.5 3.9 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KPI83622.1 - 0.0043 16.7 5.0 0.18 11.5 0.2 4.3 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.28 KPI83622.1 - 0.012 15.5 11.4 8.7 6.4 0.1 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI83622.1 - 0.034 14.2 4.8 0.3 11.2 1.1 3.5 2 2 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 KPI83622.1 - 0.044 14.1 0.6 0.044 14.1 0.6 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83622.1 - 0.1 12.9 16.4 0.61 10.4 0.1 6.0 8 0 0 8 8 5 0 Tetratricopeptide repeat Mhr1 PF12829.7 KPI83622.1 - 0.11 12.6 0.4 44 4.3 0.1 3.3 3 0 0 3 3 3 0 Transcriptional regulation of mitochondrial recombination Alkyl_sulf_dimr PF14863.6 KPI83622.1 - 0.18 12.3 8.7 22 5.5 0.5 3.8 1 1 1 3 3 3 0 Alkyl sulfatase dimerisation ANAPC3 PF12895.7 KPI83622.1 - 0.46 10.7 12.1 0.63 10.3 0.8 4.3 3 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KPI83622.1 - 0.9 10.5 34.0 0.53 11.2 1.3 8.1 6 1 3 9 9 9 0 Tetratricopeptide repeat DUF3675 PF12428.8 KPI83622.1 - 1.1 9.8 2.7 1.6 9.3 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) TPR_17 PF13431.6 KPI83622.1 - 3.6 8.2 10.2 1.4 9.5 0.3 4.5 4 1 0 4 4 3 0 Tetratricopeptide repeat SHMT PF00464.19 KPI83623.1 - 2.2e-178 592.9 0.0 2.7e-178 592.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase LIME1 PF15332.6 KPI83624.1 - 0.29 10.7 6.5 0.037 13.6 1.6 1.9 2 1 0 2 2 2 0 Lck-interacting transmembrane adapter 1 Pkinase PF00069.25 KPI83625.1 - 1.4e-68 231.2 0.0 9.2e-62 208.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83625.1 - 1.7e-36 125.8 0.0 2.2e-34 118.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI83625.1 - 0.00034 19.5 0.0 0.00073 18.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI83625.1 - 0.042 13.8 0.0 0.15 12.0 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI83625.1 - 0.043 13.1 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PSP1 PF04468.12 KPI83626.1 - 8 6.8 6.7 0.95 9.8 0.1 2.8 3 0 0 3 3 3 0 PSP1 C-terminal conserved region F420_oxidored PF03807.17 KPI83627.1 - 8.6e-06 26.3 0.0 8.3e-05 23.1 0.0 2.7 4 0 0 4 4 4 1 NADP oxidoreductase coenzyme F420-dependent Ax_dynein_light PF10211.9 KPI83629.1 - 1.5e-35 122.9 5.2 2.1e-35 122.4 5.2 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain TROVE PF05731.11 KPI83630.1 - 2e-52 178.7 0.0 9.2e-26 90.9 0.0 2.3 2 0 0 2 2 2 2 TROVE domain WD40 PF00400.32 KPI83630.1 - 4.3e-16 59.0 24.4 0.00014 22.6 0.2 10.5 11 0 0 11 11 11 5 WD domain, G-beta repeat DUF4062 PF13271.6 KPI83630.1 - 1.7e-11 44.4 0.0 1e-10 41.8 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) Ge1_WD40 PF16529.5 KPI83630.1 - 0.046 12.7 1.0 33 3.3 0.0 3.9 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L36e PF01158.18 KPI83632.1 - 8e-28 96.5 3.7 9.3e-28 96.3 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e PHD PF00628.29 KPI83634.1 - 0.0017 18.2 2.7 0.0017 18.2 2.7 1.7 2 0 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.6 KPI83634.1 - 0.041 13.8 5.1 0.11 12.4 5.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 NOB1_Zn_bind PF08772.11 KPI83634.1 - 0.052 13.7 3.2 0.12 12.6 3.2 1.6 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zf-HC5HC2H PF13771.6 KPI83634.1 - 0.25 11.6 2.3 0.22 11.8 0.6 1.7 2 0 0 2 2 2 0 PHD-like zinc-binding domain DZR PF12773.7 KPI83634.1 - 0.36 10.9 4.4 0.94 9.6 4.4 1.7 1 0 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 KPI83634.1 - 0.47 10.4 7.5 0.29 11.1 3.5 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) NYD-SP28_assoc PF14775.6 KPI83635.1 - 0.098 12.8 8.7 0.43 10.7 1.2 2.4 1 1 1 2 2 2 0 Sperm tail C-terminal domain Exonuc_VII_L PF02601.15 KPI83635.1 - 1 8.9 8.0 0.78 9.2 5.2 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit PRKG1_interact PF15898.5 KPI83635.1 - 1.9 9.4 16.2 0.13 13.2 1.3 3.4 2 1 2 4 4 4 0 cGMP-dependent protein kinase interacting domain UPF0242 PF06785.11 KPI83635.1 - 2.4 8.2 8.3 3 7.9 6.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus OmpH PF03938.14 KPI83635.1 - 5.1 7.4 13.0 0.3 11.4 6.9 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Atg14 PF10186.9 KPI83635.1 - 8.2 5.4 11.5 0.94 8.5 7.2 1.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATP11 PF06644.11 KPI83636.1 - 4.2e-22 79.2 0.9 7e-22 78.5 0.9 1.3 1 1 0 1 1 1 1 ATP11 protein Lysine_decarbox PF03641.14 KPI83637.1 - 1.2e-11 44.9 0.0 1.6e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 KPI83637.1 - 3.5e-10 39.7 0.1 2.9e-09 36.7 0.1 2.0 1 1 0 1 1 1 1 SLOG cluster4 family GGDEF_2 PF17853.1 KPI83637.1 - 0.15 12.3 0.1 0.34 11.2 0.1 1.5 1 0 0 1 1 1 0 GGDEF-like domain UBX PF00789.20 KPI83638.1 - 5.4e-08 32.9 0.0 1.2e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain eIF3_subunit PF08597.10 KPI83638.1 - 0.048 13.6 19.7 0.068 13.1 19.7 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Thioredoxin_7 PF13899.6 KPI83638.1 - 0.051 13.8 0.3 0.25 11.6 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like ARGLU PF15346.6 KPI83638.1 - 0.087 12.7 32.6 0.15 12.0 32.6 1.3 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Thioredoxin_2 PF13098.6 KPI83638.1 - 0.092 13.2 0.1 0.26 11.8 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like domain Plasmodium_Vir PF05795.11 KPI83638.1 - 0.37 10.2 2.1 0.49 9.8 2.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Nop53 PF07767.11 KPI83638.1 - 1.7 8.0 23.0 2.1 7.6 23.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Asp-B-Hydro_N PF05279.11 KPI83638.1 - 2.9 7.9 19.7 4.1 7.4 19.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region NARP1 PF12569.8 KPI83638.1 - 3.4 6.5 16.6 4.9 5.9 16.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Imm70 PF15601.6 KPI83639.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 70 U3_assoc_6 PF08640.11 KPI83640.1 - 1.5e-17 63.4 0.0 5.1e-16 58.5 0.0 2.7 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 DUF3347 PF11827.8 KPI83640.1 - 0.044 14.0 0.4 0.044 14.0 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) NRDE-2 PF08424.10 KPI83640.1 - 0.11 11.6 1.7 0.14 11.2 0.3 1.9 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference AsnA PF03590.15 KPI83642.1 - 1.7e-94 315.8 0.0 2.1e-94 315.6 0.0 1.1 1 0 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.20 KPI83642.1 - 0.00062 18.9 0.1 0.0042 16.2 0.0 2.1 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) Thump_like PF18096.1 KPI83642.1 - 0.05 13.5 0.2 0.17 11.8 0.0 2.0 3 0 0 3 3 3 0 THUMP domain-like Exo_endo_phos PF03372.23 KPI83645.1 - 1.4e-06 28.0 0.0 5.6e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family XRN_N PF03159.18 KPI83645.1 - 2.9e-05 23.6 0.0 0.0001 21.8 0.0 1.8 2 1 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Peptidase_M20 PF01546.28 KPI83646.1 - 2.5e-20 73.1 0.2 3.3e-20 72.7 0.2 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI83646.1 - 1.7e-06 27.9 0.3 3.9e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain DUF4192 PF13830.6 KPI83646.1 - 0.0019 18.3 2.1 0.062 13.3 2.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4192) FYRC PF05965.14 KPI83648.1 - 0.025 14.8 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 F/Y rich C-terminus Zn-ribbon_8 PF09723.10 KPI83648.1 - 6.6 6.9 5.8 26 5.1 5.7 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Ribosomal_60s PF00428.19 KPI83650.1 - 3.5e-26 91.6 13.1 4.1e-26 91.4 13.1 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein CPSF_A PF03178.15 KPI83651.1 - 7.7e-53 179.9 0.0 5.6e-52 177.0 0.0 2.4 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.9 KPI83651.1 - 0.0004 19.1 0.0 0.00082 18.1 0.0 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF3808 PF10300.9 KPI83654.1 - 2.5e-28 99.1 9.1 1.8e-27 96.3 6.9 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_12 PF13424.6 KPI83654.1 - 1.6e-06 28.3 0.4 0.034 14.4 0.1 3.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI83654.1 - 0.00013 21.9 4.5 3.1 8.1 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83654.1 - 0.0017 18.8 0.4 19 5.9 0.1 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat YL1 PF05764.13 KPI83654.1 - 0.013 15.6 7.4 0.024 14.8 7.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein SR-25 PF10500.9 KPI83654.1 - 0.14 11.8 6.6 0.24 11.0 6.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Terminase_6 PF03237.15 KPI83654.1 - 0.17 11.5 1.3 0.44 10.2 1.3 1.6 1 0 0 1 1 1 0 Terminase-like family TPR_16 PF13432.6 KPI83654.1 - 0.21 12.3 1.9 14 6.5 0.6 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83654.1 - 0.83 9.9 5.7 10 6.4 1.1 4.3 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 KPI83654.1 - 1.5 8.5 7.6 0.28 10.9 0.2 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 KPI83654.1 - 1.8 9.4 5.8 14 6.6 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat HNH_4 PF13395.6 KPI83655.1 - 0.18 11.8 0.0 0.61 10.0 0.0 1.9 2 0 0 2 2 2 0 HNH endonuclease SnoaL_2 PF12680.7 KPI83656.1 - 9.9e-05 22.9 0.2 0.00016 22.3 0.2 1.7 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 KPI83656.1 - 0.0093 16.2 1.3 0.097 12.9 0.0 2.5 2 1 1 3 3 3 1 SnoaL-like domain SnoaL PF07366.12 KPI83656.1 - 0.042 13.7 0.1 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase ATP-synt_C PF00137.21 KPI83657.1 - 5.9e-20 71.4 41.8 4.7e-12 46.1 11.3 2.7 3 0 0 3 3 3 2 ATP synthase subunit C Metallophos PF00149.28 KPI83659.1 - 0.0034 17.9 0.1 0.036 14.6 0.0 2.5 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase ATP-grasp_5 PF13549.6 KPI83659.1 - 0.2 11.1 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Tctex-1 PF03645.13 KPI83660.1 - 3.2e-23 81.9 0.5 3.5e-23 81.8 0.5 1.0 1 0 0 1 1 1 1 Tctex-1 family TPR_2 PF07719.17 KPI83661.1 - 8.1e-24 81.8 21.2 0.0017 18.3 0.0 10.4 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83661.1 - 6.9e-15 54.2 13.7 0.1 12.5 0.0 9.3 11 0 0 11 11 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83661.1 - 1.7e-14 54.1 33.6 0.00026 21.4 0.2 8.7 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83661.1 - 6.7e-14 51.4 34.7 0.0011 19.7 0.9 10.2 6 4 6 12 12 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83661.1 - 6e-10 39.3 39.9 0.1 12.9 0.5 9.2 8 2 1 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83661.1 - 2.1e-08 34.7 35.3 0.0054 17.3 2.9 8.0 6 2 2 10 10 9 6 Tetratricopeptide repeat TPR_9 PF13371.6 KPI83661.1 - 2.4e-07 30.8 17.8 0.00087 19.4 1.8 6.0 3 1 2 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83661.1 - 8.5e-07 29.1 32.0 0.021 15.0 1.0 6.1 7 1 0 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KPI83661.1 - 2.7e-06 27.2 3.6 0.4 11.0 0.9 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.17 KPI83661.1 - 6.8e-05 23.3 4.2 6.8e-05 23.3 4.2 4.2 2 1 0 3 3 3 1 Bacterial transcriptional activator domain TPR_6 PF13174.6 KPI83661.1 - 0.00026 21.4 20.3 3.5 8.4 0.0 8.7 11 0 0 11 11 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI83661.1 - 0.00065 19.7 1.8 0.14 12.3 0.4 3.7 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 KPI83661.1 - 0.00085 19.5 14.7 0.71 10.4 0.4 7.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 KPI83661.1 - 0.0012 18.2 15.1 0.0024 17.2 2.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.8 KPI83661.1 - 0.0039 16.2 2.2 0.056 12.3 0.1 2.4 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 TPR_11 PF13414.6 KPI83661.1 - 0.0048 16.5 11.6 7.6 6.3 0.0 5.8 3 2 3 6 6 6 1 TPR repeat TPR_7 PF13176.6 KPI83661.1 - 0.14 12.2 10.9 36 4.7 0.0 6.5 5 2 2 7 7 6 0 Tetratricopeptide repeat PRP38_assoc PF12871.7 KPI83661.1 - 0.16 12.6 7.3 0.51 11.0 7.3 1.9 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SMC_N PF02463.19 KPI83662.1 - 4.9e-58 196.2 0.0 1.2e-57 194.9 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KPI83662.1 - 1.1e-12 48.3 0.8 7.4e-12 45.6 0.1 2.9 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KPI83662.1 - 2.3e-12 47.4 2.7 5.9e-06 26.3 1.4 3.0 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI83662.1 - 4e-10 40.5 12.6 4e-10 40.5 12.6 6.2 2 2 2 4 4 4 1 AAA domain AAA_15 PF13175.6 KPI83662.1 - 4.8e-05 23.2 18.6 0.0074 16.0 9.0 4.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 KPI83662.1 - 0.00023 20.9 0.0 0.00063 19.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DHR10 PF18595.1 KPI83662.1 - 0.0095 16.0 3.1 0.0095 16.0 3.1 9.7 4 3 5 9 9 9 1 Designed helical repeat protein 10 domain ABC_tran PF00005.27 KPI83662.1 - 0.035 14.6 0.0 0.035 14.6 0.0 6.9 4 3 2 6 6 6 0 ABC transporter eRF1_1 PF03463.15 KPI83662.1 - 0.048 13.7 1.8 0.24 11.4 1.8 2.3 1 0 0 1 1 1 0 eRF1 domain 1 Pkinase PF00069.25 KPI83663.1 - 2.5e-69 233.6 0.0 3.2e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83663.1 - 5.8e-52 176.5 0.0 8.8e-52 175.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MORN PF02493.20 KPI83663.1 - 2.8e-39 130.7 49.6 3.5e-08 32.9 3.9 8.8 8 0 0 8 8 8 8 MORN repeat Pkinase_fungal PF17667.1 KPI83663.1 - 0.00018 20.4 0.3 0.00042 19.2 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 KPI83663.1 - 0.021 13.8 0.0 0.041 12.8 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KPI83663.1 - 0.026 13.9 0.0 0.056 12.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KPI83663.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI83663.1 - 0.23 11.1 0.0 0.79 9.3 0.0 1.7 1 1 1 2 2 2 0 RIO1 family TSC21 PF15217.6 KPI83665.1 - 0.003 17.5 1.9 0.081 12.9 0.2 2.0 1 1 1 2 2 2 2 TSC21 family IPPT PF01715.17 KPI83666.1 - 0.022 14.6 4.0 0.047 13.5 1.6 2.4 3 0 0 3 3 3 0 IPP transferase TetR_C_24 PF17932.1 KPI83666.1 - 0.26 11.6 2.5 0.46 10.8 0.1 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF1451 PF07295.11 KPI83666.1 - 0.26 11.3 3.8 0.2 11.7 1.3 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain DUF445 PF04286.12 KPI83666.1 - 0.49 10.2 7.3 0.39 10.5 4.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Mito_fiss_reg PF05308.11 KPI83666.1 - 0.76 9.8 6.4 0.14 12.3 0.7 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator ARGLU PF15346.6 KPI83666.1 - 1.6 8.6 8.0 0.68 9.8 4.7 2.1 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 DNA_pol_A PF00476.20 KPI83667.1 - 9.3e-41 140.1 0.0 9.9e-40 136.7 0.0 2.4 2 1 0 2 2 2 1 DNA polymerase family A Endomucin PF07010.12 KPI83667.1 - 3.1 7.7 16.0 0.16 11.9 8.5 2.2 2 0 0 2 2 2 0 Endomucin GSH_synth_ATP PF03917.17 KPI83668.1 - 4e-70 236.5 0.0 5.2e-70 236.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KPI83668.1 - 7.4e-29 100.2 0.0 1.5e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Pacs-1 PF10254.9 KPI83669.1 - 0.042 12.8 0.0 0.18 10.7 0.0 2.1 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein VSP PF03302.13 KPI83671.1 - 0.095 11.5 6.0 0.18 10.6 6.1 1.5 1 1 0 1 1 1 0 Giardia variant-specific surface protein CDC50 PF03381.15 KPI83673.1 - 1.2e-63 215.3 0.0 1.9e-63 214.6 0.0 1.3 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family LCAT PF02450.15 KPI83674.1 - 1.9e-52 178.7 0.0 3e-40 138.6 0.0 2.2 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 KPI83674.1 - 0.0066 17.1 1.5 0.013 16.1 0.1 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Motile_Sperm PF00635.26 KPI83675.1 - 6.7e-12 45.2 0.0 1.1e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain FAM199X PF15814.5 KPI83675.1 - 0.28 10.2 2.9 0.39 9.7 2.4 1.3 1 1 0 1 1 1 0 Protein family FAM199X SHS2_Rpb7-N PF03876.17 KPI83676.1 - 1.4e-24 86.2 0.3 2.9e-24 85.2 0.0 1.7 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 KPI83676.1 - 1.3e-11 44.9 0.0 7.5e-10 39.1 0.0 2.6 2 1 0 2 2 2 1 RNA polymerase III subunit Rpc25 eIF2_C PF09173.11 KPI83677.1 - 1.2e-26 92.8 0.1 2.5e-26 91.7 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 KPI83677.1 - 0.0001 22.6 1.5 0.00026 21.3 1.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 KPI83677.1 - 0.043 13.8 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain PAP2 PF01569.21 KPI83680.1 - 1.5e-17 63.7 3.2 1.5e-17 63.7 3.2 2.8 3 1 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 KPI83680.1 - 3e-05 23.8 1.9 3e-05 23.8 1.9 2.3 2 0 0 2 2 2 1 PAP2 superfamily ERG4_ERG24 PF01222.17 KPI83683.1 - 1.1e-125 419.8 1.8 1.3e-125 419.5 1.8 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KPI83683.1 - 7.4e-06 25.7 0.1 1.4e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KPI83683.1 - 0.0023 18.3 0.0 0.0023 18.3 0.0 2.9 4 0 0 4 4 4 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KPI83683.1 - 0.014 15.8 0.3 0.052 13.9 0.0 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase EamA PF00892.20 KPI83684.1 - 0.0018 18.4 9.8 0.0037 17.4 9.8 1.5 1 1 0 1 1 1 1 EamA-like transporter family NAD_binding_1 PF00175.21 KPI83685.1 - 3e-19 69.7 0.0 5.2e-17 62.5 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KPI83685.1 - 1.7e-13 50.8 0.0 2.9e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KPI83685.1 - 8.7e-05 22.7 0.0 0.0003 20.9 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Nsp1_C PF05064.13 KPI83686.1 - 8.2e-06 25.6 3.9 8.2e-06 25.6 3.9 2.1 2 1 0 2 2 2 1 Nsp1-like C-terminal region Lipoprotein_20 PF13942.6 KPI83686.1 - 0.0077 16.2 1.9 0.0099 15.8 1.9 1.3 1 0 0 1 1 1 1 YfhG lipoprotein Spc7 PF08317.11 KPI83686.1 - 0.0097 14.8 4.9 0.014 14.3 4.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Arfaptin PF06456.13 KPI83686.1 - 0.011 15.3 1.3 0.018 14.6 1.3 1.4 1 0 0 1 1 1 0 Arfaptin-like domain CENP-F_leu_zip PF10473.9 KPI83686.1 - 0.015 15.3 6.1 0.13 12.3 0.7 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ORF11CD3 PF10549.9 KPI83686.1 - 0.038 14.1 0.2 0.53 10.5 0.0 2.8 2 1 1 3 3 3 0 ORF11CD3 domain DUF4530 PF15039.6 KPI83686.1 - 0.089 12.9 3.5 0.12 12.5 2.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4530) DUF724 PF05266.14 KPI83686.1 - 0.15 11.8 3.4 0.27 11.0 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Seryl_tRNA_N PF02403.22 KPI83686.1 - 0.29 11.4 2.2 1.1 9.5 2.2 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain JAKMIP_CC3 PF16034.5 KPI83686.1 - 0.68 9.8 8.2 1 9.3 8.2 1.2 1 0 0 1 1 1 0 JAKMIP CC3 domain Mod_r PF07200.13 KPI83686.1 - 5 7.2 10.2 4.7 7.3 0.7 2.4 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein PP2C PF00481.21 KPI83689.1 - 6.2e-34 117.8 0.1 4.7e-29 101.8 0.0 2.5 2 0 0 2 2 2 2 Protein phosphatase 2C zf-UBP PF02148.19 KPI83689.1 - 0.051 13.9 10.3 0.2 12.0 10.3 2.1 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 KPI83689.1 - 0.22 11.3 3.1 0.48 10.2 3.1 1.5 1 0 0 1 1 1 0 Variant UBP zinc finger Peptidase_C1 PF00112.23 KPI83691.1 - 6.4e-69 232.4 6.6 1e-68 231.7 6.6 1.3 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.8 KPI83691.1 - 5.7e-15 55.3 7.6 1.5e-14 54.0 7.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.12 KPI83691.1 - 1.9e-05 25.0 0.4 3.9e-05 24.0 0.4 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KPI83691.1 - 0.00026 19.9 3.5 0.012 14.4 0.1 2.6 3 0 0 3 3 3 2 Peptidase C1-like family SLR1-BP PF07333.12 KPI83691.1 - 0.0012 19.3 1.4 0.0048 17.3 1.4 2.0 1 0 0 1 1 1 1 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) PAP_assoc PF03828.19 KPI83692.1 - 6.5e-14 51.9 0.0 1.9e-13 50.4 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase TPR_11 PF13414.6 KPI83693.1 - 3e-10 39.6 1.7 0.0011 18.6 0.6 4.1 4 0 0 4 4 4 2 TPR repeat TPR_2 PF07719.17 KPI83693.1 - 7.6e-08 31.9 4.9 0.00085 19.3 0.1 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83693.1 - 5.6e-07 29.3 3.1 0.00043 20.3 0.0 4.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83693.1 - 6.9e-06 25.7 4.2 0.0081 16.0 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI83693.1 - 8.6e-06 25.8 3.9 0.0041 17.4 0.0 4.3 6 0 0 6 6 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83693.1 - 2.4e-05 24.5 0.8 0.0045 17.3 0.1 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KPI83693.1 - 0.00014 21.6 1.0 0.0015 18.3 0.1 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83693.1 - 0.002 18.8 0.3 7.8 7.6 0.1 4.1 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83693.1 - 0.006 17.1 1.3 8.5 7.0 0.4 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KPI83693.1 - 0.0067 17.0 3.4 2.9 8.7 0.0 3.4 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_21 PF09976.9 KPI83693.1 - 0.0097 15.6 1.4 0.011 15.5 0.3 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 KPI83693.1 - 0.012 15.8 0.3 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KPI83693.1 - 0.02 14.9 0.8 1.1 9.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83693.1 - 0.027 15.1 0.2 2.5 8.8 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TOM20_plant PF06552.12 KPI83693.1 - 0.082 12.7 1.4 2.1 8.1 0.0 2.6 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Sel1 PF08238.12 KPI83693.1 - 0.5 11.1 3.4 11 6.9 0.1 3.7 3 0 0 3 3 3 0 Sel1 repeat TBP PF00352.21 KPI83694.1 - 4.3e-39 132.3 0.2 2.6e-20 72.2 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) Fip1 PF05182.13 KPI83694.1 - 4.9 6.7 6.8 8.3 6.0 6.8 1.3 1 0 0 1 1 1 0 Fip1 motif Cation_efflux PF01545.21 KPI83695.1 - 4.6e-32 111.4 8.0 8.7e-20 71.3 1.7 2.2 2 0 0 2 2 2 2 Cation efflux family PDZ_2 PF13180.6 KPI83696.1 - 9e-06 25.9 0.0 9.6e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KPI83696.1 - 1.2e-05 25.1 0.6 2.6e-05 24.0 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KPI83696.1 - 0.0026 18.1 0.0 0.0062 16.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Dynamin_M PF01031.20 KPI83696.1 - 0.0052 16.0 0.0 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin central region DUF641 PF04859.12 KPI83696.1 - 0.031 14.6 1.2 0.87 9.9 0.0 3.1 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) TgMIC1 PF11476.8 KPI83698.1 - 0.0073 16.1 0.2 0.0085 15.8 0.2 1.1 1 0 0 1 1 1 1 Toxoplasma gondii micronemal protein 1 TgMIC1 VirB3 PF05101.13 KPI83698.1 - 3.6 7.9 6.0 4.2 7.7 1.9 2.0 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein PAP2 PF01569.21 KPI83699.1 - 2.6e-25 88.8 1.6 2.6e-25 88.8 1.6 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KPI83699.1 - 5.6e-05 22.9 2.7 0.00019 21.2 0.4 2.5 2 0 0 2 2 2 1 PAP2 superfamily Papilloma_E5A PF05776.12 KPI83700.1 - 2 8.8 5.0 0.44 11.0 1.6 1.5 2 0 0 2 2 2 0 Papillomavirus E5A protein DEAD PF00270.29 KPI83702.1 - 1e-32 113.3 0.0 2.1e-16 60.2 0.0 2.6 2 1 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI83702.1 - 1.9e-22 79.7 0.1 2.4e-21 76.1 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI83702.1 - 7.5e-05 22.8 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KPI83702.1 - 0.039 14.2 0.1 0.63 10.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain COG4 PF08318.12 KPI83703.1 - 1.7e-46 158.8 0.1 6.9e-46 156.9 0.0 2.0 2 1 0 2 2 2 1 COG4 transport protein RINT1_TIP1 PF04437.13 KPI83703.1 - 0.085 11.7 0.2 0.19 10.5 0.2 1.6 1 0 0 1 1 1 0 RINT-1 / TIP-1 family DUF4349 PF14257.6 KPI83703.1 - 0.84 9.0 10.1 0.21 11.0 0.5 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) Surp PF01805.20 KPI83704.1 - 3.7e-10 39.7 0.0 6.2e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Surp module Macoilin PF09726.9 KPI83704.1 - 0.65 8.5 3.4 1 7.9 3.4 1.2 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 KPI83704.1 - 3.2 6.8 21.1 0.32 10.1 3.8 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein SMODS PF18144.1 KPI83705.1 - 0.1 12.8 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Kinesin PF00225.23 KPI83706.1 - 4.1e-90 302.1 0.1 7.6e-90 301.2 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI83706.1 - 5.9e-24 84.7 0.0 3e-23 82.4 0.0 2.3 1 1 0 1 1 1 1 Microtubule binding SesA PF17107.5 KPI83706.1 - 0.16 12.1 6.2 0.8 9.9 2.6 3.2 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases GldM_N PF12081.8 KPI83706.1 - 0.41 10.7 5.7 1.2 9.1 5.7 1.8 1 0 0 1 1 1 0 GldM N-terminal domain MIEAP PF16026.5 KPI83706.1 - 0.49 10.6 8.4 1.5 9.0 8.4 1.8 1 0 0 1 1 1 0 Mitochondria-eating protein FapA PF03961.13 KPI83706.1 - 4.3 5.8 6.8 0.78 8.3 2.3 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A PTH2 PF01981.16 KPI83706.1 - 6.7 7.0 9.4 12 6.2 6.5 2.9 2 1 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 CorA PF01544.18 KPI83707.1 - 1.5e-20 73.7 0.0 1.9e-20 73.3 0.0 1.3 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DnaJ_C PF01556.18 KPI83708.1 - 4.9e-33 114.3 0.0 7.1e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI83708.1 - 1.3e-16 60.4 0.0 2.4e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KPI83708.1 - 3.8e-13 49.6 13.0 6.3e-13 48.9 13.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI83708.1 - 5.4e-05 23.1 7.4 0.059 13.3 0.9 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HTH_16 PF12645.7 KPI83708.1 - 0.092 12.8 0.2 0.49 10.5 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain HypA PF01155.19 KPI83708.1 - 0.41 10.7 10.9 2.7 8.0 1.6 2.3 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 KPI83708.1 - 0.52 10.5 7.7 1.1 9.4 0.3 2.3 1 1 1 2 2 2 0 zinc RING finger of MSL2 TackOD1 PF18551.1 KPI83708.1 - 0.52 9.9 7.3 0.19 11.4 0.5 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-RING_4 PF14570.6 KPI83708.1 - 0.91 9.4 9.9 4.9 7.0 1.8 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 KPI83708.1 - 1.2 9.1 8.9 0.12 12.3 0.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Kelch_3 PF13415.6 KPI83709.1 - 2.5e-05 24.5 4.4 0.00051 20.2 0.2 5.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_4 PF13418.6 KPI83709.1 - 0.00016 21.6 7.3 0.16 12.0 0.0 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Rb_C PF08934.10 KPI83710.1 - 1.1 9.0 4.1 0.9 9.3 0.3 2.4 2 0 0 2 2 2 0 Rb C-terminal domain DNA_methylase PF00145.17 KPI83711.1 - 1.3e-42 146.4 0.0 9e-21 74.6 0.0 4.1 3 1 0 3 3 3 3 C-5 cytosine-specific DNA methylase ANAPC4_WD40 PF12894.7 KPI83712.1 - 0.0082 16.4 0.0 9.8 6.6 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI83712.1 - 0.02 15.7 0.1 26 5.9 0.0 3.8 2 1 0 2 2 2 0 WD domain, G-beta repeat TPR_7 PF13176.6 KPI83714.1 - 0.048 13.7 0.1 16 5.8 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI83714.1 - 0.62 10.3 2.3 12 6.3 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83714.1 - 1.3 10.1 16.9 51 5.1 0.1 6.4 5 0 0 5 5 5 0 Tetratricopeptide repeat zinc_ribbon_16 PF17034.5 KPI83715.1 - 1.5e-06 28.4 15.1 8.1e-06 26.1 15.1 2.1 1 1 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 KPI83715.1 - 0.013 15.1 12.8 0.033 13.8 12.8 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 KPI83715.1 - 0.26 11.7 8.1 0.85 10.0 8.1 1.9 1 0 0 1 1 1 0 Ring finger domain SMBP PF16785.5 KPI83716.1 - 0.025 14.8 2.6 0.14 12.4 0.1 2.4 2 0 0 2 2 2 0 Small metal-binding protein CotJB PF12652.7 KPI83716.1 - 0.029 14.6 2.7 0.066 13.4 1.5 2.3 2 1 0 2 2 2 0 CotJB protein MamL-1 PF09596.10 KPI83716.1 - 0.14 12.4 0.9 0.54 10.5 0.4 2.3 2 0 0 2 2 2 0 MamL-1 domain SET PF00856.28 KPI83717.1 - 9.5e-12 45.6 0.2 0.00022 21.7 0.3 3.5 1 1 1 2 2 2 2 SET domain SAF PF08666.12 KPI83717.1 - 0.088 13.5 0.0 25 5.6 0.0 2.4 2 0 0 2 2 2 0 SAF domain Rrn6 PF10214.9 KPI83717.1 - 6.7 5.1 11.8 11 4.4 8.9 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor DNA_pol_B_thumb PF14791.6 KPI83718.1 - 5.4e-20 71.3 0.0 1.2e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 KPI83718.1 - 7.2e-19 68.1 0.0 1.6e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 KPI83718.1 - 1.8e-13 50.6 0.3 1.2e-11 44.8 0.1 2.6 1 1 1 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 KPI83718.1 - 2.6e-13 49.6 0.0 1.5e-12 47.2 0.0 2.3 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda HHH_5 PF14520.6 KPI83718.1 - 6.6e-05 23.4 0.0 0.0028 18.2 0.0 2.6 1 1 0 2 2 2 1 Helix-hairpin-helix domain DMP12 PF16779.5 KPI83718.1 - 0.038 14.0 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 DNA-mimic protein HHH_3 PF12836.7 KPI83718.1 - 0.11 12.7 0.1 27 5.1 0.0 3.0 2 1 1 3 3 3 0 Helix-hairpin-helix motif DNA_pol_B_palm PF14792.6 KPI83719.1 - 2.7e-25 88.8 0.0 8.2e-25 87.2 0.0 1.9 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 KPI83719.1 - 4e-15 55.7 1.5 3.3e-14 52.8 1.5 2.5 1 1 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 KPI83719.1 - 2.1e-06 27.4 0.1 4.5e-05 23.2 0.1 2.7 2 1 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 KPI83719.1 - 6.3e-05 23.3 0.1 0.091 13.1 0.0 3.7 3 0 0 3 3 3 2 Helix-hairpin-helix domain HHH_5 PF14520.6 KPI83719.1 - 0.0023 18.5 1.9 0.033 14.8 0.0 3.5 4 0 0 4 4 4 1 Helix-hairpin-helix domain Lactamase_B_2 PF12706.7 KPI83720.1 - 4.2e-06 26.4 0.5 0.0017 17.9 0.0 2.6 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 KPI83720.1 - 0.0024 17.5 0.1 0.024 14.3 0.0 2.4 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B PF00753.27 KPI83720.1 - 1.3 9.0 4.4 4.4 7.2 2.1 2.5 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily zf-RING_2 PF13639.6 KPI83723.1 - 1.4e-11 44.5 10.7 1.4e-11 44.5 10.7 2.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI83723.1 - 9e-09 35.0 7.6 9e-09 35.0 7.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KPI83723.1 - 1.6e-07 30.9 3.9 1.6e-07 30.9 3.9 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 KPI83723.1 - 5.3e-07 29.8 11.8 5.4e-07 29.8 9.7 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KPI83723.1 - 3.3e-06 26.8 6.6 3.3e-06 26.8 6.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI83723.1 - 1.4e-05 24.9 6.4 1.4e-05 24.9 6.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI83723.1 - 3.3e-05 23.8 2.6 0.00012 22.0 2.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KPI83723.1 - 9.1e-05 22.3 6.8 9.1e-05 22.3 6.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KPI83723.1 - 0.0014 18.6 5.1 0.0019 18.2 3.5 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KPI83723.1 - 0.091 12.4 5.9 0.27 10.9 5.9 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KPI83723.1 - 7.9 6.7 8.5 95 3.3 8.5 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain C2 PF00168.30 KPI83727.1 - 5.2e-15 55.6 0.0 8.2e-13 48.5 0.0 2.4 2 0 0 2 2 2 2 C2 domain SMP_LBD PF17047.5 KPI83727.1 - 2.7e-13 49.8 0.0 4.7e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain RRM_1 PF00076.22 KPI83729.1 - 7.8e-12 44.8 0.0 1.2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aha1_N PF09229.11 KPI83730.1 - 2.1e-26 92.8 1.6 3.1e-26 92.2 1.6 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 KPI83730.1 - 5.2e-20 71.9 0.0 3.5e-19 69.3 0.0 2.2 2 1 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein DUF3231 PF11553.8 KPI83730.1 - 0.13 11.9 0.0 0.52 9.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) Fra10Ac1 PF09725.9 KPI83730.1 - 4.4 7.4 5.4 12 6.0 0.5 2.6 2 1 1 3 3 3 0 Folate-sensitive fragile site protein Fra10Ac1 Amino_oxidase PF01593.24 KPI83731.1 - 1.2e-09 38.0 0.0 4.7e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KPI83731.1 - 1.9e-08 34.4 0.2 4.6e-08 33.2 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KPI83731.1 - 0.00058 19.2 0.0 0.00099 18.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KPI83731.1 - 0.0011 18.4 0.1 0.0016 17.8 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI83731.1 - 0.005 15.6 0.2 0.007 15.1 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 KPI83731.1 - 0.034 13.2 0.3 0.056 12.5 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 KPI83731.1 - 0.05 13.2 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 KPI83731.1 - 0.11 11.7 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Thi4 family MCRA PF06100.11 KPI83731.1 - 0.14 11.0 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 MCRA family GIDA PF01134.22 KPI83731.1 - 0.14 11.2 0.1 0.24 10.4 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A RRM_1 PF00076.22 KPI83732.1 - 1.7e-31 107.9 0.0 2.5e-18 65.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI83732.1 - 0.00011 22.1 0.0 0.089 12.8 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KPI83732.1 - 0.0021 17.9 0.0 0.14 12.1 0.0 2.5 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 KPI83732.1 - 0.0027 17.8 0.0 0.02 15.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 KPI83732.1 - 0.082 12.5 0.0 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 KPI83732.1 - 0.11 12.2 0.0 17 5.1 0.1 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated EF-hand_7 PF13499.6 KPI83734.1 - 5.6e-09 36.3 0.0 0.00018 21.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KPI83734.1 - 2.4e-08 34.2 0.0 0.049 14.0 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KPI83734.1 - 2.7e-08 33.5 0.0 0.049 13.5 0.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KPI83734.1 - 2.2e-07 30.3 0.0 0.028 14.3 0.0 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KPI83734.1 - 5e-05 22.6 0.0 0.25 11.0 0.0 3.5 3 0 0 3 3 3 1 EF hand DUF2267 PF10025.9 KPI83734.1 - 0.04 14.2 0.2 6.9 7.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) GPHH PF16905.5 KPI83734.1 - 0.049 13.4 0.0 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Retrotran_gag_2 PF14223.6 KPI83734.1 - 0.13 11.9 0.0 15 5.3 0.0 2.5 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type AsiA PF09010.10 KPI83734.1 - 0.15 12.2 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Anti-Sigma Factor A HEAT PF02985.22 KPI83735.1 - 7.3e-16 56.9 12.9 0.13 12.6 0.0 10.6 11 0 0 11 11 11 5 HEAT repeat HEAT_2 PF13646.6 KPI83735.1 - 9e-13 48.4 10.1 4.5e-06 27.0 0.1 6.1 4 1 3 7 7 7 5 HEAT repeats Adaptin_N PF01602.20 KPI83735.1 - 3.3e-05 22.6 1.4 0.022 13.3 0.1 3.1 3 0 0 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 KPI83735.1 - 0.001 19.1 3.8 0.025 14.6 0.2 4.1 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 KPI83735.1 - 2 8.8 5.8 32 4.9 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion ABC2_membrane PF01061.24 KPI83738.1 - 4.5e-41 140.6 16.9 6.8e-41 140.0 16.9 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KPI83738.1 - 2.6e-19 70.1 0.0 4.2e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 KPI83738.1 - 0.00099 19.5 0.0 0.0019 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI83738.1 - 0.0051 17.1 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KPI83738.1 - 0.01 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 KPI83738.1 - 0.013 16.0 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KPI83738.1 - 0.016 14.9 0.5 0.033 13.9 0.5 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI83738.1 - 0.023 14.4 0.3 0.052 13.3 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 KPI83738.1 - 0.025 14.4 0.0 5.8 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 KPI83738.1 - 0.053 13.7 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KPI83738.1 - 0.055 13.9 0.0 0.69 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 KPI83738.1 - 0.058 13.9 0.0 0.86 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 KPI83738.1 - 0.072 12.5 0.0 8.4 5.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PRK PF00485.18 KPI83738.1 - 0.076 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 KPI83738.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KPI83738.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 KPI83738.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 KPI83738.1 - 0.15 12.1 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 KPI83738.1 - 0.2 11.4 0.4 0.43 10.3 0.4 1.5 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.7 KPI83738.1 - 0.71 8.9 16.4 0.057 12.5 11.6 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein FAM176 PF14851.6 KPI83739.1 - 0.01 15.5 1.7 0.084 12.5 0.0 2.3 1 1 1 2 2 2 0 FAM176 family Orthoreo_P10 PF07204.11 KPI83739.1 - 0.02 14.9 0.1 0.042 13.8 0.1 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Alpha_GJ PF03229.13 KPI83739.1 - 0.088 13.4 0.6 0.088 13.4 0.6 2.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J Shisa PF13908.6 KPI83739.1 - 0.14 12.4 0.2 0.14 12.4 0.2 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator FAM163 PF15069.6 KPI83739.1 - 0.15 12.5 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 FAM163 family Ctr PF04145.15 KPI83739.1 - 0.31 11.7 1.0 2 9.0 1.0 2.2 1 1 0 1 1 1 0 Ctr copper transporter family TMEM119 PF15724.5 KPI83739.1 - 2.3 8.2 8.6 0.082 13.0 2.4 1.6 2 0 0 2 2 2 0 TMEM119 family CDC45 PF02724.14 KPI83739.1 - 3.8 5.7 6.7 5.2 5.2 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RabGAP-TBC PF00566.18 KPI83740.1 - 4.7e-46 157.2 0.0 9e-46 156.2 0.0 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PP2C PF00481.21 KPI83741.1 - 4e-46 157.7 0.4 5.2e-46 157.4 0.4 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KPI83741.1 - 0.002 18.1 0.0 0.014 15.3 0.0 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Pkinase PF00069.25 KPI83742.1 - 8.1e-61 205.7 0.0 4.9e-60 203.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83742.1 - 9.1e-28 97.2 0.0 1.3e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI83742.1 - 3.2e-05 23.4 0.0 6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI83742.1 - 0.0018 17.7 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EMP70 PF02990.16 KPI83743.1 - 1.4e-136 456.2 7.1 1.4e-136 456.2 7.1 1.3 1 1 0 1 1 1 1 Endomembrane protein 70 Kinesin PF00225.23 KPI83744.1 - 3e-89 299.3 0.2 4.1e-89 298.8 0.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI83744.1 - 1.9e-25 89.6 0.0 7.1e-25 87.7 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding TSC22 PF01166.18 KPI83744.1 - 0.0014 18.9 1.4 0.0027 18.0 0.2 2.1 2 0 0 2 2 2 1 TSC-22/dip/bun family YabA PF06156.13 KPI83744.1 - 0.0031 18.1 1.8 0.0061 17.2 0.2 2.4 2 0 0 2 2 2 1 Initiation control protein YabA AAA_16 PF13191.6 KPI83744.1 - 0.004 17.6 0.4 0.03 14.7 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain PIF1 PF05970.14 KPI83744.1 - 0.016 14.4 0.1 0.044 13.0 0.1 1.7 1 0 0 1 1 1 0 PIF1-like helicase AAA_22 PF13401.6 KPI83744.1 - 0.031 14.6 0.1 0.21 11.9 0.0 2.3 2 1 1 3 3 3 0 AAA domain bZIP_1 PF00170.21 KPI83744.1 - 0.033 14.3 0.2 0.033 14.3 0.2 2.3 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.12 KPI83744.1 - 0.31 11.5 4.9 0.56 10.7 0.4 2.7 2 1 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 KPI83744.1 - 1.6 8.5 6.2 1.8 8.4 0.1 3.3 3 0 0 3 3 3 0 Septum formation initiator Ku PF02735.16 KPI83745.1 - 9.1e-30 103.9 0.0 1.5e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 KPI83745.1 - 5.1e-14 52.5 0.0 8e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 KPI83745.1 - 0.67 10.7 5.2 2.6 8.8 0.1 2.8 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm RabGAP-TBC PF00566.18 KPI83746.1 - 4.7e-07 29.7 0.2 7.4e-07 29.0 0.2 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MitMem_reg PF13012.6 KPI83746.1 - 0.005 17.2 0.0 5.7 7.4 0.0 2.6 2 0 0 2 2 2 2 Maintenance of mitochondrial structure and function MTBP_N PF14918.6 KPI83746.1 - 0.15 11.5 0.1 0.28 10.6 0.1 1.3 1 0 0 1 1 1 0 MDM2-binding Rhodanese PF00581.20 KPI83746.1 - 0.15 12.6 0.0 0.39 11.2 0.0 1.7 1 0 0 1 1 1 0 Rhodanese-like domain KASH_CCD PF14662.6 KPI83747.1 - 0.013 15.3 7.0 0.013 15.3 7.0 7.4 2 1 6 8 8 8 0 Coiled-coil region of CCDC155 or KASH BRCA2 PF00634.18 KPI83747.1 - 0.027 14.1 0.5 0.56 9.9 0.1 2.6 2 0 0 2 2 2 0 BRCA2 repeat DUF3113 PF11310.8 KPI83747.1 - 0.05 13.5 0.0 12 6.0 0.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3113) Baculo_PEP_C PF04513.12 KPI83748.1 - 0.043 13.8 6.7 1.1 9.3 0.6 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CREPT PF16566.5 KPI83748.1 - 0.049 13.8 21.5 2.1 8.5 5.4 4.0 3 1 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour FlgN PF05130.12 KPI83748.1 - 0.075 13.5 22.6 0.33 11.5 3.1 3.7 1 1 2 3 3 2 0 FlgN protein ALMT PF11744.8 KPI83748.1 - 0.38 9.5 8.8 0.66 8.7 8.8 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1515 PF07439.11 KPI83748.1 - 0.46 10.5 11.6 17 5.5 0.3 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF1515) AAA_13 PF13166.6 KPI83748.1 - 0.6 8.7 18.1 0.8 8.3 15.4 2.0 2 0 0 2 2 2 0 AAA domain Laminin_II PF06009.12 KPI83748.1 - 1.1 9.2 15.2 0.27 11.2 2.7 3.2 2 1 1 3 3 3 0 Laminin Domain II Fib_alpha PF08702.10 KPI83748.1 - 1.2 9.3 19.6 2.3 8.4 7.9 3.8 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 KPI83748.1 - 1.3 9.6 20.6 8.1 7.0 2.8 3.8 2 1 1 3 3 3 0 Protein of unknown function DUF16 APG17 PF04108.12 KPI83748.1 - 1.3 8.0 22.4 0.37 9.9 0.3 3.1 2 1 1 3 3 3 0 Autophagy protein Apg17 DivIVA PF05103.13 KPI83748.1 - 3.9 7.6 23.9 0.096 12.8 14.3 2.7 2 1 1 3 3 3 0 DivIVA protein DUF1664 PF07889.12 KPI83748.1 - 6.6 6.8 13.9 3 7.9 0.4 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) dCache_2 PF08269.11 KPI83748.1 - 9.5 5.3 9.8 1.3 8.2 0.5 2.4 2 0 0 2 2 2 0 Cache domain Hexapep PF00132.24 KPI83749.1 - 6.9e-07 28.7 12.5 0.16 11.7 0.2 5.2 2 2 3 5 5 5 5 Bacterial transferase hexapeptide (six repeats) NOB1_Zn_bind PF08772.11 KPI83751.1 - 1.9e-24 85.6 0.1 3.4e-24 84.8 0.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 KPI83751.1 - 1.1e-22 80.3 0.2 2e-22 79.5 0.2 1.4 1 0 0 1 1 1 1 PIN domain of ribonuclease DUF35_N PF12172.8 KPI83751.1 - 0.00063 19.6 0.5 0.0014 18.5 0.5 1.5 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 KPI83751.1 - 0.025 14.6 0.2 0.043 13.8 0.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon CENP-B_dimeris PF09026.10 KPI83751.1 - 1.4 9.4 9.9 9.5 6.7 7.2 3.1 3 0 0 3 3 3 0 Centromere protein B dimerisation domain TetR_C_34 PF17929.1 KPI83753.1 - 0.0058 16.7 0.8 0.24 11.5 0.0 2.7 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain DUF2175 PF09943.9 KPI83753.1 - 0.81 10.0 4.1 1.5 9.2 0.4 3.1 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) CK_II_beta PF01214.18 KPI83754.1 - 5.9e-74 247.8 0.0 7.4e-74 247.5 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HscB_4_cys PF18256.1 KPI83754.1 - 1.7 8.5 4.4 7.3 6.5 0.2 2.9 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif HU-CCDC81_euk_2 PF18289.1 KPI83756.1 - 1.1e-16 60.7 0.0 2.1e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 KPI83756.1 - 9.2e-12 45.0 0.0 1.5e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 PPR_2 PF13041.6 KPI83757.1 - 1.6e-07 31.4 0.5 0.017 15.3 0.0 2.3 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 KPI83757.1 - 0.0021 18.1 0.0 0.34 11.0 0.0 2.3 2 0 0 2 2 2 2 Pentatricopeptide repeat domain RPA_C PF08784.11 KPI83758.1 - 1.4e-13 51.4 0.1 1.4e-13 51.4 0.1 2.0 3 0 0 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 KPI83758.1 - 3.4e-08 33.3 0.1 6.3e-08 32.5 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Peroxin-13_N PF04088.13 KPI83759.1 - 3.3 8.0 4.9 3.4 7.9 3.3 1.8 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Rtt102p PF09510.10 KPI83759.1 - 4 7.7 7.9 1.3 9.2 3.6 2.0 2 0 0 2 2 2 0 Rtt102p-like transcription regulator protein TFIIA PF03153.13 KPI83759.1 - 7.4 6.4 16.9 7.2 6.5 15.9 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Thiolase_N PF00108.23 KPI83761.1 - 0.053 12.9 0.1 0.2 11.0 0.0 1.9 1 1 1 2 2 2 0 Thiolase, N-terminal domain tRNA-synt_2 PF00152.20 KPI83762.1 - 6.5e-75 252.1 0.0 8.2e-75 251.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KPI83762.1 - 1.2e-13 50.8 0.0 2.4e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KPI83762.1 - 3.3e-06 26.8 0.0 0.032 13.7 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) ComC PF03047.14 KPI83762.1 - 0.062 13.1 0.0 0.21 11.4 0.0 1.9 1 0 0 1 1 1 0 COMC family WD40 PF00400.32 KPI83763.1 - 6.1e-09 36.4 4.4 0.00078 20.2 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat Staph_haemo PF05480.11 KPI83763.1 - 0.14 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Staphylococcus haemolytic protein Metallophos PF00149.28 KPI83765.1 - 5.6e-30 105.4 0.0 7.5e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI83765.1 - 0.0019 18.6 0.7 0.0074 16.7 0.1 2.1 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain S1-P1_nuclease PF02265.16 KPI83767.1 - 2.2e-13 50.6 0.0 3e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 S1/P1 Nuclease DUF866 PF05907.13 KPI83769.1 - 2.2e-31 108.9 0.5 2.4e-31 108.7 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zf-C4pol PF14260.6 KPI83769.1 - 0.0032 17.9 0.4 0.005 17.3 0.4 1.3 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DUF2173 PF09941.9 KPI83769.1 - 0.042 14.2 0.2 0.085 13.2 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2173) Zn_Tnp_IS1595 PF12760.7 KPI83769.1 - 0.1 12.6 2.4 0.3 11.1 2.4 1.7 1 1 0 1 1 1 0 Transposase zinc-ribbon domain TK PF00265.18 KPI83769.1 - 0.25 11.2 2.3 0.24 11.3 0.8 1.7 2 0 0 2 2 2 0 Thymidine kinase Fe-ADH PF00465.19 KPI83770.1 - 6.9e-117 390.3 3.3 7.8e-117 390.1 3.3 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 KPI83770.1 - 3.5e-15 56.4 3.3 1.1e-06 28.6 0.0 2.1 1 1 1 2 2 2 2 Iron-containing alcohol dehydrogenase Bromodomain PF00439.25 KPI83771.1 - 0.065 13.3 0.0 0.85 9.7 0.0 2.2 1 1 0 1 1 1 0 Bromodomain TFIIA PF03153.13 KPI83771.1 - 1 9.3 8.1 1.5 8.7 8.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Noelin-1 PF12308.8 KPI83773.1 - 0.083 12.9 2.3 0.67 10.0 0.1 3.0 3 0 0 3 3 3 0 Neurogenesis glycoprotein SKA2 PF16740.5 KPI83773.1 - 0.94 9.3 5.8 0.46 10.3 0.2 2.9 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Methyltransf_32 PF13679.6 KPI83773.1 - 4.8 7.2 5.9 17 5.3 0.3 2.5 2 0 0 2 2 2 0 Methyltransferase domain SelR PF01641.18 KPI83775.1 - 6.3e-05 23.0 0.1 0.0089 16.1 0.0 2.4 2 0 0 2 2 2 2 SelR domain Synaptobrevin PF00957.21 KPI83776.1 - 7.7e-26 89.7 0.5 1.2e-25 89.1 0.5 1.3 1 0 0 1 1 1 1 Synaptobrevin zf-RING_2 PF13639.6 KPI83777.1 - 9.9e-09 35.4 3.7 3.6e-07 30.4 1.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 KPI83777.1 - 4.1e-08 33.4 2.3 1.4e-07 31.7 0.7 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KPI83777.1 - 1.1e-06 28.4 3.2 7.1e-06 25.8 0.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI83777.1 - 2.3e-06 27.4 3.2 3.8e-05 23.4 1.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI83777.1 - 0.00019 21.4 5.7 0.0015 18.5 1.1 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KPI83777.1 - 0.00054 19.8 1.5 0.0056 16.5 0.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KPI83777.1 - 0.00056 19.9 0.8 0.00084 19.3 0.2 1.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KPI83777.1 - 0.00076 19.2 8.9 0.01 15.6 0.2 2.5 3 0 0 3 3 2 2 RING-like zinc finger zf-Nse PF11789.8 KPI83777.1 - 0.0011 18.8 0.6 0.0023 17.7 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 KPI83777.1 - 0.0015 18.5 1.8 0.0033 17.4 0.5 2.0 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 KPI83777.1 - 0.004 16.7 1.2 0.004 16.7 1.2 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KPI83777.1 - 0.027 14.3 1.3 0.027 14.3 1.3 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KPI83777.1 - 0.16 12.1 3.4 0.28 11.4 1.3 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 KPI83777.1 - 1.8 8.8 5.9 55 4.0 3.8 3.0 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 KPI83777.1 - 2.4 8.4 6.6 0.41 10.8 1.8 2.0 2 0 0 2 2 2 0 RING-variant domain RF-1 PF00472.20 KPI83779.1 - 9.6e-10 38.4 0.5 9.6e-10 38.4 0.5 3.6 3 1 0 3 3 3 1 RF-1 domain HMG_box_5 PF14887.6 KPI83779.1 - 0.036 14.0 0.3 0.036 14.0 0.3 2.7 2 0 0 2 2 2 0 HMG (high mobility group) box 5 DUF4250 PF14056.6 KPI83779.1 - 0.087 12.8 0.1 0.32 11.0 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF812 PF05667.11 KPI83779.1 - 0.74 8.6 16.6 0.03 13.2 10.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF812) SMC_N PF02463.19 KPI83782.1 - 4.5e-72 242.1 0.0 7.1e-72 241.4 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KPI83782.1 - 8.7e-19 68.0 0.2 3.5e-18 66.0 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KPI83782.1 - 1.9e-11 44.4 1.4 3.8e-05 23.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI83782.1 - 2e-10 41.5 0.1 2e-10 41.5 0.1 6.3 4 2 1 6 6 5 1 AAA domain AAA_15 PF13175.6 KPI83782.1 - 8.8e-08 32.2 0.0 8.8e-08 32.2 0.0 3.7 2 2 0 2 2 1 1 AAA ATPase domain AAA_29 PF13555.6 KPI83782.1 - 2e-05 24.2 0.0 4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain HlyE PF06109.13 KPI83782.1 - 0.0022 17.4 1.8 0.13 11.6 0.1 3.0 1 1 1 2 2 2 1 Haemolysin E (HlyE) CARD PF00619.21 KPI83782.1 - 0.02 14.9 3.9 0.1 12.7 0.0 3.2 3 1 0 3 3 3 0 Caspase recruitment domain ABC_tran PF00005.27 KPI83782.1 - 0.48 10.9 0.0 0.48 10.9 0.0 5.0 5 1 0 5 5 4 0 ABC transporter AAA_22 PF13401.6 KPI83782.1 - 2.9 8.2 0.0 2.9 8.2 0.0 3.5 4 0 0 4 4 4 0 AAA domain Lipoprotein_6 PF01441.19 KPI83782.1 - 9.8 6.2 16.2 0.33 11.0 3.0 3.3 2 1 0 2 2 2 0 Lipoprotein EMP24_GP25L PF01105.24 KPI83783.1 - 5.1e-25 88.5 0.0 6.1e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3395 PF11875.8 KPI83783.1 - 0.16 11.8 0.1 0.23 11.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) EMP24_GP25L PF01105.24 KPI83784.1 - 6.6e-16 58.8 0.0 7.2e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EMP24_GP25L PF01105.24 KPI83785.1 - 1.2e-28 100.2 0.0 1.5e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4498 PF14926.6 KPI83786.1 - 4.4e-17 62.2 0.0 2.6e-08 33.5 0.0 4.0 4 0 0 4 4 4 3 Domain of unknown function (DUF4498) Arrestin_N PF00339.29 KPI83787.1 - 7.5e-12 45.5 0.5 7.4e-05 22.8 0.1 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KPI83787.1 - 2.3e-07 31.3 0.3 1.6e-05 25.4 0.0 2.7 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain FAM184 PF15665.5 KPI83789.1 - 0.003 17.4 6.5 0.005 16.7 6.5 1.2 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B MAD PF05557.13 KPI83789.1 - 0.0044 15.5 4.1 0.0062 15.0 4.1 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Apolipoprotein PF01442.18 KPI83789.1 - 0.0074 16.2 3.6 0.012 15.5 3.6 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DHR10 PF18595.1 KPI83789.1 - 0.014 15.4 5.0 1.2 9.2 1.2 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 KPI83789.1 - 0.039 12.8 3.1 0.061 12.2 3.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 KPI83789.1 - 0.055 14.1 1.3 0.41 11.3 0.1 2.5 1 1 1 2 2 2 0 SlyX AAA_13 PF13166.6 KPI83789.1 - 0.12 11.0 1.3 0.16 10.6 1.3 1.1 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.12 KPI83789.1 - 0.17 12.0 1.9 1.3 9.0 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 KPI83789.1 - 0.17 12.0 0.9 0.34 11.1 0.4 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family HAP1_N PF04849.13 KPI83789.1 - 0.57 9.3 6.7 2.4 7.3 6.9 1.6 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Atg14 PF10186.9 KPI83789.1 - 0.63 9.1 4.3 1 8.4 4.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 KPI83789.1 - 1.2 8.7 4.0 1.9 8.0 4.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPR_MLP1_2 PF07926.12 KPI83789.1 - 1.4 9.0 5.6 5.5 7.1 5.6 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 KPI83789.1 - 7.3 6.8 9.2 5.2e+02 0.7 9.2 2.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) BPL_LplA_LipB PF03099.19 KPI83790.1 - 1.4e-11 44.4 0.0 2.1e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Guanylate_cyc_2 PF09778.9 KPI83790.1 - 0.17 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Guanylylate cyclase SET PF00856.28 KPI83791.1 - 8.2e-05 23.0 0.0 0.0017 18.8 0.0 2.5 1 1 0 1 1 1 1 SET domain Red1 PF07964.11 KPI83792.1 - 2.8 6.1 24.1 3.5 5.8 24.1 1.1 1 0 0 1 1 1 0 Rec10 / Red1 SHIPPO-rpt PF07004.12 KPI83793.1 - 1.1e-06 29.3 40.9 0.037 14.9 0.4 10.0 9 2 0 9 9 9 5 Sperm-tail PG-rich repeat Alpha-amylase_C PF02806.18 KPI83793.1 - 0.013 15.9 0.1 0.049 14.1 0.1 1.9 2 0 0 2 2 2 0 Alpha amylase, C-terminal all-beta domain Arrestin_N PF00339.29 KPI83794.1 - 9.6e-09 35.4 0.5 4.9e-08 33.2 0.0 2.4 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain HAP2-GCS1 PF10699.9 KPI83796.1 - 1.8e-18 66.2 0.0 4e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Male gamete fusion factor Pkinase PF00069.25 KPI83799.1 - 2.7e-53 181.0 0.0 6.9e-34 117.4 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83799.1 - 9.1e-24 84.1 0.1 3.4e-18 65.9 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase EF-hand_6 PF13405.6 KPI83799.1 - 4.2e-08 32.5 0.1 0.0044 16.9 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KPI83799.1 - 5.9e-07 29.8 4.2 0.0024 18.3 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI83799.1 - 8.3e-05 21.9 0.1 0.16 11.6 0.0 3.1 3 0 0 3 3 3 2 EF hand Kinase-like PF14531.6 KPI83799.1 - 0.0002 20.8 0.0 0.066 12.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KPI83799.1 - 0.024 14.0 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_8 PF13833.6 KPI83799.1 - 0.15 11.9 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair LRR_4 PF12799.7 KPI83800.1 - 1.5e-16 60.2 15.3 0.00061 20.1 0.0 7.9 7 1 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83800.1 - 1.9e-16 59.5 18.6 1.4e-05 24.7 0.0 7.1 6 1 0 7 7 7 4 Leucine rich repeat LRR_1 PF00560.33 KPI83800.1 - 0.00033 20.8 12.2 23 6.0 0.0 9.1 9 1 0 9 9 9 2 Leucine Rich Repeat Rdx PF10262.9 KPI83801.1 - 8.9e-06 25.8 0.0 9.4e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Rdx family A1_Propeptide PF07966.12 KPI83801.1 - 0.05 13.5 0.2 0.075 12.9 0.2 1.3 1 0 0 1 1 1 0 A1 Propeptide RskA PF10099.9 KPI83802.1 - 0.0015 18.8 0.0 0.0038 17.6 0.0 1.7 1 1 0 1 1 1 1 Anti-sigma-K factor rskA DUF572 PF04502.13 KPI83802.1 - 0.014 15.0 4.6 0.016 14.9 4.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4179 PF13786.6 KPI83802.1 - 0.1 13.1 0.1 0.47 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Rdx PF10262.9 KPI83803.1 - 0.026 14.7 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 Rdx family HHV-1_VABD PF16852.5 KPI83803.1 - 0.11 12.6 0.3 0.26 11.4 0.3 1.5 1 0 0 1 1 1 0 Herpes viral adaptor-to-host cellular mRNA binding domain SPG4 PF17325.2 KPI83803.1 - 0.13 13.3 0.3 0.39 11.8 0.3 1.8 1 0 0 1 1 1 0 Stationary phase protein 4 Kri1 PF05178.12 KPI83805.1 - 2.3e-20 73.1 8.0 2.3e-20 73.1 8.0 4.2 5 1 0 5 5 5 1 KRI1-like family Kri1_C PF12936.7 KPI83805.1 - 6.8e-19 67.8 0.1 6.8e-19 67.8 0.1 2.5 2 0 0 2 2 2 1 KRI1-like family C-terminal RRM_1 PF00076.22 KPI83807.1 - 0.16 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 KPI83808.1 - 2.3e-63 214.0 0.0 6.1e-63 212.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83808.1 - 1.1e-22 80.5 0.0 4.2e-22 78.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI83808.1 - 3.5e-05 23.3 0.1 0.0058 16.0 0.1 2.4 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KPI83808.1 - 0.00042 19.7 0.0 0.0008 18.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI83808.1 - 0.012 14.4 1.0 0.063 12.1 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 KPI83808.1 - 0.015 15.0 0.4 0.31 10.6 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 KPI83808.1 - 0.16 11.5 0.5 2.4 7.6 0.1 2.7 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Macoilin PF09726.9 KPI83808.1 - 0.17 10.4 4.7 0.23 10.0 4.7 1.1 1 0 0 1 1 1 0 Macoilin family TipAS PF07739.13 KPI83808.1 - 0.39 11.3 1.4 1.1 9.9 0.5 2.2 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain zf-CRD PF17979.1 KPI83809.1 - 2e-43 148.2 0.7 2e-43 148.2 0.7 3.0 2 1 1 3 3 2 1 Cysteine rich domain with multizinc binding regions FHA PF00498.26 KPI83809.1 - 5.3e-12 45.9 0.1 1.1e-11 44.9 0.1 1.6 1 0 0 1 1 1 1 FHA domain zf-C3HC4 PF00097.25 KPI83809.1 - 8e-08 32.0 12.1 8e-08 32.0 12.1 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI83809.1 - 3.1e-07 30.3 8.3 3.1e-07 30.3 8.3 3.0 3 1 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KPI83809.1 - 5.5e-07 29.3 13.4 5.5e-07 29.3 13.4 3.4 5 0 0 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-CCHH PF10283.9 KPI83809.1 - 1.1e-06 28.5 8.4 2.4e-06 27.4 8.4 1.6 1 0 0 1 1 1 1 PBZ domain zf-RING_2 PF13639.6 KPI83809.1 - 2.2e-06 27.9 14.7 2.2e-06 27.9 14.7 3.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 KPI83809.1 - 0.00012 22.2 12.1 0.00012 22.2 12.1 3.6 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING FHA_2 PF17913.1 KPI83809.1 - 0.00029 21.0 0.0 0.00056 20.1 0.0 1.4 1 0 0 1 1 1 1 FHA domain zf-RING_5 PF14634.6 KPI83809.1 - 0.00045 20.1 12.7 0.00045 20.1 12.7 3.6 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 KPI83809.1 - 0.0031 17.4 7.0 0.0031 17.4 7.0 2.4 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 KPI83809.1 - 0.011 15.5 4.8 0.034 14.0 4.8 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 KPI83809.1 - 8.6 6.7 25.3 0.14 12.4 13.4 3.4 2 1 0 2 2 1 0 RING-H2 zinc finger domain Kinesin PF00225.23 KPI83810.1 - 1.5e-80 270.7 0.0 1.6e-47 162.1 0.0 2.6 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI83810.1 - 1.8e-16 60.4 0.0 3.1e-15 56.4 0.0 2.9 2 1 0 2 2 2 1 Microtubule binding Cep57_CLD_2 PF14197.6 KPI83810.1 - 0.003 17.6 7.3 0.003 17.6 7.3 5.6 5 1 1 6 6 6 1 Centrosome localisation domain of PPC89 UPF0561 PF10573.9 KPI83810.1 - 0.22 11.7 2.6 0.89 9.7 2.6 2.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 AAA_22 PF13401.6 KPI83810.1 - 0.25 11.6 0.0 0.25 11.6 0.0 3.5 4 1 0 4 4 4 0 AAA domain DUF87 PF01935.17 KPI83810.1 - 0.37 10.9 0.0 0.37 10.9 0.0 3.3 4 0 0 4 4 4 0 Helicase HerA, central domain SUIM_assoc PF16619.5 KPI83811.1 - 0.37 10.9 5.7 0.52 10.4 0.8 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 CitT PF12431.8 KPI83811.1 - 0.41 11.1 1.4 3.3 8.2 1.4 2.6 1 0 0 1 1 1 0 Transcriptional regulator BILBO1_N PF18281.1 KPI83813.1 - 7.6e-32 109.6 0.1 2.5e-31 108.0 0.1 2.0 1 0 0 1 1 1 1 BILBO1 N-terminal domain EF-hand_7 PF13499.6 KPI83813.1 - 1.1e-09 38.5 3.3 1.1e-09 38.5 3.3 3.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI83813.1 - 4.3e-07 29.0 3.5 0.0026 17.2 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KPI83813.1 - 1.9e-05 24.2 2.4 0.34 11.0 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KPI83813.1 - 0.0014 18.4 3.2 0.053 13.4 0.5 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KPI83813.1 - 0.0032 16.9 0.1 0.0092 15.4 0.0 1.9 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 KPI83813.1 - 0.59 10.5 0.0 0.59 10.5 0.0 3.1 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region RRM_1 PF00076.22 KPI83814.1 - 3.4e-15 55.6 0.0 4.9e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KPI83815.1 - 9.8e-36 121.4 0.0 1.4e-17 63.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 KPI83815.1 - 0.0001 22.1 0.0 0.17 11.7 0.0 2.3 2 0 0 2 2 2 2 Rrp7 RRM-like N-terminal domain Limkain-b1 PF11608.8 KPI83815.1 - 0.0016 18.5 0.1 1.5 8.9 0.0 3.3 3 0 0 3 3 3 1 Limkain b1 RRM_7 PF16367.5 KPI83815.1 - 0.0028 17.7 0.0 0.15 12.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 KPI83815.1 - 0.092 12.3 0.0 6.5 6.4 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATG_C PF09333.11 KPI83818.1 - 0.015 15.6 0.1 0.66 10.4 0.1 3.0 1 1 0 1 1 1 0 Autophagy-related protein C terminal domain ATP-grasp_4 PF13535.6 KPI83819.1 - 7.7e-07 28.8 0.0 0.00017 21.2 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain LAL_C2 PF18603.1 KPI83819.1 - 9.1e-06 25.7 0.2 7.4e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 L-amino acid ligase C-terminal domain 2 ATP-grasp_3 PF02655.14 KPI83819.1 - 0.00062 19.9 0.0 0.0089 16.1 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_N PF18130.1 KPI83819.1 - 0.0027 18.2 0.0 0.0065 17.0 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATPgrasp_Ter PF15632.6 KPI83819.1 - 0.02 14.7 0.1 2.9 7.6 0.1 2.4 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D2 PF02786.17 KPI83819.1 - 0.063 12.8 0.0 0.67 9.4 0.0 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain GCS PF03074.16 KPI83822.1 - 1.3e-137 459.0 0.0 2.1e-137 458.4 0.0 1.3 1 0 0 1 1 1 1 Glutamate-cysteine ligase DnaJ PF00226.31 KPI83823.1 - 2.6e-12 46.7 0.0 1.3e-11 44.5 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain TPR_2 PF07719.17 KPI83823.1 - 5.5e-12 44.8 12.1 0.032 14.3 0.0 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83823.1 - 2.6e-09 37.2 20.7 0.00035 20.8 3.2 4.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI83823.1 - 3.3e-07 30.7 7.5 1.1 9.8 0.7 5.3 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83823.1 - 9.7e-06 25.2 9.0 0.018 14.9 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83823.1 - 0.00063 19.9 14.1 0.023 14.9 0.1 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KPI83823.1 - 0.17 12.6 16.7 5.1 8.0 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI83823.1 - 0.18 11.9 14.9 5.5 7.2 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI83823.1 - 0.33 11.1 3.2 30 4.8 0.2 3.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 KPI83823.1 - 0.36 11.8 23.4 6.2 7.9 0.5 6.4 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83823.1 - 0.52 11.0 22.4 0.035 14.8 5.5 4.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI83823.1 - 3.7 7.5 8.1 12 5.9 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TetR_C_11 PF16859.5 KPI83825.1 - 9.6 6.6 13.2 0.71 10.2 0.7 3.0 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MatE PF01554.18 KPI83826.1 - 4.6e-43 146.7 22.8 2.3e-29 102.1 9.0 2.4 2 0 0 2 2 2 2 MatE GlnE PF03710.15 KPI83827.1 - 0.063 12.7 0.1 0.09 12.2 0.1 1.2 1 0 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase Got1 PF04178.12 KPI83828.1 - 1.4e-12 48.1 13.8 1.7e-12 47.7 13.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Noc2 PF03715.13 KPI83829.1 - 6.5e-88 294.8 1.8 6.5e-88 294.8 1.8 1.5 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 KPI83829.1 - 0.01 14.1 26.7 0.087 11.0 0.1 2.6 3 0 0 3 3 3 0 Nop14-like family YdjC PF04794.12 KPI83829.1 - 0.037 14.0 1.5 0.19 11.7 0.1 2.4 2 0 0 2 2 2 0 YdjC-like protein PTPA PF03095.15 KPI83829.1 - 0.098 12.1 1.3 10 5.5 0.1 2.5 2 0 0 2 2 2 0 Phosphotyrosyl phosphate activator (PTPA) protein DUF5401 PF17380.2 KPI83829.1 - 0.26 9.3 8.4 0.38 8.8 8.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Isy1 PF06246.12 KPI83829.1 - 0.71 9.4 9.3 1.6 8.3 9.3 1.6 1 0 0 1 1 1 0 Isy1-like splicing family Kinesin PF00225.23 KPI83830.1 - 7.3e-62 209.2 0.1 1.5e-61 208.2 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI83830.1 - 1.8e-08 34.5 0.0 3.4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Caldesmon PF02029.15 KPI83830.1 - 0.17 10.6 0.9 0.3 9.8 0.9 1.3 1 0 0 1 1 1 0 Caldesmon Ribosomal_L1 PF00687.21 KPI83832.1 - 4.3e-10 39.7 0.0 0.0007 19.4 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein L1p/L10e family PIF1 PF05970.14 KPI83833.1 - 5.9e-10 38.8 0.0 8e-06 25.3 0.0 2.8 1 1 1 2 2 2 2 PIF1-like helicase UvrD_C_2 PF13538.6 KPI83833.1 - 0.00017 21.4 0.2 0.00036 20.3 0.2 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 KPI83833.1 - 0.024 12.6 0.0 0.035 12.1 0.0 1.1 1 0 0 1 1 1 0 Helicase Viral_helicase1 PF01443.18 KPI83833.1 - 0.028 14.2 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CRF-BP PF05428.11 KPI83834.1 - 0.1 11.4 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Corticotropin-releasing factor binding protein (CRF-BP) NAD_binding_1 PF00175.21 KPI83835.1 - 8.1e-12 45.8 0.0 1.7e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KPI83835.1 - 4.7e-10 39.7 0.0 8.5e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.22 KPI83835.1 - 1.8e-08 34.9 0.1 6.8e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Globin NAD_binding_6 PF08030.12 KPI83835.1 - 0.0074 16.4 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF4716 PF15837.5 KPI83836.1 - 0.83 9.8 6.2 0.83 9.8 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4716) ATG16 PF08614.11 KPI83836.1 - 2.3 8.4 11.0 1.8 8.8 9.8 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) TK PF00265.18 KPI83837.1 - 2.5e-60 203.3 0.8 3.3e-60 203.0 0.8 1.1 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.6 KPI83837.1 - 0.0035 17.4 0.1 0.0091 16.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain Cytochrome_C7 PF14522.6 KPI83837.1 - 0.26 11.3 2.3 0.58 10.2 2.3 1.6 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c Pox_A_type_inc PF04508.12 KPI83838.1 - 1.1 9.2 7.3 0.1 12.5 0.4 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat WD40 PF00400.32 KPI83839.1 - 1.6e-11 44.5 11.3 2.7e-07 31.2 0.3 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI83839.1 - 0.0055 17.0 0.2 11 6.5 0.0 3.8 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Prefoldin PF02996.17 KPI83839.1 - 0.021 14.7 1.1 0.021 14.7 1.1 2.4 2 0 0 2 2 2 0 Prefoldin subunit BBS2_Mid PF14783.6 KPI83839.1 - 0.041 13.9 0.0 4 7.5 0.0 3.1 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region FAM76 PF16046.5 KPI83839.1 - 0.053 12.9 2.1 0.086 12.2 2.1 1.2 1 0 0 1 1 1 0 FAM76 protein YqjK PF13997.6 KPI83839.1 - 0.14 12.5 5.0 0.59 10.4 2.5 2.6 2 0 0 2 2 2 0 YqjK-like protein Corona_nucleoca PF00937.18 KPI83839.1 - 0.53 9.3 7.7 0.031 13.3 1.9 1.7 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein PQQ_3 PF13570.6 KPI83839.1 - 0.57 10.7 4.6 5.7 7.6 0.1 4.1 5 0 0 5 5 5 0 PQQ-like domain PRKG1_interact PF15898.5 KPI83839.1 - 0.78 10.7 7.8 0.86 10.5 5.5 2.2 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 KPI83839.1 - 2.5 7.9 14.8 0.63 9.9 5.5 3.1 3 0 0 3 3 3 0 Septum formation initiator WD40 PF00400.32 KPI83840.1 - 4e-09 37.0 8.7 0.00031 21.5 0.1 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ELYS-bb PF16687.5 KPI83840.1 - 0.02 13.5 0.0 1.2 7.6 0.0 2.1 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin PQQ_3 PF13570.6 KPI83840.1 - 0.16 12.5 5.9 0.29 11.7 0.1 3.9 4 0 0 4 4 4 0 PQQ-like domain Shugoshin_N PF07558.11 KPI83840.1 - 2.6 8.0 10.6 0.26 11.2 2.1 3.3 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region BORCS8 PF10167.9 KPI83840.1 - 3 7.8 5.7 0.98 9.4 0.1 3.0 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 8 UPF0242 PF06785.11 KPI83840.1 - 5.4 7.1 63.6 0.011 15.9 9.4 5.6 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_M3 PF01432.20 KPI83841.1 - 1.8e-118 396.7 0.3 5e-118 395.3 0.0 1.8 2 1 0 2 2 2 1 Peptidase family M3 Peptidase_M50B PF13398.6 KPI83841.1 - 0.072 12.7 0.3 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Peptidase M50B-like DUF108 PF01958.18 KPI83842.1 - 0.09 13.1 0.1 0.33 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF108 WD40 PF00400.32 KPI83843.1 - 2.2e-09 37.8 4.2 0.22 12.4 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat EF-hand_1 PF00036.32 KPI83843.1 - 1.2e-08 33.9 0.3 0.0024 17.3 0.5 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KPI83843.1 - 2.6e-07 30.0 0.9 0.012 15.4 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KPI83843.1 - 3.5e-07 30.6 0.2 1.1e-06 29.0 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KPI83843.1 - 6.8e-05 22.6 1.8 0.047 13.5 0.7 2.6 1 1 1 2 2 2 2 EF-hand domain pair Gelsolin PF00626.22 KPI83843.1 - 0.0027 17.6 0.6 0.0069 16.3 0.6 1.6 1 0 0 1 1 1 1 Gelsolin repeat ANAPC4_WD40 PF12894.7 KPI83843.1 - 0.0031 17.8 0.1 4.8 7.6 0.0 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_5 PF13202.6 KPI83843.1 - 0.0033 16.8 0.7 1.2 8.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 KPI83843.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand PQQ_3 PF13570.6 KPI83843.1 - 0.19 12.3 0.2 13 6.5 0.1 3.6 4 0 0 4 4 4 0 PQQ-like domain U-box PF04564.15 KPI83844.1 - 0.00019 21.5 0.1 0.00084 19.5 0.0 2.2 3 0 0 3 3 3 1 U-box domain HAUS6_N PF14661.6 KPI83844.1 - 1.8 8.1 4.9 23 4.5 4.9 2.2 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Pro_dh PF01619.18 KPI83845.1 - 1.4e-66 225.0 0.5 2.4e-66 224.3 0.3 1.5 2 0 0 2 2 2 1 Proline dehydrogenase EF-hand_7 PF13499.6 KPI83845.1 - 0.033 14.7 0.1 0.092 13.2 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KPI83845.1 - 0.063 12.8 0.1 0.25 11.0 0.1 2.1 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 KPI83845.1 - 0.16 11.9 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair CTP_transf_1 PF01148.20 KPI83846.1 - 3.8e-62 210.4 20.4 5.2e-62 210.0 20.4 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Ribosomal_S28e PF01200.18 KPI83847.1 - 1.5e-29 101.7 0.7 2.2e-29 101.2 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein S28e SIS_2 PF13580.6 KPI83847.1 - 0.049 13.6 0.1 0.094 12.7 0.1 1.5 1 1 0 1 1 1 0 SIS domain MIT PF04212.18 KPI83848.1 - 8.7e-07 28.9 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 KPI83848.1 - 0.061 13.0 0.7 12 5.7 0.1 2.4 2 0 0 2 2 2 0 TPR repeat Spo0A_C PF08769.11 KPI83848.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal TPR_8 PF13181.6 KPI83848.1 - 0.14 12.4 0.1 1.3 9.5 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat LRR_1 PF00560.33 KPI83849.1 - 2.6e-05 24.1 6.4 1.5 9.6 0.0 7.0 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 KPI83849.1 - 0.00025 20.8 12.4 2.3 8.5 0.0 7.7 9 0 0 9 9 9 2 Leucine Rich repeat LRR_4 PF12799.7 KPI83849.1 - 0.038 14.4 8.9 0.86 10.1 0.4 5.0 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83849.1 - 0.12 12.2 6.7 0.8 9.5 0.0 4.8 5 1 0 5 5 5 0 Leucine rich repeat MMS1_N PF10433.9 KPI83851.1 - 2.9e-29 102.1 0.0 4.4e-18 65.2 0.0 3.6 3 1 0 3 3 3 3 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KPI83851.1 - 3.4e-15 56.2 0.0 9.8e-12 44.8 0.0 2.8 2 1 0 2 2 2 2 CPSF A subunit region DUF4228 PF14009.6 KPI83851.1 - 8.9 6.7 9.2 3 8.2 0.1 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4228) zf-C2HC_2 PF13913.6 KPI83855.1 - 6.8e-17 60.9 8.4 3.3e-09 36.4 1.4 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 KPI83855.1 - 0.047 14.5 0.9 4.7 8.3 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-CpG_bind_C PF12269.8 KPI83855.1 - 0.061 13.1 0.2 4.3 7.0 0.0 2.4 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain ADK_lid PF05191.14 KPI83855.1 - 0.13 12.2 4.0 4.9 7.2 0.1 3.3 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf_UBZ PF18439.1 KPI83855.1 - 0.19 11.4 0.6 10 5.8 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KPI83855.1 - 0.25 11.5 2.4 17 5.6 0.2 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2 PF00096.26 KPI83855.1 - 0.34 11.5 3.0 22 5.8 0.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF2256 PF10013.9 KPI83855.1 - 0.91 9.7 2.4 21 5.3 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-FPG_IleRS PF06827.14 KPI83855.1 - 2.2 8.2 5.8 5.1 7.1 0.2 2.6 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zinc_ribbon_9 PF14369.6 KPI83855.1 - 3.3 8.1 4.8 1.2 9.4 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbon IBP39 PF11422.8 KPI83857.1 - 0.44 10.3 4.7 0.88 9.3 4.7 1.5 1 0 0 1 1 1 0 Initiator binding protein 39 kDa Pkinase PF00069.25 KPI83858.1 - 4.4e-25 88.5 0.1 6.1e-25 88.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83858.1 - 3.9e-16 59.1 0.0 4.4e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI83858.1 - 1e-06 27.9 0.2 1.2e-06 27.5 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KPI83858.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI83858.1 - 0.023 14.3 0.2 3 7.4 0.0 2.3 2 0 0 2 2 2 0 RIO1 family LRR_6 PF13516.6 KPI83860.1 - 7.7e-06 25.6 0.0 2.8 8.2 0.0 3.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_8 PF13855.6 KPI83860.1 - 0.0031 17.3 0.6 1 9.2 0.2 3.0 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI83860.1 - 0.0059 17.0 0.3 0.096 13.1 0.1 2.8 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI83860.1 - 0.077 13.6 0.9 22 6.1 0.0 3.8 5 0 0 5 5 5 0 Leucine Rich Repeat PolyA_pol PF01743.20 KPI83861.1 - 2.7e-28 98.9 0.0 5.2e-28 98.0 0.0 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 KPI83861.1 - 3.3e-06 26.8 0.0 6.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A UPF0126 PF03458.13 KPI83861.1 - 0.059 13.3 0.6 8.9 6.3 0.1 2.4 2 0 0 2 2 2 0 UPF0126 domain RRM_1 PF00076.22 KPI83863.1 - 6.2e-14 51.6 0.0 1.3e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI83863.1 - 1.5e-08 34.3 0.1 0.00062 19.4 0.1 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KPI83863.1 - 0.00011 22.0 0.2 0.0013 18.6 0.1 2.3 2 1 0 2 2 2 1 Occluded RNA-recognition motif CDC48_2 PF02933.17 KPI83863.1 - 0.00037 20.2 0.0 0.00088 19.0 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 RRM_8 PF11835.8 KPI83863.1 - 0.0091 16.2 0.2 0.023 14.9 0.2 1.8 1 0 0 1 1 1 1 RRM-like domain MOEP19 PF16005.5 KPI83863.1 - 0.11 12.5 0.3 0.43 10.6 0.1 2.0 2 0 0 2 2 2 0 KH-like RNA-binding domain ComGF PF15980.5 KPI83863.1 - 0.15 12.4 2.2 0.12 12.7 0.6 1.7 2 0 0 2 2 2 0 Putative Competence protein ComGF Abhydrolase_1 PF00561.20 KPI83864.1 - 1.8e-19 70.4 0.1 3e-09 36.9 0.4 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI83864.1 - 2.1e-14 53.4 0.2 4.2e-14 52.4 0.2 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI83864.1 - 3.9e-08 34.2 1.4 5.2e-08 33.7 1.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KPI83864.1 - 4.1e-05 23.2 0.0 0.014 14.9 0.0 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family Esterase_phd PF10503.9 KPI83864.1 - 0.0053 16.3 0.2 0.38 10.2 0.0 2.1 2 0 0 2 2 2 1 Esterase PHB depolymerase DLH PF01738.18 KPI83864.1 - 0.014 15.0 0.0 0.046 13.3 0.0 1.8 3 0 0 3 3 3 0 Dienelactone hydrolase family Ndr PF03096.14 KPI83864.1 - 0.015 14.0 0.0 0.021 13.6 0.0 1.3 1 0 0 1 1 1 0 Ndr family Abhydrolase_4 PF08386.10 KPI83864.1 - 0.017 15.3 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein FSH1 PF03959.13 KPI83864.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 KPI83864.1 - 0.09 12.6 0.0 0.49 10.2 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase COX14 PF14880.6 KPI83865.1 - 5.6 6.9 7.0 0.24 11.3 0.6 1.9 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF2046 PF09755.9 KPI83866.1 - 0.068 12.4 1.3 0.12 11.5 0.3 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) DUF2368 PF10166.9 KPI83866.1 - 9.6 5.8 6.7 0.57 9.8 1.0 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) SlyX PF04102.12 KPI83868.1 - 0.049 14.3 0.1 0.049 14.3 0.1 3.1 4 0 0 4 4 4 0 SlyX DEAD PF00270.29 KPI83869.1 - 5.8e-43 146.7 0.0 1.8e-42 145.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI83869.1 - 2.1e-32 111.7 0.1 1.3e-31 109.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 KPI83869.1 - 0.0038 16.6 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 KPI83869.1 - 0.0058 16.6 0.0 0.03 14.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KPI83869.1 - 0.027 13.7 0.1 0.039 13.2 0.1 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Vac_Fusion PF02346.16 KPI83870.1 - 1.1 9.0 5.4 12 5.6 0.1 3.6 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF423 PF04241.15 KPI83872.1 - 8.2e-20 70.8 1.7 1.2e-19 70.3 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) DUF423 PF04241.15 KPI83873.1 - 6.1e-15 55.2 1.0 9.4e-15 54.6 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) ATP1G1_PLM_MAT8 PF02038.16 KPI83873.1 - 0.15 11.5 0.2 0.42 10.1 0.2 1.7 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family LBP_BPI_CETP_C PF02886.17 KPI83873.1 - 0.2 11.1 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 LBP / BPI / CETP family, C-terminal domain DUF423 PF04241.15 KPI83874.1 - 1.4e-15 57.2 2.9 2.2e-15 56.6 2.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF423) 2-Hacid_dh_C PF02826.19 KPI83875.1 - 1.2e-46 158.3 0.0 1.5e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 KPI83875.1 - 2.8e-08 34.0 0.4 6e-08 32.9 0.4 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 KPI83875.1 - 2.3e-05 24.6 0.4 3.6e-05 24.0 0.4 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 KPI83875.1 - 3.5e-05 23.2 0.5 5.6e-05 22.5 0.5 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 KPI83875.1 - 0.00016 21.3 0.1 0.00028 20.5 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 KPI83875.1 - 0.0002 21.2 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pyr_redox PF00070.27 KPI83875.1 - 0.0067 17.0 1.0 0.034 14.7 1.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh PF00389.30 KPI83875.1 - 0.0099 15.5 0.0 0.035 13.8 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 KPI83875.1 - 0.01 15.9 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KPI83875.1 - 0.011 16.1 0.1 0.019 15.4 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 KPI83875.1 - 0.019 14.2 0.3 0.035 13.3 0.3 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 KPI83875.1 - 0.1 13.2 0.1 0.84 10.3 0.1 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 KPI83875.1 - 0.27 11.5 0.9 1.8 8.8 0.9 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1143 PF06608.11 KPI83876.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) PTEN_C2 PF10409.9 KPI83877.1 - 9.7e-12 44.8 0.0 1.8e-11 43.9 0.0 1.6 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 KPI83877.1 - 1.6e-06 28.0 0.8 3.4e-06 26.9 0.8 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI83877.1 - 0.00039 20.1 0.1 0.00083 19.0 0.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KPI83877.1 - 0.0006 19.8 0.1 0.0014 18.6 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPn PF14671.6 KPI83877.1 - 0.0046 17.4 0.1 0.014 15.8 0.1 1.8 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 KPI83877.1 - 0.045 13.9 0.1 0.099 12.8 0.1 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 KPI83877.1 - 0.076 12.7 0.7 0.15 11.7 0.7 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) C2 PF00168.30 KPI83878.1 - 0.15 12.4 0.0 29 5.0 0.0 3.5 3 1 0 3 3 3 0 C2 domain KAAG1 PF15354.6 KPI83878.1 - 4.6 7.9 12.6 0.17 12.4 1.3 3.6 3 0 0 3 3 3 0 Kidney-associated antigen 1 R3H-assoc PF13902.6 KPI83879.1 - 8.9e-15 55.3 0.1 2.5e-14 53.8 0.1 1.8 1 0 0 1 1 1 1 R3H-associated N-terminal domain PPR_2 PF13041.6 KPI83880.1 - 0.034 14.3 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 PPR repeat family EAP30 PF04157.16 KPI83881.1 - 1.5e-62 210.9 0.3 2.1e-62 210.5 0.3 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family DUF1664 PF07889.12 KPI83884.1 - 5.3e-06 26.5 13.6 0.0058 16.7 1.7 3.5 1 1 1 3 3 3 2 Protein of unknown function (DUF1664) Spc7 PF08317.11 KPI83884.1 - 0.00014 20.9 16.9 0.019 13.9 2.5 2.2 1 1 1 2 2 2 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KPI83884.1 - 0.0026 17.8 0.4 0.0026 17.8 0.4 3.5 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 KPI83884.1 - 0.0065 16.5 13.5 0.65 10.0 0.7 3.6 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 PF06818.15 KPI83884.1 - 0.0069 16.9 17.9 0.43 11.0 8.0 2.5 1 1 1 2 2 2 2 Fez1 ThiD2 PF17792.1 KPI83884.1 - 0.007 16.8 12.0 0.08 13.4 7.7 2.4 1 1 1 2 2 2 1 ThiD2 family ApoLp-III PF07464.11 KPI83884.1 - 0.014 15.5 5.0 0.052 13.6 0.5 3.1 2 2 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) HK_sensor PF16750.5 KPI83884.1 - 0.022 15.1 3.4 0.022 15.0 1.2 2.2 2 0 0 2 2 2 0 Sensor domain of 2-component histidine kinase IFT57 PF10498.9 KPI83884.1 - 0.025 13.6 9.9 0.024 13.6 2.1 2.2 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 AKNA PF12443.8 KPI83884.1 - 0.04 14.6 2.4 0.17 12.5 0.0 2.8 2 1 0 3 3 2 0 AT-hook-containing transcription factor Snapin_Pallidin PF14712.6 KPI83884.1 - 0.045 14.2 1.5 0.045 14.2 1.5 3.4 2 1 0 3 3 3 0 Snapin/Pallidin Tropomyosin_1 PF12718.7 KPI83884.1 - 0.052 13.7 16.8 0.17 12.0 3.9 2.8 1 1 1 2 2 2 0 Tropomyosin like Vac_Fusion PF02346.16 KPI83884.1 - 0.068 12.8 3.9 2.7 7.7 0.1 3.9 3 2 1 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 LOH1CR12 PF10158.9 KPI83884.1 - 0.069 13.2 2.6 0.62 10.1 0.3 2.4 1 1 0 2 2 2 0 Tumour suppressor protein AAA_13 PF13166.6 KPI83884.1 - 0.08 11.6 9.8 0.26 9.9 9.8 1.7 1 1 0 1 1 1 0 AAA domain DUF948 PF06103.11 KPI83884.1 - 0.083 13.2 8.9 5.8 7.3 1.1 4.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.15 KPI83884.1 - 0.09 12.3 13.9 0.28 10.7 5.4 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit Laminin_II PF06009.12 KPI83884.1 - 0.12 12.4 14.9 0.79 9.7 0.2 3.9 1 1 3 4 4 4 0 Laminin Domain II AAA_23 PF13476.6 KPI83884.1 - 0.15 12.6 1.4 9 6.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 KPI83884.1 - 0.18 12.0 8.7 19 5.4 0.6 3.4 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DivIVA PF05103.13 KPI83884.1 - 0.18 11.9 0.2 0.18 11.9 0.2 3.2 2 1 1 3 3 3 0 DivIVA protein GAS PF13851.6 KPI83884.1 - 0.22 10.8 13.6 0.64 9.3 4.5 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding APG17 PF04108.12 KPI83884.1 - 0.35 9.9 13.6 0.48 9.5 6.1 2.3 1 1 1 2 2 2 0 Autophagy protein Apg17 Prominin PF05478.11 KPI83884.1 - 0.67 7.8 5.4 2 6.2 5.3 1.7 1 1 0 1 1 1 0 Prominin BshC PF10079.9 KPI83884.1 - 0.73 8.5 4.2 0.45 9.2 1.0 1.9 2 0 0 2 2 2 0 Bacillithiol biosynthesis BshC DUF745 PF05335.13 KPI83884.1 - 0.8 9.4 14.3 0.036 13.8 1.1 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF745) CdvA PF18822.1 KPI83884.1 - 0.81 9.5 12.8 0.34 10.7 0.9 3.9 2 2 0 3 3 3 0 CdvA-like coiled-coil domain COG2 PF06148.11 KPI83884.1 - 0.85 9.7 15.3 10 6.2 3.9 4.0 1 1 4 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin_2 PF14523.6 KPI83884.1 - 1.1 9.7 12.2 93 3.5 3.7 3.8 1 1 1 2 2 2 0 Syntaxin-like protein YojJ PF10372.9 KPI83884.1 - 1.1 9.4 6.7 12 6.1 0.2 4.2 3 2 1 5 5 4 0 Bacterial membrane-spanning protein N-terminus ALIX_LYPXL_bnd PF13949.6 KPI83884.1 - 1.6 8.0 21.2 0.03 13.6 3.2 3.4 1 1 1 3 3 3 0 ALIX V-shaped domain binding to HIV Golgin_A5 PF09787.9 KPI83884.1 - 1.6 8.1 18.2 1.5 8.2 7.7 2.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 CREPT PF16566.5 KPI83884.1 - 1.7 8.8 13.1 3 8.0 0.8 3.1 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Prefoldin_2 PF01920.20 KPI83884.1 - 1.9 8.5 10.2 7.1 6.6 1.0 3.6 2 2 0 3 3 3 0 Prefoldin subunit AAA_27 PF13514.6 KPI83884.1 - 2 8.0 10.3 1.5 8.4 0.4 3.0 1 1 1 3 3 3 0 AAA domain DUF2730 PF10805.8 KPI83884.1 - 2.3 8.3 6.2 3.6 7.8 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) YabA PF06156.13 KPI83884.1 - 2.4 8.8 7.7 5.6 7.7 0.2 3.0 2 1 0 2 2 2 0 Initiation control protein YabA Fibin PF15819.5 KPI83884.1 - 2.8 7.7 9.6 0.8 9.4 3.9 2.4 1 1 1 2 2 2 0 Fin bud initiation factor homologue DUF501 PF04417.12 KPI83884.1 - 3.3 7.5 5.3 1.4 8.8 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF501) DUF4795 PF16043.5 KPI83884.1 - 4.1 6.9 15.0 1.7e+02 1.7 15.0 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) RmuC PF02646.16 KPI83884.1 - 4.5 6.3 15.9 2.7 7.0 0.4 3.5 1 1 0 3 3 3 0 RmuC family DUF3347 PF11827.8 KPI83884.1 - 4.6 7.4 5.9 10 6.2 0.3 2.7 1 1 1 3 3 3 0 Protein of unknown function (DUF3347) SIMPL PF04402.14 KPI83884.1 - 5 7.5 12.9 20 5.6 12.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF541) DUF1043 PF06295.12 KPI83884.1 - 6.3 6.8 9.9 2.5 8.1 2.1 3.2 1 1 0 3 3 3 0 Protein of unknown function (DUF1043) Methyltransf_12 PF08242.12 KPI83885.1 - 2.4e-11 44.3 0.0 4.4e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI83885.1 - 1.2e-10 41.9 0.0 2.5e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI83885.1 - 2.8e-09 37.5 0.0 5.3e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI83885.1 - 5.9e-05 23.0 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI83885.1 - 0.00042 19.7 0.0 0.0007 19.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KPI83885.1 - 0.00058 19.7 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KPI83885.1 - 0.0011 18.8 0.1 0.0022 17.9 0.1 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Ank_2 PF12796.7 KPI83886.1 - 7.4e-15 55.3 1.2 5.9e-08 33.2 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI83886.1 - 3.7e-12 45.3 0.7 0.21 12.3 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KPI83886.1 - 4.9e-11 42.7 1.2 5e-08 33.1 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KPI83886.1 - 2.4e-09 37.6 0.2 0.015 15.8 0.0 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KPI83886.1 - 3e-07 30.6 11.7 0.33 11.5 0.0 5.9 6 1 0 6 6 6 3 Ankyrin repeat EAP30 PF04157.16 KPI83887.1 - 6.3e-22 78.0 0.1 9.1e-22 77.5 0.1 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 KPI83887.1 - 1.6e-21 76.3 0.0 2.8e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Ribosomal_S25 PF03297.15 KPI83887.1 - 0.061 13.5 0.0 0.7 10.1 0.0 2.4 2 0 0 2 2 2 0 S25 ribosomal protein Ribosomal_60s PF00428.19 KPI83887.1 - 4.9 7.8 6.3 0.71 10.5 1.5 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Herpes_UL51 PF04540.13 KPI83888.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL51 protein Astro_capsid_p PF12226.8 KPI83888.1 - 0.71 9.0 2.0 3.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Myc_N PF01056.18 KPI83888.1 - 3.5 7.4 5.6 2.7 7.8 1.3 2.3 3 0 0 3 3 3 0 Myc amino-terminal region TFIIE-A_C PF11521.8 KPI83888.1 - 3.8 7.9 15.3 4.4 7.7 3.3 2.8 2 1 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Mem_trans PF03547.18 KPI83889.1 - 2.1e-25 88.9 10.0 4.9e-21 74.6 0.4 2.8 2 1 0 2 2 2 2 Membrane transport protein MFS_MOT1 PF16983.5 KPI83889.1 - 0.046 14.1 0.9 0.046 14.1 0.9 3.1 4 0 0 4 4 4 0 Molybdate transporter of MFS superfamily Peptidase_U4 PF03419.13 KPI83889.1 - 0.39 10.0 12.9 0.28 10.4 1.9 2.3 2 0 0 2 2 2 0 Sporulation factor SpoIIGA V-SNARE_C PF12352.8 KPI83890.1 - 6.5e-11 42.4 6.7 1.1e-10 41.6 1.9 3.1 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KPI83890.1 - 6.5e-07 29.2 0.0 8.2e-06 25.6 0.0 2.3 2 0 0 2 2 2 1 Sec20 Prefoldin PF02996.17 KPI83890.1 - 0.12 12.2 4.6 2.2 8.2 1.8 2.4 2 1 0 2 2 2 0 Prefoldin subunit zf-C4H2 PF10146.9 KPI83890.1 - 0.24 11.7 2.0 4.6 7.5 0.0 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein DUF2203 PF09969.9 KPI83890.1 - 0.31 11.7 5.7 0.6 10.8 2.2 2.4 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Flot PF15975.5 KPI83890.1 - 0.38 11.0 5.3 2.8 8.2 0.3 2.3 2 0 0 2 2 2 0 Flotillin MCU PF04678.13 KPI83890.1 - 7.3 6.6 6.8 28 4.7 3.6 2.1 1 1 1 2 2 2 0 Mitochondrial calcium uniporter DUF1691 PF07950.11 KPI83891.1 - 0.0021 18.7 0.5 0.067 13.9 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) SRP_TPR_like PF17004.5 KPI83892.1 - 2.1e-13 50.3 3.5 5.8e-13 48.9 3.5 1.8 1 0 0 1 1 1 1 Putative TPR-like repeat ANAPC3 PF12895.7 KPI83892.1 - 1.2e-07 31.8 14.8 0.00011 22.3 5.4 5.0 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KPI83892.1 - 3.9e-07 30.5 21.6 0.011 16.3 0.1 7.5 6 2 2 8 8 8 3 Tetratricopeptide repeat SRP72 PF08492.12 KPI83892.1 - 3.2e-06 27.5 0.8 3.2e-06 27.5 0.8 2.6 3 0 0 3 3 2 1 SRP72 RNA-binding domain TPR_6 PF13174.6 KPI83892.1 - 4e-05 24.0 13.3 1.9 9.3 0.1 6.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI83892.1 - 0.0002 21.9 24.7 0.52 11.3 0.8 8.3 7 2 2 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI83892.1 - 0.00021 21.2 26.8 0.84 9.9 0.4 6.9 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83892.1 - 0.00096 18.9 9.3 0.92 9.4 0.2 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83892.1 - 0.0024 18.0 9.1 4.4 7.8 0.2 4.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI83892.1 - 0.0055 17.3 28.1 0.19 12.4 0.6 6.5 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI83892.1 - 0.033 14.5 3.8 10 6.8 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KPI83892.1 - 0.079 13.6 15.8 2 9.3 0.1 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI83892.1 - 0.1 12.7 9.2 11 6.2 0.0 4.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KPI83892.1 - 0.2 11.8 0.0 0.2 11.8 0.0 5.2 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI83892.1 - 0.47 10.6 14.3 3.1 8.1 2.7 4.9 5 1 0 5 5 5 0 Tetratricopeptide repeat Coatomer_E PF04733.14 KPI83892.1 - 0.75 9.1 7.5 1.2 8.5 0.1 3.9 4 0 0 4 4 4 0 Coatomer epsilon subunit ABC_tran PF00005.27 KPI83893.1 - 4e-44 150.5 0.0 1.1e-20 74.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 KPI83893.1 - 2.4e-21 75.6 3.0 2.4e-21 75.6 3.0 3.0 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 KPI83893.1 - 9.6e-21 74.9 0.0 5.4e-05 23.2 0.0 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI83893.1 - 1.6e-11 44.1 2.0 0.0035 16.8 0.0 5.0 5 0 0 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KPI83893.1 - 8.4e-08 33.0 4.8 0.024 15.2 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.6 KPI83893.1 - 2e-07 31.3 0.0 0.039 14.1 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KPI83893.1 - 4.3e-07 30.5 0.0 0.0053 17.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 KPI83893.1 - 4.6e-07 30.2 0.0 0.013 15.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KPI83893.1 - 9.1e-07 29.4 0.0 0.0069 16.8 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KPI83893.1 - 4.7e-06 27.2 0.0 0.073 13.6 0.0 3.0 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 KPI83893.1 - 5.1e-06 26.8 0.1 0.02 15.3 0.0 3.1 3 0 0 3 3 3 1 RNA helicase AAA_29 PF13555.6 KPI83893.1 - 6e-06 25.9 0.1 0.19 11.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 KPI83893.1 - 2.3e-05 24.3 2.1 0.38 10.4 0.0 3.8 4 0 0 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 KPI83893.1 - 4.7e-05 23.4 0.2 0.053 13.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) TsaE PF02367.17 KPI83893.1 - 4.9e-05 23.3 0.1 0.0031 17.5 0.0 2.8 2 1 1 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KPI83893.1 - 5.5e-05 23.2 0.0 1 9.4 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_22 PF13401.6 KPI83893.1 - 9.2e-05 22.7 0.0 0.11 12.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KPI83893.1 - 0.00013 21.9 0.0 0.66 9.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 KPI83893.1 - 0.00018 21.3 0.0 0.1 12.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 KPI83893.1 - 0.00019 21.4 0.1 0.45 10.4 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_25 PF13481.6 KPI83893.1 - 0.00021 20.9 0.0 1.4 8.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 KPI83893.1 - 0.00065 19.3 0.0 0.16 11.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Rad17 PF03215.15 KPI83893.1 - 0.0007 19.6 0.1 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain MMR_HSR1 PF01926.23 KPI83893.1 - 0.00092 19.3 0.0 1.2 9.2 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 KPI83893.1 - 0.002 17.9 0.4 1.2 8.8 0.0 3.4 3 1 0 3 3 2 1 AAA domain PduV-EutP PF10662.9 KPI83893.1 - 0.0027 17.4 0.0 0.55 10.0 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 KPI83893.1 - 0.012 14.8 0.0 2.3 7.4 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 KPI83893.1 - 0.013 14.9 0.0 6.3 6.1 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI dNK PF01712.19 KPI83893.1 - 0.016 15.1 0.0 0.69 9.7 0.0 2.5 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_27 PF13514.6 KPI83893.1 - 0.017 14.7 0.0 19 4.7 0.0 3.4 3 1 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 KPI83893.1 - 0.022 14.5 0.0 2.6 7.7 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein cobW PF02492.19 KPI83893.1 - 0.022 14.3 0.1 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 KPI83893.1 - 0.023 14.9 0.0 1.4 9.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RuvB_N PF05496.12 KPI83893.1 - 0.024 14.4 0.1 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain HSBP1 PF06825.12 KPI83893.1 - 0.026 14.3 1.0 0.056 13.3 0.0 2.0 2 0 0 2 2 1 0 Heat shock factor binding protein 1 SRP54 PF00448.22 KPI83893.1 - 0.035 13.7 0.2 0.76 9.4 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 KPI83893.1 - 0.038 13.3 0.0 0.73 9.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin MeaB PF03308.16 KPI83893.1 - 0.038 13.0 0.3 0.85 8.5 0.0 2.4 3 0 0 3 3 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 KPI83893.1 - 0.04 13.8 0.0 4.8 7.0 0.0 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_13 PF13166.6 KPI83893.1 - 0.041 12.5 5.6 2.5 6.7 0.0 3.9 4 0 0 4 4 3 0 AAA domain NTPase_1 PF03266.15 KPI83893.1 - 0.043 13.7 0.1 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_PrkA PF08298.11 KPI83893.1 - 0.097 11.6 0.0 3.3 6.5 0.0 2.6 3 0 0 3 3 3 0 PrkA AAA domain ATP-synt_ab PF00006.25 KPI83893.1 - 0.13 11.9 0.0 8.9 5.9 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Vps53_N PF04100.12 KPI83894.1 - 1.4e-66 225.1 9.7 1.9e-66 224.6 9.7 1.1 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF1664 PF07889.12 KPI83894.1 - 1.4 9.0 4.4 1.7 8.7 2.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Com_YlbF PF06133.11 KPI83894.1 - 3.8 8.2 8.8 0.61 10.7 2.8 2.4 1 1 1 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA BT1 PF03092.16 KPI83895.1 - 4e-177 589.6 11.1 5.1e-177 589.3 11.1 1.1 1 0 0 1 1 1 1 BT1 family TYA PF01021.19 KPI83897.1 - 0.048 14.0 1.3 0.93 9.9 1.2 2.2 2 0 0 2 2 2 0 TYA transposon protein Golgin_A5 PF09787.9 KPI83898.1 - 0.00053 19.5 0.0 0.00053 19.5 0.0 4.7 4 1 1 5 5 5 3 Golgin subfamily A member 5 Filament PF00038.21 KPI83898.1 - 0.014 15.0 2.3 0.014 15.0 2.3 3.3 3 1 0 4 4 4 0 Intermediate filament protein Laminin_II PF06009.12 KPI83898.1 - 0.021 14.8 25.4 0.088 12.8 3.2 3.9 4 0 0 4 4 4 0 Laminin Domain II DUF2525 PF10733.9 KPI83898.1 - 0.096 13.0 0.8 0.43 10.9 0.8 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2525) HALZ PF02183.18 KPI83898.1 - 4.5 7.6 8.7 24 5.3 0.9 3.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper WD40 PF00400.32 KPI83899.1 - 1.3e-14 54.4 7.6 0.0028 18.5 0.2 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI83899.1 - 2.5e-05 24.5 0.0 0.58 10.5 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI83899.1 - 0.0015 17.3 0.2 0.0052 15.5 0.0 2.0 3 0 0 3 3 3 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 KPI83899.1 - 0.016 14.6 0.0 1.2 8.3 0.0 2.5 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal RAB3GAP2_N PF14655.6 KPI83899.1 - 0.091 12.0 0.0 3 7.0 0.0 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4746 PF15928.5 KPI83899.1 - 4.5 6.6 7.8 7.2 5.9 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) IQ PF00612.27 KPI83900.1 - 3.8e-26 88.4 183.9 9.6e-05 21.9 0.9 23.2 24 0 0 24 24 24 15 IQ calmodulin-binding motif TPR_1 PF00515.28 KPI83900.1 - 2.1e-08 33.6 2.0 0.34 10.8 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI83900.1 - 0.00083 19.4 0.2 7.3 7.1 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KPI83900.1 - 0.0013 18.6 1.7 0.021 14.7 0.1 8.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI83900.1 - 0.0038 17.2 19.2 1.5 9.1 0.2 7.9 7 0 0 7 7 7 2 Tetratricopeptide repeat IQCJ-SCHIP1 PF15157.6 KPI83900.1 - 0.69 9.7 9.0 4 7.3 0.3 4.2 3 1 1 4 4 4 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Tau95 PF09734.9 KPI83901.1 - 4.5e-18 66.4 0.0 1.4e-17 64.8 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain TFIIB_C_1 PF18542.1 KPI83902.1 - 2.9e-42 142.6 2.6 2.9e-42 142.6 2.6 1.8 2 0 0 2 2 2 1 Transcription factor IIB C-terminal module 1 TF_Zn_Ribbon PF08271.12 KPI83902.1 - 1e-06 28.1 0.5 1.9e-06 27.3 0.5 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding cNMP_binding PF00027.29 KPI83904.1 - 0.0037 17.3 0.0 0.017 15.2 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Pkinase PF00069.25 KPI83905.1 - 2.1e-58 197.8 0.0 3.3e-58 197.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83905.1 - 3.6e-40 137.9 0.0 6.1e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KPI83905.1 - 5.1e-28 97.0 1.7 5.3e-13 48.9 0.1 3.0 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain PAS PF00989.25 KPI83905.1 - 1.2e-07 31.7 0.0 4e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 PAS fold Kinase-like PF14531.6 KPI83905.1 - 1.4e-07 31.1 0.0 1.9e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PAS_9 PF13426.7 KPI83905.1 - 4.9e-05 23.5 0.0 0.00019 21.6 0.0 2.0 1 0 0 1 1 1 1 PAS domain Shikimate_DH PF01488.20 KPI83905.1 - 0.092 12.8 0.4 1.4 9.0 0.0 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase RIO1 PF01163.22 KPI83905.1 - 0.22 11.1 0.3 0.5 9.9 0.0 1.7 2 0 0 2 2 2 0 RIO1 family VCBS PF13517.6 KPI83906.1 - 1.5e-07 31.9 0.0 0.0015 19.1 0.0 3.1 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KPI83906.1 - 7.1e-06 26.0 0.9 0.0011 19.1 0.0 3.4 3 0 0 3 3 3 1 FG-GAP repeat TcdB_toxin_midN PF12256.8 KPI83906.1 - 0.12 11.8 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region DUF676 PF05057.14 KPI83907.1 - 2.9e-14 53.1 0.0 1.3e-13 51.0 0.0 1.9 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 KPI83907.1 - 0.0021 17.9 0.0 0.0038 17.1 0.0 1.5 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 KPI83907.1 - 0.084 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 KPI83907.1 - 0.091 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 KPI83907.1 - 0.64 10.6 11.7 1.3 9.6 11.7 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family NTP_transferase PF00483.23 KPI83908.1 - 0.00017 21.3 0.0 0.00046 19.9 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 KPI83908.1 - 0.00089 18.3 0.6 0.0013 17.8 0.6 1.2 1 0 0 1 1 1 1 L-fucokinase NTP_transf_3 PF12804.7 KPI83908.1 - 0.014 15.8 0.0 0.059 13.7 0.0 2.3 1 1 0 1 1 1 0 MobA-like NTP transferase domain Hexapep PF00132.24 KPI83908.1 - 0.018 14.8 9.9 0.13 12.0 2.0 3.5 1 1 3 4 4 4 0 Bacterial transferase hexapeptide (six repeats) ATP-synt_ab PF00006.25 KPI83909.1 - 3.3e-67 226.3 0.0 4.3e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KPI83909.1 - 1.9e-14 53.9 0.8 3.8e-14 52.9 0.8 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain 2-oxoacid_dh PF00198.23 KPI83910.1 - 7.7e-81 270.9 0.2 9.6e-81 270.6 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KPI83910.1 - 3.5e-20 71.6 1.6 5.8e-20 70.9 1.6 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KPI83910.1 - 1.9e-05 24.4 0.3 0.065 13.1 0.1 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like GCV_H PF01597.19 KPI83910.1 - 0.01 15.7 0.6 0.023 14.6 0.6 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_D23 PF16576.5 KPI83910.1 - 0.097 11.9 0.1 0.68 9.1 0.0 1.9 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Rft-1 PF04506.13 KPI83911.1 - 9.7e-45 153.3 4.7 4.8e-39 134.5 2.1 2.3 2 0 0 2 2 2 2 Rft protein GCD14 PF08704.10 KPI83912.1 - 6.1e-64 216.1 0.1 2.2e-36 125.8 0.0 3.1 1 1 2 3 3 3 3 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 KPI83912.1 - 9.3e-08 32.0 0.0 2.7e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI83912.1 - 1.3e-05 25.8 0.0 0.0011 19.6 0.1 2.5 1 1 1 2 2 2 1 Methyltransferase domain GCD14_N PF14801.6 KPI83912.1 - 2e-05 24.3 0.1 4.2e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term PCMT PF01135.19 KPI83912.1 - 2.8e-05 24.0 0.0 6.4e-05 22.8 0.0 1.5 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fibrillarin PF01269.17 KPI83912.1 - 0.0022 17.1 0.0 1.8 7.6 0.0 2.2 2 0 0 2 2 2 2 Fibrillarin Methyltransf_11 PF08241.12 KPI83912.1 - 0.0081 16.8 0.1 0.038 14.6 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI83912.1 - 0.021 14.2 0.0 0.27 10.5 0.0 2.0 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KPI83912.1 - 0.025 15.3 0.0 0.12 13.1 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 KPI83912.1 - 0.036 13.7 0.1 0.18 11.4 0.0 2.2 2 1 0 2 2 2 0 16S rRNA methyltransferase RsmB/F MTS PF05175.14 KPI83912.1 - 0.056 13.0 0.0 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_24 PF13578.6 KPI83912.1 - 0.09 13.8 0.0 0.21 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 KPI83912.1 - 0.16 11.3 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 KPI83912.1 - 0.16 11.0 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase WW PF00397.26 KPI83913.1 - 2.1e-09 37.3 1.4 4.7e-09 36.2 1.4 1.6 1 0 0 1 1 1 1 WW domain NUDIX_2 PF13869.6 KPI83913.1 - 0.15 11.6 0.3 0.5 9.9 0.3 1.9 1 0 0 1 1 1 0 Nucleotide hydrolase phage_tail_N PF08400.10 KPI83913.1 - 3.1 7.8 5.8 0.65 10.0 0.6 2.6 2 0 0 2 2 2 0 Prophage tail fibre N-terminal MCM PF00493.23 KPI83914.1 - 4.8e-91 303.8 0.3 6.9e-91 303.3 0.3 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KPI83914.1 - 3.5e-35 120.6 0.7 6.4e-35 119.8 0.7 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KPI83914.1 - 7.3e-22 77.6 4.2 1.5e-21 76.6 2.7 2.3 3 0 0 3 3 3 1 MCM AAA-lid domain MCM6_C PF18263.1 KPI83914.1 - 7.4e-10 39.0 0.0 1.7e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 KPI83914.1 - 1.2e-06 28.1 0.0 3.6e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 KPI83914.1 - 5.1e-06 27.0 0.0 1.2e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 KPI83914.1 - 0.0029 17.6 0.1 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KPI83914.1 - 0.0069 16.2 0.0 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KPI83914.1 - 0.013 15.2 0.1 0.029 14.1 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF188 PF02639.14 KPI83914.1 - 0.24 11.1 1.0 14 5.3 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Helicase_C_2 PF13307.6 KPI83915.1 - 1.3e-41 142.6 0.0 2.3e-41 141.8 0.0 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 KPI83915.1 - 1.5e-20 73.5 0.1 2.3e-08 33.9 0.0 4.3 4 0 0 4 4 4 4 DEAD_2 ResIII PF04851.15 KPI83915.1 - 0.016 15.3 0.2 6 6.8 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MNR PF15718.5 KPI83915.1 - 0.17 10.0 10.3 0.3 9.2 10.3 1.3 1 0 0 1 1 1 0 Protein moonraker Methyltransf_31 PF13847.6 KPI83916.1 - 2.5e-08 33.9 0.0 3.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI83916.1 - 7.4e-08 33.0 0.1 2.1e-07 31.6 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KPI83916.1 - 0.00017 21.4 0.6 0.00034 20.4 0.6 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 KPI83916.1 - 0.00063 20.4 0.0 0.0023 18.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 KPI83916.1 - 0.0015 17.6 0.1 0.0024 16.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 KPI83916.1 - 0.004 16.6 0.0 0.0071 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KPI83916.1 - 0.0052 17.5 0.0 0.01 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KPI83916.1 - 0.018 15.1 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase tRNA_U5-meth_tr PF05958.11 KPI83916.1 - 0.019 13.9 0.0 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase MTS PF05175.14 KPI83916.1 - 0.034 13.7 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 KPI83916.1 - 0.047 13.5 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MeaB PF03308.16 KPI83917.1 - 4.5e-76 255.4 0.2 5.8e-76 255.0 0.2 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 KPI83917.1 - 4.2e-08 33.0 0.1 1.2e-07 31.5 0.1 1.7 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ParA PF10609.9 KPI83917.1 - 0.00041 19.9 0.2 0.26 10.7 0.0 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KPI83917.1 - 0.0027 17.8 0.0 0.0048 17.0 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 KPI83917.1 - 0.0032 17.8 1.0 0.16 12.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 KPI83917.1 - 0.0066 16.1 0.1 0.06 13.0 0.1 2.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain GTP_EFTU PF00009.27 KPI83917.1 - 0.0091 15.5 0.0 3.8 7.0 0.1 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 KPI83917.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KPI83917.1 - 0.013 15.9 0.1 0.027 14.9 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 KPI83917.1 - 0.013 15.2 0.0 0.032 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KPI83917.1 - 0.015 15.8 0.0 0.035 14.6 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.7 KPI83917.1 - 0.021 13.7 0.0 0.042 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA-like domain AAA_28 PF13521.6 KPI83917.1 - 0.033 14.4 0.1 0.11 12.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KPI83917.1 - 0.045 13.7 0.1 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 NTPase IstB_IS21 PF01695.17 KPI83917.1 - 0.054 13.2 0.0 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 KPI83917.1 - 0.091 12.0 0.0 0.3 10.3 0.0 1.9 1 0 0 1 1 1 0 Zeta toxin ATP_bind_1 PF03029.17 KPI83917.1 - 0.097 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein KTI12 PF08433.10 KPI83917.1 - 0.098 12.1 0.1 5.2 6.4 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 MMR_HSR1 PF01926.23 KPI83917.1 - 0.11 12.6 0.1 0.32 11.1 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 KPI83917.1 - 0.16 11.7 0.5 0.79 9.4 0.5 2.3 1 1 0 1 1 1 0 AAA domain TPR_12 PF13424.6 KPI83920.1 - 0.87 9.9 3.7 30 5.0 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat CRT-like PF08627.10 KPI83921.1 - 0.021 13.8 14.2 0.55 9.1 0.3 3.9 3 1 0 3 3 3 0 CRT-like, chloroquine-resistance transporter-like CRT-like PF08627.10 KPI83922.1 - 0.0044 16.0 6.0 0.0044 16.0 6.0 3.0 2 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like DUF4492 PF14899.6 KPI83922.1 - 0.12 12.4 2.8 0.34 10.9 2.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4492) EIID-AGA PF03613.14 KPI83922.1 - 4.6 6.3 10.7 0.19 10.9 0.1 2.4 2 1 0 3 3 3 0 PTS system mannose/fructose/sorbose family IID component AAA_16 PF13191.6 KPI83923.1 - 0.0045 17.4 0.1 0.017 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 KPI83923.1 - 0.012 15.6 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 KPI83923.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 recA bacterial DNA recombination protein TIP49 PF06068.13 KPI83923.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 KPI83923.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 KPI83923.1 - 0.21 10.6 0.0 0.35 9.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4795 PF16043.5 KPI83926.1 - 0.0038 16.8 44.1 0.31 10.6 0.8 6.3 3 2 3 6 6 6 3 Domain of unknown function (DUF4795) HWE_HK PF07536.14 KPI83926.1 - 0.012 16.3 4.2 0.042 14.6 0.4 3.4 2 0 0 2 2 2 0 HWE histidine kinase HCMV_UL139 PF12507.8 KPI83926.1 - 0.025 14.9 0.3 0.025 14.9 0.3 3.0 4 1 0 4 4 3 0 Human Cytomegalovirus UL139 protein CCDC53 PF10152.9 KPI83926.1 - 0.073 13.5 0.2 0.073 13.5 0.2 4.0 3 1 0 3 3 2 0 Subunit CCDC53 of WASH complex PatG_C PF18065.1 KPI83926.1 - 0.1 12.5 0.3 12 5.9 0.0 3.4 3 0 0 3 3 3 0 PatG C-terminal Img2 PF05046.14 KPI83926.1 - 0.19 12.0 0.2 1.5 9.2 0.1 2.5 1 1 1 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) Tropomyosin_1 PF12718.7 KPI83926.1 - 0.56 10.3 48.2 0.18 12.0 2.6 5.7 4 2 1 5 5 4 0 Tropomyosin like Baculo_PEP_C PF04513.12 KPI83926.1 - 0.56 10.2 22.3 0.5 10.4 0.9 5.3 6 1 0 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF724 PF05266.14 KPI83926.1 - 0.95 9.3 24.2 1.2 8.9 0.2 4.8 3 2 0 4 4 4 0 Protein of unknown function (DUF724) COG2 PF06148.11 KPI83926.1 - 2 8.5 26.1 0.14 12.3 4.6 5.1 5 0 0 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin_2 PF01920.20 KPI83926.1 - 2.6 8.1 25.8 0.79 9.7 0.5 7.1 5 2 2 7 7 7 0 Prefoldin subunit AAA_13 PF13166.6 KPI83926.1 - 2.6 6.6 20.9 1.5 7.3 0.6 3.4 3 1 0 3 3 3 0 AAA domain YabA PF06156.13 KPI83926.1 - 3 8.6 25.2 2.7 8.7 0.6 6.5 3 2 4 7 7 7 0 Initiation control protein YabA DUF1664 PF07889.12 KPI83926.1 - 3.8 7.6 19.0 1.2 9.1 2.3 5.1 5 1 0 5 5 5 0 Protein of unknown function (DUF1664) NleF_casp_inhib PF16809.5 KPI83926.1 - 4.1 7.3 7.3 6 6.8 0.1 3.6 3 1 1 4 4 4 0 NleF caspase inhibitor GAS PF13851.6 KPI83926.1 - 6.4 6.1 40.7 0.021 14.2 5.2 5.1 4 2 0 4 4 4 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 KPI83926.1 - 9.9 4.9 43.6 0.2 10.5 9.0 5.1 4 2 0 4 4 4 0 Spc7 kinetochore protein NIF PF03031.18 KPI83927.1 - 1e-09 38.3 0.0 0.00014 21.7 0.0 2.1 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase Adeno_PV PF03910.13 KPI83927.1 - 0.44 9.2 2.4 0.62 8.7 2.4 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV PSS PF03034.15 KPI83928.1 - 1.2e-94 317.1 10.9 1.7e-94 316.6 10.9 1.2 1 0 0 1 1 1 1 Phosphatidyl serine synthase PAP2 PF01569.21 KPI83928.1 - 9.4 6.0 12.4 0.32 10.8 0.6 3.6 3 1 1 4 4 4 0 PAP2 superfamily Carb_kinase PF01256.17 KPI83929.1 - 6.9e-44 150.2 6.6 1e-32 113.6 0.1 2.5 2 1 0 2 2 2 2 Carbohydrate kinase YjeF_N PF03853.15 KPI83929.1 - 9.6e-43 146.0 0.6 2.6e-42 144.6 0.1 2.0 2 0 0 2 2 2 1 YjeF-related protein N-terminus PAP_central PF04928.17 KPI83930.1 - 6.8e-56 189.0 0.0 1.1e-55 188.3 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 KPI83930.1 - 2.9e-30 105.1 0.0 5.9e-30 104.1 0.0 1.5 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 KPI83930.1 - 3.2e-05 24.1 0.0 7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain DNA_pol_B_palm PF14792.6 KPI83930.1 - 0.0068 16.6 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm FYVE PF01363.21 KPI83931.1 - 1e-14 54.4 14.9 1.2e-13 50.9 11.6 3.2 2 1 0 2 2 2 1 FYVE zinc finger Ras PF00071.22 KPI83931.1 - 6.1e-12 45.4 0.0 1.1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI83931.1 - 2.8e-09 37.2 0.0 5.4e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 KPI83931.1 - 0.001 18.9 0.3 0.0031 17.4 0.0 2.0 2 0 0 2 2 2 1 F-box-like AAA_7 PF12775.7 KPI83931.1 - 0.0021 17.6 0.0 0.011 15.2 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region Zf_RING PF16744.5 KPI83931.1 - 0.02 15.0 2.9 0.14 12.3 0.3 2.6 2 0 0 2 2 2 0 KIAA1045 RING finger F-box PF00646.33 KPI83931.1 - 0.11 12.4 0.0 0.45 10.5 0.0 2.0 1 0 0 1 1 1 0 F-box domain AAA_16 PF13191.6 KPI83931.1 - 0.13 12.6 0.2 0.51 10.7 0.2 2.0 1 0 0 1 1 1 0 AAA ATPase domain Enolase_C PF00113.22 KPI83932.1 - 1.3e-129 431.7 0.0 1.8e-129 431.2 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KPI83932.1 - 2.6e-58 195.9 0.1 4.7e-58 195.0 0.1 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KPI83932.1 - 2e-08 34.1 0.0 2.9e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KPI83932.1 - 0.00035 19.8 0.6 0.00061 19.0 0.1 1.6 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus NAD_binding_5 PF07994.12 KPI83934.1 - 3.8e-136 453.7 0.0 4.4e-136 453.5 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KPI83934.1 - 6.8e-45 151.8 0.0 1.4e-44 150.8 0.0 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Harakiri PF15196.6 KPI83935.1 - 0.081 13.4 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Activator of apoptosis harakiri tRNA-synt_1b PF00579.25 KPI83936.1 - 3e-53 181.1 0.0 7e-48 163.4 0.0 2.8 2 1 0 2 2 2 2 tRNA synthetases class I (W and Y) EMP24_GP25L PF01105.24 KPI83938.1 - 1.8e-20 73.7 0.1 2.2e-20 73.3 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD PP2C_2 PF13672.6 KPI83938.1 - 0.13 11.9 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C VMA21 PF09446.10 KPI83939.1 - 0.031 14.4 6.1 3.3 7.9 0.5 3.2 2 1 0 2 2 2 0 VMA21-like domain Pkinase PF00069.25 KPI83940.1 - 1.2e-61 208.4 0.0 1.5e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83940.1 - 5e-44 150.5 0.0 6.4e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI83940.1 - 3.5e-08 33.1 0.0 7.9e-08 31.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI83940.1 - 0.0015 17.4 0.0 0.0026 16.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase WD40 PF00400.32 KPI83942.1 - 0.001 19.8 17.9 12 6.9 0.0 7.5 9 0 0 9 9 9 3 WD domain, G-beta repeat ZapB PF06005.12 KPI83942.1 - 0.0049 17.3 2.4 0.0049 17.3 2.4 7.8 8 2 0 8 8 8 1 Cell division protein ZapB EMP24_GP25L PF01105.24 KPI83942.1 - 0.85 9.5 9.8 4.7 7.1 0.8 3.7 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD C2 PF00168.30 KPI83943.1 - 1.9e-09 37.7 0.0 0.0018 18.5 0.0 2.5 2 0 0 2 2 2 2 C2 domain Rubredoxin PF00301.20 KPI83943.1 - 0.038 14.0 0.2 0.11 12.5 0.2 1.8 1 0 0 1 1 1 0 Rubredoxin LRR_4 PF12799.7 KPI83944.1 - 2.1e-06 27.9 2.6 0.0012 19.2 0.7 3.1 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI83944.1 - 0.00089 19.0 2.6 0.032 14.0 0.1 2.7 2 1 0 2 2 2 2 Leucine rich repeat SpoU_methylase PF00588.19 KPI83945.1 - 3.6e-14 53.1 0.0 9.4e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 SpoU rRNA Methylase family Hid1 PF12722.7 KPI83946.1 - 0.063 11.4 3.1 0.094 10.8 3.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 KPI83946.1 - 1.7 7.3 7.6 2.4 6.8 7.6 1.2 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 KPI83947.1 - 4.2e-61 206.6 0.0 5e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83947.1 - 1.6e-37 129.2 0.0 2.1e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI83947.1 - 0.0024 17.3 0.0 0.0052 16.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 KPI83947.1 - 0.0031 17.2 0.1 0.32 10.6 0.0 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KPI83947.1 - 0.031 13.1 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Methyltransf_33 PF10017.9 KPI83947.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent NMU PF02070.15 KPI83947.1 - 7.2 6.6 6.2 7.4 6.5 1.7 2.4 2 0 0 2 2 2 0 Neuromedin U Ham1p_like PF01725.16 KPI83948.1 - 0.0085 16.0 1.3 0.014 15.4 0.5 1.6 1 1 1 2 2 2 1 Ham1 family AcylCoA_dehyd_C PF12186.8 KPI83948.1 - 0.067 13.3 3.9 1.7 8.8 0.3 2.4 2 1 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal ABC_tran_CTD PF16326.5 KPI83948.1 - 0.32 11.3 0.4 0.32 11.3 0.4 3.5 2 2 0 3 3 3 0 ABC transporter C-terminal domain HsbA PF12296.8 KPI83949.1 - 0.032 14.7 1.5 5 7.6 0.3 2.3 2 0 0 2 2 2 0 Hydrophobic surface binding protein A DUF2682 PF10909.8 KPI83949.1 - 0.043 14.3 0.1 0.52 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2682) ACOX PF01756.19 KPI83949.1 - 0.073 12.6 0.1 0.17 11.4 0.1 1.8 1 1 0 1 1 1 0 Acyl-CoA oxidase DUF4715 PF15835.5 KPI83949.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) MobC PF05713.11 KPI83949.1 - 0.27 11.7 1.7 1.5 9.3 0.2 2.7 3 0 0 3 3 3 0 Bacterial mobilisation protein (MobC) DUF4164 PF13747.6 KPI83949.1 - 1.2 9.4 5.3 20 5.6 0.0 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF4164) Cullin PF00888.22 KPI83950.1 - 9.2e-85 285.5 0.0 1.2e-84 285.2 0.0 1.0 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KPI83950.1 - 9.1e-21 73.7 1.8 2e-20 72.6 0.7 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain FRB_dom PF08771.11 KPI83950.1 - 0.012 16.0 0.6 0.048 14.1 0.6 2.1 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain DEAD_2 PF06733.15 KPI83951.1 - 1.1e-39 135.8 0.0 3.1e-39 134.4 0.0 1.8 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 KPI83951.1 - 1.2e-39 136.3 0.0 2.3e-39 135.3 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 KPI83951.1 - 5.5e-34 117.5 0.6 1.6e-28 99.7 0.1 2.6 2 0 0 2 2 2 2 Helical and beta-bridge domain DEAD PF00270.29 KPI83951.1 - 8.7e-05 22.4 0.2 0.0091 15.8 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 KPI83951.1 - 0.00058 19.9 0.6 0.0031 17.5 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KPI83951.1 - 0.03 14.3 0.8 1.8 8.5 0.1 2.7 2 0 0 2 2 2 0 Flavivirus DEAD domain AAA_19 PF13245.6 KPI83951.1 - 0.034 14.5 0.1 0.12 12.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KPI83951.1 - 0.046 14.0 0.5 0.32 11.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain SAPIS-gp6 PF16722.5 KPI83951.1 - 0.11 13.0 0.2 0.23 11.9 0.2 1.5 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus DHHC PF01529.20 KPI83952.1 - 8.9e-13 48.5 10.3 8.9e-13 48.5 10.3 3.1 3 1 0 3 3 3 1 DHHC palmitoyltransferase NicO PF03824.16 KPI83952.1 - 0.0013 18.2 2.1 0.0018 17.7 0.1 2.0 2 1 0 2 2 2 1 High-affinity nickel-transport protein Tmemb_9 PF05434.11 KPI83952.1 - 0.9 9.4 4.2 16 5.4 2.9 2.3 1 1 1 2 2 2 0 TMEM9 WD40 PF00400.32 KPI83953.1 - 1.6e-55 183.8 29.3 3.6e-08 33.9 0.0 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI83953.1 - 8.2e-21 74.1 5.6 0.0021 18.3 0.0 6.3 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 KPI83953.1 - 3.9e-11 43.3 0.0 8.2e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 KPI83953.1 - 5.7e-09 35.4 0.5 0.056 12.4 0.0 4.4 2 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KPI83953.1 - 2.2e-07 31.0 0.4 0.04 13.8 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KPI83953.1 - 6.8e-07 28.9 0.0 0.2 10.9 0.0 3.4 2 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 KPI83953.1 - 5.6e-06 26.2 2.3 1.1 9.3 0.1 4.9 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 KPI83953.1 - 0.0005 19.5 0.4 0.37 10.1 0.0 3.8 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nse5 PF08691.10 KPI83953.1 - 0.16 10.6 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 FA_desaturase PF00487.24 KPI83954.1 - 1.6e-17 64.2 18.1 1.6e-17 64.2 18.1 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 KPI83954.1 - 6.9e-08 32.5 0.3 7e-07 29.3 0.1 2.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF2269 PF10027.9 KPI83954.1 - 0.046 13.8 0.2 0.11 12.6 0.2 1.6 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) Trimer_CC PF08954.11 KPI83954.1 - 0.1 12.2 0.5 0.18 11.4 0.5 1.3 1 0 0 1 1 1 0 Trimerisation motif Cob_adeno_trans PF01923.18 KPI83955.1 - 1.6e-53 181.2 0.9 2.4e-53 180.6 0.1 1.6 2 0 0 2 2 2 1 Cobalamin adenosyltransferase DUF4345 PF14248.6 KPI83956.1 - 0.0067 16.3 3.7 0.24 11.3 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4345) DUF2607 PF10795.9 KPI83956.1 - 0.027 14.6 0.0 0.25 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2607) AAA PF00004.29 KPI83957.1 - 0.0056 17.1 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI83957.1 - 0.044 14.2 0.0 0.066 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 KPI83957.1 - 0.058 13.4 0.0 0.36 10.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Torsin PF06309.11 KPI83957.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Torsin GRAM PF02893.20 KPI83958.1 - 6.5e-24 84.0 4.7 1.3e-14 54.0 0.5 2.2 2 0 0 2 2 2 2 GRAM domain Pkinase PF00069.25 KPI83960.1 - 7.5e-67 225.5 0.0 9.5e-67 225.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83960.1 - 1.8e-38 132.3 0.0 2.5e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 KPI83960.1 - 2.5e-31 107.7 0.0 7.8e-16 58.0 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 KPI83960.1 - 1e-07 31.6 0.0 4.8e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI83960.1 - 0.00026 19.9 0.0 0.00039 19.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI83960.1 - 0.0022 17.9 0.1 0.026 14.4 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI83960.1 - 0.0069 15.4 0.1 0.01 14.8 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain VID27 PF08553.10 KPI83961.1 - 1.1e-25 90.4 0.0 1.7e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain Pkinase PF00069.25 KPI83964.1 - 1.3e-21 77.2 0.0 7.4e-12 45.2 0.0 4.0 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI83964.1 - 6.4e-06 25.6 0.0 0.011 15.0 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Ribosomal_L6e PF01159.19 KPI83965.1 - 4.3e-31 107.7 1.1 6.3e-30 104.0 1.1 2.2 1 1 0 1 1 1 1 Ribosomal protein L6e KOW PF00467.29 KPI83965.1 - 0.022 14.7 0.0 0.1 12.6 0.0 2.1 1 1 1 2 2 2 0 KOW motif PTR2 PF00854.21 KPI83966.1 - 2.1e-33 115.7 5.2 3e-31 108.7 0.0 2.7 3 0 0 3 3 3 2 POT family MFS_1 PF07690.16 KPI83966.1 - 7.6e-06 25.1 33.1 4.3e-05 22.6 13.2 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily TPR_2 PF07719.17 KPI83967.1 - 0.00016 21.5 8.2 0.04 14.1 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI83967.1 - 0.0011 18.6 6.9 0.14 12.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI83967.1 - 0.011 16.0 4.4 0.12 12.6 1.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI83967.1 - 0.015 15.5 3.0 0.035 14.3 3.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 NYD-SP12_N PF15015.6 KPI83967.1 - 0.034 12.5 0.2 0.12 10.7 0.1 1.7 1 1 1 2 2 2 0 Spermatogenesis-associated, N-terminal DUF4765 PF15962.5 KPI83967.1 - 0.041 11.8 0.0 0.052 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4765) TPR_16 PF13432.6 KPI83967.1 - 0.069 13.8 3.7 0.15 12.7 0.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ERG4_ERG24 PF01222.17 KPI83969.1 - 2e-100 336.6 22.1 2.4e-100 336.3 22.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF2518 PF10726.9 KPI83969.1 - 0.07 12.8 1.4 0.23 11.1 0.2 2.1 2 0 0 2 2 2 0 Protein of function (DUF2518) RSRP PF17069.5 KPI83969.1 - 0.54 9.8 10.2 0.78 9.3 10.2 1.1 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Corona_nucleoca PF00937.18 KPI83969.1 - 3.3 6.7 7.9 5 6.0 7.9 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein WD40 PF00400.32 KPI83970.1 - 0.026 15.4 0.8 32 5.6 0.1 4.4 4 0 0 4 4 4 0 WD domain, G-beta repeat G6PD_N PF00479.22 KPI83972.1 - 1.3 9.6 7.0 0.29 11.7 1.7 2.6 1 1 1 2 2 2 0 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF948 PF06103.11 KPI83972.1 - 9.4 6.6 7.0 2.7 8.3 0.7 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) EF-hand_7 PF13499.6 KPI83973.1 - 0.014 15.9 0.3 0.1 13.0 0.0 2.6 3 1 1 4 4 4 0 EF-hand domain pair EF-hand_9 PF14658.6 KPI83973.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain BicD PF09730.9 KPI83974.1 - 0.0038 15.7 1.2 0.0051 15.3 1.2 1.1 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Spc7 PF08317.11 KPI83974.1 - 0.5 9.2 4.7 0.73 8.7 4.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Syntaphilin PF15290.6 KPI83974.1 - 0.5 10.0 5.0 0.98 9.0 4.4 1.7 2 0 0 2 2 2 0 Golgi-localised syntaxin-1-binding clamp IFT57 PF10498.9 KPI83975.1 - 1.9e-102 342.9 0.0 2.3e-102 342.7 0.0 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 HBM PF16591.5 KPI83975.1 - 2.5e-05 23.8 6.5 4.5e-05 23.0 6.5 1.4 1 0 0 1 1 1 1 Helical bimodular sensor domain Apolipoprotein PF01442.18 KPI83975.1 - 0.0021 18.0 12.4 0.0042 17.0 12.4 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Laminin_II PF06009.12 KPI83975.1 - 0.0085 16.1 10.8 0.024 14.7 0.7 2.6 2 1 1 3 3 2 1 Laminin Domain II Exonuc_VII_L PF02601.15 KPI83975.1 - 0.013 15.1 5.9 0.018 14.6 5.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 KPI83975.1 - 0.013 15.6 6.3 0.022 14.9 6.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CREPT PF16566.5 KPI83975.1 - 0.028 14.6 5.3 0.055 13.6 5.3 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2175 PF09943.9 KPI83975.1 - 0.035 14.4 4.6 0.27 11.5 1.7 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Laminin_I PF06008.14 KPI83975.1 - 0.045 13.5 9.8 0.096 12.4 9.7 1.6 1 1 0 1 1 1 0 Laminin Domain I KxDL PF10241.9 KPI83975.1 - 0.081 13.2 7.4 2.9 8.2 0.5 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein CR6_interact PF10147.9 KPI83975.1 - 0.097 12.4 5.5 0.2 11.4 5.5 1.6 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Spc7 PF08317.11 KPI83975.1 - 0.11 11.4 12.6 0.27 10.1 12.4 1.5 1 1 1 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KPI83975.1 - 0.11 12.6 9.6 0.52 10.4 0.3 2.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 KPI83975.1 - 0.14 12.2 11.2 1.2 9.2 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 KPI83975.1 - 0.16 11.7 5.8 0.28 11.0 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) YjbH PF06082.11 KPI83975.1 - 0.18 10.6 1.9 0.22 10.3 1.9 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH V_ATPase_I PF01496.19 KPI83975.1 - 0.23 9.4 5.6 0.31 8.9 5.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.6 KPI83975.1 - 0.39 10.0 11.1 0.22 10.8 8.9 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Prominin PF05478.11 KPI83975.1 - 0.4 8.6 5.8 0.53 8.2 5.8 1.1 1 0 0 1 1 1 0 Prominin Fzo_mitofusin PF04799.13 KPI83975.1 - 0.85 9.2 8.0 1.5 8.4 7.6 1.6 1 1 0 1 1 1 0 fzo-like conserved region DUF745 PF05335.13 KPI83975.1 - 1.1 8.9 9.5 16 5.1 10.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF745) AAA_13 PF13166.6 KPI83975.1 - 1.6 7.3 9.0 4.6 5.8 9.1 1.4 1 1 0 1 1 1 0 AAA domain Ead_Ea22 PF13935.6 KPI83975.1 - 1.7 9.3 6.8 9.9 6.8 6.3 2.4 1 1 0 1 1 1 0 Ead/Ea22-like protein DUF948 PF06103.11 KPI83975.1 - 2.8 8.3 7.0 45 4.4 6.9 2.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 KPI83975.1 - 3 8.2 7.2 2.6 8.4 1.5 2.7 1 1 0 2 2 2 0 ABC transporter C-terminal domain DUF883 PF05957.13 KPI83975.1 - 3.7 8.2 6.8 3.1 8.4 1.0 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2203 PF09969.9 KPI83975.1 - 5.9 7.6 7.2 44 4.8 7.2 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF4315 PF14193.6 KPI83975.1 - 6 7.0 8.3 9 6.4 6.8 2.2 2 1 0 2 2 1 0 Domain of unknown function (DUF4315) Atg14 PF10186.9 KPI83975.1 - 6.4 5.8 9.4 20 4.2 9.0 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ANAPC3 PF12895.7 KPI83977.1 - 4.8e-05 23.5 1.1 0.031 14.5 0.1 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 SRP68 PF16969.5 KPI83977.1 - 0.0018 17.4 0.5 0.0032 16.6 0.5 1.4 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 DUF1627 PF07789.12 KPI83977.1 - 0.013 15.2 0.0 0.035 13.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1627) TPR_2 PF07719.17 KPI83977.1 - 0.2 11.9 0.4 1.1e+02 3.3 0.0 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat Peptidase_M7 PF02031.16 KPI83978.1 - 0.0048 17.0 0.0 0.037 14.1 0.0 2.3 3 0 0 3 3 3 1 Streptomyces extracellular neutral proteinase (M7) family Tyr-DNA_phospho PF06087.12 KPI83979.1 - 2e-68 231.3 0.0 2.6e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase ABC_tran PF00005.27 KPI83980.1 - 8.6e-11 42.5 0.0 0.00031 21.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_22 PF13401.6 KPI83980.1 - 0.0011 19.2 0.0 0.0031 17.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI83980.1 - 0.02 15.3 0.1 0.24 11.8 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 KPI83980.1 - 0.09 12.5 1.6 0.12 12.2 0.3 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 KPI83980.1 - 0.11 12.8 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 KPI83980.1 - 0.17 11.8 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 KPI83980.1 - 0.19 11.5 0.1 0.58 9.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Senescence_reg PF04520.13 KPI83982.1 - 3.6 8.4 8.0 1.4 9.7 1.1 2.8 2 0 0 2 2 2 0 Senescence regulator TSP9 PF11493.8 KPI83983.1 - 1.8 9.3 7.2 1.5 9.6 2.6 2.4 2 0 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 DUF4810 PF16068.5 KPI83984.1 - 0.042 14.4 0.0 0.066 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) C2 PF00168.30 KPI83985.1 - 2e-22 79.4 0.0 3.4e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain DOCK-C2 PF14429.6 KPI83985.1 - 0.1 12.4 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 C2 domain in Dock180 and Zizimin proteins C2 PF00168.30 KPI83986.1 - 2.9e-17 62.8 0.0 4.3e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain PAT1 PF09770.9 KPI83986.1 - 1.5 7.0 5.9 1.9 6.7 5.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 KPI83986.1 - 1.8 8.5 13.3 2.2 8.2 13.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CHD5 PF04420.14 KPI83987.1 - 0.0088 15.9 2.0 0.026 14.4 2.0 1.8 1 0 0 1 1 1 1 CHD5-like protein BAR_3 PF16746.5 KPI83987.1 - 0.019 14.7 7.1 0.012 15.4 5.4 1.5 1 1 0 1 1 1 0 BAR domain of APPL family DUF812 PF05667.11 KPI83987.1 - 0.21 10.4 6.9 0.23 10.3 2.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) MAT1 PF06391.13 KPI83988.1 - 0.11 12.3 1.3 0.17 11.7 1.3 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF4404 PF14357.6 KPI83989.1 - 0.038 14.6 2.1 0.089 13.4 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Laminin_II PF06009.12 KPI83989.1 - 0.077 13.0 6.5 0.11 12.5 3.5 2.2 1 1 1 2 2 2 0 Laminin Domain II FbpA PF05833.11 KPI83990.1 - 0.012 14.4 0.9 0.015 14.1 0.9 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF573 PF04504.14 KPI83990.1 - 0.058 14.1 0.6 0.12 13.0 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF573 FapA PF03961.13 KPI83990.1 - 0.074 11.6 0.2 0.087 11.4 0.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A KxDL PF10241.9 KPI83990.1 - 0.22 11.9 9.1 4.4 7.6 0.1 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein MCU PF04678.13 KPI83990.1 - 0.28 11.3 6.4 0.25 11.4 5.2 1.6 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF4407 PF14362.6 KPI83990.1 - 0.5 9.7 5.9 0.29 10.5 2.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Siah-Interact_N PF09032.11 KPI83990.1 - 0.58 10.5 6.6 4 7.8 0.6 3.0 2 1 1 3 3 3 0 Siah interacting protein, N terminal BRE1 PF08647.11 KPI83990.1 - 0.76 9.9 7.3 1.6 8.8 5.1 2.1 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase XhlA PF10779.9 KPI83990.1 - 0.78 10.0 4.4 0.26 11.5 0.6 2.1 3 0 0 3 3 3 0 Haemolysin XhlA TMF_TATA_bd PF12325.8 KPI83990.1 - 0.86 9.8 11.7 2.2 8.5 7.4 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding FUSC PF04632.12 KPI83990.1 - 1.1 7.7 12.8 4.6 5.7 12.6 1.8 1 1 0 1 1 1 0 Fusaric acid resistance protein family Spc24 PF08286.11 KPI83990.1 - 1.5 9.1 5.5 0.6 10.4 1.5 2.3 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 DUF1664 PF07889.12 KPI83990.1 - 1.6 8.8 5.2 3.4 7.7 2.6 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3322 PF11795.8 KPI83991.1 - 0.031 14.3 0.5 0.058 13.4 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) DUF1330 PF07045.11 KPI83991.1 - 0.073 13.4 0.1 0.22 11.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) DUF1841 PF08897.11 KPI83991.1 - 0.16 12.0 0.7 7.6 6.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1841) Lact-deh-memb PF09330.11 KPI83991.1 - 0.16 11.3 0.5 0.28 10.5 0.2 1.4 1 1 0 1 1 1 0 D-lactate dehydrogenase, membrane binding PmbA_TldD PF01523.16 KPI83993.1 - 0.15 11.9 4.0 0.19 11.5 2.9 1.6 1 1 0 1 1 1 0 Putative modulator of DNA gyrase CesT PF05932.13 KPI83994.1 - 1.9e-15 57.0 0.4 8.7e-15 54.9 0.0 2.2 3 0 0 3 3 3 1 Tir chaperone protein (CesT) family DUF4686 PF15742.5 KPI83994.1 - 0.00036 19.8 1.2 0.00048 19.4 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) Spc7 PF08317.11 KPI83994.1 - 0.0061 15.5 0.5 0.0088 15.0 0.5 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Cep57_CLD PF14073.6 KPI83994.1 - 0.013 15.5 1.4 0.019 15.0 1.4 1.2 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 ATG16 PF08614.11 KPI83994.1 - 0.057 13.6 6.4 0.085 13.1 6.4 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 KPI83994.1 - 0.23 11.2 1.4 0.45 10.3 1.4 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.6 KPI83994.1 - 0.34 11.4 4.2 0.17 12.4 1.9 1.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Abhydrolase_1 PF00561.20 KPI83996.1 - 3.6e-16 59.6 0.0 1.5e-15 57.6 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KPI83996.1 - 1e-08 36.0 0.0 3.2e-08 34.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KPI83996.1 - 6.3e-07 28.9 0.1 0.033 13.5 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 KPI83996.1 - 1.2e-05 25.4 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Esterase PF00756.20 KPI83996.1 - 1.3e-05 25.0 0.0 1.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 KPI83996.1 - 0.00016 21.2 0.2 0.55 9.7 0.0 2.4 2 0 0 2 2 2 2 Esterase PHB depolymerase Thioesterase PF00975.20 KPI83996.1 - 0.0017 18.5 0.1 0.0035 17.5 0.1 1.5 1 0 0 1 1 1 1 Thioesterase domain DUF2048 PF09752.9 KPI83996.1 - 0.003 16.7 0.0 0.0068 15.5 0.0 1.5 2 0 0 2 2 2 1 Abhydrolase domain containing 18 Ndr PF03096.14 KPI83996.1 - 0.009 14.7 0.0 0.016 13.9 0.0 1.3 1 0 0 1 1 1 1 Ndr family FSH1 PF03959.13 KPI83996.1 - 0.022 14.5 0.0 0.85 9.2 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Ser_hydrolase PF06821.13 KPI83996.1 - 0.025 14.4 0.1 0.073 12.9 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase PGAP1 PF07819.13 KPI83996.1 - 0.05 13.3 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.20 KPI83997.1 - 8.4e-18 64.9 0.0 2.2e-17 63.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI83997.1 - 2.9e-12 46.4 0.0 1.3e-11 44.3 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI83997.1 - 2.6e-10 41.3 1.8 4e-10 40.7 1.8 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 KPI83997.1 - 3.8e-06 26.6 0.5 0.0033 16.9 0.0 2.3 2 0 0 2 2 2 2 Esterase PHB depolymerase Esterase PF00756.20 KPI83997.1 - 2e-05 24.4 0.0 3.6e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Putative esterase DLH PF01738.18 KPI83997.1 - 6.5e-05 22.6 0.0 0.0095 15.5 0.0 2.3 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_4 PF08386.10 KPI83997.1 - 9.6e-05 22.4 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_2 PF02230.16 KPI83997.1 - 0.00052 19.9 0.0 0.0051 16.6 0.0 2.0 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KPI83997.1 - 0.00069 19.1 0.2 0.088 12.3 0.0 2.6 3 0 0 3 3 3 1 Prolyl oligopeptidase family Ndr PF03096.14 KPI83997.1 - 0.011 14.4 0.0 0.02 13.6 0.0 1.3 1 0 0 1 1 1 0 Ndr family DUF2048 PF09752.9 KPI83997.1 - 0.026 13.6 0.4 0.043 12.9 0.4 1.3 1 0 0 1 1 1 0 Abhydrolase domain containing 18 FSH1 PF03959.13 KPI83997.1 - 0.04 13.6 0.0 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Thioesterase PF00975.20 KPI83997.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Ser_hydrolase PF06821.13 KPI83997.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase HA PF03457.14 KPI83997.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Helicase associated domain PGAP1 PF07819.13 KPI83997.1 - 0.19 11.4 0.1 0.4 10.4 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.20 KPI83998.1 - 1.2e-14 54.6 0.0 3.8e-14 52.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI83998.1 - 4.6e-11 42.4 1.2 1.2e-10 41.0 0.1 2.1 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI83998.1 - 1.9e-07 31.9 2.4 1.9e-07 31.9 2.4 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 KPI83998.1 - 0.0099 16.0 0.0 0.035 14.2 0.0 1.9 1 0 0 1 1 1 1 TAP-like protein Thioesterase PF00975.20 KPI83998.1 - 0.05 13.7 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain PLAC8 PF04749.17 KPI83999.1 - 0.36 11.9 17.2 2 9.5 17.2 2.3 1 1 0 1 1 1 0 PLAC8 family UCH PF00443.29 KPI84001.1 - 3.3e-19 69.4 0.0 1.5e-18 67.2 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI84001.1 - 2.4e-07 30.7 0.0 4.6e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rubredoxin_2 PF18073.1 KPI84001.1 - 0.18 11.5 3.2 0.45 10.3 3.2 1.7 1 0 0 1 1 1 0 Rubredoxin metal binding domain SET PF00856.28 KPI84002.1 - 8.9e-05 22.9 0.0 0.00019 21.9 0.0 1.6 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 KPI84002.1 - 0.00038 20.5 5.7 0.00038 20.5 5.7 2.4 2 0 0 2 2 2 1 MYND finger Zn-ribbon_8 PF09723.10 KPI84002.1 - 0.083 13.0 0.5 0.28 11.3 0.5 1.9 1 0 0 1 1 1 0 Zinc ribbon domain TPR_2 PF07719.17 KPI84002.1 - 0.14 12.4 0.0 2.7 8.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat HEAT_2 PF13646.6 KPI84003.1 - 3e-05 24.3 15.4 0.1 13.0 2.3 5.7 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 KPI84003.1 - 0.026 14.7 0.0 0.026 14.7 0.0 5.9 7 0 0 7 7 7 0 HEAT repeat DUF4310 PF14187.6 KPI84003.1 - 0.17 11.5 0.6 0.33 10.6 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4310) PIF1 PF05970.14 KPI84004.1 - 5.3e-28 98.2 0.1 1.2e-24 87.2 0.0 2.6 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 KPI84004.1 - 6.9e-17 61.8 0.0 1.7e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KPI84004.1 - 9.3e-07 29.3 0.1 2.8e-06 27.7 0.1 1.8 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KPI84004.1 - 0.00015 21.6 0.0 0.00042 20.1 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 KPI84004.1 - 0.00017 22.0 0.6 0.011 16.1 0.0 3.1 3 0 0 3 3 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 KPI84004.1 - 0.00024 20.9 0.1 0.82 9.4 0.0 2.8 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 KPI84004.1 - 0.00068 19.0 0.1 0.0057 15.9 0.1 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 KPI84004.1 - 0.014 14.5 0.0 0.03 13.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 KPI84004.1 - 0.014 15.8 0.0 0.052 14.0 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_32 PF13654.6 KPI84004.1 - 0.04 12.7 0.2 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 KPI84004.1 - 0.044 13.7 0.3 0.093 12.6 0.3 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.17 KPI84004.1 - 0.077 12.7 0.3 0.27 10.9 0.3 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.22 KPI84004.1 - 0.088 12.0 0.1 0.16 11.1 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain Bac_DnaA PF00308.18 KPI84004.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_7 PF12775.7 KPI84004.1 - 0.11 12.0 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF853 PF05872.12 KPI84004.1 - 0.11 11.0 0.1 0.21 10.1 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Mg_chelatase PF01078.21 KPI84004.1 - 0.14 11.5 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI UvrD-helicase PF00580.21 KPI84004.1 - 0.15 11.6 0.1 0.49 9.8 0.0 1.8 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain MeaB PF03308.16 KPI84004.1 - 0.16 10.9 0.4 0.33 9.9 0.4 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DEAD PF00270.29 KPI84004.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Sigma54_activat PF00158.26 KPI84004.1 - 0.17 11.6 0.1 0.42 10.3 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Herpes_Helicase PF02689.14 KPI84004.1 - 0.17 9.8 0.1 8.1 4.2 0.0 2.2 2 0 0 2 2 2 0 Helicase NTPase_1 PF03266.15 KPI84004.1 - 0.18 11.7 1.2 0.38 10.7 0.4 2.0 2 0 0 2 2 2 0 NTPase DUF815 PF05673.13 KPI84004.1 - 0.42 9.7 2.1 0.51 9.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 KPI84004.1 - 0.46 10.7 3.7 3.6 7.9 0.8 3.5 3 1 0 3 3 3 0 AAA domain CbiA PF01656.23 KPI84004.1 - 0.47 10.5 1.5 1.3 9.1 1.5 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain R3H PF01424.22 KPI84005.1 - 4.1e-09 36.3 0.6 9.1e-09 35.2 0.1 1.9 2 0 0 2 2 2 1 R3H domain ABC_trans_N PF14510.6 KPI84005.1 - 0.1 13.2 2.1 0.75 10.4 0.0 3.2 3 0 0 3 3 3 0 ABC-transporter N-terminal Acyl-CoA_dh_C PF12806.7 KPI84006.1 - 2.6e-23 82.5 0.4 5.7e-23 81.4 0.4 1.6 1 0 0 1 1 1 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_M PF02770.19 KPI84006.1 - 4.2e-19 68.5 0.0 8.9e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 KPI84006.1 - 1.2e-18 67.8 3.4 1.4e-17 64.3 3.4 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KPI84006.1 - 1.2e-12 48.5 0.0 3.3e-12 47.1 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 KPI84006.1 - 9.5e-05 22.7 0.1 0.00021 21.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain IF4E PF01652.18 KPI84007.1 - 1.8e-28 99.4 0.0 2.3e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PAM2 PF07145.15 KPI84007.1 - 0.0075 15.9 2.5 2.2 8.2 0.0 2.7 2 0 0 2 2 2 2 Ataxin-2 C-terminal region ThiS PF02597.20 KPI84009.1 - 0.0073 16.9 0.1 0.018 15.7 0.0 1.6 2 0 0 2 2 2 1 ThiS family Rax2 PF12768.7 KPI84009.1 - 0.083 12.3 0.0 0.083 12.3 0.0 1.5 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF4179 PF13786.6 KPI84009.1 - 1.7 9.2 4.1 3.5 8.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) ParA PF10609.9 KPI84010.1 - 3.6e-90 301.7 0.0 4.1e-90 301.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KPI84010.1 - 2.2e-15 56.8 0.0 3.3e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KPI84010.1 - 2e-12 47.4 1.3 5.9e-10 39.3 0.2 2.2 2 0 0 2 2 2 2 AAA domain MipZ PF09140.11 KPI84010.1 - 1.5e-08 34.3 1.4 7.2e-08 32.0 1.4 1.9 1 1 0 1 1 1 1 ATPase MipZ VirC1 PF07015.11 KPI84010.1 - 1.4e-05 24.5 0.1 3e-05 23.4 0.1 1.5 2 0 0 2 2 2 1 VirC1 protein Fer4_NifH PF00142.18 KPI84010.1 - 2.6e-05 23.8 0.0 9.4e-05 22.0 0.1 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 KPI84010.1 - 0.00015 21.1 0.4 0.00063 19.0 0.3 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 KPI84010.1 - 0.0038 16.7 0.1 0.0098 15.4 0.1 1.7 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ DUF1611 PF07755.11 KPI84010.1 - 0.023 14.0 0.5 0.073 12.3 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_C) P-loop domain MeaB PF03308.16 KPI84010.1 - 0.081 11.9 0.6 0.12 11.3 0.6 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Utp12 PF04003.12 KPI84011.1 - 0.054 13.8 0.1 1.4 9.3 0.1 2.4 2 0 0 2 2 2 0 Dip2/Utp12 Family Cupin_8 PF13621.6 KPI84012.1 - 3.3e-57 194.1 0.0 2.4e-56 191.3 0.0 2.0 1 1 0 1 1 1 1 Cupin-like domain DnaJ PF00226.31 KPI84014.1 - 8.8e-21 73.8 0.5 1.7e-20 72.9 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KPI84014.1 - 7.6e-10 38.6 0.4 0.0001 21.8 0.2 2.7 2 1 1 3 3 3 2 X-domain of DnaJ-containing GRAS PF03514.14 KPI84014.1 - 0.12 11.3 0.2 0.22 10.4 0.2 1.3 1 0 0 1 1 1 0 GRAS domain family Antimicrobial_6 PF08036.11 KPI84014.1 - 3.9 7.6 5.5 6.2 7.0 0.8 2.7 2 0 0 2 2 2 0 Diapausin family of antimicrobial peptide FYVE PF01363.21 KPI84015.1 - 2.4e-16 59.6 4.5 9.1e-16 57.8 2.3 2.7 2 0 0 2 2 2 1 FYVE zinc finger Mitofilin PF09731.9 KPI84018.1 - 0.093 11.5 5.9 0.14 11.0 5.9 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein UEV PF05743.13 KPI84019.1 - 8.3e-11 41.8 0.0 8.4e-10 38.6 0.0 2.1 2 0 0 2 2 2 1 UEV domain zf-C3HC4_3 PF13920.6 KPI84019.1 - 2.6e-09 36.8 11.8 2.6e-09 36.8 11.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI84019.1 - 0.0025 17.6 9.5 0.0025 17.6 9.5 2.3 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 UQ_con PF00179.26 KPI84019.1 - 0.057 13.1 0.1 0.09 12.4 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme PUB PF09409.10 KPI84020.1 - 2.1e-09 37.2 0.1 3.8e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 PUB domain VPS13 PF16908.5 KPI84021.1 - 0.066 13.0 0.7 0.18 11.6 0.7 1.8 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal PAM2 PF07145.15 KPI84022.1 - 0.23 11.2 10.9 12 5.8 0.1 4.9 5 0 0 5 5 5 0 Ataxin-2 C-terminal region MFS_1 PF07690.16 KPI84023.1 - 9.9e-17 60.9 44.3 2.4e-14 53.0 25.0 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 KPI84023.1 - 5e-09 36.0 19.9 5e-09 36.0 19.9 3.2 2 2 0 2 2 2 1 Nodulin-like LpqV PF17301.2 KPI84023.1 - 0.025 14.8 0.3 0.05 13.9 0.3 1.4 1 0 0 1 1 1 0 Putative lipoprotein LpqV Peptidase_M17 PF00883.21 KPI84025.1 - 4.6e-82 275.8 0.9 6.6e-82 275.3 0.9 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 KPI84025.1 - 2e-31 108.8 0.3 7.3e-31 107.0 0.3 2.1 1 0 0 1 1 1 1 M17 aminopeptidase N-terminal domain 2 Ribosomal_S11 PF00411.19 KPI84025.1 - 0.53 10.7 5.9 0.16 12.4 0.5 2.7 2 1 1 3 3 3 0 Ribosomal protein S11 C1_1 PF00130.22 KPI84027.1 - 0.15 11.9 0.2 0.15 11.9 0.2 3.2 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CCHC_4 PF14392.6 KPI84027.1 - 0.57 10.0 15.3 0.88 9.4 0.1 3.4 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.6 KPI84027.1 - 7.7 6.6 15.3 0.79 9.7 1.5 4.1 3 1 0 3 3 3 0 Zinc knuckle Carboxyl_trans PF01039.22 KPI84028.1 - 1.8e-137 459.0 0.1 2.3e-137 458.7 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KPI84028.1 - 0.0011 18.6 0.2 1.6 8.2 0.1 2.3 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) FliD_N PF02465.18 KPI84029.1 - 6.8 7.5 10.1 0.27 11.9 3.8 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Flagellar_rod PF05149.12 KPI84030.1 - 8e-80 268.4 25.1 8e-80 268.4 25.1 2.5 2 1 1 3 3 3 1 Paraflagellar rod protein Baculo_PEP_C PF04513.12 KPI84030.1 - 0.095 12.7 5.1 1 9.4 0.0 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus COPR5 PF15340.6 KPI84030.1 - 1.6 9.4 4.4 0.65 10.6 0.6 2.3 2 0 0 2 2 2 0 Cooperator of PRMT5 family DUF4011 PF13195.6 KPI84030.1 - 3.3 7.6 6.3 5 7.0 2.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4011) UQ_con PF00179.26 KPI84031.1 - 7.3e-11 41.9 0.0 1.3e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BRE PF06113.12 KPI84031.1 - 0.013 14.4 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) Peptidase_M28 PF04389.17 KPI84033.1 - 1e-13 51.5 1.1 0.0015 18.3 0.0 3.3 3 0 0 3 3 3 3 Peptidase family M28 Peptidase_M49 PF03571.15 KPI84034.1 - 4e-218 725.3 0.0 4.6e-218 725.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M49 DUF3626 PF12294.8 KPI84034.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3626) RVT_1 PF00078.27 KPI84035.1 - 7.8e-33 113.9 0.0 4.7e-32 111.3 0.0 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 KPI84035.1 - 2.2e-13 50.1 0.1 5.4e-13 48.8 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-C2H2_6 PF13912.6 KPI84035.1 - 0.002 18.1 0.1 0.0053 16.7 0.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger RNase_H PF00075.24 KPI84035.1 - 0.003 17.7 0.0 0.0098 16.1 0.0 1.9 1 1 0 1 1 1 1 RNase H zf-Di19 PF05605.12 KPI84035.1 - 0.0043 17.3 3.3 0.014 15.7 3.3 1.8 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Exo_endo_phos PF03372.23 KPI84035.1 - 0.0092 15.5 1.3 0.027 14.0 1.3 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C2H2_4 PF13894.6 KPI84035.1 - 0.041 14.7 14.9 0.065 14.1 0.6 4.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI84035.1 - 0.26 11.8 7.3 0.15 12.6 0.3 3.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type ABATE PF07336.11 KPI84035.1 - 0.37 11.5 4.2 2 9.1 4.2 2.3 1 0 0 1 1 1 0 Putative stress-induced transcription regulator Methyltransf_28 PF02636.17 KPI84036.1 - 7.3e-39 134.0 0.0 1.1e-38 133.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 KPI84036.1 - 0.0035 17.2 0.0 0.0056 16.5 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_25 PF13649.6 KPI84036.1 - 0.0071 17.0 0.0 0.019 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84036.1 - 0.0091 16.7 0.0 0.02 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 KPI84036.1 - 0.0097 15.0 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 KPI84036.1 - 0.041 13.7 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DHHC PF01529.20 KPI84037.1 - 1.6e-31 109.2 15.6 1.6e-31 109.2 15.6 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase polyprenyl_synt PF00348.17 KPI84038.1 - 8.3e-76 254.4 0.6 1e-75 254.1 0.6 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase E3_UbLigase_EDD PF11547.8 KPI84039.1 - 0.027 14.2 0.5 0.084 12.6 0.5 1.9 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD Ribosomal_L28e PF01778.17 KPI84040.1 - 6.1e-29 101.1 0.0 1.4e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 KPI84040.1 - 1.1e-15 58.1 21.4 1.1e-15 58.1 21.4 2.2 1 1 1 2 2 2 1 Mak16 protein C-terminal region CDC45 PF02724.14 KPI84040.1 - 1.2 7.4 14.6 0.55 8.5 12.7 1.3 1 1 0 1 1 1 0 CDC45-like protein TPR_19 PF14559.6 KPI84041.1 - 0.012 16.1 0.1 0.043 14.3 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat MORN PF02493.20 KPI84042.1 - 3.6e-46 152.4 79.4 5.4e-05 22.9 0.1 12.9 13 0 0 13 13 13 12 MORN repeat Cytochrome_CBB3 PF13442.6 KPI84042.1 - 5.4 7.4 6.0 7.6 6.9 0.8 2.8 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III EF-hand_1 PF00036.32 KPI84043.1 - 2.6e-29 98.5 8.7 2.8e-08 32.7 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KPI84043.1 - 1.3e-26 92.8 1.7 5.2e-13 49.2 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI84043.1 - 6.7e-22 75.5 3.9 6e-07 28.9 0.0 4.4 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KPI84043.1 - 1.2e-19 69.9 7.6 7.1e-10 38.6 0.4 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KPI84043.1 - 1.1e-17 62.7 8.2 1.7e-05 24.1 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KPI84043.1 - 5.3e-08 33.1 0.1 1.3e-06 28.6 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 KPI84043.1 - 2.6e-07 30.5 3.2 0.024 14.6 0.7 3.3 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 KPI84043.1 - 0.024 14.7 0.1 7.4 6.7 0.0 2.7 2 1 0 2 2 2 0 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.9 KPI84043.1 - 0.039 14.3 0.1 0.14 12.5 0.1 1.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3911 PF13050.6 KPI84043.1 - 0.075 13.2 0.2 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3911) Dockerin_1 PF00404.18 KPI84043.1 - 0.45 10.7 2.1 9.9 6.4 1.9 2.7 1 1 1 2 2 2 0 Dockerin type I domain MIP PF00230.20 KPI84044.1 - 1.4e-23 83.8 17.2 9.2e-23 81.1 17.2 1.9 1 1 0 1 1 1 1 Major intrinsic protein CPP1-like PF11833.8 KPI84044.1 - 0.047 13.3 5.0 0.73 9.5 0.7 3.0 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3792 PF12670.7 KPI84044.1 - 2.6 8.3 18.1 1.3 9.2 4.8 3.2 2 2 0 2 2 2 0 Protein of unknown function (DUF3792) FKBP_C PF00254.28 KPI84045.1 - 7.5e-30 103.1 0.0 8.7e-30 102.9 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase AA_permease_2 PF13520.6 KPI84047.1 - 6.5e-33 114.2 42.4 8.6e-33 113.8 42.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KPI84047.1 - 1.6e-12 46.8 38.6 3.7e-12 45.6 38.6 1.5 1 1 0 1 1 1 1 Amino acid permease Proteasome PF00227.26 KPI84048.1 - 1.8e-48 164.5 0.0 2.4e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI84048.1 - 3.8e-13 48.8 0.3 7.3e-13 47.9 0.3 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Epimerase PF01370.21 KPI84050.1 - 5.3e-08 32.6 0.2 0.00043 19.8 0.0 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KPI84050.1 - 5.8e-05 22.4 0.0 0.044 13.0 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 KPI84050.1 - 0.00079 19.4 0.1 0.19 11.6 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding RmlD_sub_bind PF04321.17 KPI84050.1 - 0.0022 17.2 0.0 1.5 7.8 0.0 2.6 2 0 0 2 2 2 2 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KPI84050.1 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KPI84050.1 - 0.16 11.0 0.2 15 4.4 0.2 2.3 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Rubredoxin_2 PF18073.1 KPI84051.1 - 5.2 6.9 7.2 4.7 7.0 2.1 2.7 2 0 0 2 2 2 0 Rubredoxin metal binding domain Na_Ca_ex PF01699.24 KPI84052.1 - 2e-07 31.1 42.3 0.00066 19.7 22.7 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein HEAT PF02985.22 KPI84053.1 - 4.4e-19 66.9 19.8 0.012 15.8 0.0 10.5 11 1 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.6 KPI84053.1 - 8.5e-14 51.7 15.7 1.4e-05 25.4 0.0 7.0 4 3 2 7 7 7 5 HEAT repeats Cnd1 PF12717.7 KPI84053.1 - 3.4e-05 23.9 0.1 2.9 7.9 0.0 4.3 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KPI84053.1 - 0.00021 20.0 2.1 0.52 8.8 0.0 4.0 2 2 2 4 4 4 2 Adaptin N terminal region HEAT_EZ PF13513.6 KPI84053.1 - 0.0003 21.2 5.0 0.025 15.1 0.0 5.1 5 0 0 5 5 5 1 HEAT-like repeat CLASP_N PF12348.8 KPI84053.1 - 0.0064 16.1 0.1 10 5.6 0.0 3.9 2 2 2 4 4 4 1 CLASP N terminal Wap1 PF16997.5 KPI84053.1 - 0.11 11.6 0.0 0.38 9.9 0.0 1.8 2 0 0 2 2 2 0 Wap1 domain NUC173 PF08161.12 KPI84053.1 - 0.19 11.3 1.3 6.2 6.4 0.1 3.6 3 1 1 4 4 4 0 NUC173 domain DUF1804 PF08822.11 KPI84053.1 - 5.3 7.0 7.7 8.6 6.3 0.2 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1804) PA26 PF04636.13 KPI84054.1 - 2.2e-33 115.9 0.6 5.1e-11 42.2 0.0 3.1 3 0 0 3 3 3 3 PA26 p53-induced protein (sestrin) Pkinase PF00069.25 KPI84055.1 - 2.3e-75 253.4 0.0 2.6e-75 253.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84055.1 - 1.4e-39 135.9 0.0 1.7e-39 135.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI84055.1 - 6.1e-10 38.9 0.0 1e-09 38.1 0.0 1.5 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KPI84055.1 - 5.4e-07 28.9 0.0 1.5e-06 27.4 0.1 1.6 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 KPI84055.1 - 1.7e-05 24.9 0.1 0.11 12.4 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KPI84055.1 - 0.015 14.7 0.1 0.026 13.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF421 PF04239.12 KPI84055.1 - 0.095 12.5 0.9 0.22 11.3 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF421) Phosducin PF02114.16 KPI84055.1 - 0.099 11.6 0.1 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Phosducin 2OG-FeII_Oxy PF03171.20 KPI84057.1 - 1e-14 54.8 0.0 2.1e-14 53.8 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KPI84057.1 - 0.035 15.0 0.0 0.061 14.2 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KPI84057.1 - 0.047 14.4 0.0 0.94 10.3 0.0 2.4 2 0 0 2 2 2 0 non-haem dioxygenase in morphine synthesis N-terminal SecE PF00584.20 KPI84058.1 - 3.9e-14 52.3 0.1 4.8e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex NAD_binding_2 PF03446.15 KPI84059.1 - 5.5e-31 107.9 0.0 9.3e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KPI84059.1 - 1.3e-12 48.0 2.9 1.3e-12 48.0 0.5 2.2 2 1 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 KPI84059.1 - 0.00014 21.9 1.0 0.0053 16.8 0.1 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 KPI84059.1 - 0.0084 16.7 0.2 0.051 14.2 0.0 2.3 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 KPI84059.1 - 0.015 16.2 0.0 1.2 9.9 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Phage_GP20 PF06810.11 KPI84062.1 - 1.5 8.6 4.9 0.77 9.6 0.6 2.4 3 0 0 3 3 3 0 Phage minor structural protein GP20 YabA PF06156.13 KPI84062.1 - 2.7 8.7 8.7 0.15 12.7 0.9 2.8 3 1 0 3 3 3 0 Initiation control protein YabA ZapB PF06005.12 KPI84062.1 - 4.9 7.7 17.5 0.076 13.5 0.5 3.2 3 0 0 3 3 3 0 Cell division protein ZapB Frataxin_Cyay PF01491.16 KPI84063.1 - 6.8e-30 103.3 0.2 8.7e-30 103.0 0.2 1.1 1 0 0 1 1 1 1 Frataxin-like domain HTH_6 PF01418.17 KPI84063.1 - 0.054 13.5 0.1 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family RRM_1 PF00076.22 KPI84066.1 - 3.7e-05 23.5 0.0 6.5e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 KPI84067.1 - 3.1e-12 45.6 92.6 2.4e-07 29.9 1.0 9.5 9 1 0 9 9 9 6 Zn-finger in Ran binding protein and others DZR PF12773.7 KPI84067.1 - 2.3e-07 30.7 74.4 0.059 13.4 11.5 6.6 4 3 2 6 6 6 6 Double zinc ribbon zf-RanBP PF00641.18 KPI84068.1 - 0.0082 15.4 0.6 0.0082 15.4 0.6 15.2 15 1 0 15 15 15 9 Zn-finger in Ran binding protein and others DZR PF12773.7 KPI84068.1 - 0.0094 16.0 127.9 0.015 15.3 5.9 10.0 3 3 4 8 8 8 4 Double zinc ribbon ARL2_Bind_BART PF11527.8 KPI84069.1 - 1.3e-29 102.6 0.2 2.2e-29 101.9 0.2 1.4 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART UIM PF02809.20 KPI84069.1 - 0.084 12.8 2.1 0.24 11.4 2.1 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Amastin PF07344.11 KPI84070.1 - 1.2e-26 93.5 4.8 1.5e-26 93.1 4.8 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein Claudin_3 PF06653.11 KPI84070.1 - 0.0041 17.1 6.4 0.76 9.7 2.0 2.6 3 1 0 3 3 3 2 Tight junction protein, Claudin-like EVI2A PF05399.11 KPI84070.1 - 0.043 13.4 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF5305 PF17231.2 KPI84070.1 - 0.085 12.2 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF898 PF05987.13 KPI84070.1 - 0.89 8.5 6.3 0.2 10.7 0.7 2.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF898) DUF3810 PF12725.7 KPI84070.1 - 1.4 8.2 4.5 0.58 9.5 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Chordopox_A13L PF05961.11 KPI84070.1 - 2.3 8.5 0.0 2.3 8.5 0.0 3.4 4 0 0 4 4 4 0 Chordopoxvirus A13L protein HalOD2 PF18547.1 KPI84071.1 - 0.016 15.1 2.6 0.018 15.0 0.4 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 zf-ISL3 PF14690.6 KPI84071.1 - 0.046 14.4 0.1 0.12 13.1 0.1 1.7 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-4CXXC_R1 PF10497.9 KPI84071.1 - 0.32 11.2 5.2 2.3 8.5 5.2 2.0 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-HIT PF04438.16 KPI84071.1 - 0.73 9.8 4.9 6.8 6.7 0.7 2.6 2 0 0 2 2 2 0 HIT zinc finger DUF4407 PF14362.6 KPI84072.1 - 0.0058 16.0 4.5 0.012 15.0 4.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF4964 PF16334.5 KPI84072.1 - 0.055 13.0 0.0 5.4 6.6 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4964) T2SSM_b PF10741.9 KPI84072.1 - 0.097 12.5 0.6 0.51 10.2 0.3 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M subtype b RRP36 PF06102.12 KPI84072.1 - 1.9 8.4 7.8 0.33 10.9 1.0 2.5 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 Sigma70_ner PF04546.13 KPI84072.1 - 3.5 7.5 6.6 0.64 9.9 2.4 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Trypsin_2 PF13365.6 KPI84073.1 - 2.1e-05 25.5 0.1 9.3e-05 23.4 0.1 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain Aa_trans PF01490.18 KPI84074.1 - 4.2e-06 25.7 0.6 5.8e-06 25.3 0.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI84074.1 - 0.053 12.5 0.2 0.065 12.3 0.2 1.1 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family Aa_trans PF01490.18 KPI84075.1 - 4.7e-23 81.5 14.7 6.9e-23 81.0 14.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Tenui_PVC2 PF06656.11 KPI84075.1 - 0.023 12.7 0.8 0.031 12.2 0.8 1.1 1 0 0 1 1 1 0 Tenuivirus PVC2 protein ThrE PF06738.12 KPI84075.1 - 3.4 7.0 17.0 5.6 6.3 9.0 2.3 2 0 0 2 2 2 0 Putative threonine/serine exporter AAA PF00004.29 KPI84076.1 - 2e-95 316.3 0.0 8.5e-47 158.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI84076.1 - 6e-27 93.2 9.1 3.7e-13 49.0 0.3 3.2 3 1 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 KPI84076.1 - 6.4e-22 77.5 0.5 2.6e-21 75.6 0.1 2.4 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 KPI84076.1 - 1.2e-13 51.1 0.0 1.1e-05 25.3 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI84076.1 - 1.6e-12 48.1 0.2 0.0003 21.2 0.0 4.0 2 2 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 KPI84076.1 - 4.4e-12 46.4 0.0 1.8e-06 28.2 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KPI84076.1 - 8.3e-11 42.2 0.0 2.5e-05 24.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 KPI84076.1 - 2.3e-10 40.6 0.2 5.8e-05 23.1 0.0 3.4 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 KPI84076.1 - 2.1e-09 37.0 0.0 5e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 KPI84076.1 - 2.2e-09 37.7 0.3 0.04 14.2 0.0 4.1 2 2 2 4 4 4 2 AAA domain TIP49 PF06068.13 KPI84076.1 - 1.1e-08 34.7 0.0 0.00037 19.8 0.1 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 KPI84076.1 - 1.1e-07 32.4 0.0 0.016 15.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 KPI84076.1 - 1.2e-07 31.9 0.0 0.0046 17.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KPI84076.1 - 2.3e-07 31.2 0.0 0.005 17.2 0.0 2.9 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 KPI84076.1 - 4.5e-07 29.5 0.2 0.032 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KPI84076.1 - 4.5e-06 26.5 0.0 0.074 12.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Vps4_C PF09336.10 KPI84076.1 - 4.8e-06 26.5 0.2 0.00051 20.0 0.0 3.1 2 1 0 2 2 2 1 Vps4 C terminal oligomerisation domain ABC_tran PF00005.27 KPI84076.1 - 8.8e-06 26.3 0.0 0.036 14.6 0.0 3.1 2 1 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 KPI84076.1 - 1.5e-05 25.4 0.0 0.11 12.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 KPI84076.1 - 1.7e-05 24.5 0.4 1.3 8.5 0.0 3.5 2 1 1 3 3 3 1 AAA domain AAA_28 PF13521.6 KPI84076.1 - 1.8e-05 25.1 0.1 0.26 11.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 KPI84076.1 - 2.1e-05 23.9 0.0 0.12 11.6 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin ATPase PF06745.13 KPI84076.1 - 3e-05 23.5 0.1 1.5 8.1 0.0 3.5 3 0 0 3 3 3 1 KaiC ATPase_2 PF01637.18 KPI84076.1 - 3.4e-05 23.9 0.2 0.31 10.9 0.0 2.9 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 KPI84076.1 - 3.6e-05 23.0 0.0 0.057 12.5 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 KPI84076.1 - 6.1e-05 22.8 0.0 0.11 12.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 KPI84076.1 - 6.8e-05 22.9 0.1 0.17 11.8 0.0 3.0 3 0 0 3 3 3 1 NACHT domain Viral_helicase1 PF01443.18 KPI84076.1 - 0.0001 22.2 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 KPI84076.1 - 0.00011 22.0 0.0 0.61 9.8 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 KPI84076.1 - 0.00011 22.1 0.0 0.68 9.9 0.0 2.7 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 KPI84076.1 - 0.00013 21.9 0.0 0.14 11.9 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_7 PF12775.7 KPI84076.1 - 0.00018 21.1 0.0 0.54 9.7 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_3 PF07726.11 KPI84076.1 - 0.00027 20.8 0.0 0.84 9.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 KPI84076.1 - 0.00072 19.6 0.0 0.063 13.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit NB-ARC PF00931.22 KPI84076.1 - 0.00085 18.6 0.0 1.1 8.4 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activ_2 PF14532.6 KPI84076.1 - 0.0016 18.6 0.0 0.81 9.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain PhoH PF02562.16 KPI84076.1 - 0.0025 17.3 0.1 1.4 8.3 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein DUF2075 PF09848.9 KPI84076.1 - 0.0031 16.8 0.0 0.88 8.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Molydop_binding PF01568.21 KPI84076.1 - 0.0048 16.9 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain NTPase_1 PF03266.15 KPI84076.1 - 0.0084 16.0 1.2 10 6.0 0.0 4.0 3 1 1 4 4 4 0 NTPase Rad17 PF03215.15 KPI84076.1 - 0.011 15.7 0.0 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain Cytidylate_kin2 PF13189.6 KPI84076.1 - 0.02 15.0 0.6 1.4 9.0 0.0 2.8 3 0 0 3 3 2 0 Cytidylate kinase-like family AAA_19 PF13245.6 KPI84076.1 - 0.023 15.1 1.6 9.7 6.5 0.1 3.4 3 1 0 4 4 2 0 AAA domain DUF815 PF05673.13 KPI84076.1 - 0.027 13.7 0.0 6.1 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Cytidylate_kin PF02224.18 KPI84076.1 - 0.033 13.9 0.0 5.5 6.7 0.0 2.7 3 0 0 3 3 2 0 Cytidylate kinase AAA_11 PF13086.6 KPI84076.1 - 0.036 13.9 0.0 12 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 KPI84076.1 - 0.045 13.5 0.1 7.9 6.2 0.0 3.6 4 0 0 4 4 4 0 DEAD/DEAH box helicase AAA_29 PF13555.6 KPI84076.1 - 0.052 13.3 0.0 7.4 6.4 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TEX19 PF15553.6 KPI84076.1 - 0.062 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 SKI PF01202.22 KPI84076.1 - 0.066 13.3 0.1 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase AAA_23 PF13476.6 KPI84076.1 - 0.075 13.5 0.2 22 5.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain Zot PF05707.12 KPI84076.1 - 0.084 12.5 0.0 1.1 8.8 0.0 2.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) KAP_NTPase PF07693.14 KPI84076.1 - 0.095 11.9 0.2 3.4 6.8 0.0 3.0 2 2 2 4 4 4 0 KAP family P-loop domain AAA_30 PF13604.6 KPI84076.1 - 0.1 12.3 0.1 9.6 5.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 KPI84076.1 - 0.11 12.3 0.0 3.7 7.3 0.0 2.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AFG1_ATPase PF03969.16 KPI84076.1 - 0.41 9.5 1.5 19 4.0 0.0 2.7 3 0 0 3 3 3 0 AFG1-like ATPase ADK PF00406.22 KPI84077.1 - 2.8e-42 144.4 0.0 3.7e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KPI84077.1 - 6.8e-25 88.1 0.1 1.8e-24 86.7 0.0 1.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI84077.1 - 1.4e-09 38.6 0.2 2e-08 34.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI84077.1 - 5.5e-06 26.6 0.1 1.9e-05 24.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 KPI84077.1 - 0.011 16.0 0.4 0.097 12.9 0.0 2.5 2 1 1 3 3 3 0 Hydin Adenylate kinase-like domain dNK PF01712.19 KPI84077.1 - 0.021 14.7 0.3 18 5.1 0.0 3.0 3 0 0 3 3 3 0 Deoxynucleoside kinase AAA_22 PF13401.6 KPI84077.1 - 0.021 15.1 0.0 0.076 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KPI84077.1 - 0.022 14.0 0.0 0.075 12.3 0.0 1.9 3 0 0 3 3 3 0 Zeta toxin KTI12 PF08433.10 KPI84077.1 - 0.027 13.9 0.3 0.099 12.1 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_28 PF13521.6 KPI84077.1 - 0.047 13.9 0.1 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 KPI84077.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase LRR_4 PF12799.7 KPI84079.1 - 7.3e-18 64.4 0.5 0.00073 19.9 0.5 8.7 6 2 4 10 10 10 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI84079.1 - 0.16 12.6 9.6 40 5.3 0.1 6.5 7 1 0 7 7 7 0 Leucine Rich Repeat ECH_1 PF00378.20 KPI84080.1 - 1.7e-36 125.8 0.0 2.3e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI84080.1 - 6.4e-10 39.0 0.0 8.6e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CLP_protease PF00574.23 KPI84080.1 - 0.053 13.4 0.1 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 Clp protease SPT16 PF08644.11 KPI84082.1 - 1.4e-29 103.2 2.0 1.7e-29 102.9 0.0 2.1 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 KPI84082.1 - 2.8e-15 56.6 0.0 5.5e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 KPI84082.1 - 9.6e-11 42.0 0.2 1.2e-09 38.5 0.0 2.5 2 0 0 2 2 2 1 Histone chaperone Rttp106-like fn3_5 PF06280.12 KPI84082.1 - 0.045 14.4 0.2 0.17 12.6 0.2 2.0 1 0 0 1 1 1 0 Fn3-like domain SAPS PF04499.15 KPI84082.1 - 0.47 9.2 3.3 0.89 8.3 2.4 1.8 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF3823_C PF18003.1 KPI84082.1 - 0.69 10.7 3.0 0.6 10.9 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3823_C) Nop14 PF04147.12 KPI84082.1 - 3.7 5.7 20.7 7.5 4.6 20.7 1.4 1 0 0 1 1 1 0 Nop14-like family Ribosomal_L3 PF00297.22 KPI84083.1 - 1.5e-08 34.0 0.1 2.7e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L3 BAR PF03114.18 KPI84084.1 - 0.013 15.1 0.2 0.081 12.6 0.0 1.9 2 0 0 2 2 2 0 BAR domain tRNA-synt_1b PF00579.25 KPI84086.1 - 3.1e-16 59.6 0.0 2.7e-15 56.5 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) SNARE PF05739.19 KPI84087.1 - 3.2e-06 27.0 8.2 1.6e-05 24.8 8.2 2.3 1 1 0 1 1 1 1 SNARE domain Prominin PF05478.11 KPI84087.1 - 0.00045 18.3 7.4 0.0016 16.5 0.6 2.0 2 0 0 2 2 2 2 Prominin Syntaxin PF00804.25 KPI84087.1 - 0.00061 19.5 0.4 0.00061 19.5 0.4 3.0 3 1 0 3 3 3 1 Syntaxin Syntaxin_2 PF14523.6 KPI84087.1 - 0.0012 19.1 4.9 0.0012 19.1 4.9 2.4 2 0 0 2 2 2 1 Syntaxin-like protein LXG PF04740.12 KPI84087.1 - 0.0079 15.9 1.5 0.0079 15.9 1.5 2.3 2 1 0 2 2 2 1 LXG domain of WXG superfamily LMBR1 PF04791.16 KPI84087.1 - 0.013 14.5 2.4 0.017 14.0 2.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein BLOC1S3 PF15753.5 KPI84087.1 - 0.035 14.2 7.8 0.062 13.4 0.5 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 MCPsignal PF00015.21 KPI84087.1 - 0.045 13.6 6.5 0.23 11.2 0.1 2.8 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 KPI84087.1 - 0.15 12.1 7.9 0.81 9.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Synaptobrevin PF00957.21 KPI84087.1 - 0.85 9.5 7.3 0.055 13.3 0.8 2.3 2 1 1 3 3 3 0 Synaptobrevin DUF948 PF06103.11 KPI84087.1 - 1 9.7 7.5 5.9 7.2 0.1 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.11 KPI84087.1 - 1.8 8.6 10.1 1.2 9.2 0.8 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RmuC PF02646.16 KPI84087.1 - 2.4 7.2 12.1 0.064 12.4 1.3 2.6 2 1 1 3 3 3 0 RmuC family Spc7 PF08317.11 KPI84087.1 - 5.2 5.9 16.4 1.1 8.1 7.1 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein T3SSipB PF16535.5 KPI84087.1 - 9.4 6.7 9.1 1 9.8 0.6 2.6 2 1 0 2 2 2 0 Type III cell invasion protein SipB Ras PF00071.22 KPI84089.1 - 3.5e-35 121.0 0.1 4e-35 120.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI84089.1 - 1.2e-19 70.7 0.0 1.7e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI84089.1 - 7.2e-14 51.6 0.0 9.4e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI84089.1 - 6e-08 32.3 0.0 7.4e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KPI84089.1 - 3.3e-05 23.5 0.1 0.00034 20.2 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI84089.1 - 0.0002 21.4 0.0 0.00039 20.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KPI84089.1 - 0.0024 17.1 0.0 0.045 12.9 0.0 2.5 1 1 1 2 2 2 1 G-protein alpha subunit ATP_bind_1 PF03029.17 KPI84089.1 - 0.022 14.6 1.4 1 9.1 0.2 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 KPI84089.1 - 0.023 14.6 0.1 0.045 13.7 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 KPI84089.1 - 0.037 13.8 0.0 1.7 8.4 0.0 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KPI84089.1 - 0.043 13.3 0.1 0.36 10.3 0.1 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 KPI84089.1 - 0.12 12.4 0.0 14 5.7 0.0 2.3 2 0 0 2 2 2 0 Dynamin family cobW PF02492.19 KPI84089.1 - 0.18 11.3 0.6 1.8 8.1 0.3 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain WD40 PF00400.32 KPI84090.1 - 1.3e-07 32.2 2.8 0.7 10.9 0.0 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI84090.1 - 1.9e-05 24.9 0.0 1.2 9.5 0.0 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DHR-2 PF06920.13 KPI84091.1 - 1.9e-22 79.6 2.7 2.8e-16 59.3 0.0 2.6 3 0 0 3 3 3 2 Dock homology region 2 DOCK-C2 PF14429.6 KPI84091.1 - 2.6e-17 63.3 0.2 5.5e-17 62.2 0.2 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Metal_resist PF13801.6 KPI84092.1 - 3.5 7.8 6.0 0.31 11.2 0.2 2.3 2 0 0 2 2 2 0 Heavy-metal resistance OpgC_C PF10129.9 KPI84093.1 - 0.0065 15.4 1.7 0.0087 15.0 1.7 1.2 1 0 0 1 1 1 1 OpgC protein CLP1_P PF16575.5 KPI84094.1 - 1e-34 120.0 0.0 1.4e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 KPI84094.1 - 0.0024 18.3 0.0 0.0057 17.1 0.0 1.6 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 KPI84094.1 - 0.077 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 N-terminal beta-sandwich domain of polyadenylation factor PTH2 PF01981.16 KPI84095.1 - 1.8e-19 70.1 0.1 3e-19 69.5 0.1 1.3 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF3192 PF11399.8 KPI84095.1 - 0.03 14.3 0.0 0.088 12.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3192) RPAP2_Rtr1 PF04181.13 KPI84097.1 - 0.0035 17.6 0.1 0.083 13.2 0.0 2.5 2 0 0 2 2 2 1 Rtr1/RPAP2 family TPR_9 PF13371.6 KPI84097.1 - 0.057 13.6 0.3 0.14 12.3 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat NYD-SP12_N PF15015.6 KPI84097.1 - 0.14 10.5 0.1 0.21 9.9 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal DnaJ PF00226.31 KPI84098.1 - 4.3e-12 46.0 0.0 8.3e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain HSP70 PF00012.20 KPI84099.1 - 7.1e-36 123.6 0.5 8e-36 123.4 0.5 1.0 1 0 0 1 1 1 1 Hsp70 protein Cep57_CLD PF14073.6 KPI84099.1 - 0.017 15.2 4.7 0.019 15.0 4.7 1.1 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 DUF4404 PF14357.6 KPI84099.1 - 0.083 13.5 2.4 0.093 13.4 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) V-ATPase_H_N PF03224.14 KPI84100.1 - 4.7e-68 229.8 0.9 7.2e-68 229.2 0.9 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 KPI84100.1 - 1.9e-38 131.2 0.2 8.8e-38 129.0 0.0 2.1 2 0 0 2 2 2 1 V-ATPase subunit H CbiK PF06180.11 KPI84100.1 - 0.067 12.5 0.0 0.96 8.7 0.0 2.2 2 0 0 2 2 2 0 Cobalt chelatase (CbiK) Spore_YunB PF09560.10 KPI84100.1 - 0.076 13.0 0.2 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Sporulation protein YunB (Spo_YunB) PB1 PF00564.24 KPI84101.1 - 2.4e-05 24.2 0.1 8.9e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 PB1 domain Sec66 PF09802.9 KPI84101.1 - 1.3 8.6 3.3 2.1 7.9 0.1 2.6 3 0 0 3 3 3 0 Preprotein translocase subunit Sec66 DHHC PF01529.20 KPI84105.1 - 7.1e-32 110.3 2.4 7.1e-32 110.3 2.4 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4500 PF14937.6 KPI84105.1 - 0.062 13.3 0.2 0.18 11.8 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) Ost5 PF05251.12 KPI84105.1 - 1 9.7 6.8 8.2 6.8 0.3 3.2 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 DUF971 PF06155.12 KPI84106.1 - 1e-11 45.3 0.0 3.3e-11 43.7 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF971) DUF393 PF04134.12 KPI84107.1 - 0.0069 17.7 1.3 0.27 12.6 0.3 2.6 2 1 0 2 2 2 2 Protein of unknown function, DUF393 E1_dh PF00676.20 KPI84108.1 - 7.6e-80 268.0 0.0 1.1e-79 267.5 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Cyt-b5 PF00173.28 KPI84109.1 - 1.1e-05 25.5 0.0 2.9e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PRMT5 PF05185.16 KPI84110.1 - 2e-39 135.2 0.0 3.2e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 KPI84110.1 - 4.1e-23 82.2 0.0 7.9e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain DUF3586 PF12131.8 KPI84111.1 - 3.1e-10 40.1 2.9 5.1e-10 39.4 0.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) AAA_5 PF07728.14 KPI84112.1 - 8.7e-83 275.2 0.0 2.2e-31 108.7 0.0 3.6 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KPI84112.1 - 1.8e-06 27.6 0.2 0.003 17.1 0.1 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_16 PF13191.6 KPI84112.1 - 7.5e-06 26.4 5.3 0.03 14.7 0.0 5.0 5 0 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 KPI84112.1 - 1.4e-05 25.3 0.4 0.0086 16.4 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA PF00004.29 KPI84112.1 - 0.00011 22.6 0.0 0.098 13.1 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KPI84112.1 - 0.00036 20.3 0.0 0.13 12.0 0.0 3.3 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_3 PF07726.11 KPI84112.1 - 0.0021 17.9 0.0 0.47 10.3 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KPI84112.1 - 0.0037 17.0 0.0 3.1 7.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain TniB PF05621.11 KPI84112.1 - 0.0044 16.4 0.0 3.8 6.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein TsaE PF02367.17 KPI84112.1 - 0.0067 16.4 0.1 0.2 11.7 0.1 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 KPI84112.1 - 0.0093 16.1 0.0 2.6 8.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.6 KPI84112.1 - 0.015 15.6 1.2 11 6.3 0.0 3.6 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 KPI84112.1 - 0.027 14.2 0.1 15 5.3 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain Rad17 PF03215.15 KPI84112.1 - 0.041 13.8 0.0 0.28 11.1 0.0 2.2 3 0 0 3 3 3 0 Rad17 P-loop domain VWA_2 PF13519.6 KPI84112.1 - 0.074 13.7 0.0 0.27 11.9 0.0 2.1 1 0 0 1 1 1 0 von Willebrand factor type A domain RsgA_GTPase PF03193.16 KPI84112.1 - 0.089 12.7 0.0 5.5 6.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase Mg_chelatase PF01078.21 KPI84112.1 - 0.089 12.2 1.2 1.9 7.8 0.0 3.2 3 1 1 4 4 4 0 Magnesium chelatase, subunit ChlI DnaJ PF00226.31 KPI84113.1 - 1.6e-17 63.4 0.2 1.2e-07 31.7 0.0 2.5 2 0 0 2 2 2 2 DnaJ domain eIF3_subunit PF08597.10 KPI84113.1 - 0.57 10.1 13.6 1.2 9.0 13.6 1.5 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit TMEM65 PF10507.9 KPI84115.1 - 2.4e-30 104.7 0.7 1e-29 102.7 0.7 2.2 1 0 0 1 1 1 1 Transmembrane protein 65 EF-hand_1 PF00036.32 KPI84115.1 - 0.08 12.5 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.6 KPI84115.1 - 0.18 11.3 0.1 0.36 10.4 0.1 1.4 1 0 0 1 1 1 0 EF hand Dpy-30 PF05186.13 KPI84116.1 - 6.1e-08 32.2 0.6 1.2e-07 31.3 0.1 1.8 2 0 0 2 2 2 1 Dpy-30 motif Dppa2_A PF14049.6 KPI84116.1 - 0.39 10.9 0.1 0.39 10.9 0.1 3.0 3 1 0 3 3 3 0 Dppa2/4 conserved region in higher vertebrates DUF1283 PF06932.11 KPI84116.1 - 0.87 9.8 6.4 1.5 9.1 4.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1283) V_ATPase_I PF01496.19 KPI84116.1 - 1.6 6.5 10.3 2.7 5.8 10.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family mit_SMPDase PF14724.6 KPI84118.1 - 0.043 11.8 0.2 0.061 11.3 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase Pkinase PF00069.25 KPI84119.1 - 7.9e-60 202.4 0.0 2.5e-59 200.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84119.1 - 6.6e-43 146.9 0.0 9.5e-43 146.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI84119.1 - 1.4e-05 24.6 0.0 2.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI84119.1 - 0.0034 17.3 3.0 0.4 10.6 3.0 2.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family ASH PF15780.5 KPI84120.1 - 1.3e-06 28.5 2.3 0.014 15.6 0.0 5.2 4 0 0 4 4 4 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin ATG2_CAD PF13329.6 KPI84120.1 - 0.1 12.3 0.4 0.4 10.4 0.4 2.0 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif Snf7 PF03357.21 KPI84120.1 - 4.1 7.0 8.0 8.6 5.9 8.0 1.5 1 0 0 1 1 1 0 Snf7 TPR_1 PF00515.28 KPI84121.1 - 1.2e-08 34.4 1.3 1.7e-06 27.6 0.3 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84121.1 - 3.4e-07 29.9 8.4 1.6e-05 24.7 0.5 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI84121.1 - 7.4e-06 25.6 2.3 0.0016 18.1 0.0 3.0 3 0 0 3 3 3 2 TPR repeat TPR_9 PF13371.6 KPI84121.1 - 0.0056 16.8 4.8 0.0088 16.2 2.9 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI84121.1 - 0.014 15.6 0.1 0.054 13.7 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84121.1 - 0.065 14.1 0.4 0.065 14.1 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ARPC4 PF05856.12 KPI84122.1 - 1.8e-35 122.0 0.0 2.1e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) CCDC144C PF14915.6 KPI84123.1 - 0.0052 15.9 21.5 0.0076 15.4 21.5 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region TACC_C PF05010.14 KPI84123.1 - 0.0086 15.9 26.4 0.012 15.4 26.4 1.1 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TMF_TATA_bd PF12325.8 KPI84123.1 - 0.013 15.8 3.1 0.013 15.8 3.1 3.4 1 1 2 3 3 2 0 TATA element modulatory factor 1 TATA binding Jnk-SapK_ap_N PF09744.9 KPI84123.1 - 0.014 15.6 6.8 0.014 15.6 6.8 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 KPI84123.1 - 0.089 13.2 25.6 0.12 12.8 25.6 1.2 1 0 0 1 1 1 0 Fez1 FlaC_arch PF05377.11 KPI84123.1 - 0.15 12.5 5.0 0.26 11.7 0.9 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 KPI84123.1 - 0.19 10.9 11.3 1.1 8.4 1.5 2.1 2 0 0 2 2 2 0 TMPIT-like protein Spc7 PF08317.11 KPI84123.1 - 0.47 9.3 30.2 0.013 14.4 5.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF3584 PF12128.8 KPI84123.1 - 1.7 6.1 27.3 2.3 5.6 27.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.6 KPI84123.1 - 1.9 7.8 28.8 0.017 14.5 8.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 KPI84123.1 - 2.2 8.7 25.3 5.3 7.5 4.1 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Prominin PF05478.11 KPI84123.1 - 2.9 5.8 10.5 0.14 10.1 1.2 1.9 1 1 0 1 1 1 0 Prominin Filament PF00038.21 KPI84123.1 - 3 7.3 29.6 0.052 13.1 5.0 2.1 1 1 1 2 2 2 0 Intermediate filament protein MAD PF05557.13 KPI84123.1 - 4.5 5.5 28.4 5.9 5.1 28.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein WD40 PF00400.32 KPI84124.1 - 0.0071 17.2 1.0 1.5 9.8 0.3 4.0 3 1 0 3 3 3 1 WD domain, G-beta repeat Aldedh PF00171.22 KPI84125.1 - 0.00012 20.7 2.6 0.058 11.9 0.1 2.9 3 0 0 3 3 3 2 Aldehyde dehydrogenase family LRR_4 PF12799.7 KPI84126.1 - 1.7e-14 53.7 5.2 0.49 10.9 0.1 10.0 11 1 1 12 12 12 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI84126.1 - 7.7e-06 25.6 8.2 0.11 12.7 0.0 8.0 9 0 0 9 9 9 1 Leucine Rich repeat LRR_8 PF13855.6 KPI84126.1 - 0.069 12.9 14.8 34 4.3 0.0 8.0 9 1 0 9 9 9 0 Leucine rich repeat Nop14 PF04147.12 KPI84128.1 - 2.3e-32 112.2 12.7 1.2e-20 73.4 0.1 3.1 2 1 1 3 3 3 3 Nop14-like family DUF1143 PF06608.11 KPI84129.1 - 0.033 14.2 0.2 0.33 11.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1143) DEAD PF00270.29 KPI84130.1 - 1e-43 149.2 0.0 1.9e-43 148.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI84130.1 - 3.2e-23 82.2 0.0 9.1e-23 80.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI84130.1 - 1.2e-06 28.6 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KPI84130.1 - 0.00014 22.2 0.0 0.00032 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Pyr_redox_2 PF07992.14 KPI84131.1 - 1.1e-62 211.9 1.0 1.1e-62 211.9 1.0 1.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KPI84131.1 - 6.9e-24 84.2 0.5 5.2e-20 71.8 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KPI84131.1 - 1.2e-23 83.4 0.2 2.7e-23 82.3 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 KPI84131.1 - 3.3e-15 56.1 0.6 3e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI84131.1 - 4.8e-05 22.2 1.2 0.12 11.1 0.3 2.7 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 KPI84131.1 - 0.00054 19.2 2.8 0.0049 16.0 1.1 2.6 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 KPI84131.1 - 0.0098 15.5 2.0 6.7 6.2 0.3 3.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 KPI84131.1 - 0.019 14.0 4.6 0.012 14.7 1.8 2.2 2 1 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 KPI84131.1 - 0.036 13.4 0.6 0.37 10.1 0.1 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 KPI84131.1 - 0.28 11.2 1.4 2.8 7.9 0.0 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 KPI84131.1 - 0.34 10.2 1.5 0.7 9.2 0.9 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Ribosomal_S11 PF00411.19 KPI84132.1 - 0.00092 19.6 0.0 0.0024 18.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S11 MCM PF00493.23 KPI84133.1 - 6e-67 225.0 0.0 8.9e-67 224.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 KPI84133.1 - 2e-16 60.2 0.1 2.1e-09 37.6 0.1 2.5 2 0 0 2 2 2 2 MCM AAA-lid domain MCM_OB PF17207.3 KPI84133.1 - 1.1e-10 41.4 0.1 2.6e-09 37.0 0.0 2.3 2 0 0 2 2 2 1 MCM OB domain AAA_5 PF07728.14 KPI84133.1 - 4.8e-09 36.3 0.0 1e-08 35.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KPI84133.1 - 0.00016 21.6 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KPI84133.1 - 0.00029 20.3 0.4 0.26 10.6 0.0 2.6 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA PF00004.29 KPI84133.1 - 0.038 14.4 0.0 0.085 13.3 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI84133.1 - 0.068 13.5 0.1 0.26 11.7 0.1 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_2 PF07724.14 KPI84133.1 - 0.23 11.5 0.0 0.49 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_lid_2 PF17863.1 KPI84133.1 - 0.34 10.8 4.4 0.15 11.9 0.2 2.6 3 0 0 3 3 3 0 AAA lid domain Glutaredoxin PF00462.24 KPI84134.1 - 1.8e-14 53.7 0.0 2.7e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Mito_carr PF00153.27 KPI84136.1 - 7.3e-34 115.6 11.4 3.1e-13 49.5 0.1 3.9 4 1 0 4 4 4 3 Mitochondrial carrier protein P16-Arc PF04699.14 KPI84137.1 - 1.5e-05 25.5 0.0 2.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) PTPLA PF04387.14 KPI84138.1 - 2.1e-55 186.9 7.9 3e-55 186.4 7.9 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA DUF4355 PF14265.6 KPI84139.1 - 0.68 10.2 5.4 0.086 13.1 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Ank_3 PF13606.6 KPI84140.1 - 2.6e-06 27.3 0.2 0.0003 21.0 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 KPI84140.1 - 2.3e-05 24.9 0.1 0.0011 19.5 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI84140.1 - 0.00011 22.7 0.0 0.018 15.6 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI84140.1 - 0.032 14.7 0.1 0.12 12.9 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 KPI84140.1 - 0.046 14.1 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ThiC_Rad_SAM PF01964.18 KPI84140.1 - 0.1 11.4 2.9 0.16 10.7 2.9 1.2 1 0 0 1 1 1 0 Radical SAM ThiC family FKBP_N PF01346.18 KPI84140.1 - 5.9 7.9 11.8 24 6.0 6.8 2.5 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PDZ_6 PF17820.1 KPI84142.1 - 1.4e-06 28.0 0.1 2.9e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KPI84142.1 - 4.2e-06 27.0 0.0 6.7e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KPI84142.1 - 4.4e-05 23.8 0.0 7.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF3394 PF11874.8 KPI84142.1 - 0.041 13.6 0.2 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3394) WW PF00397.26 KPI84142.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 WW domain PDZ PF00595.24 KPI84143.1 - 4.1e-07 30.3 0.0 9.2e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KPI84143.1 - 2.5e-05 24.0 0.2 6.6e-05 22.7 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KPI84143.1 - 4.3e-05 23.8 0.0 9.7e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Sld5 PF05916.11 KPI84144.1 - 2.3e-17 63.4 0.0 3.8e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Glycos_transf_4 PF00953.21 KPI84145.1 - 5.8e-45 153.1 11.6 5.8e-45 153.1 11.6 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF456 PF04306.13 KPI84145.1 - 3.4 8.0 13.5 5.7 7.2 0.4 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF456) ADH_zinc_N PF00107.26 KPI84146.1 - 1.8e-28 99.1 0.0 3.1e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KPI84146.1 - 4.7e-17 63.3 0.0 1.2e-16 62.0 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI84146.1 - 8.2e-13 48.2 0.0 2.3e-12 46.7 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 KPI84146.1 - 0.0026 18.0 0.0 0.011 16.0 0.0 1.9 2 0 0 2 2 2 1 TrkA-N domain Semialdhyde_dh PF01118.24 KPI84146.1 - 0.045 14.2 0.0 0.13 12.7 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain TFIIS_C PF01096.18 KPI84149.1 - 9.2e-12 44.6 7.8 9.2e-12 44.6 7.8 3.2 3 1 0 3 3 3 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 KPI84149.1 - 0.014 15.1 1.6 0.014 15.1 1.6 2.5 3 1 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain HypA PF01155.19 KPI84149.1 - 2.2 8.3 12.4 1.3 9.0 2.1 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1451 PF07295.11 KPI84149.1 - 4.3 7.4 12.4 0.058 13.4 2.5 2.5 2 1 0 2 2 2 0 Zinc-ribbon containing domain Amastin PF07344.11 KPI84150.1 - 5.9e-11 42.5 7.8 1e-10 41.7 7.6 1.5 1 1 0 1 1 1 1 Amastin surface glycoprotein MTABC_N PF16185.5 KPI84150.1 - 0.1 12.1 5.1 0.17 11.4 5.1 1.3 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region PMP22_Claudin PF00822.20 KPI84150.1 - 0.28 11.1 10.9 0.72 9.7 10.6 2.0 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family RhodobacterPufX PF11511.8 KPI84150.1 - 0.9 9.2 5.1 0.67 9.6 0.1 3.0 2 1 0 3 3 3 0 Intrinsic membrane protein PufX Amastin PF07344.11 KPI84151.1 - 2.9e-06 27.2 7.1 2.9e-06 27.2 7.1 2.1 2 0 0 2 2 2 1 Amastin surface glycoprotein Glyco_hydro_31 PF01055.26 KPI84154.1 - 3.2e-54 184.8 0.0 5.9e-54 183.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 IQ PF00612.27 KPI84156.1 - 1.4e-10 40.0 12.9 0.0022 17.6 2.2 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif DDRGK PF09756.9 KPI84160.1 - 1.2e-23 83.7 26.2 1.6e-17 63.7 0.0 2.4 3 0 0 3 3 3 2 DDRGK domain MRP-S31 PF15433.6 KPI84160.1 - 1.3 8.6 9.6 1.8 8.2 9.6 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 MAS20 PF02064.15 KPI84160.1 - 10 6.3 14.9 53 3.9 0.0 3.2 3 0 0 3 3 3 0 MAS20 protein import receptor Fungus-induced PF10917.8 KPI84161.1 - 4.4 7.7 6.8 12 6.3 0.0 3.2 4 0 0 4 4 4 0 Fungus-induced protein Pkinase PF00069.25 KPI84162.1 - 6.2e-31 107.7 0.0 1e-24 87.3 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84162.1 - 2.6e-15 56.4 0.0 5.3e-10 39.0 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Rossmann-like PF10727.9 KPI84162.1 - 0.0095 15.8 3.6 0.041 13.8 3.6 2.1 1 0 0 1 1 1 1 Rossmann-like domain Kinase-like PF14531.6 KPI84162.1 - 0.036 13.4 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Peptidase_S77 PF03420.13 KPI84162.1 - 0.17 11.6 0.2 0.33 10.6 0.2 1.4 1 0 0 1 1 1 0 Prohead core protein serine protease Pox_ser-thr_kin PF05445.11 KPI84162.1 - 0.23 10.4 0.1 0.59 9.0 0.0 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Gpr1_Fun34_YaaH PF01184.19 KPI84163.1 - 6.9e-33 114.0 14.4 9.7e-33 113.5 14.4 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 KPI84164.1 - 5.8e-48 163.2 17.5 7.6e-48 162.9 17.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family PCI PF01399.27 KPI84165.1 - 0.00093 19.7 0.0 0.085 13.4 0.0 2.8 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 KPI84165.1 - 0.091 12.9 0.8 0.33 11.2 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Methyltransf_11 PF08241.12 KPI84166.1 - 2.5e-08 34.4 0.1 3.1e-06 27.7 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84166.1 - 8.8e-08 32.8 0.1 0.0012 19.5 0.0 3.4 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.6 KPI84166.1 - 5.5e-05 23.1 0.0 9.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84166.1 - 0.015 16.1 0.0 0.067 13.9 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KPI84166.1 - 0.032 14.0 0.0 4.5 7.0 0.0 2.8 2 1 0 2 2 2 0 Methyltransferase domain Semialdhyde_dh PF01118.24 KPI84167.1 - 0.0028 18.1 0.0 0.0062 17.0 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sec39 PF08314.11 KPI84167.1 - 0.012 14.1 0.1 0.018 13.6 0.1 1.1 1 0 0 1 1 1 0 Secretory pathway protein Sec39 DapB_N PF01113.20 KPI84167.1 - 0.022 14.9 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Polysacc_synt_2 PF02719.15 KPI84167.1 - 0.12 11.5 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 KPI84167.1 - 0.18 11.2 0.0 0.38 10.2 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KPI84167.1 - 0.18 10.9 0.0 0.6 9.2 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein 2-oxoacid_dh PF00198.23 KPI84168.1 - 7.1e-75 251.4 0.1 9e-75 251.1 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 KPI84168.1 - 1.9e-12 47.3 0.3 1.9e-12 47.3 0.3 2.1 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl PF00364.22 KPI84168.1 - 5.3e-11 42.2 0.0 1.9e-10 40.4 0.0 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme Metallophos PF00149.28 KPI84169.1 - 5.2e-06 27.1 0.0 1.4e-05 25.7 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KPI84169.1 - 1.3e-05 25.5 0.0 0.00012 22.4 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pentapeptide_4 PF13599.6 KPI84171.1 - 1.1e-10 41.5 10.3 7.3e-09 35.7 9.7 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 KPI84171.1 - 2.8e-10 39.6 17.5 0.00014 21.4 5.8 4.2 2 1 1 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 KPI84171.1 - 2.2e-05 24.5 20.2 0.058 13.6 4.5 3.6 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) DUF630 PF04783.12 KPI84172.1 - 0.01 16.0 1.8 0.01 16.0 1.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF630) Endonuc-MspI PF09208.10 KPI84172.1 - 0.099 12.0 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Restriction endonuclease MspI Effector_1 PF04518.12 KPI84172.1 - 0.11 11.6 0.1 0.18 10.9 0.1 1.4 1 0 0 1 1 1 0 Effector from type III secretion system Peptidase_M41 PF01434.18 KPI84174.1 - 6.4e-58 195.8 0.5 9.7e-58 195.2 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KPI84174.1 - 3.5e-41 140.7 0.0 6.8e-41 139.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI84174.1 - 1.9e-06 27.6 0.1 5e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KPI84174.1 - 1.9e-05 24.7 0.0 7.2e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI84174.1 - 8.5e-05 22.4 0.0 0.00024 20.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI84174.1 - 0.00011 22.7 0.1 0.00058 20.3 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI84174.1 - 0.00031 21.0 0.2 0.068 13.4 0.0 2.9 2 1 0 3 3 2 1 AAA domain AAA_25 PF13481.6 KPI84174.1 - 0.00045 19.8 1.1 0.048 13.2 0.2 2.9 2 1 1 3 3 3 1 AAA domain TIP49 PF06068.13 KPI84174.1 - 0.00073 18.8 0.0 0.0016 17.7 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 KPI84174.1 - 0.0014 18.6 0.0 0.0049 16.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI84174.1 - 0.0042 17.6 0.0 0.0094 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KPI84174.1 - 0.0043 17.0 0.1 0.028 14.3 0.0 2.1 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 KPI84174.1 - 0.0058 16.4 0.1 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein Rad17 PF03215.15 KPI84174.1 - 0.0061 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_2 PF07724.14 KPI84174.1 - 0.0062 16.7 0.0 0.021 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KPI84174.1 - 0.0072 15.7 0.2 0.016 14.6 0.2 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 KPI84174.1 - 0.0092 16.4 0.0 0.019 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KPI84174.1 - 0.012 14.9 0.1 0.026 13.8 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 KPI84174.1 - 0.026 14.7 0.0 0.068 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KPI84174.1 - 0.039 14.0 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 KPI84174.1 - 0.062 13.7 0.1 0.22 11.9 0.0 2.0 2 0 0 2 2 1 0 RNA helicase Peptidase_M50B PF13398.6 KPI84174.1 - 0.077 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like ATPase PF06745.13 KPI84174.1 - 0.097 12.0 0.1 1.6 8.0 0.0 2.7 3 1 0 3 3 3 0 KaiC AAA_28 PF13521.6 KPI84174.1 - 0.1 12.8 0.0 0.3 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KPI84174.1 - 0.1 13.1 0.4 0.5 10.9 0.2 2.2 2 0 0 2 2 2 0 ABC transporter TniB PF05621.11 KPI84174.1 - 0.11 11.9 0.0 4.4 6.7 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein RIX1 PF08167.12 KPI84175.1 - 6.4e-09 35.8 6.4 1.4e-08 34.7 1.9 3.3 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Adaptin_N PF01602.20 KPI84175.1 - 0.0023 16.6 0.1 0.71 8.4 0.3 2.7 2 1 0 2 2 2 2 Adaptin N terminal region IBN_N PF03810.19 KPI84175.1 - 0.003 17.4 0.1 0.049 13.5 0.0 3.0 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT PF02985.22 KPI84175.1 - 0.0055 16.9 6.0 14 6.2 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 KPI84175.1 - 0.68 10.5 14.3 3.4 8.3 0.0 6.0 6 2 1 7 7 7 0 HEAT-like repeat Pkinase PF00069.25 KPI84176.1 - 6.9e-41 140.3 0.0 7.1e-23 81.3 0.0 4.3 3 2 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84176.1 - 9.4e-35 120.1 0.2 6e-18 65.1 0.0 4.1 3 1 0 3 3 3 3 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI84176.1 - 3.4e-05 22.8 2.0 0.00013 20.9 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase DUF3523 PF12037.8 KPI84176.1 - 0.035 13.5 0.5 0.071 12.5 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) TPR_2 PF07719.17 KPI84178.1 - 5.2e-08 32.4 6.3 0.00075 19.4 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84178.1 - 1.1e-07 31.3 3.4 0.0025 17.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat SNAP PF14938.6 KPI84178.1 - 6.2e-05 22.6 3.8 0.093 12.1 0.0 2.6 3 0 0 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KPI84178.1 - 0.00012 22.0 3.0 0.071 13.3 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI84178.1 - 0.0014 18.3 7.5 0.081 12.6 0.1 3.0 4 0 0 4 4 4 2 TPR repeat TPR_12 PF13424.6 KPI84178.1 - 0.0015 18.8 12.4 0.77 10.1 0.0 5.5 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84178.1 - 0.0018 18.9 0.4 0.03 15.1 0.7 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat COMMD1_N PF17221.3 KPI84178.1 - 0.02 15.2 0.6 8.6 6.7 0.1 2.5 2 0 0 2 2 2 0 COMMD1 N-terminal domain TPR_7 PF13176.6 KPI84178.1 - 0.054 13.5 5.2 0.31 11.2 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.10 KPI84178.1 - 0.12 11.3 0.3 0.29 10.1 0.3 1.6 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 KPI84178.1 - 0.13 12.8 12.3 0.77 10.3 0.5 4.7 5 1 0 5 5 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 KPI84178.1 - 0.27 10.9 0.1 0.27 10.9 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain Alkyl_sulf_dimr PF14863.6 KPI84178.1 - 1.3 9.5 5.1 18 5.8 0.2 2.8 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_6 PF13174.6 KPI84178.1 - 3.2 8.6 5.6 11 6.9 0.0 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TMEM154 PF15102.6 KPI84180.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family DUF4381 PF14316.6 KPI84180.1 - 0.19 12.0 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Shisa PF13908.6 KPI84181.1 - 0.00013 22.3 0.1 0.0002 21.7 0.1 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Orthoreo_P10 PF07204.11 KPI84181.1 - 0.00099 19.0 0.2 0.0022 17.9 0.2 1.6 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 KPI84181.1 - 0.0029 18.5 0.4 0.0072 17.2 0.4 1.7 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DAG1 PF05454.11 KPI84181.1 - 0.0036 16.7 0.1 0.0056 16.1 0.1 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMIE PF16038.5 KPI84181.1 - 0.0045 16.8 0.0 0.0072 16.1 0.0 1.3 1 0 0 1 1 1 1 TMIE protein DUF1129 PF06570.11 KPI84181.1 - 0.0048 16.4 0.1 0.0096 15.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) TMEM52 PF14979.6 KPI84181.1 - 0.0075 16.2 0.4 0.43 10.5 0.0 2.5 2 0 0 2 2 2 1 Transmembrane 52 Rhabdo_glycop PF00974.18 KPI84181.1 - 0.016 13.7 0.2 0.023 13.2 0.2 1.1 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein PRIMA1 PF16101.5 KPI84181.1 - 0.026 14.5 0.1 0.052 13.6 0.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SID-1_RNA_chan PF13965.6 KPI84181.1 - 0.03 12.8 0.1 0.041 12.3 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ASFV_J13L PF05568.11 KPI84181.1 - 0.032 14.0 0.5 0.07 12.9 0.0 1.9 3 0 0 3 3 3 0 African swine fever virus J13L protein Zip PF02535.22 KPI84181.1 - 0.035 13.3 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter MAP17 PF15807.5 KPI84181.1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4834 PF16118.5 KPI84181.1 - 0.14 13.1 0.0 0.28 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Baculo_F PF12259.8 KPI84181.1 - 0.24 9.9 0.1 0.32 9.5 0.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein DUF3357 PF11837.8 KPI84181.1 - 0.72 10.3 3.9 0.32 11.5 0.2 2.3 3 1 0 3 3 2 0 Domain of unknown function (DUF3357) LSR PF05624.14 KPI84181.1 - 1.9 8.6 9.1 0.18 11.8 4.2 1.8 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) TMEM154 PF15102.6 KPI84181.1 - 8.3 6.3 8.8 0.2 11.6 0.3 2.1 1 1 1 2 2 2 0 TMEM154 protein family Pribosyltran PF00156.27 KPI84182.1 - 4.8e-20 71.7 0.0 7.1e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyltran PF00156.27 KPI84183.1 - 1.8e-20 73.1 0.0 2.2e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MWFE PF15879.5 KPI84184.1 - 0.18 12.0 1.4 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Peptidase_M24 PF00557.24 KPI84185.1 - 5.4e-44 150.4 0.1 7.3e-44 150.0 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 BAF1_ABF1 PF04684.13 KPI84185.1 - 0.17 10.9 2.1 0.3 10.1 2.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4833 PF16117.5 KPI84186.1 - 1.5e-18 67.1 0.1 1.5e-08 34.7 0.1 3.2 2 1 0 2 2 2 2 Domain of unknown function (DUF4833) DUF4833 PF16117.5 KPI84187.1 - 3.3e-16 59.5 0.0 8.8e-07 29.0 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4833) Baculo_PEP_C PF04513.12 KPI84189.1 - 0.0003 20.8 2.7 0.0003 20.8 2.7 18.1 11 3 10 21 21 21 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4472 PF14739.6 KPI84189.1 - 0.0053 17.5 7.9 0.0053 17.5 7.9 21.0 10 5 10 21 21 21 1 Domain of unknown function (DUF4472) Pox_A_type_inc PF04508.12 KPI84189.1 - 0.43 10.5 10.2 1.5 8.8 0.4 6.1 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat Spem1 PF15670.5 KPI84190.1 - 4.1 6.9 12.3 1.9 8.0 9.4 1.9 2 0 0 2 2 2 0 Spermatid maturation protein 1 COX17 PF05051.13 KPI84191.1 - 1.4e-14 54.1 8.5 2e-14 53.7 8.5 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) TatD_DNase PF01026.21 KPI84192.1 - 6.8e-42 143.6 0.0 1.6e-41 142.4 0.0 1.6 1 0 0 1 1 1 1 TatD related DNase Ubiquitin_2 PF14560.6 KPI84194.1 - 3.2e-10 40.3 0.0 7.1e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_4 PF12799.7 KPI84194.1 - 5e-10 39.5 5.2 0.0044 17.4 0.2 4.1 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI84194.1 - 9.2e-07 28.5 4.0 0.35 10.3 0.0 4.4 4 1 1 5 5 5 3 Leucine-rich repeat LRR_8 PF13855.6 KPI84194.1 - 4.2e-05 23.2 6.5 0.081 12.7 0.2 4.2 3 2 0 3 3 3 2 Leucine rich repeat ubiquitin PF00240.23 KPI84194.1 - 0.00019 21.1 0.1 0.0018 18.0 0.1 2.2 1 1 0 1 1 1 1 Ubiquitin family YukD PF08817.10 KPI84194.1 - 0.037 14.7 0.1 2.4 8.9 0.0 2.9 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD LRR_6 PF13516.6 KPI84194.1 - 1.1 9.5 5.2 19 5.7 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat Pkinase PF00069.25 KPI84195.1 - 4.8e-48 163.8 0.1 1.9e-17 63.5 0.0 4.2 4 0 0 4 4 4 4 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84195.1 - 2e-21 76.4 0.0 5.6e-07 29.1 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI84195.1 - 0.019 13.8 0.0 0.055 12.2 0.0 1.7 1 0 0 1 1 1 0 Fungal protein kinase 6PF2K PF01591.18 KPI84197.1 - 8.8e-61 205.0 0.0 1.4e-60 204.4 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Ank_2 PF12796.7 KPI84197.1 - 2.6e-11 44.0 0.1 7.2e-11 42.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI84197.1 - 4.4e-11 42.8 0.2 1.3e-10 41.3 0.2 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KPI84197.1 - 1.1e-09 38.7 0.3 1.1e-08 35.4 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI84197.1 - 1.8e-06 28.1 0.3 1.8e-05 24.9 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KPI84197.1 - 3.5e-05 23.9 0.1 0.0057 17.1 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat His_Phos_1 PF00300.22 KPI84197.1 - 3.6e-05 23.6 0.0 0.046 13.4 0.0 3.6 4 0 0 4 4 4 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KPI84197.1 - 0.00015 21.9 1.6 0.001 19.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 KPI84199.1 - 1.7e-36 125.6 0.0 1.1e-35 123.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI84199.1 - 1.1e-25 90.2 0.8 3.4e-25 88.5 0.2 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI84199.1 - 1.8e-07 31.3 0.0 3.6e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KPI84199.1 - 0.00087 18.7 1.2 0.0087 15.4 0.0 2.9 4 0 0 4 4 4 1 U3-containing 90S pre-ribosomal complex subunit DUF4844 PF16133.5 KPI84199.1 - 0.064 13.8 0.8 0.19 12.3 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) LETM1 PF07766.13 KPI84200.1 - 0.00088 18.7 0.0 0.0023 17.3 0.0 1.6 1 1 0 1 1 1 1 LETM1-like protein GST_C_6 PF17171.4 KPI84201.1 - 2e-06 27.5 0.0 5.2e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KPI84201.1 - 0.00019 21.4 0.0 0.00045 20.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KPI84201.1 - 0.0033 17.6 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4663 PF15668.5 KPI84202.1 - 6.1 5.8 12.3 0.13 11.3 5.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4663) GMC_oxred_N PF00732.19 KPI84203.1 - 1.1e-12 47.9 0.0 1.6e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KPI84203.1 - 4e-10 40.4 0.1 3.4e-08 34.1 0.0 3.0 2 1 0 2 2 2 1 GMC oxidoreductase NAD_binding_8 PF13450.6 KPI84203.1 - 0.0021 18.3 1.0 0.0093 16.2 0.5 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 KPI84203.1 - 0.0044 16.1 0.0 0.013 14.6 0.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 KPI84203.1 - 0.0066 15.7 0.1 0.35 10.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI84203.1 - 0.0081 14.9 0.2 0.013 14.2 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 KPI84203.1 - 0.016 14.8 2.0 1.6 8.2 0.1 2.7 2 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KPI84203.1 - 0.035 13.2 1.6 0.051 12.6 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.19 KPI84203.1 - 0.15 11.3 0.0 0.92 8.7 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Pkinase PF00069.25 KPI84204.1 - 3.8e-65 219.9 0.0 7.8e-65 218.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84204.1 - 1.4e-45 155.6 0.0 2.5e-45 154.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI84204.1 - 6.5e-07 28.9 0.0 6.5e-07 28.9 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI84204.1 - 0.017 13.9 0.0 0.017 13.9 0.0 2.9 3 1 0 3 3 3 0 Fungal protein kinase APH PF01636.23 KPI84204.1 - 0.12 12.2 0.0 0.12 12.2 0.0 3.8 2 2 2 4 4 4 0 Phosphotransferase enzyme family MIP-T3_C PF17749.1 KPI84205.1 - 7.2e-51 172.2 4.4 7.2e-51 172.2 4.4 3.1 2 1 0 2 2 2 1 Microtubule-binding protein MIP-T3 C-terminal region MIP-T3 PF10243.9 KPI84205.1 - 6.1e-44 148.6 0.3 2.2e-43 146.8 0.0 2.1 2 1 0 2 2 2 1 Microtubule-binding protein MIP-T3 CH-like domain Nup88 PF10168.9 KPI84205.1 - 0.021 12.6 5.6 0.045 11.6 5.6 1.4 1 0 0 1 1 1 0 Nuclear pore component Fib_alpha PF08702.10 KPI84205.1 - 0.47 10.6 7.3 1.4 9.1 7.3 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family COMP PF11598.8 KPI84205.1 - 6.3 7.3 7.3 2.4 8.7 2.0 2.7 2 1 0 2 2 2 0 Cartilage oligomeric matrix protein peroxidase PF00141.23 KPI84207.1 - 6.4e-10 39.1 0.0 2.2e-09 37.3 0.0 1.9 1 1 1 2 2 2 1 Peroxidase WD40 PF00400.32 KPI84208.1 - 0.00085 20.1 1.9 5.3 8.1 0.1 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat Ad_Cy_reg PF16701.5 KPI84208.1 - 0.017 14.8 0.9 0.036 13.8 0.9 1.5 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain Arf PF00025.21 KPI84210.1 - 9.9e-23 80.5 0.2 1.9e-09 37.2 0.0 4.3 4 0 0 4 4 4 4 ADP-ribosylation factor family G-alpha PF00503.20 KPI84210.1 - 3.9e-09 36.1 0.0 0.0005 19.3 0.1 2.4 2 1 0 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KPI84210.1 - 5.8e-05 23.3 0.0 0.54 10.5 0.0 2.6 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI84210.1 - 0.00067 19.1 0.0 0.25 10.8 0.0 2.6 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 KPI84210.1 - 0.0094 16.5 0.0 0.016 15.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Ras PF00071.22 KPI84210.1 - 0.012 15.2 0.0 33 4.0 0.0 3.8 3 1 0 3 3 3 0 Ras family GTP_EFTU PF00009.27 KPI84210.1 - 0.017 14.7 0.0 0.75 9.3 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 KPI84210.1 - 0.032 14.0 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KPI84210.1 - 0.043 13.9 0.0 0.15 12.1 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 KPI84210.1 - 0.055 13.4 0.0 6.8 6.6 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 KPI84210.1 - 0.11 12.7 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Yip1 PF04893.17 KPI84212.1 - 3.7e-06 26.8 12.1 5.3e-06 26.2 12.1 1.2 1 0 0 1 1 1 1 Yip1 domain AAA_16 PF13191.6 KPI84213.1 - 1.1e-05 25.9 0.6 0.00063 20.2 0.0 3.3 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KPI84213.1 - 0.0022 18.3 0.0 1.6 9.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KPI84213.1 - 0.11 12.9 0.0 0.49 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Kinesin PF00225.23 KPI84213.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain Ribosomal_L38e PF01781.18 KPI84214.1 - 9.8e-30 102.5 5.2 1.2e-29 102.2 5.2 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family GDP_Man_Dehyd PF16363.5 KPI84215.1 - 5.5e-65 219.9 0.0 7e-64 216.3 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KPI84215.1 - 5.8e-52 176.5 0.1 8.4e-52 176.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KPI84215.1 - 6.6e-21 74.7 0.0 3.1e-19 69.2 0.0 2.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 KPI84215.1 - 2.3e-19 69.6 0.0 4.4e-19 68.7 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 KPI84215.1 - 2.4e-15 56.4 0.0 4.9e-15 55.4 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 KPI84215.1 - 9.5e-14 51.0 0.0 3.4e-13 49.2 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Phage_TAC_11 PF11836.8 KPI84215.1 - 0.062 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 Herpes_BLLF1 PF05109.13 KPI84215.1 - 0.092 10.7 0.0 0.13 10.3 0.0 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) KR PF08659.10 KPI84215.1 - 0.094 12.6 0.1 0.31 10.9 0.1 1.8 1 1 0 1 1 1 0 KR domain ThiF PF00899.21 KPI84215.1 - 0.14 11.5 0.0 0.41 10.0 0.0 1.6 2 0 0 2 2 2 0 ThiF family Aminotran_5 PF00266.19 KPI84216.1 - 2e-11 43.5 0.0 2.5e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KPI84216.1 - 0.047 13.0 0.6 0.092 12.0 0.2 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Sec1 PF00995.23 KPI84218.1 - 2.4e-89 301.1 0.0 2.8e-89 300.9 0.0 1.1 1 0 0 1 1 1 1 Sec1 family NleF_casp_inhib PF16809.5 KPI84218.1 - 0.19 11.7 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 NleF caspase inhibitor MRP-S34 PF16053.5 KPI84219.1 - 8.8e-05 22.2 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 ADH_N PF08240.12 KPI84220.1 - 4.2e-29 100.6 4.5 4.2e-29 100.6 4.5 2.3 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI84220.1 - 1.9e-21 76.4 0.1 3.9e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KPI84220.1 - 2.3e-07 30.4 0.7 3.9e-07 29.6 0.7 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 KPI84220.1 - 2.4e-05 23.8 0.2 3.8e-05 23.1 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 KPI84220.1 - 0.0003 21.0 0.5 0.0005 20.3 0.5 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Glu_dehyd_C PF16912.5 KPI84220.1 - 0.00073 19.1 0.1 0.0011 18.5 0.1 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 KPI84220.1 - 0.0015 19.6 0.0 0.0024 18.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 3HCDH_N PF02737.18 KPI84220.1 - 0.0038 17.1 0.8 0.0059 16.5 0.8 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 KPI84220.1 - 0.039 13.4 0.5 0.086 12.3 0.5 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Oxidored_nitro PF00148.19 KPI84220.1 - 0.045 12.5 0.1 0.062 12.0 0.1 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase TrkA_N PF02254.18 KPI84220.1 - 0.062 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 KPI84220.1 - 0.076 13.1 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 KPI84220.1 - 0.096 12.3 0.3 0.2 11.3 0.3 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 KPI84220.1 - 0.16 11.3 0.4 0.32 10.3 0.4 1.5 1 0 0 1 1 1 0 ThiF family RibD_C PF01872.17 KPI84221.1 - 1.1e-11 44.9 0.0 4.3e-11 43.0 0.0 1.8 1 1 0 1 1 1 1 RibD C-terminal domain Ribosomal_L30 PF00327.20 KPI84222.1 - 1.5e-18 66.4 2.2 1.5e-18 66.4 2.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 KPI84222.1 - 2.9e-15 56.2 12.2 5.2e-15 55.5 12.2 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain SVWC PF15430.6 KPI84222.1 - 0.027 14.7 0.3 0.045 14.0 0.3 1.3 1 0 0 1 1 1 0 Single domain von Willebrand factor type C NIF PF03031.18 KPI84223.1 - 8e-52 175.1 0.4 1.7e-51 174.1 0.2 1.6 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase zf_PR_Knuckle PF18445.1 KPI84223.1 - 0.048 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 PR zinc knuckle motif MCM_bind PF09739.9 KPI84224.1 - 8.7e-41 140.0 0.0 1.4e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor Pribosyltran PF00156.27 KPI84225.1 - 4.3e-21 75.1 0.0 5.6e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KPI84225.1 - 2.4e-08 33.7 0.0 3.4e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 KPI84225.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase Pribosyltran PF00156.27 KPI84226.1 - 2.5e-13 49.9 0.0 4.1e-13 49.1 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 KPI84226.1 - 0.065 12.7 0.5 0.4 10.1 0.5 2.3 1 1 0 1 1 1 0 Phosphoribosyl transferase Rhomboid PF01694.22 KPI84227.1 - 3.1e-05 24.0 0.1 5.2e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Rhomboid family FYVE PF01363.21 KPI84232.1 - 7.6e-20 70.8 9.1 1.2e-19 70.2 8.3 1.8 2 0 0 2 2 2 1 FYVE zinc finger HypA PF01155.19 KPI84232.1 - 1.6 8.8 7.7 0.23 11.5 3.0 2.0 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2HC_14 PF18574.1 KPI84232.1 - 4.1 7.3 9.9 0.56 10.1 4.4 2.3 2 0 0 2 2 2 0 C2HC Zing finger domain Pkinase PF00069.25 KPI84234.1 - 1e-56 192.2 0.0 1.2e-56 192.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84234.1 - 1.9e-20 73.3 0.0 2.1e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI84234.1 - 0.065 12.5 0.0 0.087 12.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KPI84234.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KPI84234.1 - 0.17 10.9 0.0 0.25 10.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 KPI84234.1 - 0.18 11.4 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 GDC-P PF02347.16 KPI84235.1 - 7.8e-169 562.1 0.0 2.1e-155 517.8 0.0 2.9 3 0 0 3 3 3 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 KPI84235.1 - 0.00021 20.7 0.0 0.0004 19.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DUF4473 PF14747.6 KPI84235.1 - 0.072 13.7 0.0 0.19 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) Glyoxalase_4 PF13669.6 KPI84236.1 - 2.5e-18 66.3 0.0 3e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 KPI84236.1 - 0.00027 21.1 0.0 0.00031 20.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KPI84236.1 - 0.00043 20.4 0.0 0.00052 20.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Brix PF04427.18 KPI84237.1 - 6.8e-32 111.1 0.0 8.6e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Brix domain LSM PF01423.22 KPI84238.1 - 1.2e-10 41.0 0.0 1.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain HTH_3 PF01381.22 KPI84239.1 - 4.8e-12 45.7 0.0 7.6e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix MBF1 PF08523.10 KPI84239.1 - 2.2e-11 44.0 7.3 3.7e-11 43.3 7.3 1.4 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_19 PF12844.7 KPI84239.1 - 7.8e-07 29.0 0.0 1.1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 KPI84239.1 - 0.00032 21.0 0.1 0.00061 20.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain SidE PF12252.8 KPI84239.1 - 0.0011 16.7 3.1 0.0013 16.4 3.1 1.0 1 0 0 1 1 1 1 Dot/Icm substrate protein HTH_32 PF13565.6 KPI84239.1 - 0.025 15.2 2.8 0.066 13.8 2.8 1.8 1 1 0 1 1 1 0 Homeodomain-like domain MqsA_antitoxin PF15731.5 KPI84239.1 - 0.035 14.2 0.3 0.068 13.3 0.2 1.5 1 1 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_37 PF13744.6 KPI84239.1 - 0.041 13.8 0.5 0.041 13.8 0.5 1.9 1 1 1 2 2 2 0 Helix-turn-helix domain NAD_binding_11 PF14833.6 KPI84239.1 - 0.073 13.3 0.4 0.18 12.0 0.2 1.6 1 1 1 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Pkinase PF00069.25 KPI84240.1 - 8.8e-71 238.3 0.0 1.1e-70 238.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84240.1 - 1.2e-31 109.9 0.1 2.7e-30 105.5 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI84240.1 - 0.038 13.9 0.0 0.091 12.7 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family MYO10_CC PF16735.5 KPI84240.1 - 0.24 11.5 4.5 8.5 6.6 0.1 2.3 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain Fumarate_red_D PF02313.17 KPI84241.1 - 0.092 12.9 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 Fumarate reductase subunit D Peptidase_M24 PF00557.24 KPI84242.1 - 9e-24 84.3 0.9 1.2e-23 84.0 0.9 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Pkinase PF00069.25 KPI84243.1 - 2.4e-58 197.6 0.0 2.7e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84243.1 - 7.2e-34 117.2 0.0 9.1e-34 116.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI84243.1 - 6.5e-06 25.2 0.0 9.1e-06 24.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 KPI84243.1 - 0.0074 16.4 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Kinase-like PF14531.6 KPI84243.1 - 0.096 12.0 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KPI84243.1 - 0.11 11.9 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KPI84244.1 - 2.2e-50 171.5 0.0 4.4e-50 170.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84244.1 - 2.2e-25 89.4 0.0 2.4e-20 72.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase CAP_GLY PF01302.25 KPI84244.1 - 2.7e-16 59.3 0.9 5.2e-16 58.4 0.9 1.5 1 0 0 1 1 1 1 CAP-Gly domain Kinase-like PF14531.6 KPI84244.1 - 4.1e-05 23.0 0.0 0.015 14.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KPI84244.1 - 0.067 12.5 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sensor PF13796.6 KPI84244.1 - 0.1 12.7 0.2 0.21 11.6 0.1 1.6 1 1 0 1 1 1 0 Putative sensor Pkinase_fungal PF17667.1 KPI84244.1 - 0.16 10.7 0.5 0.42 9.3 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase DER1 PF04511.15 KPI84245.1 - 1.3e-33 116.6 9.6 1.5e-33 116.4 9.6 1.0 1 0 0 1 1 1 1 Der1-like family Saf_2TM PF18303.1 KPI84245.1 - 0.74 9.4 3.0 0.69 9.5 0.7 2.0 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain SNARE PF05739.19 KPI84246.1 - 1.4e-09 37.8 0.8 7.7e-09 35.4 0.4 2.4 2 0 0 2 2 2 1 SNARE domain PspA_IM30 PF04012.12 KPI84246.1 - 0.0013 18.3 3.4 0.0016 18.1 2.1 1.6 1 1 0 1 1 1 1 PspA/IM30 family Methyltransf_33 PF10017.9 KPI84246.1 - 0.017 14.3 0.1 0.041 13.0 0.0 1.6 1 1 1 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent Spc7 PF08317.11 KPI84246.1 - 0.14 11.0 12.4 0.089 11.7 1.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Syntaxin_2 PF14523.6 KPI84246.1 - 0.34 11.3 10.4 0.92 9.9 3.9 2.8 2 2 0 2 2 2 0 Syntaxin-like protein DASH_Spc34 PF08657.10 KPI84246.1 - 0.86 9.4 7.5 0.67 9.7 3.2 2.0 1 1 1 2 2 2 0 DASH complex subunit Spc34 Spectrin PF00435.21 KPI84246.1 - 1.1 9.8 8.8 6.1 7.4 0.5 2.7 2 1 0 2 2 2 0 Spectrin repeat SlyX PF04102.12 KPI84246.1 - 2.4 8.8 14.5 3.9 8.2 0.4 3.6 3 2 1 4 4 4 0 SlyX Med9 PF07544.13 KPI84246.1 - 5.8 7.1 7.8 3.4 7.8 1.0 2.5 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Clathrin_lg_ch PF01086.17 KPI84247.1 - 3.9e-07 30.4 4.6 4.9e-07 30.0 4.5 1.5 1 1 0 1 1 1 1 Clathrin light chain Hamartin PF04388.12 KPI84247.1 - 0.16 10.6 4.1 0.18 10.5 4.1 1.1 1 0 0 1 1 1 0 Hamartin protein Fibrillarin PF01269.17 KPI84248.1 - 2.5e-99 331.0 0.0 2.9e-99 330.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 KPI84248.1 - 2.1e-07 30.9 0.0 2.9e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 KPI84248.1 - 0.0077 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Lar_N PF09861.9 KPI84248.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Lactate racemase N-terminal domain DnaJ PF00226.31 KPI84250.1 - 9.8e-19 67.3 0.3 9.8e-19 67.3 0.3 2.6 2 0 0 2 2 2 1 DnaJ domain SH3_9 PF14604.6 KPI84251.1 - 1.3e-09 37.7 0.0 2.8e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KPI84251.1 - 1.6e-07 30.8 0.0 3e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KPI84251.1 - 0.0001 21.9 0.0 0.00028 20.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Auts2 PF15336.6 KPI84251.1 - 0.17 12.0 2.5 0.15 12.2 0.4 1.9 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein Pkinase PF00069.25 KPI84252.1 - 4.1e-65 219.8 0.0 5.4e-65 219.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84252.1 - 1.2e-39 136.2 0.0 1.7e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI84252.1 - 1.6e-06 27.2 0.0 2.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KPI84252.1 - 7.5e-06 25.4 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zinc_ribbon_2 PF13240.6 KPI84252.1 - 0.0015 18.1 3.4 0.003 17.2 3.4 1.5 1 0 0 1 1 1 1 zinc-ribbon domain APH PF01636.23 KPI84252.1 - 0.0039 17.1 0.0 0.32 10.9 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family DZR PF12773.7 KPI84252.1 - 0.0048 16.9 1.1 0.01 15.9 1.1 1.4 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 KPI84252.1 - 0.014 15.4 0.5 0.026 14.6 0.5 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Prok-RING_1 PF14446.6 KPI84252.1 - 0.072 13.0 3.4 0.19 11.7 3.4 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Kinase-like PF14531.6 KPI84252.1 - 0.1 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like ADK_lid PF05191.14 KPI84252.1 - 0.11 12.5 1.6 0.23 11.5 1.6 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid Cript PF10235.9 KPI84252.1 - 0.2 12.3 1.7 0.43 11.2 1.7 1.5 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT NOB1_Zn_bind PF08772.11 KPI84252.1 - 0.32 11.2 3.8 0.65 10.2 3.8 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Zn_Tnp_IS91 PF14319.6 KPI84252.1 - 0.53 10.3 2.4 1.1 9.3 2.4 1.4 1 0 0 1 1 1 0 Transposase zinc-binding domain Nudix_N_2 PF14803.6 KPI84252.1 - 1.2 9.1 3.6 7.8 6.5 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal zf-NADH-PPase PF09297.11 KPI84252.1 - 1.4 8.6 5.0 1.2 8.9 1.1 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF2576 PF10845.8 KPI84252.1 - 2 8.1 3.9 2.4 7.8 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2576) UPF0547 PF10571.9 KPI84252.1 - 3 8.0 4.6 9.8 6.4 0.4 2.4 1 1 1 2 2 2 0 Uncharacterised protein family UPF0547 HpcH_HpaI PF03328.14 KPI84253.1 - 2.1e-23 82.6 0.0 1.3e-10 40.8 0.0 3.0 1 1 1 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 KPI84253.1 - 3e-14 52.9 0.0 1.1e-08 34.6 0.0 2.5 2 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold DUF563 PF04577.14 KPI84254.1 - 3.9e-07 30.4 0.0 8e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PA_decarbox PF05870.11 KPI84256.1 - 1.2e-72 242.7 0.3 1.3e-72 242.6 0.3 1.0 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) MoaF PF10703.9 KPI84256.1 - 0.055 13.4 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 MoaF N-terminal domain Kinesin PF00225.23 KPI84257.1 - 2.7e-56 190.9 0.0 1.1e-40 139.6 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI84257.1 - 6.2e-10 39.2 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding CR6_interact PF10147.9 KPI84257.1 - 0.52 10.0 4.6 1.1 9.0 4.6 1.4 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF2205 PF10224.9 KPI84257.1 - 0.53 10.3 2.8 2.3 8.3 2.8 2.1 1 0 0 1 1 1 0 Short coiled-coil protein Spc7 PF08317.11 KPI84257.1 - 1.3 7.8 8.2 2.2 7.1 8.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein bZIP_1 PF00170.21 KPI84257.1 - 3.4 7.8 5.8 11 6.2 5.8 1.9 1 0 0 1 1 1 0 bZIP transcription factor DUF3552 PF12072.8 KPI84257.1 - 4.8 6.5 11.1 8.6 5.7 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Mlh1_C PF16413.5 KPI84258.1 - 8.1e-31 107.4 0.0 1.4e-17 64.0 0.0 3.4 3 1 0 3 3 3 2 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 KPI84258.1 - 9.2e-23 80.2 0.0 1.8e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KPI84258.1 - 1e-08 35.1 0.0 2.3e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KPI84258.1 - 2.7e-05 24.6 0.0 6.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPP-2 PF04979.14 KPI84258.1 - 0.0012 19.6 0.2 0.0041 17.9 0.2 1.9 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) P5CR_dimer PF14748.6 KPI84259.1 - 0.16 12.2 1.6 0.5 10.7 1.0 2.2 1 1 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation Anophelin PF10731.9 KPI84259.1 - 0.64 9.9 2.2 1 9.3 0.1 2.4 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito Atg14 PF10186.9 KPI84260.1 - 0.36 9.9 15.4 0.5 9.4 15.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF16 PF01519.16 KPI84260.1 - 1.1 9.8 6.6 0.55 10.8 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 UPF0242 PF06785.11 KPI84260.1 - 3.4 7.7 20.7 2.1 8.4 15.2 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Med7 PF05983.11 KPI84260.1 - 5.2 7.1 8.7 0.1 12.7 1.1 2.0 2 1 0 2 2 2 0 MED7 protein Stevor PF17410.2 KPI84262.1 - 0.0044 16.6 1.0 0.2 11.2 0.0 2.6 2 0 0 2 2 2 2 Subtelomeric Variable Open Reading frame zf-C2H2_4 PF13894.6 KPI84263.1 - 0.47 11.4 3.3 4.1 8.5 0.5 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI84263.1 - 0.98 10.0 5.7 0.61 10.7 0.4 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type UQ_con PF00179.26 KPI84264.1 - 1.9e-41 141.0 0.0 6.6e-41 139.2 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KPI84264.1 - 0.00079 19.1 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B FtsJ PF01728.19 KPI84265.1 - 9.5e-64 214.7 0.0 1.2e-63 214.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Caskin-Pro-rich PF16907.5 KPI84265.1 - 0.45 11.1 6.9 0.14 12.7 3.3 2.0 2 0 0 2 2 2 0 Proline rich region of Caskin proteins RPN6_N PF18055.1 KPI84266.1 - 9.6e-29 100.1 0.2 9.6e-29 100.1 0.2 2.7 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 KPI84266.1 - 1.7e-11 44.5 1.5 2.8e-11 43.9 0.1 2.1 2 0 0 2 2 2 1 PCI domain DDRGK PF09756.9 KPI84266.1 - 0.0016 18.0 0.1 0.0016 18.0 0.1 2.3 2 0 0 2 2 2 1 DDRGK domain DUF4381 PF14316.6 KPI84266.1 - 0.0053 17.0 1.9 0.0053 17.0 1.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) Pkinase PF00069.25 KPI84267.1 - 9.1e-57 192.4 0.0 1.1e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84267.1 - 7.3e-19 68.1 0.0 1.4e-18 67.1 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI84267.1 - 2.1e-05 24.6 2.6 0.00042 20.3 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 KPI84267.1 - 0.0068 16.0 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Snurportin1 PF11538.8 KPI84268.1 - 0.016 15.4 0.6 0.037 14.2 0.6 1.6 1 0 0 1 1 1 0 Snurportin1 UAA PF08449.11 KPI84269.1 - 2.4e-13 50.0 15.4 5.6e-09 35.6 2.3 3.4 3 1 0 3 3 3 2 UAA transporter family EamA PF00892.20 KPI84269.1 - 1.7 8.8 14.2 1.2 9.4 8.6 2.6 2 0 0 2 2 2 0 EamA-like transporter family Glyco_transf_10 PF00852.19 KPI84270.1 - 9.5e-15 54.8 0.0 2.4e-10 40.4 0.0 3.0 3 0 0 3 3 3 2 Glycosyltransferase family 10 (fucosyltransferase) C-term RNase_PH PF01138.21 KPI84271.1 - 4.9e-17 62.7 0.0 1.1e-16 61.5 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 BPL_LplA_LipB PF03099.19 KPI84272.1 - 1.9e-08 34.3 0.0 4.2e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family SNAD1 PF18744.1 KPI84272.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 1 zf-C2H2 PF00096.26 KPI84273.1 - 6.7e-06 26.3 11.2 0.0022 18.3 2.0 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KPI84273.1 - 1.9e-05 25.1 11.0 0.025 15.4 1.5 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KPI84273.1 - 0.00048 20.8 0.1 1.7 9.3 0.0 2.4 2 0 0 2 2 2 2 Zinc finger C2H2-type, 3 repeats DUF629 PF04780.12 KPI84273.1 - 0.013 14.1 0.2 3.4 6.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf-met2 PF12907.7 KPI84273.1 - 0.015 15.4 1.2 0.048 13.8 1.2 1.9 1 0 0 1 1 1 0 Zinc-binding zf-H2C2_2 PF13465.6 KPI84273.1 - 0.048 14.1 3.7 2 9.0 0.6 2.7 2 0 0 2 2 2 0 Zinc-finger double domain FYVE PF01363.21 KPI84273.1 - 0.12 12.6 0.6 11 6.3 0.2 2.3 2 0 0 2 2 2 0 FYVE zinc finger zf-C2H2_2 PF12756.7 KPI84273.1 - 0.18 12.1 4.0 1.4 9.3 0.6 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KPI84273.1 - 0.41 11.1 4.1 0.49 10.9 1.7 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KPI84273.1 - 0.43 10.6 7.9 0.8 9.8 0.9 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger FOXP-CC PF16159.5 KPI84273.1 - 0.46 11.2 1.9 8.9 7.0 0.1 2.4 2 0 0 2 2 2 0 FOXP coiled-coil domain OrsD PF12013.8 KPI84273.1 - 0.51 10.8 3.5 1.8 9.0 0.5 2.2 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-Di19 PF05605.12 KPI84273.1 - 4.3 7.7 5.7 39 4.7 2.7 2.6 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF1601 PF07671.11 KPI84274.1 - 0.056 13.3 0.2 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1601) MAD PF05557.13 KPI84274.1 - 0.077 11.4 30.6 0.12 10.7 30.6 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein FPP PF05911.11 KPI84274.1 - 0.17 10.0 31.2 0.018 13.2 22.0 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil FlaC_arch PF05377.11 KPI84274.1 - 2.5 8.5 9.8 7.4 7.1 0.9 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 KPI84274.1 - 5.7 7.0 37.8 1.4 8.9 12.6 3.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FA_desaturase PF00487.24 KPI84275.1 - 1.9e-36 126.2 20.7 1.9e-36 126.2 20.7 1.4 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KPI84275.1 - 8.6e-05 22.6 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BCNT PF07572.12 KPI84276.1 - 0.023 14.8 0.7 0.047 13.8 0.7 1.5 1 0 0 1 1 1 0 Bucentaur or craniofacial development TetR_C_15 PF17918.1 KPI84276.1 - 3 8.7 6.9 0.56 11.0 1.2 2.6 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ResB PF05140.14 KPI84277.1 - 0.025 13.3 0.1 0.031 13.0 0.1 1.1 1 0 0 1 1 1 0 ResB-like family VWA_2 PF13519.6 KPI84279.1 - 1.9e-13 51.0 0.0 6.3e-13 49.3 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain UIM PF02809.20 KPI84279.1 - 1.8e-06 27.4 16.4 0.00021 21.0 2.5 3.5 2 1 1 3 3 3 3 Ubiquitin interaction motif VWA PF00092.28 KPI84279.1 - 0.016 15.5 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain RAP80_UIM PF18282.1 KPI84279.1 - 0.041 13.7 5.3 0.28 11.0 0.1 3.1 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif EF-hand_7 PF13499.6 KPI84280.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair PMSR PF01625.21 KPI84281.1 - 6.4e-51 172.5 3.2 8e-51 172.2 3.2 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Chorein_N PF12624.7 KPI84282.1 - 9.8e-07 28.9 0.0 5e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KPI84282.1 - 0.0043 16.9 0.1 0.017 15.0 0.1 2.1 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 KPI84282.1 - 0.012 15.4 0.0 0.033 13.9 0.0 1.7 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Aa_trans PF01490.18 KPI84283.1 - 3.8e-59 200.4 29.6 4.4e-59 200.2 29.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI84283.1 - 1.3e-07 31.0 10.7 1.3e-07 31.0 10.7 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family 3HCDH PF00725.22 KPI84284.1 - 4e-11 43.4 0.2 3.7e-06 27.5 0.2 2.6 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain HSCB_C PF07743.13 KPI84285.1 - 0.11 13.1 1.1 2.6 8.6 0.0 2.9 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Ank_2 PF12796.7 KPI84286.1 - 8.7e-09 35.9 0.0 1e-07 32.4 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI84286.1 - 1.9e-08 33.9 0.0 0.0042 17.5 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KPI84286.1 - 3.2e-07 30.8 0.0 0.00011 22.6 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI84286.1 - 0.00059 20.2 0.1 0.033 14.6 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KPI84286.1 - 0.0022 18.3 0.0 0.0082 16.4 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Aminotran_1_2 PF00155.21 KPI84287.1 - 3e-50 171.4 0.0 3.5e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KPI84287.1 - 0.006 15.9 0.0 0.013 14.8 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KPI84287.1 - 0.026 13.9 0.0 5.2 6.3 0.0 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family adh_short PF00106.25 KPI84288.1 - 1.1e-41 142.5 0.3 2.1e-41 141.5 0.2 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI84288.1 - 1.2e-27 97.0 0.2 1.8e-27 96.4 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI84288.1 - 3.5e-15 56.4 0.5 3.5e-15 56.4 0.5 1.4 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 KPI84288.1 - 0.019 14.1 0.1 0.029 13.5 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein AtpR PF12966.7 KPI84288.1 - 0.38 11.2 0.1 0.38 11.2 0.1 2.5 3 0 0 3 3 3 0 N-ATPase, AtpR subunit DNA_ligase_ZBD PF03119.16 KPI84289.1 - 0.026 14.5 0.3 0.091 12.8 0.3 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Med26 PF08711.11 KPI84289.1 - 0.072 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 TFIIS helical bundle-like domain ECH_1 PF00378.20 KPI84291.1 - 2.6e-49 167.8 0.2 3e-49 167.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI84291.1 - 3e-22 79.6 0.5 1.3e-21 77.5 0.5 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DEAD PF00270.29 KPI84292.1 - 2.8e-44 151.0 0.2 4.1e-44 150.4 0.2 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI84292.1 - 1.4e-28 99.4 1.0 1.2e-27 96.4 1.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KPI84292.1 - 0.0005 19.4 0.1 0.00074 18.8 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.6 KPI84292.1 - 0.013 15.9 0.1 0.022 15.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KPI84292.1 - 0.034 14.4 0.4 0.092 13.0 0.4 1.8 1 1 0 1 1 1 0 AAA domain Thioredoxin PF00085.20 KPI84293.1 - 4.5e-05 23.4 0.0 9e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KPI84293.1 - 0.00021 21.6 0.1 0.016 15.5 0.0 2.7 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KPI84293.1 - 0.0033 17.9 0.1 0.33 11.4 0.0 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain TIL PF01826.17 KPI84294.1 - 0.047 14.0 0.4 0.16 12.3 0.4 1.9 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain Dpy-30 PF05186.13 KPI84294.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif FAM104 PF15434.6 KPI84296.1 - 0.11 13.1 2.2 0.21 12.2 1.4 1.9 2 0 0 2 2 2 0 Family 104 COX15-CtaA PF02628.15 KPI84297.1 - 4.3e-103 344.8 6.1 5.3e-103 344.5 6.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Metallophos PF00149.28 KPI84298.1 - 7.4e-35 121.3 0.1 9.2e-35 121.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf_UBZ PF18439.1 KPI84298.1 - 0.14 11.7 0.1 16 5.2 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger VitD-bind_III PF09164.10 KPI84298.1 - 0.17 11.9 1.0 0.4 10.7 1.0 1.6 1 0 0 1 1 1 0 Vitamin D binding protein, domain III SelR PF01641.18 KPI84299.1 - 3.9e-40 136.7 0.0 4.6e-40 136.5 0.0 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 KPI84299.1 - 0.0095 15.6 0.8 0.22 11.3 0.1 2.5 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 KPI84299.1 - 0.075 13.2 1.2 0.31 11.3 0.0 2.0 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TF_Zn_Ribbon PF08271.12 KPI84299.1 - 0.079 12.5 1.9 1 8.9 0.2 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Endonuclease_7 PF02945.15 KPI84299.1 - 0.15 12.0 1.8 0.61 10.0 1.7 2.1 1 1 0 1 1 1 0 Recombination endonuclease VII DZR PF12773.7 KPI84299.1 - 1.5 8.9 6.9 3.7 7.6 1.3 2.6 1 1 1 2 2 2 0 Double zinc ribbon MoaC PF01967.21 KPI84300.1 - 1.6e-23 83.3 0.0 6.5e-23 81.3 0.0 2.2 1 1 0 1 1 1 1 MoaC family Adaptin_N PF01602.20 KPI84302.1 - 2.3e-70 237.6 13.2 2.9e-70 237.3 13.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 KPI84302.1 - 3.4e-31 108.4 0.4 7.2e-31 107.4 0.4 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 KPI84302.1 - 7.8e-23 80.8 0.1 1.8e-22 79.6 0.1 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 KPI84302.1 - 3.5e-11 43.3 0.8 1.4e-06 28.6 0.0 4.4 2 1 2 4 4 4 2 HEAT repeats Cnd1 PF12717.7 KPI84302.1 - 2.1e-07 31.1 11.8 0.00023 21.3 0.5 4.1 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KPI84302.1 - 9.6e-05 22.3 5.5 7.9 7.0 0.1 5.7 5 0 0 5 5 5 3 HEAT repeat IQ PF00612.27 KPI84303.1 - 3.4e-09 35.7 85.8 0.0016 18.1 0.4 12.7 12 0 0 12 12 12 8 IQ calmodulin-binding motif TPR_2 PF07719.17 KPI84303.1 - 0.072 13.2 1.0 1.7 8.9 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-CRD PF17979.1 KPI84303.1 - 3.6 7.7 6.9 2.7 8.1 0.2 3.2 3 0 0 3 3 3 0 Cysteine rich domain with multizinc binding regions ADP_ribosyl_GH PF03747.14 KPI84304.1 - 3.6e-10 40.1 0.5 2.6e-06 27.4 0.1 2.4 2 1 0 2 2 2 2 ADP-ribosylglycohydrolase LRR_4 PF12799.7 KPI84305.1 - 1.2e-09 38.3 3.8 0.00067 20.0 0.1 4.4 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI84305.1 - 2.8e-08 33.4 2.8 0.0012 18.5 0.5 4.3 3 2 1 5 5 5 3 Leucine rich repeat IQ PF00612.27 KPI84305.1 - 3.2e-08 32.7 11.0 0.00082 19.0 2.8 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif LRR_9 PF14580.6 KPI84305.1 - 0.0028 17.2 0.2 0.16 11.5 0.0 2.5 2 0 0 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 KPI84305.1 - 0.01 15.8 0.6 36 4.8 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KPI84305.1 - 0.048 14.2 1.5 93 4.2 0.1 4.9 5 1 0 5 5 5 0 Leucine Rich Repeat HEAT_2 PF13646.6 KPI84306.1 - 4.3e-07 30.2 22.6 0.013 15.9 5.7 7.1 4 2 2 7 7 7 2 HEAT repeats SF3b1 PF08920.10 KPI84306.1 - 1e-06 29.3 9.1 0.00019 21.9 9.1 3.1 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 Adaptin_N PF01602.20 KPI84306.1 - 2.8e-05 22.9 3.9 0.00098 17.8 2.1 2.9 2 1 0 2 2 2 1 Adaptin N terminal region UME PF08064.13 KPI84306.1 - 3.5e-05 23.6 1.2 0.0029 17.5 0.1 4.0 4 1 0 4 4 4 1 UME (NUC010) domain CLASP_N PF12348.8 KPI84306.1 - 5.7e-05 22.8 3.3 0.077 12.6 0.1 5.0 6 0 0 6 6 6 1 CLASP N terminal CTD PF12815.7 KPI84306.1 - 0.00015 22.2 15.8 0.0017 18.9 2.6 3.3 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 NUC173 PF08161.12 KPI84306.1 - 0.0014 18.4 3.2 0.73 9.5 0.0 4.3 6 0 0 6 6 6 1 NUC173 domain DRIM PF07539.12 KPI84306.1 - 0.0024 16.3 2.6 0.48 8.7 0.5 2.8 2 1 0 2 2 2 2 Down-regulated in metastasis Cnd1 PF12717.7 KPI84306.1 - 0.0054 16.8 6.0 0.62 10.1 0.3 3.8 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KPI84306.1 - 0.033 14.7 26.3 2.8 8.5 0.1 8.0 7 2 2 9 9 9 0 HEAT-like repeat HEAT PF02985.22 KPI84306.1 - 0.041 14.1 15.8 7.5 7.1 0.3 7.5 7 0 0 7 7 7 0 HEAT repeat Tti2 PF10521.9 KPI84306.1 - 0.055 13.0 0.1 1.1 8.7 0.0 2.9 2 0 0 2 2 2 0 Tti2 family DUF1308 PF07000.11 KPI84306.1 - 0.057 13.4 0.2 5.1 7.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1308) MMS19_N PF14500.6 KPI84306.1 - 0.08 12.5 0.0 7.2 6.1 0.0 3.5 3 1 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II ParcG PF10274.9 KPI84306.1 - 0.098 12.8 0.1 0.098 12.8 0.1 3.5 5 0 0 5 5 5 0 Parkin co-regulated protein LexA_DNA_bind PF01726.16 KPI84306.1 - 0.14 12.0 0.1 25 4.7 0.0 3.2 3 0 0 3 3 3 0 LexA DNA binding domain DHO_dh PF01180.21 KPI84306.1 - 0.2 10.8 0.1 0.36 10.0 0.1 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase FapA PF03961.13 KPI84309.1 - 4.5 5.8 15.0 2.3 6.7 8.5 2.3 1 1 1 2 2 2 0 Flagellar Assembly Protein A LRR_8 PF13855.6 KPI84310.1 - 0.051 13.3 0.0 0.21 11.4 0.0 2.1 1 0 0 1 1 1 0 Leucine rich repeat JAB PF01398.21 KPI84311.1 - 1.1e-27 96.3 0.0 2.5e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KPI84311.1 - 3.9e-08 33.1 0.0 6.3e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.6 KPI84311.1 - 0.00095 19.6 0.2 0.0022 18.4 0.2 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function ABC_membrane PF00664.23 KPI84313.1 - 3.2e-37 128.7 26.3 7.8e-19 68.4 11.4 3.5 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 KPI84313.1 - 4e-35 121.3 0.0 1.5e-19 70.9 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KPI84313.1 - 1.3e-09 37.8 0.0 0.026 13.9 0.0 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KPI84313.1 - 2.9e-08 33.9 0.2 0.035 13.9 0.0 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KPI84313.1 - 4e-06 26.5 0.1 0.042 13.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 KPI84313.1 - 0.00014 22.3 3.6 0.007 16.8 0.0 3.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 KPI84313.1 - 0.00026 21.5 0.2 0.2 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KPI84313.1 - 0.0003 20.7 0.0 0.3 11.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KPI84313.1 - 0.00065 19.8 0.3 0.065 13.3 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KPI84313.1 - 0.013 15.8 0.1 0.19 12.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 KPI84313.1 - 0.013 14.5 0.0 0.19 10.7 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 KPI84313.1 - 0.021 14.4 0.2 0.97 9.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 KPI84313.1 - 0.022 15.2 0.2 14 6.1 0.0 3.4 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 KPI84313.1 - 0.074 13.0 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 KPI84313.1 - 0.11 11.8 0.3 1.5 8.1 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 KPI84313.1 - 0.11 12.6 0.6 1.7 8.7 0.2 2.4 2 0 0 2 2 2 0 Dynamin family RNA12 PF10443.9 KPI84313.1 - 0.13 11.0 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein DUF87 PF01935.17 KPI84313.1 - 0.18 11.9 0.1 4.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 KPI84313.1 - 0.19 11.2 0.3 15 5.0 0.0 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region Adeno_IVa2 PF02456.15 KPI84313.1 - 0.26 10.0 0.1 0.71 8.6 0.0 1.7 2 0 0 2 2 2 0 Adenovirus IVa2 protein AIG1 PF04548.16 KPI84313.1 - 0.39 10.0 0.9 1 8.6 0.2 1.9 2 0 0 2 2 2 0 AIG1 family Zn-ribbon_8 PF09723.10 KPI84314.1 - 0.006 16.7 0.2 0.011 15.8 0.2 1.5 1 0 0 1 1 1 1 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 KPI84314.1 - 0.63 10.0 4.9 1.2e+02 2.8 5.0 2.5 1 1 0 1 1 1 0 SprT-like zinc ribbon domain Abhydrolase_2 PF02230.16 KPI84316.1 - 9.7e-40 136.7 0.0 1.2e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KPI84316.1 - 4.1e-05 23.0 0.6 0.21 10.8 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI84316.1 - 0.002 17.8 0.5 0.47 10.0 0.0 2.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KPI84316.1 - 0.0053 17.4 0.2 0.0068 17.0 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 KPI84316.1 - 0.012 15.2 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Esterase_phd PF10503.9 KPI84316.1 - 0.029 13.8 0.4 0.057 12.9 0.3 1.5 1 1 0 1 1 1 0 Esterase PHB depolymerase DUF726 PF05277.12 KPI84316.1 - 0.073 12.0 0.1 0.096 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Abhydrolase_3 PF07859.13 KPI84316.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 KPI84316.1 - 0.16 11.6 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative esterase FSH1 PF03959.13 KPI84316.1 - 0.16 11.6 0.2 0.44 10.2 0.2 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF3619 PF12279.8 KPI84317.1 - 0.14 12.5 2.8 0.91 9.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) SPRY PF00622.28 KPI84319.1 - 1.8e-06 28.1 0.0 5e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 SPRY domain Cyclin PF08613.11 KPI84320.1 - 1.8e-18 67.5 0.1 1.8e-18 67.5 0.1 1.8 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 KPI84320.1 - 2.8e-07 30.3 0.1 5.8e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KPI84321.1 - 1e-21 78.0 0.1 1e-21 78.0 0.1 2.4 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 KPI84321.1 - 4.6e-05 23.2 0.2 7.8e-05 22.4 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PFU PF09070.11 KPI84322.1 - 1.1e-24 86.9 0.2 2.2e-24 85.9 0.2 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 KPI84322.1 - 2.7e-21 75.5 22.6 3e-06 27.9 0.2 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat PUL PF08324.11 KPI84322.1 - 5e-11 42.4 1.8 8.4e-11 41.6 1.8 1.3 1 0 0 1 1 1 1 PUL domain PQQ_3 PF13570.6 KPI84322.1 - 0.079 13.5 0.1 4 8.1 0.0 3.4 3 0 0 3 3 3 0 PQQ-like domain ANAPC4_WD40 PF12894.7 KPI84322.1 - 0.13 12.6 0.4 6.3 7.2 0.0 3.3 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DEC-1_N PF04625.13 KPI84322.1 - 0.71 8.8 10.9 1.2 8.0 10.9 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region PPTA PF01239.22 KPI84323.1 - 0.29 10.9 12.2 1.2 9.0 4.0 3.1 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat Zip PF02535.22 KPI84325.1 - 2.2e-40 138.9 7.6 2.9e-40 138.5 7.6 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Peptidase_M16 PF00675.20 KPI84327.1 - 1.4e-34 119.2 0.0 2.5e-34 118.4 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 KPI84327.1 - 8e-31 107.4 0.0 1.8e-28 99.6 0.0 2.3 2 0 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 KPI84327.1 - 3.7e-14 53.1 0.0 1.1e-11 45.1 0.0 2.9 2 1 0 2 2 2 2 Peptidase M16 inactive domain CRF-BP PF05428.11 KPI84327.1 - 0.01 14.7 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Corticotropin-releasing factor binding protein (CRF-BP) Nop14 PF04147.12 KPI84327.1 - 5.1 5.2 5.1 7.3 4.7 5.1 1.1 1 0 0 1 1 1 0 Nop14-like family DnaJ PF00226.31 KPI84328.1 - 1.1e-16 60.7 0.0 1.9e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain ChaB PF06150.12 KPI84328.1 - 0.05 14.2 0.1 0.12 13.0 0.1 1.6 1 0 0 1 1 1 0 ChaB DUF3667 PF12412.8 KPI84328.1 - 0.052 13.1 0.6 0.093 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3667) Autophagy_act_C PF03987.15 KPI84329.1 - 0.0024 18.4 0.2 0.0059 17.2 0.2 1.7 1 1 0 1 1 1 1 Autophagocytosis associated protein, active-site domain MRF_C1 PF13887.6 KPI84330.1 - 0.072 12.3 0.1 0.072 12.3 0.1 2.8 3 0 0 3 3 3 0 Myelin gene regulatory factor -C-terminal domain 1 PEMT PF04191.13 KPI84331.1 - 1.6e-50 169.9 16.4 1.4e-29 102.5 0.7 2.9 3 0 0 3 3 3 2 Phospholipid methyltransferase ICMT PF04140.14 KPI84331.1 - 0.21 12.1 4.2 19 5.8 0.4 3.7 3 0 0 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family CPSase_L_D2 PF02786.17 KPI84332.1 - 1.9e-63 213.8 0.0 3.5e-63 212.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KPI84332.1 - 3.6e-44 149.8 0.4 2.2e-43 147.3 0.1 2.4 3 0 0 3 3 3 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KPI84332.1 - 1.6e-35 121.5 0.0 1.8e-34 118.1 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KPI84332.1 - 3.4e-14 52.4 0.5 8.6e-14 51.1 0.5 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KPI84332.1 - 7.9e-12 45.1 0.0 1.9e-11 43.9 0.0 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KPI84332.1 - 2.9e-11 43.2 0.0 5.6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KPI84332.1 - 1.6e-06 27.8 0.0 6.5e-06 25.9 0.0 2.0 1 1 1 2 2 2 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 KPI84332.1 - 0.00049 20.2 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 KPI84332.1 - 0.0093 15.4 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RnfC_N PF13375.6 KPI84332.1 - 0.015 15.3 0.0 0.64 10.0 0.0 2.6 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Ntox43 PF15537.6 KPI84332.1 - 0.018 15.1 0.0 0.049 13.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial toxin 43 ATPgrasp_ST PF14397.6 KPI84332.1 - 0.046 13.0 0.0 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp GARS_A PF01071.19 KPI84332.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 KPI84332.1 - 0.09 12.4 0.0 0.97 9.0 0.0 2.3 1 1 0 1 1 1 0 RimK-like ATP-grasp domain HlyD_2 PF12700.7 KPI84332.1 - 0.12 11.1 0.0 1.9 7.2 0.0 2.1 1 1 1 2 2 2 0 HlyD family secretion protein QRPTase_N PF02749.16 KPI84332.1 - 0.14 12.2 0.2 3.1 7.9 0.0 2.9 2 1 1 3 3 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain Robl_LC7 PF03259.17 KPI84334.1 - 0.00018 21.2 0.0 0.00031 20.5 0.0 1.4 1 1 0 1 1 1 1 Roadblock/LC7 domain DUF2384 PF09722.10 KPI84334.1 - 0.061 13.4 0.1 2.4 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) PQQ_2 PF13360.6 KPI84335.1 - 0.00065 19.4 0.1 0.34 10.4 0.1 2.9 2 1 0 2 2 2 1 PQQ-like domain UPF0184 PF03670.13 KPI84335.1 - 0.001 19.4 2.6 0.0042 17.4 2.6 2.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) PQQ PF01011.21 KPI84335.1 - 0.0013 18.6 0.1 8.1 6.6 0.0 4.0 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_3 PF13570.6 KPI84335.1 - 0.036 14.5 0.1 3.1 8.4 0.0 3.8 4 0 0 4 4 4 0 PQQ-like domain Elongin_A PF06881.11 KPI84335.1 - 0.48 11.0 3.3 2.1 8.9 0.4 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF4407 PF14362.6 KPI84335.1 - 4.9 6.4 15.2 0.67 9.3 6.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Pkinase PF00069.25 KPI84336.1 - 6.9e-62 209.2 0.0 9.2e-62 208.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84336.1 - 3.8e-42 144.4 0.0 5.6e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KPI84336.1 - 5.4e-14 52.6 0.1 1.1e-13 51.6 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KPI84336.1 - 1.4e-08 35.1 1.1 4.2e-07 30.3 1.1 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 KPI84336.1 - 8.7e-07 28.5 0.0 1.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI84336.1 - 0.0051 15.7 0.4 0.07 11.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase PH_11 PF15413.6 KPI84336.1 - 0.041 14.3 3.7 2.8 8.4 3.7 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 KPI84336.1 - 0.15 12.4 0.3 0.41 11.0 0.0 1.9 2 0 0 2 2 2 0 Plant pleckstrin homology-like region HEAT PF02985.22 KPI84337.1 - 5e-08 32.5 13.7 0.22 11.9 0.1 7.7 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 KPI84337.1 - 3.1e-05 24.3 11.5 0.0012 19.2 0.0 4.9 4 1 0 4 4 4 2 HEAT repeats Cnd1 PF12717.7 KPI84337.1 - 0.0031 17.6 0.0 0.34 10.9 0.0 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KPI84337.1 - 0.049 12.2 0.1 0.32 9.5 0.0 2.4 3 0 0 3 3 3 0 Adaptin N terminal region AAA PF00004.29 KPI84338.1 - 6.2e-26 91.4 0.0 1.1e-25 90.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI84338.1 - 4.1e-06 27.3 0.2 0.0001 22.8 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KPI84338.1 - 0.00033 20.9 0.1 0.0031 17.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI84338.1 - 0.00094 19.2 0.0 0.0029 17.6 0.0 1.9 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KPI84338.1 - 0.0026 18.1 0.0 0.0051 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 KPI84338.1 - 0.016 15.4 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KPI84338.1 - 0.022 14.7 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 KPI84338.1 - 0.026 15.1 0.0 0.044 14.3 0.0 1.3 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 KPI84338.1 - 0.03 14.2 0.0 0.14 12.1 0.0 2.0 1 1 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 KPI84338.1 - 0.033 13.8 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KPI84338.1 - 0.052 13.5 0.2 0.25 11.3 0.1 1.9 1 1 1 2 2 2 0 Rad17 P-loop domain IstB_IS21 PF01695.17 KPI84338.1 - 0.058 13.1 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 KPI84338.1 - 0.068 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain DUF815 PF05673.13 KPI84338.1 - 0.079 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 KPI84338.1 - 0.089 12.3 0.1 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_8 PF12780.7 KPI84338.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 AAA_28 PF13521.6 KPI84338.1 - 0.12 12.7 0.0 0.31 11.3 0.0 1.7 2 1 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 KPI84338.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.22 KPI84338.1 - 0.13 11.4 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 KPI84338.1 - 0.15 11.8 0.1 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytidylate_kin PF02224.18 KPI84338.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 KPI84339.1 - 0.00031 20.5 0.0 0.00045 20.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI84339.1 - 0.0022 18.4 1.9 0.007 16.8 0.2 2.0 1 1 1 2 2 2 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 KPI84339.1 - 0.012 15.0 0.1 0.024 14.0 0.0 1.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 KPI84339.1 - 0.025 14.3 0.3 0.031 14.0 0.3 1.1 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI84339.1 - 0.032 14.0 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KPI84339.1 - 0.073 13.3 0.2 0.12 12.7 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 KPI84339.1 - 0.096 13.1 0.0 0.17 12.3 0.0 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KPI84339.1 - 0.16 11.9 0.4 0.17 11.8 0.4 1.2 1 1 0 1 1 1 0 NACHT domain MRC1 PF09444.10 KPI84340.1 - 0.0082 16.7 1.5 0.0082 16.7 1.5 1.7 2 0 0 2 2 2 1 MRC1-like domain Fanconi_A_N PF15865.5 KPI84340.1 - 0.028 13.8 0.1 0.038 13.4 0.1 1.2 1 0 0 1 1 1 0 Fanconi anaemia group A protein N terminus Tai4 PF16695.5 KPI84340.1 - 0.035 14.6 0.9 0.073 13.6 0.0 2.0 2 1 0 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein RXT2_N PF08595.11 KPI84340.1 - 0.75 9.8 3.4 14 5.7 1.0 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal AvrM_N PF18247.1 KPI84341.1 - 0.12 12.4 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain PEX11 PF05648.14 KPI84342.1 - 8.1e-11 41.8 2.6 8.4e-06 25.4 0.1 2.1 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) PsbL PF02419.17 KPI84342.1 - 1.4 9.0 4.5 4.9 7.2 0.2 3.0 2 1 0 2 2 2 0 PsbL protein Ank_2 PF12796.7 KPI84343.1 - 1.3e-34 118.6 3.8 1.6e-15 57.4 0.5 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI84343.1 - 1.4e-33 114.8 4.7 6.9e-09 36.1 0.0 5.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI84343.1 - 5.3e-31 106.3 8.1 1.5e-10 41.1 0.1 5.1 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KPI84343.1 - 2e-27 94.4 5.4 1.6e-06 28.3 0.4 6.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 KPI84343.1 - 8.4e-26 87.2 4.7 0.001 19.4 0.1 6.5 6 0 0 6 6 6 6 Ankyrin repeat TPR_1 PF00515.28 KPI84343.1 - 3.3e-09 36.2 1.2 0.0051 16.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84343.1 - 2.1e-05 24.3 1.7 0.13 12.4 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI84343.1 - 0.00026 20.6 1.2 0.18 11.5 0.2 2.7 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 KPI84343.1 - 0.0067 16.7 1.9 1.3 9.5 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI84343.1 - 0.034 14.4 1.2 0.079 13.2 1.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.32 KPI84344.1 - 0.016 16.0 6.7 5.6 8.0 0.1 4.2 4 0 0 4 4 4 0 WD domain, G-beta repeat PARP_regulatory PF01358.18 KPI84345.1 - 1.2e-12 47.4 0.0 2.1e-12 46.6 0.0 1.3 1 1 0 1 1 1 1 Poly A polymerase regulatory subunit Enkurin PF13864.6 KPI84346.1 - 7.5e-19 68.0 3.4 1.1e-18 67.4 3.4 1.3 1 0 0 1 1 1 1 Calmodulin-binding SOAR PF16533.5 KPI84346.1 - 0.092 12.7 1.1 0.39 10.7 0.1 2.1 2 0 0 2 2 2 0 STIM1 Orai1-activating region FAD-SLDH PF12318.8 KPI84346.1 - 0.099 12.7 0.2 0.36 10.9 0.0 1.7 1 1 1 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF3592 PF12158.8 KPI84347.1 - 9.3e-09 35.5 0.2 1.2e-08 35.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3592) zf-RING_2 PF13639.6 KPI84348.1 - 6.3e-09 36.0 3.7 6.3e-09 36.0 3.7 5.0 5 1 0 5 5 4 1 Ring finger domain zf-RING_11 PF17123.5 KPI84348.1 - 3.1e-06 26.8 8.1 4.8e-06 26.2 4.1 2.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KPI84348.1 - 3.9e-06 26.8 1.1 3.9e-06 26.8 1.1 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KPI84348.1 - 2.7e-05 23.9 0.6 2.7e-05 23.9 0.6 4.1 6 1 0 6 6 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI84348.1 - 0.0015 18.3 2.0 0.0015 18.3 2.0 3.4 5 0 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 KPI84348.1 - 0.0023 18.1 1.2 0.0023 18.1 1.2 2.6 2 0 0 2 2 1 1 FANCL C-terminal domain zf-RING_5 PF14634.6 KPI84348.1 - 0.01 15.8 5.0 0.01 15.8 5.0 4.9 5 1 1 6 6 3 0 zinc-RING finger domain zf-rbx1 PF12678.7 KPI84348.1 - 0.017 15.4 4.2 0.017 15.4 4.2 3.5 3 1 0 3 3 3 0 RING-H2 zinc finger domain zf-CCCH_6 PF18585.1 KPI84348.1 - 0.026 14.4 0.3 0.074 12.9 0.3 1.8 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 FAM76 PF16046.5 KPI84348.1 - 0.23 10.8 5.1 0.43 9.9 5.1 1.4 1 0 0 1 1 1 0 FAM76 protein zf-ANAPC11 PF12861.7 KPI84348.1 - 2.2 8.4 10.3 1.3 9.1 4.2 3.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4865 PF16157.5 KPI84349.1 - 0.022 14.7 0.0 0.062 13.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4865) NTP_transferase PF00483.23 KPI84351.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.4 1 1 0 1 1 1 0 Nucleotidyl transferase Ribosomal_L22 PF00237.19 KPI84352.1 - 4e-31 107.3 0.3 5e-31 107.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e ANTH PF07651.16 KPI84353.1 - 6.3e-27 94.3 1.1 1.1e-26 93.4 1.1 1.4 1 1 0 1 1 1 1 ANTH domain ENTH PF01417.20 KPI84353.1 - 0.0077 16.3 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 ENTH domain BCDHK_Adom3 PF10436.9 KPI84354.1 - 9.8e-22 77.5 0.1 1.9e-21 76.6 0.0 1.4 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DASH_Dam1 PF08653.10 KPI84354.1 - 0.067 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 DASH complex subunit Dam1 Carboxyl_trans PF01039.22 KPI84355.1 - 3.5e-126 421.8 0.0 5.4e-126 421.1 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 KPI84355.1 - 1.2e-52 179.1 0.0 1.1e-51 176.0 0.1 2.3 2 1 0 2 2 2 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 KPI84355.1 - 1.3e-49 168.6 0.1 2.9e-49 167.4 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KPI84355.1 - 4.7e-29 101.1 0.0 1.8e-28 99.3 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KPI84355.1 - 4.7e-22 78.1 0.0 8.8e-21 74.0 0.0 2.8 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KPI84355.1 - 4.4e-07 29.6 0.0 1.4e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KPI84355.1 - 0.00021 20.9 0.0 0.0005 19.7 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KPI84355.1 - 0.00041 20.0 0.1 0.001 18.7 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KPI84355.1 - 0.008 16.2 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain SMK-1 PF04802.15 KPI84356.1 - 3e-07 30.5 0.0 5.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 XylR_N PF06505.11 KPI84357.1 - 0.0063 16.2 2.6 0.029 14.1 2.6 2.3 1 0 0 1 1 1 1 Activator of aromatic catabolism MIS13 PF08202.11 KPI84358.1 - 0.083 12.2 8.5 0.1 11.8 2.6 2.5 1 1 1 2 2 2 0 Mis12-Mtw1 protein family HWE_HK PF07536.14 KPI84359.1 - 0.028 15.1 3.7 0.028 15.1 3.7 2.2 2 1 0 2 2 2 0 HWE histidine kinase Bacillus_HBL PF05791.11 KPI84359.1 - 0.12 12.2 4.9 0.047 13.5 1.3 1.9 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Fmp27_WPPW PF10359.9 KPI84359.1 - 0.18 10.6 6.5 0.23 10.3 6.1 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GIT_CC PF16559.5 KPI84359.1 - 0.3 11.0 10.2 17 5.3 0.9 3.4 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor CENP-H PF05837.12 KPI84359.1 - 0.92 9.9 18.0 0.029 14.8 8.7 2.6 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 KPI84359.1 - 0.94 9.5 9.9 0.35 10.9 3.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 KPI84359.1 - 1.5 9.0 8.4 0.29 11.3 1.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.8 KPI84359.1 - 1.7 6.1 23.4 1.9 5.9 23.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CLZ PF16526.5 KPI84359.1 - 2.7 8.4 15.8 1.5 9.3 1.6 3.7 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TPR_MLP1_2 PF07926.12 KPI84359.1 - 3.5 7.7 27.7 0.093 12.8 14.8 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FUSC PF04632.12 KPI84359.1 - 5.1 5.5 24.3 7.2 5.0 24.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Adap_comp_sub PF00928.21 KPI84362.1 - 1e-39 136.6 0.0 1.3e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KPI84362.1 - 2.3e-06 27.6 0.1 4.2e-06 26.8 0.1 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Mon1 PF03164.14 KPI84362.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Trafficking protein Mon1 OGFr_N PF04664.13 KPI84363.1 - 1.8e-28 99.5 0.0 1.3e-19 70.6 0.0 2.2 2 0 0 2 2 2 2 Opioid growth factor receptor (OGFr) conserved region BolA PF01722.18 KPI84364.1 - 3.1e-14 53.0 0.0 3.6e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein adh_short_C2 PF13561.6 KPI84365.1 - 3.9e-44 151.0 0.3 5e-44 150.6 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KPI84365.1 - 5.8e-43 146.6 0.8 7.6e-43 146.3 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KPI84365.1 - 2.5e-09 37.3 3.3 1e-08 35.3 3.3 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI84365.1 - 1.6e-06 27.8 0.4 6.4e-06 25.8 0.5 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KPI84365.1 - 0.0027 17.6 2.3 0.0044 16.9 2.3 1.3 1 0 0 1 1 1 1 NAD(P)H-binding HI0933_like PF03486.14 KPI84365.1 - 0.0029 16.3 0.3 0.0041 15.9 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 KPI84365.1 - 0.004 16.5 0.5 0.007 15.7 0.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NmrA PF05368.13 KPI84365.1 - 0.011 15.3 2.0 0.018 14.6 2.0 1.2 1 0 0 1 1 1 0 NmrA-like family Shikimate_DH PF01488.20 KPI84365.1 - 0.037 14.1 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 KPI84365.1 - 0.052 13.1 0.1 0.083 12.5 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KPI84365.1 - 0.053 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Sacchrp_dh_NADP PF03435.18 KPI84365.1 - 0.058 13.6 1.1 0.1 12.9 0.9 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 KPI84365.1 - 0.15 11.9 0.5 0.25 11.2 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 KPI84365.1 - 0.15 11.4 0.1 0.66 9.3 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase TFCD_C PF12612.8 KPI84366.1 - 2.7e-27 95.8 0.6 1e-26 93.9 0.6 2.1 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 KPI84366.1 - 2.9e-07 30.8 14.2 0.12 12.8 0.1 7.5 7 1 0 8 8 8 2 HEAT repeats Cnd1 PF12717.7 KPI84366.1 - 0.0024 17.9 0.9 1.1 9.3 0.1 4.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KPI84366.1 - 1.1 9.7 36.2 1.3 9.5 0.0 10.9 11 1 1 12 12 12 0 HEAT repeat Ribosomal_60s PF00428.19 KPI84366.1 - 3.7 8.2 14.2 0.024 15.2 2.1 3.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein PI3_PI4_kinase PF00454.27 KPI84367.1 - 6.7e-44 150.6 0.0 2.6e-28 99.5 0.0 2.6 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KPI84367.1 - 7.4e-23 80.9 0.0 1.9e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 KPI84367.1 - 0.00014 21.8 0.0 0.0003 20.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 KPI84367.1 - 0.063 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PCIF1_WW PF12237.8 KPI84368.1 - 2.6e-12 46.7 0.0 4.8e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain STOP PF05217.12 KPI84370.1 - 0.011 16.0 9.4 0.013 15.8 7.4 2.3 2 1 0 2 2 2 0 STOP protein KIP1 PF07765.12 KPI84371.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 KIP1-like protein GAS PF13851.6 KPI84372.1 - 0.0084 15.5 5.7 0.0084 15.5 5.7 3.7 2 2 1 3 3 3 1 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 KPI84372.1 - 0.17 9.3 40.0 0.13 9.8 12.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 KPI84372.1 - 1 9.4 42.2 0.14 12.2 15.3 3.5 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG2 PF06148.11 KPI84372.1 - 2.1 8.5 19.1 0.64 10.1 2.0 3.8 2 2 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 FPP PF05911.11 KPI84372.1 - 2.6 6.1 29.9 0.047 11.9 10.4 2.7 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil Laminin_II PF06009.12 KPI84372.1 - 3.5 7.7 18.7 2.3 8.2 2.6 3.6 2 1 1 3 3 3 0 Laminin Domain II Myosin_tail_1 PF01576.19 KPI84372.1 - 4 5.1 48.4 0.014 13.3 16.3 2.3 2 1 0 2 2 2 0 Myosin tail DUF1664 PF07889.12 KPI84372.1 - 6.8 6.8 19.0 1.9 8.5 1.7 3.6 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 KPI84372.1 - 9.3 4.7 18.8 2.1 6.9 5.1 2.3 2 0 0 2 2 2 0 AAA domain Ins134_P3_kin PF05770.11 KPI84375.1 - 0.0034 16.9 0.0 0.059 12.9 0.0 2.7 3 0 0 3 3 3 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain DUF4574 PF15141.6 KPI84376.1 - 0.064 13.2 1.2 0.21 11.5 0.4 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 CEP63 PF17045.5 KPI84376.1 - 0.54 10.1 23.4 2 8.2 5.6 2.5 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa SOAR PF16533.5 KPI84376.1 - 2.8 7.9 9.8 3.6 7.6 1.1 3.2 2 1 0 2 2 2 0 STIM1 Orai1-activating region UPF0242 PF06785.11 KPI84376.1 - 8.8 6.4 19.7 3 7.9 6.4 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CASP_C PF08172.12 KPI84376.1 - 9.6 5.5 18.7 0.22 10.8 1.5 3.0 3 1 1 4 4 4 0 CASP C terminal Telomere_reg-2 PF10193.9 KPI84377.1 - 0.00027 21.4 0.0 0.0014 19.0 0.0 2.3 2 0 0 2 2 2 1 Telomere length regulation protein Leg1 PF05612.12 KPI84378.1 - 0.027 13.6 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 Leg1 TPR_MLP1_2 PF07926.12 KPI84378.1 - 0.5 10.4 15.2 0.17 12.0 3.6 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Rotamase PF00639.21 KPI84378.1 - 1.2 10.2 6.7 0.56 11.2 0.2 3.3 2 1 1 3 3 3 0 PPIC-type PPIASE domain COX6B PF02297.17 KPI84379.1 - 0.038 14.2 0.1 1.6 9.0 0.1 2.2 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIb F-box-like PF12937.7 KPI84381.1 - 0.018 14.9 1.9 0.04 13.8 1.9 1.6 1 0 0 1 1 1 0 F-box-like RSB_motif PF16294.5 KPI84384.1 - 0.18 12.1 3.6 0.32 11.3 3.6 1.3 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif PSP1 PF04468.12 KPI84385.1 - 1.2e-23 83.1 0.3 2.2e-23 82.3 0.3 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Cupin_8 PF13621.6 KPI84386.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Cupin-like domain Aldose_epim PF01263.20 KPI84387.1 - 2e-37 129.1 0.0 2.3e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Aldose_epim PF01263.20 KPI84388.1 - 5.9e-29 101.3 0.6 7.1e-29 101.1 0.6 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase TPR_19 PF14559.6 KPI84389.1 - 2.3e-33 114.5 56.8 6.2e-08 33.0 0.0 15.0 13 4 1 15 15 14 8 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84389.1 - 9.8e-28 94.0 32.8 0.0044 17.0 0.0 18.0 20 0 0 20 20 20 4 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84389.1 - 2.1e-22 77.9 17.7 0.0006 19.5 0.0 11.6 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 KPI84389.1 - 4.9e-21 75.1 45.8 4.9e-06 27.1 0.7 11.7 9 3 3 12 12 11 5 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84389.1 - 1.5e-17 62.8 73.8 0.09 13.6 0.2 19.5 12 6 8 20 20 20 6 Tetratricopeptide repeat TPR_8 PF13181.6 KPI84389.1 - 1.5e-15 56.0 29.6 0.00047 20.2 0.2 13.1 15 0 0 15 15 13 5 Tetratricopeptide repeat TPR_7 PF13176.6 KPI84389.1 - 6.2e-15 54.1 21.5 0.021 14.8 0.2 11.2 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 KPI84389.1 - 1.3e-09 37.6 14.6 0.21 11.3 0.0 10.2 10 1 0 10 10 10 3 TPR repeat TPR_12 PF13424.6 KPI84389.1 - 8.2e-08 32.4 72.5 0.0037 17.5 0.2 14.6 13 5 4 17 17 15 5 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KPI84389.1 - 5.6e-07 29.2 19.3 0.029 14.0 0.9 7.1 6 1 1 7 7 7 3 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 KPI84389.1 - 6e-07 29.7 56.7 1 10.1 0.7 16.3 20 0 0 20 20 17 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI84389.1 - 6.6e-07 29.5 35.7 0.011 15.9 0.2 9.6 10 3 1 11 11 10 3 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 KPI84389.1 - 4.6e-05 22.5 5.8 0.52 9.2 0.1 5.2 5 2 1 6 6 6 3 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 KPI84389.1 - 0.0019 18.0 31.2 0.063 13.2 0.2 10.3 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KPI84389.1 - 0.0025 17.9 39.2 0.013 15.6 0.6 8.4 8 2 2 10 10 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 KPI84389.1 - 0.0033 17.7 13.7 1.1e+02 3.6 0.0 10.1 12 0 0 12 12 11 0 Tetratricopeptide repeat SNAP PF14938.6 KPI84389.1 - 0.038 13.4 20.6 1.1 8.6 7.6 6.4 5 1 1 6 6 6 0 Soluble NSF attachment protein, SNAP PPR PF01535.20 KPI84389.1 - 0.066 13.5 0.1 6.8 7.2 0.0 4.6 5 0 0 5 5 2 0 PPR repeat TPR_4 PF07721.14 KPI84389.1 - 0.086 13.5 0.1 0.086 13.5 0.1 12.2 13 0 0 13 13 10 0 Tetratricopeptide repeat MIT PF04212.18 KPI84389.1 - 2.5 8.2 7.5 9.9 6.3 0.1 4.9 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain EF-hand_7 PF13499.6 KPI84390.1 - 2.1e-08 34.5 0.6 0.00037 20.9 0.1 3.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI84390.1 - 2e-07 30.4 0.0 0.22 11.6 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 KPI84390.1 - 5.9e-06 25.5 0.0 1.5 8.5 0.0 4.3 4 0 0 4 4 4 1 EF hand zf-RING_UBOX PF13445.6 KPI84390.1 - 6e-06 26.2 2.0 6e-06 26.2 2.0 2.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KPI84390.1 - 7.6e-06 25.7 6.3 7.6e-06 25.7 6.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI84390.1 - 2.2e-05 24.5 6.9 2.2e-05 24.5 6.9 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 KPI84390.1 - 0.00017 21.4 7.3 0.00017 21.4 7.3 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI84390.1 - 0.00042 20.6 8.3 0.00042 20.6 8.3 2.7 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 KPI84390.1 - 0.0012 18.7 5.9 0.0012 18.7 5.9 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI84390.1 - 0.0048 16.7 7.2 0.0048 16.7 7.2 2.8 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 EF-hand_8 PF13833.6 KPI84390.1 - 0.0077 16.1 0.3 0.36 10.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair zf-RING_5 PF14634.6 KPI84390.1 - 0.0081 16.1 5.0 0.0081 16.1 5.0 2.6 2 2 1 3 3 2 1 zinc-RING finger domain zf-C2H2_4 PF13894.6 KPI84390.1 - 0.012 16.4 14.3 0.24 12.3 0.1 4.9 5 0 0 5 5 4 0 C2H2-type zinc finger TFIIS_C PF01096.18 KPI84390.1 - 0.1 12.4 0.1 0.1 12.4 0.1 3.3 4 0 0 4 4 3 0 Transcription factor S-II (TFIIS) zf-RING_6 PF14835.6 KPI84390.1 - 0.12 12.2 3.7 0.42 10.5 3.7 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-4CXXC_R1 PF10497.9 KPI84390.1 - 0.37 11.0 9.3 12 6.1 5.5 2.8 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 PHD PF00628.29 KPI84390.1 - 2 8.4 11.7 0.54 10.2 5.0 2.7 2 0 0 2 2 2 0 PHD-finger Elf1 PF05129.13 KPI84390.1 - 2.3 8.3 8.8 2.4 8.2 2.3 2.6 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.6 KPI84390.1 - 6.6 6.9 6.2 2.9 8.0 0.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger TBCC PF07986.12 KPI84391.1 - 5e-18 65.0 0.0 7.7e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Ank_4 PF13637.6 KPI84393.1 - 1.7e-16 60.3 4.6 3.1e-06 27.6 0.0 5.9 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI84393.1 - 8.5e-16 57.8 6.2 7.5e-09 35.7 0.1 5.3 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI84393.1 - 2.2e-15 57.0 2.1 6.7e-08 33.0 0.0 4.1 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI84393.1 - 9.5e-14 50.2 5.7 0.0023 18.3 0.0 6.8 6 0 0 6 6 6 2 Ankyrin repeat DHHC PF01529.20 KPI84393.1 - 5.7e-11 42.7 0.4 5.7e-11 42.7 0.4 2.5 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ank PF00023.30 KPI84393.1 - 4.9e-10 39.4 14.2 0.0033 17.8 0.1 5.8 4 1 0 4 4 4 2 Ankyrin repeat NTP_transf_2 PF01909.23 KPI84394.1 - 4e-06 27.0 0.0 1.1e-05 25.7 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 KPI84394.1 - 0.00015 21.9 0.1 0.00038 20.6 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 KPI84394.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase DUF2423 PF10338.9 KPI84395.1 - 0.00038 20.6 4.0 0.00038 20.6 4.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) Arf PF00025.21 KPI84396.1 - 2.8e-60 202.7 0.0 3.2e-60 202.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI84396.1 - 8e-15 55.1 0.0 1.1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI84396.1 - 1.3e-13 50.8 0.0 1.5e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KPI84396.1 - 1e-11 44.7 0.0 1.3e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KPI84396.1 - 8.1e-11 41.7 0.3 5.3e-08 32.4 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KPI84396.1 - 9.1e-06 25.2 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI84396.1 - 0.00021 21.3 0.0 0.00039 20.5 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KPI84396.1 - 0.00061 19.2 0.0 0.00078 18.8 0.0 1.3 1 1 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.27 KPI84396.1 - 0.014 14.9 0.0 3 7.3 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain NTPase_1 PF03266.15 KPI84396.1 - 0.096 12.6 0.1 0.16 11.9 0.1 1.5 1 1 0 1 1 1 0 NTPase AAA_33 PF13671.6 KPI84396.1 - 0.19 11.9 0.1 0.31 11.2 0.1 1.5 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KPI84396.1 - 0.21 11.4 0.0 0.94 9.2 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 KPI84396.1 - 0.69 9.5 2.0 3.3 7.3 0.0 2.2 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain 14-3-3 PF00244.20 KPI84397.1 - 2.8e-84 282.1 3.9 3.2e-84 281.9 3.9 1.0 1 0 0 1 1 1 1 14-3-3 protein RE_XcyI PF09571.10 KPI84397.1 - 0.058 12.6 0.0 0.085 12.1 0.0 1.2 1 0 0 1 1 1 0 XcyI restriction endonuclease PIF1 PF05970.14 KPI84399.1 - 1.9e-34 119.4 2.3 3.2e-27 95.7 0.1 3.8 3 1 1 4 4 4 3 PIF1-like helicase AAA_30 PF13604.6 KPI84399.1 - 5.5e-18 65.4 0.3 3.4e-17 62.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KPI84399.1 - 2.9e-06 27.7 0.0 1.4e-05 25.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KPI84399.1 - 0.0004 20.2 0.0 0.37 10.5 0.0 3.1 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KPI84399.1 - 0.0006 20.1 0.3 0.12 12.7 0.2 2.8 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KPI84399.1 - 0.0017 17.7 0.3 0.0045 16.4 0.3 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KPI84399.1 - 0.0026 18.2 0.0 0.011 16.2 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KPI84399.1 - 0.004 17.2 0.1 0.018 15.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 KPI84399.1 - 0.0041 17.0 2.2 0.034 13.9 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA PF00004.29 KPI84399.1 - 0.006 17.0 0.0 0.017 15.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Herpes_Helicase PF02689.14 KPI84399.1 - 0.015 13.3 0.2 0.31 8.9 0.0 2.3 2 0 0 2 2 2 0 Helicase DUF853 PF05872.12 KPI84399.1 - 0.018 13.6 0.2 0.04 12.5 0.2 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) UvrD_C_2 PF13538.6 KPI84399.1 - 0.019 14.8 0.4 0.11 12.3 0.4 2.2 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain RBR PF17208.3 KPI84399.1 - 0.028 15.1 0.6 0.1 13.3 0.6 2.0 1 0 0 1 1 1 0 RNA binding Region NACHT PF05729.12 KPI84399.1 - 0.03 14.3 0.1 0.17 11.8 0.1 2.2 2 0 0 2 2 2 0 NACHT domain CbiA PF01656.23 KPI84399.1 - 0.064 13.3 0.3 0.21 11.7 0.3 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PhoH PF02562.16 KPI84399.1 - 0.067 12.6 1.5 0.16 11.4 0.0 2.4 3 0 0 3 3 3 0 PhoH-like protein Invasin_D3 PF09134.10 KPI84399.1 - 0.46 10.8 5.9 1.3 9.4 0.7 2.8 2 0 0 2 2 2 0 Invasin, domain 3 PIF1 PF05970.14 KPI84400.1 - 1.7e-34 119.6 0.1 2e-26 93.0 0.1 3.3 3 0 0 3 3 3 3 PIF1-like helicase AAA_30 PF13604.6 KPI84400.1 - 3.1e-22 79.2 1.9 4.4e-22 78.7 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KPI84400.1 - 8.4e-07 29.4 3.6 1e-05 25.9 0.3 3.1 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 KPI84400.1 - 0.0031 17.8 4.0 2.2 8.6 0.0 3.5 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 KPI84400.1 - 0.0082 15.9 0.6 3.6 7.2 0.0 3.2 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF853 PF05872.12 KPI84400.1 - 0.0092 14.6 1.3 0.02 13.5 1.3 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) Herpes_Helicase PF02689.14 KPI84400.1 - 0.022 12.7 0.4 3.6 5.4 0.0 2.4 2 0 0 2 2 2 0 Helicase UvrD_C_2 PF13538.6 KPI84400.1 - 0.056 13.3 0.4 0.33 10.8 0.4 2.3 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 KPI84400.1 - 0.075 13.4 1.7 0.25 11.7 0.2 2.7 2 0 0 2 2 2 0 AAA ATPase domain PhoH PF02562.16 KPI84400.1 - 0.092 12.2 0.1 0.18 11.2 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 KPI84400.1 - 0.17 12.4 0.5 0.7 10.4 0.5 2.0 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.6 KPI84400.1 - 6.2 6.5 9.7 1.3 8.8 0.1 3.4 4 1 1 5 5 5 0 AAA domain Macoilin PF09726.9 KPI84401.1 - 2.5 6.6 8.3 4.7 5.6 8.3 1.4 1 0 0 1 1 1 0 Macoilin family Sec20 PF03908.13 KPI84402.1 - 5.5e-11 42.2 1.0 1.1e-10 41.2 1.0 1.5 1 0 0 1 1 1 1 Sec20 HsbA PF12296.8 KPI84402.1 - 0.0029 18.0 0.1 0.011 16.1 0.0 2.0 2 0 0 2 2 2 1 Hydrophobic surface binding protein A ALIX_LYPXL_bnd PF13949.6 KPI84402.1 - 0.0084 15.4 0.3 0.16 11.3 0.0 2.2 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV DFF-C PF09033.10 KPI84402.1 - 0.2 11.5 2.7 11 5.9 0.5 2.4 2 1 0 2 2 2 0 DNA Fragmentation factor 45kDa, C terminal domain PHC2_SAM_assoc PF16616.5 KPI84403.1 - 0.00047 21.0 1.1 0.00047 21.0 1.1 3.2 3 1 0 4 4 4 1 Unstructured region on Polyhomeotic-like protein 1 and 2 DUF641 PF04859.12 KPI84403.1 - 0.029 14.7 0.2 0.093 13.1 0.1 1.9 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 KPI84403.1 - 0.051 14.2 0.4 0.16 12.6 0.4 1.9 1 0 0 1 1 1 0 SlyX Ada3 PF10198.9 KPI84403.1 - 0.11 12.6 1.8 0.26 11.5 1.5 1.7 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 DUF5335 PF17269.2 KPI84403.1 - 0.16 11.8 2.0 0.69 9.8 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5335) FAD_binding_6 PF00970.24 KPI84405.1 - 3.8e-09 36.8 0.0 7e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KPI84405.1 - 0.038 14.6 0.0 0.72 10.5 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain zf-CHY PF05495.12 KPI84406.1 - 0.015 15.8 4.1 0.84 10.2 0.7 2.2 2 0 0 2 2 2 0 CHY zinc finger zf-MIZ PF02891.20 KPI84406.1 - 0.041 13.6 6.5 1.9 8.3 0.4 2.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Cytochrome_CBB3 PF13442.6 KPI84406.1 - 0.062 13.6 4.9 4.4 7.7 0.5 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Gin PF10764.9 KPI84406.1 - 0.14 12.1 1.0 17 5.5 0.1 2.6 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin Stc1 PF12898.7 KPI84406.1 - 0.25 11.9 6.8 3 8.5 0.2 2.5 2 0 0 2 2 2 0 Stc1 domain Cytochrome_C7 PF14522.6 KPI84406.1 - 0.28 11.2 4.2 11 6.1 0.1 2.5 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c zf-C2H2_6 PF13912.6 KPI84406.1 - 0.28 11.2 4.0 8.9 6.4 0.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger CxC4 PF18717.1 KPI84406.1 - 1.3 8.8 4.2 13 5.6 0.2 2.5 2 1 0 2 2 2 0 CxC4 like cysteine cluster associated with KDZ transposases zf-LSD1 PF06943.12 KPI84406.1 - 1.5 8.7 4.8 19 5.2 0.3 2.6 2 0 0 2 2 2 0 LSD1 zinc finger zf-H2C2_2 PF13465.6 KPI84406.1 - 5.7 7.5 6.8 2.1e+02 2.6 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger double domain Gar1 PF04410.14 KPI84407.1 - 3.5e-21 75.6 0.0 5.7e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Cohesin_HEAT PF12765.7 KPI84407.1 - 1.2 9.5 3.5 1 9.8 0.8 2.4 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion cNMP_binding PF00027.29 KPI84408.1 - 2.5e-20 72.3 0.0 7.6e-08 32.3 0.0 4.2 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Bcl-2 PF00452.19 KPI84408.1 - 0.14 12.9 0.2 1.8 9.3 0.1 2.7 3 0 0 3 3 3 0 Apoptosis regulator proteins, Bcl-2 family Glyco_hydro_42C PF08533.10 KPI84409.1 - 0.0021 17.7 0.0 0.0037 16.9 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain DUF761 PF05553.11 KPI84409.1 - 0.037 13.5 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Cotton fibre expressed protein PIN_4 PF13638.6 KPI84411.1 - 8e-06 26.2 0.0 4.2e-05 23.8 0.0 2.2 1 1 0 1 1 1 1 PIN domain HECT PF00632.25 KPI84412.1 - 6.8e-37 127.6 0.0 1.3e-36 126.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 KPI84412.1 - 1e-26 93.4 0.0 6.7e-07 29.4 0.0 4.8 4 0 0 4 4 4 4 SPRY domain ZZ PF00569.17 KPI84412.1 - 0.0079 16.0 14.5 0.019 14.7 14.5 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type zf-UBR PF02207.20 KPI84412.1 - 1.3 9.3 16.9 0.054 13.7 9.3 2.6 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) ERCC3_RAD25_C PF16203.5 KPI84413.1 - 8e-72 241.4 0.0 1.3e-71 240.7 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 KPI84413.1 - 1.5e-18 67.1 0.1 3.7e-18 65.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI84413.1 - 1.7e-13 51.0 0.0 3.4e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI84413.1 - 1.1e-11 45.0 0.1 2.3e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KPI84413.1 - 1.3e-06 27.4 0.0 2.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain COPIIcoated_ERV PF07970.12 KPI84414.1 - 1.6e-39 136.1 0.2 2e-39 135.7 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KPI84414.1 - 2.6e-25 88.6 0.2 2.6e-25 88.6 0.2 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Ax_dynein_light PF10211.9 KPI84416.1 - 5.2e-47 160.2 6.2 7.6e-47 159.7 6.2 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain Tubulin PF00091.25 KPI84417.1 - 5e-63 212.9 0.0 6.8e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KPI84417.1 - 2.1e-21 76.4 0.0 3.5e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 KPI84417.1 - 1.5e-05 24.4 0.0 2.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 KPI84417.1 - 0.021 14.5 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Bombesin PF02044.17 KPI84417.1 - 0.17 12.0 1.2 0.35 11.0 1.2 1.5 1 0 0 1 1 1 0 Bombesin-like peptide Blt1 PF12754.7 KPI84418.1 - 0.051 13.9 0.0 0.2 12.0 0.0 2.0 1 0 0 1 1 1 0 Blt1 N-terminal domain Clathrin PF00637.20 KPI84420.1 - 4.8e-12 46.0 22.5 0.005 16.7 0.1 9.7 5 4 2 9 9 9 3 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 KPI84420.1 - 1.9e-08 34.5 0.0 0.011 16.0 0.0 4.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI84420.1 - 2.8e-08 34.3 1.9 1.1 10.3 0.0 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat PPR PF01535.20 KPI84420.1 - 1.7e-05 24.7 4.6 2.9 8.3 0.1 7.2 5 1 1 6 6 6 1 PPR repeat TPR_4 PF07721.14 KPI84420.1 - 2.7e-05 24.4 0.5 5.9 7.8 0.0 6.0 6 0 0 6 6 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI84420.1 - 0.00059 19.7 23.9 0.83 9.8 0.0 11.2 11 3 0 11 11 11 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84420.1 - 0.0012 18.6 37.9 1.2 9.0 0.1 10.8 9 1 0 9 9 9 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 KPI84420.1 - 0.019 14.0 6.5 0.22 10.5 0.1 4.3 3 2 2 5 5 5 0 Coatomer WD associated region ANAPC3 PF12895.7 KPI84420.1 - 0.031 14.5 0.2 0.031 14.5 0.2 6.1 7 2 2 9 9 9 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KPI84420.1 - 0.04 14.0 0.1 0.04 14.0 0.1 11.7 11 1 1 12 12 12 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84420.1 - 0.099 12.9 0.1 0.099 12.9 0.1 10.0 11 0 0 11 11 11 0 Tetratricopeptide repeat PTAC PF06130.12 KPI84420.1 - 0.11 12.6 0.0 0.35 11.1 0.0 1.8 1 0 0 1 1 1 0 Phosphate propanoyltransferase TPR_14 PF13428.6 KPI84420.1 - 0.22 12.4 35.1 10 7.2 0.0 13.5 12 4 2 15 15 14 0 Tetratricopeptide repeat PPR_2 PF13041.6 KPI84420.1 - 1.3 9.3 7.0 3.7 7.8 0.1 4.9 6 0 0 6 6 5 0 PPR repeat family Utp13 PF08625.11 KPI84420.1 - 1.7 8.5 6.7 3.8 7.4 0.1 4.3 4 1 0 4 4 4 0 Utp13 specific WD40 associated domain Clathrin_H_link PF13838.6 KPI84420.1 - 2.5 8.1 8.5 1.7 8.6 0.0 4.4 5 0 0 5 5 5 0 Clathrin-H-link TPR_10 PF13374.6 KPI84420.1 - 8.7 6.4 12.6 2.7 8.0 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat PDCD2_C PF04194.13 KPI84423.1 - 2.8e-27 95.9 0.7 2.8e-27 95.9 0.7 2.3 2 1 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain CytB6-F_Fe-S PF08802.10 KPI84424.1 - 0.061 13.4 0.1 0.25 11.4 0.1 2.1 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit TetR_C_21 PF17926.1 KPI84424.1 - 0.066 13.3 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain GDH_N PF12466.8 KPI84424.1 - 0.19 11.9 1.7 2 8.7 0.1 3.0 3 1 0 3 3 3 0 Glutamate dehydrogenase N terminal Methyltransf_21 PF05050.12 KPI84425.1 - 1.3e-09 38.3 0.1 5.5e-09 36.3 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.6 KPI84425.1 - 0.0088 15.6 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI84425.1 - 0.047 13.2 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 KPI84425.1 - 0.067 12.1 0.1 0.75 8.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) PspB PF06667.12 KPI84425.1 - 0.22 11.6 1.1 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 Phage shock protein B FBPase PF00316.20 KPI84426.1 - 7.5e-59 198.4 0.0 9.6e-59 198.0 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain NdhM PF10664.9 KPI84426.1 - 0.061 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M SCO1-SenC PF02630.14 KPI84429.1 - 9.2e-46 155.1 0.0 1.3e-45 154.6 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 KPI84429.1 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 KPI84429.1 - 0.11 12.9 0.0 0.2 12.0 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like E1-E2_ATPase PF00122.20 KPI84431.1 - 8.9e-23 80.7 0.0 8.9e-23 80.7 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KPI84431.1 - 6.2e-16 59.3 0.9 7.4e-08 32.9 0.1 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase CALCOCO1 PF07888.11 KPI84433.1 - 0.0027 16.6 40.4 0.0027 16.6 40.4 4.6 3 2 2 5 5 5 2 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_DNA_bd PF12329.8 KPI84433.1 - 0.0041 17.1 2.8 0.0041 17.1 2.8 8.0 5 3 5 10 10 10 2 TATA element modulatory factor 1 DNA binding Tcf25 PF04910.14 KPI84434.1 - 3.9e-38 131.4 0.0 6.3e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 CDC27 PF09507.10 KPI84434.1 - 0.55 9.6 33.4 0.89 8.9 33.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Acyltransferase PF01553.21 KPI84437.1 - 2.5e-13 49.8 0.2 5.5e-13 48.7 0.1 1.6 2 0 0 2 2 2 1 Acyltransferase Acyltransferase PF01553.21 KPI84438.1 - 8.6e-12 44.8 0.0 1.5e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DUF2761 PF10959.8 KPI84438.1 - 0.017 15.1 0.0 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2761) COPI_assoc PF08507.10 KPI84439.1 - 2.1e-10 40.8 9.7 3.3e-10 40.1 9.7 1.2 1 0 0 1 1 1 1 COPI associated protein DUF4064 PF13273.6 KPI84439.1 - 0.16 12.3 0.0 0.16 12.3 0.0 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF4064) DUF1129 PF06570.11 KPI84439.1 - 0.18 11.2 3.8 0.65 9.4 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF2070 PF09843.9 KPI84439.1 - 8.2 4.6 12.3 12 4.1 12.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Aminotran_1_2 PF00155.21 KPI84440.1 - 1.9e-61 208.3 0.0 2.2e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KPI84440.1 - 0.036 12.6 0.0 0.058 11.9 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF2325 PF10087.9 KPI84440.1 - 0.16 12.1 0.1 15 5.8 0.0 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) Aminotran_1_2 PF00155.21 KPI84441.1 - 1.2e-60 205.7 0.0 1.3e-60 205.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KPI84441.1 - 0.00011 20.9 0.0 0.00016 20.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KPI84441.1 - 0.0041 16.1 0.0 0.007 15.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KPI84441.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KPI84441.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 KPI84442.1 - 3.6e-60 204.1 0.0 4.1e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KPI84442.1 - 0.00022 19.9 0.0 0.00038 19.1 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KPI84442.1 - 0.00032 19.8 0.0 0.00049 19.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KPI84442.1 - 0.0022 17.3 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KPI84443.1 - 2.6e-61 207.8 0.0 3e-61 207.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II UPF0561 PF10573.9 KPI84444.1 - 0.11 12.7 4.2 0.12 12.5 3.8 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0561 DUF4813 PF16072.5 KPI84444.1 - 0.15 11.7 10.1 0.22 11.2 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Sterol_MT_C PF08498.10 KPI84447.1 - 9.9e-23 80.2 0.1 2.6e-22 78.9 0.1 1.7 2 0 0 2 2 2 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 KPI84447.1 - 9.7e-19 67.8 0.3 7.4e-18 65.0 0.1 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84447.1 - 1.1e-14 54.9 0.2 4.4e-14 52.9 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI84447.1 - 1.4e-12 47.7 0.0 3.8e-12 46.3 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI84447.1 - 3.5e-09 36.3 0.0 8e-09 35.2 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KPI84447.1 - 1.9e-08 34.0 0.1 2.8e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KPI84447.1 - 8.2e-08 32.2 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84447.1 - 1.9e-07 31.7 0.1 2.6e-06 28.1 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 KPI84447.1 - 0.025 14.1 0.0 0.24 10.9 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.6 KPI84447.1 - 0.15 12.1 0.2 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain EF-hand_7 PF13499.6 KPI84448.1 - 4.2e-06 27.1 0.0 6.9e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI84448.1 - 5.6e-05 22.8 0.0 0.32 11.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KPI84448.1 - 0.00013 21.3 0.0 0.71 9.6 0.0 2.4 2 0 0 2 2 2 2 EF hand Ldh_1_C PF02866.18 KPI84449.1 - 4.2e-24 85.3 0.0 9.2e-24 84.3 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KPI84449.1 - 4.3e-16 59.3 0.1 6.5e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KPI84449.1 - 0.017 14.5 0.1 0.027 13.8 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KPI84449.1 - 0.12 12.9 0.2 0.36 11.4 0.1 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Cullin_Nedd8 PF10557.9 KPI84450.1 - 6.5e-15 54.9 0.3 1.4e-14 53.8 0.3 1.6 1 0 0 1 1 1 1 Cullin protein neddylation domain Peptidase_S9 PF00326.21 KPI84451.1 - 5.9e-35 120.7 0.0 1.2e-34 119.7 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.21 KPI84451.1 - 1.3e-22 80.1 0.1 2e-22 79.5 0.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_3 PF07859.13 KPI84451.1 - 0.028 14.3 0.0 0.078 12.8 0.0 1.7 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 KPI84451.1 - 0.057 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Putative esterase PPR_3 PF13812.6 KPI84452.1 - 1.2e-10 41.3 0.0 1.7e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KPI84452.1 - 6.1e-06 25.7 0.0 0.061 12.7 0.0 2.2 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_2 PF13041.6 KPI84452.1 - 0.0026 17.9 0.0 0.11 12.7 0.0 2.7 2 1 1 3 3 3 1 PPR repeat family Sensor PF13796.6 KPI84453.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative sensor DUF948 PF06103.11 KPI84454.1 - 0.014 15.7 2.4 0.014 15.7 2.4 12.6 10 4 4 14 14 14 0 Bacterial protein of unknown function (DUF948) DUF3800 PF12686.7 KPI84454.1 - 0.073 13.7 0.0 22 5.7 0.0 5.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Vps54_N PF10475.9 KPI84455.1 - 6.6e-12 45.3 2.1 1.3e-11 44.4 2.1 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 KPI84455.1 - 7.9e-12 45.5 0.6 3.6e-10 40.0 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Sec8_exocyst PF04048.14 KPI84455.1 - 0.14 12.1 0.5 0.39 10.6 0.5 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain GDPD PF03009.17 KPI84456.1 - 1.7e-19 70.6 0.0 2.5e-19 70.0 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF1319 PF07028.11 KPI84458.1 - 0.0022 18.2 0.2 0.0048 17.1 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1319) UQ_con PF00179.26 KPI84459.1 - 7.9e-07 28.8 0.1 1.5e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KPI84459.1 - 0.19 12.0 0.0 0.26 11.6 0.0 1.2 1 0 0 1 1 1 0 RWD domain UQ_con PF00179.26 KPI84460.1 - 9e-46 155.0 0.1 1e-45 154.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KPI84460.1 - 0.00037 20.3 0.2 0.00069 19.5 0.2 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 KPI84460.1 - 0.026 14.8 0.0 0.053 13.8 0.1 1.4 1 1 0 1 1 1 0 RWD domain SOG2 PF10428.9 KPI84461.1 - 8.1 5.5 17.3 13 4.9 17.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein HMG_CoA_synt_N PF01154.17 KPI84462.1 - 4.6e-10 39.6 0.4 9.8e-10 38.6 0.4 1.5 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 KPI84462.1 - 3.7e-07 30.1 0.0 2.1e-05 24.3 0.0 2.3 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Barwin PF00967.17 KPI84462.1 - 0.052 13.4 0.2 0.14 12.0 0.1 1.7 2 0 0 2 2 2 0 Barwin family ACP_syn_III_C PF08541.10 KPI84462.1 - 0.13 12.4 0.1 1.1 9.5 0.0 2.5 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 KPI84462.1 - 0.15 12.0 2.1 0.16 11.8 0.6 1.9 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ADSL_C PF10397.9 KPI84463.1 - 0.085 13.4 1.3 0.92 10.1 0.1 2.3 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus Kelch_4 PF13418.6 KPI84464.1 - 3.9e-38 129.2 8.7 7.8e-07 29.0 0.0 7.0 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KPI84464.1 - 4.6e-37 125.6 9.7 4.2e-08 33.3 0.0 7.7 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.25 KPI84464.1 - 9.3e-37 124.4 19.1 4.6e-09 35.7 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KPI84464.1 - 8.5e-31 105.4 13.4 3.1e-07 30.2 0.4 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KPI84464.1 - 2.3e-27 94.3 8.1 2e-06 27.8 0.2 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KPI84464.1 - 9.2e-24 82.5 16.2 4.4e-05 23.3 0.0 6.6 6 1 0 6 6 6 6 Kelch motif Ribosomal_S8e PF01201.22 KPI84465.1 - 3.5e-46 156.8 2.0 4.3e-46 156.5 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Pkinase PF00069.25 KPI84467.1 - 4.9e-20 72.0 0.0 3.8e-07 29.8 0.0 3.5 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84467.1 - 0.001 18.4 0.1 1.1 8.5 0.0 3.3 3 0 0 3 3 3 2 Protein tyrosine kinase Sporozoite_P67 PF05642.11 KPI84468.1 - 0.64 8.0 1.4 1 7.4 1.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Flot PF15975.5 KPI84468.1 - 5.2 7.3 10.4 19 5.5 9.6 2.3 2 0 0 2 2 2 0 Flotillin DUF4407 PF14362.6 KPI84468.1 - 8.7 5.6 9.7 14 4.9 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ThiF PF00899.21 KPI84471.1 - 8e-73 244.8 0.0 1.1e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 KPI84471.1 - 0.024 14.9 0.1 0.046 14.0 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 KPI84471.1 - 0.1 13.1 0.1 0.7 10.4 0.0 2.2 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 KPI84471.1 - 0.15 12.1 0.0 0.42 10.7 0.0 1.6 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 KPI84471.1 - 0.17 12.5 0.1 0.36 11.4 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PLAC8 PF04749.17 KPI84472.1 - 1.2e-08 35.8 4.9 2.2e-07 31.8 4.9 2.2 1 1 0 1 1 1 1 PLAC8 family Mucin PF01456.17 KPI84472.1 - 0.0015 18.5 9.0 0.0033 17.4 9.0 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein PLAC8 PF04749.17 KPI84473.1 - 4.3e-14 53.3 27.5 5.7e-14 52.9 27.5 1.2 1 0 0 1 1 1 1 PLAC8 family Folate_carrier PF01770.18 KPI84474.1 - 0.086 11.6 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier WD40 PF00400.32 KPI84475.1 - 4.1e-17 62.2 3.7 1.4e-05 25.8 0.1 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI84475.1 - 0.034 14.4 0.0 6.5 7.1 0.0 3.6 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2040 PF09745.9 KPI84478.1 - 0.0003 20.8 1.6 0.00055 20.0 0.1 2.2 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) Nnf1 PF03980.14 KPI84479.1 - 0.013 15.8 1.0 0.026 14.9 0.1 2.0 2 0 0 2 2 2 0 Nnf1 SPX PF03105.19 KPI84479.1 - 0.65 9.8 3.8 0.9 9.4 3.8 1.3 1 0 0 1 1 1 0 SPX domain APH PF01636.23 KPI84480.1 - 1.8e-09 37.9 1.6 2.4e-08 34.2 0.1 2.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KPI84480.1 - 0.031 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Cyclin PF08613.11 KPI84481.1 - 3.9e-28 98.8 0.5 1.6e-27 96.8 0.0 2.4 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 KPI84481.1 - 0.0064 16.2 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain NIF PF03031.18 KPI84482.1 - 5.2e-22 78.3 0.5 6.3e-20 71.5 0.1 2.3 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase ATP-synt_E PF05680.12 KPI84482.1 - 1.1 9.7 3.4 35 4.8 1.7 2.8 2 0 0 2 2 2 0 ATP synthase E chain His_Phos_1 PF00300.22 KPI84486.1 - 1.1e-25 90.4 0.0 7.8e-25 87.7 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 KPI84486.1 - 0.033 13.5 0.0 0.71 9.2 0.0 2.1 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) Pkinase_Tyr PF07714.17 KPI84487.1 - 0.022 14.1 0.0 0.094 12.0 0.0 1.9 1 1 0 1 1 1 0 Protein tyrosine kinase T3SS_needle_E PF08988.10 KPI84487.1 - 0.044 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle Arm PF00514.23 KPI84487.1 - 0.11 12.6 0.5 9.4 6.4 0.0 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat PUB PF09409.10 KPI84488.1 - 6.6e-16 58.0 0.0 1.5e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 PUB domain DUF1068 PF06364.12 KPI84488.1 - 0.011 15.6 6.8 0.011 15.6 6.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) zf-C4H2 PF10146.9 KPI84488.1 - 0.78 10.0 10.6 1.2 9.4 10.6 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein ASL_C2 PF14698.6 KPI84488.1 - 4 8.3 7.1 1.4 9.7 0.5 3.1 3 0 0 3 3 3 0 Argininosuccinate lyase C-terminal 5_3_exonuc PF01367.20 KPI84488.1 - 7.6 7.2 7.6 9.2 6.9 3.0 2.8 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold Pox_MCEL PF03291.16 KPI84489.1 - 1.2e-33 116.6 0.0 1.5e-32 113.0 0.0 2.1 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.12 KPI84489.1 - 0.00064 20.4 0.0 0.0028 18.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84489.1 - 0.00066 20.3 0.0 0.0029 18.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI84489.1 - 0.0093 15.8 0.0 0.019 14.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Cadherin_2 PF08266.12 KPI84490.1 - 1.1e-05 25.1 4.2 0.08 12.8 0.8 3.0 2 0 0 2 2 2 2 Cadherin-like IMS PF00817.20 KPI84491.1 - 6.5e-35 120.3 0.1 1.3e-34 119.4 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KPI84491.1 - 2.2e-05 25.2 0.1 5.4e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain TetR_C_20 PF17925.1 KPI84492.1 - 0.099 13.0 0.4 15 6.0 0.0 3.6 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain LCM PF04072.14 KPI84493.1 - 3.1e-23 82.7 0.0 9.9e-23 81.1 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase TPR_1 PF00515.28 KPI84494.1 - 2.5e-38 128.4 15.7 7e-08 32.0 0.5 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84494.1 - 9.3e-34 112.8 13.4 5.3e-07 29.3 0.0 6.4 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 KPI84494.1 - 1.1e-21 75.1 12.4 0.0017 18.4 0.0 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 KPI84494.1 - 1.3e-20 72.8 12.6 2e-05 24.1 0.3 6.1 4 2 2 6 6 6 4 TPR repeat TPR_7 PF13176.6 KPI84494.1 - 1.8e-15 55.8 2.2 0.007 16.3 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KPI84494.1 - 4.8e-14 52.7 3.9 0.0063 17.1 0.2 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84494.1 - 4.1e-13 49.4 13.6 0.021 15.1 0.6 5.0 2 2 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84494.1 - 1.7e-11 43.9 3.6 0.025 15.4 0.0 5.0 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI84494.1 - 5.4e-10 39.3 0.6 0.0003 20.9 0.2 3.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KPI84494.1 - 8.8e-09 35.5 6.8 0.03 14.9 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI84494.1 - 2.7e-08 33.6 7.0 0.03 14.7 0.1 6.2 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI84494.1 - 4.6e-08 33.5 10.1 0.058 13.9 0.2 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI84494.1 - 3.2e-06 27.3 4.7 0.043 14.0 0.1 3.3 2 2 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KPI84494.1 - 7.6e-06 25.6 10.2 0.025 14.5 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF3856 PF12968.7 KPI84494.1 - 1.6e-05 25.0 3.9 0.04 14.0 0.6 3.4 2 1 0 2 2 2 2 Domain of Unknown Function (DUF3856) MIT PF04212.18 KPI84494.1 - 2.1e-05 24.5 15.8 0.13 12.4 0.4 4.6 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 KPI84494.1 - 0.00052 19.4 4.1 0.54 9.7 0.0 4.9 5 0 0 5 5 5 1 SHNi-TPR Fis1_TPR_C PF14853.6 KPI84494.1 - 0.004 17.2 6.0 8.5 6.5 0.1 5.2 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat SPO22 PF08631.10 KPI84494.1 - 0.0077 15.8 7.4 0.023 14.2 0.9 2.8 4 0 0 4 4 4 1 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 KPI84494.1 - 0.025 14.6 10.2 0.13 12.3 0.3 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat MAS20 PF02064.15 KPI84494.1 - 0.046 13.8 2.9 8.8 6.4 1.6 3.3 2 1 1 3 3 3 0 MAS20 protein import receptor DUF5398 PF17376.2 KPI84494.1 - 0.056 14.1 0.3 27 5.5 0.3 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5398) PPR PF01535.20 KPI84494.1 - 0.25 11.7 3.6 33 5.0 0.0 4.0 4 0 0 4 4 4 0 PPR repeat Clathrin PF00637.20 KPI84494.1 - 0.3 11.0 2.2 5.6 6.8 0.2 2.5 2 0 0 2 2 2 0 Region in Clathrin and VPS Sel1 PF08238.12 KPI84494.1 - 0.33 11.7 11.8 1.9 9.3 0.7 3.8 3 1 1 4 4 4 0 Sel1 repeat SAP PF02037.27 KPI84495.1 - 6.5e-09 35.3 0.0 1.1e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 KPI84495.1 - 0.014 15.1 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 HeH/LEM domain CDC45 PF02724.14 KPI84495.1 - 0.054 11.8 0.8 0.073 11.4 0.8 1.1 1 0 0 1 1 1 0 CDC45-like protein XRCC4 PF06632.12 KPI84495.1 - 0.36 9.6 4.0 0.52 9.1 4.0 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 FGGY_C PF02782.16 KPI84496.1 - 3.5e-39 134.6 0.2 5.9e-39 133.9 0.2 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KPI84496.1 - 9e-09 35.2 0.0 2e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain PUF PF00806.19 KPI84497.1 - 9.7e-31 103.7 9.7 1.1e-05 24.8 0.4 8.1 7 1 1 8 8 8 7 Pumilio-family RNA binding repeat Amidohydro_1 PF01979.20 KPI84498.1 - 1.2e-11 44.6 1.6 1.5e-10 40.9 1.6 2.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KPI84498.1 - 1.4e-08 34.7 0.1 0.012 15.1 0.0 3.1 3 0 0 3 3 3 2 Amidohydrolase family DHR-2 PF06920.13 KPI84498.1 - 0.03 13.0 0.0 0.042 12.5 0.0 1.2 1 0 0 1 1 1 0 Dock homology region 2 DUF630 PF04783.12 KPI84499.1 - 0.046 13.9 0.0 0.082 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF630) U-box PF04564.15 KPI84500.1 - 1.4e-11 44.4 0.0 2.9e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain SpoU_methylase PF00588.19 KPI84501.1 - 7.2e-14 52.2 0.0 1.2e-12 48.3 0.0 2.7 2 1 0 2 2 2 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 KPI84501.1 - 5.5e-06 26.6 0.0 0.00083 19.6 0.0 2.5 2 0 0 2 2 2 2 RNA 2'-O ribose methyltransferase substrate binding Cnd2 PF05786.14 KPI84504.1 - 5.5e-26 91.5 7.5 3.4e-18 65.7 0.6 2.9 3 1 0 3 3 3 2 Condensin complex subunit 2 CNDH2_N PF06278.11 KPI84504.1 - 0.0027 17.9 0.4 0.0059 16.8 0.0 1.7 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal NAD_kinase PF01513.21 KPI84505.1 - 6.1e-10 38.8 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 ATP-NAD kinase TPR_12 PF13424.6 KPI84507.1 - 1.6e-07 31.5 1.2 0.00013 22.1 0.7 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 KPI84507.1 - 1.5e-06 27.9 0.9 0.055 13.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84507.1 - 0.0011 18.8 1.3 0.047 13.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84507.1 - 0.0094 16.0 0.6 0.053 13.7 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Spt20 PF12090.8 KPI84507.1 - 0.026 14.2 2.2 0.058 13.0 2.2 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 KPI84507.1 - 2.8 7.8 17.6 0.5 10.3 3.7 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Kinesin PF00225.23 KPI84508.1 - 2.6e-09 36.5 0.0 0.00013 21.0 0.0 2.7 2 0 0 2 2 2 2 Kinesin motor domain UPF0231 PF06062.11 KPI84508.1 - 0.0042 17.3 1.2 0.0042 17.3 1.2 2.5 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0231) TMF_DNA_bd PF12329.8 KPI84508.1 - 0.016 15.2 7.8 0.016 15.2 7.8 2.9 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding HCMV_UL139 PF12507.8 KPI84508.1 - 0.13 12.6 6.4 2.1 8.8 0.2 2.6 1 1 1 2 2 2 0 Human Cytomegalovirus UL139 protein AAA_13 PF13166.6 KPI84508.1 - 0.19 10.3 10.2 0.34 9.5 10.2 1.4 1 0 0 1 1 1 0 AAA domain SHE3 PF17078.5 KPI84508.1 - 0.55 9.9 10.3 0.45 10.2 8.3 1.7 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 NPV_P10 PF05531.12 KPI84508.1 - 1.8 9.1 10.2 0.52 10.8 2.2 3.4 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF2730 PF10805.8 KPI84508.1 - 1.9 8.6 8.9 0.37 10.9 3.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.11 KPI84508.1 - 2.4 8.6 7.3 3.8 8.0 0.7 3.9 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) FAM76 PF16046.5 KPI84508.1 - 4.7 6.5 12.2 0.52 9.6 5.4 2.1 2 0 0 2 2 2 0 FAM76 protein AAA_23 PF13476.6 KPI84508.1 - 8.8 6.8 7.6 4.4 7.8 5.2 1.6 2 0 0 2 2 2 0 AAA domain Pol_alpha_B_N PF08418.10 KPI84509.1 - 0.35 10.8 8.0 0.082 12.9 3.6 2.1 1 1 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF4551 PF15087.6 KPI84509.1 - 1.4 7.6 3.1 2.3 6.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ribosomal_L19e PF01280.20 KPI84510.1 - 1.1e-59 200.6 11.1 1.1e-59 200.6 11.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L19e DUF2202 PF09968.9 KPI84510.1 - 0.028 14.3 0.7 0.045 13.6 0.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) Neur_chan_memb PF02932.16 KPI84510.1 - 7.4 6.5 6.2 9.6 6.2 6.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OrfB_Zn_ribbon PF07282.11 KPI84511.1 - 0.34 10.9 2.1 0.5 10.3 0.4 2.0 2 0 0 2 2 2 0 Putative transposase DNA-binding domain WSK PF03832.13 KPI84513.1 - 0.12 12.1 0.1 0.29 10.8 0.1 1.7 1 0 0 1 1 1 0 WSK motif Methyltransf_23 PF13489.6 KPI84514.1 - 1.5e-13 50.9 0.0 2.4e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI84514.1 - 5.4e-12 45.7 0.0 6.7e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KPI84514.1 - 5.7e-09 36.5 0.0 0.002 18.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84514.1 - 2e-08 34.9 0.1 2.6e-05 24.8 0.0 2.6 1 1 2 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84514.1 - 1.2e-07 32.3 0.0 1.3e-06 29.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 KPI84514.1 - 0.01 15.0 0.0 0.019 14.1 0.0 1.5 1 1 0 1 1 1 0 DREV methyltransferase CMAS PF02353.20 KPI84514.1 - 0.011 15.0 0.1 0.044 13.1 0.0 1.9 2 1 1 3 3 3 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 KPI84514.1 - 0.098 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 KPI84514.1 - 0.14 11.0 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PHD PF00628.29 KPI84515.1 - 6.1e-05 22.8 2.5 0.00011 22.0 2.5 1.5 1 0 0 1 1 1 1 PHD-finger Zn_ribbon_17 PF17120.5 KPI84515.1 - 0.042 13.5 1.2 0.086 12.5 1.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 KPI84515.1 - 2.5 8.1 8.6 0.32 10.9 4.4 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-dskA_traR PF01258.17 KPI84515.1 - 2.6 8.1 7.7 0.93 9.5 0.2 3.1 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger PQ-loop PF04193.14 KPI84518.1 - 6e-20 70.8 0.5 1.2e-14 53.8 0.0 2.7 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 KPI84518.1 - 0.21 12.4 9.0 1.8 9.4 9.0 2.3 1 1 0 1 1 1 0 ER lumen protein retaining receptor eIF3m_C_helix PF18005.1 KPI84519.1 - 1.1 9.0 4.7 3 7.6 1.8 2.4 2 0 0 2 2 2 0 eIF3 subunit M, C-terminal helix Pkinase PF00069.25 KPI84520.1 - 2.2e-12 46.9 0.0 1.7e-09 37.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84520.1 - 4.1e-07 29.6 0.2 5.1e-05 22.7 0.1 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase Peptidase_C48 PF02902.19 KPI84521.1 - 4.2e-14 52.9 0.1 4.1e-05 23.5 0.0 3.3 2 1 1 3 3 3 3 Ulp1 protease family, C-terminal catalytic domain Metallophos PF00149.28 KPI84524.1 - 8e-16 59.1 0.0 1.6e-13 51.6 0.0 3.1 3 0 0 3 3 3 2 Calcineurin-like phosphoesterase UDPGT PF00201.18 KPI84525.1 - 3.4e-31 108.6 0.1 6.2e-31 107.8 0.0 1.4 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Cys_Met_Meta_PP PF01053.20 KPI84526.1 - 1.3e-116 389.2 0.0 1.7e-116 388.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KPI84526.1 - 4.4e-06 26.1 0.0 8.1e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KPI84526.1 - 0.00046 19.3 0.0 0.00074 18.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V bZIP_2 PF07716.15 KPI84526.1 - 0.37 10.9 1.6 1.1 9.4 1.6 1.8 1 0 0 1 1 1 0 Basic region leucine zipper Nudc_N PF14050.6 KPI84527.1 - 1.6e-14 53.6 0.0 3.4e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 KPI84527.1 - 2.6e-14 54.0 0.0 4.3e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 CS domain Mus7 PF09462.10 KPI84527.1 - 0.024 13.5 0.2 0.027 13.3 0.2 1.2 1 0 0 1 1 1 0 Mus7/MMS22 family Borrelia_P83 PF05262.11 KPI84527.1 - 0.19 10.2 15.5 0.022 13.3 11.2 1.5 1 1 1 2 2 2 0 Borrelia P83/100 protein Ndc1_Nup PF09531.10 KPI84527.1 - 0.48 9.0 1.6 0.46 9.1 1.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 KPI84527.1 - 1.5 6.9 6.4 2.3 6.2 6.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein F-box PF00646.33 KPI84528.1 - 0.012 15.4 0.1 0.037 13.9 0.1 1.8 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 KPI84528.1 - 0.031 14.2 0.1 0.096 12.6 0.1 1.9 1 0 0 1 1 1 0 F-box-like Pyr_redox_2 PF07992.14 KPI84529.1 - 3e-18 66.1 0.0 3.1e-17 62.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KPI84529.1 - 1.3e-11 44.9 0.0 4.1e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KPI84529.1 - 5.6e-06 26.2 0.0 0.022 14.4 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KPI84529.1 - 8.6e-06 25.0 0.0 0.026 13.6 0.0 3.1 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KPI84529.1 - 7.6e-05 22.9 1.5 0.45 10.8 0.0 3.3 4 0 0 4 4 3 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KPI84529.1 - 0.0006 19.8 0.1 0.43 10.6 0.0 3.4 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 KPI84529.1 - 0.0023 18.4 0.0 0.53 10.8 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding K_oxygenase PF13434.6 KPI84529.1 - 0.0026 16.9 0.0 0.011 14.9 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Aegerolysin PF06355.13 KPI84529.1 - 0.023 14.8 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 Aegerolysin 3HCDH_N PF02737.18 KPI84529.1 - 0.024 14.5 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 KPI84529.1 - 0.026 13.8 0.0 0.53 9.5 0.0 2.4 2 0 0 2 2 2 0 Thi4 family GIDA PF01134.22 KPI84529.1 - 0.029 13.5 0.0 13 4.7 0.0 2.9 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KPI84529.1 - 0.062 12.5 0.0 0.5 9.6 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.23 KPI84529.1 - 0.078 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.6 KPI84529.1 - 0.12 11.6 0.1 3.1 7.0 0.0 2.5 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Trp_leader2 PF08056.11 KPI84529.1 - 0.81 9.7 4.9 1.8 8.6 4.9 1.5 1 0 0 1 1 1 0 Tryptophan operon leader peptide mRNA_triPase PF02940.15 KPI84530.1 - 1.8e-09 37.7 0.0 0.00055 19.7 0.0 2.2 2 0 0 2 2 2 2 mRNA capping enzyme, beta chain PDZ_5 PF17817.1 KPI84530.1 - 0.11 12.7 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Dzip-like_N PF13815.6 KPI84531.1 - 1.2e-39 134.9 4.4 1.2e-39 134.9 4.4 2.2 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal zf-Di19 PF05605.12 KPI84531.1 - 0.00013 22.2 0.3 0.0002 21.6 0.3 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding KASH_CCD PF14662.6 KPI84531.1 - 0.00039 20.3 4.5 0.00039 20.3 4.5 2.3 3 0 0 3 3 3 1 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.6 KPI84531.1 - 0.005 16.2 0.4 0.054 12.8 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) zf-C2H2_4 PF13894.6 KPI84531.1 - 0.041 14.7 1.8 0.077 13.9 1.8 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI84531.1 - 0.041 14.3 2.1 0.073 13.6 2.1 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type ATG16 PF08614.11 KPI84531.1 - 0.088 13.0 18.2 0.53 10.5 0.3 3.5 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Tmemb_9 PF05434.11 KPI84531.1 - 0.11 12.4 0.7 0.21 11.5 0.7 1.3 1 0 0 1 1 1 0 TMEM9 SopD PF11047.8 KPI84531.1 - 0.17 11.0 0.0 0.25 10.5 0.0 1.1 1 0 0 1 1 1 0 Salmonella outer protein D Wtap PF17098.5 KPI84531.1 - 0.41 10.6 6.9 7.3 6.5 1.0 3.1 3 0 0 3 3 3 0 WTAP/Mum2p family DUF4140 PF13600.6 KPI84531.1 - 0.79 10.2 8.9 6.9 7.2 0.1 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) UTP25 PF06862.12 KPI84532.1 - 3.3e-111 372.4 3.9 3.1e-104 349.4 0.3 2.1 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Choline_transpo PF04515.12 KPI84535.1 - 8.2e-55 186.3 36.4 8.2e-55 186.3 36.4 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF3292 PF11696.8 KPI84535.1 - 0.47 8.8 3.5 7.7 4.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) FKBP_C PF00254.28 KPI84538.1 - 2.9e-25 88.4 0.0 4.2e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase IQ PF00612.27 KPI84539.1 - 9e-08 31.3 52.1 0.0084 15.8 1.3 10.0 9 0 0 9 9 9 6 IQ calmodulin-binding motif Ras PF00071.22 KPI84541.1 - 1.3e-59 200.4 0.1 1.5e-59 200.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI84541.1 - 3.2e-33 114.5 0.1 5.7e-33 113.7 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI84541.1 - 2.6e-14 53.0 0.0 3.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI84541.1 - 4.1e-05 23.6 0.0 6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI84541.1 - 4.5e-05 23.1 0.0 0.0002 21.0 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KPI84541.1 - 0.00024 21.1 0.3 0.029 14.3 0.1 2.3 1 1 1 2 2 2 1 RsgA GTPase Ploopntkinase3 PF18751.1 KPI84541.1 - 0.0011 18.9 0.0 1 9.2 0.0 2.2 2 0 0 2 2 2 2 P-loop Nucleotide Kinase3 DLIC PF05783.11 KPI84541.1 - 0.0025 16.7 0.0 1.4 7.7 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) SRPRB PF09439.10 KPI84541.1 - 0.0027 17.2 0.2 0.0051 16.3 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KPI84541.1 - 0.0034 16.8 0.0 0.004 16.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KPI84541.1 - 0.019 15.2 0.0 0.035 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain Amidase02_C PF12123.8 KPI84541.1 - 0.026 14.2 0.0 0.24 11.1 0.0 2.3 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase AAA_24 PF13479.6 KPI84541.1 - 0.035 13.8 0.1 0.062 13.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 KPI84541.1 - 0.041 13.1 0.1 0.06 12.6 0.1 1.2 1 0 0 1 1 1 0 Septin AAA_7 PF12775.7 KPI84541.1 - 0.043 13.3 0.2 0.064 12.8 0.2 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 KPI84541.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 KPI84541.1 - 0.19 12.1 0.0 0.3 11.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain FA_desaturase PF00487.24 KPI84542.1 - 1 9.2 7.7 0.058 13.2 2.7 1.4 2 0 0 2 2 2 0 Fatty acid desaturase TPPK_C PF12555.8 KPI84542.1 - 1.4 9.0 7.8 0.095 12.8 1.9 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal DUF4064 PF13273.6 KPI84543.1 - 2.2 8.6 13.4 6.9 7.0 0.1 4.5 3 1 0 4 4 4 0 Protein of unknown function (DUF4064) IF-2B PF01008.17 KPI84546.1 - 7.6e-40 136.9 0.0 3.6e-39 134.7 0.0 1.9 1 1 0 1 1 1 1 Initiation factor 2 subunit family DUF3829 PF12889.7 KPI84547.1 - 6.2 6.2 13.3 12 5.3 13.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) AAA_16 PF13191.6 KPI84548.1 - 1.4e-07 32.1 0.0 3.7e-07 30.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 KPI84548.1 - 1.1e-06 28.9 0.1 3.9e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KPI84548.1 - 5.3e-06 26.1 0.1 0.28 10.7 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KPI84548.1 - 2.6e-05 24.5 0.1 0.0015 18.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 KPI84548.1 - 0.00021 21.3 0.0 0.004 17.1 0.0 2.2 2 0 0 2 2 2 1 NACHT domain FtsK_SpoIIIE PF01580.18 KPI84548.1 - 0.00042 19.7 0.0 0.00087 18.7 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 KPI84548.1 - 0.00092 19.2 0.0 0.082 12.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 KPI84548.1 - 0.0018 17.5 0.0 0.01 15.0 0.0 2.0 2 0 0 2 2 2 1 G-protein alpha subunit AAA_29 PF13555.6 KPI84548.1 - 0.0031 17.2 0.0 0.0068 16.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KPI84548.1 - 0.0035 17.8 0.0 0.0057 17.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 KPI84548.1 - 0.0049 17.0 3.3 0.055 13.6 0.1 3.2 3 0 0 3 3 3 1 AAA domain ATP_bind_1 PF03029.17 KPI84548.1 - 0.0054 16.5 0.6 0.4 10.4 0.4 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 KPI84548.1 - 0.0068 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain cobW PF02492.19 KPI84548.1 - 0.0087 15.7 1.4 0.14 11.8 0.2 2.5 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 KPI84548.1 - 0.0089 15.8 1.0 0.28 10.9 0.0 3.0 2 1 1 3 3 3 1 AAA domain T2SSE PF00437.20 KPI84548.1 - 0.014 14.5 0.2 0.033 13.2 0.1 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein PRK PF00485.18 KPI84548.1 - 0.019 14.7 0.1 0.036 13.8 0.1 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Septin PF00735.18 KPI84548.1 - 0.021 14.1 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_19 PF13245.6 KPI84548.1 - 0.021 15.2 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 KPI84548.1 - 0.032 13.7 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein DLIC PF05783.11 KPI84548.1 - 0.034 13.0 0.1 0.072 11.9 0.0 1.6 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) DAP3 PF10236.9 KPI84548.1 - 0.042 13.0 0.0 0.1 11.7 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 MobB PF03205.14 KPI84548.1 - 0.042 13.7 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRPRB PF09439.10 KPI84548.1 - 0.068 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Arf PF00025.21 KPI84548.1 - 0.075 12.5 0.0 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family Ras PF00071.22 KPI84548.1 - 0.082 12.5 0.0 0.61 9.7 0.0 2.1 2 0 0 2 2 2 0 Ras family AAA_30 PF13604.6 KPI84548.1 - 0.097 12.4 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 KPI84548.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase NTPase_1 PF03266.15 KPI84548.1 - 0.13 12.2 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.12 KPI84548.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Microtub_bd PF16796.5 KPI84548.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Microtubule binding AAA PF00004.29 KPI84548.1 - 0.16 12.4 0.0 0.91 10.0 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KPI84548.1 - 9.2 5.8 7.1 6.9 6.2 0.3 3.0 2 2 1 3 3 3 0 AAA domain Pkinase PF00069.25 KPI84550.1 - 1.3e-75 254.2 0.0 1.9e-75 253.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84550.1 - 2.1e-35 122.3 0.0 4e-35 121.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KPI84550.1 - 0.0034 17.1 0.2 2.2 7.8 0.0 2.6 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 KPI84550.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 KPI84550.1 - 0.015 14.7 0.2 0.026 13.9 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KPI84550.1 - 0.018 14.4 0.0 0.044 13.1 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 KPI84550.1 - 0.023 13.6 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KPI84550.1 - 0.043 13.7 0.5 1.1 9.1 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Glucosamine_iso PF01182.20 KPI84551.1 - 3.4e-20 72.9 0.0 4.2e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase UAF_Rrn10 PF05234.11 KPI84551.1 - 0.071 13.3 0.1 0.79 10.0 0.0 2.3 2 1 0 2 2 2 0 UAF complex subunit Rrn10 Cpn60_TCP1 PF00118.24 KPI84553.1 - 2.5e-147 491.5 9.9 2.9e-147 491.3 9.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MotA_ExbB PF01618.16 KPI84555.1 - 2.3 8.0 0.0 2.3 8.0 0.0 2.7 3 0 0 3 3 3 0 MotA/TolQ/ExbB proton channel family DnaJ_C PF01556.18 KPI84556.1 - 2.2e-05 24.6 0.0 2.2e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KPI84556.1 - 0.0082 16.5 0.1 0.011 16.1 0.1 1.2 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI84556.1 - 0.029 14.3 0.1 0.044 13.7 0.1 1.3 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Pyr_redox_2 PF07992.14 KPI84557.1 - 6.2e-67 225.9 8.9 1.7e-66 224.5 5.6 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KPI84557.1 - 2e-40 137.5 0.8 5.3e-40 136.1 0.8 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KPI84557.1 - 5e-17 62.2 10.9 2e-16 60.3 1.8 3.2 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KPI84557.1 - 1.8e-13 50.4 12.7 1.9e-12 47.1 0.1 3.2 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KPI84557.1 - 2.1e-11 43.6 4.3 5.4e-10 38.9 0.4 2.6 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 KPI84557.1 - 8.5e-08 32.0 0.8 8.5e-08 32.0 0.8 3.1 3 1 1 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KPI84557.1 - 2.6e-07 30.8 4.6 5e-05 23.4 0.5 2.7 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KPI84557.1 - 1.7e-05 24.1 12.6 0.00012 21.3 3.1 3.4 2 1 0 3 3 3 1 FAD binding domain K_oxygenase PF13434.6 KPI84557.1 - 0.00016 20.9 1.0 0.0066 15.6 0.0 2.4 2 1 1 3 3 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 KPI84557.1 - 0.00022 20.6 2.5 0.0013 18.0 0.3 2.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 KPI84557.1 - 0.00032 20.1 12.3 0.052 12.8 0.5 3.2 2 1 1 3 3 3 3 FAD binding domain AlaDh_PNT_C PF01262.21 KPI84557.1 - 0.00049 19.4 10.1 0.017 14.5 0.6 3.0 3 1 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KPI84557.1 - 0.00061 18.6 1.2 0.00061 18.6 1.2 3.7 3 1 1 4 4 4 1 HI0933-like protein 3HCDH_N PF02737.18 KPI84557.1 - 0.0019 18.1 7.3 0.0029 17.5 0.3 3.6 3 1 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Arch_flagellin PF01917.16 KPI84557.1 - 0.028 14.6 1.9 0.072 13.3 1.9 1.7 1 1 0 1 1 1 0 Archaebacterial flagellin XdhC_C PF13478.6 KPI84557.1 - 0.03 14.8 0.3 1.3 9.6 0.0 2.5 2 0 0 2 2 2 0 XdhC Rossmann domain Lycopene_cycl PF05834.12 KPI84557.1 - 0.081 12.0 0.9 4.6 6.2 0.1 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 KPI84557.1 - 0.21 11.1 12.6 1.2 8.7 1.5 3.0 2 2 2 4 4 4 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 KPI84557.1 - 0.27 10.8 5.9 0.71 9.4 0.8 2.8 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 KPI84557.1 - 2.8 8.4 5.4 13 6.3 1.3 3.0 2 1 0 2 2 2 0 Putative NAD(P)-binding DUF1930 PF09122.10 KPI84558.1 - 4.1e-24 84.3 0.0 9.2e-24 83.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1930) Rhodanese PF00581.20 KPI84558.1 - 4.5e-16 59.3 0.0 1.4e-08 35.2 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Complex1_51K PF01512.17 KPI84559.1 - 5.4e-44 149.7 0.0 9.2e-44 149.0 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 KPI84559.1 - 1.3e-28 98.9 0.0 3.1e-28 97.7 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 KPI84559.1 - 1.5e-07 31.2 0.0 2.7e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 SLBB domain zf-C3HC4_3 PF13920.6 KPI84561.1 - 0.00016 21.5 3.7 0.00027 20.8 3.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C2HC5 PF06221.13 KPI84561.1 - 0.00017 21.5 1.9 0.00017 21.5 1.9 1.5 2 0 0 2 2 2 1 Putative zinc finger motif, C2HC5-type zf-RING_5 PF14634.6 KPI84561.1 - 0.00027 20.9 3.4 0.00027 20.9 3.4 1.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KPI84561.1 - 0.1 13.0 5.5 0.17 12.2 5.5 1.4 1 0 0 1 1 1 0 Ring finger domain TerY_C PF15616.6 KPI84561.1 - 0.24 11.5 3.0 0.37 10.9 3.0 1.4 1 0 0 1 1 1 0 TerY-C metal binding domain Prok-RING_4 PF14447.6 KPI84561.1 - 0.91 9.4 6.5 2.7 7.9 6.5 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 UPF0020 PF01170.18 KPI84562.1 - 3e-10 40.1 0.0 1.1e-09 38.3 0.0 1.8 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 KPI84562.1 - 0.0032 16.8 0.0 0.01 15.1 0.0 1.7 2 0 0 2 2 2 1 N-6 DNA Methylase PAC4 PF16093.5 KPI84562.1 - 0.0058 16.8 0.1 0.082 13.1 0.1 2.4 2 0 0 2 2 2 1 Proteasome assembly chaperone 4 N6_N4_Mtase PF01555.18 KPI84562.1 - 0.05 13.3 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 DNA methylase PsiA PF06952.11 KPI84563.1 - 0.063 12.5 2.9 0.12 11.6 2.9 1.4 1 0 0 1 1 1 0 PsiA protein Muted PF14942.6 KPI84563.1 - 2.6 8.4 13.0 6.9 7.0 7.4 2.4 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein p47_phox_C PF08944.11 KPI84563.1 - 9.5 5.7 7.2 9.3 5.8 1.8 2.9 3 0 0 3 3 3 0 NADPH oxidase subunit p47Phox, C terminal domain Band_7 PF01145.25 KPI84565.1 - 2.9e-25 89.3 0.1 5.7e-25 88.3 0.1 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 KPI84565.1 - 6.1e-24 83.8 2.6 1.3e-22 79.6 0.4 2.4 2 0 0 2 2 2 2 C-terminal region of band_7 Band_7_1 PF13421.6 KPI84565.1 - 0.0064 16.2 0.5 0.013 15.3 0.1 1.6 2 0 0 2 2 2 1 SPFH domain-Band 7 family Tox-ODYAM1 PF15642.6 KPI84566.1 - 0.017 14.1 1.9 0.031 13.3 1.9 1.4 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus AFG1_ATPase PF03969.16 KPI84567.1 - 9.3e-86 288.0 0.1 1.6e-78 264.2 0.0 3.1 1 1 1 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 KPI84567.1 - 0.00081 19.3 0.1 0.14 12.0 0.0 3.0 2 1 1 3 3 3 1 Bacterial dnaA protein AAA_22 PF13401.6 KPI84567.1 - 0.0021 18.4 0.0 0.0036 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 KPI84567.1 - 0.054 13.4 0.1 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA PF00004.29 KPI84567.1 - 0.15 12.5 0.0 0.46 10.9 0.0 1.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Lectin_leg-like PF03388.13 KPI84568.1 - 1.6e-12 47.3 0.0 4.3e-07 29.5 0.0 2.9 2 1 0 2 2 2 2 Legume-like lectin family YL1 PF05764.13 KPI84568.1 - 0.0001 22.5 0.7 0.00013 22.2 0.7 1.4 1 0 0 1 1 1 1 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 KPI84568.1 - 0.47 10.1 13.1 1.1 9.0 13.1 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ELH PF02323.15 KPI84568.1 - 2.3 7.5 7.5 0.84 9.0 4.3 1.8 2 0 0 2 2 2 0 Egg-laying hormone precursor NOA36 PF06524.12 KPI84568.1 - 9.9 5.4 8.0 22 4.3 8.0 1.5 1 0 0 1 1 1 0 NOA36 protein MORN PF02493.20 KPI84569.1 - 4.8e-25 85.9 24.7 5.4e-08 32.3 1.1 6.9 6 0 0 6 6 6 4 MORN repeat Securin PF04856.13 KPI84569.1 - 0.067 13.1 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor Rad21_Rec8_N PF04825.13 KPI84570.1 - 1.1e-28 99.6 0.1 2e-28 98.7 0.1 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KPI84570.1 - 3.6e-09 35.8 0.1 5.6e-08 32.0 0.0 2.5 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein Methyltransf_31 PF13847.6 KPI84571.1 - 9.6e-11 41.7 0.0 1.2e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI84571.1 - 4.4e-09 36.9 0.0 1.8e-08 34.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84571.1 - 4.6e-09 36.9 0.0 1.3e-08 35.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84571.1 - 1.3e-06 29.1 0.0 2.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KPI84571.1 - 4e-05 23.6 0.0 0.18 11.6 0.0 2.1 2 0 0 2 2 2 2 Hypothetical methyltransferase NodS PF05401.11 KPI84571.1 - 4.7e-05 23.1 0.0 6.9e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 Nodulation protein S (NodS) TPMT PF05724.11 KPI84571.1 - 7.8e-05 22.4 0.0 0.0013 18.4 0.0 2.1 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_32 PF13679.6 KPI84571.1 - 0.0025 17.8 0.0 0.004 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI84571.1 - 0.0089 15.6 0.0 0.028 14.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Pox_MCEL PF03291.16 KPI84571.1 - 0.016 14.3 0.0 0.062 12.4 0.0 1.8 1 1 0 1 1 1 0 mRNA capping enzyme Ubie_methyltran PF01209.18 KPI84571.1 - 0.022 14.1 0.1 0.18 11.1 0.1 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KPI84571.1 - 0.024 14.0 0.0 0.042 13.1 0.0 1.3 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase RrnaAD PF00398.20 KPI84571.1 - 0.03 13.4 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase EutQ PF06249.12 KPI84571.1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ Methyltransf_18 PF12847.7 KPI84571.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.22 KPI84572.1 - 2.3e-07 30.5 0.1 0.15 11.9 0.0 4.0 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DnaJ_C PF01556.18 KPI84573.1 - 3e-36 124.7 0.1 3.9e-36 124.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI84573.1 - 2.9e-22 78.5 0.4 5.7e-22 77.6 0.4 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KPI84573.1 - 6.8e-09 36.0 19.4 1.7e-08 34.7 19.4 1.7 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI84573.1 - 0.04 13.9 18.4 0.5 10.4 3.8 3.0 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KPI84573.1 - 4.2 7.4 11.6 4.3 7.4 2.0 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 KPI84573.1 - 5.9 7.4 10.7 6 7.3 6.7 2.8 1 1 1 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.7 KPI84573.1 - 9.1 6.4 12.8 1.2e+02 2.8 12.8 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 KPI84574.1 - 7.2e-09 35.4 4.7 7.2e-09 35.4 4.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI84574.1 - 3.5e-07 30.4 6.1 3.5e-07 30.4 6.1 2.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 KPI84574.1 - 1.1e-06 28.3 8.4 2.5e-06 27.2 8.4 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI84574.1 - 1.2e-06 28.3 7.9 1.2e-06 28.3 7.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI84574.1 - 4.7e-05 23.3 8.3 0.00012 21.9 8.3 1.7 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KPI84574.1 - 0.00023 21.0 4.9 0.00023 21.0 4.9 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KPI84574.1 - 0.00064 19.7 5.6 0.0021 18.0 5.7 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KPI84574.1 - 0.00066 19.9 14.1 0.0008 19.6 12.0 2.2 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KPI84574.1 - 0.0022 18.0 3.4 0.0039 17.2 1.4 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 KPI84574.1 - 0.0098 15.7 5.2 0.0098 15.7 5.2 1.8 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 KPI84574.1 - 1.3 9.2 6.0 0.95 9.7 1.6 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 KPI84574.1 - 2.6 8.3 8.8 0.1 12.7 2.4 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF1272 PF06906.11 KPI84574.1 - 5.6 7.1 12.2 0.044 13.9 3.8 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1272) zinc-ribbons_6 PF07191.12 KPI84574.1 - 5.7 7.0 12.0 2.8 8.0 9.0 2.1 2 1 0 2 2 2 0 zinc-ribbons DZR PF12773.7 KPI84574.1 - 6.7 6.8 10.8 0.2 11.7 4.0 1.9 2 0 0 2 2 2 0 Double zinc ribbon Cmc1 PF08583.10 KPI84575.1 - 0.00055 19.9 1.7 0.00083 19.3 1.7 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like IQ PF00612.27 KPI84579.1 - 0.0053 16.4 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif TPR_8 PF13181.6 KPI84579.1 - 0.017 15.3 0.1 0.26 11.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84579.1 - 0.034 14.4 0.1 2.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_L30 PF00327.20 KPI84582.1 - 1.9e-05 24.4 0.0 4.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Rhomboid PF01694.22 KPI84583.1 - 2e-08 34.4 2.9 4.4e-08 33.2 2.9 1.5 1 0 0 1 1 1 1 Rhomboid family DuoxA PF10204.9 KPI84583.1 - 0.14 11.1 2.6 0.078 12.0 0.4 1.6 2 0 0 2 2 2 0 Dual oxidase maturation factor Peptidase_C54 PF03416.19 KPI84584.1 - 2.2e-44 152.0 0.0 3.1e-44 151.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Myosin_head PF00063.21 KPI84586.1 - 3e-176 587.6 4.2 4.9e-176 586.9 4.2 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) UBA PF00627.31 KPI84586.1 - 4.6e-08 32.8 0.2 0.00012 21.9 0.3 2.7 2 0 0 2 2 2 2 UBA/TS-N domain AAA_lid_6 PF17866.1 KPI84586.1 - 0.024 14.8 0.0 0.16 12.2 0.0 2.5 2 0 0 2 2 2 0 AAA lid domain AAA_22 PF13401.6 KPI84586.1 - 0.025 14.9 0.1 0.21 11.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 KPI84586.1 - 0.038 13.5 0.0 6.6 6.2 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain CUE PF02845.16 KPI84586.1 - 0.04 13.6 0.1 55 3.6 0.0 3.7 3 0 0 3 3 3 0 CUE domain Myosin_N PF02736.19 KPI84586.1 - 0.055 13.3 0.1 0.19 11.6 0.1 2.0 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 KPI84586.1 - 0.099 13.0 1.3 0.82 10.0 0.0 2.9 4 0 0 4 4 4 0 AAA ATPase domain DUF4618 PF15397.6 KPI84586.1 - 0.29 10.5 5.0 0.04 13.3 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Harakiri PF15196.6 KPI84587.1 - 0.051 14.0 4.1 0.22 12.0 4.1 2.2 1 0 0 1 1 1 0 Activator of apoptosis harakiri DUF1192 PF06698.11 KPI84588.1 - 0.01 15.9 0.4 0.57 10.3 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) UvrD-helicase PF00580.21 KPI84588.1 - 0.015 14.9 3.0 0.018 14.6 3.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain DUF2383 PF09537.10 KPI84588.1 - 0.019 15.3 2.0 5.6 7.3 0.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF2383) HALZ PF02183.18 KPI84588.1 - 0.032 14.5 3.2 1 9.7 0.5 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 KPI84588.1 - 0.058 13.6 7.4 0.099 12.9 1.8 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 RecR PF02132.15 KPI84588.1 - 0.12 11.9 1.4 0.26 10.9 1.4 1.6 1 0 0 1 1 1 0 RecR protein zf-FPG_IleRS PF06827.14 KPI84588.1 - 0.16 11.9 2.8 4.5 7.2 0.3 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Dynactin_p22 PF07426.11 KPI84588.1 - 0.27 11.1 4.1 0.33 10.8 0.3 2.8 2 1 1 3 3 3 0 Dynactin subunit p22 SlyX PF04102.12 KPI84588.1 - 0.27 11.9 10.4 0.78 10.4 0.3 3.1 2 1 1 3 3 3 0 SlyX Wtap PF17098.5 KPI84588.1 - 0.37 10.7 13.1 0.031 14.2 5.9 2.3 1 1 2 3 3 3 0 WTAP/Mum2p family DUF1664 PF07889.12 KPI84588.1 - 0.42 10.7 1.9 1.3 9.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF848 PF05852.11 KPI84588.1 - 1.1 9.3 6.5 0.29 11.3 0.5 2.4 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) TolA_bind_tri PF16331.5 KPI84588.1 - 2.3 8.4 13.8 1 9.5 0.5 3.4 2 2 1 3 3 3 0 TolA binding protein trimerisation ZapB PF06005.12 KPI84588.1 - 3.1 8.3 14.8 1.4 9.4 0.5 3.5 2 1 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 KPI84588.1 - 3.4 8.4 8.5 2.8 8.6 2.3 2.9 2 1 1 3 3 3 0 Initiation control protein YabA Spc7 PF08317.11 KPI84588.1 - 3.5 6.4 12.7 0.11 11.4 1.2 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein bZIP_2 PF07716.15 KPI84588.1 - 5.2 7.2 11.2 5.9 7.1 0.2 3.2 3 1 0 3 3 3 0 Basic region leucine zipper Cornichon PF03311.14 KPI84589.1 - 6.5e-25 87.8 1.8 6.5e-25 87.8 1.8 1.6 1 1 1 2 2 2 1 Cornichon protein DUF3099 PF11298.8 KPI84589.1 - 0.025 14.7 0.8 0.025 14.7 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) DUF3040 PF11239.8 KPI84589.1 - 0.32 11.3 4.1 1.1 9.5 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Cornichon PF03311.14 KPI84590.1 - 1.9e-15 57.2 5.0 1.9e-15 57.2 5.0 1.6 1 1 0 1 1 1 1 Cornichon protein Pox_P21 PF05313.12 KPI84590.1 - 0.013 15.1 0.1 0.013 15.1 0.1 2.4 2 1 0 2 2 2 0 Poxvirus P21 membrane protein DUF2157 PF09925.9 KPI84590.1 - 0.013 15.2 4.7 0.11 12.3 0.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF4191 PF13829.6 KPI84590.1 - 0.19 11.1 0.1 0.19 11.1 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4191) DUF2207 PF09972.9 KPI84590.1 - 0.87 8.3 4.1 4.3 6.0 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) LRRC37AB_C PF14914.6 KPI84590.1 - 2 8.3 4.7 6.5 6.6 0.4 2.3 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain SafA PF17073.5 KPI84590.1 - 3.6 7.6 7.2 1.3 9.0 0.2 2.6 3 0 0 3 3 3 0 Two-component-system connector protein TraL PF07178.11 KPI84590.1 - 8.4 6.9 10.4 4.4 7.9 0.2 3.1 3 0 0 3 3 3 0 TraL protein WD40 PF00400.32 KPI84591.1 - 1e-05 26.2 2.8 1.1 10.3 0.1 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI84591.1 - 5e-05 23.5 0.0 12 6.3 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SHQ1 PF04925.15 KPI84592.1 - 1.8e-34 118.8 0.0 2.8e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 SHQ1 protein TPR_2 PF07719.17 KPI84593.1 - 0.00095 19.1 7.4 0.092 12.9 0.4 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84593.1 - 0.001 18.8 3.0 1 9.3 0.6 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84593.1 - 0.0077 16.5 0.8 0.0077 16.5 0.8 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat S_layer_N PF05123.12 KPI84593.1 - 0.015 15.2 0.2 0.021 14.7 0.1 1.5 1 1 0 1 1 1 0 S-layer like family, N-terminal region TPR_8 PF13181.6 KPI84593.1 - 0.048 13.9 0.6 6.3 7.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3856 PF12968.7 KPI84593.1 - 0.049 13.7 0.8 0.12 12.4 0.8 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_7 PF13176.6 KPI84593.1 - 0.11 12.6 0.4 0.11 12.6 0.4 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat CKS PF01111.19 KPI84594.1 - 1.6e-37 127.6 0.9 1.9e-37 127.4 0.9 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Protamine_like PF06382.11 KPI84595.1 - 0.17 12.0 10.6 0.26 11.5 6.9 2.3 1 1 1 2 2 2 0 Protamine and protamine like LPD7 PF18821.1 KPI84596.1 - 0.01 15.9 1.3 0.016 15.3 1.3 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 7 TYW3 PF02676.14 KPI84598.1 - 1.8e-50 171.3 0.0 2.3e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 TMEM18 PF14770.6 KPI84600.1 - 1.1e-25 89.9 1.5 1.4e-25 89.6 1.5 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 DUF3917 PF13055.6 KPI84600.1 - 0.0065 16.9 1.3 0.013 15.9 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3917) FtsX PF02687.21 KPI84600.1 - 0.22 12.0 5.4 0.55 10.7 5.0 1.9 1 1 1 2 2 2 0 FtsX-like permease family BT1 PF03092.16 KPI84601.1 - 4.5e-25 87.9 17.7 1.4e-17 63.2 4.6 2.1 2 0 0 2 2 2 2 BT1 family ATG22 PF11700.8 KPI84601.1 - 0.032 12.9 19.1 0.047 12.3 18.8 1.3 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like TPR_2 PF07719.17 KPI84603.1 - 1.8e-09 37.0 1.5 0.0078 16.3 0.6 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI84603.1 - 3e-08 33.2 0.3 0.44 10.9 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84603.1 - 1.5e-07 31.6 4.7 0.14 12.4 0.0 4.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84603.1 - 6e-06 25.9 1.4 0.097 12.5 0.3 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KPI84603.1 - 6.2e-06 25.9 1.4 0.39 10.7 0.5 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KPI84603.1 - 7.4e-06 26.3 2.1 2.8 8.8 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI84603.1 - 1e-05 25.2 0.6 0.47 10.6 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84603.1 - 3.6e-05 24.2 2.5 0.3 12.0 0.2 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 KPI84603.1 - 0.0018 18.3 0.1 0.46 10.6 0.0 2.5 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 KPI84603.1 - 0.004 17.6 5.7 0.012 16.0 0.5 3.5 4 1 1 5 5 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 KPI84603.1 - 0.0093 16.5 1.4 21 6.1 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI84603.1 - 0.084 13.1 0.6 2.3 8.5 0.5 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 KPI84603.1 - 0.086 13.1 0.1 31 5.1 0.0 3.4 3 0 0 3 3 3 0 PPR repeat TPR_16 PF13432.6 KPI84603.1 - 0.16 12.7 5.1 1.2 9.9 0.7 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat CAS_CSE1 PF03378.15 KPI84604.1 - 0.049 12.1 0.3 0.074 11.5 0.3 1.2 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus X PF00739.19 KPI84605.1 - 8.5 6.5 10.4 0.39 10.9 3.2 2.5 2 0 0 2 2 2 0 Trans-activation protein X HMG_box PF00505.19 KPI84608.1 - 0.00016 22.0 0.7 3 8.3 0.1 3.9 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KPI84608.1 - 0.14 12.8 4.9 10 6.8 0.1 3.4 3 1 0 3 3 3 0 HMG-box domain Protamine_like PF06382.11 KPI84608.1 - 1 9.5 6.0 4.6 7.4 0.3 2.5 1 1 0 2 2 2 0 Protamine and protamine like DUF647 PF04884.14 KPI84609.1 - 5.5e-72 242.3 3.9 8.4e-72 241.7 3.9 1.3 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF3875 PF12991.7 KPI84609.1 - 0.14 12.1 0.1 0.43 10.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3875) Sec8_exocyst PF04048.14 KPI84611.1 - 7.5e-11 42.1 0.1 1.7e-10 41.0 0.1 1.6 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 KPI84611.1 - 5.2e-06 25.9 0.1 9.6e-06 25.1 0.1 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Na_trans_assoc PF06512.13 KPI84611.1 - 0.0027 18.0 2.0 0.0027 18.0 2.0 1.8 2 0 0 2 2 2 1 Sodium ion transport-associated BUD22 PF09073.10 KPI84611.1 - 0.054 12.8 10.0 0.0062 15.9 4.5 2.1 2 0 0 2 2 2 0 BUD22 Tub_N PF16322.5 KPI84611.1 - 0.45 10.9 10.0 4.1 7.7 2.3 3.1 3 0 0 3 3 3 0 Tubby N-terminal FAM176 PF14851.6 KPI84611.1 - 8.3 6.1 16.5 7.9 6.1 4.0 3.4 3 0 0 3 3 3 0 FAM176 family Ribosomal_S17_N PF16205.5 KPI84612.1 - 6.2e-28 97.0 0.3 6.2e-28 97.0 0.3 1.6 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KPI84612.1 - 1.2e-23 83.0 0.5 1.2e-23 83.0 0.5 1.9 2 0 0 2 2 2 1 Ribosomal protein S17 Cyt-b5 PF00173.28 KPI84613.1 - 2.1e-11 43.8 0.1 5.7e-09 36.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 KPI84614.1 - 1.3e-07 31.7 22.0 1.3e-07 31.7 22.0 1.9 1 1 1 2 2 2 2 Fatty acid desaturase DUF5313 PF17240.2 KPI84614.1 - 0.019 15.4 0.1 0.039 14.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5313) FlxA PF14282.6 KPI84615.1 - 0.0066 16.4 3.1 0.0066 16.4 3.1 1.3 1 1 0 1 1 1 1 FlxA-like protein Rotamase_2 PF13145.6 KPI84615.1 - 0.011 16.6 2.0 0.013 16.3 2.0 1.1 1 0 0 1 1 1 0 PPIC-type PPIASE domain Ion_trans_2 PF07885.16 KPI84616.1 - 7e-10 38.7 8.7 7e-10 38.7 8.7 2.0 2 0 0 2 2 2 1 Ion channel Ion_trans_2 PF07885.16 KPI84617.1 - 8.2e-11 41.7 4.7 8.2e-11 41.7 4.7 2.3 2 1 0 2 2 2 1 Ion channel Lig_chan PF00060.26 KPI84617.1 - 0.0015 18.4 3.3 0.029 14.2 0.8 3.0 2 1 1 3 3 3 2 Ligand-gated ion channel Ion_trans PF00520.31 KPI84617.1 - 0.025 13.8 18.6 0.055 12.7 18.4 1.7 1 1 0 1 1 1 0 Ion transport protein CaMBD PF02888.16 KPI84617.1 - 0.027 14.7 0.8 0.062 13.5 0.8 1.6 1 0 0 1 1 1 0 Calmodulin binding domain DUF5082 PF16888.5 KPI84617.1 - 0.16 12.3 1.3 1.1 9.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) WXG100 PF06013.12 KPI84617.1 - 1.4 9.2 3.5 6.4 7.1 0.3 2.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG MgtC PF02308.16 KPI84619.1 - 0.026 14.9 0.5 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 MgtC family DUF2681 PF10883.8 KPI84619.1 - 0.083 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Lectin_N PF03954.14 KPI84619.1 - 0.12 12.2 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Shisa PF13908.6 KPI84619.1 - 0.54 10.5 2.8 0.72 10.1 1.9 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Myc_target_1 PF15179.6 KPI84619.1 - 6.6 6.6 13.6 2.1 8.2 1.8 2.3 1 1 1 2 2 2 0 Myc target protein 1 WD40 PF00400.32 KPI84621.1 - 4.5e-21 74.8 23.3 0.0026 18.5 0.0 10.5 11 1 0 11 11 11 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI84621.1 - 3.1e-10 40.2 0.0 8.2 6.8 0.0 8.4 7 1 1 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 KPI84621.1 - 1.3e-07 31.9 0.2 2.5e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.8 KPI84621.1 - 0.028 13.1 0.3 5.8 5.4 0.0 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KPI84621.1 - 0.17 10.8 2.7 24 3.8 0.1 4.6 4 1 2 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Complex1_LYR PF05347.15 KPI84622.1 - 7.9e-06 25.8 0.5 1.3e-05 25.2 0.5 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KPI84622.1 - 0.0058 17.4 0.1 0.01 16.6 0.1 1.4 1 0 0 1 1 1 1 Complex1_LYR-like DEP PF00610.21 KPI84622.1 - 0.12 12.5 0.1 0.28 11.3 0.0 1.7 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SpoU_methylase PF00588.19 KPI84624.1 - 4.6e-10 39.8 0.0 0.0012 19.1 0.0 2.3 2 0 0 2 2 2 2 SpoU rRNA Methylase family PSCyt3 PF07627.11 KPI84624.1 - 0.13 12.6 0.2 0.39 11.0 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) CDC45 PF02724.14 KPI84625.1 - 0.19 10.0 0.9 0.33 9.2 0.9 1.4 1 0 0 1 1 1 0 CDC45-like protein zf-LSD1 PF06943.12 KPI84627.1 - 2.2e-07 30.6 8.4 2.2e-07 30.6 8.4 2.5 2 0 0 2 2 2 2 LSD1 zinc finger DZR PF12773.7 KPI84627.1 - 0.031 14.3 5.6 0.031 14.3 5.6 2.4 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 KPI84627.1 - 1 8.9 9.8 0.39 10.2 1.9 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 KPI84627.1 - 2.1 8.4 10.9 1.7 8.7 8.2 1.9 1 1 0 1 1 1 0 zinc-ribbons zf-Sec23_Sec24 PF04810.15 KPI84627.1 - 3.2 7.9 10.7 1.3e+03 -0.5 10.7 3.3 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger ELO PF01151.18 KPI84628.1 - 2.2e-33 115.9 7.8 2.7e-33 115.5 7.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DUF4201 PF13870.6 KPI84630.1 - 0.0014 18.4 7.3 0.0021 17.8 5.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Wap1 PF16997.5 KPI84630.1 - 0.025 13.8 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 Wap1 domain DivIC PF04977.15 KPI84630.1 - 0.087 12.6 18.3 2 8.2 0.1 3.9 3 1 1 4 4 4 0 Septum formation initiator CRA PF06589.11 KPI84630.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) ZapB PF06005.12 KPI84630.1 - 0.24 11.9 16.0 1.9 9.0 9.2 3.8 3 1 1 4 4 4 0 Cell division protein ZapB STAT_alpha PF01017.20 KPI84630.1 - 0.32 10.9 12.2 0.026 14.4 6.1 2.2 3 0 0 3 3 3 0 STAT protein, all-alpha domain Coat_F PF07875.12 KPI84630.1 - 0.46 10.7 3.3 8 6.8 0.1 2.5 2 0 0 2 2 2 0 Coat F domain GIT_CC PF16559.5 KPI84630.1 - 0.5 10.3 8.1 2.2 8.2 1.1 3.1 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Prefoldin PF02996.17 KPI84630.1 - 1.2 9.1 7.3 14 5.6 2.6 3.1 2 1 2 4 4 4 0 Prefoldin subunit YabA PF06156.13 KPI84630.1 - 1.5 9.5 7.7 2 9.1 2.3 3.0 3 1 1 4 4 4 0 Initiation control protein YabA FlxA PF14282.6 KPI84630.1 - 3.5 7.7 9.9 2.5 8.1 1.8 3.6 4 0 0 4 4 4 0 FlxA-like protein TMF_DNA_bd PF12329.8 KPI84630.1 - 5.1 7.2 11.0 3.5 7.7 0.0 4.0 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 KPI84630.1 - 5.5 5.8 14.5 0.51 9.2 8.5 2.2 3 0 0 3 3 3 0 Spc7 kinetochore protein BRE1 PF08647.11 KPI84630.1 - 9.6 6.4 12.3 3.1 7.9 1.1 3.6 4 0 0 4 4 4 0 BRE1 E3 ubiquitin ligase SET PF00856.28 KPI84631.1 - 1.6e-06 28.6 0.0 2.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 SET domain Proteasome PF00227.26 KPI84632.1 - 1.1e-48 165.3 0.6 1.3e-48 165.0 0.6 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 KPI84632.1 - 0.0046 16.3 0.1 0.0046 16.3 0.1 2.3 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Cobalamin_bind PF01122.19 KPI84632.1 - 0.095 11.6 0.2 0.32 9.8 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic cobalamin-binding protein sCache_2 PF17200.4 KPI84632.1 - 0.15 11.9 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Single Cache domain 2 Ribosomal_S17 PF00366.20 KPI84633.1 - 9.8e-18 64.0 0.4 1.9e-17 63.1 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Cpn60_TCP1 PF00118.24 KPI84634.1 - 5.2e-157 523.4 1.9 6.5e-157 523.1 1.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NDK PF00334.19 KPI84635.1 - 9.7e-32 109.8 0.0 3.1e-29 101.7 0.0 2.3 1 1 1 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.12 KPI84635.1 - 4.9e-06 26.3 0.0 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 DUF1126 PH-like domain WD40 PF00400.32 KPI84636.1 - 2.8e-28 97.6 16.0 8e-08 32.8 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat Sof1 PF04158.14 KPI84636.1 - 1.2e-09 38.3 7.0 2.3e-09 37.4 7.0 1.4 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 KPI84636.1 - 9.1e-06 25.9 0.1 0.06 13.6 0.0 4.3 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KPI84636.1 - 0.00046 20.1 0.0 0.0016 18.3 0.0 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 KPI84636.1 - 0.094 11.2 1.2 0.28 9.6 0.1 2.2 3 0 0 3 3 3 0 Cytochrome D1 heme domain WD40_like PF17005.5 KPI84636.1 - 0.12 11.7 0.0 2 7.7 0.0 2.6 4 0 0 4 4 4 0 WD40-like domain Nup160 PF11715.8 KPI84636.1 - 0.13 10.8 6.8 6.3 5.3 0.1 3.8 3 2 1 4 4 4 0 Nucleoporin Nup120/160 EF-hand_1 PF00036.32 KPI84637.1 - 1.6e-09 36.7 1.8 4.8e-08 32.0 0.1 3.4 3 1 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 KPI84637.1 - 1.7e-09 37.3 1.7 4.6e-06 26.4 0.2 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KPI84637.1 - 4.7e-09 36.6 0.9 4e-07 30.4 1.7 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI84637.1 - 7.3e-09 34.9 0.2 3.4e-06 26.5 0.0 3.5 3 1 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KPI84637.1 - 0.00014 21.2 0.0 0.00014 21.2 0.0 2.6 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 KPI84637.1 - 0.00033 20.9 0.1 0.25 11.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 KPI84637.1 - 0.025 14.6 0.0 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Mre11_DNA_bind PF04152.14 KPI84638.1 - 0.089 13.1 0.3 1.2 9.4 0.2 2.1 2 0 0 2 2 2 0 Mre11 DNA-binding presumed domain GPW_gp25 PF04965.14 KPI84638.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Gene 25-like lysozyme DJ-1_PfpI PF01965.24 KPI84639.1 - 1.1e-43 149.0 0.0 1.2e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 KPI84639.1 - 4.3e-05 23.4 0.0 6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ThiJ_like PF17124.5 KPI84639.1 - 0.025 14.2 0.1 0.23 11.1 0.1 2.3 1 1 0 1 1 1 0 ThiJ/PfpI family-like Peptidase_C26 PF07722.13 KPI84639.1 - 0.085 12.6 0.1 0.21 11.3 0.1 1.7 1 1 0 1 1 1 0 Peptidase C26 PPTA PF01239.22 KPI84640.1 - 0.13 12.1 0.4 0.38 10.6 0.4 1.8 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat DUF2116 PF09889.9 KPI84640.1 - 0.2 11.7 3.9 0.098 12.7 0.8 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) SHIPPO-rpt PF07004.12 KPI84641.1 - 4.9e-13 49.3 48.2 0.009 16.9 0.2 10.2 10 0 0 10 10 10 9 Sperm-tail PG-rich repeat UNC-50 PF05216.13 KPI84642.1 - 9.4e-52 175.8 9.0 1.1e-51 175.5 9.0 1.0 1 0 0 1 1 1 1 UNC-50 family GRIP PF01465.20 KPI84642.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 GRIP domain INCENP_N PF12178.8 KPI84643.1 - 0.0055 16.7 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Chromosome passenger complex (CPC) protein INCENP N terminal PROCN PF08083.11 KPI84644.1 - 4.2e-189 628.5 5.2 1e-188 627.2 5.2 1.6 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 KPI84644.1 - 7.3e-91 303.9 0.0 1.2e-90 303.2 0.0 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 KPI84644.1 - 3.5e-68 228.6 0.1 7.9e-68 227.4 0.1 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 KPI84644.1 - 1.4e-59 200.4 0.0 3.8e-59 199.0 0.0 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 KPI84644.1 - 6.4e-59 197.8 0.1 1.4e-58 196.7 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 KPI84644.1 - 1.3e-36 124.7 0.1 5e-36 122.9 0.1 2.1 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 KPI84644.1 - 5.5e-29 100.6 0.0 1.2e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain DUF5480 PF17576.2 KPI84644.1 - 0.11 12.4 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5480) CPSase_L_D2 PF02786.17 KPI84644.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Herpes_UL87 PF03043.14 KPI84646.1 - 0.085 11.3 0.0 0.092 11.2 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL87 family Kelch_3 PF13415.6 KPI84646.1 - 0.13 12.6 0.2 0.29 11.5 0.2 1.7 1 0 0 1 1 1 0 Galactose oxidase, central domain HD-ZIP_N PF04618.12 KPI84646.1 - 2.7 8.6 6.5 21 5.7 0.7 2.6 1 1 2 3 3 3 0 HD-ZIP protein N terminus KH_6 PF15985.5 KPI84647.1 - 4.2e-09 36.6 0.0 1.1e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 KH domain INTS5_N PF14837.6 KPI84648.1 - 0.14 11.7 0.3 0.23 11.0 0.3 1.2 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus Viral_alk_exo PF01771.17 KPI84648.1 - 0.38 9.6 2.3 0.53 9.1 2.3 1.1 1 0 0 1 1 1 0 Viral alkaline exonuclease IFT57 PF10498.9 KPI84649.1 - 0.11 11.5 2.0 0.16 10.9 2.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 MarR_2 PF12802.7 KPI84650.1 - 0.0072 16.2 0.1 0.049 13.5 0.1 2.6 1 0 0 1 1 1 1 MarR family THOC7 PF05615.13 KPI84651.1 - 0.0092 16.3 0.1 0.012 15.8 0.1 1.3 1 0 0 1 1 1 1 Tho complex subunit 7 ABC_tran_CTD PF16326.5 KPI84651.1 - 0.17 12.2 1.7 0.28 11.5 1.7 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain DprA_WH PF17782.1 KPI84651.1 - 0.36 11.0 4.7 6.8 6.9 0.0 3.2 2 1 1 3 3 3 0 DprA winged helix domain Methyltransf_31 PF13847.6 KPI84652.1 - 5.5e-06 26.3 0.0 7.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84652.1 - 0.00053 20.6 0.1 0.0013 19.4 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI84652.1 - 0.023 15.3 0.0 0.044 14.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Topo_C_assoc PF14370.6 KPI84653.1 - 1.3e-28 98.8 0.3 1.8e-28 98.2 0.3 1.2 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF4171 PF13775.6 KPI84653.1 - 0.0047 17.4 12.1 0.0072 16.8 12.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4171) AF-4 PF05110.13 KPI84653.1 - 0.022 12.9 20.5 0.025 12.7 20.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SPX PF03105.19 KPI84653.1 - 0.085 12.8 11.4 0.1 12.5 11.4 1.2 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 KPI84653.1 - 0.14 10.6 10.3 0.19 10.3 10.3 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 KPI84653.1 - 0.2 9.9 11.1 0.23 9.7 11.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.9 KPI84653.1 - 0.43 9.4 9.3 0.49 9.2 9.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AKAP2_C PF15304.6 KPI84653.1 - 1.8 7.8 15.2 2.7 7.2 15.2 1.3 1 1 0 1 1 1 0 A-kinase anchor protein 2 C-terminus Presenilin PF01080.17 KPI84653.1 - 4.1 6.1 4.6 5 5.8 4.6 1.1 1 0 0 1 1 1 0 Presenilin Hamartin PF04388.12 KPI84653.1 - 8 5.0 12.9 9 4.8 12.9 1.1 1 0 0 1 1 1 0 Hamartin protein Torus PF16131.5 KPI84656.1 - 6.4 7.5 10.6 2.9 8.6 4.0 2.6 2 0 0 2 2 2 0 Torus domain PDEase_I PF00233.19 KPI84658.1 - 6.1e-20 72.0 0.0 9e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF4942 PF13708.6 KPI84658.1 - 0.061 13.3 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4942) E1-E2_ATPase PF00122.20 KPI84659.1 - 2.3e-47 160.8 0.3 2.3e-47 160.8 0.3 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KPI84659.1 - 2.6e-45 154.4 5.8 2.6e-45 154.4 5.8 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KPI84659.1 - 1.9e-20 74.1 2.3 1.5e-19 71.1 2.3 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KPI84659.1 - 1.1e-17 63.4 0.5 2.6e-17 62.2 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KPI84659.1 - 1e-16 60.8 0.2 2.9e-16 59.3 0.2 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KPI84659.1 - 1.8e-07 31.2 2.5 3.3e-06 27.1 1.3 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI84659.1 - 0.0004 20.9 0.0 0.0021 18.5 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF281 PF03436.13 KPI84659.1 - 0.014 15.8 0.2 0.7 10.3 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF281) DUF4165 PF13752.6 KPI84659.1 - 0.077 13.0 0.0 0.28 11.2 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4165) FTO_CTD PF12934.7 KPI84661.1 - 0.059 13.1 3.3 0.11 12.2 0.3 2.2 2 0 0 2 2 2 0 FTO C-terminal domain Roc PF08477.13 KPI84662.1 - 5.3e-09 36.3 0.0 3.2e-08 33.8 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KPI84662.1 - 1.1e-06 28.1 0.1 0.019 14.1 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 KPI84662.1 - 1.3e-06 28.0 0.2 0.00011 21.8 0.2 2.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI84662.1 - 0.00043 20.3 0.0 0.00074 19.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 KPI84662.1 - 0.00049 19.7 0.0 0.0026 17.4 0.0 2.1 2 1 0 2 2 2 1 Ras family Dynamin_N PF00350.23 KPI84662.1 - 0.0016 18.5 0.0 0.0049 17.0 0.0 1.7 1 1 1 2 2 2 1 Dynamin family Septin PF00735.18 KPI84662.1 - 0.0038 16.6 0.0 0.0054 16.0 0.0 1.2 1 0 0 1 1 1 1 Septin Gtr1_RagA PF04670.12 KPI84662.1 - 0.0057 16.0 0.0 0.049 13.0 0.0 2.2 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 KPI84662.1 - 0.021 14.5 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KPI84662.1 - 0.05 14.1 0.1 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KPI84662.1 - 0.07 12.2 0.1 0.095 11.7 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein PduV-EutP PF10662.9 KPI84662.1 - 0.081 12.7 0.0 0.41 10.4 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 KPI84662.1 - 0.16 12.5 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter IATP PF04568.12 KPI84663.1 - 0.17 12.3 1.4 16 6.0 0.0 3.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP zf-XS PF03470.14 KPI84663.1 - 8.4 6.7 5.3 4.4 7.7 1.3 2.5 2 0 0 2 2 2 0 XS zinc finger domain COG5 PF10392.9 KPI84664.1 - 1.9e-12 47.5 2.1 1.9e-12 47.5 2.1 4.5 5 1 1 6 6 6 1 Golgi transport complex subunit 5 Dor1 PF04124.12 KPI84664.1 - 0.04 12.6 4.0 0.038 12.7 2.1 1.9 2 0 0 2 2 2 0 Dor1-like family CbiJ PF02571.14 KPI84664.1 - 0.06 12.8 1.4 0.13 11.7 1.4 1.5 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK L51_S25_CI-B8 PF05047.16 KPI84666.1 - 0.0051 16.7 0.1 0.0081 16.1 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain LRR_6 PF13516.6 KPI84667.1 - 2.8e-10 39.4 6.7 0.032 14.3 0.0 5.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KPI84667.1 - 2.5e-06 27.7 1.9 0.0031 17.9 1.3 3.7 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI84667.1 - 0.0011 18.7 4.0 0.01 15.6 0.7 3.2 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.33 KPI84667.1 - 0.016 15.6 0.1 37 5.4 0.1 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat IQ PF00612.27 KPI84668.1 - 1.5e-12 46.1 94.0 0.0004 19.9 2.8 11.5 11 0 0 11 11 11 7 IQ calmodulin-binding motif TPR_10 PF13374.6 KPI84668.1 - 1.4e-08 34.4 8.0 0.0012 18.6 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84668.1 - 1.2e-06 28.7 1.2 0.0007 19.8 0.2 6.7 5 2 2 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84668.1 - 1.1e-05 25.2 0.3 2 8.7 0.0 5.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI84668.1 - 0.016 15.2 3.8 1.2 9.3 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3439 PF11921.8 KPI84668.1 - 0.88 9.6 6.9 2 8.4 6.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 KPI84668.1 - 9.7 4.0 9.3 15 3.4 9.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Aldedh PF00171.22 KPI84669.1 - 2.2e-11 42.9 2.1 2.7e-07 29.5 0.6 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family RPN1_RPN2_N PF17781.1 KPI84670.1 - 6.5e-76 255.7 0.4 1.1e-75 254.9 0.4 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 KPI84670.1 - 9.3e-22 76.3 16.0 0.0002 21.6 0.0 8.6 9 0 0 9 9 9 5 Proteasome/cyclosome repeat RPN1_C PF18051.1 KPI84670.1 - 2.6e-17 62.6 0.0 4.9e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal HEAT_2 PF13646.6 KPI84670.1 - 0.00095 19.5 4.7 0.06 13.7 0.2 4.4 3 1 1 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 KPI84670.1 - 0.19 12.2 1.7 1.9 9.1 0.1 3.4 3 0 0 3 3 3 0 HEAT-like repeat IFRD PF05004.13 KPI84670.1 - 0.22 10.6 2.4 0.29 10.2 0.8 2.1 2 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TFB6 PF17110.5 KPI84670.1 - 0.83 9.4 3.1 1.4 8.7 0.0 2.8 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH IQ PF00612.27 KPI84671.1 - 0.0056 16.4 11.6 0.01 15.6 2.8 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif PGM1_C PF18105.1 KPI84671.1 - 0.1 12.2 1.5 0.31 10.6 0.0 2.5 2 0 0 2 2 2 0 PGM1 C-terminal domain RNA_pol_A_bac PF01000.26 KPI84672.1 - 9.4e-19 67.8 0.0 2e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KPI84672.1 - 1e-15 56.9 0.0 1.5e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 KPI84672.1 - 0.058 13.6 1.1 0.058 13.6 1.1 2.0 2 0 0 2 2 2 0 4Fe-4S dicluster domain TPR_19 PF14559.6 KPI84673.1 - 8.9e-15 55.0 11.3 1.8e-05 25.2 0.8 5.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84673.1 - 5.9e-13 47.9 18.8 0.00021 21.1 0.3 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI84673.1 - 1.9e-11 44.0 13.3 9.4e-07 29.0 5.0 3.9 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 KPI84673.1 - 1.1e-09 37.6 17.3 0.022 14.6 0.9 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI84673.1 - 2.1e-09 37.5 13.6 0.0088 16.3 2.0 7.4 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI84673.1 - 3.2e-08 34.1 2.2 5.3e-05 23.8 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI84673.1 - 2.1e-07 30.5 3.0 4.4 7.6 0.2 6.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84673.1 - 3.2e-07 30.6 8.0 0.024 15.5 0.1 6.6 6 2 2 8 8 6 2 Tetratricopeptide repeat SRP_TPR_like PF17004.5 KPI84673.1 - 0.00052 20.0 17.0 0.098 12.7 0.1 4.8 3 2 3 6 6 6 3 Putative TPR-like repeat HrpB1_HrpK PF09613.10 KPI84673.1 - 0.0021 17.7 1.4 0.33 10.6 0.0 3.7 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) Foie-gras_1 PF11817.8 KPI84673.1 - 0.0039 16.8 5.9 0.44 10.1 1.0 2.9 1 1 1 2 2 2 2 Foie gras liver health family 1 TPR_20 PF14561.6 KPI84673.1 - 0.011 16.1 0.2 9.7 6.6 0.0 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat tRNA-synt_His PF13393.6 KPI84673.1 - 0.011 15.0 0.1 1.4 8.1 0.0 2.6 2 0 0 2 2 2 0 Histidyl-tRNA synthetase Fis1_TPR_C PF14853.6 KPI84673.1 - 0.012 15.7 11.3 8.6 6.5 0.1 4.8 2 1 2 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_3 PF07720.12 KPI84673.1 - 0.013 15.5 1.4 0.013 15.5 1.4 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI84673.1 - 0.033 14.4 16.0 5.7 7.4 0.0 6.9 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI84673.1 - 0.081 13.1 0.4 13 6.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 KPI84673.1 - 0.087 13.1 8.3 13 6.3 0.0 4.9 5 0 0 5 5 4 0 PPR repeat TPR_MalT PF17874.1 KPI84673.1 - 0.22 10.9 4.3 8.9 5.6 0.0 4.1 3 2 0 4 4 4 0 MalT-like TPR region TPR_11 PF13414.6 KPI84673.1 - 0.22 11.2 14.0 1.2 8.9 0.6 4.6 5 1 0 5 5 5 0 TPR repeat PSII_Pbs31 PF18240.1 KPI84673.1 - 0.65 10.5 2.6 1.3 9.5 0.6 2.4 2 0 0 2 2 2 0 Photosystem II Psb31 protein TPR_6 PF13174.6 KPI84673.1 - 0.95 10.2 26.5 0.056 14.1 2.1 7.5 10 0 0 10 10 8 0 Tetratricopeptide repeat BTAD PF03704.17 KPI84673.1 - 1.7 9.1 5.4 1 9.8 0.4 2.7 3 0 0 3 3 2 0 Bacterial transcriptional activator domain IPP-2 PF04979.14 KPI84675.1 - 5e-22 79.1 10.1 6.2e-22 78.7 10.1 1.0 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF3987 PF13148.6 KPI84675.1 - 0.034 13.2 1.1 0.045 12.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) zf-RanBP PF00641.18 KPI84676.1 - 0.0063 15.8 5.7 0.0063 15.8 5.7 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others SRRM_C PF15230.6 KPI84676.1 - 2.2 8.9 16.3 7 7.3 16.3 1.8 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus SNF2_N PF00176.23 KPI84678.1 - 5.9e-31 107.5 0.1 1e-30 106.7 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI84678.1 - 3.5e-10 40.2 0.0 6.8e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI84678.1 - 1.2e-06 28.7 0.0 2.3e-05 24.5 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 KPI84678.1 - 2.1e-05 24.3 0.1 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 KPI84678.1 - 0.0076 16.5 0.5 0.16 12.2 0.1 3.2 3 0 0 3 3 3 1 AAA domain Zn_Tnp_IS91 PF14319.6 KPI84678.1 - 0.013 15.6 0.5 0.033 14.2 0.5 1.7 1 0 0 1 1 1 0 Transposase zinc-binding domain ERCC3_RAD25_C PF16203.5 KPI84678.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-LSD1 PF06943.12 KPI84678.1 - 1.7 8.6 6.6 1.2 9.0 3.9 2.3 2 0 0 2 2 2 0 LSD1 zinc finger DUF2207 PF09972.9 KPI84679.1 - 0.05 12.4 2.9 0.12 11.1 2.9 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Sec23_trunk PF04811.15 KPI84680.1 - 1e-42 146.4 0.0 1.7e-42 145.7 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KPI84680.1 - 1.4e-20 73.9 0.0 2.9e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KPI84680.1 - 6.5e-12 45.3 1.6 1.5e-11 44.1 1.6 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 KPI84680.1 - 2.4e-11 43.3 0.0 6.5e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain DNA_RNApol_7kD PF03604.13 KPI84680.1 - 0.064 13.0 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Sen15 PF09631.10 KPI84680.1 - 0.12 12.7 0.0 0.4 11.0 0.0 1.8 1 0 0 1 1 1 0 Sen15 protein Alpha_E3_glycop PF01563.16 KPI84680.1 - 0.21 11.7 1.5 6.8 6.8 0.0 3.4 3 0 0 3 3 3 0 Alphavirus E3 glycoprotein Gelsolin PF00626.22 KPI84680.1 - 0.26 11.2 1.8 0.6 10.1 0.0 2.5 3 0 0 3 3 3 0 Gelsolin repeat RIO1 PF01163.22 KPI84682.1 - 1.2e-64 217.4 0.0 2.1e-64 216.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KPI84682.1 - 0.072 11.9 0.1 0.072 11.9 0.1 1.6 2 0 0 2 2 2 0 Fungal protein kinase CDC45 PF02724.14 KPI84682.1 - 1.2 7.3 10.3 1.8 6.8 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 KPI84683.1 - 1e-69 234.8 0.0 1.2e-69 234.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84683.1 - 5.7e-31 107.7 0.0 1.3e-30 106.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI84683.1 - 2e-07 30.6 0.1 4e-06 26.4 0.0 2.1 1 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KPI84683.1 - 0.015 15.0 0.0 0.027 14.1 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 KPI84683.1 - 0.016 14.3 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 KPI84683.1 - 0.016 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KPI84683.1 - 0.076 12.4 0.1 0.16 11.3 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ferritin PF00210.24 KPI84685.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Ferritin-like domain RRM_1 PF00076.22 KPI84686.1 - 1.1e-77 255.8 5.7 9.1e-21 73.5 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KPI84686.1 - 1.4e-19 70.0 0.1 1.4e-18 66.8 0.0 2.3 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KPI84686.1 - 2.2e-09 37.0 0.4 5.6e-05 22.7 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 KPI84686.1 - 2.6e-05 24.1 0.1 0.18 11.6 0.1 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF4523) Nup35_RRM_2 PF14605.6 KPI84686.1 - 4.8e-05 23.3 0.9 1.3 9.1 0.0 4.1 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KPI84686.1 - 7.7e-05 22.7 1.9 10 6.2 0.0 4.3 4 0 0 4 4 4 2 RNA binding motif RRM_8 PF11835.8 KPI84686.1 - 0.00031 20.9 0.0 2.4 8.5 0.0 3.4 3 0 0 3 3 3 2 RRM-like domain RRM_occluded PF16842.5 KPI84686.1 - 0.00076 19.3 0.3 26 4.7 0.1 4.1 4 0 0 4 4 4 0 Occluded RNA-recognition motif RRM_7 PF16367.5 KPI84686.1 - 0.0038 17.3 0.8 9.4 6.4 0.0 3.9 4 2 0 4 4 4 2 RNA recognition motif SET_assoc PF11767.8 KPI84686.1 - 0.0041 16.7 2.1 3.2 7.4 0.1 3.6 4 0 0 4 4 4 2 Histone lysine methyltransferase SET associated RNA_bind PF08675.11 KPI84686.1 - 0.056 13.5 0.1 2.3 8.3 0.0 3.4 4 0 0 4 4 4 0 RNA binding domain Pkinase_C PF00433.24 KPI84686.1 - 0.11 13.2 0.0 0.39 11.5 0.0 2.0 1 0 0 1 1 1 0 Protein kinase C terminal domain SMN PF06003.12 KPI84686.1 - 0.54 9.5 7.2 1 8.6 7.2 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) XS PF03468.14 KPI84686.1 - 2 8.8 4.6 27 5.1 0.2 3.4 3 1 1 4 4 4 0 XS domain UCH PF00443.29 KPI84688.1 - 7e-37 127.3 0.0 1.1e-36 126.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 KPI84688.1 - 1.2e-15 56.9 5.6 1.2e-15 56.9 5.6 3.1 3 0 0 3 3 3 2 Variant UBP zinc finger zf-UBP PF02148.19 KPI84688.1 - 3.4e-15 56.1 7.6 3.4e-15 56.1 7.6 3.4 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 KPI84688.1 - 1.4e-13 51.1 0.1 3e-12 46.8 0.0 2.5 2 1 1 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 KPI84688.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain ECH_1 PF00378.20 KPI84689.1 - 6.3e-74 248.5 0.4 7.2e-74 248.3 0.4 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI84689.1 - 4.8e-39 134.8 0.4 6e-35 121.3 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 KPI84689.1 - 0.0089 16.0 0.1 2.2 8.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase family S49 Pkinase PF00069.25 KPI84690.1 - 8.3e-57 192.5 0.0 1.2e-56 192.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84690.1 - 5.5e-35 120.9 0.0 9.2e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI84690.1 - 4.5e-05 23.5 0.0 0.025 14.5 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI84690.1 - 7.9e-05 21.8 0.2 0.0053 15.7 0.0 2.8 2 1 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KPI84690.1 - 0.00024 20.0 0.0 0.00045 19.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Ig_6 PF18452.1 KPI84690.1 - 0.19 11.3 0.1 0.39 10.3 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain ToxB_N PF18224.1 KPI84691.1 - 0.098 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 ToxB N-terminal domain PIN_8 PF18476.1 KPI84691.1 - 0.15 11.9 0.5 0.32 10.8 0.1 1.7 2 0 0 2 2 2 0 PIN like domain NAP PF00956.18 KPI84692.1 - 0.00037 19.8 4.3 0.54 9.4 0.0 3.0 1 1 2 3 3 3 3 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.12 KPI84692.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.3 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein COQ7 PF03232.13 KPI84693.1 - 7e-55 185.4 1.4 8e-55 185.2 1.4 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 AlaDh_PNT_C PF01262.21 KPI84693.1 - 0.053 12.8 0.0 0.074 12.3 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Peptidase_M18 PF02127.15 KPI84694.1 - 1.5e-156 521.6 0.0 1.7e-156 521.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KPI84694.1 - 4.4e-09 35.8 0.2 5.3e-06 25.7 0.1 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase End_beta_barrel PF12195.8 KPI84694.1 - 0.0065 16.4 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Beta barrel domain of bacteriophage endosialidase Glutaredoxin PF00462.24 KPI84695.1 - 9.7e-15 54.5 0.3 1.2e-14 54.2 0.3 1.1 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 KPI84695.1 - 6e-06 26.2 0.1 7.4e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain GST_N_3 PF13417.6 KPI84695.1 - 0.00019 21.7 0.0 0.00021 21.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_4 PF13462.6 KPI84695.1 - 0.00095 19.4 0.2 1.3 9.2 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin DUF836 PF05768.14 KPI84695.1 - 0.0028 18.0 0.1 0.0033 17.8 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 KPI84695.1 - 0.0057 17.1 0.3 0.0073 16.7 0.3 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 KPI84695.1 - 0.0083 15.9 0.2 0.7 9.6 0.2 2.1 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Beta_helix PF13229.6 KPI84696.1 - 6.8e-86 286.0 113.7 9.8e-15 54.7 6.7 17.7 11 4 6 17 17 17 14 Right handed beta helix region NosD PF05048.13 KPI84696.1 - 2.1e-66 223.6 51.9 7.3e-14 51.6 0.8 14.7 10 5 1 13 13 13 10 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 KPI84696.1 - 0.08 12.3 0.0 0.08 12.3 0.0 12.0 11 2 1 14 14 14 0 Protein of unknown function (DUF1565) FliJ PF02050.16 KPI84696.1 - 0.15 12.3 0.3 0.34 11.1 0.3 1.6 1 0 0 1 1 1 0 Flagellar FliJ protein GARP PF16731.5 KPI84696.1 - 1.1 8.9 5.7 25 4.5 2.1 3.0 3 0 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma Urb2 PF10441.9 KPI84698.1 - 2.3 8.1 5.7 1.3 8.9 0.7 2.7 2 1 0 2 2 2 0 Urb2/Npa2 family WD40 PF00400.32 KPI84700.1 - 8.9e-05 23.2 8.8 0.0044 17.8 0.0 6.6 7 0 0 7 7 7 1 WD domain, G-beta repeat Nup160 PF11715.8 KPI84700.1 - 0.024 13.3 0.5 0.057 12.0 0.2 1.7 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Frtz PF11768.8 KPI84700.1 - 0.074 11.4 0.1 1.4 7.2 0.0 2.5 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz PHTB1_N PF14727.6 KPI84700.1 - 0.14 11.5 0.0 7.2 5.9 0.0 2.8 3 0 0 3 3 3 0 PTHB1 N-terminus PQQ_3 PF13570.6 KPI84700.1 - 0.27 11.8 3.4 14 6.3 0.0 4.8 6 0 0 6 6 6 0 PQQ-like domain DUF1126 PF06565.12 KPI84701.1 - 3.2e-78 258.3 0.5 1.6e-24 85.7 0.1 3.3 3 0 0 3 3 3 3 DUF1126 PH-like domain EF-hand_7 PF13499.6 KPI84701.1 - 1.4e-06 28.6 2.9 2e-05 24.9 0.1 3.3 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 KPI84701.1 - 0.00014 21.6 0.3 0.0023 17.7 0.1 2.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI84701.1 - 0.0051 16.6 0.1 34 4.7 0.0 4.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KPI84701.1 - 0.011 15.3 0.1 10 5.9 0.0 4.3 4 0 0 4 4 4 0 EF hand Sep15_SelM PF08806.11 KPI84702.1 - 0.047 13.9 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 Sep15/SelM redox domain zf-C3HC PF07967.13 KPI84702.1 - 0.066 13.3 0.6 0.11 12.6 0.6 1.3 1 0 0 1 1 1 0 C3HC zinc finger-like MalM PF07148.12 KPI84702.1 - 0.078 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Maltose operon periplasmic protein precursor (MalM) E1_dh PF00676.20 KPI84703.1 - 2.7e-52 177.6 0.0 4.1e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 KPI84703.1 - 8e-50 169.0 0.0 1.4e-49 168.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 KPI84703.1 - 4.5e-35 120.6 0.0 1.4e-34 119.0 0.0 1.9 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KPI84703.1 - 0.00016 21.2 0.2 0.00049 19.6 0.2 1.9 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus PIP5K PF01504.18 KPI84704.1 - 2.1e-35 122.3 0.0 5.4e-25 88.2 0.0 3.1 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase FYVE PF01363.21 KPI84704.1 - 1.6e-16 60.2 3.2 3.7e-16 59.0 3.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger Cpn60_TCP1 PF00118.24 KPI84704.1 - 0.00011 21.0 0.0 0.00017 20.4 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family IBR PF01485.21 KPI84704.1 - 0.21 11.8 5.0 0.66 10.2 5.0 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF778 PF05608.12 KPI84705.1 - 3.5e-31 109.0 4.7 3.1e-19 70.1 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) Peptidase_C97 PF05903.14 KPI84705.1 - 0.028 14.3 0.3 0.04 13.8 0.3 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain Gln_deamidase_2 PF18626.1 KPI84705.1 - 0.068 13.4 0.2 0.11 12.7 0.2 1.3 1 0 0 1 1 1 0 Glutaminase DUF4796 PF16044.5 KPI84705.1 - 0.12 11.9 0.6 0.49 10.0 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4796) Amastin PF07344.11 KPI84706.1 - 0.00034 20.5 10.6 0.00043 20.1 10.6 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein DUF624 PF04854.14 KPI84706.1 - 0.3 11.2 13.4 2.3 8.4 7.2 2.8 2 1 0 2 2 2 0 Protein of unknown function, DUF624 SUR7 PF06687.12 KPI84706.1 - 1 8.9 11.2 0.16 11.5 6.6 1.9 2 0 0 2 2 2 0 SUR7/PalI family Amastin PF07344.11 KPI84708.1 - 0.0063 16.4 12.9 0.0063 16.4 12.9 2.2 1 1 2 3 3 3 1 Amastin surface glycoprotein Amastin PF07344.11 KPI84710.1 - 7.7e-08 32.3 3.8 7.7e-08 32.3 3.8 1.6 2 0 0 2 2 2 1 Amastin surface glycoprotein DUF2157 PF09925.9 KPI84710.1 - 0.044 13.6 1.9 0.098 12.4 1.9 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) RuvB_N PF05496.12 KPI84711.1 - 0.082 12.7 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DHO_dh PF01180.21 KPI84713.1 - 5.8e-67 226.0 0.0 6.6e-67 225.8 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 KPI84713.1 - 0.016 14.3 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 FMN-dependent dehydrogenase OTCace_N PF02729.21 KPI84714.1 - 5.8e-39 133.5 0.3 8.6e-39 132.9 0.3 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 KPI84714.1 - 1.7e-30 106.2 0.0 5.4e-30 104.6 0.0 1.7 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain DUF3653 PF12375.8 KPI84714.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Phage protein OMPdecase PF00215.24 KPI84715.1 - 1e-35 123.4 0.0 1.7e-35 122.7 0.0 1.4 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 KPI84715.1 - 2.2e-17 63.0 0.1 5.3e-17 61.8 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KPI84715.1 - 0.0029 17.1 0.0 0.0053 16.2 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 KPI84715.1 - 0.0046 16.5 0.0 0.0086 15.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase Sugar_tr PF00083.24 KPI84716.1 - 4.5e-67 226.9 30.7 8.4e-38 130.4 18.2 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KPI84716.1 - 2.6e-15 56.2 37.3 1.5e-14 53.7 32.7 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily NiFe_hyd_3_EhaA PF17367.2 KPI84716.1 - 1.3 9.3 8.7 0.052 13.7 1.5 2.4 3 0 0 3 3 3 0 NiFe-hydrogenase-type-3 Eha complex subunit A Sugar_tr PF00083.24 KPI84717.1 - 1.4e-80 271.4 32.6 1.2e-41 143.1 24.0 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KPI84717.1 - 4.8e-15 55.3 34.5 1.4e-13 50.6 30.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 KPI84717.1 - 0.0018 16.6 0.7 0.0037 15.6 0.3 1.6 2 0 0 2 2 2 1 BT1 family AAA_18 PF13238.6 KPI84718.1 - 3.6e-05 24.3 0.1 0.00074 20.1 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI84718.1 - 0.028 14.6 0.0 0.07 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 KPI84718.1 - 0.09 12.5 0.0 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Pkinase PF00069.25 KPI84719.1 - 3.7e-58 197.0 0.0 4.3e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84719.1 - 2.8e-22 79.2 0.0 3.9e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 KPI84719.1 - 0.012 15.3 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 KPI84719.1 - 0.017 15.0 0.7 0.057 13.3 0.1 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 KPI84719.1 - 0.15 11.4 0.0 0.32 10.3 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LTXXQ PF07813.12 KPI84720.1 - 7 7.4 6.7 0.7 10.6 0.7 2.4 3 0 0 3 3 3 0 LTXXQ motif family protein CoaE PF01121.20 KPI84721.1 - 2.4e-19 69.7 0.1 9.9e-05 22.1 0.0 4.1 3 1 0 4 4 4 4 Dephospho-CoA kinase NTF2 PF02136.20 KPI84722.1 - 3.7e-09 37.2 0.0 5.8e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF1699 PF08004.11 KPI84722.1 - 0.098 12.3 0.0 2.8 7.6 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1699) TMEM52 PF14979.6 KPI84722.1 - 2.5 8.0 4.8 1.4 8.9 1.4 2.1 1 1 1 2 2 2 0 Transmembrane 52 DUF4379 PF14311.6 KPI84724.1 - 6.5e-18 64.8 9.3 5.6e-09 36.2 1.6 3.0 3 1 0 3 3 3 2 Probable Zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 KPI84724.1 - 0.0042 17.0 10.1 0.0057 16.6 2.2 3.3 3 0 0 3 3 3 1 Transposase zinc-ribbon domain DUF5313 PF17240.2 KPI84724.1 - 0.057 13.8 0.1 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5313) Zn_ribbon_recom PF13408.6 KPI84724.1 - 0.11 13.0 8.3 2.2 8.8 0.8 2.6 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-IS66 PF13005.7 KPI84724.1 - 0.18 12.2 6.3 3.9 8.0 0.0 3.6 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 zf-HC5HC2H PF13771.6 KPI84724.1 - 0.22 11.8 5.5 0.63 10.3 0.3 2.7 2 1 0 3 3 3 0 PHD-like zinc-binding domain Zn_Tnp_IS91 PF14319.6 KPI84724.1 - 3.5 7.7 10.2 0.88 9.6 0.8 2.9 3 0 0 3 3 3 0 Transposase zinc-binding domain DnaJ PF00226.31 KPI84725.1 - 2.2e-15 56.5 0.5 5.1e-15 55.4 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain FAM221 PF14753.6 KPI84726.1 - 6.1e-15 55.3 13.8 2.3e-12 46.9 0.2 3.4 4 0 0 4 4 4 3 Protein FAM221A/B NOB1_Zn_bind PF08772.11 KPI84726.1 - 0.002 18.2 1.4 0.002 18.2 1.4 2.3 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like ATP12 PF07542.11 KPI84727.1 - 1.6e-18 67.1 0.0 3.1e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein DUF1654 PF07867.11 KPI84727.1 - 0.15 11.8 0.2 0.3 10.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) Peptidase_C13 PF01650.18 KPI84728.1 - 9.7e-38 130.1 0.0 1.2e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family TTL PF03133.15 KPI84729.1 - 3e-76 256.4 0.0 4.3e-76 255.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KPI84729.1 - 7.2e-05 22.2 0.0 0.0073 15.6 0.0 2.6 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KPI84729.1 - 0.016 14.5 0.0 0.046 13.0 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp DUF3884 PF13024.6 KPI84729.1 - 0.13 11.9 0.0 0.36 10.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) APOBEC3 PF18771.1 KPI84730.1 - 0.002 18.2 0.2 0.31 11.2 0.0 2.5 2 0 0 2 2 2 2 APOBEC3 Nuc_sug_transp PF04142.15 KPI84732.1 - 2.1e-70 237.4 16.2 1.1e-62 212.1 7.6 2.4 2 1 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 KPI84732.1 - 1.7e-06 28.3 26.9 2.1e-05 24.7 3.4 3.9 4 1 0 4 4 4 3 EamA-like transporter family PUNUT PF16913.5 KPI84732.1 - 0.00011 21.5 1.2 0.00011 21.5 1.2 3.1 4 0 0 4 4 4 1 Purine nucleobase transmembrane transport TPT PF03151.16 KPI84732.1 - 0.091 12.1 7.8 0.032 13.6 0.5 2.8 3 0 0 3 3 3 0 Triose-phosphate Transporter family Pox_A_type_inc PF04508.12 KPI84735.1 - 1.6e-07 30.8 3.9 0.13 12.2 0.1 3.8 4 0 0 4 4 4 3 Viral A-type inclusion protein repeat PKcGMP_CC PF16808.5 KPI84735.1 - 0.01 15.6 9.7 0.099 12.5 0.2 4.1 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FAM199X PF15814.5 KPI84735.1 - 0.12 11.4 1.9 0.22 10.5 1.9 1.4 1 0 0 1 1 1 0 Protein family FAM199X HalX PF08663.10 KPI84735.1 - 0.15 12.4 0.4 0.15 12.4 0.4 3.0 2 1 1 3 3 3 0 HalX domain RsgA_GTPase PF03193.16 KPI84735.1 - 0.17 11.8 0.8 0.31 10.9 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase BBP1_C PF15272.6 KPI84735.1 - 0.9 9.3 5.5 3.2 7.5 1.9 2.6 2 1 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Mt_ATP-synt_D PF05873.12 KPI84735.1 - 5.8 6.7 6.8 12 5.8 0.2 2.5 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) HR1 PF02185.16 KPI84735.1 - 8.6 6.6 14.8 1.3 9.2 0.7 3.6 2 1 1 3 3 3 0 Hr1 repeat NPL PF17800.1 KPI84737.1 - 6.9e-11 42.7 0.0 1.1e-10 42.0 0.0 1.3 1 0 0 1 1 1 1 Nucleoplasmin-like domain ETF_QO PF05187.13 KPI84738.1 - 6.6e-44 148.3 0.2 1.2e-43 147.5 0.2 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 KPI84738.1 - 8.7e-11 42.0 0.3 1.1e-05 25.2 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KPI84738.1 - 6.2e-09 35.4 0.7 0.0002 20.6 1.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KPI84738.1 - 1.2e-06 28.6 0.2 8.1e-06 26.0 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KPI84738.1 - 6.3e-06 25.6 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KPI84738.1 - 2.4e-05 23.7 0.1 0.0012 18.2 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 KPI84738.1 - 0.00013 22.5 0.2 0.41 11.2 0.2 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI84738.1 - 0.00021 20.1 0.4 0.00035 19.4 0.4 1.3 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 KPI84738.1 - 0.00037 19.7 0.1 0.00054 19.1 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 KPI84738.1 - 0.00051 20.1 0.1 0.001 19.1 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 KPI84738.1 - 0.0038 16.5 0.1 0.0073 15.6 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 KPI84738.1 - 0.0072 15.2 0.8 0.041 12.7 0.2 2.0 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 KPI84738.1 - 0.0084 15.5 0.2 0.0084 15.5 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KPI84738.1 - 0.01 15.1 0.3 0.015 14.5 0.3 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KPI84738.1 - 0.018 14.1 0.1 0.039 13.0 0.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Sel1 PF08238.12 KPI84739.1 - 3e-21 75.4 31.2 5.5e-06 26.9 0.2 8.1 8 0 0 8 8 8 6 Sel1 repeat CLP1_P PF16575.5 KPI84740.1 - 3.6e-27 95.4 0.0 9.9e-27 93.9 0.0 1.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF2398 PF09661.10 KPI84740.1 - 0.00096 18.5 0.3 0.0029 16.9 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2398) AAA_16 PF13191.6 KPI84740.1 - 0.13 12.7 1.2 0.26 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 KPI84742.1 - 5.5e-56 188.6 0.0 6.4e-56 188.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI84742.1 - 2.2e-29 102.1 0.0 3.1e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI84742.1 - 1.8e-11 43.8 0.0 2.2e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI84742.1 - 0.00023 21.2 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI84742.1 - 0.0011 18.5 0.0 0.032 13.8 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KPI84742.1 - 0.0083 15.5 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SOAR PF16533.5 KPI84743.1 - 0.029 14.3 0.6 0.1 12.6 0.6 1.9 1 0 0 1 1 1 0 STIM1 Orai1-activating region SOGA PF11365.8 KPI84743.1 - 3.4 8.8 6.9 0.46 11.6 1.6 2.4 2 0 0 2 2 2 0 Protein SOGA PFL-like PF02901.15 KPI84744.1 - 0.14 10.7 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Pyruvate formate lyase-like SGS PF05002.15 KPI84745.1 - 7.9e-30 102.8 0.4 1.4e-29 102.0 0.4 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.16 KPI84745.1 - 5.6e-08 33.7 0.1 9.9e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 CS domain AAA PF00004.29 KPI84747.1 - 8.4e-27 94.2 0.0 2.3e-26 92.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI84747.1 - 6.6e-05 23.2 1.1 0.012 15.9 0.1 4.1 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KPI84747.1 - 0.0003 21.2 5.1 0.005 17.2 0.2 3.8 2 2 1 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 KPI84747.1 - 0.0021 18.6 0.0 0.0044 17.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 KPI84747.1 - 0.0035 17.9 0.0 0.021 15.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KPI84747.1 - 0.0039 16.9 0.2 0.047 13.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain TIP49 PF06068.13 KPI84747.1 - 0.0048 16.1 0.0 0.0081 15.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 KPI84747.1 - 0.0074 16.5 0.0 0.0074 16.5 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 KPI84747.1 - 0.013 15.0 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 KPI84747.1 - 0.013 15.4 0.1 0.069 13.1 0.1 2.3 1 1 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 KPI84747.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 KPI84747.1 - 0.09 13.3 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KPI84747.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 KPI84747.1 - 0.24 11.7 1.1 0.67 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KPI84747.1 - 0.76 9.3 4.4 1.6 8.3 0.7 3.1 2 1 0 2 2 2 0 AAA domain DUF4456 PF14644.6 KPI84748.1 - 1.6e-10 41.1 0.3 1.6e-10 41.1 0.3 4.4 5 1 0 5 5 5 1 Domain of unknown function (DUF4456) DUF4455 PF14643.6 KPI84748.1 - 0.00055 18.7 1.4 0.00055 18.7 1.4 5.0 5 0 0 5 5 5 2 Domain of unknown function (DUF4455) DUF3972 PF13118.6 KPI84748.1 - 0.075 13.5 0.6 22 5.5 0.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3972) FliL PF03748.14 KPI84748.1 - 0.4 11.3 2.0 9.4 6.9 0.2 3.0 2 0 0 2 2 2 0 Flagellar basal body-associated protein FliL Methyltransf_16 PF10294.9 KPI84750.1 - 4e-10 39.7 0.0 0.00044 20.0 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 KPI84750.1 - 0.00046 20.1 0.0 0.00076 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84750.1 - 0.012 16.3 0.0 0.23 12.2 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84750.1 - 0.026 15.2 0.0 0.28 11.9 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain 3HCDH_RFF PF18321.1 KPI84752.1 - 0.047 14.1 2.8 1.8 9.1 0.0 3.8 3 0 0 3 3 3 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain SPG48 PF14764.6 KPI84752.1 - 0.1 13.0 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 AP-5 complex subunit, vesicle trafficking Myotub-related PF06602.14 KPI84753.1 - 2.6e-87 293.0 0.0 7.6e-87 291.5 0.0 1.7 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 KPI84753.1 - 0.011 15.7 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family FYVE PF01363.21 KPI84753.1 - 0.36 11.0 12.0 1.1 9.4 12.0 1.8 1 0 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.16 KPI84753.1 - 0.77 10.0 9.3 2 8.7 9.3 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger DAP10 PF07213.11 KPI84755.1 - 1.7 8.7 3.4 7.5 6.6 0.0 2.6 2 0 0 2 2 2 0 DAP10 membrane protein ABC_tran PF00005.27 KPI84757.1 - 3.4e-50 170.1 0.0 2.3e-25 89.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 KPI84757.1 - 8.9e-42 143.4 24.9 1.1e-40 139.8 24.9 2.0 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 KPI84757.1 - 8.9e-20 71.7 0.0 3.6e-07 30.3 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI84757.1 - 3.4e-06 26.6 0.0 0.8 9.1 0.0 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 KPI84757.1 - 1.4e-05 25.0 0.0 0.85 9.3 0.0 4.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_23 PF13476.6 KPI84757.1 - 5.8e-05 23.7 2.4 0.12 12.9 0.1 2.5 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 KPI84757.1 - 0.00012 22.3 0.0 0.2 11.9 0.0 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 KPI84757.1 - 0.00025 21.0 0.0 0.066 13.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase SRP54 PF00448.22 KPI84757.1 - 0.0003 20.5 0.1 0.17 11.5 0.0 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_30 PF13604.6 KPI84757.1 - 0.001 18.9 0.0 0.57 9.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 KPI84757.1 - 0.001 18.4 0.0 5.6 6.2 0.0 3.5 3 0 0 3 3 3 1 Zeta toxin DUF4162 PF13732.6 KPI84757.1 - 0.0014 19.3 0.0 0.73 10.6 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) ABC2_membrane PF01061.24 KPI84757.1 - 0.0026 17.2 12.5 0.0026 17.2 12.5 2.1 2 0 0 2 2 2 1 ABC-2 type transporter AAA_29 PF13555.6 KPI84757.1 - 0.0047 16.7 1.4 0.77 9.5 0.0 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 KPI84757.1 - 0.034 14.5 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 KPI84757.1 - 0.045 14.2 0.1 1.8 9.0 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 KPI84757.1 - 0.054 13.8 0.2 6.9 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KPI84757.1 - 0.057 13.5 0.0 11 6.1 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF2684 PF10885.8 KPI84757.1 - 0.068 13.3 0.0 16 5.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) cobW PF02492.19 KPI84757.1 - 0.074 12.6 0.3 2.6 7.6 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 KPI84757.1 - 0.13 12.5 0.4 6.5 7.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KPI84757.1 - 0.14 12.4 0.1 2.8 8.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain ER_lumen_recept PF00810.18 KPI84757.1 - 0.53 11.1 9.2 0.19 12.5 6.2 1.8 2 0 0 2 2 1 0 ER lumen protein retaining receptor ABC2_membrane_2 PF12679.7 KPI84757.1 - 2.4 7.4 8.8 5.3 6.2 8.8 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein TatD_DNase PF01026.21 KPI84758.1 - 3.7e-49 167.4 0.0 5.4e-49 166.9 0.0 1.2 1 1 0 1 1 1 1 TatD related DNase ABC2_membrane_3 PF12698.7 KPI84759.1 - 1.8e-62 211.5 50.2 2.8e-41 141.8 19.1 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 KPI84759.1 - 6.8e-51 172.4 0.0 5e-26 91.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KPI84759.1 - 1.1e-17 64.8 0.2 1.7e-07 31.3 0.0 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI84759.1 - 1.6e-06 27.7 0.0 0.59 9.5 0.0 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KPI84759.1 - 7.5e-05 23.3 2.3 0.1 13.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KPI84759.1 - 0.0003 20.7 0.0 0.16 11.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase SRP54 PF00448.22 KPI84759.1 - 0.00048 19.8 0.1 0.46 10.1 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_15 PF13175.6 KPI84759.1 - 0.00064 19.5 0.0 2.1 8.0 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.6 KPI84759.1 - 0.00066 19.9 0.0 1.7 9.0 0.0 3.9 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 KPI84759.1 - 0.0012 18.6 0.0 0.2 11.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KPI84759.1 - 0.0039 16.9 0.0 1 9.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 KPI84759.1 - 0.011 16.0 0.8 11 6.2 0.1 3.6 3 1 0 3 3 3 0 AAA domain KdpD PF02702.17 KPI84759.1 - 0.013 15.0 0.0 0.075 12.5 0.0 2.2 2 0 0 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain MukB PF04310.12 KPI84759.1 - 0.016 15.0 0.1 3.3 7.5 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal Zeta_toxin PF06414.12 KPI84759.1 - 0.029 13.6 0.0 1.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 KPI84759.1 - 0.062 13.7 0.0 3.5 8.1 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) HEAT PF02985.22 KPI84761.1 - 1.2e-06 28.2 6.6 0.081 13.2 0.2 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 KPI84761.1 - 0.0012 19.2 7.5 0.032 14.6 0.6 3.8 2 2 1 3 3 3 2 HEAT repeats Proteasom_PSMB PF10508.9 KPI84761.1 - 0.0056 15.3 1.2 0.0095 14.5 1.2 1.4 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit HEAT_EZ PF13513.6 KPI84761.1 - 0.11 13.0 1.8 7.3 7.2 0.1 3.4 3 0 0 3 3 3 0 HEAT-like repeat Arm PF00514.23 KPI84761.1 - 0.31 11.2 0.0 0.31 11.2 0.0 3.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF2474 PF10617.9 KPI84762.1 - 3.2 7.7 10.1 14 5.6 2.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2474) PapD-like PF14874.6 KPI84763.1 - 4.3e-38 129.6 0.1 8.4e-38 128.6 0.1 1.5 1 0 0 1 1 1 1 Flagellar-associated PapD-like DUF1573 PF07610.11 KPI84763.1 - 0.061 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) Nodulin-like PF06813.13 KPI84764.1 - 2.1e-14 53.6 17.0 2.1e-14 53.6 17.0 2.5 2 1 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 KPI84764.1 - 4.4e-12 45.6 51.5 2.7e-06 26.6 16.8 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily Comm PF15957.5 KPI84764.1 - 0.017 15.5 0.0 0.051 13.9 0.0 1.8 1 0 0 1 1 1 0 Commissureless Wzz PF02706.15 KPI84764.1 - 0.4 11.0 4.5 0.6 10.4 0.5 2.9 2 0 0 2 2 2 0 Chain length determinant protein Ras PF00071.22 KPI84765.1 - 4e-47 159.8 0.0 4.7e-47 159.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI84765.1 - 2.6e-17 63.2 0.0 3.7e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI84765.1 - 0.00067 19.2 0.0 0.00088 18.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI84765.1 - 0.0084 16.2 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI84765.1 - 0.0087 15.6 0.1 0.027 14.0 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF3568 PF12092.8 KPI84765.1 - 0.031 14.4 2.6 0.098 12.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) RsgA_GTPase PF03193.16 KPI84765.1 - 0.036 14.0 0.0 4.9 7.0 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase baeRF_family3 PF18845.1 KPI84765.1 - 0.076 13.3 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 AAA_16 PF13191.6 KPI84765.1 - 0.13 12.7 0.1 13 6.1 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain ParA PF10609.9 KPI84765.1 - 0.15 11.5 0.1 0.3 10.5 0.1 1.5 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase BicD PF09730.9 KPI84766.1 - 0.00061 18.4 0.5 0.00078 18.0 0.5 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Cnn_1N PF07989.11 KPI84766.1 - 0.0017 18.5 1.1 0.0017 18.5 1.1 1.6 2 0 0 2 2 1 1 Centrosomin N-terminal motif 1 BLOC1_2 PF10046.9 KPI84766.1 - 0.0019 18.5 4.6 0.009 16.3 4.6 1.8 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1640 PF07798.11 KPI84766.1 - 0.0035 17.4 1.4 0.0052 16.9 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) DUF3450 PF11932.8 KPI84766.1 - 0.0048 16.2 3.4 0.0095 15.3 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) HALZ PF02183.18 KPI84766.1 - 0.0082 16.3 0.5 0.0082 16.3 0.5 2.1 2 0 0 2 2 2 1 Homeobox associated leucine zipper DivIC PF04977.15 KPI84766.1 - 0.0087 15.8 4.7 0.0087 15.8 4.7 1.8 1 1 1 2 2 2 1 Septum formation initiator Spc7 PF08317.11 KPI84766.1 - 0.0096 14.8 4.8 0.012 14.5 4.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein bZIP_1 PF00170.21 KPI84766.1 - 0.011 15.9 1.3 0.022 14.8 0.4 2.0 2 0 0 2 2 2 0 bZIP transcription factor Uso1_p115_C PF04871.13 KPI84766.1 - 0.011 16.1 5.7 0.016 15.6 5.7 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region JAKMIP_CC3 PF16034.5 KPI84766.1 - 0.014 15.4 1.3 0.02 14.8 1.3 1.2 1 0 0 1 1 1 0 JAKMIP CC3 domain AKNA PF12443.8 KPI84766.1 - 0.023 15.3 1.9 0.055 14.1 1.2 1.8 1 1 1 2 2 2 0 AT-hook-containing transcription factor FAM76 PF16046.5 KPI84766.1 - 0.028 13.8 0.3 0.034 13.5 0.3 1.1 1 0 0 1 1 1 0 FAM76 protein CorA PF01544.18 KPI84766.1 - 0.033 13.5 1.1 0.042 13.2 1.1 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein AAA_13 PF13166.6 KPI84766.1 - 0.038 12.6 2.6 0.048 12.3 2.6 1.0 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.9 KPI84766.1 - 0.043 12.9 1.4 0.054 12.6 1.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FPP PF05911.11 KPI84766.1 - 0.093 10.9 6.1 0.12 10.6 6.1 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Seadorna_VP6 PF07407.11 KPI84766.1 - 0.19 10.6 0.4 0.24 10.3 0.4 1.1 1 0 0 1 1 1 0 Seadornavirus VP6 protein YabA PF06156.13 KPI84766.1 - 0.19 12.4 1.8 0.3 11.7 1.8 1.3 1 0 0 1 1 1 0 Initiation control protein YabA CENP-H PF05837.12 KPI84766.1 - 0.58 10.6 5.5 1.2 9.6 5.5 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Csm1_N PF18504.1 KPI84766.1 - 0.85 10.0 8.1 0.14 12.5 3.4 1.9 2 0 0 2 2 2 0 Csm1 N-terminal domain ZapB PF06005.12 KPI84766.1 - 1.3 9.5 11.1 3.7 8.0 11.1 1.8 1 1 0 1 1 1 0 Cell division protein ZapB DUF5320 PF17253.2 KPI84766.1 - 6.3 7.9 4.9 9.3 7.4 1.4 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Ribosomal_L4 PF00573.22 KPI84767.1 - 2.7e-07 30.5 0.0 5.5e-07 29.5 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family STIMATE PF12400.8 KPI84768.1 - 6.6e-06 26.7 1.3 1.4e-05 25.6 1.3 1.6 1 1 0 1 1 1 1 STIMATE family SH3_9 PF14604.6 KPI84771.1 - 3.2e-11 42.9 0.1 5.9e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KPI84771.1 - 4.8e-10 39.0 0.0 9.1e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KPI84771.1 - 5.4e-10 38.7 0.0 9.3e-10 38.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain E2R135 PF11570.8 KPI84771.1 - 0.034 14.4 0.4 0.034 14.4 0.4 2.4 3 0 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 SAM_Exu PF18609.1 KPI84771.1 - 0.093 12.8 1.2 0.28 11.3 1.2 1.8 1 0 0 1 1 1 0 Exuperantia SAM-like domain Spc7 PF08317.11 KPI84771.1 - 0.6 8.9 30.0 0.82 8.5 3.3 3.1 2 1 1 3 3 3 0 Spc7 kinetochore protein Mod_r PF07200.13 KPI84771.1 - 5 7.2 29.1 0.35 11.0 6.6 3.1 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein ATP-synt PF00231.19 KPI84772.1 - 2.3e-47 162.0 0.7 2.6e-47 161.9 0.7 1.0 1 0 0 1 1 1 1 ATP synthase DKCLD PF08068.12 KPI84773.1 - 5.5e-30 103.2 0.1 9e-29 99.3 0.1 2.5 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 KPI84773.1 - 8.1e-22 78.2 2.0 2.5e-18 66.8 2.0 3.2 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KPI84773.1 - 1.6e-20 73.0 0.2 3.9e-20 71.8 0.2 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 KPI84773.1 - 4.4e-20 71.4 1.1 8.7e-20 70.5 1.1 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 KPI84773.1 - 0.022 15.0 0.0 0.088 13.1 0.0 2.0 2 0 0 2 2 2 0 UPF0113 PUA domain SET PF00856.28 KPI84774.1 - 2.6e-05 24.7 1.1 0.00064 20.1 1.1 2.3 1 1 0 1 1 1 1 SET domain Peptidase_C97 PF05903.14 KPI84774.1 - 0.052 13.4 0.1 0.088 12.6 0.1 1.3 1 0 0 1 1 1 0 PPPDE putative peptidase domain PHD PF00628.29 KPI84774.1 - 1.2 9.1 15.1 2.1 8.3 14.2 2.0 1 1 0 1 1 1 0 PHD-finger PAP_assoc PF03828.19 KPI84775.1 - 7.8e-05 22.8 0.6 0.00022 21.3 0.6 1.8 1 1 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KPI84775.1 - 0.15 12.3 0.5 0.52 10.6 0.0 2.1 2 1 0 2 2 2 0 Nucleotidyltransferase domain Ribosomal_L32e PF01655.18 KPI84776.1 - 1.1e-39 135.1 0.1 1.4e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 DUF4874 PF16173.5 KPI84777.1 - 0.16 11.7 0.3 0.22 11.2 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) Proteasome PF00227.26 KPI84778.1 - 2.8e-64 216.1 0.0 4e-64 215.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI84778.1 - 6.7e-09 35.3 0.6 3.6e-08 32.9 0.1 2.2 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature YadA_head PF05658.14 KPI84778.1 - 4.3 7.9 6.3 0.95 9.9 1.2 2.1 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin MCU PF04678.13 KPI84779.1 - 1.8e-28 99.8 0.0 3.5e-28 98.9 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial calcium uniporter Kinase-PolyVal PF18762.1 KPI84779.1 - 0.15 12.0 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins PUF PF00806.19 KPI84780.1 - 1.3e-49 163.2 5.1 4.4e-06 26.1 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 KPI84780.1 - 0.011 16.1 0.4 30 5.0 0.0 3.6 2 1 2 4 4 4 0 CPL (NUC119) domain DUF5410 PF17422.2 KPI84780.1 - 0.14 11.4 0.1 0.46 9.7 0.0 1.8 2 1 1 3 3 3 0 Family of unknown function (DUF5410) zf-MYND PF01753.18 KPI84781.1 - 1.8e-05 24.7 15.4 4.8e-05 23.4 15.4 1.8 1 0 0 1 1 1 1 MYND finger DUF3361 PF11841.8 KPI84782.1 - 0.092 12.7 0.0 0.33 10.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) 5_3_exonuc_N PF02739.16 KPI84783.1 - 1.9e-25 89.6 0.1 3.1e-25 88.9 0.1 1.3 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 KPI84783.1 - 2.7e-19 69.6 0.0 6.1e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Pkinase PF00069.25 KPI84784.1 - 1.8e-41 142.2 0.0 2.3e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84784.1 - 4.7e-10 39.2 0.0 1.5e-09 37.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KPI84784.1 - 0.038 13.9 0.1 0.065 13.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI84784.1 - 0.05 12.9 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like EF-hand_1 PF00036.32 KPI84786.1 - 1.3e-23 80.7 8.6 1.8e-06 27.1 0.2 4.5 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KPI84786.1 - 4.5e-22 78.3 2.9 4.7e-12 46.2 0.9 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KPI84786.1 - 8e-19 65.9 7.2 0.0003 20.5 0.3 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KPI84786.1 - 3.3e-17 61.1 11.8 2.2e-06 26.9 0.2 5.0 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KPI84786.1 - 2.1e-10 40.2 8.3 0.0014 18.4 1.0 4.4 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 KPI84786.1 - 2e-08 34.1 2.5 0.034 14.1 0.2 3.5 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KPI84786.1 - 3e-06 27.5 0.0 0.045 14.1 0.0 2.5 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KPI84786.1 - 0.0007 19.7 2.4 0.26 11.5 2.1 3.0 2 1 1 3 3 3 1 Dockerin type I domain DUF1425 PF07233.12 KPI84786.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1425) PPR_2 PF13041.6 KPI84787.1 - 6.5e-08 32.6 0.1 1.7e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 KPI84787.1 - 6.9e-05 22.8 0.0 0.00021 21.3 0.0 1.9 1 0 0 1 1 1 1 PPR repeat PPR_3 PF13812.6 KPI84787.1 - 7.6e-05 22.7 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_long PF17177.4 KPI84787.1 - 0.0023 17.4 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP Rad60-SLD_2 PF13881.6 KPI84788.1 - 6.9e-05 22.9 4.7 0.00078 19.5 4.7 2.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like SRP-alpha_N PF04086.13 KPI84788.1 - 0.024 14.6 0.3 0.024 14.6 0.3 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2407 PF10302.9 KPI84788.1 - 0.086 13.4 0.2 0.17 12.4 0.2 1.7 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain NTP_transf_3 PF12804.7 KPI84789.1 - 0.0059 17.0 0.5 0.007 16.7 0.5 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain zf-Sec23_Sec24 PF04810.15 KPI84789.1 - 0.25 11.4 2.1 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Rubredoxin PF00301.20 KPI84789.1 - 0.44 10.6 4.5 4.9 7.3 0.1 2.4 2 0 0 2 2 2 0 Rubredoxin F-box-like PF12937.7 KPI84790.1 - 3e-08 33.4 0.3 8.5e-08 32.0 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KPI84790.1 - 3e-06 27.0 0.6 7.9e-06 25.6 0.6 1.7 1 0 0 1 1 1 1 F-box domain MFS_1 PF07690.16 KPI84791.1 - 5.4e-06 25.6 45.7 4.9e-05 22.4 27.8 2.8 2 2 0 2 2 2 2 Major Facilitator Superfamily Bac_export_2 PF01312.19 KPI84791.1 - 1 8.5 5.4 0.36 10.0 0.3 2.3 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family Nodulin-like PF06813.13 KPI84791.1 - 3.1 7.2 29.2 5.1 6.5 24.9 3.0 2 1 0 2 2 2 0 Nodulin-like zf-MIZ PF02891.20 KPI84792.1 - 9.2e-18 63.7 5.9 1.6e-17 63.0 5.9 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PWWP PF00855.17 KPI84792.1 - 1e-05 25.9 0.1 2.2e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 PWWP domain zf-Nse PF11789.8 KPI84792.1 - 5.1e-05 23.0 3.6 0.00012 21.8 3.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Agenet PF05641.12 KPI84792.1 - 0.075 13.5 0.2 0.17 12.4 0.2 1.6 1 0 0 1 1 1 0 Agenet domain Pkinase PF00069.25 KPI84794.1 - 5.5e-24 84.9 0.0 7.1e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84794.1 - 4.8e-12 45.7 0.0 6e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI84794.1 - 1.7e-10 40.3 0.0 2.4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI84794.1 - 0.098 12.6 0.0 0.26 11.2 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Yippee-Mis18 PF03226.14 KPI84795.1 - 2.1e-10 40.8 0.1 2.6e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 KPI84795.1 - 0.0021 18.3 0.1 0.0028 17.9 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I zinc_ribbon_2 PF13240.6 KPI84795.1 - 0.18 11.6 4.1 8.6 6.2 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain TPR_16 PF13432.6 KPI84796.1 - 2.3e-07 31.3 6.9 7.5e-05 23.3 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI84796.1 - 2.8e-06 27.3 1.5 12 6.5 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84796.1 - 2.7e-05 24.6 3.8 0.0047 17.6 0.1 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KPI84796.1 - 7.7e-05 22.8 1.2 0.33 11.1 0.5 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI84796.1 - 0.00025 21.5 4.3 0.0065 17.0 0.6 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI84796.1 - 0.0017 18.1 2.7 6 6.9 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TTC5_OB PF16669.5 KPI84796.1 - 0.0027 17.4 0.3 0.014 15.1 0.3 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_2 PF07719.17 KPI84796.1 - 0.013 15.6 9.9 0.014 15.4 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI84796.1 - 0.033 14.4 1.8 0.068 13.4 0.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KPI84796.1 - 0.16 12.3 3.9 11 6.5 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat tRNA_int_endo PF01974.17 KPI84797.1 - 2.6e-05 24.2 0.0 3.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DNA_ligase_A_M PF01068.21 KPI84798.1 - 5.7e-55 186.1 0.0 9.2e-55 185.5 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KPI84798.1 - 7.6e-34 117.5 0.0 1.3e-33 116.8 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 KPI84798.1 - 2.9e-23 82.3 0.0 7e-23 81.1 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 KPI84798.1 - 1.9e-05 25.0 0.1 3.3e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 KPI84798.1 - 0.069 13.2 0.3 4.3 7.4 0.0 2.7 2 0 0 2 2 2 0 DNA ligase OB-like domain MKT1_C PF12246.8 KPI84799.1 - 5e-17 61.9 0.0 8e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 KPI84799.1 - 8.6e-08 32.4 0.0 2.2e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication Tcp11 PF05794.13 KPI84800.1 - 1.8e-26 93.3 7.4 3.5e-26 92.3 7.4 1.4 1 0 0 1 1 1 1 T-complex protein 11 Elong_Iki1 PF10483.9 KPI84800.1 - 0.015 14.8 0.1 0.058 12.9 0.0 2.0 2 0 0 2 2 2 0 Elongator subunit Iki1 RNA_pol_Rpb1_4 PF05000.17 KPI84800.1 - 0.027 14.4 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 4 BESS PF02944.20 KPI84800.1 - 0.13 12.1 0.1 0.59 10.0 0.0 2.3 2 0 0 2 2 2 0 BESS motif WD40 PF00400.32 KPI84801.1 - 3.4e-07 30.8 5.7 6 7.9 0.0 5.1 4 0 0 4 4 4 4 WD domain, G-beta repeat Dynein_heavy PF03028.15 KPI84801.1 - 1.1e-06 28.7 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain CAS_CSE1 PF03378.15 KPI84803.1 - 7.1e-81 272.0 0.0 1.1e-80 271.4 0.0 1.3 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 KPI84803.1 - 3e-52 177.7 0.0 4.1e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 KPI84803.1 - 2.7e-06 27.2 2.2 0.0002 21.2 0.1 3.7 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 KPI84803.1 - 0.037 14.1 0.2 0.56 10.3 0.0 3.2 2 2 0 2 2 2 0 Exportin 1-like protein PGK PF00162.19 KPI84804.1 - 1.7e-134 448.5 0.3 2.1e-134 448.3 0.3 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase PAS PF00989.25 KPI84804.1 - 6e-07 29.5 0.0 2.1e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KPI84804.1 - 5.2e-05 23.5 0.0 0.00018 21.7 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 KPI84804.1 - 0.00065 19.9 0.0 0.0023 18.2 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 KPI84804.1 - 0.001 19.1 0.0 0.003 17.5 0.0 1.9 1 0 0 1 1 1 1 PAS domain bPH_1 PF08000.11 KPI84804.1 - 0.018 15.2 0.3 0.033 14.3 0.3 1.4 1 0 0 1 1 1 0 Bacterial PH domain RRM_1 PF00076.22 KPI84806.1 - 1.3e-06 28.1 0.0 2.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4217 PF13959.6 KPI84809.1 - 0.0017 18.5 0.8 0.02 15.1 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) KinB_sensor PF16767.5 KPI84810.1 - 0.061 13.8 1.2 0.21 12.1 0.2 2.4 2 0 0 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB AT_hook PF02178.19 KPI84812.1 - 0.031 14.1 3.8 0.14 12.1 3.8 2.2 1 0 0 1 1 1 0 AT hook motif PQ-loop PF04193.14 KPI84815.1 - 6.4e-24 83.5 2.3 2.7e-12 46.2 0.1 2.4 2 0 0 2 2 2 2 PQ loop repeat Thioredoxin_2 PF13098.6 KPI84816.1 - 0.011 16.2 0.0 0.052 14.0 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain Pkinase PF00069.25 KPI84817.1 - 1.9e-44 152.0 0.0 9.4e-44 149.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84817.1 - 7.9e-18 64.7 0.0 1.8e-16 60.2 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KPI84817.1 - 0.19 11.6 2.7 0.93 9.4 0.0 3.1 3 1 1 4 4 4 0 Phosphotransferase enzyme family AAA_6 PF12774.7 KPI84818.1 - 1.1e-139 465.0 0.7 1.4e-138 461.3 0.1 2.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI84818.1 - 3.2e-105 352.5 2.2 3.2e-105 352.5 2.2 2.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI84818.1 - 7.7e-92 307.3 0.0 2e-91 305.9 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KPI84818.1 - 4.4e-84 282.3 0.3 4.1e-83 279.1 0.0 2.7 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KPI84818.1 - 3.5e-71 238.8 0.0 1.6e-70 236.7 0.0 2.3 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI84818.1 - 2.6e-56 190.0 3.6 6.5e-52 175.7 0.0 4.2 5 0 0 5 5 3 2 P-loop containing dynein motor region MT PF12777.7 KPI84818.1 - 4.1e-44 151.0 3.7 4.1e-44 151.0 3.7 1.8 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KPI84818.1 - 4.5e-40 136.5 0.0 3.3e-37 127.2 0.0 4.5 4 0 0 4 4 4 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 KPI84818.1 - 2.8e-28 98.8 0.0 1.1e-27 96.9 0.0 2.0 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KPI84818.1 - 3e-19 69.4 0.8 2.2e-05 24.5 0.0 5.9 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KPI84818.1 - 5.2e-17 61.9 0.0 2.4e-16 59.8 0.0 2.2 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KPI84818.1 - 7.7e-14 51.9 0.1 2e-12 47.3 0.1 3.0 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 KPI84818.1 - 3.5e-07 30.6 9.1 0.00055 20.2 0.1 5.9 6 0 0 6 6 5 1 AAA domain T2SSE PF00437.20 KPI84818.1 - 6.8e-05 22.0 5.0 0.01 14.9 0.5 2.9 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_16 PF13191.6 KPI84818.1 - 0.0013 19.1 16.9 0.056 13.8 0.0 6.6 6 0 0 6 6 4 1 AAA ATPase domain DUF815 PF05673.13 KPI84818.1 - 0.0022 17.2 0.0 0.077 12.1 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 KPI84818.1 - 0.0023 17.4 1.5 0.57 9.5 0.0 3.6 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI AIG1 PF04548.16 KPI84818.1 - 0.012 15.0 2.2 0.018 14.4 0.1 2.4 2 0 0 2 2 2 0 AIG1 family TniB PF05621.11 KPI84818.1 - 0.016 14.6 0.2 0.91 8.9 0.0 2.7 2 0 0 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 KPI84818.1 - 0.02 14.6 0.8 0.59 9.8 0.0 3.1 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA PF00004.29 KPI84818.1 - 0.021 15.3 5.9 2 8.8 0.0 4.4 5 0 0 5 5 3 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KPI84818.1 - 0.022 15.1 0.3 22 5.5 0.0 3.9 4 0 0 4 4 3 0 RNA helicase DUF916 PF06030.12 KPI84818.1 - 0.055 13.5 0.3 0.15 12.2 0.3 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) HTH_57 PF18679.1 KPI84818.1 - 0.14 12.5 4.8 15 6.0 0.3 4.6 4 0 0 4 4 4 0 ThcOx helix turn helix domain IIGP PF05049.13 KPI84818.1 - 0.15 11.1 0.0 0.35 9.9 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) LMBR1 PF04791.16 KPI84818.1 - 0.17 10.8 0.6 0.48 9.3 0.2 1.8 1 1 0 1 1 1 0 LMBR1-like membrane protein FtsK_SpoIIIE PF01580.18 KPI84818.1 - 0.18 11.2 2.0 0.93 8.8 0.0 3.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family Septin PF00735.18 KPI84818.1 - 0.18 11.1 1.0 4.5 6.5 0.2 2.4 2 0 0 2 2 2 0 Septin RsgA_GTPase PF03193.16 KPI84818.1 - 0.18 11.7 6.4 0.47 10.3 0.1 3.5 4 0 0 4 4 3 0 RsgA GTPase AAA_18 PF13238.6 KPI84818.1 - 1.2 9.7 4.5 4.7 7.8 0.0 4.3 5 0 0 5 5 4 0 AAA domain Tropomyosin PF00261.20 KPI84818.1 - 2.6 7.3 22.2 0.086 12.2 3.1 2.9 2 0 0 2 2 2 0 Tropomyosin DUF3450 PF11932.8 KPI84818.1 - 3.4 6.9 26.1 4.3 6.6 14.8 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Fzo_mitofusin PF04799.13 KPI84818.1 - 6.7 6.2 14.1 0.28 10.7 0.8 3.5 2 1 0 2 2 2 0 fzo-like conserved region V_ATPase_I PF01496.19 KPI84818.1 - 9.7 4.0 10.4 39 1.9 10.7 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family COQ9 PF08511.11 KPI84819.1 - 0.021 14.6 0.0 0.76 9.6 0.0 2.5 2 0 0 2 2 2 0 COQ9 PHM7_cyt PF14703.6 KPI84819.1 - 0.16 12.2 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter SET PF00856.28 KPI84820.1 - 1.5e-12 48.2 2.3 9.1e-12 45.7 2.3 2.2 1 1 0 1 1 1 1 SET domain MMgT PF10270.9 KPI84820.1 - 0.094 13.1 0.0 0.25 11.7 0.0 1.7 2 0 0 2 2 2 0 Membrane magnesium transporter MARVEL PF01284.23 KPI84821.1 - 7.6 6.6 11.6 3.1 7.8 6.7 2.2 1 1 1 2 2 2 0 Membrane-associating domain DUF202 PF02656.15 KPI84822.1 - 2.5e-16 59.8 0.7 2.1e-15 56.9 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4199 PF13858.6 KPI84822.1 - 0.017 15.5 0.8 0.023 15.1 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) SLATT_5 PF18160.1 KPI84822.1 - 4.3 6.6 5.3 0.78 9.0 0.4 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Sulfotransfer_3 PF13469.6 KPI84823.1 - 1.7e-06 28.6 0.0 3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family Ubie_methyltran PF01209.18 KPI84826.1 - 1.5e-103 345.2 0.0 1.7e-103 345.0 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 KPI84826.1 - 4.2e-16 59.4 0.0 4e-15 56.3 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI84826.1 - 1.9e-15 57.3 0.0 4e-15 56.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI84826.1 - 5.3e-10 39.3 0.0 8.1e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84826.1 - 4.2e-07 30.6 0.0 6.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KPI84826.1 - 0.0002 21.3 0.0 0.089 12.6 0.0 2.6 3 0 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_23 PF13489.6 KPI84826.1 - 0.00026 20.9 0.0 0.00041 20.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Pkinase PF00069.25 KPI84827.1 - 5.2e-57 193.2 0.0 8.3e-57 192.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84827.1 - 5.2e-36 124.3 0.0 1e-35 123.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI84827.1 - 1.8e-11 43.9 0.0 3.1e-08 33.3 0.0 2.3 2 0 0 2 2 2 2 Kinase-like C1_2 PF03107.16 KPI84827.1 - 0.00073 19.8 4.1 0.00073 19.8 4.1 2.3 2 0 0 2 2 2 1 C1 domain APH PF01636.23 KPI84827.1 - 0.00082 19.4 0.7 0.11 12.3 0.0 3.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KPI84827.1 - 0.026 13.6 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 KPI84827.1 - 0.026 13.9 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2_jaz PF12171.8 KPI84827.1 - 0.027 14.8 0.6 0.14 12.5 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Haspin_kinase PF12330.8 KPI84827.1 - 0.035 13.0 1.0 0.097 11.6 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain FYVE_2 PF02318.16 KPI84827.1 - 0.2 11.9 5.1 0.54 10.5 5.1 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger zf-piccolo PF05715.13 KPI84827.1 - 0.23 11.6 4.9 0.47 10.6 4.9 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger zf_C2H2_ZHX PF18387.1 KPI84827.1 - 2.9 7.6 6.0 0.7 9.6 0.0 2.8 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF4156 PF13698.6 KPI84828.1 - 9.4 6.6 10.7 3.6 8.0 0.5 4.1 3 2 2 5 5 5 0 Domain of unknown function (DUF4156) GST_C_2 PF13410.6 KPI84830.1 - 2.3e-09 37.1 0.1 7.8e-09 35.4 0.1 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KPI84830.1 - 0.00083 19.5 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KPI84830.1 - 0.1 12.8 0.0 0.45 10.8 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF4142 PF13628.6 KPI84833.1 - 0.068 13.4 6.1 0.74 10.0 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4142) Cnl2_NKP2 PF09447.10 KPI84833.1 - 0.35 11.1 5.6 0.54 10.4 0.6 2.9 3 0 0 3 3 3 0 Cnl2/NKP2 family protein HEAT_2 PF13646.6 KPI84834.1 - 0.00057 20.2 10.5 0.064 13.6 1.1 4.5 4 1 1 5 5 5 1 HEAT repeats Cnd1 PF12717.7 KPI84834.1 - 0.012 15.7 0.1 0.058 13.4 0.0 2.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KPI84834.1 - 0.034 14.4 0.1 0.034 14.4 0.1 6.2 6 1 1 7 7 7 0 HEAT repeat HEAT_EZ PF13513.6 KPI84834.1 - 0.091 13.3 0.1 0.091 13.3 0.1 6.5 7 1 0 7 7 7 0 HEAT-like repeat Ax_dynein_light PF10211.9 KPI84834.1 - 0.11 12.5 0.1 0.28 11.1 0.1 1.7 1 0 0 1 1 1 0 Axonemal dynein light chain Cohesin_HEAT PF12765.7 KPI84834.1 - 0.21 11.9 3.2 1.8 8.9 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DivIC PF04977.15 KPI84834.1 - 0.3 10.9 1.3 0.65 9.8 1.3 1.4 1 0 0 1 1 1 0 Septum formation initiator Exo_endo_phos PF03372.23 KPI84835.1 - 1e-05 25.2 0.0 0.0003 20.4 0.0 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KPI84835.1 - 0.027 14.3 0.0 0.4 10.5 0.0 2.7 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Adaptin_N PF01602.20 KPI84836.1 - 8.4e-82 275.4 0.0 1.1e-81 275.0 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KPI84836.1 - 5.9e-16 58.9 0.1 1.7e-15 57.4 0.1 1.8 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KPI84836.1 - 2.7e-06 27.7 6.2 2.6e-05 24.5 1.9 3.8 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.22 KPI84836.1 - 3.3e-05 23.8 3.5 1.5 9.3 0.0 4.4 3 0 0 3 3 3 3 HEAT repeat HEAT_EZ PF13513.6 KPI84836.1 - 0.019 15.5 4.6 0.33 11.5 0.2 3.9 3 0 0 3 3 3 0 HEAT-like repeat Bacillus_HBL PF05791.11 KPI84837.1 - 0.011 15.5 1.4 0.35 10.7 0.3 3.3 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Med12 PF09497.10 KPI84837.1 - 0.076 13.3 1.1 1.8 8.9 0.1 2.8 2 0 0 2 2 2 0 Transcription mediator complex subunit Med12 GPW_gp25 PF04965.14 KPI84837.1 - 0.14 12.0 1.0 0.46 10.3 0.1 2.2 2 0 0 2 2 2 0 Gene 25-like lysozyme CCDC-167 PF15188.6 KPI84837.1 - 3.3 8.1 5.8 1 9.8 0.6 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF724 PF05266.14 KPI84837.1 - 7.5 6.3 9.5 14 5.4 1.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF724) DraK_HK_N PF18092.1 KPI84838.1 - 0.14 12.6 2.5 0.62 10.5 2.5 2.1 1 1 0 1 1 1 0 DraK Histidine Kinase N-terminal domain BAR PF03114.18 KPI84839.1 - 0.003 17.2 1.0 0.0056 16.3 1.0 1.4 1 1 0 1 1 1 1 BAR domain MORN PF02493.20 KPI84840.1 - 5.3e-95 306.0 106.3 3e-10 39.4 2.5 15.2 15 0 0 15 15 15 15 MORN repeat Peptidase_S55 PF05580.12 KPI84840.1 - 0.033 14.1 13.6 1.4 8.9 0.2 5.4 3 1 2 5 5 5 0 SpoIVB peptidase S55 XPC-binding PF09280.11 KPI84841.1 - 6.4e-14 51.4 2.0 7.4e-14 51.2 0.1 2.2 3 0 0 3 3 3 1 XPC-binding domain ubiquitin PF00240.23 KPI84841.1 - 1.4e-13 50.4 0.0 2.4e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 KPI84841.1 - 2.5e-12 46.5 4.4 1.1e-07 31.6 0.4 2.6 2 0 0 2 2 2 2 UBA/TS-N domain Rad60-SLD PF11976.8 KPI84841.1 - 1.1e-06 28.4 0.0 2.6e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 KPI84841.1 - 0.0051 16.9 0.0 0.015 15.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 KPI84841.1 - 0.0079 16.9 0.0 0.079 13.7 0.0 2.4 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD MCM_N PF14551.6 KPI84841.1 - 0.051 14.2 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 MCM N-terminal domain DUF2407 PF10302.9 KPI84841.1 - 0.08 13.5 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Metallophos PF00149.28 KPI84843.1 - 1.2e-09 38.9 0.0 2e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ank_4 PF13637.6 KPI84845.1 - 4.1e-33 113.3 9.4 5e-07 30.1 0.0 6.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI84845.1 - 7e-31 106.7 3.5 2.1e-11 44.2 0.8 4.1 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI84845.1 - 1e-23 80.8 2.1 0.00093 19.5 0.0 7.8 8 0 0 8 8 8 6 Ankyrin repeat Ank PF00023.30 KPI84845.1 - 1.3e-23 82.3 6.5 6.3e-05 23.2 0.0 7.3 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 KPI84845.1 - 1e-20 73.5 11.3 7.7e-06 26.1 0.1 6.7 1 1 5 7 7 7 6 Ankyrin repeats (many copies) FlgN PF05130.12 KPI84845.1 - 0.1 13.1 2.7 9.1 6.8 0.0 3.3 3 1 0 3 3 3 0 FlgN protein HA2 PF04408.23 KPI84846.1 - 4.5e-11 43.0 0.0 4.5e-11 43.0 0.0 3.1 2 1 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI84846.1 - 2.1e-10 40.9 0.0 9.1e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI84846.1 - 2.7e-08 33.8 0.0 1.4e-07 31.4 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI84846.1 - 5.7e-06 26.6 1.2 1.9e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain OB_NTP_bind PF07717.16 KPI84846.1 - 6.9e-06 26.3 0.0 1.5e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.6 KPI84846.1 - 0.00025 21.4 0.0 0.001 19.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KPI84846.1 - 0.0038 17.3 1.5 0.03 14.3 0.0 3.0 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit ATPase PF06745.13 KPI84846.1 - 0.15 11.4 0.1 0.15 11.4 0.1 2.6 3 0 0 3 3 3 0 KaiC FtsK_SpoIIIE PF01580.18 KPI84846.1 - 0.16 11.3 0.0 0.16 11.3 0.0 2.6 2 1 1 3 3 3 0 FtsK/SpoIIIE family AAA_16 PF13191.6 KPI84846.1 - 0.3 11.4 2.1 1.3 9.4 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 KPI84846.1 - 0.41 11.1 0.0 0.41 11.1 0.0 3.2 2 1 1 3 3 2 0 AAA domain tRNA-synt_1c PF00749.21 KPI84847.1 - 6.3e-107 357.1 0.3 8.3e-107 356.7 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KPI84847.1 - 1.5e-35 122.6 0.1 2.9e-35 121.7 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 KPI84847.1 - 0.07 12.5 0.0 0.24 10.7 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain FKBP_C PF00254.28 KPI84851.1 - 0.062 13.6 0.1 0.49 10.7 0.0 2.4 3 0 0 3 3 3 0 FKBP-type peptidyl-prolyl cis-trans isomerase Ecotin PF03974.13 KPI84853.1 - 2.6e-24 85.6 0.0 3e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 Ecotin Totivirus_coat PF05518.11 KPI84853.1 - 0.14 10.1 0.0 0.19 9.7 0.0 1.1 1 0 0 1 1 1 0 Totivirus coat protein zinc-ribbon_6 PF10005.9 KPI84854.1 - 0.16 12.7 0.8 0.36 11.5 0.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 KPI84854.1 - 0.17 11.4 0.8 1.5 8.4 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain SR1P PF13790.6 KPI84854.1 - 0.21 11.8 0.1 4.5 7.5 0.0 2.2 2 0 0 2 2 2 0 SR1 protein zf-NADH-PPase PF09297.11 KPI84854.1 - 0.31 10.7 2.2 1.5 8.6 0.5 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain TF_Zn_Ribbon PF08271.12 KPI84854.1 - 1.3 8.6 3.0 6.2 6.4 0.0 2.5 3 0 0 3 3 3 0 TFIIB zinc-binding DZR PF12773.7 KPI84854.1 - 2.4 8.2 5.1 8.3 6.5 5.1 1.9 1 1 0 1 1 1 0 Double zinc ribbon Abhydrolase_3 PF07859.13 KPI84855.1 - 3e-12 46.8 0.1 6.9e-12 45.7 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 KPI84855.1 - 7e-09 35.1 0.1 1.7e-08 33.8 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 KPI84855.1 - 3.7e-05 24.4 0.1 8.5e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KPI84855.1 - 9.1e-05 22.0 0.2 0.063 12.7 0.1 2.8 2 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KPI84855.1 - 0.056 13.1 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Herpes_DNAp_acc PF04929.12 KPI84855.1 - 0.41 9.6 4.9 0.62 9.0 4.9 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Abhydrolase_3 PF07859.13 KPI84856.1 - 1.6e-11 44.5 0.0 2.8e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 KPI84856.1 - 5.4e-09 35.5 0.0 1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 KPI84856.1 - 0.00019 21.0 0.1 0.082 12.4 0.1 2.8 2 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KPI84856.1 - 0.052 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold SPX PF03105.19 KPI84857.1 - 3.9 7.3 21.6 0.095 12.6 6.0 2.2 1 1 0 2 2 2 0 SPX domain PseudoU_synth_2 PF00849.22 KPI84859.1 - 8.1e-18 65.0 1.1 7.4e-07 29.4 0.3 3.4 3 1 0 3 3 3 3 RNA pseudouridylate synthase Ribosomal_60s PF00428.19 KPI84860.1 - 9.2e-21 74.2 10.9 1.1e-20 74.1 10.9 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein 3HBOH PF10605.9 KPI84860.1 - 0.021 13.1 4.0 0.023 13.0 4.0 1.0 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) EGF_3 PF12947.7 KPI84860.1 - 0.073 13.3 0.2 0.13 12.5 0.2 1.4 1 0 0 1 1 1 0 EGF domain Glyco_hydro_14 PF01373.17 KPI84860.1 - 0.12 11.3 0.0 0.13 11.1 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 Asparaginase PF00710.20 KPI84861.1 - 2.6e-56 190.2 0.0 4.2e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 KPI84861.1 - 2.1e-22 79.5 0.0 3.5e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Zf_RING PF16744.5 KPI84861.1 - 0.16 12.1 0.1 0.41 10.8 0.1 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger PPR_2 PF13041.6 KPI84863.1 - 0.0022 18.1 0.0 0.022 14.9 0.0 2.3 2 0 0 2 2 2 1 PPR repeat family DUF2058 PF09831.9 KPI84866.1 - 1.1 9.4 10.9 0.14 12.3 5.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) FtsJ PF01728.19 KPI84868.1 - 3.2e-05 24.1 0.0 7.2e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Pet191_N PF10203.9 KPI84869.1 - 0.0082 16.4 5.0 0.21 11.9 0.7 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 KPI84869.1 - 0.44 10.6 8.6 0.14 12.2 1.2 2.6 1 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 KPI84869.1 - 2.2 8.5 9.7 0.12 12.5 3.4 2.2 3 0 0 3 3 3 0 CHCH domain Cmc1 PF08583.10 KPI84869.1 - 4.9 7.2 9.2 0.82 9.7 2.2 2.5 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Limkain-b1 PF11608.8 KPI84870.1 - 0.0028 17.7 0.0 0.0067 16.5 0.0 1.6 1 0 0 1 1 1 1 Limkain b1 Pkinase PF00069.25 KPI84871.1 - 7.4e-07 28.8 0.0 2e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain SUIM_assoc PF16619.5 KPI84871.1 - 0.41 10.7 12.7 0.16 12.1 3.1 4.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 KPI84872.1 - 1.1e-30 106.9 0.0 9.4e-15 54.7 0.0 3.5 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI84872.1 - 5.7e-05 22.5 0.0 0.00074 18.9 0.0 2.7 3 0 0 3 3 3 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KPI84872.1 - 0.015 14.3 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Aa_trans PF01490.18 KPI84873.1 - 1.1e-50 172.5 38.7 1.4e-50 172.2 38.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI84873.1 - 3.4e-07 29.7 27.3 4.6e-07 29.2 26.6 1.7 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.6 KPI84873.1 - 1.9 7.2 44.8 82 1.8 44.6 2.3 1 1 0 1 1 1 0 Amino acid permease KIAA1430 PF13879.6 KPI84874.1 - 2.2e-17 63.7 6.7 3.5e-17 63.0 6.7 1.3 1 0 0 1 1 1 1 KIAA1430 homologue Stn1 PF10451.9 KPI84874.1 - 0.042 12.8 1.2 0.056 12.4 1.2 1.1 1 0 0 1 1 1 0 Telomere regulation protein Stn1 p450 PF00067.22 KPI84875.1 - 1.5e-56 192.1 0.0 2.2e-56 191.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SH3BGR PF04908.15 KPI84876.1 - 0.1 12.7 0.2 0.55 10.4 0.0 1.9 1 1 0 2 2 2 0 SH3-binding, glutamic acid-rich protein LRR_8 PF13855.6 KPI84877.1 - 0.00022 20.9 2.5 0.036 13.8 0.1 3.4 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 KPI84877.1 - 0.0071 16.3 0.9 50 4.3 0.0 4.5 4 0 0 4 4 4 1 Leucine Rich repeat UPF0054 PF02130.17 KPI84878.1 - 2.7e-23 82.2 0.0 3.8e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 RtcB PF01139.17 KPI84879.1 - 0.063 12.5 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB zf-UBP PF02148.19 KPI84880.1 - 3e-15 56.3 9.1 3e-15 56.3 9.1 2.5 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein TMF_TATA_bd PF12325.8 KPI84880.1 - 0.022 15.0 1.3 0.048 13.9 1.3 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 KPI84880.1 - 0.077 13.1 0.5 0.19 11.8 0.5 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus COG2 PF06148.11 KPI84880.1 - 0.09 12.9 1.1 0.38 10.9 0.4 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4379 PF14311.6 KPI84881.1 - 2e-17 63.3 0.9 3.3e-17 62.6 0.9 1.4 1 0 0 1 1 1 1 Probable Zinc-ribbon domain HypA PF01155.19 KPI84881.1 - 0.049 13.6 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Thiolase_N PF00108.23 KPI84882.1 - 1.8e-64 217.7 0.7 2.6e-63 213.8 0.6 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KPI84882.1 - 9.2e-34 115.7 0.0 2e-33 114.7 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KPI84882.1 - 0.00087 18.9 4.7 0.0026 17.4 3.8 2.3 3 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain DRMBL PF07522.14 KPI84883.1 - 1.3e-14 54.3 0.0 2.6e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 KPI84883.1 - 0.063 12.8 0.0 0.18 11.3 0.0 1.9 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KPI84883.1 - 0.1 12.6 0.0 1.7 8.6 0.0 2.6 3 0 0 3 3 3 0 Metallo-beta-lactamase superfamily HA2 PF04408.23 KPI84885.1 - 2.2e-16 60.0 0.0 7e-16 58.5 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI84885.1 - 4.5e-11 43.1 0.0 2.1e-10 40.9 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain dsrm PF00035.26 KPI84885.1 - 8.2e-09 36.1 0.0 0.16 12.7 0.0 5.1 5 0 0 5 5 5 2 Double-stranded RNA binding motif DEAD PF00270.29 KPI84885.1 - 6.7e-07 29.2 0.1 1.4e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI84885.1 - 0.0077 16.5 0.0 0.023 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KPI84885.1 - 0.0084 15.2 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein OB_NTP_bind PF07717.16 KPI84885.1 - 0.022 15.1 0.0 0.058 13.8 0.0 1.7 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold NACHT PF05729.12 KPI84885.1 - 0.037 13.9 0.1 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 KPI84885.1 - 0.043 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KPI84885.1 - 0.094 12.1 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.6 KPI84885.1 - 0.098 12.7 0.1 3.4 7.7 0.1 2.7 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.15 KPI84885.1 - 0.1 12.5 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain PhoLip_ATPase_C PF16212.5 KPI84886.1 - 1.4e-36 126.5 23.3 1.4e-36 126.5 23.3 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 KPI84886.1 - 8.7e-14 51.4 0.9 3.9e-13 49.3 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KPI84886.1 - 3.7e-11 43.7 0.1 0.00033 21.0 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 KPI84886.1 - 5.1e-11 42.1 4.7 5.1e-11 42.1 4.7 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KPI84886.1 - 1e-07 31.9 0.0 4.3e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KPI84886.1 - 0.013 15.3 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ku PF02735.16 KPI84886.1 - 0.078 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Ku70/Ku80 beta-barrel domain Arteri_Gl PF00951.18 KPI84886.1 - 5.2 6.9 8.9 0.12 12.2 0.7 2.4 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein GCV_H PF01597.19 KPI84887.1 - 8.4e-05 22.4 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage H-protein DUF1344 PF07076.11 KPI84887.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) DUF4520 PF15016.6 KPI84887.1 - 0.12 12.5 0.1 0.25 11.4 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4520) Epimerase PF01370.21 KPI84889.1 - 1.2e-15 57.7 0.0 1.9e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KPI84889.1 - 2.8e-07 30.6 0.0 6e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KPI84889.1 - 4.8e-07 29.5 0.0 1.9e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 KPI84889.1 - 2.8e-06 27.1 0.0 0.0006 19.4 0.0 2.3 2 0 0 2 2 2 2 NmrA-like family 3Beta_HSD PF01073.19 KPI84889.1 - 9.5e-06 24.8 0.1 2.7e-05 23.3 0.1 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family ETF_alpha PF00766.19 KPI84890.1 - 6.9e-36 122.2 0.4 6.9e-36 122.2 0.4 2.2 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 KPI84890.1 - 3.4e-32 111.8 9.7 5.7e-32 111.1 9.7 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Amastin PF07344.11 KPI84891.1 - 1.3e-30 106.3 21.6 4e-18 65.7 7.8 2.2 2 0 0 2 2 2 2 Amastin surface glycoprotein GSG-1 PF07803.11 KPI84891.1 - 0.43 10.5 2.9 4.1 7.4 0.0 3.3 3 0 0 3 3 3 0 GSG1-like protein Amastin PF07344.11 KPI84892.1 - 3.6e-06 26.9 16.2 4.8e-06 26.5 15.7 1.5 1 1 0 1 1 1 1 Amastin surface glycoprotein PMP22_Claudin PF00822.20 KPI84892.1 - 0.12 12.2 13.1 0.11 12.4 11.3 1.9 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family MARVEL PF01284.23 KPI84892.1 - 0.54 10.3 15.1 2.1 8.3 15.1 2.0 1 1 0 1 1 1 0 Membrane-associating domain WD40 PF00400.32 KPI84893.1 - 2.4e-36 123.1 27.9 0.0001 23.0 0.0 10.5 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI84893.1 - 4e-15 55.9 0.2 0.0095 16.2 0.0 6.4 4 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KPI84893.1 - 0.013 14.9 0.9 7.1 5.9 0.1 3.6 2 1 0 3 3 3 0 WD40-like domain Gmad1 PF10647.9 KPI84893.1 - 0.023 14.4 1.7 7.6 6.2 0.1 3.8 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain PQQ_3 PF13570.6 KPI84893.1 - 0.087 13.3 13.8 33 5.1 1.5 6.8 6 1 1 7 7 7 0 PQQ-like domain WD40_3 PF15911.5 KPI84893.1 - 0.21 11.6 1.3 2.2 8.4 0.0 3.2 4 0 0 4 4 4 0 WD domain, G-beta repeat ubiquitin PF00240.23 KPI84894.1 - 1.9e-05 24.3 0.1 4.6e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family SKI PF01202.22 KPI84895.1 - 8e-09 35.8 0.0 1.1e-08 35.4 0.0 1.3 1 1 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 KPI84895.1 - 2.1e-06 28.3 0.0 6.4e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI84895.1 - 1.3e-05 25.4 0.0 2.2e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI84895.1 - 0.00023 21.4 0.0 0.00048 20.4 0.0 1.7 2 1 0 2 2 1 1 AAA domain AAA PF00004.29 KPI84895.1 - 0.00029 21.2 0.0 0.00052 20.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 KPI84895.1 - 0.0011 18.7 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase AAA_16 PF13191.6 KPI84895.1 - 0.0026 18.2 0.1 0.0037 17.7 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KPI84895.1 - 0.0095 15.8 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_5 PF07728.14 KPI84895.1 - 0.011 15.7 0.0 0.061 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI84895.1 - 0.013 15.2 0.0 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Cuticle_1 PF08140.11 KPI84895.1 - 0.013 15.5 0.0 5.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Crustacean cuticle protein repeat ABC_tran PF00005.27 KPI84895.1 - 0.015 15.8 0.0 0.019 15.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 KPI84895.1 - 0.024 14.9 0.0 0.045 14.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KPI84895.1 - 0.03 14.7 0.0 0.056 13.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PRK PF00485.18 KPI84895.1 - 0.045 13.5 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 KPI84895.1 - 0.052 13.5 0.0 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_17 PF13207.6 KPI84895.1 - 0.068 13.6 0.0 0.1 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KPI84895.1 - 0.13 12.0 0.1 0.4 10.4 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_24 PF13479.6 KPI84895.1 - 0.13 11.9 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATP-grasp_4 PF13535.6 KPI84896.1 - 9e-11 41.6 0.1 8.7e-08 31.9 0.1 2.8 3 0 0 3 3 3 2 ATP-grasp domain ATP-grasp_3 PF02655.14 KPI84896.1 - 2.4e-07 31.0 0.1 5.8e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_D2 PF02786.17 KPI84896.1 - 1.1e-05 25.0 0.2 0.014 14.9 0.1 2.6 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.6 KPI84896.1 - 0.0052 16.5 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon HMG_box_2 PF09011.10 KPI84897.1 - 0.027 15.0 0.0 0.082 13.5 0.0 1.8 1 0 0 1 1 1 0 HMG-box domain EF-hand_8 PF13833.6 KPI84903.1 - 0.001 18.9 1.1 0.034 14.0 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain pair Pro_isomerase PF00160.21 KPI84904.1 - 8.9e-40 136.5 0.0 1e-39 136.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ArfGap PF01412.18 KPI84906.1 - 9.5e-23 80.5 0.0 1.4e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf IRF-2BP1_2 PF11261.8 KPI84906.1 - 0.11 12.1 0.9 0.21 11.2 0.9 1.3 1 0 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger TBCC PF07986.12 KPI84907.1 - 4.7e-28 97.3 0.9 8.9e-28 96.4 0.9 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 KPI84907.1 - 6.9e-07 29.7 6.9 1.2e-06 29.0 6.9 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain TAN PF11640.8 KPI84907.1 - 0.0031 17.7 1.7 0.0054 16.9 1.7 1.3 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair ATF7IP_BD PF16788.5 KPI84907.1 - 0.018 15.2 0.3 0.023 14.8 0.3 1.1 1 0 0 1 1 1 0 ATF-interacting protein binding domain Cytochrom_B562 PF07361.11 KPI84907.1 - 0.08 13.6 2.2 1.1 9.9 2.0 2.2 1 1 1 2 2 2 0 Cytochrome b562 DUF3037 PF11236.8 KPI84907.1 - 0.11 12.9 3.3 0.19 12.1 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) DUF4472 PF14739.6 KPI84907.1 - 0.11 13.2 5.8 0.18 12.6 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) Endotoxin_N PF03945.14 KPI84907.1 - 0.2 11.3 0.1 0.31 10.7 0.1 1.2 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain DUF2514 PF10721.9 KPI84907.1 - 4.3 7.4 9.4 2.4 8.1 6.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2514) cobW PF02492.19 KPI84908.1 - 1.8e-47 161.2 0.4 2.5e-47 160.7 0.4 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KPI84908.1 - 0.0012 18.8 0.4 0.43 10.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 KPI84908.1 - 0.0027 17.5 0.2 0.0051 16.6 0.2 1.4 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 KPI84908.1 - 0.027 14.2 0.2 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.6 KPI84908.1 - 0.028 15.0 0.1 0.41 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KPI84908.1 - 0.04 14.2 0.0 0.094 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KPI84908.1 - 0.041 13.8 0.1 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 KPI84908.1 - 0.049 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CobW_C PF07683.14 KPI84908.1 - 0.05 13.5 0.0 0.098 12.6 0.0 1.5 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.14 KPI84908.1 - 0.051 13.5 0.1 0.32 10.9 0.1 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 KPI84908.1 - 0.052 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KPI84908.1 - 0.072 12.1 0.4 9.1 5.2 0.1 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 KPI84908.1 - 0.12 12.1 0.0 0.29 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain zf-C2H2_2 PF12756.7 KPI84908.1 - 0.12 12.7 0.8 0.32 11.4 0.1 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Guanylate_cyc PF00211.20 KPI84909.1 - 4.2e-39 134.0 0.0 8e-39 133.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF1935 PF09149.10 KPI84909.1 - 1.5e-25 89.5 0.0 4e-25 88.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) zf-CCHC PF00098.23 KPI84911.1 - 3.7e-20 71.0 85.6 9e-05 22.4 1.8 10.5 10 0 0 10 10 10 8 Zinc knuckle zf-CCHC_2 PF13696.6 KPI84911.1 - 1.9e-06 27.6 16.9 3.6e-05 23.5 3.0 9.8 8 1 1 9 9 9 4 Zinc knuckle NYN PF01936.18 KPI84911.1 - 0.0027 18.2 0.0 0.0079 16.7 0.0 1.8 1 1 0 1 1 1 1 NYN domain zf-CCHC_4 PF14392.6 KPI84911.1 - 4.7 7.0 79.4 0.089 12.5 3.9 10.0 7 3 3 10 10 10 0 Zinc knuckle Topoisom_bac PF01131.20 KPI84912.1 - 2.6e-104 349.5 0.0 3.4e-104 349.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KPI84912.1 - 2.9e-17 62.8 0.0 9e-17 61.2 0.0 1.9 2 0 0 2 2 2 1 Toprim domain zf-GRF PF06839.12 KPI84912.1 - 1.7e-08 34.4 1.8 1.7e-08 34.4 1.8 2.6 2 0 0 2 2 2 1 GRF zinc finger zf-C4_Topoisom PF01396.19 KPI84912.1 - 5.4e-05 22.9 1.3 5.4e-05 22.9 1.3 5.0 5 0 0 5 5 5 1 Topoisomerase DNA binding C4 zinc finger Cys_rich_CPCC PF14206.6 KPI84912.1 - 0.029 14.2 0.9 0.11 12.4 0.9 2.0 1 0 0 1 1 1 0 Cysteine-rich CPCC zinc_ribbon_12 PF11331.8 KPI84912.1 - 0.15 11.8 0.1 0.15 11.8 0.1 4.9 4 1 1 5 5 5 0 Probable zinc-ribbon domain zf-ribbon_3 PF13248.6 KPI84912.1 - 2.9 7.4 14.7 2.2 7.8 0.1 5.5 6 0 0 6 6 6 0 zinc-ribbon domain 14-3-3 PF00244.20 KPI84913.1 - 3.4e-85 285.1 1.6 4e-85 284.8 1.6 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 KPI84913.1 - 0.053 13.8 2.4 0.13 12.5 0.6 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84913.1 - 7.4 7.0 6.6 5.4 7.4 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SAB PF04382.13 KPI84914.1 - 0.089 12.9 3.5 0.89 9.7 0.2 3.1 2 0 0 2 2 2 0 SAB domain Transposase_1 PF01359.18 KPI84914.1 - 0.9 9.4 7.8 0.38 10.6 0.4 3.7 3 0 0 3 3 3 0 Transposase (partial DDE domain) AcetDehyd-dimer PF09290.11 KPI84914.1 - 1.3 9.2 5.5 18 5.5 0.1 3.2 3 0 0 3 3 3 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation GMC_oxred_N PF00732.19 KPI84915.1 - 1.7e-49 168.8 0.0 2.5e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KPI84915.1 - 9e-18 65.2 0.1 1.7e-17 64.3 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 KPI84915.1 - 1.5e-09 38.0 6.4 0.00042 20.0 0.7 3.2 2 1 1 3 3 3 3 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KPI84915.1 - 2.1e-07 30.4 7.8 0.00077 18.7 2.9 2.5 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 KPI84915.1 - 2.8e-06 26.8 0.3 0.0016 17.7 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI84915.1 - 0.00012 22.2 1.5 0.0015 18.8 0.9 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 KPI84915.1 - 0.0004 19.6 0.1 0.025 13.7 0.2 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 KPI84915.1 - 0.0012 18.3 5.3 0.084 12.2 3.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 KPI84915.1 - 0.003 16.8 1.1 0.011 15.0 0.3 2.0 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 KPI84915.1 - 0.013 14.3 0.9 0.071 11.8 0.9 1.9 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 KPI84915.1 - 0.014 14.4 0.6 0.014 14.4 0.6 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 KPI84915.1 - 0.026 13.8 0.0 2.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KPI84915.1 - 0.12 11.2 0.5 0.98 8.2 0.1 2.2 3 0 0 3 3 3 0 Tryptophan halogenase DUF3439 PF11921.8 KPI84917.1 - 0.55 10.2 5.3 1.6 8.7 5.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ribosomal_L20 PF00453.18 KPI84919.1 - 0.0037 17.3 1.1 0.0057 16.7 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L20 DUF4124 PF13511.6 KPI84920.1 - 7.7 6.9 9.6 2.3 8.6 0.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4124) Peptidase_M20 PF01546.28 KPI84921.1 - 3.1e-16 59.7 0.2 3.8e-16 59.4 0.2 1.0 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 KPI84921.1 - 0.08 11.9 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 KPI84921.1 - 0.11 12.2 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M28 Pyr_redox_2 PF07992.14 KPI84923.1 - 2e-42 145.4 0.3 2.9e-42 144.9 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KPI84923.1 - 1.2e-19 70.6 0.4 3.5e-19 69.1 0.0 2.1 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KPI84923.1 - 3e-15 56.6 2.8 7.1e-12 45.7 0.1 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KPI84923.1 - 2.3e-11 43.7 0.6 4.7e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 KPI84923.1 - 8.6e-09 35.4 3.3 1.2e-06 28.4 0.0 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 KPI84923.1 - 1.4e-07 31.0 4.7 6.3e-06 25.5 1.2 3.0 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 KPI84923.1 - 1.7e-07 31.3 1.5 0.012 15.8 0.4 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KPI84923.1 - 3.7e-07 29.2 3.8 2.2e-05 23.4 0.1 3.6 3 1 0 4 4 4 1 HI0933-like protein FAD_binding_2 PF00890.24 KPI84923.1 - 6.1e-07 28.9 0.8 6.1e-07 28.9 0.8 2.6 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 KPI84923.1 - 4.2e-06 26.2 0.8 0.0013 18.1 0.0 2.8 3 0 0 3 3 3 1 Thi4 family Lycopene_cycl PF05834.12 KPI84923.1 - 4.6e-05 22.6 0.2 0.0035 16.5 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 KPI84923.1 - 0.00018 20.9 10.6 0.0027 17.0 0.4 3.0 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KPI84923.1 - 0.00022 20.6 0.2 0.33 10.2 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 KPI84923.1 - 0.00029 20.1 0.4 0.027 13.6 0.2 2.9 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 KPI84923.1 - 0.00034 20.0 2.9 0.023 14.0 0.5 3.2 2 1 0 2 2 2 1 FAD binding domain ThiF PF00899.21 KPI84923.1 - 0.00082 18.8 0.1 0.0023 17.3 0.1 1.7 1 0 0 1 1 1 1 ThiF family NAD_binding_9 PF13454.6 KPI84923.1 - 0.0095 15.9 0.7 0.34 10.9 0.0 3.2 2 2 0 2 2 2 1 FAD-NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 KPI84923.1 - 0.041 13.4 0.3 0.42 10.2 0.0 2.3 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Trp_halogenase PF04820.14 KPI84923.1 - 0.084 11.7 1.9 0.26 10.1 0.1 2.4 3 0 0 3 3 3 0 Tryptophan halogenase PglD_N PF17836.1 KPI84923.1 - 0.19 12.4 0.4 24 5.7 0.2 2.9 3 0 0 3 3 2 0 PglD N-terminal domain TrkA_N PF02254.18 KPI84923.1 - 0.72 10.1 2.6 4.2 7.7 0.2 3.0 4 0 0 4 4 3 0 TrkA-N domain Pyr_redox_2 PF07992.14 KPI84924.1 - 6.1e-44 150.4 0.2 7.5e-44 150.1 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KPI84924.1 - 1.3e-17 64.0 0.2 4.4e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KPI84924.1 - 7.2e-16 58.5 1.4 1.1e-12 48.3 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KPI84924.1 - 6.7e-10 38.9 1.9 6.8e-10 38.9 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KPI84924.1 - 3e-08 33.3 3.0 0.0011 18.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI84924.1 - 4.3e-06 25.7 3.8 0.0027 16.5 0.2 3.2 3 0 0 3 3 3 2 HI0933-like protein NAD_binding_8 PF13450.6 KPI84924.1 - 1.1e-05 25.6 5.7 0.0063 16.7 1.3 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 KPI84924.1 - 1.6e-05 24.1 0.1 0.017 14.2 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein GIDA PF01134.22 KPI84924.1 - 1.7e-05 24.1 4.2 0.04 13.0 0.9 3.3 3 1 0 3 3 3 2 Glucose inhibited division protein A ThiF PF00899.21 KPI84924.1 - 0.00026 20.5 0.0 0.00084 18.8 0.0 1.8 2 0 0 2 2 2 1 ThiF family FAD_binding_2 PF00890.24 KPI84924.1 - 0.00031 20.0 7.2 0.001 18.2 1.0 3.0 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 KPI84924.1 - 0.00081 18.7 0.5 0.077 12.2 0.1 2.4 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 KPI84924.1 - 0.00098 18.3 0.6 0.0068 15.6 0.0 2.3 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 KPI84924.1 - 0.0011 18.7 7.9 0.23 11.0 2.6 3.3 2 1 0 3 3 3 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KPI84924.1 - 0.0023 17.3 0.4 1.6 8.0 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Peptidase_C34 PF05413.11 KPI84924.1 - 0.0075 16.5 0.1 0.018 15.3 0.1 1.6 1 0 0 1 1 1 1 Putative closterovirus papain-like endopeptidase TrkA_N PF02254.18 KPI84924.1 - 0.0083 16.4 0.6 0.14 12.5 0.1 2.9 2 0 0 2 2 2 1 TrkA-N domain FAD_binding_3 PF01494.19 KPI84924.1 - 0.01 15.1 1.2 0.051 12.8 0.1 2.4 3 0 0 3 3 3 0 FAD binding domain 3HCDH_N PF02737.18 KPI84924.1 - 0.027 14.4 1.7 0.033 14.1 0.1 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 KPI84924.1 - 0.058 13.4 1.6 3.2 7.7 0.2 3.4 2 2 1 3 3 3 0 FAD-NAD(P)-binding Sacchrp_dh_NADP PF03435.18 KPI84924.1 - 0.098 12.9 0.1 0.48 10.7 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 KPI84924.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 KPI84924.1 - 1.3 8.6 4.6 2.3 7.8 0.1 2.7 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Metallophos PF00149.28 KPI84925.1 - 2.2e-36 126.3 0.1 2.9e-36 125.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI84925.1 - 4.5e-08 33.4 0.0 2.3e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain CRCB PF02537.15 KPI84926.1 - 1.5e-24 86.1 18.9 1.3e-13 51.0 6.9 2.5 2 1 1 3 3 3 2 CrcB-like protein, Camphor Resistance (CrcB) DUF747 PF05346.11 KPI84926.1 - 0.088 12.3 1.0 0.38 10.2 1.0 2.1 1 1 0 1 1 1 0 Eukaryotic membrane protein family RNA_pol_Rpb1_5 PF04998.17 KPI84927.1 - 1.3e-96 323.2 0.3 1.9e-96 322.6 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 KPI84927.1 - 8.3e-96 321.0 0.1 1.2e-94 317.1 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 KPI84927.1 - 2.9e-70 235.8 0.5 6.2e-70 234.7 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 KPI84927.1 - 5.6e-49 166.6 2.0 1.1e-48 165.6 2.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 KPI84927.1 - 4.7e-39 133.8 0.0 1.1e-38 132.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KPI84927.1 - 6.2e-29 100.1 0.1 1.9e-28 98.6 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_7 PF04990.12 KPI84927.1 - 1.7e-20 73.4 0.2 4.4e-20 72.1 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 PspA_IM30 PF04012.12 KPI84927.1 - 0.03 13.9 1.8 0.074 12.6 1.8 1.6 1 0 0 1 1 1 0 PspA/IM30 family Calreticulin PF00262.18 KPI84928.1 - 5.1e-77 259.2 17.0 1.2e-55 188.9 3.2 2.1 1 1 1 2 2 2 2 Calreticulin family Ribosomal_60s PF00428.19 KPI84928.1 - 0.0013 19.2 8.5 0.0034 17.9 8.5 1.8 1 0 0 1 1 1 1 60s Acidic ribosomal protein TerD PF02342.18 KPI84929.1 - 3.6e-14 52.7 0.0 0.0005 19.6 0.0 3.3 3 0 0 3 3 3 3 TerD domain UCR_hinge PF02320.16 KPI84930.1 - 8.3e-18 64.4 2.7 9.3e-18 64.2 2.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein OHA PF14418.6 KPI84932.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 OST-HTH Associated domain Rrn6 PF10214.9 KPI84933.1 - 0.021 13.3 4.7 0.033 12.7 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Cyt-b5 PF00173.28 KPI84935.1 - 4.9e-19 68.2 0.0 9.9e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MORN PF02493.20 KPI84936.1 - 1.7e-46 153.4 111.1 3.6e-05 23.4 0.5 23.8 26 0 0 26 26 26 16 MORN repeat FYVE PF01363.21 KPI84936.1 - 5.3e-26 90.6 13.4 9.7e-19 67.3 1.9 2.6 2 0 0 2 2 2 2 FYVE zinc finger DUF3048_C PF17479.2 KPI84936.1 - 0.2 12.1 4.7 5.7 7.4 0.1 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain zf-CRD PF17979.1 KPI84936.1 - 0.21 11.7 11.4 1.5 8.9 1.7 2.7 2 0 0 2 2 2 0 Cysteine rich domain with multizinc binding regions FYVE_2 PF02318.16 KPI84936.1 - 0.38 11.0 12.1 0.86 9.8 2.5 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger DnaJ PF00226.31 KPI84937.1 - 2.1e-19 69.4 1.8 4.6e-19 68.3 1.8 1.6 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 KPI84938.1 - 2.1e-15 56.8 11.3 0.00032 21.4 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat WWE PF02825.20 KPI84938.1 - 7.4e-10 39.3 0.0 1.7e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 WWE domain ANAPC4_WD40 PF12894.7 KPI84938.1 - 0.0044 17.3 0.1 11 6.5 0.0 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4148 PF13663.6 KPI84940.1 - 4.5 7.5 8.9 3.1 8.0 4.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Prefoldin PF02996.17 KPI84941.1 - 5.4e-28 97.3 1.2 7.7e-28 96.8 0.8 1.5 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 KPI84941.1 - 0.00033 20.6 3.0 0.1 12.5 0.1 2.4 2 1 0 2 2 2 2 Prefoldin subunit End3 PF12761.7 KPI84941.1 - 0.0092 16.2 1.9 0.7 10.0 0.4 2.3 2 0 0 2 2 2 2 Actin cytoskeleton-regulatory complex protein END3 SKA2 PF16740.5 KPI84941.1 - 0.011 15.5 0.6 0.15 11.8 0.0 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 YabA PF06156.13 KPI84941.1 - 0.9 10.2 4.8 17 6.1 2.8 2.3 2 0 0 2 2 2 0 Initiation control protein YabA MMR_HSR1 PF01926.23 KPI84942.1 - 2.2e-15 56.7 0.0 2.4e-13 50.2 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI84942.1 - 1.8e-05 24.3 0.1 0.0004 20.0 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KPI84942.1 - 0.00024 21.0 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KPI84942.1 - 0.61 10.1 8.6 1 9.4 0.2 3.5 2 1 1 3 3 3 0 Dynamin family DivIC PF04977.15 KPI84942.1 - 3.3 7.5 5.1 46 3.9 2.4 2.6 2 0 0 2 2 2 0 Septum formation initiator FUSC_2 PF13515.6 KPI84943.1 - 7.2e-06 26.1 9.0 7.2e-06 26.1 9.0 2.5 2 0 0 2 2 2 2 Fusaric acid resistance protein-like ALMT PF11744.8 KPI84943.1 - 0.01 14.7 2.5 0.064 12.1 1.3 2.4 2 0 0 2 2 2 0 Aluminium activated malate transporter CoA_binding_3 PF13727.6 KPI84943.1 - 0.37 10.8 3.1 1.2 9.1 3.1 1.8 1 0 0 1 1 1 0 CoA-binding domain Thioredoxin PF00085.20 KPI84944.1 - 0.045 13.7 0.0 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin TraC_F_IV PF11130.8 KPI84944.1 - 0.069 12.8 5.1 0.27 10.8 0.8 3.0 2 1 1 3 3 3 0 F pilus assembly Type-IV secretion system for plasmid transfer AIG2_2 PF13772.6 KPI84946.1 - 1.6e-07 31.6 0.0 6.6e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 AIG2-like family GGACT PF06094.12 KPI84946.1 - 1.8e-07 31.8 0.0 0.0031 18.1 0.0 3.2 2 2 0 2 2 2 2 Gamma-glutamyl cyclotransferase, AIG2-like DAO PF01266.24 KPI84947.1 - 1.1e-14 54.8 2.9 9.7e-13 48.4 2.0 3.4 2 2 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KPI84947.1 - 1.1e-08 34.9 0.7 1.6e-08 34.3 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KPI84947.1 - 1.6e-07 30.8 0.3 2.5e-07 30.2 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KPI84947.1 - 1.8e-06 28.0 0.2 5.1e-06 26.6 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO_C PF16901.5 KPI84947.1 - 3.1e-06 27.1 0.9 1.1e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase Pyr_redox_2 PF07992.14 KPI84947.1 - 0.00019 20.8 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI84947.1 - 0.00032 19.5 1.1 0.00055 18.7 1.1 1.3 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 KPI84947.1 - 0.0011 18.1 0.2 0.0016 17.6 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KPI84947.1 - 0.017 14.4 0.5 0.031 13.5 0.5 1.4 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 KPI84947.1 - 0.025 13.7 0.1 0.039 13.0 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 KPI84947.1 - 0.2 12.3 1.3 0.51 10.9 1.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_8 PF05148.15 KPI84948.1 - 2.2e-52 178.1 0.0 2.9e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 KPI84948.1 - 1.3e-06 29.0 0.1 2e-05 25.1 0.1 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI84948.1 - 4.3e-05 24.1 0.1 0.0097 16.6 0.1 2.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI84948.1 - 0.0068 15.8 0.0 0.02 14.2 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PKcGMP_CC PF16808.5 KPI84949.1 - 4.7 7.2 14.6 0.12 12.3 0.3 4.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sfi1 PF08457.10 KPI84950.1 - 0.082 11.4 0.2 0.17 10.4 0.0 1.5 2 0 0 2 2 2 0 Sfi1 spindle body protein Rad1 PF02144.16 KPI84952.1 - 8.1e-08 31.7 0.0 2.3e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 NUDIX PF00293.28 KPI84953.1 - 0.0021 18.1 1.3 14 5.7 0.0 4.0 3 2 0 3 3 3 2 NUDIX domain DUF2171 PF09939.9 KPI84953.1 - 0.18 12.1 0.1 0.39 11.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2171) Metallophos PF00149.28 KPI84954.1 - 0.00096 19.7 0.1 0.0024 18.4 0.1 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Cellulase PF00150.18 KPI84954.1 - 0.052 13.0 0.0 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) Cas3_C PF18395.1 KPI84954.1 - 0.13 12.8 0.0 0.35 11.4 0.0 1.7 1 0 0 1 1 1 0 Cas3 C-terminal domain PRIMA1 PF16101.5 KPI84954.1 - 6.5 6.8 9.2 32 4.6 0.9 3.8 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Metallophos PF00149.28 KPI84955.1 - 0.004 17.7 0.7 0.015 15.8 0.2 2.2 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Shisa PF13908.6 KPI84956.1 - 0.00012 22.4 0.0 0.0002 21.7 0.0 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMIE PF16038.5 KPI84956.1 - 0.064 13.1 2.1 0.11 12.4 2.1 1.3 1 0 0 1 1 1 0 TMIE protein Comm PF15957.5 KPI84956.1 - 0.071 13.5 0.2 0.16 12.3 0.2 1.5 1 0 0 1 1 1 0 Commissureless MFS_1 PF07690.16 KPI84958.1 - 3.6e-23 82.0 47.7 7.6e-16 58.0 4.7 2.5 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF872 PF05915.12 KPI84958.1 - 5.1 7.3 5.8 3.3 7.9 0.8 3.2 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) Stealth_CR2 PF11380.8 KPI84959.1 - 8.4e-08 32.4 0.0 1.7e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 KPI84960.1 - 5.9e-11 42.1 2.2 1.3e-10 41.0 2.2 1.6 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Ufm1 PF03671.14 KPI84961.1 - 5.4e-35 119.3 0.1 6.4e-35 119.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Polyketide_cyc PF03364.20 KPI84968.1 - 9.6e-10 38.8 1.4 7.5e-09 35.9 1.4 2.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Hamartin PF04388.12 KPI84968.1 - 1.6 7.3 6.1 2 6.9 6.1 1.1 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 KPI84968.1 - 2.1 8.3 7.3 2.6 8.0 7.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit KIAA1328 PF15369.6 KPI84968.1 - 2.3 8.0 5.1 3.4 7.4 5.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Amastin PF07344.11 KPI84969.1 - 4.6e-06 26.6 0.0 1.1e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Amastin surface glycoprotein DUF2207 PF09972.9 KPI84969.1 - 0.026 13.3 0.4 2.1 7.0 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3273 PF11677.8 KPI84969.1 - 0.054 12.8 1.2 0.17 11.1 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3273) Anoctamin PF04547.12 KPI84969.1 - 0.055 12.3 0.1 0.086 11.7 0.1 1.3 1 0 0 1 1 1 0 Calcium-activated chloride channel SUR7 PF06687.12 KPI84969.1 - 0.35 10.5 0.0 0.35 10.5 0.0 2.7 2 1 1 3 3 3 0 SUR7/PalI family DUF4064 PF13273.6 KPI84969.1 - 1.4 9.2 0.0 1.4 9.2 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Pex14_N PF04695.13 KPI84969.1 - 1.5 9.5 8.2 1.6 9.4 5.1 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IncE PF17627.2 KPI84969.1 - 3.1 7.8 5.0 2 8.5 1.4 2.1 2 0 0 2 2 2 0 Inclusion membrane protein E DUF2975 PF11188.8 KPI84969.1 - 6.1 6.7 9.0 1.5 8.7 3.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) tRNA_bind PF01588.20 KPI84972.1 - 3.7e-22 78.3 0.0 6.9e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain Gly_kinase PF02595.15 KPI84977.1 - 4.3e-39 134.5 12.2 1.1e-27 97.0 12.1 7.0 2 1 1 3 3 3 3 Glycerate kinase family LCE PF14672.6 KPI84977.1 - 7.1 7.3 7.7 0.68 10.6 1.1 2.8 2 0 0 2 2 2 0 Late cornified envelope SLX9 PF15341.6 KPI84979.1 - 0.023 15.1 14.5 0.94 9.9 14.5 2.5 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 RR_TM4-6 PF06459.12 KPI84979.1 - 3.1 7.5 9.2 4.2 7.1 9.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S64 PF08192.11 KPI84979.1 - 7.5 4.9 9.1 8.7 4.7 9.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Porin_3 PF01459.22 KPI84981.1 - 5.1e-08 32.7 0.0 7.3e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 Eukaryotic porin Alfin PF12165.8 KPI84981.1 - 0.071 12.8 0.1 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 Alfin Porin_3 PF01459.22 KPI84982.1 - 1.3e-06 28.1 0.1 1.8e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic porin Glyco_hydro_20b PF02838.15 KPI84982.1 - 0.026 15.3 0.0 0.054 14.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 DUF913 PF06025.12 KPI84983.1 - 0.037 13.0 0.0 0.082 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PRKCSH-like PF12999.7 KPI84984.1 - 3.3e-08 33.5 0.0 2.7e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Glucosidase II beta subunit-like Ribosomal_L23eN PF03939.13 KPI84984.1 - 0.08 13.2 2.6 3.3 8.0 0.2 2.6 2 0 0 2 2 2 0 Ribosomal protein L23, N-terminal domain Peptidase_S51 PF03575.17 KPI84985.1 - 2e-21 76.6 0.0 6.7e-20 71.6 0.0 2.1 1 1 0 1 1 1 1 Peptidase family S51 UvrD-helicase PF00580.21 KPI84986.1 - 3e-39 135.4 0.0 5.5e-37 128.0 0.0 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 KPI84986.1 - 3.5e-27 95.7 0.0 7.6e-14 51.8 0.0 2.3 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KPI84986.1 - 3.9e-25 88.9 0.0 1.3e-24 87.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KPI84986.1 - 1.7e-08 34.1 0.0 4.1e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KPI84986.1 - 4.2e-08 33.1 0.2 0.00031 20.5 0.1 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 KPI84986.1 - 0.0066 16.2 0.0 8.2 6.1 0.0 3.4 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase G-gamma PF00631.22 KPI84986.1 - 0.048 13.7 0.0 3.6 7.7 0.0 2.5 2 0 0 2 2 2 0 GGL domain LRR_8 PF13855.6 KPI84987.1 - 4e-10 39.3 0.4 4.7e-05 23.1 0.1 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI84987.1 - 1.8e-06 28.2 4.0 0.035 14.5 0.2 3.8 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI84987.1 - 0.001 19.3 4.0 4.7 8.1 0.0 5.1 6 0 0 6 6 6 1 Leucine Rich Repeat LRRNT_2 PF08263.12 KPI84987.1 - 0.031 14.6 0.6 0.031 14.6 0.6 3.1 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 KPI84987.1 - 0.31 11.2 8.7 5.3 7.4 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich repeat PBP1_TM PF14812.6 KPI84988.1 - 0.18 12.2 1.9 0.48 10.8 1.9 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L16 PF00252.18 KPI84989.1 - 2e-15 57.0 0.0 2.4e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e PAP_assoc PF03828.19 KPI84990.1 - 2.4e-15 56.5 0.3 2.8e-14 53.0 0.1 2.7 2 1 0 2 2 2 1 Cid1 family poly A polymerase HTH_33 PF13592.6 KPI84990.1 - 0.02 14.6 0.0 9.3 6.0 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn helix NTP_transf_2 PF01909.23 KPI84990.1 - 0.055 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF2379 PF09543.10 KPI84990.1 - 0.15 12.3 1.3 0.39 10.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) AAA_18 PF13238.6 KPI84991.1 - 5.9e-08 33.3 0.0 0.013 16.0 0.0 2.4 2 1 0 2 2 2 2 AAA domain PRK PF00485.18 KPI84991.1 - 4.1e-05 23.4 0.0 0.021 14.6 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family dNK PF01712.19 KPI84991.1 - 0.00011 22.1 0.0 0.4 10.5 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_25 PF13481.6 KPI84991.1 - 0.00031 20.4 0.0 0.00055 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI84991.1 - 0.00068 20.1 0.0 0.00094 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 KPI84991.1 - 0.0008 18.7 0.0 0.005 16.1 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 KPI84991.1 - 0.0028 17.8 0.0 0.2 11.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KPI84991.1 - 0.0078 16.6 0.0 3.2 8.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KPI84991.1 - 0.015 15.7 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 KPI84991.1 - 0.015 15.8 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 KPI84991.1 - 0.017 15.2 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 KPI84991.1 - 0.03 14.2 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 KPI84991.1 - 0.035 13.3 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain KTI12 PF08433.10 KPI84991.1 - 0.043 13.2 0.0 0.093 12.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_30 PF13604.6 KPI84991.1 - 0.046 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KPI84991.1 - 0.051 13.3 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Ploopntkinase3 PF18751.1 KPI84991.1 - 0.062 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DUF3987 PF13148.6 KPI84991.1 - 0.079 12.0 0.9 0.42 9.6 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3987) Cytidylate_kin2 PF13189.6 KPI84991.1 - 0.086 13.0 0.4 1.5 8.9 0.1 2.3 2 0 0 2 2 2 0 Cytidylate kinase-like family Thymidylate_kin PF02223.17 KPI84991.1 - 0.13 11.9 0.0 7 6.3 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase AAA_22 PF13401.6 KPI84991.1 - 0.15 12.3 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI84991.1 - 0.17 11.6 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 KPI84991.1 - 0.19 11.7 0.0 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 NTPase Na_H_Exchanger PF00999.21 KPI84992.1 - 2.6e-18 66.0 21.5 4.2e-18 65.3 21.5 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Mito_carr PF00153.27 KPI84993.1 - 1.4e-26 92.3 0.1 2e-10 40.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 KPI84995.1 - 0.0015 18.4 0.0 0.47 10.4 0.0 3.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Pox_MCEL PF03291.16 KPI84998.1 - 3.7e-17 62.4 0.0 6.5e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 KPI84998.1 - 1.9e-07 31.7 0.0 5.1e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI84998.1 - 1.3e-05 25.8 0.0 2.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI84998.1 - 2.5e-05 24.8 0.0 6.9e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI84998.1 - 0.00098 19.0 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PAM2 PF07145.15 KPI84998.1 - 0.02 14.6 0.9 0.084 12.6 0.8 2.2 2 0 0 2 2 2 0 Ataxin-2 C-terminal region Methyltransf_32 PF13679.6 KPI84998.1 - 0.039 13.9 0.0 0.084 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KPI84998.1 - 0.048 13.2 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain TPR_1 PF00515.28 KPI84999.1 - 3.2e-22 77.3 4.7 7.5e-07 28.7 0.2 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 KPI84999.1 - 3.7e-19 67.2 3.7 4.2e-05 23.4 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI84999.1 - 1.2e-13 50.4 5.3 3.8e-06 26.5 0.0 4.9 4 1 1 5 5 5 3 TPR repeat TPR_12 PF13424.6 KPI84999.1 - 2e-11 44.0 0.5 0.0081 16.4 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI84999.1 - 5.8e-11 41.7 8.6 0.0011 19.0 0.2 6.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 KPI84999.1 - 9.4e-11 41.0 0.6 0.00054 19.8 0.1 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 KPI84999.1 - 1.7e-08 34.6 1.7 0.063 13.9 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI84999.1 - 1.2e-07 31.6 0.9 0.033 14.6 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI84999.1 - 2e-06 28.3 0.0 0.16 12.7 0.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI84999.1 - 1.1e-05 25.8 6.9 0.044 14.6 0.0 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI84999.1 - 6.1e-05 23.4 3.0 1.1 9.8 0.0 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 KPI84999.1 - 0.00096 18.4 0.1 0.16 11.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KPI84999.1 - 0.063 13.2 4.0 0.61 10.0 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 KPI84999.1 - 1.3 9.1 6.5 17 5.6 0.1 3.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 KPI84999.1 - 5.3 6.7 5.8 10 5.8 0.1 3.5 4 0 0 4 4 4 0 26S proteasome subunit RPN7 Pkinase PF00069.25 KPI85001.1 - 3.9e-26 92.0 0.0 7.1e-26 91.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85001.1 - 2.4e-11 43.4 0.0 5.3e-10 39.0 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI85001.1 - 0.013 14.2 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 KPI85001.1 - 0.17 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 KPI85001.1 - 0.2 10.9 0.1 0.42 9.9 0.1 1.4 1 1 0 1 1 1 0 Kinase-like AA_permease_2 PF13520.6 KPI85002.1 - 2.1e-19 69.7 42.5 3.6e-19 68.9 42.5 1.3 1 0 0 1 1 1 1 Amino acid permease DUF563 PF04577.14 KPI85004.1 - 7e-14 52.5 0.7 2.3e-13 50.8 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF563) Nucleoside_tran PF01733.18 KPI85005.1 - 4.4e-21 75.6 7.2 5.3e-16 58.9 0.1 2.5 3 0 0 3 3 3 2 Nucleoside transporter Deltameth_res PF16020.5 KPI85005.1 - 0.047 13.6 0.5 0.22 11.4 0.5 2.2 1 0 0 1 1 1 0 Deltamethrin resistance Nucleoside_tran PF01733.18 KPI85006.1 - 5.1e-39 134.5 6.8 9.9e-27 94.1 1.3 2.3 2 0 0 2 2 2 2 Nucleoside transporter Tex_N PF09371.10 KPI85007.1 - 1.1e-38 132.8 1.6 1.1e-38 132.8 1.6 1.8 2 0 0 2 2 2 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 KPI85007.1 - 7.3e-35 120.2 0.3 2.6e-34 118.4 0.1 2.1 2 0 0 2 2 2 1 Tex protein YqgF-like domain HHH_3 PF12836.7 KPI85007.1 - 2.2e-10 40.6 0.0 5.3e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 KPI85007.1 - 5.1e-10 40.1 0.1 2.3e-05 25.2 0.0 3.3 1 1 1 2 2 2 2 HHH domain YqgF PF14639.6 KPI85007.1 - 2.7e-06 27.2 0.1 9.9e-06 25.4 0.0 2.0 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 S1 PF00575.23 KPI85007.1 - 0.00082 19.7 1.7 0.0013 19.1 0.2 2.0 2 0 0 2 2 2 1 S1 RNA binding domain HHH_7 PF14635.6 KPI85007.1 - 0.037 14.4 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF655 PF04919.12 KPI85007.1 - 0.072 13.0 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF655) DUF4611 PF15387.6 KPI85007.1 - 1.3 9.3 5.8 1.4 9.1 1.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) TMEM208_SND2 PF05620.11 KPI85012.1 - 0.004 16.9 0.2 0.004 16.9 0.2 2.0 3 0 0 3 3 3 1 SRP-independent targeting protein 2/TMEM208 Cyt-b5 PF00173.28 KPI85013.1 - 8.3e-21 73.9 0.0 5.6e-19 68.1 0.0 2.1 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain RRM_1 PF00076.22 KPI85014.1 - 3.1e-12 46.1 0.0 1.1e-05 25.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI85014.1 - 0.0013 18.3 0.0 0.093 12.3 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KPI85014.1 - 0.011 15.9 1.0 5.8 7.2 0.2 2.7 2 1 0 2 2 2 0 RRM-like domain Clp1 PF06807.14 KPI85014.1 - 0.046 14.1 0.3 0.72 10.3 0.0 2.8 2 1 0 2 2 2 0 Pre-mRNA cleavage complex II protein Clp1 RRM_1 PF00076.22 KPI85015.1 - 3.8e-17 61.9 0.0 5.7e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI85015.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif TPR_2 PF07719.17 KPI85017.1 - 9.2e-06 25.4 9.3 3.3 8.1 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85017.1 - 2.9e-05 24.3 27.3 0.0012 19.1 1.9 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI85017.1 - 0.00015 21.5 10.4 8 6.5 0.1 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85017.1 - 1.6 9.1 10.6 6.4 7.3 0.3 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI85017.1 - 2.1 9.4 14.0 0.62 11.0 0.4 6.1 6 1 1 7 7 7 0 Tetratricopeptide repeat ubiquitin PF00240.23 KPI85018.1 - 0.0002 21.0 0.0 0.069 12.9 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin family PRA1 PF03208.19 KPI85020.1 - 3.1e-19 69.0 3.6 4.9e-19 68.4 3.6 1.2 1 0 0 1 1 1 1 PRA1 family protein DUF1980 PF09323.10 KPI85020.1 - 0.53 10.2 4.1 0.58 10.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) PRA1 PF03208.19 KPI85021.1 - 3e-25 88.5 10.3 4.1e-25 88.1 10.3 1.1 1 0 0 1 1 1 1 PRA1 family protein PET117 PF15786.5 KPI85022.1 - 0.00065 19.9 3.3 0.0045 17.2 3.3 2.5 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF1430 PF07242.11 KPI85022.1 - 0.3 11.3 5.7 10 6.4 1.6 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1430) DUF4064 PF13273.6 KPI85022.1 - 3.6 7.9 9.4 6.6 7.1 0.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) GST_C PF00043.25 KPI85023.1 - 1.7e-13 50.6 0.0 2.8e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KPI85023.1 - 1.3e-06 28.5 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KPI85023.1 - 3.9e-06 26.8 0.0 6.8e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KPI85023.1 - 3.2e-05 24.2 0.0 5.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 KPI85023.1 - 0.099 12.9 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Med27 PF11571.8 KPI85024.1 - 0.02 15.3 0.1 0.11 12.9 0.1 2.3 1 0 0 1 1 1 0 Mediator complex subunit 27 Mucin15 PF15672.5 KPI85024.1 - 1 8.7 3.4 1.1 8.7 0.4 2.4 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 DUF5327 PF17261.2 KPI85024.1 - 6.6 7.6 8.8 7.8 7.3 1.3 3.9 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Glyco_hydro_65m PF03632.15 KPI85025.1 - 8.2e-68 229.0 0.0 1.5e-67 228.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 KPI85025.1 - 3.7e-27 95.4 0.1 6.6e-27 94.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.15 KPI85025.1 - 0.00093 19.1 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain HAD_2 PF13419.6 KPI85025.1 - 0.0076 16.4 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NeA_P2 PF12312.8 KPI85026.1 - 0.17 11.3 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein SGL PF08450.12 KPI85028.1 - 0.02 14.5 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region HTH_20 PF12840.7 KPI85029.1 - 0.69 10.0 7.4 5.2 7.2 0.2 3.7 4 0 0 4 4 4 0 Helix-turn-helix domain SNF2_N PF00176.23 KPI85030.1 - 4e-62 210.0 0.2 8.7e-62 208.9 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI85030.1 - 1.1e-18 67.6 0.0 2.2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KPI85030.1 - 0.00018 20.8 0.1 0.0038 16.5 0.0 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 KPI85030.1 - 0.00031 20.5 0.0 0.0007 19.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase FYDLN_acid PF09538.10 KPI85030.1 - 5.9 7.6 9.3 1.8 9.2 1.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Aldedh PF00171.22 KPI85031.1 - 1.3e-126 422.8 0.1 1.5e-126 422.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Mg_chelatase PF01078.21 KPI85031.1 - 0.12 11.7 0.1 0.21 11.0 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI VPS28 PF03997.12 KPI85032.1 - 1.1e-43 149.1 0.1 1.3e-43 148.9 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein Acyl-CoA_ox_N PF14749.6 KPI85032.1 - 0.068 13.7 0.0 0.25 11.9 0.0 1.9 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Phage_Mu_Gam PF07352.12 KPI85032.1 - 0.076 12.9 0.2 0.12 12.3 0.2 1.2 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein MA3 PF02847.17 KPI85033.1 - 1.4e-13 50.9 1.2 4.1e-13 49.3 1.2 1.8 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 KPI85033.1 - 4.2e-08 33.1 2.6 1.2e-07 31.6 0.2 2.4 2 0 0 2 2 2 1 MIF4G domain DUF3400 PF11880.8 KPI85033.1 - 0.04 13.4 0.1 2.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3400) Kinesin PF00225.23 KPI85034.1 - 5.9e-20 71.5 2.4 1.2e-15 57.2 0.0 3.3 3 1 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 KPI85034.1 - 3e-06 27.2 2.0 1.4e-05 25.0 0.0 3.2 3 2 0 3 3 3 1 Microtubule binding Fib_alpha PF08702.10 KPI85034.1 - 0.052 13.7 0.5 0.052 13.7 0.5 3.6 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family VHS PF00790.19 KPI85035.1 - 4.2e-10 39.6 0.0 7e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 VHS domain Porin_3 PF01459.22 KPI85036.1 - 0.0039 16.7 0.3 0.015 14.8 0.3 2.1 1 1 0 1 1 1 1 Eukaryotic porin NYD-SP28 PF14772.6 KPI85037.1 - 0.00033 20.7 7.3 0.00078 19.4 0.4 2.8 2 1 1 3 3 3 2 Sperm tail RepB PF07506.11 KPI85037.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 RepB plasmid partitioning protein ATG16 PF08614.11 KPI85037.1 - 0.016 15.4 4.7 0.021 15.0 4.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) PAXX PF15384.6 KPI85037.1 - 0.044 13.5 0.5 0.066 12.9 0.5 1.2 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Het-C PF07217.11 KPI85037.1 - 0.053 12.1 0.4 0.065 11.8 0.4 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C LpqV PF17301.2 KPI85037.1 - 0.27 11.5 2.9 0.56 10.5 0.0 2.3 1 1 1 2 2 2 0 Putative lipoprotein LpqV DUF4126 PF13548.6 KPI85039.1 - 0.018 14.8 3.3 0.027 14.1 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4126) Glutaredoxin PF00462.24 KPI85041.1 - 7.1e-11 42.2 0.0 9.8e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin SH3BGR PF04908.15 KPI85041.1 - 0.11 12.7 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein Nop14 PF04147.12 KPI85042.1 - 0.031 12.5 25.9 0.047 11.9 25.9 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 KPI85042.1 - 0.25 11.1 23.7 0.59 9.8 23.7 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF1358 PF07096.11 KPI85046.1 - 3.1e-05 23.9 0.1 5.6e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) ATP-synt_C PF00137.21 KPI85048.1 - 7.3e-09 35.8 13.5 1.4e-08 34.9 13.5 1.5 1 0 0 1 1 1 1 ATP synthase subunit C ATP_transf PF09830.9 KPI85048.1 - 0.073 13.2 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 ATP adenylyltransferase DUF2474 PF10617.9 KPI85049.1 - 0.048 13.5 0.4 0.19 11.6 0.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) HEAT_2 PF13646.6 KPI85049.1 - 0.23 11.9 3.1 2.4 8.6 0.0 4.3 5 0 0 5 5 5 0 HEAT repeats ATP_bind_1 PF03029.17 KPI85050.1 - 3.4e-50 171.1 0.0 8.5e-46 156.7 0.0 2.9 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 KPI85050.1 - 0.0099 16.2 0.0 0.13 12.6 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 KPI85050.1 - 0.013 15.7 0.0 0.046 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KPI85050.1 - 0.015 15.9 3.3 0.051 14.1 0.2 2.9 2 2 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KPI85050.1 - 0.063 13.7 1.5 0.43 11.0 0.2 2.8 4 0 0 4 4 4 0 AAA domain GTP_EFTU PF00009.27 KPI85050.1 - 0.068 12.7 0.0 1.1 8.8 0.0 2.6 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA PF00004.29 KPI85050.1 - 0.19 12.2 0.1 0.69 10.3 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ribosomal_S7 PF00177.21 KPI85050.1 - 0.73 9.5 3.8 0.21 11.2 0.3 1.8 2 0 0 2 2 2 0 Ribosomal protein S7p/S5e PAP_assoc PF03828.19 KPI85051.1 - 2.7e-05 24.3 0.0 5.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KPI85051.1 - 0.0036 17.6 0.0 0.0068 16.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain FRB_dom PF08771.11 KPI85051.1 - 0.1 13.0 0.1 0.2 12.1 0.1 1.4 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain LRR_6 PF13516.6 KPI85052.1 - 1.8e-36 121.1 20.3 0.00051 19.9 0.1 12.9 13 0 0 13 13 13 10 Leucine Rich repeat LRR_1 PF00560.33 KPI85052.1 - 1.3e-08 34.2 3.6 11 7.0 0.0 8.6 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_4 PF12799.7 KPI85052.1 - 3.6e-06 27.2 16.3 0.057 13.9 0.3 6.7 5 2 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85052.1 - 0.0011 18.7 23.7 0.0072 16.1 1.8 7.8 5 1 3 8 8 8 2 Leucine rich repeat MAPKK1_Int PF08923.10 KPI85057.1 - 0.00086 19.1 0.0 0.037 13.9 0.0 2.1 1 1 1 2 2 2 2 Mitogen-activated protein kinase kinase 1 interacting DUF525 PF04379.14 KPI85058.1 - 9.5e-14 51.4 0.0 3.9e-13 49.4 0.0 1.9 2 0 0 2 2 2 1 ApaG domain Taxilin PF09728.9 KPI85060.1 - 0.19 10.9 50.4 0.33 10.1 50.4 1.4 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF4099 PF13351.6 KPI85060.1 - 0.27 11.5 2.4 0.55 10.5 0.0 2.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4099) Fib_alpha PF08702.10 KPI85060.1 - 0.85 9.8 30.9 0.036 14.3 7.4 3.6 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family ApoO PF09769.9 KPI85060.1 - 2.2 8.2 6.4 2.3 8.2 0.7 3.1 1 1 1 2 2 2 0 Apolipoprotein O ATG16 PF08614.11 KPI85060.1 - 8.5 6.6 50.1 1.4 9.1 23.5 3.4 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.12 KPI85060.1 - 8.6 6.4 10.8 3.6 7.6 0.2 3.6 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus PPR_2 PF13041.6 KPI85061.1 - 1.7e-13 50.6 2.6 3.5e-06 27.1 0.0 3.7 2 2 2 4 4 4 3 PPR repeat family PPR_3 PF13812.6 KPI85061.1 - 1.7e-09 37.6 0.1 1e-05 25.5 0.0 3.0 1 1 2 3 3 3 3 Pentatricopeptide repeat domain PPR_long PF17177.4 KPI85061.1 - 1.8e-09 37.2 0.2 7.8e-08 31.9 0.2 2.0 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KPI85061.1 - 3e-07 30.2 6.1 0.06 13.6 0.0 4.5 4 1 0 4 4 4 2 PPR repeat TPR_14 PF13428.6 KPI85061.1 - 0.0073 17.0 6.5 2.8 9.0 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85061.1 - 0.018 15.6 2.2 0.15 12.5 0.1 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat MNE1 PF13762.6 KPI85061.1 - 0.034 14.1 0.0 0.59 10.1 0.0 2.6 2 1 1 3 3 3 0 Mitochondrial splicing apparatus component RRM_1 PF00076.22 KPI85063.1 - 9.5e-12 44.6 0.0 1.9e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF725 PF05267.12 KPI85065.1 - 0.029 14.3 0.9 0.055 13.5 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF725) COPIIcoated_ERV PF07970.12 KPI85066.1 - 1.3e-62 211.5 0.0 1.7e-62 211.2 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KPI85066.1 - 1.2e-23 83.3 0.0 2.5e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF1002 PF06207.11 KPI85066.1 - 0.096 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) EMP24_GP25L PF01105.24 KPI85067.1 - 2.5e-32 112.3 0.0 3.4e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF998 PF06197.13 KPI85067.1 - 0.009 15.6 0.2 0.019 14.5 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF998) RCC1 PF00415.18 KPI85068.1 - 2.5e-25 88.8 13.1 3.6e-12 46.7 0.0 7.4 6 2 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI85068.1 - 2.3e-21 75.0 10.2 3.2e-05 23.6 0.0 4.9 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Bap31 PF05529.12 KPI85069.1 - 0.00026 20.9 3.7 0.00034 20.5 3.7 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region MWFE PF15879.5 KPI85069.1 - 0.55 10.4 3.0 14 6.0 0.0 2.5 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase MWFE subunit DUF1077 PF06417.12 KPI85069.1 - 0.98 9.4 4.2 32 4.6 4.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1077) MORN PF02493.20 KPI85070.1 - 2.4e-33 112.0 56.7 6.4e-08 32.1 1.1 8.5 9 0 0 9 9 9 7 MORN repeat Kinesin PF00225.23 KPI85070.1 - 1e-16 60.8 0.0 2.7e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain GIT_CC PF16559.5 KPI85070.1 - 0.00065 19.5 19.8 0.12 12.3 0.2 5.0 4 0 0 4 4 4 3 GIT coiled-coil Rho guanine nucleotide exchange factor Microtub_bd PF16796.5 KPI85070.1 - 0.00084 19.3 0.0 0.0026 17.7 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding DUF3048_C PF17479.2 KPI85070.1 - 0.23 11.8 6.3 0.38 11.1 0.4 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain DUF3584 PF12128.8 KPI85070.1 - 0.56 7.6 37.3 0.21 9.1 7.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) GSH_synthase PF03199.15 KPI85070.1 - 0.57 10.7 3.2 1.7 9.1 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic glutathione synthase DNA_pol_A_exo1 PF01612.20 KPI85071.1 - 2.6e-06 27.2 0.0 6.6e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 3'-5' exonuclease FAM163 PF15069.6 KPI85073.1 - 0.005 17.3 0.0 0.009 16.5 0.0 1.4 1 0 0 1 1 1 1 FAM163 family LRR_4 PF12799.7 KPI85075.1 - 1.8e-16 59.9 0.0 0.0019 18.6 0.0 6.0 5 2 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85075.1 - 0.0011 18.7 0.3 4.4 7.1 0.0 4.2 3 2 1 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 KPI85075.1 - 0.016 15.2 0.2 53 4.2 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat M20_dimer PF07687.14 KPI85076.1 - 0.023 14.6 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase dimerisation domain zf-CHCC PF10276.9 KPI85077.1 - 2.5e-05 24.2 0.5 2.5e-05 24.2 0.5 2.0 2 0 0 2 2 2 1 Zinc-finger domain PI-PLC-X PF00388.19 KPI85078.1 - 1.3e-55 187.0 0.0 3.6e-55 185.5 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KPI85078.1 - 7.2e-31 106.9 0.0 1.5e-30 105.9 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KPI85078.1 - 2.2e-15 56.8 0.4 6.5e-15 55.3 0.0 2.0 2 0 0 2 2 2 1 C2 domain EF-hand_7 PF13499.6 KPI85078.1 - 1e-10 41.9 1.3 1.2e-05 25.7 0.0 2.9 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KPI85078.1 - 1.3e-08 33.8 0.0 0.0025 17.3 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KPI85078.1 - 2e-07 30.4 0.1 0.001 18.8 0.1 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KPI85078.1 - 2.6e-06 26.7 0.1 0.069 12.7 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KPI85078.1 - 4e-06 26.6 2.0 4.5e-05 23.2 0.1 3.1 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_10 PF14788.6 KPI85078.1 - 3.5e-05 23.6 0.1 7e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_4 PF12763.7 KPI85078.1 - 0.029 14.3 0.0 1.5 8.8 0.1 2.6 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_like PF09279.11 KPI85078.1 - 0.038 14.5 0.1 0.087 13.3 0.1 1.6 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like SPARC_Ca_bdg PF10591.9 KPI85078.1 - 0.048 14.0 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KPI85078.1 - 0.059 13.6 0.0 0.19 11.9 0.0 1.9 1 0 0 1 1 1 0 Dockerin type I domain Stress-antifung PF01657.17 KPI85079.1 - 0.22 12.2 4.2 2.3 8.9 0.8 2.7 2 0 0 2 2 2 0 Salt stress response/antifungal Pkinase PF00069.25 KPI85082.1 - 1.8e-55 188.2 0.0 2.3e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85082.1 - 1.1e-19 70.8 0.0 1.6e-19 70.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI85082.1 - 1.9e-06 27.4 0.1 5e-06 26.0 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI85082.1 - 0.00054 19.9 0.0 0.00082 19.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI85082.1 - 0.0046 16.3 0.0 0.013 14.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI85082.1 - 0.034 12.9 0.1 0.078 11.7 0.1 1.5 2 0 0 2 2 2 0 Fungal protein kinase Aldedh PF00171.22 KPI85083.1 - 3.1e-120 401.8 0.0 3.9e-120 401.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KPI85083.1 - 0.018 14.5 0.0 0.035 13.6 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) PPR_2 PF13041.6 KPI85085.1 - 0.00029 21.0 0.0 11 6.3 0.0 5.0 5 0 0 5 5 5 1 PPR repeat family PPR PF01535.20 KPI85085.1 - 0.014 15.6 0.1 42 4.7 0.0 5.2 5 0 0 5 5 5 0 PPR repeat TPR_14 PF13428.6 KPI85085.1 - 0.063 14.1 17.2 5.3 8.1 0.1 8.3 8 2 2 10 10 10 0 Tetratricopeptide repeat FUN14 PF04930.15 KPI85086.1 - 5.6e-16 58.7 0.3 7.5e-16 58.3 0.3 1.2 1 0 0 1 1 1 1 FUN14 family EF-hand_5 PF13202.6 KPI85086.1 - 0.041 13.4 0.2 0.07 12.7 0.2 1.3 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 KPI85086.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 EF hand MS_channel PF00924.18 KPI85086.1 - 0.23 11.0 0.3 0.38 10.3 0.3 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel GAT PF03127.14 KPI85087.1 - 0.00028 21.1 0.0 0.00077 19.7 0.0 1.8 1 0 0 1 1 1 1 GAT domain AnfG_VnfG PF03139.15 KPI85087.1 - 0.065 13.3 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Vanadium/alternative nitrogenase delta subunit FUN14 PF04930.15 KPI85089.1 - 1e-05 25.8 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 FUN14 family RabGAP-TBC PF00566.18 KPI85092.1 - 3.4e-32 111.8 0.1 2e-31 109.3 0.1 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DDT PF02791.17 KPI85092.1 - 0.046 14.0 0.1 0.14 12.5 0.0 1.9 2 0 0 2 2 2 0 DDT domain Cpn60_TCP1 PF00118.24 KPI85094.1 - 1.2e-70 238.5 9.1 3.9e-70 236.9 9.1 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family SecG PF03840.14 KPI85096.1 - 0.14 12.2 0.3 0.28 11.3 0.3 1.4 1 0 0 1 1 1 0 Preprotein translocase SecG subunit DUF872 PF05915.12 KPI85097.1 - 2.6e-05 24.4 0.0 3.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) zf-CCCH PF00642.24 KPI85098.1 - 3e-07 30.2 1.5 3e-07 30.2 1.5 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI85098.1 - 0.00015 21.7 2.5 0.00037 20.5 2.5 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KPI85098.1 - 0.033 14.0 1.2 0.033 14.0 1.2 1.9 2 0 0 2 2 2 0 CCCH-type zinc finger Torus PF16131.5 KPI85098.1 - 0.041 14.6 0.3 0.08 13.6 0.3 1.4 1 0 0 1 1 1 0 Torus domain Sod_Fe_N PF00081.22 KPI85099.1 - 3.2e-08 33.9 0.1 5.2e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.18 KPI85099.1 - 1.3e-07 31.7 0.0 2.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain SHMT PF00464.19 KPI85102.1 - 6.9e-177 588.0 0.0 8.2e-177 587.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 KPI85102.1 - 0.00065 19.1 0.0 0.0019 17.5 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase REV1_C PF16727.5 KPI85102.1 - 0.063 13.7 0.1 0.26 11.7 0.0 2.0 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain STI1 PF17830.1 KPI85104.1 - 0.019 14.9 0.4 0.17 11.9 0.1 2.4 3 0 0 3 3 3 0 STI1 domain LEA_3 PF03242.13 KPI85104.1 - 0.068 13.9 0.1 0.2 12.4 0.1 1.7 1 0 0 1 1 1 0 Late embryogenesis abundant protein CactinC_cactus PF09732.9 KPI85105.1 - 5.6e-38 129.7 1.1 9.6e-38 128.9 1.1 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DUF2815 PF10991.8 KPI85105.1 - 0.12 12.4 0.1 0.59 10.1 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2815) DUF1388 PF07142.12 KPI85106.1 - 1 9.4 6.7 0.75 9.8 0.4 3.2 2 0 0 2 2 2 0 Repeat of unknown function (DUF1388) PCI PF01399.27 KPI85107.1 - 6.8e-10 39.4 0.4 1.6e-09 38.2 0.4 1.7 1 0 0 1 1 1 1 PCI domain eIF3_N PF09440.10 KPI85107.1 - 2.2e-08 34.6 4.6 3.2e-08 34.1 1.9 2.5 2 2 0 2 2 2 1 eIF3 subunit 6 N terminal domain OmpH PF03938.14 KPI85108.1 - 0.015 15.7 2.0 0.015 15.7 2.0 3.2 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) Glutaredoxin2_C PF04399.13 KPI85108.1 - 0.14 12.0 2.6 0.21 11.4 0.1 2.3 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Phe_tRNA-synt_N PF02912.18 KPI85108.1 - 3.2 7.8 7.3 0.52 10.3 2.1 2.4 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Hexapep PF00132.24 KPI85109.1 - 4e-06 26.3 15.7 0.0015 18.2 0.3 4.3 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KPI85109.1 - 0.0014 16.9 0.1 0.0021 16.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transferase PF00483.23 KPI85109.1 - 0.0059 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase DUF2616 PF11077.8 KPI85109.1 - 0.009 15.7 0.3 0.016 14.9 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2616) NTP_transf_3 PF12804.7 KPI85109.1 - 0.016 15.5 0.3 0.052 13.9 0.2 1.9 2 0 0 2 2 2 0 MobA-like NTP transferase domain Fucokinase PF07959.12 KPI85109.1 - 0.095 11.6 0.1 0.17 10.8 0.1 1.4 1 0 0 1 1 1 0 L-fucokinase SR-25 PF10500.9 KPI85109.1 - 1.5 8.4 8.5 1.4 8.4 1.4 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 KPI85109.1 - 1.9 9.2 14.5 1.4 9.6 3.9 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein Dehydrin PF00257.19 KPI85109.1 - 2.7 8.5 8.6 3.4 8.2 2.3 2.4 2 0 0 2 2 2 0 Dehydrin Hexapep_2 PF14602.6 KPI85109.1 - 8.4 6.2 12.8 1.3 8.9 1.4 3.4 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase DNA_topoisoIV PF00521.20 KPI85110.1 - 1e-126 423.3 0.0 1.8e-126 422.5 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KPI85110.1 - 5.8e-42 143.0 0.1 1.9e-41 141.4 0.1 2.0 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 KPI85110.1 - 2.4e-18 66.2 0.2 6.7e-18 64.8 0.2 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 KPI85110.1 - 6.4e-09 36.3 0.0 1.6e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KPI85110.1 - 7.1e-05 23.0 0.0 0.00019 21.6 0.0 1.7 1 0 0 1 1 1 1 Toprim domain PBP1_TM PF14812.6 KPI85110.1 - 0.0021 18.4 5.1 0.0021 18.4 5.1 4.4 3 0 0 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Pap_E4 PF02711.14 KPI85110.1 - 2.4 9.2 22.6 1.2 10.1 6.2 3.9 3 0 0 3 3 3 0 E4 protein MOZ_SAS PF01853.18 KPI85111.1 - 4.1e-40 137.3 1.1 2.4e-22 79.4 0.2 3.6 4 0 0 4 4 4 3 MOZ/SAS family PEX11 PF05648.14 KPI85112.1 - 4.8e-21 75.2 0.3 7.8e-21 74.6 0.3 1.3 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PEX11 PF05648.14 KPI85113.1 - 1.3e-06 28.1 1.9 1.2e-05 24.9 1.9 2.0 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Cyclin_N PF00134.23 KPI85115.1 - 0.00025 20.8 0.1 0.00048 19.9 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain PhosphMutase PF10143.9 KPI85116.1 - 2.7e-43 147.8 0.0 5.8e-43 146.7 0.0 1.6 1 1 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 KPI85116.1 - 4.7e-15 55.6 0.0 1.3e-14 54.1 0.0 1.7 1 1 0 1 1 1 1 Metalloenzyme superfamily GGACT PF06094.12 KPI85116.1 - 4.8e-14 53.0 0.0 1.4e-13 51.5 0.0 1.8 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Rrn6 PF10214.9 KPI85117.1 - 0.21 10.0 11.8 0.23 9.9 11.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Eaf7 PF07904.13 KPI85117.1 - 0.37 11.2 6.5 0.47 10.9 6.5 1.3 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 DNA_pol_alpha_N PF12254.8 KPI85117.1 - 0.37 10.9 15.5 0.69 10.0 15.1 1.7 1 1 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal PIN_2 PF10130.9 KPI85117.1 - 0.57 10.4 4.0 0.7 10.1 4.0 1.3 1 0 0 1 1 1 0 PIN domain DUF5486 PF17588.2 KPI85117.1 - 8.9 6.3 11.6 0.32 10.9 5.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5486) TP6A_N PF04406.14 KPI85119.1 - 4.8e-09 36.1 0.9 1.6e-08 34.4 0.9 2.0 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.10 KPI85119.1 - 0.019 14.9 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) RRM_1 PF00076.22 KPI85120.1 - 4.3e-12 45.7 0.0 7.5e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 KPI85120.1 - 2.3e-09 37.7 0.0 0.00052 20.3 0.0 2.4 2 0 0 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-rbx1 PF12678.7 KPI85121.1 - 2e-16 60.0 14.9 2e-16 60.0 14.9 1.4 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KPI85121.1 - 7.5e-16 58.0 7.7 8.6e-16 57.8 7.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KPI85121.1 - 3.5e-08 33.6 17.8 4.6e-07 30.1 17.8 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI85121.1 - 3.3e-06 26.9 14.1 2.1e-05 24.3 11.2 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI85121.1 - 0.00015 21.6 8.8 0.00015 21.6 8.8 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KPI85121.1 - 0.00016 21.5 8.5 0.00016 21.5 8.5 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI85121.1 - 0.00086 19.2 10.3 0.00086 19.2 10.3 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KPI85121.1 - 0.023 14.7 11.2 0.094 12.8 9.2 2.4 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 KPI85121.1 - 0.026 14.4 13.7 0.13 12.1 13.8 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KPI85121.1 - 0.4 10.6 6.9 0.23 11.3 5.3 1.5 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 KPI85121.1 - 0.61 9.9 12.5 13 5.6 12.5 2.4 1 1 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 KPI85121.1 - 1 9.0 17.8 0.06 13.0 11.0 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type DUF1272 PF06906.11 KPI85121.1 - 1.7 8.8 10.7 1.4e+02 2.7 10.7 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) zf-C3H2C3 PF17122.5 KPI85121.1 - 3.4 7.8 15.7 18 5.5 13.3 2.4 1 1 1 2 2 2 0 Zinc-finger zf-RING_4 PF14570.6 KPI85121.1 - 4.1 7.3 13.2 12 5.8 13.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 KPI85121.1 - 7.5 6.8 16.4 9.1e+02 0.1 16.4 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain DASH_Dad4 PF08650.10 KPI85122.1 - 0.17 11.9 9.3 0.57 10.2 0.0 4.6 3 1 1 4 4 4 0 DASH complex subunit Dad4 DUF2716 PF10898.8 KPI85122.1 - 5.2 7.4 6.9 5.1 7.5 0.7 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2716) DUF1738 PF08401.11 KPI85123.1 - 0.00037 20.6 0.0 0.25 11.4 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1738) Exo_endo_phos PF03372.23 KPI85124.1 - 2.2e-15 56.8 0.1 1.1e-14 54.5 0.1 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family eIF2A PF08662.11 KPI85125.1 - 4e-38 131.3 0.0 4.3e-35 121.4 0.0 3.0 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 KPI85125.1 - 0.015 16.1 0.1 16 6.5 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat LysM PF01476.20 KPI85126.1 - 1.4e-05 25.1 0.0 0.25 11.4 0.0 2.6 2 0 0 2 2 2 2 LysM domain LRR_6 PF13516.6 KPI85128.1 - 4.6e-09 35.6 13.7 0.96 9.7 0.1 6.4 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.7 KPI85128.1 - 4.8e-06 26.8 7.8 0.00037 20.8 0.0 4.2 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85128.1 - 0.00011 21.9 1.4 6.8 6.5 0.0 4.7 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 KPI85128.1 - 0.0028 18.0 6.1 21 6.2 0.0 5.3 4 1 0 4 4 4 1 Leucine Rich Repeat UCH PF00443.29 KPI85129.1 - 1.8e-35 122.7 0.0 3.8e-35 121.6 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI85129.1 - 6.4e-17 62.1 0.0 1.1e-15 58.1 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase baeRF_family11 PF18855.1 KPI85130.1 - 0.064 13.6 0.4 0.24 11.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 TAL_FSA PF00923.19 KPI85132.1 - 1.9e-95 319.5 0.4 2.1e-95 319.4 0.4 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Smr PF01713.21 KPI85133.1 - 6.6 7.2 10.6 0.22 11.9 3.6 2.0 2 1 0 2 2 2 0 Smr domain HSP70 PF00012.20 KPI85134.1 - 2.8e-231 768.9 7.5 1.7e-230 766.3 4.3 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KPI85134.1 - 3.3e-18 65.6 0.2 9.5e-18 64.1 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 KPI85134.1 - 0.015 14.6 0.3 0.037 13.3 0.3 1.7 1 1 0 1 1 1 0 Hydantoinase/oxoprolinase HORMA PF02301.18 KPI85134.1 - 0.029 14.0 0.6 0.059 12.9 0.6 1.4 1 0 0 1 1 1 0 HORMA domain DDR PF08841.10 KPI85134.1 - 0.035 13.1 0.1 2.1 7.2 0.1 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Ribonuc_L-PSP PF01042.21 KPI85134.1 - 0.086 12.9 0.2 0.81 9.7 0.0 2.5 2 0 0 2 2 2 0 Endoribonuclease L-PSP BRCT PF00533.26 KPI85135.1 - 2.2e-06 27.9 0.0 0.014 15.8 0.0 3.8 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KPI85135.1 - 3e-06 27.1 0.0 0.25 11.3 0.0 4.0 4 0 0 4 4 4 2 twin BRCT domain MCM3AP_GANP PF16769.5 KPI85135.1 - 0.18 10.0 0.6 0.29 9.4 0.6 1.2 1 0 0 1 1 1 0 MCM3AP domain of GANP LRR_4 PF12799.7 KPI85136.1 - 1.6e-11 44.2 6.9 5.4e-05 23.5 2.2 4.2 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85136.1 - 2e-11 43.4 4.6 0.00015 21.5 3.4 4.1 3 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 KPI85136.1 - 2.5e-05 24.2 8.9 15 6.6 0.1 6.0 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 KPI85136.1 - 0.00018 21.1 0.3 0.0053 16.3 0.1 2.8 3 0 0 3 3 3 1 Leucine-rich repeat LRR_6 PF13516.6 KPI85136.1 - 0.004 17.1 9.6 0.96 9.7 0.7 4.3 4 0 0 4 4 4 2 Leucine Rich repeat Aldo_ket_red PF00248.21 KPI85137.1 - 1.6e-27 96.5 0.0 8.7e-27 94.1 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family DnaJ PF00226.31 KPI85138.1 - 3e-20 72.1 0.5 5.4e-20 71.3 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KPI85138.1 - 2.5e-06 27.1 0.0 5.1e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 X-domain of DnaJ-containing LapA_dom PF06305.11 KPI85141.1 - 0.056 13.3 0.7 0.056 13.3 0.7 2.3 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Spo7 PF03907.13 KPI85141.1 - 0.4 10.1 2.2 0.65 9.4 0.2 1.9 2 0 0 2 2 2 0 Spo7-like protein MFS_1 PF07690.16 KPI85142.1 - 6e-21 74.8 25.0 6e-21 74.8 25.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KPI85142.1 - 4.7e-07 29.0 6.1 4.7e-07 29.0 6.1 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter WD40 PF00400.32 KPI85144.1 - 1e-18 67.3 14.4 3.7e-07 30.7 0.1 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85144.1 - 2.3e-05 24.6 0.1 0.0076 16.5 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI85144.1 - 0.0005 18.9 0.4 0.86 8.2 0.2 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 KPI85144.1 - 0.004 16.5 0.1 0.23 10.8 0.0 2.3 2 0 0 2 2 2 1 WD40-like domain Con-6 PF10346.9 KPI85144.1 - 0.054 13.5 0.7 4.1 7.5 0.1 2.4 2 0 0 2 2 2 0 Conidiation protein 6 SNARE PF05739.19 KPI85146.1 - 1.7e-07 31.1 1.2 4e-07 29.9 1.2 1.7 1 0 0 1 1 1 1 SNARE domain UPF0242 PF06785.11 KPI85146.1 - 0.00091 19.4 2.4 0.1 12.7 0.5 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 KPI85146.1 - 0.019 15.5 3.1 0.063 13.8 0.3 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal End3 PF12761.7 KPI85146.1 - 0.023 14.9 4.1 0.13 12.5 0.9 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Herpes_BBRF1 PF04793.12 KPI85146.1 - 0.033 13.2 1.0 0.21 10.6 0.2 2.0 2 0 0 2 2 2 0 BRRF1-like protein Spc7 PF08317.11 KPI85146.1 - 0.082 11.8 5.5 1.8 7.4 0.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Syntaxin PF00804.25 KPI85146.1 - 0.2 11.3 7.7 2.1 8.0 0.1 3.0 2 1 1 3 3 3 0 Syntaxin DUF724 PF05266.14 KPI85146.1 - 0.41 10.5 3.2 0.86 9.4 0.6 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF724) DUF948 PF06103.11 KPI85146.1 - 0.49 10.7 4.3 1.9 8.8 0.2 2.8 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TBCA PF02970.16 KPI85146.1 - 0.55 10.6 5.6 0.2 12.0 0.6 2.6 2 1 0 3 3 3 0 Tubulin binding cofactor A DUF1664 PF07889.12 KPI85146.1 - 0.82 9.7 6.7 5 7.2 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1635 PF07795.11 KPI85146.1 - 4.2 7.2 6.2 17 5.2 1.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1635) ALIX_LYPXL_bnd PF13949.6 KPI85147.1 - 3.4e-05 23.3 0.2 4.7e-05 22.8 0.2 1.3 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV CENP-F_N PF10481.9 KPI85147.1 - 0.0002 21.1 0.4 0.00039 20.2 0.4 1.5 1 0 0 1 1 1 1 Cenp-F N-terminal domain TPR_MLP1_2 PF07926.12 KPI85147.1 - 0.0093 16.0 4.2 0.52 10.4 0.0 2.6 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein HEPN_Cthe2314 PF18730.1 KPI85147.1 - 0.013 15.6 2.1 0.017 15.2 0.9 1.7 2 0 0 2 2 2 0 Cthe_2314-like HEPN OmpH PF03938.14 KPI85147.1 - 0.036 14.4 1.2 0.036 14.4 1.2 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF812 PF05667.11 KPI85147.1 - 0.092 11.6 5.1 0.53 9.1 5.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF812) TMPIT PF07851.13 KPI85147.1 - 0.12 11.6 1.3 0.8 8.9 0.9 2.0 2 0 0 2 2 2 0 TMPIT-like protein GreA_GreB_N PF03449.15 KPI85147.1 - 0.47 10.7 4.8 1.5 9.1 0.1 2.6 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Snf7 PF03357.21 KPI85148.1 - 0.011 15.3 1.9 0.011 15.3 1.9 2.6 1 1 0 2 2 2 0 Snf7 OmpH PF03938.14 KPI85148.1 - 0.036 14.4 13.5 0.062 13.6 7.5 2.7 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) Phage_TAC_8 PF10666.9 KPI85148.1 - 0.051 13.8 11.4 0.085 13.1 5.5 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Gp14 ()A118 DUF1216 PF06746.11 KPI85148.1 - 0.11 12.5 7.1 1.1 9.3 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1216) DUF1664 PF07889.12 KPI85148.1 - 0.27 11.3 4.8 1.7 8.7 0.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF3416 PF11896.8 KPI85148.1 - 0.46 10.7 3.4 0.77 10.0 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3416) RasGAP_C PF03836.15 KPI85148.1 - 0.75 9.9 12.5 0.7 10.0 10.3 1.9 1 1 1 2 2 2 0 RasGAP C-terminus AlphaC_C PF17480.2 KPI85148.1 - 0.76 9.8 5.0 1.6 8.8 0.0 2.5 1 1 1 2 2 2 0 AlphaC C-terminal Syntaxin_2 PF14523.6 KPI85148.1 - 1.3 9.5 9.2 11 6.5 8.4 2.6 1 1 1 2 2 2 0 Syntaxin-like protein TMPIT PF07851.13 KPI85148.1 - 2.1 7.5 12.9 1.1 8.4 6.3 2.0 1 1 1 2 2 2 0 TMPIT-like protein DUF4407 PF14362.6 KPI85148.1 - 2.8 7.2 6.0 3.1 7.1 5.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Methyltransf_23 PF13489.6 KPI85150.1 - 2.9e-13 50.0 0.0 5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI85150.1 - 2.9e-12 47.2 0.1 1.6e-11 44.8 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI85150.1 - 3.1e-11 43.3 0.4 6.2e-05 22.8 0.0 2.4 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 KPI85150.1 - 1.2e-09 38.7 0.1 1.1e-05 26.1 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 KPI85150.1 - 3.2e-09 37.3 0.2 3.5e-07 30.8 0.2 2.6 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 KPI85150.1 - 0.19 11.3 0.3 0.44 10.1 0.1 1.6 2 0 0 2 2 2 0 Nodulation protein S (NodS) Pkinase PF00069.25 KPI85151.1 - 9.2e-60 202.2 0.0 1.3e-59 201.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85151.1 - 1e-42 146.3 0.0 1.5e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI85151.1 - 0.0036 17.3 0.0 0.028 14.3 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI85151.1 - 0.0047 15.8 0.0 0.032 13.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 KPI85151.1 - 0.016 14.8 0.0 0.18 11.4 0.0 2.4 2 1 0 3 3 3 0 RIO1 family Haspin_kinase PF12330.8 KPI85151.1 - 0.099 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KPI85151.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like GHMP_kinases_C PF08544.13 KPI85152.1 - 1.3 9.5 5.8 0.7 10.3 0.2 3.1 2 0 0 2 2 2 0 GHMP kinases C terminal EF-G-binding_N PF07299.11 KPI85153.1 - 0.091 13.3 0.1 0.9 10.1 0.1 2.1 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal Mo25 PF08569.11 KPI85155.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Mo25-like Phage_holin_3_1 PF05106.12 KPI85155.1 - 0.11 12.9 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 Phage holin family (Lysis protein S) Cupin_8 PF13621.6 KPI85156.1 - 1.3e-17 64.4 0.1 1.6e-16 60.8 0.1 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KPI85156.1 - 1.8e-10 41.3 0.0 4.4e-10 40.0 0.0 1.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 KPI85156.1 - 9.9e-05 21.9 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein F-box PF00646.33 KPI85156.1 - 0.00094 19.0 0.7 0.0035 17.2 0.5 2.0 2 0 0 2 2 2 1 F-box domain Cupin_2 PF07883.11 KPI85156.1 - 0.0065 16.2 0.0 0.024 14.3 0.0 1.9 2 0 0 2 2 2 1 Cupin domain F-box-like PF12937.7 KPI85156.1 - 0.015 15.2 0.6 0.034 14.0 0.6 1.5 1 0 0 1 1 1 0 F-box-like Cupin_1 PF00190.22 KPI85156.1 - 0.2 11.3 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 Cupin tRNA-synt_1d PF00750.19 KPI85157.1 - 1.5e-108 362.9 0.2 3.6e-67 226.8 0.0 2.6 2 1 1 3 3 3 2 tRNA synthetases class I (R) DALR_1 PF05746.15 KPI85157.1 - 2.1e-27 95.7 0.5 8.5e-26 90.5 0.1 2.6 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KPI85157.1 - 6.5e-15 55.5 0.4 4.2e-14 52.9 0.3 2.3 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 KPI85157.1 - 0.066 12.6 0.0 0.21 10.9 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain zf-CCCH_4 PF18044.1 KPI85158.1 - 1.4e-08 34.3 7.0 2.9e-08 33.3 7.0 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger Helicase_C PF00271.31 KPI85158.1 - 1.4e-08 35.0 0.2 5.5e-08 33.1 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.29 KPI85158.1 - 1.6e-07 31.0 0.0 4.3e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 KH domain zf-CCCH PF00642.24 KPI85158.1 - 0.00034 20.4 5.1 0.00088 19.1 5.1 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI85158.1 - 0.015 15.3 8.1 0.034 14.2 8.1 1.7 1 0 0 1 1 1 0 Zinc finger domain Torus PF16131.5 KPI85158.1 - 0.034 14.8 0.7 0.12 13.1 0.7 1.9 1 0 0 1 1 1 0 Torus domain GRP PF07172.11 KPI85158.1 - 1.7 9.4 14.9 4.4 8.0 14.9 1.7 1 0 0 1 1 1 0 Glycine rich protein family LRR_6 PF13516.6 KPI85160.1 - 2.7e-16 58.2 17.7 0.0004 20.2 0.0 9.1 10 0 0 10 10 10 6 Leucine Rich repeat LRR_1 PF00560.33 KPI85160.1 - 1.2e-06 28.3 3.2 1.7 9.5 0.8 6.5 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_8 PF13855.6 KPI85160.1 - 5.1e-06 26.1 3.5 0.0045 16.7 1.5 5.3 3 2 1 4 4 4 1 Leucine rich repeat LRR_4 PF12799.7 KPI85160.1 - 6.4e-05 23.2 7.1 0.0042 17.5 0.1 4.8 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI85160.1 - 0.0044 16.5 0.0 0.013 15.0 0.0 1.8 1 0 0 1 1 1 1 Leucine-rich repeat Ribonucleas_3_3 PF14622.6 KPI85161.1 - 0.00037 20.7 0.0 0.0089 16.2 0.0 2.5 1 1 0 1 1 1 1 Ribonuclease-III-like UCH PF00443.29 KPI85163.1 - 5.2e-45 154.0 0.2 8.1e-45 153.3 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI85163.1 - 2.5e-09 37.2 3.0 5.8e-08 32.7 3.1 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DZR PF12773.7 KPI85163.1 - 0.096 12.7 3.7 1.4 9.0 0.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon CpXC PF14353.6 KPI85163.1 - 0.13 12.3 0.7 2.6 8.1 0.1 2.6 2 0 0 2 2 2 0 CpXC protein PhnA_Zn_Ribbon PF08274.12 KPI85163.1 - 0.15 12.0 6.0 5 7.2 1.6 2.6 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Zn-ribbon_8 PF09723.10 KPI85163.1 - 0.19 11.9 2.9 6 7.1 0.2 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-ACC PF17848.1 KPI85163.1 - 0.44 10.7 2.1 21 5.3 0.1 2.6 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-CHY PF05495.12 KPI85163.1 - 0.45 11.0 5.8 4.5 7.8 0.5 2.8 1 1 1 2 2 2 0 CHY zinc finger zinc-ribbons_6 PF07191.12 KPI85163.1 - 0.89 9.6 4.7 7.5 6.6 0.9 2.6 2 0 0 2 2 2 0 zinc-ribbons Sgf11 PF08209.11 KPI85163.1 - 1.1 8.9 3.7 12 5.6 0.2 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Prok-RING_4 PF14447.6 KPI85163.1 - 2.1 8.3 5.9 2.3 8.2 0.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Cation_efflux PF01545.21 KPI85164.1 - 2.2e-45 154.9 12.3 2.2e-45 154.9 12.3 2.7 2 0 0 2 2 2 1 Cation efflux family SpoVAB PF13782.6 KPI85164.1 - 0.66 10.3 8.5 0.22 11.8 3.5 2.7 2 0 0 2 2 2 0 Stage V sporulation protein AB Cpn60_TCP1 PF00118.24 KPI85165.1 - 3.9e-146 487.5 10.0 4.5e-146 487.3 10.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 KPI85166.1 - 2.5e-16 59.8 15.3 0.00011 22.9 0.2 5.7 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85166.1 - 3.2e-05 24.1 0.1 0.16 12.3 0.0 3.8 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M32 PF02074.15 KPI85167.1 - 3.5e-10 39.3 0.0 4.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase DUF641 PF04859.12 KPI85168.1 - 0.023 15.0 0.8 0.072 13.4 0.3 2.1 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) Syntaxin PF00804.25 KPI85168.1 - 0.063 12.9 0.3 0.11 12.1 0.3 1.3 1 0 0 1 1 1 0 Syntaxin Fez1 PF06818.15 KPI85168.1 - 0.14 12.6 0.6 0.41 11.1 0.2 1.8 2 0 0 2 2 2 0 Fez1 Pkinase PF00069.25 KPI85169.1 - 2.7e-51 174.5 0.0 4.1e-51 173.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85169.1 - 1.6e-20 73.5 0.0 2.3e-20 73.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI85169.1 - 0.013 15.5 0.0 0.1 12.5 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 KPI85169.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family EMP24_GP25L PF01105.24 KPI85170.1 - 5.3e-41 140.6 0.2 6.1e-41 140.4 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MogR_DNAbind PF12181.8 KPI85170.1 - 0.033 14.1 0.4 0.045 13.7 0.4 1.2 1 0 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) Lysine_decarbox PF03641.14 KPI85172.1 - 0.027 14.6 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 Possible lysine decarboxylase Ebp2 PF05890.12 KPI85173.1 - 3.2e-41 141.7 13.6 3.2e-41 141.7 13.6 1.9 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Vfa1 PF08432.10 KPI85173.1 - 6.8 7.0 18.5 8.3 6.7 2.6 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 KPI85173.1 - 7.1 4.6 17.9 11 4.0 17.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi GAS PF13851.6 KPI85174.1 - 2.2e-58 196.9 28.3 2.2e-58 196.9 28.3 3.0 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding HxlR PF01638.17 KPI85174.1 - 0.02 14.7 0.8 0.02 14.7 0.8 2.7 3 0 0 3 3 3 0 HxlR-like helix-turn-helix DUF948 PF06103.11 KPI85174.1 - 0.38 11.0 15.1 4 7.8 0.6 4.8 1 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) DTW PF03942.15 KPI85175.1 - 1.8e-22 80.1 0.2 2.9e-22 79.3 0.2 1.4 1 0 0 1 1 1 1 DTW domain zf-4CXXC_R1 PF10497.9 KPI85175.1 - 0.076 13.3 2.5 0.14 12.4 2.5 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DNA_pol_E_B PF04042.16 KPI85176.1 - 8.1e-24 84.1 0.0 1.2e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 KPI85176.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 DNA polymerases epsilon N terminal NEMP PF10225.9 KPI85177.1 - 0.055 13.1 0.0 0.076 12.7 0.0 1.1 1 0 0 1 1 1 0 NEMP family BRE1 PF08647.11 KPI85177.1 - 1.2 9.3 9.6 1.5 8.9 1.0 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 KPI85177.1 - 3.5 8.3 7.8 1.2 9.8 1.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA RPN13_C PF16550.5 KPI85178.1 - 2e-13 50.5 0.4 3.4e-13 49.7 0.2 1.5 1 1 0 1 1 1 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 KPI85178.1 - 4.7e-12 46.3 0.0 7.2e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Glutaredoxin2_C PF04399.13 KPI85178.1 - 0.11 12.3 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain DUF969 PF06149.12 KPI85179.1 - 0.016 14.6 0.0 0.021 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF969) Robl_LC7 PF03259.17 KPI85181.1 - 1.4e-21 76.0 0.0 1.6e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 KPI85181.1 - 2.4e-07 30.6 0.0 2.8e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Ras PF00071.22 KPI85181.1 - 0.011 15.4 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 0 Ras family CRM1_repeat_2 PF18784.1 KPI85181.1 - 0.038 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CRM1 / Exportin repeat 2 UCH PF00443.29 KPI85182.1 - 2.2e-51 174.9 0.1 3.8e-51 174.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI85182.1 - 2e-18 67.0 0.0 1.3e-16 61.1 0.0 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 KPI85182.1 - 2.1e-11 43.9 0.0 9.2e-11 41.8 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 KPI85182.1 - 9.4e-11 41.5 0.1 3.7e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 Pkinase PF00069.25 KPI85183.1 - 2.2e-57 194.4 0.0 2.6e-57 194.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85183.1 - 3e-18 66.1 0.0 4.1e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI85183.1 - 1.7e-07 31.4 0.0 0.00067 19.7 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI85183.1 - 0.015 14.7 0.0 0.058 12.7 0.0 1.9 2 0 0 2 2 2 0 Kinase-like ABC1 PF03109.16 KPI85183.1 - 0.15 12.3 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 ABC1 family Pro_isomerase PF00160.21 KPI85184.1 - 1e-08 35.6 0.0 1.8e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RTC PF01137.21 KPI85185.1 - 2.6e-41 141.2 0.1 3e-41 141.1 0.1 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 KPI85185.1 - 6.2e-26 90.9 0.1 9.3e-26 90.3 0.1 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain LRR_8 PF13855.6 KPI85186.1 - 1.1e-09 37.9 23.1 2.5e-06 27.2 2.9 4.1 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KPI85186.1 - 2.3e-09 37.4 19.4 0.0004 20.7 0.5 4.6 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI85186.1 - 9.3e-07 28.4 15.3 0.56 10.4 0.0 7.1 7 0 0 7 7 7 2 Leucine Rich repeat LRR_9 PF14580.6 KPI85186.1 - 0.00017 21.2 2.2 0.0069 15.9 0.1 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KPI85186.1 - 0.00068 19.8 21.9 12 6.9 2.6 7.6 4 3 1 5 5 5 2 Leucine Rich Repeat LRR_3 PF07725.12 KPI85186.1 - 1.4 8.9 10.4 3.4 7.7 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich Repeat GIT_CC PF16559.5 KPI85186.1 - 8.1 6.4 8.3 7.2 6.6 0.3 3.3 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TPR_2 PF07719.17 KPI85188.1 - 0.0033 17.4 0.5 4.4 7.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85188.1 - 0.0048 17.4 2.4 1.2 9.7 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 KPI85188.1 - 0.0053 17.1 1.7 0.18 12.1 0.0 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI85188.1 - 0.066 13.1 0.0 4.8 7.2 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85188.1 - 0.13 12.5 0.5 10 6.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Med11 PF10280.9 KPI85188.1 - 0.91 10.0 5.0 37 4.8 3.5 3.0 2 1 0 2 2 2 0 Mediator complex protein Meckelin PF09773.9 KPI85189.1 - 7.2e-219 729.0 0.8 7.2e-219 729.0 0.8 2.0 1 1 0 2 2 2 1 Meckelin (Transmembrane protein 67) hEGF PF12661.7 KPI85189.1 - 0.061 14.0 2.3 50 4.7 0.0 3.9 3 0 0 3 3 3 0 Human growth factor-like EGF TGT PF01702.18 KPI85190.1 - 1.1e-25 90.5 0.1 4.8e-19 68.7 0.6 2.0 2 0 0 2 2 2 2 Queuine tRNA-ribosyltransferase Peptidase_M48_N PF16491.5 KPI85191.1 - 2.9e-42 144.6 1.6 5.4e-42 143.7 1.6 1.4 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 KPI85191.1 - 4.3e-41 140.9 0.0 6.7e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 DEAD PF00270.29 KPI85192.1 - 2.4e-39 134.9 0.2 3.8e-39 134.3 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI85192.1 - 1.3e-22 80.2 0.0 1.8e-20 73.3 0.0 3.4 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI85192.1 - 3.4e-08 33.7 0.0 9e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4217 PF13959.6 KPI85192.1 - 1.3e-07 31.7 0.5 9.3e-07 29.0 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) DUF2914 PF11141.8 KPI85193.1 - 0.13 12.0 0.0 7.5 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) LVIVD PF08309.11 KPI85194.1 - 0.13 11.6 0.0 0.32 10.3 0.0 1.6 1 0 0 1 1 1 0 LVIVD repeat p450 PF00067.22 KPI85195.1 - 2e-56 191.7 0.0 2.8e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3017 PF11222.8 KPI85195.1 - 0.53 10.6 2.9 2.8 8.2 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3017) Pkinase PF00069.25 KPI85196.1 - 4.3e-69 232.8 0.0 5.7e-69 232.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85196.1 - 2.7e-30 105.5 0.0 1.4e-29 103.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI85196.1 - 0.051 12.9 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RINGv PF12906.7 KPI85198.1 - 1.4e-09 37.9 10.2 1.4e-09 37.9 10.2 1.7 2 0 0 2 2 2 1 RING-variant domain Rod_cone_degen PF15201.6 KPI85198.1 - 0.096 12.8 0.0 0.36 11.0 0.0 2.0 1 0 0 1 1 1 0 Progressive rod-cone degeneration Glyco_hydro_100 PF12899.7 KPI85198.1 - 0.21 10.2 0.0 0.31 9.7 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase ORMDL PF04061.14 KPI85198.1 - 0.52 10.1 2.1 2.2 8.1 0.2 2.3 2 0 0 2 2 2 0 ORMDL family WW PF00397.26 KPI85199.1 - 1.1e-11 44.5 2.3 1.1e-11 44.5 2.3 1.7 2 0 0 2 2 2 1 WW domain zf_CCCH_4 PF18345.1 KPI85199.1 - 1.7e-06 27.9 3.6 3.2e-06 27.0 3.6 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 KPI85199.1 - 2.2e-06 27.4 0.7 3.6e-06 26.7 0.7 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KPI85199.1 - 1.8e-05 24.4 1.6 3.5e-05 23.5 1.6 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 KPI85199.1 - 0.012 16.4 0.1 0.014 16.1 0.1 1.3 1 0 0 1 1 1 0 Torus domain Torus PF16131.5 KPI85202.1 - 6.7e-07 30.0 0.0 1.3e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 KPI85202.1 - 8.5e-07 28.8 2.6 1.3e-06 28.2 2.6 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KPI85202.1 - 2.7e-06 27.0 1.2 4e-06 26.5 1.2 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 KPI85202.1 - 0.0018 18.1 0.3 0.0029 17.5 0.3 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KPI85202.1 - 0.0037 17.7 2.3 0.0059 17.0 2.3 1.3 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger SET PF00856.28 KPI85203.1 - 4.2e-14 53.3 0.1 4.1e-13 50.1 0.1 2.0 1 1 0 1 1 1 1 SET domain OSTMP1 PF09777.9 KPI85203.1 - 0.0064 15.9 0.2 0.0097 15.3 0.2 1.2 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor Proteasome PF00227.26 KPI85206.1 - 1.8e-44 151.5 0.0 2.4e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI85206.1 - 1.2e-08 34.5 0.1 1.2e-08 34.5 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Lactamase_B_3 PF13483.6 KPI85206.1 - 0.019 14.9 0.0 0.068 13.1 0.0 1.8 2 0 0 2 2 2 0 Beta-lactamase superfamily domain PQQ_3 PF13570.6 KPI85206.1 - 0.41 11.2 1.7 18 6.0 0.4 2.9 2 1 0 2 2 2 0 PQQ-like domain Torus PF16131.5 KPI85207.1 - 0.0073 17.0 0.2 0.0073 17.0 0.2 1.7 2 0 0 2 2 2 1 Torus domain Inhibitor_I36 PF03995.13 KPI85207.1 - 0.032 14.2 0.8 0.33 10.9 0.0 2.8 3 0 0 3 3 3 0 Peptidase inhibitor family I36 zf-CCCH PF00642.24 KPI85207.1 - 3.9 7.5 6.0 5.6 7.0 1.5 2.3 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) VIT1 PF01988.19 KPI85208.1 - 4.3e-51 173.8 5.1 5.5e-51 173.5 5.1 1.1 1 0 0 1 1 1 1 VIT family SET PF00856.28 KPI85209.1 - 0.029 14.7 0.1 0.042 14.2 0.1 1.4 1 1 0 1 1 1 0 SET domain ADH_zinc_N PF00107.26 KPI85212.1 - 1.3e-20 73.7 0.3 2.6e-20 72.7 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KPI85212.1 - 5.5e-20 72.8 0.3 1.3e-19 71.5 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI85212.1 - 1.2e-07 31.6 0.0 3.1e-07 30.2 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KPI85213.1 - 1.2e-07 32.9 0.2 1.3e-07 32.7 0.2 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Cupin_1 PF00190.22 KPI85215.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Cupin AAA PF00004.29 KPI85216.1 - 3.6e-45 153.6 0.0 6.6e-45 152.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI85216.1 - 1.8e-12 46.9 0.1 3.9e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 KPI85216.1 - 1.2e-07 32.0 0.0 3e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KPI85216.1 - 1.4e-07 32.0 0.0 0.00023 21.6 0.0 2.4 1 1 0 2 2 2 2 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 KPI85216.1 - 2.1e-07 30.8 0.4 4.2e-07 29.8 0.4 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 KPI85216.1 - 5.7e-07 29.6 0.1 5.8e-06 26.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI85216.1 - 4.6e-06 26.5 0.0 1.2e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KPI85216.1 - 4.3e-05 23.8 0.1 0.022 15.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 KPI85216.1 - 0.00035 19.8 0.0 0.00069 18.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 KPI85216.1 - 0.00054 19.3 0.0 0.0012 18.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KPI85216.1 - 0.0015 18.3 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 KPI85216.1 - 0.0019 17.6 0.1 0.0037 16.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KPI85216.1 - 0.0019 18.6 0.0 0.0053 17.1 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 KPI85216.1 - 0.0019 17.9 0.0 0.0039 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KPI85216.1 - 0.0025 17.4 0.0 0.0071 15.9 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 KPI85216.1 - 0.0031 17.5 0.1 0.0076 16.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 KPI85216.1 - 0.0044 17.6 0.0 0.017 15.6 0.0 2.1 2 0 0 2 2 1 1 AAA domain Parvo_NS1 PF01057.17 KPI85216.1 - 0.0056 15.8 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 KPI85216.1 - 0.014 15.1 0.1 0.075 12.7 0.0 2.1 1 1 1 2 2 2 0 Sigma-54 interaction domain Prot_ATP_OB_N PF17758.1 KPI85216.1 - 0.014 15.0 0.0 0.039 13.6 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain ATPase PF06745.13 KPI85216.1 - 0.016 14.6 2.8 0.098 12.0 0.1 2.7 2 1 1 3 3 3 0 KaiC AAA_25 PF13481.6 KPI85216.1 - 0.016 14.8 0.3 0.13 11.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KPI85216.1 - 0.021 15.4 0.2 0.19 12.2 0.0 2.4 3 0 0 3 3 2 0 ABC transporter AAA_3 PF07726.11 KPI85216.1 - 0.022 14.6 0.0 0.051 13.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KPI85216.1 - 0.027 13.9 0.1 0.066 12.6 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein TsaE PF02367.17 KPI85216.1 - 0.028 14.4 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KPI85216.1 - 0.029 14.6 0.0 0.06 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KPI85216.1 - 0.037 13.9 1.1 1.1 9.1 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TRAF_BIRC3_bd PF16673.5 KPI85216.1 - 0.045 13.5 1.7 0.25 11.2 0.0 2.6 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain AAA_33 PF13671.6 KPI85216.1 - 0.048 13.8 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KPI85216.1 - 0.073 13.0 0.1 0.28 11.1 0.1 2.0 1 1 0 1 1 1 0 NACHT domain Bac_DnaA PF00308.18 KPI85216.1 - 0.077 12.8 0.4 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_30 PF13604.6 KPI85216.1 - 0.083 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KPI85216.1 - 0.1 12.4 0.2 0.8 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KPI85216.1 - 0.14 12.5 0.2 0.44 10.9 0.1 1.6 1 1 1 2 2 1 0 AAA domain TruD PF01142.18 KPI85217.1 - 7.3e-06 25.1 0.0 1.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) RRM_1 PF00076.22 KPI85218.1 - 1.4e-08 34.4 0.2 0.0073 16.1 0.0 5.0 5 1 0 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DSPc PF00782.20 KPI85219.1 - 0.037 13.8 0.4 0.085 12.7 0.4 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Tombus_P33 PF08500.10 KPI85219.1 - 0.12 12.3 0.1 0.36 10.8 0.1 1.7 1 0 0 1 1 1 0 Tombusvirus p33 BLI1 PF17324.2 KPI85219.1 - 0.18 12.5 0.0 0.85 10.3 0.1 1.9 2 0 0 2 2 2 0 BLOC-1 interactor 1 XkdW PF09636.10 KPI85219.1 - 0.29 11.3 1.1 0.69 10.0 1.1 1.6 1 0 0 1 1 1 0 XkdW protein Ank_2 PF12796.7 KPI85221.1 - 1.4e-31 108.9 0.0 1.8e-14 54.1 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI85221.1 - 1.9e-29 101.6 5.8 2.4e-09 37.5 0.1 5.3 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI85221.1 - 2.4e-27 94.7 3.3 2e-09 37.5 0.0 5.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI85221.1 - 5.4e-25 84.7 0.8 0.00019 21.6 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 KPI85221.1 - 7.6e-24 83.1 5.7 8.4e-06 26.0 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat DHHC PF01529.20 KPI85221.1 - 4.2e-06 26.9 0.4 4.2e-06 26.9 0.4 3.1 4 0 0 4 4 4 1 DHHC palmitoyltransferase Na_H_antiporter PF03553.14 KPI85224.1 - 0.14 11.4 0.0 0.15 11.2 0.0 1.0 1 0 0 1 1 1 0 Na+/H+ antiporter family zf-B_box PF00643.24 KPI85226.1 - 6.8e-08 32.5 2.7 1.5e-07 31.5 2.7 1.6 1 0 0 1 1 1 1 B-box zinc finger Macoilin PF09726.9 KPI85226.1 - 0.0091 14.6 0.0 0.016 13.8 0.0 1.4 1 0 0 1 1 1 1 Macoilin family OmpH PF03938.14 KPI85226.1 - 0.02 15.2 4.5 0.039 14.3 4.5 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 KPI85226.1 - 0.02 13.8 4.0 0.034 13.0 4.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_S46 PF10459.9 KPI85226.1 - 0.037 12.7 1.0 0.072 11.7 1.0 1.4 1 0 0 1 1 1 0 Peptidase S46 Exonuc_VII_L PF02601.15 KPI85226.1 - 0.038 13.6 1.6 0.2 11.2 1.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit TACC_C PF05010.14 KPI85226.1 - 0.069 12.9 3.7 0.035 13.9 1.4 1.6 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal IFT57 PF10498.9 KPI85226.1 - 0.095 11.7 2.0 0.15 11.0 2.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SlyX PF04102.12 KPI85226.1 - 0.12 13.0 10.9 2.4 8.8 7.1 2.9 1 1 1 2 2 2 0 SlyX DUF3450 PF11932.8 KPI85226.1 - 1 8.6 7.5 2.5 7.4 7.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TMPIT PF07851.13 KPI85226.1 - 1.2 8.3 3.3 1.9 7.6 3.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein Lipase_3 PF01764.25 KPI85227.1 - 4.8e-10 39.5 0.1 3.8e-09 36.6 0.1 2.3 3 0 0 3 3 3 1 Lipase (class 3) Hydrolase_4 PF12146.8 KPI85227.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Voltage_CLC PF00654.20 KPI85228.1 - 1.2e-83 281.3 25.6 7.9e-83 278.6 24.1 2.1 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KPI85228.1 - 9.1e-07 29.2 0.4 0.00041 20.7 0.0 2.6 2 0 0 2 2 2 2 CBS domain CAAD PF14159.6 KPI85228.1 - 0.099 12.5 0.1 0.48 10.3 0.0 2.2 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Romo1 PF10247.9 KPI85228.1 - 5.4 7.5 6.7 2.4 8.6 0.1 3.3 4 0 0 4 4 4 0 Reactive mitochondrial oxygen species modulator 1 TruD PF01142.18 KPI85229.1 - 7.2e-32 110.7 0.0 1.2e-28 100.1 0.0 3.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) zf-MYND PF01753.18 KPI85230.1 - 5.6e-05 23.2 10.5 5.6e-05 23.2 10.5 1.9 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.6 KPI85230.1 - 0.0013 18.8 8.4 0.0023 18.0 6.5 2.2 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-HIT PF04438.16 KPI85230.1 - 0.048 13.5 7.6 0.16 11.9 7.6 1.9 1 0 0 1 1 1 0 HIT zinc finger zf-C2H2_4 PF13894.6 KPI85230.1 - 6.2 7.9 8.3 21 6.3 8.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger Abhydrolase_1 PF00561.20 KPI85231.1 - 0.038 13.6 0.0 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Dopey_N PF04118.14 KPI85232.1 - 1.1e-36 126.5 0.0 1.1e-34 120.0 0.0 2.4 2 0 0 2 2 2 2 Dopey, N-terminal TMEM171 PF15471.6 KPI85233.1 - 1.1 8.1 7.3 1.1 8.1 0.0 3.2 3 0 0 3 3 3 0 Transmembrane protein family 171 UPF0564 PF10595.9 KPI85234.1 - 3e-10 39.7 34.2 9.2e-07 28.2 4.3 4.3 4 1 1 5 5 5 3 Uncharacterised protein family UPF0564 TA_inhibitor PF17574.2 KPI85235.1 - 0.18 11.9 0.4 0.63 10.1 0.4 1.9 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) MFS_1_like PF12832.7 KPI85237.1 - 7.7e-50 169.9 21.6 1.4e-49 169.0 21.6 1.3 1 1 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 KPI85237.1 - 1e-19 70.7 55.5 2.3e-16 59.7 35.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 KPI85237.1 - 4.1e-07 29.3 23.5 5.8e-07 28.8 23.5 1.2 1 0 0 1 1 1 1 Nucleoside H+ symporter LacY_symp PF01306.19 KPI85237.1 - 0.00074 18.4 12.0 0.013 14.3 12.0 2.6 1 1 0 1 1 1 1 LacY proton/sugar symporter Dermcidin PF15291.6 KPI85237.1 - 0.4 11.2 6.3 2.4 8.7 1.8 2.4 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide Thioredoxin PF00085.20 KPI85238.1 - 5.2e-07 29.6 0.1 7.6e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Ribosomal_L29 PF00831.23 KPI85238.1 - 0.023 14.7 1.6 5.2 7.1 0.1 2.4 2 0 0 2 2 2 0 Ribosomal L29 protein Thioredoxin_8 PF13905.6 KPI85238.1 - 0.04 14.3 0.3 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like AhpC-TSA PF00578.21 KPI85238.1 - 0.061 13.2 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_2 PF13098.6 KPI85238.1 - 0.098 13.1 0.2 0.22 12.0 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin-like domain DASH_Hsk3 PF08227.11 KPI85241.1 - 0.008 16.5 0.4 0.25 11.8 0.3 2.4 2 0 0 2 2 2 1 DASH complex subunit Hsk3 like DUF2442 PF10387.9 KPI85241.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) WD40 PF00400.32 KPI85243.1 - 2.9e-08 34.2 11.5 8.4e-05 23.3 0.2 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85243.1 - 0.0018 18.5 0.0 22 5.4 0.0 4.4 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KPI85243.1 - 0.0035 17.8 0.3 21 5.8 0.0 4.8 3 1 0 3 3 3 1 PQQ-like domain DUF4407 PF14362.6 KPI85243.1 - 0.065 12.6 3.7 0.12 11.7 3.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FmiP_Thoc5 PF09766.9 KPI85243.1 - 0.097 11.9 1.3 0.17 11.1 1.3 1.3 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 GTP-bdg_M PF16360.5 KPI85243.1 - 1.9 9.1 7.9 18 6.0 2.7 2.5 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region Jnk-SapK_ap_N PF09744.9 KPI85243.1 - 7.2 6.8 6.7 2.7 8.2 2.3 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 WD40 PF00400.32 KPI85244.1 - 1.7e-09 38.1 17.0 7.7e-08 32.9 0.1 5.4 5 1 1 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85244.1 - 6.8e-06 26.3 0.3 0.56 10.5 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KPI85244.1 - 0.0013 18.3 0.7 0.015 14.9 0.5 2.6 1 1 0 1 1 1 1 PQQ-like domain ADIP PF11559.8 KPI85244.1 - 0.043 13.9 1.6 0.075 13.1 1.6 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4274 PF14096.6 KPI85244.1 - 0.068 13.1 0.1 0.2 11.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4274) BBS2_Mid PF14783.6 KPI85244.1 - 0.11 12.5 0.4 32 4.6 0.0 4.2 4 2 2 6 6 6 0 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.6 KPI85244.1 - 0.13 12.8 2.7 8.5 7.0 0.0 4.2 2 1 0 2 2 2 0 PQQ-like domain DUF4094 PF13334.6 KPI85244.1 - 0.26 11.7 0.6 0.53 10.7 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) WD40_like PF17005.5 KPI85244.1 - 0.29 10.4 0.0 5.7 6.2 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain UIM PF02809.20 KPI85245.1 - 0.00076 19.2 0.6 0.0015 18.3 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin interaction motif F-box PF00646.33 KPI85245.1 - 0.0076 16.1 0.0 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 F-box domain CDC45 PF02724.14 KPI85245.1 - 0.092 11.0 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 CDC45-like protein PPR_2 PF13041.6 KPI85246.1 - 3.5e-05 23.9 0.1 0.00035 20.7 0.1 2.4 3 0 0 3 3 3 1 PPR repeat family PPR PF01535.20 KPI85246.1 - 0.00069 19.7 0.1 5.7 7.4 0.0 3.6 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 KPI85246.1 - 0.021 14.9 0.0 0.055 13.6 0.0 1.7 1 0 0 1 1 1 0 Pentatricopeptide repeat domain AAA PF00004.29 KPI85247.1 - 1.7e-14 54.4 0.0 1.1e-09 38.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KPI85247.1 - 5.3e-07 29.7 0.0 1.4e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI85247.1 - 5.6e-05 23.6 0.0 0.00045 20.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KPI85247.1 - 0.0013 19.0 0.0 0.013 15.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KPI85247.1 - 0.003 17.3 0.0 0.0061 16.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KPI85247.1 - 0.0035 17.9 0.0 0.014 15.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 KPI85247.1 - 0.0075 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain BEN PF10523.9 KPI85247.1 - 0.0099 16.1 0.1 0.038 14.2 0.0 2.0 2 0 0 2 2 2 1 BEN domain AAA_25 PF13481.6 KPI85247.1 - 0.011 15.4 0.0 0.031 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KPI85247.1 - 0.015 15.0 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 KPI85247.1 - 0.015 14.5 0.0 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 KPI85247.1 - 0.026 13.8 0.1 0.1 11.9 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 KPI85247.1 - 0.027 14.6 0.0 0.07 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KPI85247.1 - 0.037 13.4 0.0 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 KPI85247.1 - 0.039 13.3 0.0 0.088 12.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KPI85247.1 - 0.045 13.4 0.0 0.087 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 KPI85247.1 - 0.05 13.8 0.0 0.19 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KPI85247.1 - 0.056 13.4 0.0 1 9.2 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Bac_DnaA PF00308.18 KPI85247.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein RNA_helicase PF00910.22 KPI85247.1 - 0.061 13.7 0.0 0.19 12.1 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ATPase_2 PF01637.18 KPI85247.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 KPI85247.1 - 0.094 13.1 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KPI85247.1 - 0.15 11.5 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 KPI85247.1 - 0.16 11.7 1.2 0.6 9.9 1.2 2.0 1 1 0 1 1 1 0 AAA domain IPT PF01745.16 KPI85247.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Isopentenyl transferase NB-ARC PF00931.22 KPI85247.1 - 0.18 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Ax_dynein_light PF10211.9 KPI85249.1 - 9.8e-41 139.8 9.8 1.5e-40 139.2 9.8 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain APG6_N PF17675.1 KPI85249.1 - 0.0087 16.6 10.5 0.017 15.6 10.5 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region Filament PF00038.21 KPI85249.1 - 0.34 10.4 14.6 0.53 9.8 14.6 1.2 1 0 0 1 1 1 0 Intermediate filament protein Molydop_binding PF01568.21 KPI85249.1 - 0.5 10.4 3.2 1.5 8.9 0.2 2.7 3 0 0 3 3 3 0 Molydopterin dinucleotide binding domain Spc24 PF08286.11 KPI85249.1 - 2.5 8.4 5.1 5.9 7.2 5.1 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 PUF PF00806.19 KPI85252.1 - 5e-50 164.4 5.1 1.9e-06 27.3 0.1 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CYYR1 PF10873.8 KPI85253.1 - 0.056 13.9 0.8 0.079 13.4 0.3 1.5 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Herpes_gE PF02480.16 KPI85253.1 - 0.066 12.0 0.0 0.07 11.9 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E WD40 PF00400.32 KPI85254.1 - 0.0033 18.2 6.6 1 10.3 0.7 4.9 4 0 0 4 4 4 1 WD domain, G-beta repeat SARS_X4 PF08779.10 KPI85254.1 - 0.08 13.2 0.2 3.2 8.0 0.1 2.7 2 0 0 2 2 2 0 SARS coronavirus X4 like LRR_9 PF14580.6 KPI85255.1 - 3.6e-11 42.9 0.7 9.1e-11 41.6 0.6 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KPI85255.1 - 2.9e-08 33.3 4.9 2.5e-05 23.9 0.5 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI85255.1 - 5.5e-07 29.8 3.5 0.00028 21.2 1.0 2.9 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI85255.1 - 6.9e-05 22.6 0.6 8 6.8 0.0 3.8 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.33 KPI85255.1 - 0.72 10.6 2.8 41 5.3 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat TRAPP PF04051.16 KPI85256.1 - 3e-24 85.4 0.0 3.5e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Mito_carr PF00153.27 KPI85257.1 - 1.7e-52 175.3 0.1 7.3e-21 73.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein 6PGD PF00393.19 KPI85258.1 - 4.1e-74 249.5 0.0 5.7e-74 249.1 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KPI85258.1 - 1.1e-44 152.4 0.0 1.8e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KPI85258.1 - 1.4e-05 25.1 0.1 4e-05 23.7 0.1 1.8 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 KPI85258.1 - 0.00015 22.3 0.1 0.00038 21.0 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 KPI85258.1 - 0.00019 21.4 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 KPI85258.1 - 0.00036 20.5 0.0 0.00077 19.5 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 KPI85258.1 - 0.012 15.0 0.1 0.02 14.2 0.1 1.4 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PGK PF00162.19 KPI85258.1 - 0.055 12.4 0.0 0.088 11.7 0.0 1.2 1 0 0 1 1 1 0 Phosphoglycerate kinase Git3 PF11710.8 KPI85258.1 - 0.21 11.3 0.6 0.35 10.6 0.0 1.6 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 TP_methylase PF00590.20 KPI85259.1 - 3.5e-22 79.4 2.4 3.5e-22 79.4 0.3 2.1 2 1 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF1455 PF07306.11 KPI85259.1 - 0.072 13.1 0.5 0.21 11.6 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) DUF2428 PF10350.9 KPI85260.1 - 1.3e-34 119.7 0.0 3.9e-34 118.2 0.0 1.9 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) DUF1484 PF07363.11 KPI85260.1 - 0.44 11.6 3.6 6.3 7.8 0.3 4.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1484) HEAT PF02985.22 KPI85260.1 - 0.48 10.8 7.1 42 4.8 0.8 6.0 5 0 0 5 5 5 0 HEAT repeat HA2 PF04408.23 KPI85261.1 - 0.12 12.6 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 Helicase associated domain (HA2) PARP_regulatory PF01358.18 KPI85262.1 - 2.7e-15 56.1 0.0 1.3e-09 37.5 0.0 2.6 2 1 0 2 2 2 2 Poly A polymerase regulatory subunit Coiled PF05710.12 KPI85263.1 - 0.058 14.2 0.7 0.1 13.5 0.7 1.4 1 0 0 1 1 1 0 Coiled coil Ribosomal_60s PF00428.19 KPI85263.1 - 2.6 8.7 5.7 1.8 9.2 3.0 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein CDC50 PF03381.15 KPI85264.1 - 4.4e-72 242.9 0.0 5.6e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF3185 PF11381.8 KPI85264.1 - 0.18 11.8 0.3 0.38 10.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) Nitr_red_bet_C PF14711.6 KPI85266.1 - 0.059 13.1 0.0 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Respiratory nitrate reductase beta C-terminal COX7a PF02238.15 KPI85267.1 - 0.11 12.9 0.3 0.23 11.9 0.3 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII Rep_fac-A_3 PF08661.11 KPI85268.1 - 2.3e-07 31.1 0.0 3.4e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Replication factor A protein 3 Rad4 PF03835.15 KPI85269.1 - 1.3e-18 67.1 0.2 2.8e-18 66.0 0.2 1.6 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 KPI85269.1 - 7.2e-14 51.9 0.0 2.4e-13 50.3 0.0 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 KPI85269.1 - 5.9e-12 45.2 0.0 1.2e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 KPI85269.1 - 0.021 15.2 1.4 4.8 7.7 0.1 3.7 3 1 0 3 3 3 0 Transglutaminase-like superfamily BHD_2 PF10404.9 KPI85269.1 - 0.024 15.6 7.1 0.029 15.3 0.1 3.4 3 1 0 3 3 3 0 Rad4 beta-hairpin domain 2 peroxidase PF00141.23 KPI85270.1 - 2.2e-09 37.4 0.0 2.8e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Acyl_transf_1 PF00698.21 KPI85271.1 - 1.8e-21 77.0 0.0 9.3e-21 74.6 0.1 2.2 2 1 0 2 2 2 1 Acyl transferase domain PDU_like PF15953.5 KPI85271.1 - 0.02 15.0 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative propanediol utilisation p450 PF00067.22 KPI85272.1 - 2.8e-62 211.0 0.0 3.5e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DHHC PF01529.20 KPI85273.1 - 6.5e-25 87.8 18.4 6.5e-25 87.8 18.4 2.3 2 1 1 3 3 3 1 DHHC palmitoyltransferase DUF368 PF04018.13 KPI85273.1 - 0.029 14.0 4.7 0.13 11.9 4.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF368) DUF2406 PF10295.9 KPI85273.1 - 0.15 12.7 0.3 1.3 9.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein (DUF2406) PocR PF10114.9 KPI85273.1 - 3.4 7.4 7.1 1.3 8.8 3.4 2.0 2 0 0 2 2 2 0 Sensory domain found in PocR DHHC PF01529.20 KPI85274.1 - 4.7e-27 94.7 16.0 4.7e-27 94.7 16.0 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase SecY PF00344.20 KPI85276.1 - 4.1e-63 213.5 8.0 5.1e-63 213.1 8.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KPI85276.1 - 4.5e-15 55.2 0.0 1.2e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p TMEM237 PF15383.6 KPI85276.1 - 0.0072 15.4 0.2 0.014 14.5 0.2 1.4 1 0 0 1 1 1 1 Transmembrane protein 237 RRM_1 PF00076.22 KPI85277.1 - 0.00017 21.3 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Suf PF05843.14 KPI85277.1 - 0.0078 16.2 12.8 0.0078 16.2 12.8 3.5 4 0 0 4 4 4 1 Suppressor of forked protein (Suf) SR-25 PF10500.9 KPI85277.1 - 0.0086 15.7 10.2 0.0086 15.7 10.2 2.1 2 0 0 2 2 1 1 Nuclear RNA-splicing-associated protein NARP1 PF12569.8 KPI85277.1 - 0.026 13.5 8.4 0.046 12.6 8.4 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DcuA_DcuB PF03605.14 KPI85277.1 - 0.21 10.4 0.2 0.34 9.8 0.2 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter FHIPEP PF00771.20 KPI85277.1 - 0.23 9.9 2.8 0.42 9.0 2.8 1.3 1 0 0 1 1 1 0 FHIPEP family EPL1 PF10513.9 KPI85277.1 - 0.53 10.7 17.5 0.21 11.9 8.4 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like Eapp_C PF10238.9 KPI85277.1 - 0.8 9.8 15.2 0.094 12.8 6.2 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein Folate_carrier PF01770.18 KPI85277.1 - 0.91 8.2 4.0 1.6 7.4 4.0 1.3 1 0 0 1 1 1 0 Reduced folate carrier SpoIIP PF07454.11 KPI85277.1 - 1.3 8.4 17.0 0.14 11.6 9.5 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 KPI85277.1 - 1.4 7.1 7.6 2.4 6.4 7.6 1.3 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 KPI85277.1 - 1.4 7.8 19.4 0.026 13.5 8.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) BSMAP PF12280.8 KPI85277.1 - 2.4 8.3 14.4 6.3 7.0 6.6 2.5 2 0 0 2 2 2 0 Brain specific membrane anchored protein CPSF100_C PF13299.6 KPI85277.1 - 3.3 7.9 14.3 0.32 11.2 7.5 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 KPI85277.1 - 4.1 6.1 19.3 0.32 9.7 9.9 2.2 2 0 0 2 2 2 0 Presenilin OATP PF03137.20 KPI85277.1 - 4.5 5.4 8.1 8.4 4.5 8.1 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Band_3_cyto PF07565.13 KPI85277.1 - 7.8 6.2 13.1 1.3 8.7 6.0 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF5616 PF18481.1 KPI85278.1 - 0.1 12.9 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5616) SAT PF16073.5 KPI85280.1 - 5.5e-06 26.3 2.6 1.9e-05 24.5 0.0 2.7 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis LSM PF01423.22 KPI85281.1 - 4.2e-06 26.4 0.1 3e-05 23.6 0.1 2.1 1 1 0 1 1 1 1 LSM domain zf-RING_UBOX PF13445.6 KPI85282.1 - 4.1e-08 33.1 8.2 4.1e-08 33.1 8.2 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KPI85282.1 - 5e-08 32.7 11.9 5e-08 32.7 11.9 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KPI85282.1 - 1.4e-07 31.3 14.1 1.4e-07 31.3 14.1 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI85282.1 - 2.5e-07 30.4 9.9 2.5e-07 30.4 9.9 3.0 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI85282.1 - 2.1e-06 27.8 12.3 2.1e-06 27.8 12.3 2.7 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KPI85282.1 - 0.0002 21.6 15.9 0.0002 21.6 15.9 3.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 KPI85282.1 - 0.001 19.0 10.5 0.001 19.0 10.5 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_10 PF16685.5 KPI85282.1 - 0.041 14.0 14.6 0.16 12.1 14.6 2.0 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.8 KPI85282.1 - 0.21 11.4 8.0 0.44 10.4 8.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 KPI85282.1 - 0.86 9.5 19.6 0.029 14.2 12.3 2.4 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Histone_H2A_C PF16211.5 KPI85283.1 - 4.7e-11 42.2 1.4 1.1e-10 41.0 1.4 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KPI85283.1 - 7.6e-10 39.3 0.0 1.1e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 2Fe-2S_thioredx PF01257.19 KPI85284.1 - 7.7e-48 162.0 0.0 1e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PALP PF00291.25 KPI85286.1 - 3.8e-65 220.2 0.0 4.6e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RCC1 PF00415.18 KPI85287.1 - 1.4e-52 176.1 38.2 5.1e-13 49.4 1.3 9.1 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI85287.1 - 5.7e-31 105.7 42.5 2.5e-12 46.3 2.5 8.9 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat BTB_2 PF02214.22 KPI85287.1 - 1.9e-07 31.3 0.0 0.013 15.8 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain DUF4213 PF13938.6 KPI85287.1 - 1.1 9.5 4.9 17 5.7 0.0 4.2 4 0 0 4 4 4 0 Putative heavy-metal chelation WD40 PF00400.32 KPI85288.1 - 2.4e-29 100.9 13.7 1.3e-07 32.1 0.2 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85288.1 - 8.6e-12 45.2 0.0 0.048 14.0 0.0 4.7 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI85288.1 - 3.3e-06 26.3 0.3 0.02 13.8 0.0 3.6 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KPI85288.1 - 7.6e-06 25.7 0.0 0.48 10.4 0.0 3.6 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 KPI85288.1 - 0.00098 19.0 0.0 0.059 13.3 0.0 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KPI85288.1 - 0.001 17.8 1.5 0.32 9.6 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Frtz PF11768.8 KPI85288.1 - 0.0026 16.2 0.0 0.03 12.7 0.0 2.0 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 KPI85288.1 - 0.016 13.7 0.0 1.2 7.6 0.0 2.5 1 1 2 3 3 3 0 Cytochrome D1 heme domain nos_propeller PF18764.1 KPI85288.1 - 0.033 14.1 0.2 3.4 7.6 0.0 3.6 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat PQQ PF01011.21 KPI85288.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 PQQ enzyme repeat Kinesin PF00225.23 KPI85289.1 - 4.6e-27 94.8 0.0 1.5e-26 93.2 0.0 1.8 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI85289.1 - 1.5e-05 25.0 0.0 5.1e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding dCMP_cyt_deam_2 PF08211.12 KPI85289.1 - 6.4 7.0 7.4 0.29 11.3 0.2 2.6 3 0 0 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region FAP206 PF12018.8 KPI85290.1 - 1.6e-07 31.2 0.1 2.5e-05 23.9 0.0 2.6 3 0 0 3 3 3 2 Domain of unknown function Peptidase_M20 PF01546.28 KPI85291.1 - 1.4e-11 44.5 0.1 2.2e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI85291.1 - 8e-07 29.0 0.0 2.7e-06 27.3 0.0 1.9 1 1 1 2 2 2 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 KPI85291.1 - 4.5e-06 25.9 0.1 0.00089 18.4 0.1 2.4 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 KPI85291.1 - 0.0018 18.0 0.0 0.0084 15.8 0.0 2.1 3 0 0 3 3 3 1 Peptidase family M28 Rcd1 PF04078.13 KPI85292.1 - 2.6e-99 331.7 0.6 3e-99 331.5 0.6 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like ADIP PF11559.8 KPI85293.1 - 0.021 14.9 5.2 0.024 14.7 5.2 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Wtap PF17098.5 KPI85293.1 - 0.034 14.1 3.5 0.042 13.8 3.5 1.2 1 0 0 1 1 1 0 WTAP/Mum2p family DUF724 PF05266.14 KPI85293.1 - 0.095 12.5 3.0 0.11 12.3 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ABC_tran_CTD PF16326.5 KPI85293.1 - 0.1 12.8 5.4 0.054 13.8 2.9 1.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain Spc7 PF08317.11 KPI85293.1 - 0.13 11.1 5.3 0.15 10.9 5.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein CorA PF01544.18 KPI85293.1 - 0.31 10.3 3.3 0.32 10.3 3.3 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein APG6_N PF17675.1 KPI85293.1 - 1.2 9.7 9.5 3.4 8.2 9.5 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region PI3_PI4_kinase PF00454.27 KPI85294.1 - 1.1e-57 195.8 0.0 2.5e-57 194.6 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 KPI85294.1 - 3.3e-38 131.8 0.7 3.3e-38 131.8 0.7 2.3 2 1 0 2 2 2 1 FAT domain FRB_dom PF08771.11 KPI85294.1 - 4.3e-28 97.6 2.1 6.6e-28 97.0 0.3 2.4 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain DUF3385 PF11865.8 KPI85294.1 - 1.7e-15 57.3 0.0 2.9e-14 53.3 0.0 3.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) FATC PF02260.20 KPI85294.1 - 2.9e-10 39.8 0.4 9.4e-10 38.1 0.4 1.9 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 KPI85294.1 - 0.0015 18.6 5.7 3.4 8.2 0.0 6.8 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 KPI85294.1 - 0.0018 18.6 0.0 2.3 8.7 0.0 4.7 4 0 0 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 KPI85294.1 - 0.0071 16.8 2.2 12 6.5 0.0 6.1 7 0 0 7 7 7 1 HEAT-like repeat Cnd1 PF12717.7 KPI85294.1 - 0.087 12.9 4.6 0.94 9.5 0.0 4.9 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Synaptobrevin PF00957.21 KPI85295.1 - 3.8e-08 33.0 4.7 7.4e-08 32.1 4.7 1.4 1 0 0 1 1 1 1 Synaptobrevin CSN8_PSD8_EIF3K PF10075.9 KPI85298.1 - 4.8e-16 59.0 0.3 9e-16 58.2 0.3 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 KPI85298.1 - 3.4e-05 24.3 0.3 6.4e-05 23.4 0.3 1.6 1 1 0 1 1 1 1 PCI domain FPL PF09758.9 KPI85298.1 - 0.029 14.4 0.1 0.052 13.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein GTP_EFTU PF00009.27 KPI85300.1 - 3.1e-25 88.8 0.0 5.7e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KPI85300.1 - 7.6e-16 57.9 0.0 1.5e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KPI85300.1 - 1.8e-08 34.3 0.0 5e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 KPI85300.1 - 1.1e-05 25.5 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_IV PF03764.18 KPI85300.1 - 1.1e-05 25.2 0.0 2.3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV Septin PF00735.18 KPI85300.1 - 0.0021 17.4 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Septin Roc PF08477.13 KPI85300.1 - 0.003 17.8 0.0 0.0057 16.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 KPI85300.1 - 0.021 14.2 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.23 KPI85300.1 - 0.027 14.5 0.1 4.3 7.4 0.0 2.3 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 KPI85300.1 - 0.038 13.4 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 KPI85300.1 - 0.12 12.1 0.0 0.78 9.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation EFTUD2 PF16004.5 KPI85300.1 - 2.1 9.0 7.9 32 5.1 7.9 2.2 1 1 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Complex1_LYR PF05347.15 KPI85301.1 - 8.4e-12 45.0 0.3 1.8e-11 43.9 0.3 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 KPI85301.1 - 0.0003 21.3 0.2 0.00068 20.2 0.2 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.6 KPI85301.1 - 0.3 11.9 4.8 6.8 7.5 4.8 2.3 1 1 0 1 1 1 0 Complex1_LYR-like APG6_N PF17675.1 KPI85302.1 - 0.014 15.9 1.6 0.014 15.9 1.6 18.2 3 2 13 16 16 16 0 Apg6 coiled-coil region DEAD PF00270.29 KPI85303.1 - 4.6e-39 134.0 0.0 1.3e-38 132.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI85303.1 - 6.2e-24 84.5 0.0 1.4e-23 83.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KPI85303.1 - 2.6e-14 53.2 0.3 6.7e-14 51.9 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KPI85303.1 - 0.014 15.4 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Bravo_FIGEY PF13882.6 KPI85303.1 - 0.19 13.1 2.1 0.69 11.3 0.0 2.9 3 0 0 3 3 3 0 Bravo-like intracellular region Formyl_trans_N PF00551.19 KPI85304.1 - 1.5e-17 63.9 0.0 3.2e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase TAF4 PF05236.14 KPI85304.1 - 3.7 7.2 6.2 7.1 6.3 0.0 2.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family CS PF04969.16 KPI85306.1 - 0.0058 17.6 0.3 0.012 16.6 0.3 1.6 1 0 0 1 1 1 1 CS domain AstB PF04996.12 KPI85307.1 - 0.59 8.7 2.8 0.31 9.6 0.4 1.6 1 1 1 2 2 2 0 Succinylarginine dihydrolase Methyltransf_5 PF01795.19 KPI85308.1 - 7e-29 101.3 0.0 1.1e-28 100.6 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family Methyltransf_31 PF13847.6 KPI85308.1 - 0.00021 21.1 0.0 0.0083 15.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KPI85308.1 - 0.013 15.0 0.0 0.041 13.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.12 KPI85308.1 - 0.084 13.5 0.0 1 10.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain SIR2 PF02146.17 KPI85309.1 - 8.6e-36 123.5 0.0 2.1e-34 119.0 0.0 2.1 1 1 0 1 1 1 1 Sir2 family PAS_8 PF13188.7 KPI85309.1 - 0.029 14.4 0.0 0.45 10.6 0.0 2.5 2 0 0 2 2 2 0 PAS domain zf-ribbon_3 PF13248.6 KPI85309.1 - 0.13 11.7 2.8 1.2 8.6 0.6 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_14 PF17978.1 KPI85309.1 - 0.28 11.6 2.6 0.8 10.2 0.1 2.6 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Cpn60_TCP1 PF00118.24 KPI85310.1 - 8.2e-160 532.6 7.3 9.6e-160 532.4 7.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RRM_1 PF00076.22 KPI85311.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PPR_3 PF13812.6 KPI85313.1 - 4e-05 23.6 0.0 9.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 KPI85313.1 - 0.00024 20.7 0.0 0.00057 19.5 0.0 1.7 2 0 0 2 2 2 1 PPR repeat PPR_2 PF13041.6 KPI85313.1 - 0.0019 18.4 0.0 0.011 15.9 0.0 2.4 2 1 1 3 3 3 2 PPR repeat family PPR PF01535.20 KPI85313.1 - 0.012 15.8 0.3 0.038 14.2 0.1 2.0 2 0 0 2 2 2 0 PPR repeat TetR_C_16 PF17920.1 KPI85313.1 - 0.44 10.8 8.0 0.62 10.3 0.4 3.1 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain C2-C2_1 PF11618.8 KPI85314.1 - 3.6e-27 95.2 2.2 1.1e-26 93.6 0.0 2.7 3 0 0 3 3 3 1 First C2 domain of RPGR-interacting protein 1 GAS PF13851.6 KPI85314.1 - 0.0052 16.2 1.0 0.0052 16.2 1.0 4.3 4 1 0 5 5 5 3 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 KPI85314.1 - 8.2 5.4 33.3 2.9 6.9 1.0 4.2 2 1 2 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 TFIIF_alpha PF05793.12 KPI85315.1 - 2.3 6.7 3.4 3.5 6.1 3.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RICTOR_M PF14666.6 KPI85316.1 - 1.2e-22 79.6 0.0 7.6e-20 70.6 0.0 3.5 2 1 1 3 3 3 2 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 KPI85316.1 - 6.1e-14 52.3 0.6 5.7e-13 49.2 0.4 2.6 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N PF14664.6 KPI85316.1 - 9.1e-14 51.2 2.3 2.8e-13 49.6 0.3 2.4 2 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_V PF14668.6 KPI85316.1 - 3.8e-06 27.1 0.2 0.00011 22.4 0.0 3.3 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 EcsB PF05975.12 KPI85319.1 - 0.038 12.8 0.9 0.053 12.4 0.9 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB XPG_I PF00867.18 KPI85320.1 - 3.7e-17 62.5 0.6 4.1e-16 59.1 0.2 2.3 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 KPI85320.1 - 3.4e-16 59.6 0.0 1.4e-06 28.7 0.0 2.7 3 0 0 3 3 3 2 XPG N-terminal domain XPG_I_2 PF12813.7 KPI85320.1 - 0.0097 15.4 0.3 0.017 14.6 0.3 1.3 1 0 0 1 1 1 1 XPG domain containing Caveolin PF01146.17 KPI85323.1 - 0.031 14.2 0.1 0.31 11.0 0.1 2.0 2 0 0 2 2 2 0 Caveolin Peptidase_C2 PF00648.21 KPI85324.1 - 1.1e-33 116.6 0.0 1.8e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KPI85324.1 - 3.9e-28 98.5 0.0 1.2e-05 25.6 0.0 7.7 7 1 0 7 7 7 5 Calpain large subunit, domain III LRR_6 PF13516.6 KPI85324.1 - 0.056 13.5 0.2 26 5.2 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich repeat JHY PF15261.6 KPI85324.1 - 0.097 13.4 0.3 0.21 12.3 0.3 1.5 1 0 0 1 1 1 0 Jhy protein LRR_1 PF00560.33 KPI85324.1 - 0.14 12.8 0.3 82 4.4 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat Topoisom_bac PF01131.20 KPI85325.1 - 3.7e-76 256.8 0.0 1.7e-75 254.6 0.0 1.9 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KPI85325.1 - 7.7e-14 51.8 0.0 1.7e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Toprim_4 PF13662.6 KPI85325.1 - 0.014 15.8 0.1 0.065 13.7 0.0 2.0 2 0 0 2 2 2 0 Toprim domain Pkinase PF00069.25 KPI85326.1 - 5.6e-57 193.1 0.0 1.1e-56 192.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85326.1 - 1.5e-33 116.2 0.0 2.4e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Guanylate_cyc PF00211.20 KPI85326.1 - 0.015 14.9 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Kdo PF06293.14 KPI85326.1 - 0.016 14.6 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KPI85326.1 - 0.061 12.6 0.0 1.1 8.5 0.0 2.4 3 0 0 3 3 3 0 Kinase-like RPN6_N PF18055.1 KPI85327.1 - 0.01 16.2 0.1 0.37 11.2 0.0 3.0 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain Pkinase PF00069.25 KPI85328.1 - 2.4e-29 102.5 0.0 2.2e-28 99.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85328.1 - 8e-09 35.2 0.0 0.00022 20.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI85328.1 - 0.044 13.1 0.1 3.5 6.9 0.0 2.2 2 0 0 2 2 2 0 Kinase-like HEAT_2 PF13646.6 KPI85328.1 - 0.13 12.7 1.3 0.26 11.7 0.2 2.1 2 0 0 2 2 2 0 HEAT repeats LRR_4 PF12799.7 KPI85329.1 - 2e-11 43.9 6.4 0.013 15.9 0.1 6.9 5 1 4 9 9 9 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI85329.1 - 3.6e-11 42.2 27.9 0.028 14.5 0.1 10.2 12 0 0 12 12 12 5 Leucine Rich repeat LRR_1 PF00560.33 KPI85329.1 - 5.2e-05 23.2 15.2 0.99 10.2 0.0 8.6 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_8 PF13855.6 KPI85329.1 - 0.23 11.2 13.1 2.3 8.0 0.1 6.6 6 3 0 6 6 6 0 Leucine rich repeat PUF PF00806.19 KPI85330.1 - 0.072 12.8 0.3 20 5.1 0.0 4.4 5 0 0 5 5 5 0 Pumilio-family RNA binding repeat CHAT PF12770.7 KPI85331.1 - 3e-44 151.6 0.0 9e-44 150.0 0.0 1.9 1 1 0 1 1 1 1 CHAT domain LRR_6 PF13516.6 KPI85331.1 - 0.59 10.3 2.3 49 4.3 0.3 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Cdc6_C PF09079.11 KPI85332.1 - 0.072 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain MVP_shoulder PF11978.8 KPI85333.1 - 4e-42 143.0 0.0 6.9e-42 142.2 0.0 1.4 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.18 KPI85333.1 - 2.3e-28 98.1 1.7 7.2e-12 45.3 0.0 4.5 4 0 0 4 4 4 3 Major Vault Protein repeat domain Vault_3 PF17795.1 KPI85333.1 - 9.1e-28 96.1 0.0 2e-26 91.8 0.0 2.4 2 0 0 2 2 2 1 Major Vault Protein Repeat domain Vault_4 PF17796.1 KPI85333.1 - 3.7e-16 58.9 0.0 8.5e-14 51.4 0.0 3.2 3 0 0 3 3 3 1 Major Vault Protein repeat domain Vault_2 PF17794.1 KPI85333.1 - 4.4e-09 36.6 3.5 0.017 15.5 0.4 5.0 3 1 0 3 3 3 3 Major Vault Protein repeat domain DUF2543 PF10820.8 KPI85333.1 - 0.028 14.6 1.8 12 6.2 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2543) ELYS PF13934.6 KPI85334.1 - 0.022 14.7 1.4 0.026 14.5 0.0 1.8 2 0 0 2 2 2 0 Nuclear pore complex assembly EF-hand_7 PF13499.6 KPI85335.1 - 6.3e-17 61.8 2.9 1.1e-07 32.2 0.3 2.9 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KPI85335.1 - 1.1e-15 55.9 0.9 0.0024 17.3 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KPI85335.1 - 1.9e-13 49.1 0.7 0.00087 19.0 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KPI85335.1 - 5.5e-12 45.3 0.2 1.1e-05 25.1 0.3 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 KPI85335.1 - 0.00012 22.3 1.2 0.0016 18.8 0.0 2.5 1 1 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KPI85335.1 - 0.00048 19.5 3.0 0.57 9.8 0.2 3.5 3 0 0 3 3 3 1 EF hand DUF2267 PF10025.9 KPI85335.1 - 0.13 12.6 0.8 0.92 9.8 0.3 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) Herpes_BLRF2 PF05812.12 KPI85335.1 - 0.15 12.2 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Actin PF00022.19 KPI85336.1 - 3.9e-29 101.5 0.0 4.2e-28 98.1 0.0 2.3 1 1 0 1 1 1 1 Actin Mucin PF01456.17 KPI85336.1 - 0.19 11.7 7.6 0.4 10.7 7.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Hexokinase_2 PF03727.16 KPI85337.1 - 1e-63 215.0 0.0 1.5e-63 214.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KPI85337.1 - 1.7e-63 214.1 0.1 2.5e-63 213.6 0.1 1.3 1 0 0 1 1 1 1 Hexokinase Cyt-b5 PF00173.28 KPI85339.1 - 2.7e-46 155.6 0.5 6.7e-23 80.6 0.1 2.1 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain EFP_N PF08207.12 KPI85339.1 - 0.11 12.6 0.0 3.8 7.6 0.0 2.4 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain HET-S PF17108.5 KPI85340.1 - 0.13 12.0 0.8 0.28 11.0 0.1 1.9 2 0 0 2 2 2 0 N-terminal small S protein of HET, non-prionic Pkinase PF00069.25 KPI85342.1 - 6.4e-49 166.7 0.0 6.1e-48 163.5 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85342.1 - 1.1e-35 123.2 0.0 2.5e-34 118.7 0.0 2.5 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI85342.1 - 2.2e-05 24.0 0.2 9.5e-05 21.9 0.0 2.1 3 0 0 3 3 3 1 Kinase-like RIO1 PF01163.22 KPI85342.1 - 0.032 13.8 0.0 0.098 12.2 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 KPI85342.1 - 0.062 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SelR PF01641.18 KPI85344.1 - 0.0015 18.6 0.0 0.0029 17.7 0.0 1.5 1 0 0 1 1 1 1 SelR domain SRP14 PF02290.15 KPI85345.1 - 0.043 14.2 0.1 2.5 8.5 0.1 3.0 2 1 1 3 3 3 0 Signal recognition particle 14kD protein Torus PF16131.5 KPI85346.1 - 0.0044 17.7 3.8 2.9 8.6 0.1 3.3 3 0 0 3 3 3 2 Torus domain Xpo1 PF08389.12 KPI85347.1 - 9.7e-23 80.9 0.1 2.9e-21 76.1 0.0 2.9 2 0 0 2 2 2 1 Exportin 1-like protein PI3_PI4_kinase PF00454.27 KPI85348.1 - 2.6e-40 138.8 0.0 4e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KPI85348.1 - 2.6e-07 30.3 0.1 6e-07 29.2 0.1 1.7 1 0 0 1 1 1 1 FATC domain SF3A2 PF16835.5 KPI85349.1 - 5.3e-20 71.6 0.0 8.5e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 KPI85349.1 - 0.00015 22.0 0.6 0.00033 20.9 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KPI85349.1 - 0.0036 17.6 0.5 0.0071 16.6 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding CTU2 PF10288.9 KPI85349.1 - 0.081 13.2 1.2 0.13 12.5 1.2 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 MAGE_N PF12440.8 KPI85349.1 - 0.41 11.3 10.3 0.83 10.4 10.3 1.4 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal RXLR PF16810.5 KPI85349.1 - 6.2 7.2 6.1 12 6.3 6.0 1.5 1 1 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity Cullin PF00888.22 KPI85350.1 - 2.3e-13 49.6 0.0 3.9e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Cullin family MA3 PF02847.17 KPI85350.1 - 0.075 13.0 0.3 3 7.8 0.0 3.1 2 1 1 3 3 3 0 MA3 domain DUF1981 PF09324.10 KPI85350.1 - 0.19 11.6 0.0 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) PhyH PF05721.13 KPI85351.1 - 0.031 14.5 0.0 0.072 13.3 0.0 1.6 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) DUF4600 PF15372.6 KPI85351.1 - 0.073 13.5 0.3 0.14 12.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) LPD23 PF18838.1 KPI85353.1 - 0.016 15.0 1.8 0.043 13.6 0.1 2.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 23 Scaffolding_pro PF11418.8 KPI85353.1 - 0.77 10.4 7.8 5.9 7.5 0.2 3.4 3 0 0 3 3 3 0 Phi29 scaffolding protein Phage_holin_3_3 PF16083.5 KPI85354.1 - 0.078 13.1 1.9 0.094 12.8 0.7 1.7 1 1 0 1 1 1 0 LydA holin phage, holin superfamily III CLN3 PF02487.17 KPI85354.1 - 0.32 10.0 0.8 2.4 7.1 0.1 2.1 2 0 0 2 2 2 0 CLN3 protein PEX11 PF05648.14 KPI85355.1 - 2.5e-15 56.5 0.1 6.7e-15 55.2 0.1 1.6 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DUF4181 PF13789.6 KPI85355.1 - 0.12 12.6 0.2 0.18 12.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) PEX11 PF05648.14 KPI85356.1 - 3.7e-06 26.6 0.0 5.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DUF2985 PF11204.8 KPI85356.1 - 0.0013 18.8 0.2 2.5 8.3 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2985) Ribul_P_3_epim PF00834.19 KPI85357.1 - 4.8e-49 166.4 0.0 6e-49 166.1 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 KPI85357.1 - 0.089 12.4 0.0 5.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family GHMP_kinases_C PF08544.13 KPI85358.1 - 2.6e-09 37.3 0.1 6.9e-09 36.0 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KPI85358.1 - 6e-06 26.4 0.0 1.6e-05 25.0 0.0 1.8 1 1 0 1 1 1 1 GHMP kinases N terminal domain NDUF_B7 PF05676.13 KPI85359.1 - 5e-09 35.8 0.5 8.1e-09 35.1 0.5 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Baculo_VP39 PF04501.12 KPI85359.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 zf-RanBP PF00641.18 KPI85360.1 - 0.008 15.5 1.2 0.008 15.5 1.2 8.4 8 0 0 8 8 8 2 Zn-finger in Ran binding protein and others AstA PF04958.12 KPI85360.1 - 0.041 12.4 0.0 0.077 11.5 0.0 1.4 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit T2SSM PF04612.12 KPI85362.1 - 0.037 14.1 3.1 0.29 11.2 0.1 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M MatE PF01554.18 KPI85363.1 - 4.5e-29 101.2 37.6 1.2e-18 67.3 12.1 3.3 2 1 1 3 3 3 3 MatE NifU_N PF01592.16 KPI85364.1 - 4.1e-50 169.2 0.1 6.2e-50 168.6 0.1 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain Pro_isomerase PF00160.21 KPI85365.1 - 7e-31 107.6 0.0 2.4e-30 105.9 0.0 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Methyltransf_23 PF13489.6 KPI85366.1 - 1.3e-26 93.4 0.0 1.8e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI85366.1 - 0.00018 22.2 0.0 0.0019 18.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI85366.1 - 0.024 15.3 0.0 0.28 11.9 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_11 PF08241.12 KPI85366.1 - 0.033 14.8 0.0 1.1 10.0 0.0 3.1 4 0 0 4 4 4 0 Methyltransferase domain XPG_I_2 PF12813.7 KPI85367.1 - 6.4e-27 94.6 0.0 1.6e-26 93.3 0.0 1.6 2 0 0 2 2 2 1 XPG domain containing XPG_N PF00752.17 KPI85367.1 - 6.2e-20 71.6 0.0 1.3e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KPI85367.1 - 1.6e-19 70.0 0.1 3.8e-19 68.8 0.1 1.7 1 0 0 1 1 1 1 XPG I-region MatE PF01554.18 KPI85368.1 - 1.3e-28 99.7 30.1 3.7e-18 65.7 10.0 2.4 2 0 0 2 2 2 2 MatE DUF4181 PF13789.6 KPI85370.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4181) EnY2 PF10163.9 KPI85371.1 - 5.6e-08 33.1 0.0 6.6e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 FAD_binding_3 PF01494.19 KPI85372.1 - 2.7e-12 46.6 0.0 3.4e-11 43.0 0.0 2.6 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 KPI85372.1 - 0.027 13.5 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase PCO_ADO PF07847.12 KPI85373.1 - 3e-42 144.3 0.0 3.7e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 PCO_ADO CDO_I PF05995.12 KPI85373.1 - 0.0079 15.5 0.3 0.053 12.8 0.3 2.0 1 1 0 1 1 1 1 Cysteine dioxygenase type I Cupin_2 PF07883.11 KPI85373.1 - 0.031 14.0 0.1 0.51 10.1 0.0 2.3 2 0 0 2 2 2 0 Cupin domain Dehydratase_MU PF02288.15 KPI85375.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Dehydratase medium subunit Thioredoxin PF00085.20 KPI85378.1 - 1.3e-07 31.5 0.0 1.6e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KPI85378.1 - 0.0062 15.9 0.0 0.0095 15.3 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 KPI85378.1 - 0.009 15.9 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain Pkinase PF00069.25 KPI85379.1 - 4.2e-58 196.8 0.0 1.8e-36 125.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85379.1 - 3.3e-31 108.5 0.0 1.3e-22 80.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KPI85379.1 - 4.6e-06 26.7 0.5 0.03 14.2 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI85379.1 - 0.00072 19.0 0.0 0.004 16.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KPI85379.1 - 0.02 14.2 0.0 0.055 12.8 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI85379.1 - 0.03 13.3 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 KPI85379.1 - 0.079 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase NTF2 PF02136.20 KPI85380.1 - 7.8e-16 58.7 0.0 8.9e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 KPI85380.1 - 0.0012 18.8 0.0 0.0014 18.6 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 TPR_12 PF13424.6 KPI85381.1 - 6.6 7.1 8.9 1.1 9.6 0.8 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4379 PF14311.6 KPI85382.1 - 2.7e-24 85.3 27.7 5.8e-09 36.2 0.2 4.7 4 1 0 4 4 4 3 Probable Zinc-ribbon domain HypA PF01155.19 KPI85382.1 - 0.00028 20.9 16.7 0.064 13.3 1.1 4.3 3 1 1 4 4 4 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Nse PF11789.8 KPI85382.1 - 2 8.3 5.1 6.7 6.6 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit RTT107_BRCT_5 PF16770.5 KPI85383.1 - 0.007 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 KPI85383.1 - 0.02 15.3 0.0 0.041 14.3 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain ANAPC4_WD40 PF12894.7 KPI85384.1 - 1.6e-06 28.3 0.3 7.4e-05 23.0 0.1 3.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI85384.1 - 6.9e-05 23.5 0.3 0.12 13.3 0.0 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_2 PF13360.6 KPI85384.1 - 0.0017 17.9 1.3 0.021 14.4 0.3 2.2 1 1 0 2 2 2 1 PQQ-like domain PIG-X PF08320.12 KPI85385.1 - 8.5e-05 22.6 0.0 0.00032 20.7 0.0 1.8 1 1 0 1 1 1 1 PIG-X / PBN1 TraC PF07820.12 KPI85387.1 - 0.052 13.9 1.8 0.06 13.7 0.0 2.0 2 0 0 2 2 2 0 TraC-like protein Rick_17kDa_Anti PF05433.15 KPI85387.1 - 0.18 11.7 8.6 0.36 10.7 8.6 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain Tropomyosin_1 PF12718.7 KPI85388.1 - 0.0014 18.8 3.4 0.0014 18.8 3.4 4.0 3 1 1 4 4 4 1 Tropomyosin like ATG16 PF08614.11 KPI85388.1 - 0.017 15.3 2.1 0.017 15.3 2.1 4.4 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) bZIP_2 PF07716.15 KPI85388.1 - 0.041 14.0 0.8 0.041 14.0 0.8 6.4 4 1 0 5 5 5 0 Basic region leucine zipper Cnn_1N PF07989.11 KPI85388.1 - 0.089 13.0 26.3 0.72 10.0 1.0 5.4 4 2 1 5 5 5 0 Centrosomin N-terminal motif 1 DUF4973 PF16343.5 KPI85388.1 - 0.13 12.3 0.2 0.75 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4973) bZIP_1 PF00170.21 KPI85388.1 - 1 9.5 31.9 2.2 8.4 1.1 6.5 4 1 1 6 6 6 0 bZIP transcription factor Spc7 PF08317.11 KPI85388.1 - 1.9 7.3 40.4 0.93 8.3 3.0 3.8 3 1 0 3 3 3 0 Spc7 kinetochore protein MAD PF05557.13 KPI85388.1 - 2.5 6.3 43.9 0.34 9.2 5.1 3.7 2 1 1 3 3 3 0 Mitotic checkpoint protein CENP-F_leu_zip PF10473.9 KPI85388.1 - 8.7 6.4 46.7 0.19 11.7 6.4 4.7 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.18 KPI85388.1 - 10 6.5 17.1 0.59 10.4 1.1 4.3 4 0 0 4 4 4 0 Homeobox associated leucine zipper SNase PF00565.17 KPI85389.1 - 6.1e-17 62.0 0.0 8.9e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue TcfC PF16967.5 KPI85389.1 - 0.15 11.5 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 E-set like domain Golgin_A5 PF09787.9 KPI85390.1 - 0.026 14.0 12.8 0.29 10.5 5.0 2.6 3 0 0 3 3 3 0 Golgin subfamily A member 5 Tropomyosin_1 PF12718.7 KPI85390.1 - 0.26 11.5 9.9 0.37 11.0 0.2 2.6 2 0 0 2 2 2 0 Tropomyosin like DUF4407 PF14362.6 KPI85390.1 - 0.5 9.7 7.6 0.91 8.8 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HR1 PF02185.16 KPI85390.1 - 1.6 8.9 15.6 0.8 9.9 0.5 4.1 4 0 0 4 4 4 0 Hr1 repeat Phage_Mu_Gam PF07352.12 KPI85390.1 - 2.7 7.9 7.2 0.59 10.0 2.9 2.0 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein DUF848 PF05852.11 KPI85390.1 - 3 7.9 8.5 0.22 11.6 2.6 2.1 3 0 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Apolipoprotein PF01442.18 KPI85390.1 - 4.3 7.2 16.9 0.66 9.8 9.8 2.5 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Surfac_D-trimer PF09006.11 KPI85390.1 - 4.5 7.3 5.6 45 4.0 0.4 3.9 3 1 1 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation THOC7 PF05615.13 KPI85390.1 - 5.2 7.4 20.5 0.069 13.4 1.1 3.6 4 1 0 4 4 4 0 Tho complex subunit 7 Spc7 PF08317.11 KPI85390.1 - 8.2 5.2 11.4 1.2 8.0 2.6 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein DeoC PF01791.9 KPI85391.1 - 8.6e-12 45.2 4.5 1.1e-11 44.8 4.5 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase UPF0167 PF03691.14 KPI85391.1 - 0.035 13.9 0.3 0.059 13.2 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) DeoC PF01791.9 KPI85392.1 - 2.3e-07 30.7 1.1 2.9e-07 30.3 1.1 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase His_Phos_1 PF00300.22 KPI85393.1 - 3.5e-33 114.9 0.7 5.7e-24 84.9 0.1 2.9 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.18 KPI85393.1 - 5.2e-17 61.9 1.0 3.7e-10 39.5 0.0 3.3 3 0 0 3 3 3 3 6-phosphofructo-2-kinase AAA_33 PF13671.6 KPI85393.1 - 0.0078 16.4 1.8 0.024 14.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain EPF PF17181.4 KPI85393.1 - 3 7.9 5.8 1.4 8.9 3.2 1.9 2 0 0 2 2 2 0 Epidermal patterning factor proteins DnaJ PF00226.31 KPI85394.1 - 3.3e-05 23.9 0.0 7.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.25 KPI85395.1 - 7e-24 84.6 0.7 4.4e-14 52.5 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85395.1 - 2.7e-05 23.6 1.1 0.072 12.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI85395.1 - 0.0052 16.1 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PPI_Ypi1 PF07491.11 KPI85396.1 - 6.3e-16 58.0 0.8 6.3e-16 58.0 0.8 2.1 3 0 0 3 3 3 1 Protein phosphatase inhibitor IMUP PF15761.5 KPI85396.1 - 0.0004 21.1 5.8 0.00055 20.6 5.8 1.3 1 0 0 1 1 1 1 Immortalisation up-regulated protein FRQ PF09421.10 KPI85396.1 - 0.013 13.6 3.4 0.015 13.4 3.4 1.0 1 0 0 1 1 1 0 Frequency clock protein AF-4 PF05110.13 KPI85396.1 - 0.019 13.1 5.1 0.021 12.9 5.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF755 PF05501.11 KPI85396.1 - 0.047 14.0 3.9 0.075 13.3 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) EF-hand_7 PF13499.6 KPI85397.1 - 0.064 13.7 0.1 0.14 12.6 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KPI85397.1 - 0.18 11.5 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 EF hand MCD PF05292.11 KPI85398.1 - 3.1e-59 200.6 0.0 6.1e-38 130.9 0.0 3.2 2 1 0 2 2 2 2 Malonyl-CoA decarboxylase C-terminal domain ELH PF02323.15 KPI85398.1 - 0.046 13.1 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 Egg-laying hormone precursor Uso1_p115_C PF04871.13 KPI85398.1 - 0.37 11.2 2.8 26 5.2 1.5 2.7 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region HEAT PF02985.22 KPI85399.1 - 1.5e-08 34.2 21.8 0.00069 19.7 0.2 9.8 11 0 0 11 11 9 3 HEAT repeat HEAT_EZ PF13513.6 KPI85399.1 - 1.2e-06 28.9 44.4 0.12 12.9 0.7 11.5 10 2 2 12 12 10 5 HEAT-like repeat HEAT_2 PF13646.6 KPI85399.1 - 3.8e-06 27.2 27.9 3e-05 24.3 0.3 7.8 7 2 2 10 10 10 2 HEAT repeats CLASP_N PF12348.8 KPI85399.1 - 8.8e-06 25.4 0.1 2.6 7.5 0.0 5.3 4 2 0 5 5 5 2 CLASP N terminal Cnd1 PF12717.7 KPI85399.1 - 1e-05 25.7 1.1 0.0028 17.7 0.0 4.5 4 2 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DUF3437 PF11919.8 KPI85399.1 - 5.3e-05 23.0 0.5 0.0019 18.1 0.0 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF3437) IBN_N PF03810.19 KPI85399.1 - 8.8e-05 22.4 0.1 0.00076 19.3 0.0 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain GLE1 PF07817.13 KPI85399.1 - 0.0068 15.6 0.3 0.14 11.4 0.0 2.5 2 0 0 2 2 2 1 GLE1-like protein Jnk-SapK_ap_N PF09744.9 KPI85399.1 - 0.037 14.2 0.2 0.089 13.0 0.2 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 RIX1 PF08167.12 KPI85399.1 - 0.07 12.9 1.7 12 5.6 0.1 3.6 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis TFCD_C PF12612.8 KPI85399.1 - 0.084 12.7 0.1 11 5.8 0.1 3.0 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal Vac14_Fab1_bd PF12755.7 KPI85399.1 - 0.089 13.4 0.0 10 6.8 0.0 3.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 KPI85399.1 - 0.12 12.6 0.1 2.9 8.1 0.0 3.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 KPI85399.1 - 6.1 7.0 17.6 0.63 10.2 0.3 5.6 6 0 0 6 6 4 0 Armadillo/beta-catenin-like repeat Vps39_2 PF10367.9 KPI85400.1 - 3.5e-07 30.7 0.0 7.8e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Zn_ribbon_17 PF17120.5 KPI85400.1 - 0.17 11.5 1.3 0.42 10.3 1.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type AAA_23 PF13476.6 KPI85402.1 - 1.9e-27 97.1 0.0 1.9e-27 97.1 0.0 7.4 2 2 3 6 6 2 1 AAA domain SMC_N PF02463.19 KPI85402.1 - 2.4e-09 36.9 21.3 7.7e-05 22.2 0.0 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KPI85402.1 - 1.9e-08 34.5 0.0 0.001 18.9 0.1 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KPI85402.1 - 1e-07 32.1 0.0 5.9e-07 29.6 0.0 2.4 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 KPI85402.1 - 1.2e-06 28.5 4.4 0.00049 19.9 0.1 3.8 3 1 0 3 3 2 2 AAA ATPase domain AAA_29 PF13555.6 KPI85402.1 - 0.0015 18.2 0.0 0.0039 16.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Uso1_p115_C PF04871.13 KPI85402.1 - 0.0023 18.3 4.6 0.0023 18.3 4.6 10.9 3 3 7 11 11 9 1 Uso1 / p115 like vesicle tethering protein, C terminal region ABC_tran PF00005.27 KPI85402.1 - 0.0029 18.1 0.0 0.0029 18.1 0.0 6.1 4 2 0 4 4 3 2 ABC transporter RT_RNaseH PF17917.1 KPI85402.1 - 0.13 12.5 5.4 12 6.2 0.1 3.7 3 0 0 3 3 3 0 RNase H-like domain found in reverse transcriptase RsgA_GTPase PF03193.16 KPI85402.1 - 0.15 11.9 2.7 0.45 10.4 0.0 3.3 3 0 0 3 3 3 0 RsgA GTPase MMR_HSR1 PF01926.23 KPI85402.1 - 0.8 9.8 3.2 3.3 7.8 0.1 3.8 3 0 0 3 3 3 0 50S ribosome-binding GTPase DASH_Dam1 PF08653.10 KPI85402.1 - 3.1 7.7 5.7 36 4.3 0.1 5.0 4 0 0 4 4 4 0 DASH complex subunit Dam1 Pkinase PF00069.25 KPI85403.1 - 1.5e-63 214.6 0.0 1.8e-63 214.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85403.1 - 3.8e-40 137.8 0.0 4.6e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI85403.1 - 5.5e-06 25.9 0.0 1.1e-05 25.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KPI85403.1 - 0.00037 19.5 0.1 0.0006 18.9 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI85403.1 - 0.0032 17.4 1.6 0.021 14.8 0.8 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 KPI85403.1 - 0.0035 17.0 0.1 0.71 9.5 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KPI85403.1 - 0.0067 15.2 0.0 0.0093 14.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KPI85403.1 - 0.0069 15.8 0.1 0.012 14.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KPI85403.1 - 0.027 13.5 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.9 KPI85403.1 - 0.043 13.3 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 KPI85403.1 - 0.11 12.1 0.1 0.36 10.4 0.0 1.8 2 0 0 2 2 2 0 RIO1 family TPR_2 PF07719.17 KPI85405.1 - 3.3e-07 29.9 1.8 1.1 9.6 0.2 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI85405.1 - 2.6e-06 27.0 3.5 0.76 9.7 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI85405.1 - 7.4e-05 23.3 0.6 0.033 14.8 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85405.1 - 0.00027 21.1 0.1 0.035 14.4 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85405.1 - 0.054 13.7 2.8 5.5 7.5 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85405.1 - 0.066 13.7 0.2 17 6.0 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-MYND PF01753.18 KPI85405.1 - 1 9.5 15.3 1.3 9.2 14.0 2.0 1 1 0 1 1 1 0 MYND finger Carboxyl_trans PF01039.22 KPI85406.1 - 5.5e-175 582.7 0.0 6.3e-175 582.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KPI85406.1 - 0.00072 19.1 0.2 0.0027 17.3 0.0 1.9 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) ACCA PF03255.14 KPI85406.1 - 0.11 12.3 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit EII-Sor PF03609.14 KPI85407.1 - 0.16 11.4 0.9 0.22 10.9 0.9 1.2 1 0 0 1 1 1 0 PTS system sorbose-specific iic component Carb_anhydrase PF00194.21 KPI85408.1 - 5.7e-31 108.0 0.0 8.7e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase SOG2 PF10428.9 KPI85408.1 - 6.6 5.8 26.7 9.7 5.3 26.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RNB PF00773.19 KPI85411.1 - 6.2e-91 305.1 0.0 9.9e-91 304.4 0.0 1.3 1 0 0 1 1 1 1 RNB domain Carn_acyltransf PF00755.20 KPI85412.1 - 5.8e-06 25.2 0.0 8.8e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase FYVE PF01363.21 KPI85416.1 - 2.4e-11 43.6 7.3 4.5e-11 42.7 7.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger APG6_N PF17675.1 KPI85416.1 - 0.0016 19.0 11.9 0.0016 19.0 11.9 1.8 2 0 0 2 2 2 1 Apg6 coiled-coil region ADIP PF11559.8 KPI85416.1 - 0.003 17.6 10.0 0.0044 17.1 10.0 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding FYVE_2 PF02318.16 KPI85416.1 - 0.022 15.0 5.5 0.022 15.0 5.5 2.6 2 1 1 3 3 3 0 FYVE-type zinc finger Macoilin PF09726.9 KPI85416.1 - 0.025 13.1 4.0 0.026 13.1 4.0 1.0 1 0 0 1 1 1 0 Macoilin family zf-UDP PF14569.6 KPI85416.1 - 0.059 13.5 5.1 0.13 12.4 5.1 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Phage_GPO PF05929.11 KPI85416.1 - 0.072 12.7 10.5 0.035 13.7 8.5 1.5 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4164 PF13747.6 KPI85416.1 - 0.12 12.6 9.5 0.21 11.9 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) C1_2 PF03107.16 KPI85416.1 - 0.12 12.7 6.7 0.26 11.6 6.7 1.6 1 0 0 1 1 1 0 C1 domain zinc-ribbons_6 PF07191.12 KPI85416.1 - 0.13 12.2 6.0 1.4 9.0 6.0 2.3 1 1 0 1 1 1 0 zinc-ribbons zf-B_box PF00643.24 KPI85416.1 - 0.18 12.0 6.3 0.26 11.5 2.0 2.4 2 0 0 2 2 2 0 B-box zinc finger HAUS-augmin3 PF14932.6 KPI85416.1 - 0.45 10.1 14.0 0.59 9.7 14.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Uso1_p115_C PF04871.13 KPI85416.1 - 0.68 10.3 19.4 2.7 8.4 15.0 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Exonuc_VII_L PF02601.15 KPI85416.1 - 0.8 9.2 15.4 1.1 8.8 15.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Zn-ribbon_8 PF09723.10 KPI85416.1 - 0.99 9.6 9.2 7.7 6.7 5.5 2.9 1 1 1 2 2 2 0 Zinc ribbon domain DUF4407 PF14362.6 KPI85416.1 - 1 8.7 14.9 1.2 8.4 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.9 KPI85416.1 - 1.2 7.9 10.0 1.5 7.6 10.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FemAB PF02388.16 KPI85416.1 - 1.4 7.7 11.0 1.8 7.3 11.0 1.1 1 0 0 1 1 1 0 FemAB family zf-HIT PF04438.16 KPI85416.1 - 2.8 7.9 10.7 0.95 9.4 5.1 2.4 2 0 0 2 2 2 0 HIT zinc finger Spc7 PF08317.11 KPI85416.1 - 3.2 6.5 15.9 4.3 6.1 15.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein zf_UBZ PF18439.1 KPI85416.1 - 5.9 6.6 8.0 5.8 6.6 0.2 2.8 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF4140 PF13600.6 KPI85416.1 - 6.4 7.3 19.5 39 4.8 7.8 3.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Terminase_4 PF05119.12 KPI85417.1 - 0.11 12.9 0.2 0.4 11.1 0.1 1.9 2 0 0 2 2 2 0 Phage terminase, small subunit Ribosomal_L38e PF01781.18 KPI85418.1 - 9.8e-30 102.5 5.2 1.2e-29 102.2 5.2 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family AMP-binding PF00501.28 KPI85420.1 - 2.2e-86 290.1 0.2 2.9e-86 289.7 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Ndr PF03096.14 KPI85420.1 - 0.14 10.8 0.0 0.27 9.9 0.0 1.4 1 0 0 1 1 1 0 Ndr family Pkinase PF00069.25 KPI85422.1 - 2.1e-57 194.5 0.0 2.6e-57 194.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85422.1 - 3.6e-29 101.8 0.0 5.3e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI85422.1 - 9e-05 21.4 0.0 0.00013 20.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KPI85422.1 - 0.00058 18.9 0.1 0.0011 18.0 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KPI85422.1 - 0.0039 16.6 0.0 0.0065 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI85422.1 - 0.0066 16.4 1.1 3.6 7.4 0.1 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 KPI85422.1 - 0.021 14.4 0.1 0.04 13.5 0.1 1.5 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 KPI85422.1 - 0.032 13.5 0.0 0.08 12.3 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Aldedh PF00171.22 KPI85423.1 - 2.3e-102 342.9 0.0 2.8e-102 342.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf_CCCH_4 PF18345.1 KPI85424.1 - 6e-07 29.3 10.2 0.0012 18.9 0.3 3.2 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 KPI85424.1 - 2.4e-06 27.3 13.8 0.0043 16.9 0.6 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KPI85424.1 - 8.1e-05 23.3 13.5 0.002 18.8 0.4 3.0 2 1 1 3 3 3 2 Torus domain RRM_1 PF00076.22 KPI85424.1 - 0.00034 20.4 0.0 0.0009 19.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 KPI85424.1 - 0.011 15.7 1.8 0.026 14.6 1.8 1.7 1 0 0 1 1 1 0 Zinc knuckle DUF4023 PF13215.6 KPI85424.1 - 0.019 14.9 3.0 0.036 14.1 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) zf-CCCH_4 PF18044.1 KPI85424.1 - 0.06 13.2 1.9 0.06 13.2 1.9 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger zf-C2H2_3 PF13878.6 KPI85425.1 - 5.7e-09 35.7 0.6 1.6e-08 34.2 0.6 1.8 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO zf-MYND PF01753.18 KPI85425.1 - 0.094 12.8 0.8 0.38 10.9 0.8 2.1 1 0 0 1 1 1 0 MYND finger ABC_tran PF00005.27 KPI85426.1 - 1.2e-46 158.6 4.0 1.4e-23 83.9 0.0 3.6 4 0 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 KPI85426.1 - 3.5e-24 84.6 2.5 3.5e-24 84.6 2.5 3.6 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.6 KPI85426.1 - 7.3e-16 58.8 15.7 5.4e-05 23.1 0.2 4.8 4 1 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI85426.1 - 1e-09 38.2 1.2 0.02 14.3 0.0 4.2 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KPI85426.1 - 2.9e-07 30.1 0.4 0.015 15.1 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 KPI85426.1 - 4.4e-07 30.5 0.4 0.015 15.7 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 KPI85426.1 - 4.4e-07 30.1 1.7 0.012 15.8 0.0 3.5 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KPI85426.1 - 9.3e-07 28.9 0.3 0.063 13.4 0.0 3.2 3 0 0 3 3 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI85426.1 - 7.5e-06 25.9 0.1 0.049 13.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 KPI85426.1 - 5.6e-05 23.0 12.0 0.14 11.9 0.1 4.4 3 1 1 4 4 4 2 AAA ATPase domain AAA_28 PF13521.6 KPI85426.1 - 0.00015 22.0 3.6 0.051 13.8 0.0 3.2 4 0 0 4 4 2 2 AAA domain AAA_22 PF13401.6 KPI85426.1 - 0.0002 21.6 0.0 0.29 11.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI85426.1 - 0.00062 19.5 0.0 1.5 8.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain NACHT PF05729.12 KPI85426.1 - 0.00068 19.6 0.1 0.85 9.5 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.6 KPI85426.1 - 0.00069 20.2 4.4 0.017 15.7 0.0 3.3 4 0 0 4 4 2 1 AAA domain AAA_23 PF13476.6 KPI85426.1 - 0.00076 20.0 0.5 0.021 15.3 0.2 4.6 5 0 0 5 5 5 2 AAA domain TsaE PF02367.17 KPI85426.1 - 0.0013 18.7 0.2 0.8 9.7 0.1 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 KPI85426.1 - 0.0017 18.6 0.3 2.4 8.4 0.0 2.9 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 KPI85426.1 - 0.0019 18.6 0.2 1.1 9.7 0.1 3.1 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KPI85426.1 - 0.002 17.9 0.1 2 8.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 KPI85426.1 - 0.0036 17.4 3.6 1.9 8.5 0.0 4.0 4 1 0 4 4 4 1 Dynamin family Zeta_toxin PF06414.12 KPI85426.1 - 0.0042 16.4 0.0 0.7 9.1 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin cobW PF02492.19 KPI85426.1 - 0.0049 16.5 0.0 1.6 8.3 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 KPI85426.1 - 0.005 16.4 0.1 4.7 6.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 KPI85426.1 - 0.0051 16.6 0.1 0.22 11.2 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 KPI85426.1 - 0.0073 16.3 0.1 10 6.1 0.0 3.4 3 1 1 4 4 3 0 AAA domain RNA_helicase PF00910.22 KPI85426.1 - 0.0082 16.5 0.0 2.1 8.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Arf PF00025.21 KPI85426.1 - 0.012 15.1 3.3 2.1 7.8 0.0 3.2 4 0 0 4 4 3 0 ADP-ribosylation factor family Septin PF00735.18 KPI85426.1 - 0.02 14.2 1.0 2.6 7.3 0.0 3.0 3 0 0 3 3 3 0 Septin SRP54 PF00448.22 KPI85426.1 - 0.022 14.4 0.2 5.4 6.6 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_27 PF13514.6 KPI85426.1 - 0.024 14.2 2.8 4.9 6.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KPI85426.1 - 0.025 14.1 0.1 1.6 8.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 KPI85426.1 - 0.032 14.2 0.0 8.7 6.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MukB PF04310.12 KPI85426.1 - 0.041 13.7 0.5 1.7 8.4 0.0 2.5 2 1 0 2 2 2 0 MukB N-terminal FtsK_SpoIIIE PF01580.18 KPI85426.1 - 0.066 12.6 0.4 3.9 6.8 0.0 2.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_13 PF13166.6 KPI85426.1 - 0.18 10.4 0.0 0.18 10.4 0.0 3.7 4 1 0 4 4 4 0 AAA domain ATP_bind_1 PF03029.17 KPI85426.1 - 0.5 10.1 2.1 29 4.3 0.0 3.1 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF4558 PF15104.6 KPI85428.1 - 0.0088 16.1 3.2 0.017 15.1 3.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4558) Acetyltransf_1 PF00583.25 KPI85429.1 - 3.5e-07 30.5 0.0 4.6e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KPI85429.1 - 9.2e-07 28.8 0.0 1.2e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI85429.1 - 1.3e-06 28.7 0.1 1.8e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Epsilon_antitox PF08998.11 KPI85429.1 - 0.079 13.2 0.1 0.31 11.3 0.1 1.9 2 0 0 2 2 2 0 Bacterial epsilon antitoxin LRR_4 PF12799.7 KPI85430.1 - 1.9e-12 47.2 12.6 1.7e-05 25.0 0.8 4.3 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85430.1 - 1.6e-10 40.6 14.9 0.00012 21.8 1.0 4.0 4 0 0 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 KPI85430.1 - 2.1e-10 40.4 4.8 4.1e-09 36.2 0.8 2.4 1 1 0 2 2 2 2 Leucine-rich repeat ATG16 PF08614.11 KPI85430.1 - 0.0068 16.7 11.9 0.0068 16.7 11.9 4.6 4 1 1 5 5 5 1 Autophagy protein 16 (ATG16) LRR_6 PF13516.6 KPI85430.1 - 0.017 15.1 7.6 0.28 11.4 0.3 4.5 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KPI85430.1 - 2 9.3 8.0 34 5.5 0.0 5.1 5 1 0 5 5 5 0 Leucine Rich Repeat Tup_N PF08581.10 KPI85430.1 - 2.1 8.7 9.2 6.4 7.2 3.5 2.6 2 0 0 2 2 2 0 Tup N-terminal YabA PF06156.13 KPI85430.1 - 8 7.2 11.8 2.2 9.0 4.7 2.7 1 1 1 2 2 2 0 Initiation control protein YabA KELK PF15796.5 KPI85431.1 - 0.45 11.0 3.2 7 7.2 0.9 2.7 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Cep57_MT_bd PF06657.13 KPI85431.1 - 1.5 9.3 4.1 0.75 10.3 0.7 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 CtaG_Cox11 PF04442.14 KPI85432.1 - 5.9e-47 159.5 0.1 7.9e-47 159.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DNA_primase_lrg PF04104.14 KPI85433.1 - 2.7e-81 272.9 0.0 3.4e-81 272.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit GlutR_dimer PF00745.20 KPI85433.1 - 0.093 13.2 0.3 0.24 11.8 0.0 1.8 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Acyltransferase PF01553.21 KPI85434.1 - 4.8e-13 48.9 0.0 1.3e-12 47.5 0.0 1.8 1 1 0 1 1 1 1 Acyltransferase zf_UBZ PF18439.1 KPI85434.1 - 0.021 14.4 0.2 0.041 13.5 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger ATP-synt_D PF01813.17 KPI85434.1 - 0.09 12.6 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 ATP synthase subunit D Minor_capsid_3 PF12691.7 KPI85435.1 - 0.1 13.0 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage Met_10 PF02475.16 KPI85436.1 - 4.6e-42 144.0 0.0 1.1e-38 133.0 0.0 2.2 2 0 0 2 2 2 2 Met-10+ like-protein Methyltransf_15 PF09445.10 KPI85436.1 - 0.00029 20.4 0.0 0.00048 19.7 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 KPI85436.1 - 0.00029 20.4 0.0 0.00056 19.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain tRNA_U5-meth_tr PF05958.11 KPI85436.1 - 0.014 14.4 0.0 0.031 13.3 0.0 1.5 1 1 1 2 2 2 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 KPI85436.1 - 0.1 13.4 0.0 0.44 11.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain LapA_dom PF06305.11 KPI85436.1 - 0.15 11.9 0.2 0.32 10.9 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Methyltransf_31 PF13847.6 KPI85436.1 - 0.19 11.5 0.0 0.55 10.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain PrmA PF06325.13 KPI85436.1 - 0.2 11.0 0.0 0.32 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RRM_1 PF00076.22 KPI85437.1 - 2.4e-12 46.5 0.2 9.5e-08 31.8 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI85437.1 - 0.0012 18.4 0.1 0.0042 16.7 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI85437.1 - 0.0055 16.8 0.1 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif DAO_C PF16901.5 KPI85437.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase RRM_1 PF00076.22 KPI85438.1 - 3.6e-08 33.1 0.0 2.1e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UBA2_C PF16195.5 KPI85439.1 - 0.27 11.9 2.1 0.61 10.8 2.1 1.5 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus Aa_trans PF01490.18 KPI85440.1 - 1.4e-54 185.4 17.4 1.6e-54 185.2 17.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI85440.1 - 3.3e-08 33.0 11.8 3.3e-08 33.0 11.8 2.3 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family WD40 PF00400.32 KPI85441.1 - 4e-15 55.9 15.6 0.0014 19.4 0.4 6.5 7 0 0 7 7 6 3 WD domain, G-beta repeat Nup160 PF11715.8 KPI85441.1 - 3.5e-05 22.7 5.1 0.033 12.8 2.5 3.1 1 1 1 2 2 2 1 Nucleoporin Nup120/160 BLOC1_2 PF10046.9 KPI85441.1 - 0.011 16.0 2.4 0.011 16.0 2.4 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_TATA_bd PF12325.8 KPI85441.1 - 0.011 15.9 10.0 0.011 15.9 10.0 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding HOOK PF05622.12 KPI85441.1 - 0.027 12.6 28.4 0.17 10.0 6.5 2.1 1 1 1 2 2 2 0 HOOK protein ANAPC4_WD40 PF12894.7 KPI85441.1 - 0.1 12.9 0.3 12 6.3 0.0 3.8 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KPI85441.1 - 0.12 12.9 0.0 0.73 10.4 0.0 2.4 2 0 0 2 2 2 0 PQQ-like domain ATG16 PF08614.11 KPI85441.1 - 0.76 10.0 37.8 0.94 9.7 29.6 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.22 KPI85441.1 - 1.1 9.5 22.3 16 5.7 4.8 3.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain bZIP_1 PF00170.21 KPI85441.1 - 1.1 9.4 29.5 1.4 9.1 2.7 4.0 1 1 1 3 3 3 0 bZIP transcription factor OmpH PF03938.14 KPI85441.1 - 4.6 7.6 31.9 7.6 6.9 12.5 2.5 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) FAM76 PF16046.5 KPI85441.1 - 6.2 6.1 13.4 13 5.1 13.4 1.5 1 0 0 1 1 1 0 FAM76 protein YabA PF06156.13 KPI85441.1 - 8.7 7.1 19.9 9.3 7.0 3.7 3.4 1 1 1 2 2 2 0 Initiation control protein YabA Pkinase PF00069.25 KPI85442.1 - 6.2e-49 166.7 0.0 1.9e-27 96.3 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85442.1 - 2.2e-30 105.8 0.0 2.1e-20 73.1 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase FHA PF00498.26 KPI85442.1 - 3.9e-09 36.7 0.0 4.9e-08 33.2 0.0 2.5 1 1 0 1 1 1 1 FHA domain Kinase-like PF14531.6 KPI85442.1 - 2.7e-05 23.6 0.0 0.0028 17.0 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Yop-YscD_cpl PF16697.5 KPI85442.1 - 0.0012 19.2 0.0 0.0041 17.4 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RIO1 PF01163.22 KPI85442.1 - 0.046 13.3 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family MRP-L28 PF09812.9 KPI85443.1 - 0.03 14.5 0.0 0.061 13.5 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 ALMT PF11744.8 KPI85443.1 - 0.12 11.1 0.1 0.16 10.7 0.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pkinase PF00069.25 KPI85444.1 - 4.5e-65 219.6 0.0 5.8e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85444.1 - 7e-32 110.7 0.0 1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI85444.1 - 5.9e-06 25.8 0.3 9.9e-06 25.1 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI85444.1 - 8.2e-05 21.7 0.4 0.00011 21.2 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KPI85444.1 - 0.00058 19.3 0.0 0.0018 17.6 0.0 1.8 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI85444.1 - 0.0047 15.8 0.1 0.0047 15.8 0.1 1.7 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 KPI85444.1 - 0.025 14.2 0.2 0.055 13.1 0.2 1.6 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 KPI85444.1 - 0.041 12.9 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 KPI85444.1 - 0.063 12.9 0.1 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 NACHT PF05729.12 KPI85446.1 - 0.031 14.2 0.0 0.79 9.6 0.0 2.7 3 0 0 3 3 3 0 NACHT domain SRP-alpha_N PF04086.13 KPI85446.1 - 0.11 12.3 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PIG-F PF06699.11 KPI85447.1 - 0.0017 18.6 0.1 0.31 11.2 0.0 2.2 2 0 0 2 2 2 2 GPI biosynthesis protein family Pig-F Toxin_GhoT_OrtT PF10753.9 KPI85447.1 - 0.004 17.3 1.7 0.01 16.0 1.7 1.6 1 0 0 1 1 1 1 Toxin GhoT_OrtT Complex1_LYR PF05347.15 KPI85448.1 - 5.9e-09 35.9 1.4 9.9e-09 35.1 1.4 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) UPF0113 PF03657.13 KPI85449.1 - 3.7e-19 68.8 0.0 1.5e-18 66.8 0.0 1.8 2 0 0 2 2 2 1 UPF0113 PUA domain UPF0113_N PF17833.1 KPI85449.1 - 2.9e-18 66.2 0.1 4.7e-18 65.5 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain DUF5317 PF17248.2 KPI85449.1 - 0.041 13.9 0.0 0.078 13.0 0.0 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5317) Baculo_LEF-11 PF06385.12 KPI85449.1 - 0.13 12.8 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 Baculovirus LEF-11 protein Syntaxin PF00804.25 KPI85450.1 - 1.1e-08 35.0 12.3 1.9e-08 34.3 12.3 1.4 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 KPI85450.1 - 6e-05 23.0 1.3 8.2e-05 22.5 0.1 1.9 2 0 0 2 2 2 1 SNARE domain GSP_synth PF03738.14 KPI85450.1 - 0.0044 16.2 0.3 0.01 15.0 0.3 1.6 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp GSCFA PF08885.11 KPI85450.1 - 0.0059 16.3 1.4 0.02 14.6 0.3 2.0 2 0 0 2 2 2 1 GSCFA family DUF1664 PF07889.12 KPI85450.1 - 0.015 15.3 5.9 0.096 12.7 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 KPI85450.1 - 0.019 15.2 3.2 0.019 15.2 3.2 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 MCPsignal PF00015.21 KPI85450.1 - 0.05 13.4 0.7 0.087 12.6 0.2 1.7 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CLZ PF16526.5 KPI85450.1 - 0.069 13.5 1.1 0.069 13.5 1.1 3.2 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DASH_Dam1 PF08653.10 KPI85450.1 - 0.39 10.5 1.3 19 5.2 0.1 2.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 TMPIT PF07851.13 KPI85450.1 - 0.6 9.3 10.6 0.99 8.6 3.1 2.1 1 1 1 2 2 2 0 TMPIT-like protein Fzo_mitofusin PF04799.13 KPI85450.1 - 0.9 9.1 8.7 4.8 6.7 0.4 2.9 2 1 1 3 3 3 0 fzo-like conserved region Baculo_PEP_C PF04513.12 KPI85450.1 - 2.6 8.1 4.2 42 4.2 0.1 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3510 PF12022.8 KPI85450.1 - 4.2 7.8 7.4 1.7 9.0 2.2 2.6 2 2 0 2 2 2 0 Domain of unknown function (DUF3510) ACCA PF03255.14 KPI85450.1 - 5.8 6.8 10.4 0.54 10.1 0.6 3.0 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Aminotran_1_2 PF00155.21 KPI85451.1 - 1.2e-53 182.7 0.0 1.3e-53 182.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KPI85451.1 - 0.00021 19.9 0.0 0.00032 19.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KPI85451.1 - 0.00089 18.3 0.0 0.002 17.1 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KPI85451.1 - 0.0026 17.1 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cas_Cmr5 PF09701.10 KPI85451.1 - 0.19 12.0 0.1 34 4.8 0.0 2.6 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_Cmr5) Lipocalin_9 PF17186.4 KPI85452.1 - 2.7e-06 27.7 0.0 3.3e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Lipocalin-like domain ThiF PF00899.21 KPI85453.1 - 4.9e-73 245.5 0.0 1.6e-58 198.0 0.1 2.6 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KPI85453.1 - 1.2e-59 202.3 0.0 1.9e-59 201.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_4HB PF16191.5 KPI85453.1 - 1.2e-11 44.6 0.1 2.5e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Rhamno_transf PF11316.8 KPI85453.1 - 0.13 11.6 0.0 0.33 10.3 0.0 1.6 1 0 0 1 1 1 0 Putative rhamnosyl transferase zf-CCHC_2 PF13696.6 KPI85455.1 - 4e-08 32.9 8.2 1e-07 31.6 8.2 1.7 1 0 0 1 1 1 1 Zinc knuckle Zn-ribbon_8 PF09723.10 KPI85455.1 - 0.019 15.0 4.2 0.29 11.3 0.8 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-RING_4 PF14570.6 KPI85455.1 - 0.054 13.3 4.2 0.14 12.0 4.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 KPI85455.1 - 0.3 11.1 8.4 0.17 11.8 2.8 2.3 2 0 0 2 2 2 0 zinc-RING finger domain ADK_lid PF05191.14 KPI85455.1 - 0.34 10.9 4.8 12 6.0 0.1 3.0 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf-CCHC_3 PF13917.6 KPI85455.1 - 0.36 10.8 5.3 1.2 9.2 0.4 2.5 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 KPI85455.1 - 0.48 10.5 7.6 0.39 10.8 2.3 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-CCHC PF00098.23 KPI85455.1 - 1.7 8.9 9.8 0.23 11.6 4.5 2.3 2 0 0 2 2 2 0 Zinc knuckle FYVE PF01363.21 KPI85455.1 - 1.9 8.7 7.0 0.16 12.1 1.3 2.0 2 0 0 2 2 2 0 FYVE zinc finger DUF4428 PF14471.6 KPI85455.1 - 2.6 8.0 5.3 38 4.3 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) zinc_ribbon_10 PF10058.9 KPI85455.1 - 4.2 7.2 9.3 87 3.0 6.0 3.4 2 1 1 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-RING_2 PF13639.6 KPI85455.1 - 8.1 6.9 9.7 0.13 12.6 2.5 1.8 2 0 0 2 2 2 0 Ring finger domain NDUFA12 PF05071.16 KPI85456.1 - 2.4e-06 28.3 0.4 7.1e-06 26.8 0.4 1.8 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 ICMT PF04140.14 KPI85457.1 - 4.8e-20 71.8 1.3 4.8e-20 71.8 1.3 2.9 2 2 1 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KPI85457.1 - 1.9e-06 28.2 0.8 1.9e-06 28.2 0.8 2.5 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 KPI85457.1 - 0.00013 21.6 3.7 0.00013 21.6 3.7 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1295) PAF-AH_p_II PF03403.13 KPI85458.1 - 2e-25 89.1 0.0 4.9e-25 87.9 0.0 1.8 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 KPI85458.1 - 1.1e-08 34.3 0.0 5.7e-08 32.0 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 KPI85458.1 - 0.00019 22.1 0.0 0.00085 20.0 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KPI85458.1 - 0.00051 19.4 0.0 0.7 9.1 0.0 2.7 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 KPI85458.1 - 0.0011 18.1 0.0 0.88 8.5 0.0 2.2 2 0 0 2 2 2 2 Chlorophyllase Abhydrolase_1 PF00561.20 KPI85458.1 - 0.0038 16.9 0.0 0.0064 16.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Glyoxalase PF00903.25 KPI85459.1 - 7.6e-17 61.7 0.5 9.6e-17 61.4 0.5 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KPI85459.1 - 6e-09 36.2 0.0 8.3e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KPI85459.1 - 0.0019 18.3 0.0 0.57 10.3 0.0 2.4 1 1 2 3 3 3 3 Glyoxalase-like domain Glyoxalase_2 PF12681.7 KPI85459.1 - 0.0091 15.9 0.1 0.032 14.1 0.1 1.9 1 1 0 1 1 1 1 Glyoxalase-like domain CppA_N PF14506.6 KPI85459.1 - 0.016 15.3 0.0 0.02 15.0 0.0 1.4 1 1 0 1 1 1 0 CppA N-terminal Glyoxalase_6 PF18029.1 KPI85459.1 - 0.032 15.0 0.0 0.045 14.5 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain TPR_7 PF13176.6 KPI85459.1 - 0.082 13.0 0.0 0.22 11.6 0.0 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat DNA_pol_A_exo1 PF01612.20 KPI85461.1 - 2.1e-09 37.3 0.0 3.2e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease zf-CCHC PF00098.23 KPI85461.1 - 9.2e-07 28.7 29.9 0.0011 19.0 0.4 4.5 4 1 0 4 4 4 3 Zinc knuckle zf-C2H2_10 PF16588.5 KPI85461.1 - 3.9e-05 23.3 16.9 0.034 13.9 3.3 3.6 3 0 0 3 3 3 3 C2H2 zinc-finger zf-CCHC_6 PF15288.6 KPI85461.1 - 0.0076 16.1 1.3 0.0076 16.1 1.3 3.8 3 1 0 3 3 3 2 Zinc knuckle FA_desaturase_2 PF03405.14 KPI85461.1 - 0.19 10.5 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Fatty acid desaturase ADD_ATRX PF17981.1 KPI85461.1 - 0.23 11.3 5.3 0.22 11.4 3.6 1.8 1 1 0 1 1 1 0 Cysteine Rich ADD domain zinc_ribbon_4 PF13717.6 KPI85461.1 - 9.6 6.2 8.7 1 9.3 2.6 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DnaJ_C PF01556.18 KPI85462.1 - 1.3e-33 116.2 0.1 1.9e-33 115.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI85462.1 - 2.1e-21 75.8 0.9 3.7e-21 75.0 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KPI85462.1 - 8.5e-14 51.7 20.7 1.6e-13 50.8 20.7 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 KPI85462.1 - 0.097 12.7 7.2 3 7.9 1.0 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA tRNA_U5-meth_tr PF05958.11 KPI85463.1 - 0.0001 21.4 0.1 0.00018 20.6 0.1 1.3 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TPR_14 PF13428.6 KPI85464.1 - 0.00028 21.4 1.7 0.66 10.9 0.1 3.9 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85464.1 - 0.0094 16.1 0.4 1.6 9.1 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85464.1 - 0.011 16.2 2.9 0.039 14.5 1.2 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI85464.1 - 0.018 15.1 0.7 9.7 6.6 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI85464.1 - 0.032 14.9 1.7 0.05 14.3 0.5 2.0 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI85464.1 - 0.038 14.2 0.2 0.069 13.4 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Alpha_adaptin_C PF02296.16 KPI85464.1 - 0.043 14.0 0.0 0.78 9.9 0.0 2.2 2 0 0 2 2 2 0 Alpha adaptin AP2, C-terminal domain TPR_1 PF00515.28 KPI85464.1 - 0.093 12.6 2.3 4.7 7.2 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DENN PF02141.21 KPI85465.1 - 1.2e-23 84.0 0.6 2e-23 83.3 0.6 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain SPA PF08616.10 KPI85465.1 - 5.1e-05 23.2 0.5 9.7e-05 22.3 0.5 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis uDENN PF03456.18 KPI85465.1 - 0.011 16.4 0.0 0.028 15.2 0.0 1.7 1 0 0 1 1 1 0 uDENN domain PPR PF01535.20 KPI85466.1 - 1.7e-26 90.6 17.6 0.0067 16.6 0.1 12.4 12 0 0 12 12 12 5 PPR repeat PPR_2 PF13041.6 KPI85466.1 - 3.1e-23 81.7 8.4 4.9e-05 23.4 0.0 8.6 5 1 4 9 9 9 7 PPR repeat family PPR_3 PF13812.6 KPI85466.1 - 2.7e-12 46.5 10.7 0.009 16.1 0.0 7.5 6 1 0 7 7 7 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 KPI85466.1 - 3.3e-10 39.5 0.1 0.066 12.9 0.0 6.0 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 KPI85466.1 - 7.1e-07 28.8 21.1 8e-06 25.4 0.5 6.6 2 2 5 7 7 7 2 Pentacotripeptide-repeat region of PRORP ERAP1_C PF11838.8 KPI85466.1 - 0.00056 19.6 7.0 0.094 12.2 0.1 4.4 2 2 3 5 5 5 1 ERAP1-like C-terminal domain TPR_19 PF14559.6 KPI85466.1 - 0.012 16.1 1.1 13 6.4 0.3 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat SPOB_a PF14689.6 KPI85466.1 - 0.23 11.2 4.6 41 4.0 0.0 4.9 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain RhoGAP PF00620.27 KPI85466.1 - 0.46 10.3 4.3 32 4.3 0.0 4.2 4 1 0 4 4 4 0 RhoGAP domain Cupin_8 PF13621.6 KPI85467.1 - 2e-43 149.0 0.0 3e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.14 KPI85467.1 - 9.7e-12 45.2 0.1 2.4e-06 27.6 0.0 3.1 2 1 0 2 2 2 2 Leucine carboxyl methyltransferase Kelch_3 PF13415.6 KPI85467.1 - 1.3e-07 31.7 5.3 1.7e-05 25.0 0.1 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KPI85467.1 - 3.2e-05 23.8 0.0 3.7 7.6 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Cupin_4 PF08007.12 KPI85467.1 - 0.001 18.6 0.0 0.0022 17.5 0.0 1.5 1 1 0 1 1 1 1 Cupin superfamily protein Kelch_2 PF07646.15 KPI85467.1 - 0.016 15.2 2.4 3.2 7.9 0.0 4.5 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 KPI85467.1 - 0.017 15.4 0.1 4.8 7.6 0.0 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_4 PF13418.6 KPI85467.1 - 0.023 14.7 6.7 2.1 8.4 0.0 4.4 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF443 PF04276.12 KPI85468.1 - 0.0029 17.4 1.6 0.0029 17.4 1.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF443) GAS PF13851.6 KPI85469.1 - 0.0015 18.0 1.4 0.0035 16.7 1.4 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding UQ_con PF00179.26 KPI85470.1 - 0.066 12.9 0.0 0.5 10.0 0.0 2.2 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme SET PF00856.28 KPI85471.1 - 3.2e-11 43.9 0.0 2.2e-10 41.2 0.0 2.2 2 1 0 2 2 2 1 SET domain Beta_helix PF13229.6 KPI85472.1 - 0.026 14.4 0.4 0.05 13.4 0.4 1.4 1 0 0 1 1 1 0 Right handed beta helix region ParD_like PF11903.8 KPI85472.1 - 0.086 12.9 0.8 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 ParD-like antitoxin of type II bacterial toxin-antitoxin system PIH1 PF08190.12 KPI85473.1 - 4.3e-20 71.8 0.0 9.2e-09 35.0 0.0 3.4 3 0 0 3 3 3 3 PIH1 N-terminal domain PIH1_CS PF18201.1 KPI85473.1 - 1.6e-10 41.3 0.0 4.9e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 PIH1 CS-like domain Mito_carr PF00153.27 KPI85475.1 - 4.1e-30 103.5 7.9 5.9e-12 45.4 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Acetyltransf_1 PF00583.25 KPI85476.1 - 1.2e-09 38.4 0.0 6.8e-06 26.3 0.0 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI85476.1 - 1.3e-05 25.5 0.0 0.00039 20.8 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI85476.1 - 0.0038 17.2 0.0 0.088 12.8 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 KPI85476.1 - 0.0085 16.0 0.0 0.027 14.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Phytochelatin PF05023.14 KPI85477.1 - 0.0002 20.6 0.1 10 5.3 0.0 4.2 4 0 0 4 4 4 4 Phytochelatin synthase CDP-OH_P_transf PF01066.21 KPI85478.1 - 1.1e-17 64.5 0.1 1.1e-17 64.5 0.1 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CTP_transf_like PF01467.26 KPI85478.1 - 2.4e-15 57.0 0.0 4.2e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 KPI85478.1 - 0.084 12.8 0.0 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 FAD synthetase DUF4713 PF15831.5 KPI85478.1 - 0.32 11.5 6.1 5.8 7.4 3.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) YjgF_endoribonc PF14588.6 KPI85480.1 - 9.6e-33 113.4 0.1 1.1e-32 113.3 0.1 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 KPI85480.1 - 6.5e-21 74.6 0.0 8.2e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Vpu PF00558.19 KPI85481.1 - 0.98 9.2 4.2 0.67 9.8 1.9 1.8 1 1 1 2 2 2 0 Vpu protein K_channel_TID PF07941.11 KPI85481.1 - 2.8 8.4 6.7 0.22 12.0 1.1 1.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain PARG_cat PF05028.14 KPI85482.1 - 1.8e-51 175.4 0.0 2.4e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF4807 PF16065.5 KPI85483.1 - 0.0025 17.5 0.1 0.0044 16.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4807) Mt_ATP-synt_B PF05405.14 KPI85484.1 - 0.041 13.5 0.7 0.055 13.1 0.7 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF1319 PF07028.11 KPI85484.1 - 0.075 13.3 1.1 0.17 12.1 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) EzrA PF06160.12 KPI85484.1 - 0.2 9.8 1.9 0.25 9.5 1.9 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA FmiP_Thoc5 PF09766.9 KPI85484.1 - 0.97 8.7 4.3 1.2 8.3 4.3 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Malate_DH PF12434.8 KPI85484.1 - 9.1 6.4 9.1 1.5 8.9 4.0 2.4 2 0 0 2 2 2 0 Malate dehydrogenase enzyme cNMP_binding PF00027.29 KPI85485.1 - 0.00071 19.6 1.2 0.46 10.6 0.0 3.1 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 KPI85486.1 - 1.5e-12 46.5 13.4 0.074 13.1 0.0 9.5 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.7 KPI85486.1 - 0.56 10.7 11.0 19 5.8 0.0 5.5 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) Abhydrolase_6 PF12697.7 KPI85487.1 - 1.1e-14 55.6 0.9 1.6e-14 55.0 0.3 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KPI85487.1 - 5.8e-14 52.4 0.0 8.7e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI85487.1 - 2e-08 33.8 0.0 3.4e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 KPI85487.1 - 5.4e-06 26.4 0.0 1.5e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 Serine hydrolase LIDHydrolase PF10230.9 KPI85487.1 - 0.0015 18.1 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase ATP-synt_C PF00137.21 KPI85488.1 - 4.8e-27 94.1 34.9 1.6e-15 57.2 14.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF4064 PF13273.6 KPI85488.1 - 0.81 10.0 18.8 1.2 9.5 8.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) GerA PF03323.13 KPI85488.1 - 1.5 7.2 7.6 1.9 6.9 0.7 2.1 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Pro_isomerase PF00160.21 KPI85489.1 - 4e-12 46.7 0.0 5.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Beach PF02138.18 KPI85490.1 - 4.6e-99 331.3 0.0 6.7e-99 330.7 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain Laminin_G_3 PF13385.6 KPI85490.1 - 0.00014 22.1 0.0 0.00061 20.0 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily PH_BEACH PF14844.6 KPI85490.1 - 0.0039 17.3 0.0 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH NTP_transferase PF00483.23 KPI85491.1 - 1.5e-48 165.6 0.0 2.2e-48 165.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KPI85491.1 - 6.3e-12 46.1 0.0 1.2e-11 45.3 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 KPI85491.1 - 1e-09 37.7 19.2 4.8e-07 29.2 5.0 4.6 1 1 3 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 KPI85491.1 - 4.4e-06 25.9 0.2 3e-05 23.1 0.2 2.0 1 1 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 KPI85491.1 - 0.016 13.4 2.5 0.027 12.6 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 KPI85491.1 - 0.023 14.6 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase Methyltransf_16 PF10294.9 KPI85492.1 - 4.7e-15 55.7 0.0 6.3e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 KPI85492.1 - 3.4e-07 30.2 0.0 6e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI85492.1 - 2.9e-06 27.9 0.0 5.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI85492.1 - 5.7e-06 26.9 0.1 1.4e-05 25.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI85492.1 - 2.4e-05 24.0 0.1 3.9e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain tRNA_U5-meth_tr PF05958.11 KPI85492.1 - 0.00076 18.6 0.0 0.00092 18.3 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_9 PF08003.11 KPI85492.1 - 0.0011 18.0 0.0 0.0017 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 KPI85492.1 - 0.0039 16.6 0.1 0.0058 16.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 KPI85492.1 - 0.021 14.1 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KPI85492.1 - 0.041 13.7 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KPI85492.1 - 0.082 13.6 0.3 0.18 12.5 0.3 1.7 1 1 0 1 1 1 0 Methyltransferase domain MethyltransfD12 PF02086.15 KPI85492.1 - 0.14 11.8 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase RrnaAD PF00398.20 KPI85492.1 - 0.24 10.4 0.0 0.36 9.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RMI1_N PF08585.12 KPI85493.1 - 1.3e-25 90.5 0.6 7.7e-25 87.9 0.6 1.9 1 1 0 1 1 1 1 RecQ mediated genome instability protein Tropomyosin_1 PF12718.7 KPI85494.1 - 0.00022 21.4 9.5 0.00022 21.4 9.5 4.7 1 1 3 4 4 4 1 Tropomyosin like Colicin PF01024.19 KPI85494.1 - 7.6 6.4 14.8 3.5 7.5 4.0 2.9 2 1 1 3 3 3 0 Colicin pore forming domain Arginase PF00491.21 KPI85495.1 - 2.1e-28 99.6 0.0 2.5e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Arginase family Pro_isomerase PF00160.21 KPI85497.1 - 3.3e-46 157.4 0.0 4.7e-46 157.0 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med3 PF11593.8 KPI85497.1 - 3.9 6.6 4.6 5.2 6.2 4.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal AhpC-TSA PF00578.21 KPI85498.1 - 1.3e-38 131.8 0.0 1.6e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KPI85498.1 - 2.1e-15 56.7 0.0 2.8e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 KPI85498.1 - 1.2e-08 34.6 0.0 2.7e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 KPI85498.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.5 1 1 0 1 1 1 0 AhpC/TSA antioxidant enzyme UTP15_C PF09384.10 KPI85499.1 - 5.5e-31 107.2 0.2 8.4e-31 106.6 0.2 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 KPI85499.1 - 1.9e-15 56.9 7.1 0.00042 21.1 0.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Lgl_C PF08596.10 KPI85499.1 - 0.016 13.9 0.1 0.027 13.2 0.1 1.2 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal P34-Arc PF04045.14 KPI85499.1 - 0.018 14.7 0.6 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 Arp2/3 complex, 34 kD subunit p34-Arc Ribosomal_L19 PF01245.20 KPI85500.1 - 0.078 12.9 0.1 0.34 10.9 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L19 DUF1216 PF06746.11 KPI85501.1 - 0.019 14.9 2.3 0.022 14.8 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) Hpt PF01627.23 KPI85501.1 - 0.056 13.7 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Hpt domain Kelch_5 PF13854.6 KPI85505.1 - 3.2e-23 81.3 5.3 2.1e-05 24.4 0.0 5.8 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 KPI85505.1 - 2.7e-20 71.7 14.6 0.00029 20.4 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KPI85505.1 - 2.4e-17 62.5 15.6 4.9e-06 26.6 0.1 6.4 5 2 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KPI85505.1 - 3.9e-17 62.1 11.5 0.00063 20.0 0.0 6.3 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.6 KPI85505.1 - 2.1e-14 53.2 6.2 0.0091 16.0 0.1 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KPI85505.1 - 2.7e-06 27.1 21.5 1.4 9.0 0.1 6.9 6 2 0 6 6 6 4 Kelch motif GST_C_2 PF13410.6 KPI85506.1 - 2.8 8.1 5.9 4.5 7.4 0.1 3.4 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain AA_kinase PF00696.28 KPI85507.1 - 0.16 11.5 0.4 5.7 6.5 0.0 2.1 1 1 1 2 2 2 0 Amino acid kinase family DS PF01916.17 KPI85509.1 - 3.4e-87 292.4 0.0 4.1e-87 292.1 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase AAA_5 PF07728.14 KPI85510.1 - 4.7e-123 405.6 0.0 1.2e-23 83.6 0.0 8.9 9 0 0 9 9 8 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 KPI85510.1 - 1.3e-45 154.0 3.5 1.1e-13 51.2 0.5 5.3 4 0 0 4 4 4 4 Midasin AAA lid domain AAA_3 PF07726.11 KPI85510.1 - 1.8e-26 92.5 0.0 0.0007 19.5 0.0 8.4 8 0 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KPI85510.1 - 5.3e-24 84.7 0.2 0.00018 21.0 0.0 6.5 6 0 0 6 6 6 6 P-loop containing dynein motor region AAA_lid_5 PF17865.1 KPI85510.1 - 3e-22 78.7 0.0 1.3e-21 76.7 0.0 2.2 2 0 0 2 2 1 1 Midasin AAA lid domain AAA PF00004.29 KPI85510.1 - 8.3e-21 74.8 0.7 0.0049 17.3 0.0 7.6 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI85510.1 - 1.3e-20 74.1 0.0 0.0023 18.2 0.0 7.3 6 0 0 6 6 6 5 AAA domain AAA_16 PF13191.6 KPI85510.1 - 1.5e-20 74.3 16.0 0.00026 21.4 0.0 9.7 8 1 0 8 8 6 5 AAA ATPase domain AAA_6 PF12774.7 KPI85510.1 - 1.2e-19 70.4 0.0 0.12 11.3 0.0 8.5 9 1 0 9 9 9 5 Hydrolytic ATP binding site of dynein motor region Dynein_heavy PF03028.15 KPI85510.1 - 1.5e-17 63.8 0.0 0.006 16.7 0.0 6.1 5 0 0 5 5 5 3 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 KPI85510.1 - 5.9e-15 55.4 0.0 0.021 14.5 0.0 6.4 6 0 0 6 6 6 2 Sigma-54 interaction domain TsaE PF02367.17 KPI85510.1 - 4.1e-13 49.4 1.9 0.031 14.3 0.0 6.6 6 0 0 6 6 6 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KPI85510.1 - 8.1e-12 45.8 1.2 0.19 12.2 0.0 6.9 6 0 0 6 6 6 2 ABC transporter AAA_14 PF13173.6 KPI85510.1 - 1.2e-11 44.8 0.0 0.014 15.4 0.0 6.6 6 0 0 6 6 6 2 AAA domain Sigma54_activ_2 PF14532.6 KPI85510.1 - 5e-10 39.6 0.2 0.0036 17.4 0.0 5.7 6 0 0 6 6 5 2 Sigma-54 interaction domain AAA_18 PF13238.6 KPI85510.1 - 4e-09 37.1 0.9 1 9.9 0.0 7.0 7 1 0 7 7 6 2 AAA domain AAA_29 PF13555.6 KPI85510.1 - 2.1e-08 33.8 0.8 11 5.8 0.0 6.4 6 0 0 6 6 6 0 P-loop containing region of AAA domain Rad17 PF03215.15 KPI85510.1 - 4.8e-08 33.2 2.6 2.6 7.9 0.0 6.4 7 0 0 7 7 6 1 Rad17 P-loop domain AAA_25 PF13481.6 KPI85510.1 - 1.9e-07 30.9 11.4 0.14 11.7 0.0 7.3 8 0 0 8 8 6 1 AAA domain AAA_33 PF13671.6 KPI85510.1 - 2.9e-07 30.7 1.2 16 5.6 0.0 7.1 7 0 0 7 7 7 0 AAA domain IstB_IS21 PF01695.17 KPI85510.1 - 2.9e-07 30.4 0.9 0.56 9.9 0.0 4.7 5 0 0 5 5 3 2 IstB-like ATP binding protein DUF815 PF05673.13 KPI85510.1 - 3.1e-07 29.8 1.3 0.34 10.0 0.0 5.1 5 0 0 5 5 5 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KPI85510.1 - 4.6e-07 30.2 0.3 0.53 10.7 0.0 6.3 7 0 0 7 7 5 1 RNA helicase RsgA_GTPase PF03193.16 KPI85510.1 - 1.1e-06 28.7 5.2 1.9 8.4 0.0 6.6 6 0 0 6 6 6 1 RsgA GTPase T2SSE PF00437.20 KPI85510.1 - 2.2e-06 26.9 0.8 0.62 9.1 0.0 5.7 6 0 0 6 6 6 1 Type II/IV secretion system protein AAA_8 PF12780.7 KPI85510.1 - 4.5e-06 26.2 0.1 0.72 9.1 0.0 4.7 5 0 0 5 5 4 2 P-loop containing dynein motor region D4 RuvB_N PF05496.12 KPI85510.1 - 2.2e-05 24.3 0.6 1 9.1 0.0 5.0 6 0 0 6 6 5 1 Holliday junction DNA helicase RuvB P-loop domain CPT PF07931.12 KPI85510.1 - 0.00015 21.7 0.3 0.91 9.3 0.0 4.4 4 0 0 4 4 4 1 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 KPI85510.1 - 0.00016 21.6 5.0 2.1 8.3 0.0 6.3 7 0 0 7 7 7 1 NACHT domain NTPase_1 PF03266.15 KPI85510.1 - 0.00075 19.5 0.3 1.6 8.6 0.1 4.3 4 0 0 4 4 3 1 NTPase dNK PF01712.19 KPI85510.1 - 0.0024 17.8 0.4 19 5.0 0.0 4.2 4 0 0 4 4 4 0 Deoxynucleoside kinase DAP3 PF10236.9 KPI85510.1 - 0.0033 16.7 0.0 3.1 6.9 0.0 3.5 3 0 0 3 3 3 1 Mitochondrial ribosomal death-associated protein 3 TniB PF05621.11 KPI85510.1 - 0.018 14.4 0.0 5.8 6.3 0.0 4.4 5 0 0 5 5 5 0 Bacterial TniB protein ResIII PF04851.15 KPI85510.1 - 0.043 13.8 4.9 2.9 7.9 0.0 4.6 5 0 0 5 5 4 0 Type III restriction enzyme, res subunit DUF2385 PF09539.10 KPI85510.1 - 0.076 13.6 0.1 0.49 10.9 0.0 2.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2385) PduV-EutP PF10662.9 KPI85510.1 - 0.13 12.0 0.4 47 3.7 0.0 4.0 5 0 0 5 5 3 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 KPI85510.1 - 0.19 11.2 4.3 6 6.3 0.1 3.9 5 0 0 5 5 3 0 PhoH-like protein AAA_19 PF13245.6 KPI85510.1 - 0.28 11.5 12.9 18 5.7 0.0 6.8 8 0 0 8 8 5 0 AAA domain Roc PF08477.13 KPI85510.1 - 0.36 11.0 1.3 63 3.8 0.0 4.3 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 KPI85510.1 - 0.43 10.7 1.5 2.1 8.4 0.0 3.1 2 0 0 2 2 1 0 Helicase HerA, central domain MeaB PF03308.16 KPI85510.1 - 0.98 8.3 7.1 6.9 5.6 0.0 3.7 4 0 0 4 4 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Enkurin PF13864.6 KPI85511.1 - 3.1e-17 62.8 0.9 4.7e-17 62.2 0.9 1.3 1 0 0 1 1 1 1 Calmodulin-binding DUF2730 PF10805.8 KPI85511.1 - 0.099 12.7 0.4 0.2 11.7 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) HATPase_c PF02518.26 KPI85512.1 - 1.3e-10 41.7 0.0 3.3e-10 40.5 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KPI85512.1 - 1.5e-05 24.9 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ZZ PF00569.17 KPI85513.1 - 4.3e-06 26.4 11.1 4.3e-06 26.4 11.1 2.6 2 0 0 2 2 2 1 Zinc finger, ZZ type LRR_6 PF13516.6 KPI85514.1 - 0.0089 16.0 2.9 1.2 9.4 0.1 3.7 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 KPI85514.1 - 0.17 12.4 1.6 35 5.0 0.0 3.6 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) DSPn PF14671.6 KPI85515.1 - 0.1 13.0 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half LRR_4 PF12799.7 KPI85516.1 - 4.5e-13 49.2 20.2 3.6e-06 27.2 2.9 5.9 5 2 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85516.1 - 8.4e-12 44.7 10.8 0.00011 21.9 0.5 3.8 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 KPI85516.1 - 8.8e-06 25.6 16.1 0.91 10.3 0.1 7.5 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 KPI85516.1 - 0.0001 22.1 15.9 0.33 11.1 0.3 7.2 7 0 0 7 7 7 1 Leucine Rich repeat DUF1599 PF07659.11 KPI85516.1 - 0.12 12.8 0.0 0.37 11.3 0.0 1.8 1 0 0 1 1 1 0 Nucleotide modification associated domain 1 LRR_9 PF14580.6 KPI85516.1 - 0.18 11.3 1.3 2.2 7.8 0.1 2.9 3 0 0 3 3 3 0 Leucine-rich repeat zf-C3HC4_3 PF13920.6 KPI85518.1 - 8.4 6.4 11.8 19 5.2 11.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Acetyltransf_13 PF13880.6 KPI85519.1 - 1.3e-20 73.2 0.0 2.6e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Proteasome PF00227.26 KPI85521.1 - 7.4e-57 191.9 0.1 9.6e-57 191.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI85521.1 - 1.5e-14 53.3 0.2 2.7e-14 52.5 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Styelin PF17562.2 KPI85521.1 - 0.029 14.7 3.2 0.27 11.6 1.8 2.3 2 0 0 2 2 2 0 Styelin Rad51 PF08423.11 KPI85522.1 - 4.2e-16 59.0 0.0 8.4e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 KPI85522.1 - 2.1e-05 24.1 0.1 0.00013 21.5 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 KPI85522.1 - 3.1e-05 23.5 0.9 0.00091 18.6 0.9 2.1 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 KPI85522.1 - 4.6e-05 23.1 2.8 0.00015 21.4 2.8 1.8 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 KPI85522.1 - 0.00059 19.3 0.0 0.006 15.9 0.0 2.0 2 0 0 2 2 2 1 KaiC PP2C_2 PF13672.6 KPI85522.1 - 0.027 14.1 0.2 0.052 13.2 0.2 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C AAA_16 PF13191.6 KPI85522.1 - 0.039 14.4 0.3 0.096 13.1 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KPI85522.1 - 0.059 13.1 0.2 0.46 10.2 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KPI85522.1 - 0.15 12.3 0.1 0.36 11.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 KPI85522.1 - 0.17 12.1 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pterin_4a PF01329.19 KPI85523.1 - 3.4e-26 91.2 0.0 4.1e-26 91.0 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Sec16 PF12932.7 KPI85524.1 - 0.0011 19.5 0.2 0.0012 19.4 0.2 1.1 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region HAP1_N PF04849.13 KPI85524.1 - 0.0011 18.2 1.1 0.0011 18.2 1.1 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region APG6_N PF17675.1 KPI85524.1 - 0.014 15.9 6.0 0.015 15.8 6.0 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region Mei5 PF10376.9 KPI85524.1 - 0.017 15.0 1.4 0.017 15.0 1.4 1.0 1 0 0 1 1 1 0 Double-strand recombination repair protein CCDC106 PF15794.5 KPI85524.1 - 0.028 14.2 1.9 0.028 14.1 1.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Ax_dynein_light PF10211.9 KPI85524.1 - 0.031 14.2 3.9 0.034 14.1 3.9 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain MerR-DNA-bind PF09278.11 KPI85524.1 - 0.041 14.4 5.2 0.041 14.4 5.2 1.6 1 1 1 2 2 2 0 MerR, DNA binding IF-2B PF01008.17 KPI85524.1 - 0.052 12.7 0.2 0.054 12.7 0.2 1.0 1 0 0 1 1 1 0 Initiation factor 2 subunit family DUF4337 PF14235.6 KPI85524.1 - 0.059 13.5 2.9 0.068 13.3 2.8 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) NUDE_C PF04880.13 KPI85524.1 - 4.8 7.6 10.3 0.56 10.7 4.9 1.8 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region Pyrophosphatase PF00719.19 KPI85525.1 - 5.1e-46 156.4 0.1 7.7e-46 155.8 0.1 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase EF-hand_7 PF13499.6 KPI85525.1 - 0.06 13.8 0.1 0.27 11.7 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain pair Asparaginase_II PF06089.12 KPI85526.1 - 0.06 12.4 2.5 0.041 12.9 0.4 1.7 1 1 0 2 2 2 0 L-asparaginase II SOAR PF16533.5 KPI85526.1 - 0.062 13.3 0.8 0.13 12.3 0.4 1.7 1 1 1 2 2 2 0 STIM1 Orai1-activating region Baculo_PEP_C PF04513.12 KPI85526.1 - 1.7 8.7 6.5 8.2 6.5 3.7 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LRR_6 PF13516.6 KPI85527.1 - 1.2e-06 28.1 0.9 0.0013 18.6 0.0 4.1 4 0 0 4 4 4 1 Leucine Rich repeat LRR_4 PF12799.7 KPI85527.1 - 0.019 15.4 0.0 1.3 9.5 0.0 2.7 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) zf-nanos PF05741.13 KPI85527.1 - 0.12 12.7 0.3 0.28 11.4 0.3 1.6 1 0 0 1 1 1 0 Nanos RNA binding domain DEAD PF00270.29 KPI85528.1 - 3.1e-23 82.5 0.1 5e-23 81.8 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KPI85528.1 - 8e-07 29.2 0.0 1.8e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI85528.1 - 8.8e-06 26.0 0.1 0.00012 22.3 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PhoH PF02562.16 KPI85528.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Pre-PUA PF17832.1 KPI85529.1 - 1.4e-19 70.5 0.4 2.1e-19 70.0 0.4 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 KPI85529.1 - 3.5e-13 49.3 0.6 5.7e-13 48.6 0.6 1.4 1 0 0 1 1 1 1 PUA domain Orbi_VP5 PF00901.17 KPI85529.1 - 0.14 10.6 0.0 0.16 10.3 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 3-PAP PF12578.8 KPI85530.1 - 2e-09 37.3 1.3 2e-09 37.3 1.3 2.5 2 0 0 2 2 2 1 Myotubularin-associated protein Dzip-like_N PF13815.6 KPI85530.1 - 1.2e-05 25.3 0.2 1.2e-05 25.3 0.2 2.5 3 0 0 3 3 3 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal zf-Mss51 PF13824.6 KPI85530.1 - 0.067 13.3 0.4 0.35 11.0 0.1 2.4 3 0 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Sec15 PF04091.12 KPI85531.1 - 0.0033 16.9 0.1 0.0073 15.8 0.1 1.5 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like PSP1 PF04468.12 KPI85533.1 - 5.7e-28 97.0 0.2 8.8e-28 96.4 0.2 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region NIF3 PF01784.18 KPI85534.1 - 1.4e-66 224.6 0.0 1.7e-66 224.3 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ScdA_N PF04405.14 KPI85535.1 - 0.11 12.2 0.1 0.25 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) Pkinase PF00069.25 KPI85536.1 - 7.4e-47 159.9 0.0 9.7e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85536.1 - 5.9e-22 78.2 0.0 8.2e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI85536.1 - 0.00041 20.3 2.3 0.0012 18.8 0.6 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI85536.1 - 0.0015 17.5 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KPI85536.1 - 0.0024 17.2 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 KPI85536.1 - 0.0035 16.4 0.1 0.0053 15.8 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 KPI85536.1 - 0.043 13.2 0.5 0.14 11.5 0.1 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI85536.1 - 0.17 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family tRNA-synt_2b PF00587.25 KPI85537.1 - 4.6e-32 111.4 0.0 8.1e-32 110.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KPI85537.1 - 2.2e-15 56.8 2.9 1.8e-13 50.7 0.3 2.3 1 1 1 2 2 2 2 Seryl-tRNA synthetase N-terminal domain MORN PF02493.20 KPI85538.1 - 1.1e-33 113.0 48.6 1.4e-05 24.6 1.3 9.4 9 0 0 9 9 9 9 MORN repeat Pertussis_S1 PF02917.14 KPI85538.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin, subunit 1 RRM_1 PF00076.22 KPI85539.1 - 0.0013 18.5 0.1 0.011 15.6 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRIP PF01465.20 KPI85540.1 - 2.2e-10 40.2 0.0 4e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 GRIP domain Cnn_1N PF07989.11 KPI85540.1 - 0.024 14.8 1.6 0.024 14.8 1.6 3.4 4 0 0 4 4 4 0 Centrosomin N-terminal motif 1 APC_N_CC PF16689.5 KPI85540.1 - 0.11 12.5 0.4 0.11 12.5 0.4 3.8 4 2 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain YabA PF06156.13 KPI85540.1 - 0.83 10.3 11.4 1.2 9.8 0.6 3.3 3 1 0 3 3 3 0 Initiation control protein YabA Fez1 PF06818.15 KPI85540.1 - 1.2 9.6 13.3 0.077 13.4 3.4 2.8 3 0 0 3 3 3 0 Fez1 Shugoshin_N PF07558.11 KPI85540.1 - 4.6 7.2 12.6 17 5.4 0.1 4.6 4 1 0 4 4 4 0 Shugoshin N-terminal coiled-coil region LRR_4 PF12799.7 KPI85541.1 - 3.4e-23 81.3 37.7 0.0091 16.4 0.0 11.7 8 4 5 13 13 13 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85541.1 - 9.8e-13 47.7 38.8 0.00079 19.1 1.2 9.9 6 3 7 13 13 13 9 Leucine rich repeat LRR_9 PF14580.6 KPI85541.1 - 2.9e-05 23.6 13.3 0.12 11.8 0.0 5.1 4 2 1 5 5 5 2 Leucine-rich repeat LRR_6 PF13516.6 KPI85541.1 - 8.9e-05 22.2 35.2 1.3 9.3 0.3 12.2 14 0 0 14 14 14 2 Leucine Rich repeat LRR_2 PF07723.13 KPI85541.1 - 0.81 10.5 3.1 5.7 7.8 1.3 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat RNA_pol_Rpb1_5 PF04998.17 KPI85543.1 - 1.4e-57 195.2 0.0 5.9e-57 193.1 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KPI85543.1 - 5.4e-49 166.6 0.0 9.4e-49 165.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KPI85543.1 - 5.7e-31 107.6 0.0 1.2e-30 106.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KPI85543.1 - 1.1e-15 57.5 0.5 8.4e-15 54.6 0.3 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 TFIIF_alpha PF05793.12 KPI85543.1 - 0.14 10.7 13.7 0.24 9.9 13.7 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNA_pol_Rpb1_1 PF04997.12 KPI85543.1 - 0.21 10.9 0.1 0.95 8.7 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 1 NAM-associated PF14303.6 KPI85543.1 - 0.54 11.0 7.9 1.5 9.5 7.9 1.7 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Nop14 PF04147.12 KPI85543.1 - 0.88 7.7 18.9 1.4 7.0 18.9 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KPI85543.1 - 6.8 6.0 22.6 28 4.0 18.5 2.2 2 0 0 2 2 2 0 SDA1 Amidase PF01425.21 KPI85544.1 - 5.7e-62 210.1 0.0 4.3e-55 187.5 0.0 2.1 2 0 0 2 2 2 2 Amidase LSM PF01423.22 KPI85545.1 - 9.2e-06 25.3 0.0 1.2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 KPI85545.1 - 0.015 15.2 0.2 0.021 14.7 0.2 1.3 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Arf PF00025.21 KPI85546.1 - 3.7e-49 166.5 0.0 4.1e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI85546.1 - 4.5e-12 46.2 0.1 6.1e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI85546.1 - 8.5e-11 41.6 0.0 1.1e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KPI85546.1 - 1.5e-09 37.7 0.0 1.7e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 KPI85546.1 - 5.6e-09 35.8 0.1 1.2e-08 34.7 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI85546.1 - 7.9e-09 35.6 0.0 1.2e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KPI85546.1 - 1.9e-08 33.9 2.1 0.00018 20.8 0.3 2.8 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KPI85546.1 - 3.2e-07 29.9 0.1 4e-07 29.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KPI85546.1 - 0.00013 21.6 0.1 0.00035 20.1 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 KPI85546.1 - 0.0011 19.5 0.0 0.0029 18.1 0.0 1.7 1 1 1 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KPI85546.1 - 0.0013 18.7 0.0 1.4 8.8 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KPI85546.1 - 0.004 17.4 0.0 0.018 15.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 KPI85546.1 - 0.031 13.9 0.0 2.9 7.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain OTU PF02338.19 KPI85547.1 - 4.2e-14 53.1 0.0 7.5e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease EMG1 PF03587.14 KPI85548.1 - 6.9e-56 189.0 0.0 1.5e-55 187.9 0.0 1.5 1 1 0 1 1 1 1 EMG1/NEP1 methyltransferase HTH_18 PF12833.7 KPI85548.1 - 0.081 13.2 0.1 16 5.9 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain TRAPP PF04051.16 KPI85549.1 - 1.3e-21 76.8 0.0 1.7e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component MYO10_CC PF16735.5 KPI85550.1 - 0.045 13.9 0.6 0.045 13.9 0.6 3.9 3 1 1 4 4 4 0 Unconventional myosin-X coiled coil domain IQ PF00612.27 KPI85550.1 - 0.054 13.3 2.5 0.19 11.6 2.5 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Siah-Interact_N PF09032.11 KPI85550.1 - 0.24 11.8 5.2 2.3 8.6 1.9 3.2 2 0 0 2 2 2 0 Siah interacting protein, N terminal IFP_35_N PF07334.13 KPI85550.1 - 0.45 10.6 7.1 0.54 10.4 1.7 2.6 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Prefoldin PF02996.17 KPI85550.1 - 4.3 7.3 13.7 0.85 9.5 2.9 3.2 3 0 0 3 3 3 0 Prefoldin subunit DUF572 PF04502.13 KPI85551.1 - 0.16 11.6 7.5 0.016 14.8 3.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF572) RSN1_7TM PF02714.15 KPI85552.1 - 4.7e-22 78.6 12.4 9.1e-22 77.7 12.4 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate Pro_isomerase PF00160.21 KPI85553.1 - 1e-30 107.1 0.0 1.8e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD dsrm PF00035.26 KPI85554.1 - 2.6e-05 24.8 0.0 0.0018 19.0 0.0 3.4 3 0 0 3 3 3 1 Double-stranded RNA binding motif Cullin PF00888.22 KPI85555.1 - 7.9e-44 150.3 0.0 1.5e-35 123.0 0.0 3.6 4 0 0 4 4 4 3 Cullin family Cullin_Nedd8 PF10557.9 KPI85555.1 - 7.3e-17 61.2 0.0 1.5e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Cullin protein neddylation domain LSM PF01423.22 KPI85558.1 - 1.1e-05 25.0 0.0 2.8e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 LSM domain HSP90 PF00183.18 KPI85559.1 - 0.12 11.2 0.3 0.22 10.4 0.3 1.3 1 0 0 1 1 1 0 Hsp90 protein PI-PLC-X PF00388.19 KPI85561.1 - 7.1e-60 200.8 0.0 2.1e-59 199.3 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KPI85561.1 - 2.6e-33 114.8 0.0 5.5e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KPI85561.1 - 1.1e-10 41.7 0.0 2.3e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 KPI85561.1 - 1.5e-06 28.5 0.0 5.9e-06 26.6 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI85561.1 - 0.00015 21.1 0.1 0.026 14.1 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KPI85561.1 - 0.0017 18.1 0.0 1.3 9.1 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain Amastin PF07344.11 KPI85563.1 - 8.8e-21 74.4 10.6 1.6e-20 73.6 10.6 1.4 1 1 0 1 1 1 1 Amastin surface glycoprotein MARVEL PF01284.23 KPI85563.1 - 6.7e-07 29.4 20.3 5.5e-05 23.2 13.2 2.6 1 1 1 2 2 2 2 Membrane-associating domain SUR7 PF06687.12 KPI85563.1 - 2 8.0 14.8 2.1 7.9 0.2 2.3 2 1 0 2 2 2 0 SUR7/PalI family VMA21 PF09446.10 KPI85563.1 - 8.4 6.6 15.3 0.58 10.3 0.6 3.2 3 1 0 3 3 3 0 VMA21-like domain RINT1_TIP1 PF04437.13 KPI85564.1 - 4.4e-05 22.6 0.0 7.5e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 RINT-1 / TIP-1 family TipAS PF07739.13 KPI85564.1 - 0.023 15.2 1.7 0.14 12.7 0.5 2.4 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain CAF1 PF04857.20 KPI85566.1 - 5.4e-18 65.2 5.1 6.9e-09 35.3 0.1 2.8 1 1 1 2 2 2 2 CAF1 family ribonuclease ASH PF15780.5 KPI85567.1 - 3.3e-27 94.6 27.8 0.00053 20.2 0.0 15.8 17 0 0 17 17 17 9 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 KPI85567.1 - 1.2e-09 38.3 10.6 0.12 12.6 0.2 10.1 11 0 0 11 11 11 1 Transmembrane protein 131-like PapD-like PF14874.6 KPI85567.1 - 1.5e-08 34.7 10.6 0.0031 17.6 0.1 6.5 5 1 1 6 6 6 3 Flagellar-associated PapD-like Motile_Sperm PF00635.26 KPI85567.1 - 1.8e-05 24.6 0.3 13 5.7 0.0 7.9 9 0 0 9 9 9 1 MSP (Major sperm protein) domain DUF5001 PF16392.5 KPI85567.1 - 0.00017 21.4 0.2 2.3 8.2 0.0 5.6 5 0 0 5 5 5 1 Ig-like domain Glyco_hydro_30C PF17189.4 KPI85567.1 - 0.75 10.0 3.1 75 3.7 0.0 4.6 4 0 0 4 4 4 0 Glycosyl hydrolase family 30 beta sandwich domain NOG1 PF06858.14 KPI85568.1 - 0.17 11.7 0.2 0.69 9.7 0.1 2.1 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) Metallophos PF00149.28 KPI85569.1 - 2.4e-10 41.2 0.0 4.3e-10 40.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KPI85569.1 - 5.4e-06 26.7 0.0 1.1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DNA_ligase_IV PF11411.8 KPI85570.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 DNA ligase IV RNase_PH PF01138.21 KPI85571.1 - 2e-09 38.0 0.0 4.8e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KPI85571.1 - 0.00025 21.0 0.1 0.00049 20.1 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 PID_2 PF14719.6 KPI85573.1 - 0.028 14.3 0.0 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Amastin PF07344.11 KPI85574.1 - 7.6e-39 133.0 7.9 9.5e-39 132.7 7.9 1.0 1 0 0 1 1 1 1 Amastin surface glycoprotein Amastin PF07344.11 KPI85575.1 - 6.9e-54 181.9 7.9 8.4e-54 181.6 7.9 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein PMP22_Claudin PF00822.20 KPI85575.1 - 0.00063 19.7 4.8 0.00063 19.7 4.8 2.1 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KPI85575.1 - 0.00089 19.1 1.3 0.00089 19.1 1.3 2.0 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction SUR7 PF06687.12 KPI85575.1 - 0.041 13.5 26.2 8.8 5.9 0.4 3.2 2 1 0 2 2 2 0 SUR7/PalI family Phage_holin_2_3 PF16080.5 KPI85575.1 - 0.068 12.9 0.6 0.068 12.9 0.6 2.1 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Shisa PF13908.6 KPI85575.1 - 0.084 13.1 0.5 0.14 12.4 0.5 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator NicO PF03824.16 KPI85575.1 - 0.79 9.0 4.8 0.098 12.0 0.5 1.7 2 0 0 2 2 2 0 High-affinity nickel-transport protein DUF4131 PF13567.6 KPI85575.1 - 0.88 9.2 4.4 0.18 11.4 0.7 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4064 PF13273.6 KPI85575.1 - 3.7 7.9 15.3 0.66 10.3 0.2 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Amastin PF07344.11 KPI85576.1 - 4.4e-25 88.3 0.0 5.1e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein Amastin PF07344.11 KPI85577.1 - 2e-44 151.2 13.6 2.3e-44 151.0 13.6 1.0 1 0 0 1 1 1 1 Amastin surface glycoprotein Ion_trans PF00520.31 KPI85577.1 - 0.0063 15.8 5.4 0.0073 15.6 5.4 1.1 1 0 0 1 1 1 1 Ion transport protein Cdd1 PF11731.8 KPI85577.1 - 0.058 13.6 0.9 0.16 12.3 0.9 1.6 1 0 0 1 1 1 0 Pathogenicity locus Amastin PF07344.11 KPI85579.1 - 2.2e-24 86.1 0.8 2.3e-24 86.0 0.8 1.0 1 0 0 1 1 1 1 Amastin surface glycoprotein AAA_16 PF13191.6 KPI85580.1 - 6.6e-06 26.6 0.0 2.3e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KPI85580.1 - 0.013 15.8 0.0 0.044 14.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 KPI85580.1 - 0.037 14.0 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 KPI85580.1 - 0.078 13.1 1.0 1.4 9.1 0.0 2.7 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 KPI85580.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 KPI85580.1 - 0.18 12.4 0.0 0.53 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KPI85581.1 - 7.1e-06 26.5 0.0 2.3e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI85581.1 - 0.0034 17.6 0.1 0.028 14.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI85581.1 - 0.017 15.6 0.1 0.063 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 KPI85581.1 - 0.062 13.2 0.0 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 KPI85581.1 - 0.067 12.5 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin FAM199X PF15814.5 KPI85581.1 - 0.12 11.4 2.9 0.25 10.4 2.9 1.4 1 0 0 1 1 1 0 Protein family FAM199X Glutaredoxin PF00462.24 KPI85581.1 - 0.14 12.4 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin DUF2407_C PF13373.6 KPI85581.1 - 0.16 12.1 0.1 0.43 10.7 0.0 1.7 2 0 0 2 2 2 0 DUF2407 C-terminal domain AAA_16 PF13191.6 KPI85582.1 - 2.4e-05 24.8 0.0 5.7e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI85582.1 - 0.0029 17.9 0.0 0.0092 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KPI85582.1 - 0.0034 17.4 0.0 0.0065 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 KPI85582.1 - 0.0055 15.9 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 KPI85582.1 - 0.034 14.0 0.0 0.076 12.9 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 KPI85582.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 KPI85582.1 - 0.088 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 KPI85582.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 KPI85583.1 - 1.7e-07 31.8 0.6 4.5e-07 30.4 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KPI85583.1 - 3.6e-05 24.0 0.0 0.00012 22.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KPI85583.1 - 0.0029 16.7 0.0 0.0051 15.9 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 KPI85583.1 - 0.0041 17.3 0.0 0.012 15.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KPI85583.1 - 0.02 14.4 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 KPI85583.1 - 0.022 14.1 0.0 0.057 12.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 KPI85583.1 - 0.041 14.3 0.2 2.5 8.5 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 KPI85583.1 - 0.066 13.1 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_18 PF13238.6 KPI85583.1 - 0.072 13.6 0.3 0.24 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 KPI85583.1 - 0.089 12.7 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 KPI85583.1 - 0.099 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rhodanese PF00581.20 KPI85584.1 - 2.8e-07 31.0 0.0 0.051 14.1 0.0 3.5 3 0 0 3 3 3 3 Rhodanese-like domain Pkinase PF00069.25 KPI85585.1 - 3.5e-44 151.2 0.0 5.6e-32 111.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85585.1 - 1.5e-21 76.9 0.0 3.9e-15 55.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KPI85585.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-Tim10_DDP PF02953.15 KPI85586.1 - 0.099 12.3 0.0 0.099 12.3 0.0 1.8 2 0 0 2 2 2 0 Tim10/DDP family zinc finger Sugarporin_N PF11471.8 KPI85587.1 - 0.14 12.2 1.4 15 5.7 0.3 2.6 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension UQ_con PF00179.26 KPI85589.1 - 7.4e-16 58.1 0.0 1.2e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Zip PF02535.22 KPI85589.1 - 0.42 9.8 6.6 0.82 8.8 6.6 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter RAP1 PF07218.11 KPI85589.1 - 1.8 6.7 6.5 2.2 6.5 6.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RNA_pol_Rpb6 PF01192.22 KPI85590.1 - 7.9e-14 51.3 1.1 1.3e-13 50.6 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb6 DUF2169 PF09937.9 KPI85590.1 - 0.0075 15.8 0.0 0.0085 15.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2169) HTH_Tnp_ISL3 PF13542.6 KPI85591.1 - 0.023 14.1 0.5 0.32 10.4 0.0 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 2_5_RNA_ligase2 PF13563.6 KPI85593.1 - 0.0033 17.3 0.0 0.0064 16.4 0.0 1.5 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily MtN3_slv PF03083.16 KPI85594.1 - 5.7e-28 96.8 19.9 1.4e-17 63.5 1.7 2.6 2 1 0 2 2 2 2 Sugar efflux transporter for intercellular exchange PQ-loop PF04193.14 KPI85594.1 - 0.023 14.5 0.0 0.023 14.5 0.0 4.0 5 1 0 5 5 5 0 PQ loop repeat Rhomboid PF01694.22 KPI85594.1 - 0.39 10.7 9.7 0.8 9.7 9.7 1.5 1 0 0 1 1 1 0 Rhomboid family DUF3377 PF11857.8 KPI85594.1 - 3.7 7.6 7.6 0.9 9.5 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) DUF2070 PF09843.9 KPI85594.1 - 5.2 5.2 13.5 6.5 4.9 13.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) LRR_4 PF12799.7 KPI85595.1 - 1.3e-20 73.2 8.5 1.7e-08 34.6 1.2 4.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI85595.1 - 4.3e-14 52.4 0.1 4.4e-10 39.3 0.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KPI85595.1 - 2.4e-10 40.0 16.1 5.9e-05 22.7 2.8 4.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 KPI85595.1 - 0.0014 18.5 8.2 0.92 9.7 0.1 4.6 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 KPI85595.1 - 0.066 13.8 9.5 56 4.9 0.4 5.7 5 1 0 5 5 5 0 Leucine Rich Repeat RNase_PH PF01138.21 KPI85596.1 - 1e-15 58.4 1.0 1.4e-15 58.0 1.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DAO PF01266.24 KPI85596.1 - 0.0087 15.7 1.2 0.01 15.5 1.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Vps8 PF12816.7 KPI85597.1 - 0.00044 19.8 0.4 0.089 12.3 0.0 3.5 3 0 0 3 3 3 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 KPI85597.1 - 0.0044 16.9 4.0 0.0059 16.5 0.0 3.1 3 0 0 3 3 3 1 Region in Clathrin and VPS TetR_C_36 PF18598.1 KPI85597.1 - 0.25 11.3 3.5 1.4 8.9 0.1 3.2 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain EutA PF06277.11 KPI85598.1 - 0.57 9.0 7.0 0.046 12.6 0.7 1.9 1 1 1 2 2 2 0 Ethanolamine utilisation protein EutA Acetate_kinase PF00871.17 KPI85598.1 - 1.4 7.5 4.9 1.4 7.5 3.7 1.7 1 1 0 1 1 1 0 Acetokinase family Ferrochelatase PF00762.19 KPI85599.1 - 1.3e-23 83.6 0.0 6.9e-14 51.6 0.0 3.1 1 1 2 3 3 3 3 Ferrochelatase CH PF00307.31 KPI85600.1 - 7.5e-11 42.2 0.0 1.6e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain IF-2B PF01008.17 KPI85601.1 - 3.8e-73 246.1 1.0 4.4e-73 245.9 1.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Got1 PF04178.12 KPI85602.1 - 3.8e-28 98.2 15.7 4.8e-28 97.9 15.7 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family PGG PF13962.6 KPI85602.1 - 0.00025 20.8 6.7 0.00042 20.1 6.4 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF3429 PF11911.8 KPI85602.1 - 0.034 14.4 3.0 0.034 14.4 3.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3429) Phage_holin_1 PF04531.13 KPI85602.1 - 1.4 9.5 6.0 3.3 8.3 1.8 2.5 1 1 1 2 2 2 0 Bacteriophage holin Gemini_mov PF01708.16 KPI85602.1 - 1.4 8.7 3.7 7 6.5 3.3 2.3 2 1 0 2 2 2 0 Geminivirus putative movement protein EMP70 PF02990.16 KPI85602.1 - 2 7.0 10.6 2.3 6.8 10.6 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 UPF0029 PF01205.19 KPI85603.1 - 9.8e-29 99.8 0.0 1.7e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 KPI85603.1 - 0.013 15.8 2.7 0.065 13.5 1.2 2.4 1 1 0 1 1 1 0 RWD domain 2OG-FeII_Oxy_2 PF13532.6 KPI85604.1 - 2.7e-08 34.2 0.0 1.6e-07 31.7 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LXG PF04740.12 KPI85604.1 - 0.03 14.0 0.2 0.05 13.3 0.2 1.4 1 0 0 1 1 1 0 LXG domain of WXG superfamily BCOR PF15808.5 KPI85604.1 - 0.062 13.5 0.2 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 BCL-6 co-repressor, non-ankyrin-repeat region Blt1 PF12754.7 KPI85604.1 - 0.073 13.4 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Blt1 N-terminal domain FlaC_arch PF05377.11 KPI85604.1 - 0.13 12.7 0.1 0.28 11.6 0.1 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DnaJ PF00226.31 KPI85607.1 - 8.9e-06 25.8 0.0 1.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain HTH_38 PF13936.6 KPI85607.1 - 0.0035 17.1 0.1 0.011 15.5 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain PSP1 PF04468.12 KPI85608.1 - 0.18 12.1 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Tubulin PF00091.25 KPI85609.1 - 1.2e-35 123.5 0.0 1.7e-33 116.5 0.0 3.5 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 KPI85609.1 - 0.00086 18.6 0.0 0.002 17.4 0.0 1.5 2 0 0 2 2 2 1 Tubulin like Desulfoferrod_N PF06397.12 KPI85610.1 - 0.44 10.2 2.6 0.77 9.4 2.6 1.4 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain PrmA PF06325.13 KPI85612.1 - 4.7e-09 36.1 0.0 7.1e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KPI85612.1 - 1.3e-06 29.0 0.0 5.8e-06 26.9 0.0 2.2 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_16 PF10294.9 KPI85612.1 - 1.4e-05 24.9 0.0 2.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 KPI85612.1 - 3.4e-05 23.7 0.0 6.5e-05 22.8 0.0 1.5 2 0 0 2 2 2 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 KPI85612.1 - 0.00021 21.0 0.0 0.00033 20.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PCMT PF01135.19 KPI85612.1 - 0.00022 21.1 0.0 0.00036 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 KPI85612.1 - 0.00028 20.5 0.0 0.00048 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 KPI85612.1 - 0.0029 18.2 0.0 0.0078 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 KPI85612.1 - 0.0036 16.4 0.0 0.0059 15.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 KPI85612.1 - 0.004 17.9 0.0 0.0083 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KPI85612.1 - 0.0049 16.2 0.0 0.0071 15.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 KPI85612.1 - 0.026 14.3 0.0 0.055 13.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 KPI85612.1 - 0.042 14.9 0.0 0.18 12.8 0.0 2.1 3 0 0 3 3 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 KPI85612.1 - 0.092 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 KPI85612.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 KPI85612.1 - 0.22 10.7 0.0 0.57 9.3 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase Thymidylat_synt PF00303.19 KPI85613.1 - 6.5e-110 366.5 0.0 8.5e-110 366.1 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 KPI85613.1 - 3.8e-19 68.9 0.0 3.2e-18 65.9 0.0 2.4 1 1 0 1 1 1 1 Dihydrofolate reductase EF-hand_7 PF13499.6 KPI85614.1 - 0.13 12.7 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair Glu-tRNAGln PF02686.15 KPI85615.1 - 0.17 12.2 0.7 17 5.8 0.0 2.4 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit LNS2 PF08235.13 KPI85616.1 - 2.1e-81 272.7 0.0 3.1e-81 272.1 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KPI85616.1 - 9e-19 67.3 0.0 1.8e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region HrpB7 PF09486.10 KPI85617.1 - 0.012 16.0 2.0 0.012 16.0 2.0 3.2 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) APG6_N PF17675.1 KPI85617.1 - 0.071 13.6 11.5 0.71 10.4 0.6 2.9 3 0 0 3 3 3 0 Apg6 coiled-coil region SlyX PF04102.12 KPI85617.1 - 1.6 9.4 7.8 6.3 7.5 0.5 3.3 4 0 0 4 4 4 0 SlyX Tropomyosin PF00261.20 KPI85617.1 - 2 7.7 13.0 0.72 9.2 0.6 2.6 3 0 0 3 3 3 0 Tropomyosin DUF2721 PF11026.8 KPI85617.1 - 2.9 7.8 10.6 0.053 13.4 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) ADIP PF11559.8 KPI85617.1 - 3.7 7.6 11.7 3.2 7.8 1.9 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 KPI85617.1 - 6.5 5.5 6.3 1.4 7.7 0.7 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Herpes_LMP1 PF05297.11 KPI85619.1 - 0.39 9.9 9.0 0.71 9.0 9.0 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF4131 PF13567.6 KPI85620.1 - 0.17 11.5 0.7 2.4 7.8 0.1 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) DUF4247 PF14042.6 KPI85620.1 - 0.23 12.1 4.0 0.81 10.4 0.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4247) LRR_6 PF13516.6 KPI85622.1 - 0.00032 20.5 0.0 12 6.3 0.0 4.2 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 KPI85622.1 - 0.054 13.9 0.1 7.8 7.1 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI85622.1 - 0.11 12.3 0.2 26 4.7 0.0 3.1 2 1 1 3 3 3 0 Leucine rich repeat Syntaxin-6_N PF09177.11 KPI85623.1 - 0.002 18.6 15.5 0.0088 16.6 0.0 4.3 3 1 0 4 4 4 1 Syntaxin 6, N-terminal Goodbye PF17109.5 KPI85623.1 - 0.025 15.0 1.0 0.58 10.6 0.3 2.9 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain Hrs_helical PF12210.8 KPI85623.1 - 0.06 13.9 4.8 2 9.0 1.1 3.5 2 1 1 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate HsbA PF12296.8 KPI85623.1 - 0.16 12.4 7.6 2.7 8.4 1.8 3.3 2 1 1 3 3 3 0 Hydrophobic surface binding protein A zf-C4H2 PF10146.9 KPI85623.1 - 4.9 7.4 12.8 7.1 6.9 11.9 1.8 1 1 0 1 1 1 0 Zinc finger-containing protein DUF1736 PF08409.11 KPI85624.1 - 5.7e-19 67.9 1.3 3.1e-17 62.3 0.8 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF1736) MORN PF02493.20 KPI85626.1 - 2.5e-10 39.6 15.9 8.4e-06 25.4 0.0 6.7 6 0 0 6 6 6 3 MORN repeat DUF3823 PF12866.7 KPI85626.1 - 0.44 10.9 2.4 4.5 7.6 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3823) N-terminal domain AAA_16 PF13191.6 KPI85627.1 - 3.5e-09 37.3 1.1 0.00012 22.5 0.0 3.3 2 1 1 3 3 3 2 AAA ATPase domain NB-ARC PF00931.22 KPI85627.1 - 2.4e-07 30.2 0.0 0.0013 18.0 0.0 2.4 1 1 1 2 2 2 2 NB-ARC domain NACHT PF05729.12 KPI85627.1 - 0.0013 18.7 0.1 0.44 10.5 0.0 2.6 1 1 1 2 2 2 2 NACHT domain AAA_25 PF13481.6 KPI85627.1 - 0.0052 16.4 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 KPI85627.1 - 0.018 15.5 0.0 0.049 14.0 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RINT1_TIP1 PF04437.13 KPI85627.1 - 0.02 13.8 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 RINT-1 / TIP-1 family ATPase_2 PF01637.18 KPI85627.1 - 0.18 11.7 0.0 1.2 9.0 0.0 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 KPI85627.1 - 0.23 11.0 0.0 0.44 10.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PGK PF00162.19 KPI85628.1 - 9.9e-136 452.6 0.0 2.1e-135 451.5 0.0 1.5 1 1 0 1 1 1 1 Phosphoglycerate kinase PGK PF00162.19 KPI85629.1 - 3.7e-157 523.1 0.0 4.4e-157 522.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF2477 PF10631.9 KPI85629.1 - 1.9 9.2 10.8 19 5.9 10.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) Ion_trans_2 PF07885.16 KPI85630.1 - 1.7e-12 47.1 6.1 1.7e-12 47.1 6.1 2.5 2 1 1 3 3 3 1 Ion channel BK_channel_a PF03493.18 KPI85630.1 - 3.2e-09 36.9 0.0 9.1e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit MRG PF05712.13 KPI85632.1 - 0.0032 16.8 0.0 0.0034 16.7 0.0 1.1 1 0 0 1 1 1 1 MRG BRCA-2_OB1 PF09103.10 KPI85633.1 - 8.8e-24 83.8 0.0 2.1e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA2 PF00634.18 KPI85633.1 - 1.7e-07 30.8 0.0 0.0011 18.6 0.0 2.5 2 0 0 2 2 2 2 BRCA2 repeat zf-RanBP PF00641.18 KPI85633.1 - 0.093 12.1 2.9 0.21 10.9 2.9 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others ASF1_hist_chap PF04729.13 KPI85634.1 - 1.1e-44 152.1 0.0 1.3e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone PHO4 PF01384.20 KPI85636.1 - 3.9e-109 364.8 20.5 4.7e-109 364.5 20.5 1.1 1 0 0 1 1 1 1 Phosphate transporter family HEV_ORF1 PF02444.16 KPI85636.1 - 5.8 7.5 8.6 53 4.4 0.1 3.6 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) DOT1 PF08123.13 KPI85637.1 - 2.7e-18 66.2 0.0 3.7e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 KPI85637.1 - 3.9e-05 24.3 0.0 6.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI85637.1 - 4.1e-05 23.4 0.0 5.8e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI85637.1 - 0.00023 21.8 0.0 0.00039 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI85637.1 - 0.017 14.9 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 KPI85637.1 - 0.019 14.3 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 KPI85637.1 - 0.058 14.1 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 KPI85637.1 - 0.094 13.1 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_4 PF02390.17 KPI85637.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase UPF0020 PF01170.18 KPI85637.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 WD40 PF00400.32 KPI85638.1 - 1.9e-17 63.3 9.3 3.4e-05 24.5 0.2 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85638.1 - 1.8e-06 28.2 0.1 0.039 14.2 0.0 4.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KPI85638.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Nucleoporin_N PF08801.11 KPI85638.1 - 0.11 11.2 0.0 1.1 7.9 0.1 2.1 2 0 0 2 2 2 0 Nup133 N terminal like RNA_pol_Rpb2_6 PF00562.28 KPI85639.1 - 6.5e-116 387.6 0.0 1.2e-115 386.7 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KPI85639.1 - 4.1e-45 153.8 1.1 5.9e-45 153.3 1.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 KPI85639.1 - 1.8e-31 108.3 0.4 5.4e-31 106.9 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 KPI85639.1 - 3.8e-20 72.3 0.2 8.3e-20 71.2 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 KPI85639.1 - 3.2e-19 69.0 1.7 3.2e-19 69.0 1.7 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KPI85639.1 - 4.8e-19 68.3 0.2 1.7e-18 66.6 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KPI85639.1 - 1.3e-06 28.8 1.0 5.2e-06 26.9 1.0 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Chlorophyllase PF07224.11 KPI85639.1 - 0.054 12.5 0.0 0.095 11.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Peptidase_M20 PF01546.28 KPI85640.1 - 3e-22 79.3 0.2 5.1e-22 78.6 0.1 1.5 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI85640.1 - 1.6e-10 40.9 0.1 2.8e-10 40.1 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KPI85640.1 - 0.0018 18.0 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 zf-C3HC4_2 PF13923.6 KPI85640.1 - 0.092 12.6 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Mog1 PF04603.12 KPI85641.1 - 5e-34 117.6 0.0 6.8e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein DUF2975 PF11188.8 KPI85642.1 - 1.5 8.7 10.5 7.6 6.4 10.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) MscS_TM PF12794.7 KPI85642.1 - 2.5 6.9 12.0 23 3.7 12.0 2.4 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Helicase_C PF00271.31 KPI85643.1 - 1.1e-10 41.9 0.0 9.7e-10 38.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI85643.1 - 7.3e-09 35.6 0.0 2.3e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase HHH_5 PF14520.6 KPI85643.1 - 0.00092 19.8 0.0 0.002 18.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain MAP65_ASE1 PF03999.12 KPI85643.1 - 7.5 5.1 8.6 13 4.4 8.6 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Baculo_LEF5_C PF11792.8 KPI85644.1 - 0.0092 15.6 1.4 0.021 14.5 1.4 1.6 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain Mito_carr PF00153.27 KPI85645.1 - 6.6e-33 112.5 2.6 1.3e-13 50.7 0.4 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Bro-N PF02498.17 KPI85646.1 - 0.057 14.1 0.2 0.13 13.0 0.2 1.6 1 0 0 1 1 1 0 BRO family, N-terminal domain DUF2207 PF09972.9 KPI85646.1 - 0.07 11.9 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Aa_trans PF01490.18 KPI85646.1 - 0.35 9.5 0.5 0.7 8.5 0.3 1.5 2 0 0 2 2 2 0 Transmembrane amino acid transporter protein Radical_SAM_C PF16199.5 KPI85647.1 - 9.8e-17 60.8 0.3 1.9e-16 59.8 0.3 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KPI85647.1 - 2e-15 57.6 0.0 1.7e-14 54.5 0.0 2.2 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KPI85647.1 - 3.5e-05 24.0 0.1 8.9e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KPI85647.1 - 0.00029 20.8 0.1 0.00062 19.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DNA_pol_B PF00136.21 KPI85649.1 - 4.9e-79 266.2 0.0 6.7e-79 265.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KPI85649.1 - 1e-07 31.4 0.0 0.007 15.5 0.0 2.6 3 0 0 3 3 3 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KPI85649.1 - 0.00077 19.9 0.7 0.0063 16.9 0.7 2.5 1 1 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DUF99 PF01949.16 KPI85649.1 - 0.068 12.6 0.0 0.38 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF99 YceI PF04264.13 KPI85650.1 - 3.2e-06 27.8 0.0 4e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 YceI-like domain AAA_6 PF12774.7 KPI85651.1 - 1.2e-147 491.2 0.0 8.2e-147 488.4 0.0 2.4 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 KPI85651.1 - 4.8e-146 487.7 0.0 4.8e-146 487.7 0.0 3.9 3 1 0 3 3 2 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 KPI85651.1 - 4.2e-110 368.6 7.8 4.2e-110 368.6 7.8 5.1 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI85651.1 - 2.7e-96 321.9 2.0 5e-96 321.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KPI85651.1 - 1.1e-83 281.0 0.3 4.8e-83 278.9 0.0 2.3 3 0 0 3 3 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KPI85651.1 - 1.3e-80 269.7 0.4 1.3e-80 269.7 0.4 3.3 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI85651.1 - 1.2e-64 217.2 1.3 1.6e-59 200.5 0.0 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI85651.1 - 7.1e-56 188.5 0.4 2e-55 187.1 0.4 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI85651.1 - 3.3e-43 146.6 0.0 2e-41 140.8 0.0 4.0 5 0 0 5 5 4 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI85651.1 - 5.1e-42 144.1 16.1 5.1e-42 144.1 16.1 2.0 3 0 0 3 3 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KPI85651.1 - 3.6e-24 85.3 0.2 1.1e-06 28.8 0.0 5.9 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KPI85651.1 - 7.5e-24 84.3 0.0 3.2e-23 82.2 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KPI85651.1 - 3.3e-18 65.7 0.0 1.6e-17 63.6 0.0 2.3 1 0 0 1 1 1 1 AAA+ lid domain T2SSE PF00437.20 KPI85651.1 - 1.5e-06 27.5 0.4 0.037 13.1 0.0 3.9 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA PF00004.29 KPI85651.1 - 7.3e-06 26.4 1.1 0.45 10.9 0.0 4.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI85651.1 - 8e-06 26.3 9.1 0.54 10.6 0.0 6.5 6 0 0 6 6 4 1 AAA ATPase domain AAA_22 PF13401.6 KPI85651.1 - 0.00015 22.0 9.1 0.12 12.6 0.0 6.4 6 0 0 6 6 6 1 AAA domain Sigma54_activat PF00158.26 KPI85651.1 - 0.014 15.1 0.1 0.13 12.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 KPI85651.1 - 0.026 15.1 3.0 3.6 8.1 0.0 5.2 6 0 0 6 6 4 0 AAA domain FtsK_SpoIIIE PF01580.18 KPI85651.1 - 0.045 13.1 1.7 2.6 7.3 0.0 3.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 KPI85651.1 - 0.057 13.8 0.0 25 5.3 0.0 3.5 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 KPI85651.1 - 0.088 13.0 0.9 20 5.3 0.0 4.1 3 0 0 3 3 3 0 AAA domain His_kinase PF06580.13 KPI85651.1 - 0.091 13.1 0.2 2.5 8.5 0.0 3.6 2 0 0 2 2 2 0 Histidine kinase AAA_lid_7 PF17867.1 KPI85651.1 - 0.093 12.9 1.7 0.68 10.2 0.0 3.7 4 0 0 4 4 2 0 Midasin AAA lid domain DUF3289 PF11692.8 KPI85651.1 - 3 7.4 6.6 0.61 9.6 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3289) Nucleo_P87 PF07267.11 KPI85653.1 - 0.11 11.3 0.2 0.2 10.5 0.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PBP1_TM PF14812.6 KPI85653.1 - 0.18 12.2 10.9 0.11 12.8 1.8 2.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ank_2 PF12796.7 KPI85654.1 - 3e-05 24.5 2.4 0.0035 17.9 0.0 4.4 5 0 0 5 5 5 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI85654.1 - 0.0021 18.6 1.3 0.013 16.0 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI85654.1 - 0.0022 18.3 0.8 0.028 14.8 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI85654.1 - 0.23 12.1 4.4 0.46 11.2 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.30 KPI85654.1 - 0.68 10.5 5.5 0.21 12.1 0.1 3.0 3 0 0 3 3 3 0 Ankyrin repeat zf-C3HC4_3 PF13920.6 KPI85655.1 - 5.3e-09 35.8 23.0 5.3e-09 35.8 23.0 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Phage_holin_2_3 PF16080.5 KPI85655.1 - 0.15 11.8 0.0 0.4 10.5 0.0 1.7 1 0 0 1 1 1 0 Bacteriophage holin family HP1 AAA PF00004.29 KPI85656.1 - 4.1e-33 114.6 0.0 2.5e-21 76.5 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI85656.1 - 3.4e-07 30.6 0.5 0.0016 18.7 0.0 3.4 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 KPI85656.1 - 7.9e-07 29.6 2.9 0.00032 21.1 0.2 4.3 3 2 0 4 4 3 1 AAA ATPase domain AAA_33 PF13671.6 KPI85656.1 - 8.5e-07 29.2 0.0 0.073 13.2 0.0 3.1 2 0 0 2 2 2 2 AAA domain Zot PF05707.12 KPI85656.1 - 2.1e-06 27.5 1.7 0.0096 15.6 0.1 3.8 2 2 2 4 4 4 2 Zonular occludens toxin (Zot) AAA_14 PF13173.6 KPI85656.1 - 8.1e-06 25.9 0.0 0.00049 20.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KPI85656.1 - 3e-05 23.8 0.0 0.0035 17.1 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 KPI85656.1 - 5e-05 22.9 0.3 0.00089 18.8 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 KPI85656.1 - 5.2e-05 23.3 0.0 0.0033 17.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KPI85656.1 - 0.00015 21.1 0.1 0.024 13.9 0.1 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 KPI85656.1 - 0.00026 21.4 0.0 0.04 14.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase ABC_tran PF00005.27 KPI85656.1 - 0.00031 21.3 0.5 0.0055 17.2 0.0 3.1 3 1 0 3 3 2 1 ABC transporter Bac_DnaA PF00308.18 KPI85656.1 - 0.0007 19.5 0.1 0.0018 18.2 0.1 1.6 1 0 0 1 1 1 1 Bacterial dnaA protein RuvB_N PF05496.12 KPI85656.1 - 0.0011 18.8 0.0 0.1 12.3 0.0 3.3 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain DUF2075 PF09848.9 KPI85656.1 - 0.0019 17.5 0.2 2.2 7.4 0.1 3.4 2 1 1 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.14 KPI85656.1 - 0.0034 17.5 0.0 0.012 15.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KPI85656.1 - 0.0045 16.4 0.1 0.034 13.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 KPI85656.1 - 0.0046 16.7 0.0 0.65 9.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KPI85656.1 - 0.0079 16.1 0.2 0.45 10.4 0.0 2.7 2 0 0 2 2 2 1 NACHT domain Sigma54_activat PF00158.26 KPI85656.1 - 0.0082 15.9 0.1 1.3 8.7 0.1 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF3135 PF11333.8 KPI85656.1 - 0.0095 16.2 0.1 0.029 14.6 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3135) AAA_18 PF13238.6 KPI85656.1 - 0.0098 16.4 0.0 0.23 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 KPI85656.1 - 0.013 14.9 2.2 0.046 13.2 0.1 2.7 2 2 1 3 3 3 0 PhoH-like protein SRP54 PF00448.22 KPI85656.1 - 0.018 14.7 0.3 0.094 12.3 0.0 2.3 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 KPI85656.1 - 0.028 14.3 0.2 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase E3_UFM1_ligase PF09743.9 KPI85656.1 - 0.036 13.7 0.0 0.086 12.4 0.0 1.6 1 0 0 1 1 1 0 E3 UFM1-protein ligase 1 ATPase_2 PF01637.18 KPI85656.1 - 0.048 13.6 0.0 1.3 8.9 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PEPCK_ATP PF01293.20 KPI85656.1 - 0.05 12.3 0.7 0.24 10.0 0.0 2.0 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase DUF815 PF05673.13 KPI85656.1 - 0.056 12.6 0.0 9 5.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF815) ATPase PF06745.13 KPI85656.1 - 0.057 12.8 0.3 2.3 7.5 0.0 2.4 2 0 0 2 2 2 0 KaiC Sigma54_activ_2 PF14532.6 KPI85656.1 - 0.058 13.5 0.1 0.25 11.4 0.0 2.1 2 0 0 2 2 1 0 Sigma-54 interaction domain Torsin PF06309.11 KPI85656.1 - 0.097 12.8 0.2 3.2 7.8 0.1 2.5 2 0 0 2 2 2 0 Torsin AAA_29 PF13555.6 KPI85656.1 - 0.1 12.3 1.7 3 7.6 0.3 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 KPI85656.1 - 0.14 12.1 0.4 0.97 9.4 0.1 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APS_kinase PF01583.20 KPI85656.1 - 0.15 11.9 0.2 0.82 9.5 0.1 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_10 PF12846.7 KPI85656.1 - 2.1 7.2 4.0 3.6 6.4 0.1 2.9 4 0 0 4 4 4 0 AAA-like domain zf-CCHC_4 PF14392.6 KPI85657.1 - 0.099 12.4 0.5 0.27 11.0 0.3 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 KPI85657.1 - 0.81 9.9 2.8 1.8 8.8 2.8 1.6 1 0 0 1 1 1 0 Zinc knuckle AAA_12 PF13087.6 KPI85658.1 - 2.6e-47 161.0 0.0 4.3e-47 160.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KPI85658.1 - 7.9e-37 127.4 6.7 1.9e-20 73.8 0.2 2.9 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 KPI85658.1 - 3e-09 36.9 0.0 0.0045 16.7 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KPI85658.1 - 3.2e-07 30.8 0.0 1.1e-06 29.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 KPI85658.1 - 6e-05 23.1 0.0 0.00016 21.7 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 KPI85658.1 - 0.00053 19.9 0.0 0.027 14.3 0.0 2.6 2 0 0 2 2 2 1 Helicase UvrD-helicase PF00580.21 KPI85658.1 - 0.0014 18.2 0.0 0.066 12.7 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 KPI85658.1 - 0.047 14.1 1.3 0.37 11.2 0.0 3.3 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 KPI85658.1 - 0.097 12.9 0.0 2.9 8.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain IBR PF01485.21 KPI85659.1 - 0.031 14.5 0.5 0.21 11.9 0.4 2.0 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Stomagen PF16851.5 KPI85659.1 - 0.035 14.1 0.2 0.035 14.1 0.2 1.7 2 0 0 2 2 2 0 Stomagen Bromodomain PF00439.25 KPI85660.1 - 2.4e-21 75.6 0.0 7.4e-11 42.0 0.0 2.4 2 0 0 2 2 2 2 Bromodomain MRG PF05712.13 KPI85660.1 - 0.00025 20.4 0.1 0.00056 19.3 0.1 1.5 1 0 0 1 1 1 1 MRG BSD PF03909.17 KPI85660.1 - 0.024 14.6 2.4 2.9 8.0 0.0 2.8 3 0 0 3 3 3 0 BSD domain MSA-2c PF12238.8 KPI85660.1 - 0.036 14.1 5.4 0.44 10.5 0.0 3.0 3 0 0 3 3 3 0 Merozoite surface antigen 2c Mito_carr PF00153.27 KPI85661.1 - 1.3e-46 156.4 6.6 4e-17 61.9 0.1 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein Rotamase_3 PF13616.6 KPI85661.1 - 0.0066 17.0 0.2 0.013 16.0 0.2 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain DUF883 PF05957.13 KPI85661.1 - 0.021 15.4 0.4 0.048 14.3 0.4 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DZR PF12773.7 KPI85662.1 - 0.00013 22.0 2.9 0.0099 15.9 0.5 2.5 2 0 0 2 2 2 2 Double zinc ribbon Mut7-C PF01927.16 KPI85662.1 - 0.063 13.4 0.3 0.18 11.9 0.1 1.8 2 0 0 2 2 2 0 Mut7-C RNAse domain Zn_Tnp_IS1595 PF12760.7 KPI85662.1 - 1.8 8.6 10.4 21 5.2 0.1 4.1 4 0 0 4 4 4 0 Transposase zinc-ribbon domain Mu-like_Com PF10122.9 KPI85662.1 - 2.3 7.7 9.3 76 2.9 7.3 3.4 2 1 0 2 2 2 0 Mu-like prophage protein Com MSP1a PF11670.8 KPI85662.1 - 2.5 7.3 8.2 0.086 12.1 1.6 1.8 2 1 0 2 2 2 0 Major surface protein 1a (MSP1a) Kelch_5 PF13854.6 KPI85663.1 - 8.3e-09 35.2 2.0 0.0031 17.4 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KPI85663.1 - 3.5e-07 30.1 4.3 0.053 13.5 0.0 5.5 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KPI85663.1 - 0.035 14.4 0.3 3.4 8.1 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 KPI85663.1 - 0.16 11.5 3.2 35 4.1 0.3 4.2 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 KPI85663.1 - 0.77 9.8 5.5 9.4 6.4 0.0 4.2 5 0 0 5 5 5 0 Kelch motif Peptidase_C97 PF05903.14 KPI85664.1 - 1.4e-22 80.2 0.1 1.8e-22 79.8 0.1 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF4796 PF16044.5 KPI85664.1 - 0.0017 18.0 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) Vault_3 PF17795.1 KPI85664.1 - 0.12 12.5 0.1 0.33 11.0 0.0 1.7 2 0 0 2 2 2 0 Major Vault Protein Repeat domain Peptidase_C97 PF05903.14 KPI85665.1 - 2.1e-22 79.6 0.1 3.2e-22 79.0 0.1 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF4796 PF16044.5 KPI85665.1 - 0.0082 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) DUF4690 PF15756.5 KPI85666.1 - 1.9 9.1 7.0 0.2 12.3 1.6 2.1 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Flagellar_rod PF05149.12 KPI85667.1 - 3.5e-91 305.6 16.0 3.5e-91 305.6 16.0 1.6 2 0 0 2 2 2 1 Paraflagellar rod protein UPF0242 PF06785.11 KPI85667.1 - 0.016 15.3 4.4 0.016 15.3 4.4 2.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Glutaredoxin2_C PF04399.13 KPI85667.1 - 0.089 12.6 2.6 0.35 10.7 0.7 2.7 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain DUF2570 PF10828.8 KPI85667.1 - 1.4 8.8 7.5 3 7.7 6.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) TF_AP-2 PF03299.14 KPI85667.1 - 1.5 8.7 8.3 0.33 10.9 0.2 3.1 1 1 3 4 4 4 0 Transcription factor AP-2 Agouti PF05039.12 KPI85667.1 - 2.8 8.7 9.0 6 7.7 1.4 3.5 2 1 1 3 3 3 0 Agouti protein tRNA_int_endo PF01974.17 KPI85669.1 - 2.7e-12 46.6 0.0 4.8e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Rota_NS53 PF00981.17 KPI85669.1 - 0.011 14.6 0.2 0.015 14.2 0.2 1.1 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) Pex2_Pex12 PF04757.14 KPI85669.1 - 0.032 13.8 0.0 3 7.4 0.0 2.1 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region DUF498 PF04430.14 KPI85670.1 - 2.3e-19 69.5 0.0 4.4e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) HA PF03457.14 KPI85670.1 - 0.0035 17.7 1.3 0.35 11.2 0.1 3.3 3 0 0 3 3 3 1 Helicase associated domain Ribosomal_L24e PF01246.20 KPI85670.1 - 0.95 9.7 3.0 3.1 8.1 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L24e CLP1_P PF16575.5 KPI85671.1 - 1.1e-08 35.2 0.0 3.2e-08 33.6 0.0 1.8 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 KPI85671.1 - 0.00017 21.9 0.0 0.00037 20.9 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA PF00004.29 KPI85671.1 - 0.045 14.2 0.0 0.16 12.4 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KPI85671.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase IL17 PF06083.11 KPI85672.1 - 0.091 13.2 0.3 0.27 11.7 0.0 1.8 2 0 0 2 2 2 0 Interleukin-17 Pkinase PF00069.25 KPI85674.1 - 5.5e-59 199.7 0.0 2.7e-58 197.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85674.1 - 1.2e-33 116.6 0.0 5.4e-33 114.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI85674.1 - 0.00023 20.1 0.0 0.00062 18.7 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KPI85674.1 - 0.00066 19.1 0.0 0.0045 16.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PAS PF00989.25 KPI85674.1 - 0.00078 19.4 0.0 0.0027 17.7 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 KPI85674.1 - 0.0023 18.2 0.0 0.0074 16.5 0.0 1.9 1 0 0 1 1 1 1 PAS domain APH PF01636.23 KPI85674.1 - 0.0028 17.6 0.0 0.0059 16.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI85674.1 - 0.02 14.3 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KPI85674.1 - 0.023 14.3 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 KPI85674.1 - 0.039 13.5 0.7 0.15 11.6 0.0 2.3 3 0 0 3 3 3 0 RIO1 family YrbL-PhoP_reg PF10707.9 KPI85674.1 - 0.1 12.1 0.0 0.72 9.3 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL TPPK_C PF12555.8 KPI85674.1 - 0.1 12.6 3.0 0.2 11.7 2.1 1.9 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal OKR_DC_1_N PF03709.15 KPI85674.1 - 0.14 12.4 0.1 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Myticin-prepro PF10690.9 KPI85674.1 - 0.17 12.2 2.7 0.43 10.9 2.7 1.7 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel EF-hand_7 PF13499.6 KPI85675.1 - 6.2e-30 103.5 0.7 2.4e-14 53.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI85675.1 - 2.4e-27 92.4 6.8 3.2e-07 29.4 1.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KPI85675.1 - 7.7e-22 75.3 5.2 1.9e-06 27.3 0.2 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KPI85675.1 - 1.6e-21 75.9 3.9 2.2e-10 40.2 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KPI85675.1 - 9.5e-13 47.0 8.8 0.00026 20.3 1.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KPI85675.1 - 1.2e-07 32.0 0.2 0.0021 18.4 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 KPI85675.1 - 0.00022 21.1 1.7 0.049 13.6 0.1 2.3 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KPI85675.1 - 0.022 14.7 0.1 0.097 12.6 0.0 2.1 2 1 0 2 2 2 0 Caleosin related protein IFR3_antag PF14754.6 KPI85675.1 - 0.089 12.0 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Papain-like auto-proteinase NUDIX PF00293.28 KPI85677.1 - 2.5e-12 46.9 0.0 4.8e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DUF1619 PF07773.11 KPI85678.1 - 3.6e-44 152.0 0.1 6.7e-42 144.5 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1619) WD40 PF00400.32 KPI85680.1 - 2e-13 50.6 9.8 0.0028 18.5 0.2 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Delta_lysin PF05372.11 KPI85680.1 - 0.06 12.6 0.6 2.2 7.6 0.1 2.5 2 0 0 2 2 2 0 Delta lysin family Lysis_col PF02402.16 KPI85680.1 - 0.063 13.0 0.3 0.21 11.3 0.3 2.0 1 0 0 1 1 1 0 Lysis protein Shisa PF13908.6 KPI85682.1 - 0.0022 18.3 0.3 0.004 17.4 0.3 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator RskA PF10099.9 KPI85682.1 - 0.02 15.2 0.1 0.031 14.6 0.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA EphA2_TM PF14575.6 KPI85682.1 - 0.047 14.6 0.1 0.085 13.7 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SCIMP PF15050.6 KPI85682.1 - 0.092 13.2 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 SCIMP protein Adeno_E3_CR2 PF02439.15 KPI85682.1 - 0.13 12.0 5.1 0.23 11.3 5.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 FAM163 PF15069.6 KPI85682.1 - 0.3 11.5 3.5 0.51 10.8 3.5 1.3 1 0 0 1 1 1 0 FAM163 family Prominin PF05478.11 KPI85682.1 - 1.5 6.7 5.6 2.1 6.2 5.6 1.0 1 0 0 1 1 1 0 Prominin EF-hand_7 PF13499.6 KPI85683.1 - 7.6e-09 35.9 1.9 9.2e-09 35.6 0.7 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KPI85683.1 - 1.3e-05 24.9 0.6 0.088 12.7 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI85683.1 - 0.0079 16.0 1.1 0.12 12.4 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KPI85683.1 - 0.1 12.2 0.6 2.4 7.9 0.0 2.9 3 1 0 3 3 3 0 EF hand UCH PF00443.29 KPI85685.1 - 0.2 11.1 0.0 0.24 10.9 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PALP PF00291.25 KPI85686.1 - 8.4e-59 199.4 0.7 9.5e-59 199.2 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 KPI85686.1 - 0.0071 16.3 0.4 0.97 9.4 0.1 2.9 2 1 0 2 2 2 2 Zinc-binding dehydrogenase DUF2009 PF09418.10 KPI85687.1 - 2.5e-157 524.6 0.0 3e-157 524.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) LOH1CR12 PF10158.9 KPI85687.1 - 0.029 14.4 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Tumour suppressor protein SRP54 PF00448.22 KPI85688.1 - 9.1e-53 178.8 0.1 2e-52 177.7 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 KPI85688.1 - 2.6e-18 67.0 0.0 4.5e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 KPI85688.1 - 1.2e-07 31.8 0.0 2.7e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_22 PF13401.6 KPI85688.1 - 4.9e-06 26.8 0.0 5.9e-05 23.4 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI85688.1 - 3.3e-05 23.7 0.4 7.7e-05 22.5 0.4 1.6 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 KPI85688.1 - 0.0013 17.8 0.0 0.0036 16.3 0.0 1.7 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 KPI85688.1 - 0.0014 19.0 0.0 0.0047 17.3 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 KPI85688.1 - 0.0045 16.3 0.0 0.014 14.7 0.0 1.8 1 1 0 1 1 1 1 Zeta toxin NTPase_1 PF03266.15 KPI85688.1 - 0.0079 16.1 0.1 1.8 8.4 0.1 2.3 2 0 0 2 2 2 1 NTPase CbiA PF01656.23 KPI85688.1 - 0.014 15.5 0.2 0.064 13.3 0.2 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 KPI85688.1 - 0.015 15.7 0.0 0.054 13.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KPI85688.1 - 0.021 14.5 0.0 0.11 12.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KPI85688.1 - 0.021 14.9 0.5 0.17 12.0 0.5 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 KPI85688.1 - 0.026 14.7 0.0 0.078 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 KPI85688.1 - 0.038 13.9 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase ArsA_ATPase PF02374.15 KPI85688.1 - 0.067 12.4 0.1 0.17 11.0 0.1 1.6 1 0 0 1 1 1 0 Anion-transporting ATPase SQS_PSY PF00494.19 KPI85690.1 - 2.4e-12 46.9 0.0 3.9e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase TPR_1 PF00515.28 KPI85692.1 - 1.9e-05 24.3 2.8 0.00069 19.3 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 KPI85692.1 - 0.0012 18.5 0.0 1.9 8.3 0.0 2.9 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 KPI85692.1 - 0.0042 17.1 5.3 0.024 14.7 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat PRP3 PF08572.10 KPI85692.1 - 0.086 12.6 0.9 0.14 11.8 0.9 1.5 1 1 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) TPR_14 PF13428.6 KPI85692.1 - 0.14 13.1 7.1 2 9.4 0.2 4.0 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF3846 PF12957.7 KPI85692.1 - 0.15 12.4 0.0 0.49 10.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3846) TPR_16 PF13432.6 KPI85692.1 - 0.97 10.1 9.9 0.89 10.3 2.1 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat NUDIX PF00293.28 KPI85693.1 - 1.8e-15 57.1 0.1 4.7e-15 55.8 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain zf-NADH-PPase PF09297.11 KPI85693.1 - 2.7e-07 30.1 7.0 4.3e-07 29.5 7.0 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain DZR PF12773.7 KPI85693.1 - 0.026 14.5 3.3 0.049 13.7 3.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon SQS_PSY PF00494.19 KPI85694.1 - 5.3e-40 137.6 0.1 9.1e-40 136.8 0.0 1.4 2 0 0 2 2 2 1 Squalene/phytoene synthase Inositol_P PF00459.25 KPI85696.1 - 6.1e-17 62.0 0.7 1e-09 38.3 0.3 2.9 2 1 0 2 2 2 2 Inositol monophosphatase family DUF4588 PF15251.6 KPI85698.1 - 0.0021 17.9 0.5 0.0021 17.9 0.5 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4588) Adeno_terminal PF02459.15 KPI85698.1 - 0.051 12.0 0.3 0.062 11.7 0.3 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein MHB PF16525.5 KPI85699.1 - 0.0062 16.8 0.0 0.0086 16.3 0.0 1.3 1 0 0 1 1 1 1 Haemophore, haem-binding Nup54 PF13874.6 KPI85700.1 - 1.5e-22 80.3 1.5 2.9e-22 79.3 1.5 1.5 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 KPI85700.1 - 0.0019 18.1 1.3 0.0055 16.6 0.3 2.3 2 0 0 2 2 2 1 Nup54 C-terminal interacting domain Spectrin PF00435.21 KPI85700.1 - 0.3 11.6 4.8 0.11 13.0 1.2 2.1 2 0 0 2 2 2 0 Spectrin repeat Clathrin PF00637.20 KPI85701.1 - 6.8e-08 32.5 0.4 6.8e-08 32.5 0.4 2.2 3 0 0 3 3 3 1 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 KPI85701.1 - 0.0094 16.0 12.9 0.02 14.9 12.9 1.6 1 0 0 1 1 1 1 Zinc-finger VPS11_C PF12451.8 KPI85701.1 - 0.013 15.7 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Vps39_2 PF10367.9 KPI85701.1 - 0.024 15.1 2.7 0.059 13.8 2.7 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-ANAPC11 PF12861.7 KPI85701.1 - 0.049 13.7 4.4 0.13 12.3 4.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KPI85701.1 - 0.2 12.0 8.0 0.56 10.5 8.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KPI85701.1 - 0.95 9.5 11.4 0.64 10.1 6.3 2.8 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 KPI85701.1 - 1.3 9.0 16.2 0.39 10.7 10.9 2.4 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 KPI85701.1 - 6.8 7.1 13.8 2.9 8.3 10.3 2.3 2 0 0 2 2 2 0 Ring finger domain Aldo_ket_red PF00248.21 KPI85702.1 - 7.8e-54 182.9 0.0 1.2e-52 178.9 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 KPI85704.1 - 4.1e-57 193.5 0.0 1e-56 192.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85704.1 - 2.4e-28 99.1 0.0 4.4e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KPI85704.1 - 0.022 14.3 0.9 0.083 12.5 0.2 2.3 2 1 0 2 2 2 0 RIO1 family L71 PF02448.15 KPI85704.1 - 0.11 12.9 0.2 0.33 11.4 0.2 1.8 1 0 0 1 1 1 0 L71 family Pox_ser-thr_kin PF05445.11 KPI85704.1 - 0.14 11.1 0.2 0.21 10.5 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FAM76 PF16046.5 KPI85704.1 - 0.57 9.5 6.9 0.35 10.2 0.0 2.2 2 0 0 2 2 2 0 FAM76 protein DUF5347 PF17282.2 KPI85704.1 - 0.97 9.8 3.9 11 6.4 0.2 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5347) Ribosomal_L12 PF00542.19 KPI85705.1 - 1.8e-18 66.7 2.0 1.8e-18 66.7 2.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain CSTF2_hinge PF14327.6 KPI85705.1 - 0.15 12.5 0.1 2.2 8.8 0.0 2.6 2 1 1 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 COX14 PF14880.6 KPI85706.1 - 5.1 7.0 6.5 0.32 10.9 0.2 2.2 3 0 0 3 3 3 0 Cytochrome oxidase c assembly Pox_RNA_Pol_19 PF05320.12 KPI85707.1 - 0.13 12.2 0.2 0.24 11.4 0.2 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Maf1 PF09174.10 KPI85708.1 - 1.5e-24 87.1 0.0 2.1e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator DUF1771 PF08590.10 KPI85709.1 - 2e-16 60.1 5.9 2e-16 60.1 5.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) KH_1 PF00013.29 KPI85709.1 - 1.2e-09 37.9 1.9 1.9e-09 37.2 0.9 1.9 2 0 0 2 2 2 1 KH domain Smr PF01713.21 KPI85709.1 - 2.1e-06 28.0 0.6 5.1e-06 26.7 0.0 2.0 2 1 1 3 3 3 1 Smr domain KH_2 PF07650.17 KPI85709.1 - 0.0015 18.3 0.2 0.0015 18.3 0.2 2.1 3 0 0 3 3 3 1 KH domain KH_4 PF13083.6 KPI85709.1 - 0.065 13.1 0.1 0.16 11.9 0.1 1.8 1 0 0 1 1 1 0 KH domain adh_short_C2 PF13561.6 KPI85712.1 - 3.4e-61 206.8 0.1 4.1e-61 206.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KPI85712.1 - 9.4e-60 201.4 0.3 1.1e-59 201.2 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KPI85712.1 - 6.6e-13 49.0 0.1 8.9e-13 48.5 0.1 1.1 1 0 0 1 1 1 1 KR domain Ribosomal_S11 PF00411.19 KPI85712.1 - 0.1 13.0 0.1 0.28 11.6 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein S11 Arf PF00025.21 KPI85714.1 - 2.5e-78 261.5 0.2 2.8e-78 261.4 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KPI85714.1 - 1.1e-14 54.2 0.0 1.4e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KPI85714.1 - 4.9e-14 52.6 0.1 6.9e-14 52.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KPI85714.1 - 8.2e-14 51.5 0.8 1.3e-09 37.7 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KPI85714.1 - 2.7e-13 49.8 0.0 2.9e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KPI85714.1 - 1.1e-09 38.0 0.0 1.4e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI85714.1 - 3.8e-05 23.7 0.1 5.9e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KPI85714.1 - 0.0084 15.4 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase RsgA_GTPase PF03193.16 KPI85714.1 - 0.027 14.4 0.2 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 KPI85714.1 - 0.064 12.8 0.2 0.49 10.0 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 KPI85714.1 - 0.078 13.1 0.1 0.13 12.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain Ephrin_rec_like PF07699.13 KPI85718.1 - 0.0096 15.7 7.0 0.0096 15.7 7.0 6.0 6 1 1 7 7 7 1 Putative ephrin-receptor like TNFR_c6 PF00020.18 KPI85718.1 - 0.4 11.1 0.1 0.4 11.1 0.1 6.4 6 1 2 8 8 8 0 TNFR/NGFR cysteine-rich region cNMP_binding PF00027.29 KPI85719.1 - 0.0036 17.3 0.0 3.6 7.7 0.0 3.3 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain DNA_primase_S PF01896.19 KPI85720.1 - 5.1e-42 143.9 0.1 1.1e-41 142.8 0.1 1.6 1 1 0 1 1 1 1 DNA primase small subunit DUF4368 PF14287.6 KPI85720.1 - 0.089 13.1 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) UreE_C PF05194.12 KPI85722.1 - 0.095 13.2 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain DUF641 PF04859.12 KPI85724.1 - 0.0064 16.8 5.7 0.39 11.0 0.0 2.3 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Rep_4 PF05797.11 KPI85724.1 - 0.16 11.1 2.4 0.2 10.7 2.4 1.2 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) THF_DHG_CYH_C PF02882.19 KPI85725.1 - 1.9e-32 111.8 1.1 2.5e-30 104.9 1.4 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KPI85725.1 - 1.8e-25 89.5 0.0 5.4e-25 87.9 0.0 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SEP PF08059.13 KPI85727.1 - 8.9e-16 58.2 0.0 2.3e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 KPI85727.1 - 0.013 15.3 0.2 0.085 12.7 0.0 2.4 3 0 0 3 3 3 0 UBA-like domain CUE PF02845.16 KPI85727.1 - 0.015 15.0 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 CUE domain NACHT_sigma PF17106.5 KPI85727.1 - 0.11 12.7 3.1 0.34 11.1 2.6 2.1 2 0 0 2 2 2 0 Sigma domain on NACHT-NTPases Carn_acyltransf PF00755.20 KPI85728.1 - 6.8e-96 322.2 0.0 8.3e-96 321.9 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase API5 PF05918.11 KPI85729.1 - 1.4e-08 34.1 3.4 0.0016 17.4 1.1 2.3 2 0 0 2 2 2 2 Apoptosis inhibitory protein 5 (API5) UPF0147 PF03685.13 KPI85729.1 - 0.12 12.5 1.0 16 5.6 0.0 2.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) HEAT_2 PF13646.6 KPI85729.1 - 0.81 10.1 6.6 0.48 10.8 0.3 3.6 2 2 3 5 5 5 0 HEAT repeats Mito_carr PF00153.27 KPI85730.1 - 1e-09 38.2 1.1 3.4e-08 33.3 0.2 3.0 3 0 0 3 3 3 1 Mitochondrial carrier protein zf-Tim10_DDP PF02953.15 KPI85733.1 - 1.7e-10 40.4 3.5 1.9e-10 40.2 3.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TRAP_alpha PF03896.16 KPI85734.1 - 3e-17 62.7 0.1 3.6e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Wzt_C PF14524.6 KPI85734.1 - 0.057 13.5 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Wzt C-terminal domain Y_phosphatase3 PF13350.6 KPI85736.1 - 8.4e-57 192.8 0.0 9.5e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 KPI85736.1 - 0.02 14.5 0.0 0.048 13.2 0.0 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family TGBp3 PF02495.17 KPI85736.1 - 0.064 12.9 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 Triple gene block 3 PTPlike_phytase PF14566.6 KPI85736.1 - 0.083 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 KPI85736.1 - 0.086 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase NAP PF00956.18 KPI85740.1 - 4.8e-76 255.5 1.4 4.8e-76 255.5 1.4 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Sigma70_ner PF04546.13 KPI85740.1 - 0.011 15.7 12.0 4 7.3 8.3 3.5 2 2 0 2 2 2 0 Sigma-70, non-essential region DUF4121 PF13497.6 KPI85740.1 - 0.043 13.0 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) FliT PF05400.13 KPI85740.1 - 0.053 14.3 0.9 0.16 12.8 0.9 1.8 1 0 0 1 1 1 0 Flagellar protein FliT CENP-B_dimeris PF09026.10 KPI85740.1 - 2.1 8.8 19.8 5.5 7.4 13.2 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-RING_11 PF17123.5 KPI85741.1 - 1.2 9.0 5.3 0.28 11.0 1.3 2.0 2 0 0 2 2 2 0 RING-like zinc finger FUSC_2 PF13515.6 KPI85743.1 - 0.0018 18.4 5.6 0.0018 18.4 5.6 2.5 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_1 PF06081.11 KPI85743.1 - 0.068 13.3 5.1 0.023 14.8 1.3 2.2 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 DUF5330 PF17264.2 KPI85744.1 - 0.13 12.3 0.8 0.34 10.9 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5330) Cullin_Nedd8 PF10557.9 KPI85746.1 - 5.1e-13 48.9 3.7 1.1e-12 47.7 3.7 1.6 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.22 KPI85746.1 - 0.024 13.3 0.0 0.057 12.0 0.0 1.5 1 1 0 1 1 1 0 Cullin family Importin_rep_3 PF18806.1 KPI85746.1 - 0.068 13.2 0.0 0.43 10.7 0.0 2.3 2 0 0 2 2 2 0 Importin 13 repeat DUF2087 PF09860.9 KPI85746.1 - 0.11 12.7 0.3 19 5.5 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) PPR_2 PF13041.6 KPI85748.1 - 0.00014 22.0 0.1 0.13 12.5 0.0 3.9 3 1 1 4 4 4 1 PPR repeat family PPR_3 PF13812.6 KPI85748.1 - 0.012 15.7 0.4 1.2 9.3 0.0 3.4 3 1 0 4 4 4 0 Pentatricopeptide repeat domain ELYS PF13934.6 KPI85748.1 - 0.029 14.3 0.2 0.077 13.0 0.2 1.7 1 0 0 1 1 1 0 Nuclear pore complex assembly PPR_1 PF12854.7 KPI85748.1 - 0.041 13.6 0.0 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 PPR repeat PPR PF01535.20 KPI85748.1 - 0.16 12.2 0.0 0.64 10.4 0.0 2.0 2 0 0 2 2 2 0 PPR repeat BON PF04972.17 KPI85749.1 - 0.12 12.7 0.2 0.38 11.1 0.2 1.8 1 0 0 1 1 1 0 BON domain GlgS PF08971.11 KPI85750.1 - 0.016 15.2 0.1 0.034 14.2 0.1 1.5 1 0 0 1 1 1 0 Glycogen synthesis protein Med3 PF11593.8 KPI85750.1 - 0.3 10.2 6.6 0.36 10.0 6.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PspA_IM30 PF04012.12 KPI85751.1 - 0.041 13.4 5.2 0.054 13.1 5.2 1.1 1 0 0 1 1 1 0 PspA/IM30 family Sld5 PF05916.11 KPI85752.1 - 3.4e-07 30.7 0.0 4.5e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein zf-MYND PF01753.18 KPI85753.1 - 1.6e-07 31.3 6.2 1.6e-07 31.3 6.2 2.0 2 0 0 2 2 2 1 MYND finger zf-C6H2 PF15801.5 KPI85753.1 - 0.1 12.9 7.7 0.25 11.7 7.7 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Syntaxin-6_N PF09177.11 KPI85754.1 - 0.057 14.0 0.3 0.057 14.0 0.3 4.4 4 1 1 5 5 5 0 Syntaxin 6, N-terminal Gly_acyl_tr_N PF06021.11 KPI85754.1 - 0.07 13.2 2.3 0.17 12.0 2.3 1.6 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF4140 PF13600.6 KPI85754.1 - 0.075 13.5 28.9 0.17 12.4 0.1 5.6 4 1 1 5 5 5 0 N-terminal domain of unknown function (DUF4140) Baculo_PEP_C PF04513.12 KPI85754.1 - 0.15 12.1 2.4 9.2 6.3 1.1 2.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ComA PF02679.15 KPI85754.1 - 0.52 9.7 5.5 0.073 12.5 0.5 1.9 2 0 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) DUF501 PF04417.12 KPI85754.1 - 2.5 7.9 0.0 2.5 7.9 0.0 3.7 4 1 0 4 4 4 0 Protein of unknown function (DUF501) APG6_N PF17675.1 KPI85754.1 - 6.2 7.4 34.4 0.48 11.0 1.2 4.3 4 0 0 4 4 4 0 Apg6 coiled-coil region AAA_23 PF13476.6 KPI85754.1 - 8.1 6.9 14.3 1.3e+02 2.9 10.1 3.6 2 1 0 2 2 2 0 AAA domain YfkD PF14167.6 KPI85755.1 - 0.072 12.3 0.1 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 YfkD-like protein Macoilin PF09726.9 KPI85755.1 - 2.9 6.3 26.1 0.054 12.1 12.7 3.2 3 0 0 3 3 3 0 Macoilin family ShK PF01549.24 KPI85757.1 - 0.088 13.4 0.4 0.49 11.0 0.1 2.4 2 0 0 2 2 2 0 ShK domain-like H_PPase PF03030.16 KPI85758.1 - 5.1e-235 782.0 36.4 6.8e-235 781.6 36.4 1.2 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase DUF3638 PF12340.8 KPI85759.1 - 1.8e-30 106.0 0.2 6.2e-29 100.9 0.1 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 KPI85759.1 - 1.1e-15 56.7 0.2 3.2e-15 55.2 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) zf-RanBP PF00641.18 KPI85759.1 - 1e-06 27.9 22.7 9.4e-05 21.6 5.3 3.5 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 KPI85759.1 - 0.0011 18.3 2.0 0.0011 18.3 2.0 3.1 2 1 1 3 3 3 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Thioredoxin_8 PF13905.6 KPI85759.1 - 0.0034 17.7 0.0 0.0077 16.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Cyt-b5 PF00173.28 KPI85760.1 - 1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cyt-b5 PF00173.28 KPI85761.1 - 6.2e-07 29.5 0.0 8.1e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cyt-b5 PF00173.28 KPI85764.1 - 4e-05 23.7 0.1 6.5e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Dpy-30 PF05186.13 KPI85765.1 - 0.22 11.2 0.9 62 3.4 0.0 3.7 4 0 0 4 4 4 0 Dpy-30 motif Pkinase PF00069.25 KPI85767.1 - 1.3e-07 31.3 0.0 3e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain PH PF00169.29 KPI85767.1 - 1.6e-05 25.3 0.4 6e-05 23.5 0.4 1.8 1 1 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 KPI85767.1 - 4.1e-05 23.0 0.0 9.8e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PH_11 PF15413.6 KPI85767.1 - 0.00012 22.5 0.2 0.00024 21.5 0.0 1.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_4 PF15404.6 KPI85767.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 KPI85767.1 - 0.037 14.4 0.3 0.11 12.9 0.3 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain DnaB_bind PF10410.9 KPI85767.1 - 0.056 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase PH_6 PF15406.6 KPI85767.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 KPI85767.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PTS_EIIC_2 PF13303.6 KPI85768.1 - 0.036 13.1 0.0 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC AF0941-like PF14591.6 KPI85768.1 - 0.064 13.8 0.8 0.13 12.9 0.8 1.5 1 1 0 1 1 1 0 AF0941-like DUF4090 PF13319.6 KPI85769.1 - 0.0084 16.3 0.0 0.043 14.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4090) PMEI PF04043.15 KPI85770.1 - 3.7 7.9 7.8 0.34 11.3 2.1 2.1 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Kelch_6 PF13964.6 KPI85772.1 - 1.3e-18 66.5 0.6 2.9e-06 27.4 0.0 5.1 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KPI85772.1 - 3.6e-17 61.7 1.4 2.1e-10 40.0 0.0 4.0 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KPI85772.1 - 1.2e-15 57.2 4.4 3.1e-08 33.5 0.0 5.5 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KPI85772.1 - 2.2e-12 46.4 6.1 9.4e-07 28.6 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KPI85772.1 - 3.2e-11 42.9 11.9 3.7e-06 26.8 0.1 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 KPI85772.1 - 7.7e-05 22.9 0.5 0.12 12.7 0.0 4.2 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF5582 PF17819.1 KPI85774.1 - 0.015 15.7 0.3 0.015 15.7 0.3 1.7 2 1 0 2 2 2 0 Family of unknown function (DUF5582) Peptidase_M3_N PF08439.10 KPI85774.1 - 0.024 14.9 1.5 0.31 11.3 0.1 2.6 2 0 0 2 2 2 0 Oligopeptidase F EF-hand_7 PF13499.6 KPI85774.1 - 0.033 14.6 0.0 0.086 13.3 0.0 1.7 1 1 0 1 1 1 0 EF-hand domain pair DUF4400 PF14348.6 KPI85774.1 - 0.034 13.7 0.1 0.044 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) Chorein_N PF12624.7 KPI85775.1 - 1.2e-24 86.7 0.4 3.5e-11 43.2 0.0 2.6 2 0 0 2 2 2 2 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 KPI85775.1 - 1.3e-18 67.4 1.0 1.5e-11 44.4 0.0 2.4 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 KPI85775.1 - 6.4e-07 29.4 0.1 0.056 13.2 0.0 2.5 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal EF1_GNE PF00736.19 KPI85776.1 - 9.3e-27 93.0 1.0 1.5e-26 92.4 1.0 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain UBA2_C PF16195.5 KPI85776.1 - 0.047 14.4 4.4 0.089 13.5 4.4 1.4 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus PfkB PF00294.24 KPI85777.1 - 1.7e-45 155.6 0.2 1.3e-44 152.7 0.2 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase PI3_PI4_kinase PF00454.27 KPI85778.1 - 3.2e-33 115.6 0.0 4.1e-23 82.5 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 KPI85778.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) UK PF02512.14 KPI85779.1 - 0.01 16.3 0.0 0.028 15.0 0.0 1.6 1 0 0 1 1 1 0 Virulence determinant DUF4407 PF14362.6 KPI85780.1 - 2.9 7.2 8.0 5.2 6.3 8.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PDZ_assoc PF10600.9 KPI85780.1 - 6 7.8 8.8 0.45 11.4 1.6 2.7 2 0 0 2 2 2 0 PDZ-associated domain of NMDA receptors VMA21 PF09446.10 KPI85781.1 - 1.2e-05 25.3 7.5 1.8e-05 24.7 7.5 1.3 1 0 0 1 1 1 1 VMA21-like domain DUF2207 PF09972.9 KPI85781.1 - 0.00026 19.9 0.0 0.00031 19.7 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) BssC_TutF PF08201.11 KPI85781.1 - 0.2 11.7 0.0 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 BssC/TutF protein RseC_MucC PF04246.12 KPI85781.1 - 0.35 10.8 2.7 0.35 10.8 1.6 1.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC BBS1 PF14779.6 KPI85782.1 - 3.2e-83 279.1 0.0 6.9e-82 274.7 0.0 2.4 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 1 PHTB1_N PF14727.6 KPI85782.1 - 0.0031 16.9 0.1 0.057 12.8 0.1 2.6 2 1 0 3 3 3 1 PTHB1 N-terminus RAB3GAP2_N PF14655.6 KPI85782.1 - 0.0068 15.7 0.1 0.091 12.0 0.0 2.1 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Mcl1_mid PF12341.8 KPI85782.1 - 0.0095 15.3 1.0 0.18 11.2 0.2 2.8 2 2 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region BBS2_Mid PF14783.6 KPI85782.1 - 0.044 13.8 0.0 6.7 6.8 0.0 2.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region RNA_pol_Rpc4 PF05132.14 KPI85783.1 - 3.4e-09 37.3 0.1 3.6e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase III RPC4 DUF2009 PF09418.10 KPI85784.1 - 1.4e-171 571.6 0.0 1.6e-171 571.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) GTP_EFTU PF00009.27 KPI85785.1 - 9.8e-43 146.0 0.0 4.8e-40 137.2 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KPI85785.1 - 1.1e-13 51.4 0.0 2.8e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 KPI85785.1 - 0.00017 21.7 0.1 0.002 18.2 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 KPI85785.1 - 0.037 13.6 0.1 0.87 9.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 KPI85785.1 - 0.087 12.3 0.3 0.5 9.9 0.0 2.4 3 1 0 3 3 3 0 Ferrous iron transport protein B RRM_1 PF00076.22 KPI85787.1 - 1.1e-69 230.2 0.1 4.9e-17 61.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KPI85787.1 - 2.9e-24 85.0 0.1 5.4e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 KPI85787.1 - 1.5e-06 27.9 0.0 0.34 10.8 0.0 3.9 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM_3 PF08777.11 KPI85787.1 - 7.8e-06 25.9 1.0 6.4 6.9 0.0 4.3 3 1 1 4 4 4 2 RNA binding motif RRM_5 PF13893.6 KPI85787.1 - 4.7e-05 23.0 0.0 0.044 13.4 0.0 3.3 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI85787.1 - 4.8e-05 23.4 0.2 0.43 10.7 0.0 5.0 4 3 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KPI85787.1 - 0.0001 22.2 0.0 0.13 12.2 0.0 4.0 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Glycos_transf_4 PF00953.21 KPI85787.1 - 0.08 12.9 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 4 Forkhead_N PF08430.12 KPI85787.1 - 0.097 13.3 33.3 0.26 11.9 33.3 1.8 1 0 0 1 1 1 0 Forkhead N-terminal region HD_3 PF13023.6 KPI85790.1 - 2.2e-37 128.6 0.0 2.6e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 KPI85790.1 - 1.1e-10 41.5 0.0 1.7e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 KPI85790.1 - 1.2e-05 25.5 0.0 2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 HD domain SF3b10 PF07189.11 KPI85792.1 - 5.9e-15 55.1 0.0 6.6e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) RecC_C PF17946.1 KPI85792.1 - 0.063 13.1 0.0 0.063 13.1 0.0 1.1 1 0 0 1 1 1 0 RecC C-terminal domain TPR_2 PF07719.17 KPI85794.1 - 1.1e-13 50.1 10.1 0.027 14.6 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85794.1 - 1.5e-12 47.6 12.5 0.0007 19.8 0.2 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85794.1 - 7.9e-10 39.1 15.3 0.0003 21.3 1.2 5.0 4 2 1 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 KPI85794.1 - 3.6e-07 30.1 4.0 0.11 13.0 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI85794.1 - 4.3e-07 30.2 21.6 0.0047 17.6 0.1 6.8 4 3 4 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI85794.1 - 3.3e-06 26.7 11.4 1.7 8.6 0.0 6.1 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 KPI85794.1 - 6.6e-06 25.5 3.3 0.021 14.0 0.4 3.6 1 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85794.1 - 0.00029 20.8 7.9 8.3 6.9 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI85794.1 - 0.00055 19.8 13.3 0.022 14.8 0.0 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KPI85794.1 - 0.00071 20.1 8.4 7.6 7.4 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KPI85794.1 - 0.0017 18.0 2.9 15 5.3 0.0 5.3 5 0 0 5 5 5 0 TPR repeat TPR_MalT PF17874.1 KPI85794.1 - 0.0027 17.1 10.4 0.018 14.4 8.7 2.3 1 1 1 2 2 2 2 MalT-like TPR region ANAPC3 PF12895.7 KPI85794.1 - 0.003 17.8 7.1 1.2 9.4 0.0 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 KPI85794.1 - 0.022 15.4 21.5 0.16 12.7 0.2 4.8 5 2 1 6 6 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KPI85794.1 - 0.51 11.1 17.3 0.64 10.8 0.1 5.5 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI85794.1 - 0.56 10.2 18.3 12 5.9 0.3 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI85794.1 - 1.7 8.8 8.3 1 9.6 0.8 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat RIIa PF02197.17 KPI85795.1 - 5.1e-08 32.5 0.0 1.8e-07 30.7 0.0 2.0 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_7 PF13499.6 KPI85795.1 - 0.0069 16.8 0.0 0.95 10.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI85795.1 - 0.03 14.3 0.0 6.3 7.0 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain Pkinase PF00069.25 KPI85796.1 - 4.2e-41 141.1 0.0 7.2e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85796.1 - 6.2e-23 81.4 0.0 4.4e-22 78.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI85796.1 - 2.7e-09 36.8 0.0 5.9e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI85796.1 - 0.0035 17.3 0.0 0.01 15.8 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family DnaJ PF00226.31 KPI85798.1 - 1.5e-16 60.2 0.0 4e-10 39.7 0.0 2.4 2 0 0 2 2 2 2 DnaJ domain Fibin PF15819.5 KPI85798.1 - 0.031 14.0 1.9 0.052 13.3 1.9 1.3 1 0 0 1 1 1 0 Fin bud initiation factor homologue OmpH PF03938.14 KPI85798.1 - 1.6 9.0 8.2 2.7 8.3 8.2 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DEAD PF00270.29 KPI85799.1 - 1.1e-37 129.5 0.0 2.7e-37 128.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI85799.1 - 3.4e-24 85.3 0.1 2e-23 82.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KPI85799.1 - 5.5e-14 52.1 0.1 2.3e-13 50.2 0.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KPI85799.1 - 2.8e-05 24.2 0.0 7.3e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UPF0242 PF06785.11 KPI85799.1 - 1.2 9.2 11.8 0.28 11.3 4.5 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Hydrolase_4 PF12146.8 KPI85800.1 - 9.6e-14 51.2 0.0 1.1e-08 34.6 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI85800.1 - 3.5e-11 43.3 0.1 6.9e-08 32.4 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KPI85800.1 - 1.3e-07 32.5 1.1 6.8e-07 30.1 0.3 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KPI85800.1 - 0.00052 19.9 0.6 0.0017 18.2 0.6 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 KPI85800.1 - 0.0027 17.3 0.0 2.2 7.8 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 KPI85800.1 - 0.0032 17.3 0.0 0.17 11.6 0.0 2.4 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 KPI85800.1 - 0.005 15.6 0.0 0.0081 14.9 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 KPI85800.1 - 0.0052 16.3 1.2 0.55 9.7 0.0 2.9 3 0 0 3 3 3 1 Prolyl oligopeptidase family BAAT_C PF08840.11 KPI85800.1 - 0.018 14.9 0.0 0.072 13.0 0.0 1.8 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal UPF0227 PF05728.12 KPI85800.1 - 0.027 14.4 0.0 0.085 12.8 0.0 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 KPI85800.1 - 0.047 13.4 0.1 0.3 10.8 0.1 2.0 1 1 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 KPI85800.1 - 0.049 13.7 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Ank_2 PF12796.7 KPI85801.1 - 5e-12 46.2 0.0 1.1e-08 35.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI85801.1 - 3.3e-10 40.3 0.2 0.00087 19.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) C2 PF00168.30 KPI85801.1 - 5.5e-10 39.5 0.0 9.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain Ank_5 PF13857.6 KPI85801.1 - 7e-07 29.4 0.2 0.0016 18.7 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI85801.1 - 1.9e-05 24.9 0.1 0.46 11.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KPI85801.1 - 0.00061 20.0 0.1 2.9 8.8 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat YEATS PF03366.16 KPI85803.1 - 4.2e-16 58.7 0.0 7.7e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 YEATS family SDA1 PF05285.12 KPI85803.1 - 0.73 9.2 16.9 0.67 9.3 11.2 2.2 2 0 0 2 2 2 0 SDA1 PALP PF00291.25 KPI85804.1 - 2.3e-53 181.5 0.3 2.6e-53 181.4 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HlyIII PF03006.20 KPI85806.1 - 3.6e-13 49.8 14.1 9.9e-06 25.4 0.4 3.1 3 0 0 3 3 3 3 Haemolysin-III related Prefoldin PF02996.17 KPI85811.1 - 2.2e-21 76.0 1.7 2.2e-21 76.0 1.7 1.8 1 1 1 2 2 2 1 Prefoldin subunit Prefoldin_2 PF01920.20 KPI85811.1 - 0.012 15.6 4.8 0.051 13.5 0.4 2.5 2 1 1 3 3 3 0 Prefoldin subunit DUF4854 PF16146.5 KPI85811.1 - 0.043 14.1 2.7 2 8.8 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4854) Sec20 PF03908.13 KPI85811.1 - 0.13 12.2 4.5 2.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Sec20 Torus PF16131.5 KPI85812.1 - 0.073 13.8 2.4 0.22 12.3 2.0 2.0 1 1 0 1 1 1 0 Torus domain Dicty_REP PF05086.12 KPI85812.1 - 0.52 8.2 5.2 1.1 7.2 5.2 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein HeH PF12949.7 KPI85813.1 - 0.014 15.1 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 HeH/LEM domain AAA PF00004.29 KPI85817.1 - 1.3e-38 132.5 0.7 3.5e-38 131.0 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KPI85817.1 - 1.7e-16 59.9 0.9 4.6e-16 58.5 0.9 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 KPI85817.1 - 2.7e-12 46.3 0.2 7e-12 45.0 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KPI85817.1 - 5.5e-06 26.4 0.0 4.9e-05 23.3 0.0 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI85817.1 - 2.2e-05 24.9 1.1 0.0023 18.3 0.0 2.7 2 2 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 KPI85817.1 - 0.00031 20.9 0.0 0.0022 18.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KPI85817.1 - 0.00062 20.1 2.2 0.22 11.8 0.1 3.1 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 KPI85817.1 - 0.0011 18.8 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KPI85817.1 - 0.0011 18.2 0.4 0.0056 15.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 KPI85817.1 - 0.0018 18.4 0.4 0.028 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KPI85817.1 - 0.0081 15.6 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KPI85817.1 - 0.013 15.2 0.0 0.051 13.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 KPI85817.1 - 0.014 15.3 0.0 0.035 14.0 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_3 PF07726.11 KPI85817.1 - 0.051 13.4 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KPI85817.1 - 0.062 12.7 0.1 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein Sigma54_activat PF00158.26 KPI85817.1 - 0.066 12.9 0.0 0.37 10.5 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 KPI85817.1 - 0.072 12.4 0.9 0.14 11.4 0.0 1.9 3 0 0 3 3 3 0 KaiC AAA_18 PF13238.6 KPI85817.1 - 0.088 13.4 0.4 0.4 11.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KPI85817.1 - 0.11 12.2 1.0 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 KPI85817.1 - 0.27 11.5 2.2 1.2 9.4 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KPI85817.1 - 0.29 10.7 2.9 0.25 10.9 0.3 2.2 2 1 0 2 2 2 0 AAA domain V_ATPase_I PF01496.19 KPI85817.1 - 5.2 4.9 6.8 7.5 4.3 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UQ_con PF00179.26 KPI85818.1 - 1.3e-42 144.8 0.0 1.7e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KPI85818.1 - 0.0011 18.7 0.0 0.0018 18.0 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B DUF2397 PF09660.10 KPI85818.1 - 0.12 11.3 2.8 0.18 10.7 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) Acetyltransf_3 PF13302.7 KPI85819.1 - 3.6e-09 37.4 0.1 3.2e-08 34.3 0.0 2.4 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI85819.1 - 1.6e-06 28.4 0.0 2.5e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 KPI85819.1 - 0.0023 17.6 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RNA_pol PF00940.19 KPI85819.1 - 0.024 13.5 0.1 0.035 13.0 0.1 1.1 1 0 0 1 1 1 0 DNA-dependent RNA polymerase FR47 PF08445.10 KPI85819.1 - 0.028 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein NUFIP1 PF10453.9 KPI85819.1 - 0.066 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Acetyltransf_4 PF13420.7 KPI85819.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TrmO PF01980.16 KPI85820.1 - 8.8e-30 103.4 0.0 8.3e-24 84.1 0.0 2.4 2 0 0 2 2 2 2 tRNA-methyltransferase O PWWP PF00855.17 KPI85820.1 - 0.00015 22.1 2.0 0.00089 19.6 2.0 2.4 1 1 0 1 1 1 1 PWWP domain Cadherin_tail PF15974.5 KPI85820.1 - 0.015 15.6 0.9 0.24 11.7 0.1 2.3 2 0 0 2 2 2 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region DUF3597 PF12200.8 KPI85820.1 - 0.37 11.3 2.6 2.2 8.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Rer1 PF03248.13 KPI85821.1 - 1.9e-52 177.5 9.5 2.2e-52 177.3 9.5 1.0 1 0 0 1 1 1 1 Rer1 family DUF2244 PF10003.9 KPI85821.1 - 0.82 9.3 9.4 2.4 7.8 4.8 2.1 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) AAA PF00004.29 KPI85822.1 - 8.6e-44 149.2 0.0 1.8e-43 148.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI85822.1 - 2.4e-10 40.0 0.0 4.9e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KPI85822.1 - 3e-06 27.3 0.1 4.3e-05 23.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KPI85822.1 - 1.2e-05 25.6 0.1 0.0056 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 KPI85822.1 - 2.2e-05 24.9 0.2 0.00089 19.7 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KPI85822.1 - 2.6e-05 24.4 0.0 6.7e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KPI85822.1 - 0.00019 20.7 0.0 0.00035 19.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KPI85822.1 - 0.00025 20.8 0.0 0.00065 19.5 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KPI85822.1 - 0.0022 18.3 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 KPI85822.1 - 0.0051 16.7 0.0 0.33 10.8 0.0 2.5 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 KPI85822.1 - 0.0052 16.3 0.0 0.013 15.0 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 KPI85822.1 - 0.0064 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KPI85822.1 - 0.0079 16.2 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KPI85822.1 - 0.0081 16.5 0.0 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 KPI85822.1 - 0.0089 15.4 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KPI85822.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 KPI85822.1 - 0.011 15.0 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 KPI85822.1 - 0.011 16.2 0.0 0.035 14.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_3 PF07726.11 KPI85822.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KPI85822.1 - 0.013 15.2 0.0 0.057 13.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 KPI85822.1 - 0.047 13.4 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 KPI85822.1 - 0.051 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 NTPase Parvo_NS1 PF01057.17 KPI85822.1 - 0.08 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 KPI85822.1 - 0.094 12.0 0.0 0.25 10.6 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 KPI85822.1 - 0.12 11.8 0.2 0.29 10.6 0.1 1.6 1 1 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 KPI85822.1 - 0.13 11.8 0.0 0.42 10.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KPI85822.1 - 0.14 12.5 0.1 0.47 10.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KPI85822.1 - 0.15 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KPI85822.1 - 0.15 12.0 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Kinesin PF00225.23 KPI85823.1 - 2.4e-84 283.1 0.0 4.4e-47 160.6 0.0 2.6 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI85823.1 - 6.5e-22 78.1 0.0 1.8e-21 76.6 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding bZIP_1 PF00170.21 KPI85823.1 - 0.17 12.0 23.0 1.7 8.8 1.0 5.2 3 1 1 4 4 4 0 bZIP transcription factor Rab_bind PF16704.5 KPI85823.1 - 0.32 11.1 8.7 0.36 10.9 0.6 3.2 3 1 0 3 3 3 0 Rab binding domain YlqD PF11068.8 KPI85823.1 - 6.1 7.2 32.6 0.37 11.2 1.2 4.2 2 1 2 4 4 4 0 YlqD protein PPR PF01535.20 KPI85824.1 - 0.0002 21.4 0.0 0.51 10.7 0.0 3.1 3 0 0 3 3 3 2 PPR repeat TPR_16 PF13432.6 KPI85824.1 - 0.00024 21.7 7.6 0.51 11.0 0.2 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI85824.1 - 0.004 17.2 2.3 2.1 8.7 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat PPR_2 PF13041.6 KPI85824.1 - 0.044 14.0 0.0 7.9 6.8 0.0 2.8 2 0 0 2 2 2 0 PPR repeat family PPR_1 PF12854.7 KPI85824.1 - 0.06 13.1 0.0 0.63 9.8 0.0 2.6 2 0 0 2 2 2 0 PPR repeat TPR_4 PF07721.14 KPI85824.1 - 0.46 11.3 12.0 1.1 10.1 1.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85824.1 - 0.49 10.9 3.3 26 5.4 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85824.1 - 1.4 9.3 5.1 3 8.2 1.6 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat Abhydrolase_1 PF00561.20 KPI85825.1 - 4.8e-24 85.4 0.0 1.3e-18 67.6 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI85825.1 - 4.8e-10 39.1 0.5 1.1e-08 34.6 0.5 2.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI85825.1 - 8.5e-09 36.3 0.1 1.4e-08 35.7 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 KPI85825.1 - 7.9e-06 24.8 0.0 1e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Ndr family Peptidase_S9 PF00326.21 KPI85825.1 - 0.00026 20.5 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 KPI85825.1 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Putative esterase FSH1 PF03959.13 KPI85825.1 - 0.0024 17.6 0.0 0.0032 17.2 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Esterase_phd PF10503.9 KPI85825.1 - 0.027 14.0 0.0 6.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_4 PF08386.10 KPI85825.1 - 0.029 14.5 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Amidase PF01425.21 KPI85826.1 - 3.6e-08 32.8 1.0 0.008 15.2 0.0 3.6 4 0 0 4 4 4 3 Amidase DUF3516 PF12029.8 KPI85826.1 - 0.092 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) ACC_epsilon PF13822.6 KPI85826.1 - 1.8 9.3 21.8 0.091 13.5 11.7 2.8 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit PI3_PI4_kinase PF00454.27 KPI85827.1 - 0.0001 22.2 0.0 0.00024 21.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Mak10 PF04112.13 KPI85829.1 - 7.1e-06 25.6 0.1 5.4e-05 22.8 0.1 2.5 2 1 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase E6 PF00518.17 KPI85829.1 - 0.12 12.8 0.2 8.9 6.8 0.0 2.9 2 0 0 2 2 2 0 Early Protein (E6) PDEase_I PF00233.19 KPI85831.1 - 2.9e-12 46.8 0.0 6.4e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Metal_resist PF13801.6 KPI85831.1 - 0.13 12.4 5.0 0.64 10.2 5.0 2.2 1 0 0 1 1 1 0 Heavy-metal resistance PCIF1_WW PF12237.8 KPI85832.1 - 4.9e-33 114.2 0.8 1.6e-31 109.2 0.7 2.8 2 1 0 2 2 2 1 Phosphorylated CTD interacting factor 1 WW domain GDA1_CD39 PF01150.17 KPI85833.1 - 2.8e-78 263.5 0.0 3.5e-78 263.1 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 KPI85833.1 - 0.0029 17.1 0.0 0.0044 16.5 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Lysine_decarbox PF03641.14 KPI85834.1 - 2.4e-24 85.9 0.0 4.3e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 KPI85834.1 - 2.8e-08 33.5 0.0 4.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 SLOG cluster4 family DUF1018 PF06252.12 KPI85834.1 - 0.093 13.7 0.3 0.36 11.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) NAD_binding_1 PF00175.21 KPI85835.1 - 2.1e-27 95.9 0.0 3.8e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KPI85835.1 - 1e-24 86.7 0.0 1.5e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KPI85835.1 - 2.2e-07 31.1 0.0 2.2e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain ChAPs PF09295.10 KPI85835.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) MIF4G PF02854.19 KPI85836.1 - 9.5e-20 71.1 1.0 1.9e-19 70.2 1.0 1.5 1 0 0 1 1 1 1 MIF4G domain CRM1_C PF08767.11 KPI85836.1 - 0.044 12.9 0.1 0.094 11.9 0.1 1.5 1 0 0 1 1 1 0 CRM1 C terminal FSIP1 PF15554.6 KPI85837.1 - 0.015 14.4 0.2 0.036 13.2 0.2 1.6 1 0 0 1 1 1 0 FSIP1 family SlyX PF04102.12 KPI85837.1 - 1.8 9.2 9.2 0.22 12.2 0.3 3.7 3 0 0 3 3 3 0 SlyX PilJ PF13675.6 KPI85837.1 - 4.9 7.2 13.6 7.5 6.6 4.5 3.9 4 0 0 4 4 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term GP57 PF17594.2 KPI85838.1 - 0.18 11.6 0.9 2.7 7.8 0.1 2.5 2 0 0 2 2 2 0 Phage Tail fiber assembly helper gene product 57 AAA_2 PF07724.14 KPI85839.1 - 7e-40 136.9 1.3 1.8e-31 109.6 0.4 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 KPI85839.1 - 1.6e-13 51.2 0.0 6.9e-06 26.5 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KPI85839.1 - 8e-09 35.6 0.3 2.2e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) MCM PF00493.23 KPI85839.1 - 5.4e-06 25.7 0.1 0.00052 19.2 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain AAA_22 PF13401.6 KPI85839.1 - 6.5e-06 26.5 0.0 0.00034 20.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 KPI85839.1 - 2.2e-05 24.0 0.4 0.0046 16.4 0.0 2.9 2 1 1 3 3 3 1 Bacterial TniB protein ClpB_D2-small PF10431.9 KPI85839.1 - 2.6e-05 24.2 0.7 8.1e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_18 PF13238.6 KPI85839.1 - 9.9e-05 22.9 0.2 0.00031 21.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 KPI85839.1 - 0.00014 21.4 0.1 0.0024 17.3 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KPI85839.1 - 0.00027 21.4 0.5 0.00067 20.1 0.4 1.9 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 KPI85839.1 - 0.00047 19.5 0.3 0.0011 18.3 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain NTPase_1 PF03266.15 KPI85839.1 - 0.0014 18.6 1.3 0.6 10.0 0.0 2.6 2 0 0 2 2 2 2 NTPase AAA_14 PF13173.6 KPI85839.1 - 0.002 18.1 0.0 0.87 9.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 KPI85839.1 - 0.002 17.9 0.1 1.3 8.8 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase RuvB_N PF05496.12 KPI85839.1 - 0.0027 17.5 0.1 0.021 14.6 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 KPI85839.1 - 0.0082 15.9 0.4 0.38 10.5 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI85839.1 - 0.011 15.9 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KPI85839.1 - 0.014 15.3 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KPI85839.1 - 0.021 15.1 0.1 0.15 12.3 0.0 2.3 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 KPI85839.1 - 0.021 14.5 0.0 0.066 12.9 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 KPI85839.1 - 0.029 13.7 0.0 0.063 12.5 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 KPI85839.1 - 0.036 14.4 0.6 0.11 12.9 0.6 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KPI85839.1 - 0.044 13.7 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 KPI85839.1 - 0.048 14.2 0.1 0.12 12.9 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 KPI85839.1 - 0.05 13.1 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 KPI85839.1 - 0.051 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein CPT PF07931.12 KPI85839.1 - 0.071 12.9 0.1 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 KPI85839.1 - 0.1 12.5 0.0 3.4 7.5 0.0 2.6 2 1 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 KPI85839.1 - 0.15 12.5 0.0 1 9.8 0.0 2.3 2 1 1 3 3 2 0 RNA helicase AAA_17 PF13207.6 KPI85839.1 - 5.4 7.4 6.9 4.8 7.6 0.3 3.7 3 1 1 4 4 4 0 AAA domain FMO-like PF00743.19 KPI85840.1 - 2.5e-29 102.1 0.0 2.1e-24 85.8 0.0 3.0 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 KPI85840.1 - 4.1e-13 49.2 0.0 9.9e-13 48.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KPI85840.1 - 4.3e-10 39.3 1.0 3.9e-05 23.1 0.1 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KPI85840.1 - 1.8e-06 27.4 0.1 3.2e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KPI85840.1 - 3.2e-05 24.1 0.0 0.00015 21.9 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KPI85840.1 - 0.00026 21.5 0.1 0.3 11.7 0.0 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.12 KPI85840.1 - 0.0025 17.4 0.2 0.62 9.6 0.0 2.3 2 0 0 2 2 2 2 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_9 PF13454.6 KPI85840.1 - 0.0095 15.9 0.1 0.11 12.5 0.1 2.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 KPI85840.1 - 0.037 12.7 0.6 0.055 12.2 0.6 1.2 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 KPI85840.1 - 0.065 12.5 1.6 5.8 6.2 0.1 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 KPI85840.1 - 0.074 12.6 0.9 28 4.2 0.2 3.2 3 0 0 3 3 3 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 KPI85840.1 - 0.16 12.5 0.2 1.8 9.1 0.0 2.6 3 0 0 3 3 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 KPI85840.1 - 0.2 10.7 2.9 0.27 10.3 0.8 2.0 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 KPI85840.1 - 0.22 10.7 0.2 0.49 9.6 0.2 1.6 2 0 0 2 2 2 0 Thi4 family GIDA PF01134.22 KPI85840.1 - 1.3 8.0 3.9 1.8 7.6 1.5 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Mito_carr PF00153.27 KPI85842.1 - 5.4e-43 144.8 1.0 3.5e-15 55.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DEAD PF00270.29 KPI85843.1 - 4e-40 137.4 0.1 8.4e-40 136.4 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI85843.1 - 2e-27 95.7 6.0 5.8e-25 87.8 0.1 3.9 3 1 1 4 4 4 2 Helicase conserved C-terminal domain zf-CCCH PF00642.24 KPI85844.1 - 1.1e-07 31.6 2.4 1.1e-07 31.6 2.4 2.4 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) oligo_HPY PF08352.12 KPI85844.1 - 0.18 12.3 4.7 0.38 11.3 0.4 2.5 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region zf_CCCH_4 PF18345.1 KPI85844.1 - 7.1 6.8 7.4 2.4 8.4 1.7 3.0 2 1 0 2 2 2 0 Zinc finger domain SH3-WW_linker PF16618.5 KPI85845.1 - 0.0043 17.6 0.6 0.0043 17.6 0.6 1.6 2 0 0 2 2 2 1 Linker region between SH3 and WW domains on ARHGAP12 zf-CCCH_4 PF18044.1 KPI85846.1 - 1.6e-06 27.7 1.2 3.1e-06 26.9 1.2 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 KPI85846.1 - 1.3e-05 24.9 2.8 2.4e-05 24.1 2.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI85846.1 - 0.0057 16.7 1.4 0.011 15.8 1.4 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 KPI85846.1 - 0.024 15.1 2.8 0.024 15.1 2.8 1.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger PP2C PF00481.21 KPI85847.1 - 7.8e-67 225.6 0.1 7.8e-67 225.6 0.1 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 KPI85847.1 - 0.0011 18.7 0.6 0.0029 17.3 0.0 2.0 2 1 0 2 2 2 1 Protein phosphatase 2C S_100 PF01023.19 KPI85847.1 - 0.11 12.2 0.1 0.68 9.7 0.1 2.2 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain VSG_B PF13206.6 KPI85847.1 - 0.34 10.1 7.4 5.1 6.2 0.0 2.2 1 1 1 2 2 2 0 Trypanosomal VSG domain Pkinase PF00069.25 KPI85848.1 - 4.1e-44 150.9 0.0 5.7e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85848.1 - 2.9e-15 56.3 0.0 9.5e-15 54.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KPI85848.1 - 0.00048 20.1 0.2 0.0032 17.4 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KPI85848.1 - 0.0032 17.1 0.0 0.0051 16.4 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase PIP49_C PF12260.8 KPI85848.1 - 0.075 12.7 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Cyt-b5 PF00173.28 KPI85850.1 - 1.3e-07 31.6 0.0 2.1e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Peptidase_M50B PF13398.6 KPI85851.1 - 0.12 12.0 1.2 0.17 11.5 1.2 1.1 1 0 0 1 1 1 0 Peptidase M50B-like Antimicrobial18 PF08130.11 KPI85852.1 - 0.21 11.7 0.3 0.7 10.0 0.3 1.9 1 0 0 1 1 1 0 Type A lantibiotic family Ubiquitin_2 PF14560.6 KPI85853.1 - 1.2e-23 83.4 0.0 2.4e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain CAP_GLY PF01302.25 KPI85853.1 - 2.4e-20 72.3 0.7 3.8e-20 71.7 0.7 1.3 1 0 0 1 1 1 1 CAP-Gly domain ubiquitin PF00240.23 KPI85853.1 - 0.028 14.2 0.0 0.31 10.8 0.0 2.3 1 1 0 1 1 1 0 Ubiquitin family WD40 PF00400.32 KPI85854.1 - 4.5e-42 141.2 16.7 2.4e-06 28.2 0.3 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI85854.1 - 3.2e-12 46.6 3.1 0.058 13.7 0.1 5.5 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KPI85854.1 - 0.005 15.8 6.6 0.25 10.2 0.3 3.2 1 1 2 3 3 3 3 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 KPI85854.1 - 0.034 12.8 0.2 1.5 7.3 0.0 2.5 2 1 0 2 2 2 0 Nucleoporin Nup120/160 PSD4 PF07631.11 KPI85854.1 - 0.088 13.3 0.9 0.29 11.7 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) UDG PF03167.19 KPI85855.1 - 8.5e-20 71.3 0.0 1.4e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily BTB_2 PF02214.22 KPI85856.1 - 3.9e-10 40.0 0.0 5.7e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain PPR_3 PF13812.6 KPI85857.1 - 0.0031 17.5 0.0 0.38 10.9 0.0 3.5 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.20 KPI85857.1 - 0.18 12.1 0.5 1.1e+02 3.4 0.0 4.1 5 0 0 5 5 5 0 PPR repeat Aconitase PF00330.20 KPI85858.1 - 1.1e-179 598.3 0.0 1.5e-179 597.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KPI85858.1 - 2.3e-42 144.4 0.0 4.6e-42 143.4 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Lectin_N PF03954.14 KPI85859.1 - 0.24 11.2 9.9 0.41 10.4 1.2 3.6 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain CENP-H PF05837.12 KPI85859.1 - 1.3 9.4 27.1 0.55 10.7 2.3 3.7 3 0 0 3 3 3 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 KPI85859.1 - 2.4 7.4 21.2 4.4 6.6 2.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Strep_SA_rep PF06696.11 KPI85859.1 - 2.6 8.1 5.8 30 4.8 4.3 2.4 2 0 0 2 2 2 0 Streptococcal surface antigen repeat UPF0242 PF06785.11 KPI85859.1 - 3.1 7.8 17.8 2.5 8.2 9.3 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 KPI85859.1 - 9.7 6.9 11.4 1.6 9.4 0.1 3.2 3 1 0 3 3 3 0 Initiation control protein YabA TBCC PF07986.12 KPI85860.1 - 7.2e-33 112.9 0.2 1.2e-32 112.2 0.2 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C LisH_2 PF16045.5 KPI85860.1 - 0.0032 16.4 0.1 0.0076 15.3 0.1 1.7 1 0 0 1 1 1 1 LisH CAP_C PF08603.11 KPI85860.1 - 0.11 12.1 0.2 0.19 11.3 0.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal TMEM135_C_rich PF15982.5 KPI85861.1 - 2.1e-05 25.2 3.0 2.3e-05 25.0 1.2 2.0 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 DUF872 PF05915.12 KPI85861.1 - 0.13 12.5 0.2 0.97 9.6 0.1 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) GBP_C PF02841.14 KPI85862.1 - 0.16 11.3 10.5 0.24 10.7 10.5 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Methyltransf_32 PF13679.6 KPI85862.1 - 0.29 11.1 2.2 0.56 10.2 2.2 1.4 1 0 0 1 1 1 0 Methyltransferase domain V-ATPase_C PF03223.15 KPI85863.1 - 8.1e-84 282.1 0.7 9.7e-84 281.9 0.7 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Ubiquitin_2 PF14560.6 KPI85863.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain ASH PF15780.5 KPI85864.1 - 2.3e-11 43.7 7.0 0.00018 21.6 0.1 5.8 5 1 0 5 5 5 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 KPI85864.1 - 3.9e-08 33.1 2.0 0.0052 16.6 0.0 4.0 4 0 0 4 4 4 3 MSP (Major sperm protein) domain TMEM131_like PF12371.8 KPI85864.1 - 3.3e-07 30.5 3.4 1.3 9.4 0.0 4.9 5 0 0 5 5 5 3 Transmembrane protein 131-like MYCBPAP PF14646.6 KPI85864.1 - 1.9e-05 23.8 0.0 0.032 13.2 0.0 2.8 2 1 1 3 3 3 2 MYCBP-associated protein family PapD-like PF14874.6 KPI85864.1 - 0.00041 20.5 1.2 0.27 11.4 0.3 3.1 3 0 0 3 3 3 2 Flagellar-associated PapD-like PapD_N PF00345.20 KPI85864.1 - 0.00099 19.0 0.1 0.17 11.8 0.0 3.4 4 0 0 4 4 4 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain DUF5001 PF16392.5 KPI85864.1 - 0.0093 15.9 0.9 2.2 8.2 0.0 3.8 4 0 0 4 4 4 1 Ig-like domain fn3_5 PF06280.12 KPI85864.1 - 0.082 13.6 1.9 29 5.4 0.0 4.0 4 0 0 4 4 4 0 Fn3-like domain Nup_retrotrp_bd PF10599.9 KPI85864.1 - 0.091 13.4 0.4 0.31 11.7 0.4 1.9 1 0 0 1 1 1 0 Retro-transposon transporting motif MAM33 PF02330.16 KPI85864.1 - 0.15 12.0 0.1 11 5.9 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial glycoprotein ECH_1 PF00378.20 KPI85865.1 - 8.7e-37 126.8 0.1 2.7e-35 121.9 0.1 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI85865.1 - 4.4e-13 49.5 0.1 7.7e-11 42.1 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ATP_Ca_trans_C PF12424.8 KPI85865.1 - 0.013 15.9 0.1 0.027 14.9 0.1 1.5 1 0 0 1 1 1 0 Plasma membrane calcium transporter ATPase C terminal Pribosyltran PF00156.27 KPI85865.1 - 0.035 13.6 0.1 1.8 8.0 0.0 2.2 1 1 1 2 2 2 0 Phosphoribosyl transferase domain RRM_1 PF00076.22 KPI85866.1 - 5e-18 64.7 0.0 9.1e-18 63.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI85866.1 - 0.023 14.7 0.0 0.073 13.1 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KPI85866.1 - 0.032 14.4 0.8 0.1 12.7 0.0 2.5 3 1 0 3 3 3 0 RNA recognition motif gerPA PF10676.9 KPI85866.1 - 0.17 12.2 6.1 0.055 13.7 1.6 2.6 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF S36_mt PF10937.8 KPI85867.1 - 5.4e-05 24.8 0.0 9.8e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial zf-C2HC_2 PF13913.6 KPI85868.1 - 5.1e-26 90.0 17.3 3.2e-09 36.5 1.0 3.5 3 0 0 3 3 3 3 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.6 KPI85868.1 - 0.00065 19.0 1.4 0.00065 19.0 1.4 3.4 4 0 0 4 4 4 2 zinc-ribbon domain zf-RING_7 PF02591.15 KPI85868.1 - 0.0051 17.0 9.7 0.44 10.8 0.1 4.1 3 1 1 4 4 4 2 C4-type zinc ribbon domain DZR PF12773.7 KPI85868.1 - 0.0061 16.6 0.6 0.0061 16.6 0.6 4.1 4 0 0 4 4 4 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 KPI85868.1 - 0.099 13.4 4.7 0.33 11.7 0.1 3.5 4 0 0 4 4 4 0 zinc-ribbon family zf-CHCC PF10276.9 KPI85868.1 - 0.1 12.7 3.1 3.2 7.9 0.2 3.6 3 0 0 3 3 3 0 Zinc-finger domain PyrI_C PF02748.15 KPI85868.1 - 0.12 12.3 1.5 0.22 11.5 0.0 2.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.6 KPI85868.1 - 0.22 12.5 17.1 1 10.3 0.1 4.5 4 1 1 5 5 4 0 C2H2-type zinc finger Rad50_zn_hook PF04423.14 KPI85868.1 - 0.31 10.9 2.8 4.4 7.2 0.0 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif C1_2 PF03107.16 KPI85868.1 - 0.43 10.9 4.5 5.9 7.3 0.4 3.4 4 0 0 4 4 3 0 C1 domain zinc_ribbon_2 PF13240.6 KPI85868.1 - 0.54 10.1 22.6 0.31 10.8 7.5 4.3 3 1 1 4 4 4 0 zinc-ribbon domain zf_UBZ PF18439.1 KPI85868.1 - 0.86 9.3 7.6 6.5 6.4 0.0 4.0 3 1 1 4 4 4 0 Ubiquitin-Binding Zinc Finger NOB1_Zn_bind PF08772.11 KPI85868.1 - 1.5 9.0 6.1 7.8 6.7 3.5 2.7 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF2318 PF10080.9 KPI85868.1 - 1.9 8.6 9.9 2.7 8.2 0.2 3.7 4 0 0 4 4 4 0 Predicted membrane protein (DUF2318) RNase_PH_C PF03725.15 KPI85869.1 - 1.3e-07 31.6 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.21 KPI85869.1 - 5.2e-06 27.0 0.0 9.1e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RRM_1 PF00076.22 KPI85870.1 - 7.1e-09 35.4 0.0 2.4e-06 27.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AF-4 PF05110.13 KPI85870.1 - 0.054 11.6 15.8 0.084 11.0 15.8 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 KPI85870.1 - 0.39 9.2 4.0 0.54 8.8 4.0 1.1 1 0 0 1 1 1 0 Macoilin family Cwf_Cwc_15 PF04889.12 KPI85870.1 - 1.2 8.8 8.6 1.9 8.2 8.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NPR3 PF03666.13 KPI85870.1 - 2.5 6.8 5.0 3.6 6.3 5.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 KPI85870.1 - 2.6 6.8 6.3 3.8 6.2 6.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 KPI85870.1 - 3.3 5.9 9.0 4.6 5.4 9.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SDP_N PF12278.8 KPI85870.1 - 6.3 6.9 7.8 12 6.1 7.8 1.4 1 0 0 1 1 1 0 Sex determination protein N terminal TPR_19 PF14559.6 KPI85871.1 - 0.0015 19.0 0.4 0.45 11.1 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KPI85871.1 - 0.011 16.3 16.5 0.076 13.7 1.3 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KPI85871.1 - 0.017 15.4 0.3 8.6 7.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI85871.1 - 0.35 11.8 11.1 56 4.9 0.1 5.9 5 1 1 6 6 6 0 Tetratricopeptide repeat DEAD PF00270.29 KPI85873.1 - 4.4e-18 65.7 0.0 1.8e-17 63.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI85873.1 - 0.00011 22.5 0.0 0.00028 21.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI85873.1 - 0.00043 20.3 0.0 0.00078 19.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KPI85873.1 - 0.01 16.1 0.0 5.6 7.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KPI85873.1 - 0.013 15.9 0.0 0.49 10.8 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KPI85873.1 - 0.025 14.1 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 KPI85873.1 - 0.091 12.5 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KPI85873.1 - 0.13 12.6 0.1 1.3 9.3 0.1 2.5 1 1 0 1 1 1 0 AAA domain Torus PF16131.5 KPI85874.1 - 0.0082 16.8 6.7 1.1 9.9 0.2 2.6 2 0 0 2 2 2 2 Torus domain zf-CCCH PF00642.24 KPI85874.1 - 0.014 15.3 18.7 0.33 10.9 3.5 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KPI85874.1 - 0.77 10.3 15.6 2.5 8.7 5.2 3.6 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 KPI85874.1 - 7 6.6 16.8 10 6.0 3.7 2.7 2 0 0 2 2 2 0 CCCH-type zinc finger IMUP PF15761.5 KPI85876.1 - 1.8 9.3 12.7 0.21 12.3 7.6 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein FAM199X PF15814.5 KPI85876.1 - 3.3 6.7 7.9 5.4 6.0 7.9 1.4 1 0 0 1 1 1 0 Protein family FAM199X Robl_LC7 PF03259.17 KPI85877.1 - 1e-05 25.2 0.1 0.0002 21.1 0.0 2.0 2 0 0 2 2 2 2 Roadblock/LC7 domain Methyltr_RsmB-F PF01189.17 KPI85879.1 - 0.0033 17.1 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F ERM PF00769.19 KPI85881.1 - 0.011 15.5 5.8 0.017 15.0 5.8 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CENP-H PF05837.12 KPI85881.1 - 0.064 13.7 6.2 0.22 12.0 0.8 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF4140 PF13600.6 KPI85881.1 - 0.19 12.2 6.6 0.32 11.4 0.2 2.7 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) APG6_N PF17675.1 KPI85881.1 - 0.74 10.4 10.1 1.6 9.3 3.6 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region PH PF00169.29 KPI85883.1 - 2.3e-05 24.8 0.0 7e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 PH domain PH_13 PF16652.5 KPI85883.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain ECH_2 PF16113.5 KPI85886.1 - 2.4e-89 300.1 0.0 2.8e-89 299.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KPI85886.1 - 5.3e-19 68.5 0.0 8e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI85887.1 - 6.5e-102 341.4 0.0 7.3e-102 341.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KPI85887.1 - 1.2e-25 90.2 0.0 3.8e-24 85.4 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase zinc_ribbon_2 PF13240.6 KPI85888.1 - 0.00087 18.9 2.5 0.0019 17.9 2.5 1.5 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 KPI85888.1 - 0.0025 17.2 2.2 0.0053 16.1 2.2 1.5 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 KPI85888.1 - 0.0088 16.1 0.4 0.02 14.9 0.4 1.5 1 0 0 1 1 1 1 Double zinc ribbon DUF1151 PF06625.11 KPI85889.1 - 0.23 11.4 6.6 0.25 11.3 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) DUF4674 PF15719.5 KPI85890.1 - 0.01 15.9 3.2 0.01 15.9 3.2 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4674) DUF2614 PF11023.8 KPI85890.1 - 0.083 13.0 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain DUF2062 PF09835.9 KPI85891.1 - 0.00019 21.3 7.1 0.00024 21.0 7.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2062) NifU PF01106.17 KPI85892.1 - 1.2e-25 89.4 0.0 3.3e-25 88.0 0.0 1.8 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 KPI85892.1 - 2.4e-22 78.8 0.0 4e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal Amidohydro_1 PF01979.20 KPI85892.1 - 0.055 12.8 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase family eRF1_1 PF03463.15 KPI85893.1 - 3.6e-29 101.4 0.1 8.6e-29 100.2 0.1 1.7 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 KPI85893.1 - 5.5e-18 65.6 0.2 8.9e-18 64.9 0.2 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KPI85893.1 - 8.5e-13 48.8 0.0 3.6e-12 46.8 0.0 2.1 2 0 0 2 2 2 1 eRF1 domain 3 DUF334 PF03904.13 KPI85893.1 - 0.0036 16.9 0.2 0.0058 16.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF334) baeRF_family3 PF18845.1 KPI85893.1 - 0.0081 16.4 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 3 SIR2 PF02146.17 KPI85894.1 - 3.1e-56 190.1 0.0 4e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Zn-ribbon_8 PF09723.10 KPI85894.1 - 0.17 12.0 0.4 0.43 10.7 0.4 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF364 PF04016.12 KPI85894.1 - 0.19 11.3 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 Putative heavy-metal chelation LIDHydrolase PF10230.9 KPI85895.1 - 2.9e-60 204.1 0.0 3.3e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 KPI85895.1 - 1.8e-11 43.8 0.0 2.2e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI85895.1 - 3.5e-08 34.3 0.1 4.4e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KPI85895.1 - 8.2e-07 28.9 0.0 2.4e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 KPI85895.1 - 7.6e-05 22.9 0.1 0.00016 21.9 0.0 1.5 2 0 0 2 2 2 1 Thioesterase domain PGAP1 PF07819.13 KPI85895.1 - 0.0066 16.2 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein LTXXQ PF07813.12 KPI85896.1 - 0.12 13.1 3.3 3.4 8.4 0.2 3.2 3 0 0 3 3 3 0 LTXXQ motif family protein IF4E PF01652.18 KPI85897.1 - 5.9e-12 45.7 0.0 7.4e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E EccE PF11203.8 KPI85898.1 - 0.51 10.7 0.0 0.51 10.7 0.0 3.6 4 0 0 4 4 4 0 Putative type VII ESX secretion system translocon, EccE DUF3993 PF13158.6 KPI85899.1 - 0.083 13.1 0.0 0.29 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) MMR_HSR1 PF01926.23 KPI85900.1 - 2.7e-45 153.1 0.0 3.5e-21 75.4 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI85900.1 - 3e-26 92.2 0.8 9.8e-15 54.6 0.0 3.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KPI85900.1 - 3.9e-21 75.2 0.1 1.1e-09 38.1 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.23 KPI85900.1 - 9.5e-19 68.1 0.0 0.00043 20.4 0.0 4.4 3 1 1 4 4 4 3 Dynamin family Roc PF08477.13 KPI85900.1 - 6.9e-14 52.1 0.0 7e-06 26.3 0.0 3.2 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KPI85900.1 - 1.5e-13 51.0 0.2 0.0026 17.7 0.0 4.3 2 1 2 4 4 4 3 RsgA GTPase AIG1 PF04548.16 KPI85900.1 - 1.6e-13 50.5 0.0 1.8e-06 27.5 0.0 2.7 3 0 0 3 3 3 2 AIG1 family KH_dom-like PF14714.6 KPI85900.1 - 1.1e-12 48.1 0.5 4.2e-12 46.2 0.3 2.1 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal SRPRB PF09439.10 KPI85900.1 - 3.4e-11 42.9 0.0 4.3e-05 23.0 0.0 2.5 2 1 0 2 2 2 2 Signal recognition particle receptor beta subunit Ras PF00071.22 KPI85900.1 - 9.5e-11 41.6 0.0 6.9e-06 25.7 0.0 2.9 2 1 0 2 2 2 2 Ras family Arf PF00025.21 KPI85900.1 - 8e-07 28.7 0.5 0.054 12.9 0.0 3.5 2 2 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 KPI85900.1 - 8.4e-07 29.0 0.1 0.0089 16.0 0.0 2.6 2 0 0 2 2 2 2 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 KPI85900.1 - 3.5e-06 27.6 0.0 0.088 13.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Septin PF00735.18 KPI85900.1 - 5.7e-06 25.8 0.0 0.0013 18.1 0.0 2.4 2 0 0 2 2 2 1 Septin PduV-EutP PF10662.9 KPI85900.1 - 2.7e-05 24.0 0.0 0.56 10.0 0.0 3.4 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 KPI85900.1 - 3.6e-05 23.4 1.0 0.18 11.4 0.2 3.9 3 1 1 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 KPI85900.1 - 0.00018 20.7 0.0 0.015 14.3 0.0 2.4 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) TniB PF05621.11 KPI85900.1 - 0.00026 20.5 0.0 0.023 14.1 0.0 2.7 3 0 0 3 3 3 1 Bacterial TniB protein GBP PF02263.19 KPI85900.1 - 0.00099 18.4 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 Guanylate-binding protein, N-terminal domain G-alpha PF00503.20 KPI85900.1 - 0.0018 17.5 0.2 0.73 8.9 0.0 2.9 3 1 0 3 3 3 1 G-protein alpha subunit MobB PF03205.14 KPI85900.1 - 0.0021 18.0 0.0 0.18 11.7 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.6 KPI85900.1 - 0.0052 16.5 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KPI85900.1 - 0.0073 16.2 0.0 1.9 8.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI85900.1 - 0.0089 16.5 0.2 8.3 6.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain CLP1_P PF16575.5 KPI85900.1 - 0.018 14.8 0.7 16 5.2 0.0 3.6 2 1 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 KPI85900.1 - 0.024 15.2 0.0 7.3 7.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KPI85900.1 - 0.031 14.5 0.2 22 5.3 0.0 3.8 3 1 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 KPI85900.1 - 0.033 14.1 0.0 2.3 8.0 0.0 2.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 KPI85900.1 - 0.041 13.2 0.0 4.2 6.7 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 KPI85900.1 - 0.076 12.1 0.0 0.39 9.7 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein dNK PF01712.19 KPI85900.1 - 0.096 12.5 0.0 1 9.2 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_24 PF13479.6 KPI85900.1 - 0.12 12.1 0.0 14 5.3 0.0 2.8 3 0 0 3 3 2 0 AAA domain MethyTransf_Reg PF10119.9 KPI85901.1 - 0.016 15.9 0.9 0.1 13.3 0.1 2.7 1 1 1 3 3 3 0 Predicted methyltransferase regulatory domain NUDIX_2 PF13869.6 KPI85902.1 - 4.1e-40 137.4 0.0 1.2e-38 132.6 0.0 2.5 1 1 0 1 1 1 1 Nucleotide hydrolase 6PF2K PF01591.18 KPI85903.1 - 4.4e-30 104.6 0.0 6.6e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KPI85903.1 - 1.1e-13 51.4 0.0 3e-08 33.6 0.0 2.3 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Ank_5 PF13857.6 KPI85903.1 - 2.4e-12 46.8 0.1 6.2e-12 45.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI85903.1 - 4.8e-12 46.3 0.0 1.7e-11 44.5 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI85903.1 - 9.2e-09 35.7 0.0 4.6e-06 27.1 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI85903.1 - 8e-08 32.4 0.3 0.00037 20.8 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KPI85903.1 - 5e-07 29.5 0.0 2.4e-05 24.3 0.1 3.4 3 0 0 3 3 3 1 Ankyrin repeat AAA_33 PF13671.6 KPI85903.1 - 4.4e-05 23.7 0.0 9.8e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 KPI85903.1 - 0.00036 20.1 0.0 0.00094 18.7 0.0 1.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_19 PF13245.6 KPI85903.1 - 0.0011 19.3 0.0 0.0036 17.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI85903.1 - 0.0033 17.4 0.0 0.0082 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KPI85903.1 - 0.042 13.2 0.4 0.1 11.9 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 KPI85903.1 - 0.08 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain APS_kinase PF01583.20 KPI85903.1 - 0.098 12.5 0.1 4.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_17 PF13207.6 KPI85903.1 - 0.13 12.7 0.1 1.1 9.7 0.1 2.3 1 1 0 1 1 1 0 AAA domain THF_DHG_CYH_C PF02882.19 KPI85904.1 - 5.8e-48 162.2 1.3 9.2e-48 161.6 0.5 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KPI85904.1 - 2.2e-31 108.5 0.2 3.1e-31 108.1 0.2 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Cyclin_N PF00134.23 KPI85905.1 - 1.4e-10 41.0 0.2 3.6e-10 39.7 0.2 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KPI85905.1 - 4e-05 23.7 0.6 0.00015 21.8 0.6 2.1 1 1 0 1 1 1 1 Cyclin, C-terminal domain YbhQ PF11076.8 KPI85905.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ IU_nuc_hydro PF01156.19 KPI85906.1 - 3.8e-17 62.8 0.4 5.2e-17 62.4 0.4 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Cytochrom_C_asm PF01578.20 KPI85906.1 - 0.0077 16.0 1.4 0.036 13.8 1.5 1.9 1 1 0 1 1 1 1 Cytochrome C assembly protein Vps52 PF04129.12 KPI85907.1 - 4.5e-50 170.9 3.8 1.1e-18 67.2 0.1 3.6 3 1 0 3 3 3 3 Vps52 / Sac2 family DASH_Duo1 PF08651.10 KPI85907.1 - 0.11 12.3 0.4 1.7 8.5 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 TPR_2 PF07719.17 KPI85909.1 - 1.3e-30 103.0 30.5 0.00057 19.8 0.1 15.2 16 0 0 16 16 16 6 Tetratricopeptide repeat TPR_1 PF00515.28 KPI85909.1 - 3.7e-26 89.8 26.8 7.1e-05 22.5 0.1 13.2 16 0 0 16 16 15 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85909.1 - 2e-22 79.2 44.1 3.7e-05 23.9 0.7 11.3 10 3 1 11 11 11 7 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85909.1 - 8.6e-20 69.3 16.2 0.0011 19.0 0.0 11.5 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI85909.1 - 2.5e-14 53.2 33.4 0.037 14.2 0.7 10.6 6 4 6 12 12 12 4 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85909.1 - 4.1e-11 43.2 24.7 0.47 11.0 0.0 10.0 9 2 2 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 KPI85909.1 - 3e-10 40.6 42.8 0.0024 18.5 0.1 10.8 10 1 2 12 12 11 4 Tetratricopeptide repeat TPR_10 PF13374.6 KPI85909.1 - 1.9e-06 27.5 26.9 2.1 8.4 0.6 10.2 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI85909.1 - 4.7e-05 23.9 36.7 7.3 7.7 0.0 13.4 10 3 5 15 15 14 1 Tetratricopeptide repeat TPR_17 PF13431.6 KPI85909.1 - 0.00017 21.7 25.0 7 7.3 0.2 9.7 13 1 0 13 13 11 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI85909.1 - 0.00026 20.6 17.4 2.1 8.1 0.0 9.4 12 1 1 13 13 12 1 TPR repeat NARP1 PF12569.8 KPI85909.1 - 0.00057 18.9 0.1 7.2 5.4 0.0 3.8 3 1 0 3 3 3 1 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.6 KPI85909.1 - 0.0049 16.9 2.7 14 5.8 0.4 5.1 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 KPI85909.1 - 0.017 15.7 23.5 29 5.7 3.3 9.5 8 0 0 8 8 8 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 KPI85909.1 - 0.022 14.2 9.3 28 4.3 0.1 6.4 7 0 0 7 7 7 0 SHNi-TPR TPR_7 PF13176.6 KPI85909.1 - 0.053 13.6 23.4 1.2 9.3 0.0 8.9 11 1 0 11 11 10 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI85909.1 - 0.3 11.3 18.4 5.6 7.3 0.0 7.0 7 2 2 9 9 9 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 KPI85909.1 - 0.88 9.2 5.7 2.4 7.8 3.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 KPI85909.1 - 1.7 9.4 21.2 1.4e+02 3.4 0.1 8.9 9 0 0 9 9 9 0 Tetratricopeptide repeat Ist1 PF03398.14 KPI85910.1 - 1.5e-44 151.8 0.1 1.8e-44 151.5 0.1 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Ret2_MD PF18528.1 KPI85911.1 - 5.8e-47 158.0 0.2 1.1e-46 157.2 0.2 1.4 1 0 0 1 1 1 1 RNA editing 3' terminal uridylyl transferase 2 middle domain PAP_assoc PF03828.19 KPI85911.1 - 7.4e-17 61.3 0.1 1.5e-16 60.3 0.1 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KPI85911.1 - 2.7e-05 24.4 0.0 7.6e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain DUF2967 PF11179.8 KPI85911.1 - 0.051 11.7 0.0 0.087 10.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2967) Polbeta PF18765.1 KPI85911.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase 2OG-FeII_Oxy_2 PF13532.6 KPI85912.1 - 3.6e-15 56.7 0.0 5.6e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pan_kinase PF03309.14 KPI85912.1 - 0.14 11.9 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Type III pantothenate kinase SKA2 PF16740.5 KPI85913.1 - 0.017 14.9 0.0 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF1091 PF06477.13 KPI85913.1 - 0.096 13.2 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) zf-B_box PF00643.24 KPI85913.1 - 0.47 10.6 13.4 0.3 11.3 7.1 2.8 3 0 0 3 3 3 0 B-box zinc finger PseudoU_synth_1 PF01416.20 KPI85914.1 - 2e-06 28.3 0.0 4.1e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase ParA PF10609.9 KPI85915.1 - 6.5e-94 314.0 0.0 9.8e-92 306.8 0.0 2.0 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KPI85915.1 - 2.4e-11 43.8 0.0 1.1e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KPI85915.1 - 7.3e-07 29.3 0.1 2.9e-06 27.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 KPI85915.1 - 2.4e-06 27.0 0.1 2e-05 24.0 0.1 2.3 3 0 0 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 KPI85915.1 - 6.9e-06 25.5 0.1 0.00015 21.1 0.1 2.2 1 1 1 2 2 2 1 ATPase MipZ AAA_25 PF13481.6 KPI85915.1 - 0.00039 20.0 0.1 0.00098 18.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 KPI85915.1 - 0.0088 15.5 0.0 0.028 13.9 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NB-ARC PF00931.22 KPI85915.1 - 0.052 12.7 0.1 0.093 11.9 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.20 KPI85915.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase NACHT PF05729.12 KPI85915.1 - 0.057 13.3 0.3 0.13 12.1 0.3 1.6 1 0 0 1 1 1 0 NACHT domain MeaB PF03308.16 KPI85915.1 - 0.088 11.8 0.1 0.15 11.0 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 KPI85915.1 - 0.12 11.9 0.2 0.3 10.5 0.1 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ RsgA_GTPase PF03193.16 KPI85915.1 - 0.15 11.9 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase Patatin PF01734.22 KPI85916.1 - 1.1e-11 45.4 0.6 1.8e-10 41.3 0.6 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase Thioredoxin PF00085.20 KPI85918.1 - 0.0039 17.1 0.0 0.0069 16.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin PTEN_C2 PF10409.9 KPI85919.1 - 5.4e-05 22.9 0.0 9.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 KPI85919.1 - 0.00023 21.0 0.0 0.00039 20.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KPI85919.1 - 0.00032 20.7 0.0 0.00055 20.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KPI85919.1 - 0.00055 20.1 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 KPI85919.1 - 0.0017 18.1 0.0 0.0044 16.7 0.0 1.7 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 KPI85919.1 - 0.026 14.1 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 KPI85919.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF1905 PF08922.11 KPI85920.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1905) EF-hand_7 PF13499.6 KPI85921.1 - 8.8e-16 58.1 0.1 0.0045 17.4 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 KPI85921.1 - 1.3e-12 46.3 0.0 0.72 9.5 0.0 7.4 7 0 0 7 7 7 4 EF hand EF-hand_6 PF13405.6 KPI85921.1 - 1.4e-11 43.3 1.3 1.1 9.4 0.0 7.6 7 1 1 8 8 8 4 EF-hand domain EF-hand_8 PF13833.6 KPI85921.1 - 4.2e-09 36.1 0.2 0.24 11.3 0.0 6.1 6 1 0 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.6 KPI85921.1 - 1.2e-06 27.7 8.8 0.082 12.4 0.0 5.6 8 0 0 8 8 8 3 EF hand KleE PF17394.2 KPI85922.1 - 0.12 12.6 2.7 0.2 11.9 2.1 1.6 1 1 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Spc7 PF08317.11 KPI85923.1 - 0.0059 15.5 13.0 0.0059 15.5 13.0 1.6 2 0 0 2 2 2 1 Spc7 kinetochore protein ADIP PF11559.8 KPI85923.1 - 0.0079 16.3 18.4 0.0079 16.3 18.4 1.4 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding DASH_Spc19 PF08287.11 KPI85923.1 - 0.44 10.4 15.6 0.042 13.7 11.1 1.6 2 0 0 2 2 2 0 Spc19 LMBR1 PF04791.16 KPI85923.1 - 2.4 7.0 3.9 2.3 7.0 3.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein NDK PF00334.19 KPI85924.1 - 8.9e-14 51.7 0.0 4.3e-13 49.4 0.0 2.0 2 0 0 2 2 2 1 Nucleoside diphosphate kinase MukE PF04288.13 KPI85924.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 MukE-like family LRR_6 PF13516.6 KPI85925.1 - 0.047 13.8 0.1 0.14 12.3 0.1 1.8 1 0 0 1 1 1 0 Leucine Rich repeat DUF3813 PF12758.7 KPI85925.1 - 0.13 12.6 1.4 0.36 11.2 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) DUF2524 PF10732.9 KPI85925.1 - 0.24 11.7 1.4 0.45 10.8 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) Rhodanese PF00581.20 KPI85927.1 - 2.7e-11 43.9 0.0 5.7e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 KPI85928.1 - 3.9e-19 69.0 0.0 2.7e-18 66.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 KPI85928.1 - 0.0075 15.1 0.1 0.019 13.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase RMP PF14996.6 KPI85929.1 - 2.6e-07 31.0 11.6 4.5e-06 27.0 9.8 2.9 2 1 0 2 2 2 1 Retinal Maintenance zinc_ribbon_12 PF11331.8 KPI85929.1 - 0.13 12.1 0.3 0.13 12.1 0.3 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain Beta_helix PF13229.6 KPI85930.1 - 5.3e-05 23.1 0.0 0.27 11.1 0.0 2.4 2 0 0 2 2 2 2 Right handed beta helix region Adeno_E1B_55K PF01696.17 KPI85930.1 - 0.027 13.2 2.0 0.061 12.0 2.0 1.5 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen Cyt-b5 PF00173.28 KPI85931.1 - 2.4e-05 24.4 0.1 4.2e-05 23.6 0.1 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain InaF-motif PF15018.6 KPI85931.1 - 0.31 10.9 2.1 0.56 10.1 2.1 1.4 1 0 0 1 1 1 0 TRP-interacting helix Mito_carr PF00153.27 KPI85932.1 - 3.1e-58 193.7 4.5 1.6e-23 82.4 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein MGC-24 PF05283.11 KPI85932.1 - 3.6 8.0 4.7 2.2 8.7 0.5 2.1 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF2269 PF10027.9 KPI85933.1 - 0.036 14.1 1.8 0.082 13.0 1.8 1.6 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) DNA_pol_A_exo1 PF01612.20 KPI85934.1 - 1.2e-38 132.6 0.3 2.6e-38 131.5 0.2 1.6 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 KPI85934.1 - 6e-22 78.1 0.2 3e-20 72.7 0.1 2.5 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 KPI85934.1 - 1.7e-09 37.5 0.0 3.5e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Pup PF05639.11 KPI85934.1 - 0.5 11.3 2.5 0.54 11.2 0.1 2.3 2 0 0 2 2 2 0 Pup-like protein PIP5K PF01504.18 KPI85935.1 - 4.9e-73 245.7 0.0 7.6e-73 245.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Sec15 PF04091.12 KPI85935.1 - 0.15 11.4 0.2 0.41 10.0 0.1 1.6 2 0 0 2 2 2 0 Exocyst complex subunit Sec15-like Bacteriocin_IId PF09221.10 KPI85936.1 - 0.081 13.1 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Bacteriocin class IId cyclical uberolysin-like Ery_res_leader2 PF08057.11 KPI85936.1 - 0.097 13.1 0.0 0.3 11.7 0.0 1.9 1 0 0 1 1 1 0 Erythromycin resistance leader peptide Porin_3 PF01459.22 KPI85936.1 - 0.15 11.5 0.3 0.46 9.9 0.2 2.0 2 1 0 2 2 2 0 Eukaryotic porin AAA_33 PF13671.6 KPI85937.1 - 1.9e-13 50.8 0.0 2.7e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KPI85937.1 - 0.0062 15.8 0.0 0.0095 15.2 0.0 1.5 1 1 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 KPI85937.1 - 0.015 15.3 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KPI85937.1 - 0.024 14.9 0.8 0.24 11.6 0.8 2.1 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 KPI85937.1 - 0.03 13.9 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF508 PF04370.12 KPI85937.1 - 0.051 13.3 0.2 0.082 12.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) AAA_5 PF07728.14 KPI85937.1 - 0.15 12.0 0.0 0.39 10.7 0.0 1.6 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) bZIP_Maf PF03131.17 KPI85937.1 - 1 9.9 3.9 1.3 9.6 1.4 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor TPT PF03151.16 KPI85938.1 - 6.1e-08 32.4 18.1 1.5e-07 31.0 18.1 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KPI85938.1 - 0.0018 18.4 31.5 0.0029 17.8 14.3 2.2 2 0 0 2 2 2 2 EamA-like transporter family Phage_holin_2_4 PF16082.5 KPI85938.1 - 0.023 14.4 0.0 0.061 13.1 0.0 1.7 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Pho86 PF11124.8 KPI85938.1 - 0.046 13.2 0.1 0.046 13.2 0.1 2.1 2 1 1 3 3 3 0 Inorganic phosphate transporter Pho86 Cellulose_synt PF03552.14 KPI85938.1 - 0.49 8.8 2.7 0.83 8.1 2.7 1.3 1 0 0 1 1 1 0 Cellulose synthase RRM_1 PF00076.22 KPI85939.1 - 1.6e-28 98.3 0.0 3e-15 55.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI85939.1 - 1.1e-06 28.6 0.0 0.0015 18.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 KPI85939.1 - 2.2e-06 27.2 0.0 0.00025 20.6 0.0 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KPI85939.1 - 0.0016 18.5 0.5 0.014 15.4 0.0 2.7 3 2 0 3 3 3 1 Limkain b1 RRM_8 PF11835.8 KPI85939.1 - 0.0016 18.6 0.0 0.49 10.6 0.0 2.4 2 0 0 2 2 2 2 RRM-like domain PHM7_cyt PF14703.6 KPI85939.1 - 0.0047 17.2 0.2 1.2 9.3 0.0 2.9 2 1 1 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 KPI85939.1 - 0.014 15.4 0.0 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Lipase_3 PF01764.25 KPI85940.1 - 1.4e-12 47.7 0.0 2.5e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 KPI85940.1 - 0.0068 17.0 0.2 0.016 15.9 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF4803 PF16061.5 KPI85940.1 - 0.013 15.0 2.1 0.86 9.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4803) Hydrolase_4 PF12146.8 KPI85940.1 - 0.16 11.2 0.1 4.6 6.4 0.0 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Metallophos PF00149.28 KPI85941.1 - 1.1e-29 104.4 0.2 1.8e-29 103.7 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 KPI85941.1 - 3.3e-21 75.4 0.3 2.5e-20 72.6 0.1 2.3 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 KPI85941.1 - 1.6e-13 49.9 1.2 0.00028 20.6 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI85941.1 - 4.8e-11 41.9 2.8 0.0013 18.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85941.1 - 3.3e-06 26.9 0.4 0.18 12.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI85941.1 - 0.00016 21.3 0.4 0.4 10.4 0.0 2.8 2 0 0 2 2 2 2 TPR repeat TPR_7 PF13176.6 KPI85941.1 - 0.0012 18.7 0.0 0.24 11.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KPI85941.1 - 0.0015 18.7 0.2 0.0077 16.5 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KPI85941.1 - 0.0041 17.7 3.3 0.13 12.9 2.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI85941.1 - 0.013 16.0 2.8 0.075 13.6 0.8 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85941.1 - 0.015 15.5 2.7 0.64 10.3 0.1 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI85941.1 - 0.017 15.9 0.4 8.8 7.4 0.0 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI85941.1 - 0.062 13.4 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 KPI85941.1 - 0.17 12.6 0.6 8.4 7.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF21 PF01595.20 KPI85942.1 - 1.1e-37 129.5 0.2 1.1e-37 129.5 0.2 1.7 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain DUF21 PF01595.20 KPI85943.1 - 4.1e-29 101.5 0.3 8.5e-29 100.5 0.3 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KPI85943.1 - 6.3e-07 29.7 4.6 0.01 16.2 0.1 3.8 4 0 0 4 4 4 2 CBS domain cNMP_binding PF00027.29 KPI85943.1 - 0.071 13.2 0.0 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain DUF726 PF05277.12 KPI85945.1 - 1.7e-57 194.9 28.3 2.4e-56 191.2 0.0 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF726) DUF3089 PF11288.8 KPI85945.1 - 0.019 14.5 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) VirJ PF06057.11 KPI85945.1 - 0.02 14.8 0.1 0.62 9.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) Abhydrolase_6 PF12697.7 KPI85945.1 - 1.4 9.4 7.3 0.34 11.5 0.1 2.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Chloroplast_duf PF14476.6 KPI85945.1 - 1.7 7.6 3.7 3.4 6.6 3.7 1.5 1 0 0 1 1 1 0 Petal formation-expressed Tafi-CsgC PF10610.9 KPI85946.1 - 0.007 16.5 0.6 0.18 12.0 0.1 2.4 2 0 0 2 2 2 1 Thin aggregative fimbriae synthesis protein Glyco_hydro_31 PF01055.26 KPI85947.1 - 2.4e-142 475.2 4.4 3e-142 474.9 4.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KPI85947.1 - 1e-17 64.2 0.2 2.2e-16 59.9 0.0 2.9 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 KPI85947.1 - 5.7e-07 29.7 0.2 1.7e-06 28.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) 3Beta_HSD PF01073.19 KPI85948.1 - 7.2e-09 35.0 0.0 1e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KPI85948.1 - 6.3e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KPI85948.1 - 0.0001 21.9 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 KPI85948.1 - 0.00012 22.4 0.0 0.0003 21.2 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 KPI85948.1 - 0.0066 15.6 0.1 1.4 8.0 0.0 3.0 3 1 0 3 3 3 1 RmlD substrate binding domain NmrA PF05368.13 KPI85948.1 - 0.022 14.3 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family DapB_N PF01113.20 KPI85948.1 - 0.051 13.7 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 KPI85948.1 - 0.19 11.6 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 KR domain zf-C2HC_2 PF13913.6 KPI85949.1 - 2.6e-43 145.2 49.1 1.7e-10 40.5 1.5 7.8 8 0 0 8 8 8 6 zinc-finger of a C2HC-type DZR PF12773.7 KPI85949.1 - 9.2e-18 64.0 56.2 7.8e-13 48.2 11.3 8.6 6 3 2 8 8 8 4 Double zinc ribbon zf-ribbon_3 PF13248.6 KPI85949.1 - 1.7e-05 24.0 60.8 0.0011 18.2 4.3 9.4 10 0 0 10 10 10 5 zinc-ribbon domain zinc_ribbon_2 PF13240.6 KPI85949.1 - 0.00064 19.3 3.5 0.00064 19.3 3.5 9.0 8 1 0 8 8 8 4 zinc-ribbon domain Rad50_zn_hook PF04423.14 KPI85949.1 - 0.002 17.9 15.3 0.48 10.3 0.1 5.8 6 0 0 6 6 6 2 Rad50 zinc hook motif zinc_ribbon_15 PF17032.5 KPI85949.1 - 0.013 16.2 41.3 0.28 11.9 1.7 7.7 8 1 0 8 8 8 0 zinc-ribbon family c-SKI_SMAD_bind PF08782.10 KPI85949.1 - 0.13 12.5 10.0 4.9 7.4 0.0 5.8 5 1 1 6 6 6 0 c-SKI Smad4 binding domain Evr1_Alr PF04777.13 KPI85949.1 - 1.2 9.6 3.2 33 5.0 0.0 4.0 4 0 0 4 4 4 0 Erv1 / Alr family zf_UBZ PF18439.1 KPI85949.1 - 1.9 8.1 39.7 2.3 7.9 0.1 11.1 10 1 2 12 12 12 0 Ubiquitin-Binding Zinc Finger zf-CpG_bind_C PF12269.8 KPI85949.1 - 8.3 6.1 13.7 9.3 6.0 0.0 5.2 5 1 1 6 6 6 0 CpG binding protein zinc finger C terminal domain Lentiviral_Tat PF02998.14 KPI85950.1 - 3.1 7.9 8.9 0.39 10.8 3.6 1.9 2 0 0 2 2 2 0 Lentiviral Tat protein TPR_14 PF13428.6 KPI85951.1 - 7 7.8 9.8 1.8 9.6 0.1 4.9 4 1 0 4 4 4 0 Tetratricopeptide repeat MFS_1 PF07690.16 KPI85952.1 - 1.1e-26 93.7 45.1 1.9e-26 92.8 45.1 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KPI85952.1 - 1.3e-12 47.3 13.6 1.3e-12 47.3 13.6 2.7 1 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 KPI85952.1 - 1e-11 43.9 30.1 9.9e-05 20.8 4.5 4.0 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 KPI85952.1 - 0.052 12.8 30.0 0.11 11.7 30.0 1.6 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Transgly_assoc PF04226.13 KPI85952.1 - 0.96 9.8 12.8 0.13 12.5 2.8 3.5 2 0 0 2 2 2 0 Transglycosylase associated protein DUF3959 PF13105.6 KPI85952.1 - 2.5 7.5 4.0 0.59 9.6 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) RRM_1 PF00076.22 KPI85953.1 - 4.1e-05 23.3 0.0 7.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KPI85953.1 - 0.031 14.5 0.1 0.086 13.1 0.1 1.7 1 0 0 1 1 1 0 BRCA1-associated protein 2 MDD_C PF18376.1 KPI85954.1 - 8e-55 185.5 0.1 1.2e-54 184.9 0.1 1.3 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 KPI85954.1 - 2.2e-05 24.6 5.2 4.5e-05 23.6 5.2 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain Ribosomal_L6 PF00347.23 KPI85954.1 - 0.063 14.0 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L6 AKNA PF12443.8 KPI85955.1 - 0.0037 17.9 0.6 3.3 8.4 0.0 2.7 2 0 0 2 2 2 2 AT-hook-containing transcription factor PPR_2 PF13041.6 KPI85956.1 - 1.3e-43 146.9 12.1 4.4e-06 26.8 0.1 12.9 7 4 7 14 14 14 8 PPR repeat family PPR PF01535.20 KPI85956.1 - 2.9e-39 130.6 21.2 0.00083 19.4 0.0 16.5 17 0 0 17 17 17 10 PPR repeat PPR_3 PF13812.6 KPI85956.1 - 1.1e-19 70.2 1.9 0.07 13.2 0.0 9.6 7 2 3 10 10 10 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 KPI85956.1 - 3.1e-16 58.7 9.6 0.021 14.5 0.1 11.8 12 1 0 12 12 12 4 PPR repeat PPR_long PF17177.4 KPI85956.1 - 1.8e-10 40.5 0.5 0.012 15.0 0.2 4.8 3 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP SPOB_a PF14689.6 KPI85956.1 - 0.00011 21.8 0.5 14 5.5 0.0 5.3 4 1 1 5 5 5 1 Sensor_kinase_SpoOB-type, alpha-helical domain ATP13 PF12921.7 KPI85956.1 - 0.0012 18.7 0.0 7.1 6.5 0.0 4.8 3 2 1 4 4 4 1 Mitochondrial ATPase expression TPR_7 PF13176.6 KPI85956.1 - 0.0016 18.3 0.0 0.053 13.6 0.0 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.9 KPI85956.1 - 0.0092 15.7 0.3 0.08 12.6 0.0 2.8 3 1 1 4 4 4 1 26S proteasome subunit RPN7 TPR_14 PF13428.6 KPI85956.1 - 0.015 16.1 7.0 0.87 10.6 0.1 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI85956.1 - 0.066 13.4 3.6 0.34 11.1 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI85958.1 - 1.7e-23 81.4 7.3 1.8e-08 33.9 0.1 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI85958.1 - 1.1e-16 59.5 16.2 6.3e-08 32.2 0.1 4.9 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85958.1 - 5.4e-13 48.1 4.5 4.8e-05 23.3 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI85958.1 - 6e-13 48.3 8.2 2.5e-07 30.2 0.5 3.8 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 KPI85958.1 - 3.8e-10 39.4 2.6 0.0024 18.1 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI85958.1 - 4.3e-07 29.5 0.3 0.034 14.2 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat SGT1 PF07093.11 KPI85958.1 - 6.6e-07 28.2 1.2 9.4e-07 27.6 1.2 1.2 1 0 0 1 1 1 1 SGT1 protein TPR_14 PF13428.6 KPI85958.1 - 7.7e-07 29.4 2.5 0.027 15.3 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI85958.1 - 8.7e-07 29.5 9.4 0.0011 19.5 0.0 3.9 4 1 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI85958.1 - 1.7e-06 28.2 5.5 0.00047 20.4 0.4 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat STI1 PF17830.1 KPI85958.1 - 1.9e-06 27.7 10.0 0.00054 19.9 1.5 3.2 3 0 0 3 3 2 2 STI1 domain TPR_19 PF14559.6 KPI85958.1 - 5.4e-05 23.6 3.7 0.073 13.6 0.4 3.3 2 1 0 3 3 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 KPI85958.1 - 0.0011 18.8 8.8 1.4 8.9 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TOM20_plant PF06552.12 KPI85958.1 - 0.0059 16.4 3.9 0.061 13.1 0.3 3.7 1 1 2 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_6 PF13174.6 KPI85958.1 - 0.0081 16.7 5.4 0.67 10.7 0.1 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI85958.1 - 0.013 15.6 2.9 6.9 6.8 0.1 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KPI85958.1 - 0.022 14.9 1.8 0.36 11.0 0.0 2.9 3 1 1 4 4 2 0 Tetratricopeptide repeat Ins_allergen_rp PF06757.13 KPI85958.1 - 0.023 14.7 0.9 1.5 8.8 0.0 3.0 3 1 1 4 4 4 0 Insect allergen related repeat, nitrile-specifier detoxification MIT PF04212.18 KPI85958.1 - 0.056 13.5 8.3 0.98 9.5 0.5 4.1 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 KPI85958.1 - 0.12 12.7 4.5 1.6 9.0 0.8 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 KPI85958.1 - 0.41 10.7 3.0 2.6 8.2 0.1 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat XPC-binding PF09280.11 KPI85958.1 - 0.84 9.4 4.0 8 6.3 0.0 3.3 3 0 0 3 3 3 0 XPC-binding domain Smg4_UPF3 PF03467.15 KPI85958.1 - 3.1 7.8 8.2 0.56 10.2 2.3 2.6 3 0 0 3 3 3 0 Smg-4/UPF3 family SPA PF08616.10 KPI85959.1 - 4.5e-29 100.7 0.0 8.1e-29 99.9 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 KPI85959.1 - 1.4e-06 28.8 0.0 2.9e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 KPI85959.1 - 0.0091 14.7 0.0 0.15 10.7 0.0 2.2 1 1 1 2 2 2 1 Transport protein Avl9 DENN PF02141.21 KPI85959.1 - 0.01 15.8 0.0 0.034 14.1 0.0 2.0 1 0 0 1 1 1 0 DENN (AEX-3) domain GRAM PF02893.20 KPI85960.1 - 4.7e-14 52.2 0.3 1e-13 51.1 0.3 1.6 1 0 0 1 1 1 1 GRAM domain Myc_target_1 PF15179.6 KPI85960.1 - 0.032 14.1 0.7 0.074 12.9 0.0 1.9 2 0 0 2 2 2 0 Myc target protein 1 SH3_1 PF00018.28 KPI85963.1 - 8.8e-08 31.6 0.0 1.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KPI85963.1 - 8.3e-07 28.8 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KPI85963.1 - 7.5e-06 25.5 0.0 1.3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain CortBP2 PF09727.9 KPI85963.1 - 0.0037 17.2 0.5 0.0053 16.7 0.5 1.1 1 0 0 1 1 1 1 Cortactin-binding protein-2 OmpH PF03938.14 KPI85963.1 - 0.13 12.6 0.1 0.19 12.1 0.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPT PF03151.16 KPI85964.1 - 7.4e-12 45.2 20.8 8.9e-12 44.9 20.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KPI85964.1 - 4.7e-05 23.6 32.6 0.00013 22.2 14.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPR_12 PF13424.6 KPI85966.1 - 7.3e-06 26.2 1.6 0.0026 18.0 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KPI85966.1 - 0.012 15.0 0.4 0.056 12.8 0.2 1.9 2 0 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 KPI85966.1 - 0.12 12.3 2.5 1.4 8.8 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI85966.1 - 0.22 11.8 0.8 15 6.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ubiquitin PF00240.23 KPI85967.1 - 0.00069 19.3 0.0 0.00093 18.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family CLU_N PF15044.6 KPI85967.1 - 0.11 12.8 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial function, CLU-N-term rRNA_methylase PF06962.12 KPI85967.1 - 0.15 12.0 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative rRNA methylase Rep_fac_C PF08542.11 KPI85970.1 - 1.2e-13 51.3 0.0 2.4e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 KPI85970.1 - 6.5e-13 49.2 0.0 1.7e-12 47.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KPI85970.1 - 5e-10 39.4 0.0 4.6e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase III, delta subunit AAA_11 PF13086.6 KPI85970.1 - 1.2e-05 25.2 0.0 3e-05 24.0 0.0 1.6 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 KPI85970.1 - 1.2e-05 25.6 0.0 4.2e-05 23.8 0.0 1.9 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.12 KPI85970.1 - 2.1e-05 24.3 0.0 0.0001 22.1 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KPI85970.1 - 2.6e-05 24.2 0.0 4.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KPI85970.1 - 6.5e-05 23.4 0.6 0.00048 20.5 0.0 2.5 2 2 0 3 3 3 1 AAA ATPase domain DUF2075 PF09848.9 KPI85970.1 - 0.0018 17.6 0.0 0.0024 17.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KPI85970.1 - 0.0028 17.7 0.0 0.013 15.5 0.0 2.0 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KPI85970.1 - 0.015 15.1 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KPI85970.1 - 0.017 15.3 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KPI85970.1 - 0.021 14.2 0.0 0.07 12.5 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 KPI85970.1 - 0.022 13.9 0.0 0.075 12.2 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 KPI85970.1 - 0.022 14.7 0.0 0.054 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_assoc_2 PF16193.5 KPI85970.1 - 0.024 15.0 0.1 0.056 13.8 0.1 1.7 1 0 0 1 1 1 0 AAA C-terminal domain DEAD PF00270.29 KPI85970.1 - 0.032 14.0 0.0 0.73 9.6 0.0 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_19 PF13245.6 KPI85970.1 - 0.04 14.2 0.0 0.12 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KPI85970.1 - 0.075 12.7 0.0 0.17 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KPI85970.1 - 0.094 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KPI85970.1 - 0.094 12.2 0.0 0.37 10.3 0.0 1.9 3 0 0 3 3 3 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 KPI85970.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.6 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RRM_1 PF00076.22 KPI85973.1 - 2.3e-17 62.6 0.0 4.6e-16 58.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI85973.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF3138 PF11336.8 KPI85973.1 - 0.022 13.4 1.3 0.032 12.9 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RRM_occluded PF16842.5 KPI85973.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF1003 PF06210.11 KPI85973.1 - 0.082 13.0 1.3 0.14 12.3 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) FTHFS PF01268.19 KPI85974.1 - 3.1e-251 834.4 0.0 3.6e-251 834.2 0.0 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase Leu_Phe_trans PF03588.14 KPI85975.1 - 0.029 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase Reticulon PF02453.17 KPI85976.1 - 3.5e-27 95.3 4.4 5.1e-27 94.8 4.4 1.2 1 0 0 1 1 1 1 Reticulon PRT_C PF08372.10 KPI85976.1 - 0.095 12.5 2.0 0.82 9.4 0.1 2.2 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal DUF4175 PF13779.6 KPI85976.1 - 0.89 7.4 7.3 0.99 7.2 1.5 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4175) CoA_binding_3 PF13727.6 KPI85976.1 - 0.91 9.5 5.5 0.66 10.0 4.0 1.6 1 1 0 1 1 1 0 CoA-binding domain Cofilin_ADF PF00241.20 KPI85977.1 - 9.8e-11 41.5 0.0 1.4e-07 31.4 0.0 2.5 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF4726 PF15855.5 KPI85977.1 - 0.09 13.0 1.1 0.33 11.2 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4726) TSNAXIP1_N PF15739.5 KPI85978.1 - 1.7e-06 28.3 0.1 1.7e-06 28.3 0.1 4.1 3 2 1 4 4 4 1 Translin-associated factor X-interacting N-terminus TFIIA PF03153.13 KPI85978.1 - 0.02 14.9 22.4 0.1 12.6 11.2 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ARA70 PF12489.8 KPI85978.1 - 0.43 10.8 14.2 4.6 7.4 6.9 2.6 2 0 0 2 2 2 0 Nuclear coactivator Peptidase_S49_N PF08496.10 KPI85978.1 - 1.7 8.7 9.8 6.8 6.7 0.8 2.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal T5orf172 PF10544.9 KPI85978.1 - 2.9 8.5 5.1 1.7 9.2 0.0 3.1 4 0 0 4 4 4 0 T5orf172 domain PA26 PF04636.13 KPI85978.1 - 5.7 5.7 10.7 7.8 5.3 1.3 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF4821 PF16092.5 KPI85980.1 - 3.2e-14 53.2 0.0 3.1e-13 49.9 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4821) Thioredoxin PF00085.20 KPI85981.1 - 3.1e-50 168.4 0.2 1.5e-26 92.4 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 KPI85981.1 - 1.2e-20 74.0 0.1 6.6e-11 42.1 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family ERp29 PF07749.12 KPI85981.1 - 1.2e-17 64.6 0.2 2.9e-17 63.3 0.2 1.7 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 KPI85981.1 - 1.9e-12 47.6 1.5 2.9e-06 27.7 0.1 2.7 2 1 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 KPI85981.1 - 1.1e-08 35.0 0.1 0.0047 16.8 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 KPI85981.1 - 1.9e-07 31.3 1.1 0.0041 17.4 0.1 3.6 2 2 1 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.6 KPI85981.1 - 4.9e-07 29.8 0.9 0.0042 17.2 0.0 2.6 2 1 0 2 2 2 2 Thioredoxin-like TraF PF13728.6 KPI85981.1 - 1.2e-06 28.5 0.2 0.047 13.5 0.1 2.5 2 1 0 2 2 2 2 F plasmid transfer operon protein HyaE PF07449.11 KPI85981.1 - 0.00018 21.5 0.0 0.038 13.9 0.0 2.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 KPI85981.1 - 0.0031 17.2 0.6 1.1 8.9 0.1 3.6 2 2 1 3 3 3 1 Thioredoxin Redoxin PF08534.10 KPI85981.1 - 0.0036 17.0 0.2 0.47 10.2 0.1 2.6 2 0 0 2 2 2 1 Redoxin DUF3235 PF11574.8 KPI85981.1 - 0.0086 16.9 2.3 2.2 9.2 1.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3235) Thioredoxin_9 PF14595.6 KPI85981.1 - 0.16 11.7 0.2 0.67 9.7 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin Glutaredoxin PF00462.24 KPI85981.1 - 1.6 9.0 4.9 77 3.6 0.0 3.6 2 1 0 2 2 2 0 Glutaredoxin Thioredoxin PF00085.20 KPI85982.1 - 6.9e-18 64.5 0.0 9.5e-18 64.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KPI85982.1 - 5.3e-05 23.6 0.0 0.00011 22.6 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KPI85982.1 - 7.2e-05 22.3 0.1 0.00012 21.5 0.0 1.4 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KPI85982.1 - 9.9e-05 22.6 0.1 0.074 13.4 0.1 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_7 PF13899.6 KPI85982.1 - 0.00012 22.2 0.0 0.00026 21.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KPI85982.1 - 0.01 15.8 0.1 0.045 13.7 0.1 1.9 1 1 1 2 2 2 0 AhpC/TSA family TraF PF13728.6 KPI85982.1 - 0.01 15.7 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein BAGE PF08180.11 KPI85982.1 - 0.11 12.6 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 B melanoma antigen family DUF2012 PF09430.10 KPI85983.1 - 9.4e-30 103.3 0.1 1.3e-29 102.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 KPI85983.1 - 0.00072 19.8 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain TatD_DNase PF01026.21 KPI85983.1 - 0.073 12.4 0.0 0.09 12.1 0.0 1.1 1 0 0 1 1 1 0 TatD related DNase SpaA PF17802.1 KPI85983.1 - 0.11 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Prealbumin-like fold domain SNARE PF05739.19 KPI85984.1 - 6.3e-09 35.7 1.2 2e-08 34.1 1.2 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin-6_N PF09177.11 KPI85984.1 - 0.00035 21.1 2.6 0.0028 18.2 0.4 2.4 2 1 0 2 2 2 1 Syntaxin 6, N-terminal DHR10 PF18595.1 KPI85984.1 - 0.063 13.3 12.8 0.21 11.7 0.1 2.8 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain Efg1 PF10153.9 KPI85984.1 - 0.11 12.8 2.9 0.24 11.8 2.8 1.6 1 1 0 1 1 1 0 rRNA-processing protein Efg1 Snapin_Pallidin PF14712.6 KPI85984.1 - 0.17 12.3 6.9 3.4 8.1 1.1 2.9 2 1 0 2 2 2 0 Snapin/Pallidin Laminin_II PF06009.12 KPI85984.1 - 0.18 11.8 5.3 0.43 10.6 0.8 2.5 2 1 0 2 2 2 0 Laminin Domain II PSI_PsaF PF02507.15 KPI85984.1 - 0.29 10.9 1.7 20 5.0 0.0 2.3 1 1 1 2 2 2 0 Photosystem I reaction centre subunit III DUF2951 PF11166.8 KPI85984.1 - 0.88 9.8 4.0 0.8 10.0 0.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) Fib_alpha PF08702.10 KPI85984.1 - 0.93 9.7 6.3 1.8 8.8 1.9 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family T3SSipB PF16535.5 KPI85984.1 - 1.2 9.6 11.8 1 9.8 0.1 2.4 1 1 1 2 2 2 0 Type III cell invasion protein SipB TBCA PF02970.16 KPI85984.1 - 2.8 8.3 8.9 0.15 12.4 0.5 2.8 1 1 2 3 3 3 0 Tubulin binding cofactor A Exonuc_VII_L PF02601.15 KPI85984.1 - 5.6 6.4 9.1 9.8 5.6 9.1 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit ArAE_2_N PF10337.9 KPI85984.1 - 6.5 5.7 6.3 2.7 6.9 1.5 2.0 1 1 1 2 2 2 0 Putative ER transporter, 6TM, N-terminal Pentapeptide_4 PF13599.6 KPI85985.1 - 1.2e-08 35.0 7.0 3.5e-05 23.9 0.9 3.2 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 KPI85985.1 - 1e-06 28.8 8.7 0.0087 16.2 0.0 3.8 4 0 0 4 4 4 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 KPI85985.1 - 1.1e-05 25.0 0.5 0.00087 18.9 0.0 3.3 2 1 1 3 3 3 2 Pentapeptide repeats (8 copies) DAGK_cat PF00781.24 KPI85986.1 - 2.1e-16 59.7 0.0 2.4e-14 53.0 0.0 2.9 2 0 0 2 2 2 2 Diacylglycerol kinase catalytic domain KN_motif PF12075.8 KPI85986.1 - 0.088 12.6 0.0 0.66 9.8 0.0 2.4 2 0 0 2 2 2 0 KN motif Trypsin_2 PF13365.6 KPI85987.1 - 0.0053 17.7 0.3 0.034 15.0 0.1 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain RCC1 PF00415.18 KPI85989.1 - 1.7e-68 227.0 36.4 1.6e-13 51.1 0.5 12.1 11 2 0 11 11 11 10 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI85989.1 - 3.4e-34 115.9 75.1 4.5e-07 29.5 0.0 11.7 13 0 0 13 13 13 8 Regulator of chromosome condensation (RCC1) repeat GAD-like PF08887.11 KPI85989.1 - 0.35 10.7 1.3 33 4.3 0.1 3.9 4 0 0 4 4 4 0 GAD-like domain SUIM_assoc PF16619.5 KPI85989.1 - 9.1 6.4 9.8 19 5.4 9.8 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RCC1 PF00415.18 KPI85990.1 - 1.1e-57 192.5 35.8 8.6e-10 39.1 0.0 13.1 12 1 0 12 12 12 10 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI85990.1 - 9.6e-37 124.1 60.2 1.5e-06 27.9 0.1 13.1 13 0 0 13 13 13 10 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 KPI85990.1 - 0.0097 15.6 0.3 39 3.9 0.0 4.5 4 1 1 5 5 5 0 TUP1-like enhancer of split DUF1459 PF07312.11 KPI85990.1 - 0.077 13.2 0.0 1.6 9.0 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1459) DUF4213 PF13938.6 KPI85990.1 - 0.53 10.6 3.8 3.4 8.0 0.2 3.7 4 0 0 4 4 4 0 Putative heavy-metal chelation Ribosomal_L4 PF00573.22 KPI85990.1 - 1.4 8.5 4.5 3 7.5 4.5 1.4 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family RRM_1 PF00076.22 KPI85991.1 - 1.2e-09 37.8 0.0 1.8e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUA_3 PF17785.1 KPI85991.1 - 0.095 12.5 0.0 3.1 7.7 0.0 2.4 2 0 0 2 2 2 0 PUA-like domain GDYXXLXY PF14345.6 KPI85992.1 - 0.11 12.3 0.5 0.34 10.7 0.5 1.9 1 0 0 1 1 1 0 GDYXXLXY protein Cullin PF00888.22 KPI85993.1 - 8.7e-37 127.0 0.1 1.4e-36 126.3 0.1 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KPI85993.1 - 2.9e-09 36.8 1.1 5.5e-09 35.9 0.2 2.0 2 0 0 2 2 2 1 Cullin protein neddylation domain TrmB PF01978.19 KPI85993.1 - 0.039 13.8 1.2 3.9 7.4 0.0 3.1 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB Symplekin_C PF12295.8 KPI85993.1 - 1 9.4 3.4 4.8 7.2 0.0 3.4 4 0 0 4 4 4 0 Symplekin tight junction protein C terminal RRM_1 PF00076.22 KPI85994.1 - 2e-05 24.3 0.0 0.00032 20.5 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GSHPx PF00255.19 KPI85996.1 - 5.5e-26 90.3 0.1 8.1e-26 89.7 0.1 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KPI85996.1 - 0.027 14.4 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Pkinase PF00069.25 KPI85997.1 - 2.4e-59 200.9 0.0 3.6e-59 200.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI85997.1 - 4.5e-40 137.6 0.0 8.3e-39 133.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI85997.1 - 0.0057 16.0 0.0 0.028 13.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI85997.1 - 0.018 13.8 0.1 0.066 12.0 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase ABC1 PF03109.16 KPI85997.1 - 0.088 13.0 0.1 0.28 11.4 0.0 1.8 2 0 0 2 2 2 0 ABC1 family Haspin_kinase PF12330.8 KPI85997.1 - 0.15 10.9 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Nop14 PF04147.12 KPI85997.1 - 0.25 9.5 22.6 0.39 8.9 22.6 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KPI85997.1 - 2 6.6 17.4 3.3 5.9 17.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PhzC-PhzF PF02567.16 KPI85998.1 - 1e-36 126.9 1.0 7.4e-26 91.2 0.0 4.2 3 1 0 3 3 3 3 Phenazine biosynthesis-like protein Sigma70_r4 PF04545.16 KPI85998.1 - 0.0061 16.1 0.6 0.054 13.0 0.0 2.5 3 0 0 3 3 3 1 Sigma-70, region 4 PIEZO PF15917.5 KPI85999.1 - 0.5 9.8 2.9 3.5 7.0 3.3 2.0 2 0 0 2 2 2 0 Piezo DnaJ PF00226.31 KPI86000.1 - 6.5e-10 39.0 0.0 1.3e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1515 PF07439.11 KPI86002.1 - 0.22 11.6 1.0 0.63 10.1 1.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) N6-adenineMlase PF10237.9 KPI86004.1 - 5.3e-33 114.1 0.2 8e-33 113.5 0.2 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase MTS PF05175.14 KPI86004.1 - 0.014 15.0 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 KPI86004.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF4407 PF14362.6 KPI86004.1 - 0.19 11.0 5.0 0.34 10.2 5.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlxA PF14282.6 KPI86004.1 - 0.51 10.4 6.0 1.5 8.9 6.1 1.7 1 1 0 1 1 1 0 FlxA-like protein CCDC-167 PF15188.6 KPI86004.1 - 2.7 8.4 13.2 7.5 7.0 0.3 3.8 4 0 0 4 4 4 0 Coiled-coil domain-containing protein 167 ABC_tran_CTD PF16326.5 KPI86004.1 - 9.3 6.6 13.4 59 4.0 8.1 3.6 2 1 1 3 3 3 0 ABC transporter C-terminal domain NIBRIN_BRCT_II PF16508.5 KPI86005.1 - 0.037 14.4 0.0 0.086 13.2 0.0 1.6 1 0 0 1 1 1 0 Second BRCT domain on Nijmegen syndrome breakage protein Yop-YscD_cpl PF16697.5 KPI86005.1 - 0.15 12.4 0.2 0.64 10.4 0.0 2.1 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain zf-RING_2 PF13639.6 KPI86007.1 - 2.6e-06 27.6 4.7 2.6e-06 27.6 4.7 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 KPI86007.1 - 0.00022 21.0 4.0 0.0007 19.4 4.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI86007.1 - 0.00034 20.6 2.9 0.00034 20.6 2.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 KPI86007.1 - 0.0011 18.7 4.5 0.0027 17.4 4.5 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KPI86007.1 - 0.0021 17.9 2.7 0.0021 17.9 2.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KPI86007.1 - 0.01 16.1 2.8 0.01 16.1 2.8 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-Nse PF11789.8 KPI86007.1 - 0.021 14.7 2.5 0.045 13.6 2.5 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 KPI86007.1 - 0.35 10.9 2.7 1.3 9.1 2.7 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 KPI86007.1 - 3.2 7.9 6.8 11 6.3 6.3 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 KPI86007.1 - 5.8 7.0 16.4 0.016 15.2 6.2 2.1 2 0 0 2 2 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KPI86007.1 - 7 6.9 11.9 0.14 12.3 3.9 2.4 2 1 0 2 2 1 0 zinc finger of C3HC4-type, RING EIF_2_alpha PF07541.12 KPI86009.1 - 3e-16 59.5 0.0 1.5e-15 57.3 0.0 2.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 KPI86009.1 - 3e-12 46.7 0.8 5.3e-12 45.9 0.8 1.4 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.9 KPI86009.1 - 0.015 15.9 0.1 0.041 14.5 0.1 1.7 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 TRAM PF01938.20 KPI86009.1 - 0.11 12.5 0.1 0.51 10.4 0.0 2.1 2 0 0 2 2 2 0 TRAM domain Ntox35 PF15534.6 KPI86009.1 - 0.15 12.5 0.0 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial toxin 35 MORN PF02493.20 KPI86010.1 - 1.6e-20 71.7 34.3 1.7e-06 27.6 2.4 7.1 7 1 0 7 7 7 5 MORN repeat IL4_i_Ig PF18258.1 KPI86011.1 - 0.078 13.2 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Interleukin-4 inducing immunoglobulin-binding domain Cu-oxidase_2 PF07731.14 KPI86012.1 - 9.2e-17 61.1 5.3 1.3e-16 60.6 0.4 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 KPI86012.1 - 1.9e-08 34.3 6.0 2.1e-05 24.5 1.3 3.6 2 1 0 2 2 2 2 Multicopper oxidase Mfa_like_2 PF15415.6 KPI86012.1 - 0.089 11.7 0.1 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Fimbrillin-like GBP_PSP PF02425.15 KPI86013.1 - 0.099 12.3 0.4 0.28 10.9 0.4 1.8 1 0 0 1 1 1 0 Paralytic/GBP/PSP peptide Peptidase_S49_N PF08496.10 KPI86014.1 - 10 6.2 20.9 7.2 6.7 5.4 2.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Amidohydro_3 PF07969.11 KPI86016.1 - 3.4e-64 218.0 7.0 6.4e-64 217.1 7.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 KPI86016.1 - 9.4e-12 44.9 0.0 1.8e-06 27.5 0.0 3.3 3 1 0 3 3 3 3 Amidohydrolase family Got1 PF04178.12 KPI86017.1 - 2.4e-29 102.0 19.3 3.5e-29 101.5 19.3 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family Sdh_cyt PF01127.22 KPI86017.1 - 0.11 12.5 8.8 0.07 13.2 6.0 2.0 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PEP-CTERM PF07589.11 KPI86017.1 - 8.3 6.7 7.7 36 4.7 4.0 2.7 2 0 0 2 2 2 0 PEP-CTERM motif Pyrophosphatase PF00719.19 KPI86018.1 - 5.5e-43 146.5 0.0 6.8e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Brix PF04427.18 KPI86019.1 - 1.1e-34 120.3 0.0 1.7e-34 119.6 0.0 1.3 1 0 0 1 1 1 1 Brix domain Herpes_UL31 PF02718.14 KPI86019.1 - 0.12 11.3 0.1 0.26 10.2 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus UL31-like protein Atg14 PF10186.9 KPI86019.1 - 1 8.4 8.1 1.5 7.8 8.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NIF PF03031.18 KPI86020.1 - 2.6e-25 89.0 0.0 3.2e-18 66.0 0.0 2.6 3 0 0 3 3 3 2 NLI interacting factor-like phosphatase LRR_4 PF12799.7 KPI86022.1 - 3.1e-09 36.9 10.9 0.0037 17.7 0.1 4.7 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI86022.1 - 2e-06 27.5 15.2 0.0038 17.0 0.4 4.2 3 1 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 KPI86022.1 - 0.0032 17.4 0.9 22 5.4 0.0 4.2 3 0 0 3 3 3 1 Leucine Rich repeat LRR_9 PF14580.6 KPI86022.1 - 0.013 15.0 1.1 0.024 14.1 1.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeat zf-C6H2 PF15801.5 KPI86025.1 - 4e-10 39.8 6.0 1e-09 38.5 6.0 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 KPI86025.1 - 0.00059 19.9 4.7 0.0018 18.3 4.7 1.9 1 0 0 1 1 1 1 MYND finger SUI1 PF01253.22 KPI86027.1 - 1.6e-20 73.4 0.7 2.2e-20 73.0 0.7 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 YL1 PF05764.13 KPI86028.1 - 9e-10 39.1 26.8 1.4e-09 38.4 26.8 1.3 1 0 0 1 1 1 1 YL1 nuclear protein SR-25 PF10500.9 KPI86028.1 - 0.00029 20.5 15.9 0.00045 19.9 15.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Draxin PF15550.6 KPI86028.1 - 0.018 14.9 8.5 0.029 14.2 8.5 1.3 1 0 0 1 1 1 0 Draxin DUF4603 PF15376.6 KPI86028.1 - 0.083 10.3 10.6 0.096 10.1 10.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Dicty_REP PF05086.12 KPI86028.1 - 0.12 10.3 6.7 0.15 10.0 6.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SRP-alpha_N PF04086.13 KPI86028.1 - 0.14 12.0 11.5 0.18 11.7 11.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 KPI86028.1 - 0.26 10.0 9.0 0.3 9.8 9.0 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 KPI86028.1 - 0.47 9.2 6.7 0.56 9.0 6.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S30 PF01577.16 KPI86028.1 - 0.48 10.0 10.6 0.73 9.4 10.6 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease Lin-8 PF03353.15 KPI86028.1 - 0.58 9.7 9.5 0.72 9.4 9.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF755 PF05501.11 KPI86028.1 - 0.7 10.2 18.1 1.7 9.0 18.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF2992 PF11208.8 KPI86028.1 - 1.7 8.9 15.8 4.2 7.6 15.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) GREB1 PF15782.5 KPI86028.1 - 1.8 5.5 6.2 2 5.4 6.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer WDCP PF15390.6 KPI86028.1 - 3 6.1 9.8 3.8 5.8 9.8 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family ALMT PF11744.8 KPI86028.1 - 4 6.2 6.4 5 5.8 6.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Med19 PF10278.9 KPI86028.1 - 9.1 6.2 10.1 14 5.5 10.1 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Bax1-I PF01027.20 KPI86029.1 - 3.1e-41 141.5 18.8 4.1e-41 141.1 18.8 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 KPI86029.1 - 2e-06 27.6 10.6 3.2e-06 26.9 10.5 1.4 1 1 0 1 1 1 1 Bax inhibitor 1 like SURF6 PF04935.12 KPI86030.1 - 2.8e-15 56.6 15.1 2.8e-15 56.6 15.1 1.7 1 1 1 2 2 2 1 Surfeit locus protein 6 Adaptin_binding PF10199.9 KPI86031.1 - 2e-05 25.2 0.0 0.0095 16.5 0.0 3.8 3 1 0 3 3 3 1 Alpha and gamma adaptin binding protein p34 TRAF_BIRC3_bd PF16673.5 KPI86032.1 - 0.13 12.1 10.3 0.025 14.4 2.2 3.5 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain RNA_pol PF00940.19 KPI86033.1 - 5.5e-133 443.8 0.0 7.9e-133 443.3 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase DotU PF09850.9 KPI86033.1 - 0.1 12.3 0.1 0.35 10.6 0.1 1.9 1 0 0 1 1 1 0 Type VI secretion system protein DotU fn3 PF00041.21 KPI86034.1 - 1.8e-14 53.9 10.6 0.0024 18.2 0.0 10.3 10 1 0 10 10 10 4 Fibronectin type III domain EF-hand_1 PF00036.32 KPI86035.1 - 0.009 15.5 0.0 0.7 9.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KPI86035.1 - 0.13 12.2 0.0 2.5 8.2 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain APG6_N PF17675.1 KPI86036.1 - 0.0044 17.5 13.6 0.0044 17.5 13.6 6.7 4 2 2 6 6 6 3 Apg6 coiled-coil region Csm1_N PF18504.1 KPI86036.1 - 0.012 15.9 0.3 0.012 15.9 0.3 10.2 10 2 2 12 12 12 0 Csm1 N-terminal domain Spc7 PF08317.11 KPI86036.1 - 0.073 11.9 73.4 0.042 12.7 9.5 5.2 4 1 1 5 5 5 0 Spc7 kinetochore protein Img2 PF05046.14 KPI86036.1 - 0.19 12.0 6.0 56 4.1 0.7 4.0 3 1 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) ATG16 PF08614.11 KPI86036.1 - 0.52 10.5 93.7 0.15 12.3 4.2 7.0 4 1 2 6 6 6 0 Autophagy protein 16 (ATG16) Ashwin PF15323.6 KPI86038.1 - 0.7 9.9 2.7 2.3 8.2 2.7 1.9 1 0 0 1 1 1 0 Developmental protein Fcf2 PF08698.11 KPI86040.1 - 0.054 13.9 3.2 0.42 11.0 0.7 2.4 2 0 0 2 2 2 0 Fcf2 pre-rRNA processing zf-C6H2 PF15801.5 KPI86040.1 - 0.067 13.5 0.3 0.17 12.2 0.3 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding SPESP1 PF15754.5 KPI86040.1 - 0.12 11.5 4.3 0.14 11.3 0.2 2.0 1 1 1 2 2 2 0 Sperm equatorial segment protein 1 PPP4R2 PF09184.11 KPI86040.1 - 9.9 5.7 9.4 12 5.4 9.4 1.2 1 0 0 1 1 1 0 PPP4R2 FH2 PF02181.23 KPI86041.1 - 6.5e-49 167.0 0.0 1e-48 166.4 0.0 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain PTEN_C2 PF10409.9 KPI86041.1 - 0.0038 17.0 0.1 0.012 15.4 0.1 1.8 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein Porph_ging PF09697.10 KPI86041.1 - 0.13 12.8 0.0 0.42 11.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (Porph_ging) HA2 PF04408.23 KPI86042.1 - 3e-12 46.8 0.0 3e-12 46.8 0.0 2.3 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KPI86042.1 - 2.7e-11 43.6 0.0 6.4e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KPI86042.1 - 8.2e-09 35.8 0.0 2.6e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI86042.1 - 7e-07 29.2 0.0 1.5e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI86042.1 - 0.00015 22.0 0.4 0.00094 19.5 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI86042.1 - 0.00075 19.3 0.1 0.00075 19.3 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KPI86042.1 - 0.0019 18.5 0.1 0.0067 16.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 KPI86042.1 - 0.02 14.5 0.4 0.33 10.5 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 KPI86042.1 - 0.02 15.4 3.4 0.36 11.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Flavi_DEAD PF07652.14 KPI86042.1 - 0.14 12.1 0.3 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 Flavivirus DEAD domain DnaJ PF00226.31 KPI86043.1 - 7.5e-11 42.0 0.0 1.9e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain MIF4G_like_2 PF09090.11 KPI86043.1 - 0.094 12.2 5.6 0.13 11.7 5.6 1.1 1 0 0 1 1 1 0 MIF4G like DUF4407 PF14362.6 KPI86043.1 - 0.14 11.5 9.7 0.21 10.9 9.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) VSG_B PF13206.6 KPI86043.1 - 0.23 10.7 8.7 0.28 10.4 8.7 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain PVL_ORF50 PF07768.11 KPI86043.1 - 0.84 10.0 0.0 0.84 10.0 0.0 2.2 1 1 1 2 2 2 0 PVL ORF-50-like family Hid1 PF12722.7 KPI86043.1 - 1.1 7.3 3.6 1.3 7.1 3.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3039 PF11238.8 KPI86044.1 - 0.17 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) Lipid_DES PF08557.10 KPI86044.1 - 0.34 10.4 1.6 0.47 10.0 0.3 1.9 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) ATG16 PF08614.11 KPI86045.1 - 0.0037 17.5 27.9 0.0037 17.5 27.9 9.2 1 1 7 8 8 8 2 Autophagy protein 16 (ATG16) eIF3g PF12353.8 KPI86046.1 - 0.039 14.3 0.3 0.039 14.3 0.3 2.7 3 1 1 4 4 4 0 Eukaryotic translation initiation factor 3 subunit G ThiF PF00899.21 KPI86047.1 - 3.5e-07 29.8 0.0 8.7e-06 25.3 0.0 2.1 2 0 0 2 2 2 2 ThiF family TRAPPC-Trs85 PF12739.7 KPI86047.1 - 0.12 11.3 0.6 0.2 10.6 0.6 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit LIM PF00412.22 KPI86048.1 - 6.8e-06 26.2 1.8 1.4e-05 25.2 1.8 1.6 1 0 0 1 1 1 1 LIM domain zf-C4_ClpX PF06689.13 KPI86048.1 - 0.023 14.6 0.1 0.056 13.3 0.0 1.7 2 0 0 2 2 2 0 ClpX C4-type zinc finger WD40 PF00400.32 KPI86049.1 - 1.6e-05 25.5 0.5 15 6.7 0.0 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI86049.1 - 0.0015 18.8 0.2 2 8.7 0.0 4.2 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain SRPRB PF09439.10 KPI86050.1 - 6.6e-17 61.5 0.0 1.2e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KPI86050.1 - 1.5e-05 24.7 1.0 0.00027 20.6 0.2 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI86050.1 - 0.00015 21.8 0.0 0.0003 20.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 KPI86050.1 - 0.005 16.3 0.0 0.012 15.1 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF463 PF04317.12 KPI86050.1 - 0.01 14.8 0.0 0.42 9.5 0.0 2.2 2 0 0 2 2 2 0 YcjX-like family, DUF463 RsgA_GTPase PF03193.16 KPI86050.1 - 0.089 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase 6PF2K PF01591.18 KPI86050.1 - 0.18 11.1 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Peptidase_M16_C PF05193.21 KPI86051.1 - 4e-21 75.8 0.0 6.4e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KPI86051.1 - 1.4e-05 25.1 0.0 2.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) HTH_24 PF13412.6 KPI86051.1 - 0.3 10.7 1.3 0.99 9.0 0.1 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding 3HCDH_N PF02737.18 KPI86052.1 - 1.8e-33 116.0 0.0 3.2e-33 115.1 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 KPI86052.1 - 1.4e-32 113.0 0.0 3e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 KPI86052.1 - 1.5e-17 64.0 0.1 7.8e-08 32.8 0.0 3.5 2 1 1 3 3 3 3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 KPI86052.1 - 1.9e-14 53.9 0.0 4.6e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pkinase PF00069.25 KPI86055.1 - 1.3e-20 73.9 0.0 9.2e-16 58.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86055.1 - 1.7e-09 37.4 0.0 0.00023 20.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI86055.1 - 5.9e-07 28.6 0.0 8.6e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI86055.1 - 0.0021 18.0 0.1 0.0042 17.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KPI86055.1 - 0.0029 17.2 0.1 0.0059 16.2 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KPI86055.1 - 0.0039 16.6 0.4 0.0072 15.7 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KPI86055.1 - 0.037 13.3 0.1 0.15 11.3 0.1 1.8 1 1 0 1 1 1 0 Kinase-like Lipoprotein_21 PF14041.6 KPI86055.1 - 0.09 12.9 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 LppP/LprE lipoprotein Pkinase PF00069.25 KPI86057.1 - 1.2e-38 133.0 0.0 1.7e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86057.1 - 1.4e-17 63.8 0.0 2.2e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI86057.1 - 0.59 8.8 0.0 0.59 8.8 0.0 2.5 3 0 0 3 3 3 0 Fungal protein kinase adh_short_C2 PF13561.6 KPI86058.1 - 1.1e-33 116.8 0.9 1.1e-31 110.2 0.9 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KPI86058.1 - 7.2e-27 94.1 0.0 9.3e-25 87.2 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 KPI86058.1 - 0.026 14.0 0.4 0.06 12.8 0.4 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 KPI86058.1 - 0.053 14.1 0.4 0.32 11.6 0.2 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NADPH_Ox PF08414.10 KPI86058.1 - 0.17 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Respiratory burst NADPH oxidase zf-C3HC4 PF00097.25 KPI86059.1 - 2e-06 27.6 8.2 3.3e-06 26.9 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI86059.1 - 1.7e-05 24.8 7.3 3.5e-05 23.7 7.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KPI86059.1 - 0.0012 18.8 8.3 0.0023 17.8 8.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KPI86059.1 - 0.0042 16.9 9.1 0.0074 16.1 9.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI86059.1 - 0.013 15.7 8.7 0.023 14.8 8.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KPI86059.1 - 0.04 13.8 6.2 0.42 10.5 6.2 2.3 1 1 0 1 1 1 0 zf-RING of BARD1-type protein SUIM_assoc PF16619.5 KPI86059.1 - 0.18 11.9 7.9 0.019 15.0 1.9 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-RING_2 PF13639.6 KPI86059.1 - 0.18 12.2 9.2 0.34 11.3 9.2 1.4 1 0 0 1 1 1 0 Ring finger domain TF_Zn_Ribbon PF08271.12 KPI86059.1 - 0.25 10.9 6.3 0.59 9.7 6.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Baculo_IE-1 PF05290.11 KPI86059.1 - 0.26 11.2 2.8 0.5 10.3 2.8 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_3 PF13920.6 KPI86059.1 - 0.86 9.5 8.9 1.7 8.5 8.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) YajC PF02699.15 KPI86059.1 - 1 9.3 2.2 2.3 8.2 2.2 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit Prok-RING_4 PF14447.6 KPI86059.1 - 1.4 8.8 8.1 4.1 7.3 8.1 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Hus1 PF04005.12 KPI86060.1 - 5.1e-70 235.9 0.0 5.9e-70 235.7 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein tRNA-synt_1b PF00579.25 KPI86061.1 - 2.4e-20 73.1 0.0 4e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) AAA_16 PF13191.6 KPI86062.1 - 2.2e-05 24.9 0.0 6.5e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain tRNA_lig_kinase PF08303.11 KPI86062.1 - 0.00094 19.3 0.0 0.005 17.0 0.0 2.0 1 1 0 1 1 1 1 tRNA ligase kinase domain AAA_5 PF07728.14 KPI86062.1 - 0.0067 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 KPI86062.1 - 0.0085 16.6 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 KPI86062.1 - 0.017 15.4 0.0 0.049 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KPI86062.1 - 0.018 15.6 0.2 0.1 13.1 0.0 2.3 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 KPI86062.1 - 0.031 14.6 0.0 0.07 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase RuvB_N PF05496.12 KPI86062.1 - 0.032 14.0 0.0 0.077 12.7 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KPI86062.1 - 0.036 14.2 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KPI86062.1 - 0.043 13.2 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 KPI86062.1 - 0.089 13.2 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KPI86062.1 - 0.097 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Imm51 PF15595.6 KPI86062.1 - 0.19 11.7 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 51 AAA_PrkA PF08298.11 KPI86062.1 - 0.26 10.1 0.0 0.44 9.4 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain AAA_15 PF13175.6 KPI86062.1 - 0.29 10.8 0.0 0.43 10.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain MIF4G_like_2 PF09090.11 KPI86063.1 - 0.094 12.2 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 MIF4G like V-ATPase_G PF03179.15 KPI86065.1 - 1.9e-18 66.9 14.7 2.1e-18 66.8 14.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF4521 PF15021.6 KPI86065.1 - 0.012 15.6 2.9 0.014 15.3 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4521) Cupin_8 PF13621.6 KPI86065.1 - 0.44 10.2 2.3 0.48 10.1 2.3 1.1 1 0 0 1 1 1 0 Cupin-like domain ArAE_2_N PF10337.9 KPI86065.1 - 1.5 7.8 5.0 1.7 7.6 5.0 1.0 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal ADH_N PF08240.12 KPI86070.1 - 1.8e-26 92.2 7.8 1.8e-26 92.2 7.8 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI86070.1 - 7.5e-25 87.4 0.0 1.5e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KPI86070.1 - 7.3e-10 38.7 0.2 1.1e-09 38.1 0.2 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 KPI86070.1 - 3.9e-08 32.8 0.3 6.5e-08 32.1 0.3 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 KPI86070.1 - 3.3e-06 28.2 0.0 5.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KPI86070.1 - 3.5e-06 26.5 0.2 5.6e-06 25.8 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 KPI86070.1 - 0.00012 22.3 0.7 0.00025 21.3 0.7 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KPI86070.1 - 0.00061 19.9 0.5 0.0013 18.8 0.1 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 KPI86070.1 - 0.0014 18.5 0.8 0.0023 17.9 0.8 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 KPI86070.1 - 0.0057 16.1 0.4 0.027 13.9 0.9 1.9 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 KPI86070.1 - 0.011 15.6 0.3 0.018 14.9 0.3 1.3 1 0 0 1 1 1 0 NAD(P)H-binding ApbA PF02558.16 KPI86070.1 - 0.019 14.6 0.3 0.019 14.6 0.3 1.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 KPI86070.1 - 0.021 15.1 0.5 0.036 14.3 0.5 1.3 1 0 0 1 1 1 0 TrkA-N domain adh_short_C2 PF13561.6 KPI86070.1 - 0.061 12.9 0.3 0.1 12.1 0.3 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase ELFV_dehydrog PF00208.21 KPI86070.1 - 0.067 12.9 0.4 0.17 11.5 0.1 1.7 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pyr_redox PF00070.27 KPI86070.1 - 0.13 12.8 1.4 0.34 11.5 1.4 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 KPI86070.1 - 3.2 7.0 5.2 0.5 9.7 0.9 1.8 2 0 0 2 2 2 0 ThiF family ABC_tran PF00005.27 KPI86072.1 - 5.4e-29 101.4 0.0 9.8e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 KPI86072.1 - 3.8e-23 82.0 19.7 3.8e-23 82.0 19.7 2.4 2 0 0 2 2 2 1 ABC-2 type transporter AAA_16 PF13191.6 KPI86072.1 - 3.5e-05 24.3 0.1 0.00011 22.6 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KPI86072.1 - 0.00047 20.1 0.2 0.38 10.5 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KPI86072.1 - 0.0011 18.2 17.3 0.0011 18.2 17.3 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 KPI86072.1 - 0.0017 18.3 0.1 0.0041 17.1 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KPI86072.1 - 0.0022 17.7 0.0 0.005 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 KPI86072.1 - 0.0024 18.4 0.1 0.0045 17.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI86072.1 - 0.0039 17.5 0.3 0.017 15.4 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI86072.1 - 0.035 14.7 0.1 0.075 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KPI86072.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 KPI86072.1 - 0.11 12.2 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KPI86072.1 - 0.12 12.7 0.4 0.25 11.5 0.4 1.5 1 0 0 1 1 1 0 AAA domain Aldose_epim PF01263.20 KPI86076.1 - 1.5e-56 191.9 0.0 1.8e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase CTP_transf_like PF01467.26 KPI86077.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase-like FtsX PF02687.21 KPI86078.1 - 3.8e-14 52.9 19.8 1.9e-08 34.7 9.8 6.9 7 0 0 7 7 7 3 FtsX-like permease family DnaJ PF00226.31 KPI86079.1 - 1.8e-10 40.8 0.0 3.4e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Babuvirus_MP PF07234.11 KPI86079.1 - 0.0051 17.0 0.3 0.01 16.0 0.3 1.4 1 0 0 1 1 1 1 Movement and RNA silencing protein AC_N PF16214.5 KPI86079.1 - 0.29 10.2 2.2 0.46 9.6 2.2 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DEAD PF00270.29 KPI86080.1 - 1.9e-42 145.0 0.0 3e-41 141.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI86080.1 - 8.3e-32 109.8 0.1 1.7e-31 108.8 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KPI86080.1 - 0.0069 15.6 0.1 0.012 14.8 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 KPI86080.1 - 0.045 14.0 0.3 0.38 11.0 0.3 2.3 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 KPI86082.1 - 0.00019 22.1 2.6 0.31 12.0 0.0 5.2 4 0 0 4 4 4 1 WD domain, G-beta repeat Nup160 PF11715.8 KPI86082.1 - 0.022 13.5 0.0 0.038 12.6 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Dynein_light PF01221.18 KPI86083.1 - 8.6e-13 48.4 0.3 2.6e-12 46.9 0.3 1.8 1 1 0 1 1 1 1 Dynein light chain type 1 IPK PF03770.16 KPI86084.1 - 2.5e-21 76.5 0.0 3.5e-20 72.7 0.0 2.1 1 1 0 1 1 1 1 Inositol polyphosphate kinase EF-hand_1 PF00036.32 KPI86086.1 - 0.0012 18.3 0.0 0.044 13.4 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KPI86086.1 - 0.0077 16.1 0.0 0.11 12.4 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 KPI86086.1 - 0.023 15.2 0.0 0.059 13.8 0.0 1.7 1 1 0 1 1 1 0 EF-hand domain pair Flavokinase PF01687.17 KPI86087.1 - 1.1e-25 90.1 0.0 1.4e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Pkinase PF00069.25 KPI86088.1 - 1.5e-40 139.2 0.0 4.2e-40 137.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86088.1 - 4.5e-17 62.2 0.0 2.2e-15 56.7 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI86088.1 - 6.4e-06 25.2 0.0 1.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI86088.1 - 0.00033 20.7 0.1 0.0011 18.9 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI86088.1 - 0.0015 17.9 0.0 0.003 16.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family 2-ph_phosp PF04029.14 KPI86088.1 - 0.14 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase His_Phos_1 PF00300.22 KPI86090.1 - 8.7e-11 41.9 0.1 1.2e-08 34.9 0.0 2.6 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AvrD PF05655.11 KPI86090.1 - 0.062 12.6 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) RRM_1 PF00076.22 KPI86091.1 - 1e-05 25.3 0.0 2.3e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAM2 PF07145.15 KPI86091.1 - 0.018 14.7 0.0 0.079 12.7 0.0 2.2 1 0 0 1 1 1 0 Ataxin-2 C-terminal region EF-hand_13 PF17958.1 KPI86092.1 - 3.8e-17 61.9 0.0 7.1e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KPI86092.1 - 2.4e-12 47.1 0.1 2.2e-11 44.1 0.1 2.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI86092.1 - 0.015 14.8 3.6 0.37 10.4 0.1 3.4 3 0 0 3 3 3 0 EF hand EF-hand_6 PF13405.6 KPI86092.1 - 0.036 14.0 1.4 0.21 11.6 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 KPI86092.1 - 0.14 12.0 7.2 1.9 8.4 0.5 3.3 3 0 0 3 3 3 0 EF-hand domain pair Popeye PF04831.13 KPI86092.1 - 0.16 12.1 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Popeye protein conserved region EF-hand_5 PF13202.6 KPI86092.1 - 0.31 10.6 0.9 0.93 9.1 0.0 2.3 3 0 0 3 3 3 0 EF hand Cys_Met_Meta_PP PF01053.20 KPI86094.1 - 4.8e-128 426.9 0.1 5.4e-128 426.8 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 KPI86094.1 - 7.2e-12 45.3 1.2 7.2e-12 45.3 1.2 1.8 1 1 1 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 KPI86094.1 - 1.7e-07 30.6 0.4 2.3e-07 30.1 0.4 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 KPI86094.1 - 4.2e-07 29.5 0.1 5.6e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KPI86094.1 - 9.5e-05 21.8 0.5 0.00016 21.1 0.5 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DUF3586 PF12131.8 KPI86094.1 - 0.12 12.6 1.8 0.42 10.9 1.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3586) Fic PF02661.18 KPI86095.1 - 1.4 9.8 7.7 2 9.3 0.2 4.4 2 2 1 3 3 3 0 Fic/DOC family AAA PF00004.29 KPI86096.1 - 6.4e-15 55.7 0.0 1.3e-14 54.7 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 KPI86096.1 - 3.3e-12 46.7 0.0 9.2e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KPI86096.1 - 4.4e-11 42.8 0.0 3.5e-08 33.4 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 KPI86096.1 - 3.4e-10 40.2 0.0 6.7e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 KPI86096.1 - 1.4e-06 28.2 0.0 3.6e-06 26.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KPI86096.1 - 1.2e-05 25.6 0.1 9.9e-05 22.6 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 KPI86096.1 - 1.9e-05 25.1 0.0 7.8e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KPI86096.1 - 6.3e-05 23.0 0.0 0.00019 21.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KPI86096.1 - 7.8e-05 22.7 0.0 0.00015 21.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KPI86096.1 - 9.7e-05 22.7 0.0 0.00022 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KPI86096.1 - 0.00014 21.8 0.0 0.0044 16.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain TniB PF05621.11 KPI86096.1 - 0.00019 20.9 0.1 0.012 15.0 0.0 2.3 2 1 0 2 2 2 1 Bacterial TniB protein AAA_23 PF13476.6 KPI86096.1 - 0.00022 21.8 0.0 0.00028 21.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KPI86096.1 - 0.0003 20.2 0.0 0.00054 19.4 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KPI86096.1 - 0.00058 19.6 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KPI86096.1 - 0.0013 18.5 0.0 0.0031 17.3 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 KPI86096.1 - 0.0022 18.3 0.0 0.01 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA C-terminal domain ATPase_2 PF01637.18 KPI86096.1 - 0.0037 17.2 0.0 0.0085 16.0 0.0 1.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_29 PF13555.6 KPI86096.1 - 0.0039 16.9 0.0 0.008 15.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 KPI86096.1 - 0.004 16.7 0.0 0.0085 15.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF2075 PF09848.9 KPI86096.1 - 0.0041 16.4 0.0 0.006 15.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 KPI86096.1 - 0.01 15.0 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MeaB PF03308.16 KPI86096.1 - 0.017 14.1 0.0 0.19 10.7 0.0 2.1 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ResIII PF04851.15 KPI86096.1 - 0.018 15.0 0.0 0.71 9.9 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 KPI86096.1 - 0.018 15.2 0.0 0.041 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KPI86096.1 - 0.022 14.5 0.0 0.055 13.2 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 KPI86096.1 - 0.022 14.6 0.0 0.18 11.7 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KPI86096.1 - 0.023 14.5 0.0 6.4 6.5 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.29 KPI86096.1 - 0.037 13.8 0.2 0.25 11.1 0.0 2.0 1 1 0 2 2 2 0 DEAD/DEAH box helicase RecR PF02132.15 KPI86096.1 - 0.04 13.5 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 RecR protein ABC_tran PF00005.27 KPI86096.1 - 0.073 13.6 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_2 PF07724.14 KPI86096.1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Pex19 PF04614.12 KPI86097.1 - 3e-14 53.4 9.4 3.5e-12 46.6 0.7 3.6 1 1 2 3 3 3 2 Pex19 protein family PPR_3 PF13812.6 KPI86097.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Pentatricopeptide repeat domain PPR_2 PF13041.6 KPI86097.1 - 0.21 11.8 0.1 0.7 10.1 0.1 1.9 1 0 0 1 1 1 0 PPR repeat family Sec2p PF06428.11 KPI86097.1 - 0.32 11.0 7.0 2 8.4 1.2 2.4 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p HrpJ PF07201.11 KPI86097.1 - 0.35 11.2 4.4 0.62 10.4 0.6 2.6 3 0 0 3 3 3 0 HrpJ-like domain PPR PF01535.20 KPI86097.1 - 0.98 9.8 2.9 1.7 9.0 0.1 2.8 2 1 1 3 3 3 0 PPR repeat PPR_1 PF12854.7 KPI86097.1 - 3.6 7.4 4.5 5.8 6.7 0.3 2.4 2 0 0 2 2 2 0 PPR repeat SGT1 PF07093.11 KPI86097.1 - 4.9 5.5 5.2 6.4 5.1 5.2 1.2 1 0 0 1 1 1 0 SGT1 protein Sporozoite_P67 PF05642.11 KPI86098.1 - 0.025 12.7 5.1 0.027 12.6 5.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Plant_tran PF04827.14 KPI86098.1 - 0.089 12.4 0.3 0.13 11.9 0.3 1.2 1 0 0 1 1 1 0 Plant transposon protein Pinin_SDK_memA PF04696.13 KPI86098.1 - 2.5 8.2 28.9 0.066 13.3 12.9 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Nop53 PF07767.11 KPI86098.1 - 9.6 5.5 31.3 1 8.7 16.1 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Meth_synt_2 PF01717.18 KPI86099.1 - 4.9e-158 525.5 0.0 1e-150 501.5 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 KPI86099.1 - 9.2e-119 396.6 0.0 3.7e-109 365.0 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain HAUS-augmin3 PF14932.6 KPI86099.1 - 0.02 14.5 0.1 0.04 13.5 0.1 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 MFS_1 PF07690.16 KPI86100.1 - 1.1e-12 47.6 40.2 2.7e-10 39.7 26.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 KPI86100.1 - 4.6e-11 42.7 10.2 4.6e-11 42.7 10.2 2.3 2 1 0 2 2 2 1 Nodulin-like Phytoreo_Pns PF05451.11 KPI86100.1 - 0.23 10.6 0.8 6.1 5.9 0.1 2.8 2 1 1 3 3 3 0 Phytoreovirus nonstructural protein Pns10/11 TssO PF17561.2 KPI86100.1 - 0.47 10.5 0.0 0.47 10.5 0.0 2.9 4 0 0 4 4 4 0 Type VI secretion system, TssO TMEM40 PF15817.5 KPI86100.1 - 5.6 6.7 8.4 14 5.5 0.1 2.9 2 0 0 2 2 2 0 Transmembrane protein 40 family P5CR_dimer PF14748.6 KPI86101.1 - 3.3e-36 123.7 0.5 4.9e-36 123.1 0.5 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 KPI86101.1 - 2.3e-12 47.3 0.0 5.4e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 KPI86101.1 - 0.00082 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 KPI86101.1 - 0.0011 19.1 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KPI86101.1 - 0.072 13.2 0.1 0.16 12.1 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Ribosomal_L44 PF00935.19 KPI86102.1 - 7.2e-32 109.7 8.9 1e-31 109.2 8.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Cpn60_TCP1 PF00118.24 KPI86103.1 - 1.2e-159 532.1 9.2 1.3e-159 532.0 9.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FeoB_Cyto PF17910.1 KPI86103.1 - 0.078 13.5 1.0 17 6.0 0.0 3.2 3 0 0 3 3 3 0 FeoB cytosolic helical domain AAA_6 PF12774.7 KPI86104.1 - 7.2e-142 472.2 0.0 7.9e-141 468.7 0.0 2.7 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 KPI86104.1 - 1.9e-135 452.7 1.2 5.8e-134 447.8 0.0 3.3 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 KPI86104.1 - 1.8e-111 373.1 5.8 1.8e-111 373.1 5.8 3.1 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI86104.1 - 9.6e-94 313.5 0.0 3.2e-93 311.8 0.0 2.0 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.7 KPI86104.1 - 1.6e-87 293.7 7.9 3.9e-87 292.5 7.9 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 KPI86104.1 - 1.3e-81 272.9 0.1 1.3e-81 272.9 0.1 3.1 3 0 0 3 3 3 1 ATP-binding dynein motor region Dynein_C PF18199.1 KPI86104.1 - 8.9e-77 258.3 0.2 3e-76 256.6 0.2 2.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KPI86104.1 - 1.8e-67 226.4 0.3 2.4e-62 209.6 0.1 3.7 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI86104.1 - 3.4e-46 157.0 0.0 8.6e-46 155.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI86104.1 - 7.7e-35 119.6 0.0 1.8e-21 76.5 0.0 4.8 4 0 0 4 4 4 2 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 KPI86104.1 - 1.6e-24 86.0 0.8 6.5e-24 84.0 0.1 2.6 2 0 0 2 2 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 KPI86104.1 - 8.3e-23 80.9 0.3 3.3e-22 78.9 0.3 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KPI86104.1 - 1.6e-21 76.8 0.0 5.4e-08 32.9 0.0 5.5 5 0 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KPI86104.1 - 1.9e-07 31.7 0.1 0.048 14.2 0.0 5.6 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 KPI86104.1 - 1.3e-06 28.8 0.0 0.089 13.2 0.0 3.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI86104.1 - 1.7e-06 28.6 5.7 0.21 12.0 0.1 6.5 6 1 1 7 7 6 1 AAA ATPase domain AAA_22 PF13401.6 KPI86104.1 - 2e-05 24.9 0.1 5.3 7.3 0.0 5.3 5 0 0 5 5 3 1 AAA domain AAA_30 PF13604.6 KPI86104.1 - 0.0004 20.2 1.3 1.3 8.7 0.0 4.1 4 0 0 4 4 4 1 AAA domain AAA_19 PF13245.6 KPI86104.1 - 0.00041 20.7 2.9 0.94 9.8 0.0 4.2 4 0 0 4 4 3 1 AAA domain Mg_chelatase PF01078.21 KPI86104.1 - 0.0035 16.8 0.5 0.37 10.1 0.0 4.0 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KPI86104.1 - 0.024 15.0 1.3 67 3.9 0.0 4.9 4 0 0 4 4 4 0 RNA helicase AAA_28 PF13521.6 KPI86104.1 - 0.038 14.2 1.5 32 4.7 0.0 4.1 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 KPI86104.1 - 0.091 12.8 0.5 29 4.7 0.0 3.5 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 KPI86104.1 - 0.094 12.4 0.1 0.92 9.2 0.0 2.7 3 0 0 3 3 2 0 IstB-like ATP binding protein ABC_tran PF00005.27 KPI86104.1 - 0.1 13.1 0.3 49 4.4 0.0 4.1 3 0 0 3 3 3 0 ABC transporter FlaC_arch PF05377.11 KPI86104.1 - 0.21 12.0 1.7 8.1 6.9 0.1 4.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) NACHT PF05729.12 KPI86104.1 - 0.75 9.7 4.0 30 4.5 0.0 4.2 5 0 0 5 5 3 0 NACHT domain Phage_HK97_TLTM PF06120.11 KPI86104.1 - 2.3 7.3 16.1 0.04 13.1 0.1 4.1 4 0 0 4 4 4 0 Tail length tape measure protein FliD_N PF02465.18 KPI86104.1 - 2.9 8.6 11.8 1.3 9.8 0.8 4.5 4 0 0 4 4 3 0 Flagellar hook-associated protein 2 N-terminus Pkinase PF00069.25 KPI86105.1 - 1.3e-51 175.5 0.0 1.5e-29 103.2 0.0 3.5 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86105.1 - 9.4e-22 77.5 0.0 9.4e-17 61.1 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 KPI86105.1 - 4.9e-06 25.7 0.0 7.3e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI86105.1 - 0.02 14.8 0.3 0.19 11.6 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI86105.1 - 0.026 13.9 0.1 0.11 11.8 0.0 2.0 3 0 0 3 3 3 0 Kinase-like Kdo PF06293.14 KPI86105.1 - 0.085 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_A PF00476.20 KPI86106.1 - 5.5e-37 127.7 0.3 1.2e-36 126.6 0.1 1.6 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 KPI86106.1 - 0.00067 19.4 0.1 0.0042 16.8 0.0 2.4 3 0 0 3 3 3 1 3'-5' exonuclease IF2_N PF04760.15 KPI86106.1 - 0.15 11.9 0.1 7.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region SE PF08491.10 KPI86107.1 - 2.3e-57 194.2 0.0 3.2e-57 193.7 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 KPI86107.1 - 1.5e-08 34.3 0.0 4.4e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain GDI PF00996.18 KPI86107.1 - 0.0012 17.4 0.0 0.0018 16.9 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor Pyr_redox_2 PF07992.14 KPI86107.1 - 0.039 13.2 0.0 0.13 11.5 0.0 1.8 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI86107.1 - 0.13 12.5 0.0 0.45 10.8 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Kinesin PF00225.23 KPI86108.1 - 9.7e-92 307.4 0.0 1.8e-91 306.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI86108.1 - 6.5e-15 55.4 0.0 1.6e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding SAM_1 PF00536.30 KPI86108.1 - 0.0014 19.0 0.1 0.0014 19.0 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) BLOC1_2 PF10046.9 KPI86108.1 - 0.15 12.4 0.2 0.15 12.4 0.2 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spt20 PF12090.8 KPI86108.1 - 0.72 9.4 12.7 1.4 8.4 12.7 1.4 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 KPI86108.1 - 1.2 9.1 17.7 0.091 12.7 10.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Matrilin_ccoil PF10393.9 KPI86109.1 - 1.2 9.1 5.4 1.4 8.9 0.1 4.0 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin DELLA PF12041.8 KPI86109.1 - 3.3 7.7 11.2 0.11 12.4 0.9 3.7 3 0 0 3 3 3 0 Transcriptional regulator DELLA protein N terminal Tcp10_C PF07202.13 KPI86110.1 - 3.1e-26 92.4 1.5 5.6e-26 91.5 0.1 2.1 2 0 0 2 2 2 1 T-complex protein 10 C-terminus Seadorna_VP6 PF07407.11 KPI86110.1 - 0.34 9.8 0.5 0.52 9.2 0.5 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein UQ_con PF00179.26 KPI86111.1 - 4.2e-15 55.6 0.0 4.8e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KPI86111.1 - 0.049 13.9 0.0 0.056 13.7 0.0 1.2 1 0 0 1 1 1 0 RWD domain GRP PF07172.11 KPI86112.1 - 0.0079 16.9 0.5 0.0079 16.9 0.5 2.8 3 0 0 3 3 3 1 Glycine rich protein family TMEM208_SND2 PF05620.11 KPI86112.1 - 0.23 11.2 1.6 1.3 8.8 0.1 2.2 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 2OG-FeII_Oxy_2 PF13532.6 KPI86113.1 - 1.7e-06 28.4 0.1 5.3e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Thioredoxin PF00085.20 KPI86114.1 - 4.6e-29 100.4 0.1 5.4e-29 100.2 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KPI86114.1 - 1.9e-06 27.5 0.2 2.2e-06 27.3 0.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KPI86114.1 - 1.9e-05 25.1 0.2 7.3e-05 23.2 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_6 PF13848.6 KPI86114.1 - 5.9e-05 23.1 0.4 0.12 12.3 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain TraF PF13728.6 KPI86114.1 - 0.00021 21.2 0.0 0.00026 20.9 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KPI86114.1 - 0.001 19.2 0.0 0.0015 18.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_5 PF13743.6 KPI86114.1 - 0.0014 18.3 0.2 0.42 10.3 0.1 2.1 1 1 1 2 2 2 2 Thioredoxin Redoxin PF08534.10 KPI86114.1 - 0.0016 18.1 0.2 0.0024 17.6 0.2 1.3 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KPI86114.1 - 0.0021 18.0 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family ERp29_N PF07912.13 KPI86114.1 - 0.0025 18.0 0.1 0.0055 16.8 0.1 1.6 1 1 0 1 1 1 1 ERp29, N-terminal domain Thioredoxin_8 PF13905.6 KPI86114.1 - 0.013 15.8 0.1 0.093 13.1 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_9 PF14595.6 KPI86114.1 - 0.031 14.1 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin LOH1CR12 PF10158.9 KPI86115.1 - 1.6 8.8 19.5 0.93 9.5 3.9 4.2 4 1 0 4 4 4 0 Tumour suppressor protein HlyD_2 PF12700.7 KPI86115.1 - 1.6 7.4 7.5 0.13 11.0 2.2 1.8 2 0 0 2 2 2 0 HlyD family secretion protein Kinesin PF00225.23 KPI86116.1 - 6.1e-66 222.6 0.0 3.8e-65 220.0 0.0 2.1 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI86116.1 - 3.7e-14 52.9 0.0 7.1e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding HAUS-augmin3 PF14932.6 KPI86116.1 - 0.014 15.0 0.6 0.014 15.0 0.6 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 AAA_16 PF13191.6 KPI86116.1 - 0.018 15.4 1.4 0.09 13.2 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain BRE1 PF08647.11 KPI86116.1 - 0.032 14.3 6.6 0.068 13.2 6.6 1.5 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase AAA_7 PF12775.7 KPI86116.1 - 0.049 13.1 0.0 0.093 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF87 PF01935.17 KPI86116.1 - 0.098 12.7 1.2 0.42 10.7 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain SKA1 PF07160.12 KPI86116.1 - 0.12 12.3 4.4 0.19 11.6 4.4 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 G-patch PF01585.23 KPI86117.1 - 5.4e-13 48.6 0.9 9.2e-13 47.9 0.9 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KPI86117.1 - 1e-06 28.7 0.3 3.9e-06 26.9 0.3 1.9 1 0 0 1 1 1 1 G-patch domain SET PF00856.28 KPI86119.1 - 1.4e-14 54.9 0.0 3e-14 53.8 0.0 1.6 2 0 0 2 2 2 1 SET domain zf-MYND PF01753.18 KPI86119.1 - 2e-05 24.6 13.1 2e-05 24.6 13.1 3.1 3 0 0 3 3 3 1 MYND finger WD40 PF00400.32 KPI86121.1 - 9.4e-06 26.3 0.8 0.04 14.8 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat LRR_8 PF13855.6 KPI86122.1 - 1.2e-23 82.7 17.3 3.6e-08 33.0 0.3 4.8 5 0 0 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KPI86122.1 - 7.9e-12 45.2 21.9 0.0014 18.9 0.2 6.5 4 3 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI86122.1 - 8.1e-05 22.7 19.4 19 6.3 0.0 9.4 9 1 1 10 10 10 3 Leucine Rich Repeat LRR_6 PF13516.6 KPI86122.1 - 0.0086 16.0 24.2 3.8 7.8 0.1 8.5 8 0 0 8 8 8 2 Leucine Rich repeat LRR_9 PF14580.6 KPI86122.1 - 0.017 14.6 3.2 0.96 8.9 0.6 3.3 3 0 0 3 3 3 0 Leucine-rich repeat GRDP-like PF07173.12 KPI86122.1 - 0.048 14.3 3.7 47 4.6 0.1 4.3 3 1 1 4 4 4 0 Glycine-rich domain-containing protein-like DUF3883 PF13020.6 KPI86123.1 - 2.5e-16 59.5 0.0 4.5e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) Mob1_phocein PF03637.17 KPI86124.1 - 8.3e-70 234.2 0.2 1e-69 233.9 0.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family SIS PF01380.22 KPI86125.1 - 8.6e-47 158.3 0.3 1.2e-24 86.6 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KPI86125.1 - 6.9e-16 58.7 0.0 1.6e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KPI86125.1 - 8.6e-09 35.4 0.0 2e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KPI86125.1 - 0.00016 20.7 0.2 0.00036 19.5 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Fer4_20 PF14691.6 KPI86125.1 - 0.12 12.1 0.3 0.28 10.9 0.3 1.5 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster TLD PF07534.16 KPI86126.1 - 1.7e-08 34.8 0.0 3.7e-05 24.0 0.0 3.1 3 0 0 3 3 3 3 TLD Oxidored_FMN PF00724.20 KPI86127.1 - 8e-41 140.4 0.0 1.2e-40 139.9 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.14 KPI86127.1 - 9.6e-18 64.4 0.0 1.7e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI86127.1 - 2.3e-10 40.5 0.0 1.2e-09 38.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KPI86127.1 - 4.3e-07 29.0 1.6 5.7e-06 25.3 0.2 2.9 2 1 1 3 3 3 1 HI0933-like protein FAD_binding_2 PF00890.24 KPI86127.1 - 2.9e-06 26.6 0.7 5.1e-06 25.8 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KPI86127.1 - 4.6e-06 26.5 0.6 1.2e-05 25.1 0.6 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KPI86127.1 - 5.2e-06 26.1 1.1 1.5e-05 24.6 1.3 1.6 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KPI86127.1 - 5.5e-06 26.9 0.9 0.00088 19.8 0.5 3.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KPI86127.1 - 0.0012 18.2 0.4 0.0077 15.5 0.2 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KPI86127.1 - 0.0016 17.6 0.2 0.0024 17.0 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 KPI86127.1 - 0.0045 16.3 0.1 0.0087 15.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Amino_oxidase PF01593.24 KPI86127.1 - 0.0063 15.9 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase ApbA PF02558.16 KPI86127.1 - 0.007 16.0 0.0 0.017 14.7 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 KPI86127.1 - 0.039 13.2 0.1 0.069 12.4 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_Gly3P_dh_N PF01210.23 KPI86127.1 - 0.051 13.5 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 KPI86127.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 KPI86127.1 - 0.063 13.3 0.2 0.2 11.6 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 KPI86127.1 - 0.16 12.4 0.2 2.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 KPI86127.1 - 0.18 11.4 0.1 0.46 10.0 0.1 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PTH2 PF01981.16 KPI86129.1 - 2e-46 157.1 0.8 2.6e-46 156.7 0.8 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF5634_N PF18672.1 KPI86129.1 - 0.1 12.3 1.8 0.5 10.1 0.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5634) PP2C PF00481.21 KPI86130.1 - 1.2e-21 77.5 0.4 2.8e-14 53.4 0.1 3.1 3 0 0 3 3 3 2 Protein phosphatase 2C SpoIIE PF07228.12 KPI86130.1 - 0.13 12.2 0.0 0.37 10.7 0.0 1.7 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Acyl-CoA_dh_1 PF00441.24 KPI86132.1 - 4.1e-49 166.6 4.0 6.8e-49 165.9 4.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KPI86132.1 - 4.2e-27 95.0 0.1 1.1e-26 93.7 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KPI86132.1 - 2.6e-25 88.4 0.3 5.6e-25 87.4 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KPI86132.1 - 1.3e-21 77.3 4.0 2.1e-21 76.6 4.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 KPI86132.1 - 0.024 14.3 0.5 0.15 11.7 0.5 2.1 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal ORC2 PF04084.14 KPI86135.1 - 0.00061 18.8 0.0 0.18 10.7 0.0 2.3 2 0 0 2 2 2 2 Origin recognition complex subunit 2 Peptidase_M16 PF00675.20 KPI86136.1 - 5.2e-42 143.3 0.1 1.8e-41 141.6 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KPI86136.1 - 1.7e-14 54.3 0.0 9.3e-13 48.6 0.0 3.3 3 1 0 3 3 3 1 Peptidase M16 inactive domain HSP70 PF00012.20 KPI86137.1 - 1.9e-25 89.1 6.0 8e-22 77.2 0.6 4.9 4 1 0 4 4 4 3 Hsp70 protein CPSF100_C PF13299.6 KPI86137.1 - 0.12 12.6 1.4 0.29 11.3 1.4 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Dicty_REP PF05086.12 KPI86137.1 - 8.6 4.2 5.6 15 3.4 5.6 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein EF-hand_8 PF13833.6 KPI86139.1 - 0.00092 19.0 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI86139.1 - 0.0011 18.4 0.0 0.062 12.9 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KPI86139.1 - 0.083 13.4 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Asp_protease PF09668.10 KPI86140.1 - 1.2e-55 186.5 0.3 1.8e-55 186.1 0.3 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KPI86140.1 - 1.4e-16 60.8 0.0 3.4e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease UBA_4 PF14555.6 KPI86140.1 - 3.5e-09 36.3 0.4 3.5e-09 36.3 0.4 2.7 3 0 0 3 3 3 1 UBA-like domain RVP_2 PF08284.11 KPI86140.1 - 1.5e-08 34.5 0.0 2.6e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KPI86140.1 - 1.2e-06 29.1 0.2 3.3e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 KPI86140.1 - 0.065 13.5 0.4 0.28 11.5 0.0 2.2 3 0 0 3 3 3 0 Retroviral aspartyl protease Pol_alpha_B_N PF08418.10 KPI86140.1 - 1.3 8.9 3.2 1.1 9.2 0.9 1.8 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal RabGAP-TBC PF00566.18 KPI86141.1 - 2.7e-24 86.0 0.0 5.6e-24 85.0 0.0 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 KPI86141.1 - 0.08 13.5 0.0 4.8 7.8 0.0 2.8 3 0 0 3 3 3 0 Rhodanese-like domain RNA_ligase PF09414.10 KPI86142.1 - 8.2e-21 75.0 0.0 1.1e-20 74.5 0.0 1.2 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 KPI86142.1 - 3.4e-06 27.1 0.0 6.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal Mtc PF03820.17 KPI86144.1 - 7.2e-88 294.6 0.4 8.1e-88 294.4 0.4 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier PRP3 PF08572.10 KPI86145.1 - 1.2e-15 57.8 3.2 7e-15 55.4 3.1 2.1 1 1 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 KPI86145.1 - 6.8e-11 42.5 0.0 2e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) zf-CCHC_3 PF13917.6 KPI86146.1 - 2e-08 34.1 11.5 0.0011 18.8 0.1 3.4 3 0 0 3 3 3 3 Zinc knuckle Zn-ribbon_8 PF09723.10 KPI86146.1 - 0.85 9.8 7.5 9.2 6.5 0.1 3.4 3 0 0 3 3 3 0 Zinc ribbon domain zinc-ribbons_6 PF07191.12 KPI86146.1 - 1 9.4 12.2 3.1 7.8 0.4 3.2 3 0 0 3 3 3 0 zinc-ribbons zf-CCHC PF00098.23 KPI86146.1 - 5.7 7.2 29.6 5.8 7.2 3.1 3.3 3 0 0 3 3 3 0 Zinc knuckle Cys_rich_CPXG PF14255.6 KPI86146.1 - 8.4 6.4 9.3 0.65 9.9 0.1 3.0 3 0 0 3 3 3 0 Cysteine-rich CPXCG AMP-binding PF00501.28 KPI86148.1 - 1.2e-48 165.8 1.0 7e-30 104.0 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme AMP-binding PF00501.28 KPI86149.1 - 8.7e-92 307.9 1.1 9.6e-92 307.8 0.4 1.4 2 0 0 2 2 2 1 AMP-binding enzyme DUF3147 PF11345.8 KPI86150.1 - 0.01 16.2 2.2 0.018 15.4 2.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3147) DUF2157 PF09925.9 KPI86150.1 - 0.069 12.9 7.7 0.088 12.6 7.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) DsbD_2 PF13386.6 KPI86150.1 - 0.95 9.4 6.3 0.63 10.0 0.7 2.0 1 1 1 2 2 2 0 Cytochrome C biogenesis protein transmembrane region DUF3959 PF13105.6 KPI86151.1 - 0.52 9.8 3.4 0.59 9.6 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) IFT46_B_C PF12317.8 KPI86152.1 - 7.1e-79 264.4 0.0 9.3e-79 264.1 0.0 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Pkinase PF00069.25 KPI86153.1 - 6.1e-30 104.5 0.0 3.1e-29 102.2 0.0 2.2 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86153.1 - 8.7e-08 31.8 0.0 0.00087 18.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KPI86153.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI86153.1 - 0.006 15.9 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KPI86153.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DnaJ PF00226.31 KPI86154.1 - 2.1e-18 66.2 0.0 3.7e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain TGT PF01702.18 KPI86155.1 - 9.8e-125 416.3 0.0 3.9e-93 312.4 0.0 2.1 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase ASH PF15780.5 KPI86156.1 - 4.1e-61 203.3 55.7 4.2e-05 23.7 2.8 32.2 37 1 0 37 37 37 13 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 KPI86156.1 - 4e-20 71.9 17.2 0.033 14.4 0.0 14.4 16 0 0 16 16 16 5 Flagellar-associated PapD-like DUF1573 PF07610.11 KPI86156.1 - 3.6e-15 55.8 0.0 0.21 11.6 0.0 13.4 16 0 0 16 16 16 2 Protein of unknown function (DUF1573) DUF5001 PF16392.5 KPI86156.1 - 3.2e-07 30.2 1.0 0.0088 15.9 0.1 6.9 7 0 0 7 7 7 1 Ig-like domain Motile_Sperm PF00635.26 KPI86156.1 - 3.6e-07 30.0 3.4 6.4 6.7 0.0 10.5 11 0 0 11 11 11 1 MSP (Major sperm protein) domain AAA_16 PF13191.6 KPI86156.1 - 0.0036 17.7 0.1 0.01 16.2 0.1 1.8 1 0 0 1 1 1 1 AAA ATPase domain MYCBPAP PF14646.6 KPI86156.1 - 0.0086 15.1 0.2 21 3.9 0.0 5.6 7 1 0 7 7 7 0 MYCBP-associated protein family AAA_33 PF13671.6 KPI86156.1 - 0.014 15.5 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Transglut_C PF00927.22 KPI86156.1 - 0.02 15.0 1.0 15 5.8 0.0 5.8 6 0 0 6 6 4 0 Transglutaminase family, C-terminal ig like domain PapD_N PF00345.20 KPI86156.1 - 0.022 14.7 0.1 3.2 7.7 0.1 3.7 2 0 0 2 2 2 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain TMEM131_like PF12371.8 KPI86156.1 - 0.025 14.8 15.5 16 5.8 0.0 10.3 13 0 0 13 13 12 0 Transmembrane protein 131-like BclA_C PF18573.1 KPI86156.1 - 3.1 7.7 10.7 0.91 9.4 0.0 4.3 4 0 0 4 4 4 0 BclA C-terminal domain DUF3449 PF11931.8 KPI86157.1 - 1.3e-38 132.6 0.1 7.2e-38 130.2 0.1 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 KPI86157.1 - 3.8e-09 36.9 0.0 6.9e-07 29.7 0.0 3.0 2 1 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 PI3_PI4_kinase PF00454.27 KPI86159.1 - 2.8e-09 37.2 0.1 2e-07 31.1 0.1 2.3 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FYVE PF01363.21 KPI86159.1 - 1.1e-08 35.1 7.6 1.1e-08 35.1 7.6 2.7 2 0 0 2 2 2 1 FYVE zinc finger IBR PF01485.21 KPI86159.1 - 0.11 12.7 2.5 0.52 10.6 2.5 2.2 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2HC_2 PF13913.6 KPI86159.1 - 0.43 10.5 3.5 0.6 10.1 0.2 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type OrfB_Zn_ribbon PF07282.11 KPI86159.1 - 1.4 8.9 7.6 0.64 10.0 3.5 2.5 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 KPI86159.1 - 4.3 6.9 5.9 5.7 6.5 1.9 3.1 3 1 0 3 3 3 0 zinc-ribbon domain PBP1_TM PF14812.6 KPI86160.1 - 1.3 9.4 6.0 0.54 10.7 2.3 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cytochrome_C7 PF14522.6 KPI86162.1 - 0.048 13.7 0.1 0.093 12.7 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c AAA_18 PF13238.6 KPI86163.1 - 4e-30 105.0 0.1 6.3e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KPI86163.1 - 1.2e-08 35.5 0.2 3.9e-08 33.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KPI86163.1 - 3.4e-06 27.4 0.3 6e-05 23.3 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI86163.1 - 3.8e-06 27.1 0.0 0.00084 19.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KPI86163.1 - 6.1e-06 26.7 0.9 3.5e-05 24.2 0.9 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 KPI86163.1 - 0.00022 21.1 1.1 0.26 11.1 0.1 2.2 1 1 1 2 2 2 2 Deoxynucleoside kinase NTPase_1 PF03266.15 KPI86163.1 - 0.00035 20.5 0.1 0.0013 18.6 0.0 1.9 1 1 1 2 2 2 1 NTPase AAA_22 PF13401.6 KPI86163.1 - 0.00037 20.8 0.1 0.00054 20.3 0.1 1.6 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 KPI86163.1 - 0.00037 20.7 1.5 0.0026 17.9 1.5 2.1 1 1 0 1 1 1 1 Shikimate kinase RuvB_N PF05496.12 KPI86163.1 - 0.00061 19.6 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI86163.1 - 0.00069 20.0 0.0 0.00079 19.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain ADK PF00406.22 KPI86163.1 - 0.0027 17.8 0.1 0.23 11.6 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase RNA_helicase PF00910.22 KPI86163.1 - 0.0029 18.0 0.0 0.0057 17.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 KPI86163.1 - 0.0038 17.0 0.4 0.02 14.6 0.3 2.1 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI86163.1 - 0.0047 16.9 0.0 0.014 15.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KPI86163.1 - 0.0047 16.3 0.1 0.042 13.2 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI KTI12 PF08433.10 KPI86163.1 - 0.0072 15.8 0.0 0.015 14.8 0.0 1.5 2 0 0 2 2 2 1 Chromatin associated protein KTI12 ATPase PF06745.13 KPI86163.1 - 0.0092 15.4 0.6 0.016 14.5 0.0 1.7 2 0 0 2 2 2 1 KaiC Zeta_toxin PF06414.12 KPI86163.1 - 0.0092 15.3 0.0 0.017 14.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.9 KPI86163.1 - 0.0094 15.2 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 KPI86163.1 - 0.0098 15.8 0.1 0.017 15.0 0.1 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 KPI86163.1 - 0.015 14.6 0.0 0.02 14.1 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain Parvo_NS1 PF01057.17 KPI86163.1 - 0.015 14.4 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 KPI86163.1 - 0.016 15.5 0.3 0.044 14.1 0.1 1.7 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 KPI86163.1 - 0.018 14.8 0.4 0.1 12.4 0.4 2.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.27 KPI86163.1 - 0.023 15.2 1.3 0.14 12.7 1.3 2.1 1 1 0 1 1 1 0 ABC transporter TIP49 PF06068.13 KPI86163.1 - 0.023 13.9 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain CoaE PF01121.20 KPI86163.1 - 0.028 14.1 0.0 3.8 7.1 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase Sigma54_activat PF00158.26 KPI86163.1 - 0.028 14.1 0.1 0.06 13.0 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 KPI86163.1 - 0.039 13.7 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein APS_kinase PF01583.20 KPI86163.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_7 PF12775.7 KPI86163.1 - 0.046 13.2 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 KPI86163.1 - 0.047 13.4 0.4 2.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase AAA_2 PF07724.14 KPI86163.1 - 0.048 13.8 0.1 0.13 12.4 0.1 1.7 1 1 1 2 2 2 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 KPI86163.1 - 0.059 13.5 0.0 0.16 12.1 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain Torsin PF06309.11 KPI86163.1 - 0.063 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Torsin AAA_3 PF07726.11 KPI86163.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PUD1_2 PF18457.1 KPI86163.1 - 0.083 12.9 0.0 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 Up-Regulated in long-lived daf-2 ResIII PF04851.15 KPI86163.1 - 0.11 12.6 0.1 0.16 11.9 0.1 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 KPI86163.1 - 0.11 12.5 0.1 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KPI86163.1 - 0.11 12.1 0.1 0.94 9.0 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KPI86163.1 - 0.14 11.8 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI86163.1 - 0.21 11.3 0.1 0.38 10.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SPT2 PF08243.11 KPI86163.1 - 7.3 7.2 9.1 2.5 8.7 1.1 2.7 2 1 1 3 3 3 0 SPT2 chromatin protein CoA_trans PF01144.23 KPI86166.1 - 9.6e-79 263.8 5.1 3.2e-51 173.8 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Mal_decarbox_Al PF16957.5 KPI86166.1 - 0.00075 17.9 0.0 0.0013 17.2 0.0 1.3 1 0 0 1 1 1 1 Malonate decarboxylase, alpha subunit, transporter DeoRC PF00455.22 KPI86166.1 - 0.029 14.3 0.0 0.082 12.8 0.0 1.8 1 0 0 1 1 1 0 DeoR C terminal sensor domain ADK PF00406.22 KPI86167.1 - 1.6e-38 132.1 0.0 2.8e-38 131.4 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KPI86167.1 - 1.7e-19 70.6 0.0 6.1e-19 68.8 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI86167.1 - 5.4e-06 27.0 0.1 3.5e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI86167.1 - 0.0099 16.0 0.1 0.051 13.7 0.0 2.1 2 1 0 2 2 2 1 AAA domain ADK_lid PF05191.14 KPI86167.1 - 0.077 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid KTI12 PF08433.10 KPI86167.1 - 0.15 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 LRR_6 PF13516.6 KPI86168.1 - 1.5e-07 30.9 0.2 0.29 11.3 0.4 3.7 3 0 0 3 3 3 2 Leucine Rich repeat LRR_8 PF13855.6 KPI86168.1 - 0.064 13.0 3.7 2.5 7.9 1.5 3.0 2 1 0 2 2 2 0 Leucine rich repeat LRR_1 PF00560.33 KPI86168.1 - 0.19 12.4 2.2 18 6.4 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 KPI86168.1 - 0.23 12.0 3.6 0.56 10.7 0.6 2.5 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) TERB2 PF15101.6 KPI86168.1 - 0.3 11.1 1.8 0.49 10.4 1.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NMO PF03060.15 KPI86171.1 - 2.2e-61 208.1 1.0 1.2e-41 143.2 0.9 2.0 1 1 1 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 KPI86171.1 - 1.5e-10 40.6 0.1 4.4e-06 25.9 0.7 2.1 1 1 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KPI86171.1 - 2.1e-09 36.9 0.4 3.2e-09 36.3 0.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase ThiG PF05690.14 KPI86171.1 - 1.1e-06 28.2 0.5 1.6e-06 27.6 0.5 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 KPI86171.1 - 1.4e-06 27.8 0.0 1.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 KPI86171.1 - 0.00015 21.1 0.2 0.00022 20.5 0.2 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase DUF561 PF04481.12 KPI86171.1 - 0.011 14.9 0.1 0.019 14.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) His_biosynth PF00977.21 KPI86171.1 - 0.046 13.2 0.1 0.088 12.3 0.1 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein DUF1729 PF08354.10 KPI86171.1 - 0.049 12.5 0.1 0.19 10.6 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1729) RTT107_BRCT_6 PF16771.5 KPI86171.1 - 0.093 12.9 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Phostensin PF13914.6 KPI86172.1 - 0.05 14.2 1.5 7.5 7.2 0.0 3.6 3 0 0 3 3 3 0 Phostensin PP1-binding and SH3-binding region Exonuc_VII_L PF02601.15 KPI86172.1 - 8.6 5.8 17.1 22 4.5 17.1 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF641 PF04859.12 KPI86174.1 - 0.012 15.9 4.1 0.016 15.6 4.1 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) TSC22 PF01166.18 KPI86174.1 - 0.014 15.7 2.3 0.022 15.0 0.4 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family Syntaxin-6_N PF09177.11 KPI86174.1 - 0.15 12.6 3.7 0.22 12.1 2.4 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal SieB PF14163.6 KPI86174.1 - 0.16 11.5 1.2 0.27 10.7 1.2 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B SlyX PF04102.12 KPI86174.1 - 0.18 12.4 6.4 0.47 11.1 3.5 2.3 1 1 1 2 2 2 0 SlyX Csm1_N PF18504.1 KPI86174.1 - 0.22 11.9 10.0 1.8 9.0 3.7 2.5 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF4446 PF14584.6 KPI86174.1 - 0.63 10.0 4.0 0.59 10.1 1.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Cnn_1N PF07989.11 KPI86174.1 - 1.2 9.4 8.4 1.4 9.1 0.7 2.2 1 1 0 2 2 2 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 KPI86174.1 - 5.1 6.9 9.4 3.3 7.6 4.2 2.7 1 1 1 3 3 3 0 Septum formation initiator GTP_EFTU PF00009.27 KPI86175.1 - 2e-41 141.7 1.1 2.8e-41 141.2 0.2 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 KPI86175.1 - 2.3e-32 111.3 2.2 3.8e-32 110.6 2.2 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 KPI86175.1 - 4.1e-14 52.4 0.0 8.6e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 KPI86175.1 - 0.00047 20.2 0.0 0.0014 18.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 KPI86175.1 - 0.0043 17.4 0.0 0.0092 16.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 KPI86175.1 - 0.0062 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Ras family PduV-EutP PF10662.9 KPI86175.1 - 0.0079 15.9 0.0 0.063 13.0 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation IL11 PF07400.11 KPI86175.1 - 0.024 14.3 0.1 0.051 13.2 0.1 1.4 1 0 0 1 1 1 0 Interleukin 11 FeoB_N PF02421.18 KPI86175.1 - 0.16 11.5 0.2 0.33 10.5 0.2 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B LRR_4 PF12799.7 KPI86177.1 - 3e-06 27.4 17.7 1.3 9.5 0.2 6.1 4 2 1 6 6 6 4 Leucine Rich repeats (2 copies) MbeD_MobD PF04899.12 KPI86177.1 - 0.026 14.6 2.6 0.1 12.7 2.6 2.1 1 0 0 1 1 1 0 MbeD/MobD like CENP-F_leu_zip PF10473.9 KPI86177.1 - 0.077 13.0 2.6 10 6.2 0.5 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_prox PF18274.1 KPI86177.1 - 0.099 12.6 0.0 6.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Vacuolar ATPase Subunit I N-terminal proximal lobe WXG100 PF06013.12 KPI86177.1 - 1.1 9.6 8.5 8.1 6.8 0.5 3.4 3 0 0 3 3 3 0 Proteins of 100 residues with WXG SNAP PF14938.6 KPI86178.1 - 0.00053 19.5 15.4 0.00062 19.3 3.9 3.0 2 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP Clathrin PF00637.20 KPI86178.1 - 0.018 14.9 1.1 5.5 6.9 0.2 2.5 2 0 0 2 2 2 0 Region in Clathrin and VPS PRTP PF01366.18 KPI86178.1 - 0.023 12.7 0.6 0.034 12.2 0.6 1.2 1 0 0 1 1 1 0 Herpesvirus processing and transport protein TPR_2 PF07719.17 KPI86178.1 - 0.089 12.9 10.1 3.4 8.0 0.3 5.7 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI86178.1 - 1 9.3 3.6 3.8 7.5 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86178.1 - 1.7 9.0 10.2 0.54 10.6 0.4 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TOM20_plant PF06552.12 KPI86178.1 - 3.8 7.2 6.1 8.3 6.1 0.4 2.5 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 DUF952 PF06108.12 KPI86179.1 - 0.002 18.1 0.0 0.0042 17.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF952) DUF2868 PF11067.8 KPI86179.1 - 9.4 5.6 8.8 0.22 11.0 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) O-FucT PF10250.9 KPI86181.1 - 0.15 11.7 0.1 0.44 10.2 0.1 1.7 1 1 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Arginase PF00491.21 KPI86183.1 - 2.8e-72 243.6 0.0 3.2e-72 243.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family Transferase PF02458.15 KPI86184.1 - 2.5e-29 102.2 0.0 6.2e-28 97.6 0.0 2.4 1 1 0 1 1 1 1 Transferase family Condensation PF00668.20 KPI86184.1 - 0.013 14.2 0.0 0.019 13.6 0.0 1.1 1 0 0 1 1 1 0 Condensation domain NIF PF03031.18 KPI86186.1 - 9.3e-20 71.0 0.0 1.6e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase zf-CCCH PF00642.24 KPI86186.1 - 0.0084 16.0 3.1 0.0084 16.0 3.1 2.4 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RNA_pol_Rpb2_5 PF04567.17 KPI86187.1 - 0.0094 16.5 0.0 0.021 15.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF1635 PF07795.11 KPI86187.1 - 0.17 11.7 4.1 0.31 10.9 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Rieske PF00355.26 KPI86189.1 - 4.9e-12 45.6 0.0 8.7e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PIN_4 PF13638.6 KPI86190.1 - 0.034 14.4 0.0 0.067 13.5 0.0 1.6 1 0 0 1 1 1 0 PIN domain Rcd1 PF04078.13 KPI86191.1 - 0.078 12.3 0.1 0.27 10.5 0.1 1.8 2 0 0 2 2 2 0 Cell differentiation family, Rcd1-like Methyltransf_23 PF13489.6 KPI86192.1 - 2.9e-19 69.5 0.0 4.6e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI86192.1 - 1.2e-12 48.3 0.3 3.4e-12 46.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI86192.1 - 4.6e-11 43.3 0.0 9.6e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI86192.1 - 5.1e-09 35.8 0.0 7.7e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KPI86192.1 - 2.9e-07 31.1 0.0 1.2e-06 29.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI86192.1 - 5.1e-06 26.4 0.0 8.4e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_C14 PF00656.22 KPI86193.1 - 1.6e-50 172.4 0.0 2.1e-50 172.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Pro-rich PF15240.6 KPI86193.1 - 0.00065 20.0 33.3 0.001 19.4 33.3 1.2 1 0 0 1 1 1 1 Proline-rich Peptidase_C14 PF00656.22 KPI86194.1 - 7.3e-52 176.8 0.0 9.6e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 KPI86194.1 - 0.039 13.9 0.0 0.12 12.3 0.0 1.8 1 1 0 1 1 1 0 Raptor N-terminal CASPase like domain HemX PF04375.14 KPI86195.1 - 0.0072 15.6 3.2 0.0072 15.6 3.2 1.9 2 1 0 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase Spc7 PF08317.11 KPI86195.1 - 0.033 13.1 10.6 0.055 12.4 10.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.8 KPI86195.1 - 0.053 12.8 11.6 0.097 12.0 10.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Csm1 PF12539.8 KPI86195.1 - 0.059 14.0 0.2 0.25 12.0 0.0 2.2 2 0 0 2 2 1 0 Chromosome segregation protein Csm1/Pcs1 NPV_P10 PF05531.12 KPI86195.1 - 0.1 13.1 2.5 28 5.3 0.0 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 KPI86195.1 - 0.2 12.2 13.2 0.47 11.0 13.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_13 PF13166.6 KPI86195.1 - 0.2 10.3 6.6 0.36 9.4 6.6 1.3 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.12 KPI86195.1 - 0.22 11.5 7.6 0.19 11.7 3.4 2.5 1 1 1 2 2 2 0 Laminin Domain II Rbsn PF11464.8 KPI86195.1 - 0.25 11.1 5.0 4.8 7.0 0.6 3.2 3 1 0 3 3 3 0 Rabenosyn Rab binding domain DUF812 PF05667.11 KPI86195.1 - 0.54 9.1 10.1 0.48 9.2 8.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF16 PF01519.16 KPI86195.1 - 0.58 10.7 8.5 1 9.9 2.8 3.4 2 1 2 4 4 4 0 Protein of unknown function DUF16 DUF1664 PF07889.12 KPI86195.1 - 0.64 10.1 7.4 1.3 9.0 0.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BST2 PF16716.5 KPI86195.1 - 0.87 10.2 12.4 1.1 9.8 6.9 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 BLOC1_2 PF10046.9 KPI86195.1 - 1.1 9.6 8.8 5.8 7.3 5.1 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 THOC7 PF05615.13 KPI86195.1 - 1.2 9.4 13.5 2.7 8.3 6.1 2.5 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4200 PF13863.6 KPI86195.1 - 1.3 9.4 12.9 4.2 7.8 12.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) UPF0242 PF06785.11 KPI86195.1 - 1.3 9.1 8.2 1.9 8.5 7.4 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 KPI86195.1 - 1.4 9.1 14.8 0.63 10.2 6.5 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Uso1_p115_C PF04871.13 KPI86195.1 - 1.5 9.2 12.5 3.5 8.0 12.5 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region FapA PF03961.13 KPI86195.1 - 2.6 6.5 4.5 4.1 5.9 4.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Nucleopor_Nup85 PF07575.13 KPI86196.1 - 0.0023 16.6 0.0 0.0041 15.7 0.0 1.3 1 0 0 1 1 1 1 Nup85 Nucleoporin DUF3135 PF11333.8 KPI86196.1 - 0.053 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) DUF3168 PF11367.8 KPI86197.1 - 2.3 8.4 6.8 0.31 11.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3168) Laminin_G_3 PF13385.6 KPI86198.1 - 1.4e-10 41.5 0.0 3.3e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Cmc1 PF08583.10 KPI86198.1 - 0.25 11.4 3.0 1.1 9.4 3.0 2.1 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like EF-hand_7 PF13499.6 KPI86199.1 - 0.00063 20.1 0.0 0.043 14.3 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair PqqD PF05402.12 KPI86199.1 - 0.18 12.1 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Spem1 PF15670.5 KPI86199.1 - 4.2 6.9 8.9 8.9 5.8 8.9 1.5 1 0 0 1 1 1 0 Spermatid maturation protein 1 MutL_C PF08676.11 KPI86202.1 - 9.7e-29 100.0 0.0 2e-28 99.0 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 KPI86202.1 - 1.9e-11 43.7 0.0 3.7e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KPI86202.1 - 9.7e-09 35.2 0.0 3.5e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KPI86202.1 - 7.4e-05 23.2 0.0 0.00021 21.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OrsD PF12013.8 KPI86202.1 - 0.26 11.8 1.5 0.65 10.5 1.5 1.7 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D PPR_2 PF13041.6 KPI86203.1 - 0.025 14.8 0.2 0.61 10.3 0.1 3.0 2 1 1 3 3 3 0 PPR repeat family MIP PF00230.20 KPI86204.1 - 7.3e-33 114.2 17.5 9.1e-33 113.9 17.5 1.1 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.20 KPI86205.1 - 3.6e-29 102.1 16.3 4.9e-29 101.7 16.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein LapA_dom PF06305.11 KPI86205.1 - 3.3 7.6 5.8 3.5 7.5 0.5 3.2 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Nucleo_P87 PF07267.11 KPI86206.1 - 4 6.2 8.0 1 8.2 5.1 1.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Kelch_6 PF13964.6 KPI86208.1 - 7.1e-10 38.8 1.1 2.1e-05 24.6 0.1 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KPI86208.1 - 7.6e-08 32.2 0.1 0.0038 17.2 0.0 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KPI86208.1 - 1.1e-07 31.2 2.7 2.7e-07 30.0 0.1 3.0 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 KPI86208.1 - 4.8e-07 29.5 1.0 1.8e-05 24.5 0.2 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 KPI86208.1 - 6.5e-07 29.2 0.8 0.036 14.1 0.4 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KPI86208.1 - 0.0066 16.7 6.6 0.055 13.8 0.0 4.7 5 0 0 5 5 5 1 Galactose oxidase, central domain TPR_12 PF13424.6 KPI86209.1 - 4.8e-06 26.8 3.5 7.7e-06 26.1 1.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI86209.1 - 0.00073 19.3 1.0 0.12 12.2 0.4 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86209.1 - 0.67 10.1 4.5 15 5.9 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86209.1 - 4.5 7.6 8.6 4.3 7.7 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PRK PF00485.18 KPI86210.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Methyltr_RsmB-F PF01189.17 KPI86211.1 - 3.2e-26 92.2 0.0 4.6e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F MTS PF05175.14 KPI86211.1 - 0.2 11.2 0.0 0.45 10.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain NUDIX PF00293.28 KPI86212.1 - 0.0042 17.1 0.0 0.0083 16.2 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain RCR PF12273.8 KPI86212.1 - 0.32 11.7 2.1 0.83 10.3 2.1 1.7 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red PAP_assoc PF03828.19 KPI86213.1 - 1.8e-08 34.5 0.0 3.6e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KPI86213.1 - 0.032 14.5 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain ubiquitin PF00240.23 KPI86215.1 - 0.0099 15.6 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family PRP1_N PF06424.12 KPI86216.1 - 0.0031 17.9 1.6 0.0031 17.9 1.6 1.8 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal ANAPC3 PF12895.7 KPI86216.1 - 0.033 14.4 0.4 0.88 9.8 0.6 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5560 PF17715.1 KPI86216.1 - 0.083 12.3 0.0 0.083 12.3 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5560) TPR_2 PF07719.17 KPI86216.1 - 0.091 12.9 9.4 0.19 11.9 1.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86216.1 - 0.11 12.8 1.5 32 5.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KPI86216.1 - 0.23 11.9 3.3 25 5.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86216.1 - 0.5 11.3 0.0 0.5 11.3 0.0 11.2 10 3 4 14 14 14 0 Tetratricopeptide repeat TPR_20 PF14561.6 KPI86216.1 - 1.3 9.4 7.3 0.64 10.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Hrs_helical PF12210.8 KPI86220.1 - 0.22 12.1 8.7 0.55 10.8 8.7 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate cNMP_binding PF00027.29 KPI86221.1 - 1.7e-15 56.8 0.5 0.00014 21.9 0.0 5.9 4 2 1 5 5 5 4 Cyclic nucleotide-binding domain DUF2780 PF11075.8 KPI86221.1 - 0.048 13.8 0.2 0.69 10.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function VcgC/VcgE (DUF2780) HD PF01966.22 KPI86222.1 - 7e-08 32.7 0.0 1.9e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 HD domain ACAS_N PF16177.5 KPI86223.1 - 2.9e-18 65.5 6.8 2.8e-17 62.3 5.1 2.6 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding PF00501.28 KPI86223.1 - 8.8e-16 57.5 0.0 1.1e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Tyr-DNA_phospho PF06087.12 KPI86223.1 - 0.073 12.0 0.0 0.081 11.8 0.0 1.1 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase Dpy-30 PF05186.13 KPI86225.1 - 0.00032 20.3 0.1 0.0011 18.6 0.0 1.9 2 0 0 2 2 2 1 Dpy-30 motif RIIa PF02197.17 KPI86225.1 - 0.016 14.9 0.0 0.031 13.9 0.0 1.6 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit MHB PF16525.5 KPI86225.1 - 0.057 13.7 0.0 0.097 12.9 0.0 1.4 1 1 0 1 1 1 0 Haemophore, haem-binding Mtc PF03820.17 KPI86225.1 - 0.068 12.2 0.1 0.076 12.0 0.1 1.1 1 0 0 1 1 1 0 Tricarboxylate carrier DUF3775 PF12616.8 KPI86225.1 - 0.093 12.8 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) Pyr_redox_2 PF07992.14 KPI86226.1 - 8.3e-10 38.4 0.0 9.4e-08 31.6 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI86226.1 - 7.8e-06 26.0 0.1 2.9e-05 24.2 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KPI86226.1 - 0.00021 20.6 0.0 0.00036 19.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 KPI86226.1 - 0.00023 20.9 0.9 0.0026 17.4 0.3 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KPI86226.1 - 0.0025 16.9 1.0 0.0042 16.2 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 KPI86226.1 - 0.003 16.7 0.4 0.0063 15.6 0.4 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 KPI86226.1 - 0.0072 15.5 0.1 0.014 14.5 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 KPI86226.1 - 0.017 13.8 1.4 0.032 12.9 0.7 1.8 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 KPI86226.1 - 0.023 13.6 0.4 0.036 12.9 0.4 1.3 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 KPI86226.1 - 0.06 12.6 0.2 0.15 11.2 0.2 1.6 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 KPI86226.1 - 0.074 12.3 0.0 1.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 KPI86226.1 - 0.11 11.9 0.5 0.24 10.7 0.3 1.7 1 1 0 1 1 1 0 ThiF family PRMT5 PF05185.16 KPI86226.1 - 0.21 11.4 0.1 0.36 10.6 0.1 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase NAD_binding_9 PF13454.6 KPI86226.1 - 0.53 10.3 3.4 0.47 10.4 0.2 2.5 3 0 0 3 3 3 0 FAD-NAD(P)-binding Peptidase_C2 PF00648.21 KPI86227.1 - 2.4e-06 26.8 0.0 4.7e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease PLN_propep PF16485.5 KPI86227.1 - 0.014 15.1 0.1 0.13 12.0 0.1 2.3 2 0 0 2 2 2 0 Protealysin propeptide Mon1 PF03164.14 KPI86228.1 - 1.1e-31 110.4 0.0 7e-16 58.3 0.0 3.0 2 1 0 2 2 2 2 Trafficking protein Mon1 WD40 PF00400.32 KPI86229.1 - 5.6e-16 58.6 1.8 0.007 17.2 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 KPI86229.1 - 0.00025 19.8 0.0 0.38 9.3 0.0 2.9 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KPI86229.1 - 0.043 12.6 0.0 23 3.6 0.0 3.2 3 0 0 3 3 3 0 Nup133 N terminal like Ge1_WD40 PF16529.5 KPI86229.1 - 0.17 10.8 0.0 23 3.8 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GEN1_C PF18380.1 KPI86229.1 - 0.46 11.4 4.0 1.9 9.4 4.0 2.2 1 1 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain PseudoU_synth_1 PF01416.20 KPI86230.1 - 8.1e-10 39.1 0.0 6.4e-07 29.8 0.0 3.3 2 1 0 2 2 2 2 tRNA pseudouridine synthase SURF6 PF04935.12 KPI86230.1 - 2.3 8.0 14.1 4.4 7.0 14.1 1.4 1 0 0 1 1 1 0 Surfeit locus protein 6 START PF01852.19 KPI86231.1 - 0.0021 17.5 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 START domain DS PF01916.17 KPI86232.1 - 9.2e-58 195.8 0.0 3.1e-47 161.2 0.0 3.3 3 1 0 3 3 3 3 Deoxyhypusine synthase DUF702 PF05142.12 KPI86232.1 - 1.7 9.1 7.4 0.46 10.9 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF702) AAA PF00004.29 KPI86233.1 - 1.8e-11 44.6 0.0 1.7e-07 31.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KPI86233.1 - 7.8e-07 29.2 0.0 1.9e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI86233.1 - 0.002 18.6 1.3 0.0063 16.9 1.3 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KPI86233.1 - 0.0063 17.0 0.0 0.042 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 KPI86233.1 - 0.0087 15.2 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 KPI86233.1 - 0.01 16.1 0.1 0.036 14.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_6 PF12774.7 KPI86233.1 - 0.019 13.9 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_13 PF13166.6 KPI86233.1 - 0.02 13.5 0.1 0.036 12.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KPI86233.1 - 0.023 15.2 0.0 0.052 14.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KPI86233.1 - 0.028 14.2 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KPI86233.1 - 0.035 14.5 0.0 0.085 13.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 KPI86233.1 - 0.049 14.0 1.3 0.092 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 KPI86233.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KPI86233.1 - 0.07 12.5 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KPI86233.1 - 0.07 13.3 0.0 0.23 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KPI86233.1 - 0.13 12.6 0.0 0.41 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 KPI86233.1 - 0.14 12.0 0.0 2.8 7.8 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KPI86233.1 - 0.14 11.7 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KPI86233.1 - 0.17 12.2 0.1 0.95 9.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain eIF-5_eIF-2B PF01873.17 KPI86234.1 - 1.9e-32 111.6 0.1 4.2e-32 110.5 0.0 1.6 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.18 KPI86234.1 - 0.0079 16.3 0.0 0.028 14.5 0.0 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon CNDH2_M PF16869.5 KPI86234.1 - 0.028 15.1 0.2 0.043 14.5 0.2 1.3 1 0 0 1 1 1 0 PF16858 BCL9 PF11502.8 KPI86234.1 - 0.16 11.8 1.4 1.4 8.8 0.5 2.4 2 0 0 2 2 2 0 B-cell lymphoma 9 protein FYDLN_acid PF09538.10 KPI86234.1 - 4.3 8.1 8.5 5.6 7.7 3.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpb1_5 PF04998.17 KPI86235.1 - 1.3e-74 251.1 0.0 1.8e-74 250.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KPI86235.1 - 1.2e-67 227.3 0.8 3.5e-67 225.8 0.0 2.1 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 KPI86235.1 - 1.1e-58 199.1 0.0 1.6e-58 198.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 KPI86235.1 - 9.1e-32 110.2 0.0 2.5e-31 108.7 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KPI86235.1 - 2e-31 108.1 0.0 4.9e-31 106.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 COG6 PF06419.11 KPI86236.1 - 4.2e-46 157.4 0.0 2.2e-43 148.4 0.0 2.9 3 0 0 3 3 3 2 Conserved oligomeric complex COG6 Occludin_ELL PF07303.13 KPI86236.1 - 0.077 13.7 1.7 0.17 12.6 0.5 2.2 2 0 0 2 2 2 0 Occludin homology domain PNP_UDP_1 PF01048.20 KPI86237.1 - 0.051 12.8 0.6 1.3 8.3 0.0 2.6 2 0 0 2 2 2 0 Phosphorylase superfamily SAP130_C PF16014.5 KPI86237.1 - 0.15 11.1 1.5 0.25 10.4 1.5 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Ribosomal_S6 PF01250.17 KPI86239.1 - 0.003 17.8 0.1 0.0044 17.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 MT PF12777.7 KPI86240.1 - 0.0048 16.0 0.0 0.0068 15.5 0.0 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor TPR_MLP1_2 PF07926.12 KPI86240.1 - 0.0069 16.4 8.4 0.12 12.4 3.4 2.8 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein EzrA PF06160.12 KPI86240.1 - 0.012 13.9 0.4 0.012 13.9 0.4 1.8 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA COG2 PF06148.11 KPI86240.1 - 0.13 12.4 1.7 2.3 8.3 0.3 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 KPI86240.1 - 0.14 12.3 0.6 0.79 9.9 0.1 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.6 KPI86240.1 - 0.17 11.3 6.8 0.052 12.9 1.6 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ZapB PF06005.12 KPI86240.1 - 0.19 12.2 5.6 1.6 9.2 0.3 2.8 2 0 0 2 2 2 0 Cell division protein ZapB DUF4407 PF14362.6 KPI86240.1 - 0.2 11.0 6.4 0.39 10.0 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Med9 PF07544.13 KPI86240.1 - 0.21 11.7 1.3 0.37 10.9 0.1 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 ABATE PF07336.11 KPI86240.1 - 0.92 10.2 6.9 0.37 11.4 2.0 2.8 3 0 0 3 3 3 0 Putative stress-induced transcription regulator OEP PF02321.18 KPI86240.1 - 2.3 8.0 5.3 10 5.9 0.5 2.4 2 0 0 2 2 2 0 Outer membrane efflux protein KH_6 PF15985.5 KPI86243.1 - 1.6e-10 41.2 1.7 2e-10 40.8 0.2 2.0 2 0 0 2 2 2 1 KH domain YlbD_coat PF14071.6 KPI86243.1 - 0.0032 17.7 0.0 0.006 16.8 0.0 1.4 1 0 0 1 1 1 1 Putative coat protein Alpha-2-MRAP_N PF06400.11 KPI86243.1 - 0.14 12.2 0.1 0.24 11.4 0.1 1.3 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, N-terminal domain PI3_PI4_kinase PF00454.27 KPI86244.1 - 3.8e-48 164.5 0.0 3.9e-47 161.2 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KPI86244.1 - 6.8e-48 162.5 0.8 1.5e-47 161.4 0.8 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_rbd PF00794.18 KPI86244.1 - 1.1e-10 41.6 0.0 7e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 KPI86244.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 SNF2_N PF00176.23 KPI86246.1 - 5.1e-27 94.5 0.0 1.2e-26 93.3 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Tet_JBP PF12851.7 KPI86246.1 - 4.6e-22 78.8 0.1 1.5e-17 64.0 0.1 2.2 1 1 1 2 2 2 2 Oxygenase domain of the 2OGFeDO superfamily Helicase_C PF00271.31 KPI86246.1 - 3.4e-14 53.1 0.3 8.6e-14 51.8 0.3 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI86246.1 - 2.6e-13 50.3 0.0 5e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 KPI86246.1 - 7e-06 25.9 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DEAD PF00270.29 KPI86246.1 - 0.00017 21.4 0.0 0.00034 20.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KPI86246.1 - 0.00028 20.2 0.4 0.00054 19.3 0.4 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF2075 PF09848.9 KPI86246.1 - 0.0064 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) cNMP_binding PF00027.29 KPI86247.1 - 6.3e-08 32.6 0.0 0.27 11.3 0.0 4.3 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain Spt20 PF12090.8 KPI86247.1 - 8 6.0 11.1 15 5.1 11.1 1.3 1 0 0 1 1 1 0 Spt20 family Arf PF00025.21 KPI86248.1 - 7.8e-07 28.7 0.0 1.5e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_28 PF13521.6 KPI86248.1 - 0.052 13.8 0.3 0.085 13.1 0.1 1.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KPI86248.1 - 0.058 13.8 0.0 0.073 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DHHC PF01529.20 KPI86249.1 - 2.7e-22 79.3 12.9 2.7e-22 79.3 12.9 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Far-17a_AIG1 PF04750.14 KPI86249.1 - 0.0065 15.8 1.5 0.0065 15.8 1.5 1.8 2 0 0 2 2 2 1 FAR-17a/AIG1-like protein EpsG PF14897.6 KPI86249.1 - 0.082 12.2 7.0 0.016 14.5 3.4 1.7 2 0 0 2 2 2 0 EpsG family PRP1_N PF06424.12 KPI86250.1 - 0.088 13.2 0.2 0.088 13.2 0.2 1.7 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal ABC_trans_N PF14510.6 KPI86250.1 - 0.18 12.4 1.1 1.5 9.5 0.1 2.4 2 1 0 2 2 2 0 ABC-transporter N-terminal DnaJ PF00226.31 KPI86251.1 - 8.2e-06 25.9 0.1 2.3e-05 24.4 0.1 1.7 2 0 0 2 2 2 1 DnaJ domain Methyltransf_3 PF01596.17 KPI86252.1 - 0.0064 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase TbpB_A PF17484.2 KPI86252.1 - 0.11 13.2 0.1 0.35 11.6 0.0 1.8 2 0 0 2 2 2 0 N-Lobe handle Tf-binding protein B Spc24 PF08286.11 KPI86252.1 - 1.2 9.4 6.7 0.32 11.3 1.1 2.8 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 DnaJ PF00226.31 KPI86253.1 - 9.4e-14 51.3 0.6 1.7e-13 50.5 0.6 1.4 1 0 0 1 1 1 1 DnaJ domain IU_nuc_hydro PF01156.19 KPI86255.1 - 3.1e-68 230.6 0.1 3.6e-68 230.4 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MOZ_SAS PF01853.18 KPI86256.1 - 2.8e-62 209.5 0.0 5.6e-62 208.6 0.0 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KPI86256.1 - 1.9e-09 37.0 0.6 2.3e-05 23.9 0.1 2.5 2 0 0 2 2 2 2 MYST family zinc finger domain Tudor-knot PF11717.8 KPI86256.1 - 2.1e-08 33.9 0.0 5.5e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 KPI86256.1 - 0.0011 19.4 0.0 0.0029 18.0 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI86256.1 - 0.039 14.2 0.0 0.087 13.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family zf-C2H2_4 PF13894.6 KPI86256.1 - 0.047 14.6 0.3 0.21 12.5 0.3 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-Di19 PF05605.12 KPI86256.1 - 3.8 7.9 6.4 20 5.5 1.6 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ribosomal_L12 PF00542.19 KPI86257.1 - 6e-17 61.8 3.9 1.6e-16 60.4 3.9 1.8 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.19 KPI86257.1 - 0.16 12.6 14.2 0.035 14.7 9.8 2.1 1 1 1 2 2 2 0 60s Acidic ribosomal protein Ribosomal_L12_N PF16320.5 KPI86257.1 - 1.5 8.6 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain Chromo PF00385.24 KPI86258.1 - 0.0015 18.4 0.1 0.003 17.4 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 KPI86258.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Thioredoxin_8 PF13905.6 KPI86261.1 - 9.5e-10 38.7 0.1 1.6e-09 37.9 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 KPI86261.1 - 1.9e-05 24.4 0.3 2.5e-05 24.0 0.3 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KPI86261.1 - 7e-05 22.7 0.1 0.0001 22.2 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family BBIP10 PF14777.6 KPI86262.1 - 2.7e-20 71.7 2.9 3.8e-20 71.2 2.9 1.2 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 DUF5538 PF17692.1 KPI86262.1 - 2.7 8.1 8.1 3.8 7.6 7.3 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5538) KH_1 PF00013.29 KPI86263.1 - 1.1e-44 150.0 0.2 3.6e-10 39.5 0.1 6.4 6 0 0 6 6 6 5 KH domain KH_2 PF07650.17 KPI86263.1 - 1.8e-07 30.9 0.1 0.23 11.3 0.0 5.0 5 0 0 5 5 5 2 KH domain KH_4 PF13083.6 KPI86263.1 - 0.26 11.2 1.7 43 4.1 0.1 4.4 4 0 0 4 4 4 0 KH domain BON PF04972.17 KPI86263.1 - 0.43 10.9 2.8 0.67 10.3 0.1 2.9 3 0 0 3 3 3 0 BON domain OrfB_IS605 PF01385.19 KPI86263.1 - 3.2 8.0 6.5 1.1 9.5 0.1 2.8 2 1 0 2 2 2 0 Probable transposase DUF4201 PF13870.6 KPI86264.1 - 1.5e-27 96.4 14.1 1.5e-27 96.4 14.1 3.3 3 1 0 4 4 4 1 Domain of unknown function (DUF4201) TcpS PF17456.2 KPI86264.1 - 0.11 12.5 0.5 0.25 11.4 0.5 1.5 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S SRR1 PF07985.12 KPI86264.1 - 0.84 9.7 2.1 4.1 7.5 0.6 2.8 3 0 0 3 3 3 0 SRR1 Cnn_1N PF07989.11 KPI86264.1 - 0.91 9.7 15.9 0.21 11.7 7.0 4.0 4 1 0 4 4 4 0 Centrosomin N-terminal motif 1 Prp19 PF08606.11 KPI86264.1 - 1.7 8.7 12.2 1 9.4 0.1 4.0 4 0 0 4 4 4 0 Prp19/Pso4-like DUF1664 PF07889.12 KPI86264.1 - 4.4 7.4 8.1 12 5.9 2.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 KPI86264.1 - 5.2 7.4 20.7 0.32 11.3 5.0 4.8 5 1 1 6 6 6 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 KPI86264.1 - 6.7 7.0 5.4 22 5.4 0.0 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TMF_DNA_bd PF12329.8 KPI86264.1 - 6.8 6.8 15.0 8.5 6.5 7.5 3.9 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding APC_N_CC PF16689.5 KPI86264.1 - 7.5 6.7 8.5 24 5.1 3.8 3.2 1 1 1 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain PX PF00787.24 KPI86265.1 - 2.1e-10 40.5 0.1 7.8e-10 38.7 0.0 2.0 2 0 0 2 2 2 1 PX domain Sec5 PF15469.6 KPI86266.1 - 0.0091 15.8 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 HIT PF01230.23 KPI86267.1 - 1.1e-22 80.6 0.1 1.4e-22 80.2 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KPI86267.1 - 2e-12 47.6 0.0 2.6e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 KPI86267.1 - 0.00021 21.1 0.6 0.00063 19.6 0.6 1.8 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 TRAP-gamma PF07074.12 KPI86268.1 - 4.5e-07 29.6 7.8 0.0016 18.0 0.7 2.1 2 0 0 2 2 2 2 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF4386 PF14329.6 KPI86268.1 - 0.012 15.5 0.8 0.02 14.8 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4386) DUF2569 PF10754.9 KPI86268.1 - 0.028 14.9 4.0 0.038 14.4 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) LPG_synthase_TM PF03706.13 KPI86268.1 - 0.15 11.6 5.5 0.18 11.3 5.5 1.2 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region DUF3270 PF11674.8 KPI86268.1 - 6.2 7.1 8.1 0.46 10.7 0.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3270) VWA_3 PF13768.6 KPI86269.1 - 2.6e-10 40.4 0.1 8.8e-10 38.7 0.1 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 KPI86269.1 - 0.00017 21.4 0.2 0.00092 19.1 0.0 2.2 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain DAGK_acc PF00609.19 KPI86270.1 - 4e-40 137.8 0.0 6.4e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KPI86270.1 - 4.7e-16 58.6 0.2 1.1e-15 57.4 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 KPI86270.1 - 0.031 13.5 0.8 0.087 12.0 0.4 1.7 1 1 0 1 1 1 0 ATP-NAD kinase PPTA PF01239.22 KPI86271.1 - 5.5e-15 54.5 11.3 0.00069 19.3 0.3 5.4 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat DUF4592 PF15262.6 KPI86271.1 - 0.54 10.9 3.4 0.28 11.8 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4592) Fumerase_C PF05683.12 KPI86272.1 - 3.7e-89 297.5 0.0 6.1e-89 296.8 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 KPI86272.1 - 3.4e-80 269.3 0.0 4.4e-80 269.0 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) LmjF365940-deam PF14421.6 KPI86275.1 - 0.04 13.5 0.3 0.098 12.3 0.3 1.7 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases ExoD PF06055.12 KPI86275.1 - 0.093 12.1 0.4 0.45 9.9 0.2 2.0 1 1 1 2 2 2 0 Exopolysaccharide synthesis, ExoD dCMP_cyt_deam_1 PF00383.23 KPI86275.1 - 0.36 10.7 9.7 0.35 10.8 4.0 3.2 2 2 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region Methyltr_RsmB-F PF01189.17 KPI86276.1 - 1.6e-19 70.4 0.0 2.9e-09 36.9 0.0 3.3 3 0 0 3 3 3 3 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KPI86276.1 - 0.034 14.3 0.0 0.77 9.8 0.0 2.3 2 0 0 2 2 2 0 FtsJ-like methyltransferase PPR_2 PF13041.6 KPI86277.1 - 0.00024 21.2 0.0 0.059 13.6 0.0 3.3 3 0 0 3 3 3 1 PPR repeat family PPR_3 PF13812.6 KPI86277.1 - 0.014 15.4 0.0 3.5 7.8 0.0 3.4 2 1 1 3 3 3 0 Pentatricopeptide repeat domain TPR_19 PF14559.6 KPI86277.1 - 0.034 14.7 0.2 0.16 12.5 0.2 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat NinF PF05810.12 KPI86277.1 - 0.12 12.3 0.1 6.4 6.7 0.1 2.5 2 0 0 2 2 2 0 NinF protein Pkinase PF00069.25 KPI86278.1 - 1.9e-72 243.8 0.0 2.6e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86278.1 - 1.9e-39 135.5 0.0 2.9e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI86278.1 - 7.7e-06 25.4 0.0 2e-05 24.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 KPI86278.1 - 7.7e-05 22.4 0.1 0.00033 20.3 0.1 1.8 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 KPI86278.1 - 0.00011 21.6 0.0 0.00023 20.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI86278.1 - 0.00063 18.8 0.1 0.001 18.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI86278.1 - 0.0045 16.9 0.1 0.12 12.3 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Gpi1 PF05024.15 KPI86279.1 - 4.3e-38 131.3 2.4 1.5e-37 129.5 2.4 1.9 1 1 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) BROMI PF14961.6 KPI86279.1 - 0.3 8.5 1.5 0.41 8.0 1.5 1.1 1 0 0 1 1 1 0 Broad-minded protein EAP30 PF04157.16 KPI86280.1 - 0.0015 17.8 0.3 0.0074 15.6 0.1 2.2 2 0 0 2 2 2 1 EAP30/Vps36 family ArnB_C PF18677.1 KPI86280.1 - 0.11 12.6 1.7 1.5 9.0 0.1 3.2 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain adh_short PF00106.25 KPI86284.1 - 8.7e-06 25.3 0.0 0.0007 19.1 0.1 2.9 2 1 0 2 2 2 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 KPI86284.1 - 0.0097 15.3 0.0 0.036 13.5 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 KPI86284.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 KPI86284.1 - 0.043 13.4 0.1 0.43 10.1 0.0 2.4 2 1 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase ATP-synt_I PF03899.15 KPI86284.1 - 4.3 7.8 7.1 1.1 9.7 1.9 2.5 3 0 0 3 3 3 0 ATP synthase I chain AAA_12 PF13087.6 KPI86285.1 - 1.7e-32 112.6 0.0 2.8e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KPI86285.1 - 3.3e-15 56.6 1.7 8.2e-13 48.7 1.7 2.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI86285.1 - 2.6e-07 30.6 0.2 0.0018 18.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KPI86285.1 - 7.9e-06 26.3 0.2 0.29 11.5 0.0 3.2 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 KPI86285.1 - 0.0017 18.2 1.0 2.8 7.6 0.1 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 KPI86285.1 - 0.01 15.1 0.1 0.036 13.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 KPI86285.1 - 0.012 15.8 0.2 1.3 9.2 0.0 3.1 2 0 0 2 2 2 0 AAA domain zf-C2H2_10 PF16588.5 KPI86285.1 - 0.019 14.7 4.0 0.039 13.7 4.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger PhoH PF02562.16 KPI86285.1 - 0.022 14.2 0.0 0.19 11.1 0.0 2.4 3 0 0 3 3 3 0 PhoH-like protein AAA_33 PF13671.6 KPI86285.1 - 0.15 12.2 6.6 5.5 7.1 0.0 4.0 5 0 0 5 5 5 0 AAA domain AAA_16 PF13191.6 KPI86285.1 - 0.25 11.7 1.8 1.4 9.3 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain DUF2052 PF09747.9 KPI86285.1 - 4.7 7.3 10.0 0.26 11.4 3.9 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) TNFR_16_TM PF18422.1 KPI86286.1 - 0.16 12.0 0.9 0.26 11.3 0.9 1.3 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TANGO2 PF05742.12 KPI86287.1 - 6.1e-21 75.6 0.0 2.8e-14 53.8 0.0 2.8 2 1 0 2 2 2 2 Transport and Golgi organisation 2 Limkain-b1 PF11608.8 KPI86287.1 - 0.14 12.2 0.1 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 Limkain b1 DUF4586 PF15239.6 KPI86288.1 - 2e-34 120.2 7.5 2.5e-34 119.9 7.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) VTC PF09359.10 KPI86289.1 - 8e-79 264.9 0.1 1.2e-78 264.3 0.1 1.3 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 KPI86289.1 - 1.3e-05 25.6 1.1 1.3e-05 25.6 1.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) AAA_2 PF07724.14 KPI86290.1 - 3e-41 141.4 1.4 3.3e-33 115.2 0.1 2.7 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 KPI86290.1 - 1.9e-12 47.8 3.2 9e-05 22.9 0.0 3.3 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KPI86290.1 - 1.7e-07 31.2 0.2 1.7e-07 31.2 0.2 2.3 3 0 0 3 3 3 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 KPI86290.1 - 3.6e-06 27.0 1.2 8.2e-05 22.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) MCM PF00493.23 KPI86290.1 - 0.00011 21.3 0.0 0.013 14.7 0.0 2.5 2 0 0 2 2 2 1 MCM P-loop domain AAA_22 PF13401.6 KPI86290.1 - 0.00014 22.2 0.0 0.0039 17.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KPI86290.1 - 0.00061 20.2 2.7 0.0068 16.8 1.2 2.8 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 KPI86290.1 - 0.0047 16.3 0.1 0.068 12.5 0.0 2.9 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 KPI86290.1 - 0.0091 15.8 0.0 0.36 10.6 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 KPI86290.1 - 0.0094 16.3 0.7 0.16 12.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 KPI86290.1 - 0.014 15.1 0.1 0.22 11.2 0.0 2.8 3 1 1 4 4 4 0 Sigma-54 interaction domain AAA_18 PF13238.6 KPI86290.1 - 0.022 15.3 0.0 0.24 11.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KPI86290.1 - 0.055 13.2 0.1 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KPI86290.1 - 0.058 12.8 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 KPI86290.1 - 0.061 12.8 0.0 0.3 10.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 KPI86290.1 - 0.065 13.0 0.4 8.4 6.1 0.0 2.6 3 0 0 3 3 3 0 DEAD/DEAH box helicase MTS PF05175.14 KPI86290.1 - 0.076 12.6 0.1 0.91 9.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain ATP-synt_ab PF00006.25 KPI86290.1 - 0.087 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain UCH PF00443.29 KPI86291.1 - 4e-36 124.8 0.0 6.6e-36 124.1 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MCM PF00493.23 KPI86292.1 - 9e-91 302.9 0.0 5.4e-80 267.7 0.0 2.5 2 0 0 2 2 2 2 MCM P-loop domain MCM_OB PF17207.3 KPI86292.1 - 2.9e-35 120.9 0.5 5.6e-35 119.9 0.5 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KPI86292.1 - 6.5e-23 81.0 3.1 1.3e-22 80.0 3.1 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 KPI86292.1 - 4.3e-09 36.5 0.0 9.1e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM_N PF14551.6 KPI86292.1 - 2e-08 34.7 0.0 6.4e-08 33.1 0.0 1.9 2 0 0 2 2 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KPI86292.1 - 1.7e-07 30.8 0.0 2.3e-05 23.9 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KPI86292.1 - 0.0024 17.6 0.1 0.18 11.5 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 KPI86292.1 - 0.0028 18.0 0.7 0.06 13.7 0.1 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_3 PF07726.11 KPI86292.1 - 0.0033 17.3 0.0 0.0082 16.0 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TcA_TcB_BD PF18276.1 KPI86292.1 - 0.042 12.9 0.1 0.072 12.2 0.1 1.2 1 0 0 1 1 1 0 Tc toxin complex TcA C-terminal TcB-binding domain Med31 PF05669.12 KPI86292.1 - 0.097 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 SOH1 PknG_rubred PF16919.5 KPI86292.1 - 0.5 10.5 3.1 0.78 9.9 0.9 2.5 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain G10 PF01125.17 KPI86293.1 - 5e-49 165.8 1.3 4.4e-48 162.8 1.3 2.0 1 1 0 1 1 1 1 G10 protein SMBP PF16785.5 KPI86293.1 - 0.12 12.6 1.5 0.21 11.8 1.5 1.4 1 0 0 1 1 1 0 Small metal-binding protein MFS_1 PF07690.16 KPI86294.1 - 1.9e-24 86.3 33.3 6.7e-16 58.1 13.5 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily COX7C PF02935.16 KPI86294.1 - 2.8 8.3 6.0 1 9.7 2.0 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc CAV_VP3 PF04771.12 KPI86295.1 - 0.047 13.8 2.4 0.16 12.1 2.4 1.9 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein Kinesin PF00225.23 KPI86296.1 - 1.7e-31 109.4 0.0 4.4e-11 42.3 0.0 4.1 3 1 0 3 3 3 3 Kinesin motor domain Microtub_bd PF16796.5 KPI86296.1 - 0.021 14.8 0.0 0.11 12.5 0.0 2.1 1 1 0 1 1 1 0 Microtubule binding Sugarporin_N PF11471.8 KPI86296.1 - 0.14 12.1 3.1 0.82 9.7 3.1 2.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Pkinase PF00069.25 KPI86298.1 - 5.1e-47 160.4 0.0 8.9e-46 156.4 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86298.1 - 5.9e-21 74.9 0.1 1.2e-16 60.8 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI86298.1 - 5.3e-05 22.7 0.0 0.00012 21.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KPI86298.1 - 0.0021 18.0 0.0 0.0021 18.0 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI86298.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI86298.1 - 0.041 12.8 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KPI86298.1 - 0.046 12.5 0.0 0.078 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase YAF2_RYBP PF17219.3 KPI86299.1 - 0.49 10.0 2.2 1.3 8.7 2.2 1.7 1 0 0 1 1 1 0 Yaf2/RYBP C-terminal binding motif OppC_N PF12911.7 KPI86299.1 - 2.3 8.3 6.9 7 6.7 0.2 2.7 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C CHASE PF03924.13 KPI86300.1 - 0.055 13.4 0.0 0.47 10.4 0.0 2.3 2 0 0 2 2 2 0 CHASE domain zf-RING_2 PF13639.6 KPI86302.1 - 7.4e-06 26.2 11.4 7.4e-06 26.2 11.4 3.6 4 0 0 4 4 4 1 Ring finger domain zf-rbx1 PF12678.7 KPI86302.1 - 1.5e-05 25.2 4.1 1.5e-05 25.2 4.1 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KPI86302.1 - 0.0051 16.8 3.0 0.0051 16.8 3.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KPI86302.1 - 0.0092 15.8 10.9 0.0092 15.8 10.9 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI86302.1 - 0.011 15.7 8.0 0.011 15.7 8.0 3.2 4 0 0 4 4 4 0 zinc-RING finger domain zf-RING_11 PF17123.5 KPI86302.1 - 0.062 13.1 6.0 0.063 13.0 1.2 2.7 2 0 0 2 2 2 0 RING-like zinc finger Rad50_zn_hook PF04423.14 KPI86302.1 - 8.1 6.4 6.7 0.26 11.2 0.3 1.8 2 0 0 2 2 2 0 Rad50 zinc hook motif FAD_binding_7 PF03441.14 KPI86303.1 - 2.6e-33 115.2 0.3 4.8e-33 114.4 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KPI86303.1 - 2.1e-19 70.1 1.6 6.6e-19 68.5 0.0 2.5 2 1 1 3 3 3 1 DNA photolyase Ank_4 PF13637.6 KPI86304.1 - 8.7e-07 29.4 0.0 2.4e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI86304.1 - 0.00069 20.2 0.0 0.002 18.7 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI86304.1 - 0.0016 18.7 0.0 0.004 17.4 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI86304.1 - 0.017 15.6 0.0 0.051 14.2 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat Ank PF00023.30 KPI86304.1 - 0.16 12.4 0.0 0.58 10.7 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeat SBP_bac_11 PF13531.6 KPI86307.1 - 0.037 13.8 0.0 1.3 8.7 0.0 2.5 2 1 0 2 2 2 0 Bacterial extracellular solute-binding protein Vps16_C PF04840.12 KPI86308.1 - 1.9e-16 60.0 0.1 9.3e-09 34.8 0.0 2.9 2 1 0 2 2 2 2 Vps16, C-terminal region Vps16_N PF04841.13 KPI86308.1 - 1.8e-07 30.3 0.0 0.0021 16.9 0.0 4.2 4 0 0 4 4 4 3 Vps16, N-terminal region Choline_kinase PF01633.20 KPI86309.1 - 2.1e-21 76.5 0.1 7.5e-21 74.7 0.1 1.8 2 1 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 KPI86309.1 - 3.6e-10 40.2 0.0 1.3e-09 38.3 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 KPI86309.1 - 0.0015 17.9 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain EcKinase PF02958.20 KPI86309.1 - 0.029 13.7 0.0 0.049 12.9 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase AlbA_2 PF04326.14 KPI86310.1 - 1e-05 25.9 0.0 2.6e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Putative DNA-binding domain Snf7 PF03357.21 KPI86311.1 - 3.5e-34 117.9 36.1 6.8e-34 117.0 36.0 1.5 1 1 1 2 2 2 1 Snf7 CBF PF03914.17 KPI86313.1 - 5.5e-32 111.1 2.7 5.5e-32 111.1 2.7 2.5 2 1 0 2 2 2 1 CBF/Mak21 family DUF2773 PF10971.8 KPI86313.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2773) BUD22 PF09073.10 KPI86313.1 - 1 8.6 15.9 1.7 7.9 15.9 1.2 1 0 0 1 1 1 0 BUD22 PCI PF01399.27 KPI86314.1 - 3.4e-18 66.1 0.1 6.9e-18 65.1 0.1 1.5 1 0 0 1 1 1 1 PCI domain Rpn3_C PF08375.11 KPI86314.1 - 1.3e-15 57.6 1.2 1.3e-15 57.6 1.2 1.9 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal TPR_2 PF07719.17 KPI86314.1 - 0.069 13.3 0.8 0.22 11.7 0.8 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat GIY-YIG PF01541.24 KPI86314.1 - 0.16 12.2 0.2 5.3 7.4 0.1 2.4 2 0 0 2 2 2 0 GIY-YIG catalytic domain cNMP_binding PF00027.29 KPI86315.1 - 2.8e-12 46.5 0.0 0.0042 17.1 0.0 5.2 6 0 0 6 6 6 3 Cyclic nucleotide-binding domain COG2 PF06148.11 KPI86316.1 - 2.2 8.3 4.3 21 5.2 0.0 2.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF543 PF04418.12 KPI86320.1 - 3.5e-22 78.2 0.0 4.1e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) TctA PF01970.16 KPI86320.1 - 0.012 14.4 0.1 0.052 12.3 0.0 1.8 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctA family RNA_pol_L_2 PF13656.6 KPI86322.1 - 9e-23 79.8 0.0 1.2e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KPI86322.1 - 7.4e-06 25.3 0.0 1.4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DAGAT PF03982.13 KPI86323.1 - 1.5e-23 83.2 0.0 2.7e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DAGAT PF03982.13 KPI86324.1 - 3.1e-30 105.1 0.0 5.6e-30 104.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Remorin_N PF03766.13 KPI86325.1 - 0.34 11.0 1.8 0.5 10.4 0.5 2.0 2 0 0 2 2 2 0 Remorin, N-terminal region Aa_trans PF01490.18 KPI86326.1 - 1.1e-59 202.2 31.6 1.4e-59 201.9 31.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI86326.1 - 5.1e-12 45.5 9.2 5.1e-12 45.5 9.2 1.8 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family DUF4231 PF14015.6 KPI86326.1 - 0.0055 17.1 9.1 0.16 12.4 0.5 3.6 3 1 1 4 4 4 2 Protein of unknown function (DUF4231) ZapB PF06005.12 KPI86329.1 - 0.1 13.1 5.9 2.4 8.7 0.4 3.4 3 0 0 3 3 3 0 Cell division protein ZapB Actin PF00022.19 KPI86330.1 - 7.1e-61 206.0 0.0 8.4e-61 205.8 0.0 1.0 1 0 0 1 1 1 1 Actin DUF639 PF04842.12 KPI86331.1 - 0.3 10.5 1.0 0.65 9.4 0.5 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF639) RrnaAD PF00398.20 KPI86332.1 - 1.7e-23 83.0 0.0 1.6e-14 53.7 0.0 2.1 2 0 0 2 2 2 2 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 KPI86332.1 - 0.0068 17.1 0.0 0.022 15.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain SUIM_assoc PF16619.5 KPI86332.1 - 0.019 15.0 0.1 0.045 13.8 0.1 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CBS PF00571.28 KPI86333.1 - 5.4e-15 55.6 2.3 0.0003 21.2 0.1 4.3 4 0 0 4 4 4 4 CBS domain PA28_beta PF02252.18 KPI86334.1 - 1.6e-10 40.8 0.0 2.2e-06 27.4 0.0 2.4 2 0 0 2 2 2 2 Proteasome activator pa28 beta subunit PPE PF00823.19 KPI86334.1 - 0.18 11.9 4.0 0.31 11.1 1.5 2.1 2 0 0 2 2 2 0 PPE family FHA PF00498.26 KPI86335.1 - 4.1e-05 23.8 0.0 0.00018 21.8 0.0 2.1 1 1 0 1 1 1 1 FHA domain SET PF00856.28 KPI86336.1 - 9.5e-12 45.6 0.5 4.6e-06 27.1 0.0 3.5 3 1 0 3 3 3 2 SET domain Exo_endo_phos PF03372.23 KPI86338.1 - 2e-10 40.6 0.0 3.5e-10 39.8 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ATP-synt_D PF01813.17 KPI86339.1 - 7.2e-73 244.6 1.7 7.2e-73 244.6 1.7 1.4 2 0 0 2 2 2 1 ATP synthase subunit D TPR_12 PF13424.6 KPI86340.1 - 1.1e-59 198.6 39.3 2.5e-14 53.3 2.4 8.4 5 3 2 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 KPI86340.1 - 8e-44 146.4 27.4 3.4e-06 26.7 0.2 12.8 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86340.1 - 1e-18 65.9 44.4 0.005 16.9 0.1 12.3 12 1 0 12 12 12 6 Tetratricopeptide repeat TPR_1 PF00515.28 KPI86340.1 - 4.8e-17 61.0 42.8 0.0009 19.0 0.0 12.6 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86340.1 - 1.8e-16 58.9 35.1 0.056 13.7 0.1 12.2 12 1 0 12 12 12 6 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86340.1 - 2.8e-14 52.0 16.8 0.0012 18.7 0.1 8.7 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 KPI86340.1 - 6.2e-09 36.4 30.3 0.0031 18.1 0.1 8.5 7 2 2 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86340.1 - 1e-06 29.1 33.7 9.7 7.3 0.0 11.4 10 2 2 12 12 11 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86340.1 - 3.8e-06 27.3 23.2 0.024 15.1 0.6 7.3 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KPI86340.1 - 0.00014 21.3 18.4 0.00098 18.6 5.3 4.1 2 1 3 5 5 5 3 MalT-like TPR region SET_assoc PF11767.8 KPI86340.1 - 0.024 14.3 0.0 0.073 12.7 0.0 1.8 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated TPR_11 PF13414.6 KPI86340.1 - 0.041 13.6 5.4 14 5.5 0.0 5.1 5 0 0 5 5 5 0 TPR repeat SHNi-TPR PF10516.9 KPI86340.1 - 0.091 12.2 0.5 15 5.2 0.0 3.7 4 0 0 4 4 4 0 SHNi-TPR MIT PF04212.18 KPI86340.1 - 0.54 10.4 7.1 18 5.5 0.1 4.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 KPI86340.1 - 2.7 8.6 16.4 65 4.2 0.2 7.6 8 1 1 9 9 9 0 Tetratricopeptide repeat ANAPC5 PF12862.7 KPI86340.1 - 3.4 7.8 19.3 3.6 7.7 0.3 5.6 3 2 4 7 7 7 0 Anaphase-promoting complex subunit 5 HEAT PF02985.22 KPI86342.1 - 5.9 7.4 8.6 1.6e+02 3.0 0.0 6.0 6 0 0 6 6 6 0 HEAT repeat zf-C3HC4_2 PF13923.6 KPI86343.1 - 0.32 10.9 13.7 0.085 12.7 8.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI86343.1 - 0.89 9.5 11.9 0.51 10.2 7.9 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KPI86343.1 - 0.92 9.6 13.0 0.017 15.1 5.8 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_6 PF14835.6 KPI86343.1 - 1.6 8.7 11.6 0.46 10.4 7.8 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 KPI86343.1 - 2 8.6 12.4 0.026 14.7 4.6 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KPI86343.1 - 2.3 8.1 13.4 0.37 10.7 8.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI86343.1 - 2.6 8.1 13.5 0.47 10.4 8.7 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 KPI86343.1 - 4.5 7.7 18.6 0.095 13.1 8.7 2.9 3 0 0 3 3 3 0 Ring finger domain Glyco_hydro_32C PF08244.12 KPI86344.1 - 1.7e-14 54.1 0.0 6e-14 52.3 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal PAN_4 PF14295.6 KPI86344.1 - 0.00018 21.3 0.7 0.00036 20.4 0.7 1.4 1 0 0 1 1 1 1 PAN domain MRP-L27 PF09809.9 KPI86344.1 - 0.0028 17.5 0.0 0.0093 15.8 0.0 1.9 1 1 1 2 2 2 1 Mitochondrial ribosomal protein L27 Glyco_hydro_32N PF00251.20 KPI86344.1 - 0.1 12.1 0.3 0.17 11.4 0.3 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain MAPEG PF01124.18 KPI86345.1 - 0.078 12.9 0.6 0.23 11.3 0.6 1.8 1 1 0 1 1 1 0 MAPEG family IF-2B PF01008.17 KPI86346.1 - 1.1e-23 83.9 0.9 8e-22 77.7 0.9 2.9 1 1 0 1 1 1 1 Initiation factor 2 subunit family RMMBL PF07521.12 KPI86346.1 - 0.028 14.3 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain PITH PF06201.13 KPI86347.1 - 4.6e-23 82.1 0.0 5.5e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 PITH domain Proteasome PF00227.26 KPI86348.1 - 6e-41 140.0 1.4 7.8e-41 139.7 1.4 1.1 1 0 0 1 1 1 1 Proteasome subunit DAP3 PF10236.9 KPI86349.1 - 4.8e-23 81.8 0.0 8.5e-20 71.1 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 KPI86349.1 - 0.011 16.1 0.0 0.026 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 KPI86349.1 - 0.025 13.6 0.0 0.037 13.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 KPI86349.1 - 0.053 13.3 0.1 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_10 PF12846.7 KPI86349.1 - 0.084 11.8 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_7 PF12775.7 KPI86349.1 - 0.12 11.9 0.0 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 KPI86349.1 - 0.23 11.2 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Metallophos PF00149.28 KPI86351.1 - 0.00025 21.6 0.0 0.00034 21.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Bmt2 PF11968.8 KPI86351.1 - 0.089 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Isochorismatase PF00857.20 KPI86352.1 - 1.6e-13 51.2 0.4 3.3e-13 50.2 0.4 1.5 1 1 0 1 1 1 1 Isochorismatase family Apyrase PF06079.11 KPI86354.1 - 0.018 14.2 0.0 0.051 12.8 0.0 1.6 2 0 0 2 2 2 0 Apyrase ART PF01129.18 KPI86354.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.2 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase TPR_19 PF14559.6 KPI86355.1 - 0.00019 21.8 3.2 1.3 9.6 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86355.1 - 0.00029 21.4 6.9 0.36 11.8 0.1 4.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 KPI86355.1 - 0.001 19.5 0.5 1.3 9.8 0.2 3.8 2 0 0 2 2 2 1 Tetratricopeptide repeat PPR PF01535.20 KPI86355.1 - 0.003 17.7 1.4 0.39 11.1 0.0 3.1 3 0 0 3 3 3 1 PPR repeat TPR_7 PF13176.6 KPI86355.1 - 0.012 15.6 0.2 8.1 6.7 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86355.1 - 0.085 13.1 0.1 6.3 7.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86355.1 - 0.34 11.1 2.0 1.9 8.8 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86355.1 - 0.35 11.2 2.0 11 6.4 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI86355.1 - 0.51 11.0 7.4 0.53 11.0 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DNA_ligase_A_M PF01068.21 KPI86356.1 - 2.1e-44 151.6 0.0 3.1e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KPI86356.1 - 4.2e-19 69.5 0.0 8.2e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 KPI86356.1 - 1.1e-11 45.2 0.0 2.3e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 KPI86356.1 - 8.5e-06 26.1 0.0 0.56 10.7 0.0 3.4 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 KPI86356.1 - 2e-05 24.9 0.0 3.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 RNA ligase BRCT PF00533.26 KPI86356.1 - 8.8e-05 22.8 0.0 0.038 14.4 0.0 3.1 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.19 KPI86356.1 - 0.17 11.7 0.1 0.44 10.3 0.1 1.8 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain Plus-3 PF03126.18 KPI86357.1 - 4.2e-20 72.3 0.0 9.1e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Plus-3 domain zf-C3HC4_3 PF13920.6 KPI86357.1 - 9.5e-07 28.6 16.3 1.5e-06 28.0 16.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 KPI86357.1 - 0.033 14.7 5.9 0.067 13.6 5.9 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 FYVE PF01363.21 KPI86358.1 - 1.8e-08 34.4 5.3 1.8e-08 34.4 5.3 2.4 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 KPI86358.1 - 0.74 10.2 8.6 1.8 8.9 8.4 1.9 1 1 0 1 1 1 0 Ring finger domain C1_1 PF00130.22 KPI86358.1 - 3.4 7.6 12.3 0.69 9.9 8.2 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2HC5 PF06221.13 KPI86358.1 - 3.8 7.6 12.5 56 3.8 12.6 2.9 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type CENP-F_leu_zip PF10473.9 KPI86359.1 - 0.0087 16.1 4.2 0.0087 16.1 4.2 8.5 3 2 3 8 8 8 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Eno-Rase_FAD_bd PF07055.12 KPI86359.1 - 0.017 15.5 0.6 0.017 15.5 0.6 2.7 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain Nsp1_C PF05064.13 KPI86359.1 - 0.025 14.4 10.2 2.2 8.1 0.3 4.1 1 1 2 3 3 3 0 Nsp1-like C-terminal region DinI PF06183.13 KPI86359.1 - 2.8 8.3 7.5 43 4.6 1.4 3.9 3 0 0 3 3 3 0 DinI-like family Pkinase PF00069.25 KPI86360.1 - 5.8e-38 130.8 0.0 2.2e-17 63.3 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86360.1 - 1.1e-16 60.9 0.0 2.1e-08 33.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Ribosomal_60s PF00428.19 KPI86360.1 - 0.043 14.4 0.3 0.043 14.4 0.3 3.1 4 0 0 4 4 4 0 60s Acidic ribosomal protein Antimicrobial10 PF08105.11 KPI86361.1 - 0.21 11.7 1.4 1.5 9.0 0.2 2.6 2 0 0 2 2 2 0 Metchnikowin family LRR_8 PF13855.6 KPI86362.1 - 8.3e-10 38.3 1.8 0.0059 16.3 0.0 4.2 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KPI86362.1 - 2.8e-08 33.9 6.6 0.0029 18.0 0.3 4.5 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI86362.1 - 0.026 14.0 0.1 0.13 11.8 0.0 2.0 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 KPI86362.1 - 3.1 8.1 12.7 59 4.1 0.1 5.8 6 0 0 6 6 6 0 Leucine Rich repeat Glyco_transf_22 PF03901.17 KPI86363.1 - 3.3e-34 118.8 3.4 4.2e-25 88.8 6.9 3.0 2 1 0 2 2 2 2 Alg9-like mannosyltransferase family UCH PF00443.29 KPI86366.1 - 6.3e-25 88.1 0.0 1.1e-23 84.0 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI86366.1 - 5.6e-07 29.4 0.0 0.021 14.4 0.0 3.6 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Siah-Interact_N PF09032.11 KPI86367.1 - 3.5 8.0 7.7 1.7 9.0 3.6 2.7 2 0 0 2 2 2 0 Siah interacting protein, N terminal ELO PF01151.18 KPI86368.1 - 3.7e-34 118.4 2.7 4.7e-34 118.0 2.7 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI86369.1 - 2.7e-75 253.1 17.1 3.3e-75 252.8 17.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DUF192 PF02643.15 KPI86370.1 - 0.0088 16.2 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Ras PF00071.22 KPI86371.1 - 3e-35 121.2 0.0 3.9e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI86371.1 - 5.3e-27 94.4 0.0 7.7e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI86371.1 - 6.7e-09 35.4 0.0 8.7e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI86371.1 - 4.4e-07 29.5 0.0 6e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 KPI86371.1 - 0.0054 16.3 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 KPI86371.1 - 0.014 15.4 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI86371.1 - 0.054 13.4 0.0 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 KPI86371.1 - 0.083 12.6 0.0 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KPI86371.1 - 0.091 13.0 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KPI86371.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MCM PF00493.23 KPI86371.1 - 0.11 11.6 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain NACHT PF05729.12 KPI86371.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 KPI86371.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Ribosomal_L21p PF00829.21 KPI86373.1 - 6.8e-20 71.2 0.1 9.2e-20 70.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein DUF572 PF04502.13 KPI86375.1 - 0.66 9.5 10.1 0.16 11.6 6.8 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF572) ResB PF05140.14 KPI86375.1 - 0.9 8.2 4.2 0.66 8.6 2.6 1.4 1 1 0 1 1 1 0 ResB-like family Kinesin PF00225.23 KPI86376.1 - 6.4e-88 294.9 0.0 1.8e-87 293.4 0.0 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI86376.1 - 1e-18 67.7 0.0 2.3e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF4201 PF13870.6 KPI86377.1 - 1.8e-29 102.8 17.0 1.8e-29 102.8 17.0 3.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4201) Med30 PF11315.8 KPI86377.1 - 0.00055 20.2 1.1 0.00055 20.2 1.1 2.8 2 1 0 2 2 2 1 Mediator complex subunit 30 LURAP PF14854.6 KPI86377.1 - 0.21 11.6 2.0 6.4 6.8 0.0 3.3 3 1 0 3 3 3 0 Leucine rich adaptor protein SlyX PF04102.12 KPI86377.1 - 0.51 11.0 0.0 0.51 11.0 0.0 6.7 5 2 1 6 6 6 0 SlyX Pkinase PF00069.25 KPI86378.1 - 6.7e-43 147.0 0.0 1.6e-23 83.5 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86378.1 - 3.3e-14 52.8 0.0 2.4e-09 36.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KPI86378.1 - 0.00017 21.6 0.4 0.0017 18.3 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KPI86378.1 - 0.26 10.8 0.0 0.39 10.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase SNF2_N PF00176.23 KPI86379.1 - 3.7e-60 203.5 0.0 2.1e-59 201.0 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI86379.1 - 8.1e-19 68.0 0.0 3.6e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI86379.1 - 1.9e-07 31.2 0.0 5e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KPI86379.1 - 3.2e-05 23.8 0.0 0.00019 21.3 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase AChE_tetra PF08674.10 KPI86379.1 - 0.039 13.6 0.1 0.039 13.6 0.1 2.1 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain DUF2518 PF10726.9 KPI86379.1 - 0.31 10.7 0.9 1 9.0 0.0 2.3 3 0 0 3 3 3 0 Protein of function (DUF2518) DUF1935 PF09149.10 KPI86380.1 - 1.3e-40 137.9 0.7 1.5e-40 137.7 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) SIS PF01380.22 KPI86381.1 - 3.3e-05 23.7 0.0 0.00019 21.3 0.0 2.1 2 1 0 2 2 2 1 SIS domain SIS_2 PF13580.6 KPI86381.1 - 0.023 14.7 0.9 0.5 10.4 0.0 2.1 1 1 1 2 2 2 0 SIS domain SDA1 PF05285.12 KPI86383.1 - 0.15 11.4 19.2 1.1 8.6 19.2 2.0 1 1 0 1 1 1 0 SDA1 Nop14 PF04147.12 KPI86383.1 - 2.8 6.0 17.0 4.2 5.4 17.0 1.1 1 0 0 1 1 1 0 Nop14-like family RHS PF03527.14 KPI86385.1 - 0.048 13.4 0.2 0.072 12.9 0.2 1.3 1 0 0 1 1 1 0 RHS protein His_Phos_1 PF00300.22 KPI86388.1 - 1.5e-13 50.9 0.0 1.3e-10 41.3 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 KPI86388.1 - 0.14 11.5 0.0 0.35 10.2 0.0 1.6 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) DSPc PF00782.20 KPI86389.1 - 4.4e-07 29.8 0.0 6.8e-06 25.9 0.1 2.5 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain CHAD PF05235.14 KPI86389.1 - 0.013 15.5 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 CHAD domain Y_phosphatase PF00102.27 KPI86389.1 - 0.023 14.2 0.1 0.037 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ANAPC_CDC26 PF10471.9 KPI86392.1 - 1 10.2 8.4 2.8 8.8 1.3 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Acyltransferase PF01553.21 KPI86395.1 - 0.00049 19.7 0.0 0.00088 18.9 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase IRK_C PF17655.1 KPI86396.1 - 7.6e-06 25.6 0.0 0.079 12.6 0.0 2.3 2 0 0 2 2 2 2 Inward rectifier potassium channel C-terminal domain MAP65_ASE1 PF03999.12 KPI86396.1 - 3.1 6.4 8.6 4.3 5.9 8.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SOG2 PF10428.9 KPI86396.1 - 6.2 5.9 11.8 8.5 5.5 11.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Metallophos PF00149.28 KPI86397.1 - 5.2e-23 82.6 0.3 8.5e-23 81.9 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Herpes_BLRF2 PF05812.12 KPI86397.1 - 0.096 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Mon2_C PF16206.5 KPI86398.1 - 7.2e-09 34.4 0.0 1.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of Mon2 protein FH2 PF02181.23 KPI86399.1 - 1.5 7.8 9.9 0.29 10.2 1.2 2.9 1 1 2 3 3 3 0 Formin Homology 2 Domain TPR_2 PF07719.17 KPI86400.1 - 1.1e-14 53.3 17.4 0.056 13.6 0.0 9.2 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_1 PF00515.28 KPI86400.1 - 1.4e-14 53.2 15.0 0.058 13.2 0.0 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86400.1 - 3.9e-14 51.6 1.9 0.23 11.8 0.0 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86400.1 - 5e-12 45.6 17.9 0.069 14.0 0.8 8.2 5 2 5 10 10 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 KPI86400.1 - 2.6e-10 40.7 13.2 0.051 14.2 0.7 6.5 6 1 0 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86400.1 - 3.2e-10 40.3 15.3 0.014 15.9 0.1 5.7 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86400.1 - 8.3e-09 35.6 8.9 0.76 10.1 0.0 6.5 4 1 3 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 KPI86400.1 - 2.6e-08 33.9 9.6 0.028 14.6 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI86400.1 - 6.1e-06 25.8 3.2 4.1 7.2 0.0 6.6 6 2 1 7 7 7 2 TPR repeat TPR_6 PF13174.6 KPI86400.1 - 0.0014 19.1 5.8 5 8.0 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI86400.1 - 0.003 17.7 10.7 12 6.2 0.1 5.4 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 KPI86400.1 - 0.0038 17.3 1.7 0.53 10.4 0.0 3.4 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 KPI86400.1 - 0.02 15.2 6.4 39 4.9 0.1 7.0 7 1 1 8 8 8 0 Tetratricopeptide repeat DUF5112 PF17139.4 KPI86400.1 - 0.028 13.9 0.7 0.064 12.7 0.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5112) TPR_10 PF13374.6 KPI86400.1 - 3.6 7.6 10.5 60 3.7 1.6 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Plus-3 PF03126.18 KPI86401.1 - 1.8e-13 50.9 0.0 5.2e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 Plus-3 domain zf-C3HC4_3 PF13920.6 KPI86401.1 - 4.4e-10 39.3 11.8 7.1e-10 38.6 11.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI86401.1 - 0.00048 19.9 11.0 0.00096 19.0 11.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF3866 PF12982.7 KPI86401.1 - 0.0086 15.2 0.5 0.014 14.5 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3866) zf-RING_2 PF13639.6 KPI86401.1 - 0.071 13.5 12.3 0.12 12.7 12.3 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 KPI86401.1 - 0.23 11.5 10.1 0.41 10.6 10.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain TFIIA PF03153.13 KPI86401.1 - 0.64 9.9 13.9 1.4 8.8 14.0 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KPI86401.1 - 0.8 9.3 6.3 0.1 12.2 2.3 1.6 2 0 0 2 2 2 0 Spt20 family DSPn PF14671.6 KPI86402.1 - 4.9e-20 72.4 0.0 4.1e-12 46.7 0.0 2.4 2 0 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 KPI86402.1 - 1.2e-07 31.6 0.0 2.4e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI86402.1 - 0.0015 18.1 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KPI86402.1 - 0.21 11.7 0.1 1.4 9.0 0.1 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate EF-hand_13 PF17958.1 KPI86403.1 - 1.8e-20 72.5 0.0 4.4e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KPI86403.1 - 6.5e-18 65.0 1.6 2.4e-15 56.7 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI86403.1 - 2.1e-05 24.1 1.3 0.002 17.9 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KPI86403.1 - 3.1e-05 23.2 0.0 0.0058 16.1 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KPI86403.1 - 0.00018 20.8 0.3 0.00082 18.8 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KPI86403.1 - 0.019 14.8 0.1 0.2 11.5 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain pair Rrn6 PF10214.9 KPI86403.1 - 2.6 6.5 8.0 5.9 5.2 8.0 1.5 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Abhydrolase_1 PF00561.20 KPI86404.1 - 0.00016 21.4 0.0 0.00025 20.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KPI86404.1 - 0.00064 20.4 1.7 0.00064 20.4 1.7 2.0 1 1 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KPI86404.1 - 0.096 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein ACBP PF00887.19 KPI86406.1 - 1e-27 96.2 0.8 1.1e-27 96.0 0.8 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein ACBP PF00887.19 KPI86408.1 - 1.3e-26 92.6 1.3 1.4e-26 92.5 1.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein AvrB_AvrC PF05394.11 KPI86408.1 - 0.0098 15.1 0.3 0.012 14.9 0.3 1.0 1 0 0 1 1 1 1 Avirulence protein ACBP PF00887.19 KPI86409.1 - 8.1e-23 80.4 6.4 2.1e-12 47.1 0.0 2.8 3 0 0 3 3 3 2 Acyl CoA binding protein Cation_ATPase_C PF00689.21 KPI86410.1 - 1.2e-39 135.9 3.6 2.9e-39 134.6 3.6 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KPI86410.1 - 1.1e-31 109.8 1.9 1.1e-31 109.8 1.9 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 KPI86410.1 - 5.1e-26 90.6 0.1 1.4e-25 89.1 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KPI86410.1 - 2.9e-16 60.4 3.7 3.7e-14 53.5 3.2 3.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KPI86410.1 - 2.2e-12 46.4 0.0 5.2e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KPI86410.1 - 0.00016 21.5 0.8 0.00044 20.1 0.6 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ATP_Ca_trans_C PF12424.8 KPI86410.1 - 0.028 14.9 0.4 0.066 13.7 0.4 1.7 1 0 0 1 1 1 0 Plasma membrane calcium transporter ATPase C terminal HAD PF12710.7 KPI86410.1 - 0.19 12.1 0.3 0.74 10.2 0.2 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Metallophos PF00149.28 KPI86412.1 - 1.3e-06 29.1 0.0 0.00048 20.7 0.0 2.6 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase ELF PF03317.13 KPI86414.1 - 0.15 12.1 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 ELF protein AAA PF00004.29 KPI86415.1 - 1.2e-09 38.7 0.0 7.1e-09 36.2 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI86415.1 - 1.9e-06 28.2 0.0 4.3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI86415.1 - 2.4e-05 24.2 0.1 6.2e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KPI86415.1 - 4.1e-05 23.6 0.0 0.00029 20.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI86415.1 - 6.9e-05 23.3 0.0 0.00032 21.1 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 KPI86415.1 - 0.00015 21.7 0.0 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_28 PF13521.6 KPI86415.1 - 0.00017 21.9 0.1 0.0006 20.1 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KPI86415.1 - 0.0004 20.7 0.0 0.0012 19.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI86415.1 - 0.00041 20.9 0.0 0.0011 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KPI86415.1 - 0.0012 18.7 0.1 0.0022 17.8 0.1 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KPI86415.1 - 0.0012 19.0 1.1 0.0018 18.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 KPI86415.1 - 0.0032 17.4 0.0 0.0061 16.5 0.0 1.4 1 0 0 1 1 1 1 NTPase RsgA_GTPase PF03193.16 KPI86415.1 - 0.0039 17.1 0.0 0.008 16.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 KPI86415.1 - 0.0066 16.1 0.0 0.018 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KPI86415.1 - 0.028 14.8 0.0 0.076 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KPI86415.1 - 0.058 13.4 0.0 0.16 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_assoc_2 PF16193.5 KPI86415.1 - 0.068 13.5 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain IstB_IS21 PF01695.17 KPI86415.1 - 0.083 12.6 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 KPI86415.1 - 0.095 12.6 0.0 0.46 10.4 0.0 2.2 3 0 0 3 3 1 0 NACHT domain TsaE PF02367.17 KPI86415.1 - 0.096 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KPI86415.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region dNK PF01712.19 KPI86415.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase ABC_tran PF00005.27 KPI86415.1 - 0.17 12.4 0.0 0.52 10.8 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Bclx_interact PF08945.10 KPI86416.1 - 0.036 13.8 0.1 0.13 12.1 0.1 2.0 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain Xlink PF00193.17 KPI86416.1 - 7.6 7.0 8.4 1.2 9.5 3.4 2.3 2 0 0 2 2 2 0 Extracellular link domain Ax_dynein_light PF10211.9 KPI86420.1 - 6.4e-79 264.3 7.7 7.8e-79 264.0 7.7 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain APG6_N PF17675.1 KPI86420.1 - 0.00059 20.4 9.7 0.00059 20.4 9.7 1.9 2 0 0 2 2 2 1 Apg6 coiled-coil region FadA PF09403.10 KPI86420.1 - 0.002 18.6 6.9 0.0045 17.4 6.9 1.6 1 0 0 1 1 1 1 Adhesion protein FadA Mei5 PF10376.9 KPI86420.1 - 0.0022 17.9 3.2 0.0032 17.4 3.2 1.3 1 0 0 1 1 1 1 Double-strand recombination repair protein bZIP_1 PF00170.21 KPI86420.1 - 0.021 14.9 3.9 0.021 14.9 3.9 2.3 2 0 0 2 2 2 0 bZIP transcription factor FapA PF03961.13 KPI86420.1 - 0.023 13.3 2.6 0.03 12.9 2.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Jnk-SapK_ap_N PF09744.9 KPI86420.1 - 0.11 12.7 13.0 0.082 13.1 8.6 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Spc24 PF08286.11 KPI86420.1 - 0.12 12.7 6.8 0.13 12.5 5.2 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 End3 PF12761.7 KPI86420.1 - 0.12 12.6 7.2 0.055 13.6 5.0 1.6 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 HAUS-augmin3 PF14932.6 KPI86420.1 - 0.13 11.9 7.9 0.065 12.8 5.7 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Prefoldin PF02996.17 KPI86420.1 - 0.19 11.7 7.2 1.6 8.7 0.7 2.5 1 1 1 2 2 2 0 Prefoldin subunit CENP-H PF05837.12 KPI86420.1 - 0.64 10.5 6.8 1.7 9.1 6.8 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4337 PF14235.6 KPI86420.1 - 1.4 9.0 4.0 2.6 8.1 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF5320 PF17253.2 KPI86420.1 - 2 9.6 4.7 3.2 8.9 1.4 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DivIC PF04977.15 KPI86420.1 - 2.4 8.0 7.1 2.3 8.0 4.2 2.4 2 1 0 2 2 2 0 Septum formation initiator bZIP_2 PF07716.15 KPI86420.1 - 9.7 6.4 19.0 1 9.5 5.1 3.2 3 0 0 3 3 3 0 Basic region leucine zipper Syja_N PF02383.18 KPI86422.1 - 1.5e-55 188.8 0.0 2.4e-55 188.1 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain DUF547 PF04784.14 KPI86422.1 - 0.024 14.7 0.0 0.074 13.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF547 PTS_2-RNA PF01885.16 KPI86423.1 - 1.5e-53 181.5 0.0 2.3e-53 180.9 0.0 1.3 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family RNase_T PF00929.24 KPI86423.1 - 1.5e-22 80.9 0.0 2.4e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Malic_M PF03949.15 KPI86427.1 - 1.1e-85 287.0 0.2 2.2e-85 286.1 0.1 1.5 2 0 0 2 2 2 1 Malic enzyme, NAD binding domain malic PF00390.19 KPI86427.1 - 2.4e-70 236.0 0.0 4e-70 235.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DUF1515 PF07439.11 KPI86427.1 - 0.057 13.4 0.4 0.54 10.3 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) Malic_M PF03949.15 KPI86428.1 - 2.2e-85 286.0 0.2 3.1e-85 285.6 0.2 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KPI86428.1 - 1.6e-66 223.6 0.1 3.3e-66 222.6 0.0 1.5 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain SNF2_N PF00176.23 KPI86429.1 - 2.2e-56 191.1 0.0 3.6e-56 190.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI86429.1 - 4.9e-16 59.1 0.0 1.7e-15 57.3 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI86429.1 - 1.4e-09 38.1 0.0 2.7e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KPI86429.1 - 3.1e-07 30.3 0.0 6.5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Rad54_N PF08658.10 KPI86429.1 - 0.094 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Rad54 N terminal HDA2-3 PF11496.8 KPI86429.1 - 0.17 11.0 0.0 1.9 7.6 0.0 2.4 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 HAD_SAK_2 PF18143.1 KPI86430.1 - 1.1e-31 110.1 0.1 3e-31 108.6 0.0 1.7 2 0 0 2 2 2 1 HAD domain in Swiss Army Knife RNA repair proteins CENP-F_leu_zip PF10473.9 KPI86430.1 - 0.00012 22.2 1.7 0.00012 22.2 1.7 1.6 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5129 PF17173.4 KPI86430.1 - 0.00081 18.6 2.4 0.0012 18.1 2.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5129) HAUS5 PF14817.6 KPI86430.1 - 0.0028 16.5 1.6 0.0037 16.1 1.6 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Spc24 PF08286.11 KPI86430.1 - 0.033 14.4 1.8 0.055 13.7 1.8 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Takusan PF04822.13 KPI86430.1 - 0.036 13.9 2.5 0.095 12.6 0.1 2.4 2 0 0 2 2 2 0 Takusan Sipho_Gp157 PF05565.11 KPI86430.1 - 0.07 13.1 5.0 0.11 12.5 5.0 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 GAS PF13851.6 KPI86430.1 - 0.099 12.0 6.3 0.16 11.3 6.2 1.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding SKA2 PF16740.5 KPI86430.1 - 0.12 12.2 4.4 0.41 10.4 3.7 2.3 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DivIC PF04977.15 KPI86430.1 - 0.13 12.0 3.8 0.41 10.4 3.8 1.9 1 0 0 1 1 1 0 Septum formation initiator Cnn_1N PF07989.11 KPI86430.1 - 0.14 12.3 5.0 0.11 12.6 1.9 2.1 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 OmpH PF03938.14 KPI86430.1 - 0.16 12.3 6.9 0.28 11.5 6.9 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ABC_tran_CTD PF16326.5 KPI86430.1 - 0.21 11.9 7.3 0.6 10.4 7.3 1.9 1 0 0 1 1 1 0 ABC transporter C-terminal domain CENP-H PF05837.12 KPI86430.1 - 0.31 11.5 6.3 0.29 11.5 5.2 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.12 KPI86430.1 - 0.37 11.3 7.9 0.89 10.0 7.9 1.7 1 1 0 1 1 1 0 Cell division protein ZapB TMF_TATA_bd PF12325.8 KPI86430.1 - 0.8 9.9 8.1 1.5 9.0 7.8 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Atg14 PF10186.9 KPI86430.1 - 0.84 8.7 3.2 1.1 8.2 3.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 KPI86430.1 - 0.89 9.8 4.2 0.37 11.0 0.4 2.3 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II APG6_N PF17675.1 KPI86430.1 - 1.1 9.8 11.7 0.62 10.6 9.3 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region SRP54 PF00448.22 KPI86432.1 - 1.9e-73 246.3 0.9 3.3e-73 245.5 0.9 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 KPI86432.1 - 6.7e-24 84.4 0.1 6.7e-24 84.4 0.1 4.4 5 1 0 5 5 3 1 Signal peptide binding domain SRP54_N PF02881.19 KPI86432.1 - 1.7e-13 50.6 4.1 2e-13 50.3 2.2 2.2 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 KPI86432.1 - 1.7e-07 31.0 0.6 1.1e-06 28.4 0.3 2.3 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 KPI86432.1 - 0.00011 22.3 0.0 0.00024 21.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KPI86432.1 - 0.00031 21.2 0.1 0.0011 19.5 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI86432.1 - 0.00059 19.6 0.1 0.0013 18.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 KPI86432.1 - 0.00081 18.5 0.1 0.0034 16.4 0.0 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 KPI86432.1 - 0.0045 17.0 0.0 0.019 15.0 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 KPI86432.1 - 0.0071 16.6 0.3 0.041 14.2 0.0 2.5 4 0 0 4 4 2 1 AAA domain CLP1_P PF16575.5 KPI86432.1 - 0.011 15.5 0.4 1.4 8.7 0.0 2.6 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRPRB PF09439.10 KPI86432.1 - 0.012 15.0 0.7 2.8 7.3 0.7 2.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KPI86432.1 - 0.012 16.0 0.2 0.035 14.5 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 KPI86432.1 - 0.013 15.4 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase ATP_bind_1 PF03029.17 KPI86432.1 - 0.025 14.4 0.2 0.1 12.4 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Methyltransf_24 PF13578.6 KPI86432.1 - 0.027 15.5 0.0 0.3 12.1 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain AAA_31 PF13614.6 KPI86432.1 - 0.038 13.9 0.2 0.37 10.7 0.2 2.3 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 KPI86432.1 - 0.042 13.8 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 KPI86432.1 - 0.045 13.0 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 KPI86432.1 - 0.065 12.9 0.2 0.16 11.7 0.1 1.8 2 0 0 2 2 1 0 AAA domain DRE2_N PF16803.5 KPI86432.1 - 0.069 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus AAA_7 PF12775.7 KPI86432.1 - 0.077 12.5 0.0 0.24 10.9 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 KPI86432.1 - 0.084 13.0 0.8 0.67 10.1 0.8 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase 2Fe-2S_thioredx PF01257.19 KPI86432.1 - 0.088 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin DUF4788 PF16032.5 KPI86432.1 - 0.089 11.7 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4788) AAA_19 PF13245.6 KPI86432.1 - 0.097 13.0 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain SWI2_SNF2 PF18766.1 KPI86432.1 - 0.11 12.2 0.5 1.6 8.4 0.0 2.3 1 1 1 2 2 2 0 SWI2/SNF2 ATPase Dynamin_N PF00350.23 KPI86432.1 - 0.15 12.1 1.3 0.22 11.6 0.0 1.9 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.6 KPI86432.1 - 0.17 12.4 0.0 0.41 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2209 PF09974.9 KPI86432.1 - 0.23 11.8 2.0 0.53 10.6 0.3 2.4 3 0 0 3 3 2 0 Uncharacterized protein conserved in archaea (DUF2209) NTPase_1 PF03266.15 KPI86432.1 - 0.28 11.1 5.1 2.6 7.9 0.1 2.7 2 1 1 3 3 2 0 NTPase ArsA_ATPase PF02374.15 KPI86432.1 - 1.9 7.6 6.0 6.9 5.8 0.1 3.5 2 1 2 4 4 4 0 Anion-transporting ATPase zf-Tim10_DDP PF02953.15 KPI86433.1 - 8.2e-05 22.2 2.8 0.00012 21.7 2.8 1.4 1 1 0 1 1 1 1 Tim10/DDP family zinc finger DUF523 PF04463.12 KPI86434.1 - 2.5e-16 60.0 0.0 9e-16 58.2 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF523) DUF4731 PF15875.5 KPI86436.1 - 0.049 13.8 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4731) Sugar_tr PF00083.24 KPI86437.1 - 4.8e-121 404.8 30.2 5.5e-121 404.6 30.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KPI86437.1 - 2.8e-30 105.4 33.3 2.8e-30 105.4 33.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KPI86437.1 - 0.0032 16.0 4.1 0.0032 16.0 4.1 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cation_ATPase_C PF00689.21 KPI86437.1 - 0.42 10.3 16.7 27 4.4 14.4 3.8 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus Pkinase PF00069.25 KPI86438.1 - 2e-39 135.6 0.0 5.2e-39 134.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86438.1 - 8.2e-15 54.8 0.0 2.9e-14 53.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI86438.1 - 0.17 10.6 0.0 0.34 9.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase NUMOD1 PF07453.13 KPI86438.1 - 0.22 11.8 0.1 50 4.3 0.0 3.2 3 0 0 3 3 3 0 NUMOD1 domain Ferritin PF00210.24 KPI86439.1 - 0.026 14.5 0.3 0.065 13.2 0.3 1.6 1 0 0 1 1 1 0 Ferritin-like domain EF-hand_7 PF13499.6 KPI86440.1 - 1.3e-11 44.8 0.2 6.3e-08 33.0 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI86440.1 - 1.3e-09 36.9 0.1 0.0028 17.1 0.3 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KPI86440.1 - 7.8e-09 35.3 0.2 2.2e-06 27.4 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI86440.1 - 1.6e-08 33.8 0.2 0.078 12.9 0.2 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KPI86440.1 - 5.6e-07 28.8 0.1 0.017 14.6 0.1 2.5 2 0 0 2 2 2 2 EF hand UPRTase PF14681.6 KPI86441.1 - 2.9e-71 239.2 0.0 3.5e-71 238.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KPI86441.1 - 8.9e-06 25.3 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPF0020 PF01170.18 KPI86441.1 - 0.18 11.5 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 SET PF00856.28 KPI86442.1 - 9.4e-15 55.4 0.0 3.2e-14 53.6 0.0 2.0 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 KPI86442.1 - 2.7e-09 36.4 11.6 0.00046 20.1 0.2 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86442.1 - 3.8e-05 23.9 7.7 0.18 12.1 0.7 4.5 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86442.1 - 0.00018 21.5 4.4 0.093 13.0 0.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI86442.1 - 0.00026 20.7 13.5 0.0091 15.8 0.5 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86442.1 - 0.0011 19.6 3.7 0.24 12.3 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KPI86442.1 - 0.01 15.6 0.5 2.4 8.2 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86442.1 - 0.032 14.3 3.0 7.8 6.8 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_M41 PF01434.18 KPI86443.1 - 4.9e-42 143.9 0.0 8e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KPI86443.1 - 4.7e-39 133.8 0.0 8.5e-39 133.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI86443.1 - 6e-11 42.0 0.1 1.5e-10 40.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 KPI86443.1 - 0.00032 20.8 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KPI86443.1 - 0.00042 20.7 0.0 0.14 12.5 0.1 2.8 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KPI86443.1 - 0.00047 19.9 0.0 0.0014 18.4 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 KPI86443.1 - 0.0029 16.9 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 KPI86443.1 - 0.011 16.1 0.0 0.3 11.3 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KPI86443.1 - 0.012 15.2 0.4 5.2 6.6 0.0 3.0 2 1 0 3 3 3 0 AAA domain AAA_5 PF07728.14 KPI86443.1 - 0.023 14.7 0.5 0.2 11.7 0.2 2.7 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KPI86443.1 - 0.029 14.4 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KPI86443.1 - 0.061 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KPI86443.1 - 0.069 12.5 0.1 0.18 11.1 0.1 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Lipase_3 PF01764.25 KPI86444.1 - 1.1e-07 31.9 0.1 2.5e-07 30.7 0.1 1.6 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KPI86444.1 - 0.0026 17.1 0.1 0.0052 16.1 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI86444.1 - 0.0056 17.3 0.2 0.0056 17.3 0.2 3.0 3 0 0 3 3 3 1 Alpha/beta hydrolase family DUF2974 PF11187.8 KPI86444.1 - 0.019 14.6 0.3 0.05 13.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 KPI86444.1 - 0.03 14.0 0.1 0.064 13.0 0.1 1.5 1 0 0 1 1 1 0 PGAP1-like protein DLH PF01738.18 KPI86444.1 - 0.038 13.5 0.0 0.062 12.8 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 KPI86444.1 - 0.039 13.7 0.1 0.082 12.7 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Oxidored_q3 PF00499.20 KPI86444.1 - 0.076 12.7 0.0 0.076 12.7 0.0 4.0 4 1 1 5 5 5 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 AXE1 PF05448.12 KPI86444.1 - 0.16 10.6 0.0 0.28 9.8 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Acyltransferase PF01553.21 KPI86445.1 - 3.6e-17 62.3 0.0 7.2e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Pirin PF02678.16 KPI86446.1 - 1.9e-18 66.4 0.5 9.7e-18 64.1 0.5 2.0 1 1 0 1 1 1 1 Pirin Pirin_C PF05726.13 KPI86446.1 - 3.8e-18 65.8 0.0 6.5e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain SBDS PF01172.18 KPI86448.1 - 9e-27 93.0 0.4 1.8e-26 92.1 0.4 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 KPI86448.1 - 2.4e-25 88.8 0.0 5.3e-25 87.7 0.0 1.6 2 0 0 2 2 2 1 SBDS protein C-terminal domain CH_2 PF06294.11 KPI86449.1 - 4.5e-30 103.6 0.0 7.4e-30 102.9 0.0 1.3 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 KPI86449.1 - 1.3e-18 66.5 0.0 2.2e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain DMRT-like PF15791.5 KPI86449.1 - 0.025 15.0 0.6 0.04 14.3 0.6 1.3 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 TMF_DNA_bd PF12329.8 KPI86449.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 KPI86449.1 - 0.57 10.8 5.2 1.8 9.3 0.1 2.8 3 0 0 3 3 3 0 SlyX Dus PF01207.17 KPI86451.1 - 1.5e-56 191.8 0.0 2.1e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 KPI86451.1 - 0.036 13.5 0.0 0.077 12.4 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein BMC PF00936.19 KPI86451.1 - 0.11 12.5 0.9 0.23 11.5 0.0 2.0 2 0 0 2 2 2 0 BMC domain DUF167 PF02594.16 KPI86453.1 - 7.5e-15 54.8 0.0 3.2e-11 43.2 0.0 2.6 2 0 0 2 2 2 2 Uncharacterised ACR, YggU family COG1872 Cnn_1N PF07989.11 KPI86456.1 - 1.5e-05 25.1 2.2 1.5e-05 25.1 2.2 6.9 4 3 1 5 5 5 1 Centrosomin N-terminal motif 1 HALZ PF02183.18 KPI86456.1 - 0.0018 18.5 20.7 0.11 12.7 0.2 5.8 5 0 0 5 5 5 2 Homeobox associated leucine zipper Fez1 PF06818.15 KPI86456.1 - 0.0091 16.5 19.4 0.0091 16.5 19.4 3.4 1 1 2 3 3 3 2 Fez1 CPG4 PF15481.6 KPI86456.1 - 0.38 11.4 4.6 1.3 9.7 4.6 2.0 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 WD40_alt PF14077.6 KPI86456.1 - 0.83 9.6 3.2 29 4.6 0.6 3.2 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF5631 PF18645.1 KPI86456.1 - 2.8 8.4 8.2 20 5.7 1.4 3.8 3 1 0 3 3 3 0 Family of unknown function (DUF5631) HA2 PF04408.23 KPI86459.1 - 1.7e-15 57.2 0.0 4.2e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI86459.1 - 6.3e-09 36.2 0.0 3.2e-08 33.9 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI86459.1 - 1.7e-07 31.2 0.1 3.6e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 KPI86459.1 - 0.0023 18.6 0.0 0.051 14.3 0.0 2.7 2 0 0 2 2 2 1 Double-stranded RNA binding motif AAA_22 PF13401.6 KPI86459.1 - 0.0059 16.9 0.5 0.024 14.9 0.3 2.1 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 KPI86459.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 KPI86459.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 KPI86459.1 - 0.17 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 KPI86459.1 - 0.24 11.3 0.0 0.45 10.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 KPI86459.1 - 0.26 11.8 0.0 0.5 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pex14_N PF04695.13 KPI86460.1 - 0.67 10.6 3.8 2.9 8.5 3.8 1.9 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hist_deacetyl PF00850.19 KPI86462.1 - 2e-56 191.7 0.0 2.6e-56 191.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Hydrolase_3 PF08282.12 KPI86463.1 - 0.094 12.4 0.0 14 5.3 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase zf-RING_2 PF13639.6 KPI86466.1 - 7.1e-06 26.3 16.4 7.1e-06 26.3 16.4 4.4 4 0 0 4 4 4 2 Ring finger domain zf-C3HC4 PF00097.25 KPI86466.1 - 0.0013 18.6 11.3 0.0013 18.6 11.3 4.2 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI86466.1 - 0.0073 16.3 11.3 0.0073 16.3 11.3 4.6 4 1 0 4 4 4 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KPI86466.1 - 0.013 15.3 15.1 0.013 15.3 15.1 5.0 5 1 0 5 5 5 0 Zinc finger, C3HC4 type (RING finger) TPR_1 PF00515.28 KPI86468.1 - 2.1e-53 176.1 37.8 1.2e-07 31.2 0.3 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86468.1 - 5.1e-43 141.7 33.5 0.0001 22.1 0.2 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 KPI86468.1 - 2.3e-29 100.8 31.2 2.8e-07 30.1 0.1 9.0 5 3 4 9 9 9 7 TPR repeat STI1 PF17830.1 KPI86468.1 - 3.6e-29 100.5 3.9 9.1e-16 57.5 0.9 3.7 3 0 0 3 3 3 2 STI1 domain TPR_19 PF14559.6 KPI86468.1 - 3.2e-19 69.2 8.9 0.00023 21.6 0.1 6.5 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86468.1 - 2.7e-18 64.6 33.2 0.0023 18.0 0.1 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86468.1 - 3.2e-18 65.8 20.2 5.8e-07 29.7 0.2 7.1 6 2 1 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86468.1 - 3e-17 61.8 8.9 0.68 10.9 0.0 9.1 4 3 5 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI86468.1 - 5.1e-17 62.2 15.6 0.00013 22.5 0.1 7.2 5 1 1 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 KPI86468.1 - 9.1e-11 41.4 20.5 0.0081 16.5 0.4 8.0 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI86468.1 - 9.9e-11 41.6 0.1 0.00046 20.3 0.0 4.3 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86468.1 - 6.4e-08 32.1 12.4 0.95 9.6 0.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI86468.1 - 9.3e-07 28.8 8.1 0.88 9.7 0.0 5.9 6 0 0 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 KPI86468.1 - 1.1e-06 28.3 21.0 0.0087 15.9 0.1 8.3 10 0 0 10 10 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI86468.1 - 1.3e-05 25.4 23.1 0.012 15.8 4.5 5.9 4 2 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 KPI86468.1 - 3.6e-05 23.1 5.0 1.1 8.8 0.0 5.7 6 0 0 6 6 6 1 SHNi-TPR TPR_6 PF13174.6 KPI86468.1 - 0.00017 22.0 21.1 4.2 8.2 0.1 8.6 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_20 PF14561.6 KPI86468.1 - 0.00025 21.3 0.5 1.6 9.1 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 KPI86468.1 - 0.0038 17.2 19.6 0.076 13.0 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPM_phosphatase PF04536.14 KPI86468.1 - 0.012 15.8 4.3 12 6.1 0.1 4.4 4 0 0 4 4 4 0 TPM domain BTAD PF03704.17 KPI86468.1 - 0.039 14.4 6.6 3.2 8.2 0.3 4.6 3 2 2 5 5 5 0 Bacterial transcriptional activator domain Imm74 PF15603.6 KPI86468.1 - 0.099 12.8 0.8 2.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 74 DUF3808 PF10300.9 KPI86468.1 - 0.15 10.8 3.9 0.3 9.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3808) SRP_TPR_like PF17004.5 KPI86468.1 - 0.16 12.0 16.0 0.6 10.1 0.2 4.7 3 2 2 5 5 5 0 Putative TPR-like repeat DnaI_N PF07319.11 KPI86468.1 - 0.18 12.5 2.5 4.9 7.9 0.0 3.6 3 1 0 3 3 2 0 Primosomal protein DnaI N-terminus MIT PF04212.18 KPI86468.1 - 0.25 11.4 0.1 0.25 11.4 0.1 8.1 8 1 2 10 10 7 0 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 KPI86468.1 - 0.28 11.3 11.7 13 5.9 0.2 5.8 3 3 1 5 5 5 0 Domain of Unknown Function (DUF3856) TPR_21 PF09976.9 KPI86468.1 - 0.72 9.5 17.3 4 7.1 0.2 5.1 2 2 2 5 5 5 0 Tetratricopeptide repeat-like domain Clathrin PF00637.20 KPI86468.1 - 4.9 7.0 8.1 0.89 9.4 0.7 3.3 3 1 1 4 4 4 0 Region in Clathrin and VPS DUF1126 PF06565.12 KPI86469.1 - 4.8e-58 193.5 0.0 1.9e-27 95.2 0.0 3.4 3 0 0 3 3 3 3 DUF1126 PH-like domain EF-hand_8 PF13833.6 KPI86469.1 - 0.00054 19.7 0.0 0.19 11.6 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI86469.1 - 0.00066 19.0 0.0 0.015 14.8 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KPI86469.1 - 0.0044 16.8 0.0 0.39 10.8 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KPI86469.1 - 0.013 14.9 0.0 0.032 13.7 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KPI86469.1 - 0.014 15.8 0.0 0.88 10.1 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain pair RHH_7 PF16777.5 KPI86469.1 - 0.031 14.7 0.0 16 6.0 0.0 2.7 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG Pribosyltran_N PF13793.6 KPI86470.1 - 4.3e-35 120.2 0.2 9.8e-35 119.0 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KPI86470.1 - 2.5e-22 79.8 0.8 1.7e-21 77.1 0.4 2.1 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KPI86470.1 - 1.3e-19 70.2 0.3 2.3e-19 69.4 0.3 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KPI86470.1 - 0.0099 15.3 0.1 0.018 14.5 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF4392 PF14336.6 KPI86470.1 - 0.015 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) Sec3_C PF09763.9 KPI86472.1 - 7e-75 252.8 0.2 6.8e-74 249.5 0.2 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec3 DUF812 PF05667.11 KPI86472.1 - 0.00033 19.7 3.7 0.00047 19.2 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) BRE1 PF08647.11 KPI86472.1 - 0.00075 19.5 4.1 0.00075 19.5 4.1 2.3 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase YabA PF06156.13 KPI86472.1 - 0.0062 17.2 0.9 0.019 15.6 0.9 1.9 1 0 0 1 1 1 1 Initiation control protein YabA Exonuc_VII_L PF02601.15 KPI86472.1 - 0.054 13.1 3.1 0.12 12.0 3.1 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Phage_GPO PF05929.11 KPI86472.1 - 2.6 7.6 6.2 5.2 6.6 6.2 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FliD_N PF02465.18 KPI86472.1 - 8.6 7.1 6.3 11 6.8 0.2 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TPMT PF05724.11 KPI86473.1 - 5.7e-19 68.6 0.5 1.2e-18 67.6 0.0 1.6 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 KPI86473.1 - 0.00035 20.5 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI86473.1 - 0.0038 17.9 0.0 0.0089 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Slu7 PF11708.8 KPI86475.1 - 1.6e-05 24.9 4.6 5.1e-05 23.2 4.6 2.0 1 1 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_3 PF13917.6 KPI86475.1 - 1.9 8.5 7.3 0.16 11.9 2.2 1.9 2 0 0 2 2 2 0 Zinc knuckle PALP PF00291.25 KPI86476.1 - 4.6e-77 259.3 3.8 6.3e-77 258.9 3.8 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 KPI86476.1 - 0.0016 18.1 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 KPI86476.1 - 0.022 15.3 0.0 0.097 13.3 0.0 2.0 2 0 0 2 2 2 0 ACT domain ANAPC4_WD40 PF12894.7 KPI86477.1 - 1.1e-11 44.9 2.8 0.12 12.7 0.1 6.1 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KPI86477.1 - 5.8e-11 42.1 3.1 0.00076 18.6 0.1 4.2 4 0 0 4 4 4 2 Coatomer WD associated region TPR_12 PF13424.6 KPI86477.1 - 0.0019 18.4 10.9 0.6 10.4 1.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-RanBP PF00641.18 KPI86477.1 - 0.0042 16.4 3.5 0.0042 16.4 3.5 2.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Clathrin PF00637.20 KPI86477.1 - 0.0057 16.5 3.1 5.9 6.8 0.2 4.2 2 1 2 4 4 4 1 Region in Clathrin and VPS TPR_14 PF13428.6 KPI86477.1 - 0.029 15.2 14.2 0.053 14.4 1.4 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86477.1 - 0.035 14.6 4.0 1.7 9.2 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 KPI86477.1 - 0.099 13.6 16.0 0.6 11.1 0.0 7.1 8 1 0 8 8 6 0 WD domain, G-beta repeat Vps39_1 PF10366.9 KPI86477.1 - 0.12 12.6 0.3 0.42 10.9 0.3 1.9 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 KPI86477.1 - 0.49 10.6 20.2 0.62 10.3 0.6 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86477.1 - 0.54 10.4 6.7 1.6 8.9 0.2 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI86477.1 - 0.6 10.4 11.9 1.9 8.8 0.1 4.0 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DZR PF12773.7 KPI86477.1 - 1.1 9.3 10.7 9.6 6.3 10.7 2.4 1 1 0 1 1 1 0 Double zinc ribbon Cytochrome_C7 PF14522.6 KPI86477.1 - 1.3 9.0 7.8 3.8 7.6 7.8 1.8 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c DUF3716 PF12511.8 KPI86477.1 - 7.6 6.7 10.8 14 5.8 8.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) MIX PF18529.1 KPI86478.1 - 7.5e-97 321.1 1.2 8.7e-97 320.9 1.2 1.0 1 0 0 1 1 1 1 Mitochondrial membrane-anchored proteins PARP PF00644.20 KPI86479.1 - 1.1e-65 220.9 0.1 1.8e-65 220.2 0.1 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 KPI86479.1 - 8.2e-41 139.3 0.7 1.3e-40 138.7 0.7 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 KPI86479.1 - 5.3e-22 77.7 0.4 1.2e-21 76.5 0.0 1.9 2 0 0 2 2 2 1 WGR domain PH_TFIIH PF08567.11 KPI86479.1 - 0.38 11.1 4.8 13 6.2 0.7 2.7 1 1 2 3 3 3 0 TFIIH p62 subunit, N-terminal domain zf-C3HC4 PF00097.25 KPI86481.1 - 9.2e-09 35.0 6.9 1.8e-08 34.1 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI86481.1 - 1e-07 31.8 5.9 2.2e-07 30.7 5.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KPI86481.1 - 3e-07 30.2 10.0 7.9e-07 28.8 8.5 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI86481.1 - 5.5e-07 29.5 2.1 5.5e-07 29.5 2.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KPI86481.1 - 1.4e-06 28.1 6.5 2.6e-06 27.2 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI86481.1 - 2.8e-06 27.4 8.5 6.6e-06 26.2 8.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KPI86481.1 - 7.1e-06 26.3 8.4 1.3e-05 25.4 8.4 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KPI86481.1 - 0.003 17.4 5.9 0.0062 16.4 5.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KPI86481.1 - 0.011 16.0 5.3 0.032 14.5 5.3 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KPI86481.1 - 0.068 13.2 1.9 0.14 12.2 1.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 KPI86481.1 - 0.094 12.9 0.0 0.31 11.3 0.2 1.8 2 0 0 2 2 1 0 U-box domain zf-MIZ PF02891.20 KPI86481.1 - 1.1 9.1 7.0 2.4 8.0 7.0 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KPI86481.1 - 2.6 7.9 5.6 5.2 7.0 5.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.21 KPI86481.1 - 6.7 6.9 7.6 0.74 10.0 2.4 2.1 2 0 0 2 2 2 0 FYVE zinc finger Zn_Tnp_IS1595 PF12760.7 KPI86481.1 - 8 6.5 7.1 2.3 8.3 0.2 2.4 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-RING_11 PF17123.5 KPI86481.1 - 9.9 6.0 6.8 34 4.3 6.8 2.0 1 1 0 1 1 1 0 RING-like zinc finger Lebercilin PF15619.6 KPI86482.1 - 0.34 10.5 8.9 2.7 7.6 3.8 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF2066 PF09839.9 KPI86484.1 - 0.02 14.3 0.1 0.033 13.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2066) Amidinotransf PF02274.17 KPI86485.1 - 2.2e-10 40.2 0.0 4.8e-10 39.1 0.0 1.4 1 1 1 2 2 2 1 Amidinotransferase Pkinase PF00069.25 KPI86486.1 - 9.7e-47 159.5 0.0 2.9e-46 158.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86486.1 - 3.3e-37 128.2 0.0 5.3e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KPI86486.1 - 0.0046 16.6 0.0 0.0072 15.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KPI86486.1 - 0.098 11.4 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Syja_N PF02383.18 KPI86489.1 - 9.9e-23 80.9 0.0 2e-22 79.9 0.0 1.5 1 1 0 1 1 1 1 SacI homology domain NPR3 PF03666.13 KPI86489.1 - 0.55 8.9 2.7 1.1 8.0 2.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPR_2 PF13041.6 KPI86490.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 PPR repeat family Raf1_HTH PF18579.1 KPI86490.1 - 0.17 11.6 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain Methyltransf_23 PF13489.6 KPI86491.1 - 4.9e-23 81.8 0.0 6.9e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI86491.1 - 4.8e-17 62.4 0.0 9.5e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI86491.1 - 4.6e-15 55.7 0.0 9e-15 54.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI86491.1 - 4.4e-14 53.0 0.1 1.1e-13 51.7 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI86491.1 - 4.2e-13 49.9 0.0 7.9e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KPI86491.1 - 7.4e-08 32.0 0.0 2.1e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 KPI86491.1 - 7.8e-07 28.8 0.0 1.1e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 KPI86491.1 - 1.8e-05 24.4 0.2 0.00012 21.8 0.2 1.9 1 1 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 KPI86491.1 - 0.0001 22.3 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI86491.1 - 0.00065 19.3 0.0 0.0013 18.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Pox_MCEL PF03291.16 KPI86491.1 - 0.002 17.3 0.0 0.0029 16.8 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme TehB PF03848.14 KPI86491.1 - 0.0033 16.9 0.0 0.0086 15.5 0.0 1.7 1 1 0 1 1 1 1 Tellurite resistance protein TehB PCMT PF01135.19 KPI86491.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 KPI86491.1 - 0.012 15.7 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DREV PF05219.12 KPI86491.1 - 0.035 13.2 0.0 0.057 12.5 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase MetW PF07021.12 KPI86491.1 - 0.17 11.5 0.2 1.3 8.6 0.2 2.1 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW FYVE PF01363.21 KPI86492.1 - 2.2e-17 63.0 15.2 2.8e-16 59.4 7.8 2.5 2 0 0 2 2 2 2 FYVE zinc finger Caldesmon PF02029.15 KPI86492.1 - 0.0062 15.4 37.4 0.0077 15.0 37.4 1.1 1 0 0 1 1 1 1 Caldesmon SRP-alpha_N PF04086.13 KPI86492.1 - 0.12 12.3 28.9 0.16 11.8 28.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Zn_ribbon_SprT PF17283.2 KPI86492.1 - 0.24 11.4 9.1 0.11 12.5 1.6 3.0 1 1 1 2 2 2 0 SprT-like zinc ribbon domain Asp-B-Hydro_N PF05279.11 KPI86492.1 - 1.4 8.9 35.1 2 8.4 35.1 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Zn-ribbon_8 PF09723.10 KPI86492.1 - 1.5 9.0 14.7 9.7 6.4 0.3 4.3 3 1 0 3 3 3 0 Zinc ribbon domain Ndc1_Nup PF09531.10 KPI86492.1 - 1.6 7.3 7.7 2 7.0 7.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DZR PF12773.7 KPI86492.1 - 2.6 8.1 16.2 1.3e+02 2.7 16.3 2.8 1 1 0 1 1 1 0 Double zinc ribbon GREB1 PF15782.5 KPI86492.1 - 6.2 3.8 15.2 7.4 3.5 15.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 KPI86492.1 - 8.7 5.9 27.3 13 5.3 27.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) SAS-6_N PF16531.5 KPI86494.1 - 1.9e-19 70.0 0.0 4.6e-19 68.8 0.0 1.7 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal DUF16 PF01519.16 KPI86494.1 - 1.4 9.5 36.5 0.027 15.0 7.1 4.1 1 1 3 4 4 4 0 Protein of unknown function DUF16 Spc7 PF08317.11 KPI86494.1 - 8.9 5.1 58.1 0.22 10.4 20.4 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF4633 PF15464.6 KPI86497.1 - 0.29 11.3 3.0 0.2 11.8 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) DUF2723 PF11028.8 KPI86498.1 - 0.0032 17.4 1.2 0.0042 17.0 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) Methyltrn_RNA_3 PF02598.17 KPI86498.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.6 1 1 0 1 1 1 0 Putative RNA methyltransferase Hydrolase_6 PF13344.6 KPI86499.1 - 6e-22 77.7 0.0 1.4e-21 76.5 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KPI86499.1 - 2.7e-13 49.8 0.0 8.7e-13 48.1 0.0 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KPI86499.1 - 0.0037 17.6 0.0 2.1 8.6 0.0 2.8 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ArAE_1_C PF11728.8 KPI86500.1 - 0.042 13.9 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain PIH1 PF08190.12 KPI86501.1 - 7.2e-60 201.2 0.3 7.2e-60 201.2 0.3 1.7 2 0 0 2 2 2 1 PIH1 N-terminal domain PIH1_CS PF18201.1 KPI86501.1 - 1.2e-19 70.6 0.0 2.6e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 PIH1 CS-like domain HBS1_N PF08938.10 KPI86502.1 - 0.06 13.6 0.2 0.3 11.4 0.0 2.3 2 0 0 2 2 2 0 HBS1 N-terminus PrgU PF09627.10 KPI86502.1 - 0.065 13.2 0.1 6.5 6.8 0.0 2.4 2 0 0 2 2 2 0 PrgU-like protein PGAP1 PF07819.13 KPI86503.1 - 3.6e-14 53.1 0.0 1.3e-05 25.1 0.0 2.7 2 1 0 2 2 2 2 PGAP1-like protein Abhydrolase_1 PF00561.20 KPI86503.1 - 0.0046 16.6 0.0 0.014 15.0 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI86503.1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DNA_pol_B_exo1 PF03104.19 KPI86504.1 - 1.2e-56 192.3 0.1 2e-56 191.6 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.12 KPI86504.1 - 1.1e-53 182.3 0.0 2.8e-52 177.6 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.21 KPI86504.1 - 3.3e-11 42.6 0.1 3.4e-08 32.7 0.1 3.1 3 0 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 KPI86504.1 - 1.4e-09 37.9 0.1 1.4e-07 31.4 0.0 2.4 2 0 0 2 2 2 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 KPI86504.1 - 4.9e-08 33.1 0.2 1.8e-07 31.3 0.1 2.0 2 1 0 2 2 2 1 RNase_H superfamily DUF348 PF03990.14 KPI86504.1 - 0.16 11.8 0.6 0.55 10.0 0.6 2.0 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain Orthopox_A36R PF05950.11 KPI86504.1 - 0.22 11.7 1.1 0.48 10.6 1.1 1.5 1 0 0 1 1 1 0 Orthopoxvirus A36R protein zf-3CxxC PF13695.6 KPI86505.1 - 2.5e-06 27.9 5.8 3.3e-06 27.5 5.8 1.4 1 1 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.4 KPI86505.1 - 5.8e-05 23.8 4.8 0.00011 22.9 4.8 1.5 1 1 0 1 1 1 1 Zinc-binding domain XdhC_C PF13478.6 KPI86506.1 - 0.011 16.2 0.1 0.017 15.6 0.1 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain DUF3583 PF12126.8 KPI86507.1 - 0.064 12.7 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) zf-CCCH PF00642.24 KPI86508.1 - 5.9e-06 26.0 6.0 1.1e-05 25.2 6.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI86508.1 - 0.0012 18.8 8.4 0.0019 18.2 8.4 1.3 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 KPI86508.1 - 0.029 15.1 0.3 0.047 14.4 0.3 1.3 1 0 0 1 1 1 0 Torus domain Rax2 PF12768.7 KPI86510.1 - 0.059 12.8 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Endonuclease_NS PF01223.23 KPI86511.1 - 2e-49 168.4 0.0 1e-48 166.2 0.0 2.1 2 1 0 2 2 2 1 DNA/RNA non-specific endonuclease ABC1 PF03109.16 KPI86512.1 - 1.1e-21 77.2 0.0 2.2e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 ABC1 family TAT_signal PF10518.9 KPI86512.1 - 0.029 14.2 0.1 0.065 13.1 0.1 1.6 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence CAF1A PF12253.8 KPI86514.1 - 3.6e-06 27.1 8.3 3.6e-06 27.1 8.3 4.5 4 1 0 4 4 4 1 Chromatin assembly factor 1 subunit A Utp14 PF04615.13 KPI86514.1 - 1.1 7.8 48.9 0.032 12.8 11.2 2.2 2 0 0 2 2 2 0 Utp14 protein ADH_zinc_N PF00107.26 KPI86515.1 - 1.9e-17 63.5 0.0 3.2e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KPI86515.1 - 2.1e-14 54.7 0.1 3.6e-14 54.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI86515.1 - 0.00014 21.7 0.0 0.00047 20.0 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI86516.1 - 1.9e-14 53.8 0.0 3.1e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI86516.1 - 5e-10 39.2 0.6 4.4e-09 36.2 0.5 2.3 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KPI86516.1 - 1e-09 39.5 0.0 1.5e-09 39.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_synthase PF01645.17 KPI86516.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Conserved region in glutamate synthase Ppnp PF06865.11 KPI86518.1 - 0.11 13.0 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 Pyrimidine/purine nucleoside phosphorylase DUF3837 PF12939.7 KPI86519.1 - 0.077 13.4 0.2 0.51 10.8 0.2 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) PrmA PF06325.13 KPI86519.1 - 8.1 5.7 9.8 0.59 9.5 3.1 2.4 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) BASP1 PF05466.12 KPI86520.1 - 3.6 7.6 7.6 11 5.9 7.6 1.8 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) PfkB PF00294.24 KPI86521.1 - 2.4e-22 79.6 0.0 3.8e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NAD_Gly3P_dh_C PF07479.14 KPI86523.1 - 1.2e-42 145.5 0.4 2.9e-42 144.3 0.1 1.8 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 KPI86523.1 - 2.1e-40 138.3 0.0 3.4e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 KPI86523.1 - 0.001 18.7 0.0 0.0021 17.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 KPI86523.1 - 0.023 14.9 0.5 0.054 13.7 0.0 1.9 3 0 0 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 KPI86523.1 - 0.056 14.0 0.1 0.31 11.6 0.1 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 KPI86523.1 - 0.076 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF4713 PF15831.5 KPI86524.1 - 1.4 9.4 4.6 4.9 7.7 4.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) RabGAP-TBC PF00566.18 KPI86525.1 - 5.4e-28 98.1 0.2 9.5e-16 58.1 0.0 3.5 4 0 0 4 4 4 3 Rab-GTPase-TBC domain FtsJ PF01728.19 KPI86526.1 - 7.7e-58 195.5 0.0 1.3e-57 194.8 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 KPI86526.1 - 2.2e-31 109.1 17.8 2.2e-31 109.1 17.8 3.4 2 1 2 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.8 KPI86526.1 - 4.5e-30 104.6 4.5 4.5e-30 104.6 4.5 4.8 3 2 0 4 4 4 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 KPI86526.1 - 0.0036 17.2 0.0 0.07 13.0 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain TrmB PF01978.19 KPI86526.1 - 0.0091 15.9 0.3 0.028 14.3 0.3 1.9 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB LSM PF01423.22 KPI86527.1 - 3e-16 58.9 0.1 3.7e-16 58.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain IFT43 PF15305.6 KPI86528.1 - 3.2e-05 24.1 1.5 3.2e-05 24.1 1.5 2.2 2 0 0 2 2 2 1 Intraflagellar transport protein 43 Dpy-30 PF05186.13 KPI86529.1 - 6.7e-07 28.9 0.1 1.7e-06 27.6 0.1 1.8 1 0 0 1 1 1 1 Dpy-30 motif PhoD PF09423.10 KPI86529.1 - 0.0074 15.4 0.1 0.014 14.5 0.1 1.4 1 0 0 1 1 1 1 PhoD-like phosphatase Hydin_ADK PF17213.3 KPI86529.1 - 0.016 15.5 0.3 0.016 15.5 0.3 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Pkinase PF00069.25 KPI86530.1 - 5.6e-45 153.8 0.0 1e-41 143.1 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86530.1 - 2.5e-22 79.4 0.0 1.7e-21 76.7 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI86530.1 - 9.8e-07 28.4 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KPI86530.1 - 0.00024 20.2 0.0 0.0004 19.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI86530.1 - 0.024 14.6 0.6 0.1 12.5 0.0 2.3 3 0 0 3 3 3 0 Phosphotransferase enzyme family PTN13_u3 PF16599.5 KPI86531.1 - 1.7 8.7 12.2 9.1 6.3 1.2 3.8 3 1 1 4 4 4 0 Unstructured linker region on PTN13 protein between PDZ DUF4189 PF13827.6 KPI86532.1 - 0.4 11.2 7.1 0.19 12.3 2.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4189) Cmc1 PF08583.10 KPI86532.1 - 0.66 10.0 13.5 4.8 7.3 0.4 3.2 2 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like SRCR PF00530.18 KPI86532.1 - 0.97 10.0 8.3 0.64 10.5 4.0 2.1 1 1 1 2 2 2 0 Scavenger receptor cysteine-rich domain DUF3128 PF11326.8 KPI86532.1 - 3.8 8.0 11.9 42 4.6 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) CHCH PF06747.13 KPI86532.1 - 6.3 7.1 9.5 1.5 9.0 0.4 3.0 3 0 0 3 3 3 0 CHCH domain DUF846 PF05832.12 KPI86533.1 - 2.8e-45 153.7 6.8 3.5e-45 153.5 6.8 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF4262 PF14081.6 KPI86534.1 - 0.1 12.8 0.3 0.57 10.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4262) Mre11_DNA_bind PF04152.14 KPI86535.1 - 9.2e-29 100.9 0.5 2e-27 96.6 0.0 2.8 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 KPI86535.1 - 6.2e-14 53.0 0.3 1e-13 52.3 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase YCII PF03795.14 KPI86536.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 YCII-related domain GSP_synth PF03738.14 KPI86537.1 - 1.8e-70 238.0 0.0 2.3e-70 237.7 0.0 1.1 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CHAP PF05257.16 KPI86537.1 - 4.2e-11 43.3 0.7 1e-10 42.1 0.0 2.1 2 0 0 2 2 2 1 CHAP domain Flagellar_rod PF05149.12 KPI86539.1 - 1.1e-100 336.9 25.0 2.4e-100 335.7 25.0 1.6 1 0 0 1 1 1 1 Paraflagellar rod protein SH3_9 PF14604.6 KPI86539.1 - 2.2e-12 46.6 0.0 5.8e-12 45.3 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KPI86539.1 - 6.9e-10 38.4 0.0 1.4e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KPI86539.1 - 1e-08 34.7 0.0 2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Mlp PF03304.13 KPI86539.1 - 0.36 11.0 9.4 18 5.5 7.7 2.7 2 1 0 2 2 2 0 Mlp lipoprotein family Cnl2_NKP2 PF09447.10 KPI86539.1 - 1.4 9.2 6.2 1.5 9.1 0.5 3.4 3 0 0 3 3 3 0 Cnl2/NKP2 family protein DSPc PF00782.20 KPI86540.1 - 6e-23 81.1 0.0 9.6e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI86540.1 - 0.00022 20.9 0.0 0.0004 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase YchF-GTPase_C PF06071.13 KPI86541.1 - 1.5e-25 89.2 0.1 2.7e-25 88.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KPI86541.1 - 2.1e-20 72.9 0.0 4.2e-20 71.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI86541.1 - 9.4e-09 35.0 0.0 2.5e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.21 KPI86541.1 - 7.7e-05 22.7 0.0 0.00015 21.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain MeaB PF03308.16 KPI86541.1 - 0.043 12.8 0.0 0.12 11.3 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 KPI86541.1 - 0.085 13.4 0.0 1.5 9.3 0.0 2.3 2 0 0 2 2 2 0 ABC transporter RasGAP_C PF03836.15 KPI86542.1 - 0.0076 16.4 4.6 0.0076 16.4 4.6 10.0 9 2 1 10 10 10 4 RasGAP C-terminus Acetyltransf_1 PF00583.25 KPI86543.1 - 2.1e-17 63.4 0.0 2.5e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KPI86543.1 - 1.4e-10 41.2 0.0 1.9e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI86543.1 - 1.2e-09 38.5 0.1 1.7e-09 37.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KPI86543.1 - 6.6e-06 26.2 0.0 8.3e-06 25.9 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KPI86543.1 - 2.7e-05 24.2 0.1 3.8e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 KPI86543.1 - 0.021 15.5 0.0 0.023 15.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI86543.1 - 0.039 13.9 0.0 0.091 12.7 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein DNA_pol_B_palm PF14792.6 KPI86543.1 - 0.074 13.3 0.1 0.086 13.0 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase beta palm CARD PF00619.21 KPI86543.1 - 0.08 13.0 0.0 0.37 10.8 0.0 1.9 2 0 0 2 2 2 0 Caspase recruitment domain Acetyltransf_13 PF13880.6 KPI86543.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.6 1 1 0 1 1 1 0 ESCO1/2 acetyl-transferase GNAT_acetyltran PF12746.7 KPI86543.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Pkinase PF00069.25 KPI86544.1 - 6.2e-44 150.3 0.0 8.3e-44 149.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86544.1 - 2e-31 109.2 0.0 2.4e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI86544.1 - 1.7e-08 33.7 0.0 2.4e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KPI86544.1 - 2.6e-07 30.2 0.0 3.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI86544.1 - 0.059 13.3 0.1 0.097 12.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI86544.1 - 0.083 11.8 0.0 0.14 11.0 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain CDKN3 PF05706.12 KPI86545.1 - 0.0069 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) CheD PF03975.13 KPI86545.1 - 0.07 13.2 1.4 0.1 12.7 0.1 1.9 2 1 0 2 2 2 0 CheD chemotactic sensory transduction NEMO PF11577.8 KPI86548.1 - 0.072 13.1 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO FHA PF00498.26 KPI86548.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 FHA domain PQQ_3 PF13570.6 KPI86549.1 - 1.9 9.1 10.6 6.6 7.4 0.3 5.1 5 1 1 6 6 6 0 PQQ-like domain zf-CCCH_4 PF18044.1 KPI86550.1 - 0.0038 17.0 0.5 0.0038 17.0 0.5 2.3 2 1 0 2 2 2 1 CCCH-type zinc finger zf-CCCH PF00642.24 KPI86550.1 - 0.019 14.9 6.0 0.97 9.4 1.1 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI86550.1 - 1.9 8.6 8.8 0.15 12.2 2.2 2.2 2 0 0 2 2 2 0 Zinc finger domain KAR9 PF08580.10 KPI86551.1 - 2.7 6.4 6.3 3.9 5.9 6.3 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Na_sulph_symp PF00939.19 KPI86552.1 - 8.9e-20 71.2 47.8 2.2e-18 66.6 47.8 2.9 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KPI86552.1 - 2.1e-16 60.0 50.5 2.1e-16 60.0 50.5 1.6 1 1 0 1 1 1 1 Citrate transporter SPX PF03105.19 KPI86552.1 - 5.2e-12 46.4 7.0 9.6e-10 38.9 0.4 2.3 1 1 1 2 2 2 2 SPX domain ELFV_dehydrog PF00208.21 KPI86554.1 - 4.1e-84 282.1 2.3 5.7e-84 281.6 2.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 KPI86554.1 - 1.6e-51 173.6 0.0 5.2e-51 171.9 0.0 1.9 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 KPI86554.1 - 0.0012 19.3 0.2 0.0023 18.3 0.2 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 KPI86554.1 - 0.0014 18.0 0.9 0.13 11.6 0.1 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 KPI86554.1 - 0.11 11.9 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Dor1 PF04124.12 KPI86555.1 - 6.6e-20 71.1 1.7 9.2e-20 70.6 1.7 1.1 1 0 0 1 1 1 1 Dor1-like family Peptidase_C39 PF03412.15 KPI86555.1 - 0.15 11.8 0.3 0.8 9.5 0.1 2.1 2 0 0 2 2 2 0 Peptidase C39 family Pox_I1 PF03289.13 KPI86556.1 - 0.0095 15.1 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 1 Poxvirus protein I1 AAA_6 PF12774.7 KPI86557.1 - 4.2e-150 499.2 0.0 9.6e-150 498.1 0.0 1.7 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI86557.1 - 7.5e-104 348.0 3.0 7.5e-104 348.0 3.0 3.3 3 0 0 3 3 2 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI86557.1 - 2e-101 338.7 0.0 9.9e-101 336.4 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KPI86557.1 - 1.8e-85 286.9 0.0 1.4e-84 283.9 0.0 2.8 2 0 0 2 2 1 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KPI86557.1 - 7.5e-79 263.9 0.1 1.3e-76 256.6 0.1 3.0 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI86557.1 - 5.3e-71 237.9 0.4 4.8e-65 218.5 0.0 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI86557.1 - 1.6e-52 177.7 0.0 4.7e-52 176.1 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI86557.1 - 2.4e-42 143.8 0.1 1e-40 138.5 0.0 3.6 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI86557.1 - 4e-39 134.6 10.4 7.3e-39 133.8 10.4 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KPI86557.1 - 7e-26 90.9 0.0 9.1e-07 29.0 0.0 6.0 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KPI86557.1 - 1.4e-25 89.9 0.1 5.6e-25 87.9 0.1 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KPI86557.1 - 8.9e-11 41.9 0.0 3.7e-10 39.9 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 KPI86557.1 - 1.7e-09 38.2 0.3 0.063 13.7 0.0 5.1 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI86557.1 - 7e-07 29.8 7.8 1.4 9.2 0.0 6.6 6 1 0 6 6 4 3 AAA ATPase domain AAA_22 PF13401.6 KPI86557.1 - 1.2e-06 28.9 5.2 1.9 8.7 0.0 5.8 5 0 0 5 5 4 3 AAA domain AAA_18 PF13238.6 KPI86557.1 - 3.5e-05 24.4 0.2 0.095 13.2 0.0 4.9 5 0 0 5 5 4 1 AAA domain Sigma54_activat PF00158.26 KPI86557.1 - 0.00011 22.0 0.4 0.062 13.0 0.0 3.9 4 0 0 4 4 4 1 Sigma-54 interaction domain AAA_14 PF13173.6 KPI86557.1 - 0.001 19.1 0.0 0.67 10.0 0.0 3.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KPI86557.1 - 0.0026 18.1 0.0 0.38 11.2 0.0 3.7 3 0 0 3 3 3 1 RNA helicase DUF853 PF05872.12 KPI86557.1 - 0.0036 16.0 0.5 0.15 10.6 0.1 2.6 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) AAA_33 PF13671.6 KPI86557.1 - 0.034 14.3 0.9 30 4.8 0.0 4.4 4 0 0 4 4 3 0 AAA domain AAA_lid_7 PF17867.1 KPI86557.1 - 0.036 14.3 0.0 0.17 12.1 0.0 2.2 1 0 0 1 1 1 0 Midasin AAA lid domain NACHT PF05729.12 KPI86557.1 - 0.038 13.9 0.4 6 6.8 0.0 3.6 4 0 0 4 4 2 0 NACHT domain Mg_chelatase PF01078.21 KPI86557.1 - 0.064 12.6 0.5 4.6 6.6 0.0 3.6 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI ResIII PF04851.15 KPI86557.1 - 0.067 13.2 5.5 0.16 12.0 0.0 4.0 5 0 0 5 5 4 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 KPI86557.1 - 0.21 11.2 5.3 6.3 6.4 0.1 4.3 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain ETC_C1_NDUFA5 PF04716.14 KPI86557.1 - 0.72 9.7 0.0 0.72 9.7 0.0 3.8 4 0 0 4 4 2 0 ETC complex I subunit conserved region AAA_19 PF13245.6 KPI86557.1 - 1.3 9.4 4.3 60 4.0 0.0 4.2 4 0 0 4 4 3 0 AAA domain BLOC1_2 PF10046.9 KPI86557.1 - 8.4 6.8 11.0 1.7 9.0 0.4 5.0 4 0 0 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHHA1 PF02272.19 KPI86557.1 - 9.7 6.6 7.0 11 6.5 0.8 4.1 4 0 0 4 4 3 0 DHHA1 domain ARGLU PF15346.6 KPI86561.1 - 0.11 12.3 11.5 1.3 8.9 3.3 2.2 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Jas PF16135.5 KPI86562.1 - 0.16 12.2 0.4 0.36 11.1 0.4 1.6 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling VEGF_C PF14554.6 KPI86562.1 - 3.6 7.7 6.8 1.4 9.1 0.1 3.5 3 0 0 3 3 3 0 VEGF heparin-binding domain IQ PF00612.27 KPI86562.1 - 5.8 7.0 9.2 0.12 12.3 1.4 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif HSP70 PF00012.20 KPI86563.1 - 8.6e-196 651.7 4.7 1.1e-195 651.4 4.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KPI86563.1 - 2.5e-15 56.1 2.9 1.3e-12 47.2 0.2 2.6 3 0 0 3 3 3 2 MreB/Mbl protein BcrAD_BadFG PF01869.20 KPI86563.1 - 0.0013 18.3 0.1 0.048 13.2 0.0 3.0 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Gp-FAR-1 PF05823.12 KPI86563.1 - 0.0038 17.6 1.7 0.009 16.4 1.7 1.6 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) FtsA PF14450.6 KPI86563.1 - 0.031 14.7 4.6 1.6 9.2 0.0 3.7 3 3 0 3 3 3 0 Cell division protein FtsA Phage_TAC_11 PF11836.8 KPI86563.1 - 0.13 12.4 1.5 0.62 10.2 0.0 2.7 2 0 0 2 2 2 0 Phage tail tube protein, GTA-gp10 She9_MDM33 PF05546.11 KPI86563.1 - 0.31 10.8 2.6 0.73 9.6 2.6 1.6 1 1 0 1 1 1 0 She9 / Mdm33 family Raco_middle PF17651.1 KPI86563.1 - 0.31 10.7 1.6 0.49 10.1 0.0 2.1 3 0 0 3 3 3 0 RACo middle region DUF3168 PF11367.8 KPI86563.1 - 2.3 8.4 11.1 2.8 8.2 0.1 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF3168) Med3 PF11593.8 KPI86564.1 - 1 8.5 6.1 1.3 8.1 6.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Beta-lactamase PF00144.24 KPI86565.1 - 1.4e-09 37.7 0.0 7.2e-09 35.3 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase ABC_tran_CTD PF16326.5 KPI86566.1 - 0.028 14.7 0.8 0.028 14.7 0.8 4.4 4 1 1 5 5 5 0 ABC transporter C-terminal domain MPS2 PF17060.5 KPI86566.1 - 0.45 9.7 4.6 1.1 8.4 0.4 2.3 2 0 0 2 2 2 0 Monopolar spindle protein 2 EzrA PF06160.12 KPI86566.1 - 0.58 8.3 6.8 0.047 11.9 0.4 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA YkyA PF10368.9 KPI86566.1 - 2.4 7.8 8.6 1.2 8.7 0.7 3.0 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein HALZ PF02183.18 KPI86566.1 - 3.1 8.1 16.9 1.9 8.8 0.3 4.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper SH2_2 PF14633.6 KPI86569.1 - 6.5e-20 71.5 0.1 1.1e-19 70.8 0.1 1.3 1 0 0 1 1 1 1 SH2 domain YqgF PF14639.6 KPI86569.1 - 3.6e-14 52.8 0.0 8.3e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 Tex_YqgF PF16921.5 KPI86569.1 - 7.1e-05 23.3 0.0 0.00015 22.2 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain S1 PF00575.23 KPI86569.1 - 0.0023 18.3 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 S1 RNA binding domain HHH_7 PF14635.6 KPI86569.1 - 0.14 12.5 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif PSDC PF12588.8 KPI86571.1 - 0.066 13.2 0.1 7.8 6.5 0.0 3.2 4 0 0 4 4 4 0 Phophatidylserine decarboxylase Trypsin PF00089.26 KPI86572.1 - 5.4e-05 23.1 0.0 0.0017 18.2 0.0 2.0 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.6 KPI86572.1 - 0.00017 22.5 0.0 0.00046 21.1 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.15 KPI86572.1 - 0.17 11.7 0.8 0.38 10.5 0.3 1.8 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease Ribosomal_S13_N PF08069.12 KPI86574.1 - 4.5e-25 87.5 1.5 8.6e-25 86.6 1.5 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 KPI86574.1 - 2.7e-13 49.9 0.9 4.5e-13 49.2 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 DDE_Tnp_ISL3 PF01610.17 KPI86575.1 - 0.038 13.7 0.3 0.084 12.6 0.3 1.6 1 0 0 1 1 1 0 Transposase Amelogenin PF02948.15 KPI86575.1 - 0.078 13.6 0.1 0.078 13.6 0.1 1.7 2 0 0 2 2 2 0 Amelogenin DUF4795 PF16043.5 KPI86576.1 - 0.023 14.3 1.2 0.087 12.4 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DASH_Spc34 PF08657.10 KPI86576.1 - 0.027 14.3 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Spc34 DUF1664 PF07889.12 KPI86576.1 - 0.035 14.1 3.9 3.8 7.6 0.1 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Dynactin_p22 PF07426.11 KPI86576.1 - 0.047 13.5 0.7 0.82 9.5 0.0 2.9 2 1 1 3 3 3 0 Dynactin subunit p22 Spc7 PF08317.11 KPI86576.1 - 0.066 12.1 1.0 0.87 8.4 0.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Amidohydro_1 PF01979.20 KPI86576.1 - 0.13 11.5 0.3 0.29 10.4 0.0 1.6 2 0 0 2 2 2 0 Amidohydrolase family DivIVA PF05103.13 KPI86576.1 - 0.19 11.8 1.4 7.2 6.7 0.6 2.8 2 1 0 2 2 2 0 DivIVA protein ZapB PF06005.12 KPI86576.1 - 9.5 6.8 9.6 5.4 7.5 0.9 3.5 4 1 0 4 4 4 0 Cell division protein ZapB EphA2_TM PF14575.6 KPI86577.1 - 2.2e-06 28.5 9.2 9.4 7.2 0.8 6.1 3 2 1 5 5 5 3 Ephrin type-A receptor 2 transmembrane domain DUF2782 PF11191.8 KPI86577.1 - 0.043 14.0 0.4 36 4.6 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2782) Dockerin_1 PF00404.18 KPI86577.1 - 0.062 13.5 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 Dockerin type I domain Metallothio_Cad PF07846.11 KPI86577.1 - 0.37 11.0 4.3 1.2e+02 2.9 0.0 4.7 8 0 0 8 8 8 0 Metallothionein family PepSY PF03413.19 KPI86577.1 - 0.86 10.2 20.7 3.4 8.3 1.4 6.0 5 1 0 5 5 5 0 Peptidase propeptide and YPEB domain Arm-DNA-bind_1 PF09003.10 KPI86577.1 - 2.1 8.6 7.8 56 4.0 0.1 4.4 3 1 2 5 5 5 0 Bacteriophage lambda integrase, Arm DNA-binding domain RunxI PF08504.11 KPI86577.1 - 5.5 7.8 16.6 7.1 7.4 1.3 4.9 2 1 3 5 5 5 0 Runx inhibition domain DUF4988 PF16378.5 KPI86577.1 - 8.6 6.0 8.0 31 4.2 2.9 2.4 1 1 0 2 2 2 0 Domain of unknown function LSM PF01423.22 KPI86578.1 - 7e-14 51.3 0.1 9.5e-14 50.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain Zip PF02535.22 KPI86579.1 - 6.1e-36 124.3 10.2 2.8e-26 92.5 7.9 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Varsurf_PPLC PF03490.13 KPI86580.1 - 3e-13 49.5 0.7 7e-13 48.3 0.7 1.6 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C Coatomer_WDAD PF04053.14 KPI86581.1 - 3.4e-136 454.8 0.0 8e-136 453.6 0.0 1.6 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 KPI86581.1 - 2.1e-27 94.8 0.4 5.1e-07 30.3 0.0 6.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI86581.1 - 1.4e-08 34.9 0.0 0.026 14.8 0.0 5.3 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_12 PF13424.6 KPI86581.1 - 0.046 14.0 1.3 0.98 9.8 0.3 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.20 KPI86581.1 - 0.083 12.8 0.1 2.5 8.0 0.0 2.5 1 1 2 3 3 3 0 Region in Clathrin and VPS zf-RanBP PF00641.18 KPI86582.1 - 9.4e-18 63.2 34.6 8.4e-09 34.6 1.3 5.6 5 0 0 5 5 5 5 Zn-finger in Ran binding protein and others DZR PF12773.7 KPI86582.1 - 0.013 15.5 34.7 0.28 11.2 10.6 4.5 2 2 2 4 4 4 0 Double zinc ribbon Paired_CXXCH_1 PF09699.10 KPI86582.1 - 1.4 8.7 14.4 0.068 12.9 2.2 4.0 3 1 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) EF-hand_7 PF13499.6 KPI86584.1 - 1.7e-06 28.4 0.0 7.6e-05 23.1 0.0 3.1 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI86584.1 - 7.1e-05 22.4 0.0 0.0074 16.1 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KPI86584.1 - 0.0018 17.7 0.0 0.0044 16.5 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KPI86584.1 - 0.0024 17.3 0.0 0.036 13.6 0.0 2.7 2 0 0 2 2 2 1 EF hand Ribosomal_L44 PF00935.19 KPI86585.1 - 7.2e-32 109.7 8.9 1e-31 109.2 8.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 UPF0697 PF15117.6 KPI86587.1 - 0.047 13.8 0.6 0.047 13.8 0.6 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0697 ABC_tran PF00005.27 KPI86588.1 - 1.4e-20 74.2 0.0 2.3e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 KPI86588.1 - 0.012 15.4 0.1 0.027 14.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KPI86588.1 - 0.037 14.4 0.7 0.17 12.3 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 KPI86588.1 - 0.079 13.1 0.2 13 5.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2880 PF11082.8 KPI86588.1 - 0.14 12.5 0.4 1.8 9.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2880) AAA_23 PF13476.6 KPI86588.1 - 0.26 11.7 0.1 0.44 11.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain FA_desaturase PF00487.24 KPI86589.1 - 5.2e-25 88.7 28.8 5.2e-25 88.7 28.8 1.4 1 1 1 2 2 2 2 Fatty acid desaturase DUF1772 PF08592.11 KPI86590.1 - 5.9 7.2 18.5 0.63 10.4 4.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) PEPcase_2 PF14010.6 KPI86592.1 - 0.13 10.8 0.0 0.17 10.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase CD52 PF15116.6 KPI86592.1 - 0.85 9.7 6.3 3.3 7.8 6.3 2.0 1 0 0 1 1 1 0 CAMPATH-1 antigen HrcA PF01628.21 KPI86593.1 - 0.085 12.7 1.4 0.16 11.9 1.0 1.7 1 1 0 1 1 1 0 HrcA protein C terminal domain PEHE PF15275.6 KPI86593.1 - 0.78 10.4 0.1 0.78 10.4 0.1 2.9 2 1 0 2 2 2 0 PEHE domain Methyltransf_16 PF10294.9 KPI86594.1 - 2.7e-19 69.6 0.0 1.8e-14 53.9 0.0 2.4 2 0 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 KPI86594.1 - 0.037 13.6 0.0 0.093 12.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain Myb_DNA-binding PF00249.31 KPI86595.1 - 2.2e-19 69.4 1.3 4.3e-11 42.8 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KPI86595.1 - 1.8e-14 53.7 7.7 1.9e-08 34.4 0.4 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KPI86595.1 - 0.32 10.9 3.3 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Myb DNA-binding like IMPDH PF00478.25 KPI86597.1 - 3.7e-143 476.7 5.5 4.2e-143 476.5 5.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 KPI86597.1 - 2.7e-09 37.3 0.1 0.0035 17.7 0.0 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 KPI86597.1 - 4.4e-08 32.5 5.3 1e-07 31.3 5.3 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 KPI86597.1 - 3e-06 26.8 14.0 0.0026 17.2 7.1 3.1 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 KPI86597.1 - 0.00042 19.8 2.2 0.016 14.7 0.1 2.3 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 KPI86597.1 - 0.0012 18.3 7.2 0.0028 17.0 0.5 2.7 3 0 0 3 3 3 1 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 KPI86597.1 - 0.0022 17.3 4.9 0.024 13.9 0.5 2.3 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 KPI86597.1 - 0.0039 16.4 5.0 0.0058 15.8 4.5 1.4 1 1 0 1 1 1 1 Conserved region in glutamate synthase NanE PF04131.14 KPI86597.1 - 0.1 11.8 2.7 4.3 6.5 0.2 2.7 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase PcrB PF01884.17 KPI86597.1 - 0.67 9.4 7.3 3.9 6.9 0.1 3.7 2 1 2 4 4 4 0 PcrB family Lysine_decarbox PF03641.14 KPI86598.1 - 1.1e-29 103.2 0.1 1.8e-29 102.5 0.1 1.4 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 KPI86598.1 - 6.1e-12 45.4 0.5 1.2e-11 44.5 0.5 1.4 1 0 0 1 1 1 1 SLOG cluster4 family ABM PF03992.16 KPI86598.1 - 3.2e-10 40.0 0.0 6.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase LSDAT_prok PF18171.1 KPI86598.1 - 0.051 12.8 0.1 0.099 11.9 0.1 1.3 1 1 0 1 1 1 0 SLOG in TRPM, prokaryote Kinesin PF00225.23 KPI86599.1 - 2.3e-105 352.2 0.0 2.3e-105 352.2 0.0 3.0 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KPI86599.1 - 2.3e-24 86.0 0.0 2.3e-24 86.0 0.0 2.9 2 1 0 2 2 2 1 Microtubule binding Baculo_IE-1 PF05290.11 KPI86599.1 - 5.5 6.9 6.9 19 5.2 1.9 2.9 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) CK2S PF15011.6 KPI86600.1 - 0.064 13.2 2.1 0.17 11.8 2.1 1.6 1 0 0 1 1 1 0 Casein Kinase 2 substrate zf-C3Hc3H PF13891.6 KPI86600.1 - 0.11 12.8 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Potential DNA-binding domain Tropomyosin_1 PF12718.7 KPI86600.1 - 0.22 11.7 4.6 0.73 10.0 3.9 2.0 2 1 0 2 2 2 0 Tropomyosin like ATG16 PF08614.11 KPI86600.1 - 0.37 11.0 14.1 0.65 10.2 3.1 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MbeD_MobD PF04899.12 KPI86600.1 - 0.61 10.2 4.5 1.9 8.7 1.6 2.5 2 0 0 2 2 2 0 MbeD/MobD like SlyX PF04102.12 KPI86600.1 - 2.5 8.8 10.2 0.23 12.1 2.1 3.0 3 0 0 3 3 3 0 SlyX ERM PF00769.19 KPI86600.1 - 5 6.9 10.8 13 5.5 10.8 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family G-patch PF01585.23 KPI86601.1 - 7.5e-12 45.0 2.4 8.9e-12 44.7 0.5 2.1 2 1 1 3 3 3 1 G-patch domain G-patch_2 PF12656.7 KPI86601.1 - 0.0048 17.0 0.4 0.015 15.4 0.4 1.8 1 0 0 1 1 1 1 G-patch domain Cwf_Cwc_15 PF04889.12 KPI86601.1 - 0.052 13.3 17.0 0.072 12.8 17.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Presenilin PF01080.17 KPI86601.1 - 0.68 8.6 8.4 0.84 8.3 8.4 1.0 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 KPI86601.1 - 2.2 6.7 10.1 2.6 6.5 10.1 1.0 1 0 0 1 1 1 0 Macoilin family SAPS PF04499.15 KPI86601.1 - 4.3 6.0 7.5 4.7 5.9 7.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DTHCT PF08070.11 KPI86601.1 - 4.4 8.1 22.7 7.8 7.3 22.7 1.4 1 0 0 1 1 1 0 DTHCT (NUC029) region MAJIN PF15077.6 KPI86601.1 - 6.5 6.5 7.4 9.1 6.0 7.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Peroxin-3 PF04882.12 KPI86601.1 - 7.8 5.4 10.0 9.4 5.1 10.0 1.1 1 0 0 1 1 1 0 Peroxin-3 DNA_pol_phi PF04931.13 KPI86601.1 - 8.3 4.4 14.6 11 4.0 14.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DBR1 PF05011.13 KPI86603.1 - 5.2e-08 33.4 0.0 1.1e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 KPI86603.1 - 9.6e-06 26.2 0.3 1.7e-05 25.4 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ATP-synt_10 PF05176.14 KPI86604.1 - 0.00055 19.2 0.1 0.0022 17.3 0.0 1.9 2 0 0 2 2 2 1 ATP10 protein Axin_b-cat_bind PF08833.10 KPI86604.1 - 1.2 9.3 3.6 5.1 7.3 0.9 2.7 2 0 0 2 2 2 0 Axin beta-catenin binding domain DUF1935 PF09149.10 KPI86606.1 - 1.6e-34 118.4 0.1 2.9e-34 117.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) META PF03724.16 KPI86606.1 - 4.8e-20 71.5 0.1 1.5e-07 31.4 0.0 3.2 3 0 0 3 3 3 3 META domain META PF03724.16 KPI86608.1 - 1.2e-12 47.7 0.0 1.5e-12 47.5 0.0 1.0 1 0 0 1 1 1 1 META domain META PF03724.16 KPI86609.1 - 1e-11 44.7 0.0 1.2e-11 44.5 0.0 1.0 1 0 0 1 1 1 1 META domain LRR_6 PF13516.6 KPI86610.1 - 7.1e-14 50.6 7.1 0.021 14.8 0.1 6.4 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.7 KPI86610.1 - 1.3e-05 25.4 9.0 0.52 10.8 0.3 4.4 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI86610.1 - 0.00064 19.9 0.0 1e+02 4.1 0.0 5.7 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 KPI86610.1 - 0.0047 16.7 8.2 0.8 9.5 0.1 4.5 3 2 0 3 3 3 2 Leucine rich repeat Acyltransferase PF01553.21 KPI86611.1 - 4.9e-16 58.6 0.0 8.2e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 KPI86611.1 - 1.1e-07 31.9 0.2 9.3e-06 25.7 0.2 2.7 1 1 0 1 1 1 1 Acyltransferase C-terminus Phage_holin_3_6 PF07332.11 KPI86611.1 - 4.1 7.5 8.3 0.15 12.1 0.9 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Sec63 PF02889.16 KPI86612.1 - 4.7e-58 196.4 0.0 1.1e-54 185.3 0.0 2.7 3 0 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.29 KPI86612.1 - 5.6e-32 110.9 0.3 1.2e-24 87.0 0.4 3.6 2 1 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 KPI86612.1 - 1.6e-11 44.5 0.0 3.9e-10 40.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_PWI PF18149.1 KPI86612.1 - 1.6e-09 37.9 0.0 5e-09 36.3 0.0 1.9 1 0 0 1 1 1 1 N-terminal helicase PWI domain Helicase_C PF00271.31 KPI86612.1 - 1.8e-07 31.5 0.0 5.1e-06 26.8 0.0 2.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KPI86612.1 - 0.00011 22.4 0.6 0.4 10.9 0.1 4.5 5 0 0 5 5 5 1 AAA domain IstB_IS21 PF01695.17 KPI86612.1 - 0.12 12.1 0.0 25 4.6 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein DFF-C PF09033.10 KPI86612.1 - 1.7 8.6 6.0 4.4 7.2 0.1 3.4 3 0 0 3 3 3 0 DNA Fragmentation factor 45kDa, C terminal domain COPI_assoc PF08507.10 KPI86613.1 - 1.9e-08 34.4 16.4 2.4e-08 34.1 16.4 1.1 1 0 0 1 1 1 1 COPI associated protein DUF373 PF04123.13 KPI86613.1 - 9.2 5.6 8.5 12 5.3 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) COPI_assoc PF08507.10 KPI86614.1 - 1.9e-07 31.2 7.7 2.4e-07 30.8 7.7 1.1 1 0 0 1 1 1 1 COPI associated protein Clc-like PF07062.12 KPI86614.1 - 0.083 12.4 7.4 0.11 12.0 7.4 1.1 1 0 0 1 1 1 0 Clc-like DUF4748 PF15932.5 KPI86614.1 - 0.56 10.0 0.1 0.56 10.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) DUF5527 PF17665.1 KPI86614.1 - 0.95 9.0 3.1 0.32 10.5 0.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5527) PsbT PF01405.17 KPI86614.1 - 0.96 9.3 3.8 0.38 10.6 0.4 2.2 2 0 0 2 2 2 0 Photosystem II reaction centre T protein DUF3784 PF12650.7 KPI86614.1 - 1.5 9.1 10.5 0.79 10.0 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF2721 PF11026.8 KPI86614.1 - 3.3 7.6 14.2 0.1 12.5 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) DUF4191 PF13829.6 KPI86614.1 - 7 5.9 7.9 0.77 9.1 2.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) Abhydrolase_1 PF00561.20 KPI86615.1 - 2.9e-08 33.7 0.0 0.00015 21.6 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI86615.1 - 5.1e-06 25.9 0.0 1.9e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI86616.1 - 6.1e-06 26.1 0.1 0.017 14.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI86616.1 - 1.7e-05 24.2 0.0 9.1e-05 21.8 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI86616.1 - 6.3e-05 23.7 0.0 0.00014 22.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Taxilin PF09728.9 KPI86616.1 - 0.015 14.5 0.2 0.023 13.9 0.2 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Glyco_trans_4_2 PF13477.6 KPI86616.1 - 0.11 12.5 0.0 3.8 7.6 0.0 2.9 2 1 1 3 3 3 0 Glycosyl transferase 4-like PHO4 PF01384.20 KPI86617.1 - 0.077 12.0 0.2 0.078 12.0 0.2 1.0 1 0 0 1 1 1 0 Phosphate transporter family Nuc_rec_co-act PF08815.10 KPI86617.1 - 0.2 11.6 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Nuclear receptor coactivator ArfGap PF01412.18 KPI86618.1 - 2.7e-25 88.7 0.2 7.8e-25 87.2 0.2 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ribosomal_L7Ae PF01248.26 KPI86620.1 - 2.9e-24 84.6 0.0 3.2e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family IF3_N PF05198.16 KPI86620.1 - 0.038 14.3 0.0 0.061 13.6 0.0 1.2 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain DUF3085 PF11284.8 KPI86620.1 - 0.098 13.0 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3085) DnaJ PF00226.31 KPI86621.1 - 0.0014 18.7 0.0 0.0077 16.3 0.0 2.1 1 1 0 1 1 1 1 DnaJ domain zf_CCCH_4 PF18345.1 KPI86621.1 - 0.0017 18.4 3.5 0.0017 18.4 3.5 2.3 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH PF00642.24 KPI86621.1 - 0.0037 17.1 4.9 0.0072 16.2 4.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KPI86621.1 - 0.0076 16.9 1.1 0.028 15.1 1.1 1.9 1 0 0 1 1 1 1 Torus domain PyocinActivator PF11112.8 KPI86621.1 - 0.16 12.1 0.0 2.8 8.1 0.0 2.4 2 0 0 2 2 2 0 Pyocin activator protein PrtN Nab2p_Zf1 PF18260.1 KPI86621.1 - 0.17 11.8 1.6 0.35 10.8 1.6 1.5 1 0 0 1 1 1 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf-CCCH_4 PF18044.1 KPI86621.1 - 5.1 7.0 13.2 0.055 13.3 4.3 2.1 2 0 0 2 2 2 0 CCCH-type zinc finger ERM PF00769.19 KPI86623.1 - 0.0043 16.9 18.6 0.0043 16.9 18.6 14.2 8 4 3 12 12 12 3 Ezrin/radixin/moesin family ATG16 PF08614.11 KPI86623.1 - 0.0045 17.2 9.6 0.0045 17.2 9.6 18.9 6 6 7 17 17 17 6 Autophagy protein 16 (ATG16) EMP24_GP25L PF01105.24 KPI86623.1 - 0.023 14.6 0.2 0.023 14.6 0.2 11.4 14 3 1 15 15 15 0 emp24/gp25L/p24 family/GOLD NIF PF03031.18 KPI86624.1 - 2.5e-31 108.6 0.0 3.4e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.26 KPI86624.1 - 0.00035 20.9 0.0 0.00045 20.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI86624.1 - 0.00038 20.9 0.1 0.0017 18.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Phage_mat-A PF03863.13 KPI86625.1 - 0.11 11.4 0.2 0.2 10.5 0.2 1.4 1 0 0 1 1 1 0 Phage maturation protein DUF2680 PF10925.8 KPI86625.1 - 1.7 8.7 5.4 32 4.6 0.3 4.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2680) Noelin-1 PF12308.8 KPI86625.1 - 6.6 6.8 20.8 1.6 8.7 0.7 5.9 3 2 1 4 4 4 0 Neurogenesis glycoprotein Mito_carr PF00153.27 KPI86628.1 - 1.5e-05 24.9 0.4 0.1 12.5 0.1 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein Arf PF00025.21 KPI86630.1 - 1.1e-61 207.3 0.0 1.2e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI86630.1 - 3.7e-13 49.7 0.0 5e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KPI86630.1 - 9.4e-12 44.7 0.9 1.2e-09 37.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KPI86630.1 - 4.3e-11 42.6 0.0 5.1e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 KPI86630.1 - 2.8e-10 40.0 0.0 3.3e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KPI86630.1 - 5e-08 32.6 0.0 6.1e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KPI86630.1 - 3e-06 27.3 0.0 4.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI86630.1 - 1.4e-05 24.7 0.0 3.3e-05 23.5 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KPI86630.1 - 0.018 14.6 0.0 0.053 13.0 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B LMBR1 PF04791.16 KPI86631.1 - 2.9e-17 62.8 31.7 1.6e-12 47.2 7.8 2.1 1 1 1 2 2 2 2 LMBR1-like membrane protein V_ATPase_I PF01496.19 KPI86631.1 - 1.7 6.5 8.8 2.8 5.7 8.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Clat_adaptor_s PF01217.20 KPI86632.1 - 3.3e-13 49.8 0.1 4.8e-13 49.3 0.1 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_tranf_2_3 PF13641.6 KPI86632.1 - 0.091 12.6 0.4 0.15 12.0 0.4 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 OSR1_C PF12202.8 KPI86632.1 - 0.1 12.8 0.1 0.31 11.3 0.1 1.8 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain MAT1-1-2 PF17043.5 KPI86632.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Mating type protein 1-1-2 of unknown function UCR_14kD PF02271.16 KPI86633.1 - 1.2e-07 31.6 0.1 5.8e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase complex 14kD subunit TrkH PF02386.16 KPI86635.1 - 1.6e-09 36.7 16.1 6.7e-08 31.4 1.5 2.9 2 2 0 2 2 2 2 Cation transport protein Sigma_reg_N PF13800.6 KPI86635.1 - 0.22 11.8 1.2 0.96 9.8 0.5 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Band_7 PF01145.25 KPI86636.1 - 7.6e-25 87.9 0.7 1.2e-24 87.3 0.7 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF4632 PF15451.6 KPI86638.1 - 0.0021 18.1 0.9 0.0052 16.8 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4632) Transket_pyr PF02779.24 KPI86639.1 - 6.4e-38 130.2 0.0 1.3e-37 129.2 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KPI86639.1 - 3.2e-35 120.7 0.0 6.3e-35 119.8 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 KPI86639.1 - 9e-05 22.7 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II PI-PLC-X PF00388.19 KPI86640.1 - 2.6e-58 195.7 0.0 4e-58 195.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KPI86640.1 - 5.6e-34 116.9 0.0 1.2e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_1 PF00036.32 KPI86640.1 - 0.0006 19.2 3.1 0.00093 18.6 1.7 2.1 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 KPI86640.1 - 0.0038 17.1 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 KPI86640.1 - 0.019 15.4 0.1 0.051 14.0 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KPI86640.1 - 0.057 13.4 3.5 0.18 11.8 3.5 1.9 1 0 0 1 1 1 0 EF-hand domain PK PF00224.21 KPI86641.1 - 1.2e-153 511.1 0.6 1.5e-153 510.8 0.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KPI86641.1 - 2.5e-26 92.2 0.4 1e-25 90.3 0.1 2.2 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KPI86641.1 - 0.001 18.2 0.4 0.0031 16.7 0.4 1.7 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family RTP1_C1 PF10363.9 KPI86641.1 - 0.022 14.9 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3479 PF11965.8 KPI86641.1 - 0.16 12.0 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) B12-binding PF02310.19 KPI86642.1 - 0.098 12.7 0.1 0.25 11.4 0.0 1.6 1 1 0 1 1 1 0 B12 binding domain PfkB PF00294.24 KPI86643.1 - 6.9e-34 117.5 0.0 8.8e-34 117.2 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Peptidase_M24 PF00557.24 KPI86644.1 - 2.5e-42 144.9 0.0 4.4e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 KPI86644.1 - 1.4e-40 139.0 0.1 7.8e-40 136.6 0.0 2.0 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 KPI86644.1 - 4.7e-19 69.4 0.1 2.4e-13 50.9 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 KPI86644.1 - 1.6e-18 66.5 0.0 6.3e-18 64.6 0.0 2.1 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Gemini_AL1_M PF08283.11 KPI86644.1 - 0.16 12.1 0.0 0.47 10.6 0.0 1.8 2 0 0 2 2 2 0 Geminivirus rep protein central domain PH_12 PF16457.5 KPI86646.1 - 3.1e-05 24.5 0.4 0.00024 21.7 0.0 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Arv1 PF04161.13 KPI86647.1 - 3.4e-28 99.2 5.0 5.1e-28 98.7 5.0 1.3 1 0 0 1 1 1 1 Arv1-like family DZR PF12773.7 KPI86647.1 - 0.36 10.9 2.5 0.61 10.2 2.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.6 KPI86647.1 - 0.69 9.9 5.3 1.4 8.9 5.3 1.5 1 0 0 1 1 1 0 Nudix N-terminal GSP_synth PF03738.14 KPI86648.1 - 3.5e-48 164.7 0.0 1.4e-38 133.1 0.0 2.1 2 0 0 2 2 2 2 Glutathionylspermidine synthase preATP-grasp CHAP PF05257.16 KPI86648.1 - 3.2e-13 50.1 0.1 9.4e-13 48.6 0.1 1.9 2 0 0 2 2 2 1 CHAP domain DUF2627 PF11118.8 KPI86649.1 - 0.081 13.5 0.0 0.082 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) ADK PF00406.22 KPI86651.1 - 6.7e-35 120.4 0.0 8e-35 120.2 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KPI86651.1 - 7.5e-16 58.8 0.0 1.1e-15 58.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KPI86651.1 - 4.1e-12 45.9 0.6 6.6e-12 45.2 0.6 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid A2L_zn_ribbon PF08792.10 KPI86651.1 - 0.00095 18.8 0.2 0.15 11.8 0.0 2.4 2 0 0 2 2 2 1 A2L zinc ribbon domain AAA_33 PF13671.6 KPI86651.1 - 0.001 19.2 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain YadA_anchor PF03895.15 KPI86651.1 - 0.0016 18.5 0.2 0.0028 17.7 0.2 1.3 1 0 0 1 1 1 1 YadA-like membrane anchor domain zf-C2H2_3 PF13878.6 KPI86651.1 - 0.031 14.1 2.2 0.036 13.9 0.1 1.9 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO AAA_18 PF13238.6 KPI86651.1 - 0.035 14.6 0.0 0.051 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain TF_Zn_Ribbon PF08271.12 KPI86651.1 - 0.053 13.1 2.3 1.5 8.4 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding UPF0547 PF10571.9 KPI86651.1 - 0.16 12.1 0.2 0.16 12.1 0.2 1.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Nudix_N_2 PF14803.6 KPI86651.1 - 0.32 10.9 3.3 15 5.6 0.1 3.2 3 0 0 3 3 3 0 Nudix N-terminal zf-ribbon_3 PF13248.6 KPI86651.1 - 0.39 10.2 2.5 9.1 5.9 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-RanBP PF00641.18 KPI86651.1 - 0.68 9.3 2.4 6.7 6.1 0.2 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Pkinase PF00069.25 KPI86654.1 - 3e-65 220.2 0.0 4e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86654.1 - 2e-38 132.2 0.0 2.6e-38 131.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI86654.1 - 3.5e-06 26.5 0.0 6.3e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI86654.1 - 0.024 14.6 0.0 0.47 10.3 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KPI86654.1 - 0.038 13.3 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VPS9 PF02204.18 KPI86655.1 - 9e-13 48.3 0.0 1.5e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain MORN PF02493.20 KPI86655.1 - 1.9e-07 30.6 19.4 3.2e-06 26.7 1.2 6.0 6 0 0 6 6 6 2 MORN repeat SPC12 PF06645.13 KPI86656.1 - 6e-06 26.3 1.9 1e-05 25.5 1.9 1.3 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) PRA1 PF03208.19 KPI86656.1 - 0.06 13.0 0.4 0.086 12.5 0.4 1.2 1 0 0 1 1 1 0 PRA1 family protein LRR_8 PF13855.6 KPI86658.1 - 1.7e-08 34.1 9.3 2.2e-05 24.1 1.2 2.5 2 1 1 3 3 3 2 Leucine rich repeat EF-hand_7 PF13499.6 KPI86658.1 - 1.8e-05 25.1 0.0 0.00011 22.5 0.0 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI86658.1 - 0.00037 19.8 0.0 0.026 14.0 0.0 3.7 4 0 0 4 4 4 1 EF hand LRR_4 PF12799.7 KPI86658.1 - 0.00066 20.0 5.7 0.0042 17.5 0.6 2.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) EF-hand_6 PF13405.6 KPI86658.1 - 0.0016 18.2 0.0 0.019 14.8 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KPI86658.1 - 0.013 15.4 0.5 0.48 10.3 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain pair LRR_1 PF00560.33 KPI86658.1 - 0.5 11.1 2.5 44 5.2 0.2 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat Pex2_Pex12 PF04757.14 KPI86659.1 - 5.2e-10 39.3 0.4 2.5e-07 30.5 0.4 2.1 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 KPI86659.1 - 3.1e-09 37.0 12.6 6e-09 36.1 12.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KPI86659.1 - 8.3e-09 35.2 10.4 1.4e-08 34.5 10.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI86659.1 - 2.1e-07 30.8 9.8 4.7e-07 29.7 9.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KPI86659.1 - 1.7e-06 27.8 10.9 3.3e-06 26.9 10.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KPI86659.1 - 4.6e-06 26.4 11.8 8.6e-06 25.5 11.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KPI86659.1 - 8.9e-06 25.9 8.3 1.8e-05 24.9 8.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KPI86659.1 - 3.8e-05 23.7 11.5 3.8e-05 23.7 11.5 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 KPI86659.1 - 5.5e-05 23.1 7.0 9.9e-05 22.3 7.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 KPI86659.1 - 0.00011 22.0 12.1 0.0002 21.1 12.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI86659.1 - 0.00011 22.1 8.3 0.00013 21.9 6.0 2.3 1 1 1 2 2 2 1 RING-type zinc-finger U-box PF04564.15 KPI86659.1 - 0.074 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 U-box domain zf-Nse PF11789.8 KPI86659.1 - 0.4 10.5 4.2 0.89 9.4 4.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 KPI86659.1 - 2.3 8.1 10.0 6 6.7 10.0 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.21 KPI86659.1 - 4 7.7 10.5 14 6.0 10.5 1.9 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain DHHC PF01529.20 KPI86660.1 - 2.6e-32 111.7 3.6 2.6e-32 111.7 3.6 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF898 PF05987.13 KPI86660.1 - 0.0099 15.0 1.0 0.0099 15.0 1.0 1.5 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF898) QueC PF06508.13 KPI86660.1 - 1.3 8.4 4.3 2.6 7.5 4.3 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC PHD PF00628.29 KPI86665.1 - 1.1e-05 25.2 8.1 1.1e-05 25.2 8.1 2.4 2 0 0 2 2 2 2 PHD-finger PHD_4 PF16866.5 KPI86665.1 - 4.1 7.6 10.4 21 5.3 10.4 2.1 1 1 0 1 1 1 0 PHD-finger Pex2_Pex12 PF04757.14 KPI86666.1 - 3.7e-31 108.5 11.0 4.4e-31 108.2 11.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 KPI86666.1 - 0.017 15.0 14.5 0.032 14.1 14.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI86666.1 - 0.17 12.1 12.3 0.55 10.4 12.2 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KPI86666.1 - 1.5 8.8 17.0 2.4 8.1 17.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI86666.1 - 5.1 7.2 12.3 0.4 10.7 6.4 2.1 1 1 1 2 2 2 0 RING-type zinc-finger Slp PF03843.13 KPI86667.1 - 0.0073 15.7 0.0 0.025 14.0 0.0 1.9 2 0 0 2 2 2 1 Outer membrane lipoprotein Slp family Fib_alpha PF08702.10 KPI86667.1 - 0.062 13.5 1.6 0.22 11.7 0.4 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF913 PF06025.12 KPI86667.1 - 0.11 11.4 1.6 0.73 8.7 0.0 2.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Cytochrom_B562 PF07361.11 KPI86667.1 - 0.16 12.7 1.7 5.4 7.7 0.1 3.2 2 1 1 3 3 3 0 Cytochrome b562 T2SSF PF00482.23 KPI86667.1 - 0.67 9.9 2.7 5.9 6.9 0.5 3.5 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F PCI PF01399.27 KPI86668.1 - 1.5e-07 31.9 0.0 4.3e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 PCI domain TPR_12 PF13424.6 KPI86668.1 - 0.0054 17.0 7.7 0.46 10.8 0.4 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SnoaL_3 PF13474.6 KPI86668.1 - 0.015 15.5 0.5 5.3 7.3 0.1 2.7 2 0 0 2 2 2 0 SnoaL-like domain Rapsyn_N PF10579.9 KPI86668.1 - 0.05 13.7 0.4 0.29 11.3 0.2 2.3 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region TPR_2 PF07719.17 KPI86668.1 - 0.14 12.4 6.0 13 6.2 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI86668.1 - 1.3 9.2 6.9 5.2 7.3 0.2 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat ParcG PF10274.9 KPI86669.1 - 3.2e-75 252.3 0.0 3.9e-75 252.0 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein DCB PF16213.5 KPI86669.1 - 0.059 13.0 0.0 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 DnaJ PF00226.31 KPI86670.1 - 2.5e-24 85.2 4.3 6.3e-24 83.9 4.3 1.7 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 KPI86670.1 - 5.2e-10 39.3 7.3 1e-09 38.4 7.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KPI86670.1 - 4.9e-08 33.1 3.0 9e-08 32.3 3.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KPI86670.1 - 0.0001 22.6 0.7 0.00027 21.2 0.4 1.9 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 KPI86670.1 - 0.0081 16.4 0.2 0.023 14.9 0.2 1.8 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.26 KPI86670.1 - 0.011 16.1 1.4 0.025 15.0 1.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF4136 PF13590.6 KPI86670.1 - 0.012 16.2 1.7 0.028 15.0 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4136) zf-C2H2_4 PF13894.6 KPI86670.1 - 0.013 16.3 1.4 0.034 15.0 0.4 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger ABATE PF07336.11 KPI86670.1 - 0.022 15.4 4.3 0.043 14.5 4.3 1.5 1 0 0 1 1 1 0 Putative stress-induced transcription regulator OPA3 PF07047.12 KPI86670.1 - 9.8 6.0 8.4 5.8 6.7 4.6 2.2 1 1 1 2 2 2 0 Optic atrophy 3 protein (OPA3) Sec1 PF00995.23 KPI86671.1 - 1.3e-89 302.0 0.0 1.6e-89 301.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family CLP1_P PF16575.5 KPI86672.1 - 5.3e-16 59.0 0.0 1.9e-15 57.2 0.0 1.9 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Glyco_tranf_2_5 PF13712.6 KPI86672.1 - 0.045 13.4 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family Orn_DAP_Arg_deC PF00278.22 KPI86672.1 - 0.08 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Rad60-SLD PF11976.8 KPI86673.1 - 6.4e-06 25.9 0.1 1e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KPI86673.1 - 2.8e-05 23.8 0.0 4.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF1515 PF07439.11 KPI86674.1 - 0.042 13.9 1.6 6.9 6.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) RSS_P20 PF11757.8 KPI86674.1 - 0.043 14.2 1.2 0.1 13.1 1.2 1.6 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain BRO1 PF03097.18 KPI86675.1 - 9.1e-18 64.2 0.5 1e-17 64.0 0.5 1.1 1 0 0 1 1 1 1 BRO1-like domain DSPc PF00782.20 KPI86676.1 - 1.9e-29 102.1 0.0 3.3e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI86676.1 - 0.03 13.9 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase MMR_HSR1 PF01926.23 KPI86678.1 - 4.1e-15 55.9 0.0 5.7e-14 52.2 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI86678.1 - 1.7e-06 27.6 0.0 5.3e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 KPI86678.1 - 0.00019 20.8 0.0 0.00038 19.9 0.0 1.5 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 KPI86678.1 - 0.00087 19.2 0.0 0.92 9.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KPI86678.1 - 2 8.8 4.6 1.2 9.5 0.0 2.9 2 1 1 3 3 3 0 AAA ATPase domain Fip1 PF05182.13 KPI86679.1 - 8.4e-19 66.8 0.2 1.5e-18 66.1 0.2 1.3 1 0 0 1 1 1 1 Fip1 motif zf-CCCH PF00642.24 KPI86679.1 - 1.4e-08 34.4 2.4 2.7e-08 33.5 2.4 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI86679.1 - 6.2e-05 22.9 4.4 0.00011 22.1 4.4 1.4 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 KPI86679.1 - 0.00025 21.7 0.8 0.00051 20.7 0.8 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 KPI86679.1 - 0.00033 20.4 3.5 0.00056 19.6 3.5 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger 2-oxoacid_dh PF00198.23 KPI86680.1 - 6.6e-76 254.8 0.0 8.7e-76 254.4 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KPI86680.1 - 2.9e-38 129.5 6.5 1.1e-18 66.9 1.1 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme E3_binding PF02817.17 KPI86680.1 - 2.1e-16 59.9 0.1 6.3e-16 58.4 0.1 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 KPI86680.1 - 7.8e-06 25.6 7.7 0.0082 15.9 0.4 3.6 4 0 0 4 4 4 2 Biotin-lipoyl like HlyD_D23 PF16576.5 KPI86680.1 - 0.00039 19.7 0.3 0.34 10.1 0.0 2.6 2 0 0 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 KPI86680.1 - 0.0086 16.8 3.5 1.2 9.8 0.2 3.0 2 1 0 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 KPI86680.1 - 0.029 14.3 3.3 4.9 7.1 0.3 2.8 3 0 0 3 3 3 0 Glycine cleavage H-protein DUF1627 PF07789.12 KPI86680.1 - 0.81 9.3 8.3 0.17 11.5 0.9 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1627) Spc7 PF08317.11 KPI86682.1 - 0.00039 19.4 10.3 0.00039 19.4 10.3 4.1 2 2 2 4 4 4 1 Spc7 kinetochore protein GOLGA2L5 PF15070.6 KPI86682.1 - 0.00089 18.0 7.8 0.00089 18.0 7.8 3.7 2 2 1 3 3 3 1 Putative golgin subfamily A member 2-like protein 5 FPP PF05911.11 KPI86682.1 - 0.0011 17.3 17.6 0.0011 17.3 17.6 2.3 2 0 0 2 2 2 1 Filament-like plant protein, long coiled-coil zf-C4H2 PF10146.9 KPI86682.1 - 0.0021 18.4 31.3 0.014 15.7 10.0 2.6 2 1 0 2 2 2 2 Zinc finger-containing protein Lebercilin PF15619.6 KPI86682.1 - 0.0025 17.5 19.1 0.0025 17.5 19.1 3.5 2 1 1 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 KPI86682.1 - 0.0049 17.1 35.3 0.013 15.7 6.2 3.6 2 2 1 3 3 3 2 Fibrinogen alpha/beta chain family Fez1 PF06818.15 KPI86682.1 - 0.012 16.1 59.6 0.79 10.1 19.6 3.7 1 1 2 3 3 3 0 Fez1 DUF3584 PF12128.8 KPI86682.1 - 0.5 7.8 57.5 0.066 10.7 29.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) LRR_6 PF13516.6 KPI86683.1 - 1.6e-35 118.1 21.2 2.3e-05 24.1 0.2 10.8 11 0 0 11 11 11 9 Leucine Rich repeat LRR_1 PF00560.33 KPI86683.1 - 1.1e-10 40.5 0.0 5.4 8.0 0.0 7.3 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_4 PF12799.7 KPI86683.1 - 1.3e-10 41.3 8.2 0.00076 19.8 0.1 4.9 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) Peripla_BP_1 PF00532.21 KPI86683.1 - 0.079 12.4 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family LRR_8 PF13855.6 KPI86683.1 - 0.25 11.1 17.9 0.89 9.4 0.8 5.6 5 2 1 6 6 6 0 Leucine rich repeat DEAD PF00270.29 KPI86684.1 - 2.8e-41 141.2 0.0 5e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI86684.1 - 6.2e-32 110.3 0.0 4.3e-29 101.1 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain GUCT PF08152.12 KPI86684.1 - 5.5e-19 68.3 0.0 1.6e-18 66.8 0.0 1.9 2 0 0 2 2 2 1 GUCT (NUC152) domain ERCC3_RAD25_C PF16203.5 KPI86684.1 - 7.7e-05 22.0 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 KPI86684.1 - 0.0093 16.0 0.0 0.03 14.3 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Pkinase PF00069.25 KPI86685.1 - 3.8e-52 177.2 0.0 8e-52 176.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86685.1 - 1.6e-25 89.9 0.2 6e-23 81.4 0.3 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KPI86685.1 - 6.5e-05 22.4 0.3 0.0001 21.7 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI86685.1 - 0.00011 22.2 0.1 0.00093 19.2 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI86685.1 - 0.00074 18.4 0.0 0.00099 18.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KPI86685.1 - 0.0029 17.1 0.2 0.0045 16.5 0.2 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 KPI86685.1 - 0.025 13.5 0.2 0.035 13.1 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 KPI86685.1 - 0.053 13.1 0.5 0.085 12.5 0.5 1.3 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 KPI86685.1 - 0.096 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase HD PF01966.22 KPI86685.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 HD domain Methyltransf_4 PF02390.17 KPI86686.1 - 0.0023 17.4 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Metallophos PF00149.28 KPI86688.1 - 2.4e-26 93.5 0.1 3.9e-26 92.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Plus-3 PF03126.18 KPI86688.1 - 6.5e-06 26.6 0.0 1.3e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Plus-3 domain NUDIX PF00293.28 KPI86689.1 - 5.8e-15 55.5 0.0 8.3e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Rrp15p PF07890.12 KPI86690.1 - 5.3e-10 39.8 9.4 1.2e-09 38.6 9.4 1.6 1 1 0 1 1 1 1 Rrp15p Dynein_light PF01221.18 KPI86691.1 - 6.6e-28 96.9 0.7 7.9e-28 96.6 0.7 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 Vasohibin PF14822.6 KPI86691.1 - 0.0037 16.5 0.1 0.0044 16.3 0.1 1.3 1 1 0 1 1 1 1 Vasohibin MVP_shoulder PF11978.8 KPI86692.1 - 3.8e-48 162.4 0.2 7.7e-48 161.4 0.2 1.5 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.18 KPI86692.1 - 2e-44 149.5 1.7 5.1e-11 42.6 0.0 5.0 5 0 0 5 5 5 4 Major Vault Protein repeat domain Vault_3 PF17795.1 KPI86692.1 - 2.7e-32 110.6 3.0 3e-30 104.0 0.1 3.4 3 0 0 3 3 3 2 Major Vault Protein Repeat domain Vault_2 PF17794.1 KPI86692.1 - 8.7e-26 90.1 0.1 7.2e-18 64.7 0.0 3.1 2 0 0 2 2 2 2 Major Vault Protein repeat domain Vault_4 PF17796.1 KPI86692.1 - 1e-19 70.3 0.3 4.1e-18 65.2 0.2 3.1 3 0 0 3 3 3 1 Major Vault Protein repeat domain DUF3601 PF12208.8 KPI86692.1 - 0.0026 17.8 0.0 11 6.2 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF3601) Transglut_prok PF09017.10 KPI86693.1 - 0.072 12.4 2.5 0.12 11.7 2.5 1.3 1 0 0 1 1 1 0 Microbial transglutaminase PNK3P PF08645.11 KPI86693.1 - 0.54 9.9 2.6 1.4 8.6 2.6 1.7 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase DUF771 PF05595.11 KPI86694.1 - 2.7 8.0 5.6 8.4 6.4 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF771) Arf PF00025.21 KPI86695.1 - 5.1e-53 179.1 0.0 5.8e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI86695.1 - 7.4e-08 32.5 0.0 1.4e-07 31.6 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 KPI86695.1 - 8e-08 31.8 0.8 8.5e-05 21.9 0.1 2.7 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KPI86695.1 - 5.1e-07 29.3 0.0 6.6e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KPI86695.1 - 9.6e-07 29.0 0.0 2.3e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI86695.1 - 5.6e-06 26.0 0.0 6.9e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 KPI86695.1 - 4.5e-05 23.1 0.1 0.015 14.8 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KPI86695.1 - 0.0015 17.9 0.0 0.002 17.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 KPI86695.1 - 0.0071 15.9 0.0 0.52 9.9 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 KPI86695.1 - 0.056 13.0 0.1 0.32 10.5 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B SRP54 PF00448.22 KPI86695.1 - 0.08 12.6 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF2072 PF09845.9 KPI86696.1 - 0.061 13.6 0.0 0.069 13.4 0.0 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein zf-C3HC4_5 PF17121.5 KPI86696.1 - 0.14 12.1 2.7 0.37 10.7 2.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TMF_TATA_bd PF12325.8 KPI86697.1 - 0.0018 18.5 2.7 0.0018 18.5 2.7 10.1 3 3 6 10 10 10 2 TATA element modulatory factor 1 TATA binding MscS_porin PF12795.7 KPI86697.1 - 0.0042 16.7 17.9 0.0042 16.7 17.9 6.5 4 3 0 5 5 5 1 Mechanosensitive ion channel porin domain MS_channel PF00924.18 KPI86697.1 - 2.9 7.4 4.4 3.9 7.0 0.3 2.9 2 1 1 3 3 3 0 Mechanosensitive ion channel MotB_plug PF13677.6 KPI86698.1 - 0.093 12.3 0.2 0.093 12.3 0.2 2.8 3 0 0 3 3 3 0 Membrane MotB of proton-channel complex MotA/MotB SLATT_5 PF18160.1 KPI86698.1 - 0.19 11.1 1.7 0.4 10.0 1.7 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 FtsX PF02687.21 KPI86698.1 - 1.8 9.1 8.1 3.4 8.2 2.0 2.4 2 0 0 2 2 2 0 FtsX-like permease family ARD PF03079.14 KPI86700.1 - 6.4e-37 127.2 0.0 1.6e-36 125.9 0.0 1.6 2 0 0 2 2 2 1 ARD/ARD' family DUF953 PF06110.11 KPI86700.1 - 8e-14 51.3 0.0 1.3e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Cupin_2 PF07883.11 KPI86700.1 - 2.2e-09 36.9 0.0 4.2e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 KPI86700.1 - 4.1e-06 26.7 0.0 7.9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 KPI86700.1 - 0.044 13.4 0.0 0.083 12.5 0.0 1.4 1 0 0 1 1 1 0 Cupin Cupin_7 PF12973.7 KPI86700.1 - 0.073 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 ChrR Cupin-like domain Pkinase PF00069.25 KPI86701.1 - 7.3e-51 173.1 0.1 9.7e-35 120.2 0.1 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86701.1 - 7.9e-31 107.3 0.0 2e-30 106.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI86701.1 - 3.5e-05 22.8 0.1 0.00012 20.9 0.1 1.9 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KPI86701.1 - 0.0014 18.0 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI86701.1 - 0.092 12.1 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KPI86702.1 - 2.1e-56 191.2 0.0 2.9e-56 190.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86702.1 - 2.4e-24 86.0 0.0 3.8e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI86702.1 - 1.5e-09 37.6 0.0 2.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI86702.1 - 0.0054 16.7 0.1 0.044 13.7 0.0 2.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family 3HCDH PF00725.22 KPI86702.1 - 0.12 13.0 0.0 0.3 11.7 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Pkinase_fungal PF17667.1 KPI86702.1 - 0.23 10.2 0.0 0.42 9.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF4379 PF14311.6 KPI86703.1 - 1.5e-19 70.1 6.9 3.5e-12 46.5 4.1 2.7 2 0 0 2 2 2 2 Probable Zinc-ribbon domain Zn-ribbon_8 PF09723.10 KPI86703.1 - 0.65 10.2 2.9 1.4 9.1 2.9 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 KPI86703.1 - 1.3 9.0 8.3 3.1 7.8 8.3 1.6 1 0 0 1 1 1 0 SprT-like zinc ribbon domain BUD22 PF09073.10 KPI86705.1 - 0.0035 16.7 23.9 0.0064 15.9 23.9 1.4 1 0 0 1 1 1 1 BUD22 rRNA_processing PF08524.11 KPI86705.1 - 2.9 7.9 6.9 7.3 6.6 6.9 1.6 1 0 0 1 1 1 0 rRNA processing AATF-Che1 PF13339.6 KPI86706.1 - 1.6e-12 48.3 0.0 1.6e-12 48.3 0.0 2.7 3 0 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 KPI86706.1 - 0.00094 19.6 0.0 0.004 17.6 0.0 2.1 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal DUF2052 PF09747.9 KPI86707.1 - 0.61 10.2 14.3 1.8 8.6 14.3 1.8 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SOBP PF15279.6 KPI86707.1 - 1.6 9.3 8.2 2 8.9 8.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 KPI86707.1 - 3.1 6.5 10.2 4 6.1 10.2 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 KPI86707.1 - 4.4 5.7 11.1 5.3 5.5 11.1 1.1 1 0 0 1 1 1 0 Macoilin family Ribonuclease_3 PF00636.26 KPI86708.1 - 1.7e-07 31.8 0.0 9.3e-07 29.4 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain Elf1 PF05129.13 KPI86709.1 - 1.2e-12 47.7 0.0 1.7e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Elf1 PF05129.13 KPI86710.1 - 3e-19 68.9 0.2 7.1e-19 67.6 0.5 1.5 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 KPI86710.1 - 0.032 14.6 0.1 0.075 13.4 0.1 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 KPI86710.1 - 0.12 12.5 0.2 0.26 11.4 0.2 1.5 1 0 0 1 1 1 0 Zinc ribbon domain DEAD PF00270.29 KPI86711.1 - 7.3e-30 104.0 0.2 3.5e-16 59.5 0.1 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI86711.1 - 5.4e-16 58.9 0.0 1.8e-15 57.3 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI86711.1 - 6.9e-08 32.7 0.0 4.3e-07 30.1 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KPI86711.1 - 0.031 14.6 0.4 8.9 6.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KPI86711.1 - 0.11 11.9 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial TniB protein FAM176 PF14851.6 KPI86711.1 - 0.12 12.1 2.4 9.1 5.9 0.1 3.1 3 0 0 3 3 3 0 FAM176 family DUF4611 PF15387.6 KPI86711.1 - 1.3 9.3 7.0 7.1 6.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) TruD PF01142.18 KPI86713.1 - 1.2e-08 34.3 0.0 3.5e-05 22.8 0.0 3.3 4 0 0 4 4 4 2 tRNA pseudouridine synthase D (TruD) SCO1-SenC PF02630.14 KPI86714.1 - 1.9e-29 102.3 0.2 1e-27 96.7 0.2 2.2 1 1 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 KPI86714.1 - 0.011 16.0 0.0 0.023 15.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like ACPS PF01648.20 KPI86715.1 - 2.5e-13 50.1 0.0 4.5e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily AAA PF00004.29 KPI86717.1 - 4.5e-50 169.5 0.0 5.8e-37 127.1 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI86717.1 - 4.4e-10 39.2 0.0 1.2e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KPI86717.1 - 2.8e-09 37.4 1.0 0.018 15.3 0.6 4.5 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 KPI86717.1 - 1.6e-07 31.4 0.0 0.0054 16.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KPI86717.1 - 2.7e-07 31.2 0.1 0.037 14.6 0.0 2.9 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.6 KPI86717.1 - 4.6e-07 30.4 0.7 0.0088 16.4 0.1 3.4 2 2 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 KPI86717.1 - 4.2e-06 26.2 0.0 0.017 14.3 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 KPI86717.1 - 2.2e-05 24.0 0.1 0.0066 15.8 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KPI86717.1 - 8.8e-05 22.4 0.0 0.094 12.6 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KPI86717.1 - 0.00014 22.0 0.0 0.094 12.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KPI86717.1 - 0.00019 21.4 0.3 0.46 10.4 0.1 4.0 3 1 0 3 3 3 1 NACHT domain RNA_helicase PF00910.22 KPI86717.1 - 0.00034 21.0 0.0 0.34 11.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase RuvB_N PF05496.12 KPI86717.1 - 0.00055 19.7 0.0 0.11 12.3 0.0 2.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 KPI86717.1 - 0.00073 19.3 0.0 0.59 9.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_2 PF07724.14 KPI86717.1 - 0.00074 19.7 0.2 0.011 15.9 0.0 2.7 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 KPI86717.1 - 0.00086 18.9 0.0 0.023 14.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region CDC48_N PF02359.18 KPI86717.1 - 0.0009 19.4 0.0 0.0064 16.6 0.0 2.5 2 1 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_30 PF13604.6 KPI86717.1 - 0.0026 17.5 0.0 0.47 10.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 KPI86717.1 - 0.0026 17.1 0.4 1.6 7.9 0.6 2.8 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 KPI86717.1 - 0.0027 17.7 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 KPI86717.1 - 0.0029 17.5 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KPI86717.1 - 0.0033 17.7 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KPI86717.1 - 0.0057 16.4 0.0 0.26 11.0 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein ATPase PF06745.13 KPI86717.1 - 0.0058 16.0 0.1 0.46 9.8 0.1 2.5 2 0 0 2 2 2 1 KaiC AAA_17 PF13207.6 KPI86717.1 - 0.0071 16.8 1.1 4.1 7.8 0.0 3.5 3 1 0 3 3 3 1 AAA domain ABC_tran PF00005.27 KPI86717.1 - 0.0074 16.8 0.3 1 9.9 0.0 3.0 2 1 1 3 3 3 1 ABC transporter Zeta_toxin PF06414.12 KPI86717.1 - 0.0093 15.3 0.0 0.82 8.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.6 KPI86717.1 - 0.015 15.6 0.8 1.9 8.8 0.1 3.3 4 0 0 4 4 3 0 AAA domain Sigma54_activ_2 PF14532.6 KPI86717.1 - 0.017 15.3 0.0 6.9 6.8 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 KPI86717.1 - 0.023 14.4 0.0 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase CPT PF07931.12 KPI86717.1 - 0.026 14.3 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 KPI86717.1 - 0.035 13.3 0.1 1.8 7.7 0.1 2.5 3 0 0 3 3 2 0 NB-ARC domain KTI12 PF08433.10 KPI86717.1 - 0.051 13.0 0.1 11 5.3 0.0 2.8 3 0 0 3 3 3 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 KPI86717.1 - 0.057 13.1 0.0 1 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 KPI86717.1 - 0.07 13.1 0.0 3.3 7.7 0.0 3.0 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 KPI86717.1 - 0.16 11.8 1.1 7 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain zf-C3HC4_3 PF13920.6 KPI86718.1 - 4.1e-16 58.6 42.3 2.9e-11 43.0 21.1 4.2 3 2 2 5 5 5 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI86718.1 - 0.012 15.5 47.3 0.014 15.2 9.0 3.6 4 1 0 4 4 4 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KPI86718.1 - 9.5 6.7 52.7 0.27 11.6 12.0 3.8 4 0 0 4 4 4 0 Ring finger domain DUF5321 PF17254.2 KPI86719.1 - 0.026 14.0 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5321) GAS PF13851.6 KPI86719.1 - 0.029 13.7 0.3 0.032 13.6 0.3 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4665 PF15679.5 KPI86719.1 - 0.11 13.2 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) GCV_T PF01571.21 KPI86720.1 - 7.3e-79 264.8 0.0 8.7e-79 264.5 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 KPI86720.1 - 1e-20 73.5 0.1 1.9e-20 72.6 0.1 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Gly_reductase PF09338.11 KPI86720.1 - 0.15 10.4 0.0 0.23 9.8 0.0 1.2 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase component B subunits CH PF00307.31 KPI86721.1 - 0.02 15.1 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 Calponin homology (CH) domain EST1 PF10374.9 KPI86721.1 - 0.16 12.6 1.0 11 6.6 0.1 2.7 2 0 0 2 2 2 0 Telomerase activating protein Est1 XkdW PF09636.10 KPI86721.1 - 0.31 11.1 2.0 0.64 10.1 0.2 2.4 2 0 0 2 2 2 0 XkdW protein Tropomyosin PF00261.20 KPI86721.1 - 1.7 7.9 14.3 0.88 8.9 1.4 3.1 3 0 0 3 3 3 0 Tropomyosin Prefoldin PF02996.17 KPI86721.1 - 3.7 7.5 6.5 2.1 8.3 0.0 2.9 3 0 0 3 3 3 0 Prefoldin subunit Not3 PF04065.15 KPI86721.1 - 4.7 6.6 6.8 0.84 9.0 0.0 2.8 4 0 0 4 4 4 0 Not1 N-terminal domain, CCR4-Not complex component MORN PF02493.20 KPI86722.1 - 4.2e-19 67.2 61.7 4.5e-05 23.1 0.3 9.5 10 0 0 10 10 10 7 MORN repeat DUF448 PF04296.13 KPI86722.1 - 0.088 12.7 1.4 11 6.0 0.0 3.9 2 2 2 4 4 4 0 Protein of unknown function (DUF448) PPV_E2_N PF00508.17 KPI86722.1 - 7.3 5.9 8.0 7 5.9 1.1 2.3 2 0 0 2 2 2 0 E2 (early) protein, N terminal NAC PF01849.18 KPI86723.1 - 1e-17 63.8 0.0 1.5e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 NAC domain Succ_CoA_lig PF13607.6 KPI86723.1 - 0.12 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain Ribosomal_L1 PF00687.21 KPI86724.1 - 3.6e-40 137.9 2.2 4.3e-40 137.6 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Peptidase_M41 PF01434.18 KPI86725.1 - 9.4e-46 156.1 2.0 1.4e-45 155.5 2.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KPI86725.1 - 2e-39 135.0 0.0 3.9e-39 134.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI86725.1 - 4.6e-06 27.1 2.3 5.6e-05 23.6 0.2 3.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KPI86725.1 - 0.00029 21.1 0.4 0.006 16.9 0.4 2.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KPI86725.1 - 0.00063 19.8 0.2 0.0066 16.5 0.2 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KPI86725.1 - 0.00089 19.4 1.3 0.004 17.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 KPI86725.1 - 0.0011 18.8 0.2 0.032 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KPI86725.1 - 0.0063 16.3 0.1 0.077 12.7 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 KPI86725.1 - 0.013 15.2 0.1 0.083 12.6 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 KPI86725.1 - 0.055 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_lid_3 PF17862.1 KPI86725.1 - 0.058 13.2 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA+ lid domain IstB_IS21 PF01695.17 KPI86725.1 - 0.064 13.0 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 KPI86725.1 - 0.065 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 KPI86725.1 - 0.078 12.3 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.9 KPI86725.1 - 0.084 12.1 0.4 0.14 11.4 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 KPI86725.1 - 0.1 12.5 0.2 0.52 10.2 0.1 2.1 2 0 0 2 2 2 0 NACHT domain Peptidase_M50B PF13398.6 KPI86725.1 - 0.16 11.6 0.1 0.39 10.3 0.1 1.6 1 0 0 1 1 1 0 Peptidase M50B-like AAA_25 PF13481.6 KPI86725.1 - 0.2 11.2 1.9 4.1 6.9 0.4 2.5 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 KPI86727.1 - 6.2e-35 120.5 0.0 1.1e-34 119.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KPI86727.1 - 8.4e-06 25.8 0.0 2.7e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI86727.1 - 6.1e-05 23.5 0.1 0.00089 19.7 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI86727.1 - 0.00056 20.2 0.0 0.071 13.4 0.0 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 KPI86727.1 - 0.00091 18.5 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 KPI86727.1 - 0.0016 18.2 0.0 0.0031 17.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KPI86727.1 - 0.0034 17.5 0.0 0.017 15.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KPI86727.1 - 0.0085 15.8 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Vps4_C PF09336.10 KPI86727.1 - 0.01 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain AAA_24 PF13479.6 KPI86727.1 - 0.025 14.3 0.0 0.047 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KPI86727.1 - 0.028 14.3 0.9 6.7 6.6 0.0 2.9 2 1 1 3 3 3 0 NACHT domain AAA_2 PF07724.14 KPI86727.1 - 0.033 14.3 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 KPI86727.1 - 0.044 14.2 0.0 0.12 12.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_lid_3 PF17862.1 KPI86727.1 - 0.06 13.2 0.0 0.34 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA+ lid domain AAA_19 PF13245.6 KPI86727.1 - 0.066 13.5 0.1 0.16 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KPI86727.1 - 0.067 13.6 0.0 0.84 10.0 0.0 2.5 3 0 0 3 3 3 0 RNA helicase Mg_chelatase PF01078.21 KPI86727.1 - 0.072 12.5 0.1 0.27 10.6 0.1 1.9 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 KPI86727.1 - 0.2 10.7 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Tyr_Deacylase PF02580.16 KPI86728.1 - 9.8e-28 97.5 0.0 1.4e-27 97.0 0.0 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Aldose_epim PF01263.20 KPI86730.1 - 8.6e-35 120.5 0.0 1e-34 120.2 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase HECT PF00632.25 KPI86731.1 - 2.4e-13 50.3 0.0 0.00035 20.2 0.0 3.1 3 0 0 3 3 3 3 HECT-domain (ubiquitin-transferase) HECT PF00632.25 KPI86732.1 - 1.8e-06 27.7 0.0 4e-06 26.5 0.0 1.4 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) CAP_N PF01213.19 KPI86732.1 - 3.2 7.2 6.0 0.2 11.1 0.7 1.6 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Lactamase_B PF00753.27 KPI86733.1 - 1.1e-08 35.3 0.1 5.3e-08 33.1 0.1 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KPI86733.1 - 5.1e-05 22.9 0.0 9.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain HAGH_C PF16123.5 KPI86733.1 - 0.048 14.2 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus Beta-Casp PF10996.8 KPI86734.1 - 5.2e-31 107.2 0.0 1.5e-30 105.7 0.0 1.9 1 0 0 1 1 1 1 Beta-Casp domain CPSF73-100_C PF11718.8 KPI86734.1 - 3.3e-28 98.7 0.0 5e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B PF00753.27 KPI86734.1 - 6.7e-24 85.0 0.0 1.4e-23 84.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 KPI86734.1 - 1.8e-17 63.5 0.0 4.7e-17 62.1 0.0 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 KPI86734.1 - 1.1e-12 47.6 0.0 3.3e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 KPI86734.1 - 4.3e-10 39.5 0.7 2.4e-08 33.7 0.1 2.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KPI86734.1 - 0.00025 21.0 0.0 0.0021 18.0 0.0 2.4 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Topoisom_I PF01028.20 KPI86736.1 - 2.6e-93 311.6 2.1 2.6e-93 311.6 2.1 1.7 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 KPI86736.1 - 4.5e-90 300.8 1.2 4.5e-90 300.8 1.2 3.0 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Macoilin PF09726.9 KPI86736.1 - 0.46 9.0 24.4 0.81 8.2 24.4 1.3 1 0 0 1 1 1 0 Macoilin family LRR_9 PF14580.6 KPI86737.1 - 3.3e-05 23.5 0.1 6.2e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KPI86737.1 - 0.0074 16.7 0.6 0.069 13.6 0.1 2.7 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) zf-RanBP PF00641.18 KPI86738.1 - 2.5e-05 23.5 2.6 2.5e-05 23.5 2.6 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-CCCH_4 PF18044.1 KPI86738.1 - 0.0008 19.1 1.0 0.0008 19.1 1.0 3.0 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI86738.1 - 0.0076 16.3 1.5 0.022 14.8 1.5 1.9 1 0 0 1 1 1 1 Zinc finger domain HypA PF01155.19 KPI86738.1 - 0.089 12.8 0.9 0.23 11.5 0.9 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CCCH PF00642.24 KPI86738.1 - 0.15 12.0 1.8 0.42 10.6 1.8 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Amidinotransf PF02274.17 KPI86739.1 - 3.1e-07 29.8 0.0 4.5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Amidinotransferase DHODB_Fe-S_bind PF10418.9 KPI86739.1 - 0.58 10.0 3.1 0.5 10.2 1.0 2.0 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Amidinotransf PF02274.17 KPI86740.1 - 1.3e-19 70.5 0.0 1.9e-19 70.0 0.0 1.3 1 1 0 1 1 1 1 Amidinotransferase PAS_4 PF08448.10 KPI86740.1 - 0.13 12.6 0.0 12 6.2 0.0 3.1 2 1 1 3 3 3 0 PAS fold Lactonase PF10282.9 KPI86740.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller TPR_12 PF13424.6 KPI86741.1 - 3.2e-34 117.1 15.3 1.8e-06 28.1 0.3 7.1 3 1 4 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 KPI86741.1 - 1.6e-26 91.3 22.7 3.3e-05 23.6 0.0 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86741.1 - 0.0012 18.9 21.2 1.1 9.7 0.2 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI86741.1 - 0.066 13.6 8.9 12 6.5 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86741.1 - 0.087 13.7 13.6 11 7.1 0.1 5.4 4 1 2 6 6 6 0 Tetratricopeptide repeat DUF4918 PF16265.5 KPI86741.1 - 0.09 12.3 0.2 8.8 5.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4918) Ribonuc_red_lgN PF00317.21 KPI86741.1 - 0.096 12.7 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain TPR_16 PF13432.6 KPI86741.1 - 2.4 8.9 16.0 29 5.4 0.4 5.2 4 3 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86741.1 - 2.9 8.4 12.6 0.45 11.1 1.2 4.4 4 2 2 6 6 6 0 Tetratricopeptide repeat TIP49 PF06068.13 KPI86742.1 - 4.5e-167 555.6 0.6 7.3e-167 554.9 0.6 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KPI86742.1 - 3.9e-22 78.1 0.1 1.6e-21 76.2 0.1 2.1 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KPI86742.1 - 3e-11 43.9 0.6 3.7e-07 30.6 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KPI86742.1 - 7.7e-10 38.7 0.0 2e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KPI86742.1 - 6.2e-07 29.8 0.1 0.0095 16.2 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KPI86742.1 - 6.1e-05 23.5 0.1 0.0021 18.5 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 KPI86742.1 - 0.0016 17.9 0.2 0.067 12.6 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KPI86742.1 - 0.0017 18.3 0.1 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 KPI86742.1 - 0.0023 18.3 0.6 2.5 8.4 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KPI86742.1 - 0.003 17.7 0.1 0.023 14.8 0.0 2.4 3 0 0 3 3 3 1 AAA domain ResIII PF04851.15 KPI86742.1 - 0.013 15.5 0.3 1.5 8.8 0.0 2.4 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 KPI86742.1 - 0.016 15.4 0.0 0.036 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 KPI86742.1 - 0.017 14.5 0.0 0.038 13.3 0.0 1.6 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_25 PF13481.6 KPI86742.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain TFIID-31kDa PF02291.15 KPI86742.1 - 0.024 14.7 0.0 0.37 10.9 0.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit AAA_11 PF13086.6 KPI86742.1 - 0.029 14.1 1.4 0.13 12.0 1.5 2.0 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KPI86742.1 - 0.056 14.0 0.1 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KPI86742.1 - 0.057 12.9 0.0 0.28 10.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region Rad17 PF03215.15 KPI86742.1 - 0.071 13.0 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain IstB_IS21 PF01695.17 KPI86742.1 - 0.087 12.6 0.9 0.19 11.4 0.0 2.0 3 0 0 3 3 3 0 IstB-like ATP binding protein TsaE PF02367.17 KPI86742.1 - 0.096 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KPI86742.1 - 0.097 12.4 0.1 16 5.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_17 PF13207.6 KPI86742.1 - 0.14 12.6 1.0 1.8 9.0 0.1 2.8 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.6 KPI86742.1 - 0.15 11.8 0.7 7 6.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain SET PF00856.28 KPI86743.1 - 1.1e-05 25.9 0.0 1.7e-05 25.3 0.0 1.3 1 1 0 1 1 1 1 SET domain AAA PF00004.29 KPI86744.1 - 3.8e-48 163.3 0.0 9.7e-37 126.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 KPI86744.1 - 1.2e-15 57.7 0.3 3e-15 56.4 0.3 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.6 KPI86744.1 - 4e-12 46.9 3.5 5.9e-05 23.5 0.3 4.2 2 2 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 KPI86744.1 - 1.9e-08 34.7 0.2 0.0085 16.4 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KPI86744.1 - 1.7e-07 30.9 0.0 0.0083 15.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 KPI86744.1 - 2.2e-07 31.1 0.0 0.013 15.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 KPI86744.1 - 1.6e-06 27.5 0.0 0.00014 21.2 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 KPI86744.1 - 9.9e-06 25.4 0.1 0.15 11.7 0.0 2.7 3 0 0 3 3 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_14 PF13173.6 KPI86744.1 - 2.9e-05 24.1 0.0 0.0025 17.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KPI86744.1 - 2.9e-05 24.4 0.0 0.036 14.4 0.0 3.3 4 0 0 4 4 2 1 RNA helicase AAA_5 PF07728.14 KPI86744.1 - 3.4e-05 23.8 1.0 0.36 10.8 0.0 4.2 5 1 0 5 5 3 2 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 KPI86744.1 - 4.6e-05 24.0 0.0 0.23 12.0 0.0 3.3 3 0 0 3 3 3 1 ABC transporter AAA_29 PF13555.6 KPI86744.1 - 6.6e-05 22.6 0.0 0.14 11.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_19 PF13245.6 KPI86744.1 - 0.00017 21.9 0.1 0.048 14.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 KPI86744.1 - 0.00024 21.1 0.0 0.34 10.8 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain Mg_chelatase PF01078.21 KPI86744.1 - 0.00072 19.0 0.1 0.39 10.1 0.0 2.7 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 KPI86744.1 - 0.0008 19.6 0.0 0.0029 17.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) Vps4_C PF09336.10 KPI86744.1 - 0.00099 19.1 0.0 0.004 17.1 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_25 PF13481.6 KPI86744.1 - 0.001 18.7 3.5 1.9 8.0 0.0 4.9 4 1 2 6 6 5 1 AAA domain RsgA_GTPase PF03193.16 KPI86744.1 - 0.001 19.0 0.1 2.3 8.1 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 KPI86744.1 - 0.0012 18.0 0.1 0.91 8.5 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_28 PF13521.6 KPI86744.1 - 0.0014 18.9 0.0 0.63 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 KPI86744.1 - 0.002 18.1 0.0 0.073 13.0 0.0 2.7 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_23 PF13476.6 KPI86744.1 - 0.0021 18.6 0.1 3.1 8.2 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_lid_3 PF17862.1 KPI86744.1 - 0.0023 17.7 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 1 1 AAA+ lid domain NACHT PF05729.12 KPI86744.1 - 0.0033 17.3 1.9 4.3 7.2 0.0 3.7 2 1 1 3 3 3 1 NACHT domain TsaE PF02367.17 KPI86744.1 - 0.0049 16.9 0.0 3.7 7.5 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 KPI86744.1 - 0.0051 16.6 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 KPI86744.1 - 0.0075 15.6 0.1 0.096 12.0 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family Sigma54_activat PF00158.26 KPI86744.1 - 0.0087 15.8 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.6 KPI86744.1 - 0.015 15.0 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 KPI86744.1 - 0.024 13.7 0.0 0.6 9.2 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain Bac_DnaA PF00308.18 KPI86744.1 - 0.025 14.4 0.1 6.5 6.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein TniB PF05621.11 KPI86744.1 - 0.066 12.6 0.0 3.2 7.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein AAA_18 PF13238.6 KPI86744.1 - 0.088 13.4 0.1 3.8 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 KPI86744.1 - 0.11 12.3 0.0 28 4.4 0.0 3.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Zeta_toxin PF06414.12 KPI86744.1 - 0.13 11.5 0.2 16 4.7 0.0 2.7 3 0 0 3 3 2 0 Zeta toxin TrwB_AAD_bind PF10412.9 KPI86744.1 - 0.15 11.0 0.0 4.7 6.0 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain KAP_NTPase PF07693.14 KPI86744.1 - 0.21 10.8 0.0 0.54 9.4 0.0 1.9 1 1 0 1 1 1 0 KAP family P-loop domain DUF5393 PF17371.2 KPI86745.1 - 0 1167.6 6.6 0 1167.2 6.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5393) PP2C PF00481.21 KPI86746.1 - 3.3e-11 43.3 0.0 5.7e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C Glyco_transf_22 PF03901.17 KPI86749.1 - 2.9e-71 240.9 27.6 3.5e-71 240.6 27.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Snf7 PF03357.21 KPI86751.1 - 0.049 13.2 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Snf7 DUF3455 PF11937.8 KPI86751.1 - 0.17 12.3 0.0 0.25 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) CorA PF01544.18 KPI86752.1 - 4.9e-06 26.1 0.2 1.5e-05 24.5 0.2 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2735 PF10931.8 KPI86752.1 - 0.075 13.7 0.2 0.23 12.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2735) Memo PF01875.17 KPI86753.1 - 8.8e-59 198.9 0.0 1.1e-58 198.6 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Rhabdo_ncap PF00945.18 KPI86754.1 - 0.14 11.0 0.1 0.81 8.5 0.0 2.0 2 0 0 2 2 2 0 Rhabdovirus nucleocapsid protein 3HCDH_N PF02737.18 KPI86755.1 - 1.2e-54 184.9 4.5 1.6e-54 184.5 4.5 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KPI86755.1 - 9.6e-36 122.3 0.0 3.8e-35 120.4 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Methyltransf_25 PF13649.6 KPI86755.1 - 0.0025 18.5 0.0 0.0089 16.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain AlaDh_PNT_C PF01262.21 KPI86755.1 - 0.039 13.2 3.8 0.09 12.1 3.2 1.8 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 KPI86755.1 - 0.057 13.6 1.4 0.16 12.1 1.4 1.8 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_11 PF08241.12 KPI86755.1 - 0.093 13.4 0.0 0.38 11.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 KPI86755.1 - 0.11 12.1 1.5 0.18 11.4 1.5 1.4 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF2680 PF10925.8 KPI86755.1 - 0.87 9.6 3.6 5.7 7.0 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2680) SPEG_u2 PF16650.5 KPI86757.1 - 0.51 10.6 3.6 17 5.7 0.2 2.6 2 0 0 2 2 2 0 Unstructured region on SPEG complex protein HORMA PF02301.18 KPI86758.1 - 9.3e-49 165.9 0.0 1.3e-48 165.4 0.0 1.2 1 0 0 1 1 1 1 HORMA domain DUF3094 PF11293.8 KPI86759.1 - 0.021 14.5 0.4 0.04 13.6 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) Cys_rich_FGFR PF00839.17 KPI86759.1 - 0.099 12.8 0.6 0.57 10.4 0.1 2.1 2 0 0 2 2 2 0 Cysteine rich repeat Peripla_BP_3 PF13377.6 KPI86760.1 - 0.037 14.4 0.3 0.11 12.8 0.3 1.8 1 0 0 1 1 1 0 Periplasmic binding protein-like domain Ribosomal_L24e PF01246.20 KPI86761.1 - 3.8e-21 75.1 1.6 3.8e-21 75.1 1.6 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e WSD PF15613.6 KPI86762.1 - 1.2e-09 38.5 0.4 1.1e-08 35.4 0.0 2.9 2 0 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 KPI86762.1 - 0.019 15.2 0.1 0.047 14.0 0.1 1.6 1 0 0 1 1 1 0 DDT domain WHIM1 PF15612.6 KPI86762.1 - 0.021 14.4 0.0 0.047 13.3 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 BSP_II PF05432.11 KPI86762.1 - 9.4 5.8 39.9 0.01 15.5 16.2 3.0 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) CLAMP PF14769.6 KPI86764.1 - 2.8e-28 98.2 1.5 5e-28 97.5 1.5 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 MHCassoc_trimer PF08831.10 KPI86765.1 - 0.17 11.9 0.3 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain BTAD PF03704.17 KPI86766.1 - 0.18 12.2 5.0 0.55 10.7 0.6 2.6 2 0 0 2 2 2 0 Bacterial transcriptional activator domain DUF4110 PF13422.6 KPI86766.1 - 0.97 9.5 6.9 11 6.1 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) WD40 PF00400.32 KPI86769.1 - 2.6e-12 47.1 12.0 2.8e-06 28.0 0.6 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI86769.1 - 3.2e-09 36.9 0.1 0.38 11.1 0.0 5.6 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_7 PF13176.6 KPI86769.1 - 1.4e-05 24.8 0.3 0.63 10.2 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 KPI86769.1 - 6.8e-05 22.1 0.3 0.47 9.4 0.0 4.1 4 0 0 4 4 4 2 Coatomer WD associated region WD40_like PF17005.5 KPI86769.1 - 0.00011 21.7 0.2 0.89 8.8 0.0 3.3 3 0 0 3 3 3 2 WD40-like domain DUF2802 PF10975.8 KPI86769.1 - 0.0012 19.0 0.1 0.0039 17.3 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2802) Clathrin PF00637.20 KPI86769.1 - 0.0019 18.1 0.0 0.5 10.2 0.0 3.2 1 1 2 3 3 3 1 Region in Clathrin and VPS Nic96 PF04097.14 KPI86769.1 - 0.003 16.1 0.0 0.0057 15.2 0.0 1.4 1 0 0 1 1 1 1 Nup93/Nic96 TPR_14 PF13428.6 KPI86769.1 - 0.0048 17.6 5.3 17 6.6 0.7 5.5 4 1 1 5 5 5 0 Tetratricopeptide repeat zf-RING_6 PF14835.6 KPI86769.1 - 0.021 14.7 0.3 0.021 14.7 0.3 2.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein TPR_MalT PF17874.1 KPI86769.1 - 0.052 12.9 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 MalT-like TPR region TPR_2 PF07719.17 KPI86769.1 - 0.37 11.0 10.4 12 6.3 0.2 5.6 6 0 0 6 6 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI86769.1 - 0.38 11.0 2.9 3.6 7.9 0.0 3.6 5 0 0 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DHR-2 PF06920.13 KPI86769.1 - 0.59 8.7 2.2 1.2 7.7 0.5 2.1 2 1 0 2 2 2 0 Dock homology region 2 TPR_10 PF13374.6 KPI86769.1 - 1.2 9.1 7.1 15 5.6 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI86769.1 - 5.4 7.0 8.9 58 3.7 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat S10_plectin PF03501.15 KPI86770.1 - 1.3e-26 92.4 0.1 1.7e-26 92.1 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Keratin_2_head PF16208.5 KPI86770.1 - 0.11 12.7 10.5 0.15 12.2 10.5 1.2 1 0 0 1 1 1 0 Keratin type II head Acyltransferase PF01553.21 KPI86771.1 - 4.3e-09 36.1 0.0 8e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 KPI86772.1 - 2.9e-09 36.7 0.0 6.9e-09 35.4 0.0 1.6 2 0 0 2 2 2 1 Acyltransferase SLD5_C PF16922.5 KPI86773.1 - 3.5e-07 30.3 0.0 6.5e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 KPI86773.1 - 0.0082 16.6 0.3 0.016 15.7 0.3 1.5 1 0 0 1 1 1 1 GINS complex protein TPR_MLP1_2 PF07926.12 KPI86774.1 - 0.001 19.1 29.2 0.42 10.7 3.0 3.7 3 0 0 3 3 3 3 TPR/MLP1/MLP2-like protein MIP-T3_C PF17749.1 KPI86774.1 - 0.0074 16.3 0.3 0.0074 16.3 0.3 3.6 3 0 0 3 3 3 1 Microtubule-binding protein MIP-T3 C-terminal region HMMR_C PF15908.5 KPI86774.1 - 0.022 15.0 8.7 0.22 11.8 0.9 3.2 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor C-terminal ADIP PF11559.8 KPI86774.1 - 0.029 14.4 33.1 0.061 13.4 1.8 3.6 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KPI86774.1 - 0.06 13.9 35.0 0.25 11.9 4.2 3.6 4 0 0 4 4 3 0 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 KPI86774.1 - 0.09 13.4 31.5 0.59 10.8 2.2 3.5 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 KPI86774.1 - 0.11 13.0 20.2 0.089 13.2 10.8 2.8 2 1 0 2 2 2 0 Fez1 Fmp27_WPPW PF10359.9 KPI86774.1 - 0.11 11.3 11.2 0.75 8.6 0.1 3.0 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain FoP_duplication PF13865.6 KPI86774.1 - 0.16 12.5 5.0 0.4 11.3 5.0 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 ATG16 PF08614.11 KPI86774.1 - 0.45 10.7 36.4 1.4 9.1 3.8 3.9 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Filament PF00038.21 KPI86774.1 - 0.6 9.6 28.0 0.75 9.3 1.5 3.4 3 0 0 3 3 3 0 Intermediate filament protein Spc7 PF08317.11 KPI86774.1 - 0.65 8.8 26.1 0.19 10.5 1.7 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein UPF0242 PF06785.11 KPI86774.1 - 0.92 9.6 25.3 0.24 11.5 12.8 2.9 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF5082 PF16888.5 KPI86774.1 - 1.5 9.1 21.0 3.2 8.1 4.3 4.1 4 1 0 4 4 3 0 Domain of unknown function (DUF5082) Fzo_mitofusin PF04799.13 KPI86774.1 - 1.7 8.2 22.3 0.31 10.6 5.8 3.4 3 0 0 3 3 3 0 fzo-like conserved region Jnk-SapK_ap_N PF09744.9 KPI86774.1 - 2.1 8.5 27.7 0.19 11.9 2.4 3.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Myc-LZ PF02344.15 KPI86774.1 - 2.7 8.2 6.5 0.5 10.5 0.1 2.9 3 0 0 3 3 3 0 Myc leucine zipper domain Phage_GP20 PF06810.11 KPI86774.1 - 2.9 7.7 21.0 0.78 9.5 1.3 3.3 3 0 0 3 3 3 0 Phage minor structural protein GP20 Fib_alpha PF08702.10 KPI86774.1 - 3.4 7.8 22.8 4.9 7.3 4.1 3.9 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 KPI86774.1 - 3.9 8.1 24.7 5.9 7.5 1.4 4.9 6 0 0 6 6 5 0 Syntaxin 6, N-terminal DUF4472 PF14739.6 KPI86774.1 - 4.2 8.1 26.4 0.2 12.4 5.9 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4472) Exonuc_VII_L PF02601.15 KPI86774.1 - 4.3 6.8 16.0 1.5 8.3 5.8 2.6 2 1 0 2 2 2 0 Exonuclease VII, large subunit FlxA PF14282.6 KPI86774.1 - 4.9 7.2 30.4 3.6 7.6 0.3 3.6 3 0 0 3 3 3 0 FlxA-like protein YabA PF06156.13 KPI86774.1 - 6.6 7.4 22.5 2 9.1 3.5 4.4 3 1 1 4 4 4 0 Initiation control protein YabA DUF3450 PF11932.8 KPI86774.1 - 7.9 5.7 32.9 6.1 6.1 1.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) GAS PF13851.6 KPI86774.1 - 8.3 5.7 33.7 0.67 9.3 10.5 3.3 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF2408 PF10303.9 KPI86774.1 - 8.8 6.9 14.9 11 6.6 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) DUF4795 PF16043.5 KPI86774.1 - 9.5 5.8 24.1 1.1 8.9 2.8 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4795) Asparaginase_2 PF01112.18 KPI86775.1 - 1.3e-106 356.1 9.4 1.4e-106 356.0 9.4 1.0 1 0 0 1 1 1 1 Asparaginase G_glu_transpept PF01019.21 KPI86775.1 - 0.23 10.2 3.9 3.5 6.3 0.1 2.1 2 0 0 2 2 2 0 Gamma-glutamyltranspeptidase Peptidase_M1 PF01433.20 KPI86776.1 - 5.3e-64 215.8 0.0 8.5e-64 215.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KPI86776.1 - 5e-32 111.7 0.1 7.8e-32 111.1 0.1 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KPI86776.1 - 1.4e-23 84.1 0.0 7.7e-23 81.6 0.0 2.0 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF3770 PF12603.8 KPI86776.1 - 0.17 11.3 0.0 0.45 10.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3770) OspE PF02471.17 KPI86777.1 - 0.0091 16.2 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 1 Borrelia outer surface protein E NAD_Gly3P_dh_C PF07479.14 KPI86777.1 - 0.018 15.3 0.1 0.032 14.5 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus LRR_9 PF14580.6 KPI86779.1 - 1.6e-17 63.6 0.1 2.7e-17 62.8 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KPI86779.1 - 2.5e-12 46.8 3.5 4.3e-05 23.8 0.2 3.5 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI86779.1 - 5.4e-07 29.3 4.6 1.1e-06 28.2 1.0 2.9 3 1 0 3 3 3 1 Leucine rich repeat LRR_6 PF13516.6 KPI86779.1 - 0.0015 18.5 2.0 8.3 6.8 0.0 3.7 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 KPI86779.1 - 0.73 10.6 6.3 1.1e+02 4.0 0.3 4.4 3 1 0 3 3 3 0 Leucine Rich Repeat Dynamin_M PF01031.20 KPI86780.1 - 5.8e-78 262.0 0.0 1.2e-77 261.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KPI86780.1 - 4.6e-50 170.0 0.2 1.4e-49 168.4 0.0 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 KPI86780.1 - 6.3e-25 87.2 0.3 1.7e-24 85.8 0.3 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KPI86780.1 - 4.3e-05 23.6 0.2 0.00071 19.7 0.2 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI86780.1 - 0.0091 15.5 0.1 4.2 6.9 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_15 PF13175.6 KPI86780.1 - 0.016 14.9 3.5 0.62 9.7 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain zf-TRAF PF02176.18 KPI86783.1 - 0.00047 20.8 12.7 0.0024 18.5 0.1 3.2 2 1 1 3 3 3 2 TRAF-type zinc finger zf-TRAF_2 PF15965.5 KPI86783.1 - 0.087 13.3 0.6 0.087 13.3 0.6 2.4 1 1 1 2 2 2 0 TRAF-like zinc-finger zf_C2HC_14 PF18574.1 KPI86783.1 - 0.17 11.7 1.2 20 5.0 0.0 2.5 2 0 0 2 2 2 0 C2HC Zing finger domain zf_UBZ PF18439.1 KPI86783.1 - 0.28 10.8 5.5 0.44 10.2 0.5 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger FlhC PF05280.11 KPI86783.1 - 1.3 8.7 5.1 15 5.3 0.6 2.3 2 0 0 2 2 2 0 Flagellar transcriptional activator (FlhC) DUF4379 PF14311.6 KPI86784.1 - 1.5e-37 127.7 23.0 2.2e-14 53.5 1.5 3.4 3 0 0 3 3 3 3 Probable Zinc-ribbon domain HypA PF01155.19 KPI86784.1 - 0.00031 20.7 11.3 0.26 11.3 0.0 3.3 1 1 2 3 3 3 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 KPI86784.1 - 0.0051 16.9 20.0 0.016 15.3 0.6 3.8 3 1 1 4 4 4 2 Zinc ribbon domain zf-4CXXC_R1 PF10497.9 KPI86784.1 - 0.86 9.9 13.9 3.7 7.8 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zinc_ribbon_10 PF10058.9 KPI86784.1 - 3.2 7.5 8.9 40 4.0 0.0 4.4 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein DTW PF03942.15 KPI86785.1 - 2.9e-26 92.4 0.2 5e-26 91.6 0.2 1.3 1 0 0 1 1 1 1 DTW domain Papo_T_antigen PF02380.15 KPI86785.1 - 0.0029 17.7 0.5 0.0029 17.7 0.5 2.0 2 0 0 2 2 2 1 T-antigen specific domain DUF1759 PF03564.15 KPI86785.1 - 0.15 11.9 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) GDI PF00996.18 KPI86786.1 - 4e-179 595.7 0.1 4.7e-179 595.5 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 KPI86786.1 - 0.089 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pkinase PF00069.25 KPI86787.1 - 1.5e-38 132.7 0.0 5.7e-36 124.2 0.0 3.4 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86787.1 - 1e-16 61.0 0.0 8.1e-15 54.8 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI86787.1 - 0.039 13.3 0.0 1.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Kinase-like ERG2_Sigma1R PF04622.12 KPI86788.1 - 2.1e-79 265.7 0.2 2.5e-79 265.5 0.2 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein START PF01852.19 KPI86788.1 - 0.16 11.4 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 START domain LRR_4 PF12799.7 KPI86789.1 - 6e-09 36.0 21.6 0.00022 21.5 0.1 5.7 5 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI86789.1 - 6.8e-08 32.0 3.1 14 6.0 0.1 7.8 8 0 0 8 8 8 1 Leucine Rich repeat LRR_8 PF13855.6 KPI86789.1 - 1.6e-07 31.0 14.7 0.0013 18.5 1.7 5.3 3 2 1 4 4 4 3 Leucine rich repeat DUF4841 PF16129.5 KPI86789.1 - 0.0098 16.1 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4841) FNIP PF05725.12 KPI86789.1 - 0.02 15.0 11.1 0.076 13.2 1.0 3.5 3 1 0 3 3 3 0 FNIP Repeat LRR_1 PF00560.33 KPI86789.1 - 0.03 14.8 22.7 15 6.6 0.2 7.6 5 3 2 7 7 7 0 Leucine Rich Repeat Methyltransf_13 PF08421.11 KPI86789.1 - 0.061 13.6 1.1 0.13 12.5 0.2 2.1 2 0 0 2 2 2 0 Putative zinc binding domain Pentapeptide_4 PF13599.6 KPI86789.1 - 0.1 12.8 1.6 0.41 10.9 0.2 2.7 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) LRR_5 PF13306.6 KPI86789.1 - 0.15 12.1 4.0 1.6 8.7 0.0 3.2 3 0 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) VIT1 PF01988.19 KPI86790.1 - 8.5e-15 55.2 5.1 5.2e-14 52.6 5.0 2.0 1 1 0 1 1 1 1 VIT family NDUF_B12 PF08122.12 KPI86790.1 - 0.16 12.1 0.0 43 4.3 0.0 3.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Glyco_transf_24 PF18404.1 KPI86791.1 - 2.2e-129 430.6 1.4 4e-129 429.7 1.4 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 KPI86791.1 - 1.3e-23 84.3 0.0 1.9e-22 80.5 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 KPI86791.1 - 2.7e-18 66.2 0.0 3.7e-17 62.5 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 KPI86791.1 - 1.4e-13 50.9 0.0 3.3e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_12 PF18400.1 KPI86791.1 - 7.2e-13 48.8 0.0 3.9e-12 46.4 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 KPI86791.1 - 0.00075 19.1 0.1 0.0014 18.2 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF4089 PF13318.6 KPI86791.1 - 1.7 9.1 5.1 1.1 9.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4089) DUF4139 PF13598.6 KPI86792.1 - 1.4e-35 122.9 0.0 2.3e-35 122.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF3663 PF12404.8 KPI86792.1 - 0.052 13.6 0.0 0.35 11.0 0.0 2.4 2 0 0 2 2 2 0 Peptidase KELK PF15796.5 KPI86792.1 - 0.056 13.9 3.1 1.7 9.2 0.1 2.5 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Nas2_N PF18265.1 KPI86792.1 - 0.14 12.1 0.9 2.1 8.3 0.1 2.7 2 0 0 2 2 2 0 Nas2 N_terminal domain XPG_I PF00867.18 KPI86793.1 - 9.9e-31 106.0 0.0 1.9e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 KPI86793.1 - 1.1e-27 96.5 0.0 2.3e-27 95.4 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 KPI86793.1 - 7.6e-06 26.4 0.0 3.3e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold XRN_N PF03159.18 KPI86793.1 - 0.024 14.0 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Peptidase_M20 PF01546.28 KPI86793.1 - 0.073 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DUF1641 PF07849.11 KPI86795.1 - 0.017 15.0 0.1 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1641) Vhr1 PF04001.13 KPI86795.1 - 0.085 13.2 0.1 0.25 11.7 0.1 1.7 1 0 0 1 1 1 0 Transcription factor Vhr1 HEAT_EZ PF13513.6 KPI86795.1 - 0.26 11.8 1.9 44 4.7 0.0 4.1 5 0 0 5 5 5 0 HEAT-like repeat PilO PF04350.13 KPI86795.1 - 0.44 10.7 2.6 92 3.2 0.1 3.9 3 1 1 4 4 4 0 Pilus assembly protein, PilO FeS_assembly_P PF01883.19 KPI86795.1 - 5.9 7.1 9.3 1.1e+02 3.1 0.0 5.5 6 1 1 7 7 7 0 Iron-sulfur cluster assembly protein PP-binding PF00550.25 KPI86796.1 - 6.6e-11 42.4 0.1 8.1e-11 42.1 0.1 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site MM_CoA_mutase PF01642.22 KPI86797.1 - 1.6e-230 766.0 0.3 2e-230 765.7 0.3 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 KPI86797.1 - 2.4e-14 53.4 0.1 5.7e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 B12 binding domain TIP120 PF08623.10 KPI86798.1 - 3.1e-07 30.3 0.0 1.4e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 TATA-binding protein interacting (TIP20) FAD_binding_1 PF00667.20 KPI86799.1 - 0.14 11.7 0.1 0.24 11.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain TSNAXIP1_N PF15739.5 KPI86800.1 - 8.6e-14 51.9 0.5 8.6e-14 51.9 0.5 2.7 2 0 0 2 2 2 1 Translin-associated factor X-interacting N-terminus Vps51 PF08700.11 KPI86800.1 - 0.21 11.7 0.1 0.21 11.7 0.1 2.6 2 1 0 2 2 2 0 Vps51/Vps67 XhlA PF10779.9 KPI86800.1 - 0.4 10.9 4.8 0.13 12.5 0.7 2.3 3 0 0 3 3 3 0 Haemolysin XhlA DUF5401 PF17380.2 KPI86800.1 - 2.1 6.3 12.3 3.4 5.6 12.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) SlyX PF04102.12 KPI86800.1 - 2.4 8.8 13.8 0.56 10.9 0.9 4.2 2 1 2 4 4 4 0 SlyX Ribonuclease_3 PF00636.26 KPI86801.1 - 0.027 15.1 0.0 0.2 12.3 0.0 2.2 2 0 0 2 2 2 0 Ribonuclease III domain RRM_1 PF00076.22 KPI86802.1 - 9.4e-14 51.0 0.0 8.7e-08 31.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mito_fiss_reg PF05308.11 KPI86802.1 - 0.04 14.0 1.8 0.07 13.2 1.8 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator AAA PF00004.29 KPI86803.1 - 2.6e-36 124.9 0.0 7.7e-35 120.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI86803.1 - 1.6e-12 48.1 0.3 1.4e-05 25.5 0.1 3.7 3 1 0 4 4 4 2 AAA ATPase domain AAA_lid_3 PF17862.1 KPI86803.1 - 7.3e-05 22.5 0.2 0.00018 21.2 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain Rad17 PF03215.15 KPI86803.1 - 8.2e-05 22.6 0.0 0.0069 16.3 0.0 2.8 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_5 PF07728.14 KPI86803.1 - 0.0018 18.3 0.0 0.015 15.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KPI86803.1 - 0.0044 17.4 0.0 0.34 11.3 0.0 2.4 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 KPI86803.1 - 0.011 14.9 0.0 2.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RuvB_N PF05496.12 KPI86803.1 - 0.018 14.8 0.0 0.29 10.9 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 KPI86803.1 - 0.025 14.1 0.0 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 KPI86803.1 - 0.028 14.3 0.0 1.2 9.0 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 KPI86803.1 - 0.035 14.6 0.0 1.4 9.4 0.0 2.6 2 1 0 2 2 2 0 ABC transporter AAA_14 PF13173.6 KPI86803.1 - 0.036 14.1 0.0 1.7 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KPI86803.1 - 0.11 12.6 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 KPI86803.1 - 0.17 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Nup96 PF12110.8 KPI86805.1 - 1.4e-29 103.2 0.0 2.2e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 KPI86805.1 - 9.5e-09 35.5 0.0 2.6e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Nucleoporin autopeptidase APG9 PF04109.16 KPI86806.1 - 7.3e-60 203.3 1.1 1.2e-59 202.6 1.1 1.3 1 1 0 1 1 1 1 Autophagy protein Apg9 UPF0149 PF03695.13 KPI86807.1 - 0.0052 17.1 3.6 0.0064 16.8 3.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0149) UpxZ PF06603.11 KPI86807.1 - 0.083 13.2 0.4 0.53 10.6 0.2 2.0 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists NPHI_C PF08469.10 KPI86807.1 - 0.084 12.8 0.5 0.12 12.3 0.4 1.4 1 1 0 1 1 1 0 Nucleoside triphosphatase I C-terminal OTCace_N PF02729.21 KPI86807.1 - 0.093 12.8 2.3 0.15 12.1 2.3 1.6 1 1 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain DnaJ PF00226.31 KPI86808.1 - 1e-24 86.4 0.7 1.8e-24 85.7 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain PfkB PF00294.24 KPI86809.1 - 1.5e-66 224.7 0.1 1.7e-66 224.6 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KPI86809.1 - 2e-10 40.5 0.0 3.1e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Mur_ligase PF01225.25 KPI86809.1 - 0.042 14.2 0.1 0.22 11.9 0.0 2.4 3 0 0 3 3 3 0 Mur ligase family, catalytic domain Brix PF04427.18 KPI86812.1 - 1.1e-28 100.7 1.1 1.3e-28 100.5 0.1 1.6 2 0 0 2 2 2 1 Brix domain Vasohibin PF14822.6 KPI86813.1 - 4.4e-48 163.6 0.0 6.9e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Vasohibin ABC_membrane_2 PF06472.15 KPI86814.1 - 8e-26 91.0 1.0 1.4e-25 90.3 1.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KPI86814.1 - 1.6e-14 54.6 0.0 4.9e-14 53.0 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 KPI86814.1 - 1.9e-07 30.8 0.1 2.3e-06 27.2 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KPI86814.1 - 0.001 19.3 0.4 0.0094 16.2 0.4 2.3 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 KPI86814.1 - 0.0027 17.7 0.0 0.0063 16.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_15 PF13175.6 KPI86814.1 - 0.0044 16.8 0.0 0.0092 15.7 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 KPI86814.1 - 0.0069 16.9 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 KPI86814.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system HTH_43 PF09904.9 KPI86814.1 - 0.086 12.8 0.1 0.24 11.3 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn helix AAA_16 PF13191.6 KPI86814.1 - 0.092 13.1 0.0 0.24 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF2235 PF09994.9 KPI86814.1 - 0.12 11.7 0.1 0.39 10.0 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) ABC_membrane PF00664.23 KPI86814.1 - 0.36 10.4 6.0 0.079 12.6 2.5 1.6 2 0 0 2 2 2 0 ABC transporter transmembrane region Rot1 PF10681.9 KPI86815.1 - 0.17 11.4 0.0 0.44 10.0 0.0 1.7 2 0 0 2 2 2 0 Chaperone for protein-folding within the ER, fungal rve PF00665.26 KPI86817.1 - 0.00093 19.4 0.1 0.00094 19.4 0.1 1.0 1 0 0 1 1 1 1 Integrase core domain CLU PF13236.6 KPI86820.1 - 1.8e-07 31.3 0.0 5.4e-06 26.4 0.0 2.9 1 1 0 1 1 1 1 Clustered mitochondria DUF3181 PF11378.8 KPI86820.1 - 0.01 16.1 0.0 0.076 13.3 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3181) eIF3_p135 PF12807.7 KPI86820.1 - 0.013 15.5 0.2 0.027 14.5 0.2 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 DUF4113 PF13438.6 KPI86820.1 - 0.16 12.1 0.0 0.91 9.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4113) eIF3_p135 PF12807.7 KPI86821.1 - 1.4e-05 25.2 0.0 3.6e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_10 PF13374.6 KPI86821.1 - 0.034 14.0 2.9 23 5.0 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86821.1 - 0.037 14.3 18.9 1.1 9.6 0.2 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat Nop PF01798.18 KPI86822.1 - 7.1e-14 51.8 0.6 1.3e-13 51.0 0.6 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 KPI86822.1 - 0.13 13.2 7.9 0.17 12.8 6.9 1.7 2 0 0 2 2 2 0 Prp31 C terminal domain DUF1883 PF08980.10 KPI86822.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1883) ANAPC4_WD40 PF12894.7 KPI86823.1 - 0.0007 19.9 0.0 0.032 14.5 0.0 3.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI86823.1 - 0.0016 19.2 1.4 0.081 13.8 0.0 3.9 2 1 1 3 3 3 1 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 KPI86823.1 - 0.076 11.5 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain Band_7 PF01145.25 KPI86824.1 - 3.9e-23 82.4 2.8 5.3e-23 81.9 2.8 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 KPI86824.1 - 0.00033 19.8 0.7 0.00042 19.5 0.7 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial Med2 PF11214.8 KPI86824.1 - 0.072 13.2 0.4 0.13 12.4 0.4 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 MIF4G PF02854.19 KPI86825.1 - 3.4e-25 88.9 3.2 5.3e-25 88.3 3.2 1.3 1 0 0 1 1 1 1 MIF4G domain RRM_1 PF00076.22 KPI86826.1 - 2e-14 53.2 0.0 3e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI86826.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Kinesin PF00225.23 KPI86827.1 - 9.6e-73 245.0 0.0 7e-42 143.5 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI86827.1 - 2.4e-17 63.2 0.0 5.4e-17 62.1 0.0 1.5 1 1 0 1 1 1 1 Microtubule binding TPR_6 PF13174.6 KPI86829.1 - 0.12 13.0 0.4 5.4 7.9 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Flag1_repress PF03614.13 KPI86829.1 - 0.16 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Repressor of phase-1 flagellin WD40 PF00400.32 KPI86830.1 - 3.4e-16 59.3 9.2 0.027 15.3 0.1 7.7 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI86830.1 - 5.3e-05 23.5 0.1 2 8.8 0.0 6.3 6 1 2 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain Asp4 PF16996.5 KPI86830.1 - 0.059 13.2 0.3 0.15 11.8 0.3 1.7 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 KIP1 PF07765.12 KPI86830.1 - 7.9 6.7 12.1 0.41 10.8 1.3 4.0 2 1 1 3 3 3 0 KIP1-like protein DNA_pol_B PF00136.21 KPI86831.1 - 1e-125 420.0 0.0 1.4e-125 419.7 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KPI86831.1 - 6.7e-35 120.8 0.0 1.6e-34 119.6 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 KPI86831.1 - 0.00082 19.2 0.9 0.35 10.6 1.0 2.4 2 0 0 2 2 2 2 DNA Polymerase alpha zinc finger DNA_pol_B_2 PF03175.13 KPI86831.1 - 0.031 13.2 0.0 0.061 12.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral ERO1 PF04137.15 KPI86832.1 - 2.1e-88 296.9 0.0 2.6e-88 296.6 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) OTT_1508_deam PF14441.6 KPI86834.1 - 0.084 12.9 0.1 9.9 6.3 0.0 2.2 2 0 0 2 2 2 0 OTT_1508-like deaminase Myosin_TH1 PF06017.13 KPI86835.1 - 5.4e-15 55.5 0.0 1.6e-06 27.9 0.0 3.5 3 0 0 3 3 3 3 Unconventional myosin tail, actin- and lipid-binding PH PF00169.29 KPI86835.1 - 6.1e-05 23.5 0.9 0.00037 21.0 0.1 2.7 3 0 0 3 3 3 1 PH domain RAC_head PF16717.5 KPI86836.1 - 8.8 7.4 5.3 22 6.1 0.0 3.8 5 0 0 5 5 5 0 Ribosome-associated complex head domain UvdE PF03851.14 KPI86837.1 - 0.047 12.9 0.1 0.074 12.3 0.1 1.3 1 0 0 1 1 1 0 UV-endonuclease UvdE Phage_term_sma PF07141.11 KPI86837.1 - 0.071 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Putative bacteriophage terminase small subunit TolA_bind_tri PF16331.5 KPI86840.1 - 0.0091 16.1 11.5 0.0091 16.1 11.5 10.8 6 4 5 11 11 11 1 TolA binding protein trimerisation HSP70 PF00012.20 KPI86841.1 - 5.2e-108 361.8 5.6 1.3e-99 334.0 0.0 2.7 3 0 0 3 3 3 2 Hsp70 protein FGGY_C PF02782.16 KPI86841.1 - 2.4e-05 24.1 1.1 5.7e-05 22.9 0.0 2.1 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain MreB_Mbl PF06723.13 KPI86841.1 - 0.00023 20.1 4.0 0.001 17.9 0.0 3.2 3 1 0 3 3 3 1 MreB/Mbl protein Herpes_U59 PF04529.12 KPI86841.1 - 0.06 12.4 0.5 6.6 5.7 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus U59 protein E1_dh PF00676.20 KPI86842.1 - 1.1e-98 329.9 0.0 1.3e-98 329.7 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KPI86842.1 - 0.00038 19.8 0.6 0.0012 18.1 0.0 1.9 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase DUF1451 PF07295.11 KPI86842.1 - 0.054 13.5 2.1 0.09 12.8 2.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Ribosomal_L34e PF01199.18 KPI86844.1 - 1e-26 93.0 3.4 1e-26 93.0 3.4 2.3 2 1 0 2 2 2 1 Ribosomal protein L34e AAA_assoc_C PF09821.9 KPI86844.1 - 0.27 11.8 3.5 0.18 12.3 1.9 1.5 2 0 0 2 2 2 0 C-terminal AAA-associated domain PUF PF00806.19 KPI86846.1 - 1.4e-46 153.6 6.1 1.8e-06 27.3 0.0 8.7 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat DUF4569 PF15133.6 KPI86846.1 - 0.031 14.0 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) MgtE_N PF03448.17 KPI86846.1 - 0.094 13.3 0.5 4 8.1 0.0 2.9 2 1 0 2 2 2 0 MgtE intracellular N domain DUF445 PF04286.12 KPI86846.1 - 0.14 12.0 0.4 5.5 6.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF445) DnaJ PF00226.31 KPI86847.1 - 7.1e-19 67.7 0.0 1.5e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain AAA_23 PF13476.6 KPI86847.1 - 0.74 10.3 14.6 0.21 12.0 6.6 2.5 2 0 0 2 2 2 0 AAA domain EF-hand_7 PF13499.6 KPI86848.1 - 1.5e-10 41.4 7.2 2.8e-06 27.7 0.3 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI86848.1 - 1.1e-08 34.3 1.3 0.004 17.0 0.2 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KPI86848.1 - 1.3e-07 30.6 1.4 0.0045 16.4 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KPI86848.1 - 0.0035 17.2 6.4 0.0055 16.5 0.2 3.3 3 1 0 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 KPI86848.1 - 0.05 13.1 0.5 0.54 9.9 0.1 2.4 2 0 0 2 2 2 0 EF hand YebO PF13974.6 KPI86848.1 - 0.059 13.5 0.2 0.13 12.3 0.2 1.5 1 0 0 1 1 1 0 YebO-like protein DUF3648 PF12364.8 KPI86849.1 - 1e-26 93.8 1.0 4.1e-26 91.9 1.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3648) PAP_assoc PF03828.19 KPI86849.1 - 0.21 11.8 0.2 0.5 10.6 0.2 1.6 1 0 0 1 1 1 0 Cid1 family poly A polymerase WD40 PF00400.32 KPI86851.1 - 0.0021 18.9 0.5 0.12 13.3 0.1 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat GST_N_4 PF17172.4 KPI86853.1 - 0.074 13.8 0.0 0.18 12.5 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain NADH-G_4Fe-4S_3 PF10588.9 KPI86854.1 - 2e-15 56.0 0.2 2e-15 56.0 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.6 KPI86854.1 - 2.3e-12 46.8 0.1 6.3e-12 45.4 0.1 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 KPI86854.1 - 2e-07 30.9 0.1 4.8e-07 29.6 0.1 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 KPI86854.1 - 0.09 13.4 6.7 0.19 12.4 3.1 2.9 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 KPI86854.1 - 0.44 10.7 6.0 0.26 11.5 2.4 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 KPI86854.1 - 2.1 8.5 7.4 0.29 11.3 1.1 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain DnaJ PF00226.31 KPI86855.1 - 7.8e-15 54.8 0.0 6.2e-14 51.9 0.0 2.1 1 1 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 KPI86855.1 - 5.4e-05 22.8 3.9 8.1e-05 22.3 3.9 1.3 1 0 0 1 1 1 1 CSL zinc finger A_deamin PF02137.18 KPI86857.1 - 1.4e-21 77.3 0.1 2.9e-21 76.3 0.1 1.5 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain MbtH PF03621.13 KPI86857.1 - 0.073 12.5 0.3 0.21 11.1 0.3 1.8 1 0 0 1 1 1 0 MbtH-like protein FLYWCH PF04500.16 KPI86858.1 - 0.054 13.6 1.4 0.18 12.0 0.7 2.1 2 0 0 2 2 2 0 FLYWCH zinc finger domain DHHC PF01529.20 KPI86859.1 - 1.2e-39 135.5 8.4 1.2e-39 135.5 8.4 1.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase HemY_N PF07219.13 KPI86859.1 - 9.4 6.5 9.5 0.33 11.1 0.7 2.6 2 0 0 2 2 2 0 HemY protein N-terminus DUF5558 PF17713.1 KPI86860.1 - 0.15 12.5 4.2 1 9.7 0.3 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5558) Peptidase_M14 PF00246.24 KPI86862.1 - 4.9e-12 46.3 0.0 1.5e-11 44.6 0.0 1.8 2 0 0 2 2 2 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 KPI86862.1 - 2.1e-07 31.2 0.1 5.4e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AAA_35 PF14516.6 KPI86863.1 - 0.025 13.4 0.0 0.036 12.9 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain RIF5_SNase_2 PF18189.1 KPI86864.1 - 1.3e-22 80.3 0.0 1.5e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 TbRIF5 SNase domain 2 Tetraspanin PF00335.20 KPI86867.1 - 2.1e-08 34.2 13.7 2.9e-08 33.7 13.3 1.4 1 1 0 1 1 1 1 Tetraspanin family DUF4064 PF13273.6 KPI86868.1 - 1.1 9.6 13.0 0.26 11.6 5.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Iwr1 PF08574.10 KPI86869.1 - 0.028 15.4 10.6 0.047 14.7 8.6 2.5 2 1 0 2 2 2 0 Transcription factor Iwr1 Ank_2 PF12796.7 KPI86870.1 - 8.2e-10 39.1 0.0 2.6e-07 31.1 0.0 2.9 2 2 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI86870.1 - 1.6e-07 31.7 0.1 1.6e-05 25.4 0.1 3.8 4 2 1 5 5 5 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI86870.1 - 1.9e-07 31.2 0.6 4.2e-05 23.8 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI86870.1 - 1.1e-06 28.5 0.3 0.0013 19.0 0.1 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KPI86870.1 - 0.001 19.4 1.4 0.0041 17.5 0.4 2.6 2 0 0 2 2 2 1 Ankyrin repeat 3HCDH PF00725.22 KPI86870.1 - 0.1 13.2 0.0 0.32 11.6 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Nop PF01798.18 KPI86871.1 - 1.5e-47 162.0 0.0 1.8e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin CEP19 PF14933.6 KPI86872.1 - 2.4e-43 148.3 0.0 4.2e-43 147.5 0.0 1.4 1 0 0 1 1 1 1 CEP19-like protein Peptidase_M3 PF01432.20 KPI86875.1 - 3.9e-115 385.7 0.0 4.8e-115 385.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 KPI86875.1 - 0.03 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Zip PF02535.22 KPI86876.1 - 8.1e-16 58.1 12.0 1.5e-11 44.1 1.0 3.0 2 1 1 3 3 3 2 ZIP Zinc transporter HEAT PF02985.22 KPI86879.1 - 2.9e-06 27.1 0.4 0.019 15.2 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat UVR PF02151.19 KPI86879.1 - 8.4e-06 25.4 7.8 0.0015 18.2 1.7 2.6 2 0 0 2 2 2 2 UvrB/uvrC motif Cnd3 PF12719.7 KPI86879.1 - 0.018 14.3 0.1 0.04 13.1 0.1 1.6 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain XRCC1_N PF01834.16 KPI86879.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 XRCC1 N terminal domain HEAT_EZ PF13513.6 KPI86879.1 - 0.36 11.4 2.4 1.9 9.1 0.0 3.1 3 0 0 3 3 3 0 HEAT-like repeat WD40 PF00400.32 KPI86880.1 - 5.1e-27 93.6 9.9 1.3e-06 29.0 0.2 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI86880.1 - 2.5e-18 66.2 0.4 9e-05 22.7 0.0 5.6 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KPI86880.1 - 9.5e-05 22.1 0.6 0.0013 18.4 0.1 2.6 1 1 2 3 3 3 1 PQQ-like domain Ge1_WD40 PF16529.5 KPI86880.1 - 0.00088 18.3 0.5 3.5 6.5 0.0 4.2 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KPI86880.1 - 0.0042 16.5 0.0 0.23 10.8 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain WDCP PF15390.6 KPI86880.1 - 0.0055 15.2 0.1 0.0097 14.3 0.1 1.3 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family Frtz PF11768.8 KPI86880.1 - 0.055 11.8 0.0 2.2 6.5 0.0 2.8 1 1 2 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 KPI86880.1 - 0.069 13.1 0.0 5.1 7.2 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Herpes_UL52 PF03121.15 KPI86883.1 - 2.8e-12 46.4 0.2 6.4e-12 45.3 0.2 1.6 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase DUF448 PF04296.13 KPI86883.1 - 0.16 11.9 0.2 17 5.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF448) LysM PF01476.20 KPI86885.1 - 1.3e-09 38.0 0.0 0.0014 18.6 0.0 3.4 3 0 0 3 3 3 2 LysM domain Death PF00531.22 KPI86885.1 - 0.033 14.4 0.0 10 6.4 0.0 3.4 3 0 0 3 3 3 0 Death domain DUF3606 PF12244.8 KPI86885.1 - 0.057 13.4 0.7 25 4.9 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3606) HTH_23 PF13384.6 KPI86885.1 - 0.1 12.5 0.1 4.6 7.1 0.0 3.1 3 0 0 3 3 3 0 Homeodomain-like domain Rhodanese PF00581.20 KPI86886.1 - 3.2e-10 40.5 0.0 6.5e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain FAD_binding_2 PF00890.24 KPI86887.1 - 8.6e-86 288.6 0.1 1.2e-85 288.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain ApbE PF02424.15 KPI86887.1 - 1.2e-52 179.0 0.1 9.9e-52 176.0 0.0 2.0 1 1 1 2 2 2 1 ApbE family NAD_binding_1 PF00175.21 KPI86887.1 - 1e-16 61.5 0.0 2.2e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DAO PF01266.24 KPI86887.1 - 6.8e-12 45.6 2.6 5.3e-11 42.7 2.6 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KPI86887.1 - 6e-10 39.0 3.9 1.7e-09 37.6 3.9 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KPI86887.1 - 2.4e-09 36.8 0.9 1.4e-08 34.4 0.5 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_6 PF00970.24 KPI86887.1 - 5.7e-08 33.0 0.0 1.3e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain GIDA PF01134.22 KPI86887.1 - 3e-07 29.9 7.9 3e-06 26.6 3.9 2.7 3 0 0 3 3 3 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 KPI86887.1 - 3.4e-07 29.8 0.6 7.3e-07 28.7 0.6 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 KPI86887.1 - 2.8e-06 27.5 1.8 1.1e-05 25.5 1.8 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_6 PF08030.12 KPI86887.1 - 5.2e-06 26.7 0.2 0.0034 17.5 0.0 3.0 3 0 0 3 3 3 1 Ferric reductase NAD binding domain HI0933_like PF03486.14 KPI86887.1 - 4e-05 22.5 5.4 0.00024 20.0 2.6 2.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 KPI86887.1 - 0.00063 20.3 3.1 0.0049 17.4 0.4 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KPI86887.1 - 0.00097 18.5 0.3 0.022 14.0 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KPI86887.1 - 0.0055 16.0 0.7 0.0085 15.4 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KPI86887.1 - 0.0088 15.3 0.8 0.029 13.6 0.8 1.8 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 KPI86887.1 - 0.041 12.9 3.0 0.13 11.3 1.5 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 KPI86888.1 - 3.2e-90 303.2 0.2 3.9e-90 302.9 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 KPI86888.1 - 5.2e-09 35.7 0.3 1.1e-08 34.7 0.3 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KPI86888.1 - 5.7e-09 36.0 4.7 8.7e-08 32.1 4.5 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KPI86888.1 - 4.6e-08 33.2 0.4 1.3e-07 31.7 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 KPI86888.1 - 2.5e-07 30.4 3.1 4e-07 29.7 3.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KPI86888.1 - 0.00064 19.1 0.1 0.00092 18.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 KPI86888.1 - 0.0039 16.3 1.5 0.0039 16.3 1.5 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 KPI86888.1 - 0.0044 16.3 0.9 0.13 11.5 0.6 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KPI86888.1 - 0.044 12.5 8.7 0.027 13.2 1.1 3.0 4 0 0 4 4 4 0 HI0933-like protein AlaDh_PNT_C PF01262.21 KPI86888.1 - 0.058 12.7 0.3 0.099 11.9 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 KPI86888.1 - 0.082 13.5 1.0 2.2 8.9 0.4 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 KPI86888.1 - 0.35 9.6 0.6 3.7 6.2 0.3 2.0 2 0 0 2 2 2 0 MCRA family Thi4 PF01946.17 KPI86888.1 - 0.53 9.5 3.6 0.3 10.3 1.1 1.7 2 0 0 2 2 2 0 Thi4 family HA2 PF04408.23 KPI86889.1 - 1.4e-21 76.8 0.0 3.3e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI86889.1 - 2.1e-15 57.0 0.0 5.7e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KPI86889.1 - 4.8e-13 49.3 0.0 1.2e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KPI86889.1 - 3.7e-08 33.3 0.1 1.2e-07 31.7 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI86889.1 - 2.7e-06 27.7 0.0 6.3e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KPI86889.1 - 0.00021 20.8 0.0 0.00053 19.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 KPI86889.1 - 0.00024 21.4 0.0 0.00051 20.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KPI86889.1 - 0.00084 19.4 0.0 0.026 14.5 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 KPI86889.1 - 0.0024 17.0 0.0 0.0054 15.8 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 KPI86889.1 - 0.0034 17.9 0.1 0.088 13.3 0.0 2.4 1 1 1 2 2 2 1 ABC transporter AAA_30 PF13604.6 KPI86889.1 - 0.0042 16.8 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KPI86889.1 - 0.0094 15.7 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 KPI86889.1 - 0.036 13.7 0.0 0.076 12.6 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activat PF00158.26 KPI86889.1 - 0.048 13.4 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain GIT_SHD PF08518.11 KPI86889.1 - 0.059 13.0 0.2 0.18 11.5 0.2 1.9 1 0 0 1 1 1 0 Spa2 homology domain (SHD) of GIT AAA_16 PF13191.6 KPI86889.1 - 0.13 12.7 0.1 0.35 11.2 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 KPI86889.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 KaiC HTH_IclR PF09339.10 KPI86889.1 - 0.15 11.9 0.2 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain AAA_29 PF13555.6 KPI86889.1 - 0.2 11.5 0.0 0.47 10.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Armet PF10208.9 KPI86890.1 - 9.1e-06 25.7 0.5 2.9e-05 24.0 0.0 2.1 2 1 0 2 2 2 1 Degradation arginine-rich protein for mis-folding SAP PF02037.27 KPI86890.1 - 0.065 13.0 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 SAP domain Mob1_phocein PF03637.17 KPI86890.1 - 0.081 12.9 0.6 0.16 12.0 0.6 1.6 1 1 0 1 1 1 0 Mob1/phocein family adh_short PF00106.25 KPI86891.1 - 5.2e-47 159.8 2.3 6.1e-47 159.6 2.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI86891.1 - 3e-36 125.1 1.0 3.8e-36 124.8 1.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI86891.1 - 4.3e-14 52.8 0.1 5.9e-14 52.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI86891.1 - 0.00012 21.6 0.5 0.00032 20.2 0.5 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KPI86891.1 - 0.0029 16.8 2.6 0.014 14.6 2.6 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KPI86891.1 - 0.013 14.5 2.2 0.022 13.7 2.2 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 KPI86891.1 - 0.015 14.7 1.6 0.21 10.9 1.6 2.5 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 KPI86891.1 - 0.027 15.0 0.2 0.057 14.0 0.2 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent zinc_ribbon_5 PF13719.6 KPI86891.1 - 0.12 12.1 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain adh_short PF00106.25 KPI86892.1 - 3.8e-38 130.9 0.0 1.1e-37 129.4 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI86892.1 - 1.7e-21 76.9 0.0 4.8e-21 75.4 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI86892.1 - 6.6e-05 22.9 0.0 0.0001 22.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI86892.1 - 0.00015 21.3 0.0 0.00025 20.6 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 KPI86892.1 - 0.04 13.7 0.0 0.065 13.1 0.0 1.4 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein MFAP1 PF06991.11 KPI86893.1 - 0.00034 20.5 0.3 0.00034 20.5 0.3 1.9 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing DUF1759 PF03564.15 KPI86894.1 - 0.097 12.6 17.8 0.53 10.2 3.4 4.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1759) Glutaredoxin PF00462.24 KPI86895.1 - 1.3e-17 63.7 0.9 3.7e-13 49.5 0.0 2.4 2 0 0 2 2 2 2 Glutaredoxin Thioredoxin PF00085.20 KPI86895.1 - 1.5e-14 53.8 0.1 2.9e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KPI86895.1 - 3.5e-06 27.1 0.0 7e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 KPI86895.1 - 0.034 13.5 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KPI86895.1 - 0.059 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Hydrolase_6 PF13344.6 KPI86895.1 - 0.092 12.9 0.0 0.22 11.7 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase AAA PF00004.29 KPI86896.1 - 1.8e-35 122.2 0.0 4.1e-35 121.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI86896.1 - 3.3e-08 33.2 0.0 7.4e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KPI86896.1 - 1e-07 32.0 0.0 2.9e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI86896.1 - 6e-07 29.3 0.0 2.5e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI86896.1 - 8e-07 29.6 0.2 1.8e-05 25.2 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 KPI86896.1 - 2.1e-06 27.2 0.0 1.3e-05 24.6 0.0 2.0 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 KPI86896.1 - 3.5e-06 27.4 0.1 0.0014 18.9 0.0 2.5 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI86896.1 - 1.4e-05 25.3 0.0 3.2e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI86896.1 - 4.7e-05 24.0 0.0 8.9e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KPI86896.1 - 0.00047 19.9 0.0 0.00079 19.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KPI86896.1 - 0.00055 20.3 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TsaE PF02367.17 KPI86896.1 - 0.0022 18.0 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KPI86896.1 - 0.0024 17.9 0.0 0.0044 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KPI86896.1 - 0.0028 17.4 0.0 0.0045 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KPI86896.1 - 0.0029 17.0 0.0 0.0066 15.9 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KPI86896.1 - 0.0039 17.5 0.0 0.0082 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 KPI86896.1 - 0.0052 16.6 0.0 0.013 15.4 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 KPI86896.1 - 0.0057 16.8 0.0 0.017 15.3 0.0 1.8 2 0 0 2 2 1 1 Shikimate kinase Zeta_toxin PF06414.12 KPI86896.1 - 0.0057 15.9 0.0 0.014 14.6 0.0 1.6 2 0 0 2 2 1 1 Zeta toxin AAA_7 PF12775.7 KPI86896.1 - 0.0076 15.8 0.0 0.018 14.5 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_2 PF07724.14 KPI86896.1 - 0.01 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 KPI86896.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Sigma54_activat PF00158.26 KPI86896.1 - 0.015 15.0 0.0 0.057 13.1 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 KPI86896.1 - 0.017 14.7 1.0 0.21 11.2 0.1 2.4 1 1 0 2 2 2 0 AAA domain NACHT PF05729.12 KPI86896.1 - 0.019 14.9 0.0 0.046 13.6 0.0 1.6 1 1 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.17 KPI86896.1 - 0.023 13.8 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Hydin_ADK PF17213.3 KPI86896.1 - 0.024 14.9 0.0 1.6 8.9 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Cytidylate_kin PF02224.18 KPI86896.1 - 0.027 14.2 0.1 0.082 12.6 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase MMR_HSR1 PF01926.23 KPI86896.1 - 0.046 13.8 0.1 2.6 8.2 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase Sigma54_activ_2 PF14532.6 KPI86896.1 - 0.05 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.6 KPI86896.1 - 0.051 13.3 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KPI86896.1 - 0.052 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI86896.1 - 0.072 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_6 PF12774.7 KPI86896.1 - 0.075 12.0 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region DUF815 PF05673.13 KPI86896.1 - 0.089 11.9 0.0 0.18 11.0 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 KPI86896.1 - 0.094 12.2 0.1 0.22 10.9 0.0 1.6 1 1 0 1 1 1 0 PhoH-like protein PPV_E1_C PF00519.17 KPI86896.1 - 0.11 11.3 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase DUF2075 PF09848.9 KPI86896.1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF5351 PF17302.2 KPI86897.1 - 0.95 9.7 4.2 2.7 8.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5351) fn2 PF00040.19 KPI86897.1 - 1.2 9.4 4.8 3.3 8.1 1.7 2.9 2 1 1 3 3 3 0 Fibronectin type II domain zf-U1 PF06220.12 KPI86897.1 - 4.1 7.2 6.2 0.33 10.7 0.5 2.1 2 0 0 2 2 2 0 U1 zinc finger 2OG-FeII_Oxy_2 PF13532.6 KPI86898.1 - 1.1e-08 35.5 0.0 1.8e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KPI86898.1 - 0.0093 16.4 0.0 0.038 14.5 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Ala_racemase_N PF01168.20 KPI86900.1 - 8.6e-40 136.7 0.9 1.5e-39 135.9 0.9 1.4 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.21 KPI86900.1 - 1.2e-17 63.8 0.2 3e-17 62.6 0.2 1.7 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain UQ_con PF00179.26 KPI86901.1 - 1.4e-54 183.5 0.0 1.6e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KPI86901.1 - 0.0064 16.8 0.0 0.0074 16.6 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KPI86901.1 - 0.13 11.9 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B GDH_N PF12466.8 KPI86902.1 - 0.42 10.9 2.6 2.3 8.5 0.3 2.9 2 0 0 2 2 2 0 Glutamate dehydrogenase N terminal Thioredoxin PF00085.20 KPI86903.1 - 9e-10 38.5 0.0 2.6e-09 37.0 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 KPI86903.1 - 2.6e-05 24.2 0.1 0.28 11.1 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KPI86903.1 - 0.00013 22.3 0.5 0.018 15.5 0.2 3.2 2 1 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KPI86903.1 - 0.019 14.3 0.1 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Fe-S_biosyn PF01521.20 KPI86904.1 - 2.6e-05 24.4 0.0 0.0002 21.5 0.0 2.0 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis GH114_assoc PF14741.6 KPI86904.1 - 0.044 14.0 0.0 0.081 13.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal glycosyl-hydrolase-114-associated domain PgaPase_1 PF06162.12 KPI86904.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative pyroglutamyl peptidase PgaPase_1 CPDase PF07823.11 KPI86905.1 - 0.055 13.2 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein zf-CDGSH PF09360.10 KPI86907.1 - 6.4e-18 64.7 5.7 1.8e-09 37.7 0.2 2.2 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type Peptidase_M16 PF00675.20 KPI86908.1 - 3.2e-28 98.6 0.0 4.8e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KPI86908.1 - 1.1e-13 51.7 0.0 2.1e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain NAD_synthase PF02540.17 KPI86908.1 - 0.034 13.2 0.0 0.074 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD synthase OTU PF02338.19 KPI86909.1 - 1.7e-14 54.4 0.1 3e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease zf-RanBP PF00641.18 KPI86909.1 - 3.7e-05 22.9 1.0 3.7e-05 22.9 1.0 5.4 5 1 1 6 6 6 2 Zn-finger in Ran binding protein and others zf-tcix PF14952.6 KPI86909.1 - 0.014 15.0 0.6 0.014 15.0 0.6 4.2 5 0 0 5 5 5 0 Putative treble-clef, zinc-finger, Zn-binding DZR PF12773.7 KPI86909.1 - 0.3 11.1 30.4 0.43 10.6 7.0 4.2 3 1 0 3 3 3 0 Double zinc ribbon Rubredoxin_2 PF18073.1 KPI86909.1 - 1.6 8.5 31.7 0.28 10.9 0.4 5.8 5 0 0 5 5 5 0 Rubredoxin metal binding domain RecR PF02132.15 KPI86909.1 - 1.6 8.3 18.9 1.8 8.2 0.8 4.7 3 2 1 4 4 4 0 RecR protein FSA_C PF10479.9 KPI86909.1 - 1.8 6.6 4.4 3.2 5.8 4.4 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ima1_N PF09779.9 KPI86909.1 - 7.9 7.3 18.6 16 6.3 0.1 4.9 4 1 0 4 4 4 0 Ima1 N-terminal domain RRM_1 PF00076.22 KPI86910.1 - 2.2e-06 27.4 0.0 0.024 14.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP-alpha_N PF04086.13 KPI86910.1 - 0.21 11.5 9.7 0.25 11.2 9.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal tRNA-synt_2b PF00587.25 KPI86911.1 - 1e-30 107.0 0.0 2.3e-27 96.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KPI86911.1 - 3.4e-17 62.4 0.0 7.1e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 KPI86911.1 - 1.3e-13 50.7 0.0 2.7e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 KPI86911.1 - 7.1e-12 45.2 0.0 1.2e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TPR_11 PF13414.6 KPI86912.1 - 5.4e-21 74.0 10.3 1.5e-05 24.6 0.0 5.5 3 2 2 5 5 5 4 TPR repeat TPR_1 PF00515.28 KPI86912.1 - 3.1e-19 67.9 9.2 1.6e-05 24.5 0.2 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86912.1 - 2.1e-18 64.9 9.8 0.00013 21.9 0.1 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 KPI86912.1 - 1.5e-16 59.5 10.2 0.0012 19.1 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86912.1 - 7.7e-13 48.1 15.6 0.0012 19.5 0.0 7.1 4 2 4 8 8 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86912.1 - 6e-12 44.8 3.6 0.0032 17.6 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI86912.1 - 2.2e-11 44.2 4.5 1e-06 29.3 0.2 4.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86912.1 - 3.4e-11 43.5 16.5 2.2e-05 24.9 0.2 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86912.1 - 2.3e-07 31.0 2.5 0.00022 21.5 0.0 3.8 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86912.1 - 1.6e-05 24.6 0.2 1.1 9.5 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 KPI86912.1 - 8.2e-05 22.7 0.3 0.0029 17.7 0.1 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KPI86912.1 - 0.005 16.7 8.9 2.3 8.2 1.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI86912.1 - 0.0078 16.3 2.3 7.6 6.7 0.1 3.8 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 KPI86912.1 - 0.022 15.2 7.6 2.2 8.7 0.4 3.7 3 1 1 4 4 4 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 KPI86912.1 - 0.23 12.1 11.6 27 5.7 0.0 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 KPI86912.1 - 2.7 8.4 21.4 2.5 8.5 0.1 5.7 4 1 2 6 6 5 0 Tetratricopeptide repeat DZR PF12773.7 KPI86913.1 - 0.18 11.8 6.9 2 8.5 0.3 3.3 3 0 0 3 3 3 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 KPI86913.1 - 8.4 6.3 6.0 6.9 6.5 0.8 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Ctf8 PF09696.10 KPI86914.1 - 5.2e-09 36.6 0.0 0.00019 21.8 0.0 3.2 3 0 0 3 3 3 3 Ctf8 NDUF_B7 PF05676.13 KPI86915.1 - 0.00019 21.1 4.0 0.00033 20.3 4.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 KPI86915.1 - 0.00062 19.7 5.8 0.0013 18.7 5.8 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF737 PF05300.11 KPI86915.1 - 0.047 14.0 2.4 0.058 13.7 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) HEPN_RnaseLS PF18869.1 KPI86915.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 RnaseLS-like HEPN CHCH PF06747.13 KPI86915.1 - 0.11 12.7 5.6 0.28 11.4 5.7 1.7 1 1 0 1 1 1 0 CHCH domain Pet191_N PF10203.9 KPI86915.1 - 0.13 12.6 4.0 0.3 11.4 4.0 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 KPI86915.1 - 0.31 11.3 6.9 0.21 11.9 1.4 2.3 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb CX9C PF16860.5 KPI86915.1 - 0.31 11.1 3.8 2.7 8.1 0.2 2.3 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, FAM176 PF14851.6 KPI86915.1 - 1.8 8.2 4.9 3.4 7.3 3.9 2.3 1 1 1 2 2 2 0 FAM176 family SQHop_cyclase_N PF13249.6 KPI86919.1 - 8.4e-49 166.2 0.5 8.3e-45 153.1 0.0 3.3 3 1 1 4 4 4 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 KPI86919.1 - 3.6e-38 131.5 2.0 1.6e-33 116.2 0.4 2.9 3 0 0 3 3 3 2 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 KPI86919.1 - 6.6e-24 83.3 17.2 2.6e-08 33.5 0.0 5.7 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 KPI86919.1 - 0.0026 16.8 0.0 0.0072 15.4 0.0 1.6 2 0 0 2 2 2 1 A-macroglobulin TED domain Pec_lyase PF09492.10 KPI86919.1 - 0.0079 15.6 0.1 2.5 7.3 0.0 3.7 3 1 1 4 4 4 2 Pectic acid lyase Pkinase PF00069.25 KPI86920.1 - 4.1e-47 160.8 0.0 1.5e-36 126.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86920.1 - 1.3e-30 106.6 0.0 1.8e-22 79.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase FHA PF00498.26 KPI86920.1 - 3.9e-09 36.7 0.0 9.7e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 KPI86920.1 - 0.0078 15.0 0.0 0.015 14.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KPI86920.1 - 0.028 13.7 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like MAGE PF01454.19 KPI86920.1 - 0.045 13.4 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 MAGE family RIO1 PF01163.22 KPI86920.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 KPI86920.1 - 0.33 9.8 0.0 0.51 9.2 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain SPATIAL PF15256.6 KPI86920.1 - 7.1 6.9 5.7 6.8 7.0 2.2 2.4 2 0 0 2 2 2 0 SPATIAL DUF89 PF01937.19 KPI86922.1 - 2.7e-42 145.0 0.0 2.3e-23 82.8 0.0 4.3 3 1 1 4 4 4 4 Protein of unknown function DUF89 Put_Phosphatase PF06888.12 KPI86922.1 - 1.9e-29 102.7 6.2 1.7e-15 57.0 0.1 3.2 2 1 1 3 3 3 3 Putative Phosphatase HAD PF12710.7 KPI86922.1 - 0.054 13.9 0.0 1.5 9.2 0.0 2.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Pro_CA PF00484.19 KPI86923.1 - 5.6e-41 140.4 3.1 1.2e-39 136.1 3.1 2.2 1 1 0 1 1 1 1 Carbonic anhydrase SGL PF08450.12 KPI86924.1 - 2.2e-08 34.0 0.0 7.5e-05 22.4 0.0 2.1 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 KPI86924.1 - 0.0065 16.5 0.1 0.13 12.3 0.0 2.5 2 0 0 2 2 2 1 NHL repeat Str_synth PF03088.16 KPI86924.1 - 0.052 13.7 0.0 0.58 10.3 0.0 2.2 2 0 0 2 2 2 0 Strictosidine synthase Arylesterase PF01731.20 KPI86924.1 - 0.1 12.8 0.0 0.56 10.4 0.0 1.9 2 0 0 2 2 2 0 Arylesterase Pro_CA PF00484.19 KPI86925.1 - 3.8e-41 141.0 2.4 2.3e-38 131.9 0.3 3.1 3 0 0 3 3 3 2 Carbonic anhydrase PHD PF00628.29 KPI86926.1 - 0.00015 21.6 0.6 0.00015 21.6 0.6 2.1 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 KPI86926.1 - 0.17 11.5 0.9 0.34 10.5 0.9 1.6 1 0 0 1 1 1 0 PHD-finger PHO4 PF01384.20 KPI86927.1 - 2.4e-55 188.0 4.7 3e-55 187.6 4.7 1.2 1 0 0 1 1 1 1 Phosphate transporter family DUF1861 PF08950.10 KPI86928.1 - 5.5e-116 387.0 0.0 6.4e-116 386.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) Ada_Zn_binding PF02805.16 KPI86928.1 - 0.02 14.9 0.2 0.04 13.9 0.2 1.4 1 0 0 1 1 1 0 Metal binding domain of Ada DUF1861 PF08950.10 KPI86929.1 - 2.8e-118 394.5 0.0 3.3e-118 394.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) DUF1861 PF08950.10 KPI86930.1 - 4.8e-112 374.0 0.0 5.5e-112 373.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) DUF1861 PF08950.10 KPI86931.1 - 3.5e-117 390.9 0.0 4.1e-117 390.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) DUF1861 PF08950.10 KPI86932.1 - 6.1e-120 399.9 0.1 7.2e-120 399.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) TylF PF05711.11 KPI86932.1 - 0.049 12.9 0.0 0.074 12.3 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) DUF1861 PF08950.10 KPI86933.1 - 1e-117 392.6 0.0 1.2e-117 392.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) DUF1861 PF08950.10 KPI86934.1 - 1.1e-117 392.6 0.0 1.2e-117 392.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) Methyltransf_23 PF13489.6 KPI86935.1 - 4.5e-19 68.9 0.0 7.3e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI86935.1 - 8.5e-06 26.4 0.0 0.00054 20.7 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI86935.1 - 0.00041 20.9 0.0 0.0058 17.2 0.0 2.2 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI86935.1 - 0.018 14.9 0.0 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain A2L_zn_ribbon PF08792.10 KPI86935.1 - 0.041 13.6 1.9 0.089 12.5 1.9 1.5 1 0 0 1 1 1 0 A2L zinc ribbon domain Methyltransf_25 PF13649.6 KPI86935.1 - 0.11 13.2 0.0 32 5.3 0.0 2.6 1 1 0 2 2 2 0 Methyltransferase domain DUF1989 PF09347.10 KPI86936.1 - 0.073 12.7 0.1 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1989) zf-CHY PF05495.12 KPI86936.1 - 0.3 11.6 2.7 0.19 12.2 0.7 1.7 2 0 0 2 2 2 0 CHY zinc finger OrfB_Zn_ribbon PF07282.11 KPI86937.1 - 0.054 13.4 0.4 2.6 8.0 0.1 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Atx10homo_assoc PF09759.9 KPI86938.1 - 1.6e-22 79.4 0.0 3.1e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain zf-RanBP PF00641.18 KPI86941.1 - 6.8e-11 41.3 21.3 7.6e-06 25.1 3.4 3.4 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others DZR PF12773.7 KPI86941.1 - 5.5e-06 26.3 16.0 0.0013 18.7 7.6 2.7 1 1 2 3 3 3 3 Double zinc ribbon Ima1_N PF09779.9 KPI86941.1 - 0.52 11.2 0.1 0.52 11.2 0.1 3.3 2 2 1 3 3 3 0 Ima1 N-terminal domain RIB43A PF05914.12 KPI86942.1 - 3.2e-74 249.9 67.0 4e-74 249.6 67.0 1.0 1 0 0 1 1 1 1 RIB43A SID-1_RNA_chan PF13965.6 KPI86943.1 - 0.14 10.5 0.2 0.19 10.1 0.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Babuvirus_MP PF07234.11 KPI86943.1 - 0.35 11.1 3.1 1.5 9.0 0.1 2.1 2 0 0 2 2 2 0 Movement and RNA silencing protein Ras PF00071.22 KPI86944.1 - 2.2e-46 157.4 0.0 2.6e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI86944.1 - 1.4e-26 93.1 0.0 2.3e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI86944.1 - 2.2e-06 27.2 0.0 2.8e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KPI86944.1 - 6.3e-06 25.9 0.0 0.00017 21.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KPI86944.1 - 5.6e-05 22.6 0.0 6.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI86944.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.22 KPI86945.1 - 4e-55 185.8 0.0 4.8e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI86945.1 - 3.2e-30 104.8 0.0 6.4e-30 103.8 0.0 1.5 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI86945.1 - 7.8e-11 41.7 0.0 9.8e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KPI86945.1 - 9.8e-08 31.8 0.0 6.6e-06 25.8 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI86945.1 - 1.6e-05 25.0 0.0 3.1e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KPI86945.1 - 0.00011 21.6 0.2 0.00018 21.0 0.2 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KPI86945.1 - 0.00025 21.0 0.0 0.03 14.3 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KPI86945.1 - 0.0012 19.3 0.3 0.011 16.2 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KPI86945.1 - 0.0013 19.3 0.0 0.0057 17.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI86945.1 - 0.0025 18.0 0.0 0.006 16.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 KPI86945.1 - 0.0053 16.5 0.0 0.016 14.9 0.0 1.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 KPI86945.1 - 0.022 14.5 0.2 1.5 8.5 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein SRPRB PF09439.10 KPI86945.1 - 0.024 14.1 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 KPI86945.1 - 0.05 14.1 0.0 0.14 12.6 0.0 1.9 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KPI86945.1 - 0.065 13.5 0.2 0.39 11.0 0.0 2.1 1 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KPI86945.1 - 0.07 13.5 0.0 0.17 12.3 0.0 1.7 2 0 0 2 2 2 0 RNA helicase IIGP PF05049.13 KPI86945.1 - 0.082 11.9 0.0 0.18 10.9 0.0 1.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Septin PF00735.18 KPI86945.1 - 0.087 12.1 0.1 0.17 11.1 0.0 1.4 2 0 0 2 2 2 0 Septin AAA_24 PF13479.6 KPI86945.1 - 0.11 12.2 0.0 0.43 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain TPH PF13868.6 KPI86946.1 - 2.2e-60 204.0 158.7 2.2e-60 204.0 158.7 2.0 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain zf-C3HC4_3 PF13920.6 KPI86947.1 - 5.3e-16 58.2 12.1 8e-16 57.6 12.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI86947.1 - 6.4e-09 35.5 11.7 1e-08 34.9 11.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KPI86947.1 - 2.5e-05 24.5 14.0 4.5e-05 23.7 14.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI86947.1 - 0.029 14.2 14.6 0.047 13.5 14.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI86947.1 - 0.098 12.6 12.4 0.16 12.0 12.4 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.6 KPI86947.1 - 0.64 9.9 8.3 1.2 9.0 8.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain LsmAD PF06741.13 KPI86950.1 - 6.8e-19 68.2 1.6 1.4e-18 67.2 1.6 1.6 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 KPI86950.1 - 1.3e-10 41.3 0.0 2.4e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain NTF2 PF02136.20 KPI86950.1 - 0.072 13.7 0.1 1.4 9.5 0.0 2.3 2 0 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain MARVEL PF01284.23 KPI86952.1 - 0.48 10.5 8.1 2.2 8.3 7.7 1.9 1 1 1 2 2 2 0 Membrane-associating domain NDK PF00334.19 KPI86953.1 - 7.8e-07 29.2 0.1 3.7e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 Nucleoside diphosphate kinase MIF4G PF02854.19 KPI86954.1 - 7.9e-13 48.5 2.7 7.9e-13 48.5 2.7 1.9 3 0 0 3 3 3 1 MIF4G domain Shugoshin_N PF07558.11 KPI86955.1 - 0.0044 16.9 4.3 1.5 8.7 0.3 3.7 3 0 0 3 3 3 2 Shugoshin N-terminal coiled-coil region Pox_F12L PF03337.13 KPI86955.1 - 1 7.4 7.1 1.6 6.7 7.1 1.3 1 0 0 1 1 1 0 Poxvirus F12L protein DUF5446 PF17522.2 KPI86955.1 - 5.9 7.1 12.4 0.92 9.7 4.0 3.2 2 1 0 2 2 2 0 Family of unknown function (DUF5446) Baculo_PEP_C PF04513.12 KPI86955.1 - 8.5 6.4 6.5 23 5.0 0.7 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus YABBY PF04690.13 KPI86956.1 - 0.089 13.4 0.6 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 YABBY protein Avl9 PF09794.9 KPI86956.1 - 0.23 10.1 0.0 0.31 9.7 0.0 1.2 1 0 0 1 1 1 0 Transport protein Avl9 DnaJ PF00226.31 KPI86957.1 - 2.2e-15 56.5 0.5 9e-14 51.4 0.0 3.0 3 0 0 3 3 3 1 DnaJ domain MLD PF11647.8 KPI86957.1 - 0.07 13.4 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Membrane Localization Domain 2-oxoacid_dh PF00198.23 KPI86957.1 - 0.073 12.5 0.0 3.7 6.9 0.0 2.3 2 0 0 2 2 2 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) PAP1 PF08601.10 KPI86957.1 - 1.3 8.7 5.3 0.2 11.3 1.2 1.6 2 0 0 2 2 2 0 Transcription factor PAP1 AKAP7_NLS PF10469.9 KPI86959.1 - 1.4e-19 70.9 0.0 3.4e-19 69.6 0.0 1.6 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 KPI86959.1 - 0.00029 20.8 0.7 0.0019 18.1 0.7 2.1 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily SNF2_N PF00176.23 KPI86960.1 - 2.6e-36 125.1 0.0 6.4e-36 123.8 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI86960.1 - 2.9e-11 43.7 0.0 7.1e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI86960.1 - 7e-05 22.9 0.0 0.00039 20.5 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 KPI86960.1 - 0.0028 17.3 0.0 0.0078 15.9 0.0 1.7 2 0 0 2 2 2 1 SWI2/SNF2 ATPase LRR_4 PF12799.7 KPI86962.1 - 1.4e-13 50.8 14.5 1.2e-07 31.9 1.9 3.8 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI86962.1 - 4.2e-11 42.6 2.4 3e-10 39.9 2.4 2.1 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KPI86962.1 - 2.8e-09 36.6 9.1 4.7e-07 29.5 0.5 3.0 2 1 0 3 3 3 2 Leucine rich repeat FNIP PF05725.12 KPI86962.1 - 0.019 15.1 0.0 0.25 11.5 0.0 2.4 2 1 0 2 2 2 0 FNIP Repeat LRR_1 PF00560.33 KPI86962.1 - 0.08 13.5 5.0 10 7.1 0.3 3.6 2 2 0 2 2 2 0 Leucine Rich Repeat Kelch_4 PF13418.6 KPI86963.1 - 2.8e-16 59.3 7.6 2.9e-07 30.4 0.0 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KPI86963.1 - 1.5e-15 56.8 3.2 3.5e-06 27.1 0.0 4.0 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KPI86963.1 - 2.5e-13 49.4 3.2 1.2e-06 27.9 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 KPI86963.1 - 1.7e-09 37.5 0.0 0.00044 20.2 0.0 3.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KPI86963.1 - 2.8e-08 33.9 1.0 0.091 13.1 0.0 4.0 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KPI86963.1 - 7.1e-07 29.0 0.1 0.019 14.9 0.0 4.3 4 0 0 4 4 4 2 Kelch motif F-box PF00646.33 KPI86963.1 - 0.00038 20.2 0.2 0.0011 18.8 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 KPI86963.1 - 0.00069 19.5 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like Mnd1 PF03962.15 KPI86964.1 - 6.7e-18 64.7 0.0 2.3e-17 63.0 0.0 1.9 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 KPI86964.1 - 8.3e-06 25.8 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Leucine zipper with capping helix domain FTR PF01913.18 KPI86964.1 - 0.018 15.0 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase DUF826 PF05696.11 KPI86965.1 - 0.058 13.5 1.1 0.12 12.4 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF826) RFC1 PF08519.12 KPI86966.1 - 3e-41 141.2 0.2 7e-41 140.0 0.0 1.8 2 0 0 2 2 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 KPI86966.1 - 1.1e-11 45.2 0.0 2.5e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KPI86966.1 - 1.4e-09 38.2 0.0 2.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain Zeta_toxin PF06414.12 KPI86966.1 - 0.00012 21.5 0.0 0.00023 20.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 KPI86966.1 - 0.0004 20.4 0.0 0.00094 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KPI86966.1 - 0.00066 19.7 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI86966.1 - 0.00074 19.3 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI86966.1 - 0.0015 19.0 0.0 0.0036 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI86966.1 - 0.0017 18.6 0.0 0.0061 16.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KPI86966.1 - 0.0038 17.8 0.0 0.0095 16.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 KPI86966.1 - 0.016 15.6 0.0 0.042 14.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 KPI86966.1 - 0.021 15.4 0.0 0.06 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KPI86966.1 - 0.028 14.1 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 KPI86966.1 - 0.032 14.4 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KPI86966.1 - 0.047 13.9 0.1 0.31 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KPI86966.1 - 0.062 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_3 PF07726.11 KPI86966.1 - 0.063 13.1 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 KPI86966.1 - 0.12 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region DUF3292 PF11696.8 KPI86967.1 - 2.2 6.6 4.0 5.1 5.4 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Mto2_bdg PF12808.7 KPI86969.1 - 3.6 8.0 7.6 0.49 10.7 0.2 3.1 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region RabGAP-TBC PF00566.18 KPI86970.1 - 0.00011 21.9 0.1 0.00014 21.6 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mucin-like PF16058.5 KPI86971.1 - 0.18 11.9 0.1 0.39 10.8 0.1 1.5 1 0 0 1 1 1 0 Mucin-like ANAPC4_WD40 PF12894.7 KPI86973.1 - 0.051 13.9 0.0 0.18 12.1 0.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain MTS PF05175.14 KPI86974.1 - 0.00022 20.8 0.0 0.0011 18.5 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_25 PF13649.6 KPI86974.1 - 0.013 16.1 0.2 0.04 14.6 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 KPI86974.1 - 0.034 13.9 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Fox-1_C PF12414.8 KPI86974.1 - 0.06 13.7 1.1 0.17 12.3 1.1 1.8 1 0 0 1 1 1 0 Calcitonin gene-related peptide regulator C terminal Methyltransf_11 PF08241.12 KPI86974.1 - 0.12 13.0 0.0 0.32 11.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 KPI86974.1 - 0.16 11.9 0.0 0.37 10.7 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain MCM PF00493.23 KPI86975.1 - 3.4e-87 291.2 0.0 5.3e-87 290.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KPI86975.1 - 2.7e-33 114.5 0.2 5.1e-33 113.6 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KPI86975.1 - 2.8e-24 85.4 0.3 9.2e-24 83.7 0.1 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 KPI86975.1 - 5.7e-12 46.1 0.0 1.4e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KPI86975.1 - 4.8e-07 29.4 0.0 9.4e-06 25.2 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KPI86975.1 - 0.00019 21.3 0.0 0.001 18.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KPI86975.1 - 0.00043 20.3 0.0 0.0011 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KPI86975.1 - 0.079 12.7 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain UBA PF00627.31 KPI86975.1 - 0.092 12.7 1.4 0.11 12.4 0.1 2.0 2 0 0 2 2 2 0 UBA/TS-N domain PUA PF01472.20 KPI86975.1 - 0.11 12.4 1.2 15 5.6 0.2 2.6 2 0 0 2 2 2 0 PUA domain DNA_pol_A PF00476.20 KPI86977.1 - 2.2e-49 168.5 0.1 2.6e-48 165.0 0.1 2.3 1 1 0 1 1 1 1 DNA polymerase family A EMP24_GP25L PF01105.24 KPI86979.1 - 3.1e-15 56.6 0.0 3.6e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD BclA_C PF18573.1 KPI86979.1 - 0.0024 17.8 0.1 0.14 12.1 0.0 2.1 1 1 1 2 2 2 2 BclA C-terminal domain Saf_2TM PF18303.1 KPI86979.1 - 0.031 13.9 0.6 0.057 13.0 0.2 1.6 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF202 PF02656.15 KPI86979.1 - 0.042 14.3 2.3 0.56 10.7 1.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) TIM PF00121.18 KPI86981.1 - 7.1e-88 294.1 0.7 8e-88 293.9 0.7 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase HNF-1_N PF04814.13 KPI86982.1 - 0.22 12.1 0.8 0.48 11.0 0.8 1.6 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus WW PF00397.26 KPI86984.1 - 4.1e-09 36.4 0.1 7.9e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 WW domain M11L PF11099.8 KPI86984.1 - 0.53 10.5 1.7 21 5.3 0.1 2.8 2 0 0 2 2 2 0 Apoptosis regulator M11L like ATP-synt_F PF01990.17 KPI86985.1 - 1.1e-32 112.1 0.1 1.6e-32 111.6 0.1 1.2 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit PGI PF00342.19 KPI86986.1 - 1.4e-255 848.5 1.6 1.6e-255 848.3 1.6 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Urease_beta PF00699.20 KPI86986.1 - 0.0096 15.9 0.1 0.02 14.9 0.1 1.4 1 0 0 1 1 1 1 Urease beta subunit OsmC PF02566.19 KPI86987.1 - 0.0038 17.7 0.0 0.0086 16.5 0.0 1.5 1 1 0 1 1 1 1 OsmC-like protein E3_binding PF02817.17 KPI86987.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 e3 binding domain TPR_1 PF00515.28 KPI86989.1 - 8.8e-07 28.5 8.8 0.0025 17.5 0.3 6.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86989.1 - 4.4e-05 23.3 21.9 8.6e-05 22.4 0.8 8.5 10 2 2 12 12 12 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86989.1 - 0.00013 22.4 32.2 0.13 12.8 1.2 8.1 8 1 1 10 10 10 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI86989.1 - 0.0047 17.6 1.9 0.0047 17.6 1.9 9.9 11 1 1 12 12 10 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI86989.1 - 0.0054 16.8 0.7 0.025 14.7 0.2 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 KPI86989.1 - 0.092 13.0 13.2 6 7.4 0.1 7.7 11 0 0 11 11 9 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI86989.1 - 0.19 12.0 11.2 0.21 11.8 1.9 4.3 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KPI86989.1 - 0.62 10.6 3.2 3.2 8.3 0.1 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86989.1 - 0.73 10.0 17.7 17 5.7 0.6 8.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 KPI86989.1 - 1 10.1 14.4 5.8 7.8 0.1 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86989.1 - 3.9 7.8 29.6 0.095 13.0 2.5 7.9 9 2 1 10 10 9 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI86989.1 - 8.3 6.4 6.5 29 4.7 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat FUSC_2 PF13515.6 KPI86990.1 - 3.8e-17 62.6 23.8 6.2e-16 58.7 10.4 2.6 2 0 0 2 2 2 2 Fusaric acid resistance protein-like FUSC_2 PF13515.6 KPI86991.1 - 2.3e-15 56.8 19.2 1.1e-13 51.4 4.3 2.4 2 0 0 2 2 2 2 Fusaric acid resistance protein-like ABC_membrane PF00664.23 KPI86991.1 - 1.9 8.1 7.6 1 9.0 4.2 2.1 2 0 0 2 2 2 0 ABC transporter transmembrane region Sulfatase PF00884.23 KPI86992.1 - 3.8e-05 23.2 0.1 0.00016 21.2 0.0 2.0 2 0 0 2 2 2 1 Sulfatase TPR_1 PF00515.28 KPI86993.1 - 3.3e-14 52.0 18.5 0.00035 20.2 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KPI86993.1 - 7.4e-14 50.7 6.0 0.0002 21.3 0.0 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI86993.1 - 2.2e-13 49.2 31.6 0.0011 18.9 0.1 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 KPI86993.1 - 4.3e-12 45.5 12.9 4e-05 23.2 0.3 4.3 3 1 1 4 4 4 2 TPR repeat TPR_14 PF13428.6 KPI86993.1 - 7.4e-12 45.0 15.8 0.00012 22.6 0.4 6.9 6 1 1 7 7 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 KPI86993.1 - 5.6e-11 42.8 8.1 4.9e-05 23.8 0.5 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI86993.1 - 4.3e-07 30.5 28.2 6e-05 23.6 1.4 6.0 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_15 PF13429.6 KPI86993.1 - 2.9e-06 26.7 5.8 1.4e-05 24.5 6.2 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KPI86993.1 - 3.9e-05 23.9 22.7 0.13 12.5 3.0 5.8 4 1 2 6 6 6 5 Tetratricopeptide repeat ANAPC8 PF04049.13 KPI86993.1 - 5.2e-05 23.3 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_9 PF13371.6 KPI86993.1 - 0.00051 20.1 17.4 0.23 11.7 1.2 5.5 3 2 3 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI86993.1 - 0.0013 18.9 14.6 0.057 13.7 1.0 4.6 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KPI86993.1 - 0.02 15.3 4.6 8.7 7.0 0.3 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI86993.1 - 0.082 13.0 21.4 2.1 8.5 0.2 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KPI86993.1 - 2.7 8.8 14.2 3.6 8.4 0.1 4.4 6 0 0 6 6 3 0 Tetratricopeptide repeat Pkinase PF00069.25 KPI86995.1 - 7.5e-24 84.5 0.0 8.1e-14 51.6 0.0 3.2 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI86995.1 - 2.5e-10 40.1 0.0 1.6e-08 34.2 0.0 2.9 4 0 0 4 4 4 1 Protein tyrosine kinase TT_ORF2 PF02957.15 KPI86995.1 - 0.3 12.0 1.9 3.6 8.5 0.0 3.2 2 0 0 2 2 2 0 TT viral ORF2 VRR_NUC PF08774.11 KPI86996.1 - 2.7e-07 30.6 0.0 1.2e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 VRR-NUC domain Mur_ligase_M PF08245.12 KPI86997.1 - 1.8e-10 41.2 0.1 5.8e-10 39.5 0.2 1.7 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 KPI86997.1 - 0.14 12.4 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain RCC1 PF00415.18 KPI86998.1 - 1.6e-22 79.9 11.1 4.4e-06 27.2 0.0 6.0 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI86998.1 - 8.8e-18 63.6 18.3 2.3e-07 30.4 1.2 4.6 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat His_Phos_2 PF00328.22 KPI86999.1 - 1.5e-09 37.7 0.1 0.00044 19.7 0.0 3.0 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 2) GDPD PF03009.17 KPI87000.1 - 2.4e-34 119.3 0.0 3.5e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 KPI87000.1 - 0.1 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain His_Phos_2 PF00328.22 KPI87001.1 - 9.8e-11 41.6 2.4 0.0017 17.8 0.0 3.1 1 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 2) DUF1513 PF07433.11 KPI87001.1 - 0.023 13.8 0.1 0.04 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) HEAT PF02985.22 KPI87002.1 - 0.00096 19.2 1.7 1.5 9.3 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat FAM176 PF14851.6 KPI87002.1 - 1 9.0 6.3 0.76 9.4 0.5 2.4 2 0 0 2 2 2 0 FAM176 family Silic_transp PF03842.13 KPI87003.1 - 0.045 12.1 0.0 0.068 11.5 0.0 1.2 1 0 0 1 1 1 0 Silicon transporter FA_hydroxylase PF04116.13 KPI87004.1 - 8.2e-19 68.3 10.1 8.2e-19 68.3 10.1 2.8 3 1 0 3 3 3 1 Fatty acid hydroxylase superfamily DEAD PF00270.29 KPI87005.1 - 1e-24 87.3 0.0 8.7e-24 84.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI87005.1 - 7.1e-22 77.8 0.0 9.7e-21 74.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.6 KPI87005.1 - 0.0011 19.1 0.0 0.094 12.9 0.0 2.5 3 0 0 3 3 3 1 Helicase C-terminal domain AAA_22 PF13401.6 KPI87005.1 - 0.0014 18.9 0.1 0.039 14.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 KPI87005.1 - 0.016 15.2 0.0 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SNAPc_SNAP43 PF09808.9 KPI87006.1 - 0.00035 20.5 0.0 0.0007 19.6 0.0 1.4 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Nic96 PF04097.14 KPI87007.1 - 9.9e-49 166.3 2.3 2.2e-48 165.2 2.3 1.5 1 1 0 1 1 1 1 Nup93/Nic96 HrpB1_HrpK PF09613.10 KPI87007.1 - 0.21 11.3 3.7 5.1 6.8 3.7 2.8 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) WD40 PF00400.32 KPI87008.1 - 1.5e-18 66.7 10.6 1.3e-06 29.0 0.7 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI87008.1 - 2.8e-08 34.0 0.3 2.9 8.3 0.0 5.3 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain MRI PF15325.6 KPI87008.1 - 0.082 14.0 0.8 0.33 12.1 0.8 2.0 1 0 0 1 1 1 0 Modulator of retrovirus infection DUF1283 PF06932.11 KPI87010.1 - 0.024 14.8 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) Condensation PF00668.20 KPI87010.1 - 0.2 10.3 0.6 0.26 9.9 0.6 1.1 1 0 0 1 1 1 0 Condensation domain CAP_N PF01213.19 KPI87010.1 - 2.4 7.5 10.9 4.1 6.8 10.9 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal His_Phos_2 PF00328.22 KPI87011.1 - 5.5e-08 32.6 0.2 0.00019 20.9 0.0 3.1 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 2) DUF3632 PF12311.8 KPI87012.1 - 0.042 14.3 0.2 0.11 13.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3632) PCI PF01399.27 KPI87012.1 - 0.057 13.9 0.0 0.45 11.1 0.0 2.4 3 0 0 3 3 3 0 PCI domain FYVE PF01363.21 KPI87014.1 - 2.7e-09 37.1 10.8 5.2e-09 36.1 10.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 KPI87014.1 - 0.0021 18.3 8.2 0.0037 17.5 7.5 1.8 1 1 0 1 1 1 1 FYVE-type zinc finger C1_2 PF03107.16 KPI87014.1 - 1.6 9.1 9.6 1.1 9.6 6.5 2.2 2 0 0 2 2 2 0 C1 domain SVIP PF15811.5 KPI87014.1 - 2.8 8.4 9.8 2.3 8.7 0.7 2.5 2 0 0 2 2 2 0 Small VCP/p97-interacting protein SOG2 PF10428.9 KPI87014.1 - 6.5 5.8 12.5 7.7 5.6 12.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein C1_1 PF00130.22 KPI87014.1 - 7.8 6.5 11.5 0.76 9.7 6.2 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_6 PF13912.6 KPI87014.1 - 9 6.4 9.0 14 5.8 0.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger EF-hand_7 PF13499.6 KPI87015.1 - 3.2e-08 33.9 0.0 0.00016 22.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI87015.1 - 1.7e-07 30.6 0.0 1.6e-06 27.6 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 KPI87015.1 - 3.3e-07 30.1 0.1 0.008 16.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI87015.1 - 3.5e-07 29.3 0.8 1.1e-06 27.7 0.1 2.2 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 KPI87015.1 - 3e-05 23.3 0.2 8.6e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 EF hand HMG-CoA_red PF00368.18 KPI87018.1 - 3.8e-135 450.6 4.9 4.3e-135 450.4 4.9 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase RRM_1 PF00076.22 KPI87019.1 - 1.2e-08 34.6 0.0 1.8e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI87019.1 - 0.013 15.1 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPH PF13868.6 KPI87020.1 - 5.6e-39 133.6 137.1 5.6e-39 133.6 137.1 2.1 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain TRAP_beta PF05753.14 KPI87022.1 - 3.1e-09 36.5 1.2 1.1e-08 34.7 1.2 2.0 1 1 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF11 PF01345.18 KPI87022.1 - 1.2e-08 35.1 1.8 1.8e-08 34.6 0.5 1.9 1 1 0 1 1 1 1 Domain of unknown function DUF11 CARDB PF07705.11 KPI87022.1 - 2.3e-05 24.6 0.3 3.8e-05 23.9 0.3 1.4 1 0 0 1 1 1 1 CARDB NPCBM_assoc PF10633.9 KPI87022.1 - 0.0068 16.6 0.4 0.019 15.2 0.3 1.9 1 1 0 1 1 1 1 NPCBM-associated, NEW3 domain of alpha-galactosidase TGT_C1 PF14809.6 KPI87022.1 - 0.058 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 C1 domain of tRNA-guanine transglycosylase dimerisation YfdX PF10938.8 KPI87022.1 - 0.076 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 YfdX protein Reticulon PF02453.17 KPI87022.1 - 0.087 12.8 0.5 4.8 7.1 0.1 2.1 2 0 0 2 2 2 0 Reticulon tRNA-synt_1 PF00133.22 KPI87024.1 - 2.7e-195 650.2 0.0 2.9e-194 646.7 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KPI87024.1 - 1.6e-35 122.3 0.1 2.8e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KPI87024.1 - 7.5e-16 57.9 0.6 2.7e-08 33.0 0.1 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 KPI87024.1 - 9.3e-15 54.7 2.9 2.2e-14 53.5 2.9 1.7 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.6 KPI87024.1 - 1.3e-07 31.3 0.0 0.00019 21.0 0.0 2.6 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 KPI87024.1 - 0.0048 16.3 0.2 0.37 10.1 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1b PF00579.25 KPI87024.1 - 0.13 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) SAM_decarbox PF01536.16 KPI87025.1 - 9.7e-15 54.4 0.1 6.1e-09 35.3 0.0 2.1 2 0 0 2 2 2 2 Adenosylmethionine decarboxylase SAM_decarbox PF01536.16 KPI87026.1 - 4.5e-88 295.6 0.0 5.4e-88 295.4 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase PPR_3 PF13812.6 KPI87027.1 - 0.059 13.5 0.3 0.56 10.3 0.0 2.8 5 0 0 5 5 5 0 Pentatricopeptide repeat domain Bromo_TP PF07524.13 KPI87028.1 - 0.087 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated CBFD_NFYB_HMF PF00808.23 KPI87028.1 - 0.17 12.2 0.7 5.2 7.4 0.1 2.6 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GHMP_kinases_N PF00288.26 KPI87029.1 - 3.3e-10 40.0 0.7 3.3e-10 40.0 0.7 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KPI87029.1 - 1.8e-08 34.6 0.2 4.4e-08 33.4 0.2 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal PSII_Ycf12 PF05969.11 KPI87029.1 - 0.15 12.0 0.1 0.42 10.6 0.1 1.8 1 0 0 1 1 1 0 Photosystem II complex subunit Ycf12 tRNA_m1G_MT PF01746.21 KPI87030.1 - 1.1e-17 64.4 0.3 1.8e-17 63.7 0.0 1.5 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase DUF4580 PF15162.6 KPI87030.1 - 0.038 13.6 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) Transformer PF06495.11 KPI87030.1 - 0.69 10.0 9.7 0.024 14.7 3.6 1.6 2 0 0 2 2 2 0 Fruit fly transformer protein Kinesin PF00225.23 KPI87031.1 - 8.1e-82 274.8 0.0 8.1e-82 274.8 0.0 2.9 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KPI87031.1 - 5.8e-19 68.5 0.0 2.5e-18 66.5 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding PKcGMP_CC PF16808.5 KPI87031.1 - 0.0077 16.1 0.4 0.0077 16.1 0.4 8.2 9 0 0 9 9 9 1 Coiled-coil N-terminus of cGMP-dependent protein kinase GTP_EFTU PF00009.27 KPI87031.1 - 0.19 11.2 2.0 0.55 9.7 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SNCAIP_SNCA_bd PF16700.5 KPI87031.1 - 0.5 10.1 4.0 12 5.7 1.4 3.7 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain DUF2937 PF11157.8 KPI87031.1 - 7 6.3 10.3 0.47 10.1 1.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2937) Pkinase PF00069.25 KPI87032.1 - 9.4e-67 225.1 0.0 1.4e-66 224.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87032.1 - 8.1e-45 153.1 0.0 1.3e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87032.1 - 0.004 16.5 0.0 0.013 14.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI87032.1 - 0.03 13.1 0.0 0.052 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase YrhC PF14143.6 KPI87032.1 - 0.072 13.2 1.3 15 5.7 0.1 2.8 2 0 0 2 2 2 0 YrhC-like protein FTA2 PF13095.6 KPI87032.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 eIF-3_zeta PF05091.12 KPI87033.1 - 1.5e-91 307.9 0.0 1.8e-91 307.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF21 PF01595.20 KPI87034.1 - 7.7e-28 97.4 1.9 1.5e-27 96.5 1.9 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KPI87034.1 - 2.4e-07 31.1 0.1 0.0028 18.1 0.0 3.1 3 0 0 3 3 3 2 CBS domain DUF5325 PF17259.2 KPI87034.1 - 9.2 6.2 9.2 0.12 12.3 0.6 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5325) KH_8 PF17903.1 KPI87035.1 - 2.2e-25 88.6 0.0 4.8e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain Sulfate_transp PF00916.20 KPI87036.1 - 2.8e-38 131.7 26.0 1.6e-37 129.2 26.0 2.0 1 1 0 1 1 1 1 Sulfate permease family DUF1129 PF06570.11 KPI87036.1 - 0.2 11.1 3.8 0.63 9.5 3.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) LSM PF01423.22 KPI87037.1 - 1.7e-06 27.6 0.1 2.4e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 KPI87037.1 - 0.045 13.7 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain SM-ATX PF14438.6 KPI87037.1 - 0.046 13.9 0.0 0.076 13.2 0.0 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain TPR_1 PF00515.28 KPI87038.1 - 3.2e-104 336.9 47.1 8.2e-10 38.1 0.1 15.2 15 0 0 15 15 15 14 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87038.1 - 7.7e-90 288.0 55.1 1.2e-07 31.3 0.1 15.4 15 0 0 15 15 15 15 Tetratricopeptide repeat TPR_8 PF13181.6 KPI87038.1 - 2.2e-60 195.9 33.0 0.00013 21.8 0.0 15.1 15 0 0 15 15 15 12 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87038.1 - 2.7e-59 196.6 42.4 4.2e-09 35.9 2.2 15.1 5 2 10 15 15 15 11 TPR repeat TPR_17 PF13431.6 KPI87038.1 - 9.2e-45 147.9 43.9 0.00011 22.4 0.5 14.8 15 0 0 15 15 15 9 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87038.1 - 4.9e-42 142.1 59.6 7.7e-08 32.5 4.2 11.5 6 3 6 12 12 12 11 Tetratricopeptide repeat TPR_16 PF13432.6 KPI87038.1 - 5e-40 135.9 53.0 1.5e-06 28.7 3.1 11.5 4 4 7 12 12 12 10 Tetratricopeptide repeat TPR_9 PF13371.6 KPI87038.1 - 4.2e-38 129.3 36.1 3.6e-05 23.8 0.1 11.5 3 3 6 11 11 11 10 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87038.1 - 6.3e-31 104.1 44.2 0.0086 16.0 0.1 14.2 14 0 0 14 14 14 10 Tetratricopeptide repeat TPR_6 PF13174.6 KPI87038.1 - 3.2e-27 93.3 50.1 0.055 14.1 0.1 15.2 15 0 0 15 15 15 7 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87038.1 - 4.8e-19 67.4 42.2 0.066 14.1 0.0 14.2 7 4 8 15 15 14 5 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87038.1 - 2.8e-17 63.0 31.0 0.043 14.3 0.3 9.9 4 2 6 11 11 11 9 Tetratricopeptide repeat TPR_10 PF13374.6 KPI87038.1 - 1.4e-13 50.3 58.4 0.0042 16.9 0.1 14.5 16 0 0 16 16 16 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI87038.1 - 9.9e-08 32.1 41.8 0.078 13.2 1.5 7.3 5 3 3 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 KPI87038.1 - 5.7e-07 30.1 22.3 0.042 14.3 3.7 5.7 4 2 1 5 5 5 2 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 KPI87038.1 - 4.1e-06 26.1 24.1 6.3 6.3 0.1 11.1 12 0 0 12 12 12 1 SHNi-TPR MIT PF04212.18 KPI87038.1 - 1.9e-05 24.6 25.1 2.2 8.4 0.0 9.7 10 0 0 10 10 10 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 KPI87038.1 - 0.0023 18.0 13.8 8.5 6.4 0.2 7.7 5 4 1 7 7 7 0 Domain of Unknown Function (DUF3856) Fis1_TPR_C PF14853.6 KPI87038.1 - 0.018 15.1 26.6 5.9 7.1 0.1 8.4 7 2 2 9 9 9 0 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.8 KPI87038.1 - 0.02 13.8 14.7 0.24 10.3 0.1 5.0 2 2 2 5 5 5 0 NMDA receptor-regulated protein 1 Paf67 PF10255.9 KPI87038.1 - 0.051 12.6 13.6 0.19 10.7 0.4 5.3 4 1 2 6 6 6 0 RNA polymerase I-associated factor PAF67 Coatomer_E PF04733.14 KPI87038.1 - 0.085 12.3 1.5 2.3 7.5 0.0 3.8 3 1 1 5 5 5 0 Coatomer epsilon subunit TPR_4 PF07721.14 KPI87038.1 - 0.81 10.5 21.4 26 5.8 0.1 9.1 11 0 0 11 11 8 0 Tetratricopeptide repeat DUF2817 PF10994.8 KPI87040.1 - 3.9e-97 325.7 0.3 4.6e-97 325.5 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) His_Phos_2 PF00328.22 KPI87041.1 - 7.8e-12 45.2 5.8 1.6e-08 34.3 0.1 3.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Pkinase PF00069.25 KPI87042.1 - 6.3e-61 206.0 0.0 7.5e-61 205.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87042.1 - 2.9e-26 92.3 0.0 3.9e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87042.1 - 7.5e-10 38.6 0.1 1.8e-09 37.4 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI87042.1 - 0.00015 21.2 0.6 0.0003 20.2 0.6 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI87042.1 - 0.02 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 KPI87042.1 - 0.043 13.7 0.2 0.29 11.0 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI87042.1 - 0.093 11.7 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 KPI87042.1 - 0.11 12.0 0.1 0.37 10.4 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4407 PF14362.6 KPI87043.1 - 0.25 10.7 8.0 0.36 10.1 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Topoisom_I PF01028.20 KPI87046.1 - 0.12 11.6 0.5 0.25 10.5 0.1 1.7 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, catalytic core Sec23_trunk PF04811.15 KPI87048.1 - 2.3e-51 174.7 0.0 4.6e-51 173.7 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KPI87048.1 - 1.1e-21 77.4 0.2 1.1e-21 77.4 0.2 2.0 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KPI87048.1 - 2.5e-21 75.4 0.1 9.1e-21 73.6 0.1 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KPI87048.1 - 4.1e-11 42.7 0.8 8.6e-11 41.7 0.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KPI87048.1 - 1.1e-05 25.2 2.1 1.5e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Gelsolin repeat VWA_2 PF13519.6 KPI87048.1 - 0.033 14.8 0.0 1.3 9.7 0.0 2.8 2 0 0 2 2 2 0 von Willebrand factor type A domain Vps36-NZF-N PF16988.5 KPI87048.1 - 0.12 11.8 0.1 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain TFIIA PF03153.13 KPI87048.1 - 4.3 7.2 17.1 8.1 6.3 17.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TB2_DP1_HVA22 PF03134.19 KPI87049.1 - 0.0029 17.5 1.0 0.0046 16.9 1.0 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family HU-CCDC81_euk_2 PF18289.1 KPI87050.1 - 1.6e-09 37.8 0.0 3e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 KPI87050.1 - 0.13 12.4 0.0 2.6 8.3 0.0 2.4 2 0 0 2 2 2 0 CCDC81 eukaryotic HU domain 1 Ribosomal_S8e PF01201.22 KPI87052.1 - 2.9e-43 147.3 7.8 5.5e-43 146.4 7.8 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e DUF3746 PF12562.8 KPI87052.1 - 0.074 13.0 0.6 0.41 10.6 0.2 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3746) CCDC-167 PF15188.6 KPI87052.1 - 0.19 12.1 2.5 0.41 11.0 2.5 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Ribosomal_L26 PF16906.5 KPI87052.1 - 0.22 12.0 7.1 3.8 8.1 3.1 2.4 2 0 0 2 2 2 0 Ribosomal proteins L26 eukaryotic, L24P archaeal MTHFR PF02219.17 KPI87053.1 - 2.5e-92 309.3 0.0 3e-92 309.0 0.0 1.0 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1126 PF06565.12 KPI87054.1 - 1.1e-63 211.6 0.1 1.3e-22 79.6 0.1 3.5 3 0 0 3 3 3 3 DUF1126 PH-like domain EF-hand_8 PF13833.6 KPI87054.1 - 5.5e-08 32.5 0.1 0.0033 17.2 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 KPI87054.1 - 2.2e-06 28.0 0.1 4.1e-05 23.9 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain pair Mac-1 PF09028.10 KPI87054.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Mac 1 EF-hand_1 PF00036.32 KPI87054.1 - 0.15 11.7 0.4 2 8.1 0.1 2.9 2 0 0 2 2 2 0 EF hand RabGAP-TBC PF00566.18 KPI87055.1 - 1.9e-13 50.6 0.4 2.8e-13 50.0 0.4 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Tma16 PF11176.8 KPI87058.1 - 8.9e-21 74.3 4.7 1.1e-20 74.0 0.1 2.1 2 0 0 2 2 2 1 Translation machinery-associated protein 16 CAF1 PF04857.20 KPI87059.1 - 3e-68 230.3 0.7 3.8e-68 230.0 0.7 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.20 KPI87059.1 - 0.0059 16.3 0.0 0.23 11.1 0.0 2.6 3 0 0 3 3 3 1 3'-5' exonuclease PH_11 PF15413.6 KPI87060.1 - 0.01 16.2 0.0 0.032 14.7 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain TrbC PF04956.13 KPI87061.1 - 0.011 15.9 6.2 0.013 15.7 6.2 1.1 1 0 0 1 1 1 0 TrbC/VIRB2 family DUF1206 PF06724.11 KPI87061.1 - 0.015 15.3 4.3 0.018 15.1 4.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) ATP-synt_S1 PF05827.12 KPI87061.1 - 0.099 12.5 0.8 0.11 12.3 0.8 1.2 1 1 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) B12D PF06522.11 KPI87061.1 - 2.4 8.0 3.4 3.1 7.6 0.1 2.0 1 1 1 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit TFIIB PF00382.19 KPI87062.1 - 0.11 12.5 3.7 7 6.8 0.1 2.4 2 0 0 2 2 2 0 Transcription factor TFIIB repeat HECT PF00632.25 KPI87063.1 - 8.9e-51 173.2 0.0 1.4e-50 172.5 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 KPI87063.1 - 9.4e-36 122.6 0.0 5.4e-15 55.6 0.0 3.7 3 0 0 3 3 3 3 SPRY domain Laminin_G_3 PF13385.6 KPI87063.1 - 7.5e-20 71.6 0.0 4e-10 40.0 0.0 3.6 4 0 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily TFIIF_alpha PF05793.12 KPI87063.1 - 0.33 9.5 5.9 0.53 8.8 5.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 KPI87063.1 - 9.2 4.2 10.9 17 3.4 10.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi PI3_PI4_kinase PF00454.27 KPI87065.1 - 2.2e-63 214.4 0.0 4.7e-63 213.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 KPI87065.1 - 2.8e-53 181.4 1.3 7.5e-53 179.9 1.3 1.8 1 0 0 1 1 1 1 FAT domain DUF3385 PF11865.8 KPI87065.1 - 2.7e-23 82.7 1.1 9.2e-21 74.4 0.2 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 KPI87065.1 - 3.5e-20 72.2 0.7 3.5e-20 72.2 0.7 3.1 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain FATC PF02260.20 KPI87065.1 - 2.8e-15 55.8 0.3 7.7e-15 54.4 0.3 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 KPI87065.1 - 5.6e-06 26.7 7.0 1.7 9.1 0.3 6.3 5 0 0 5 5 5 2 HEAT repeats MMS19_N PF14500.6 KPI87065.1 - 0.0019 17.8 4.8 0.085 12.4 0.1 4.3 4 0 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II BP28CT PF08146.12 KPI87065.1 - 0.0021 17.9 0.0 2.9 7.7 0.0 3.7 3 0 0 3 3 3 1 BP28CT (NUC211) domain CLASP_N PF12348.8 KPI87065.1 - 0.051 13.1 0.6 1.7 8.2 0.0 3.8 4 0 0 4 4 4 0 CLASP N terminal RIX1 PF08167.12 KPI87065.1 - 0.062 13.0 8.2 0.32 10.7 0.3 4.9 4 1 0 4 4 4 0 rRNA processing/ribosome biogenesis UME PF08064.13 KPI87065.1 - 0.094 12.6 1.3 19 5.2 0.0 4.2 4 0 0 4 4 4 0 UME (NUC010) domain HEAT_EZ PF13513.6 KPI87065.1 - 2.6 8.6 13.0 16 6.1 0.1 6.5 6 0 0 6 6 5 0 HEAT-like repeat FANCI_S2 PF14676.6 KPI87065.1 - 8.5 6.7 7.8 44 4.3 0.1 5.0 4 1 1 5 5 5 0 FANCI solenoid 2 S-methyl_trans PF02574.16 KPI87066.1 - 8.7e-72 242.1 0.0 9.9e-72 242.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase FliG_M PF14841.6 KPI87066.1 - 0.013 15.7 0.5 1.9 8.7 0.3 2.5 2 0 0 2 2 2 0 FliG middle domain HEPN_SAV_6107 PF18726.1 KPI87066.1 - 0.032 14.8 0.6 0.069 13.7 0.6 1.6 1 0 0 1 1 1 0 SAV_6107-like HEPN PEP_mutase PF13714.6 KPI87066.1 - 0.075 12.5 0.2 10 5.5 0.0 2.6 3 0 0 3 3 3 0 Phosphoenolpyruvate phosphomutase Metallophos PF00149.28 KPI87067.1 - 7.6e-15 56.0 0.0 1.3e-12 48.6 0.0 3.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI87067.1 - 0.088 13.3 0.0 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain Ribosomal_60s PF00428.19 KPI87069.1 - 0.019 15.6 1.0 0.019 15.6 1.0 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein FAM176 PF14851.6 KPI87069.1 - 0.72 9.5 5.3 0.99 9.1 0.2 2.2 2 0 0 2 2 2 0 FAM176 family Methyltransf_11 PF08241.12 KPI87070.1 - 7.4e-10 39.3 0.0 6.7e-05 23.5 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain WBS_methylT PF12589.8 KPI87070.1 - 8.9e-10 39.2 9.5 8.9e-10 39.2 9.5 1.9 2 0 0 2 2 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 KPI87070.1 - 7.7e-09 36.1 0.0 1.3e-05 25.8 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KPI87070.1 - 4.3e-06 27.4 0.0 0.00017 22.3 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI87070.1 - 6.6e-06 26.1 0.0 9.7e-06 25.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI87070.1 - 2.3e-05 24.3 0.0 0.0013 18.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain AdoMet_MTase PF07757.13 KPI87070.1 - 0.0063 16.8 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 KPI87070.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 KPI87070.1 - 0.12 12.1 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MFS_1 PF07690.16 KPI87073.1 - 4.3e-26 91.7 27.8 1.4e-14 53.8 6.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KPI87073.1 - 0.05 12.0 14.2 0.011 14.2 4.5 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector RRM_1 PF00076.22 KPI87075.1 - 7.1e-12 45.0 0.0 1.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4140 PF13600.6 KPI87076.1 - 0.46 10.9 7.3 0.2 12.1 2.3 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FlxA PF14282.6 KPI87076.1 - 0.99 9.4 7.7 0.15 12.1 0.2 2.5 2 0 0 2 2 2 0 FlxA-like protein TMF_DNA_bd PF12329.8 KPI87076.1 - 4 7.5 5.4 0.65 10.0 0.1 2.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding WD40 PF00400.32 KPI87077.1 - 5.6e-15 55.5 6.1 0.00069 20.4 0.9 7.1 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI87077.1 - 2.6e-05 24.4 0.1 0.16 12.3 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain UPF0126 PF03458.13 KPI87077.1 - 0.017 15.0 0.8 0.046 13.6 0.8 1.6 1 0 0 1 1 1 0 UPF0126 domain Tmemb_40 PF10160.9 KPI87077.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein FAD_binding_1 PF00667.20 KPI87078.1 - 5.3e-32 111.2 0.0 7.3e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KPI87078.1 - 2.4e-19 70.0 0.0 4.8e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KPI87078.1 - 5.7e-15 55.9 0.0 1e-14 55.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Vps52 PF04129.12 KPI87079.1 - 4.5e-16 58.7 4.0 1.9e-15 56.6 2.5 2.1 2 0 0 2 2 2 1 Vps52 / Sac2 family Dor1 PF04124.12 KPI87079.1 - 0.015 14.0 2.3 0.038 12.7 2.3 1.6 1 0 0 1 1 1 0 Dor1-like family DUF2935 PF11155.8 KPI87079.1 - 0.049 14.0 2.0 16 5.8 0.0 3.9 4 1 0 4 4 4 0 Domain of unknown function (DUF2935) COG2 PF06148.11 KPI87079.1 - 0.073 13.2 1.5 0.24 11.5 1.5 1.9 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 T4SS PF07996.11 KPI87079.1 - 0.21 12.0 5.7 0.13 12.6 3.1 2.0 2 0 0 2 2 2 0 Type IV secretion system proteins DUF21 PF01595.20 KPI87080.1 - 2.3e-33 115.4 0.6 4.3e-33 114.5 0.6 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KPI87080.1 - 2.4e-06 27.9 0.0 0.0064 16.9 0.0 2.5 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 KPI87080.1 - 0.046 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain Bac_rhodopsin PF01036.18 KPI87080.1 - 0.15 11.6 3.7 6.6 6.2 0.9 2.2 2 0 0 2 2 2 0 Bacteriorhodopsin-like protein Whib PF02467.16 KPI87081.1 - 0.015 15.9 0.1 0.07 13.7 0.1 2.2 1 0 0 1 1 1 0 Transcription factor WhiB DDE_Tnp_1_6 PF13751.6 KPI87081.1 - 0.12 12.7 0.3 25 5.1 0.1 2.4 2 0 0 2 2 2 0 Transposase DDE domain PhoLip_ATPase_C PF16212.5 KPI87082.1 - 2.4e-45 155.3 21.3 2.4e-45 155.3 21.3 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KPI87082.1 - 4.3e-25 87.2 0.7 1e-24 86.0 0.7 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KPI87082.1 - 1.2e-12 48.6 0.2 1.3e-06 28.9 0.5 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KPI87082.1 - 1e-08 35.1 0.0 4e-07 30.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KPI87082.1 - 0.00022 20.8 0.1 0.0016 18.0 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KPI87082.1 - 0.0019 18.0 0.0 0.0052 16.6 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI87082.1 - 0.12 12.8 0.0 14 6.0 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KPI87082.1 - 0.19 11.8 0.0 0.46 10.6 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase BT1 PF03092.16 KPI87083.1 - 4.8e-176 586.1 8.8 5.5e-176 585.8 8.8 1.0 1 0 0 1 1 1 1 BT1 family Ost5 PF05251.12 KPI87083.1 - 6.8 7.0 13.7 1.3 9.3 0.4 3.6 4 0 0 4 4 4 0 Oligosaccharyltransferase subunit 5 SUV3_C PF12513.8 KPI87084.1 - 1.5e-09 37.6 1.1 3.3e-09 36.5 0.2 2.1 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 KPI87084.1 - 3.5e-07 30.0 0.0 1.3e-06 28.1 0.0 2.1 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 KPI87084.1 - 9.7e-06 25.9 0.0 2.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI87084.1 - 0.048 13.4 0.0 0.17 11.6 0.0 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase Kinesin PF00225.23 KPI87084.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain ATPase_2 PF01637.18 KPI87084.1 - 0.26 11.2 0.0 0.83 9.5 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 KPI87085.1 - 3.2e-157 523.2 1.6 3.5e-157 523.1 0.3 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 KPI87085.1 - 1.3e-23 82.9 0.4 3.2e-23 81.6 0.4 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KPI87085.1 - 3.1e-09 37.4 1.0 7.7e-06 26.4 0.1 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KPI87085.1 - 1.5e-07 31.3 0.4 0.00012 21.8 0.0 2.7 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KPI87085.1 - 2.5e-06 27.8 0.1 0.15 12.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KPI87085.1 - 4.4e-06 27.2 0.3 0.00014 22.3 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain DnaB_C PF03796.15 KPI87085.1 - 1.3e-05 24.7 0.2 2.3e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 KPI87085.1 - 3.9e-05 23.1 1.2 0.00078 18.9 0.5 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KPI87085.1 - 4.5e-05 23.5 0.4 0.0095 15.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 KPI87085.1 - 4.5e-05 23.8 4.1 0.00016 22.1 1.0 2.7 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KPI87085.1 - 0.0027 17.0 0.2 0.0073 15.6 0.2 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 KPI87085.1 - 0.0034 17.8 0.2 0.026 15.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 KPI87085.1 - 0.0042 16.8 0.0 1.6 8.4 0.1 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 KPI87085.1 - 0.0099 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 KPI87085.1 - 0.014 15.2 0.2 0.074 12.9 0.0 2.3 3 0 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein ATPase PF06745.13 KPI87085.1 - 0.019 14.3 0.3 0.053 12.9 0.1 1.7 1 1 0 1 1 1 0 KaiC AAA_25 PF13481.6 KPI87085.1 - 0.032 13.8 0.1 0.093 12.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KPI87085.1 - 0.038 13.7 0.1 0.084 12.6 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein GATase PF00117.28 KPI87085.1 - 0.048 13.4 0.1 0.83 9.4 0.0 2.2 2 0 0 2 2 2 0 Glutamine amidotransferase class-I DUF2075 PF09848.9 KPI87085.1 - 0.049 12.9 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 KPI87085.1 - 0.065 12.9 1.0 1.3 8.7 0.1 2.8 3 0 0 3 3 3 0 AAA domain Sigma54_activ_2 PF14532.6 KPI87085.1 - 0.077 13.1 0.0 0.78 9.8 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 KPI87085.1 - 0.089 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 KPI87085.1 - 0.094 12.2 0.4 0.37 10.3 0.1 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 KPI87085.1 - 0.095 12.5 0.1 0.56 10.0 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 KPI87085.1 - 0.11 12.5 0.7 0.3 11.1 0.1 2.0 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KPI87085.1 - 0.15 12.6 0.3 0.38 11.3 0.0 1.8 2 1 0 2 2 1 0 ABC transporter ACBP PF00887.19 KPI87086.1 - 1e-13 51.3 0.9 1.2e-13 51.1 0.9 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Adap_comp_sub PF00928.21 KPI87087.1 - 5e-58 196.5 0.0 6.1e-58 196.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KPI87087.1 - 0.011 15.6 0.1 0.017 15.1 0.1 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Alba PF01918.21 KPI87088.1 - 1.7e-17 62.9 0.2 2.5e-17 62.5 0.2 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 KPI87088.1 - 0.00046 20.2 0.2 0.00095 19.1 0.2 1.6 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P GRP PF07172.11 KPI87088.1 - 2.3 9.0 21.1 0.046 14.4 12.6 2.1 2 1 0 2 2 2 0 Glycine rich protein family zf-CCCH_6 PF18585.1 KPI87089.1 - 0.63 10.0 6.3 3.7 7.5 0.3 3.7 2 1 1 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DUF4265 PF14085.6 KPI87089.1 - 1.1 9.2 6.3 1.9 8.5 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4265) SlyX PF04102.12 KPI87090.1 - 0.065 13.9 2.6 0.12 13.0 0.2 2.5 2 1 1 3 3 3 0 SlyX DNase-RNase PF02577.14 KPI87090.1 - 0.078 12.6 1.6 0.12 12.0 1.6 1.4 1 0 0 1 1 1 0 Bifunctional nuclease TPR_MLP1_2 PF07926.12 KPI87090.1 - 0.23 11.5 8.8 0.066 13.3 1.4 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Hexapep PF00132.24 KPI87091.1 - 3.3e-10 39.3 7.1 3.3e-08 32.9 1.6 3.4 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KPI87091.1 - 6e-08 32.3 5.4 4.1e-07 29.6 0.4 3.1 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase HECT PF00632.25 KPI87092.1 - 3.5e-38 131.8 1.6 3.9e-38 131.7 0.2 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 KPI87092.1 - 7.8e-20 71.2 0.5 4.5e-05 23.6 0.0 5.8 6 0 0 6 6 6 4 SPRY domain GATA PF00320.27 KPI87092.1 - 8.5 6.1 7.8 9.8 5.9 1.9 2.8 2 0 0 2 2 2 0 GATA zinc finger Asp PF00026.23 KPI87093.1 - 1.2e-80 271.3 0.0 1.4e-80 271.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KPI87093.1 - 5.8e-10 39.7 0.2 9.1e-07 29.3 0.1 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KPI87093.1 - 7.7e-06 25.8 0.0 6.9e-05 22.7 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 KPI87093.1 - 0.028 15.1 0.1 3.1 8.5 0.2 2.8 2 1 0 2 2 2 0 Aspartyl protease DAGK_acc PF00609.19 KPI87095.1 - 1.9e-37 129.0 0.0 2.7e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KPI87095.1 - 6.5e-16 58.1 0.0 1.1e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 KPI87095.1 - 0.048 12.9 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 ATP-NAD kinase YqgF PF14639.6 KPI87095.1 - 0.19 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Aa_trans PF01490.18 KPI87096.1 - 1.9e-51 175.1 33.8 2.2e-51 174.8 33.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI87096.1 - 0.00018 20.7 17.3 0.00018 20.7 17.3 1.9 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 KPI87097.1 - 9.2e-52 176.1 31.2 1e-51 175.9 31.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2838 PF10998.8 KPI87097.1 - 0.034 14.4 0.7 0.034 14.4 0.7 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF2838) DUF3850 PF12961.7 KPI87097.1 - 0.15 12.1 0.1 0.27 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) Dynein_heavy PF03028.15 KPI87098.1 - 2.4e-08 34.1 0.0 4.1e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain Ank_2 PF12796.7 KPI87098.1 - 5.7e-07 30.0 0.0 1.8e-06 28.4 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI87098.1 - 0.00037 21.0 0.0 3.1 8.5 0.0 4.2 5 1 0 6 6 6 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI87098.1 - 0.0027 18.1 0.0 0.026 14.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KPI87098.1 - 0.027 15.0 0.0 0.86 10.4 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 KPI87098.1 - 0.082 13.3 0.0 0.85 10.0 0.0 2.6 3 0 0 3 3 3 0 Ankyrin repeats (many copies) FMN_dh PF01070.18 KPI87099.1 - 1.8e-27 96.3 0.1 1.9e-18 66.6 0.3 2.2 2 0 0 2 2 2 2 FMN-dependent dehydrogenase Glu_synthase PF01645.17 KPI87099.1 - 1.1e-05 24.8 0.9 3.8e-05 23.0 0.9 1.7 1 1 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 KPI87099.1 - 2.2e-05 23.7 1.9 5.2e-05 22.4 0.2 2.1 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 KPI87099.1 - 0.077 12.4 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase His_biosynth PF00977.21 KPI87099.1 - 0.083 12.3 0.1 0.26 10.7 0.0 1.8 2 0 0 2 2 2 0 Histidine biosynthesis protein SAC3_GANP PF03399.16 KPI87100.1 - 4.2e-15 55.9 2.7 2.3e-13 50.2 2.7 2.3 1 1 0 1 1 1 1 SAC3/GANP family MMR_HSR1_Xtn PF16897.5 KPI87101.1 - 8.4e-36 122.2 0.9 1.4e-35 121.5 0.9 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KPI87101.1 - 1.9e-23 82.3 0.1 4.3e-23 81.1 0.1 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KPI87101.1 - 1.2e-17 64.0 0.0 2.8e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI87101.1 - 7.5e-09 35.3 0.0 1.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KPI87101.1 - 0.007 16.4 0.2 1.8 8.6 0.0 2.4 1 1 0 2 2 2 2 Dynamin family Roc PF08477.13 KPI87101.1 - 0.064 13.5 0.4 0.75 10.0 0.0 2.8 3 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI87101.1 - 0.13 11.9 0.2 1.7 8.2 0.2 2.3 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 KPI87101.1 - 0.14 11.6 0.2 0.32 10.4 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AD PF09793.9 KPI87103.1 - 0.036 14.2 0.0 0.06 13.5 0.0 1.4 1 0 0 1 1 1 0 Anticodon-binding domain WD40 PF00400.32 KPI87105.1 - 7.8e-11 42.4 5.1 0.0023 18.7 0.1 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat HALZ PF02183.18 KPI87106.1 - 7.7e-06 26.0 0.6 1.4e-05 25.2 0.6 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF1640 PF07798.11 KPI87106.1 - 0.0035 17.4 0.3 0.0042 17.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Fungal_TACC PF12709.7 KPI87106.1 - 0.0037 17.7 0.5 0.0055 17.1 0.2 1.4 1 1 0 1 1 1 1 Fungal Transforming acidic coiled-coil (TACC) proteins DivIC PF04977.15 KPI87106.1 - 0.02 14.7 2.4 0.02 14.7 2.4 1.9 2 0 0 2 2 2 0 Septum formation initiator ZapB PF06005.12 KPI87106.1 - 0.024 15.1 2.6 0.024 15.1 2.6 1.8 2 1 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 KPI87106.1 - 0.027 14.6 0.4 0.027 14.6 0.4 1.9 2 0 0 2 2 2 0 bZIP transcription factor DASH_Spc34 PF08657.10 KPI87106.1 - 0.031 14.1 0.7 0.033 14.0 0.7 1.1 1 0 0 1 1 1 0 DASH complex subunit Spc34 Dpy-30 PF05186.13 KPI87106.1 - 0.06 13.1 0.2 0.16 11.7 0.2 1.7 1 1 0 1 1 1 0 Dpy-30 motif ALG11_N PF15924.5 KPI87107.1 - 2.2e-60 204.3 0.1 3.6e-60 203.6 0.1 1.3 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 KPI87107.1 - 7e-23 81.0 0.0 9.7e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KPI87107.1 - 8.7e-13 48.9 0.1 1.7e-12 47.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KPI87107.1 - 0.00037 20.8 0.0 0.00092 19.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Rho_N PF07498.12 KPI87107.1 - 0.0023 17.8 0.1 0.0039 17.1 0.1 1.3 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain Methyltransf_4 PF02390.17 KPI87109.1 - 3.6e-37 127.5 0.0 4.5e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 KPI87109.1 - 0.0018 18.1 0.0 0.0034 17.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI87109.1 - 0.0024 18.6 0.0 0.014 16.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI87109.1 - 0.0034 18.0 0.0 0.019 15.7 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Transpos_assoc PF13963.6 KPI87109.1 - 0.084 13.2 0.0 0.27 11.6 0.0 1.9 2 0 0 2 2 2 0 Transposase-associated domain Tup_N PF08581.10 KPI87110.1 - 0.048 14.0 8.2 0.23 11.8 1.0 3.8 3 1 0 3 3 3 0 Tup N-terminal TOH_N PF12549.8 KPI87110.1 - 1.4 8.8 6.2 6 6.9 0.7 2.7 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal CEP63 PF17045.5 KPI87110.1 - 2.4 8.0 17.5 2.6 7.9 1.4 3.8 3 1 1 4 4 4 0 Centrosomal protein of 63 kDa CdvA PF18822.1 KPI87110.1 - 2.9 7.8 7.4 0.84 9.5 0.5 3.2 3 1 0 3 3 3 0 CdvA-like coiled-coil domain JIP_LZII PF16471.5 KPI87110.1 - 5.6 7.2 12.5 3.5 7.9 0.2 4.4 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II HalX PF08663.10 KPI87110.1 - 9.1 6.7 24.9 1.9 8.8 1.3 4.5 4 2 0 4 4 4 0 HalX domain MMR_HSR1 PF01926.23 KPI87111.1 - 6.9e-13 48.7 0.0 1.4e-11 44.4 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI87111.1 - 2.2e-06 27.7 0.0 2e-05 24.6 0.0 2.1 1 1 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 KPI87111.1 - 0.0046 17.2 0.0 0.015 15.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain FeoB_N PF02421.18 KPI87111.1 - 0.02 14.4 0.1 0.049 13.2 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 KPI87111.1 - 0.065 13.3 0.6 3.4 7.7 0.0 2.5 1 1 1 2 2 2 0 Dynamin family Septin PF00735.18 KPI87111.1 - 0.12 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_16 PF13191.6 KPI87111.1 - 0.17 12.2 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain zf-CCCH_3 PF15663.5 KPI87113.1 - 4e-05 23.8 1.7 8.6e-05 22.7 1.7 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH PF00642.24 KPI87113.1 - 0.00017 21.4 7.4 0.0064 16.4 0.3 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KPI87113.1 - 0.057 13.9 12.8 0.83 10.2 1.9 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger MA3 PF02847.17 KPI87114.1 - 0.096 12.7 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 MA3 domain MMR_HSR1 PF01926.23 KPI87115.1 - 0.0023 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 KPI87115.1 - 0.038 13.4 0.1 0.097 12.0 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.6 KPI87116.1 - 1.5e-05 25.6 0.1 9.5e-05 22.9 0.0 2.2 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 KPI87116.1 - 0.016 15.4 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KPI87116.1 - 0.074 12.8 0.2 0.43 10.3 0.0 2.3 3 0 0 3 3 3 0 Cytidylate kinase AAA_33 PF13671.6 KPI87116.1 - 0.082 13.1 0.0 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain ANAPC2 PF08672.11 KPI87116.1 - 0.25 11.9 1.3 13 6.4 0.1 3.1 3 0 0 3 3 3 0 Anaphase promoting complex (APC) subunit 2 MFS_1 PF07690.16 KPI87117.1 - 5e-19 68.4 45.5 8.9e-18 64.3 22.0 2.3 2 1 0 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.13 KPI87117.1 - 1.3e-07 31.4 17.4 1.3e-07 31.4 17.4 2.9 2 2 0 2 2 2 1 Nodulin-like TssO PF17561.2 KPI87117.1 - 0.49 10.5 0.1 0.49 10.5 0.1 3.1 4 0 0 4 4 4 0 Type VI secretion system, TssO Nuc_deoxyrib_tr PF05014.15 KPI87118.1 - 2e-35 121.6 0.0 2.4e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase DUF4406 PF14359.6 KPI87118.1 - 0.12 12.9 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4406) Beach PF02138.18 KPI87119.1 - 1.9e-89 299.7 0.0 2.5e-89 299.3 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain DNA_meth_N PF18284.1 KPI87119.1 - 0.26 11.2 1.2 1.3 9.0 0.2 2.4 2 0 0 2 2 2 0 DNA methylase N-terminal domain NRDE-2 PF08424.10 KPI87122.1 - 3.3e-06 26.4 1.0 0.00017 20.8 0.3 3.6 3 1 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 KPI87122.1 - 0.00051 20.6 23.2 26 6.0 0.3 9.4 8 1 2 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI87122.1 - 2.2 9.0 13.3 9.8 6.9 0.4 5.6 4 1 1 5 5 5 0 Tetratricopeptide repeat DP PF08781.10 KPI87124.1 - 0.51 10.2 2.2 1.3 8.9 2.2 1.7 1 0 0 1 1 1 0 Transcription factor DP HAUS6_N PF14661.6 KPI87124.1 - 1.6 8.2 5.0 8.9 5.8 5.1 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus UbiA PF01040.18 KPI87125.1 - 8.5e-50 169.4 18.2 1.2e-49 168.9 18.2 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF2101 PF09874.9 KPI87125.1 - 0.62 9.7 2.3 14 5.3 0.4 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2101) V_ATPase_I PF01496.19 KPI87126.1 - 6.7e-261 867.8 20.5 2.3e-177 591.5 0.7 3.0 1 1 1 3 3 3 3 V-type ATPase 116kDa subunit family DUF16 PF01519.16 KPI87126.1 - 0.12 12.9 2.7 0.43 11.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF1902 PF08972.11 KPI87126.1 - 0.18 11.8 0.1 24 5.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) zf-LITAF-like PF10601.9 KPI87126.1 - 0.66 10.3 3.3 0.64 10.3 0.2 2.4 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain GARP PF16731.5 KPI87126.1 - 0.85 9.3 4.1 0.27 10.9 0.8 1.8 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma ZapB PF06005.12 KPI87126.1 - 2.9 8.4 6.9 0.47 10.9 1.3 2.3 2 0 0 2 2 2 0 Cell division protein ZapB Occludin_ELL PF07303.13 KPI87126.1 - 2.9 8.7 4.6 22 5.8 0.1 3.1 3 0 0 3 3 3 0 Occludin homology domain CLZ PF16526.5 KPI87126.1 - 9.1 6.7 7.7 1.5 9.2 0.4 2.7 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels LRR_8 PF13855.6 KPI87128.1 - 1.6e-11 43.8 9.5 0.012 15.4 0.3 5.8 4 3 2 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 KPI87128.1 - 8.3e-09 35.6 10.0 0.036 14.5 0.2 5.4 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI87128.1 - 8.5e-05 22.6 9.8 5.3 8.0 0.3 6.0 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 KPI87128.1 - 0.0025 17.7 6.5 15 6.0 0.0 5.5 6 0 0 6 6 6 1 Leucine Rich repeat Ala_racemase_N PF01168.20 KPI87129.1 - 8.4e-21 74.6 0.0 1.1e-20 74.3 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain LRR_4 PF12799.7 KPI87130.1 - 3.6e-06 27.2 0.4 0.052 14.0 0.0 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87130.1 - 3.9e-05 23.3 0.6 0.11 12.3 0.0 2.6 1 1 0 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 KPI87130.1 - 7.7e-05 22.3 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat Ribosomal_60s PF00428.19 KPI87130.1 - 0.025 15.1 7.4 0.046 14.3 7.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein LRR_6 PF13516.6 KPI87130.1 - 0.052 13.6 0.1 2.3 8.5 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich repeat SDA1 PF05285.12 KPI87130.1 - 0.17 11.3 8.3 0.23 10.8 8.3 1.2 1 0 0 1 1 1 0 SDA1 HSP90 PF00183.18 KPI87130.1 - 0.25 10.2 4.8 0.34 9.8 4.8 1.1 1 0 0 1 1 1 0 Hsp90 protein Nop14 PF04147.12 KPI87130.1 - 0.28 9.3 9.5 0.33 9.1 9.5 1.1 1 0 0 1 1 1 0 Nop14-like family TLP-20 PF06088.11 KPI87130.1 - 0.3 10.9 2.7 0.43 10.5 2.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF913 PF06025.12 KPI87130.1 - 0.44 9.5 3.1 0.14 11.1 0.8 1.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 KPI87130.1 - 0.47 8.7 6.3 0.57 8.4 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 KPI87130.1 - 0.51 9.5 4.6 0.72 9.0 4.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 KPI87130.1 - 0.89 8.8 8.5 1.2 8.4 8.5 1.1 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 KPI87130.1 - 2.6 7.4 11.1 3.3 7.0 11.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CENP-B_dimeris PF09026.10 KPI87130.1 - 2.9 8.4 17.8 7.3 7.0 17.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pes-10 PF07149.11 KPI87130.1 - 3.6 6.5 8.4 4.4 6.3 8.4 1.1 1 0 0 1 1 1 0 Pes-10 DNA_pol_phi PF04931.13 KPI87130.1 - 6.8 4.7 16.8 9 4.3 16.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi TIP41 PF04176.13 KPI87131.1 - 5.3e-22 78.1 0.0 8.1e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 TIP41-like family GAF_2 PF13185.6 KPI87131.1 - 4.8e-11 43.1 0.2 1.3e-10 41.8 0.1 1.7 2 0 0 2 2 2 1 GAF domain GAF PF01590.26 KPI87131.1 - 1.4e-08 35.4 0.1 3.2e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 KPI87131.1 - 0.00044 20.6 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 GAF domain GCK PF07802.11 KPI87132.1 - 0.0034 17.8 1.2 0.0077 16.6 0.5 2.1 1 1 1 2 2 2 1 GCK domain Cmc1 PF08583.10 KPI87132.1 - 0.011 15.7 1.4 0.021 14.9 1.4 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like NPDC1 PF06809.11 KPI87132.1 - 0.049 12.7 0.4 0.07 12.2 0.4 1.3 1 0 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) TPH PF13868.6 KPI87133.1 - 9e-32 109.9 123.9 9e-32 109.9 123.9 2.0 2 0 0 2 2 2 2 Trichohyalin-plectin-homology domain Ribonuc_red_lgN PF00317.21 KPI87133.1 - 3.5 7.7 11.0 0.27 11.3 2.2 2.8 2 1 0 2 2 2 0 Ribonucleotide reductase, all-alpha domain EXOSC1 PF10447.9 KPI87135.1 - 0.002 18.7 0.0 1.5 9.5 0.0 2.6 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 Peptidase_C13 PF01650.18 KPI87135.1 - 0.14 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase C13 family RTT107_BRCT_5 PF16770.5 KPI87136.1 - 0.037 13.9 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain V-SNARE PF05008.15 KPI87137.1 - 1.5e-13 50.9 2.8 7.7e-13 48.6 0.1 2.8 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 KPI87137.1 - 6.3e-08 32.8 2.4 1.5e-07 31.6 2.4 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KPI87137.1 - 1.1e-06 28.4 2.6 1.1e-06 28.4 2.6 2.1 2 1 0 2 2 2 1 Sec20 Unstab_antitox PF09720.10 KPI87137.1 - 0.00042 20.3 0.1 0.0016 18.5 0.1 2.0 1 0 0 1 1 1 1 Putative addiction module component KASH_CCD PF14662.6 KPI87137.1 - 0.00083 19.2 7.7 0.073 12.9 3.1 2.2 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH LIF_OSM PF01291.17 KPI87137.1 - 0.0065 16.6 0.3 0.097 12.8 0.0 2.1 1 1 1 2 2 2 1 LIF / OSM family Baculo_F PF12259.8 KPI87137.1 - 0.013 14.1 1.2 0.031 12.8 0.2 1.8 2 0 0 2 2 2 0 Baculovirus F protein Spc7 PF08317.11 KPI87137.1 - 0.015 14.2 6.9 0.31 9.9 1.5 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein FUSC PF04632.12 KPI87137.1 - 0.015 13.8 6.1 0.018 13.6 6.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family LRRC37AB_C PF14914.6 KPI87137.1 - 0.063 13.2 2.0 0.11 12.4 2.0 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain PsbN PF02468.15 KPI87137.1 - 0.081 12.8 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) Spore_III_AB PF09548.10 KPI87137.1 - 0.11 12.6 1.0 1.1 9.4 0.1 2.4 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) XhlA PF10779.9 KPI87137.1 - 0.12 12.6 6.2 1.2 9.4 0.3 2.6 2 0 0 2 2 2 0 Haemolysin XhlA TMEM132D_C PF15706.5 KPI87137.1 - 0.13 12.1 0.0 0.38 10.6 0.0 1.8 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term MCU PF04678.13 KPI87137.1 - 0.16 12.1 9.6 0.095 12.8 0.3 2.2 1 1 1 2 2 2 0 Mitochondrial calcium uniporter Nup54 PF13874.6 KPI87137.1 - 0.2 11.8 6.0 0.092 12.9 1.7 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF745 PF05335.13 KPI87137.1 - 0.2 11.4 13.8 0.23 11.2 3.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF745) zf-C4H2 PF10146.9 KPI87137.1 - 0.31 11.3 2.6 8.7 6.6 0.6 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein DUF5082 PF16888.5 KPI87137.1 - 0.38 11.0 10.6 0.24 11.7 0.5 3.1 3 1 1 4 4 3 0 Domain of unknown function (DUF5082) Orf78 PF06024.12 KPI87137.1 - 0.44 10.9 1.9 1.1 9.6 1.9 1.7 1 1 0 1 1 1 0 Orf78 (ac78) HXXSHH PF07586.11 KPI87137.1 - 0.5 9.9 5.2 0.3 10.6 2.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1552) Ribosomal_L30_N PF08079.12 KPI87137.1 - 0.75 10.1 5.0 0.94 9.8 0.7 2.7 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain BRE1 PF08647.11 KPI87137.1 - 0.79 9.8 6.9 6.3 6.9 0.1 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Laminin_I PF06008.14 KPI87137.1 - 0.89 9.2 12.2 17 5.0 12.2 2.1 1 1 0 1 1 1 0 Laminin Domain I DUF883 PF05957.13 KPI87137.1 - 1.4 9.6 13.5 0.57 10.8 1.8 2.8 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF883) RIFIN PF02009.16 KPI87137.1 - 1.4 8.7 7.1 2.6 7.9 7.0 1.5 1 1 0 1 1 1 0 Rifin V-SNARE PF05008.15 KPI87138.1 - 1.6e-08 34.8 5.8 2.4e-08 34.2 0.1 3.1 4 0 0 4 4 4 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 KPI87138.1 - 1.1e-05 25.2 3.8 1.5e-05 24.8 0.2 2.6 2 1 1 3 3 3 1 Sec20 V-SNARE_C PF12352.8 KPI87138.1 - 0.0014 18.9 2.6 0.0014 18.9 2.6 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Laminin_I PF06008.14 KPI87138.1 - 0.015 15.0 2.3 0.015 15.0 2.3 2.3 2 0 0 2 2 2 0 Laminin Domain I DUF883 PF05957.13 KPI87138.1 - 0.031 14.9 5.3 4.9 7.8 2.7 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) T2SSF PF00482.23 KPI87138.1 - 0.036 14.0 0.1 0.036 14.0 0.1 2.2 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F GAT PF03127.14 KPI87138.1 - 0.099 13.0 1.1 1.2 9.5 0.1 2.6 2 0 0 2 2 2 0 GAT domain DASH_Duo1 PF08651.10 KPI87138.1 - 0.34 10.7 8.0 0.51 10.2 1.2 3.4 3 1 0 3 3 3 0 DASH complex subunit Duo1 DivIC PF04977.15 KPI87138.1 - 0.73 9.6 3.4 1.7 8.5 0.1 2.9 3 1 0 3 3 3 0 Septum formation initiator Spc7 PF08317.11 KPI87138.1 - 3.8 6.3 10.6 2.7 6.8 0.4 2.5 3 0 0 3 3 3 0 Spc7 kinetochore protein Synaptobrevin PF00957.21 KPI87138.1 - 7.7 6.4 7.2 2.3 8.1 2.3 2.7 2 2 1 3 3 3 0 Synaptobrevin zf-rbx1 PF12678.7 KPI87140.1 - 3.2e-12 46.5 4.0 5.6e-12 45.8 4.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KPI87140.1 - 1.3e-10 41.4 6.4 4.8e-10 39.6 6.4 1.9 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KPI87140.1 - 1.6e-08 34.2 2.9 2.9e-08 33.5 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI87140.1 - 2.3e-08 33.7 5.0 1.4e-07 31.2 2.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI87140.1 - 1.9e-06 27.7 4.1 2.1e-06 27.6 2.8 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KPI87140.1 - 3.3e-06 27.1 1.0 6.3e-06 26.2 1.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KPI87140.1 - 3.8e-06 26.8 0.0 9.5e-06 25.6 0.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KPI87140.1 - 9.9e-05 22.1 7.5 0.00016 21.5 2.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 KPI87140.1 - 0.00035 20.3 0.2 0.00062 19.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 KPI87140.1 - 0.00055 19.5 1.1 0.00055 19.5 1.1 1.8 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KPI87140.1 - 0.0018 18.1 7.6 0.0022 17.8 2.7 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KPI87140.1 - 0.0078 15.9 0.3 0.0078 15.9 0.3 2.8 3 0 0 3 3 3 1 RING-like zinc finger SbcD_C PF12320.8 KPI87140.1 - 0.068 13.5 0.6 0.15 12.4 0.1 1.8 2 0 0 2 2 1 0 Type 5 capsule protein repressor C-terminal domain FANCL_C PF11793.8 KPI87140.1 - 0.35 11.1 6.4 1.9 8.7 6.4 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 KPI87140.1 - 1.1 9.5 9.8 0.057 13.6 3.9 1.8 2 0 0 2 2 2 0 RING-variant domain zf-RING-like PF08746.11 KPI87140.1 - 1.4 9.3 9.5 0.077 13.3 3.6 1.8 2 0 0 2 2 2 0 RING-like domain zf-C4H2 PF10146.9 KPI87140.1 - 2.1 8.6 5.4 3.3 8.0 5.4 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein DZR PF12773.7 KPI87140.1 - 2.9 8.0 7.0 11 6.2 7.0 1.8 1 1 0 1 1 1 0 Double zinc ribbon Pet100 PF09803.9 KPI87141.1 - 0.22 12.1 8.9 1.2 9.7 8.9 2.0 1 1 0 1 1 1 0 Pet100 B9-C2 PF07162.11 KPI87143.1 - 9.9e-18 64.9 0.0 1.5e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Methyltransf_31 PF13847.6 KPI87144.1 - 0.062 13.1 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PTPlike_phytase PF14566.6 KPI87145.1 - 1.2e-113 376.4 0.0 6e-44 149.9 0.0 3.4 3 0 0 3 3 3 3 Inositol hexakisphosphate DHHC PF01529.20 KPI87146.1 - 9.1e-27 93.8 10.3 9.1e-27 93.8 10.3 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase ETX_MTX2 PF03318.13 KPI87146.1 - 0.043 13.6 0.3 0.065 13.0 0.3 1.1 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 DHHC PF01529.20 KPI87147.1 - 5.6e-29 100.9 4.2 5.6e-29 100.9 4.2 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase GAPT PF11770.8 KPI87147.1 - 0.042 13.7 0.2 0.084 12.7 0.2 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) ACR_tran PF00873.19 KPI87147.1 - 1.8 6.1 2.7 2.5 5.6 2.7 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DHHC PF01529.20 KPI87148.1 - 1e-31 109.8 15.6 1e-31 109.8 15.6 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Fer2_3 PF13085.6 KPI87149.1 - 2.7e-30 104.6 0.1 7e-30 103.3 0.0 1.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 KPI87149.1 - 0.021 14.8 1.0 0.021 14.8 1.0 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain HEAT_2 PF13646.6 KPI87151.1 - 0.057 13.8 13.2 1.1 9.7 0.1 4.8 5 1 1 6 6 6 0 HEAT repeats UMP1 PF05348.11 KPI87151.1 - 0.11 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 Mad3_BUB1_I_2 PF17014.5 KPI87151.1 - 1.8 8.7 3.0 2.3 8.3 0.2 2.3 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein DUF2868 PF11067.8 KPI87156.1 - 0.044 13.3 1.2 0.12 11.9 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) ECH_1 PF00378.20 KPI87163.1 - 1.5e-47 162.0 0.0 2.1e-47 161.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI87163.1 - 1.2e-11 44.7 0.0 1.7e-11 44.2 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 KPI87163.1 - 0.039 13.9 0.1 3.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 Peptidase_M1_N PF17900.1 KPI87164.1 - 1.1e-12 48.5 0.0 1.7e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 KPI87164.1 - 1.5e-07 31.2 0.0 2.3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain DA1-like PF12315.8 KPI87164.1 - 0.079 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein DA1 PBP-Tp47_a PF14889.6 KPI87164.1 - 0.18 11.4 0.1 0.53 9.9 0.0 1.8 2 0 0 2 2 2 0 Penicillin-binding protein Tp47 domain a DUF4704 PF15787.5 KPI87165.1 - 0.039 13.2 0.3 0.27 10.4 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4704) Fes1 PF08609.10 KPI87165.1 - 0.13 13.2 0.0 0.55 11.1 0.0 2.1 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 Arf PF00025.21 KPI87166.1 - 4.7e-75 250.9 0.2 5.4e-75 250.7 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI87166.1 - 2.6e-15 56.7 0.1 3.6e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI87166.1 - 1.2e-14 54.1 0.0 1.5e-14 53.8 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KPI87166.1 - 3.7e-14 52.7 0.0 4.1e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KPI87166.1 - 5.3e-12 45.6 0.4 2.1e-08 33.7 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KPI87166.1 - 5.1e-08 32.6 0.0 6.5e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI87166.1 - 1e-05 25.6 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KPI87166.1 - 0.00099 18.5 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase RsgA_GTPase PF03193.16 KPI87166.1 - 0.025 14.5 0.1 0.98 9.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 KPI87166.1 - 0.11 12.6 0.1 0.14 12.3 0.1 1.3 1 1 0 1 1 1 0 AAA domain PEMT PF04191.13 KPI87167.1 - 1.1e-29 102.9 4.1 1.9e-29 102.2 3.3 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase COX6B PF02297.17 KPI87168.1 - 0.00027 21.1 9.0 0.024 14.8 0.8 2.9 1 1 1 2 2 2 2 Cytochrome oxidase c subunit VIb CX9C PF16860.5 KPI87168.1 - 0.0085 16.1 5.3 3 7.9 2.5 3.3 2 1 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, GCK PF07802.11 KPI87168.1 - 0.038 14.4 1.5 0.038 14.4 1.5 2.8 3 1 0 3 3 3 0 GCK domain COX17 PF05051.13 KPI87168.1 - 0.11 12.9 11.7 0.48 10.8 0.9 3.3 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 KPI87168.1 - 0.35 11.1 7.1 13 6.1 1.9 3.5 2 1 1 3 3 3 0 CHCH domain Cmc1 PF08583.10 KPI87168.1 - 7.7 6.6 14.5 57 3.8 6.3 3.9 2 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Gp_dh_C PF02800.20 KPI87169.1 - 0.018 14.6 0.1 0.03 13.9 0.1 1.3 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain EF-hand_6 PF13405.6 KPI87170.1 - 4e-14 51.3 0.0 0.33 11.0 0.0 6.4 6 0 0 6 6 6 4 EF-hand domain EF-hand_7 PF13499.6 KPI87170.1 - 7.4e-12 45.5 0.0 0.48 10.9 0.0 5.8 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.32 KPI87170.1 - 1.5e-07 30.5 0.0 0.59 9.8 0.0 5.3 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KPI87170.1 - 1.5e-05 24.8 0.0 0.74 9.7 0.0 4.9 5 0 0 5 5 5 2 EF-hand domain pair DUF5580 PF17743.1 KPI87170.1 - 0.011 14.3 0.0 7.9 4.9 0.0 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5580) PrmC_N PF17827.1 KPI87170.1 - 0.17 12.5 2.9 0.57 10.8 0.4 2.9 2 0 0 2 2 2 0 PrmC N-terminal domain DUF3552 PF12072.8 KPI87171.1 - 0.0023 17.4 12.6 0.0035 16.8 12.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) OmpH PF03938.14 KPI87171.1 - 0.4 11.0 23.6 0.7 10.2 23.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Ctr PF04145.15 KPI87171.1 - 0.46 11.1 2.0 1.4 9.5 2.0 1.8 1 0 0 1 1 1 0 Ctr copper transporter family V_ATPase_I PF01496.19 KPI87171.1 - 1.4 6.8 7.7 1.8 6.4 7.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.9 KPI87171.1 - 10 6.4 18.2 18 5.5 18.2 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 KPI87172.1 - 0.38 9.6 9.5 0.7 8.7 9.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein FapA PF03961.13 KPI87172.1 - 2.9 6.4 5.1 4.5 5.8 5.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tho2 PF11262.8 KPI87172.1 - 7.2 5.7 5.9 17 4.5 5.6 1.6 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Abhydrolase_1 PF00561.20 KPI87173.1 - 6.2e-05 22.8 0.0 0.00021 21.0 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI87173.1 - 0.00027 20.3 0.0 0.0017 17.7 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Hydrolase_4 PF12146.8 KPI87174.1 - 0.00026 20.4 0.0 0.00043 19.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI87174.1 - 0.07 12.8 0.0 0.28 10.8 0.0 1.9 2 1 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI87175.1 - 7e-09 35.3 0.0 1.4e-08 34.3 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI87175.1 - 2e-07 30.9 0.0 2.3e-06 27.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold PARP_regulatory PF01358.18 KPI87175.1 - 0.06 12.3 0.0 0.096 11.6 0.0 1.2 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit HEAT PF02985.22 KPI87176.1 - 1.5 9.2 19.1 12 6.5 0.0 8.5 9 1 1 10 10 10 0 HEAT repeat Kinesin PF00225.23 KPI87177.1 - 4.7e-85 285.5 0.0 3.7e-46 157.6 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI87177.1 - 1e-20 74.2 0.0 1.9e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding DUF4600 PF15372.6 KPI87177.1 - 0.0021 18.5 1.4 0.28 11.6 0.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4600) kleA_kleC PF17383.2 KPI87177.1 - 0.41 11.0 12.6 0.31 11.4 0.7 3.5 3 0 0 3 3 3 0 Uncharacterized KorC regulated protein A DUF2703 PF10865.8 KPI87177.1 - 1.4 9.1 5.6 3.3 7.9 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) KELK PF15796.5 KPI87177.1 - 2.2 8.8 7.6 0.3 11.6 0.6 2.6 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Myosin_tail_1 PF01576.19 KPI87177.1 - 4.6 4.9 10.9 13 3.4 0.2 2.4 2 1 0 2 2 2 0 Myosin tail START PF01852.19 KPI87178.1 - 3.9e-21 75.4 0.0 7.9e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 KPI87178.1 - 0.053 13.5 0.1 0.12 12.3 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) DUF5528 PF17666.1 KPI87179.1 - 0.16 11.9 1.4 16 5.4 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5528) LRR_6 PF13516.6 KPI87180.1 - 5.4e-16 57.2 30.6 0.024 14.7 0.4 12.6 14 0 0 14 14 14 5 Leucine Rich repeat LRR_4 PF12799.7 KPI87180.1 - 3.7e-13 49.4 12.2 0.0038 17.6 0.5 9.5 8 1 3 11 11 11 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87180.1 - 3e-09 36.5 25.4 1e-06 28.4 2.3 8.6 10 2 0 10 10 10 3 Leucine rich repeat LRR_1 PF00560.33 KPI87180.1 - 7.9e-08 31.8 11.5 18 6.4 0.1 11.1 11 1 0 11 11 11 1 Leucine Rich Repeat FAM176 PF14851.6 KPI87180.1 - 0.32 10.7 3.9 0.74 9.5 1.0 2.3 2 0 0 2 2 2 0 FAM176 family Ribosomal_L24e PF01246.20 KPI87181.1 - 4.7e-32 110.0 4.1 4.7e-32 110.0 4.1 2.4 2 0 0 2 2 2 1 Ribosomal protein L24e zf-FCS PF06467.14 KPI87181.1 - 0.19 11.7 6.4 0.35 10.8 6.4 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif AAA PF00004.29 KPI87182.1 - 1.3e-39 135.6 0.0 3.9e-39 134.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI87182.1 - 8e-11 41.6 0.2 6.9e-10 38.6 0.0 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 KPI87182.1 - 0.00024 21.5 2.2 0.0046 17.4 0.8 3.5 2 1 0 2 2 1 1 AAA ATPase domain AAA_2 PF07724.14 KPI87182.1 - 0.0038 17.4 0.0 0.031 14.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KPI87182.1 - 0.0045 17.1 0.2 0.029 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI87182.1 - 0.0052 16.8 0.4 0.13 12.3 0.1 2.9 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KPI87182.1 - 0.0071 16.6 0.1 0.13 12.6 0.1 2.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KPI87182.1 - 0.0079 15.9 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 KPI87182.1 - 0.057 13.2 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KPI87182.1 - 0.06 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KPI87182.1 - 0.085 13.4 0.0 0.27 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KPI87182.1 - 0.093 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 KPI87182.1 - 0.11 12.8 0.1 0.11 12.8 0.1 3.2 3 0 0 3 3 3 0 AAA domain Parvo_NS1 PF01057.17 KPI87182.1 - 0.22 10.6 0.0 0.38 9.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PUB PF09409.10 KPI87183.1 - 1e-08 35.0 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 PUB domain SHOCT PF09851.9 KPI87183.1 - 0.0017 18.1 0.2 0.0017 18.1 0.2 2.1 2 0 0 2 2 2 1 Short C-terminal domain DUF702 PF05142.12 KPI87183.1 - 0.12 12.9 4.1 0.27 11.7 4.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF702) DUF3851 PF12962.7 KPI87183.1 - 0.17 12.2 0.5 1 9.7 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3851) PDZ_2 PF13180.6 KPI87185.1 - 0.0053 17.0 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KPI87185.1 - 0.14 12.5 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Tae4 PF14113.6 KPI87186.1 - 0.18 12.1 0.1 0.45 10.8 0.1 1.7 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 SPT6_acidic PF14632.6 KPI87187.1 - 0.0082 16.7 0.1 0.0082 16.7 0.1 3.1 3 0 0 3 3 3 1 Acidic N-terminal SPT6 Alba PF01918.21 KPI87188.1 - 4.7e-16 58.4 0.2 7.2e-16 57.8 0.2 1.4 1 1 0 1 1 1 1 Alba Rpp20 PF12328.8 KPI87188.1 - 0.0006 19.8 2.1 0.00076 19.5 2.1 1.2 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Phage_ABA_S PF18066.1 KPI87188.1 - 0.032 14.9 0.1 0.065 13.9 0.1 1.7 1 1 0 1 1 1 0 Phage ABA sandwich domain Alba PF01918.21 KPI87189.1 - 1.2e-06 28.2 0.2 1.8e-06 27.7 0.2 1.3 1 0 0 1 1 1 1 Alba DUF4140 PF13600.6 KPI87189.1 - 0.045 14.2 0.8 0.064 13.7 0.8 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Pkinase PF00069.25 KPI87190.1 - 1.7e-79 266.9 0.0 2.8e-79 266.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87190.1 - 3.5e-45 154.3 0.0 1.1e-44 152.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Arm PF00514.23 KPI87190.1 - 1.2e-11 44.2 1.1 0.00011 22.1 0.0 5.6 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KPI87190.1 - 1.3e-09 38.4 3.8 0.034 14.7 0.0 5.6 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 KPI87190.1 - 5.9e-07 29.8 0.2 1.1e-05 25.7 0.3 3.1 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 KPI87190.1 - 4.5e-06 26.5 2.1 1.5 9.2 0.0 5.4 4 0 0 4 4 4 1 HEAT repeat Kinase-like PF14531.6 KPI87190.1 - 8.2e-06 25.3 0.0 0.00012 21.5 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI87190.1 - 7.7e-05 21.6 0.0 0.00018 20.4 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 KPI87190.1 - 0.00023 20.8 1.1 0.0036 16.9 0.1 2.2 1 1 0 2 2 2 1 RIO1 family FTA2 PF13095.6 KPI87190.1 - 0.0018 18.0 1.4 0.34 10.5 0.1 2.6 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 KPI87190.1 - 0.0034 16.9 0.3 0.011 15.2 0.1 1.9 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 KPI87190.1 - 0.0044 16.0 0.1 0.0093 14.9 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI87190.1 - 0.0058 16.6 0.0 0.024 14.5 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI87190.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KPI87190.1 - 0.017 14.2 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 WAPL PF07814.13 KPI87190.1 - 0.019 13.8 3.0 0.19 10.5 0.5 3.0 2 1 1 3 3 3 0 Wings apart-like protein regulation of heterochromatin Urb2 PF10441.9 KPI87190.1 - 0.023 14.6 1.9 0.049 13.6 0.0 2.5 3 0 0 3 3 3 0 Urb2/Npa2 family DUF3361 PF11841.8 KPI87190.1 - 0.032 14.2 0.0 6.3 6.7 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) ABC1 PF03109.16 KPI87190.1 - 0.038 14.2 0.1 0.25 11.5 0.0 2.1 1 1 1 2 2 2 0 ABC1 family Orn_DAP_Arg_deC PF00278.22 KPI87190.1 - 0.083 13.1 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Radial_spoke PF04712.12 KPI87191.1 - 1e-115 387.5 15.4 8.1e-86 288.9 6.8 2.6 1 1 1 2 2 2 2 Radial spokehead-like protein AMP-binding PF00501.28 KPI87192.1 - 1e-60 205.5 0.1 1.3e-60 205.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KPI87192.1 - 0.00024 22.0 0.0 0.0013 19.7 0.0 2.3 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain FeoA PF04023.14 KPI87192.1 - 0.14 12.4 0.0 0.45 10.8 0.0 1.9 1 0 0 1 1 1 0 FeoA domain DUF2955 PF11168.8 KPI87193.1 - 0.21 11.4 1.5 0.87 9.4 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2955) Nipped-B_C PF12830.7 KPI87194.1 - 2.2e-24 86.5 0.1 9.6e-24 84.4 0.0 2.1 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus BLOC1S3 PF15753.5 KPI87195.1 - 0.83 9.8 6.8 11 6.1 0.1 3.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Acetyltransf_1 PF00583.25 KPI87196.1 - 4e-14 52.9 0.1 8.2e-14 51.8 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KPI87196.1 - 1.2e-07 31.6 0.0 1.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 KPI87196.1 - 1.6e-07 31.3 0.4 3e-07 30.4 0.4 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI87196.1 - 1.1e-05 25.8 0.1 2.3e-05 24.7 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KPI87196.1 - 0.038 14.1 0.2 0.057 13.6 0.2 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KPI87196.1 - 0.056 12.9 0.4 0.072 12.6 0.4 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_9 PF13527.7 KPI87196.1 - 0.066 13.3 1.5 0.067 13.3 0.1 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain WD40 PF00400.32 KPI87197.1 - 0.083 13.8 2.2 2.8 9.0 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF4200 PF13863.6 KPI87198.1 - 3.8e-23 82.2 26.0 3.8e-23 82.2 26.0 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF4200) DUF3918 PF13056.6 KPI87198.1 - 0.093 12.4 0.2 0.22 11.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) Ribonuc_red_2_N PF08471.10 KPI87198.1 - 0.15 12.3 4.0 0.33 11.2 3.5 1.9 1 1 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase AATF-Che1 PF13339.6 KPI87198.1 - 0.23 12.1 21.8 0.23 12.2 6.8 3.1 2 1 1 3 3 3 0 Apoptosis antagonizing transcription factor KIF1B PF12423.8 KPI87198.1 - 1.2 9.7 4.2 1.7 9.2 1.5 2.6 2 0 0 2 2 2 0 Kinesin protein 1B TACC_C PF05010.14 KPI87198.1 - 1.8 8.3 34.6 0.85 9.4 31.7 1.8 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal V_ATPase_I PF01496.19 KPI87198.1 - 4.5 5.1 23.9 6.1 4.6 23.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATG16 PF08614.11 KPI87198.1 - 5.8 7.1 36.3 4.3 7.5 10.9 2.8 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) zf-RING_5 PF14634.6 KPI87199.1 - 3.7e-06 26.8 8.8 6.4e-06 26.0 8.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KPI87199.1 - 0.00064 19.5 13.2 0.0011 18.7 13.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI87199.1 - 0.00075 19.8 11.3 0.0013 19.0 11.3 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KPI87199.1 - 0.0043 16.9 12.7 0.0043 16.9 12.7 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 CENP-Q PF13094.6 KPI87199.1 - 0.011 15.9 0.1 0.016 15.4 0.1 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit zf-C3HC4 PF00097.25 KPI87199.1 - 0.024 14.5 8.7 0.042 13.7 8.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI87199.1 - 0.11 12.3 10.2 0.22 11.4 10.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Jnk-SapK_ap_N PF09744.9 KPI87199.1 - 0.19 11.9 2.9 0.29 11.4 2.9 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 SlyX PF04102.12 KPI87199.1 - 0.59 10.8 7.1 5.2 7.8 0.1 2.5 1 1 1 2 2 2 0 SlyX FliT PF05400.13 KPI87199.1 - 2.1 9.2 9.3 0.77 10.6 0.6 2.5 1 1 1 2 2 2 0 Flagellar protein FliT zf-RING_4 PF14570.6 KPI87199.1 - 4.3 7.2 11.1 8.3 6.3 11.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 KPI87199.1 - 8.9 6.4 10.6 21 5.3 10.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Ras PF00071.22 KPI87200.1 - 1.8e-51 174.0 0.3 2.1e-51 173.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI87200.1 - 3.9e-33 114.2 0.0 5.6e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI87200.1 - 4.2e-14 52.4 0.0 5.4e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI87200.1 - 1.3e-07 31.2 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KPI87200.1 - 1.4e-06 28.3 0.8 0.0015 18.4 0.2 2.1 1 1 1 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KPI87200.1 - 2.8e-05 24.6 0.0 4.2e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KPI87200.1 - 7.6e-05 22.8 0.0 0.00011 22.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KPI87200.1 - 0.00093 19.5 0.0 0.0044 17.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KPI87200.1 - 0.0021 17.6 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region SRPRB PF09439.10 KPI87200.1 - 0.0041 16.6 0.0 0.0078 15.7 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit TsaE PF02367.17 KPI87200.1 - 0.0074 16.3 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KPI87200.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 KPI87200.1 - 0.013 15.3 0.0 0.028 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KPI87200.1 - 0.014 15.4 0.1 0.026 14.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) VirE PF05272.11 KPI87200.1 - 0.031 14.0 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E G-alpha PF00503.20 KPI87200.1 - 0.032 13.4 0.7 0.39 9.8 0.1 2.1 1 1 1 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.6 KPI87200.1 - 0.034 14.7 0.1 0.045 14.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KPI87200.1 - 0.047 14.2 0.1 0.1 13.1 0.1 1.5 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 KPI87200.1 - 0.049 13.5 0.0 0.08 12.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 KPI87200.1 - 0.061 13.7 0.0 0.095 13.1 0.0 1.5 1 1 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 KPI87200.1 - 0.076 12.8 0.1 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 KPI87200.1 - 0.082 13.1 0.0 0.17 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 KPI87200.1 - 0.084 13.3 0.0 0.2 12.1 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 KPI87200.1 - 0.094 11.9 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 KPI87200.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DAP3 PF10236.9 KPI87200.1 - 0.15 11.2 0.4 0.25 10.5 0.1 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Lipase_3 PF01764.25 KPI87201.1 - 1.8e-16 60.3 0.0 4.1e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) FYVE PF01363.21 KPI87201.1 - 0.0025 17.9 19.1 0.0025 17.9 19.1 3.5 2 1 1 3 3 3 1 FYVE zinc finger Thioesterase PF00975.20 KPI87201.1 - 0.025 14.7 0.1 0.049 13.7 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain UPF0227 PF05728.12 KPI87201.1 - 0.026 14.5 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 KPI87201.1 - 0.071 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 SLATT_fungal PF18142.1 KPI87201.1 - 0.15 12.1 0.4 0.36 10.8 0.4 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Abhydrolase_6 PF12697.7 KPI87201.1 - 1 9.9 10.8 3.4 8.2 10.6 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family zf-FPG_IleRS PF06827.14 KPI87201.1 - 3.5 7.6 18.2 3.7 7.5 2.9 4.7 3 1 1 4 4 4 0 Zinc finger found in FPG and IleRS Lipase_3 PF01764.25 KPI87202.1 - 2e-14 53.7 0.0 3.4e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) FYVE_2 PF02318.16 KPI87202.1 - 1.2 9.4 16.2 3.7 7.8 16.2 1.9 1 0 0 1 1 1 0 FYVE-type zinc finger FYVE PF01363.21 KPI87202.1 - 2.5 8.3 30.4 1.2 9.4 26.8 2.2 2 0 0 2 2 2 0 FYVE zinc finger TPR_12 PF13424.6 KPI87204.1 - 1.8e-12 47.4 20.4 1.3e-07 31.8 1.8 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 KPI87204.1 - 1.2e-07 31.3 11.4 0.0029 17.4 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87204.1 - 0.031 14.1 4.7 0.044 13.6 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87204.1 - 0.074 13.2 16.0 0.11 12.7 0.2 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 KPI87204.1 - 0.095 13.4 22.7 0.28 11.9 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87204.1 - 0.24 12.0 9.5 2.2 8.8 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KPI87204.1 - 0.61 10.6 3.6 5.1 7.7 0.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat MOZ_SAS PF01853.18 KPI87205.1 - 1.1e-23 83.8 0.0 3.2e-23 82.3 0.0 1.8 1 1 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KPI87205.1 - 0.012 15.2 2.3 0.028 14.0 2.3 1.6 1 0 0 1 1 1 0 MYST family zinc finger domain cNMP_binding PF00027.29 KPI87206.1 - 6.8e-30 103.0 0.1 2.3e-16 59.7 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Kinesin PF00225.23 KPI87209.1 - 1.2e-87 293.9 0.0 1.7e-87 293.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI87209.1 - 1.7e-14 54.0 0.0 3.2e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding zf-TRAF PF02176.18 KPI87209.1 - 5.3e-09 36.6 46.1 0.00053 20.6 7.9 5.2 4 1 2 6 6 6 4 TRAF-type zinc finger zf-Di19 PF05605.12 KPI87209.1 - 0.072 13.4 26.5 1.5 9.1 4.4 4.8 3 2 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding TRAF6_Z2 PF18048.1 KPI87209.1 - 0.16 12.1 7.3 5.1 7.3 3.9 3.1 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 PhoH PF02562.16 KPI87209.1 - 0.18 11.2 0.4 1.3 8.4 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein UBZ_FAAP20 PF15750.5 KPI87209.1 - 2.8 8.0 10.9 8.7 6.4 1.4 3.2 2 1 0 2 2 2 0 Ubiquitin-binding zinc-finger zf_UBZ PF18439.1 KPI87209.1 - 2.8 7.6 15.5 6.4 6.5 0.5 4.6 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger PHD_4 PF16866.5 KPI87209.1 - 9 6.5 25.0 3.2 7.9 7.5 3.5 1 1 0 2 2 2 0 PHD-finger HALZ PF02183.18 KPI87211.1 - 0.013 15.7 3.5 0.1 12.8 1.3 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Atg14 PF10186.9 KPI87211.1 - 0.027 13.6 1.0 0.033 13.3 1.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 F_actin_bind PF08919.10 KPI87211.1 - 0.097 12.8 0.1 0.097 12.8 0.1 1.7 2 0 0 2 2 2 0 F-actin binding Sas6_CC PF18594.1 KPI87211.1 - 0.16 11.7 0.6 0.31 10.9 0.6 1.4 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain Spc24 PF08286.11 KPI87211.1 - 0.2 11.9 1.5 0.29 11.4 1.5 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 TMPIT PF07851.13 KPI87211.1 - 0.27 10.4 1.9 0.32 10.2 1.9 1.0 1 0 0 1 1 1 0 TMPIT-like protein ZapB PF06005.12 KPI87211.1 - 0.29 11.6 8.8 0.31 11.5 6.9 1.8 2 0 0 2 2 2 0 Cell division protein ZapB PRKG1_interact PF15898.5 KPI87211.1 - 0.47 11.4 6.1 0.29 12.1 2.5 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain SURF1 PF02104.15 KPI87212.1 - 2.7e-29 102.7 0.9 2.7e-29 102.6 0.0 1.4 2 0 0 2 2 2 1 SURF1 family RRM_1 PF00076.22 KPI87217.1 - 8.2e-08 32.0 0.0 1.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Btz PF09405.10 KPI87217.1 - 0.025 14.9 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding Fer2 PF00111.27 KPI87218.1 - 6.1e-11 42.1 1.0 9.4e-11 41.5 1.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Peptidase_M28 PF04389.17 KPI87219.1 - 0.0017 18.1 0.2 0.0038 16.9 0.2 1.7 1 0 0 1 1 1 1 Peptidase family M28 ArnB_C PF18677.1 KPI87219.1 - 0.16 12.1 0.4 0.59 10.3 0.0 2.1 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain Aldo_ket_red PF00248.21 KPI87220.1 - 0.0069 15.6 0.0 0.034 13.3 0.0 2.0 2 0 0 2 2 2 1 Aldo/keto reductase family AAA_6 PF12774.7 KPI87221.1 - 2.4e-154 513.2 0.0 2.1e-153 510.1 0.0 2.3 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI87221.1 - 1.3e-113 380.1 9.7 1.3e-113 380.1 9.7 3.3 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI87221.1 - 2.8e-100 334.9 0.0 7.8e-100 333.5 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KPI87221.1 - 2.9e-94 315.8 0.0 3.9e-93 312.0 0.0 2.7 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KPI87221.1 - 2.3e-86 288.5 0.4 2.3e-86 288.5 0.4 2.3 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI87221.1 - 2.1e-54 183.8 0.1 2.6e-50 170.5 0.0 3.9 4 0 0 4 4 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI87221.1 - 7.9e-52 175.4 0.0 2.4e-51 173.8 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KPI87221.1 - 1.9e-49 168.6 8.5 3.5e-49 167.7 8.5 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KPI87221.1 - 2.4e-39 134.1 0.1 2.5e-36 124.4 0.0 4.3 4 0 0 4 4 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KPI87221.1 - 1.9e-22 79.7 0.0 7.6e-06 26.0 0.0 5.8 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KPI87221.1 - 2e-19 69.9 0.1 4.5e-18 65.6 0.1 3.2 2 1 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KPI87221.1 - 2.6e-15 56.4 0.0 9.8e-15 54.6 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KPI87221.1 - 6.9e-07 29.8 10.4 2.3 8.6 0.0 7.6 6 1 0 7 7 6 1 AAA ATPase domain AAA PF00004.29 KPI87221.1 - 1.6e-06 28.6 0.2 1.6 9.2 0.0 4.8 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI87221.1 - 1.8e-05 25.1 0.7 9.6 6.5 0.0 5.7 5 0 0 5 5 5 0 AAA domain FtsK_SpoIIIE PF01580.18 KPI87221.1 - 0.024 14.0 0.6 2.6 7.3 0.0 3.3 3 0 0 3 3 3 0 FtsK/SpoIIIE family T2SSE PF00437.20 KPI87221.1 - 0.025 13.7 0.0 8.2 5.4 0.0 2.8 3 0 0 3 3 3 0 Type II/IV secretion system protein DUF815 PF05673.13 KPI87221.1 - 0.033 13.4 0.7 24 4.0 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 KPI87221.1 - 0.095 12.4 4.6 2.5 7.8 0.2 4.2 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.22 KPI87221.1 - 0.2 12.1 0.4 5.5 7.4 0.0 3.4 3 0 0 3 3 2 0 RNA helicase AAA_29 PF13555.6 KPI87221.1 - 0.22 11.3 0.6 1.9 8.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain KxDL PF10241.9 KPI87221.1 - 0.39 11.0 3.9 1.2 9.5 0.2 3.7 3 0 0 3 3 2 0 Uncharacterized conserved protein SH3BP5 PF05276.14 KPI87221.1 - 3.9 7.2 10.9 8.8 6.0 4.7 2.8 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) DegS PF05384.11 KPI87221.1 - 4.1 6.9 8.9 4.3 6.8 3.7 2.9 2 0 0 2 2 2 0 Sensor protein DegS PI3K_P85_iSH2 PF16454.5 KPI87221.1 - 6 6.5 7.3 2.2 7.9 2.0 2.9 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PRKCSH-like PF12999.7 KPI87223.1 - 6.6e-39 133.5 1.7 3.4e-38 131.2 0.2 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 KPI87223.1 - 5.3e-21 74.9 0.1 1.1e-20 73.9 0.1 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 KPI87223.1 - 0.0029 18.6 0.6 0.0059 17.6 0.6 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.18 KPI87223.1 - 0.0082 16.3 17.5 0.042 14.1 3.5 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Val_tRNA-synt_C PF10458.9 KPI87223.1 - 0.2 12.0 9.7 0.49 10.7 0.4 3.3 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm eIF3_N PF09440.10 KPI87223.1 - 0.4 11.1 9.1 43 4.5 8.8 2.3 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain Atg14 PF10186.9 KPI87223.1 - 0.44 9.6 4.9 0.59 9.2 4.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF148 PF02520.17 KPI87223.1 - 1.7 8.8 4.9 1.3 9.2 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF148 OmpH PF03938.14 KPI87223.1 - 7.5 6.9 13.7 0.079 13.3 2.6 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) PKD_channel PF08016.12 KPI87224.1 - 4.2e-08 32.3 8.4 7.1e-08 31.5 8.4 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KPI87224.1 - 6.2e-07 28.9 9.0 6.2e-07 28.9 9.0 1.7 2 0 0 2 2 2 1 Ion transport protein Pkinase PF00069.25 KPI87225.1 - 2.3e-28 99.3 0.0 7.5e-28 97.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87225.1 - 1.6e-09 37.5 0.0 0.00048 19.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase NMD3 PF04981.13 KPI87226.1 - 2.4e-76 256.4 4.7 2.4e-76 256.4 4.7 1.4 2 0 0 2 2 2 1 NMD3 family Mcp5_PH PF12814.7 KPI87228.1 - 1.6e-22 79.9 0.7 3.3e-22 78.9 0.7 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF3395 PF11875.8 KPI87229.1 - 1.3e-38 132.4 0.0 4.1e-38 130.8 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 KPI87229.1 - 1.5e-16 60.2 0.1 2.7e-16 59.4 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain PIF1 PF05970.14 KPI87230.1 - 2e-06 27.2 0.0 3.4e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase IstB_IS21 PF01695.17 KPI87230.1 - 0.014 15.1 0.1 0.13 12.0 0.1 2.5 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 KPI87230.1 - 0.039 13.7 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain OrsD PF12013.8 KPI87230.1 - 0.041 14.3 0.3 0.041 14.3 0.3 2.6 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D SRP54 PF00448.22 KPI87230.1 - 0.14 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MCM PF00493.23 KPI87230.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain OGFr_N PF04664.13 KPI87232.1 - 6.2e-07 29.2 0.5 6.1e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Opioid growth factor receptor (OGFr) conserved region HSP70 PF00012.20 KPI87233.1 - 8e-78 262.1 0.0 4.5e-42 144.0 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KPI87233.1 - 0.00085 18.2 0.0 0.35 9.6 0.0 3.2 3 0 0 3 3 3 2 MreB/Mbl protein CSD PF00313.22 KPI87234.1 - 5.3e-06 26.2 0.0 0.0021 17.8 0.0 2.4 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain Rit1_C PF17184.4 KPI87234.1 - 0.16 11.4 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 Rit1 N-terminal domain CSD PF00313.22 KPI87236.1 - 1.1e-08 34.8 0.1 2.6e-05 24.0 0.0 2.4 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain CSD PF00313.22 KPI87237.1 - 0.0031 17.3 0.0 4.3 7.3 0.0 2.9 3 1 0 3 3 3 2 'Cold-shock' DNA-binding domain AP_endonuc_2 PF01261.24 KPI87238.1 - 0.059 12.8 3.8 0.67 9.3 0.1 2.8 1 1 2 3 3 3 0 Xylose isomerase-like TIM barrel YabA PF06156.13 KPI87238.1 - 0.59 10.8 15.1 2.2 8.9 0.6 3.3 3 0 0 3 3 3 0 Initiation control protein YabA Toprim_2 PF13155.6 KPI87238.1 - 1.8 9.0 4.1 0.7 10.4 0.1 2.4 3 1 0 3 3 3 0 Toprim-like ATG16 PF08614.11 KPI87238.1 - 5.3 7.2 41.3 3.9 7.7 7.3 3.2 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 KPI87238.1 - 6.6 6.8 18.5 2 8.4 0.7 4.0 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) SBD_N PF07005.11 KPI87238.1 - 6.7 6.4 10.6 0.25 11.0 0.7 2.8 2 1 1 3 3 3 0 Sugar-binding N-terminal domain SPRY PF00622.28 KPI87239.1 - 3.1e-06 27.3 0.0 9.2e-06 25.8 0.0 1.8 1 1 0 1 1 1 1 SPRY domain DUF4201 PF13870.6 KPI87239.1 - 0.0015 18.3 6.6 0.0015 18.3 6.6 8.0 4 3 4 8 8 8 1 Domain of unknown function (DUF4201) UPF0242 PF06785.11 KPI87239.1 - 0.0028 17.8 9.5 0.0028 17.8 9.5 5.5 3 2 2 5 5 5 2 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 KPI87239.1 - 0.0064 15.4 92.2 0.046 12.6 20.7 5.2 4 1 1 5 5 5 3 Spc7 kinetochore protein zf-LSD1 PF06943.12 KPI87243.1 - 1.4e-10 40.8 6.7 1.4e-10 40.8 6.7 2.4 2 0 0 2 2 2 1 LSD1 zinc finger zinc-ribbons_6 PF07191.12 KPI87243.1 - 0.18 11.8 12.6 1.5 8.8 9.3 2.2 2 0 0 2 2 2 0 zinc-ribbons DZR PF12773.7 KPI87243.1 - 0.25 11.4 17.2 3.7 7.6 11.1 2.4 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 KPI87243.1 - 1.5 8.8 0.0 1.5 8.8 0.0 4.0 3 1 1 4 4 4 0 zinc-ribbon domain ABC_membrane PF00664.23 KPI87246.1 - 1.5e-44 152.7 21.8 1e-22 81.1 8.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KPI87246.1 - 1.3e-33 116.5 0.0 9.7e-16 58.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 KPI87246.1 - 2.3e-06 27.3 0.2 0.093 12.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 KPI87246.1 - 1.2e-05 24.8 0.3 0.015 14.7 0.1 2.6 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_16 PF13191.6 KPI87246.1 - 4.2e-05 24.0 2.1 0.057 13.8 0.7 3.2 2 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 KPI87246.1 - 5.1e-05 22.8 0.0 0.0041 16.6 0.0 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KPI87246.1 - 5.4e-05 23.1 0.0 1.1 9.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 KPI87246.1 - 0.00053 20.2 2.5 0.49 10.5 0.1 2.3 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_25 PF13481.6 KPI87246.1 - 0.00066 19.3 0.9 0.079 12.5 0.1 2.6 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KPI87246.1 - 0.00077 18.6 0.1 0.91 8.5 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein MMR_HSR1 PF01926.23 KPI87246.1 - 0.0015 18.6 0.2 0.45 10.6 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KPI87246.1 - 0.0015 18.8 2.1 0.6 10.4 0.2 2.7 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KPI87246.1 - 0.0018 18.2 0.1 0.59 10.0 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_23 PF13476.6 KPI87246.1 - 0.0027 18.2 0.0 3.4 8.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain TNFR_16_TM PF18422.1 KPI87246.1 - 0.003 17.5 0.8 0.0092 15.9 0.8 1.8 1 0 0 1 1 1 1 Tumor necrosis factor receptor member 16 trans-membrane domain MeaB PF03308.16 KPI87246.1 - 0.0064 15.5 0.6 1.9 7.4 0.1 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 KPI87246.1 - 0.0066 16.4 0.9 1.1 9.2 0.1 2.6 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 KPI87246.1 - 0.021 14.4 0.2 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 KPI87246.1 - 0.024 14.3 0.2 4.9 6.8 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain CAP_GLY PF01302.25 KPI87246.1 - 0.028 14.4 0.1 0.12 12.4 0.1 2.1 1 0 0 1 1 1 0 CAP-Gly domain AAA_30 PF13604.6 KPI87246.1 - 0.032 14.0 0.4 6 6.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KPI87246.1 - 0.072 12.4 0.2 3.5 6.9 0.0 2.5 3 0 0 3 3 3 0 KaiC TrwB_AAD_bind PF10412.9 KPI87246.1 - 0.094 11.6 1.5 4 6.2 0.3 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 KPI87246.1 - 0.27 11.3 0.6 19 5.3 0.2 2.3 2 0 0 2 2 2 0 Dynamin family AAA_33 PF13671.6 KPI87246.1 - 0.4 10.8 4.6 1.9 8.6 0.7 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KPI87246.1 - 0.5 9.9 4.3 12 5.4 0.4 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 KPI87246.1 - 0.91 9.6 2.6 8.7 6.4 0.5 2.9 3 0 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain zinc_ribbon_16 PF17034.5 KPI87247.1 - 0.00016 21.9 14.6 0.00016 21.9 14.6 2.4 1 1 1 2 2 2 1 Zinc-ribbon like family BSD PF03909.17 KPI87248.1 - 0.0076 16.2 2.5 0.028 14.4 0.3 2.7 3 0 0 3 3 3 1 BSD domain Cullin PF00888.22 KPI87249.1 - 1.1e-47 163.0 0.0 6.9e-47 160.4 0.0 1.9 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KPI87249.1 - 1.2e-12 47.7 0.0 2.5e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Cullin protein neddylation domain NPL4 PF05021.15 KPI87250.1 - 1.6e-18 67.2 0.2 8.8e-10 38.4 0.0 3.1 2 1 0 2 2 2 2 NPL4 family Ribosomal_L32p PF01783.23 KPI87250.1 - 0.011 16.0 0.9 0.024 14.9 0.9 1.5 1 0 0 1 1 1 0 Ribosomal L32p protein family PRP38 PF03371.15 KPI87251.1 - 2.6e-05 24.2 0.1 4.5e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 PRP38 family MbeB_N PF04837.12 KPI87251.1 - 0.12 12.7 0.1 1.2 9.5 0.0 2.6 3 0 0 3 3 3 0 MbeB-like, N-term conserved region PPP4R2 PF09184.11 KPI87252.1 - 3.4e-06 26.9 0.0 6.2e-06 26.0 0.0 1.4 2 0 0 2 2 2 1 PPP4R2 RNA_pol_N PF01194.17 KPI87253.1 - 2.4e-29 101.4 1.0 2.9e-29 101.1 1.0 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 KPI87253.1 - 0.087 13.1 0.3 0.12 12.6 0.3 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Metallophos PF00149.28 KPI87254.1 - 1.6e-34 120.2 0.9 2.3e-34 119.7 0.9 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GIY-YIG PF01541.24 KPI87258.1 - 8.2e-11 42.0 0.0 1.5e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain Sec23_trunk PF04811.15 KPI87259.1 - 2.1e-37 129.0 0.0 3.2e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KPI87259.1 - 2.7e-21 75.3 0.0 4.7e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KPI87259.1 - 2e-18 66.9 0.5 3.7e-18 66.0 0.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KPI87259.1 - 6.9e-11 42.0 1.5 1.7e-10 40.8 1.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger ASH PF15780.5 KPI87260.1 - 3e-10 40.2 3.4 3.2e-06 27.2 0.0 5.5 6 0 0 6 6 6 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 KPI87260.1 - 0.0013 18.9 0.2 0.24 11.6 0.0 4.0 5 0 0 5 5 5 1 Transmembrane protein 131-like PapD-like PF14874.6 KPI87260.1 - 0.022 14.9 2.2 2 8.6 0.1 4.2 4 0 0 4 4 4 0 Flagellar-associated PapD-like TAP42 PF04177.12 KPI87262.1 - 9e-46 156.5 6.1 5.2e-45 154.0 6.1 1.9 1 1 0 1 1 1 1 TAP42-like family ATP_bind_1 PF03029.17 KPI87264.1 - 3.4e-60 203.8 0.0 3.9e-60 203.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 KPI87264.1 - 8.5e-05 23.1 0.0 0.00016 22.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI87264.1 - 0.00038 20.2 0.0 0.00051 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 KPI87264.1 - 0.002 17.8 0.0 0.0041 16.8 0.0 1.5 2 0 0 2 2 1 1 SRP54-type protein, GTPase domain GTP_EFTU PF00009.27 KPI87264.1 - 0.0023 17.5 0.0 0.1 12.1 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 KPI87264.1 - 0.0029 18.1 0.0 0.0066 17.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 KPI87264.1 - 0.0037 17.5 0.0 0.0072 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI87264.1 - 0.0044 17.4 0.0 0.0098 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain CLP1_P PF16575.5 KPI87264.1 - 0.0047 16.7 0.0 0.012 15.4 0.0 1.6 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop PduV-EutP PF10662.9 KPI87264.1 - 0.006 16.3 0.0 0.36 10.6 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 KPI87264.1 - 0.014 15.5 0.0 0.075 13.1 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 KPI87264.1 - 0.016 15.4 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KPI87264.1 - 0.017 15.6 0.1 0.055 13.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KPI87264.1 - 0.023 15.1 0.0 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Cytidylate_kin PF02224.18 KPI87264.1 - 0.027 14.2 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase RsgA_GTPase PF03193.16 KPI87264.1 - 0.033 14.1 0.0 0.4 10.6 0.0 2.4 3 0 0 3 3 3 0 RsgA GTPase AAA_29 PF13555.6 KPI87264.1 - 0.037 13.8 0.1 0.078 12.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 KPI87264.1 - 0.064 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 KPI87264.1 - 0.069 13.3 0.0 0.17 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KPI87264.1 - 0.097 12.7 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KPI87264.1 - 0.1 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KPI87264.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 KPI87264.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein KAP_NTPase PF07693.14 KPI87264.1 - 0.15 11.2 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain G-alpha PF00503.20 KPI87264.1 - 0.21 10.7 0.0 7.6 5.6 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit ADK PF00406.22 KPI87264.1 - 0.22 11.6 0.1 0.39 10.8 0.1 1.4 1 0 0 1 1 1 0 Adenylate kinase Surp PF01805.20 KPI87265.1 - 1.8e-12 47.0 0.8 7.7e-09 35.4 0.1 2.4 2 0 0 2 2 2 2 Surp module FAP PF07174.11 KPI87265.1 - 0.2 11.1 15.4 0.34 10.3 15.4 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DNA_pol_D_N PF18018.1 KPI87266.1 - 1.5e-28 99.5 0.0 3e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 KPI87266.1 - 2.3e-25 89.2 0.4 2e-13 50.2 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase alpha/epsilon subunit B Ras PF00071.22 KPI87267.1 - 2.9e-50 170.0 0.0 3.5e-50 169.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI87267.1 - 1.1e-31 109.5 0.0 1.8e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI87267.1 - 8.6e-11 41.6 0.0 1.2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 KPI87267.1 - 0.00033 21.0 0.3 0.0024 18.3 0.3 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 KPI87267.1 - 0.00074 18.9 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI87267.1 - 0.0012 19.0 0.0 0.0019 18.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI87267.1 - 0.011 15.6 0.1 2.9 7.8 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase G-alpha PF00503.20 KPI87267.1 - 0.012 14.8 1.0 0.95 8.5 0.1 2.7 2 1 1 3 3 3 0 G-protein alpha subunit GTP_EFTU PF00009.27 KPI87267.1 - 0.015 14.8 0.3 0.066 12.8 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 KPI87267.1 - 0.036 13.6 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 KPI87267.1 - 0.038 14.1 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 KPI87267.1 - 0.041 13.3 0.1 0.075 12.5 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein cobW PF02492.19 KPI87267.1 - 0.088 12.4 0.1 4 7.0 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 KPI87267.1 - 0.092 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 KPI87267.1 - 0.096 12.7 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.18 KPI87267.1 - 0.11 11.8 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 KPI87267.1 - 0.14 11.9 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain Cluap1 PF10234.9 KPI87268.1 - 1.1e-87 293.8 17.1 1.5e-87 293.4 17.1 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 ParD_antitoxin PF03693.14 KPI87268.1 - 0.52 10.8 4.1 2.9 8.4 1.4 3.0 2 1 0 3 3 3 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Lectin_N PF03954.14 KPI87268.1 - 1.3 8.8 9.2 0.15 11.8 2.0 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DHHA1 PF02272.19 KPI87268.1 - 2.8 8.4 7.8 11 6.5 3.2 2.6 2 1 0 2 2 2 0 DHHA1 domain RNase_T PF00929.24 KPI87269.1 - 1.1e-06 29.3 0.0 2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DUF1295 PF06966.12 KPI87272.1 - 1.5e-09 37.8 1.1 2e-09 37.3 0.5 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 KPI87272.1 - 0.00093 19.6 0.6 0.00093 19.6 0.6 2.6 3 1 0 3 3 3 1 Phospholipid methyltransferase Steroid_dh PF02544.16 KPI87272.1 - 0.018 15.0 0.7 0.018 15.0 0.7 2.1 1 1 2 3 3 3 0 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 KPI87272.1 - 0.075 13.5 0.1 0.18 12.3 0.1 1.7 1 1 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PCRF PF03462.18 KPI87273.1 - 5e-29 101.5 0.7 5e-29 101.5 0.7 1.8 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 KPI87273.1 - 3.9e-26 91.3 0.3 9.9e-26 90.0 0.3 1.7 1 0 0 1 1 1 1 RF-1 domain MDMPI_N PF11716.8 KPI87273.1 - 0.1 13.3 0.3 0.33 11.6 0.1 1.9 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF1126 PF06565.12 KPI87274.1 - 1.1e-68 227.7 0.8 1.3e-22 79.6 0.0 3.5 3 0 0 3 3 3 3 DUF1126 PH-like domain EF-hand_7 PF13499.6 KPI87274.1 - 0.032 14.7 0.2 3.8 8.1 0.0 3.1 2 0 0 2 2 2 0 EF-hand domain pair Cyclin_N PF00134.23 KPI87275.1 - 2e-38 131.0 0.5 2e-38 131.0 0.5 2.1 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KPI87275.1 - 4.8e-17 62.2 1.5 9.3e-17 61.2 1.5 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain NfI_DNAbd_pre-N PF10524.9 KPI87275.1 - 0.027 14.3 0.1 0.068 13.0 0.0 1.7 2 0 0 2 2 2 0 Nuclear factor I protein pre-N-terminus His_Phos_1 PF00300.22 KPI87276.1 - 5.8e-17 62.0 0.6 6.5e-06 26.0 0.1 3.1 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.22 KPI87277.1 - 6.7e-18 65.1 3.6 6e-06 26.1 0.1 3.4 1 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) DUF4175 PF13779.6 KPI87277.1 - 0.061 11.2 1.9 0.085 10.8 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4398 PF14346.6 KPI87277.1 - 1.4 9.6 8.4 0.18 12.4 3.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) RCC1 PF00415.18 KPI87278.1 - 5.8e-34 116.5 14.5 4.3e-10 40.1 0.0 7.4 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI87278.1 - 2e-16 59.3 22.6 1.8e-06 27.6 3.1 6.9 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat TatD_DNase PF01026.21 KPI87280.1 - 2.1e-27 96.1 0.0 6.8e-26 91.2 0.0 2.1 2 0 0 2 2 2 1 TatD related DNase GDE_N_bis PF14742.6 KPI87280.1 - 0.085 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of (some) glycogen debranching enzymes Tox-MPTase2 PF15638.6 KPI87280.1 - 0.15 11.7 0.1 0.37 10.5 0.0 1.6 2 0 0 2 2 2 0 Metallopeptidase toxin 2 TPR_12 PF13424.6 KPI87281.1 - 0.00071 19.8 5.6 1.8 8.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87281.1 - 0.00078 19.4 11.1 0.58 10.4 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87281.1 - 0.00078 19.3 3.3 1 9.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87281.1 - 0.0014 18.3 2.7 0.94 9.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KPI87281.1 - 0.022 14.2 0.9 0.064 12.7 0.9 1.8 1 0 0 1 1 1 0 SHNi-TPR TPR_8 PF13181.6 KPI87281.1 - 0.025 14.8 0.7 7.8 7.0 0.2 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87281.1 - 0.076 13.5 6.2 0.15 12.6 2.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI87281.1 - 0.23 12.2 9.3 14 6.5 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KPI87281.1 - 1.2 9.9 0.0 1.2 9.9 0.0 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Peptidase_M14 PF00246.24 KPI87282.1 - 2.5e-15 57.0 0.2 1.5e-14 54.5 0.2 2.2 1 1 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 KPI87282.1 - 4.9e-08 33.3 0.0 9.5e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AstE_AspA PF04952.14 KPI87282.1 - 2e-06 27.1 0.0 3.1e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family V-SNARE_C PF12352.8 KPI87283.1 - 4e-08 33.4 3.2 9.7e-08 32.2 2.3 2.0 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus SSFA2_C PF14723.6 KPI87283.1 - 0.014 15.3 0.1 0.014 15.3 0.1 1.6 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus BAR_3 PF16746.5 KPI87283.1 - 0.024 14.3 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 BAR domain of APPL family Rieske PF00355.26 KPI87285.1 - 0.055 13.4 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain NTP_transf_2 PF01909.23 KPI87286.1 - 1.5e-07 31.6 0.0 2.6e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 KPI87286.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Proteasome PF00227.26 KPI87287.1 - 1.9e-24 86.2 0.4 7.4e-24 84.3 0.4 1.7 1 1 0 1 1 1 1 Proteasome subunit CDC73_C PF05179.14 KPI87288.1 - 2.2e-28 98.9 0.0 3.4e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal DEAD PF00270.29 KPI87288.1 - 0.07 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF3379 PF11859.8 KPI87289.1 - 0.2 11.0 0.6 0.44 9.8 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3379) PRR20 PF15708.5 KPI87292.1 - 0.0014 18.5 4.2 0.0028 17.6 4.2 1.5 1 0 0 1 1 1 1 Proline-rich protein family 20 DUF5320 PF17253.2 KPI87292.1 - 0.0066 17.5 2.1 0.0066 17.5 2.1 2.8 2 0 0 2 2 2 1 Family of unknown function (DUF5320) Bacillus_HBL PF05791.11 KPI87292.1 - 0.25 11.1 5.6 3.2 7.6 0.2 2.5 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) OmpH PF03938.14 KPI87292.1 - 2.6 8.4 22.1 2.8 8.3 0.0 3.4 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) FoP_duplication PF13865.6 KPI87292.1 - 3.1 8.4 20.3 0.3 11.7 15.0 2.1 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 DUF2316 PF10078.9 KPI87292.1 - 5.2 7.4 7.1 2.3 8.5 0.1 3.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) DUF5582 PF17819.1 KPI87293.1 - 0.64 10.5 1.9 1.2 9.5 1.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5582) Telomerase_RBD PF12009.8 KPI87294.1 - 5.8e-19 68.5 0.0 1.1e-18 67.7 0.0 1.5 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 KPI87294.1 - 0.00029 20.4 0.0 0.002 17.7 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) AdoHcyase PF05221.17 KPI87296.1 - 1.4e-130 434.8 0.0 1.7e-73 247.4 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KPI87296.1 - 7.7e-86 286.2 2.2 1.1e-85 285.6 2.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KPI87296.1 - 2.8e-10 39.8 0.0 5.4e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KPI87296.1 - 2.1e-05 24.2 0.1 3.8e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 KPI87296.1 - 8.5e-05 22.8 0.3 0.00042 20.6 0.3 2.2 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 KPI87296.1 - 0.00057 20.3 0.2 0.0014 19.0 0.2 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding PALP PF00291.25 KPI87296.1 - 0.005 16.3 0.8 0.013 14.9 0.3 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Oxidored_nitro PF00148.19 KPI87296.1 - 0.042 12.6 0.0 0.094 11.4 0.0 1.6 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.21 KPI87296.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase MAM33 PF02330.16 KPI87298.1 - 8.1e-08 32.5 0.2 1.7e-07 31.4 0.2 1.6 1 1 0 1 1 1 1 Mitochondrial glycoprotein Menin PF05053.13 KPI87298.1 - 0.017 13.6 0.3 0.024 13.0 0.3 1.1 1 0 0 1 1 1 0 Menin WD40 PF00400.32 KPI87299.1 - 1.4e-16 60.5 8.7 1.8e-05 25.4 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI87299.1 - 1.1e-09 38.5 0.0 1.1 9.6 0.0 5.2 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI87299.1 - 0.046 12.7 0.0 0.34 9.8 0.0 2.4 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein LRR_6 PF13516.6 KPI87300.1 - 0.027 14.5 0.2 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 Leucine Rich repeat THOC7 PF05615.13 KPI87300.1 - 0.044 14.1 4.0 0.11 12.8 4.0 1.7 1 0 0 1 1 1 0 Tho complex subunit 7 HAP2-GCS1 PF10699.9 KPI87301.1 - 2.4e-11 43.4 0.0 2.4e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 Male gamete fusion factor Snf7 PF03357.21 KPI87302.1 - 4.7e-31 107.7 30.5 7.6e-31 107.0 30.5 1.3 1 0 0 1 1 1 1 Snf7 Glyco_hydro_45 PF02015.16 KPI87302.1 - 0.05 13.5 0.1 0.075 12.9 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 FoP_duplication PF13865.6 KPI87302.1 - 1.5 9.4 8.3 1.6 9.3 0.5 2.6 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 DUF4407 PF14362.6 KPI87302.1 - 1.8 7.8 17.9 0.93 8.8 15.5 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HGTP_anticodon PF03129.20 KPI87303.1 - 7.5e-19 67.7 0.1 1.4e-18 66.8 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KPI87303.1 - 4.1e-06 26.9 0.0 3.2e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF3863 PF12979.7 KPI87304.1 - 0.061 12.2 0.4 0.097 11.5 0.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3863) Exonuc_VII_L PF02601.15 KPI87304.1 - 2.2 7.7 10.8 3.6 7.1 10.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit SOAR PF16533.5 KPI87304.1 - 7.6 6.6 10.1 10 6.2 7.8 2.2 2 0 0 2 2 2 0 STIM1 Orai1-activating region RRM_1 PF00076.22 KPI87306.1 - 2.9e-17 62.3 0.8 1e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI87306.1 - 0.0084 15.7 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC_membrane PF00664.23 KPI87307.1 - 3.2e-55 187.7 3.7 5.1e-55 187.1 3.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KPI87307.1 - 2e-32 112.6 0.0 3.2e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI87307.1 - 2.2e-05 24.0 0.1 0.022 14.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KPI87307.1 - 0.001 19.5 0.5 0.0069 16.8 0.5 2.1 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 KPI87307.1 - 0.0012 17.7 0.1 0.0028 16.5 0.2 1.4 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA PF00004.29 KPI87307.1 - 0.0013 19.1 0.3 0.11 12.9 0.1 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 KPI87307.1 - 0.0018 18.4 0.0 0.0062 16.6 0.0 1.7 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_5 PF07728.14 KPI87307.1 - 0.0067 16.4 0.1 0.1 12.6 0.0 2.6 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 KPI87307.1 - 0.012 15.5 0.0 0.3 11.0 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 KPI87307.1 - 0.015 15.6 0.3 0.37 11.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KPI87307.1 - 0.044 13.5 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3987 PF13148.6 KPI87307.1 - 0.061 12.3 0.3 0.13 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) DEAD PF00270.29 KPI87307.1 - 0.084 12.6 0.0 0.94 9.2 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase LSM14 PF12701.7 KPI87308.1 - 1.1e-27 95.9 0.1 1.6e-27 95.4 0.1 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 KPI87308.1 - 2.4e-06 27.6 0.1 4.3e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 KPI87308.1 - 0.0011 19.9 16.9 0.34 11.8 5.8 2.4 1 1 1 2 2 2 2 FDF domain DUF5578 PF17741.1 KPI87309.1 - 1.1e-15 57.8 0.5 3.6e-06 26.6 0.2 3.8 4 0 0 4 4 4 3 Family of unknown function (DUF5578) DUF3060 PF11259.8 KPI87309.1 - 1.3 8.7 4.6 0.24 11.1 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) DnaJ PF00226.31 KPI87310.1 - 0.015 15.4 0.0 0.029 14.5 0.0 1.5 1 0 0 1 1 1 0 DnaJ domain Y_phosphatase2 PF03162.13 KPI87311.1 - 6.7e-36 123.4 0.0 4.9e-27 94.5 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KPI87311.1 - 0.00027 21.0 0.0 0.0004 20.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PAW PF04721.17 KPI87312.1 - 0.089 12.6 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW DUF2475 PF10629.9 KPI87315.1 - 0.035 14.3 0.4 0.086 13.1 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2475) Raptor_N PF14538.6 KPI87316.1 - 2e-45 154.4 0.0 3.6e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 KPI87316.1 - 0.00033 20.7 1.4 0.16 12.3 0.1 3.1 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 KPI87316.1 - 0.052 13.9 0.3 0.27 11.7 0.0 2.3 2 1 0 2 2 2 0 HEAT repeats NopRA1 PF16201.5 KPI87316.1 - 0.075 12.6 0.8 1 8.9 0.1 2.7 3 0 0 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 RNA_pol_Rpb2_6 PF00562.28 KPI87317.1 - 1.5e-73 248.1 0.0 5.7e-73 246.2 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 KPI87317.1 - 6.3e-20 71.1 0.0 2.3e-19 69.3 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 KPI87317.1 - 3.9e-14 52.8 0.0 1.1e-13 51.3 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 KPI87317.1 - 4.2e-10 39.5 0.0 1.2e-09 38.0 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_1 PF04563.15 KPI87317.1 - 5.8e-07 29.2 0.0 4.6e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase beta subunit PqqD PF05402.12 KPI87317.1 - 0.058 13.7 0.3 2 8.8 0.0 3.1 2 1 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) zinc_ribbon_10 PF10058.9 KPI87317.1 - 0.096 12.4 0.1 0.28 10.9 0.1 1.7 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein RNA_pol_Rpb2_4 PF04566.13 KPI87317.1 - 0.11 12.8 0.0 0.59 10.5 0.0 2.3 1 1 0 1 1 1 0 RNA polymerase Rpb2, domain 4 FapA PF03961.13 KPI87317.1 - 0.19 10.3 0.0 1.3 7.5 0.0 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A PPR_long PF17177.4 KPI87318.1 - 0.00067 19.1 0.2 0.00096 18.6 0.2 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KPI87318.1 - 0.001 19.1 1.3 0.0036 17.4 0.0 2.3 2 0 0 2 2 2 1 PPR repeat PPR_2 PF13041.6 KPI87318.1 - 0.0042 17.3 0.4 0.012 15.7 0.0 2.0 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 KPI87318.1 - 0.1 12.7 0.2 0.23 11.6 0.2 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain GPS2_interact PF15784.5 KPI87319.1 - 0.009 16.4 0.1 0.29 11.6 0.0 2.2 2 0 0 2 2 2 1 G-protein pathway suppressor 2-interacting domain SusD_RagB PF07980.11 KPI87319.1 - 0.27 10.8 0.4 0.25 10.9 0.4 1.1 1 0 0 1 1 1 0 SusD family zf-AN1 PF01428.16 KPI87320.1 - 0.00013 22.0 29.2 0.0023 18.1 10.2 3.3 3 0 0 3 3 3 2 AN1-like Zinc finger DUF1375 PF07119.12 KPI87320.1 - 0.0021 18.4 0.1 0.029 14.8 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1375) Proho_convert PF12177.8 KPI87320.1 - 0.15 12.1 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Prohormone convertase enzyme zf-ribbon_3 PF13248.6 KPI87320.1 - 0.88 9.1 11.1 1.7 8.2 1.3 3.6 3 0 0 3 3 3 0 zinc-ribbon domain ENTH PF01417.20 KPI87322.1 - 2.7e-25 88.8 0.0 4.4e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 ENTH domain CCDC50_N PF15295.6 KPI87322.1 - 0.069 13.3 17.6 0.19 11.9 17.6 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Alpha_kinase PF02816.18 KPI87323.1 - 1.1e-54 185.4 0.0 2.9e-54 184.0 0.0 1.8 2 0 0 2 2 2 1 Alpha-kinase family DUF1682 PF07946.14 KPI87323.1 - 4.2e-05 22.9 18.5 6.4e-05 22.3 18.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) POX PF07526.11 KPI87323.1 - 0.14 12.8 4.6 0.63 10.6 4.6 2.1 1 0 0 1 1 1 0 Associated with HOX Peptidase_S9 PF00326.21 KPI87326.1 - 0.0083 15.6 0.0 0.026 14.0 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KPI87326.1 - 0.0098 15.2 0.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI87326.1 - 0.79 10.3 12.4 2.5 8.6 7.7 3.1 2 1 0 2 2 2 0 Alpha/beta hydrolase family SCAMP PF04144.13 KPI87327.1 - 1.3e-31 110.2 11.0 1.7e-31 109.9 11.0 1.1 1 0 0 1 1 1 1 SCAMP family FYVE_2 PF02318.16 KPI87327.1 - 0.088 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger Thioredoxin PF00085.20 KPI87328.1 - 1.4e-23 82.9 0.0 2.4e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 KPI87328.1 - 1.3e-06 28.2 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KPI87328.1 - 1.7e-06 28.4 0.0 5.7e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KPI87328.1 - 0.0015 18.8 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 KPI87328.1 - 0.003 16.9 0.1 0.004 16.6 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 KPI87328.1 - 0.03 14.5 0.0 0.047 13.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 KPI87328.1 - 0.038 13.7 0.3 0.28 10.9 0.2 1.9 1 1 1 2 2 2 0 Redoxin CHAP PF05257.16 KPI87330.1 - 3.7e-15 56.3 0.0 7e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 CHAP domain Peptidase_S24 PF00717.23 KPI87330.1 - 0.17 11.8 0.1 0.46 10.5 0.1 1.7 1 1 0 1 1 1 0 Peptidase S24-like PWWP PF00855.17 KPI87331.1 - 2e-07 31.3 0.0 2e-07 31.3 0.0 2.2 2 0 0 2 2 2 1 PWWP domain Med26 PF08711.11 KPI87331.1 - 2.8e-05 24.1 0.6 0.0001 22.3 0.0 2.2 2 0 0 2 2 1 1 TFIIS helical bundle-like domain Zn_ribbon_SprT PF17283.2 KPI87331.1 - 4.6e-05 23.2 0.5 0.00012 22.0 0.5 1.8 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Lar_restr_allev PF14354.6 KPI87331.1 - 0.0013 19.1 1.3 0.005 17.2 0.4 2.4 2 0 0 2 2 2 1 Restriction alleviation protein Lar TFIIS_C PF01096.18 KPI87331.1 - 0.0056 16.5 1.0 0.014 15.2 1.0 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 KPI87331.1 - 0.043 13.8 0.5 0.11 12.5 0.5 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 KPI87331.1 - 0.075 13.0 0.7 3 7.8 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 KPI87331.1 - 0.084 12.8 0.9 0.2 11.6 0.9 1.6 1 0 0 1 1 1 0 PhnA Zinc-Ribbon TF_Zn_Ribbon PF08271.12 KPI87331.1 - 0.11 12.0 0.2 0.54 9.8 0.3 2.2 2 1 0 2 2 2 0 TFIIB zinc-binding Vps36-NZF-N PF16988.5 KPI87331.1 - 0.16 11.4 0.5 0.43 10.0 0.5 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-RING_7 PF02591.15 KPI87331.1 - 0.43 10.8 1.8 3 8.1 0.1 3.1 3 0 0 3 3 3 0 C4-type zinc ribbon domain Zn-ribbon_8 PF09723.10 KPI87331.1 - 0.57 10.4 2.9 12 6.1 2.8 2.8 1 1 1 2 2 2 0 Zinc ribbon domain FAM60A PF15396.6 KPI87331.1 - 1.8 8.5 9.7 3.7 7.5 9.7 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF3827 PF12877.7 KPI87331.1 - 2.5 6.3 9.4 3.5 5.9 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DNA_RNApol_7kD PF03604.13 KPI87331.1 - 3.3 7.5 4.7 40 4.0 4.7 2.5 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit zf-ribbon_3 PF13248.6 KPI87331.1 - 5.1 6.7 7.2 1 8.8 0.2 3.1 4 0 0 4 4 4 0 zinc-ribbon domain TFIIS_C PF01096.18 KPI87332.1 - 7.1e-15 54.6 4.9 1.1e-14 54.0 4.9 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) PWWP PF00855.17 KPI87332.1 - 9e-08 32.4 1.0 2.3e-07 31.1 0.0 2.2 2 1 0 2 2 2 1 PWWP domain Med26 PF08711.11 KPI87332.1 - 0.011 15.7 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 TFIIS helical bundle-like domain DUF2536 PF10750.9 KPI87333.1 - 0.096 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2536) GTP_EFTU PF00009.27 KPI87334.1 - 1.1e-18 67.5 0.0 1.5e-17 63.8 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KPI87334.1 - 2.3e-06 27.9 0.3 7.2e-06 26.3 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 KPI87334.1 - 0.00027 21.2 3.2 0.0041 17.4 3.2 2.5 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 KPI87334.1 - 0.012 15.7 0.0 0.058 13.5 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 KPI87334.1 - 0.033 13.9 0.1 3 7.6 0.0 3.1 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Beach PF02138.18 KPI87335.1 - 1.8e-94 316.2 0.0 2.8e-94 315.5 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain Laminin_G_3 PF13385.6 KPI87335.1 - 2.3e-11 44.1 0.5 5e-11 43.0 0.5 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily UQ_con PF00179.26 KPI87336.1 - 4.5e-35 120.3 0.0 6.2e-35 119.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF2989 PF11207.8 KPI87337.1 - 0.042 13.6 0.2 0.076 12.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) DUF4520 PF15016.6 KPI87338.1 - 7.3e-17 61.2 0.3 1.9e-14 53.5 0.0 3.2 4 0 0 4 4 4 2 Domain of unknown function (DUF4520) GTP_EFTU PF00009.27 KPI87339.1 - 5.2e-34 117.5 1.5 7.9e-34 116.9 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KPI87339.1 - 2.8e-15 56.3 0.0 7.5e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 KPI87339.1 - 2.3e-10 40.7 0.7 2e-07 31.3 0.0 3.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KPI87339.1 - 7.9e-08 32.4 0.0 6e-07 29.6 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KPI87339.1 - 2.5e-07 30.5 1.0 6.2e-07 29.2 1.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Roc PF08477.13 KPI87339.1 - 0.00025 21.2 0.0 0.00058 20.1 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase HlyD_D4 PF16572.5 KPI87339.1 - 0.017 15.0 0.9 0.042 13.7 0.9 1.6 1 0 0 1 1 1 0 Long alpha hairpin domain of cation efflux system protein, CusB Ras PF00071.22 KPI87339.1 - 0.022 14.4 0.0 0.12 12.0 0.0 2.2 1 1 0 1 1 1 0 Ras family RsgA_GTPase PF03193.16 KPI87339.1 - 0.026 14.4 0.7 3.7 7.4 0.1 3.2 1 1 1 2 2 2 0 RsgA GTPase TFIIA PF03153.13 KPI87342.1 - 7.7 6.4 17.1 9.7 6.1 17.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.22 KPI87343.1 - 0.00028 20.6 0.0 0.012 15.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_60s PF00428.19 KPI87343.1 - 9 7.0 10.0 51 4.5 0.1 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein ketoacyl-synt PF00109.26 KPI87344.1 - 2.3e-39 135.5 2.8 3.4e-38 131.7 2.8 2.4 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KPI87344.1 - 7e-27 93.8 0.3 1.3e-26 92.9 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain DUF1542 PF07564.11 KPI87344.1 - 0.21 11.7 0.0 0.41 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Complex1_LYR PF05347.15 KPI87345.1 - 9.2e-06 25.6 0.9 1.5e-05 24.9 0.9 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KPI87345.1 - 0.086 13.6 0.2 0.12 13.2 0.2 1.2 1 0 0 1 1 1 0 Complex1_LYR-like MCM PF00493.23 KPI87346.1 - 7.4e-84 280.3 0.0 1.3e-83 279.5 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KPI87346.1 - 7.1e-27 93.8 0.0 1.4e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KPI87346.1 - 8.3e-22 77.4 0.0 1.7e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KPI87346.1 - 6.8e-10 39.5 0.0 2e-08 34.7 0.0 2.7 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 KPI87346.1 - 3.1e-08 33.3 0.2 6e-07 29.1 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KPI87346.1 - 0.0004 20.1 0.1 0.0016 18.2 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 KPI87346.1 - 0.001 18.9 0.0 0.0022 17.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 KPI87346.1 - 0.11 12.9 0.0 0.57 10.6 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2150 PF09920.9 KPI87347.1 - 0.012 15.6 0.2 0.048 13.6 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) DUF4201 PF13870.6 KPI87348.1 - 0.02 14.6 0.8 0.033 13.9 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) SlyX PF04102.12 KPI87348.1 - 0.31 11.7 2.5 1.7 9.3 0.0 2.7 1 1 2 3 3 3 0 SlyX sCache_like PF16736.5 KPI87348.1 - 0.85 9.7 3.4 1 9.5 0.3 2.1 2 0 0 2 2 2 0 Single Cache-like sCache_2 PF17200.4 KPI87349.1 - 0.16 11.8 3.6 0.7 9.7 0.2 2.4 2 0 0 2 2 2 0 Single Cache domain 2 YabA PF06156.13 KPI87349.1 - 6.2 7.5 11.1 0.71 10.5 0.2 3.2 3 1 0 3 3 3 0 Initiation control protein YabA Leu_zip PF15294.6 KPI87349.1 - 6.9 6.1 12.1 1.4 8.4 0.1 2.2 2 0 0 2 2 2 0 Leucine zipper ARGLU PF15346.6 KPI87349.1 - 8.6 6.2 22.7 0.53 10.1 16.7 2.0 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 DUF2870 PF11069.8 KPI87350.1 - 1.6e-22 79.7 0.1 1e-21 77.1 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2870) DUF4315 PF14193.6 KPI87350.1 - 0.0011 18.9 1.0 1.1 9.3 0.0 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4315) MSP PF01716.18 KPI87350.1 - 0.032 13.4 0.0 0.041 13.1 0.0 1.1 1 0 0 1 1 1 0 Manganese-stabilising protein / photosystem II polypeptide NUC173 PF08161.12 KPI87350.1 - 0.068 12.8 0.2 0.57 9.8 0.0 2.0 2 0 0 2 2 2 0 NUC173 domain SMAP PF15477.6 KPI87351.1 - 7e-12 46.1 6.1 1.9e-11 44.7 6.1 1.7 1 0 0 1 1 1 1 Small acidic protein family zf-HC2 PF13490.6 KPI87351.1 - 0.39 11.0 5.8 0.56 10.5 0.3 2.7 2 0 0 2 2 2 0 Putative zinc-finger Transket_pyr PF02779.24 KPI87352.1 - 8.1e-52 175.5 0.2 2.2e-51 174.1 0.0 1.9 3 0 0 3 3 3 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KPI87352.1 - 3.4e-49 167.4 0.1 5.7e-49 166.7 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 KPI87352.1 - 1.2e-42 145.2 0.0 2.3e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KPI87352.1 - 5.7e-14 51.4 0.7 1.2e-13 50.4 0.7 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus NIPSNAP PF07978.13 KPI87353.1 - 8.8e-19 67.6 0.0 2.5e-18 66.2 0.0 1.7 2 0 0 2 2 2 1 NIPSNAP Glyco_transf_25 PF01755.17 KPI87354.1 - 2.3e-13 50.5 0.0 1.2e-06 28.6 0.0 3.1 2 1 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) Snf7 PF03357.21 KPI87355.1 - 1.9e-29 102.5 30.4 1.9e-29 102.5 30.4 2.0 1 1 1 2 2 2 2 Snf7 CRAL_TRIO PF00650.20 KPI87356.1 - 4.1e-26 91.6 0.0 6.4e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KPI87356.1 - 0.044 13.9 0.0 0.091 12.9 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Vps26 PF03643.15 KPI87357.1 - 2.3e-53 181.0 0.6 2.8e-53 180.7 0.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KPI87357.1 - 0.00084 19.4 0.5 0.34 11.0 0.4 3.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain CcmF_C PF16327.5 KPI87357.1 - 0.18 11.1 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal adh_short PF00106.25 KPI87358.1 - 1.4e-37 129.1 0.0 1.7e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI87358.1 - 1.6e-16 60.6 0.1 2.1e-16 60.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI87358.1 - 1.7e-08 34.6 0.5 1.6e-07 31.4 0.5 2.1 1 1 0 1 1 1 1 KR domain Pyr_redox PF00070.27 KPI87358.1 - 0.00026 21.5 0.4 0.00052 20.5 0.4 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KPI87358.1 - 0.0075 15.5 0.2 0.014 14.7 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KPI87358.1 - 0.057 13.3 0.1 0.092 12.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 KPI87358.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Methyltransf_31 PF13847.6 KPI87358.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_L29e PF01779.17 KPI87359.1 - 1.6e-11 44.3 8.0 1.6e-11 44.3 8.0 1.9 2 0 0 2 2 2 1 Ribosomal L29e protein family Ribosomal_L29e PF01779.17 KPI87360.1 - 1.6e-11 44.3 8.0 1.6e-11 44.3 8.0 1.9 2 0 0 2 2 2 1 Ribosomal L29e protein family WASH_WAHD PF11945.8 KPI87362.1 - 0.0035 16.9 0.0 0.0036 16.9 0.0 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex Amidohydro_2 PF04909.14 KPI87362.1 - 0.053 13.3 0.1 0.055 13.2 0.1 1.0 1 0 0 1 1 1 0 Amidohydrolase Bromodomain PF00439.25 KPI87363.1 - 8.4e-15 54.6 0.1 2.1e-14 53.4 0.1 1.7 1 0 0 1 1 1 1 Bromodomain Cast PF10174.9 KPI87364.1 - 0.00049 18.5 0.5 0.00054 18.3 0.5 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone OCRL_clath_bd PF16726.5 KPI87364.1 - 0.0081 16.3 0.0 0.0098 16.1 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate 5-phosphatase clathrin binding domain RBD-FIP PF09457.10 KPI87364.1 - 0.15 12.0 0.5 0.28 11.1 0.1 1.6 2 0 0 2 2 2 0 FIP domain Piezo_RRas_bdg PF12166.8 KPI87366.1 - 9.2e-81 272.3 0.0 1.3e-80 271.8 0.0 1.3 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain Actin PF00022.19 KPI87369.1 - 6e-91 305.1 0.0 3.6e-90 302.5 0.0 1.8 1 1 0 1 1 1 1 Actin FtsA PF14450.6 KPI87369.1 - 0.081 13.4 0.0 0.54 10.7 0.0 2.1 2 1 0 2 2 2 0 Cell division protein FtsA Macro PF01661.21 KPI87372.1 - 0.0067 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Macro domain ECH_2 PF16113.5 KPI87373.1 - 5.3e-20 72.2 0.0 3e-11 43.4 0.0 4.0 3 1 0 3 3 3 2 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KPI87373.1 - 1e-10 41.4 0.0 3.5e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase Ribosomal_L22e PF01776.17 KPI87374.1 - 6.4e-36 123.0 4.5 8.4e-36 122.7 4.5 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Asparaginase PF00710.20 KPI87375.1 - 4.8e-38 130.6 0.0 8.6e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 KPI87375.1 - 2.2e-25 89.1 0.0 3.3e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain TPR_17 PF13431.6 KPI87376.1 - 1.3e-05 25.2 1.1 0.014 15.7 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87376.1 - 0.00043 20.7 0.1 0.25 11.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87376.1 - 0.054 13.6 0.3 0.37 11.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI87376.1 - 0.074 13.3 1.1 12 6.2 0.1 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KPI87376.1 - 0.077 13.8 1.6 10 7.2 0.3 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Hormone_recep PF00104.30 KPI87376.1 - 0.089 12.4 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor TPR_20 PF14561.6 KPI87376.1 - 0.11 12.8 0.1 0.28 11.5 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87376.1 - 0.14 11.8 0.2 0.49 10.1 0.1 2.0 2 0 0 2 2 2 0 TPR repeat Peptidase_M3 PF01432.20 KPI87377.1 - 2.1e-70 238.3 0.6 8.6e-55 186.8 0.3 2.0 2 0 0 2 2 2 2 Peptidase family M3 Peptidase_M32 PF02074.15 KPI87377.1 - 0.0073 15.1 0.4 0.018 13.9 0.4 1.5 2 0 0 2 2 2 1 Carboxypeptidase Taq (M32) metallopeptidase Ish1 PF10281.9 KPI87378.1 - 0.088 13.1 0.0 22 5.4 0.0 2.5 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Acyl-CoA_dh_1 PF00441.24 KPI87378.1 - 0.54 10.5 4.3 7.1 6.8 0.7 2.2 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain DnaJ PF00226.31 KPI87379.1 - 3.8e-21 75.0 0.0 9.8e-21 73.7 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain DUF4817 PF16087.5 KPI87379.1 - 0.0039 17.0 0.2 0.025 14.4 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix domain (DUF4817) Spectrin_like PF18373.1 KPI87379.1 - 1.3 9.2 3.6 5.2 7.2 1.1 2.4 2 0 0 2 2 2 0 Spectrin like domain Aa_trans PF01490.18 KPI87380.1 - 1.4e-41 142.5 13.8 6.4e-37 127.2 1.0 2.8 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein DUF4131 PF13567.6 KPI87380.1 - 9.7 5.8 9.6 0.85 9.3 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MTS PF05175.14 KPI87381.1 - 3.2e-13 49.6 0.5 1e-10 41.4 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_31 PF13847.6 KPI87381.1 - 3.1e-08 33.6 0.0 6.8e-08 32.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI87381.1 - 3.2e-08 34.2 0.0 8.7e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KPI87381.1 - 3.6e-07 29.9 0.4 6.3e-07 29.1 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KPI87381.1 - 0.00014 22.5 0.1 0.00076 20.2 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 KPI87381.1 - 0.00047 20.0 0.0 0.00072 19.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Ubie_methyltran PF01209.18 KPI87381.1 - 0.00076 18.9 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.18 KPI87381.1 - 0.00081 18.9 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_11 PF08241.12 KPI87381.1 - 0.0016 19.0 0.0 0.0041 17.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 KPI87381.1 - 0.0017 18.0 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_16 PF10294.9 KPI87381.1 - 0.0018 18.1 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_18 PF12847.7 KPI87381.1 - 0.0044 17.0 0.1 0.0084 16.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI87381.1 - 0.0078 16.1 0.0 0.031 14.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 KPI87381.1 - 0.011 15.2 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.6 KPI87381.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 KPI87381.1 - 0.019 14.0 0.1 0.04 12.9 0.1 1.4 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase TRM PF02005.16 KPI87381.1 - 0.04 13.1 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase AviRa PF11599.8 KPI87381.1 - 0.045 13.2 0.0 0.08 12.4 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa N6_Mtase PF02384.16 KPI87381.1 - 0.078 12.2 0.0 0.16 11.2 0.0 1.5 1 1 0 1 1 1 0 N-6 DNA Methylase Asparaginase_2 PF01112.18 KPI87381.1 - 0.15 11.1 0.2 0.36 9.8 0.1 1.6 2 0 0 2 2 2 0 Asparaginase UPF0020 PF01170.18 KPI87381.1 - 1.9 8.2 3.8 69 3.0 3.8 2.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF2870 PF11069.8 KPI87382.1 - 2.5e-35 120.7 1.4 2.8e-35 120.6 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) DUF4633 PF15464.6 KPI87382.1 - 0.12 12.5 0.3 3 8.0 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4633) Thiolase_N PF00108.23 KPI87383.1 - 2.2e-56 191.1 1.8 3.9e-56 190.3 1.8 1.4 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KPI87383.1 - 4.2e-33 113.6 0.0 1.2e-32 112.1 0.0 1.9 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KPI87383.1 - 2.1e-08 34.1 0.9 5.6e-08 32.7 0.6 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KPI87383.1 - 0.0009 19.0 1.2 0.024 14.5 0.4 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SpoVAD PF07451.11 KPI87383.1 - 0.0014 17.4 0.3 0.0036 16.1 0.2 1.7 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) FAE1_CUT1_RppA PF08392.12 KPI87383.1 - 0.0066 15.8 0.3 0.02 14.2 0.3 1.7 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein Pr_beta_C PF12465.8 KPI87383.1 - 0.16 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Proteasome beta subunits C terminal NTPase_I-T PF01931.18 KPI87384.1 - 2.8e-54 183.3 0.0 3.2e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 TP_methylase PF00590.20 KPI87385.1 - 3.1e-21 76.3 0.0 5.1e-21 75.6 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Ribosomal_L36 PF00444.18 KPI87386.1 - 0.0014 18.7 0.2 0.0032 17.6 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L36 GCM PF03615.15 KPI87387.1 - 0.1 12.5 2.3 0.45 10.4 2.2 1.8 1 1 0 1 1 1 0 GCM motif protein CX9C PF16860.5 KPI87387.1 - 0.92 9.6 4.5 13 5.9 0.7 2.6 2 1 1 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, L51_S25_CI-B8 PF05047.16 KPI87390.1 - 1.5e-10 40.8 0.0 3.3e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain LysR_substrate PF03466.20 KPI87390.1 - 0.085 12.2 0.1 0.18 11.1 0.1 1.5 1 0 0 1 1 1 0 LysR substrate binding domain Pkinase PF00069.25 KPI87392.1 - 1.9e-40 138.9 0.0 1.7e-28 99.7 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87392.1 - 4e-18 65.6 0.0 9e-17 61.2 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase PH_3 PF14593.6 KPI87392.1 - 0.00057 20.0 0.0 0.0044 17.1 0.0 2.1 1 1 0 1 1 1 1 PH domain Guanylate_cyc PF00211.20 KPI87396.1 - 1.4e-19 70.5 0.0 3.1e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain FAD_binding_8 PF08022.12 KPI87396.1 - 0.12 12.5 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 FAD-binding domain LRR_4 PF12799.7 KPI87398.1 - 1.1e-15 57.5 9.8 0.23 12.0 0.0 9.5 9 0 0 9 9 9 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87398.1 - 2.4e-07 30.4 11.8 0.13 12.1 0.0 8.2 8 1 1 10 10 10 4 Leucine rich repeat LRR_6 PF13516.6 KPI87398.1 - 1.8e-05 24.4 16.0 0.09 12.9 0.1 10.1 12 1 1 13 13 13 3 Leucine Rich repeat LRR_8 PF13855.6 KPI87399.1 - 9.6e-21 73.3 2.8 4e-06 26.5 0.0 4.8 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KPI87399.1 - 4.3e-13 49.2 0.8 8.2e-05 22.9 0.0 5.2 2 1 4 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI87399.1 - 0.00018 21.6 0.1 9.7 7.2 0.0 6.2 8 0 0 8 8 8 1 Leucine Rich Repeat DUF3304 PF11745.8 KPI87399.1 - 0.16 12.4 3.4 11 6.5 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3304) LRRNT_2 PF08263.12 KPI87399.1 - 0.83 10.0 12.2 0.87 9.9 0.1 4.3 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 KPI87399.1 - 1.1 9.5 7.6 15 6.0 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich repeat DUF237 PF03072.14 KPI87399.1 - 1.4 9.0 4.0 91 3.1 0.0 4.8 3 3 1 5 5 5 0 Domain of unknown function (DUF237) Dpy-30 PF05186.13 KPI87401.1 - 1.4e-06 27.9 0.3 0.0033 17.1 0.1 2.2 2 0 0 2 2 2 2 Dpy-30 motif Importin_rep_4 PF18808.1 KPI87403.1 - 2.9e-14 53.1 10.5 8.8e-14 51.6 0.0 4.3 4 1 0 4 4 4 2 Importin repeat HEAT PF02985.22 KPI87403.1 - 2.7e-08 33.4 13.3 0.019 15.2 0.2 7.3 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 KPI87403.1 - 1.6e-06 28.5 9.8 3.7 8.1 0.3 5.9 6 0 0 6 6 6 4 HEAT-like repeat Cnd1 PF12717.7 KPI87403.1 - 3.3e-05 24.0 0.3 0.00035 20.6 0.1 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KPI87403.1 - 8.5e-05 22.9 4.4 0.0018 18.7 0.1 4.9 6 0 0 6 6 6 1 HEAT repeats MMS19_C PF12460.8 KPI87403.1 - 0.011 14.9 1.5 22 4.0 0.0 3.6 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 KPI87403.1 - 0.021 13.4 0.6 0.32 9.5 0.3 2.8 2 1 0 2 2 2 0 Adaptin N terminal region Ku_PK_bind PF08785.11 KPI87403.1 - 0.038 14.1 0.4 5.2 7.2 0.0 3.4 3 0 0 3 3 3 0 Ku C terminal domain like RRM_1 PF00076.22 KPI87405.1 - 1.7e-06 27.8 0.0 2.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 KPI87405.1 - 0.00056 20.3 0.8 0.00056 20.3 0.8 1.8 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 OspD PF03207.13 KPI87405.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) E1-E2_ATPase PF00122.20 KPI87406.1 - 0.69 9.4 4.2 0.23 10.9 0.4 2.2 2 0 0 2 2 2 0 E1-E2 ATPase baeRF_family7 PF18849.1 KPI87407.1 - 0.13 12.5 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 MbeD_MobD PF04899.12 KPI87408.1 - 0.012 15.7 3.2 0.012 15.7 3.2 3.3 3 1 1 4 4 4 0 MbeD/MobD like GspH PF12019.8 KPI87408.1 - 0.068 13.6 1.8 0.32 11.4 1.2 2.5 2 0 0 2 2 2 0 Type II transport protein GspH Cytochrom_B562 PF07361.11 KPI87408.1 - 0.92 10.2 6.9 3.4 8.4 6.9 2.0 1 0 0 1 1 1 0 Cytochrome b562 DUF5320 PF17253.2 KPI87408.1 - 1.1 10.4 11.7 9.5 7.4 0.0 4.4 4 0 0 4 4 4 0 Family of unknown function (DUF5320) LPP PF04728.13 KPI87408.1 - 3.4 8.1 9.5 6.5 7.2 1.4 3.9 2 1 0 2 2 2 0 Lipoprotein leucine-zipper AAA_13 PF13166.6 KPI87408.1 - 4.8 5.7 10.5 3 6.4 8.4 1.6 2 0 0 2 2 2 0 AAA domain Macoilin PF09726.9 KPI87408.1 - 7.3 5.0 14.7 5.1 5.5 12.0 2.1 2 0 0 2 2 2 0 Macoilin family Cons_hypoth95 PF03602.15 KPI87409.1 - 0.11 12.1 0.0 0.34 10.5 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein 95 dCMP_cyt_deam_1 PF00383.23 KPI87410.1 - 4.8e-07 29.6 0.0 1.1e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KPI87410.1 - 1.7e-05 24.6 0.0 2.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 KPI87410.1 - 0.014 15.5 0.0 0.048 13.7 0.0 1.9 2 0 0 2 2 2 0 Bd3614-like deaminase Acetyltransf_1 PF00583.25 KPI87411.1 - 3.8e-18 65.8 0.1 2.1e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KPI87411.1 - 1.6e-14 54.0 0.0 2.5e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI87411.1 - 4.1e-11 43.1 0.1 2.3e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI87411.1 - 0.028 14.4 0.0 0.29 11.2 0.0 2.2 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_10 PF13673.7 KPI87412.1 - 6.6e-26 90.7 0.0 3.5e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI87412.1 - 1.4e-25 89.8 0.0 1.8e-11 44.3 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI87412.1 - 1.9e-20 73.1 0.0 2.1e-09 37.6 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI87412.1 - 2.5e-07 30.6 0.0 0.017 15.1 0.0 2.4 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_4 PF13420.7 KPI87412.1 - 5.6e-07 29.8 0.0 0.033 14.3 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KPI87412.1 - 0.00065 19.8 0.0 0.38 10.9 0.0 2.5 2 0 0 2 2 2 2 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 KPI87412.1 - 0.0018 18.4 0.1 0.27 11.3 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF3986 PF13143.6 KPI87412.1 - 0.088 13.8 0.1 12 7.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3986) CTP_transf_like PF01467.26 KPI87413.1 - 2.6e-05 24.4 0.0 3.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like ABC_tran PF00005.27 KPI87414.1 - 2.6e-19 70.1 0.0 4.8e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KPI87414.1 - 4.4e-10 39.7 6.8 6.8e-10 39.1 6.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 KPI87414.1 - 7.1e-10 39.2 0.0 2.4e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI87414.1 - 8.6e-08 31.9 0.1 1.1e-06 28.3 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KPI87414.1 - 0.002 17.8 0.1 0.0045 16.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KPI87414.1 - 0.0044 17.3 0.2 0.034 14.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 KPI87414.1 - 0.011 15.9 0.1 0.077 13.2 0.0 2.3 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 KPI87414.1 - 0.014 15.8 0.0 0.038 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 KPI87414.1 - 0.02 15.4 0.1 0.035 14.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KPI87414.1 - 0.066 13.1 0.0 0.19 11.6 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase DASH_Dad1 PF08649.10 KPI87414.1 - 0.068 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 DASH complex subunit Dad1 MMR_HSR1 PF01926.23 KPI87414.1 - 0.14 12.2 0.0 0.42 10.7 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 KPI87414.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 KPI87414.1 - 0.19 12.2 0.3 1.9 8.9 0.3 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNARE_assoc PF09335.11 KPI87414.1 - 0.63 10.5 5.0 0.87 10.1 2.8 2.4 2 1 0 2 2 2 0 SNARE associated Golgi protein DUF5617 PF18493.1 KPI87415.1 - 0.00073 19.6 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5617) DUF2052 PF09747.9 KPI87416.1 - 0.73 9.9 9.2 0.86 9.7 7.3 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Folliculin PF11704.8 KPI87416.1 - 0.91 9.4 11.6 0.2 11.5 6.7 2.4 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 KPI87416.1 - 4.6 5.9 6.9 10 4.8 6.9 1.6 1 0 0 1 1 1 0 Presenilin Ras PF00071.22 KPI87417.1 - 1.9e-60 203.1 0.1 2.2e-60 202.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI87417.1 - 4.2e-33 114.1 0.0 6.8e-33 113.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI87417.1 - 2.3e-12 46.7 0.0 2.7e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KPI87417.1 - 0.00017 21.5 0.0 0.21 11.5 0.0 2.6 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 KPI87417.1 - 0.00022 21.3 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI87417.1 - 0.00027 20.5 0.1 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KPI87417.1 - 0.0006 19.2 0.0 0.00077 18.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KPI87417.1 - 0.023 15.0 0.1 0.096 13.0 0.0 2.0 1 1 1 2 2 2 0 AAA domain TetR_C_16 PF17920.1 KPI87417.1 - 0.048 13.9 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DAP3 PF10236.9 KPI87417.1 - 0.06 12.5 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 KPI87417.1 - 0.11 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 KPI87417.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain EMP24_GP25L PF01105.24 KPI87418.1 - 1.2e-36 126.3 0.0 1.5e-36 126.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3456 PF11938.8 KPI87420.1 - 2.5e-19 70.3 0.1 1.7e-18 67.7 0.0 2.0 2 0 0 2 2 2 1 TLR4 regulator and MIR-interacting MSAP MgpC PF05220.12 KPI87420.1 - 0.088 12.1 0.7 0.14 11.5 0.7 1.2 1 0 0 1 1 1 0 MgpC protein precursor Endosulfine PF04667.17 KPI87421.1 - 0.00059 19.9 6.1 0.00062 19.9 5.3 1.6 1 1 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Spt20 PF12090.8 KPI87421.1 - 2.1 7.9 12.8 2.3 7.7 12.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF4200 PF13863.6 KPI87422.1 - 2.7e-20 73.0 16.5 2.7e-20 73.0 16.5 4.9 4 1 0 4 4 4 1 Domain of unknown function (DUF4200) UPF0242 PF06785.11 KPI87422.1 - 0.017 15.2 0.3 0.017 15.2 0.3 4.2 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus XhlA PF10779.9 KPI87422.1 - 0.42 10.8 7.7 5.5 7.3 1.7 3.3 2 0 0 2 2 2 0 Haemolysin XhlA Spherulin4 PF12138.8 KPI87422.1 - 0.84 9.2 2.7 5.4 6.6 0.4 2.4 2 0 0 2 2 2 0 Spherulation-specific family 4 Ribo_biogen_C PF04034.13 KPI87424.1 - 4e-49 165.6 0.0 5.2e-49 165.2 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 KPI87424.1 - 1.5e-11 43.9 0.0 2.8e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Acyltransferase PF01553.21 KPI87426.1 - 4e-15 55.6 0.1 1e-14 54.3 0.0 1.7 2 0 0 2 2 2 1 Acyltransferase baeRF_family3 PF18845.1 KPI87426.1 - 0.03 14.6 0.2 0.045 14.0 0.2 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 Clr2_transil PF16761.5 KPI87426.1 - 0.059 14.2 0.0 0.13 13.1 0.0 1.5 1 0 0 1 1 1 0 Transcription-silencing protein, cryptic loci regulator Clr2 DnaJ_C PF01556.18 KPI87428.1 - 1.3e-32 112.9 0.0 1.7e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI87428.1 - 4.4e-15 55.5 0.4 7.1e-15 54.9 0.4 1.3 1 0 0 1 1 1 1 DnaJ domain JMY PF15871.5 KPI87429.1 - 0.0015 17.9 1.3 0.0015 17.9 1.3 1.6 2 0 0 2 2 2 1 Junction-mediating and -regulatory protein DUF647 PF04884.14 KPI87430.1 - 1.5e-26 93.5 8.6 2.1e-26 93.0 8.6 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF647 PF04884.14 KPI87431.1 - 2.6e-35 122.2 7.4 3.9e-35 121.6 7.4 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis SnoaL_3 PF13474.6 KPI87433.1 - 9.9e-31 106.5 2.3 1.2e-30 106.2 2.3 1.1 1 0 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.10 KPI87433.1 - 0.0016 18.6 0.9 0.017 15.2 0.1 2.1 1 1 1 2 2 2 1 Calcium/calmodulin dependent protein kinase II association domain DUF4440 PF14534.6 KPI87433.1 - 0.014 15.8 2.6 0.07 13.5 2.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) Prominin PF05478.11 KPI87434.1 - 0.11 10.4 2.3 0.12 10.3 1.3 1.5 2 0 0 2 2 2 0 Prominin TPR_12 PF13424.6 KPI87436.1 - 0.0033 17.7 3.9 1.4 9.3 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87436.1 - 0.042 14.7 0.2 0.042 14.7 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87436.1 - 0.14 12.7 2.7 1.9 9.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ADH_zinc_N_2 PF13602.6 KPI87437.1 - 1.6e-15 58.3 0.0 3.4e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI87437.1 - 2.4e-10 40.3 0.6 1.8e-09 37.4 0.1 2.4 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI87437.1 - 1.5e-09 37.9 0.0 9.5e-09 35.3 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glyco_hydro_32C PF08244.12 KPI87438.1 - 5.7e-21 75.2 0.0 7.4e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Glyco_hydro_32N PF00251.20 KPI87438.1 - 1.3e-16 61.1 0.0 2e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32N PF00251.20 KPI87439.1 - 9.8e-37 127.1 6.5 1.4e-36 126.6 6.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32N PF00251.20 KPI87440.1 - 4.6e-21 75.7 0.0 5.2e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Methyltransf_28 PF02636.17 KPI87441.1 - 1.2e-59 202.1 0.0 1.6e-59 201.6 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase SNF2_N PF00176.23 KPI87444.1 - 4.7e-39 134.1 0.0 1.9e-38 132.1 0.0 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI87444.1 - 5.9e-08 33.0 0.0 2.3e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 KPI87444.1 - 0.14 12.5 0.0 0.71 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain SWI2_SNF2 PF18766.1 KPI87444.1 - 0.16 11.6 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Peptidase_M17 PF00883.21 KPI87446.1 - 1.8e-101 339.6 0.0 2.9e-101 338.8 0.0 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 KPI87446.1 - 0.03 14.2 0.5 0.21 11.5 0.0 2.6 3 1 0 3 3 3 0 Cytosol aminopeptidase family, N-terminal domain CHB_HEX_C_1 PF13290.6 KPI87447.1 - 2.5e-07 30.6 2.8 0.002 18.1 0.1 4.2 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 KPI87447.1 - 7.1e-07 29.3 0.5 0.12 12.6 0.0 4.6 4 0 0 4 4 4 2 Fn3 associated Auxin_repressed PF05564.12 KPI87447.1 - 0.067 13.9 0.0 0.29 11.8 0.0 2.1 2 0 0 2 2 2 0 Dormancy/auxin associated protein EphA2_TM PF14575.6 KPI87447.1 - 0.13 13.1 0.0 0.35 11.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TerB PF05099.13 KPI87448.1 - 0.056 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Tellurite resistance protein TerB ORC3_N PF07034.11 KPI87449.1 - 0.015 14.4 0.2 0.079 12.0 0.0 1.9 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 3 N-terminus OmpH PF03938.14 KPI87449.1 - 0.026 14.9 0.7 1.9 8.8 0.3 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Lant_dehydr_C PF14028.6 KPI87449.1 - 0.038 13.5 0.5 0.15 11.6 0.1 1.9 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term End3 PF12761.7 KPI87449.1 - 0.057 13.6 1.9 0.087 13.0 0.4 1.8 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Tho2 PF11262.8 KPI87449.1 - 0.077 12.2 0.2 6.2 5.9 0.2 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DASH_Duo1 PF08651.10 KPI87449.1 - 0.16 11.8 0.1 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 DASH complex subunit Duo1 APG17 PF04108.12 KPI87451.1 - 0.035 13.2 5.7 0.21 10.7 1.7 2.0 2 0 0 2 2 2 0 Autophagy protein Apg17 DASH_Dad2 PF08654.10 KPI87451.1 - 0.05 14.0 0.7 0.97 9.9 0.2 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 Fib_alpha PF08702.10 KPI87451.1 - 0.07 13.3 4.4 0.15 12.2 1.7 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 KPI87451.1 - 0.15 12.4 5.9 0.18 12.2 3.6 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 KPI87451.1 - 1.6 7.9 4.0 1.6 7.9 0.8 2.0 2 0 0 2 2 2 0 TMPIT-like protein YolD PF08863.10 KPI87452.1 - 0.18 11.9 0.2 0.35 11.0 0.2 1.4 1 0 0 1 1 1 0 YolD-like protein Apolipoprotein PF01442.18 KPI87453.1 - 0.0021 17.9 12.8 0.0025 17.7 12.8 1.0 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Phasin PF05597.11 KPI87453.1 - 0.016 15.2 8.3 0.016 15.2 8.3 1.7 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4618 PF15397.6 KPI87453.1 - 0.02 14.3 13.3 0.023 14.1 13.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DCB PF16213.5 KPI87453.1 - 0.054 13.1 6.4 0.037 13.7 5.0 1.4 1 1 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 Hema_stalk PF08720.10 KPI87453.1 - 0.14 11.8 1.0 0.16 11.6 1.0 1.2 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk ApoO PF09769.9 KPI87453.1 - 0.14 12.1 3.0 0.35 10.8 3.0 1.7 1 1 0 1 1 1 0 Apolipoprotein O NAM-associated PF14303.6 KPI87453.1 - 0.17 12.6 15.4 0.21 12.3 15.4 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain HU-DNA_bdg PF14848.6 KPI87453.1 - 0.33 11.0 4.3 0.25 11.4 1.8 1.8 1 1 1 2 2 2 0 DNA-binding domain DivIVA PF05103.13 KPI87453.1 - 0.4 10.8 15.3 0.52 10.4 15.3 1.2 1 0 0 1 1 1 0 DivIVA protein DUF3461 PF11944.8 KPI87453.1 - 0.64 10.1 9.0 0.79 9.9 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) DUF883 PF05957.13 KPI87453.1 - 0.85 10.3 12.9 3.4 8.3 12.8 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) ATP-synt_B PF00430.18 KPI87453.1 - 0.9 9.6 21.3 1.2 9.3 18.7 1.8 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) PIN_2 PF10130.9 KPI87453.1 - 1.3 9.3 6.3 1.4 9.1 6.3 1.1 1 0 0 1 1 1 0 PIN domain BshC PF10079.9 KPI87453.1 - 1.4 7.6 11.9 1.4 7.5 11.9 1.0 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Borrelia_P83 PF05262.11 KPI87453.1 - 1.4 7.3 16.6 1.6 7.2 16.6 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein ZYG-11_interact PF05884.12 KPI87453.1 - 2.1 7.7 4.6 2.5 7.4 4.6 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 OmpH PF03938.14 KPI87453.1 - 2.1 8.7 18.6 3.2 8.1 18.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PRKCSH-like PF12999.7 KPI87453.1 - 2.3 8.0 7.0 3 7.6 7.0 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like FUSC-like PF12805.7 KPI87453.1 - 2.9 6.9 5.6 3.5 6.6 5.6 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS MCU PF04678.13 KPI87453.1 - 4 7.5 9.6 4.8 7.2 9.6 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter HSP70 PF00012.20 KPI87453.1 - 4.8 5.2 16.0 5.2 5.1 16.0 1.0 1 0 0 1 1 1 0 Hsp70 protein YlqD PF11068.8 KPI87453.1 - 8.7 6.7 16.0 17 5.8 16.0 1.5 1 1 0 1 1 1 0 YlqD protein Ipi1_N PF12333.8 KPI87454.1 - 0.019 15.5 7.6 0.033 14.8 0.3 4.3 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation VIGSSK PF14773.6 KPI87454.1 - 0.037 14.1 0.2 0.22 11.7 0.2 2.4 1 0 0 1 1 1 0 Helicase-associated putative binding domain, C-terminal ABC2_membrane_3 PF12698.7 KPI87456.1 - 9.4e-59 199.2 66.5 1.9e-41 142.3 24.4 3.3 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 KPI87456.1 - 5.3e-52 176.0 0.0 1.4e-28 100.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KPI87456.1 - 2.7e-20 73.4 3.9 4.3e-07 30.0 0.0 4.9 5 0 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI87456.1 - 1.5e-06 27.9 0.0 0.041 13.3 0.0 3.7 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 KPI87456.1 - 3.4e-06 27.0 0.0 1.1 8.8 0.0 4.2 4 0 0 4 4 4 2 AAA ATPase domain RsgA_GTPase PF03193.16 KPI87456.1 - 4e-06 26.8 0.1 0.0078 16.1 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase DUF4162 PF13732.6 KPI87456.1 - 1.4e-05 25.7 0.1 0.0033 18.1 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 KPI87456.1 - 0.00013 22.6 0.8 0.03 14.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KPI87456.1 - 0.00043 20.0 0.6 0.083 12.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC2_membrane_2 PF12679.7 KPI87456.1 - 0.028 13.7 43.3 0.0083 15.4 17.1 3.4 2 1 0 2 2 2 0 ABC-2 family transporter protein Wzy_C PF04932.15 KPI87456.1 - 0.034 13.8 0.0 0.034 13.8 0.0 4.9 4 1 0 4 4 2 0 O-Antigen ligase MMR_HSR1 PF01926.23 KPI87456.1 - 0.037 14.1 0.0 7.1 6.8 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_27 PF13514.6 KPI87456.1 - 0.053 13.1 0.1 0.9 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KPI87456.1 - 0.087 12.1 0.1 31 3.7 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin ABC_membrane PF00664.23 KPI87457.1 - 1.3e-118 395.6 25.3 9.8e-66 222.2 11.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KPI87457.1 - 1.7e-62 210.0 0.0 6.3e-32 110.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KPI87457.1 - 3.2e-11 43.1 0.9 2.7e-05 23.7 0.1 3.6 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KPI87457.1 - 4.4e-07 30.4 0.8 0.0037 17.7 0.2 2.9 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 KPI87457.1 - 4.9e-05 23.3 0.0 0.44 10.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KPI87457.1 - 7.1e-05 22.5 0.1 0.48 10.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 KPI87457.1 - 7.4e-05 22.4 0.1 0.008 15.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 KPI87457.1 - 0.00019 21.9 0.4 1.1 9.7 0.5 4.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.25 KPI87457.1 - 0.00025 20.7 0.1 0.11 12.1 0.0 2.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ABC_ATPase PF09818.9 KPI87457.1 - 0.00054 18.9 0.1 0.12 11.2 0.1 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 KPI87457.1 - 0.0017 17.6 0.1 0.4 9.9 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_15 PF13175.6 KPI87457.1 - 0.0021 17.8 0.0 2.4 7.8 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain G-alpha PF00503.20 KPI87457.1 - 0.0047 16.2 0.0 2.5 7.2 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_23 PF13476.6 KPI87457.1 - 0.0087 16.6 0.5 0.93 10.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 KPI87457.1 - 0.0098 16.1 4.1 6.8 7.0 0.3 4.1 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 KPI87457.1 - 0.01 15.8 0.0 8.1 6.4 0.0 3.5 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KPI87457.1 - 0.013 15.0 0.0 1.6 8.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Rad17 PF03215.15 KPI87457.1 - 0.014 15.3 0.0 4.6 7.1 0.0 3.2 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_22 PF13401.6 KPI87457.1 - 0.018 15.3 3.0 5.1 7.4 0.2 3.9 2 2 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KPI87457.1 - 0.025 14.8 0.0 1.2 9.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 KPI87457.1 - 0.032 14.0 0.0 1.7 8.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Viral_helicase1 PF01443.18 KPI87457.1 - 0.12 12.1 0.0 18 5.0 0.0 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 KPI87457.1 - 0.14 12.6 0.0 26 5.3 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 KPI87457.1 - 0.17 12.4 0.0 18 5.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 KPI87458.1 - 9.6e-30 103.8 0.0 1.3e-29 103.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87458.1 - 5.9e-13 48.7 0.0 8.9e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87458.1 - 0.00013 21.4 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI87458.1 - 0.034 14.1 0.3 6.8 6.5 0.0 3.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pex16 PF08610.10 KPI87463.1 - 2.6e-16 59.7 0.0 1.8e-13 50.4 0.0 2.5 2 1 0 2 2 2 2 Peroxisomal membrane protein (Pex16) DPM2 PF07297.12 KPI87464.1 - 1.8e-16 60.2 0.3 2.4e-16 59.8 0.3 1.2 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GDI PF00996.18 KPI87465.1 - 8.2e-18 64.1 0.0 1.8e-07 30.0 0.0 3.0 2 1 0 2 2 2 2 GDP dissociation inhibitor Methyltransf_16 PF10294.9 KPI87465.1 - 7.5e-11 42.1 0.0 7.4e-05 22.5 0.0 2.5 1 1 0 2 2 2 2 Lysine methyltransferase PrmA PF06325.13 KPI87465.1 - 0.076 12.4 0.2 0.14 11.5 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Nuc_sug_transp PF04142.15 KPI87467.1 - 5.7e-32 111.1 22.4 5.7e-30 104.6 22.4 2.8 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KPI87467.1 - 9e-06 25.9 32.1 6.9e-05 23.0 0.8 3.9 3 1 0 3 3 3 2 EamA-like transporter family MFS_1 PF07690.16 KPI87469.1 - 1.9e-12 46.8 33.7 3.7e-09 36.0 8.6 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily ArAE_1 PF06081.11 KPI87469.1 - 0.53 10.4 12.1 0.51 10.5 0.3 3.6 3 1 0 4 4 4 0 Aromatic acid exporter family member 1 Peptidase_S64 PF08192.11 KPI87470.1 - 0.92 7.9 7.0 1 7.8 7.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 KPI87470.1 - 4.6 6.0 10.0 6.2 5.6 10.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain MFS_1 PF07690.16 KPI87471.1 - 3.2e-12 46.0 43.0 3.6e-09 36.0 13.8 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KPI87471.1 - 0.00023 20.2 10.6 0.00023 20.2 10.6 3.3 2 2 2 4 4 4 3 Sugar (and other) transporter LRR_4 PF12799.7 KPI87472.1 - 3.5e-11 43.1 0.0 0.0071 16.7 0.1 5.4 3 1 4 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87472.1 - 2.3e-10 40.1 0.0 0.00013 21.7 0.0 4.5 4 2 0 4 4 4 3 Leucine rich repeat LRRNT_2 PF08263.12 KPI87472.1 - 8.5e-05 22.8 1.9 0.00011 22.4 0.1 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 KPI87473.1 - 5e-25 87.0 8.9 1.8e-05 24.4 0.3 6.8 3 2 7 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 KPI87473.1 - 1.2e-20 73.3 8.6 0.00036 20.9 0.3 8.5 3 2 10 13 13 13 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI87473.1 - 0.00014 21.6 11.8 19 5.6 0.1 9.1 10 0 0 10 10 10 1 Leucine Rich repeat LRR_1 PF00560.33 KPI87473.1 - 0.00061 20.0 1.7 1.9e+02 3.3 0.1 7.5 9 1 0 9 9 9 0 Leucine Rich Repeat LRRNT_2 PF08263.12 KPI87473.1 - 0.0017 18.6 0.6 0.0017 18.6 0.6 2.6 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain Inositol_P PF00459.25 KPI87474.1 - 1.4e-51 175.6 3.1 3.2e-25 89.2 0.3 2.5 2 1 0 2 2 2 2 Inositol monophosphatase family FAM53 PF15242.6 KPI87474.1 - 0.96 9.2 3.5 0.63 9.8 0.1 2.0 2 0 0 2 2 2 0 Family of FAM53 Chorein_N PF12624.7 KPI87475.1 - 1.2e-28 99.6 0.1 3e-28 98.3 0.1 1.7 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KPI87475.1 - 1.1e-27 97.4 0.1 7.3e-26 91.4 0.0 3.3 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 KPI87475.1 - 4.9e-11 42.5 0.0 2.8e-09 36.8 0.0 3.3 1 1 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 GP41 PF00517.17 KPI87477.1 - 0.13 12.1 2.1 0.25 11.2 1.6 1.7 1 1 0 1 1 1 0 Retroviral envelope protein V_ATPase_I PF01496.19 KPI87477.1 - 0.57 8.0 5.5 0.61 7.9 5.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nup192 PF11894.8 KPI87478.1 - 2.8e-07 28.1 4.3 0.0013 16.0 0.1 3.4 3 0 0 3 3 3 3 Nuclear pore complex scaffold, nucleoporins 186/192/205 Nup188 PF10487.9 KPI87478.1 - 0.0075 14.2 0.0 0.014 13.4 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 Syntaxin PF00804.25 KPI87479.1 - 0.025 14.3 0.2 0.041 13.5 0.2 1.3 1 0 0 1 1 1 0 Syntaxin BAG6 PF12057.8 KPI87479.1 - 0.081 12.6 0.8 6.4 6.5 0.1 2.5 2 0 0 2 2 2 0 BCL2-associated athanogene 6 Filament PF00038.21 KPI87479.1 - 0.098 12.2 0.5 0.15 11.6 0.5 1.3 1 0 0 1 1 1 0 Intermediate filament protein Com_YlbF PF06133.11 KPI87479.1 - 0.1 13.2 0.5 2.5 8.8 0.2 2.5 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA SKA2 PF16740.5 KPI87479.1 - 0.14 11.9 2.3 4 7.3 0.1 2.4 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 HOIP-UBA PF16678.5 KPI87479.1 - 0.29 11.1 1.7 3.2 7.7 0.4 2.8 2 1 0 2 2 2 0 HOIP UBA domain pair Sfi1 PF08457.10 KPI87480.1 - 1.8 7.0 71.7 0.029 12.9 12.7 5.6 2 1 4 6 6 6 0 Sfi1 spindle body protein BCS1_N PF08740.11 KPI87481.1 - 2e-29 102.9 1.0 1.1e-28 100.5 0.4 2.0 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 KPI87481.1 - 9.1e-20 71.4 0.0 1.7e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KPI87481.1 - 0.0012 18.6 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI87481.1 - 0.0023 18.4 0.2 0.021 15.2 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 KPI87481.1 - 0.0057 16.6 0.0 0.031 14.2 0.0 2.0 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_5 PF07728.14 KPI87481.1 - 0.0072 16.3 0.1 0.044 13.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 KPI87481.1 - 0.0077 15.4 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 KPI87481.1 - 0.0091 15.8 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KPI87481.1 - 0.014 15.8 0.0 0.045 14.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 KPI87481.1 - 0.022 15.3 0.0 0.047 14.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 KPI87481.1 - 0.039 14.1 0.1 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KPI87481.1 - 0.087 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KPI87481.1 - 0.13 12.8 0.0 0.4 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Lir1 PF07207.11 KPI87482.1 - 0.37 11.0 7.9 0.42 10.8 3.2 2.9 2 1 0 2 2 2 0 Light regulated protein Lir1 RestrictionSfiI PF11487.8 KPI87483.1 - 0.33 10.8 2.6 9.4 6.0 0.1 2.7 3 0 0 3 3 3 0 Type II restriction enzyme SfiI UPF0242 PF06785.11 KPI87483.1 - 5.8 7.0 7.6 4.1 7.5 0.4 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus OsmC PF02566.19 KPI87484.1 - 1.3e-06 28.8 1.0 2.4e-06 28.0 0.5 1.7 1 1 0 1 1 1 1 OsmC-like protein LRR_6 PF13516.6 KPI87485.1 - 0.0038 17.2 0.6 43 4.5 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich repeat Laminin_G_1 PF00054.23 KPI87485.1 - 0.031 14.5 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain Pectate_lyase PF03211.13 KPI87485.1 - 0.034 13.7 0.5 0.09 12.3 0.1 1.8 2 1 0 2 2 2 0 Pectate lyase Laminin_G_2 PF02210.24 KPI87485.1 - 0.059 13.9 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain Calpain_inhib PF00748.19 KPI87485.1 - 7.9 7.0 7.2 0.71 10.4 0.3 2.6 3 0 0 3 3 3 0 Calpain inhibitor Piezo_RRas_bdg PF12166.8 KPI87487.1 - 2e-86 291.0 0.0 2.8e-86 290.4 0.0 1.2 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain Creb_binding PF09030.10 KPI87487.1 - 0.46 11.2 5.5 0.1 13.3 0.7 2.4 2 0 0 2 2 2 0 Creb binding DNA_pol_A PF00476.20 KPI87488.1 - 1.7e-94 317.0 0.0 9.7e-84 281.6 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase family A NIF PF03031.18 KPI87489.1 - 6.4e-30 104.0 0.1 1.7e-27 96.1 0.0 3.0 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase TPR_MLP1_2 PF07926.12 KPI87490.1 - 0.024 14.7 10.0 0.037 14.1 10.0 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 KPI87490.1 - 0.028 14.5 3.6 0.17 12.0 0.2 2.7 1 1 1 3 3 3 0 TolA binding protein trimerisation Herpes_U30 PF04523.13 KPI87490.1 - 0.03 12.2 2.8 0.034 12.0 2.8 1.0 1 0 0 1 1 1 0 Herpes virus tegument protein U30 AIP3 PF03915.13 KPI87490.1 - 0.031 13.4 6.7 0.037 13.1 6.7 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 SKA1 PF07160.12 KPI87490.1 - 0.04 13.8 4.3 0.2 11.5 4.2 1.8 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DASH_Duo1 PF08651.10 KPI87490.1 - 0.046 13.5 1.2 0.68 9.7 0.1 2.7 3 0 0 3 3 3 0 DASH complex subunit Duo1 Ribosomal_L22 PF00237.19 KPI87490.1 - 0.068 13.4 0.6 0.13 12.5 0.6 1.6 1 1 0 1 1 1 0 Ribosomal protein L22p/L17e Sec34 PF04136.15 KPI87490.1 - 0.09 12.7 5.7 0.082 12.8 2.3 2.0 1 1 1 2 2 2 0 Sec34-like family Mce4_CUP1 PF11887.8 KPI87490.1 - 0.1 12.1 1.9 0.13 11.7 1.4 1.4 1 1 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative TINF2_N PF14973.6 KPI87490.1 - 0.1 12.9 2.8 0.27 11.6 0.2 2.1 1 1 1 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus Prominin PF05478.11 KPI87490.1 - 0.11 10.5 4.0 0.14 10.1 4.0 1.1 1 0 0 1 1 1 0 Prominin DUF948 PF06103.11 KPI87490.1 - 0.11 12.7 1.7 0.38 11.0 1.6 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF3533 PF12051.8 KPI87490.1 - 0.21 10.5 0.3 2.3 7.0 0.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3533) Serine_rich PF08824.10 KPI87490.1 - 0.22 11.5 5.9 0.83 9.6 5.9 1.8 1 1 0 1 1 1 0 Serine rich protein interaction domain Fib_alpha PF08702.10 KPI87490.1 - 0.25 11.5 4.9 0.84 9.8 4.6 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 KPI87490.1 - 0.26 11.1 3.6 5.6 6.7 0.5 2.1 1 1 0 2 2 2 0 Phage minor structural protein GP20 GAS PF13851.6 KPI87490.1 - 0.48 9.7 8.1 1.9 7.8 8.1 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Corona_S2 PF01601.16 KPI87490.1 - 0.58 8.6 2.5 0.71 8.3 2.5 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein COG2 PF06148.11 KPI87490.1 - 0.74 9.9 8.2 0.51 10.4 0.3 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.12 KPI87490.1 - 1.4 8.9 3.9 7.7 6.5 0.3 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Plasmid_RAQPRD PF09686.10 KPI87490.1 - 1.8 8.8 6.4 3.4 8.0 0.1 2.8 2 1 1 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) BST2 PF16716.5 KPI87490.1 - 6 7.5 9.5 5.4 7.7 3.0 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 APG6_N PF17675.1 KPI87490.1 - 9.5 6.8 9.9 54 4.3 9.9 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region DNA_pol_A_exo1 PF01612.20 KPI87491.1 - 1.6e-14 54.0 0.0 1.1e-13 51.3 0.0 2.1 2 0 0 2 2 2 1 3'-5' exonuclease LZ3wCH PF18517.1 KPI87491.1 - 0.018 15.1 0.2 0.064 13.4 0.2 2.0 1 0 0 1 1 1 0 Leucine zipper with capping helix domain CooC_C PF15976.5 KPI87491.1 - 0.077 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 CS1-pili formation C-terminal DUF2046 PF09755.9 KPI87492.1 - 0.0003 20.1 3.0 0.00059 19.2 3.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) DUF1515 PF07439.11 KPI87492.1 - 0.031 14.3 0.5 0.031 14.3 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) YabA PF06156.13 KPI87492.1 - 0.042 14.5 4.1 0.1 13.3 1.2 2.7 2 0 0 2 2 2 0 Initiation control protein YabA TubC_N PF18563.1 KPI87492.1 - 0.18 11.8 0.2 0.98 9.5 0.1 2.4 2 0 0 2 2 2 0 TubC N-terminal docking domain Shugoshin_N PF07558.11 KPI87492.1 - 0.4 10.6 1.7 0.9 9.5 0.4 2.1 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 KPI87492.1 - 0.94 9.3 9.3 6.2 6.7 0.5 3.6 1 1 2 3 3 3 0 Septum formation initiator bZIP_1 PF00170.21 KPI87492.1 - 1.2 9.3 6.6 1.5 9.0 0.6 3.3 2 1 1 3 3 3 0 bZIP transcription factor Exo_endo_phos PF03372.23 KPI87493.1 - 5.3e-05 22.8 0.0 0.00019 21.1 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Arc PF03869.14 KPI87495.1 - 0.59 10.0 2.8 2.9 7.8 0.1 2.6 2 0 0 2 2 2 0 Arc-like DNA binding domain tRNA_lig_CPD PF08302.11 KPI87497.1 - 8.6e-07 28.7 0.0 5e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 KPI87497.1 - 0.0055 16.8 0.0 0.071 13.2 0.0 2.2 1 1 0 1 1 1 1 tRNA ligase kinase domain ABC_tran PF00005.27 KPI87497.1 - 0.0084 16.6 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 KPI87497.1 - 0.013 15.8 0.0 0.048 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 KPI87497.1 - 0.023 14.9 0.0 0.059 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 KPI87497.1 - 0.026 14.3 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain PRK PF00485.18 KPI87497.1 - 0.049 13.4 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATP_bind_1 PF03029.17 KPI87497.1 - 0.08 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 KPI87497.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 KPI87497.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KPI87497.1 - 0.14 12.4 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KPI87497.1 - 0.18 11.6 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Macoilin PF09726.9 KPI87500.1 - 7.3 5.0 18.3 10 4.5 18.3 1.2 1 0 0 1 1 1 0 Macoilin family CorA PF01544.18 KPI87503.1 - 0.016 14.5 0.0 0.035 13.4 0.0 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein CRAL_TRIO PF00650.20 KPI87504.1 - 8.4e-31 106.8 0.0 1.5e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KPI87504.1 - 0.017 15.3 0.1 0.049 13.8 0.1 1.8 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain LMSTEN PF07988.12 KPI87504.1 - 0.065 12.7 0.1 0.14 11.6 0.1 1.5 1 0 0 1 1 1 0 LMSTEN motif Rhabdo_matrix PF03397.14 KPI87504.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus matrix protein CRAL_TRIO PF00650.20 KPI87505.1 - 4.5e-24 85.0 0.0 7e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 KPI87505.1 - 0.005 17.3 0.2 2.1 8.8 0.1 2.5 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO PF00650.20 KPI87506.1 - 2.3e-32 111.9 0.0 3.9e-32 111.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KPI87506.1 - 0.15 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Med3 PF11593.8 KPI87508.1 - 0.002 17.4 1.9 0.0029 16.9 1.9 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal DFRP_C PF16543.5 KPI87509.1 - 0.059 13.9 0.2 0.34 11.4 0.0 2.0 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Peptidase_M8 PF01457.16 KPI87511.1 - 8.7e-125 417.4 1.0 7.1e-124 414.4 1.0 1.9 1 1 0 1 1 1 1 Leishmanolysin Helicase_C PF00271.31 KPI87513.1 - 2.7e-07 30.9 1.1 4.7e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 KPI87513.1 - 0.016 15.5 0.1 0.016 15.5 0.1 2.0 2 0 0 2 2 2 0 Helicase associated domain (HA2) zf-C2H2_jaz PF12171.8 KPI87513.1 - 1.8 9.0 5.8 4.5 7.7 5.8 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding SET PF00856.28 KPI87514.1 - 1.6e-08 35.1 0.0 4e-07 30.6 0.0 2.5 1 1 0 1 1 1 1 SET domain Orn_Arg_deC_N PF02784.16 KPI87515.1 - 2.9e-80 269.2 0.0 3.9e-80 268.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KPI87515.1 - 3.8e-11 43.1 0.0 2.2e-10 40.6 0.0 2.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 KPI87515.1 - 0.00016 21.2 0.0 0.00098 18.6 0.0 2.1 2 1 1 3 3 3 1 Xylose isomerase-like TIM barrel DUF4519 PF15012.6 KPI87516.1 - 8.9 6.6 6.6 2.5 8.3 1.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) SAC3_GANP PF03399.16 KPI87517.1 - 6.9e-16 58.5 0.6 1.4e-14 54.2 0.6 2.6 1 1 0 1 1 1 1 SAC3/GANP family DUF2561 PF10812.8 KPI87518.1 - 0.58 10.2 0.0 0.58 10.2 0.0 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF2561) Myotub-related PF06602.14 KPI87519.1 - 1e-62 212.1 0.0 1.4e-34 119.6 0.0 2.6 3 0 0 3 3 3 2 Myotubularin-like phosphatase domain RRM_Rrp7 PF17799.1 KPI87521.1 - 0.88 9.4 4.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain NOT2_3_5 PF04153.18 KPI87522.1 - 4.8e-22 78.4 1.2 4.8e-22 78.4 1.2 2.2 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family GST_N_3 PF13417.6 KPI87523.1 - 1.5e-11 44.6 0.0 1.4e-10 41.4 0.0 2.2 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KPI87523.1 - 1.6e-10 41.1 0.0 5.2e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KPI87523.1 - 8.8e-08 32.3 0.0 2.3e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KPI87523.1 - 0.00019 21.5 0.0 0.00072 19.7 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KPI87523.1 - 0.00073 19.5 0.3 0.0013 18.7 0.3 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KPI87523.1 - 0.0078 16.4 0.8 0.03 14.5 0.0 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain PNPase PF03726.14 KPI87523.1 - 0.078 13.5 0.3 0.16 12.5 0.3 1.5 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain PUF PF00806.19 KPI87525.1 - 7.6e-31 104.1 7.4 0.00034 20.1 0.0 7.6 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat DapB_N PF01113.20 KPI87526.1 - 0.00028 21.0 0.2 0.0026 17.9 0.2 2.5 3 0 0 3 3 3 1 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 KPI87526.1 - 0.024 14.2 0.5 0.043 13.4 0.5 1.4 1 0 0 1 1 1 0 NmrA-like family KR PF08659.10 KPI87526.1 - 0.039 13.9 0.1 0.076 12.9 0.1 1.5 1 0 0 1 1 1 0 KR domain Epimerase PF01370.21 KPI87526.1 - 0.041 13.4 0.1 0.074 12.5 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KPI87526.1 - 0.092 12.6 2.3 0.099 12.5 0.4 2.1 2 1 0 2 2 2 0 NAD(P)H-binding NAD_binding_4 PF07993.12 KPI87526.1 - 0.13 11.4 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein Pkinase PF00069.25 KPI87527.1 - 3.4e-67 226.6 0.0 2.3e-39 135.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87527.1 - 8.7e-36 123.5 0.0 8.2e-25 87.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI87527.1 - 0.00041 19.8 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KPI87527.1 - 0.00061 19.2 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI87527.1 - 0.0052 15.8 0.0 0.0077 15.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KPI87527.1 - 0.0087 14.9 0.0 0.016 14.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI87527.1 - 0.054 13.4 4.9 0.2 11.5 4.8 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family RNA_pol_Rpc34 PF05158.12 KPI87528.1 - 8.8e-56 189.7 0.0 2.3e-55 188.3 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit TFIIE_alpha PF02002.17 KPI87528.1 - 0.0061 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit z-alpha PF02295.17 KPI87528.1 - 0.026 14.6 0.3 0.31 11.1 0.1 2.3 2 0 0 2 2 2 0 Adenosine deaminase z-alpha domain Rrf2 PF02082.20 KPI87528.1 - 0.59 10.5 3.3 6.6 7.2 0.2 2.6 3 0 0 3 3 3 0 Transcriptional regulator Carn_acyltransf PF00755.20 KPI87529.1 - 8.3e-119 397.8 0.0 1e-118 397.5 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase FtsK_SpoIIIE PF01580.18 KPI87530.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ubiq_cyt_C_chap PF03981.12 KPI87530.1 - 0.16 12.0 0.0 0.58 10.2 0.0 1.8 1 1 0 1 1 1 0 Ubiquinol-cytochrome C chaperone DSS1_SEM1 PF05160.13 KPI87531.1 - 0.2 11.7 13.6 0.65 10.1 13.7 1.9 1 1 0 1 1 1 0 DSS1/SEM1 family Lipase_3 PF01764.25 KPI87532.1 - 1.6e-24 86.3 0.0 3.6e-24 85.2 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) PHO4 PF01384.20 KPI87532.1 - 6.4 5.7 8.2 6.7 5.7 0.1 2.4 1 1 1 2 2 2 0 Phosphate transporter family Voltage_CLC PF00654.20 KPI87532.1 - 6.7 5.8 18.4 1.1 8.4 2.5 2.3 2 0 0 2 2 2 0 Voltage gated chloride channel AAA_2 PF07724.14 KPI87533.1 - 2.6e-57 193.6 0.3 1.4e-54 184.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KPI87533.1 - 1.9e-36 124.1 1.7 1.9e-36 124.1 1.7 2.7 2 0 0 2 2 2 1 AAA lid domain AAA PF00004.29 KPI87533.1 - 2.1e-28 99.4 0.1 5e-15 56.1 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KPI87533.1 - 1.5e-21 76.2 0.1 1.5e-21 76.2 0.1 3.5 4 0 0 4 4 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 KPI87533.1 - 3e-16 59.7 0.3 3.3e-11 43.4 0.0 3.6 2 2 1 3 3 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 KPI87533.1 - 4e-13 49.3 6.6 1.6e-05 25.0 0.0 3.9 3 0 0 3 3 3 2 Clp amino terminal domain, pathogenicity island component AAA_22 PF13401.6 KPI87533.1 - 5.3e-10 39.7 0.7 0.0075 16.5 0.0 4.9 3 2 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 KPI87533.1 - 1.1e-09 38.3 0.0 2.8e-06 27.1 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 KPI87533.1 - 3.7e-08 33.5 0.0 0.0052 16.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KPI87533.1 - 3.8e-08 33.3 0.0 0.012 15.3 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_16 PF13191.6 KPI87533.1 - 6.1e-08 33.2 13.4 0.0015 18.9 0.2 5.8 2 2 1 4 4 4 2 AAA ATPase domain TniB PF05621.11 KPI87533.1 - 2.9e-07 30.1 0.0 0.00019 20.9 0.0 3.5 2 1 0 2 2 2 1 Bacterial TniB protein RuvB_N PF05496.12 KPI87533.1 - 2.6e-06 27.2 2.1 0.4 10.4 0.0 4.4 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 KPI87533.1 - 4e-06 26.5 0.0 0.043 13.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 KPI87533.1 - 4.9e-06 26.6 0.0 0.12 12.3 0.0 4.0 3 0 0 3 3 3 2 NACHT domain Mg_chelatase PF01078.21 KPI87533.1 - 2.8e-05 23.6 0.0 0.19 11.1 0.0 3.4 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KPI87533.1 - 0.00024 21.7 0.0 0.16 12.5 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KPI87533.1 - 0.00036 21.1 17.8 0.097 13.2 0.0 4.0 2 1 1 3 3 2 2 AAA domain Zeta_toxin PF06414.12 KPI87533.1 - 0.00042 19.7 1.3 0.13 11.5 0.0 3.9 4 0 0 4 4 4 1 Zeta toxin DUF815 PF05673.13 KPI87533.1 - 0.00046 19.4 0.4 0.25 10.5 0.1 3.5 3 1 0 3 3 3 1 Protein of unknown function (DUF815) Roc PF08477.13 KPI87533.1 - 0.00051 20.3 0.0 1.6 9.0 0.0 3.0 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 KPI87533.1 - 0.00087 19.3 8.4 0.72 9.7 0.2 4.2 3 2 2 5 5 4 2 ATPase domain predominantly from Archaea ResIII PF04851.15 KPI87533.1 - 0.0016 18.5 0.0 0.2 11.6 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TsaE PF02367.17 KPI87533.1 - 0.0017 18.4 0.0 2 8.4 0.0 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KPI87533.1 - 0.0018 18.4 0.1 1.3 9.2 0.0 3.4 3 0 0 3 3 3 1 AAA domain DNA_pol3_delta2 PF13177.6 KPI87533.1 - 0.0019 18.0 0.0 0.56 10.0 0.0 3.1 3 0 0 3 3 3 1 DNA polymerase III, delta subunit RNA_helicase PF00910.22 KPI87533.1 - 0.002 18.5 0.0 3.1 8.2 0.0 3.1 2 0 0 2 2 2 1 RNA helicase TIP49 PF06068.13 KPI87533.1 - 0.0021 17.3 0.1 1 8.5 0.0 3.2 2 1 1 3 3 3 1 TIP49 P-loop domain Bac_DnaA PF00308.18 KPI87533.1 - 0.0043 16.9 1.0 2.7 7.8 0.0 3.2 3 1 0 3 3 3 1 Bacterial dnaA protein AAA_25 PF13481.6 KPI87533.1 - 0.0053 16.3 2.1 0.32 10.6 0.0 3.5 3 1 1 4 4 4 1 AAA domain AAA_3 PF07726.11 KPI87533.1 - 0.0056 16.5 0.1 2 8.3 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KPI87533.1 - 0.0057 16.6 0.1 5.2 7.0 0.0 3.4 3 1 1 4 4 3 0 RsgA GTPase ABC_tran PF00005.27 KPI87533.1 - 0.007 16.9 1.5 7 7.2 0.0 3.9 4 1 0 4 4 3 0 ABC transporter AAA_29 PF13555.6 KPI87533.1 - 0.014 15.2 0.0 8.2 6.3 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF4041 PF13250.6 KPI87533.1 - 0.028 14.3 1.2 0.089 12.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) AAA_28 PF13521.6 KPI87533.1 - 0.03 14.6 0.0 37 4.5 0.0 3.8 3 0 0 3 3 3 0 AAA domain Tetrabrachion PF11401.8 KPI87533.1 - 0.031 14.3 0.2 0.38 10.8 0.0 2.5 2 0 0 2 2 2 0 Tetrabrachion NTPase_1 PF03266.15 KPI87533.1 - 0.062 13.2 2.9 2.9 7.8 0.0 3.5 4 0 0 4 4 3 0 NTPase AAA_24 PF13479.6 KPI87533.1 - 0.069 12.9 0.1 9 6.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain Spc7 PF08317.11 KPI87533.1 - 0.076 11.9 11.7 0.19 10.6 11.7 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein SASA PF03629.18 KPI87533.1 - 0.094 12.3 0.5 0.19 11.4 0.5 1.5 1 0 0 1 1 1 0 Carbohydrate esterase, sialic acid-specific acetylesterase AAA_19 PF13245.6 KPI87533.1 - 0.68 10.3 7.5 0.47 10.8 0.2 4.0 4 2 0 5 5 4 0 AAA domain V_ATPase_I PF01496.19 KPI87533.1 - 1.2 7.0 3.9 1.9 6.3 3.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF87 PF01935.17 KPI87533.1 - 2.3 8.2 0.0 2.3 8.2 0.0 3.5 4 1 0 4 4 3 0 Helicase HerA, central domain DUF16 PF01519.16 KPI87533.1 - 5.4 7.6 12.7 2.3 8.7 3.5 3.4 2 1 1 3 3 2 0 Protein of unknown function DUF16 Lipase_3 PF01764.25 KPI87534.1 - 7.3e-26 90.7 0.0 1.8e-24 86.2 0.0 2.2 1 1 0 1 1 1 1 Lipase (class 3) MIG-14_Wnt-bd PF06664.12 KPI87534.1 - 4.5e-10 39.2 1.1 4.5e-10 39.2 1.1 2.6 2 1 1 3 3 3 1 Wnt-binding factor required for Wnt secretion HSP70 PF00012.20 KPI87536.1 - 7.5e-29 100.4 3.8 1.5e-26 92.8 0.0 2.5 1 1 1 2 2 2 1 Hsp70 protein TPR_2 PF07719.17 KPI87536.1 - 2.9e-11 42.6 0.3 7.1e-06 25.7 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87536.1 - 3.1e-10 39.4 0.1 9.9e-06 25.2 0.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87536.1 - 8.2e-08 32.4 0.4 8.4e-06 26.0 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI87536.1 - 1.5e-06 27.9 0.2 0.00045 20.2 0.0 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87536.1 - 4e-06 26.4 0.2 0.13 12.0 0.0 2.9 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.6 KPI87536.1 - 5.8e-06 26.4 0.7 0.00021 21.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87536.1 - 0.00016 21.5 1.3 0.28 11.3 0.1 3.4 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87536.1 - 0.00017 22.0 0.4 0.0029 18.1 0.2 2.9 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KPI87536.1 - 0.00046 20.8 0.0 0.0019 18.8 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87536.1 - 0.0017 19.0 3.6 0.0025 18.5 0.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI87536.1 - 0.0085 16.3 0.2 0.0085 16.3 0.2 2.4 2 1 1 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF1216 PF06746.11 KPI87536.1 - 0.011 15.7 0.5 0.011 15.7 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) TPR_17 PF13431.6 KPI87536.1 - 0.016 15.6 0.0 0.066 13.6 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC5 PF12862.7 KPI87536.1 - 0.017 15.2 0.1 0.23 11.5 0.1 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 5 TPR_6 PF13174.6 KPI87536.1 - 0.025 15.2 0.5 0.33 11.7 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FtsA PF14450.6 KPI87536.1 - 0.15 12.5 0.2 33 5.0 0.0 3.3 3 0 0 3 3 3 0 Cell division protein FtsA CCDC-167 PF15188.6 KPI87536.1 - 1.3 9.5 7.4 2.8 8.3 5.8 2.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 HemY_N PF07219.13 KPI87536.1 - 8.5 6.6 9.6 1.3 9.2 0.8 3.3 3 0 0 3 3 3 0 HemY protein N-terminus Sec16_C PF12931.7 KPI87537.1 - 1e-10 41.8 0.0 1.8e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 DUF572 PF04502.13 KPI87538.1 - 2.4e-16 60.3 16.3 1e-15 58.2 16.2 1.8 1 1 0 1 1 1 1 Family of unknown function (DUF572) zf-AN1 PF01428.16 KPI87538.1 - 0.3 11.3 1.7 0.45 10.7 0.2 1.9 2 0 0 2 2 2 0 AN1-like Zinc finger DUF4230 PF14014.6 KPI87538.1 - 0.61 10.4 0.1 0.61 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) DUF4407 PF14362.6 KPI87538.1 - 3.8 6.8 6.3 1.8 7.8 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Peptidase_M60_C PF18630.1 KPI87539.1 - 0.13 12.4 0.7 22 5.3 0.0 3.2 3 0 0 3 3 3 0 Peptidase M60 C-terminal domain Thioredoxin_8 PF13905.6 KPI87542.1 - 8.4e-05 22.8 0.0 0.24 11.8 0.0 3.5 3 0 0 3 3 3 2 Thioredoxin-like EF-hand_7 PF13499.6 KPI87543.1 - 0.00015 22.2 0.0 0.00065 20.1 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KPI87543.1 - 0.00038 20.2 0.1 0.0014 18.4 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KPI87543.1 - 0.0028 17.1 0.1 0.024 14.2 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 KPI87543.1 - 0.013 15.8 0.0 0.034 14.5 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_6 PF13405.6 KPI87543.1 - 0.036 14.0 0.0 0.1 12.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain Thioredoxin_8 PF13905.6 KPI87544.1 - 6.9e-25 87.2 0.0 9.1e-25 86.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KPI87544.1 - 1.4e-10 41.2 0.0 2.4e-10 40.4 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KPI87544.1 - 3e-09 36.7 0.0 3.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 KPI87544.1 - 6.8e-09 35.7 0.2 7.7e-06 25.8 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 KPI87544.1 - 1.9e-06 28.2 0.0 2.9e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 KPI87544.1 - 1.1e-05 25.4 0.0 4.6e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 KPI87544.1 - 0.0034 17.1 0.0 0.077 12.8 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin DUF953 PF06110.11 KPI87544.1 - 0.017 14.8 0.1 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_7 PF13899.6 KPI87544.1 - 0.031 14.4 0.1 0.091 12.9 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin-like SCO1-SenC PF02630.14 KPI87544.1 - 0.058 13.3 0.0 0.081 12.8 0.0 1.4 1 1 0 1 1 1 0 SCO1/SenC Thioredoxin_5 PF13743.6 KPI87544.1 - 0.09 12.4 0.8 0.83 9.3 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_8 PF13905.6 KPI87545.1 - 8.1e-24 83.8 0.0 1.1e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KPI87545.1 - 5.4e-08 32.8 0.0 8e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KPI87545.1 - 6.7e-07 29.1 0.0 6.9e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 KPI87545.1 - 1.6e-06 28.1 0.1 2.3e-05 24.3 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 KPI87545.1 - 0.00011 22.6 0.0 0.00017 22.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 KPI87545.1 - 0.00032 20.6 0.0 0.00095 19.0 0.0 1.7 1 1 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KPI87545.1 - 0.0012 19.0 0.0 0.0019 18.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KPI87545.1 - 0.049 13.4 0.0 0.44 10.3 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.6 KPI87546.1 - 4.2e-21 75.1 0.0 1.4e-16 60.6 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 KPI87546.1 - 2.5e-10 40.3 0.0 4.8e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KPI87546.1 - 4.5e-10 39.5 0.0 8.6e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 KPI87546.1 - 2.5e-08 33.8 0.0 1e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 KPI87546.1 - 0.00019 21.5 0.0 0.00038 20.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 KPI87546.1 - 0.00027 20.9 0.2 0.00047 20.0 0.0 1.4 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 KPI87546.1 - 0.00031 21.2 0.1 0.00095 19.6 0.1 1.7 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KPI87546.1 - 0.0075 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Hex_IIIa PF02455.16 KPI87546.1 - 0.077 11.8 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Thioredoxin_8 PF13905.6 KPI87547.1 - 4.7e-08 33.2 0.0 1e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like G6PD_N PF00479.22 KPI87547.1 - 0.18 12.4 0.0 0.27 11.8 0.0 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain Methyltransf_16 PF10294.9 KPI87548.1 - 1.6e-07 31.2 0.6 2.5e-06 27.3 0.6 2.2 1 1 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 KPI87548.1 - 0.038 13.7 0.0 0.062 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Phage_holin_5_1 PF06946.11 KPI87548.1 - 0.077 13.4 0.4 7.4 7.0 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 Methyltransf_25 PF13649.6 KPI87548.1 - 0.13 13.0 0.1 0.82 10.4 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain Abhydrolase_1 PF00561.20 KPI87550.1 - 4e-06 26.7 0.1 0.0029 17.3 0.0 2.6 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 KPI87550.1 - 0.017 14.7 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S9 PF00326.21 KPI87550.1 - 0.023 14.2 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KPI87550.1 - 0.028 13.7 0.0 7.2 5.8 0.0 2.2 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Vps39_2 PF10367.9 KPI87551.1 - 5.2e-25 88.0 0.1 1.4e-24 86.7 0.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 KPI87551.1 - 4.4e-05 23.7 0.0 0.0013 19.0 0.0 2.6 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 KPI87551.1 - 0.0014 18.5 0.0 2.3 8.1 0.0 3.2 2 1 1 3 3 3 2 Region in Clathrin and VPS Rad50_zn_hook PF04423.14 KPI87551.1 - 0.019 14.8 0.2 0.041 13.7 0.2 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif PQQ_3 PF13570.6 KPI87551.1 - 0.026 15.0 0.0 0.082 13.4 0.0 1.9 1 0 0 1 1 1 0 PQQ-like domain FAM91_C PF14648.6 KPI87552.1 - 1.8e-111 373.1 0.0 2.3e-111 372.7 0.0 1.1 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.6 KPI87552.1 - 1.1e-100 336.9 0.1 1.5e-100 336.5 0.1 1.2 1 0 0 1 1 1 1 FAM91 N-terminus RNase_H2_suC PF08615.11 KPI87553.1 - 1.9e-08 34.6 0.0 4.8e-08 33.3 0.0 1.6 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SET PF00856.28 KPI87554.1 - 2.6e-09 37.7 0.2 5.5e-09 36.6 0.2 1.6 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 KPI87554.1 - 2.6e-05 24.2 4.3 2.6e-05 24.2 4.3 2.9 3 0 0 3 3 3 1 MYND finger TPR_12 PF13424.6 KPI87554.1 - 0.0045 17.3 0.6 0.084 13.2 0.1 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87554.1 - 0.017 15.0 0.0 2.5 8.1 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87554.1 - 0.037 14.1 0.0 8 6.9 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CCDC23 PF15674.5 KPI87556.1 - 0.21 11.6 0.4 0.48 10.5 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 23 Methyltransf_31 PF13847.6 KPI87557.1 - 1e-12 48.1 0.5 3e-12 46.6 0.4 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI87557.1 - 1.3e-12 48.2 0.1 4.4e-12 46.5 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 KPI87557.1 - 4.1e-12 46.1 0.0 1.1e-11 44.7 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 KPI87557.1 - 5e-09 36.7 0.1 1.4e-08 35.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI87557.1 - 6e-07 29.4 0.0 8.8e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI87557.1 - 1.9e-06 27.5 0.1 1.9e-06 27.5 0.1 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 KPI87557.1 - 3.5e-06 27.7 0.1 1.1e-05 26.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 KPI87557.1 - 2.4e-05 23.4 0.0 3.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 KPI87557.1 - 0.00019 20.8 0.2 0.00032 20.1 0.2 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 KPI87557.1 - 0.00023 21.1 0.1 0.00043 20.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 KPI87557.1 - 0.00033 20.1 1.2 0.00062 19.2 0.3 1.9 2 1 0 2 2 2 1 Tellurite resistance protein TehB PRMT5 PF05185.16 KPI87557.1 - 0.00036 20.4 0.0 0.00059 19.7 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase FtsJ PF01728.19 KPI87557.1 - 0.0096 16.0 0.0 0.014 15.6 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 KPI87557.1 - 0.011 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 KPI87557.1 - 0.033 15.2 0.0 0.077 14.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KPI87557.1 - 0.037 13.8 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 KPI87557.1 - 0.045 13.5 0.0 0.07 12.9 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein zf-RING_10 PF16685.5 KPI87558.1 - 0.11 12.7 0.9 0.22 11.7 0.9 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RanBP PF00641.18 KPI87558.1 - 0.17 11.2 1.9 0.39 10.1 1.9 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zinc_ribbon_2 PF13240.6 KPI87558.1 - 0.57 10.0 2.9 1 9.1 2.9 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Peptidase_M1 PF01433.20 KPI87559.1 - 2.7e-51 174.2 0.3 4.4e-51 173.5 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KPI87559.1 - 3.4e-23 82.8 0.0 3.1e-17 63.4 0.0 2.3 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 KPI87559.1 - 3.3e-05 23.6 0.0 7.4e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 ERAP1-like C-terminal domain Myotoxins PF00819.17 KPI87559.1 - 1.6 9.0 3.8 0.7 10.2 0.0 2.2 2 0 0 2 2 2 0 Myotoxin, crotamine zf-RING_UBOX PF13445.6 KPI87560.1 - 6.7e-08 32.4 2.8 1.9e-07 31.0 2.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KPI87560.1 - 2.3e-05 24.1 7.7 7.3e-05 22.5 7.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI87560.1 - 8.7e-05 22.3 3.1 8.7e-05 22.3 3.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI87560.1 - 0.00013 22.0 3.9 0.00013 22.0 3.9 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KPI87560.1 - 0.059 13.3 8.2 0.03 14.3 4.9 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KPI87560.1 - 0.092 12.6 15.4 0.029 14.2 11.6 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI87560.1 - 0.5 10.3 10.1 0.096 12.6 6.1 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KPI87560.1 - 0.72 10.2 15.5 0.11 12.9 10.5 2.2 2 0 0 2 2 2 0 Ring finger domain zf-RING_6 PF14835.6 KPI87560.1 - 1.2 9.0 8.2 3.1 7.7 8.2 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein SNARE_assoc PF09335.11 KPI87561.1 - 2.4e-20 73.2 6.8 2.4e-20 73.2 6.8 2.5 3 0 0 3 3 3 1 SNARE associated Golgi protein FtsK_4TM PF13491.6 KPI87561.1 - 0.0095 15.7 4.1 0.023 14.4 4.1 1.7 1 0 0 1 1 1 1 4TM region of DNA translocase FtsK/SpoIIIE Mcl1_mid PF12341.8 KPI87563.1 - 1.1e-55 189.1 0.0 1.6e-55 188.6 0.0 1.2 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 KPI87563.1 - 0.13 13.2 2.4 32 5.6 0.1 4.5 4 0 0 4 4 4 0 WD domain, G-beta repeat NUDE_C PF04880.13 KPI87564.1 - 0.00077 20.0 4.3 0.00077 20.0 4.3 6.7 5 2 1 6 6 6 1 NUDE protein, C-terminal conserved region ABC_tran PF00005.27 KPI87566.1 - 1.1e-10 42.2 0.0 4.6e-05 23.9 0.0 2.8 3 0 0 3 3 3 2 ABC transporter AAA_16 PF13191.6 KPI87566.1 - 0.022 15.1 0.1 0.12 12.7 0.1 2.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 KPI87566.1 - 0.026 15.0 0.0 0.047 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KPI87566.1 - 0.13 12.5 0.1 0.41 10.9 0.1 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KPI87567.1 - 4.7e-09 36.9 0.0 0.00061 20.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter CSD PF00313.22 KPI87568.1 - 0.0079 16.0 0.0 0.086 12.7 0.0 2.4 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KPI87568.1 - 0.044 13.5 1.3 0.067 12.9 0.1 1.9 2 0 0 2 2 2 0 Ribonuclease B OB domain HOOK PF05622.12 KPI87569.1 - 0.058 11.5 0.1 0.075 11.2 0.1 1.1 1 0 0 1 1 1 0 HOOK protein TBCA PF02970.16 KPI87570.1 - 0.024 14.9 0.5 0.07 13.5 0.5 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor A DUF4355 PF14265.6 KPI87570.1 - 1.1 9.5 4.7 0.24 11.6 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) RFXA_RFXANK_bdg PF15289.6 KPI87573.1 - 0.4 11.0 5.8 0.37 11.1 1.3 2.3 2 1 1 3 3 3 0 Regulatory factor X-associated C-terminal binding domain GATase PF00117.28 KPI87575.1 - 8.2e-38 130.1 0.0 1.6e-37 129.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 KPI87575.1 - 2e-16 59.8 0.0 2.8e-08 33.7 0.0 3.1 3 0 0 3 3 3 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 KPI87575.1 - 1.7e-11 44.3 0.1 1.8e-10 41.0 0.0 2.6 1 1 1 2 2 2 1 Peptidase C26 NAD_synthase PF02540.17 KPI87575.1 - 6e-09 35.4 0.1 0.00011 21.4 0.1 2.3 2 0 0 2 2 2 2 NAD synthase QueC PF06508.13 KPI87575.1 - 2.1e-05 24.1 0.0 0.00013 21.5 0.0 2.0 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 KPI87575.1 - 0.00024 20.8 0.2 0.0011 18.5 0.1 2.1 3 0 0 3 3 3 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 KPI87575.1 - 0.0021 17.4 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase ATP_bind_3 PF01171.20 KPI87575.1 - 0.0054 16.5 0.1 0.024 14.4 0.1 2.0 2 0 0 2 2 2 1 PP-loop family DJ-1_PfpI PF01965.24 KPI87575.1 - 0.0079 16.0 0.0 1.8 8.4 0.0 2.6 2 0 0 2 2 2 1 DJ-1/PfpI family Asn_synthase PF00733.21 KPI87575.1 - 0.0079 15.9 0.2 0.015 15.0 0.2 1.4 1 0 0 1 1 1 1 Asparagine synthase PAPS_reduct PF01507.19 KPI87575.1 - 0.0089 16.1 0.0 0.016 15.3 0.0 1.5 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family GATase_3 PF07685.14 KPI87575.1 - 0.016 14.8 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain tRNA_Me_trans PF03054.16 KPI87575.1 - 0.022 13.6 0.0 0.057 12.2 0.1 1.7 2 0 0 2 2 2 0 tRNA methyl transferase GP79 PF17463.2 KPI87575.1 - 0.14 12.1 0.3 0.34 11.0 0.3 1.6 1 0 0 1 1 1 0 Gene product 79 RRM_1 PF00076.22 KPI87576.1 - 3.3e-08 33.2 0.0 3.9e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NRN1 PF15056.6 KPI87577.1 - 0.011 15.8 0.6 0.011 15.8 0.6 2.2 2 0 0 2 2 2 0 Neuritin protein family DUF4726 PF15855.5 KPI87577.1 - 0.028 14.6 4.3 0.031 14.5 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4726) Tup_N PF08581.10 KPI87577.1 - 0.088 13.1 0.6 0.088 13.1 0.6 3.1 2 2 1 3 3 3 0 Tup N-terminal PIN_12 PF16289.5 KPI87577.1 - 0.69 10.4 12.2 0.24 11.9 3.6 2.1 2 0 0 2 2 2 0 PIN domain zf-CCCH PF00642.24 KPI87578.1 - 8.5e-06 25.5 11.3 0.0012 18.7 3.8 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KPI87578.1 - 0.021 15.5 1.9 0.021 15.5 1.9 2.4 2 0 0 2 2 2 0 Torus domain zf_CCCH_4 PF18345.1 KPI87578.1 - 4.7 7.4 15.1 0.31 11.1 6.0 2.7 2 0 0 2 2 2 0 Zinc finger domain BAG PF02179.16 KPI87579.1 - 7.5e-07 29.5 1.3 1.4e-06 28.6 1.3 1.3 1 0 0 1 1 1 1 BAG domain Dcc1 PF09724.9 KPI87580.1 - 6e-47 160.6 0.0 6.9e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 zf-CCCH_4 PF18044.1 KPI87581.1 - 1.1e-07 31.5 13.0 9.1e-05 22.2 2.6 3.1 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH PF00642.24 KPI87581.1 - 6.9e-07 29.0 14.5 6.3e-06 26.0 1.7 3.5 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI87581.1 - 8.2e-06 25.7 18.5 0.0028 17.7 2.8 3.5 4 0 0 4 4 4 2 Zinc finger domain Torus PF16131.5 KPI87581.1 - 9.9e-05 23.0 1.0 0.091 13.5 0.2 2.6 2 0 0 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 KPI87581.1 - 0.029 14.8 4.6 0.81 10.3 1.4 3.0 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Apolipoprotein PF01442.18 KPI87583.1 - 1.4e-05 25.0 15.9 1.4e-05 25.0 15.9 1.6 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 KPI87583.1 - 0.0013 19.2 25.0 0.014 15.9 9.7 3.5 2 1 2 4 4 3 2 Bacterial protein of unknown function (DUF883) DUF885 PF05960.11 KPI87583.1 - 0.0051 16.5 10.3 0.0053 16.5 10.3 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) ABC2_membrane_3 PF12698.7 KPI87583.1 - 0.025 13.7 2.2 0.032 13.4 2.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein ATG_C PF09333.11 KPI87583.1 - 0.032 14.6 0.6 0.032 14.6 0.6 3.6 2 1 1 3 3 3 0 Autophagy-related protein C terminal domain Phasin_2 PF09361.10 KPI87583.1 - 0.076 13.3 23.6 0.053 13.8 11.4 2.9 1 1 1 2 2 2 0 Phasin protein YtxH PF12732.7 KPI87583.1 - 0.095 13.2 30.1 4.7e+02 1.4 0.1 4.4 2 1 0 2 2 1 0 YtxH-like protein SOG2 PF10428.9 KPI87583.1 - 0.17 11.0 10.3 0.26 10.4 3.3 2.1 1 1 1 2 2 2 0 RAM signalling pathway protein ApoLp-III PF07464.11 KPI87583.1 - 0.17 11.9 25.9 0.48 10.5 12.1 2.8 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Prominin PF05478.11 KPI87583.1 - 0.24 9.3 7.5 1.1 7.2 6.5 2.0 1 1 0 1 1 1 0 Prominin PhaP_Bmeg PF09602.10 KPI87583.1 - 0.56 10.1 11.4 0.26 11.2 8.7 1.8 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) HisKA_3 PF07730.13 KPI87583.1 - 0.77 10.3 9.3 48 4.6 5.3 3.7 2 1 0 2 2 2 0 Histidine kinase AbiH PF14253.6 KPI87583.1 - 1.3 8.8 5.0 1.9 8.3 5.0 1.4 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH DUF948 PF06103.11 KPI87583.1 - 2 8.7 20.3 17 5.7 1.1 4.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Mis12 PF05859.12 KPI87583.1 - 2.3 8.3 5.2 11 6.1 0.1 2.7 2 1 0 2 2 2 0 Mis12 protein DUF357 PF04010.13 KPI87583.1 - 2.6 8.2 8.8 3.9 7.6 3.9 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF357) Mitofilin PF09731.9 KPI87583.1 - 2.7 6.7 25.9 2.8 6.7 25.7 1.3 1 1 0 1 1 1 0 Mitochondrial inner membrane protein Phage_Mu_Gam PF07352.12 KPI87583.1 - 6.2 6.7 20.9 0.95 9.4 5.9 3.3 3 1 0 3 3 3 0 Bacteriophage Mu Gam like protein zf-RING_UBOX PF13445.6 KPI87584.1 - 0.00036 20.5 8.9 0.00036 20.5 8.9 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KPI87584.1 - 0.00039 20.2 16.6 0.001 18.9 16.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KPI87584.1 - 0.048 13.5 11.3 0.1 12.5 11.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KPI87584.1 - 0.18 12.0 15.9 0.048 13.8 12.3 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-C3HC4 PF00097.25 KPI87584.1 - 0.49 10.3 22.1 0.036 13.9 16.5 2.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI87584.1 - 3.7 7.8 16.2 21 5.4 16.4 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DNA_pol_phi PF04931.13 KPI87585.1 - 0.001 17.3 10.1 0.001 17.3 10.1 5.3 4 2 2 6 6 6 2 DNA polymerase phi DUF5320 PF17253.2 KPI87585.1 - 0.78 10.8 6.4 3.5 8.7 6.4 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Aa_trans PF01490.18 KPI87586.1 - 3.3e-63 213.8 34.5 3.8e-63 213.6 34.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI87586.1 - 6.8e-07 28.7 16.9 6.8e-07 28.7 16.9 1.9 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family TMEM237 PF15383.6 KPI87586.1 - 0.17 10.9 0.5 0.38 9.8 0.5 1.5 1 0 0 1 1 1 0 Transmembrane protein 237 LRR_4 PF12799.7 KPI87587.1 - 8.6e-14 51.4 1.1 0.11 13.0 0.1 8.8 7 3 3 10 10 10 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87587.1 - 9.1e-05 22.1 9.0 1.1 9.1 0.1 7.5 7 1 0 7 7 7 2 Leucine rich repeat LRR_6 PF13516.6 KPI87587.1 - 0.00043 20.1 8.5 9.4 6.6 0.0 7.8 8 0 0 8 8 8 2 Leucine Rich repeat STAT1_TAZ2bind PF12162.8 KPI87588.1 - 0.23 11.1 0.5 0.43 10.2 0.5 1.4 1 0 0 1 1 1 0 STAT1 TAZ2 binding domain DUF4757 PF15949.5 KPI87590.1 - 2.6 8.5 6.1 27 5.2 2.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4757) dUTPase_2 PF08761.11 KPI87591.1 - 5.3e-43 147.1 0.0 7.2e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 dUTPase Ribosomal_L23 PF00276.20 KPI87592.1 - 1.5e-16 60.6 3.6 1.5e-16 60.6 3.6 2.5 2 1 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 KPI87592.1 - 0.01 16.0 8.1 0.01 16.0 8.1 2.0 2 0 0 2 2 2 0 Ribosomal protein L23, N-terminal domain TusA PF01206.17 KPI87592.1 - 0.022 14.6 0.1 0.05 13.4 0.1 1.7 1 0 0 1 1 1 0 Sulfurtransferase TusA Nop16 PF09420.10 KPI87594.1 - 1.4e-14 54.7 1.6 1.3e-11 44.9 0.8 2.1 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 DUF3435 PF11917.8 KPI87594.1 - 0.0048 15.9 0.5 0.0057 15.6 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) NTF2 PF02136.20 KPI87595.1 - 6.6e-27 94.5 0.2 7.3e-27 94.3 0.2 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 KPI87595.1 - 0.012 16.0 0.0 0.014 15.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 KPI87595.1 - 0.063 13.9 0.0 0.078 13.6 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Lumazine_bd_2 PF12893.7 KPI87595.1 - 0.11 13.2 0.1 0.19 12.4 0.1 1.4 1 0 0 1 1 1 0 Putative lumazine-binding A_deaminase PF00962.22 KPI87596.1 - 1.5e-09 37.7 3.1 1.9e-05 24.2 0.3 3.2 3 0 0 3 3 3 3 Adenosine/AMP deaminase Pkinase PF00069.25 KPI87597.1 - 4.1e-22 78.8 0.0 3.7e-17 62.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain APH PF01636.23 KPI87597.1 - 0.00018 21.5 0.6 0.00047 20.1 0.6 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF5428 PF17493.2 KPI87597.1 - 1.8 9.0 7.6 0.13 12.7 0.7 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5428) Peptidase_M30 PF10460.9 KPI87597.1 - 5.2 5.9 8.5 0.32 9.9 3.2 1.6 2 0 0 2 2 2 0 Peptidase M30 TPR_2 PF07719.17 KPI87598.1 - 0.00035 20.4 0.9 0.2 11.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87598.1 - 0.021 15.1 4.4 0.063 13.6 4.4 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2153 PF09921.9 KPI87598.1 - 0.04 13.7 0.2 0.081 12.8 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) TPR_1 PF00515.28 KPI87598.1 - 0.052 13.4 0.3 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat FRB_dom PF08771.11 KPI87598.1 - 0.079 13.4 0.1 0.21 12.0 0.1 1.7 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain TPR_9 PF13371.6 KPI87598.1 - 2.1 8.6 6.3 26 5.1 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat BetaGal_dom3 PF13363.6 KPI87599.1 - 0.033 13.8 0.1 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 Beta-galactosidase, domain 3 DFRP_C PF16543.5 KPI87601.1 - 1.9e-14 53.9 10.3 1.9e-14 53.9 10.3 2.8 2 1 0 2 2 2 1 DRG Family Regulatory Proteins, Tma46 WD40 PF00400.32 KPI87602.1 - 1.7e-64 212.2 16.4 2e-08 34.8 0.1 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI87602.1 - 9.1e-23 80.4 3.5 0.00014 22.1 0.1 7.3 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KPI87602.1 - 4.6e-13 49.2 2.8 0.039 13.3 0.1 6.5 4 2 3 7 7 7 3 WD40-like domain Nup160 PF11715.8 KPI87602.1 - 8.2e-10 37.9 10.6 0.079 11.6 0.3 5.6 2 1 5 7 7 7 4 Nucleoporin Nup120/160 eIF2A PF08662.11 KPI87602.1 - 5.1e-09 36.3 4.0 6.4e-05 22.9 0.1 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KPI87602.1 - 0.012 14.6 9.8 10 5.0 0.2 5.4 1 1 4 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CEP19 PF14933.6 KPI87602.1 - 0.017 15.5 0.0 0.027 14.8 0.0 1.2 1 0 0 1 1 1 0 CEP19-like protein DUF4934 PF16288.5 KPI87602.1 - 0.039 13.9 1.2 5.5 7.0 0.0 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF4934) Invasin_D3 PF09134.10 KPI87602.1 - 0.067 13.5 1.8 1.1 9.7 0.2 2.8 3 0 0 3 3 3 0 Invasin, domain 3 DUF5570 PF17731.1 KPI87602.1 - 0.12 12.5 12.2 2.7 8.1 0.1 5.2 1 1 3 5 5 5 0 Family of unknown function (DUF5570) CBM9_2 PF16011.5 KPI87602.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding family 9 MTHFR PF02219.17 KPI87603.1 - 2.1e-07 30.6 0.0 0.00064 19.1 0.0 3.1 3 0 0 3 3 3 2 Methylenetetrahydrofolate reductase DUF2564 PF10819.8 KPI87604.1 - 1.1 9.7 6.1 9 6.8 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) Hydin_ADK PF17213.3 KPI87606.1 - 0.022 15.1 4.6 0.028 14.7 4.6 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain G_path_suppress PF15991.5 KPI87606.1 - 0.058 13.5 12.0 0.062 13.4 12.0 1.1 1 0 0 1 1 1 0 G-protein pathway suppressor TFIIA PF03153.13 KPI87606.1 - 0.12 12.3 13.4 0.12 12.4 13.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 KPI87606.1 - 0.14 10.9 5.7 0.18 10.6 5.7 1.0 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 KPI87606.1 - 0.26 11.9 10.1 0.35 11.5 10.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 KPI87606.1 - 2.2 7.8 21.5 3.2 7.3 21.5 1.2 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 KPI87606.1 - 3.1 6.5 20.6 4.4 6.0 20.6 1.2 1 0 0 1 1 1 0 Androgen receptor dCMP_cyt_deam_1 PF00383.23 KPI87607.1 - 1e-08 34.9 4.6 0.0024 17.7 5.2 3.1 1 1 1 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KPI87607.1 - 6.8e-08 32.4 0.4 5.7e-05 22.9 0.0 3.0 2 1 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 KPI87607.1 - 0.24 11.5 2.0 0.83 9.7 2.0 2.0 1 1 0 1 1 1 0 Bd3614-like deaminase Aa_trans PF01490.18 KPI87608.1 - 6.8e-38 130.4 34.9 1.1e-37 129.7 34.9 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KPI87609.1 - 1.2e-35 123.0 31.2 1.8e-35 122.5 31.2 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein PEN-2 PF10251.9 KPI87609.1 - 0.47 10.9 3.2 2 8.9 0.0 3.2 3 0 0 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase RRM_1 PF00076.22 KPI87610.1 - 1.3e-41 140.3 0.3 7.4e-15 54.5 0.0 6.0 5 1 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI87610.1 - 8.7e-06 25.3 0.1 0.032 13.8 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KPI87610.1 - 1.8e-05 24.5 0.0 0.29 11.0 0.0 3.7 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KPI87610.1 - 0.0017 18.4 0.0 0.24 11.5 0.0 3.6 4 0 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KPI87610.1 - 0.015 15.3 0.1 0.64 10.1 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 KPI87610.1 - 0.067 13.0 0.1 2.7 7.8 0.0 3.3 4 0 0 4 4 4 0 Rrp7 RRM-like N-terminal domain BRF1 PF07741.13 KPI87610.1 - 0.57 10.5 11.2 3.9 7.9 6.8 2.9 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF4407 PF14362.6 KPI87610.1 - 1 8.6 10.4 2.4 7.4 10.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HEAT PF02985.22 KPI87611.1 - 7.4e-07 28.9 30.7 0.042 14.1 0.1 8.6 9 0 0 9 9 9 4 HEAT repeat HEAT_EZ PF13513.6 KPI87611.1 - 0.003 18.0 10.5 1.7 9.2 0.2 6.2 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 KPI87611.1 - 0.32 11.4 28.5 0.75 10.2 0.0 8.0 8 1 0 8 8 8 0 HEAT repeats Arm PF00514.23 KPI87611.1 - 1.3 9.1 7.4 7.9 6.7 0.0 5.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF1751 PF08551.10 KPI87613.1 - 0.0035 17.9 0.5 0.038 14.6 0.2 2.3 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) RNA_pol_Rpc4 PF05132.14 KPI87613.1 - 0.016 15.6 3.5 0.025 15.0 3.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 KPI87613.1 - 0.049 11.9 0.7 0.063 11.6 0.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 KPI87613.1 - 0.06 11.4 4.2 0.084 11.0 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4820 PF16091.5 KPI87613.1 - 0.25 10.7 1.0 0.37 10.1 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Spt20 PF12090.8 KPI87613.1 - 4.2 6.9 8.2 6.1 6.4 8.2 1.1 1 0 0 1 1 1 0 Spt20 family SelP_N PF04592.14 KPI87614.1 - 4.1 6.7 11.3 10 5.4 11.3 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Glycolytic PF00274.19 KPI87615.1 - 1.8e-130 434.7 0.0 2.1e-130 434.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Gln-synt_C PF00120.24 KPI87617.1 - 4.8e-17 62.0 0.0 1.9e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 KPI87617.1 - 4.1e-11 42.5 0.0 9.1e-11 41.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain 3Beta_HSD PF01073.19 KPI87619.1 - 8.5e-37 126.7 0.0 1.1e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KPI87619.1 - 8.3e-27 94.2 0.0 1.1e-26 93.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KPI87619.1 - 8.3e-16 58.4 0.0 1.1e-15 58.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 KPI87619.1 - 1.2e-15 57.4 0.0 7.7e-10 38.4 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 KPI87619.1 - 1.5e-12 47.6 0.0 2.3e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KPI87619.1 - 1.4e-09 37.5 0.0 2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KPI87619.1 - 8.1e-09 35.0 0.0 1.4e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 KPI87619.1 - 3e-07 30.2 0.0 4.6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 KPI87619.1 - 0.0013 18.7 0.1 0.0057 16.6 0.1 2.0 2 1 0 2 2 2 1 KR domain adh_short PF00106.25 KPI87619.1 - 0.0036 16.8 0.1 0.01 15.3 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 KPI87619.1 - 0.018 15.3 0.0 0.075 13.3 0.0 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Peptidase_S9 PF00326.21 KPI87620.1 - 4.5e-31 108.0 0.0 8.3e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 KPI87620.1 - 1.2e-22 80.4 0.0 1.9e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain TPR_2 PF07719.17 KPI87621.1 - 0.091 12.9 3.6 10 6.5 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5446 PF17522.2 KPI87621.1 - 1.2 9.3 4.1 3.3 7.9 4.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5446) TPR_19 PF14559.6 KPI87621.1 - 2.1 8.9 9.3 0.53 10.8 4.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BT1 PF03092.16 KPI87623.1 - 7e-203 674.6 8.3 8.1e-203 674.4 8.3 1.0 1 0 0 1 1 1 1 BT1 family zf-MYND PF01753.18 KPI87624.1 - 1.8e-11 43.9 10.7 1.8e-11 43.9 10.7 1.9 2 0 0 2 2 2 1 MYND finger VWA_CoxE PF05762.14 KPI87624.1 - 0.0048 16.3 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein zf-C6H2 PF15801.5 KPI87624.1 - 0.022 15.1 5.6 0.022 15.1 5.6 2.7 3 1 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding RNase_H PF00075.24 KPI87625.1 - 1.4e-29 103.1 0.9 4.8e-20 72.2 0.0 3.0 1 1 1 2 2 2 2 RNase H Cauli_VI PF01693.16 KPI87625.1 - 1e-20 73.8 0.5 2.5e-20 72.5 0.5 1.7 1 0 0 1 1 1 1 Caulimovirus viroplasmin NDUF_B6 PF09782.9 KPI87625.1 - 0.11 12.6 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit FHA PF00498.26 KPI87627.1 - 0.0036 17.6 0.0 0.0078 16.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KPI87627.1 - 0.093 13.1 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain XRN_N PF03159.18 KPI87629.1 - 2.4e-92 308.8 0.0 3.6e-92 308.2 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KPI87629.1 - 4.3e-78 263.2 1.3 2.2e-54 185.1 0.3 2.2 1 1 1 2 2 2 2 Xrn1 helical domain XRN1_D1 PF18332.1 KPI87629.1 - 6.2e-23 81.6 0.0 9.7e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 KPI87629.1 - 6.2e-16 58.3 0.1 2e-15 56.6 0.1 2.0 2 0 0 2 2 2 1 Xrn1 SH3-like domain TFIIA PF03153.13 KPI87629.1 - 5.7 6.8 7.1 8.7 6.2 7.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Leu_zip PF15294.6 KPI87630.1 - 4e-14 52.8 12.4 1.4e-07 31.3 1.4 2.5 1 1 1 2 2 2 2 Leucine zipper V-ATPase_G_2 PF16999.5 KPI87630.1 - 0.0024 18.3 16.3 0.068 13.6 0.4 2.5 1 1 0 2 2 2 2 Vacuolar (H+)-ATPase G subunit FAM184 PF15665.5 KPI87630.1 - 0.005 16.6 9.6 0.0086 15.9 9.6 1.3 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B OSK PF17182.4 KPI87630.1 - 0.019 14.2 0.0 0.051 12.8 0.0 1.7 1 0 0 1 1 1 0 OSK domain HIP1_clath_bdg PF16515.5 KPI87630.1 - 0.033 14.8 4.7 0.033 14.8 4.7 3.6 3 2 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Lebercilin PF15619.6 KPI87630.1 - 0.046 13.4 13.0 0.12 12.0 13.0 1.7 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF5082 PF16888.5 KPI87630.1 - 0.052 13.8 6.9 0.11 12.7 6.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) ATG16 PF08614.11 KPI87630.1 - 0.18 12.0 18.9 0.35 11.1 3.4 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 KPI87630.1 - 0.19 12.0 15.5 5.7 7.2 13.1 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 KPI87630.1 - 0.39 10.0 13.2 0.73 9.1 8.6 2.3 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF148 PF02520.17 KPI87630.1 - 0.75 9.9 8.9 1.8 8.7 5.4 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF148 FliJ PF02050.16 KPI87630.1 - 0.82 9.9 19.5 1.7e+02 2.4 18.6 2.7 1 1 1 2 2 2 0 Flagellar FliJ protein DUF1104 PF06518.11 KPI87630.1 - 0.84 10.0 4.7 2.7 8.4 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) Filament PF00038.21 KPI87630.1 - 1.1 8.7 15.1 1.1 8.8 8.5 2.3 1 1 1 2 2 2 0 Intermediate filament protein HAUS6_N PF14661.6 KPI87630.1 - 1.3 8.5 11.2 4.2 6.9 11.2 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Atg14 PF10186.9 KPI87630.1 - 1.4 7.9 10.0 5.5 6.0 10.0 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 KPI87630.1 - 1.5 8.9 10.0 1 9.4 2.4 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Spectrin PF00435.21 KPI87630.1 - 1.7 9.2 9.9 4 8.0 6.6 2.4 1 1 1 2 2 2 0 Spectrin repeat Cob_adeno_trans PF01923.18 KPI87630.1 - 3.2 7.9 9.6 18 5.4 4.4 2.7 1 1 0 2 2 2 0 Cobalamin adenosyltransferase TetR_C_15 PF17918.1 KPI87630.1 - 3.3 8.5 8.9 5.4 7.8 4.6 2.7 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Swi5 PF07061.11 KPI87630.1 - 3.7 7.7 7.7 1.7 8.8 0.7 3.2 3 0 0 3 3 3 0 Swi5 FHA PF00498.26 KPI87634.1 - 5.8e-10 39.4 0.0 3.1e-09 37.0 0.0 2.2 1 1 0 1 1 1 1 FHA domain Host_attach PF10116.9 KPI87636.1 - 0.25 11.9 5.0 1.4 9.5 0.8 2.7 2 0 0 2 2 2 0 Protein required for attachment to host cells Kinesin PF00225.23 KPI87638.1 - 1.1e-72 244.8 0.0 1.7e-72 244.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI87638.1 - 1.8e-12 47.4 0.0 9.5e-11 41.8 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding AAA_16 PF13191.6 KPI87638.1 - 0.064 13.6 1.1 0.13 12.6 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain Trm112p PF03966.16 KPI87639.1 - 2.2e-08 34.6 0.1 3.3e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 Trm112p-like protein zf-RING_4 PF14570.6 KPI87639.1 - 0.15 11.8 1.2 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain HALZ PF02183.18 KPI87639.1 - 0.18 12.0 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper zinc_ribbon_4 PF13717.6 KPI87639.1 - 0.26 11.2 1.6 0.32 10.9 0.1 1.9 2 0 0 2 2 2 0 zinc-ribbon domain HD PF01966.22 KPI87640.1 - 2e-13 50.6 0.1 4.3e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 KPI87640.1 - 0.00052 19.8 0.0 0.00086 19.1 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HDOD PF08668.12 KPI87640.1 - 0.01 15.3 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 HDOD domain Proteasome PF00227.26 KPI87642.1 - 5.1e-30 104.4 0.0 6.8e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit DUF1768 PF08719.11 KPI87643.1 - 4.1e-25 88.9 0.0 5e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Pro_isomerase PF00160.21 KPI87644.1 - 2.5e-50 170.8 0.3 2.9e-50 170.6 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CytochromB561_N PF09786.9 KPI87645.1 - 0.00029 20.0 0.0 0.00044 19.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome B561, N terminal Filament PF00038.21 KPI87646.1 - 0.0033 17.1 37.9 0.0033 17.1 37.9 7.9 3 3 4 7 7 7 6 Intermediate filament protein IFT81_CH PF18383.1 KPI87647.1 - 1.5e-30 106.0 0.1 4.1e-30 104.6 0.1 1.8 1 0 0 1 1 1 1 Intraflagellar transport 81 calponin homology domain Baculo_PEP_C PF04513.12 KPI87647.1 - 0.0007 19.7 21.8 0.32 11.0 1.7 6.5 3 1 3 6 6 6 4 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KPI87647.1 - 0.0015 17.5 10.4 0.0015 17.5 10.4 4.1 2 1 0 4 4 4 2 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 KPI87647.1 - 0.0041 17.3 0.2 0.0041 17.3 0.2 6.0 1 1 4 6 6 6 2 Seryl-tRNA synthetase N-terminal domain IZUMO PF15005.6 KPI87647.1 - 1.1 9.8 17.1 0.9 10.0 0.2 4.7 2 2 2 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated DUF948 PF06103.11 KPI87647.1 - 1.2 9.5 4.8 6.3 7.1 0.3 3.8 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) EMP24_GP25L PF01105.24 KPI87648.1 - 8.3e-09 35.6 1.7 4e-08 33.4 1.7 2.0 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MCU PF04678.13 KPI87648.1 - 0.016 15.3 1.4 0.021 14.9 0.6 1.6 2 0 0 2 2 2 0 Mitochondrial calcium uniporter LpxI_N PF17930.1 KPI87648.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 LpxI N-terminal domain CS PF04969.16 KPI87649.1 - 6.7e-09 36.7 0.0 1.1e-08 36.0 0.0 1.3 1 0 0 1 1 1 1 CS domain DUF1935 PF09149.10 KPI87650.1 - 4.7e-121 396.3 0.1 9.3e-33 112.7 0.0 4.1 4 0 0 4 4 4 4 Domain of unknown function (DUF1935) EGF_alliinase PF04863.13 KPI87650.1 - 0.01 16.2 0.1 0.024 15.0 0.1 1.6 1 0 0 1 1 1 0 Alliinase EGF-like domain DUF3991 PF13154.6 KPI87650.1 - 0.017 15.5 0.1 1.6 9.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3991) DUF1935 PF09149.10 KPI87651.1 - 2e-113 371.8 3.0 9.2e-32 109.5 0.1 4.1 4 0 0 4 4 4 4 Domain of unknown function (DUF1935) DUF4051 PF13260.6 KPI87652.1 - 0.07 12.9 0.8 0.31 10.8 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) Nop25 PF09805.9 KPI87654.1 - 6.5e-06 26.7 14.8 6.5e-06 26.7 14.8 3.1 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) AdoMet_MTase PF07757.13 KPI87654.1 - 0.061 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Ldh_1_C PF02866.18 KPI87655.1 - 2.7e-42 144.6 0.0 5e-42 143.7 0.0 1.4 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KPI87655.1 - 4.1e-39 133.9 0.0 5.5e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 KPI87655.1 - 0.044 14.2 0.0 0.08 13.4 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 KPI87656.1 - 1.7e-37 128.9 0.0 2.4e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KPI87656.1 - 5.1e-35 120.6 0.0 6.9e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KPI87656.1 - 1.7e-06 27.3 0.0 2.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 KPI87656.1 - 0.0095 16.4 0.0 0.023 15.2 0.0 1.7 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KPI87656.1 - 0.1 11.9 0.0 0.58 9.5 0.0 2.0 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_C PF02866.18 KPI87657.1 - 6.1e-47 159.7 0.0 1.1e-46 158.8 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KPI87657.1 - 4.1e-43 146.8 0.3 5.9e-43 146.3 0.3 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 KPI87657.1 - 0.015 15.7 0.2 0.035 14.5 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 KPI87657.1 - 0.018 15.2 0.0 0.038 14.1 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 KPI87657.1 - 0.023 13.7 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KPI87657.1 - 0.044 13.7 0.1 0.076 12.9 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 KPI87657.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ldh_1_C PF02866.18 KPI87658.1 - 6.9e-18 65.1 0.0 1.8e-09 37.7 0.0 2.3 2 0 0 2 2 2 2 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KPI87658.1 - 1.2e-15 57.8 0.0 2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain ADK PF00406.22 KPI87659.1 - 3.8e-29 101.7 0.0 4.7e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KPI87659.1 - 9.9e-14 51.9 0.0 2e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KPI87659.1 - 1e-11 44.6 0.0 2.4e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 KPI87659.1 - 4.4e-08 33.7 0.2 0.0049 17.2 0.0 2.4 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain AAA_28 PF13521.6 KPI87659.1 - 0.0028 17.9 0.0 0.0051 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI87659.1 - 0.0074 16.8 0.0 0.019 15.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI87659.1 - 0.008 16.3 0.1 0.018 15.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain Phage_holin_3_7 PF05449.11 KPI87659.1 - 0.019 14.9 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative 3TM holin, Phage_holin_3 Cytidylate_kin PF02224.18 KPI87659.1 - 0.03 14.0 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase RuvB_N PF05496.12 KPI87659.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.6 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 KPI87659.1 - 0.14 12.6 0.3 0.7 10.3 0.3 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ADK PF00406.22 KPI87660.1 - 6e-51 172.5 0.0 7.2e-51 172.2 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KPI87660.1 - 1.8e-23 83.5 0.0 2.9e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KPI87660.1 - 8.8e-15 54.4 0.2 2e-14 53.3 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.6 KPI87660.1 - 0.00066 20.2 0.0 0.0014 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI87660.1 - 0.0058 16.8 0.0 0.016 15.4 0.0 1.8 2 1 0 2 2 2 1 AAA domain Hydin_ADK PF17213.3 KPI87660.1 - 0.093 13.0 0.0 0.7 10.1 0.0 2.1 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain AAA_28 PF13521.6 KPI87660.1 - 0.1 12.8 0.2 0.37 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Herpes_UL52 PF03121.15 KPI87661.1 - 0.054 13.4 5.4 0.11 12.5 5.4 1.4 1 0 0 1 1 1 0 Herpesviridae UL52/UL70 DNA primase PCI PF01399.27 KPI87662.1 - 0.0024 18.4 0.0 0.0057 17.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain HPP PF04982.13 KPI87663.1 - 2.8e-29 101.8 8.3 4.4e-29 101.1 8.3 1.3 1 0 0 1 1 1 1 HPP family HPP PF04982.13 KPI87664.1 - 4.3e-25 88.3 7.7 6.6e-25 87.7 7.7 1.3 1 0 0 1 1 1 1 HPP family DUF4175 PF13779.6 KPI87664.1 - 0.28 9.0 0.4 0.37 8.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) G6PD_C PF02781.16 KPI87665.1 - 4.4e-110 367.4 0.0 5.9e-110 367.0 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 KPI87665.1 - 2.6e-57 194.3 0.0 4.9e-57 193.4 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain RIIa PF02197.17 KPI87665.1 - 0.062 13.0 1.1 0.83 9.4 0.1 3.0 3 0 0 3 3 3 0 Regulatory subunit of type II PKA R-subunit peroxidase PF00141.23 KPI87666.1 - 3.1e-44 151.4 0.0 5.5e-44 150.6 0.0 1.4 1 1 0 1 1 1 1 Peroxidase Shadoo PF14999.6 KPI87666.1 - 0.032 14.3 1.4 0.054 13.6 1.0 1.6 1 1 0 1 1 1 0 Shadow of prion protein, neuroprotective Pex24p PF06398.11 KPI87667.1 - 0.02 13.9 1.6 0.034 13.1 1.6 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin CLPTM1 PF05602.12 KPI87669.1 - 1.6e-95 320.7 0.0 2.1e-95 320.3 0.0 1.2 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DnaJ PF00226.31 KPI87670.1 - 0.034 14.3 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain Pkinase PF00069.25 KPI87671.1 - 1.5e-42 145.8 0.0 1.9e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87671.1 - 3.5e-22 79.0 0.0 4.1e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87671.1 - 8.2e-07 28.6 0.0 1.7e-06 27.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like PIP49_C PF12260.8 KPI87671.1 - 0.088 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 LRR_4 PF12799.7 KPI87672.1 - 1.6e-10 41.1 1.9 0.024 15.1 0.0 4.8 1 1 5 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87672.1 - 4.3e-05 23.2 1.1 0.086 12.6 0.1 3.4 1 1 3 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KPI87672.1 - 0.014 15.4 11.9 8.7 6.7 0.0 6.0 7 0 0 7 7 7 0 Leucine Rich repeat LRR_9 PF14580.6 KPI87672.1 - 0.063 12.8 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.33 KPI87672.1 - 0.34 11.6 6.0 9.2 7.3 0.5 4.6 4 2 0 4 4 4 0 Leucine Rich Repeat adh_short PF00106.25 KPI87673.1 - 4.6e-37 127.4 0.1 6.3e-37 126.9 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI87673.1 - 7.9e-22 78.0 0.1 1e-21 77.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI87673.1 - 6.4e-06 26.2 0.6 1.3e-05 25.2 0.1 1.6 2 0 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 KPI87673.1 - 0.0018 18.6 0.1 0.0038 17.5 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Exog_C PF18026.1 KPI87673.1 - 0.0039 17.2 0.1 0.014 15.4 0.1 1.9 2 0 0 2 2 2 1 Endo/exonuclease (EXOG) C-terminal domain NAD_binding_2 PF03446.15 KPI87673.1 - 0.019 15.1 0.0 0.051 13.7 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 KPI87673.1 - 0.021 14.3 0.1 0.034 13.6 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF853 PF05872.12 KPI87674.1 - 0.11 11.1 9.8 0.13 10.8 9.8 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Neur_chan_memb PF02932.16 KPI87674.1 - 5.9 6.9 6.9 5.8 6.9 6.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIE PF07228.12 KPI87675.1 - 1.8e-05 24.8 0.0 0.061 13.2 0.0 3.2 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KPI87675.1 - 0.04 13.5 0.0 0.097 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein phosphatase 2C PP2C PF00481.21 KPI87675.1 - 0.11 12.1 0.0 16 5.0 0.0 2.6 3 0 0 3 3 3 0 Protein phosphatase 2C eIF-1a PF01176.19 KPI87676.1 - 0.024 14.4 0.0 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 NOA36 PF06524.12 KPI87676.1 - 0.23 10.8 7.5 0.28 10.4 7.5 1.1 1 0 0 1 1 1 0 NOA36 protein RAI16-like PF10257.9 KPI87677.1 - 1.6e-05 24.0 0.1 0.00083 18.3 0.0 2.8 2 1 0 2 2 2 2 Retinoic acid induced 16-like protein JmjC PF02373.22 KPI87678.1 - 1.9e-10 41.1 4.0 5.6e-09 36.4 4.0 2.3 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KPI87678.1 - 0.0034 17.1 0.0 0.098 12.3 0.0 2.5 3 0 0 3 3 3 1 Cupin-like domain CCD PF07860.11 KPI87678.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 WisP family C-Terminal Region TPR_16 PF13432.6 KPI87680.1 - 4.2e-23 81.7 12.4 9.7e-05 22.9 0.0 7.5 7 1 1 8 8 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87680.1 - 9e-23 79.1 44.5 2.5e-06 27.1 0.8 11.3 12 0 0 12 12 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87680.1 - 2.6e-20 70.8 44.8 0.00018 21.4 0.4 11.7 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_8 PF13181.6 KPI87680.1 - 2.2e-17 61.8 24.4 0.00046 20.2 0.3 9.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87680.1 - 7.1e-17 61.5 31.8 1.4e-05 25.3 0.0 9.2 6 2 4 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87680.1 - 2.4e-16 60.0 16.1 0.0016 18.9 0.0 7.6 6 2 3 9 9 8 5 Tetratricopeptide repeat TPR_6 PF13174.6 KPI87680.1 - 1.8e-15 56.4 20.1 0.0061 17.1 0.0 10.6 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87680.1 - 7e-13 47.6 24.8 0.026 14.5 0.0 9.8 11 0 0 11 11 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87680.1 - 1.2e-11 44.4 12.9 0.11 13.4 0.0 9.1 5 3 5 10 10 10 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87680.1 - 1.3e-07 31.2 20.3 5.3e-05 22.8 0.1 7.0 9 0 0 9 9 8 3 TPR repeat ANAPC3 PF12895.7 KPI87680.1 - 4.3e-07 30.1 23.6 0.002 18.3 0.2 6.8 5 2 3 8 8 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KPI87680.1 - 2.9e-06 27.3 21.6 0.084 13.3 0.1 9.0 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 KPI87680.1 - 0.00019 21.5 4.5 1.5 9.0 0.0 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_21 PF09976.9 KPI87680.1 - 0.00022 21.0 10.9 0.00027 20.7 1.1 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat-like domain Rapsyn_N PF10579.9 KPI87680.1 - 0.0012 18.9 0.2 3.4 7.8 0.0 3.2 2 1 0 2 2 2 2 Rapsyn N-terminal myristoylation and linker region DUF3808 PF10300.9 KPI87680.1 - 0.0024 16.7 6.1 0.015 14.1 0.1 2.7 3 1 0 3 3 3 2 Protein of unknown function (DUF3808) ComR_TPR PF18710.1 KPI87680.1 - 0.0088 15.6 4.4 1.3 8.5 0.2 2.6 2 0 0 2 2 2 2 ComR tetratricopeptide TPR_4 PF07721.14 KPI87680.1 - 0.12 13.0 0.1 37 5.4 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI87680.1 - 0.28 11.1 27.8 15 5.6 0.1 8.2 9 0 0 9 9 9 0 Tetratricopeptide repeat PPR PF01535.20 KPI87680.1 - 0.56 10.6 11.5 30 5.1 0.0 7.2 8 0 0 8 8 7 0 PPR repeat Fis1_TPR_C PF14853.6 KPI87680.1 - 10 6.3 16.1 16 5.7 0.1 6.6 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat WGG PF10273.9 KPI87682.1 - 2.1e-05 25.1 3.1 7.7e-05 23.3 3.1 1.9 1 1 0 1 1 1 1 Pre-rRNA-processing protein TSR2 Glyco_transf_43 PF03360.16 KPI87682.1 - 0.027 14.3 0.1 0.045 13.6 0.0 1.3 1 1 0 1 1 1 0 Glycosyltransferase family 43 MRP PF09387.10 KPI87683.1 - 9.4e-37 126.9 0.1 9.4e-37 126.9 0.1 1.7 2 0 0 2 2 2 1 Mitochondrial RNA binding protein MRP DUF4776 PF16003.5 KPI87684.1 - 3.4 6.6 12.6 0.11 11.5 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) Merozoite_SPAM PF07133.11 KPI87684.1 - 5.2 7.0 17.4 1.4 8.9 7.4 2.2 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) EBP PF05241.12 KPI87685.1 - 1.4e-12 47.5 6.3 1.8e-12 47.0 6.3 1.1 1 0 0 1 1 1 1 Emopamil binding protein TPR_14 PF13428.6 KPI87686.1 - 9.7e-11 41.6 34.9 0.6 11.1 0.0 12.8 9 3 4 13 13 13 4 Tetratricopeptide repeat TPR_17 PF13431.6 KPI87686.1 - 1.6e-07 31.2 10.2 1.5 9.4 0.0 8.2 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87686.1 - 0.0025 18.1 1.7 0.0025 18.1 1.7 11.1 10 2 1 11 11 11 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87686.1 - 0.014 15.2 12.3 8.2 6.4 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87686.1 - 0.034 14.2 21.7 2.3 8.5 0.1 8.0 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87686.1 - 0.075 12.7 2.2 5.7 6.7 0.0 4.7 6 0 0 6 6 6 0 TPR repeat TPR_8 PF13181.6 KPI87686.1 - 0.083 13.1 12.3 62 4.2 0.0 7.8 9 0 0 9 9 8 0 Tetratricopeptide repeat DUF3164 PF11363.8 KPI87686.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) TPR_4 PF07721.14 KPI87686.1 - 0.17 12.6 3.8 1.1 10.0 0.1 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87686.1 - 0.75 10.1 33.9 17 5.8 0.0 11.4 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87686.1 - 1.4 9.4 29.4 2.8 8.5 1.1 9.2 11 0 0 11 11 11 0 Tetratricopeptide repeat AAA PF00004.29 KPI87687.1 - 2e-37 128.6 0.0 4.2e-28 98.4 0.0 3.4 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI87687.1 - 4.2e-14 53.0 3.2 5.1e-06 26.8 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KPI87687.1 - 4e-09 37.1 6.5 0.0038 17.6 0.1 4.1 3 2 1 4 4 3 2 AAA ATPase domain AAA_18 PF13238.6 KPI87687.1 - 8.2e-09 36.1 0.0 0.00057 20.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KPI87687.1 - 2.1e-08 34.1 0.1 1.6e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 KPI87687.1 - 7.4e-08 32.7 0.0 0.00026 21.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KPI87687.1 - 2.9e-07 30.1 0.0 0.00043 19.7 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KPI87687.1 - 3.8e-07 30.4 0.0 0.015 15.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 KPI87687.1 - 4.7e-07 30.4 0.0 0.044 14.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_5 PF07728.14 KPI87687.1 - 8.5e-07 29.0 0.0 0.008 16.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 KPI87687.1 - 8.6e-07 29.3 0.1 0.0002 21.7 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 KPI87687.1 - 2.2e-06 27.4 0.1 2.2e-06 27.4 0.1 2.1 2 0 0 2 2 1 1 AAA+ lid domain AAA_24 PF13479.6 KPI87687.1 - 2.3e-06 27.5 0.0 0.03 14.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 KPI87687.1 - 1.3e-05 25.2 0.0 0.012 15.6 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 KPI87687.1 - 1.8e-05 24.6 0.5 0.014 15.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 KPI87687.1 - 3.9e-05 23.0 0.0 0.0088 15.3 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain DUF2075 PF09848.9 KPI87687.1 - 4.1e-05 23.0 0.0 0.034 13.4 0.0 2.5 3 0 0 3 3 2 2 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 KPI87687.1 - 4.5e-05 23.2 0.0 0.35 10.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 KPI87687.1 - 7.5e-05 23.1 0.0 0.54 10.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KPI87687.1 - 7.6e-05 23.1 0.0 0.45 10.9 0.0 2.8 3 0 0 3 3 2 2 RNA helicase NB-ARC PF00931.22 KPI87687.1 - 0.00017 20.9 0.1 0.062 12.5 0.0 2.9 2 1 1 3 3 3 1 NB-ARC domain AAA_14 PF13173.6 KPI87687.1 - 0.0002 21.4 0.0 0.027 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KPI87687.1 - 0.00029 20.5 0.1 0.089 12.5 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain TniB PF05621.11 KPI87687.1 - 0.00035 20.0 0.0 0.04 13.3 0.0 2.9 2 1 0 2 2 2 1 Bacterial TniB protein AAA_25 PF13481.6 KPI87687.1 - 0.00039 20.1 5.3 0.51 9.9 0.2 4.5 4 1 1 5 5 4 1 AAA domain Parvo_NS1 PF01057.17 KPI87687.1 - 0.00056 19.1 0.0 0.049 12.7 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 KPI87687.1 - 0.00072 19.7 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 KPI87687.1 - 0.00077 19.5 0.0 0.86 9.6 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KPI87687.1 - 0.00077 19.0 0.0 0.21 11.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_17 PF13207.6 KPI87687.1 - 0.00097 19.6 0.0 1.5 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KPI87687.1 - 0.0019 17.9 0.0 0.018 14.8 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 KPI87687.1 - 0.0032 17.4 0.0 0.7 9.8 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 KPI87687.1 - 0.0035 17.1 0.0 0.79 9.5 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 KPI87687.1 - 0.0036 17.1 0.2 4.2 7.1 0.0 3.0 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 KPI87687.1 - 0.0049 16.8 0.1 0.62 10.0 0.0 3.3 3 0 0 3 3 3 1 NTPase ATPase PF06745.13 KPI87687.1 - 0.0076 15.6 0.5 2.1 7.6 0.5 2.7 2 1 1 3 3 3 1 KaiC KTI12 PF08433.10 KPI87687.1 - 0.0083 15.6 0.0 1.1 8.7 0.0 2.8 3 0 0 3 3 3 1 Chromatin associated protein KTI12 MeaB PF03308.16 KPI87687.1 - 0.012 14.6 0.1 0.045 12.7 0.1 2.0 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ploopntkinase3 PF18751.1 KPI87687.1 - 0.018 14.9 0.0 0.071 13.0 0.0 2.0 2 0 0 2 2 1 0 P-loop Nucleotide Kinase3 T2SSE PF00437.20 KPI87687.1 - 0.022 13.8 0.0 0.1 11.7 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 KPI87687.1 - 0.022 14.9 0.1 0.094 12.8 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase TrwB_AAD_bind PF10412.9 KPI87687.1 - 0.049 12.5 0.6 1.1 8.1 0.1 3.0 4 0 0 4 4 3 0 Type IV secretion-system coupling protein DNA-binding domain 6PF2K PF01591.18 KPI87687.1 - 0.05 12.9 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Zeta_toxin PF06414.12 KPI87687.1 - 0.09 12.0 0.0 1 8.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin PPV_E1_C PF00519.17 KPI87687.1 - 0.094 11.5 0.0 5.9 5.6 0.0 2.1 2 0 0 2 2 2 0 Papillomavirus helicase AAA_23 PF13476.6 KPI87687.1 - 0.11 13.0 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Aminotran_5 PF00266.19 KPI87688.1 - 3.3e-83 279.7 0.0 5.3e-83 279.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KPI87688.1 - 1.1e-07 31.5 0.1 1.8e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KPI87688.1 - 0.012 14.9 0.2 0.022 14.1 0.2 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family AAA PF00004.29 KPI87689.1 - 2.9e-87 289.8 0.0 1.3e-47 161.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI87689.1 - 1.8e-23 82.0 1.3 1.4e-10 40.8 0.0 3.2 3 0 0 3 3 2 2 AAA+ lid domain RuvB_N PF05496.12 KPI87689.1 - 1.9e-15 57.0 0.0 1.7e-07 31.1 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KPI87689.1 - 1.7e-12 48.0 1.1 0.00057 20.3 0.0 4.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 KPI87689.1 - 4.4e-11 43.2 0.0 2.5e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KPI87689.1 - 7.8e-11 42.1 0.1 0.00046 20.2 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KPI87689.1 - 7.1e-09 36.1 0.4 0.013 15.7 0.0 4.2 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.6 KPI87689.1 - 5.3e-08 33.1 0.0 0.015 15.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 KPI87689.1 - 3.8e-07 30.2 0.0 0.014 15.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KPI87689.1 - 1.3e-06 28.7 0.0 0.034 14.5 0.0 3.1 3 0 0 3 3 2 2 RNA helicase IstB_IS21 PF01695.17 KPI87689.1 - 4.3e-06 26.6 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 KPI87689.1 - 1.2e-05 25.9 0.0 0.065 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 KPI87689.1 - 1.4e-05 25.1 0.0 0.23 11.4 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 KPI87689.1 - 2.9e-05 23.5 0.1 0.049 13.0 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 KPI87689.1 - 2.9e-05 23.4 0.0 0.021 14.1 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin TIP49 PF06068.13 KPI87689.1 - 3e-05 23.4 0.0 0.23 10.6 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Vps4_C PF09336.10 KPI87689.1 - 3.4e-05 23.8 0.0 0.004 17.1 0.1 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_3 PF07726.11 KPI87689.1 - 4.8e-05 23.2 0.0 0.41 10.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KPI87689.1 - 6e-05 23.0 0.2 0.23 11.4 0.0 2.9 3 0 0 3 3 3 2 NACHT domain AAA_28 PF13521.6 KPI87689.1 - 7.6e-05 23.0 0.0 0.37 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 KPI87689.1 - 0.00013 21.8 0.0 0.5 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 KPI87689.1 - 0.00016 22.2 0.1 0.39 11.2 0.0 2.8 2 1 0 2 2 2 1 ABC transporter AAA_11 PF13086.6 KPI87689.1 - 0.00021 21.2 0.0 0.38 10.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KPI87689.1 - 0.00051 19.8 0.0 0.09 12.5 0.0 2.8 3 0 0 3 3 2 1 Sigma-54 interaction domain AAA_17 PF13207.6 KPI87689.1 - 0.00072 20.0 0.0 0.33 11.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KPI87689.1 - 0.00093 18.5 0.2 0.8 8.8 0.0 3.1 3 1 1 4 4 3 1 NB-ARC domain Viral_helicase1 PF01443.18 KPI87689.1 - 0.0011 18.8 0.0 0.52 10.0 0.0 2.6 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 KPI87689.1 - 0.0011 18.9 0.2 0.15 12.0 0.0 2.7 2 0 0 2 2 2 1 NTPase AAA_7 PF12775.7 KPI87689.1 - 0.0015 18.1 0.0 0.63 9.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Rad17 PF03215.15 KPI87689.1 - 0.0016 18.4 0.0 0.076 12.9 0.0 2.4 2 1 0 2 2 2 1 Rad17 P-loop domain ATPase_2 PF01637.18 KPI87689.1 - 0.0017 18.3 0.0 0.34 10.8 0.0 2.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 KPI87689.1 - 0.0028 17.8 0.0 0.047 13.8 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain Bac_DnaA PF00308.18 KPI87689.1 - 0.0033 17.3 0.0 1.5 8.6 0.0 2.7 3 0 0 3 3 2 1 Bacterial dnaA protein AAA_25 PF13481.6 KPI87689.1 - 0.0043 16.6 2.7 2.6 7.6 0.1 3.8 2 2 2 4 4 4 1 AAA domain Parvo_NS1 PF01057.17 KPI87689.1 - 0.0045 16.1 0.1 0.44 9.6 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 KPI87689.1 - 0.0047 17.3 0.1 4.1 7.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI87689.1 - 0.022 14.5 0.1 7 6.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 KPI87689.1 - 0.025 13.7 0.0 3.3 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TniB PF05621.11 KPI87689.1 - 0.094 12.1 0.0 22 4.4 0.0 3.0 3 0 0 3 3 3 0 Bacterial TniB protein Terminase_4 PF05119.12 KPI87689.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Phage terminase, small subunit ATPase PF06745.13 KPI87689.1 - 0.17 11.2 0.2 3.1 7.1 0.0 2.6 2 1 1 3 3 3 0 KaiC AAA_29 PF13555.6 KPI87689.1 - 0.3 10.9 1.5 5.7 6.8 0.0 2.7 3 0 0 3 3 2 0 P-loop containing region of AAA domain Nup54_57_C PF18570.1 KPI87691.1 - 0.089 12.4 0.4 0.17 11.5 0.4 1.4 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain dsDNA_bind PF01984.20 KPI87691.1 - 1.7 9.0 6.1 1.5 9.2 0.3 2.8 3 0 0 3 3 3 0 Double-stranded DNA-binding domain Sec6 PF06046.13 KPI87694.1 - 2.2e-13 49.4 2.6 9.2e-09 34.2 0.2 2.4 2 0 0 2 2 2 2 Exocyst complex component Sec6 TatD_DNase PF01026.21 KPI87695.1 - 2e-38 132.2 0.0 2.5e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 KPI87695.1 - 0.047 13.5 0.0 1.1 8.9 0.0 2.6 2 1 0 2 2 2 0 Amidohydrolase MSP1_C PF07462.11 KPI87696.1 - 1.2 7.8 2.0 1.6 7.4 2.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Jnk-SapK_ap_N PF09744.9 KPI87697.1 - 0.033 14.4 1.1 0.041 14.1 1.1 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 XRN_N PF03159.18 KPI87701.1 - 3.5e-27 95.4 0.0 5e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XPG_N PF00752.17 KPI87701.1 - 0.059 13.9 0.0 0.47 10.9 0.0 2.4 2 1 0 2 2 2 0 XPG N-terminal domain Acyl-CoA_dh_1 PF00441.24 KPI87702.1 - 4.6e-40 137.3 2.1 7.2e-40 136.6 2.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KPI87702.1 - 6.5e-28 97.7 0.0 3.6e-27 95.3 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KPI87702.1 - 4.2e-23 81.4 0.1 8.5e-23 80.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KPI87702.1 - 2.6e-19 69.8 0.5 5.7e-19 68.7 0.5 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 KPI87702.1 - 0.024 15.2 0.0 0.041 14.4 0.0 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal DUF1295 PF06966.12 KPI87703.1 - 1.7e-28 99.7 11.4 2.5e-28 99.2 11.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF3043 PF11241.8 KPI87703.1 - 0.99 9.4 2.4 4 7.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) TraX PF05857.11 KPI87703.1 - 7.4 6.6 14.4 1.9 8.5 8.8 2.3 1 1 0 2 2 2 0 TraX protein Aldo_ket_red PF00248.21 KPI87704.1 - 3e-51 174.4 0.0 1.1e-48 165.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family zf-MIZ PF02891.20 KPI87705.1 - 1.6e-10 40.6 0.2 7e-09 35.3 0.0 2.5 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KPI87705.1 - 0.097 12.5 0.1 0.21 11.4 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Methyltr_RsmB-F PF01189.17 KPI87707.1 - 7e-38 130.3 0.0 1.7e-34 119.2 0.0 2.2 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KPI87707.1 - 2e-05 24.8 0.0 5.5e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase TPR_19 PF14559.6 KPI87708.1 - 1.6e-18 66.9 23.3 8.7e-05 22.9 1.7 8.8 7 3 3 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87708.1 - 1.7e-15 56.4 25.0 0.0016 19.1 0.0 8.7 7 2 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI87708.1 - 1.1e-10 42.0 29.6 0.026 15.2 0.0 8.0 8 1 1 9 9 8 4 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KPI87708.1 - 5.3e-09 35.8 14.7 0.00042 20.0 0.6 5.6 4 1 2 6 6 6 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_2 PF07719.17 KPI87708.1 - 7.3e-07 28.8 27.4 3.9 7.8 0.0 10.9 12 0 0 12 12 12 1 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87708.1 - 7.2e-06 26.2 35.3 0.051 13.9 0.1 9.4 8 2 2 10 10 8 4 Tetratricopeptide repeat TPR_20 PF14561.6 KPI87708.1 - 1.3e-05 25.4 6.2 0.076 13.4 0.9 5.3 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI87708.1 - 3.9e-05 23.8 14.6 0.39 11.0 0.0 5.3 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KPI87708.1 - 0.0014 19.2 12.5 3 8.7 0.0 7.5 9 0 0 9 9 7 1 Tetratricopeptide repeat DUF3808 PF10300.9 KPI87708.1 - 0.0058 15.4 5.2 0.4 9.4 0.2 3.5 3 1 0 4 4 4 2 Protein of unknown function (DUF3808) NatB_MDM20 PF09797.9 KPI87708.1 - 0.0069 15.4 0.2 0.0069 15.4 0.2 2.4 3 0 0 3 3 3 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_17 PF13431.6 KPI87708.1 - 0.0074 16.6 11.5 31 5.2 0.0 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat HemY_N PF07219.13 KPI87708.1 - 0.012 15.8 8.4 1.4 9.2 0.1 5.1 4 0 0 4 4 4 0 HemY protein N-terminus TPR_1 PF00515.28 KPI87708.1 - 0.033 14.0 10.4 37 4.4 0.0 7.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI87708.1 - 0.65 10.2 13.6 9.7 6.4 0.5 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KPI87708.1 - 1 10.2 27.1 24 5.9 0.1 8.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI87708.1 - 2.2 8.3 18.3 6.9 6.7 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat Acyl-CoA_dh_C PF12806.7 KPI87708.1 - 4.9 7.3 11.8 5.2 7.3 0.1 5.3 5 1 1 6 6 6 0 Acetyl-CoA dehydrogenase C-terminal like DUF4586 PF15239.6 KPI87709.1 - 8.1e-55 187.1 10.5 9.6e-55 186.9 10.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF1490 PF07371.12 KPI87709.1 - 0.096 12.8 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1490) Pkinase PF00069.25 KPI87710.1 - 1.2e-64 218.3 0.0 1.8e-64 217.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87710.1 - 1.6e-44 152.1 0.0 2.5e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87710.1 - 1.5e-05 24.5 0.0 2.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI87710.1 - 0.00063 18.6 1.7 0.01 14.7 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KPI87710.1 - 0.075 12.9 4.4 1.1 9.1 0.0 2.9 2 1 0 3 3 3 0 Phosphotransferase enzyme family DUF3987 PF13148.6 KPI87710.1 - 0.51 9.3 11.6 0.85 8.6 11.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Ndc1_Nup PF09531.10 KPI87710.1 - 2.1 6.9 6.7 2.9 6.5 6.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PcfK PF14058.6 KPI87710.1 - 2.2 8.6 9.8 7.2 6.9 9.8 1.9 1 0 0 1 1 1 0 PcfK-like protein DCX PF03607.17 KPI87712.1 - 4.8e-08 33.0 0.0 0.00039 20.5 0.0 2.4 2 0 0 2 2 2 2 Doublecortin KHA PF11834.8 KPI87712.1 - 0.00041 20.4 0.0 0.27 11.4 0.0 2.5 2 0 0 2 2 2 2 KHA, dimerisation domain of potassium ion channel SH3_15 PF18346.1 KPI87712.1 - 0.12 12.7 0.1 0.26 11.6 0.1 1.6 1 0 0 1 1 1 0 Mind bomb SH3 repeat domain PAP_central PF04928.17 KPI87713.1 - 1.7e-12 46.9 0.0 2.1e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 KPI87713.1 - 3.5e-05 23.5 0.0 5.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain DUF1691 PF07950.11 KPI87714.1 - 0.17 12.6 0.0 0.51 11.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1691) Sulfatase_C PF14707.6 KPI87714.1 - 0.91 10.3 3.7 17 6.1 0.0 3.3 3 0 0 3 3 3 0 C-terminal region of aryl-sulfatase Fer4_15 PF13459.6 KPI87714.1 - 5 7.9 6.2 2.3 9.0 2.4 2.5 2 1 0 2 2 2 0 4Fe-4S single cluster domain DUF1515 PF07439.11 KPI87714.1 - 7.7 6.6 7.3 18 5.4 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) DUF3439 PF11921.8 KPI87715.1 - 0.0024 17.8 1.5 0.0036 17.2 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) SAM_1 PF00536.30 KPI87716.1 - 0.00084 19.7 0.0 0.0028 18.0 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KPI87716.1 - 0.001 19.2 0.0 0.016 15.3 0.0 2.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KPI87716.1 - 0.0078 16.2 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain ZapD PF07072.11 KPI87716.1 - 0.014 15.1 10.0 0.82 9.4 3.2 4.1 4 0 0 4 4 4 0 Cell division protein PLU-1 PF08429.11 KPI87716.1 - 2.1 7.4 7.0 27 3.8 0.8 3.7 1 1 1 3 3 3 0 PLU-1-like protein Cnd3 PF12719.7 KPI87718.1 - 3.3e-33 115.2 0.4 2.7e-32 112.2 0.0 2.6 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 KPI87718.1 - 4.4e-10 39.8 8.1 5.1e-05 23.6 0.3 4.7 3 1 2 5 5 5 3 HEAT repeats Cnd1 PF12717.7 KPI87718.1 - 3.6e-07 30.3 0.1 0.014 15.4 0.2 4.2 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KPI87718.1 - 2.7e-06 27.2 4.3 5.5 7.5 0.0 6.1 5 0 0 5 5 5 1 HEAT repeat DUF4125 PF13526.6 KPI87718.1 - 0.076 12.6 0.0 1.8 8.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4125) Ints3 PF10189.9 KPI87718.1 - 0.082 12.2 0.2 0.41 9.9 0.0 2.2 3 0 0 3 3 3 0 Integrator complex subunit 3 ACOX PF01756.19 KPI87718.1 - 0.11 12.0 2.1 0.26 10.8 2.1 1.6 1 0 0 1 1 1 0 Acyl-CoA oxidase HEAT_EZ PF13513.6 KPI87718.1 - 1 9.9 4.3 2.6 8.6 0.0 3.6 4 0 0 4 4 4 0 HEAT-like repeat Helicase_C_2 PF13307.6 KPI87719.1 - 3e-49 167.5 0.0 8.6e-49 166.0 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 KPI87719.1 - 2.6e-43 147.7 0.0 5e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 KPI87719.1 - 0.00038 20.5 0.0 0.088 12.8 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 KPI87719.1 - 0.00051 19.9 0.0 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase HBB PF06777.11 KPI87719.1 - 0.0085 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Helical and beta-bridge domain KfrA_N PF11740.8 KPI87719.1 - 0.43 11.3 4.7 5.9 7.6 0.8 2.7 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Pkinase PF00069.25 KPI87720.1 - 4.2e-62 209.9 0.0 6e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87720.1 - 3.2e-42 144.6 0.0 5.1e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87720.1 - 8.7e-05 22.0 0.0 0.00017 21.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI87720.1 - 0.00017 21.6 0.0 0.2 11.5 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI87720.1 - 0.031 13.1 0.0 0.064 12.0 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 KPI87720.1 - 0.031 13.9 0.0 1 8.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PDEase_I PF00233.19 KPI87721.1 - 1.8e-46 158.8 4.0 1.9e-46 158.7 0.0 2.5 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase FYVE PF01363.21 KPI87721.1 - 4.1e-07 30.0 10.8 1.1e-06 28.7 10.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger Fez1 PF06818.15 KPI87721.1 - 0.0012 19.3 13.2 0.0012 19.3 13.2 6.0 2 2 4 6 6 6 2 Fez1 SHE3 PF17078.5 KPI87721.1 - 0.0078 16.0 6.2 0.0078 16.0 6.2 5.7 2 1 4 6 6 6 1 SWI5-dependent HO expression protein 3 HetR_C PF18460.1 KPI87721.1 - 0.017 15.0 0.9 0.017 15.0 0.9 3.5 3 0 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain DapB_C PF05173.14 KPI87721.1 - 0.76 9.8 4.6 0.49 10.4 1.5 2.4 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus Beta_helix PF13229.6 KPI87724.1 - 9.5e-30 103.5 17.2 9.2e-19 67.8 3.1 2.2 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 KPI87724.1 - 2.1e-15 56.7 0.2 2.7e-15 56.3 0.2 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.7 KPI87724.1 - 6.1e-06 26.2 0.5 0.04 13.8 0.0 2.4 1 1 1 2 2 2 2 Pectate lyase superfamily protein DUF1565 PF07602.11 KPI87724.1 - 0.00011 21.6 0.0 0.00027 20.4 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1565) Pkinase PF00069.25 KPI87725.1 - 5.9e-37 127.5 0.0 1.8e-36 125.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87725.1 - 9.9e-18 64.3 0.0 1.7e-17 63.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI87725.1 - 8.7e-06 25.2 0.0 1.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KPI87725.1 - 0.0028 17.2 0.0 0.0049 16.4 0.0 1.5 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL FTA2 PF13095.6 KPI87725.1 - 0.042 13.5 0.0 0.096 12.3 0.0 1.6 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 HalX PF08663.10 KPI87725.1 - 1.5 9.2 5.7 1.8 8.9 1.5 2.4 2 0 0 2 2 2 0 HalX domain START PF01852.19 KPI87726.1 - 1.1e-29 103.4 0.0 1.8e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 KPI87726.1 - 0.00012 22.1 0.0 0.00069 19.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) Actin PF00022.19 KPI87727.1 - 7.6e-18 64.3 0.0 1.6e-12 46.8 0.0 2.6 2 1 0 2 2 2 2 Actin PAN_2 PF08276.11 KPI87727.1 - 0.086 13.0 0.8 2.7 8.2 0.2 2.4 2 0 0 2 2 2 0 PAN-like domain DUF1127 PF06568.11 KPI87728.1 - 1.9 8.3 8.7 0.14 11.9 3.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) TPR_19 PF14559.6 KPI87729.1 - 9.6e-13 48.5 0.7 0.0013 19.2 0.3 5.8 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI87729.1 - 9.8e-08 32.5 7.7 0.0033 18.0 0.0 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI87729.1 - 7.2e-07 28.9 21.8 0.087 13.0 0.1 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87729.1 - 8.1e-07 29.3 6.7 0.8 10.7 0.9 6.3 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI87729.1 - 7.7e-05 22.8 18.7 0.037 14.3 0.1 5.5 5 1 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KPI87729.1 - 0.017 15.4 13.1 7 7.0 0.1 6.5 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87729.1 - 0.031 14.1 19.7 0.8 9.6 0.7 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87729.1 - 0.034 13.8 2.8 0.21 11.3 0.0 3.0 3 0 0 3 3 3 0 TPR repeat TPR_4 PF07721.14 KPI87729.1 - 0.1 13.3 0.2 3.4 8.6 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI87729.1 - 0.13 12.6 3.9 6 7.3 0.0 4.0 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KPI87729.1 - 0.34 11.6 11.4 2.9 8.7 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 KPI87729.1 - 0.37 11.3 2.5 2 9.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI87729.1 - 0.51 10.4 3.3 4 7.6 0.1 3.3 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 KPI87729.1 - 5.2 7.3 5.9 4.6 7.5 0.0 3.8 4 1 1 5 5 5 0 Tetratricopeptide repeat Trypsin_2 PF13365.6 KPI87730.1 - 0.068 14.1 5.2 0.51 11.2 5.2 2.0 1 1 0 1 1 1 0 Trypsin-like peptidase domain Mito_carr PF00153.27 KPI87731.1 - 1.5e-61 204.4 2.4 3.7e-21 74.9 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein ThrE_2 PF12821.7 KPI87731.1 - 0.0099 16.0 3.9 1.3 9.1 0.1 2.7 3 0 0 3 3 3 2 Threonine/Serine exporter, ThrE Tim17 PF02466.19 KPI87731.1 - 0.021 15.2 4.5 0.077 13.4 1.2 3.1 1 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Acyl_transf_3 PF01757.22 KPI87732.1 - 0.015 14.4 0.4 0.021 13.9 0.4 1.2 1 0 0 1 1 1 0 Acyltransferase family IU_nuc_hydro PF01156.19 KPI87733.1 - 2.3e-43 148.9 0.0 3.1e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LRR_6 PF13516.6 KPI87734.1 - 6.6e-28 94.4 33.2 0.00018 21.3 0.7 12.7 14 0 0 14 14 14 9 Leucine Rich repeat LRR_1 PF00560.33 KPI87734.1 - 7.5e-08 31.9 0.4 22 6.1 0.0 7.7 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_4 PF12799.7 KPI87734.1 - 1.4e-05 25.3 11.0 2.4 8.7 0.5 5.7 4 1 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87734.1 - 0.023 14.4 12.6 8.7 6.2 0.1 6.0 5 3 0 5 5 5 0 Leucine rich repeat DUF4407 PF14362.6 KPI87734.1 - 2.2 7.5 15.9 3.5 6.9 15.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RRM_1 PF00076.22 KPI87736.1 - 1.2e-18 66.6 0.0 1.9e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI87736.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1738 PF08401.11 KPI87737.1 - 0.063 13.4 0.0 1.4 9.0 0.0 2.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1738) TolA_bind_tri PF16331.5 KPI87739.1 - 0.0017 18.4 7.4 0.0018 18.3 2.6 2.8 2 1 0 2 2 2 1 TolA binding protein trimerisation DUF1640 PF07798.11 KPI87739.1 - 0.0032 17.5 11.4 0.0087 16.1 2.3 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1640) SHE3 PF17078.5 KPI87739.1 - 0.0084 15.8 6.0 0.0084 15.8 6.0 1.9 1 1 1 2 2 2 1 SWI5-dependent HO expression protein 3 SNAPc19 PF15497.6 KPI87739.1 - 0.023 15.1 2.9 0.089 13.3 2.9 1.9 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 DUF3502 PF12010.8 KPI87739.1 - 0.034 14.8 1.3 0.12 13.0 1.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3502) DUF2797 PF10977.8 KPI87739.1 - 0.067 13.1 7.9 0.097 12.6 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) TPR_MLP1_2 PF07926.12 KPI87739.1 - 0.12 12.5 32.3 0.17 11.9 4.2 3.1 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Peptidase_S39 PF02122.15 KPI87739.1 - 0.27 10.7 1.7 4 6.9 0.4 2.3 2 0 0 2 2 2 0 Peptidase S39 DUF2894 PF11445.8 KPI87739.1 - 0.27 11.7 16.3 0.076 13.5 12.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2894) DUF5339 PF17274.2 KPI87739.1 - 0.58 11.1 11.7 0.83 10.6 0.3 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5339) DUF3584 PF12128.8 KPI87739.1 - 0.88 7.0 19.9 1.3 6.4 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HALZ PF02183.18 KPI87739.1 - 1.4 9.2 9.0 7.5 6.9 0.2 3.8 3 1 0 3 3 3 0 Homeobox associated leucine zipper NPV_P10 PF05531.12 KPI87739.1 - 1.4 9.4 3.6 2.9 8.4 0.9 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Flg_hook PF02120.16 KPI87739.1 - 2.1 8.3 8.9 6.1 6.8 4.4 2.8 2 1 0 2 2 2 0 Flagellar hook-length control protein FliK AIP3 PF03915.13 KPI87739.1 - 2.5 7.1 12.4 4.2 6.3 12.4 1.4 1 1 0 1 1 1 0 Actin interacting protein 3 BshC PF10079.9 KPI87739.1 - 2.6 6.7 10.8 0.99 8.1 7.8 1.6 1 1 0 1 1 1 0 Bacillithiol biosynthesis BshC CP12 PF02672.15 KPI87739.1 - 7.3 7.4 13.2 0.65 10.8 6.3 2.7 2 1 0 2 2 2 0 CP12 domain OpuAC PF04069.12 KPI87740.1 - 0.07 12.7 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system MTHFR PF02219.17 KPI87741.1 - 3.2e-57 194.1 0.0 2.6e-35 122.2 0.0 2.4 1 1 1 2 2 2 2 Methylenetetrahydrofolate reductase Metallophos PF00149.28 KPI87742.1 - 2.3e-15 57.7 0.0 3.4e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 2OG-FeII_Oxy_2 PF13532.6 KPI87743.1 - 2.3e-07 31.2 0.0 3.8e-07 30.5 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KPI87743.1 - 0.00087 19.7 0.0 0.0016 18.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4776 PF16003.5 KPI87743.1 - 0.099 11.6 2.4 0.15 11.0 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) PMM PF03332.13 KPI87744.1 - 1.4e-98 329.0 0.5 1.6e-98 328.8 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 KPI87744.1 - 2.7e-08 33.9 0.0 6.1e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI87744.1 - 0.00037 20.1 0.0 0.18 11.3 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase FliG_N PF14842.6 KPI87744.1 - 0.044 14.3 0.0 0.079 13.5 0.0 1.3 1 0 0 1 1 1 0 FliG N-terminal domain TLD PF07534.16 KPI87745.1 - 1.7e-20 73.7 0.0 1e-19 71.1 0.0 1.9 1 1 0 1 1 1 1 TLD MutS_V PF00488.21 KPI87746.1 - 3.2e-54 183.8 0.5 1.3e-45 155.8 0.3 2.4 2 0 0 2 2 2 2 MutS domain V MutS_I PF01624.20 KPI87746.1 - 8.5e-32 109.7 0.0 2.7e-31 108.1 0.0 1.9 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 KPI87746.1 - 6.3e-27 95.0 0.0 1.5e-26 93.8 0.0 1.7 1 0 0 1 1 1 1 MutS domain III AAA_29 PF13555.6 KPI87746.1 - 0.012 15.3 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KPI87746.1 - 0.027 15.0 0.1 0.07 13.6 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 KPI87746.1 - 0.062 12.9 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KPI87746.1 - 0.16 12.1 0.1 1.5 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF4976 PF16347.5 KPI87746.1 - 0.18 12.1 0.5 0.4 11.0 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) DUF4407 PF14362.6 KPI87747.1 - 0.0074 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) TMEM100 PF16311.5 KPI87748.1 - 0.22 11.1 2.4 0.23 11.1 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 100 COX2_TM PF02790.15 KPI87748.1 - 1.5 9.1 3.9 1.3 9.2 0.3 2.5 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain Amastin PF07344.11 KPI87748.1 - 9 6.1 14.7 8.3 6.2 12.4 2.0 2 1 0 2 2 2 0 Amastin surface glycoprotein zf-C3HC4 PF00097.25 KPI87749.1 - 7.4e-11 41.7 5.6 1.1e-10 41.2 5.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KPI87749.1 - 1.9e-10 40.4 3.3 2.7e-10 40.0 3.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI87749.1 - 5.1e-09 36.3 9.1 7.7e-09 35.8 9.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI87749.1 - 7.1e-09 35.4 8.2 1.1e-08 34.8 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI87749.1 - 1.5e-08 34.5 5.0 1.5e-08 34.5 2.9 2.0 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KPI87749.1 - 1.9e-08 34.1 5.6 3e-08 33.4 5.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KPI87749.1 - 2.8e-07 30.6 7.2 4.3e-07 30.0 7.2 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KPI87749.1 - 8.5e-06 25.6 5.0 1.4e-05 24.9 5.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KPI87749.1 - 0.00096 19.2 2.0 0.0017 18.4 2.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KPI87749.1 - 0.0017 18.6 9.8 0.0042 17.3 9.8 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain Baculo_IE-1 PF05290.11 KPI87749.1 - 0.0024 17.8 1.4 0.0037 17.2 1.4 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) DUF5401 PF17380.2 KPI87749.1 - 0.014 13.5 0.6 0.019 13.0 0.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) zf-RING_6 PF14835.6 KPI87749.1 - 0.023 14.6 4.4 0.043 13.7 4.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF4655 PF15548.6 KPI87749.1 - 0.031 13.3 5.2 0.045 12.7 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4655) Ctr PF04145.15 KPI87749.1 - 0.098 13.3 0.0 0.89 10.2 0.0 2.0 2 0 0 2 2 2 0 Ctr copper transporter family zf-RING_11 PF17123.5 KPI87749.1 - 0.13 12.1 6.0 0.077 12.8 2.8 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 KPI87749.1 - 0.14 11.9 4.7 0.26 11.1 4.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 KPI87749.1 - 0.18 11.5 5.4 0.29 10.8 5.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type IBR PF01485.21 KPI87749.1 - 0.25 11.6 7.5 0.19 12.0 5.7 1.7 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_10 PF16685.5 KPI87749.1 - 0.33 11.1 3.9 0.58 10.3 3.9 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Ribosomal_L37ae PF01780.19 KPI87750.1 - 2.3e-36 123.7 4.3 2.6e-36 123.6 4.3 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family C1_1 PF00130.22 KPI87750.1 - 0.0027 17.6 2.0 0.0039 17.1 2.0 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_13 PF17977.1 KPI87750.1 - 0.047 13.8 1.0 0.066 13.4 1.0 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 KPI87750.1 - 0.11 12.5 3.3 0.19 11.8 3.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain NOB1_Zn_bind PF08772.11 KPI87750.1 - 0.19 11.9 3.4 0.62 10.3 0.4 2.3 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-HIT PF04438.16 KPI87750.1 - 0.23 11.4 2.4 0.32 10.9 0.5 1.9 2 0 0 2 2 2 0 HIT zinc finger DNA_photolyase PF00875.18 KPI87751.1 - 0.0031 17.6 0.4 0.0076 16.3 0.4 1.6 1 0 0 1 1 1 1 DNA photolyase Spectrin PF00435.21 KPI87751.1 - 0.0084 16.6 4.4 5.8 7.5 0.5 3.9 3 0 0 3 3 3 1 Spectrin repeat Longin PF13774.6 KPI87751.1 - 0.019 15.0 0.0 0.13 12.3 0.0 2.3 2 0 0 2 2 2 0 Regulated-SNARE-like domain bZIP_2 PF07716.15 KPI87751.1 - 0.4 10.8 3.7 1.9 8.6 0.3 3.0 2 0 0 2 2 2 0 Basic region leucine zipper PYC_OADA PF02436.18 KPI87751.1 - 0.48 10.1 2.6 1.9 8.2 0.0 2.5 2 1 0 2 2 2 0 Conserved carboxylase domain ZapB PF06005.12 KPI87751.1 - 1.1 9.8 4.5 1.8 9.0 0.9 3.1 3 0 0 3 3 3 0 Cell division protein ZapB DUF4407 PF14362.6 KPI87751.1 - 3.1 7.1 14.6 3.6 6.9 0.1 2.7 2 1 0 3 3 3 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 KPI87751.1 - 5.6 7.0 11.7 0.31 11.1 0.9 2.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 KPI87752.1 - 1.1e-55 188.1 31.2 1.1e-55 188.1 31.2 3.5 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding FTHFS PF01268.19 KPI87752.1 - 0.011 14.0 0.0 0.021 13.1 0.0 1.4 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase DUF1616 PF07760.11 KPI87752.1 - 8.9 5.6 8.4 1.2 8.5 2.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1616) DUF305 PF03713.13 KPI87754.1 - 0.081 13.1 4.9 0.63 10.2 0.9 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF305) ArAE_2_N PF10337.9 KPI87755.1 - 0.013 14.6 0.5 0.019 14.0 0.5 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal CBF PF03914.17 KPI87756.1 - 3.3e-28 98.9 0.2 3.3e-28 98.9 0.2 2.4 2 1 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.11 KPI87756.1 - 4.4e-06 27.0 0.1 1.6e-05 25.2 0.1 2.0 1 0 0 1 1 1 1 Nucleolar complex-associated protein DNA_pol_phi PF04931.13 KPI87756.1 - 0.007 14.5 0.4 0.007 14.5 0.4 2.4 1 1 2 3 3 3 1 DNA polymerase phi DUF2773 PF10971.8 KPI87756.1 - 0.026 14.7 1.3 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) RNA_pol_Rpc82 PF05645.13 KPI87756.1 - 0.23 11.2 3.8 0.44 10.3 3.8 1.7 1 1 0 1 1 1 0 RNA polymerase III subunit RPC82 MVP_shoulder PF11978.8 KPI87757.1 - 9.4e-47 157.9 0.0 1.6e-46 157.1 0.0 1.4 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.18 KPI87757.1 - 3.1e-35 120.1 0.0 2.3e-11 43.7 0.0 5.7 5 0 0 5 5 5 4 Major Vault Protein repeat domain Vault_3 PF17795.1 KPI87757.1 - 1.1e-18 67.0 0.1 1e-16 60.7 0.1 3.4 2 1 0 2 2 2 1 Major Vault Protein Repeat domain Vault_4 PF17796.1 KPI87757.1 - 1.1e-15 57.5 0.2 1.7e-14 53.6 0.0 3.1 4 0 0 4 4 4 1 Major Vault Protein repeat domain Vault_2 PF17794.1 KPI87757.1 - 1.6e-14 54.0 0.3 1.3e-10 41.5 0.0 3.5 3 0 0 3 3 3 2 Major Vault Protein repeat domain Ribosomal_S5_C PF03719.15 KPI87758.1 - 3.3e-11 42.5 0.2 5.6e-11 41.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KPI87758.1 - 5.5e-06 26.3 0.1 1e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF1918 PF08940.11 KPI87758.1 - 0.13 11.9 0.0 0.56 9.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) DEAD PF00270.29 KPI87759.1 - 1.2e-47 161.9 0.1 2e-46 157.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI87759.1 - 4e-28 98.0 0.2 4.4e-27 94.6 0.0 2.7 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KPI87759.1 - 0.00019 20.7 0.2 0.00054 19.2 0.0 1.7 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 KPI87759.1 - 0.00028 20.9 0.0 0.0012 18.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KPI87760.1 - 3.6e-42 144.1 0.0 6.7e-42 143.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI87760.1 - 1.5e-22 80.1 0.1 8.7e-22 77.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KPI87760.1 - 4.2e-16 58.9 0.1 1e-15 57.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Stimulus_sens_1 PF13756.6 KPI87761.1 - 0.43 11.2 5.2 1.4 9.5 0.1 3.7 4 0 0 4 4 4 0 Stimulus-sensing domain Ras PF00071.22 KPI87762.1 - 1.7e-13 50.5 0.0 2.7e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI87762.1 - 1.3e-08 35.0 0.0 3.1e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI87762.1 - 0.084 12.3 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Smg8_Smg9 PF10220.9 KPI87762.1 - 1 7.6 4.2 1.7 6.9 4.2 1.2 1 0 0 1 1 1 0 Smg8_Smg9 MORN PF02493.20 KPI87763.1 - 1.2e-52 172.7 81.2 1.7e-07 30.7 0.5 18.5 19 0 0 19 19 19 16 MORN repeat DUF3048_C PF17479.2 KPI87763.1 - 0.87 10.0 6.9 2.2 8.7 0.1 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain DUF2362 PF10154.9 KPI87764.1 - 0.2 10.6 0.8 0.32 9.9 0.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) NAP PF00956.18 KPI87764.1 - 0.26 10.4 0.2 0.42 9.7 0.2 1.2 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) XRN_N PF03159.18 KPI87765.1 - 2.1e-85 286.0 0.0 2.1e-85 286.0 0.0 2.7 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KPI87765.1 - 1e-61 209.3 2.1 1e-61 209.3 2.1 3.2 2 2 0 2 2 2 1 Xrn1 helical domain TPR_2 PF07719.17 KPI87766.1 - 1.2e-12 46.9 14.9 0.048 13.8 0.1 9.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_1 PF00515.28 KPI87766.1 - 1.1e-10 40.9 8.6 0.015 15.1 0.1 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 KPI87766.1 - 7.6e-10 38.8 16.3 0.00081 19.5 0.1 5.0 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87766.1 - 1.4e-09 38.3 22.4 0.014 15.9 0.3 6.8 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 KPI87766.1 - 1.7e-09 37.4 0.7 0.01 16.2 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87766.1 - 9.6e-05 22.2 6.2 0.064 13.3 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87766.1 - 0.00037 20.1 6.8 0.053 13.2 0.0 5.4 6 1 1 7 7 7 1 TPR repeat TPR_8 PF13181.6 KPI87766.1 - 0.00082 19.4 5.8 24 5.5 0.1 7.3 7 1 2 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI87766.1 - 0.0033 17.7 15.4 2.9 8.3 1.1 5.6 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 KPI87766.1 - 0.0095 16.2 4.1 0.22 11.9 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 KPI87766.1 - 0.19 12.5 7.9 7.4 7.5 0.1 5.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 KPI87766.1 - 2.3 7.3 10.7 0.96 8.6 0.1 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat Aldedh PF00171.22 KPI87768.1 - 5.2e-165 549.4 0.0 5.8e-165 549.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TetR_C_18 PF17923.1 KPI87768.1 - 0.041 14.4 0.1 0.21 12.1 0.0 2.2 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain YbaB_DNA_bd PF02575.16 KPI87770.1 - 1.1e-06 28.8 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family HIF-1 PF11413.8 KPI87770.1 - 0.033 13.6 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Hypoxia-inducible factor-1 DUF5538 PF17692.1 KPI87770.1 - 0.13 12.3 0.7 0.49 10.5 0.0 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5538) MMR_HSR1 PF01926.23 KPI87771.1 - 5.3e-16 58.7 0.0 1.3e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KPI87771.1 - 6.6e-09 36.0 0.0 1.9e-06 28.0 0.2 2.5 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 KPI87771.1 - 4.3e-05 23.1 0.0 0.00027 20.6 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KPI87771.1 - 7.5e-05 22.2 0.1 0.00029 20.2 0.1 2.0 1 1 0 1 1 1 1 AIG1 family Septin PF00735.18 KPI87771.1 - 0.00099 18.5 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 KPI87771.1 - 0.0015 18.4 0.0 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 KPI87771.1 - 0.0023 17.3 0.0 0.0048 16.3 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KPI87771.1 - 0.028 14.6 0.0 0.074 13.3 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KPI87771.1 - 0.15 11.6 0.0 0.36 10.4 0.0 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 KPI87771.1 - 0.15 11.6 0.0 6.8 6.2 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 KPI87771.1 - 0.16 12.5 0.0 0.6 10.6 0.0 2.0 1 0 0 1 1 1 0 ABC transporter TssO PF17561.2 KPI87772.1 - 0.54 10.3 0.0 0.54 10.3 0.0 3.0 3 1 0 3 3 3 0 Type VI secretion system, TssO Rpn9_C PF18261.1 KPI87772.1 - 6.9 6.4 7.3 0.24 11.0 0.2 2.3 3 0 0 3 3 3 0 Rpn9 C-terminal helix Torus PF16131.5 KPI87773.1 - 0.0068 17.1 0.3 6.9 7.4 0.0 2.5 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 KPI87773.1 - 0.0093 16.0 11.0 0.02 14.9 1.1 2.6 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 KPI87774.1 - 4.6e-06 26.4 5.0 9.4e-05 22.2 0.7 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI87774.1 - 0.00057 19.9 13.2 0.047 13.8 4.0 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 KPI87774.1 - 0.0053 16.5 9.5 0.075 12.9 1.6 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 KPI87774.1 - 0.01 16.6 5.0 0.057 14.1 0.3 2.7 2 0 0 2 2 2 1 Torus domain FAD_binding_6 PF00970.24 KPI87776.1 - 1.8e-25 89.1 0.0 2.8e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KPI87776.1 - 4.3e-24 85.3 0.0 6.2e-24 84.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KPI87776.1 - 0.0029 17.7 0.3 0.012 15.7 0.1 2.0 2 1 0 2 2 2 1 Ferric reductase NAD binding domain DUF905 PF06006.12 KPI87776.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) NAD_binding_1 PF00175.21 KPI87777.1 - 1e-25 90.4 0.0 1.6e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KPI87777.1 - 1.6e-19 70.1 0.0 2.9e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KPI87777.1 - 9.5e-06 25.8 0.0 7.5e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain SUI1 PF01253.22 KPI87778.1 - 2.2e-11 44.1 0.0 5.2e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 KPI87778.1 - 0.0027 18.3 0.0 0.009 16.7 0.0 2.0 1 0 0 1 1 1 1 Pre-PUA-like domain zinc_ribbon_10 PF10058.9 KPI87779.1 - 2e-05 24.2 13.6 4.7e-05 23.0 0.2 3.5 3 1 0 3 3 3 2 Predicted integral membrane zinc-ribbon metal-binding protein Zn_Tnp_IS1595 PF12760.7 KPI87779.1 - 0.013 15.4 1.4 0.013 15.4 1.4 3.4 2 1 1 4 4 4 0 Transposase zinc-ribbon domain MitMem_reg PF13012.6 KPI87779.1 - 0.024 15.0 0.5 0.086 13.3 0.3 2.0 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function zf-CRD PF17979.1 KPI87779.1 - 0.032 14.4 4.3 0.032 14.4 4.3 2.9 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions Rep_fac-A_C PF08646.10 KPI87779.1 - 0.77 9.5 5.5 0.65 9.7 3.7 1.9 1 1 0 1 1 1 0 Replication factor-A C terminal domain DZR PF12773.7 KPI87779.1 - 2.1 8.5 19.2 3.1 7.9 5.3 3.9 1 1 2 3 3 3 0 Double zinc ribbon Cytochrom_c3_2 PF14537.6 KPI87779.1 - 2.3 8.8 17.7 0.18 12.3 4.1 2.8 2 1 2 4 4 4 0 Cytochrome c3 CCDC50_N PF15295.6 KPI87779.1 - 2.7 8.2 12.7 2.5 8.3 9.7 2.2 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus RNA_POL_M_15KD PF02150.16 KPI87779.1 - 3.6 7.5 12.0 30 4.6 0.3 3.9 3 1 1 4 4 4 0 RNA polymerases M/15 Kd subunit PHD PF00628.29 KPI87779.1 - 5.6 6.9 18.2 2.6 8.0 3.8 4.2 2 1 2 4 4 4 0 PHD-finger Pkinase PF00069.25 KPI87780.1 - 8.4e-65 218.7 0.0 1.1e-64 218.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87780.1 - 1.4e-34 119.6 0.0 1.8e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87780.1 - 5.4e-05 22.6 0.0 8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI87780.1 - 0.0078 15.0 0.1 0.029 13.1 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KPI87780.1 - 0.014 14.8 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI87780.1 - 0.044 13.7 0.0 1.5 8.7 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI87780.1 - 0.11 11.4 0.0 0.25 10.2 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Ribosomal_L22 PF00237.19 KPI87781.1 - 9.9e-14 51.4 0.0 1.4e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Prp18 PF02840.15 KPI87785.1 - 5.5e-11 42.7 0.1 1e-10 41.9 0.1 1.5 1 0 0 1 1 1 1 Prp18 domain Arrestin_N PF00339.29 KPI87786.1 - 1.6e-13 50.9 0.0 2.6e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KPI87786.1 - 7.4e-07 29.7 0.0 0.03 14.8 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 KPI87786.1 - 0.039 13.7 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 Arrestin_N terminal like EF-hand_1 PF00036.32 KPI87789.1 - 6.7e-14 50.3 2.0 0.00012 21.4 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KPI87789.1 - 5e-13 47.8 2.2 0.00065 19.4 0.0 4.6 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 KPI87789.1 - 2.6e-10 40.6 0.1 0.019 15.4 0.0 4.1 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KPI87789.1 - 4.7e-06 26.3 2.1 0.0091 15.8 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KPI87789.1 - 1.9e-05 24.0 0.5 0.017 14.6 0.0 3.5 3 0 0 3 3 3 2 EF hand RRM_1 PF00076.22 KPI87790.1 - 1.4e-11 44.0 1.5 4.9e-06 26.3 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI87790.1 - 0.0045 16.6 0.0 0.0089 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOR PF05036.13 KPI87790.1 - 0.074 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Sporulation related domain DBINO PF13892.6 KPI87790.1 - 0.16 12.4 6.7 0.23 11.8 6.7 1.2 1 0 0 1 1 1 0 DNA-binding domain ISG65-75 PF11727.8 KPI87790.1 - 0.62 9.3 9.0 1.1 8.4 8.2 1.7 1 1 1 2 2 2 0 Invariant surface glycoprotein IGR PF09597.10 KPI87791.1 - 1.6e-06 28.1 0.0 3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 IGR protein motif BRE1 PF08647.11 KPI87792.1 - 7.3e-12 45.2 9.9 7.3e-12 45.2 9.9 11.3 2 2 10 13 13 13 5 BRE1 E3 ubiquitin ligase DUF4094 PF13334.6 KPI87792.1 - 0.006 17.0 5.9 0.006 17.0 5.9 8.0 5 3 4 9 9 9 1 Domain of unknown function (DUF4094) DUF745 PF05335.13 KPI87792.1 - 0.0083 15.9 15.8 0.0083 15.9 15.8 7.3 1 1 7 9 9 9 1 Protein of unknown function (DUF745) TMF_TATA_bd PF12325.8 KPI87792.1 - 0.023 14.9 2.0 0.023 14.9 2.0 11.0 3 3 8 11 11 11 0 TATA element modulatory factor 1 TATA binding AAA_13 PF13166.6 KPI87792.1 - 0.13 10.9 107.3 0.011 14.5 15.9 6.0 1 1 4 6 6 6 0 AAA domain APG6_N PF17675.1 KPI87792.1 - 2.3 8.8 148.3 0.37 11.3 15.2 9.3 2 2 6 8 8 8 0 Apg6 coiled-coil region Nkap_C PF06047.11 KPI87794.1 - 3.9e-14 52.6 0.6 3.9e-14 52.6 0.6 1.9 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain FYVE PF01363.21 KPI87796.1 - 0.05 13.8 15.0 0.21 11.8 15.0 1.8 1 1 0 1 1 1 0 FYVE zinc finger RtcB PF01139.17 KPI87797.1 - 7.8e-111 371.2 0.0 1.3e-110 370.5 0.0 1.3 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB NifU PF01106.17 KPI87799.1 - 2.1e-21 75.8 0.0 5.7e-21 74.5 0.0 1.8 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 KPI87799.1 - 5.1e-13 48.9 0.0 3.6e-11 43.0 0.0 2.4 2 0 0 2 2 2 2 Scaffold protein Nfu/NifU N terminal LRR_4 PF12799.7 KPI87801.1 - 3.6e-21 74.9 7.2 9.5e-05 22.7 0.1 10.1 8 2 3 11 11 11 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87801.1 - 5.3e-11 42.1 9.8 0.0066 16.2 0.0 7.9 7 2 2 9 9 9 4 Leucine rich repeat ADH_N PF08240.12 KPI87802.1 - 7.2e-25 87.0 0.2 2.9e-24 85.0 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI87802.1 - 1.5e-16 60.5 0.0 2.5e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KPI87802.1 - 5.8e-05 24.2 0.0 0.00011 23.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SET PF00856.28 KPI87804.1 - 3.4e-07 30.8 0.0 1.2e-06 29.0 0.0 2.0 1 1 0 1 1 1 1 SET domain TolA PF06519.11 KPI87804.1 - 0.22 11.8 0.3 8 6.7 0.2 2.7 2 0 0 2 2 2 0 TolA C-terminal Tox-GHH PF15636.6 KPI87806.1 - 0.053 13.5 1.2 0.17 11.9 1.2 1.8 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin Creatininase PF02633.14 KPI87807.1 - 0.0049 16.4 0.2 0.0049 16.4 0.2 1.8 2 0 0 2 2 2 1 Creatinine amidohydrolase Mhr1 PF12829.7 KPI87807.1 - 0.15 12.2 0.1 0.37 10.9 0.1 1.6 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination FAD_binding_7 PF03441.14 KPI87808.1 - 5.3e-68 228.5 1.6 8.8e-68 227.8 1.6 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KPI87808.1 - 2.1e-29 102.6 0.0 3.6e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase DUF4502 PF14950.6 KPI87808.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) DUF3523 PF12037.8 KPI87809.1 - 0.0019 17.6 1.5 0.003 17.0 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) HTH_15 PF12324.8 KPI87812.1 - 0.011 15.6 0.2 0.041 13.8 0.2 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase SBF PF01758.16 KPI87814.1 - 0.041 13.6 0.3 0.055 13.1 0.3 1.1 1 0 0 1 1 1 0 Sodium Bile acid symporter family MutS_V PF00488.21 KPI87815.1 - 4.8e-72 241.9 0.1 8.5e-72 241.1 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KPI87815.1 - 4.6e-28 98.7 1.9 1.5e-27 97.0 1.9 1.9 1 1 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 KPI87815.1 - 1.7e-17 63.5 1.7 4.4e-17 62.2 1.7 1.8 1 0 0 1 1 1 1 MutS family domain IV MnmE_helical PF12631.7 KPI87815.1 - 0.0054 16.9 3.9 0.0064 16.7 1.8 2.1 2 0 0 2 2 2 1 MnmE helical domain Glyco_trans_4_5 PF16994.5 KPI87815.1 - 0.1 12.2 0.6 11 5.5 0.1 2.6 2 0 0 2 2 2 0 Glycosyl-transferase family 4 AAA_29 PF13555.6 KPI87815.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ApoB100_C PF12491.8 KPI87815.1 - 0.75 9.8 3.3 0.9 9.5 0.4 2.4 2 0 0 2 2 2 0 Apolipoprotein B100 C terminal DUF4407 PF14362.6 KPI87815.1 - 3.5 6.9 7.9 0.095 12.0 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Hydrolase_4 PF12146.8 KPI87816.1 - 1.2e-16 60.7 0.4 1.8e-11 43.8 0.6 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI87816.1 - 6.4e-11 42.4 4.5 3.5e-08 33.4 0.7 3.2 3 1 1 4 4 4 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KPI87816.1 - 6.9e-05 23.5 1.7 0.00017 22.3 1.7 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 KPI87816.1 - 0.00021 21.1 0.2 0.0095 15.8 0.2 2.3 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KPI87816.1 - 0.0012 18.4 0.0 0.016 14.7 0.0 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 KPI87816.1 - 0.0045 16.7 0.0 0.0078 15.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 KPI87816.1 - 0.015 15.2 1.3 0.016 15.1 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold BLACT_WH PF17778.1 KPI87816.1 - 0.034 14.1 0.2 0.089 12.8 0.2 1.7 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain His_Phos_1 PF00300.22 KPI87816.1 - 0.068 12.9 0.4 0.86 9.3 0.1 2.1 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) WD40 PF00400.32 KPI87819.1 - 3.1e-09 37.3 4.9 1.8e-05 25.4 0.1 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI87819.1 - 0.054 13.8 0.0 10 6.5 0.0 3.3 2 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain HSP90 PF00183.18 KPI87820.1 - 3.8e-226 752.0 27.9 4.8e-226 751.7 27.9 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KPI87820.1 - 1.7e-17 63.9 0.1 3.4e-17 63.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KPI87820.1 - 8.9e-11 41.8 0.1 2.5e-10 40.3 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ABC_tran PF00005.27 KPI87821.1 - 3.3e-46 157.2 0.2 2.6e-21 76.6 0.0 3.5 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 KPI87821.1 - 3.3e-17 63.3 1.1 0.00012 22.0 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI87821.1 - 3.5e-12 46.3 0.1 3e-05 23.6 0.0 4.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KPI87821.1 - 4.9e-08 33.1 0.1 0.0075 16.2 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KPI87821.1 - 2e-07 30.6 0.2 0.012 15.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 KPI87821.1 - 3.3e-06 27.1 0.0 0.33 10.6 0.0 4.1 4 1 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 KPI87821.1 - 0.00015 22.0 0.0 0.27 11.5 0.0 2.9 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KPI87821.1 - 0.00063 19.8 0.1 0.23 11.6 0.1 3.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 KPI87821.1 - 0.00097 19.4 3.0 0.1 12.8 0.1 2.9 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 KPI87821.1 - 0.0012 19.3 4.4 2.1 8.7 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.22 KPI87821.1 - 0.0013 19.1 0.0 1.2 9.5 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 KPI87821.1 - 0.0032 17.6 0.0 1.2 9.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 KPI87821.1 - 0.0035 17.4 0.1 1.9 8.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 KPI87821.1 - 0.0044 16.8 2.0 0.8 9.4 0.0 3.6 2 1 1 3 3 3 1 AAA domain AAA_23 PF13476.6 KPI87821.1 - 0.0066 17.0 0.2 0.085 13.3 0.0 4.8 6 0 0 6 6 4 2 AAA domain Nbl1_Borealin_N PF10444.9 KPI87821.1 - 0.0069 16.0 0.4 0.025 14.2 0.4 1.9 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal AAA PF00004.29 KPI87821.1 - 0.0073 16.7 0.1 3.7 8.0 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KPI87821.1 - 0.0077 16.3 0.1 2.8 8.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 KPI87821.1 - 0.0083 16.3 0.5 0.39 11.0 0.1 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 KPI87821.1 - 0.035 14.0 0.0 10 6.0 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 KPI87821.1 - 0.078 12.9 0.0 2.2 8.2 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 KPI87821.1 - 0.096 12.2 0.1 15 5.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KPI87821.1 - 0.14 11.6 0.2 5.7 6.3 0.1 2.6 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KPI87821.1 - 0.17 12.4 7.0 2 9.0 0.0 4.2 4 1 1 5 5 5 0 AAA domain Dynamin_N PF00350.23 KPI87821.1 - 6.6 6.8 8.2 27 4.8 0.0 3.7 5 0 0 5 5 5 0 Dynamin family Glyco_tranf_2_3 PF13641.6 KPI87822.1 - 4.4e-06 26.8 0.0 7.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KPI87822.1 - 1.9e-05 24.5 0.0 3.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 LIM_bind PF01803.16 KPI87822.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 LIM-domain binding protein Autophagy_N PF03986.13 KPI87823.1 - 1.2e-24 86.8 0.6 2.1e-24 86.0 0.6 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 KPI87823.1 - 3.1e-17 62.9 3.1 6.9e-17 61.8 3.1 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 KPI87823.1 - 9.2e-11 41.1 0.4 2.1e-10 39.9 0.4 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal DNA_pol_B_thumb PF14791.6 KPI87824.1 - 0.0069 16.5 0.0 0.018 15.2 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase beta thumb Lge1 PF11488.8 KPI87825.1 - 3.8 7.8 6.7 0.66 10.2 0.9 2.5 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Cys_rich_FGFR PF00839.17 KPI87825.1 - 7.9 6.7 14.8 29 4.9 0.1 3.7 2 1 1 3 3 3 0 Cysteine rich repeat Dymeclin PF09742.9 KPI87826.1 - 2.6e-47 161.6 0.0 3.6e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 KPI87826.1 - 0.063 11.4 3.8 0.33 9.0 0.5 2.3 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Trimer_CC PF08954.11 KPI87826.1 - 0.22 11.1 0.3 0.56 9.8 0.3 1.6 1 0 0 1 1 1 0 Trimerisation motif TMEM208_SND2 PF05620.11 KPI87827.1 - 7.9e-29 100.6 0.0 9.1e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 FlgN PF05130.12 KPI87829.1 - 0.21 12.1 4.6 0.095 13.2 1.7 1.9 2 0 0 2 2 2 0 FlgN protein Aldedh PF00171.22 KPI87829.1 - 1.2 7.6 3.0 1.7 7.1 3.0 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family DUF4140 PF13600.6 KPI87829.1 - 8.2 6.9 7.9 18 5.9 0.9 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Jun PF03957.13 KPI87830.1 - 0.31 10.9 4.5 0.44 10.4 4.5 1.1 1 0 0 1 1 1 0 Jun-like transcription factor DUF4707 PF15806.5 KPI87830.1 - 0.75 8.7 3.4 1 8.2 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4707) MPC PF03650.13 KPI87831.1 - 9.1e-16 58.0 0.1 9.1e-16 58.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DHHA2 PF02833.14 KPI87832.1 - 1.3e-17 64.4 0.0 3e-17 63.2 0.1 1.6 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 KPI87832.1 - 1.2e-09 38.3 0.1 2.2e-09 37.4 0.1 1.4 1 0 0 1 1 1 1 DHH family Thoc2 PF11732.8 KPI87832.1 - 0.12 12.5 0.0 0.74 9.9 0.0 2.2 2 0 0 2 2 2 0 Transcription- and export-related complex subunit Cmc1 PF08583.10 KPI87833.1 - 0.00048 20.1 2.9 0.0008 19.4 2.9 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 KPI87833.1 - 0.0098 15.9 3.7 0.021 14.9 3.7 1.5 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 KPI87833.1 - 0.082 13.1 2.0 1.7 8.9 0.2 2.4 1 1 1 2 2 2 0 CHCH domain COX17 PF05051.13 KPI87833.1 - 0.18 12.2 1.5 0.25 11.7 0.1 1.9 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) UCR_hinge PF02320.16 KPI87833.1 - 0.99 9.7 5.1 2.2 8.6 0.4 2.2 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein PseudoU_synth_2 PF00849.22 KPI87834.1 - 4e-20 72.5 0.0 9.6e-20 71.3 0.0 1.6 2 0 0 2 2 2 1 RNA pseudouridylate synthase Thioredoxin PF00085.20 KPI87835.1 - 3.9e-20 71.7 0.1 4.4e-20 71.6 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KPI87835.1 - 1.5e-05 25.4 0.4 0.00012 22.5 0.4 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KPI87835.1 - 0.00033 20.9 0.4 0.048 14.0 0.2 2.1 1 1 1 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 KPI87835.1 - 0.00077 18.9 0.0 0.00085 18.8 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 KPI87835.1 - 0.002 18.0 0.1 0.0026 17.7 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_6 PF13848.6 KPI87835.1 - 0.0097 15.8 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.24 KPI87835.1 - 0.021 15.0 0.4 0.038 14.2 0.4 1.4 1 0 0 1 1 1 0 Glutaredoxin Thioredoxin_7 PF13899.6 KPI87835.1 - 0.024 14.8 0.3 0.034 14.3 0.3 1.4 1 1 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 KPI87835.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Enkurin PF13864.6 KPI87836.1 - 1e-20 74.0 9.6 1e-20 74.0 9.6 1.9 2 0 0 2 2 2 1 Calmodulin-binding DUF2730 PF10805.8 KPI87836.1 - 0.13 12.4 0.4 0.25 11.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Beta_helix PF13229.6 KPI87837.1 - 4.2e-09 36.4 0.0 8.3e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 KPI87837.1 - 0.00017 21.0 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) SNF2_N PF00176.23 KPI87838.1 - 6.7e-38 130.3 0.0 1.9e-37 128.8 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI87838.1 - 2.3e-13 50.4 0.0 5.1e-13 49.3 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI87838.1 - 0.00049 19.9 0.0 0.0017 18.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 KPI87838.1 - 0.0011 19.0 0.0 0.0029 17.7 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 KPI87838.1 - 0.035 13.0 0.0 0.066 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Pro_isomerase PF00160.21 KPI87840.1 - 1.5e-36 126.0 0.0 2.1e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF2673 PF10880.8 KPI87840.1 - 0.12 12.5 0.6 0.55 10.4 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2673) CUE PF02845.16 KPI87841.1 - 2.4e-11 43.1 0.1 0.00052 19.6 0.0 3.6 3 0 0 3 3 3 2 CUE domain DUF1771 PF08590.10 KPI87841.1 - 2.9e-09 37.1 1.6 2.9e-09 37.1 1.6 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 KPI87841.1 - 5.8e-09 36.2 0.8 2.5e-08 34.2 0.8 2.2 1 0 0 1 1 1 1 Smr domain DMA PF03474.14 KPI87841.1 - 7.2e-05 22.3 0.1 0.1 12.2 0.0 2.9 3 0 0 3 3 3 2 DMRTA motif HOIP-UBA PF16678.5 KPI87841.1 - 9.4e-05 22.5 2.7 0.056 13.4 0.3 2.9 2 0 0 2 2 2 2 HOIP UBA domain pair UBA PF00627.31 KPI87841.1 - 0.013 15.4 0.1 0.013 15.4 0.1 3.8 4 0 0 4 4 4 0 UBA/TS-N domain LMWPc PF01451.21 KPI87842.1 - 8.9e-05 22.9 0.1 0.00067 20.1 0.1 2.2 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Voltage_CLC PF00654.20 KPI87844.1 - 1.2e-86 291.2 30.0 1.2e-86 291.2 30.0 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KPI87844.1 - 2e-05 25.0 0.0 0.041 14.3 0.0 2.5 2 0 0 2 2 2 2 CBS domain HHV-5_US34A PF17087.5 KPI87844.1 - 1.6 8.9 9.7 0.92 9.7 1.0 3.2 3 0 0 3 3 3 0 Herpesvirus US34A protein family Argos PF11581.8 KPI87845.1 - 0.11 12.5 0.3 0.25 11.4 0.3 1.5 1 0 0 1 1 1 0 Antagonist of EGFR signalling, Argos LSM PF01423.22 KPI87846.1 - 1e-10 41.1 0.0 1.1e-10 41.0 0.0 1.0 1 0 0 1 1 1 1 LSM domain Par3_HAL_N_term PF12053.8 KPI87848.1 - 0.00057 20.1 0.0 0.0007 19.8 0.0 1.1 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins Glutaredoxin PF00462.24 KPI87851.1 - 5e-17 61.9 0.2 1.2e-16 60.6 0.2 1.7 1 0 0 1 1 1 1 Glutaredoxin TrwC PF08751.11 KPI87851.1 - 0.2 11.1 0.0 0.28 10.7 0.0 1.1 1 0 0 1 1 1 0 TrwC relaxase Glyco_transf_11 PF01531.16 KPI87852.1 - 1.1e-11 44.6 0.8 1.5e-06 27.7 0.0 3.0 3 0 0 3 3 3 3 Glycosyl transferase family 11 Thymidylate_kin PF02223.17 KPI87853.1 - 8.7e-27 94.0 0.0 1.1e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 KPI87853.1 - 8e-05 22.8 2.1 0.00051 20.2 1.7 2.4 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 KPI87853.1 - 0.00012 22.7 0.1 0.00098 19.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI87853.1 - 0.0036 17.6 0.0 0.0085 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI87853.1 - 0.019 15.4 0.3 0.03 14.7 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 KPI87853.1 - 0.02 14.6 1.3 0.033 13.9 0.3 2.0 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.9 KPI87853.1 - 0.02 14.1 0.0 0.038 13.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.6 KPI87853.1 - 0.03 14.6 1.5 0.067 13.4 1.5 1.6 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 KPI87853.1 - 0.046 13.7 0.1 0.096 12.7 0.1 1.7 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 KPI87853.1 - 0.064 13.7 0.0 0.41 11.1 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) 6PF2K PF01591.18 KPI87853.1 - 0.089 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Vps39_2 PF10367.9 KPI87853.1 - 0.097 13.1 0.0 1 9.8 0.0 2.4 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 AAA_26 PF13500.6 KPI87853.1 - 0.13 12.1 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain BSD PF03909.17 KPI87855.1 - 2.1e-07 30.9 0.3 4.9e-07 29.7 0.3 1.7 1 0 0 1 1 1 1 BSD domain DUF5076 PF16826.5 KPI87855.1 - 0.053 13.4 0.1 0.16 11.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5076) Citrate_synt PF00285.21 KPI87855.1 - 1.8 7.6 4.0 4.1 6.4 0.0 2.5 2 1 0 3 3 3 0 Citrate synthase, C-terminal domain OmpH PF03938.14 KPI87856.1 - 0.018 15.4 4.6 0.024 15.0 4.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tox-ODYAM1 PF15642.6 KPI87856.1 - 0.058 12.3 3.9 0.075 12.0 3.9 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus CPSase_L_D2 PF02786.17 KPI87857.1 - 1.4e-75 253.5 0.5 2.3e-75 252.7 0.5 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KPI87857.1 - 2.1e-44 150.5 0.1 7e-44 148.9 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KPI87857.1 - 1e-34 118.9 0.0 4.2e-34 116.9 0.0 2.1 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KPI87857.1 - 5.1e-17 61.5 6.1 5.1e-17 61.5 6.1 2.4 3 0 0 3 3 3 1 Biotin-requiring enzyme ATP-grasp PF02222.22 KPI87857.1 - 2.3e-09 37.0 0.6 7.9e-09 35.3 0.3 1.9 2 0 0 2 2 2 1 ATP-grasp domain PCC_BT PF18140.1 KPI87857.1 - 1.2e-07 32.1 0.0 3.3e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl_2 PF13533.6 KPI87857.1 - 1.3e-06 28.1 0.7 0.0054 16.5 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 KPI87857.1 - 3.8e-06 26.6 0.4 8.3e-06 25.5 0.4 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus HlyD_3 PF13437.6 KPI87857.1 - 5.3e-05 23.9 0.4 0.31 11.8 0.0 3.2 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_D23 PF16576.5 KPI87857.1 - 8.8e-05 21.8 0.7 0.28 10.4 0.1 2.3 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 KPI87857.1 - 9.2e-05 22.5 0.2 0.00016 21.7 0.2 1.5 1 0 0 1 1 1 1 ATP-grasp domain GCV_H PF01597.19 KPI87857.1 - 0.00062 19.6 0.8 0.0015 18.4 0.8 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 KPI87857.1 - 0.0019 18.1 0.4 0.0054 16.7 0.4 1.9 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain ATPgrasp_ST PF14397.6 KPI87857.1 - 0.0089 15.3 0.1 0.025 13.8 0.0 1.7 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp GARS_A PF01071.19 KPI87857.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF3029 PF11230.8 KPI87857.1 - 0.057 11.8 0.0 0.097 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) NQRA PF05896.11 KPI87857.1 - 0.062 12.7 0.8 0.095 12.1 0.8 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GYF PF02213.16 KPI87858.1 - 0.0011 18.6 0.0 0.0021 17.7 0.0 1.3 1 0 0 1 1 1 1 GYF domain Kinesin PF00225.23 KPI87859.1 - 3e-94 315.7 0.0 4e-94 315.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI87859.1 - 1.7e-16 60.5 0.0 2.9e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding BLOC1_2 PF10046.9 KPI87859.1 - 0.026 14.8 1.4 0.061 13.6 1.4 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ABC_tran_Xtn PF12848.7 KPI87859.1 - 0.036 14.1 2.1 0.078 13.0 2.1 1.5 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KPI87859.1 - 0.046 14.1 0.9 0.12 12.8 0.0 2.2 3 0 0 3 3 3 0 AAA ATPase domain Exo_endo_phos PF03372.23 KPI87860.1 - 1.9e-11 43.9 0.1 3.2e-11 43.2 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Shisa PF13908.6 KPI87861.1 - 0.0011 19.2 0.5 0.002 18.4 0.0 1.6 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator MAP17 PF15807.5 KPI87861.1 - 0.0016 18.7 0.0 0.0028 17.9 0.0 1.3 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TMEM52 PF14979.6 KPI87861.1 - 0.029 14.3 0.6 0.056 13.4 0.6 1.4 1 0 0 1 1 1 0 Transmembrane 52 Hum_adeno_E3A PF05393.11 KPI87861.1 - 0.037 14.0 0.9 0.15 12.1 0.9 2.0 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Cadherin_C_2 PF16492.5 KPI87861.1 - 0.053 14.3 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal SIT PF15330.6 KPI87861.1 - 0.059 13.8 0.0 0.059 13.8 0.0 1.6 2 0 0 2 2 1 0 SHP2-interacting transmembrane adaptor protein, SIT WBP-1 PF11669.8 KPI87861.1 - 0.073 13.7 0.5 0.073 13.7 0.5 2.0 2 0 0 2 2 1 0 WW domain-binding protein 1 FAM176 PF14851.6 KPI87861.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 FAM176 family PRIMA1 PF16101.5 KPI87861.1 - 0.12 12.4 1.2 0.27 11.3 1.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EphA2_TM PF14575.6 KPI87861.1 - 0.19 12.7 0.0 0.41 11.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2946 PF11162.8 KPI87861.1 - 0.19 12.4 2.5 0.63 10.7 2.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2946) Prominin PF05478.11 KPI87861.1 - 0.68 7.8 2.5 0.96 7.3 2.5 1.1 1 0 0 1 1 1 0 Prominin Glyco_hydro_63 PF03200.16 KPI87862.1 - 2e-46 158.8 0.6 1.1e-43 149.8 0.6 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 KPI87862.1 - 8.7e-18 65.2 0.2 2.3e-17 63.8 0.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain Prp19 PF08606.11 KPI87863.1 - 9.8 6.2 8.4 5.9 6.9 2.4 2.9 3 0 0 3 3 3 0 Prp19/Pso4-like TipAS PF07739.13 KPI87865.1 - 0.15 12.6 3.0 15 6.1 0.5 2.7 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Sel1 PF08238.12 KPI87865.1 - 0.23 12.2 3.4 1 10.1 0.1 3.5 4 0 0 4 4 4 0 Sel1 repeat Methyltransf_25 PF13649.6 KPI87866.1 - 2.3e-09 37.8 0.1 5.3e-09 36.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI87866.1 - 4.3e-08 33.8 0.0 7.5e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI87866.1 - 8.3e-08 32.2 0.0 1.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI87866.1 - 2.9e-06 27.8 0.1 7.2e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI87866.1 - 0.00022 21.1 0.0 0.0005 19.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KPI87866.1 - 0.037 13.4 0.1 0.058 12.8 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 KPI87866.1 - 0.095 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Kelch_5 PF13854.6 KPI87867.1 - 8.4e-10 38.4 0.3 8.2e-07 28.9 0.0 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KPI87867.1 - 1.3e-08 34.7 0.1 6.4e-06 26.1 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KPI87867.1 - 8.4e-08 32.2 0.1 3.4e-05 24.0 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 KPI87867.1 - 0.00048 20.3 9.5 0.83 10.0 0.0 5.3 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KPI87867.1 - 0.00099 19.0 0.4 0.021 14.8 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 KPI87867.1 - 0.033 13.8 2.1 0.047 13.3 0.1 2.4 3 0 0 3 3 3 0 Kelch motif HhH-GPD PF00730.25 KPI87868.1 - 5.4e-21 75.1 0.0 1.1e-20 74.1 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 KPI87868.1 - 3.2e-11 43.2 0.0 7.3e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 KPI87868.1 - 2.3e-05 24.0 0.2 7.7e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KPI87868.1 - 0.0081 16.8 0.0 0.52 11.0 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 KPI87868.1 - 0.018 15.1 0.0 8.1 6.6 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif Whib PF02467.16 KPI87868.1 - 0.09 13.4 3.8 0.32 11.6 1.2 2.7 2 0 0 2 2 2 0 Transcription factor WhiB HRDC PF00570.23 KPI87868.1 - 0.16 12.0 0.0 0.55 10.3 0.0 1.9 1 0 0 1 1 1 0 HRDC domain Amastin PF07344.11 KPI87869.1 - 1.3e-21 77.0 13.1 1.8e-21 76.6 13.1 1.2 1 0 0 1 1 1 1 Amastin surface glycoprotein UL45 PF05473.12 KPI87869.1 - 0.0084 15.8 0.1 0.0084 15.8 0.1 1.7 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Rhodanese PF00581.20 KPI87870.1 - 2.3e-13 50.6 0.0 3.4e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain DUF2892 PF11127.8 KPI87870.1 - 1.1e-06 28.6 1.3 1.8e-06 27.9 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2892) Cullin PF00888.22 KPI87871.1 - 4e-36 124.8 0.0 1.3e-35 123.1 0.0 1.6 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KPI87871.1 - 4.8e-05 23.3 0.1 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain Penicillinase_R PF03965.16 KPI87871.1 - 0.0035 17.7 0.0 0.013 15.9 0.0 2.0 1 0 0 1 1 1 1 Penicillinase repressor TrmB PF01978.19 KPI87871.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_42 PF06224.12 KPI87871.1 - 0.039 13.5 0.0 0.075 12.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain GDPD PF03009.17 KPI87872.1 - 4.1e-18 66.1 0.0 3.5e-15 56.5 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family UPF0220 PF05255.11 KPI87873.1 - 3.7e-11 42.8 0.6 4.5e-11 42.6 0.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF202 PF02656.15 KPI87873.1 - 2.1 8.8 8.7 3.5 8.1 3.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF202) CEP76-C2 PF15627.6 KPI87874.1 - 4.8e-38 130.2 0.0 9.3e-38 129.3 0.0 1.4 1 0 0 1 1 1 1 CEP76 C2 domain DEAD PF00270.29 KPI87875.1 - 1.4e-45 155.2 0.0 3.3e-45 154.0 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI87875.1 - 8.7e-28 96.9 0.1 5.8e-27 94.2 0.1 2.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI87875.1 - 8.9e-08 32.3 0.0 2.2e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KPI87875.1 - 0.00025 20.4 0.1 0.00038 19.7 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase PhoH PF02562.16 KPI87875.1 - 0.012 15.1 0.3 7.7 5.9 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein T4SS-DNA_transf PF02534.14 KPI87875.1 - 0.013 14.3 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_30 PF13604.6 KPI87875.1 - 0.014 15.2 0.2 0.24 11.1 0.0 2.7 3 0 0 3 3 3 0 AAA domain Sua5_yciO_yrdC PF01300.18 KPI87876.1 - 1e-47 162.0 0.0 1.4e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 KPI87876.1 - 1.6e-12 48.2 0.0 3.2e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding RNA_pol_L_2 PF13656.6 KPI87877.1 - 2.9e-23 81.4 0.0 4.6e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KPI87877.1 - 0.00043 19.6 0.0 0.00077 18.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SecD-TM1 PF13721.6 KPI87877.1 - 0.11 12.9 0.1 2.7 8.5 0.0 2.1 1 1 1 2 2 2 0 SecD export protein N-terminal TM region AMP-binding PF00501.28 KPI87878.1 - 5.6e-30 104.3 0.0 8.4e-30 103.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Ank_4 PF13637.6 KPI87878.1 - 3.3e-15 56.2 0.9 0.00014 22.3 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI87878.1 - 7.7e-15 55.3 0.1 5e-08 33.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI87878.1 - 2.9e-10 39.5 2.9 0.038 14.5 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KPI87878.1 - 1.5e-08 34.8 2.5 0.016 15.5 0.0 4.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KPI87878.1 - 8.5e-07 29.2 9.0 0.042 14.3 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat PP-binding PF00550.25 KPI87878.1 - 0.068 13.5 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Phosphopantetheine attachment site DPCD PF14913.6 KPI87879.1 - 2.2e-63 213.1 0.0 2.5e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 DPCD protein family GRIM-19 PF06212.12 KPI87880.1 - 7.4e-08 32.4 0.0 9.6e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 GRIM-19 protein PPP4R2 PF09184.11 KPI87882.1 - 1.1 8.8 3.1 1.8 8.1 3.1 1.2 1 0 0 1 1 1 0 PPP4R2 Pkinase PF00069.25 KPI87883.1 - 4.4e-59 200.0 0.0 9.8e-59 198.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87883.1 - 2.8e-29 102.2 0.0 5.3e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI87883.1 - 1.5e-05 24.0 0.0 5.6e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KPI87883.1 - 0.0011 18.9 0.1 0.025 14.5 0.1 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI87883.1 - 0.0046 16.3 0.0 0.0071 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 KPI87883.1 - 0.019 14.6 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 KPI87883.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KPI87883.1 - 0.2 11.1 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL SUIM_assoc PF16619.5 KPI87883.1 - 0.21 11.7 3.9 0.51 10.4 3.9 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DuoxA PF10204.9 KPI87885.1 - 0.021 13.9 1.8 0.025 13.6 1.8 1.1 1 0 0 1 1 1 0 Dual oxidase maturation factor DUF3017 PF11222.8 KPI87885.1 - 0.026 14.7 1.3 0.043 14.1 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3017) Wzy_C PF04932.15 KPI87885.1 - 0.042 13.5 0.1 0.042 13.5 0.1 1.1 1 0 0 1 1 1 0 O-Antigen ligase DUF4131 PF13567.6 KPI87885.1 - 0.054 13.2 1.0 0.054 13.1 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) WBP-1 PF11669.8 KPI87885.1 - 3.7 8.3 9.4 5.2 7.8 9.4 1.5 1 1 0 1 1 1 0 WW domain-binding protein 1 LRR_6 PF13516.6 KPI87886.1 - 3.4e-13 48.5 8.5 0.014 15.4 0.0 6.8 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.7 KPI87886.1 - 6.3e-10 39.2 1.0 0.08 13.4 0.0 4.6 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87886.1 - 0.00034 20.3 5.9 1 9.2 0.1 4.9 3 2 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 KPI87886.1 - 0.0022 18.3 1.3 64 4.7 0.0 5.4 5 1 0 5 5 5 0 Leucine Rich Repeat Pex14_N PF04695.13 KPI87887.1 - 0.12 13.0 3.4 0.46 11.1 3.4 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LacAB_rpiB PF02502.18 KPI87888.1 - 8.8e-48 161.8 0.8 9.9e-48 161.7 0.8 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase GTP_EFTU PF00009.27 KPI87889.1 - 4.5e-56 189.5 0.0 8.6e-56 188.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 KPI87889.1 - 2.1e-20 72.6 0.0 4e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KPI87889.1 - 1.3e-14 54.0 0.1 3.5e-14 52.6 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 KPI87889.1 - 7.3e-06 25.8 0.1 1.4e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 KPI87889.1 - 2.7e-05 24.5 0.0 7.4e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KPI87889.1 - 6.5e-05 23.0 0.1 0.00017 21.6 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KPI87889.1 - 0.00022 20.6 0.0 0.00046 19.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family FeoB_N PF02421.18 KPI87889.1 - 0.044 13.3 0.9 0.46 10.0 0.1 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Peptidase_S15 PF02129.18 KPI87890.1 - 2.9e-59 200.9 0.1 9.1e-59 199.2 0.1 1.7 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 KPI87890.1 - 2.9e-32 112.4 0.0 4.3e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 KPI87890.1 - 8.2e-07 28.5 0.1 4.3e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KPI87890.1 - 8.6e-06 25.4 0.3 0.00014 21.4 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KPI87890.1 - 0.00019 21.2 0.0 0.00029 20.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 KPI87890.1 - 0.0012 17.6 0.0 0.0021 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) DUF2228 PF10228.9 KPI87891.1 - 1e-22 81.1 0.0 2.1e-13 50.6 0.0 4.1 3 1 0 3 3 3 2 Uncharacterised conserved protein (DUF2228) zf-CCHH PF10283.9 KPI87891.1 - 6e-10 38.9 2.7 1.7e-09 37.5 2.7 1.8 1 0 0 1 1 1 1 PBZ domain DUF3168 PF11367.8 KPI87891.1 - 0.02 15.1 0.3 0.47 10.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3168) CorA PF01544.18 KPI87892.1 - 9.3e-07 28.4 1.0 9.3e-07 28.4 1.0 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Renin_r PF07850.14 KPI87893.1 - 0.31 11.7 2.3 0.47 11.1 2.3 1.3 1 0 0 1 1 1 0 Renin receptor-like protein Na_H_Exchanger PF00999.21 KPI87894.1 - 6.3e-49 166.8 43.8 9.3e-49 166.2 43.8 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SET PF00856.28 KPI87895.1 - 1.5e-10 41.7 0.0 3.3e-10 40.6 0.0 1.8 1 1 0 1 1 1 1 SET domain FAD-oxidase_C PF02913.19 KPI87896.1 - 1.3e-47 162.5 0.0 2e-47 161.9 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KPI87896.1 - 2e-30 105.3 0.3 4.9e-30 104.1 0.3 1.7 1 0 0 1 1 1 1 FAD binding domain SET PF00856.28 KPI87898.1 - 3.1e-13 50.5 0.3 2.5e-10 41.0 0.0 3.1 2 1 0 2 2 2 2 SET domain zf-MYND PF01753.18 KPI87898.1 - 0.005 16.9 5.1 0.005 16.9 5.1 3.4 4 0 0 4 4 4 1 MYND finger zf-Mss51 PF13824.6 KPI87898.1 - 0.0069 16.5 3.3 0.019 15.0 3.3 1.7 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 DUF676 PF05057.14 KPI87899.1 - 1.1e-10 41.4 0.0 2e-09 37.3 0.0 2.1 2 0 0 2 2 2 2 Putative serine esterase (DUF676) DUF1738 PF08401.11 KPI87901.1 - 0.0006 19.9 1.0 0.44 10.7 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF1738) DUF1738 PF08401.11 KPI87902.1 - 6.7e-05 23.0 0.0 0.0068 16.5 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1738) Mitoc_mL59 PF18126.1 KPI87902.1 - 0.031 14.6 0.0 0.063 13.6 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein mL59 MMR_HSR1 PF01926.23 KPI87903.1 - 6.9e-11 42.2 0.0 2.5e-10 40.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KPI87903.1 - 1.3e-05 25.3 0.1 0.00016 21.8 0.1 2.3 1 1 1 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 KPI87903.1 - 0.004 17.1 0.0 0.071 13.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 KPI87903.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 KPI87903.1 - 0.13 12.0 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ins145_P3_rec PF08709.11 KPI87904.1 - 8.5e-27 93.7 0.0 1.5e-25 89.6 0.0 2.4 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RIH_assoc PF08454.11 KPI87904.1 - 3.7e-24 84.5 0.3 1.1e-23 82.9 0.3 1.9 1 0 0 1 1 1 1 RyR and IP3R Homology associated Ion_trans PF00520.31 KPI87904.1 - 4.9e-11 42.3 14.2 1.3e-10 41.0 14.2 1.7 1 1 0 1 1 1 1 Ion transport protein RYDR_ITPR PF01365.21 KPI87904.1 - 6.1e-06 25.8 0.2 0.00024 20.6 0.0 3.5 3 0 0 3 3 3 1 RIH domain MIR PF02815.19 KPI87904.1 - 0.0063 16.4 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 MIR domain LRR_4 PF12799.7 KPI87905.1 - 5.4e-07 29.8 4.1 0.36 11.3 0.0 5.8 5 1 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI87905.1 - 0.00021 21.0 6.3 0.043 13.6 0.0 5.5 7 0 0 7 7 7 2 Leucine rich repeat RRM_1 PF00076.22 KPI87906.1 - 1.9e-12 46.8 0.0 3e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KPI87907.1 - 1.6e-12 47.1 0.0 2.6e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KPI87908.1 - 1.4e-11 44.0 0.0 2.5e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3437 PF11919.8 KPI87910.1 - 8.7e-18 64.0 0.2 9.4e-17 60.7 0.0 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) Radial_spoke PF04712.12 KPI87911.1 - 4.4e-05 22.6 8.0 0.0064 15.5 6.8 2.8 2 1 0 2 2 2 1 Radial spokehead-like protein CENP-B_dimeris PF09026.10 KPI87911.1 - 0.0056 17.1 5.1 0.0096 16.3 5.1 1.3 1 0 0 1 1 1 1 Centromere protein B dimerisation domain BNR PF02012.20 KPI87911.1 - 0.14 12.2 0.8 0.44 10.8 0.8 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat NOA36 PF06524.12 KPI87911.1 - 9.7 5.4 8.4 14 4.9 8.4 1.2 1 0 0 1 1 1 0 NOA36 protein IML1 PF12257.8 KPI87912.1 - 8.2e-35 120.3 0.0 2.1e-27 96.0 0.0 3.0 2 1 0 2 2 2 2 Vacuolar membrane-associated protein Iml1 Ion_trans PF00520.31 KPI87914.1 - 2.2 7.5 10.4 3.4 6.8 10.4 1.2 1 0 0 1 1 1 0 Ion transport protein Pkinase PF00069.25 KPI87915.1 - 4.4e-77 259.0 0.0 5.1e-77 258.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87915.1 - 1.3e-39 136.0 0.0 1.6e-39 135.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI87915.1 - 4.4e-11 42.6 0.0 8.4e-09 35.1 0.0 2.1 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 KPI87915.1 - 0.0003 20.2 0.3 0.0005 19.5 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI87915.1 - 0.00031 19.8 0.2 0.00043 19.3 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI87915.1 - 0.0048 16.8 0.2 0.19 11.6 0.1 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 KPI87917.1 - 2.7e-48 164.6 0.0 4.6e-48 163.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87917.1 - 5.9e-34 117.5 0.1 1.1e-32 113.3 0.1 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase PX PF00787.24 KPI87917.1 - 0.0058 16.6 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.6 KPI87917.1 - 0.18 11.1 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF1776 PF08643.10 KPI87918.1 - 0.089 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) UQ_con PF00179.26 KPI87919.1 - 4.3e-38 130.1 0.0 9.3e-38 129.0 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KPI87919.1 - 0.052 13.2 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Mid2 PF04478.12 KPI87920.1 - 0.051 13.4 0.1 0.16 11.8 0.1 1.9 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor PGM_PMM_I PF02878.16 KPI87921.1 - 4.1e-15 55.7 0.0 2.2e-07 30.6 0.0 2.6 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 KPI87921.1 - 3.1e-10 40.1 0.1 6.8e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 KPI87921.1 - 0.0015 19.1 0.2 0.014 16.0 0.1 2.7 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 KPI87921.1 - 0.031 14.5 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DnaJ PF00226.31 KPI87923.1 - 1.2e-07 31.8 0.1 2.4e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 KPI87923.1 - 0.001 19.1 1.8 0.0032 17.5 0.0 2.3 2 0 0 2 2 2 1 Pam16 DnaJ PF00226.31 KPI87924.1 - 1e-05 25.5 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain SH3BGR PF04908.15 KPI87925.1 - 0.016 15.4 0.0 0.045 13.9 0.0 1.7 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein AKNA PF12443.8 KPI87925.1 - 2.1 9.0 5.0 0.92 10.2 0.3 2.7 2 0 0 2 2 2 0 AT-hook-containing transcription factor VPS13_C PF16909.5 KPI87926.1 - 3.5e-20 72.5 0.2 1.1e-13 51.3 0.0 2.5 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13_mid_rpt PF16910.5 KPI87926.1 - 1.2e-09 38.0 0.0 5.7e-07 29.2 0.0 3.0 3 0 0 3 3 3 2 Repeating coiled region of VPS13 SHR-BD PF06650.12 KPI87926.1 - 2.3e-06 27.2 0.0 0.18 11.1 0.0 4.2 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 Glyco_hydro_18 PF00704.28 KPI87927.1 - 7.8e-44 150.7 0.0 1e-43 150.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_C3G PF12381.8 KPI87927.1 - 0.16 11.4 0.1 0.39 10.1 0.0 1.6 2 0 0 2 2 2 0 Tungro spherical virus-type peptidase Mem_trans PF03547.18 KPI87928.1 - 1.9e-09 36.4 20.6 8.9e-08 30.9 0.2 3.9 4 0 0 4 4 4 3 Membrane transport protein Spermine_synth PF01564.17 KPI87929.1 - 0.0078 15.6 0.0 0.017 14.5 0.0 1.4 1 1 0 1 1 1 1 Spermine/spermidine synthase domain BILBO1_N PF18281.1 KPI87930.1 - 0.00011 22.6 0.0 0.00035 20.9 0.0 1.8 1 1 0 1 1 1 1 BILBO1 N-terminal domain EF-hand_1 PF00036.32 KPI87930.1 - 0.0013 18.1 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 EF hand Fe-S_biosyn PF01521.20 KPI87931.1 - 3.2e-07 30.5 0.0 1.8e-05 24.9 0.0 2.4 3 0 0 3 3 3 2 Iron-sulphur cluster biosynthesis JAB PF01398.21 KPI87933.1 - 1e-20 73.9 0.0 1.5e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KPI87933.1 - 0.0009 19.0 0.0 0.0019 17.9 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain RAP1 PF07218.11 KPI87934.1 - 6.9 4.8 5.1 8.2 4.6 5.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pkinase PF00069.25 KPI87935.1 - 2.7e-34 118.8 0.0 4.6e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87935.1 - 9.3e-26 90.7 0.0 1.9e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI87935.1 - 2e-07 30.2 0.0 3.3e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Nop52 PF05997.12 KPI87936.1 - 6.7e-31 107.8 3.8 1.2e-25 90.6 0.7 3.7 4 0 0 4 4 4 3 Nucleolar protein,Nop52 IKKbetaNEMObind PF12179.8 KPI87936.1 - 0.017 15.1 0.0 0.045 13.8 0.0 1.7 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain ING PF12998.7 KPI87936.1 - 0.12 12.9 0.8 0.45 11.1 0.8 1.9 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding EF-hand_6 PF13405.6 KPI87939.1 - 2e-16 58.4 6.0 0.00021 21.0 0.0 4.2 4 1 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KPI87939.1 - 4.9e-16 57.0 12.5 6.4e-06 25.4 0.2 4.7 4 1 1 5 5 5 3 EF hand EF-hand_7 PF13499.6 KPI87939.1 - 6.3e-16 58.6 0.2 7.4e-09 35.9 0.2 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KPI87939.1 - 8.1e-13 48.0 2.9 3.1e-06 26.9 0.1 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KPI87939.1 - 1e-12 46.9 11.0 1.4e-05 24.3 0.0 4.6 4 1 0 4 4 4 2 EF hand EF-hand_10 PF14788.6 KPI87939.1 - 0.0083 16.0 0.1 0.83 9.6 0.0 3.1 3 0 0 3 3 3 1 EF hand p25-alpha PF05517.12 KPI87939.1 - 0.033 14.3 0.7 20 5.3 0.0 3.2 2 1 1 3 3 3 0 p25-alpha Snf7 PF03357.21 KPI87940.1 - 5e-27 94.6 13.3 5e-27 94.6 13.3 1.3 1 1 0 1 1 1 1 Snf7 Phage_P2_GpU PF06995.11 KPI87940.1 - 0.072 12.7 0.2 2.3 7.9 0.0 2.1 1 1 1 2 2 2 0 Phage P2 GpU Dynein_light PF01221.18 KPI87941.1 - 6.1e-25 87.4 0.6 7.2e-25 87.1 0.6 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 Glycos_transf_1 PF00534.20 KPI87942.1 - 3.5e-25 88.5 0.0 6.2e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KPI87942.1 - 1.1e-17 64.7 0.0 2.2e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KPI87942.1 - 1.3e-05 25.3 0.0 2.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 KPI87942.1 - 0.0066 16.8 0.0 0.022 15.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF2618 PF10940.8 KPI87942.1 - 0.039 13.8 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) Methyltransf_23 PF13489.6 KPI87943.1 - 2.8e-17 63.0 0.0 4.4e-16 59.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI87943.1 - 7.5e-14 52.2 0.0 1.3e-12 48.2 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KPI87943.1 - 4.4e-11 42.6 0.0 2.6e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 KPI87943.1 - 1.6e-10 41.5 0.0 2.6e-07 31.2 0.0 3.4 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 KPI87943.1 - 2.2e-07 30.8 0.0 6.7e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KPI87943.1 - 4e-07 30.7 0.0 0.0006 20.5 0.0 3.8 4 1 0 4 4 4 1 Methyltransferase domain Sigma70_r1_2 PF00140.20 KPI87943.1 - 0.007 16.4 0.4 0.016 15.2 0.4 1.7 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 FSH1 PF03959.13 KPI87943.1 - 0.1 12.2 0.1 0.42 10.2 0.0 2.0 2 1 1 3 3 3 0 Serine hydrolase (FSH1) TPR_17 PF13431.6 KPI87945.1 - 0.044 14.2 0.4 73 4.1 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat PGAP1 PF07819.13 KPI87945.1 - 0.088 12.5 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein TPR_11 PF13414.6 KPI87945.1 - 0.13 12.0 0.2 31 4.3 0.0 3.6 4 0 0 4 4 4 0 TPR repeat FAM184 PF15665.5 KPI87946.1 - 0.0026 17.6 41.7 0.0026 17.6 41.7 5.7 1 1 4 5 5 5 2 Family with sequence similarity 184, A and B HALZ PF02183.18 KPI87946.1 - 0.0041 17.3 3.5 0.0041 17.3 3.5 7.5 8 0 0 8 8 8 2 Homeobox associated leucine zipper Pkinase PF00069.25 KPI87947.1 - 8.5e-62 208.9 0.0 1.5e-33 116.3 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI87947.1 - 8.6e-29 100.6 0.0 3.9e-19 68.9 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Spt20 PF12090.8 KPI87947.1 - 1.5 8.4 7.0 2.2 7.8 7.0 1.2 1 0 0 1 1 1 0 Spt20 family FIBP PF05427.11 KPI87950.1 - 8.5e-05 22.0 0.1 0.61 9.3 0.0 3.4 4 0 0 4 4 4 2 Acidic fibroblast growth factor binding (FIBP) WD40 PF00400.32 KPI87951.1 - 1.3e-06 29.0 5.0 0.31 12.0 0.1 7.1 8 0 0 8 8 8 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI87951.1 - 4.2e-05 23.8 0.0 6.9 7.1 0.0 4.7 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KPI87951.1 - 0.081 12.5 1.2 0.43 10.1 0.5 2.5 2 0 0 2 2 2 0 PQQ-like domain PQQ_3 PF13570.6 KPI87951.1 - 0.63 10.6 3.6 6.9 7.3 0.2 4.5 6 0 0 6 6 6 0 PQQ-like domain NAPRTase PF04095.16 KPI87952.1 - 5e-73 245.7 0.0 6.8e-73 245.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 KPI87952.1 - 7.4e-38 129.8 0.0 1.3e-37 128.9 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Arm-DNA-bind_1 PF09003.10 KPI87953.1 - 0.019 15.1 0.3 0.048 13.8 0.3 1.6 1 0 0 1 1 1 0 Bacteriophage lambda integrase, Arm DNA-binding domain WW PF00397.26 KPI87953.1 - 0.85 9.8 12.2 6.9 6.9 12.2 2.4 1 1 0 1 1 1 0 WW domain Skp1 PF01466.19 KPI87954.1 - 6.5e-08 32.6 0.2 1e-07 31.9 0.2 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Rhodanese PF00581.20 KPI87955.1 - 1.3e-06 28.9 0.0 1.7e-06 28.5 0.0 1.3 1 1 0 1 1 1 1 Rhodanese-like domain DAGAT PF03982.13 KPI87957.1 - 2.2e-20 72.8 0.8 1.8e-12 46.8 0.0 4.8 5 0 0 5 5 5 3 Diacylglycerol acyltransferase DUF3016 PF11454.8 KPI87957.1 - 0.055 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3016) Cation_ATPase_C PF00689.21 KPI87958.1 - 9.4e-40 136.3 6.7 2.6e-39 134.8 6.7 1.8 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KPI87958.1 - 1.5e-29 102.8 2.3 1.5e-29 102.8 2.3 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KPI87958.1 - 1.7e-12 48.1 0.0 7.9e-07 29.6 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KPI87958.1 - 6e-08 32.3 0.0 1.7e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KPI87958.1 - 3.7e-07 30.2 0.0 7.4e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KPI87958.1 - 0.00014 21.7 0.4 0.00023 21.0 0.4 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PSP1 PF04468.12 KPI87959.1 - 2e-12 47.2 0.8 1.2e-11 44.7 0.3 2.5 2 1 0 2 2 2 1 PSP1 C-terminal conserved region PPTA PF01239.22 KPI87960.1 - 4.1e-30 102.6 11.7 4.3e-09 35.8 0.3 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat OCRE PF17780.1 KPI87961.1 - 0.00017 21.5 7.9 0.00032 20.7 7.9 1.4 1 0 0 1 1 1 1 OCRE domain DUF4407 PF14362.6 KPI87962.1 - 0.37 10.1 3.9 0.11 11.8 0.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Voltage_CLC PF00654.20 KPI87964.1 - 1.4e-88 297.5 25.7 2e-88 297.0 24.0 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KPI87964.1 - 4.9e-10 39.7 0.1 3.4e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 CBS domain YEATS PF03366.16 KPI87966.1 - 1.8e-07 31.0 0.0 3.5e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 YEATS family DUF4587 PF15248.6 KPI87966.1 - 0.4 11.5 3.1 1.9 9.4 3.1 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4587) Guanylate_kin PF00625.21 KPI87967.1 - 2.1e-49 167.7 0.0 2.6e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 KPI87967.1 - 2.1e-06 28.3 0.2 6.1e-06 26.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 KPI87967.1 - 2.6e-05 24.3 0.0 3.4e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KPI87967.1 - 0.00023 21.6 0.2 0.0025 18.2 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KPI87967.1 - 0.00084 19.5 0.0 0.0058 16.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI87967.1 - 0.0019 18.5 0.0 0.0061 16.8 0.0 1.9 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KPI87967.1 - 0.0042 17.0 0.0 0.0073 16.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_17 PF13207.6 KPI87967.1 - 0.0046 17.4 0.1 0.59 10.6 0.0 2.8 2 1 1 3 3 3 1 AAA domain ADK PF00406.22 KPI87967.1 - 0.0088 16.1 0.1 0.53 10.4 0.0 2.3 2 0 0 2 2 2 1 Adenylate kinase Rad17 PF03215.15 KPI87967.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.5 1 1 0 1 1 1 0 Rad17 P-loop domain dNK PF01712.19 KPI87967.1 - 0.042 13.7 0.0 2.4 8.0 0.1 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase GIT_SHD PF08518.11 KPI87967.1 - 0.17 11.5 1.6 0.61 9.8 0.3 2.4 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT ABC_tran PF00005.27 KPI87967.1 - 0.21 12.1 0.2 0.47 11.0 0.2 1.9 1 1 0 1 1 1 0 ABC transporter zf-CW PF07496.15 KPI87968.1 - 3.2e-10 39.9 18.7 6e-08 32.6 6.7 4.3 4 0 0 4 4 4 3 CW-type Zinc Finger Yippee-Mis18 PF03226.14 KPI87969.1 - 0.0002 21.6 2.6 0.43 10.8 0.2 2.6 2 0 0 2 2 2 2 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 KPI87969.1 - 0.27 11.5 3.7 2.2 8.5 0.2 2.6 2 0 0 2 2 2 0 C-terminal domain of RIG-I Nup88 PF10168.9 KPI87969.1 - 0.4 8.4 16.1 0.57 7.9 16.1 1.1 1 0 0 1 1 1 0 Nuclear pore component LIM PF00412.22 KPI87969.1 - 1.6 9.0 6.0 0.29 11.4 0.9 2.1 2 0 0 2 2 2 0 LIM domain SWIRM-assoc_1 PF16495.5 KPI87969.1 - 1.7 8.7 14.8 0.81 9.7 11.8 2.1 2 0 0 2 2 2 0 SWIRM-associated region 1 SlyX PF04102.12 KPI87969.1 - 2.6 8.7 19.0 2.6 8.7 5.3 3.0 1 1 1 2 2 2 0 SlyX DUF16 PF01519.16 KPI87969.1 - 5.5 7.5 16.3 41 4.7 16.3 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 DNA_photolyase PF00875.18 KPI87970.1 - 0.044 13.8 0.2 0.091 12.8 0.2 1.5 1 0 0 1 1 1 0 DNA photolyase TolA_bind_tri PF16331.5 KPI87970.1 - 0.61 10.2 12.3 0.94 9.6 10.3 2.4 1 1 0 1 1 1 0 TolA binding protein trimerisation TIG PF01833.24 KPI87972.1 - 0.0014 18.7 15.0 3.2 7.9 0.0 4.7 4 0 0 4 4 4 3 IPT/TIG domain Myco_19_kDa PF05481.12 KPI87972.1 - 0.052 13.8 2.4 0.068 13.5 0.7 2.2 2 0 0 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen DUF4625 PF15418.6 KPI87972.1 - 0.1 12.8 0.0 64 3.8 0.0 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4625) PI3_PI4_kinase PF00454.27 KPI87973.1 - 5.3e-56 190.2 0.0 1.6e-55 188.6 0.0 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 KPI87973.1 - 1.6e-22 80.2 0.1 3.8e-22 79.0 0.1 1.7 1 0 0 1 1 1 1 FAT domain DUF3385 PF11865.8 KPI87973.1 - 8.6e-16 58.3 3.6 1.8e-13 50.7 0.5 4.0 3 1 0 3 3 3 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 KPI87973.1 - 3.1e-14 53.2 2.6 1.2e-13 51.3 0.5 3.3 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain FATC PF02260.20 KPI87973.1 - 6.7e-11 41.8 0.1 1.6e-10 40.6 0.1 1.7 1 0 0 1 1 1 1 FATC domain PDZ PF00595.24 KPI87973.1 - 0.00061 20.1 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KPI87973.1 - 0.0014 18.4 1.4 0.0023 17.7 0.2 2.1 2 0 0 2 2 2 1 PDZ domain RIX1 PF08167.12 KPI87973.1 - 0.0089 15.8 0.3 0.75 9.5 0.0 4.0 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis IFRD PF05004.13 KPI87973.1 - 0.015 14.4 2.1 0.36 9.9 0.2 3.6 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) TPR_11 PF13414.6 KPI87973.1 - 0.021 14.5 0.0 0.053 13.2 0.0 1.6 1 0 0 1 1 1 0 TPR repeat DUF5304 PF17230.2 KPI87973.1 - 0.062 13.5 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5304) DUF5584 PF17822.1 KPI87973.1 - 0.096 12.1 0.0 0.84 9.1 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5584) HEAT_2 PF13646.6 KPI87973.1 - 0.098 13.1 13.9 0.36 11.3 0.1 5.6 5 1 1 6 6 6 0 HEAT repeats Glycos_trans_3N PF02885.17 KPI87973.1 - 0.1 12.5 0.0 0.35 10.7 0.0 2.0 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain SporV_AA PF12164.8 KPI87973.1 - 0.58 10.5 1.7 3.9 7.9 0.0 3.0 3 0 0 3 3 3 0 Stage V sporulation protein AA Arm PF00514.23 KPI87973.1 - 1.3 9.2 5.1 33 4.7 0.0 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KPI87973.1 - 4.5 7.8 12.7 16 6.1 0.0 6.6 7 0 0 7 7 6 0 HEAT repeat NIF PF03031.18 KPI87975.1 - 1.5e-24 86.5 0.0 2.6e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.12 KPI87975.1 - 0.00013 21.6 0.0 0.00018 21.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF705) UMPH-1 PF05822.12 KPI87975.1 - 0.032 13.7 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) Tox-WTIP PF15654.6 KPI87975.1 - 0.048 14.1 0.0 0.16 12.4 0.0 1.9 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif Pet191_N PF10203.9 KPI87976.1 - 1.2e-08 35.1 0.9 1.8e-08 34.5 0.9 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 HATPase_c PF02518.26 KPI87977.1 - 7.6e-12 45.7 0.0 1.6e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KPI87977.1 - 0.0058 16.5 0.0 0.017 15.0 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_6 PF12774.7 KPI87979.1 - 5.6e-154 512.0 0.0 7.4e-153 508.3 0.0 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 KPI87979.1 - 1.2e-136 456.6 3.8 1.2e-136 456.6 3.8 3.3 2 0 0 2 2 1 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 KPI87979.1 - 2.3e-113 379.3 9.7 2.3e-113 379.3 9.7 5.0 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI87979.1 - 8.4e-102 339.9 0.1 3.1e-101 338.1 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KPI87979.1 - 7e-79 265.2 1.5 2.9e-78 263.2 0.3 2.6 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KPI87979.1 - 1.6e-73 246.5 0.0 1.6e-73 246.5 0.0 3.1 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI87979.1 - 1.1e-64 217.3 7.1 2.7e-46 157.4 0.0 4.9 5 0 0 5 5 5 3 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI87979.1 - 1.7e-50 171.0 0.1 6.1e-50 169.2 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI87979.1 - 2e-42 144.1 0.0 4.4e-41 139.7 0.0 3.0 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI87979.1 - 4.2e-40 137.8 8.4 8e-40 136.9 8.4 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KPI87979.1 - 6.8e-22 78.0 0.8 1.6e-07 31.4 0.0 7.4 6 1 0 6 6 6 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KPI87979.1 - 1.4e-21 76.9 0.0 8.1e-21 74.5 0.0 2.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KPI87979.1 - 1.7e-16 60.2 0.0 5.9e-16 58.5 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KPI87979.1 - 3.2e-10 40.6 0.4 0.036 14.4 0.0 6.4 5 0 0 5 5 5 1 AAA ATPase domain AAA_22 PF13401.6 KPI87979.1 - 1.2e-07 32.0 0.5 0.21 11.9 0.0 5.8 5 0 0 5 5 5 2 AAA domain AAA PF00004.29 KPI87979.1 - 2.3e-07 31.3 3.4 0.66 10.4 0.0 6.5 6 0 0 6 6 5 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KPI87979.1 - 7e-05 23.0 3.9 0.43 10.7 0.0 5.7 5 0 0 5 5 5 1 AAA domain AAA_29 PF13555.6 KPI87979.1 - 0.0026 17.5 0.2 0.082 12.7 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 KPI87979.1 - 0.0067 16.2 3.6 2.2 8.0 0.1 3.9 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 KPI87979.1 - 0.0094 16.5 3.8 4.2 7.9 0.0 4.8 5 0 0 5 5 3 1 AAA domain RNA_helicase PF00910.22 KPI87979.1 - 0.017 15.5 0.6 3.4 8.1 0.0 3.4 3 0 0 3 3 3 0 RNA helicase RsgA_GTPase PF03193.16 KPI87979.1 - 0.017 15.0 0.1 0.017 15.0 0.1 3.4 4 0 0 4 4 3 0 RsgA GTPase ABC_tran PF00005.27 KPI87979.1 - 0.019 15.4 3.8 1.2 9.6 0.0 4.6 5 0 0 5 5 3 0 ABC transporter Rad17 PF03215.15 KPI87979.1 - 0.023 14.6 0.3 2.6 7.9 0.0 3.0 2 0 0 2 2 2 0 Rad17 P-loop domain T2SSE PF00437.20 KPI87979.1 - 0.032 13.3 0.2 1.6 7.7 0.1 3.1 3 0 0 3 3 3 0 Type II/IV secretion system protein SMC_N PF02463.19 KPI87979.1 - 0.061 12.7 0.1 4 6.8 0.0 2.9 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain COG5 PF10392.9 KPI87979.1 - 0.62 10.3 7.4 9.9 6.3 1.8 4.0 3 0 0 3 3 2 0 Golgi transport complex subunit 5 DnaJ PF00226.31 KPI87980.1 - 2.7e-18 65.8 1.7 4.1e-18 65.3 0.1 2.0 2 0 0 2 2 2 1 DnaJ domain VanY PF02557.17 KPI87980.1 - 0.088 12.6 0.4 0.21 11.4 0.4 1.6 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase LSM PF01423.22 KPI87981.1 - 4e-12 45.7 0.1 5.2e-12 45.3 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KPI87981.1 - 9.2e-05 22.5 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain MIP PF00230.20 KPI87982.1 - 6.2e-33 114.4 21.7 2.6e-32 112.4 21.7 1.7 1 1 0 1 1 1 1 Major intrinsic protein F-box-like PF12937.7 KPI87983.1 - 0.00081 19.2 0.2 0.0027 17.5 0.0 1.9 2 0 0 2 2 2 1 F-box-like TPR_1 PF00515.28 KPI87984.1 - 1e-08 34.7 9.2 0.019 14.8 0.0 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI87984.1 - 3.5e-07 29.8 0.2 0.037 13.7 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 KPI87984.1 - 6.2e-07 29.1 5.1 0.56 10.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 KPI87984.1 - 0.00026 21.4 1.9 1.7 9.4 0.6 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI87984.1 - 0.00047 20.6 0.1 0.039 14.5 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI87984.1 - 0.0016 19.1 0.2 3 8.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI87984.1 - 0.0097 16.0 4.6 0.21 11.9 0.1 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI87984.1 - 0.019 15.2 3.7 0.18 12.1 2.8 2.7 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KPI87984.1 - 0.023 15.0 1.3 14 6.1 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI87984.1 - 0.079 13.0 0.5 21 5.4 0.9 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI87984.1 - 0.11 12.6 0.7 8.2 6.7 0.2 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Ribosomal_L14 PF00238.19 KPI87985.1 - 5.2e-21 75.0 0.1 7e-21 74.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e ANAPC4_WD40 PF12894.7 KPI87988.1 - 0.021 15.1 0.1 40 4.6 0.0 4.4 4 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain PGM_PMM_I PF02878.16 KPI87989.1 - 2.2e-38 131.1 0.0 4.5e-38 130.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 KPI87989.1 - 7.4e-18 65.1 0.0 1.9e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 KPI87989.1 - 2.9e-13 50.0 0.1 6.2e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 KPI87989.1 - 2.8e-05 24.2 0.1 0.00017 21.7 0.0 2.4 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain FTCD_C PF04961.12 KPI87990.1 - 0.078 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Actin PF00022.19 KPI87991.1 - 4.4e-37 127.7 0.0 3.6e-36 124.7 0.0 2.3 1 1 0 1 1 1 1 Actin FtsA PF14450.6 KPI87991.1 - 0.0087 16.5 0.0 0.018 15.4 0.0 1.7 1 1 0 1 1 1 1 Cell division protein FtsA TetR_C_6 PF13977.6 KPI87991.1 - 0.061 13.5 0.8 1.3 9.3 0.1 2.8 3 0 0 3 3 3 0 BetI-type transcriptional repressor, C-terminal Pox_L5 PF04872.13 KPI87991.1 - 0.21 11.5 0.1 1.1 9.1 0.0 2.2 3 0 0 3 3 3 0 Poxvirus L5 protein family Aminotran_1_2 PF00155.21 KPI87994.1 - 1.1e-44 153.2 0.0 1.5e-44 152.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF501 PF04417.12 KPI87996.1 - 3.3e-27 95.0 1.4 5.2e-27 94.4 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF501) DUF778 PF05608.12 KPI87997.1 - 0.32 11.3 3.0 0.72 10.2 2.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF778) Tfb4 PF03850.14 KPI87997.1 - 3.4 7.1 5.8 5.1 6.5 4.9 1.7 1 1 0 1 1 1 0 Transcription factor Tfb4 Ins_P5_2-kin PF06090.12 KPI87998.1 - 9.9e-25 87.7 0.0 1.7e-24 86.9 0.0 1.4 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Ribosomal_L13 PF00572.18 KPI88000.1 - 2.7e-27 95.5 0.0 3.7e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 ATP-synt_ab PF00006.25 KPI88001.1 - 2.2e-105 351.0 0.0 3.5e-105 350.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 KPI88001.1 - 1.3e-45 154.1 0.6 2.7e-45 153.2 0.1 1.8 2 0 0 2 2 2 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 KPI88001.1 - 3.1e-14 53.2 1.8 3.1e-14 53.2 1.8 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DUF2737 PF10930.8 KPI88001.1 - 0.075 12.6 0.1 5.9 6.5 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2737) EMP70 PF02990.16 KPI88002.1 - 8.1e-133 443.8 7.8 1e-132 443.5 7.8 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF2976 PF11190.8 KPI88002.1 - 2.8 7.8 17.2 0.14 11.9 0.7 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2976) Peptidase_C2 PF00648.21 KPI88003.1 - 1.8e-18 66.6 0.0 2.9e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Kre28 PF17097.5 KPI88003.1 - 4.5e-06 25.9 12.9 1.6 7.6 0.0 8.8 9 0 0 9 9 9 3 Spindle pole body component YfdX PF10938.8 KPI88003.1 - 0.11 12.5 0.0 0.11 12.5 0.0 5.9 4 1 1 5 5 5 0 YfdX protein Radial_spoke_3 PF06098.11 KPI88004.1 - 5e-108 360.7 30.2 5.8e-108 360.5 30.2 1.0 1 0 0 1 1 1 1 Radial spoke protein 3 Amastin PF07344.11 KPI88006.1 - 4.9e-08 33.0 7.1 4.9e-08 33.0 7.1 2.0 2 0 0 2 2 2 2 Amastin surface glycoprotein Rep_fac_C PF08542.11 KPI88007.1 - 1.5e-18 67.0 0.0 2e-17 63.4 0.0 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KPI88007.1 - 3.3e-12 46.5 0.1 3.6e-11 43.1 0.1 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 KPI88007.1 - 1.6e-11 44.7 0.7 6.7e-11 42.7 0.2 2.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI88007.1 - 1.1e-07 32.2 0.0 3.1e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KPI88007.1 - 1.6e-07 31.5 0.0 3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_19 PF13245.6 KPI88007.1 - 3.4e-05 24.2 1.1 0.0017 18.7 0.2 2.5 2 1 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.13 KPI88007.1 - 4.1e-05 23.4 0.1 0.00013 21.8 0.1 1.8 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 KPI88007.1 - 5.6e-05 22.6 0.0 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KPI88007.1 - 0.00011 22.7 1.2 0.0011 19.4 1.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KPI88007.1 - 0.00016 21.4 0.0 0.00073 19.3 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 KPI88007.1 - 0.00039 20.7 0.0 0.0011 19.3 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 KPI88007.1 - 0.0015 18.3 0.1 0.0034 17.2 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KPI88007.1 - 0.0019 18.0 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI88007.1 - 0.0023 17.7 0.5 0.0065 16.2 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI88007.1 - 0.0052 16.8 0.2 0.074 13.1 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KPI88007.1 - 0.012 15.2 1.0 0.036 13.6 0.1 2.3 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 KPI88007.1 - 0.02 15.3 0.0 0.068 13.6 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_14 PF13173.6 KPI88007.1 - 0.022 14.8 0.0 0.21 11.6 0.0 2.2 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KPI88007.1 - 0.024 13.9 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 KPI88007.1 - 0.051 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein SRP54 PF00448.22 KPI88007.1 - 0.055 13.1 0.0 0.14 11.8 0.0 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 KPI88007.1 - 0.071 13.3 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KPI88007.1 - 0.094 13.3 0.1 0.26 11.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_3 PF07726.11 KPI88007.1 - 0.098 12.5 0.1 19 5.1 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.25 KPI88008.1 - 9.1e-64 215.4 0.0 1e-63 215.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88008.1 - 1.6e-27 96.4 0.0 2.2e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI88008.1 - 0.0027 16.6 0.0 0.0052 15.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KPI88008.1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KPI88008.1 - 0.025 14.2 0.0 0.84 9.2 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-RING_2 PF13639.6 KPI88009.1 - 2.4e-08 34.2 25.0 3.6e-08 33.6 9.5 2.4 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.25 KPI88009.1 - 6.1e-07 29.2 9.9 6.1e-07 29.2 9.9 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI88009.1 - 2.3e-05 24.2 9.2 2.3e-05 24.2 9.2 2.8 2 1 1 3 3 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KPI88009.1 - 5.1e-05 23.0 8.0 5.1e-05 23.0 8.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI88009.1 - 0.00014 21.7 7.9 0.00014 21.7 7.9 3.1 2 2 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KPI88009.1 - 0.00014 21.7 6.9 0.00014 21.7 6.9 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI88009.1 - 0.00094 19.2 6.0 0.00094 19.2 6.0 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KPI88009.1 - 0.0017 18.6 10.4 0.0017 18.6 10.4 3.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-UDP PF14569.6 KPI88009.1 - 0.0026 17.9 2.3 0.0026 17.9 2.3 2.4 2 0 0 2 2 2 1 Zinc-binding RING-finger zf-RING_6 PF14835.6 KPI88009.1 - 0.46 10.4 4.2 1.4 8.8 4.2 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein FANCL_C PF11793.8 KPI88009.1 - 0.85 9.8 18.1 2.6 8.3 3.1 2.8 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.6 KPI88009.1 - 1.7 8.5 22.1 0.098 12.5 7.6 2.8 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain ANAPC4_WD40 PF12894.7 KPI88010.1 - 9e-05 22.7 0.5 0.96 9.8 0.0 4.1 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 KPI88010.1 - 0.00014 21.6 0.1 0.00032 20.5 0.1 1.6 1 0 0 1 1 1 1 LisH WD40 PF00400.32 KPI88010.1 - 0.00026 21.7 6.9 3 8.9 0.5 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat LisH_TPL PF17814.1 KPI88010.1 - 0.096 12.4 0.0 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 LisH-like dimerisation domain DUF4471 PF14740.6 KPI88011.1 - 3e-70 236.9 0.0 4.8e-70 236.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) DUF4470 PF14737.6 KPI88011.1 - 5.5e-14 52.1 0.2 3.6e-13 49.5 0.2 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4470) Lys PF00062.20 KPI88011.1 - 0.062 13.5 0.2 0.88 9.8 0.0 2.2 2 0 0 2 2 2 0 C-type lysozyme/alpha-lactalbumin family DUF3736 PF12540.8 KPI88011.1 - 0.17 12.0 1.3 0.23 11.6 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3736) ZU5 PF00791.20 KPI88012.1 - 0.078 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 ZU5 domain MRP-S28 PF10213.9 KPI88015.1 - 0.0012 19.3 0.0 0.0029 18.0 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein E2F_TDP PF02319.20 KPI88016.1 - 0.68 10.0 2.2 0.62 10.2 0.4 1.8 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain DUF4231 PF14015.6 KPI88018.1 - 0.086 13.3 0.2 0.17 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Cadherin_C_2 PF16492.5 KPI88018.1 - 0.42 11.4 1.4 4.3 8.1 0.0 2.3 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF5075 PF16825.5 KPI88019.1 - 1.5e-09 37.8 0.3 4.8e-09 36.2 0.3 1.8 1 1 0 1 1 1 1 IGP family C-type lectin domain Shisa PF13908.6 KPI88019.1 - 0.13 12.5 6.3 0.44 10.8 6.2 1.8 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator LRR_8 PF13855.6 KPI88020.1 - 0.05 13.4 4.8 0.42 10.4 0.1 3.4 3 0 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 KPI88020.1 - 0.083 13.3 3.5 0.099 13.1 0.6 2.5 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) GDYXXLXY PF14345.6 KPI88020.1 - 0.091 12.6 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 GDYXXLXY protein zf-C3HC4_3 PF13920.6 KPI88021.1 - 0.14 12.0 0.3 0.27 11.1 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4767 PF15983.5 KPI88021.1 - 0.19 12.0 0.0 0.32 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4767) UBA PF00627.31 KPI88023.1 - 1.9e-09 37.2 0.1 7.5e-09 35.3 0.1 2.1 1 0 0 1 1 1 1 UBA/TS-N domain XPC-binding PF09280.11 KPI88023.1 - 0.0059 16.3 7.3 0.12 12.1 1.7 3.0 2 1 0 2 2 2 2 XPC-binding domain HOIP-UBA PF16678.5 KPI88023.1 - 0.023 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 HOIP UBA domain pair DUF1697 PF08002.11 KPI88023.1 - 0.035 14.6 0.4 0.076 13.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) UBA_4 PF14555.6 KPI88023.1 - 0.046 13.5 0.0 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain Alpha_Helical PF18489.1 KPI88023.1 - 0.2 11.9 2.0 0.33 11.1 2.0 1.3 1 0 0 1 1 1 0 Alpha helical domain NAD_binding_1 PF00175.21 KPI88024.1 - 3.7e-18 66.2 0.0 6.4e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KPI88024.1 - 2.3e-15 56.7 0.0 3.7e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KPI88024.1 - 8.9e-05 22.7 0.0 0.0003 20.9 0.0 1.8 1 1 0 2 2 2 1 Ferric reductase NAD binding domain MdcE PF06833.11 KPI88024.1 - 0.26 10.7 0.0 0.43 10.0 0.0 1.3 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) Oxidored_q6 PF01058.22 KPI88025.1 - 1.2e-19 70.4 0.1 1.6e-19 70.0 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Dabb PF07876.12 KPI88026.1 - 1.6e-08 35.0 0.0 2.1e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Dabb PF07876.12 KPI88027.1 - 7e-07 29.8 0.0 1e-06 29.2 0.0 1.3 1 1 0 1 1 1 1 Stress responsive A/B Barrel Domain CmlA_N PF18456.1 KPI88027.1 - 0.037 13.3 0.1 0.055 12.8 0.0 1.3 1 1 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain Ras PF00071.22 KPI88028.1 - 1.6e-64 216.4 0.5 1.9e-64 216.2 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI88028.1 - 4.1e-37 127.1 0.1 6.7e-37 126.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI88028.1 - 4.8e-16 58.7 0.1 5.8e-16 58.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KPI88028.1 - 9.1e-07 28.9 0.4 0.013 15.4 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KPI88028.1 - 1.3e-06 28.0 0.1 1.6e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KPI88028.1 - 3e-05 23.5 0.1 3.9e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KPI88028.1 - 6.9e-05 22.5 0.3 0.00015 21.3 0.3 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI88028.1 - 0.00011 22.3 0.1 0.00034 20.7 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI88028.1 - 0.00073 19.1 0.0 0.0038 16.8 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 KPI88028.1 - 0.013 15.9 0.0 0.019 15.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KPI88028.1 - 0.02 14.0 3.2 0.099 11.8 0.6 2.4 1 1 1 2 2 2 0 G-protein alpha subunit AAA PF00004.29 KPI88028.1 - 0.022 15.2 0.0 0.84 10.1 0.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI88028.1 - 0.051 13.8 0.0 0.13 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI88028.1 - 0.067 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 KPI88028.1 - 0.12 11.8 0.0 0.25 10.7 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 KPI88028.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 KPI88028.1 - 0.16 12.0 0.0 0.45 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 KPI88028.1 - 0.16 12.5 0.2 0.47 11.0 0.2 1.8 1 1 0 1 1 1 0 ABC transporter MCU PF04678.13 KPI88030.1 - 7.5e-38 130.4 0.0 1.2e-37 129.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial calcium uniporter MatE PF01554.18 KPI88031.1 - 5.2e-35 120.5 29.4 1.5e-17 63.7 10.1 2.4 2 0 0 2 2 2 2 MatE FAM176 PF14851.6 KPI88031.1 - 0.0021 17.7 0.5 0.0021 17.7 0.5 1.7 2 0 0 2 2 2 1 FAM176 family DUF4666 PF15697.5 KPI88031.1 - 0.44 11.2 2.1 14 6.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) DUF2512 PF10710.9 KPI88031.1 - 3.1 7.4 9.4 0.25 11.0 1.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) LRR_6 PF13516.6 KPI88032.1 - 2e-06 27.4 6.0 0.00024 20.9 0.7 4.0 4 0 0 4 4 4 2 Leucine Rich repeat HWE_HK PF07536.14 KPI88032.1 - 0.023 15.4 0.5 0.093 13.4 0.0 2.2 2 0 0 2 2 2 0 HWE histidine kinase LRR_4 PF12799.7 KPI88032.1 - 0.028 14.8 0.4 3.4 8.2 0.1 3.2 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88032.1 - 0.53 10.1 6.2 1.6 8.6 1.7 3.5 1 1 2 3 3 3 0 Leucine rich repeat LRR_6 PF13516.6 KPI88033.1 - 0.024 14.7 0.0 12 6.3 0.0 3.1 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.6 KPI88033.1 - 0.17 11.7 1.0 0.7 9.7 0.8 2.1 2 1 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 KPI88033.1 - 0.41 11.1 2.0 0.56 10.7 0.4 2.1 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) PAP1 PF08601.10 KPI88033.1 - 2.8 7.6 5.0 0.42 10.3 1.2 1.5 2 0 0 2 2 2 0 Transcription factor PAP1 Nitroreductase PF00881.24 KPI88034.1 - 3.3e-30 105.4 0.0 4.7e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 KPI88034.1 - 0.02 14.5 0.0 0.27 10.8 0.0 2.1 2 0 0 2 2 2 0 Putative TM nitroreductase Mtc PF03820.17 KPI88037.1 - 2.4e-85 286.3 0.0 2.9e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier SHIPPO-rpt PF07004.12 KPI88038.1 - 1.6e-70 231.0 232.4 0.00024 21.8 0.2 48.5 49 0 0 49 49 49 39 Sperm-tail PG-rich repeat Cyclin PF08613.11 KPI88040.1 - 1.7e-20 74.0 0.0 1.7e-20 74.0 0.0 3.5 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 KPI88040.1 - 0.0042 16.8 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain DSPc PF00782.20 KPI88041.1 - 1.5e-21 76.6 0.0 2.6e-08 33.7 0.0 3.3 3 0 0 3 3 3 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI88041.1 - 0.013 15.0 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Vta1 PF04652.16 KPI88043.1 - 2.2e-30 105.6 0.2 3.6e-30 104.8 0.2 1.3 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 KPI88043.1 - 9.9e-12 44.4 1.6 1.8e-11 43.5 1.6 1.5 1 0 0 1 1 1 1 Vta1 C-terminal domain Wyosine_form PF08608.12 KPI88044.1 - 1.9e-20 72.9 0.6 9.2e-15 54.8 0.0 2.7 2 0 0 2 2 2 2 Wyosine base formation Radical_SAM PF04055.21 KPI88044.1 - 1.7e-18 67.6 0.0 3.5e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 KPI88044.1 - 2e-14 54.0 0.0 1e-12 48.5 0.0 2.6 2 0 0 2 2 2 1 Flavodoxin Kinesin PF00225.23 KPI88045.1 - 8.8e-80 268.1 0.1 1.4e-51 175.4 0.9 2.6 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 KPI88045.1 - 3.6e-10 40.0 0.0 4.6e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 Microtubule binding AAA_16 PF13191.6 KPI88045.1 - 0.066 13.6 0.0 0.26 11.7 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain TraC PF07820.12 KPI88045.1 - 0.38 11.1 3.7 6.6 7.1 0.2 3.9 2 0 0 2 2 2 0 TraC-like protein MAM33 PF02330.16 KPI88048.1 - 6.2e-16 59.0 0.0 1.1e-15 58.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein zf-MYND PF01753.18 KPI88049.1 - 1.2e-09 38.1 14.5 2.6e-09 37.0 14.5 1.6 1 0 0 1 1 1 1 MYND finger Got1 PF04178.12 KPI88050.1 - 6.8e-31 107.0 13.9 9.4e-31 106.6 13.9 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family Bac_export_2 PF01312.19 KPI88050.1 - 0.008 15.4 1.8 0.0084 15.4 1.8 1.1 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family DUF4064 PF13273.6 KPI88050.1 - 0.12 12.7 16.6 0.74 10.1 15.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF4191 PF13829.6 KPI88050.1 - 5.5 6.3 5.4 5.4 6.3 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) PNP_UDP_1 PF01048.20 KPI88052.1 - 1.5e-38 132.4 0.9 1.9e-38 132.1 0.9 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily FAM199X PF15814.5 KPI88056.1 - 1.9 7.4 9.9 2.7 7.0 9.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X Prominin PF05478.11 KPI88059.1 - 0.12 10.4 0.1 0.13 10.2 0.1 1.0 1 0 0 1 1 1 0 Prominin Ctr PF04145.15 KPI88060.1 - 0.058 14.0 0.1 0.079 13.6 0.1 1.3 1 1 0 1 1 1 0 Ctr copper transporter family DUF4083 PF13314.6 KPI88060.1 - 0.065 13.2 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Endonuc_Holl PF10107.9 KPI88060.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Symplekin_C PF12295.8 KPI88061.1 - 1.6e-08 34.9 0.1 8.4e-08 32.5 0.0 2.3 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal WD40 PF00400.32 KPI88063.1 - 0.00063 20.5 0.1 6 7.9 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI88063.1 - 0.0016 18.7 0.1 0.12 12.7 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cation_efflux PF01545.21 KPI88065.1 - 6.1e-40 137.1 6.8 8.2e-40 136.7 6.8 1.2 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.22 KPI88065.1 - 1.9 7.6 20.6 1.7 7.8 16.4 2.4 2 1 0 2 2 2 0 ZIP Zinc transporter DUF1106 PF06523.11 KPI88069.1 - 0.0003 20.8 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1106) DUF4150 PF13665.6 KPI88072.1 - 0.077 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4150) Lipase_3 PF01764.25 KPI88074.1 - 3.8e-38 130.5 0.0 2.8e-36 124.5 0.0 2.3 1 1 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KPI88074.1 - 0.00015 21.1 0.0 0.00029 20.2 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 KPI88074.1 - 0.00066 19.3 0.7 0.011 15.3 0.7 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 KPI88074.1 - 0.021 15.4 0.2 0.028 15.0 0.2 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 KPI88074.1 - 0.04 13.6 0.0 0.081 12.6 0.0 1.5 2 0 0 2 2 2 0 Putative esterase PRK PF00485.18 KPI88076.1 - 1.2e-39 136.1 0.0 1.6e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 KPI88076.1 - 3.1e-07 31.0 0.0 4.7e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KPI88076.1 - 0.04 13.8 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 KPI88076.1 - 0.051 13.7 0.4 0.2 11.8 0.4 2.0 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 KPI88076.1 - 0.052 13.1 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 KPI88076.1 - 0.058 13.8 0.0 0.081 13.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain CoaE PF01121.20 KPI88076.1 - 0.075 12.7 3.6 1.9 8.1 0.1 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase MobB PF03205.14 KPI88076.1 - 0.076 12.9 0.1 0.79 9.6 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 KPI88076.1 - 0.082 13.3 0.0 0.14 12.5 0.0 1.6 1 1 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 KPI88076.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KPI88076.1 - 0.14 11.3 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.20 KPI88076.1 - 0.21 11.5 0.3 11 5.8 0.1 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase ABC_tran PF00005.27 KPI88076.1 - 0.24 11.9 0.1 0.25 11.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter Fer2 PF00111.27 KPI88077.1 - 4.8e-12 45.7 0.6 4.8e-12 45.7 0.6 1.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 KPI88078.1 - 3.2e-12 46.2 0.6 4.7e-12 45.7 0.6 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NifU PF01106.17 KPI88078.1 - 0.028 14.6 0.9 0.058 13.5 0.9 1.6 1 1 0 1 1 1 0 NifU-like domain Fer2 PF00111.27 KPI88079.1 - 3.3e-10 39.8 0.2 6.3e-10 38.9 0.2 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 KPI88080.1 - 9.4e-08 31.9 0.6 1.2e-07 31.5 0.6 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 KPI88081.1 - 2.6e-11 43.3 0.5 3.5e-11 42.9 0.5 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 KPI88082.1 - 4.7e-07 29.7 1.8 7.4e-07 29.0 1.8 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Nop14 PF04147.12 KPI88083.1 - 0.027 12.7 6.3 0.041 12.1 6.3 1.2 1 0 0 1 1 1 0 Nop14-like family DUF5004 PF16395.5 KPI88083.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5004) CDC45 PF02724.14 KPI88083.1 - 4.4 5.5 6.7 7.1 4.8 6.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Oxysterol_BP PF01237.18 KPI88085.1 - 0.17 10.7 3.0 0.28 10.0 3.0 1.3 1 0 0 1 1 1 0 Oxysterol-binding protein Bud13 PF09736.9 KPI88085.1 - 2.1 8.7 10.3 4.9 7.6 10.3 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Pap_E4 PF02711.14 KPI88087.1 - 2.2 9.3 10.2 0.3 12.1 4.1 2.2 1 1 1 2 2 2 0 E4 protein SAPS PF04499.15 KPI88090.1 - 8 5.1 17.8 18 4.0 17.8 1.5 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Kinesin PF00225.23 KPI88091.1 - 0.00086 18.3 0.2 0.0017 17.3 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Baculo_p24 PF05073.12 KPI88092.1 - 0.015 15.0 0.3 0.067 13.0 0.0 2.2 3 0 0 3 3 3 0 Baculovirus P24 capsid protein Kinesin PF00225.23 KPI88095.1 - 6.6e-06 25.3 0.0 0.64 8.9 0.0 4.4 5 0 0 5 5 5 3 Kinesin motor domain Sec23_trunk PF04811.15 KPI88100.1 - 2.2e-39 135.5 0.0 1.2e-19 70.9 0.0 2.2 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KPI88100.1 - 3e-20 72.8 0.0 6e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KPI88100.1 - 1e-19 70.3 0.0 3.3e-19 68.6 0.0 2.0 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 KPI88100.1 - 3.5e-06 26.8 0.0 7.7e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 KPI88100.1 - 0.0099 15.9 11.7 0.022 14.8 11.7 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger DUF3761 PF12587.8 KPI88100.1 - 0.033 14.6 0.0 0.15 12.5 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) BRCT_2 PF16589.5 KPI88101.1 - 0.065 13.6 0.0 2.2 8.7 0.0 2.8 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Glu-tRNAGln PF02686.15 KPI88101.1 - 0.67 10.3 3.3 1.3 9.3 1.8 2.3 2 1 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit AAA_13 PF13166.6 KPI88101.1 - 0.96 8.0 7.8 1.4 7.4 7.8 1.2 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 KPI88101.1 - 1.6 7.6 13.4 2.7 6.8 13.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein LMBR1 PF04791.16 KPI88101.1 - 2.2 7.1 4.9 3.1 6.6 4.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 KPI88101.1 - 3.5 7.7 4.9 5.4 7.1 4.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 KPI88101.1 - 3.6 7.6 10.0 7 6.7 10.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 KPI88101.1 - 7 7.4 14.1 2.3 8.9 9.0 2.9 2 1 0 2 2 2 0 SlyX Iso_dh PF00180.20 KPI88102.1 - 1.9e-71 241.1 0.0 2.2e-71 240.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 KPI88102.1 - 0.12 13.1 0.6 0.32 11.8 0.1 2.0 2 0 0 2 2 2 0 Phenylalanine zipper Gluconate_2-dh3 PF13618.6 KPI88103.1 - 0.056 13.7 2.2 0.45 10.7 0.4 3.0 2 1 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 RNase_T PF00929.24 KPI88104.1 - 2.5e-09 37.9 0.0 4e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease COPI_assoc PF08507.10 KPI88105.1 - 5.6e-10 39.4 13.4 6.3e-10 39.2 13.4 1.1 1 0 0 1 1 1 1 COPI associated protein Pterin_4a PF01329.19 KPI88106.1 - 6.1e-09 35.9 0.0 3.3e-08 33.6 0.0 2.0 1 1 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase DUF5073 PF16817.5 KPI88106.1 - 0.079 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5073) IFT57 PF10498.9 KPI88107.1 - 0.01 14.9 1.0 0.01 14.9 1.0 3.0 3 1 0 3 3 3 1 Intra-flagellar transport protein 57 APG6_N PF17675.1 KPI88107.1 - 0.014 15.9 4.0 0.014 15.9 4.0 3.9 3 1 0 3 3 3 0 Apg6 coiled-coil region DUF3450 PF11932.8 KPI88107.1 - 0.3 10.4 23.2 0.33 10.2 2.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) IFT20 PF14931.6 KPI88107.1 - 2 8.6 20.3 0.053 13.7 4.3 3.4 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 Spc7 PF08317.11 KPI88107.1 - 3.5 6.4 21.5 1 8.2 0.3 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein RasGAP_C PF03836.15 KPI88107.1 - 5.2 7.2 8.7 3.2 7.9 0.9 3.2 2 1 1 3 3 3 0 RasGAP C-terminus XAP5 PF04921.14 KPI88107.1 - 9.4 6.0 9.1 11 5.7 2.2 2.7 2 1 0 2 2 2 0 XAP5, circadian clock regulator Amastin PF07344.11 KPI88108.1 - 2.6e-42 144.3 23.6 3.2e-27 95.3 8.2 2.3 2 0 0 2 2 2 2 Amastin surface glycoprotein COX4_pro_2 PF07835.12 KPI88108.1 - 0.081 13.0 2.2 0.25 11.5 0.0 3.0 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Amastin PF07344.11 KPI88109.1 - 8.3e-40 136.2 21.7 1.4e-23 83.4 6.9 2.2 2 0 0 2 2 2 2 Amastin surface glycoprotein FAM176 PF14851.6 KPI88110.1 - 0.047 13.3 0.1 0.072 12.7 0.1 1.2 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 KPI88110.1 - 0.072 13.5 8.2 0.073 13.5 6.6 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SoxE PF06525.11 KPI88110.1 - 0.11 11.9 0.2 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 Sulfocyanin (SoxE) domain MRNIP PF15749.5 KPI88110.1 - 0.49 11.1 2.3 6.8 7.5 0.2 2.3 2 0 0 2 2 2 0 MRN-interacting protein PBP1_TM PF14812.6 KPI88110.1 - 5.4 7.5 8.7 2.9 8.3 6.8 1.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4757 PF15949.5 KPI88111.1 - 0.23 11.9 0.5 0.41 11.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4757) Nop PF01798.18 KPI88112.1 - 6.8e-79 264.6 0.0 9.1e-79 264.1 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KPI88112.1 - 4.5e-16 59.0 0.0 1.3e-15 57.5 0.0 1.9 1 0 0 1 1 1 1 NOP5NT (NUC127) domain PH PF00169.29 KPI88113.1 - 1.1e-08 35.5 0.1 2.9e-08 34.2 0.0 1.8 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 KPI88113.1 - 0.0041 17.5 0.2 0.053 13.9 0.2 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain Pkinase PF00069.25 KPI88114.1 - 5.6e-53 180.0 0.0 7.5e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88114.1 - 6.4e-26 91.2 0.1 9.5e-26 90.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KPI88114.1 - 7.1e-07 28.5 0.9 1.1e-06 27.9 0.9 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KPI88114.1 - 1.9e-05 24.1 0.8 1.9e-05 24.1 0.8 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI88114.1 - 0.00022 21.2 0.7 0.00022 21.2 0.7 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI88114.1 - 0.025 13.4 0.4 0.041 12.7 0.4 1.3 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 KPI88114.1 - 0.084 12.5 0.4 0.19 11.3 0.4 1.6 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 KPI88114.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.5 1 1 0 1 1 1 0 Kinase-like MORN PF02493.20 KPI88115.1 - 3.4e-17 61.2 21.2 1.9e-06 27.4 0.5 4.8 5 0 0 5 5 5 4 MORN repeat ECR1_N PF14382.6 KPI88115.1 - 4.9 7.0 7.5 6 6.8 0.3 3.3 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region PDZ_6 PF17820.1 KPI88116.1 - 2.6e-09 36.8 0.3 8e-09 35.2 0.3 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KPI88116.1 - 1.6e-06 28.4 0.0 3.3e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KPI88116.1 - 5.7e-05 23.4 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Syntaxin-6_N PF09177.11 KPI88116.1 - 0.16 12.6 0.4 1 10.0 0.2 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF842 PF05811.13 KPI88116.1 - 0.49 10.1 5.4 1.6 8.5 2.5 2.7 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) CMV_1a PF12467.8 KPI88116.1 - 8.9 6.6 6.2 1.3 9.3 0.5 2.6 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family LRR_8 PF13855.6 KPI88117.1 - 3.8e-11 42.6 8.4 7.4e-09 35.2 5.2 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI88117.1 - 7.7e-10 38.9 10.8 3.1e-06 27.4 1.4 3.3 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI88117.1 - 0.005 16.3 0.1 0.0096 15.4 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 KPI88117.1 - 0.0051 17.2 10.6 0.81 10.5 0.7 4.7 4 1 0 4 4 4 1 Leucine Rich Repeat MNNL PF07657.13 KPI88117.1 - 0.05 13.6 0.5 0.096 12.7 0.5 1.5 1 0 0 1 1 1 0 N terminus of Notch ligand GDA1_CD39 PF01150.17 KPI88118.1 - 5.9e-53 180.0 0.0 1.4e-52 178.8 0.0 1.6 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 KPI88118.1 - 2.7e-05 23.7 0.0 8.4e-05 22.1 0.0 1.7 2 0 0 2 2 2 1 Ppx/GppA phosphatase family NUDE_C PF04880.13 KPI88118.1 - 0.023 15.2 0.8 0.056 13.9 0.8 1.7 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Osmo_CC PF08946.10 KPI88118.1 - 0.1 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil SPO11_like PF03533.14 KPI88119.1 - 0.015 15.4 0.2 0.078 13.1 0.2 2.3 1 0 0 1 1 1 0 SPO11 homologue tRNA-synt_1d PF00750.19 KPI88119.1 - 0.072 12.0 1.4 0.11 11.4 1.4 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (R) Macoilin PF09726.9 KPI88119.1 - 0.073 11.6 14.5 0.023 13.3 3.3 2.3 2 0 0 2 2 2 0 Macoilin family LXG PF04740.12 KPI88119.1 - 0.46 10.2 7.7 0.049 13.3 3.0 1.7 2 0 0 2 2 2 0 LXG domain of WXG superfamily HAUS-augmin3 PF14932.6 KPI88119.1 - 0.92 9.0 21.5 0.038 13.6 10.7 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Tektin PF03148.14 KPI88119.1 - 0.93 8.2 30.5 0.066 12.0 19.0 3.2 2 1 1 3 3 3 0 Tektin family TMPIT PF07851.13 KPI88119.1 - 1.1 8.4 13.0 0.23 10.6 5.5 2.2 2 0 0 2 2 2 0 TMPIT-like protein DUF3584 PF12128.8 KPI88119.1 - 2 5.8 27.6 0.65 7.4 14.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 KPI88119.1 - 2.2 7.1 32.1 0.81 8.5 18.8 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 KPI88119.1 - 4.6 7.8 38.8 0.11 13.0 17.6 3.0 2 1 1 3 3 3 0 Apg6 coiled-coil region Baculo_PEP_C PF04513.12 KPI88119.1 - 8.5 6.4 8.6 4.5 7.3 2.1 3.0 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DEAD PF00270.29 KPI88121.1 - 4.6e-20 72.1 0.2 1e-15 57.9 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88121.1 - 2.3e-19 69.8 0.2 1.5e-17 63.9 0.3 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ANF_receptor PF01094.28 KPI88121.1 - 0.18 10.8 1.8 5.6 6.0 0.2 2.2 2 0 0 2 2 2 0 Receptor family ligand binding region DUF4349 PF14257.6 KPI88122.1 - 0.0037 16.7 7.2 0.069 12.6 0.7 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4349) Thioredoxin_11 PF18078.1 KPI88122.1 - 0.17 12.0 0.1 0.56 10.3 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like SNTX domain DUF4407 PF14362.6 KPI88122.1 - 0.93 8.8 8.4 1.6 8.0 8.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PSP1 PF04468.12 KPI88123.1 - 2.6e-21 75.7 0.1 4.1e-21 75.1 0.1 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region WD40 PF00400.32 KPI88124.1 - 3.6e-30 103.6 34.0 1.1e-07 32.5 0.5 8.2 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI88124.1 - 1.4e-06 28.5 0.3 0.42 11.0 0.0 4.5 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI88124.1 - 0.011 14.7 2.2 2.3 7.1 0.2 3.4 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SRP40_C PF05022.12 KPI88125.1 - 3.6e-13 50.2 0.4 4.7e-13 49.8 0.4 1.2 1 0 0 1 1 1 1 SRP40, C-terminal domain MMR_HSR1 PF01926.23 KPI88126.1 - 9.1e-18 64.4 0.1 7.3e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI88126.1 - 4.5e-10 39.3 1.0 1.9e-08 34.0 0.6 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KPI88126.1 - 7.4e-05 22.7 0.6 0.00089 19.2 0.6 2.1 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 KPI88126.1 - 0.00028 20.5 0.1 0.0026 17.3 0.0 2.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 KPI88126.1 - 0.0019 18.3 0.5 0.027 14.5 0.4 2.5 2 1 1 3 3 3 1 Dynamin family AAA_18 PF13238.6 KPI88126.1 - 0.012 16.1 0.0 0.056 14.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 KPI88126.1 - 0.061 12.3 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HSP90 PF00183.18 KPI88127.1 - 5.8e-96 322.4 1.8 4.7e-94 316.2 0.2 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 KPI88127.1 - 2.3e-11 43.7 0.1 6.6e-11 42.2 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KPI88127.1 - 5.9e-07 30.0 0.1 1.3e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DPRP PF04244.13 KPI88127.1 - 0.013 15.4 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein GRASP55_65 PF04495.14 KPI88128.1 - 1.3e-44 151.9 0.0 1.7e-39 135.3 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 KPI88128.1 - 0.038 14.3 0.0 1 9.7 0.0 2.3 2 0 0 2 2 2 0 PDZ domain NCA2 PF08637.10 KPI88131.1 - 2.7e-33 115.4 0.0 2.3e-23 82.8 0.0 2.2 2 0 0 2 2 2 2 ATP synthase regulation protein NCA2 CoA_trans PF01144.23 KPI88132.1 - 1.1e-95 319.2 2.1 4.1e-58 196.3 0.3 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Bap31_Bap29_C PF18035.1 KPI88133.1 - 0.34 10.9 7.8 0.036 14.1 1.7 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Kelch_3 PF13415.6 KPI88133.1 - 0.67 10.3 9.7 9.7 6.6 0.4 4.2 3 0 0 3 3 3 0 Galactose oxidase, central domain CDC45 PF02724.14 KPI88134.1 - 4.2e-81 273.1 0.0 5.7e-81 272.7 0.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Dala_Dala_lig_C PF07478.13 KPI88135.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Epimerase PF01370.21 KPI88136.1 - 9.3e-40 136.6 0.0 1.2e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KPI88136.1 - 1.7e-35 123.0 0.0 1e-33 117.1 0.0 2.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 KPI88136.1 - 2.4e-13 49.9 0.0 1.9e-12 46.9 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KPI88136.1 - 1.3e-11 44.0 0.0 6.9e-11 41.7 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KPI88136.1 - 1.2e-08 34.5 0.0 7.8e-08 31.8 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 KPI88136.1 - 2.2e-05 23.7 0.0 7.2e-05 22.0 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 KPI88136.1 - 3.2e-05 23.9 0.0 0.00013 21.9 0.0 1.9 2 0 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 KPI88136.1 - 0.034 14.4 0.1 0.072 13.3 0.1 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain YAcAr PF10686.9 KPI88136.1 - 0.051 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family Semialdhyde_dh PF01118.24 KPI88136.1 - 0.053 14.0 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 KPI88136.1 - 0.054 13.4 0.0 2.5 8.0 0.1 2.2 2 0 0 2 2 2 0 NAD(P)H-binding DUF1800 PF08811.11 KPI88136.1 - 0.21 10.6 0.0 0.33 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) zf-MYND PF01753.18 KPI88137.1 - 3e-07 30.4 11.0 3e-07 30.4 11.0 2.4 3 0 0 3 3 3 1 MYND finger BLOC1_2 PF10046.9 KPI88138.1 - 0.013 15.8 2.4 0.013 15.8 2.4 6.5 2 2 4 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.11 KPI88138.1 - 2.2 8.4 103.0 0.084 13.1 15.4 5.2 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) MAD PF05557.13 KPI88138.1 - 2.6 6.3 70.4 4.4 5.5 17.4 3.2 1 1 2 3 3 3 0 Mitotic checkpoint protein Terminase_6 PF03237.15 KPI88138.1 - 5.6 6.6 8.9 0.15 11.7 0.3 2.7 2 1 0 2 2 2 0 Terminase-like family Glyco_hydro_85 PF03644.13 KPI88139.1 - 4.3e-80 269.4 0.0 6.2e-80 268.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Peptidase_C97 PF05903.14 KPI88139.1 - 5e-27 94.6 0.0 1.1e-26 93.5 0.0 1.6 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUB PF09409.10 KPI88139.1 - 3.9e-12 45.9 0.0 7.5e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 PUB domain DUF3421 PF11901.8 KPI88139.1 - 2.9e-07 30.5 0.7 0.015 15.3 0.1 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) Tudor-knot PF11717.8 KPI88139.1 - 0.16 11.9 0.0 22 5.0 0.0 2.5 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Baculo_IE-1 PF05290.11 KPI88140.1 - 0.015 15.2 2.8 0.026 14.4 2.8 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Lzipper-MIP1 PF14389.6 KPI88140.1 - 0.029 14.6 1.5 1.6 9.1 0.1 2.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 zf-C3HC4_3 PF13920.6 KPI88140.1 - 0.52 10.2 12.8 0.91 9.4 12.8 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KPI88140.1 - 0.89 9.4 11.4 1.7 8.5 11.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain CFAP91 PF14738.6 KPI88143.1 - 6e-43 146.5 5.6 6e-43 146.5 5.6 2.9 3 1 0 3 3 3 1 Cilia- and flagella-associated protein 91 USP8_dimer PF08969.11 KPI88143.1 - 0.29 11.3 2.5 0.83 9.8 0.4 2.6 2 0 0 2 2 2 0 USP8 dimerisation domain DUF1279 PF06916.13 KPI88144.1 - 0.025 15.1 0.2 0.054 14.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) AflR PF08493.10 KPI88145.1 - 8.1 5.8 9.4 36 3.7 8.7 2.2 1 1 0 1 1 1 0 Aflatoxin regulatory protein Lyx_isomer PF07385.12 KPI88146.1 - 0.092 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 D-lyxose isomerase Pox_A_type_inc PF04508.12 KPI88149.1 - 0.29 11.1 3.3 0.17 11.8 0.6 2.1 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Tup_N PF08581.10 KPI88149.1 - 1.2 9.4 5.2 21 5.5 0.4 2.8 2 0 0 2 2 2 0 Tup N-terminal Acid_PPase PF12689.7 KPI88150.1 - 1.7e-47 161.4 0.0 2e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase NIF PF03031.18 KPI88150.1 - 0.0033 17.2 0.0 0.0043 16.8 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.26 KPI88150.1 - 0.043 14.1 0.1 0.052 13.8 0.1 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88150.1 - 0.078 13.4 0.0 0.24 11.8 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Dynein_heavy PF03028.15 KPI88151.1 - 1.7e-06 28.1 0.0 3.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain WD40 PF00400.32 KPI88151.1 - 0.00036 21.3 9.0 6.9 7.7 0.4 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.6 KPI88151.1 - 0.13 12.8 7.2 24 5.6 0.2 4.9 4 0 0 4 4 4 0 PQQ-like domain Kinesin PF00225.23 KPI88152.1 - 5.1e-80 268.9 0.0 9.3e-80 268.0 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI88152.1 - 5.8e-21 75.0 0.0 1.2e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Peptidase_C2 PF00648.21 KPI88153.1 - 1.5e-54 185.1 0.0 2.2e-54 184.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI88153.1 - 2.2e-33 114.7 0.2 4.6e-33 113.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Calpain_III PF01067.22 KPI88153.1 - 0.072 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Calpain large subunit, domain III Peptidase_C2 PF00648.21 KPI88154.1 - 2e-45 155.1 0.0 2.9e-45 154.6 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI88154.1 - 9.2e-25 87.0 0.0 1.8e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.21 KPI88155.1 - 2.6e-08 33.3 0.0 2.7e-08 33.2 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI88157.1 - 1.5e-24 86.4 0.0 1.8e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF4855 PF16147.5 KPI88157.1 - 0.032 13.3 0.1 0.042 12.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4855) IFS PF16718.5 KPI88157.1 - 0.12 12.5 0.2 0.16 12.1 0.2 1.1 1 0 0 1 1 1 0 Immunity factor for SPN DUF1935 PF09149.10 KPI88158.1 - 1.3e-26 93.0 0.0 1.6e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Raptor_N PF14538.6 KPI88159.1 - 7.9e-11 42.1 0.0 4.2e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain DUF1935 PF09149.10 KPI88160.1 - 4.8e-30 104.0 0.0 9.8e-30 103.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF1935 PF09149.10 KPI88161.1 - 7.4e-05 23.1 0.0 0.69 10.3 0.0 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF1935) DUF1935 PF09149.10 KPI88162.1 - 3.5e-07 30.5 0.1 5.3e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF3408 PF11888.8 KPI88162.1 - 0.065 13.4 0.6 0.095 12.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF1935 PF09149.10 KPI88163.1 - 2.5e-29 101.7 0.0 3.5e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) CRISPR_assoc PF08798.11 KPI88163.1 - 0.097 12.8 0.0 0.15 12.2 0.0 1.3 1 1 0 1 1 1 0 CRISPR associated protein NAP PF00956.18 KPI88164.1 - 7.9e-12 44.9 3.5 1.3e-08 34.4 3.5 2.3 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) GSIII_N PF12437.8 KPI88164.1 - 0.23 11.1 1.0 0.31 10.7 0.0 1.7 2 0 0 2 2 2 0 Glutamine synthetase type III N terminal DUF4363 PF14276.6 KPI88164.1 - 1.5 8.9 6.6 0.32 11.1 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) DUF1935 PF09149.10 KPI88165.1 - 1.3e-33 115.4 0.0 1.5e-33 115.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF1935 PF09149.10 KPI88166.1 - 2.1e-40 137.3 0.2 2.5e-40 137.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) DUF960 PF06124.11 KPI88166.1 - 0.07 13.8 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Staphylococcal protein of unknown function (DUF960) Pkinase PF00069.25 KPI88168.1 - 1e-31 110.3 0.0 1.4e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88168.1 - 1.6e-19 70.2 0.0 2.2e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI88168.1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI88168.1 - 0.026 13.3 0.0 0.04 12.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Adaptin_N PF01602.20 KPI88169.1 - 1.3e-63 215.4 8.0 2e-63 214.8 8.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 KPI88169.1 - 1.3e-48 164.2 0.0 3.1e-48 163.0 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 KPI88169.1 - 4.4e-42 143.3 0.0 2.3e-41 141.0 0.0 2.1 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 KPI88169.1 - 1.9e-08 34.6 2.8 0.04 14.3 0.0 4.8 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 KPI88169.1 - 8.5e-06 25.6 4.3 0.22 11.9 0.0 5.3 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 KPI88169.1 - 0.00018 21.6 8.9 0.001 19.2 0.1 4.0 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DUF1981 PF09324.10 KPI88169.1 - 0.086 12.7 0.0 0.28 11.1 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) Arm PF00514.23 KPI88169.1 - 0.11 12.6 2.2 6.1 7.0 0.1 3.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat LST1 PF05083.13 KPI88170.1 - 0.06 13.6 0.0 0.18 12.1 0.0 1.8 1 0 0 1 1 1 0 LST-1 protein PUF PF00806.19 KPI88171.1 - 1.2e-22 78.3 0.0 0.00012 21.5 0.0 4.5 4 0 0 4 4 4 4 Pumilio-family RNA binding repeat MA3 PF02847.17 KPI88171.1 - 0.037 14.0 0.1 0.25 11.3 0.0 2.1 1 1 1 2 2 2 0 MA3 domain Collagen_mid PF15984.5 KPI88171.1 - 0.059 13.1 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 Bacterial collagen, middle region PUF PF00806.19 KPI88172.1 - 5.2e-13 47.9 0.2 4.8e-05 22.8 0.0 3.5 3 0 0 3 3 3 3 Pumilio-family RNA binding repeat N_formyltrans_C PF18216.1 KPI88173.1 - 0.015 14.9 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain FAM76 PF16046.5 KPI88173.1 - 5.7 6.2 5.5 9.4 5.5 5.5 1.2 1 0 0 1 1 1 0 FAM76 protein DASH_Spc19 PF08287.11 KPI88174.1 - 9.8 6.1 21.6 2.1 8.2 12.2 2.5 2 0 0 2 2 2 0 Spc19 Arm PF00514.23 KPI88175.1 - 3.8e-33 112.5 18.8 1.7e-08 34.2 0.0 8.7 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KPI88175.1 - 1.3e-17 62.3 9.3 0.014 15.6 0.1 7.9 8 0 0 8 8 8 5 HEAT repeat HEAT_EZ PF13513.6 KPI88175.1 - 1.1e-15 57.7 13.7 0.0051 17.3 0.6 6.3 5 1 1 6 6 6 5 HEAT-like repeat HEAT_2 PF13646.6 KPI88175.1 - 1.7e-14 53.9 14.1 0.0022 18.4 0.1 5.5 2 2 4 6 6 6 6 HEAT repeats Cnd1 PF12717.7 KPI88175.1 - 4.1e-12 46.4 0.2 0.0015 18.6 0.0 3.9 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KPI88175.1 - 1.5e-09 37.0 0.9 1.1e-07 30.8 1.0 2.9 2 1 1 3 3 3 2 Adaptin N terminal region DNA_alkylation PF08713.11 KPI88175.1 - 4.9e-08 33.0 0.2 0.027 14.2 0.0 4.1 2 1 2 4 4 4 2 DNA alkylation repair enzyme CLASP_N PF12348.8 KPI88175.1 - 0.00015 21.5 0.4 0.29 10.7 0.0 2.7 1 1 1 2 2 2 2 CLASP N terminal HEAT_UF PF18817.1 KPI88175.1 - 0.00083 19.6 0.1 0.97 9.8 0.0 3.7 4 0 0 4 4 4 1 Repeat of uncharacterized protein PH0542 Mo25 PF08569.11 KPI88175.1 - 0.0016 17.8 0.1 0.64 9.3 0.1 2.4 1 1 0 2 2 2 2 Mo25-like V-ATPase_H_C PF11698.8 KPI88175.1 - 0.0085 16.2 0.7 1.9 8.6 0.2 3.4 3 1 1 4 4 4 2 V-ATPase subunit H HEAT_PBS PF03130.16 KPI88175.1 - 0.0088 16.6 15.3 0.74 10.7 1.6 6.0 6 1 0 6 6 5 2 PBS lyase HEAT-like repeat Proteasom_PSMB PF10508.9 KPI88175.1 - 0.011 14.2 1.4 1.1 7.7 0.3 2.7 1 1 2 3 3 3 0 Proteasome non-ATPase 26S subunit Vac14_Fab1_bd PF12755.7 KPI88175.1 - 0.042 14.4 0.1 0.86 10.2 0.0 3.0 1 1 3 4 4 4 0 Vacuolar 14 Fab1-binding region API5 PF05918.11 KPI88175.1 - 0.37 9.6 1.8 13 4.4 0.0 3.0 3 1 1 4 4 4 0 Apoptosis inhibitory protein 5 (API5) SET PF00856.28 KPI88178.1 - 4.9e-06 27.0 0.0 1.3e-05 25.7 0.0 1.5 1 1 0 1 1 1 1 SET domain Lipase_3 PF01764.25 KPI88179.1 - 3.6e-17 62.6 0.0 3.5e-16 59.3 0.0 2.5 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 KPI88179.1 - 0.0012 19.4 4.4 0.0013 19.4 2.2 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KPI88179.1 - 0.0016 18.2 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_3 PF07859.13 KPI88179.1 - 0.0057 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2974 PF11187.8 KPI88179.1 - 0.031 13.8 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) ubiquitin PF00240.23 KPI88181.1 - 0.001 18.8 0.0 0.48 10.2 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin family DUF4404 PF14357.6 KPI88181.1 - 1.1 10.0 4.9 0.5 11.0 2.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) IF4E PF01652.18 KPI88182.1 - 1.1e-07 31.8 0.0 1.4e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E CRAL_TRIO PF00650.20 KPI88183.1 - 5.2e-24 84.8 0.0 8.4e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CAP_GLY PF01302.25 KPI88183.1 - 4e-14 52.4 0.3 7.9e-14 51.4 0.3 1.5 1 0 0 1 1 1 1 CAP-Gly domain CRAL_TRIO_2 PF13716.6 KPI88183.1 - 0.0001 22.5 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KPI88183.1 - 0.046 13.9 0.2 0.11 12.7 0.2 1.6 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain WD40 PF00400.32 KPI88184.1 - 2.9e-09 37.4 6.8 0.079 13.9 0.0 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KPI88184.1 - 0.0061 15.6 0.4 1.9 7.4 0.0 3.0 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein GTP_EFTU PF00009.27 KPI88185.1 - 3.1e-61 206.3 0.0 5.4e-61 205.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 KPI88185.1 - 4.3e-26 90.8 0.0 1.2e-25 89.4 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KPI88185.1 - 4.2e-20 71.6 0.0 1.1e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 KPI88185.1 - 4.2e-18 65.3 0.0 1.1e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 KPI88185.1 - 2.8e-07 30.8 0.0 9.6e-07 29.1 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KPI88185.1 - 3.9e-05 23.5 0.1 0.00014 21.7 0.1 1.9 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 KPI88185.1 - 0.0031 17.6 0.0 0.007 16.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4132 PF13569.6 KPI88185.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) AIG1 PF04548.16 KPI88185.1 - 0.056 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 AIG1 family SUI1 PF01253.22 KPI88185.1 - 0.089 13.3 0.1 29 5.3 0.0 2.7 2 0 0 2 2 2 0 Translation initiation factor SUI1 DUF148 PF02520.17 KPI88185.1 - 0.13 12.4 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 Spc7 PF08317.11 KPI88186.1 - 0.87 8.4 39.7 0.065 12.1 11.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein HOOK PF05622.12 KPI88186.1 - 1.8 6.7 39.7 3.2 5.8 39.8 1.4 1 1 0 1 1 1 0 HOOK protein DUF4201 PF13870.6 KPI88186.1 - 4.4 7.0 35.1 3.5 7.3 29.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 KPI88186.1 - 7.1 5.9 30.7 2.4e+02 0.8 30.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 KPI88186.1 - 7.6 6.8 29.0 3.7 7.9 0.2 4.3 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) YabA PF06156.13 KPI88186.1 - 8.6 7.1 28.6 0.81 10.4 5.4 3.8 2 1 1 3 3 3 0 Initiation control protein YabA Pkinase PF00069.25 KPI88187.1 - 2.4e-78 263.1 0.0 2.8e-78 262.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88187.1 - 1.5e-34 119.5 0.0 2.9e-34 118.5 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KPI88187.1 - 0.0019 18.2 0.5 0.054 13.4 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI88187.1 - 0.0038 16.2 0.0 0.02 13.8 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KPI88187.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 KPI88187.1 - 0.2 11.0 0.0 15 4.8 0.0 2.4 2 1 0 2 2 2 0 Kinase-like ubiquitin PF00240.23 KPI88188.1 - 1.4e-15 56.8 0.1 2.3e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 KPI88188.1 - 2.6e-07 30.4 1.1 9.5e-07 28.6 1.1 2.1 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 KPI88188.1 - 0.00014 21.7 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 KPI88188.1 - 0.044 13.8 0.6 0.08 12.9 0.1 1.6 2 0 0 2 2 2 0 HOIP UBA domain pair Ubiquitin_2 PF14560.6 KPI88188.1 - 0.072 13.6 0.0 0.18 12.3 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain RNA_pol_Rpb5_C PF01191.19 KPI88188.1 - 0.1 12.5 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Rad60-SLD_2 PF13881.6 KPI88188.1 - 0.18 11.9 0.1 0.53 10.4 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PP2C PF00481.21 KPI88190.1 - 1.3e-72 244.5 0.4 1.6e-72 244.2 0.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KPI88190.1 - 0.00022 21.2 0.0 0.025 14.5 0.0 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KPI88190.1 - 0.0075 15.9 0.2 0.01 15.5 0.2 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C APG6_N PF17675.1 KPI88191.1 - 0.025 15.1 4.3 0.04 14.5 4.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_23 PF13476.6 KPI88191.1 - 0.027 15.0 0.4 0.033 14.7 0.4 1.1 1 0 0 1 1 1 0 AAA domain KELK PF15796.5 KPI88191.1 - 0.21 12.1 4.5 0.33 11.4 4.5 1.3 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase CCDC-167 PF15188.6 KPI88191.1 - 0.28 11.6 4.1 0.3 11.5 2.9 1.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Mito_carr PF00153.27 KPI88192.1 - 9.9e-90 294.7 19.4 1.6e-19 69.6 0.0 6.3 5 1 1 6 6 6 6 Mitochondrial carrier protein Serine_protease PF18405.1 KPI88192.1 - 0.0051 16.0 6.9 3.6 6.7 0.0 5.1 4 2 0 5 5 5 2 Gammaproteobacterial serine protease DnaJ PF00226.31 KPI88193.1 - 2.4e-20 72.4 0.6 5.8e-20 71.2 0.6 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 KPI88193.1 - 5.9e-16 57.2 24.4 0.00088 19.2 0.9 7.8 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 KPI88193.1 - 2.1e-13 49.7 20.8 1.3e-06 27.9 2.7 6.3 6 1 1 7 7 7 3 TPR repeat TPR_1 PF00515.28 KPI88193.1 - 2.1e-12 46.3 25.3 0.0006 19.5 0.6 7.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 KPI88193.1 - 1.8e-10 40.2 10.1 0.047 13.9 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 KPI88193.1 - 8.5e-10 39.0 27.0 0.011 16.3 2.5 6.6 4 3 3 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 KPI88193.1 - 6.7e-09 35.5 11.4 0.017 15.5 0.3 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI88193.1 - 7.9e-07 29.6 22.4 0.01 16.4 2.8 6.3 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI88193.1 - 2.6e-05 24.4 17.6 0.023 15.0 1.3 5.8 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI88193.1 - 5.4e-05 23.7 25.5 0.2 12.6 0.2 7.3 6 1 2 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI88193.1 - 0.00058 20.0 13.8 0.71 10.1 1.4 5.4 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI88193.1 - 0.0011 18.9 5.4 3.3 8.0 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI88193.1 - 0.0018 18.4 10.7 0.096 12.9 0.1 4.9 2 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 KPI88193.1 - 0.011 16.2 10.8 3.9 7.9 1.4 4.9 3 2 2 5 5 5 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 KPI88193.1 - 0.082 13.0 3.0 0.44 10.7 0.3 3.6 4 1 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 KPI88193.1 - 0.34 10.4 2.2 4.3 6.9 0.1 3.1 3 0 0 3 3 3 0 SHNi-TPR zf-C2HC_2 PF13913.6 KPI88194.1 - 3.7e-15 55.4 6.0 4.4e-10 39.2 1.1 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.6 KPI88194.1 - 0.018 15.5 1.4 6.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 KPI88194.1 - 0.02 14.9 3.2 1.1 9.3 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI88194.1 - 0.079 13.5 2.4 6.8 7.3 1.0 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KPI88194.1 - 0.08 13.8 4.1 6.9 7.8 2.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger FAM76 PF16046.5 KPI88194.1 - 0.19 11.0 1.5 0.29 10.4 1.5 1.2 1 0 0 1 1 1 0 FAM76 protein zf-ANAPC11 PF12861.7 KPI88195.1 - 0.028 14.5 1.0 0.048 13.7 1.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Dus PF01207.17 KPI88196.1 - 1.9e-35 122.4 1.2 1.7e-29 102.9 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) Sec1 PF00995.23 KPI88197.1 - 4.4e-105 353.1 0.0 5.7e-105 352.7 0.0 1.1 1 0 0 1 1 1 1 Sec1 family YPEB PF14620.6 KPI88198.1 - 0.13 11.6 0.1 0.2 11.0 0.1 1.1 1 0 0 1 1 1 0 YpeB sporulation GvpG PF05120.12 KPI88199.1 - 0.097 12.7 2.0 0.18 11.9 0.3 2.3 2 0 0 2 2 2 0 Gas vesicle protein G TFIIA_gamma_C PF02751.14 KPI88200.1 - 2.9e-06 27.3 0.0 5.9e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 KPI88200.1 - 0.00044 20.2 0.0 0.00081 19.4 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Aa_trans PF01490.18 KPI88201.1 - 5e-61 206.6 26.8 5.8e-61 206.4 26.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI88201.1 - 1.3e-07 31.0 16.6 1.3e-07 31.0 16.6 2.2 1 1 1 2 2 2 1 Tryptophan/tyrosine permease family TMEM70 PF06979.12 KPI88201.1 - 0.49 10.8 14.9 0.43 11.0 0.2 3.9 2 2 2 4 4 4 0 Assembly, mitochondrial proton-transport ATP synth complex TBCA PF02970.16 KPI88202.1 - 0.3 11.4 5.0 0.48 10.8 5.0 1.3 1 0 0 1 1 1 0 Tubulin binding cofactor A PDZ_2 PF13180.6 KPI88203.1 - 0.0042 17.4 0.0 0.0094 16.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF4423 PF14394.6 KPI88203.1 - 0.012 15.4 3.6 0.012 15.4 3.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) PDZ PF00595.24 KPI88203.1 - 0.017 15.5 0.0 0.055 13.8 0.0 1.9 2 0 0 2 2 2 0 PDZ domain DUF4495 PF14906.6 KPI88203.1 - 0.017 14.2 3.1 0.56 9.2 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4495) PhaP_Bmeg PF09602.10 KPI88203.1 - 0.12 12.2 2.4 0.21 11.5 2.4 1.3 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) YtzH PF14165.6 KPI88204.1 - 0.11 13.0 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 YtzH-like protein Peptidase_S24 PF00717.23 KPI88205.1 - 2.9e-08 33.5 0.0 4.4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 KPI88205.1 - 0.046 13.5 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 Signal peptidase, peptidase S26 DB_JBP1 PF18526.1 KPI88206.1 - 4.3e-05 23.5 0.0 9.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Thymine dioxygenase JBP1 DNA-binding domain Macoilin PF09726.9 KPI88206.1 - 5.1 5.5 4.3 7.4 5.0 4.3 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 KPI88207.1 - 0.9 9.5 13.6 1 9.3 13.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BES1_N PF05687.13 KPI88207.1 - 1.7 9.0 0.1 1.7 9.0 0.1 2.5 2 1 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal PIP5K PF01504.18 KPI88208.1 - 6e-55 186.4 0.0 7.7e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EMC3_TMCO1 PF01956.16 KPI88209.1 - 5e-48 163.0 4.9 7.2e-48 162.5 4.9 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like RNase_HII PF01351.18 KPI88211.1 - 1.4e-19 70.8 0.0 7.6e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease HII Ank_4 PF13637.6 KPI88212.1 - 1.6e-09 38.1 2.2 5.5e-06 26.8 0.5 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI88212.1 - 8e-09 35.0 5.2 0.0013 19.0 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 KPI88212.1 - 8.1e-09 36.0 3.9 9e-05 23.0 1.5 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI88212.1 - 1.7e-07 31.4 1.7 0.00031 21.0 0.3 3.1 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KPI88212.1 - 5.4e-07 29.8 7.4 0.00021 21.6 0.2 4.4 5 0 0 5 5 5 2 Ankyrin repeat Tropomyosin PF00261.20 KPI88212.1 - 0.02 14.2 5.1 0.029 13.8 5.1 1.1 1 0 0 1 1 1 0 Tropomyosin SOAR PF16533.5 KPI88212.1 - 0.054 13.5 1.1 0.22 11.5 0.7 2.1 1 1 1 2 2 2 0 STIM1 Orai1-activating region PRIMA1 PF16101.5 KPI88212.1 - 0.13 12.3 2.4 0.26 11.3 2.4 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF3135 PF11333.8 KPI88212.1 - 0.33 11.2 2.8 0.24 11.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Mito_fiss_reg PF05308.11 KPI88212.1 - 0.35 10.9 6.8 0.9 9.6 6.8 1.6 1 1 0 1 1 1 0 Mitochondrial fission regulator Proteasome PF00227.26 KPI88213.1 - 1e-29 103.4 0.0 1.4e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit ESCRT-II PF05871.12 KPI88214.1 - 1e-14 55.0 0.0 2.7e-14 53.6 0.0 1.6 1 1 0 1 1 1 1 ESCRT-II complex subunit NUDIX PF00293.28 KPI88215.1 - 2.5e-10 40.5 0.0 3.8e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain TFIIS_M PF07500.14 KPI88217.1 - 1.7e-07 31.7 1.6 2.7e-07 31.0 1.6 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain zf-C2HE PF16278.5 KPI88217.1 - 0.31 11.5 2.4 0.56 10.7 0.6 2.3 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger GOLD_2 PF13897.6 KPI88217.1 - 4.7 7.7 6.5 1.4 9.4 0.7 2.2 2 1 0 2 2 2 0 Golgi-dynamics membrane-trafficking CH PF00307.31 KPI88218.1 - 0.068 13.3 0.0 28 4.9 0.0 3.2 3 0 0 3 3 3 0 Calponin homology (CH) domain FGGY_N PF00370.21 KPI88219.1 - 1.1e-78 264.2 0.0 1.5e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KPI88219.1 - 4.5e-33 114.7 0.1 8.1e-33 113.8 0.0 1.5 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 KPI88219.1 - 0.011 15.3 0.0 0.37 10.2 0.1 2.8 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Aldo_ket_red PF00248.21 KPI88219.1 - 0.035 13.3 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 Aldo/keto reductase family Paf67 PF10255.9 KPI88220.1 - 5.2e-51 173.9 0.1 1.1e-50 172.8 0.1 1.5 1 1 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 KPI88220.1 - 0.035 14.2 0.1 0.33 11.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI88220.1 - 0.077 12.8 0.1 0.73 9.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat HEPPP_synt_1 PF07307.11 KPI88220.1 - 0.22 11.1 0.5 2.2 7.8 0.1 2.4 3 0 0 3 3 3 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 KASH_CCD PF14662.6 KPI88221.1 - 0.00013 21.9 20.5 0.00025 21.0 20.5 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Seryl_tRNA_N PF02403.22 KPI88221.1 - 0.011 15.9 10.7 0.011 15.9 10.7 2.2 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HAP1_N PF04849.13 KPI88221.1 - 0.018 14.3 15.3 0.01 15.1 13.4 1.5 2 0 0 2 2 2 0 HAP1 N-terminal conserved region ADIP PF11559.8 KPI88221.1 - 0.22 11.6 25.4 0.033 14.3 20.6 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 KPI88221.1 - 0.4 10.7 3.2 0.6 10.2 2.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4446 PF14584.6 KPI88221.1 - 0.92 9.5 4.5 0.27 11.2 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) ATG16 PF08614.11 KPI88221.1 - 1.6 8.9 30.1 14 5.9 30.1 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 KPI88221.1 - 2.6 8.2 22.0 0.12 12.5 1.8 2.9 3 1 0 3 3 3 0 bZIP transcription factor FapA PF03961.13 KPI88221.1 - 2.7 6.5 7.1 3.7 6.1 7.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Atg14 PF10186.9 KPI88221.1 - 3.2 6.7 21.3 0.62 9.1 15.4 2.4 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 PRKG1_interact PF15898.5 KPI88221.1 - 4.1 8.4 23.3 3.6 8.5 18.1 2.1 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 KPI88221.1 - 5.2 7.8 16.1 7.5 7.3 3.5 2.7 2 1 1 3 3 3 0 Initiation control protein YabA Fungal_TACC PF12709.7 KPI88221.1 - 7 7.2 10.7 10 6.6 3.4 3.0 1 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Spc7 PF08317.11 KPI88221.1 - 9 5.1 18.4 2.9 6.7 15.7 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein FKBP_C PF00254.28 KPI88222.1 - 2.8e-25 88.5 0.0 3.5e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Glycos_transf_2 PF00535.26 KPI88223.1 - 5.5e-31 107.7 0.0 7e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KPI88223.1 - 1.6e-07 31.4 0.0 2.3e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KPI88223.1 - 0.019 14.4 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 KPI88223.1 - 0.029 14.9 0.0 0.057 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 SET PF00856.28 KPI88224.1 - 8.1e-10 39.3 0.1 4.4e-08 33.7 0.1 2.5 1 1 0 1 1 1 1 SET domain DivIC PF04977.15 KPI88226.1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Septum formation initiator HECT PF00632.25 KPI88228.1 - 2.4e-44 152.1 0.0 4e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) C1_2 PF03107.16 KPI88228.1 - 0.048 14.0 14.6 0.16 12.3 14.6 1.9 1 0 0 1 1 1 0 C1 domain Adaptin_N PF01602.20 KPI88229.1 - 6.9e-77 259.2 4.6 9.6e-77 258.7 4.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 KPI88229.1 - 2.1e-05 24.8 0.0 4.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Vac14_Fab1_bd PF12755.7 KPI88229.1 - 0.018 15.6 3.0 7 7.3 0.1 3.9 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region Ribosomal_L7Ae PF01248.26 KPI88230.1 - 6.3e-19 67.5 0.5 7.7e-19 67.2 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Rgp1 PF08737.10 KPI88231.1 - 1.5e-05 24.4 0.5 0.056 12.6 0.0 2.4 1 1 0 2 2 2 2 Rgp1 Arrestin_N PF00339.29 KPI88231.1 - 0.018 15.1 0.0 0.049 13.7 0.0 1.7 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Peptidase_C78 PF07910.13 KPI88232.1 - 1.5e-48 165.1 0.0 2.1e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 KPI88232.1 - 0.064 12.7 0.0 0.42 10.0 0.0 2.0 2 0 0 2 2 2 0 Peptidase family C54 DUF445 PF04286.12 KPI88234.1 - 0.0026 17.7 0.1 0.0039 17.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Nif11 PF07862.11 KPI88234.1 - 0.096 13.0 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Nif11 domain Prenyltrans PF00432.21 KPI88235.1 - 8.1e-67 220.6 13.5 9.8e-13 47.6 0.2 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KPI88235.1 - 2.1e-08 33.6 0.0 0.083 12.0 0.0 4.3 1 1 3 4 4 4 4 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 KPI88235.1 - 7.2e-05 22.0 0.8 0.013 14.6 0.1 3.0 1 1 2 3 3 3 2 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 KPI88235.1 - 0.016 14.2 0.2 0.23 10.4 0.0 2.7 2 1 1 3 3 3 0 A-macroglobulin TED domain UCH PF00443.29 KPI88238.1 - 3.7e-34 118.4 0.1 5.4e-34 117.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI88238.1 - 1e-09 38.5 0.3 1.6e-08 34.5 0.3 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Casc1_N PF15927.5 KPI88239.1 - 4.8e-12 46.0 1.9 2.2e-11 43.9 1.9 2.0 1 1 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus SLT_L PF14718.6 KPI88239.1 - 0.002 18.2 4.3 0.0034 17.5 2.6 2.3 2 0 0 2 2 2 1 Soluble lytic murein transglycosylase L domain DnaJ PF00226.31 KPI88240.1 - 1.5e-07 31.4 0.5 4.9e-07 29.8 0.2 1.9 2 0 0 2 2 2 1 DnaJ domain GRIP PF01465.20 KPI88241.1 - 3.8e-11 42.7 1.5 6.1e-11 42.0 0.3 2.0 2 0 0 2 2 2 1 GRIP domain UPF0242 PF06785.11 KPI88241.1 - 0.00022 21.4 3.7 0.00022 21.4 3.7 3.5 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0242) N-terminus DUF1993 PF09351.10 KPI88241.1 - 0.04 14.0 2.5 0.06 13.5 0.7 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) Gp-FAR-1 PF05823.12 KPI88241.1 - 0.53 10.6 4.8 2.5 8.5 1.6 2.7 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fmp27_WPPW PF10359.9 KPI88241.1 - 0.76 8.6 8.9 0.11 11.3 3.7 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF2721 PF11026.8 KPI88241.1 - 1.5 8.7 3.3 49 3.8 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) FapA PF03961.13 KPI88241.1 - 2.9 6.4 6.0 3.4 6.2 2.5 2.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF1515 PF07439.11 KPI88241.1 - 3.1 7.9 11.6 3 7.9 3.2 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF1515) TSC22 PF01166.18 KPI88241.1 - 4.9 7.5 12.1 4.5 7.7 0.1 4.9 3 2 2 5 5 5 0 TSC-22/dip/bun family Atg14 PF10186.9 KPI88241.1 - 6.9 5.7 15.3 3.2 6.8 10.4 2.4 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 P35 PF02331.15 KPI88242.1 - 0.0016 17.8 0.3 0.0023 17.3 0.3 1.2 1 0 0 1 1 1 1 Apoptosis preventing protein vATP-synt_E PF01991.18 KPI88242.1 - 0.072 12.5 5.3 0.13 11.7 5.3 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit SAGA-Tad1 PF12767.7 KPI88242.1 - 0.12 12.1 1.3 0.18 11.5 1.3 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Rotamase PF00639.21 KPI88242.1 - 0.63 11.0 5.5 0.23 12.4 2.0 2.1 2 0 0 2 2 2 0 PPIC-type PPIASE domain HEAT_EZ PF13513.6 KPI88243.1 - 3.5 8.2 9.4 19 5.9 0.2 5.2 6 0 0 6 6 6 0 HEAT-like repeat Abhydrolase_6 PF12697.7 KPI88244.1 - 0.00064 20.4 2.0 0.00087 20.0 1.8 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KPI88244.1 - 0.0016 18.1 0.0 0.0036 17.0 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold EMC1_C PF07774.13 KPI88245.1 - 5.5e-45 153.7 0.0 3.3e-44 151.1 0.0 2.3 3 0 0 3 3 3 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 KPI88245.1 - 0.0017 18.0 5.4 0.013 15.1 2.7 3.4 3 1 1 4 4 4 1 PQQ-like domain PQQ_3 PF13570.6 KPI88245.1 - 0.043 14.3 1.2 13 6.4 0.1 3.8 2 1 0 2 2 2 0 PQQ-like domain Striatin PF08232.12 KPI88246.1 - 2.2 8.8 9.3 0.6 10.7 4.5 2.2 2 0 0 2 2 2 0 Striatin family REPA_OB_2 PF16900.5 KPI88247.1 - 2.9e-05 23.9 1.1 0.094 12.7 0.0 2.5 2 0 0 2 2 2 2 Replication protein A OB domain AAA_6 PF12774.7 KPI88248.1 - 4.7e-128 426.8 1.2 2.8e-127 424.2 0.0 3.0 4 0 0 4 4 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI88248.1 - 4.2e-109 365.3 6.7 4.2e-109 365.3 6.7 5.4 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KPI88248.1 - 5.7e-62 208.7 1.8 5.7e-62 208.7 1.8 3.7 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 KPI88248.1 - 1.2e-46 159.2 1.8 3.3e-43 147.9 0.0 4.8 5 0 0 5 5 4 1 P-loop containing dynein motor region D4 DHC_N1 PF08385.12 KPI88248.1 - 1.3e-38 133.0 0.0 1.3e-38 133.0 0.0 3.9 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 1 AAA_5 PF07728.14 KPI88248.1 - 1.1e-35 122.6 0.0 3.7e-21 75.6 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KPI88248.1 - 9.5e-34 116.5 0.0 1.2e-28 99.8 0.0 3.9 3 0 0 3 3 3 2 P-loop containing dynein motor region Dynein_heavy PF03028.15 KPI88248.1 - 8.7e-30 103.3 0.0 1.4e-28 99.4 0.0 3.2 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI88248.1 - 7.2e-29 100.9 12.6 2e-28 99.4 12.6 1.8 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KPI88248.1 - 3e-28 98.7 0.0 6.6e-28 97.6 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_C PF18199.1 KPI88248.1 - 1.1e-27 97.0 0.6 8.9e-27 94.1 0.0 2.8 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_16 PF13191.6 KPI88248.1 - 4.4e-15 56.5 0.4 7.8e-06 26.4 0.0 6.2 6 0 0 6 6 3 2 AAA ATPase domain AAA_22 PF13401.6 KPI88248.1 - 1.3e-11 44.9 0.3 0.0013 19.0 0.0 5.8 5 0 0 5 5 3 2 AAA domain AAA PF00004.29 KPI88248.1 - 1.3e-10 41.8 0.0 0.056 13.9 0.0 4.5 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KPI88248.1 - 1.1e-07 31.9 0.0 0.0011 18.9 0.0 3.1 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 KPI88248.1 - 1.3e-07 31.5 0.0 0.0014 18.4 0.0 3.6 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 KPI88248.1 - 1.5e-07 31.7 0.0 0.22 11.9 0.0 3.8 3 0 0 3 3 3 2 RNA helicase ABC_tran PF00005.27 KPI88248.1 - 3e-07 31.1 4.7 0.0046 17.5 0.0 4.9 5 0 0 5 5 2 2 ABC transporter AAA_24 PF13479.6 KPI88248.1 - 5.9e-06 26.2 0.0 0.12 12.1 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 KPI88248.1 - 8.1e-06 26.4 0.7 0.18 12.4 0.0 5.0 4 0 0 4 4 3 1 AAA domain AAA_28 PF13521.6 KPI88248.1 - 8.2e-06 26.1 0.0 1.8 8.8 0.0 4.5 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 KPI88248.1 - 1.5e-05 25.2 0.1 0.19 11.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 KPI88248.1 - 7.6e-05 22.5 0.0 0.11 12.2 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 KPI88248.1 - 0.00011 22.2 0.0 0.086 12.9 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 KPI88248.1 - 0.00033 20.3 0.0 0.046 13.5 0.0 2.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KPI88248.1 - 0.00079 19.2 0.0 0.083 12.6 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein cobW PF02492.19 KPI88248.1 - 0.00086 18.9 3.9 3.2 7.3 0.0 3.9 4 0 0 4 4 3 1 CobW/HypB/UreG, nucleotide-binding domain Guanylate_kin PF00625.21 KPI88248.1 - 0.00099 18.8 4.2 0.026 14.2 0.0 3.5 3 0 0 3 3 2 1 Guanylate kinase CbiA PF01656.23 KPI88248.1 - 0.001 19.1 0.0 6.7 6.8 0.0 4.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 KPI88248.1 - 0.0011 18.1 0.1 0.027 13.5 0.0 2.7 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 KPI88248.1 - 0.0015 18.6 0.4 1.7 8.8 0.1 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 KPI88248.1 - 0.0016 18.4 4.3 0.98 9.3 0.0 4.0 5 0 0 5 5 2 2 NACHT domain Rad17 PF03215.15 KPI88248.1 - 0.0022 18.0 0.4 3.2 7.6 0.0 3.9 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_25 PF13481.6 KPI88248.1 - 0.0023 17.5 0.0 4.7 6.7 0.0 3.5 2 0 0 2 2 2 0 AAA domain AAA_lid_7 PF17867.1 KPI88248.1 - 0.0036 17.5 0.0 0.036 14.2 0.0 2.8 2 0 0 2 2 1 1 Midasin AAA lid domain NB-ARC PF00931.22 KPI88248.1 - 0.0055 15.9 0.0 1.9 7.6 0.0 3.0 2 0 0 2 2 2 1 NB-ARC domain IIGP PF05049.13 KPI88248.1 - 0.006 15.7 1.4 0.018 14.1 0.0 2.5 3 0 0 3 3 2 1 Interferon-inducible GTPase (IIGP) DUF815 PF05673.13 KPI88248.1 - 0.0064 15.7 0.1 5.1 6.2 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF815) SRPRB PF09439.10 KPI88248.1 - 0.0072 15.8 1.9 0.4 10.1 0.0 3.5 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit AAA_21 PF13304.6 KPI88248.1 - 0.0096 15.8 0.0 0.042 13.6 0.0 2.1 2 0 0 2 2 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 KPI88248.1 - 0.01 16.0 0.5 3.7 7.8 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 KPI88248.1 - 0.013 14.9 0.0 5.8 6.2 0.0 3.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 KPI88248.1 - 0.018 15.1 0.3 2.2 8.3 0.0 4.0 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Nucleo_P87 PF07267.11 KPI88248.1 - 0.02 13.8 0.8 0.052 12.4 0.8 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AAA_PrkA PF08298.11 KPI88248.1 - 0.025 13.5 0.0 0.25 10.2 0.0 2.3 2 0 0 2 2 2 0 PrkA AAA domain Adeno_IVa2 PF02456.15 KPI88248.1 - 0.03 13.1 0.0 5.2 5.8 0.0 2.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein ATPase_2 PF01637.18 KPI88248.1 - 0.038 13.9 12.8 0.32 10.9 0.0 4.6 5 0 0 5 5 3 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 KPI88248.1 - 0.041 13.7 4.5 2.2 8.0 0.0 4.4 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.18 KPI88248.1 - 0.049 13.4 0.1 0.56 9.9 0.1 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 KPI88248.1 - 0.07 12.4 0.0 2.2 7.5 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin MeaB PF03308.16 KPI88248.1 - 0.08 11.9 0.0 0.29 10.1 0.0 1.9 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DXP_reductoisom PF02670.16 KPI88248.1 - 0.11 13.3 0.0 0.73 10.6 0.0 2.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Ploopntkinase3 PF18751.1 KPI88248.1 - 0.11 12.4 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_23 PF13476.6 KPI88248.1 - 1.8 9.1 0.0 1.8 9.1 0.0 7.8 8 1 0 8 8 6 0 AAA domain zf-CCHC_3 PF13917.6 KPI88249.1 - 5.9e-11 42.1 1.7 1.1e-10 41.2 1.7 1.5 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 KPI88249.1 - 0.0085 16.5 0.8 0.0085 16.5 0.8 2.3 2 1 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G TRAUB PF08164.12 KPI88249.1 - 0.067 13.7 0.1 0.13 12.8 0.1 1.6 1 0 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal Fam20C PF06702.12 KPI88250.1 - 1.3e-06 28.5 0.0 0.0025 17.7 0.0 2.3 2 0 0 2 2 2 2 Golgi casein kinase, C-terminal, Fam20 Metallophos PF00149.28 KPI88251.1 - 8.1e-34 117.9 0.0 1.1e-33 117.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Amastin PF07344.11 KPI88251.1 - 0.12 12.2 0.1 0.59 10.0 0.0 1.9 2 0 0 2 2 2 0 Amastin surface glycoprotein CssAB PF16831.5 KPI88252.1 - 0.28 11.6 1.2 0.41 11.0 0.2 1.7 2 0 0 2 2 2 0 CS6 fimbrial subunits A and B, Coli surface antigen 6 DnaB_bind PF10410.9 KPI88253.1 - 0.17 12.1 0.1 0.27 11.4 0.1 1.3 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase TetR_C_25 PF17933.1 KPI88253.1 - 0.18 12.1 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain FHA PF00498.26 KPI88255.1 - 4.8e-07 30.0 0.0 1.1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 FHA domain BRCT PF00533.26 KPI88255.1 - 2.7e-06 27.7 0.0 0.0016 18.8 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KPI88255.1 - 0.0058 16.6 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 1 twin BRCT domain BRCT_2 PF16589.5 KPI88255.1 - 0.021 15.2 0.0 4.1 7.9 0.0 2.6 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 KPI88255.1 - 0.031 14.1 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain SWIRM-assoc_2 PF16496.5 KPI88255.1 - 0.25 10.2 3.8 0.45 9.3 3.8 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Kinesin PF00225.23 KPI88257.1 - 2.2e-106 355.6 0.3 3.2e-106 355.0 0.3 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI88257.1 - 3.6e-18 65.9 0.0 8.3e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Pex24p PF06398.11 KPI88257.1 - 5.3e-07 29.0 2.6 1e-06 28.0 2.6 1.4 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Kinesin_assoc PF16183.5 KPI88257.1 - 0.12 12.5 11.9 0.41 10.8 0.3 2.7 1 1 1 2 2 2 0 Kinesin-associated AAA_13 PF13166.6 KPI88257.1 - 0.12 11.0 8.6 0.22 10.1 8.6 1.3 1 0 0 1 1 1 0 AAA domain CREPT PF16566.5 KPI88257.1 - 0.42 10.8 13.9 0.94 9.6 13.9 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour COG5 PF10392.9 KPI88257.1 - 0.44 10.7 8.5 1.2 9.3 8.5 1.7 1 0 0 1 1 1 0 Golgi transport complex subunit 5 FAM76 PF16046.5 KPI88257.1 - 0.58 9.5 7.6 1.1 8.5 7.6 1.5 1 0 0 1 1 1 0 FAM76 protein HAUS6_N PF14661.6 KPI88257.1 - 1.4 8.5 8.9 0.83 9.2 6.6 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus UPF0242 PF06785.11 KPI88257.1 - 2.5 8.2 20.1 0.16 12.1 14.5 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 KPI88257.1 - 4.2 7.5 9.7 14 5.9 9.5 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 KPI88257.1 - 9.5 5.0 23.2 16 4.2 23.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Cullin_binding PF03556.15 KPI88258.1 - 1.1e-14 54.8 0.3 2.1e-14 54.0 0.3 1.4 1 0 0 1 1 1 1 Cullin binding Ank_2 PF12796.7 KPI88259.1 - 3.7e-27 94.7 8.5 4.2e-12 46.5 0.4 4.0 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI88259.1 - 1.1e-18 67.3 1.3 6.1e-07 29.9 0.1 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI88259.1 - 1e-16 59.3 1.5 0.00039 20.6 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 KPI88259.1 - 6.5e-15 55.0 2.4 1e-06 28.9 0.0 5.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KPI88259.1 - 1.2e-10 41.3 0.2 0.0054 17.1 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Gar1 PF04410.14 KPI88260.1 - 3.8e-27 95.0 0.0 4.5e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DHHC PF01529.20 KPI88261.1 - 5.6e-13 49.2 8.7 5.6e-13 49.2 8.7 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase Pkinase PF00069.25 KPI88263.1 - 1.2e-43 149.4 0.0 1.8e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88263.1 - 5.1e-25 88.2 0.0 9e-25 87.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI88263.1 - 0.00014 20.8 0.0 0.00027 19.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase PH PF00169.29 KPI88263.1 - 0.0004 20.8 0.0 0.00082 19.9 0.0 1.6 1 0 0 1 1 1 1 PH domain Haspin_kinase PF12330.8 KPI88263.1 - 0.031 13.2 0.2 0.068 12.1 0.2 1.5 1 1 0 1 1 1 0 Haspin like kinase domain TEBP_beta PF07404.11 KPI88263.1 - 0.12 11.8 1.3 0.19 11.1 1.3 1.2 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) Seadorna_VP7 PF07387.11 KPI88263.1 - 0.15 11.1 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 PH_9 PF15410.6 KPI88263.1 - 0.15 12.4 0.1 0.67 10.3 0.1 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain ELMO_CED12 PF04727.13 KPI88264.1 - 8.7e-26 91.1 0.0 1.7e-25 90.2 0.0 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family zf-B_box PF00643.24 KPI88265.1 - 5.4e-09 36.1 20.5 1e-07 31.9 7.4 3.7 5 0 0 5 5 5 2 B-box zinc finger LRR_8 PF13855.6 KPI88266.1 - 1.8e-20 72.5 20.3 5.1e-08 32.6 0.2 4.8 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KPI88266.1 - 1.1e-17 63.8 15.9 5.1e-05 23.5 0.6 5.8 3 2 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI88266.1 - 4e-06 26.5 6.6 0.016 14.7 0.5 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 KPI88266.1 - 0.0013 18.6 14.7 6.7 7.0 0.1 6.7 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 KPI88266.1 - 0.12 13.0 17.2 66 4.7 0.1 7.2 7 2 0 7 7 7 0 Leucine Rich Repeat LRR_5 PF13306.6 KPI88266.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) RhlB PF12300.8 KPI88266.1 - 0.18 11.9 7.3 0.38 10.9 7.3 1.5 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB DUF4407 PF14362.6 KPI88267.1 - 2.3e-05 23.9 23.1 0.0065 15.9 18.1 2.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4407) STAG PF08514.11 KPI88269.1 - 1.7e-20 73.0 0.8 7.3e-20 71.0 0.1 2.5 2 0 0 2 2 2 1 STAG domain Proteasome PF00227.26 KPI88271.1 - 4.9e-58 195.7 0.0 6.1e-58 195.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI88271.1 - 2.2e-13 49.6 0.0 6.5e-13 48.1 0.0 1.9 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature zf-CCHC PF00098.23 KPI88272.1 - 1.1e-44 148.6 39.2 4.2e-10 39.2 1.8 5.1 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_3 PF13917.6 KPI88272.1 - 3e-15 55.9 29.0 0.0018 18.2 0.9 5.0 1 1 4 5 5 5 5 Zinc knuckle zf-CCHC_4 PF14392.6 KPI88272.1 - 1.5e-10 40.7 26.2 0.056 13.2 0.8 5.0 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_2 PF13696.6 KPI88272.1 - 1.6e-08 34.2 30.1 0.0074 16.1 0.9 5.3 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_6 PF15288.6 KPI88272.1 - 2.3e-05 24.2 25.5 0.28 11.1 0.5 5.3 1 1 4 5 5 5 4 Zinc knuckle zf-CCHC_5 PF14787.6 KPI88272.1 - 0.00086 19.0 30.7 0.9 9.3 1.0 5.1 5 0 0 5 5 5 5 GAG-polyprotein viral zinc-finger TRAF6_Z2 PF18048.1 KPI88272.1 - 0.0026 17.8 8.8 28 4.9 0.1 5.4 5 0 0 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 HscB_4_cys PF18256.1 KPI88272.1 - 0.032 14.0 23.9 5.1 7.0 0.5 5.4 5 0 0 5 5 5 0 Co-chaperone HscB tetracysteine metal binding motif DZR PF12773.7 KPI88272.1 - 0.15 12.1 32.1 1.8e+04 -7.6 31.9 3.6 1 1 0 1 1 1 0 Double zinc ribbon zf-CCHC PF00098.23 KPI88273.1 - 8.8e-45 148.9 39.9 5.9e-10 38.8 2.3 5.1 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_3 PF13917.6 KPI88273.1 - 2.9e-16 59.2 29.0 0.00061 19.7 0.9 5.0 1 1 4 5 5 5 5 Zinc knuckle zf-CCHC_4 PF14392.6 KPI88273.1 - 2e-09 37.1 25.7 0.069 12.9 0.9 5.0 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_2 PF13696.6 KPI88273.1 - 1.8e-08 34.0 30.4 0.0084 15.9 1.3 5.2 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_6 PF15288.6 KPI88273.1 - 2.2e-06 27.4 25.5 0.27 11.1 1.6 5.3 2 2 3 5 5 5 4 Zinc knuckle zf-CCHC_5 PF14787.6 KPI88273.1 - 0.0029 17.3 28.8 2.4 7.9 0.3 5.1 5 0 0 5 5 5 5 GAG-polyprotein viral zinc-finger TRAF6_Z2 PF18048.1 KPI88273.1 - 0.0054 16.8 12.8 13 6.0 0.3 5.6 5 1 0 5 5 5 1 TNF receptor-associated factor 6 zinc finger 2 HscB_4_cys PF18256.1 KPI88273.1 - 0.059 13.2 24.2 7.9 6.4 0.6 5.4 5 0 0 5 5 5 0 Co-chaperone HscB tetracysteine metal binding motif DZR PF12773.7 KPI88273.1 - 0.12 12.4 32.8 5.2 7.2 11.0 3.6 1 1 1 2 2 2 0 Double zinc ribbon NinD PF17466.2 KPI88273.1 - 1.4 9.1 24.8 9.1 6.4 0.2 4.9 4 1 1 5 5 5 0 Family of unknown function NMD3 PF04981.13 KPI88273.1 - 7.8 5.9 19.0 5.7 6.3 8.7 2.0 1 1 1 2 2 2 0 NMD3 family Clathrin PF00637.20 KPI88274.1 - 1e-165 544.2 43.6 1.6e-28 99.4 0.5 8.3 9 0 0 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 KPI88274.1 - 1.5e-19 69.6 0.4 7.5e-19 67.4 0.0 2.5 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 KPI88274.1 - 5.5e-09 35.9 0.5 0.063 13.6 0.0 5.5 5 0 0 5 5 5 2 Clathrin propeller repeat Clathrin-link PF09268.10 KPI88274.1 - 1.1e-08 34.2 0.3 3.4e-08 32.7 0.3 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_14 PF13428.6 KPI88274.1 - 1.4e-05 25.5 0.1 67 4.7 0.0 7.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI88274.1 - 7e-05 22.5 2.7 1.2 9.1 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat Mic1 PF07035.12 KPI88274.1 - 0.0018 18.0 6.2 0.049 13.4 0.0 4.4 3 1 1 4 4 4 1 Colon cancer-associated protein Mic1-like TPR_7 PF13176.6 KPI88274.1 - 0.0081 16.1 5.9 25 5.2 0.1 6.6 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI88274.1 - 0.07 13.3 11.0 14 6.1 0.1 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI88274.1 - 0.12 12.7 8.1 56 4.3 0.0 6.8 8 0 0 8 8 8 0 Tetratricopeptide repeat PDDEXK_10 PF07788.11 KPI88274.1 - 0.42 10.6 4.6 4.9 7.2 0.0 3.6 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily zf-CCHC PF00098.23 KPI88275.1 - 1.8e-36 122.6 54.0 6e-08 32.4 1.5 6.1 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_3 PF13917.6 KPI88275.1 - 9.6e-09 35.1 32.5 0.014 15.4 1.2 4.8 3 2 1 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 KPI88275.1 - 2.2e-06 27.4 53.0 0.015 15.1 4.4 6.4 6 0 0 6 6 6 5 Zinc knuckle zf-CCHC_4 PF14392.6 KPI88275.1 - 4e-06 26.5 33.2 0.12 12.2 1.4 6.0 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_5 PF14787.6 KPI88275.1 - 0.0032 17.1 39.2 0.012 15.4 0.8 5.5 4 2 1 5 5 5 4 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 KPI88276.1 - 5.7e-74 241.1 88.1 6e-09 35.6 3.2 9.2 9 0 0 9 9 9 9 Zinc knuckle zf-CCHC_3 PF13917.6 KPI88276.1 - 3.6e-27 94.0 55.9 0.002 18.1 1.4 9.1 4 2 5 9 9 9 9 Zinc knuckle zf-CCHC_2 PF13696.6 KPI88276.1 - 8.3e-08 31.9 65.4 0.0008 19.2 0.9 9.4 9 0 0 9 9 9 5 Zinc knuckle zf-CCHC_4 PF14392.6 KPI88276.1 - 6.9e-07 28.9 56.7 1.3 8.9 0.5 9.1 9 0 0 9 9 9 8 Zinc knuckle zf-CCHC_5 PF14787.6 KPI88276.1 - 6.5e-06 25.8 62.3 0.21 11.3 1.2 9.1 8 1 1 9 9 9 8 GAG-polyprotein viral zinc-finger TRAF6_Z2 PF18048.1 KPI88276.1 - 0.00038 20.5 26.7 12 6.0 0.1 8.8 9 0 0 9 9 9 1 TNF receptor-associated factor 6 zinc finger 2 zf-CCHC_6 PF15288.6 KPI88276.1 - 0.039 13.8 73.8 0.14 12.0 2.1 9.1 9 0 0 9 9 9 0 Zinc knuckle Ntox16 PF15523.6 KPI88276.1 - 0.053 13.8 47.5 2.2 8.6 0.6 8.7 6 2 3 9 9 9 0 Novel toxin 16 NinD PF17466.2 KPI88276.1 - 8.7 6.5 50.5 5 7.3 0.4 8.4 9 0 0 9 9 9 0 Family of unknown function Proteasome PF00227.26 KPI88277.1 - 3.3e-49 167.0 0.4 4e-49 166.7 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit S4 PF01479.25 KPI88278.1 - 3.9e-07 29.7 0.0 3.7e-06 26.6 0.1 2.4 2 0 0 2 2 2 1 S4 domain PseudoU_synth_2 PF00849.22 KPI88278.1 - 2.3e-05 24.6 0.0 3.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Q_salvage PF10343.9 KPI88279.1 - 1.2e-14 54.6 0.0 1.9e-13 50.7 0.0 2.1 2 0 0 2 2 2 1 Potential Queuosine, Q, salvage protein family Ank PF00023.30 KPI88279.1 - 0.16 12.5 0.1 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat IQ PF00612.27 KPI88280.1 - 0.073 12.9 9.7 1.4 8.9 1.1 3.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif Peptidase_M76 PF09768.9 KPI88281.1 - 2.8e-52 177.0 0.0 6.7e-52 175.7 0.0 1.6 1 1 0 1 1 1 1 Peptidase M76 family PCYCGC PF13798.6 KPI88281.1 - 0.061 13.2 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif GPI2 PF06432.11 KPI88283.1 - 2.2e-67 227.4 8.2 2.6e-67 227.2 8.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Sensor PF13796.6 KPI88283.1 - 0.0039 17.2 0.7 0.0039 17.2 0.7 2.2 1 1 1 2 2 2 1 Putative sensor DUF423 PF04241.15 KPI88283.1 - 3.9 7.7 8.6 0.22 11.8 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF423) Beach PF02138.18 KPI88284.1 - 3.1e-106 354.8 0.0 4.6e-106 354.2 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KPI88284.1 - 1.1e-16 60.8 0.0 2e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 KPI88284.1 - 0.007 16.5 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sec34 PF04136.15 KPI88285.1 - 4e-11 43.0 2.5 4e-11 43.0 2.5 1.8 2 0 0 2 2 2 1 Sec34-like family Sec7_N PF12783.7 KPI88286.1 - 0.15 12.0 0.4 0.51 10.2 0.4 1.9 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TM231 PF10149.9 KPI88287.1 - 0.15 11.4 0.1 0.24 10.7 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 231 AAA PF00004.29 KPI88290.1 - 2.8e-11 44.0 0.2 1.9e-10 41.3 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI88290.1 - 1.1e-08 35.5 0.1 4e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KPI88290.1 - 2.8e-07 31.1 0.0 4.4e-06 27.2 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 KPI88290.1 - 9.8e-05 22.7 0.1 0.00034 21.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KPI88290.1 - 0.00015 21.2 0.0 0.00022 20.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 KPI88290.1 - 0.00036 20.5 0.1 0.0054 16.7 0.0 2.4 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 KPI88290.1 - 0.0023 17.1 0.0 0.0044 16.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.12 KPI88290.1 - 0.0062 16.5 0.1 0.017 15.1 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 KPI88290.1 - 0.0082 15.9 0.0 0.021 14.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KPI88290.1 - 0.0083 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KPI88290.1 - 0.01 15.9 0.1 0.031 14.3 0.1 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit NB-ARC PF00931.22 KPI88290.1 - 0.02 14.1 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 KPI88290.1 - 0.028 14.4 0.0 0.84 9.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KPI88290.1 - 0.035 13.6 0.1 0.11 11.9 0.1 1.9 1 1 1 2 2 2 0 P-loop containing dynein motor region UvrD-helicase PF00580.21 KPI88290.1 - 0.13 11.8 0.1 0.23 11.0 0.1 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain PPR_2 PF13041.6 KPI88291.1 - 1.5e-05 25.0 0.0 0.086 13.0 0.0 4.0 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 KPI88291.1 - 3.6e-05 23.7 0.9 6.4 7.3 0.0 6.5 9 0 0 9 9 9 2 PPR repeat TPR_16 PF13432.6 KPI88291.1 - 2 9.1 5.1 5.7 7.7 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat NYD-SP28 PF14772.6 KPI88292.1 - 1.2e-16 60.5 9.2 1.2e-16 60.5 9.2 5.1 3 1 1 5 5 5 1 Sperm tail NYD-SP28_assoc PF14775.6 KPI88292.1 - 8.6e-06 25.8 0.3 6.3e-05 23.0 0.3 2.6 1 0 0 1 1 1 1 Sperm tail C-terminal domain DUF5521 PF17659.1 KPI88292.1 - 0.0033 15.4 0.0 0.0033 15.4 0.0 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5521) BAG6 PF12057.8 KPI88292.1 - 0.011 15.4 3.9 0.029 14.0 0.2 2.8 3 0 0 3 3 3 0 BCL2-associated athanogene 6 RNA_pol_N PF01194.17 KPI88292.1 - 0.16 12.3 0.1 1.2 9.5 0.1 2.6 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit DUF5069 PF16798.5 KPI88292.1 - 0.58 10.4 11.3 0.066 13.4 4.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5069) PRESAN PF09687.10 KPI88292.1 - 1.5 9.3 9.9 0.96 10.0 6.9 2.2 2 0 0 2 2 2 0 Plasmodium RESA N-terminal DUF5593 PF18007.1 KPI88292.1 - 3 8.6 4.9 1.4 9.7 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5593) FUSC PF04632.12 KPI88292.1 - 5.4 5.4 32.4 0.014 14.0 16.0 2.5 1 1 0 2 2 2 0 Fusaric acid resistance protein family NFRKB_winged PF14465.6 KPI88292.1 - 8.9 6.6 7.4 35 4.6 0.6 3.2 2 1 1 3 3 3 0 NFRKB Winged Helix-like FIST PF08495.10 KPI88293.1 - 0.0038 17.3 0.1 0.008 16.2 0.1 1.6 1 0 0 1 1 1 1 FIST N domain Ank_5 PF13857.6 KPI88295.1 - 1.4e-07 31.6 0.1 1.2e-05 25.5 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI88295.1 - 6.9e-07 29.8 4.0 2.1e-06 28.2 0.1 3.3 3 1 1 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI88295.1 - 2.1e-05 24.9 0.4 0.00049 20.6 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI88295.1 - 0.0009 19.5 0.1 4.2 8.3 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KPI88295.1 - 0.078 13.5 5.4 5 7.8 0.0 4.3 4 0 0 4 4 4 0 Ankyrin repeat IQ PF00612.27 KPI88295.1 - 0.16 11.8 0.0 0.16 11.8 0.0 5.7 5 0 0 5 5 5 0 IQ calmodulin-binding motif Guanylate_cyc PF00211.20 KPI88296.1 - 1.1e-24 87.1 0.0 2.4e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Globin PF00042.22 KPI88296.1 - 1.2e-09 38.7 0.0 0.00059 20.4 0.0 2.8 2 0 0 2 2 2 2 Globin DUF2852 PF11014.8 KPI88296.1 - 0.014 15.5 0.9 0.032 14.4 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Proteasome PF00227.26 KPI88298.1 - 1.2e-37 129.2 0.0 1.4e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit RNA_POL_M_15KD PF02150.16 KPI88299.1 - 0.00021 21.1 5.4 0.00021 21.1 5.4 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 KPI88299.1 - 0.047 13.5 4.7 0.047 13.5 4.7 3.2 3 1 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-Sec23_Sec24 PF04810.15 KPI88299.1 - 0.06 13.4 2.5 0.06 13.4 2.5 2.4 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger HNH_5 PF14279.6 KPI88299.1 - 0.69 9.8 6.4 4.9 7.1 0.0 3.1 2 1 0 2 2 2 0 HNH endonuclease zf-ribbon_3 PF13248.6 KPI88299.1 - 5.3 6.6 9.4 15 5.2 0.3 3.6 3 0 0 3 3 3 0 zinc-ribbon domain CM2 PF03021.14 KPI88300.1 - 0.34 10.7 1.9 2.6 7.9 0.1 2.2 1 1 1 2 2 2 0 Influenza C virus M2 protein Phage_holin_3_6 PF07332.11 KPI88300.1 - 0.61 10.1 6.5 0.19 11.8 0.3 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF5392 PF17370.2 KPI88300.1 - 3.6 7.7 6.2 2 8.5 0.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5392) Fumble PF03630.14 KPI88301.1 - 1.4e-93 313.7 0.0 2e-93 313.2 0.0 1.2 1 0 0 1 1 1 1 Fumble AMP-binding PF00501.28 KPI88301.1 - 8.2e-15 54.3 0.1 2e-14 53.1 0.1 1.5 1 1 0 1 1 1 1 AMP-binding enzyme Exo_endo_phos PF03372.23 KPI88301.1 - 2.2e-07 30.7 0.1 4.4e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 KPI88302.1 - 3.4e-30 105.2 33.3 6.1e-29 101.0 33.8 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KPI88302.1 - 0.00021 20.3 28.4 0.04 12.8 28.6 3.3 1 1 0 1 1 1 1 Sugar (and other) transporter ABC_tran_CTD PF16326.5 KPI88303.1 - 0.01 16.1 0.3 0.018 15.3 0.3 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain DSPc PF00782.20 KPI88304.1 - 3.5e-27 94.8 0.0 5.7e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 KPI88304.1 - 9.3e-09 34.9 0.8 3e-05 23.7 0.3 3.5 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 KPI88304.1 - 7.2e-08 32.6 2.3 0.00091 19.6 2.5 3.6 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI88304.1 - 8.4e-05 22.1 1.3 0.004 16.7 0.0 2.4 1 1 0 2 2 2 1 Leucine-rich repeat Y_phosphatase PF00102.27 KPI88304.1 - 0.0029 17.2 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KPI88304.1 - 0.032 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) DUF3945 PF13101.6 KPI88304.1 - 0.088 12.5 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) Init_tRNA_PT PF04179.12 KPI88304.1 - 0.16 12.3 0.0 0.51 10.6 0.0 1.9 2 0 0 2 2 2 0 Rit1 DUSP-like domain DUF2618 PF10940.8 KPI88306.1 - 0.14 12.0 3.2 0.43 10.4 3.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) Histone PF00125.24 KPI88308.1 - 7.7e-11 42.5 0.0 1e-10 42.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KPI88308.1 - 0.013 15.8 0.3 0.023 15.0 0.3 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DHHC PF01529.20 KPI88309.1 - 5.1e-24 84.9 6.1 3.9e-23 82.0 5.7 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase TMEM220 PF15071.6 KPI88309.1 - 0.29 11.9 6.8 0.78 10.5 1.7 2.8 3 0 0 3 3 3 0 Transmembrane family 220, helix DHHC PF01529.20 KPI88310.1 - 5.1e-32 110.8 3.6 5.1e-32 110.8 3.6 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Baculo_11_kDa PF06143.11 KPI88310.1 - 0.16 11.5 0.3 0.34 10.5 0.3 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Calici_coat_C PF08435.11 KPI88311.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal DAO PF01266.24 KPI88312.1 - 1.6e-42 146.3 0.0 1.6e-42 146.3 0.0 1.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase DAO_C PF16901.5 KPI88312.1 - 2.2e-28 98.7 0.0 6.1e-28 97.2 0.0 1.8 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 KPI88312.1 - 0.0022 17.2 0.7 0.055 12.6 0.4 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 KPI88312.1 - 0.0057 16.1 1.4 0.0096 15.3 1.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KPI88312.1 - 0.016 14.5 0.3 0.07 12.3 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KPI88312.1 - 0.039 13.8 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KPI88312.1 - 0.06 12.6 0.0 0.33 10.2 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 KPI88312.1 - 0.14 11.2 1.7 0.63 9.1 0.3 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NADH-u_ox-rdase PF10785.9 KPI88313.1 - 3.1e-07 31.0 0.1 6.6e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit PAPS_reduct PF01507.19 KPI88315.1 - 1.5e-26 93.5 0.1 4.1e-24 85.6 0.1 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family HutD PF05962.11 KPI88317.1 - 0.021 14.8 0.0 0.049 13.6 0.0 1.6 2 0 0 2 2 2 0 HutD RNA_pol_Rpb1_2 PF00623.20 KPI88317.1 - 0.036 14.3 0.0 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 2 zf-HIT PF04438.16 KPI88318.1 - 3.5e-06 26.8 12.7 8.5e-06 25.5 12.7 1.6 1 0 0 1 1 1 1 HIT zinc finger zf-CCCH PF00642.24 KPI88318.1 - 3.9e-06 26.6 9.4 0.00011 22.0 0.3 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 KPI88318.1 - 0.0034 17.6 4.2 0.66 10.2 5.0 2.6 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 KPI88318.1 - 0.0037 17.7 6.6 0.6 10.7 0.4 2.8 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 KPI88318.1 - 0.035 14.2 1.5 0.035 14.2 1.5 2.7 2 0 0 2 2 2 0 Zinc finger domain Torus PF16131.5 KPI88318.1 - 0.04 14.6 0.5 0.04 14.6 0.5 2.8 2 1 1 3 3 3 0 Torus domain zf-CCCH_4 PF18044.1 KPI88318.1 - 0.1 12.5 8.9 0.086 12.7 1.0 2.8 2 0 0 2 2 2 0 CCCH-type zinc finger DUF5472 PF17566.2 KPI88319.1 - 0.11 12.5 0.8 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5472) GATA PF00320.27 KPI88320.1 - 6 6.6 6.8 1.3 8.7 0.1 2.7 3 0 0 3 3 3 0 GATA zinc finger RNB PF00773.19 KPI88321.1 - 4.6e-96 322.0 0.0 8.1e-96 321.2 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 KPI88321.1 - 6.3e-20 71.0 0.0 1.3e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 KPI88321.1 - 2e-08 34.1 0.0 3e-07 30.2 0.0 2.4 2 0 0 2 2 2 1 Rrp44-like cold shock domain PIN_4 PF13638.6 KPI88321.1 - 4.1e-07 30.4 0.1 9.8e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 KPI88321.1 - 5.8e-06 26.4 0.0 0.00014 22.0 0.0 2.5 2 0 0 2 2 2 1 Cold shock domain Rrp44_S1 PF17215.3 KPI88321.1 - 0.017 15.0 0.0 0.043 13.8 0.0 1.7 1 0 0 1 1 1 0 S1 domain Dis3l2_C_term PF17877.1 KPI88321.1 - 0.08 13.3 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal MtN3_slv PF03083.16 KPI88323.1 - 1.9e-17 63.0 14.9 1.8e-11 43.9 1.5 2.5 3 0 0 3 3 3 2 Sugar efflux transporter for intercellular exchange Gaa1 PF04114.14 KPI88323.1 - 0.002 17.2 4.1 0.0028 16.8 4.1 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component Complex1_LYR PF05347.15 KPI88324.1 - 5.3e-07 29.6 0.1 1.3e-06 28.3 0.1 1.7 1 1 0 1 1 1 1 Complex 1 protein (LYR family) AAA_6 PF12774.7 KPI88325.1 - 7.9e-145 481.9 1.5 2.6e-143 476.9 0.0 3.0 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 KPI88325.1 - 1.7e-141 472.7 12.9 1.7e-141 472.7 12.9 3.3 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 KPI88325.1 - 2.3e-114 382.6 5.3 2.3e-114 382.6 5.3 3.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 KPI88325.1 - 3.8e-87 291.9 0.0 1.1e-86 290.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KPI88325.1 - 3.6e-79 266.2 0.8 2.4e-77 260.2 0.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 KPI88325.1 - 9e-76 253.8 6.6 1.9e-75 252.8 5.6 2.2 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI88325.1 - 1.6e-53 180.9 5.3 3.9e-50 169.9 0.1 4.7 5 0 0 5 5 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI88325.1 - 5.8e-46 156.3 0.1 3.2e-44 150.6 0.1 3.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain MT PF12777.7 KPI88325.1 - 8.2e-40 136.9 8.4 8.2e-40 136.9 8.4 1.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KPI88325.1 - 6e-38 129.6 1.2 4.6e-36 123.5 0.1 3.6 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KPI88325.1 - 2.9e-20 72.7 0.2 2.1e-19 69.9 0.1 2.7 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KPI88325.1 - 6.7e-16 58.5 0.1 0.0012 18.9 0.0 6.3 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KPI88325.1 - 2.2e-11 43.8 0.1 4.3e-10 39.7 0.1 3.1 1 1 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 KPI88325.1 - 9.2e-08 32.6 0.3 0.038 14.4 0.0 5.7 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI88325.1 - 1.6e-05 25.3 0.1 5.8 7.3 0.0 5.5 5 0 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 KPI88325.1 - 0.0016 18.7 3.4 24 5.2 0.0 5.6 5 0 0 5 5 5 0 AAA domain AAA_18 PF13238.6 KPI88325.1 - 0.0088 16.6 0.0 0.24 12.0 0.0 3.4 2 0 0 2 2 2 1 AAA domain EF-hand_7 PF13499.6 KPI88326.1 - 0.016 15.6 0.0 0.4 11.2 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain pair DUF4485 PF14846.6 KPI88326.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) Tubulin PF00091.25 KPI88327.1 - 1.4e-67 227.7 0.0 2.1e-67 227.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KPI88327.1 - 4.2e-44 149.7 0.2 8.4e-44 148.8 0.2 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KPI88327.1 - 1e-05 25.8 0.0 3.3e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 KPI88327.1 - 0.0024 17.1 0.0 0.0039 16.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 KPI88327.1 - 0.042 13.5 0.0 0.1 12.2 0.0 1.6 2 0 0 2 2 2 0 Tubulin domain PUB PF09409.10 KPI88328.1 - 0.00063 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 PUB domain MIase PF02426.16 KPI88329.1 - 0.031 14.4 0.0 0.26 11.5 0.0 2.2 2 0 0 2 2 2 0 Muconolactone delta-isomerase Ank_4 PF13637.6 KPI88330.1 - 3.8e-19 68.8 0.1 8.3e-08 32.6 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI88330.1 - 3.7e-16 59.5 0.0 2.9e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI88330.1 - 7.1e-15 53.6 0.0 3.2e-06 27.0 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 KPI88330.1 - 8e-15 54.7 0.2 2.7e-08 33.9 0.0 4.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KPI88330.1 - 1.2e-14 54.0 0.0 1e-06 28.9 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat SLBP_RNA_bind PF15247.6 KPI88331.1 - 1.6e-16 60.2 1.1 3.2e-16 59.2 0.1 2.2 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain Pro_isomerase PF00160.21 KPI88332.1 - 2.3e-45 154.7 0.0 2.6e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF2085 PF09858.9 KPI88333.1 - 0.11 13.0 1.9 0.69 10.4 0.2 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2085) Ribosomal_L23 PF00276.20 KPI88334.1 - 1.5e-06 28.5 0.2 2.2e-06 27.9 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 LRR_8 PF13855.6 KPI88335.1 - 6.7e-17 61.0 8.2 4.4e-15 55.2 2.9 3.4 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 KPI88335.1 - 1.9e-09 37.6 4.4 0.00018 21.8 1.1 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI88335.1 - 0.0073 16.7 6.5 0.087 13.4 0.3 3.9 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.6 KPI88335.1 - 0.024 14.1 0.0 0.33 10.4 0.0 2.3 1 1 2 3 3 3 0 Leucine-rich repeat Clathrin_H_link PF13838.6 KPI88335.1 - 0.86 9.6 4.1 2.7 8.0 0.2 3.0 2 0 0 2 2 2 0 Clathrin-H-link Kdo PF06293.14 KPI88336.1 - 0.00028 20.3 0.1 0.0018 17.7 0.1 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI88336.1 - 0.018 14.6 0.1 0.23 11.0 0.1 2.1 1 1 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.17 KPI88336.1 - 0.11 11.8 0.0 0.28 10.4 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase PF00069.25 KPI88336.1 - 0.19 11.0 0.0 0.39 10.0 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain Na_H_Exchanger PF00999.21 KPI88337.1 - 3.1e-12 46.0 32.6 8.2e-12 44.6 32.6 1.7 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family zf-C2H2_assoc3 PF16637.5 KPI88338.1 - 1.9 8.8 10.8 4.6 7.5 4.0 3.0 2 0 0 2 2 2 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz ALF PF03752.13 KPI88339.1 - 0.076 13.0 4.7 0.31 11.0 4.7 2.2 1 0 0 1 1 1 0 Short repeats of unknown function Lectin_N PF03954.14 KPI88339.1 - 0.24 11.2 5.5 0.77 9.5 5.5 1.9 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain PH PF00169.29 KPI88340.1 - 0.0068 16.9 0.0 0.11 13.0 0.0 2.7 2 1 0 2 2 2 1 PH domain TPR_2 PF07719.17 KPI88341.1 - 0.0033 17.4 1.4 0.18 12.0 0.3 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI88341.1 - 0.0061 16.3 0.2 5.4 7.0 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI88341.1 - 0.014 15.6 3.7 0.041 14.2 2.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Prefoldin_2 PF01920.20 KPI88342.1 - 2.2e-12 46.9 2.1 2.8e-12 46.5 2.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 KPI88342.1 - 3.4e-06 27.0 4.0 0.0002 21.3 0.9 2.1 2 0 0 2 2 2 2 Prefoldin subunit DUF5082 PF16888.5 KPI88342.1 - 0.0011 19.2 1.0 0.29 11.4 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5082) CLZ PF16526.5 KPI88342.1 - 0.0061 16.9 4.0 0.061 13.7 1.4 2.1 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels KfrA_N PF11740.8 KPI88342.1 - 0.0069 17.1 0.8 0.0092 16.6 0.8 1.2 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term DUF4140 PF13600.6 KPI88342.1 - 0.0094 16.4 1.9 3.1 8.3 0.3 2.1 2 0 0 2 2 2 2 N-terminal domain of unknown function (DUF4140) XRCC4 PF06632.12 KPI88342.1 - 0.012 14.5 2.0 0.012 14.5 2.0 1.4 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CdvA PF18822.1 KPI88342.1 - 0.013 15.3 1.9 0.02 14.7 1.9 1.4 1 1 0 1 1 1 0 CdvA-like coiled-coil domain Baculo_PEP_C PF04513.12 KPI88342.1 - 0.014 15.4 0.4 0.034 14.2 0.4 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus WASH_WAHD PF11945.8 KPI88342.1 - 0.019 14.5 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 WAHD domain of WASH complex STAT_alpha PF01017.20 KPI88342.1 - 0.026 14.4 0.4 0.036 14.0 0.4 1.1 1 0 0 1 1 1 0 STAT protein, all-alpha domain V_ATPase_I PF01496.19 KPI88342.1 - 0.028 12.4 0.6 0.031 12.2 0.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 KPI88342.1 - 0.04 14.0 8.6 0.18 11.8 8.2 1.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein PEP-utilisers_N PF05524.13 KPI88342.1 - 0.045 13.9 0.9 0.087 13.0 0.3 1.7 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal FapA PF03961.13 KPI88342.1 - 0.047 12.3 1.1 0.052 12.2 1.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 KPI88342.1 - 0.048 14.1 1.5 8.6 6.8 0.5 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Nup54 PF13874.6 KPI88342.1 - 0.076 13.1 0.9 1.4 9.0 0.4 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 HR1 PF02185.16 KPI88342.1 - 0.098 12.8 4.8 1 9.5 0.6 2.1 2 0 0 2 2 2 0 Hr1 repeat CENP-Q PF13094.6 KPI88342.1 - 0.11 12.7 6.2 0.24 11.6 3.6 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit XhlA PF10779.9 KPI88342.1 - 0.13 12.5 4.5 3 8.1 0.4 2.1 2 0 0 2 2 2 0 Haemolysin XhlA Spc24 PF08286.11 KPI88342.1 - 0.2 11.9 5.9 0.37 11.1 2.7 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SlyX PF04102.12 KPI88342.1 - 0.47 11.1 3.2 7 7.4 0.1 2.2 2 0 0 2 2 2 0 SlyX HalX PF08663.10 KPI88342.1 - 0.48 10.8 7.8 1.5 9.2 2.6 2.2 2 0 0 2 2 2 0 HalX domain ZapB PF06005.12 KPI88342.1 - 0.52 10.8 7.4 13 6.3 5.2 2.1 2 0 0 2 2 2 0 Cell division protein ZapB Pkinase PF00069.25 KPI88343.1 - 1.5e-07 31.1 0.0 1.8e-06 27.5 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88343.1 - 0.096 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Cyclin_N PF00134.23 KPI88344.1 - 2.8e-07 30.3 0.0 0.00021 21.0 0.0 2.7 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB_C_1 PF18542.1 KPI88344.1 - 0.069 13.2 0.5 0.24 11.5 0.5 1.9 1 0 0 1 1 1 0 Transcription factor IIB C-terminal module 1 zf-DNL PF05180.12 KPI88345.1 - 4.2e-27 93.9 0.1 6.3e-27 93.3 0.1 1.3 1 0 0 1 1 1 1 DNL zinc finger DUF1364 PF07102.12 KPI88345.1 - 0.15 11.9 0.9 0.44 10.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1364) Ank_2 PF12796.7 KPI88346.1 - 1.7e-07 31.8 0.1 0.038 14.6 0.0 3.8 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KPI88346.1 - 4.5e-05 23.9 1.0 1.1 9.9 0.0 4.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI88346.1 - 0.01 16.3 1.0 2.6 8.9 0.1 4.5 4 0 0 4 4 4 0 Ankyrin repeat DUF2722 PF10846.8 KPI88347.1 - 0.081 11.9 9.2 0.09 11.7 9.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Coat_F PF07875.12 KPI88347.1 - 0.63 10.3 10.4 0.95 9.7 10.4 1.3 1 0 0 1 1 1 0 Coat F domain GFO_IDH_MocA PF01408.22 KPI88349.1 - 1.1e-11 45.6 0.1 2.6e-11 44.4 0.1 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA PF01408.22 KPI88350.1 - 6.6e-16 59.2 0.1 1.1e-15 58.5 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 KPI88350.1 - 0.0014 19.2 0.1 0.0036 17.8 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 KPI88350.1 - 0.0094 16.4 0.2 0.018 15.5 0.2 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 KPI88350.1 - 0.045 14.4 0.1 0.092 13.4 0.1 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain CAF1 PF04857.20 KPI88353.1 - 4.8e-70 236.2 0.0 5.8e-70 236.0 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease NMO PF03060.15 KPI88354.1 - 5.6e-41 141.0 0.1 1.3e-40 139.8 0.1 1.5 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 KPI88354.1 - 6.4e-07 28.7 0.0 0.019 14.0 0.4 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KPI88354.1 - 0.0015 17.7 2.7 0.0015 17.7 2.7 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NanE PF04131.14 KPI88354.1 - 0.1 11.8 0.0 0.23 10.6 0.0 1.6 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Kelch_5 PF13854.6 KPI88356.1 - 3.3e-12 46.1 5.6 0.00037 20.4 0.3 5.0 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KPI88356.1 - 1.1e-10 41.0 4.7 0.013 15.1 0.0 5.5 4 1 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 KPI88356.1 - 9.9e-10 38.4 6.3 0.67 10.3 0.0 5.8 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 KPI88356.1 - 5.9e-07 29.4 8.2 3.8 7.6 0.0 6.6 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KPI88356.1 - 3.6e-05 23.6 9.6 6.2 7.0 0.1 6.2 5 1 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 KPI88356.1 - 0.0001 22.5 18.8 0.0034 17.6 0.2 7.1 7 0 0 7 7 7 1 Galactose oxidase, central domain tRNA_bind PF01588.20 KPI88357.1 - 1.9e-13 50.3 0.2 2.5e-13 50.0 0.2 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain zf-RanBP PF00641.18 KPI88357.1 - 1.9e-06 27.1 2.4 3.3e-06 26.3 2.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DZR PF12773.7 KPI88357.1 - 0.022 14.8 1.4 0.036 14.1 1.4 1.4 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 KPI88357.1 - 0.48 10.2 4.0 0.97 9.2 4.0 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Lactamase_B PF00753.27 KPI88358.1 - 3.4e-09 37.0 1.0 7e-07 29.4 0.6 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily PI-PLC-X PF00388.19 KPI88359.1 - 0.0005 19.7 0.2 0.004 16.8 0.0 2.6 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain YqjK PF13997.6 KPI88359.1 - 0.15 12.4 0.2 0.57 10.5 0.2 2.0 1 0 0 1 1 1 0 YqjK-like protein PAP2 PF01569.21 KPI88360.1 - 1.3e-07 31.5 1.1 3.1e-07 30.2 1.1 1.7 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 KPI88360.1 - 0.014 15.5 4.2 0.44 10.7 0.1 2.7 3 0 0 3 3 3 0 Divergent PAP2 family RTA1 PF04479.13 KPI88360.1 - 0.076 12.6 4.5 1.2 8.6 0.3 3.1 1 1 2 3 3 3 0 RTA1 like protein ThiF PF00899.21 KPI88361.1 - 4e-82 275.2 0.0 4.6e-60 203.0 0.0 2.9 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KPI88361.1 - 2.3e-64 217.8 0.1 3.3e-64 217.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 KPI88361.1 - 8.5e-13 48.8 0.0 2e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain Shikimate_DH PF01488.20 KPI88361.1 - 0.0048 17.0 0.2 4.3 7.4 0.0 2.6 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase E1_FCCH PF16190.5 KPI88361.1 - 0.012 15.8 0.0 0.036 14.2 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 FCCH domain Kinesin PF00225.23 KPI88362.1 - 2.7e-87 292.8 0.0 1.2e-86 290.7 0.0 2.1 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI88362.1 - 2.8e-17 63.0 0.1 1.8e-16 60.4 0.1 2.4 1 1 0 1 1 1 1 Microtubule binding Pox_F16 PF04708.12 KPI88362.1 - 0.025 14.0 0.3 0.067 12.6 0.3 1.7 1 0 0 1 1 1 0 Poxvirus F16 protein ssDBP PF17878.1 KPI88362.1 - 0.14 12.4 0.8 0.28 11.5 0.8 1.4 1 0 0 1 1 1 0 Single-stranded DNA-binding protein STAT_alpha PF01017.20 KPI88362.1 - 0.35 10.7 20.1 0.24 11.3 4.9 3.4 3 0 0 3 3 3 0 STAT protein, all-alpha domain MYCBPAP PF14646.6 KPI88363.1 - 3.7e-11 42.6 0.4 1.7e-10 40.5 0.4 1.9 1 1 0 1 1 1 1 MYCBP-associated protein family Tmemb_9 PF05434.11 KPI88366.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 TMEM9 DUF5089 PF17002.5 KPI88367.1 - 0.017 15.0 1.4 0.029 14.2 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) BING4CT PF08149.11 KPI88368.1 - 3.2e-29 100.6 0.0 1.3e-28 98.6 0.0 2.2 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.32 KPI88368.1 - 2.5e-08 34.4 0.4 1.8e-05 25.4 0.0 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat Sec10 PF07393.11 KPI88369.1 - 9.3e-31 107.0 0.0 2.1e-25 89.3 0.0 3.2 2 1 0 3 3 3 2 Exocyst complex component Sec10 RecC_C PF17946.1 KPI88369.1 - 0.038 13.8 3.6 0.12 12.1 0.6 2.4 2 0 0 2 2 2 0 RecC C-terminal domain DUF1831 PF08866.10 KPI88369.1 - 0.086 13.3 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 Putative amino acid metabolism CitMHS PF03600.16 KPI88370.1 - 0.062 12.5 0.3 0.61 9.2 1.7 1.7 2 0 0 2 2 2 0 Citrate transporter Neur_chan_memb PF02932.16 KPI88370.1 - 0.31 11.1 9.8 0.9 9.5 9.4 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Shisa PF13908.6 KPI88370.1 - 0.45 10.7 0.0 0.45 10.7 0.0 2.8 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator SID-1_RNA_chan PF13965.6 KPI88370.1 - 0.66 8.3 13.6 0.76 8.1 0.8 3.2 2 1 1 3 3 3 0 dsRNA-gated channel SID-1 VIR_N PF15912.5 KPI88370.1 - 1.2 8.7 18.9 2.6 7.6 18.9 1.6 1 0 0 1 1 1 0 Virilizer, N-terminal CDC45 PF02724.14 KPI88370.1 - 1.3 7.3 33.0 0.81 7.9 31.3 1.5 2 0 0 2 2 2 0 CDC45-like protein LAP1C PF05609.12 KPI88370.1 - 3.9 6.5 22.8 6.5 5.7 22.8 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SLC12 PF03522.15 KPI88370.1 - 6.1 5.8 16.2 9.5 5.1 16.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S64 PF08192.11 KPI88370.1 - 6.8 5.0 7.3 10 4.5 7.3 1.4 1 0 0 1 1 1 0 Peptidase family S64 DIM1 PF02966.16 KPI88371.1 - 7e-31 106.8 0.3 7.7e-27 93.7 0.1 2.1 2 0 0 2 2 2 2 Mitosis protein DIM1 GFO_IDH_MocA PF01408.22 KPI88373.1 - 1.9e-09 38.4 0.4 6.1e-09 36.7 0.1 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold AAA_33 PF13671.6 KPI88373.1 - 0.0038 17.4 0.1 0.009 16.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain PriCT_2 PF08707.11 KPI88373.1 - 0.11 12.9 0.6 0.4 11.1 0.2 2.1 2 0 0 2 2 2 0 Primase C terminal 2 (PriCT-2) PriCT_2 PF08707.11 KPI88374.1 - 3.4e-16 59.4 1.3 8.7e-16 58.1 1.3 1.8 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) PPL5 PF18168.1 KPI88374.1 - 9.4e-08 31.7 0.3 1.5e-05 24.5 0.0 2.7 1 1 1 2 2 2 2 Prim-pol family 5 Thiolase_N PF00108.23 KPI88375.1 - 5.7e-15 55.4 0.5 1.2e-12 47.8 0.1 2.4 2 0 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 KPI88375.1 - 8.3e-13 48.1 0.1 1.8e-11 43.8 0.1 2.6 1 1 1 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KPI88375.1 - 6.1e-08 32.5 7.2 3.3e-06 26.9 5.1 2.6 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KPI88375.1 - 0.076 12.9 1.8 4.1 7.3 1.3 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 KPI88375.1 - 0.67 10.0 4.5 5 7.2 0.3 3.6 3 1 0 3 3 3 0 Beta-ketoacyl synthase, C-terminal domain COX17 PF05051.13 KPI88376.1 - 6.5e-06 26.4 0.4 1e-05 25.8 0.4 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) AMP-binding PF00501.28 KPI88377.1 - 2e-27 95.9 0.1 2.5e-27 95.6 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KPI88377.1 - 2.1e-19 70.3 0.6 3.6e-19 69.5 0.6 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AAA PF00004.29 KPI88379.1 - 4.1e-38 130.8 0.0 7.2e-38 130.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI88379.1 - 6.8e-12 45.0 0.0 1.5e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 KPI88379.1 - 5.3e-08 32.8 0.0 1.7e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 KPI88379.1 - 2.4e-06 27.6 0.1 1.5e-05 25.0 0.1 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI88379.1 - 7.8e-06 25.7 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KPI88379.1 - 3.7e-05 24.0 0.3 0.013 15.8 0.1 3.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 KPI88379.1 - 0.00013 22.4 4.9 0.021 15.2 0.0 4.3 3 1 1 4 4 4 1 AAA ATPase domain TIP49 PF06068.13 KPI88379.1 - 0.00078 18.8 0.0 0.0016 17.7 0.0 1.3 1 1 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KPI88379.1 - 0.006 16.0 0.1 0.013 14.9 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KPI88379.1 - 0.009 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 KPI88379.1 - 0.011 16.3 0.0 0.024 15.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KPI88379.1 - 0.019 15.1 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KPI88379.1 - 0.023 14.9 0.0 0.067 13.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain DUF1517 PF07466.11 KPI88379.1 - 0.081 13.0 0.1 0.71 10.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1517) AAA_14 PF13173.6 KPI88379.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KPI88379.1 - 0.11 11.9 0.0 2.9 7.3 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein TsaE PF02367.17 KPI88379.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 KPI88379.1 - 0.13 11.4 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 KPI88379.1 - 0.13 12.7 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KPI88379.1 - 0.17 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 KPI88379.1 - 0.19 11.4 0.0 2 8.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 KPI88379.1 - 0.7 9.4 3.1 0.88 9.1 0.0 2.6 2 1 1 3 3 3 0 AAA domain Ecotin PF03974.13 KPI88380.1 - 2.5e-40 137.2 0.0 3.2e-40 136.9 0.0 1.0 1 0 0 1 1 1 1 Ecotin Ecotin PF03974.13 KPI88381.1 - 2.2e-32 111.6 0.0 3.5e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Ecotin Pox_A_type_inc PF04508.12 KPI88383.1 - 0.0023 17.7 0.6 4.6 7.3 0.1 3.4 3 0 0 3 3 3 2 Viral A-type inclusion protein repeat APG6_N PF17675.1 KPI88383.1 - 0.0082 16.7 16.5 0.0082 16.7 16.5 5.1 4 2 1 5 5 5 3 Apg6 coiled-coil region PI_PP_I PF18363.1 KPI88383.1 - 0.056 13.6 1.8 0.4 10.9 0.1 2.9 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain YabA PF06156.13 KPI88383.1 - 0.15 12.7 0.3 0.15 12.7 0.3 6.1 4 1 2 6 6 6 0 Initiation control protein YabA SLATT_5 PF18160.1 KPI88383.1 - 0.7 9.2 3.4 1.5 8.1 0.2 2.7 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 Cauli_DNA-bind PF03310.13 KPI88383.1 - 0.8 9.8 0.0 0.8 9.8 0.0 3.3 4 0 0 4 4 4 0 Caulimovirus DNA-binding protein Connexin40_C PF16791.5 KPI88383.1 - 6.6 8.1 7.0 71 4.7 3.8 3.0 2 0 0 2 2 2 0 Connexin 40 C-terminal domain PRRSV_2b PF07069.11 KPI88384.1 - 0.077 13.5 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b TolA_bind_tri PF16331.5 KPI88385.1 - 0.0033 17.5 1.5 0.0033 17.5 1.5 4.7 5 1 1 6 6 6 1 TolA binding protein trimerisation Bcr-Abl_Oligo PF09036.10 KPI88385.1 - 1.3 9.1 4.9 0.4 10.7 0.8 2.4 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain PknG_rubred PF16919.5 KPI88385.1 - 1.9 8.7 8.1 0.43 10.7 3.2 2.5 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain SPC22 PF04573.12 KPI88387.1 - 2.1e-15 56.6 0.0 1.9e-10 40.5 0.0 3.1 3 0 0 3 3 3 3 Signal peptidase subunit LLC1 PF14945.6 KPI88388.1 - 9.1e-06 26.2 0.9 0.01 16.4 0.1 2.3 2 0 0 2 2 2 2 Normal lung function maintenance, Low in Lung Cancer 1 protein FAM183 PF14886.6 KPI88388.1 - 0.0039 17.9 2.9 0.047 14.4 2.9 2.3 1 1 0 1 1 1 1 FAM183A and FAM183B related ATG16 PF08614.11 KPI88389.1 - 0.00035 20.9 15.7 0.00035 20.9 15.7 5.7 6 1 0 6 6 6 1 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.6 KPI88389.1 - 4.9 7.6 14.1 8.8 6.8 0.3 3.0 1 1 1 2 2 2 0 Snapin/Pallidin V_ATPase_I PF01496.19 KPI88389.1 - 5.9 4.7 6.0 11 3.7 6.0 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CRAL_TRIO PF00650.20 KPI88391.1 - 3.2e-16 59.5 0.1 6.2e-15 55.3 0.0 2.6 2 1 0 2 2 2 1 CRAL/TRIO domain CompInhib_SCIN PF11546.8 KPI88392.1 - 0.064 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN Varsurf_PPLC PF03490.13 KPI88392.1 - 0.14 12.1 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Variant-surface-glycoprotein phospholipase C Kelch_4 PF13418.6 KPI88396.1 - 1.8e-19 69.5 5.4 1e-05 25.4 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KPI88396.1 - 2e-16 59.5 0.7 0.0011 18.9 0.1 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KPI88396.1 - 6.5e-11 41.8 1.8 0.0048 16.8 0.0 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 KPI88396.1 - 9.1e-11 41.8 16.6 0.0082 16.4 0.0 7.6 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KPI88396.1 - 1.6e-10 40.8 3.9 2.3e-05 24.5 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 KPI88396.1 - 3.2e-09 36.2 5.2 0.0023 17.4 0.0 4.3 4 0 0 4 4 4 3 Kelch motif RAM PF15320.6 KPI88397.1 - 8.3 7.1 7.0 30 5.3 7.0 2.0 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Band_3_cyto PF07565.13 KPI88398.1 - 6.4 6.5 5.5 1 9.1 1.6 1.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF2871 PF11070.8 KPI88400.1 - 2.4e-39 134.7 5.7 2.7e-39 134.5 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2871) COX6C PF02937.15 KPI88400.1 - 0.2 11.8 2.1 9.5 6.4 0.1 3.0 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIc Amastin PF07344.11 KPI88401.1 - 6.1e-28 97.6 18.0 5.5e-15 55.5 9.4 2.2 2 0 0 2 2 2 2 Amastin surface glycoprotein Pho86 PF11124.8 KPI88401.1 - 1 8.7 4.5 2.6 7.5 0.7 2.4 2 0 0 2 2 2 0 Inorganic phosphate transporter Pho86 Methyltransf_16 PF10294.9 KPI88402.1 - 3.9e-09 36.5 0.0 0.00013 21.7 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase PH PF00169.29 KPI88403.1 - 6.4e-08 33.1 0.0 2.5e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 KPI88403.1 - 0.0042 16.9 0.0 0.22 11.3 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 KPI88403.1 - 0.0079 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 PH domain DHHC PF01529.20 KPI88404.1 - 4.8e-26 91.4 9.8 4.8e-26 91.4 9.8 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF4547 PF15080.6 KPI88404.1 - 0.0098 15.5 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4547) DUF4713 PF15831.5 KPI88404.1 - 0.15 12.5 0.0 0.15 12.5 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4713) AAA_33 PF13671.6 KPI88405.1 - 8e-07 29.3 0.5 7.6e-06 26.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KPI88405.1 - 9.6e-05 21.7 0.0 0.00027 20.3 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 KPI88405.1 - 0.00044 20.8 0.1 0.0013 19.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI88405.1 - 0.00064 20.1 0.3 0.0032 17.9 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain APS_kinase PF01583.20 KPI88405.1 - 0.0013 18.7 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.6 KPI88405.1 - 0.0046 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KPI88405.1 - 0.028 14.1 0.0 0.077 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytidylate_kin PF02224.18 KPI88405.1 - 0.031 14.0 0.1 0.061 13.1 0.1 1.5 1 0 0 1 1 1 0 Cytidylate kinase PRK PF00485.18 KPI88405.1 - 0.043 13.5 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family CbiA PF01656.23 KPI88405.1 - 0.059 13.4 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 KPI88405.1 - 0.061 13.8 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 KPI88405.1 - 0.066 13.4 0.0 0.22 11.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 KPI88405.1 - 0.096 12.6 0.1 0.31 10.9 0.1 1.9 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 KPI88405.1 - 0.15 11.8 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 KPI88405.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 KPI88405.1 - 0.19 12.1 0.0 1.9 8.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain TYW3 PF02676.14 KPI88406.1 - 1.6e-54 184.5 0.0 2.6e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 Prefoldin_2 PF01920.20 KPI88407.1 - 7.5e-21 74.1 0.9 9.7e-21 73.7 0.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit DASH_Dad3 PF08656.10 KPI88407.1 - 0.018 15.1 2.6 0.023 14.7 0.7 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad3 SlyX PF04102.12 KPI88407.1 - 0.019 15.6 1.2 0.4 11.3 0.0 2.2 2 0 0 2 2 2 0 SlyX APG6_N PF17675.1 KPI88407.1 - 0.024 15.2 4.0 2.6 8.6 0.1 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region FliD_C PF07195.12 KPI88407.1 - 0.024 14.0 0.7 0.11 11.9 0.7 1.9 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Spc24 PF08286.11 KPI88407.1 - 0.19 12.0 2.7 3.1 8.1 0.3 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF2165 PF09933.9 KPI88408.1 - 0.14 12.2 1.5 0.22 11.6 1.5 1.3 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) AP_endonuc_2 PF01261.24 KPI88409.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel zf-CCCH PF00642.24 KPI88412.1 - 5.1e-17 61.3 34.6 0.00052 19.8 0.6 5.8 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI88412.1 - 1.1e-16 60.3 29.9 5.2e-07 29.5 1.6 5.8 5 1 0 5 5 5 4 Zinc finger domain zf-CCCH_4 PF18044.1 KPI88412.1 - 1.7e-11 43.6 27.0 4.3e-07 29.6 0.6 5.1 5 0 0 5 5 5 4 CCCH-type zinc finger Torus PF16131.5 KPI88412.1 - 3.1e-11 43.9 21.5 0.001 19.7 0.5 5.2 1 1 4 5 5 5 4 Torus domain zf-CCCH_3 PF15663.5 KPI88412.1 - 6.8e-07 29.5 13.3 9.7e-07 29.0 6.5 2.6 2 1 1 3 3 3 1 Zinc-finger containing family zf-CCHC PF00098.23 KPI88412.1 - 3.7e-06 26.7 9.6 5.1e-05 23.2 0.3 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 KPI88412.1 - 3.6e-05 23.5 4.7 0.00029 20.6 0.4 3.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCCH_2 PF14608.6 KPI88412.1 - 0.00085 19.7 1.5 0.00085 19.7 1.5 6.3 7 0 0 7 7 7 3 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.9 KPI88412.1 - 4.4 7.1 9.0 1.3 8.8 0.1 3.8 3 0 0 3 3 3 0 Putative zinc-finger domain zf-UBR PF02207.20 KPI88414.1 - 3e-16 59.3 9.7 3e-16 59.3 9.7 2.7 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) HeH PF12949.7 KPI88414.1 - 0.019 14.7 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 HeH/LEM domain CBP_BcsF PF11120.8 KPI88414.1 - 0.14 12.3 3.1 6 7.1 0.3 3.4 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF BLOC1S3 PF15753.5 KPI88414.1 - 3.5 7.7 5.2 1.7 8.8 0.8 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 ACBP PF00887.19 KPI88415.1 - 3.2e-23 81.8 1.0 6.9e-23 80.7 1.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein Peptidase_S9_N PF02897.15 KPI88417.1 - 6.8e-110 367.7 0.2 8.5e-110 367.4 0.2 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 KPI88417.1 - 2.3e-65 220.1 0.0 3.6e-65 219.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF4464 PF14713.6 KPI88418.1 - 3.6e-86 288.4 0.1 4.1e-86 288.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) BMFP PF04380.13 KPI88418.1 - 0.028 14.9 0.2 0.056 13.9 0.2 1.5 1 0 0 1 1 1 0 Membrane fusogenic activity DUF4164 PF13747.6 KPI88419.1 - 0.052 13.8 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) MT PF12777.7 KPI88420.1 - 1.7e-10 40.4 0.3 1.7e-10 40.4 0.3 2.9 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor Prefoldin PF02996.17 KPI88421.1 - 1.5e-10 41.0 0.0 1.7e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Prefoldin subunit AAA PF00004.29 KPI88422.1 - 0.00063 20.2 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI88422.1 - 0.012 16.0 0.1 0.051 14.0 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain Prosystemin PF07376.11 KPI88422.1 - 0.021 14.3 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Prosystemin Zeta_toxin PF06414.12 KPI88422.1 - 0.039 13.2 0.0 0.073 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 KPI88422.1 - 0.11 13.0 0.2 0.82 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KPI88422.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DEAD PF00270.29 KPI88423.1 - 1.1e-27 96.9 0.1 2.4e-27 95.8 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88423.1 - 3.3e-20 72.5 0.1 1.7e-19 70.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88423.1 - 0.00092 19.3 0.0 0.0023 18.0 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UPF0160 PF03690.13 KPI88424.1 - 2.7e-124 414.9 0.0 3.1e-124 414.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ras PF00071.22 KPI88425.1 - 3.3e-35 121.1 0.2 5.6e-25 87.8 0.0 2.6 2 1 0 2 2 2 2 Ras family Roc PF08477.13 KPI88425.1 - 4.6e-20 72.0 0.8 2.1e-18 66.7 0.3 2.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI88425.1 - 0.0001 21.8 0.2 0.004 16.6 0.1 2.7 2 1 0 2 2 2 1 ADP-ribosylation factor family AAA_7 PF12775.7 KPI88425.1 - 0.061 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PET117 PF15786.5 KPI88426.1 - 0.00013 22.2 0.0 0.00015 21.9 0.0 1.2 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF4536 PF15055.6 KPI88426.1 - 0.024 14.8 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) UPF0242 PF06785.11 KPI88427.1 - 0.31 11.1 15.5 0.56 10.3 15.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Nucleo_P87 PF07267.11 KPI88427.1 - 1.7 7.4 10.3 3 6.6 10.3 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PhoLip_ATPase_C PF16212.5 KPI88429.1 - 4.3e-52 177.3 25.3 4.3e-52 177.3 25.3 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KPI88429.1 - 3.2e-19 68.4 0.3 7.7e-19 67.1 0.3 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KPI88429.1 - 2.5e-08 34.4 0.2 0.0038 17.5 0.1 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KPI88429.1 - 0.0033 17.5 0.1 0.045 13.8 0.0 2.7 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KPI88429.1 - 0.0044 16.6 0.1 0.015 14.8 0.1 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KPI88429.1 - 0.043 13.6 0.2 0.087 12.5 0.2 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PgpA PF04608.13 KPI88429.1 - 0.079 13.0 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Phosphatidylglycerophosphatase A Arrestin_N PF00339.29 KPI88430.1 - 1.3e-07 31.8 0.0 0.0029 17.7 0.0 2.8 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 KPI88430.1 - 0.00069 19.2 1.4 0.0028 17.2 0.1 2.5 3 0 0 3 3 3 1 SpoOM protein LDB19 PF13002.7 KPI88430.1 - 0.0021 17.8 0.0 0.02 14.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin_N terminal like RNA_pol_Rpc4 PF05132.14 KPI88430.1 - 2.3 8.6 7.5 0.6 10.5 0.6 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Eapp_C PF10238.9 KPI88430.1 - 6.2 6.9 9.1 16 5.5 1.3 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein Utp21 PF04192.12 KPI88431.1 - 1.3e-23 83.7 0.0 2.3e-23 82.9 0.0 1.4 1 1 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 KPI88431.1 - 5.3e-14 52.4 12.3 0.002 18.9 0.0 8.9 10 0 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI88431.1 - 1.5e-11 44.4 0.2 0.0032 17.7 0.0 5.4 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KPI88431.1 - 4.7e-09 36.2 2.5 3e-05 23.7 0.2 3.0 2 2 0 2 2 2 2 PQQ-like domain Nup160 PF11715.8 KPI88431.1 - 1.6e-05 23.8 1.7 0.64 8.6 0.1 4.0 2 2 1 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 KPI88431.1 - 0.0011 17.9 3.3 0.052 12.5 0.1 3.5 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Hira PF07569.11 KPI88431.1 - 0.0018 18.0 2.7 0.64 9.7 0.1 4.3 4 1 1 5 5 5 1 TUP1-like enhancer of split WD40_like PF17005.5 KPI88431.1 - 0.0023 17.3 0.0 0.0099 15.2 0.0 1.9 2 0 0 2 2 2 1 WD40-like domain Utp12 PF04003.12 KPI88431.1 - 0.026 14.8 0.0 0.059 13.7 0.0 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family DUF4023 PF13215.6 KPI88432.1 - 0.052 13.6 0.5 0.13 12.3 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) LRR_6 PF13516.6 KPI88433.1 - 3.1e-36 120.4 81.8 0.00015 21.6 0.1 20.5 22 0 0 22 22 22 11 Leucine Rich repeat LRR_4 PF12799.7 KPI88433.1 - 7.5e-16 58.0 57.7 1.2e-05 25.6 0.1 12.9 11 4 2 13 13 13 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88433.1 - 8.8e-10 38.2 54.8 5.3e-05 22.9 1.2 12.7 9 5 6 15 15 15 8 Leucine rich repeat LRR_1 PF00560.33 KPI88433.1 - 3.9e-09 35.8 30.5 7.6 7.5 0.0 14.7 16 0 0 16 16 16 2 Leucine Rich Repeat WD40 PF00400.32 KPI88434.1 - 0.0012 19.6 1.8 1.1 10.2 0.2 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI88434.1 - 0.0051 17.1 0.0 2.1 8.7 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KPI88434.1 - 0.015 15.8 0.1 0.21 12.1 0.1 2.6 2 0 0 2 2 2 0 PQQ-like domain Lgl_C PF08596.10 KPI88434.1 - 0.19 10.4 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal Pkinase PF00069.25 KPI88435.1 - 2e-48 165.1 0.0 1.8e-25 89.8 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88435.1 - 7.1e-20 71.4 0.0 2.9e-12 46.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KPI88435.1 - 0.0058 16.6 0.1 0.043 13.7 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI88435.1 - 0.066 12.5 0.0 13 5.0 0.0 3.0 3 0 0 3 3 3 0 Kinase-like zf-LITAF-like PF10601.9 KPI88436.1 - 0.15 12.3 0.1 0.15 12.3 0.1 3.0 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain DUF4238 PF14022.6 KPI88437.1 - 2.1 7.8 7.1 3 7.3 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) TPR_14 PF13428.6 KPI88439.1 - 4.3e-10 39.6 57.1 0.016 16.0 3.8 12.7 7 4 8 15 15 15 5 Tetratricopeptide repeat HAT PF02184.16 KPI88439.1 - 3e-06 27.1 13.9 0.24 11.4 0.5 5.5 5 0 0 5 5 5 3 HAT (Half-A-TPR) repeat DUF2063 PF09836.9 KPI88439.1 - 0.0008 19.6 1.4 0.0026 18.0 0.2 2.7 2 0 0 2 2 1 1 Putative DNA-binding domain NRDE-2 PF08424.10 KPI88439.1 - 0.0066 15.6 3.4 0.44 9.6 0.1 3.7 3 1 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_19 PF14559.6 KPI88439.1 - 0.021 15.3 27.4 0.15 12.6 1.6 6.8 8 1 0 8 8 7 0 Tetratricopeptide repeat YbfN PF13982.6 KPI88439.1 - 0.078 13.3 0.4 4 7.8 0.1 3.0 2 0 0 2 2 2 0 YbfN-like lipoprotein TPR_17 PF13431.6 KPI88439.1 - 0.16 12.4 9.6 20 5.9 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KPI88439.1 - 0.66 10.0 9.0 4.1 7.4 0.1 5.2 6 1 0 6 6 6 0 Mad3/BUB1 homology region 1 TPR_7 PF13176.6 KPI88439.1 - 0.95 9.6 7.6 3.5 7.9 0.4 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DinB_2 PF12867.7 KPI88439.1 - 2.9 8.4 10.6 5.2 7.6 0.0 4.3 3 1 1 4 4 4 0 DinB superfamily TPR_2 PF07719.17 KPI88439.1 - 8.2 6.8 16.4 6.8 7.1 2.1 5.9 6 1 1 7 7 7 0 Tetratricopeptide repeat Arf PF00025.21 KPI88440.1 - 9.6e-14 51.2 0.0 2.1e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family PH PF00169.29 KPI88440.1 - 2e-09 37.9 0.1 5e-09 36.6 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KPI88440.1 - 0.0021 18.3 1.9 0.0036 17.5 0.3 2.4 3 0 0 3 3 3 1 Pleckstrin homology domain SRPRB PF09439.10 KPI88440.1 - 0.0021 17.5 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit CHAP PF05257.16 KPI88441.1 - 9.5e-13 48.5 0.1 1.9e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 CHAP domain SET PF00856.28 KPI88442.1 - 3.5e-10 40.5 0.0 1.9e-09 38.2 0.0 2.2 1 1 0 1 1 1 1 SET domain DUF4231 PF14015.6 KPI88442.1 - 0.068 13.6 1.3 0.14 12.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) GHMP_kinases_N PF00288.26 KPI88442.1 - 0.12 12.6 1.9 0.45 10.8 0.1 2.6 2 0 0 2 2 2 0 GHMP kinases N terminal domain sCache_2 PF17200.4 KPI88442.1 - 0.13 12.1 0.1 1.2 9.0 0.1 2.2 1 1 0 1 1 1 0 Single Cache domain 2 C2 PF00168.30 KPI88443.1 - 2.3e-51 172.4 1.1 2.1e-12 47.2 0.0 8.9 9 0 0 9 9 9 7 C2 domain CEP76-C2 PF15627.6 KPI88443.1 - 0.17 11.5 0.4 3.4 7.2 0.1 3.0 3 0 0 3 3 3 0 CEP76 C2 domain C2 PF00168.30 KPI88444.1 - 9.5e-18 64.4 0.0 0.00077 19.7 0.0 4.5 4 0 0 4 4 4 4 C2 domain Sperm_Ag_HE2 PF05324.13 KPI88445.1 - 0.18 12.3 0.2 0.18 12.3 0.2 3.1 3 0 0 3 3 3 0 Sperm antigen HE2 AAA PF00004.29 KPI88447.1 - 6.2e-44 149.6 0.0 1.4e-43 148.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI88447.1 - 9e-15 54.2 0.3 2.8e-14 52.6 0.1 2.0 2 0 0 2 2 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KPI88447.1 - 1.5e-07 31.2 2.2 3.3e-07 30.1 2.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 KPI88447.1 - 2.8e-07 30.6 0.1 9.7e-07 28.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KPI88447.1 - 9.8e-07 29.0 0.0 2.7e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KPI88447.1 - 1.2e-06 29.0 0.3 8.4e-05 23.0 0.0 2.9 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KPI88447.1 - 7.7e-06 26.2 3.9 0.01 16.1 0.0 3.3 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 KPI88447.1 - 1.9e-05 24.5 0.0 5e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KPI88447.1 - 0.00088 19.8 0.3 0.013 16.0 0.0 2.7 3 1 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 KPI88447.1 - 0.0012 18.7 0.0 0.0033 17.2 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KPI88447.1 - 0.0013 18.9 0.0 0.0033 17.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KPI88447.1 - 0.0019 18.5 0.2 0.014 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 KPI88447.1 - 0.0022 17.4 0.2 0.099 12.0 0.0 2.6 3 0 0 3 3 3 1 KaiC AAA_14 PF13173.6 KPI88447.1 - 0.003 17.6 0.0 0.059 13.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 KPI88447.1 - 0.0034 16.6 0.0 0.016 14.4 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain ADIP PF11559.8 KPI88447.1 - 0.0072 16.4 2.7 0.015 15.4 2.7 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding AAA_25 PF13481.6 KPI88447.1 - 0.0072 15.9 0.3 0.17 11.5 0.0 2.8 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 KPI88447.1 - 0.0074 15.5 0.0 0.4 9.8 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Mg_chelatase PF01078.21 KPI88447.1 - 0.0074 15.7 0.0 0.027 13.9 0.0 1.9 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KPI88447.1 - 0.0089 15.7 1.4 0.051 13.3 0.1 3.0 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_11 PF13086.6 KPI88447.1 - 0.01 15.7 0.2 0.28 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KPI88447.1 - 0.01 15.7 0.0 0.025 14.5 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KPI88447.1 - 0.012 16.0 0.0 0.026 14.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.13 KPI88447.1 - 0.013 14.6 0.1 0.055 12.6 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 KPI88447.1 - 0.014 14.7 0.4 0.16 11.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 KPI88447.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APG6_N PF17675.1 KPI88447.1 - 0.015 15.8 0.5 0.032 14.8 0.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_24 PF13479.6 KPI88447.1 - 0.022 14.5 0.1 0.06 13.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KPI88447.1 - 0.023 14.2 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 KPI88447.1 - 0.025 14.0 0.1 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein DUF4618 PF15397.6 KPI88447.1 - 0.037 13.5 1.0 0.098 12.1 1.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) AAA_19 PF13245.6 KPI88447.1 - 0.042 14.2 2.6 0.49 10.7 0.0 2.9 2 1 1 3 3 3 0 AAA domain DASH_Dad2 PF08654.10 KPI88447.1 - 0.049 14.1 0.5 0.15 12.5 0.5 1.8 1 0 0 1 1 1 0 DASH complex subunit Dad2 Parvo_NS1 PF01057.17 KPI88447.1 - 0.057 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Prot_ATP_OB_N PF17758.1 KPI88447.1 - 0.076 12.7 0.2 0.23 11.1 0.2 1.8 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain DUF2968 PF11180.8 KPI88447.1 - 0.48 10.0 4.6 0.35 10.5 2.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) HECT PF00632.25 KPI88448.1 - 3.8e-61 207.3 0.0 8.5e-61 206.1 0.0 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AOX PF01786.17 KPI88449.1 - 3.8e-72 242.4 0.0 4.6e-72 242.1 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase GCP_C_terminal PF04130.13 KPI88450.1 - 3.7e-41 141.6 0.1 7.4e-41 140.6 0.1 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KPI88450.1 - 2.3e-25 89.9 0.0 8.2e-25 88.0 0.0 2.1 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF309 PF03745.14 KPI88450.1 - 0.038 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF309) Transposase_mut PF00872.18 KPI88450.1 - 0.091 11.6 0.1 0.13 11.1 0.1 1.2 1 0 0 1 1 1 0 Transposase, Mutator family Arf PF00025.21 KPI88451.1 - 3.2e-48 163.5 0.0 3.6e-48 163.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI88451.1 - 1.3e-13 51.2 0.0 2e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI88451.1 - 6.1e-13 48.7 0.0 7.6e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KPI88451.1 - 2.7e-10 40.0 0.0 4e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KPI88451.1 - 1e-09 38.0 2.3 5.7e-07 29.0 0.2 2.6 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 KPI88451.1 - 1.4e-09 38.0 0.0 2e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI88451.1 - 7.8e-07 28.8 0.0 3.5e-05 23.4 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KPI88451.1 - 3.5e-06 26.6 0.0 4.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KPI88451.1 - 2.2e-05 24.0 0.4 0.00018 21.1 0.4 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KPI88451.1 - 0.00051 20.0 0.2 0.071 13.0 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 KPI88451.1 - 0.0014 18.5 0.0 0.016 15.0 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein cobW PF02492.19 KPI88451.1 - 0.01 15.5 0.0 1.4 8.4 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TIR_2 PF13676.6 KPI88451.1 - 0.028 15.0 0.0 0.038 14.6 0.0 1.2 1 0 0 1 1 1 0 TIR domain MobB PF03205.14 KPI88451.1 - 0.039 13.8 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.29 KPI88452.1 - 1.3e-33 116.3 0.1 4.8e-33 114.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88452.1 - 3.1e-30 104.8 0.3 1.5e-28 99.4 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88452.1 - 0.00072 19.6 1.1 0.034 14.2 0.0 3.2 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KPI88452.1 - 0.028 14.7 0.0 23 5.3 0.0 3.4 3 0 0 3 3 3 0 AAA domain Z1 PF10593.9 KPI88452.1 - 0.11 12.0 1.0 0.25 10.8 0.0 2.0 2 0 0 2 2 2 0 Z1 domain AP3D1 PF06375.11 KPI88453.1 - 0.59 10.4 13.9 0.49 10.6 12.9 1.4 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Cytochrom_C1 PF02167.15 KPI88454.1 - 2.8e-76 256.1 0.0 3.2e-76 255.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family Halogen_Hydrol PF10112.9 KPI88456.1 - 0.22 11.5 0.0 0.38 10.8 0.0 1.3 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Met_synt_B12 PF02965.17 KPI88457.1 - 3.6e-104 348.1 0.0 6.3e-104 347.3 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 KPI88457.1 - 1.1e-78 264.7 0.2 3e-78 263.3 0.0 1.8 2 0 0 2 2 2 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 KPI88457.1 - 1.8e-48 165.4 0.1 7.5e-46 156.8 0.1 2.9 4 0 0 4 4 4 2 Pterin binding enzyme B12-binding_2 PF02607.17 KPI88457.1 - 3.8e-23 81.7 0.6 1.1e-22 80.3 0.1 2.2 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.19 KPI88457.1 - 1.8e-20 73.1 0.1 1.2e-19 70.5 0.2 2.4 3 0 0 3 3 3 1 B12 binding domain M16C_assoc PF08367.11 KPI88458.1 - 1.4e-23 83.3 0.0 3e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 KPI88458.1 - 1.7e-18 67.3 0.0 1.2e-12 48.2 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KPI88458.1 - 3.3e-12 46.6 1.4 1.9e-10 40.9 0.0 2.8 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) EF-hand_1 PF00036.32 KPI88459.1 - 4e-27 91.7 9.1 2.1e-06 26.9 0.0 5.9 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 KPI88459.1 - 1.7e-26 92.4 0.1 2.4e-06 27.9 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KPI88459.1 - 3e-24 82.8 5.4 0.00014 21.5 0.1 5.7 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KPI88459.1 - 1.1e-20 73.2 5.0 8.4e-06 25.5 0.3 4.7 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KPI88459.1 - 7.3e-19 66.3 7.8 4.7e-06 25.8 0.0 5.2 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.7 KPI88459.1 - 3.3e-05 23.8 0.1 0.9 9.5 0.0 4.0 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KPI88459.1 - 0.0013 19.0 0.0 0.59 10.5 0.0 3.1 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KPI88459.1 - 0.0014 19.0 1.2 2.6 8.4 0.0 4.1 5 0 0 5 5 5 1 EF-hand domain Dockerin_1 PF00404.18 KPI88459.1 - 0.037 14.2 0.0 4.1 7.7 0.0 3.2 3 0 0 3 3 3 0 Dockerin type I domain Sec7 PF01369.20 KPI88460.1 - 1e-32 113.3 0.0 1.7e-32 112.6 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PAC4 PF16093.5 KPI88460.1 - 0.27 11.5 1.7 29 5.0 0.0 3.9 3 0 0 3 3 3 0 Proteasome assembly chaperone 4 tRNA_Me_trans PF03054.16 KPI88461.1 - 6.4e-41 140.3 0.0 5.5e-33 114.2 0.0 4.0 3 1 0 3 3 3 3 tRNA methyl transferase NAD_synthase PF02540.17 KPI88461.1 - 0.0055 15.8 0.0 0.013 14.6 0.0 1.5 2 0 0 2 2 2 1 NAD synthase PLAC8 PF04749.17 KPI88463.1 - 0.0006 20.8 29.9 0.00092 20.2 29.9 1.5 1 1 0 1 1 1 1 PLAC8 family Pkinase PF00069.25 KPI88464.1 - 1e-45 156.2 0.0 1.5e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88464.1 - 3.8e-31 108.3 0.0 6.3e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI88464.1 - 6.8e-05 22.3 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI88464.1 - 0.021 13.6 0.0 0.021 13.6 0.0 2.2 2 1 0 2 2 2 0 Fungal protein kinase APH PF01636.23 KPI88464.1 - 0.022 14.7 0.1 0.022 14.7 0.1 2.7 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 KPI88467.1 - 2.5e-50 171.3 0.1 1.7e-30 106.3 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88467.1 - 2.9e-38 131.6 0.0 7.4e-22 77.9 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI88467.1 - 0.017 14.4 0.0 1.1 8.5 0.1 2.3 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 KPI88467.1 - 0.044 13.1 0.3 0.43 9.9 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI88467.1 - 0.16 10.7 0.0 0.38 9.5 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase PTPA PF03095.15 KPI88470.1 - 4.4e-92 308.8 0.0 5.4e-92 308.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein NAPRTase_N PF17767.1 KPI88470.1 - 0.013 15.9 0.2 0.027 14.9 0.2 1.5 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain PLDc_2 PF13091.6 KPI88471.1 - 4.3e-10 39.6 0.0 4.4e-06 26.6 0.0 2.8 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KPI88471.1 - 1.1e-07 31.7 0.1 2.1e-06 27.6 0.0 2.8 3 0 0 3 3 3 1 Phospholipase D Active site motif Phage_lysozyme PF00959.19 KPI88471.1 - 0.11 13.0 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Phage lysozyme CIAPIN1 PF05093.13 KPI88474.1 - 1.7e-14 54.1 16.6 5.5e-11 42.9 3.7 2.2 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Pkinase PF00069.25 KPI88476.1 - 3.4e-37 128.2 0.0 9e-14 51.5 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88476.1 - 2.8e-15 56.3 0.0 1.3e-11 44.3 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase RseA_C PF03873.13 KPI88476.1 - 0.013 15.7 0.0 0.08 13.2 0.0 2.4 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain APH PF01636.23 KPI88476.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI88476.1 - 0.09 12.1 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KPI88476.1 - 0.21 10.9 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kelch_3 PF13415.6 KPI88476.1 - 9.8 6.6 7.8 4.7 7.6 0.3 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Homoserine_dh PF00742.19 KPI88477.1 - 9.6e-07 28.9 0.0 1e-06 28.8 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase AFOR_N PF02730.15 KPI88477.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.0 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain Peptidase_M20 PF01546.28 KPI88478.1 - 2.7e-32 112.1 0.0 3.7e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KPI88478.1 - 3.8e-18 65.4 0.0 6.5e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain HECT PF00632.25 KPI88479.1 - 1.3e-88 297.5 0.0 2.1e-88 296.8 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) C1_2 PF03107.16 KPI88479.1 - 3.8e-06 27.1 8.2 8.3e-06 26.0 8.2 1.6 1 0 0 1 1 1 1 C1 domain ZZ PF00569.17 KPI88479.1 - 0.074 12.9 8.3 0.17 11.7 8.3 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type zf-CCCH PF00642.24 KPI88479.1 - 0.32 10.9 5.2 1 9.4 5.2 1.9 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UFC1 PF08694.11 KPI88481.1 - 2e-78 261.3 0.2 2.3e-78 261.2 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 KPI88481.1 - 0.0014 18.3 0.2 0.002 17.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KPI88481.1 - 0.01 16.1 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 0 RWD domain SET PF00856.28 KPI88482.1 - 3.3e-10 40.6 0.0 5.8e-10 39.8 0.0 1.5 2 0 0 2 2 2 1 SET domain CorA PF01544.18 KPI88483.1 - 5.8e-38 130.9 0.5 1.1e-37 129.9 0.5 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SAGA-Tad1 PF12767.7 KPI88483.1 - 0.047 13.4 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit MscS_TM PF12794.7 KPI88483.1 - 6.3 5.6 10.2 0.042 12.7 1.9 1.5 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 FAM199X PF15814.5 KPI88484.1 - 2.8 6.9 6.3 4.5 6.2 6.3 1.2 1 0 0 1 1 1 0 Protein family FAM199X DUF3824 PF12868.7 KPI88484.1 - 4.8 7.8 9.6 9.2 6.9 9.6 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DNA_topoisoIV PF00521.20 KPI88486.1 - 7.1e-101 338.2 0.0 1.3e-100 337.3 0.0 1.4 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KPI88486.1 - 3.8e-32 111.3 1.3 7.2e-32 110.4 1.3 1.5 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM HATPase_c PF02518.26 KPI88486.1 - 1.3e-08 35.3 0.0 4.9e-08 33.5 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_gyraseB PF00204.25 KPI88486.1 - 7.9e-08 32.0 0.0 1.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 KPI88486.1 - 1.4e-06 28.4 0.0 6.2e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 Toprim domain UCH PF00443.29 KPI88487.1 - 4.5e-40 137.8 0.0 7.3e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 KPI88487.1 - 8e-11 41.7 0.0 1.2e-05 24.8 0.0 2.7 2 1 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 KPI88487.1 - 9.5e-10 38.6 0.3 3e-08 33.6 0.3 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CorA PF01544.18 KPI88488.1 - 6.3e-28 97.9 5.6 3.2e-25 89.0 5.6 2.3 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SHOCT PF09851.9 KPI88488.1 - 6.9e-05 22.5 0.1 0.00012 21.7 0.1 1.4 1 0 0 1 1 1 1 Short C-terminal domain AAR2 PF05282.11 KPI88488.1 - 0.18 11.2 5.2 0.44 9.9 5.2 1.6 1 0 0 1 1 1 0 AAR2 protein Apt1 PF10351.9 KPI88488.1 - 8.6 5.1 18.2 0.58 8.9 12.5 1.8 2 0 0 2 2 2 0 Golgi-body localisation protein domain Macoilin PF09726.9 KPI88488.1 - 8.9 4.7 13.7 15 4.0 13.7 1.3 1 0 0 1 1 1 0 Macoilin family MIF4G PF02854.19 KPI88489.1 - 2.3e-11 43.7 0.0 4.5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain Actin PF00022.19 KPI88490.1 - 2e-93 313.2 0.0 4.4e-93 312.1 0.0 1.5 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KPI88490.1 - 0.00011 21.2 0.0 0.013 14.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein EF-hand_7 PF13499.6 KPI88491.1 - 0.0019 18.6 0.0 0.03 14.8 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KPI88491.1 - 0.057 13.4 0.0 0.74 9.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain DUF3678 PF12435.8 KPI88491.1 - 3.3 7.2 0.0 3.3 7.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) NIF PF03031.18 KPI88492.1 - 0.0035 17.1 0.0 0.05 13.4 0.0 2.2 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase WHEP-TRS PF00458.20 KPI88493.1 - 0.00098 19.2 0.1 0.0025 17.9 0.1 1.7 1 0 0 1 1 1 1 WHEP-TRS domain RabGAP-TBC PF00566.18 KPI88494.1 - 3.2e-07 30.2 0.1 6.8e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SlyX PF04102.12 KPI88494.1 - 0.05 14.2 3.2 0.15 12.7 3.2 1.8 1 0 0 1 1 1 0 SlyX 2OG-FeII_Oxy PF03171.20 KPI88495.1 - 0.00018 21.9 0.0 0.38 11.3 0.0 2.4 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily Actin PF00022.19 KPI88496.1 - 2.3e-66 224.1 0.0 3.4e-64 217.0 0.0 2.0 1 1 0 1 1 1 1 Actin DUF1796 PF08795.10 KPI88497.1 - 5.8e-48 163.0 0.0 1.3e-47 161.9 0.0 1.6 1 1 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) Nop PF01798.18 KPI88498.1 - 6.5e-81 271.2 0.5 9e-81 270.7 0.5 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KPI88498.1 - 0.00014 22.2 0.3 0.4 11.1 0.0 2.9 1 1 1 2 2 2 2 NOP5NT (NUC127) domain RHH_6 PF16762.5 KPI88498.1 - 0.42 11.3 2.5 43 4.8 0.1 3.3 2 1 1 3 3 3 0 Ribbon-helix-helix domain TMEM164 PF14808.6 KPI88499.1 - 2.6e-07 30.3 1.6 2.6e-07 30.3 1.6 1.5 2 0 0 2 2 2 1 TMEM164 family ABC_tran_CTD PF16326.5 KPI88500.1 - 1 9.6 5.2 0.18 12.1 1.2 1.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain Whib PF02467.16 KPI88500.1 - 1.4 9.5 3.8 0.98 10.1 0.1 2.6 3 0 0 3 3 3 0 Transcription factor WhiB zf-RING_2 PF13639.6 KPI88501.1 - 3.7e-13 49.6 9.0 6.4e-13 48.8 9.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KPI88501.1 - 3.5e-07 29.8 2.8 8.6e-07 28.6 2.8 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KPI88501.1 - 8.9e-07 28.6 9.3 1.6e-06 27.9 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI88501.1 - 1.1e-06 28.5 6.8 2e-06 27.7 6.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KPI88501.1 - 4.7e-06 26.8 7.8 1.1e-05 25.6 7.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KPI88501.1 - 5.6e-06 26.1 6.3 9.8e-06 25.3 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KPI88501.1 - 0.00096 19.0 8.8 0.0018 18.1 8.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI88501.1 - 0.0015 18.4 8.0 0.0028 17.6 8.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KPI88501.1 - 0.0082 16.0 6.2 0.017 15.0 6.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KPI88501.1 - 0.012 15.6 2.8 0.025 14.6 2.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 KPI88501.1 - 0.029 14.6 8.4 0.55 10.4 8.4 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain DUF4776 PF16003.5 KPI88501.1 - 0.13 11.3 1.0 0.18 10.8 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Zn_ribbon_17 PF17120.5 KPI88501.1 - 0.18 11.4 6.5 0.35 10.5 6.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 KPI88501.1 - 0.21 11.4 7.6 0.37 10.6 7.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zinc_ribbon_16 PF17034.5 KPI88501.1 - 0.82 9.9 3.5 1.7 8.9 3.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon like family RINGv PF12906.7 KPI88501.1 - 3.1 8.0 7.9 6.4 7.0 7.9 1.5 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 KPI88501.1 - 5.5 7.4 8.4 10 6.5 8.4 1.4 1 0 0 1 1 1 0 RING-like domain MutS_V PF00488.21 KPI88502.1 - 4.8e-50 170.2 0.0 1.2e-49 168.9 0.0 1.7 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KPI88502.1 - 1.9e-22 80.4 0.5 3.1e-22 79.7 0.0 1.6 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 KPI88502.1 - 3.2e-19 69.2 0.0 5.9e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 KPI88502.1 - 0.00019 21.7 0.0 0.00037 20.8 0.0 1.4 1 0 0 1 1 1 1 MutS family domain IV tRNA-synt_1c PF00749.21 KPI88504.1 - 7.4e-104 347.0 0.0 9.8e-104 346.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KPI88504.1 - 4.9e-41 140.5 0.0 7.5e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain PCNA_N PF00705.18 KPI88505.1 - 2.4e-41 140.4 2.2 3.6e-41 139.8 1.4 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 KPI88505.1 - 1.6e-38 131.8 0.2 1.3e-19 70.7 0.1 2.4 2 0 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 KPI88505.1 - 4.6e-07 29.6 0.1 7.2e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 KPI88505.1 - 0.029 13.5 0.0 0.43 9.7 0.1 2.1 2 0 0 2 2 2 0 Hus1-like protein Diphthami_syn_2 PF01902.17 KPI88505.1 - 0.063 12.8 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Diphthamide synthase RFX_DNA_binding PF02257.15 KPI88505.1 - 0.16 12.6 0.0 27 5.5 0.0 2.2 2 0 0 2 2 2 0 RFX DNA-binding domain GHMP_kinases_N PF00288.26 KPI88506.1 - 4.2e-13 49.3 0.4 1.6e-12 47.5 0.4 2.1 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KPI88506.1 - 3.2e-05 24.2 0.4 0.0001 22.6 0.2 2.0 2 0 0 2 2 2 1 GHMP kinases C terminal Eno-Rase_NADH_b PF12242.8 KPI88506.1 - 0.16 11.8 0.3 0.83 9.5 0.1 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Gpr1_Fun34_YaaH PF01184.19 KPI88507.1 - 0.0023 17.6 0.1 0.003 17.2 0.1 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF1475 PF07343.11 KPI88507.1 - 0.006 16.4 0.1 0.007 16.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1475) Ribosomal_L7Ae PF01248.26 KPI88508.1 - 4.2e-25 87.3 0.1 4.9e-25 87.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 KPI88508.1 - 3.2e-05 23.7 0.0 4.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 KPI88508.1 - 0.0013 18.8 0.2 0.0014 18.7 0.2 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 GAF PF01590.26 KPI88509.1 - 2.1e-29 102.8 0.0 3.9e-14 53.4 0.0 3.1 3 0 0 3 3 3 2 GAF domain PDEase_I PF00233.19 KPI88509.1 - 1.6e-22 80.4 5.6 3.4e-22 79.3 5.6 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF_2 PF13185.6 KPI88509.1 - 5.8e-18 65.5 0.0 8.6e-08 32.6 0.0 3.1 3 0 0 3 3 3 2 GAF domain GAF_3 PF13492.6 KPI88509.1 - 3.8e-09 37.0 0.0 1.3e-05 25.6 0.0 3.0 3 0 0 3 3 3 2 GAF domain HMG_box_2 PF09011.10 KPI88510.1 - 0.0043 17.6 0.0 0.014 15.9 0.0 1.9 1 0 0 1 1 1 1 HMG-box domain Nup160 PF11715.8 KPI88511.1 - 0.057 12.0 0.1 0.095 11.3 0.1 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Sld5 PF05916.11 KPI88512.1 - 0.073 13.5 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 GINS complex protein Presenilin PF01080.17 KPI88513.1 - 1.5e-74 251.1 29.9 1e-53 182.6 17.2 2.0 1 1 1 2 2 2 2 Presenilin Radical_SAM PF04055.21 KPI88514.1 - 2.3e-15 57.3 0.0 4.8e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.12 KPI88514.1 - 3e-15 56.3 0.0 5.9e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Wyosine base formation Pkinase PF00069.25 KPI88516.1 - 5.6e-57 193.1 0.0 7.1e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88516.1 - 1.4e-25 90.1 0.0 6.4e-25 87.9 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.21 KPI88516.1 - 4.9e-13 49.0 4.4 1.1e-12 47.9 4.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger APH PF01636.23 KPI88516.1 - 0.00015 21.8 0.0 0.00025 21.1 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI88516.1 - 0.00032 19.6 0.0 0.00044 19.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FYVE_2 PF02318.16 KPI88516.1 - 0.0024 18.1 6.0 0.0066 16.7 6.0 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger Choline_kinase PF01633.20 KPI88516.1 - 0.047 13.3 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase zf-HYPF PF07503.12 KPI88516.1 - 0.11 12.3 0.2 0.11 12.3 0.2 2.7 3 0 0 3 3 3 0 HypF finger DZR PF12773.7 KPI88516.1 - 0.81 9.8 8.4 2.8 8.1 0.9 2.7 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_5 PF14634.6 KPI88516.1 - 1.6 8.8 11.9 1 9.4 9.6 2.0 2 0 0 2 2 2 0 zinc-RING finger domain zf-CCHC PF00098.23 KPI88516.1 - 2.5 8.3 6.3 1.7 8.8 1.3 2.5 2 0 0 2 2 2 0 Zinc knuckle Cnd1 PF12717.7 KPI88517.1 - 5.5e-23 81.8 3.1 3.9e-18 66.0 0.1 4.6 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KPI88517.1 - 2.3e-06 27.4 2.9 1.4 9.4 0.0 5.7 5 0 0 5 5 5 2 HEAT repeat Cnd3 PF12719.7 KPI88517.1 - 0.00012 21.3 2.7 0.0076 15.5 0.4 3.0 3 1 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 KPI88517.1 - 0.0006 20.2 4.0 5.2 7.5 0.1 5.2 4 2 1 5 5 5 1 HEAT repeats Cnd1_N PF12922.7 KPI88517.1 - 0.0011 18.9 0.0 0.0058 16.5 0.0 2.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term Adaptin_N PF01602.20 KPI88517.1 - 0.0029 16.2 3.8 0.063 11.8 0.1 3.4 3 1 0 3 3 3 1 Adaptin N terminal region HEAT_EZ PF13513.6 KPI88517.1 - 0.043 14.3 0.2 14 6.3 0.0 4.2 3 0 0 3 3 3 0 HEAT-like repeat V-ATPase_H_C PF11698.8 KPI88517.1 - 0.052 13.7 1.9 6 7.0 0.1 3.7 3 0 0 3 3 3 0 V-ATPase subunit H PfkB PF00294.24 KPI88518.1 - 3.7e-16 59.3 0.0 2.7e-15 56.5 0.0 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Tyr_Deacylase PF02580.16 KPI88520.1 - 1.6e-46 158.4 0.0 1.8e-46 158.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Acetyltransf_1 PF00583.25 KPI88522.1 - 2.9e-16 59.8 0.3 4.3e-16 59.2 0.3 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI88522.1 - 2.3e-06 27.9 0.0 3.3e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KPI88522.1 - 5.9e-05 23.0 0.0 7.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI88522.1 - 0.0016 18.4 0.0 0.0064 16.4 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_6 PF13480.7 KPI88522.1 - 0.0025 18.0 0.6 0.0054 16.9 0.6 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KPI88522.1 - 0.0051 16.9 0.1 0.0092 16.1 0.1 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 KPI88522.1 - 0.038 14.1 0.3 0.066 13.3 0.3 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3161 PF11362.8 KPI88522.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3161) MFS_1 PF07690.16 KPI88523.1 - 5e-14 52.0 36.6 2.6e-11 43.0 27.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 KPI88523.1 - 6.2e-14 52.1 11.6 6.2e-14 52.1 11.6 2.6 3 1 0 3 3 3 1 Nodulin-like Trp_oprn_chp PF09534.10 KPI88523.1 - 0.95 9.2 5.9 8 6.2 0.0 3.8 4 1 0 5 5 5 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Phasin_2 PF09361.10 KPI88525.1 - 0.035 14.4 0.9 6.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Phasin protein TP6A_N PF04406.14 KPI88527.1 - 3.1e-08 33.5 0.0 8.2e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Type IIB DNA topoisomerase NDK PF00334.19 KPI88528.1 - 0.0022 18.0 0.0 0.055 13.5 0.0 3.0 3 0 0 3 3 3 1 Nucleoside diphosphate kinase FtsX_ECD PF18075.1 KPI88528.1 - 0.27 11.9 1.0 0.9 10.2 0.2 2.3 2 0 0 2 2 2 0 FtsX extracellular domain HA2 PF04408.23 KPI88532.1 - 1.4e-17 64.0 0.0 1.4e-17 64.0 0.0 3.3 4 0 0 4 4 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KPI88532.1 - 3.1e-16 59.5 0.0 7.9e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KPI88532.1 - 4.4e-15 56.0 0.2 1.5e-14 54.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI88532.1 - 8.8e-09 35.4 0.2 1.1e-07 31.8 0.1 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI88532.1 - 2.5e-05 24.6 0.9 7.1e-05 23.1 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI88532.1 - 3.9e-05 23.5 1.5 6.6e-05 22.7 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KPI88532.1 - 0.0011 19.4 0.5 0.14 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain PDT PF00800.18 KPI88532.1 - 0.013 15.4 0.3 0.026 14.3 0.3 1.5 1 0 0 1 1 1 0 Prephenate dehydratase IstB_IS21 PF01695.17 KPI88532.1 - 0.052 13.3 0.1 7.7 6.2 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 KPI88532.1 - 0.058 12.9 0.0 0.18 11.3 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region Flavi_DEAD PF07652.14 KPI88532.1 - 0.08 12.9 0.1 0.26 11.3 0.1 1.9 2 0 0 2 2 2 0 Flavivirus DEAD domain SRP54 PF00448.22 KPI88532.1 - 0.13 11.9 1.5 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF3886 PF13025.6 KPI88532.1 - 0.63 10.3 0.0 0.63 10.3 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3886) ABC_tran PF00005.27 KPI88532.1 - 0.73 10.3 3.2 1.9 9.0 0.3 2.9 2 1 0 2 2 2 0 ABC transporter Phytochelatin PF05023.14 KPI88533.1 - 3.5e-06 26.4 0.1 0.064 12.5 0.0 4.4 5 0 0 5 5 5 3 Phytochelatin synthase KASH_CCD PF14662.6 KPI88534.1 - 0.00024 21.0 2.3 0.00027 20.8 2.3 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH OmpH PF03938.14 KPI88534.1 - 0.006 16.9 3.0 0.0067 16.8 3.0 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) DUF148 PF02520.17 KPI88534.1 - 0.0089 16.1 2.1 0.011 15.9 2.1 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF148 DUF4407 PF14362.6 KPI88534.1 - 0.02 14.3 1.4 0.019 14.3 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4686 PF15742.5 KPI88534.1 - 0.031 13.4 3.8 0.032 13.4 3.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) Cob_adeno_trans PF01923.18 KPI88534.1 - 0.043 13.9 0.2 0.044 13.9 0.2 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase TEX13 PF15186.6 KPI88534.1 - 0.058 13.1 3.7 0.07 12.8 3.7 1.1 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family CENP-H PF05837.12 KPI88534.1 - 0.058 13.8 2.9 0.087 13.2 2.9 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Ku_PK_bind PF08785.11 KPI88534.1 - 0.064 13.4 0.1 0.11 12.6 0.1 1.5 1 1 0 1 1 1 0 Ku C terminal domain like Herpes_UL25 PF01499.16 KPI88534.1 - 0.094 11.2 0.8 0.11 11.1 0.8 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family Spc7 PF08317.11 KPI88534.1 - 0.14 11.0 4.4 0.16 10.8 4.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein NPV_P10 PF05531.12 KPI88534.1 - 0.17 12.3 3.0 0.3 11.6 3.0 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FUSC PF04632.12 KPI88534.1 - 0.18 10.3 0.6 0.17 10.4 0.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4140 PF13600.6 KPI88534.1 - 0.19 12.1 5.8 0.28 11.6 5.8 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Hrs_helical PF12210.8 KPI88534.1 - 0.22 12.1 4.0 1.5 9.4 4.0 2.0 1 1 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate APG6_N PF17675.1 KPI88534.1 - 0.24 11.9 5.5 0.28 11.7 5.5 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc24 PF08286.11 KPI88534.1 - 0.28 11.4 3.2 0.32 11.3 2.6 1.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 SlyX PF04102.12 KPI88534.1 - 0.72 10.5 7.1 1.3 9.7 1.3 2.1 1 1 1 2 2 2 0 SlyX Ribosomal_S24e PF01282.19 KPI88536.1 - 3.9e-28 97.2 0.0 7.6e-28 96.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e ASH PF15780.5 KPI88537.1 - 9.3e-26 89.9 4.9 2.3e-05 24.5 0.0 10.2 10 2 1 11 11 11 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 KPI88537.1 - 1e-10 41.4 0.0 0.058 13.2 0.0 8.2 9 0 0 9 9 9 2 MSP (Major sperm protein) domain fn3_5 PF06280.12 KPI88537.1 - 0.00043 21.0 0.1 1.9 9.2 0.0 5.1 6 0 0 6 6 6 1 Fn3-like domain ABC2_membrane PF01061.24 KPI88538.1 - 1.3e-38 132.5 23.2 1.3e-38 132.5 23.2 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KPI88538.1 - 1.1e-24 87.5 0.0 1.8e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KPI88538.1 - 3.1e-08 33.8 0.0 0.0041 17.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KPI88538.1 - 0.00018 20.7 26.3 0.00037 19.7 26.2 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 KPI88538.1 - 0.00034 20.6 0.0 0.00072 19.5 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KPI88538.1 - 0.00095 19.6 0.0 0.0019 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KPI88538.1 - 0.0012 18.6 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KPI88538.1 - 0.0022 18.3 0.0 0.0066 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI88538.1 - 0.008 16.7 0.0 0.013 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain TMEM95 PF15203.6 KPI88538.1 - 0.014 15.1 0.1 0.026 14.2 0.1 1.4 1 0 0 1 1 1 0 TMEM95 family SMC_N PF02463.19 KPI88538.1 - 0.014 14.8 0.0 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KPI88538.1 - 0.014 15.9 0.0 0.026 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KPI88538.1 - 0.016 15.5 0.2 0.041 14.1 0.1 1.8 2 0 0 2 2 1 0 AAA domain IstB_IS21 PF01695.17 KPI88538.1 - 0.041 13.6 0.1 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 KPI88538.1 - 0.048 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KPI88538.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 KPI88538.1 - 0.15 12.2 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KPI88538.1 - 0.2 10.7 0.1 0.34 9.9 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 KPI88538.1 - 0.22 11.2 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 KPI88539.1 - 0.056 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_16 PF13191.6 KPI88539.1 - 0.079 13.3 0.6 0.32 11.4 0.6 2.2 1 1 0 1 1 1 0 AAA ATPase domain CCDC24 PF15669.5 KPI88539.1 - 0.92 9.3 5.3 2.2 8.1 5.3 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family SDP_N PF12278.8 KPI88539.1 - 5 7.3 5.2 9.7 6.3 5.2 1.4 1 0 0 1 1 1 0 Sex determination protein N terminal Peptidase_M29 PF02073.15 KPI88540.1 - 0.016 14.0 0.3 0.018 13.8 0.3 1.0 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) ChaB PF06150.12 KPI88540.1 - 0.073 13.7 0.6 0.14 12.7 0.1 1.7 1 1 1 2 2 2 0 ChaB VHS PF00790.19 KPI88541.1 - 0.045 13.6 0.0 0.089 12.6 0.0 1.5 1 0 0 1 1 1 0 VHS domain PHF5 PF03660.14 KPI88542.1 - 3e-33 114.1 10.2 3.5e-33 113.9 10.2 1.0 1 0 0 1 1 1 1 PHF5-like protein FYVE_2 PF02318.16 KPI88542.1 - 0.22 11.8 6.7 0.4 10.9 6.7 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger DZR PF12773.7 KPI88542.1 - 0.51 10.4 11.4 0.59 10.2 8.2 2.4 1 1 2 3 3 3 0 Double zinc ribbon zf-CHY PF05495.12 KPI88542.1 - 0.6 10.6 10.5 0.78 10.3 8.6 1.9 1 1 1 2 2 2 0 CHY zinc finger TF_Zn_Ribbon PF08271.12 KPI88542.1 - 0.7 9.4 12.0 0.32 10.6 2.0 2.5 2 1 0 2 2 2 0 TFIIB zinc-binding zf-C3HC4_3 PF13920.6 KPI88542.1 - 4.6 7.2 15.1 0.095 12.6 4.6 2.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI88543.1 - 2.2e-12 47.1 3.8 2.2e-12 47.1 3.8 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 KPI88543.1 - 3.3e-09 36.3 0.6 1e-08 34.7 0.6 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KPI88543.1 - 2.5e-08 33.6 2.9 2.5e-08 33.6 2.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KPI88543.1 - 4.8e-07 29.5 1.8 4.8e-07 29.5 1.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI88543.1 - 9.2e-07 28.8 1.3 2.1e-06 27.7 1.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KPI88543.1 - 1e-06 28.9 6.4 1.3e-05 25.4 6.4 2.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KPI88543.1 - 1.1e-06 28.4 1.7 1.1e-06 28.4 1.7 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI88543.1 - 6.2e-06 26.1 2.3 1.6e-05 24.8 2.3 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KPI88543.1 - 0.00028 20.7 1.5 0.00093 19.0 1.4 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KPI88543.1 - 0.017 14.8 2.6 0.017 14.8 2.6 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 KPI88543.1 - 0.12 12.4 2.9 0.55 10.3 2.9 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 KPI88543.1 - 0.13 12.4 3.4 1.1 9.5 3.4 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 KPI88543.1 - 0.16 11.8 1.4 0.54 10.1 1.6 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ATP-grasp_2 PF08442.10 KPI88544.1 - 5.4e-62 209.0 3.6 9.6e-62 208.1 3.6 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 KPI88544.1 - 1.9e-23 83.0 1.9 2.1e-23 82.8 0.4 1.9 2 0 0 2 2 2 1 CoA-ligase Vma12 PF11712.8 KPI88546.1 - 0.019 15.0 3.0 0.019 15.0 3.0 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase ABC_export PF16962.5 KPI88546.1 - 0.022 13.2 6.5 0.031 12.7 6.5 1.2 1 0 0 1 1 1 0 Putative ABC exporter BRI3BP PF14965.6 KPI88546.1 - 0.028 13.9 3.0 0.036 13.6 3.0 1.1 1 0 0 1 1 1 0 Negative regulator of p53/TP53 DUF1218 PF06749.12 KPI88546.1 - 0.1 13.1 0.3 0.1 13.1 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) DUF2207 PF09972.9 KPI88546.1 - 0.21 10.3 2.3 0.29 9.8 2.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FGFR3_TM PF18123.1 KPI88546.1 - 5.8 6.5 10.9 3.9 7.1 1.1 2.8 2 0 0 2 2 2 0 Fibroblast growth factor receptor 3 transmembrane domain Glyco_hydro_32C PF08244.12 KPI88547.1 - 1.4e-05 25.1 0.0 1.6e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Glyco_hydro_32N PF00251.20 KPI88548.1 - 0.0025 17.4 0.0 0.0031 17.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Bromodomain PF00439.25 KPI88549.1 - 1.3e-22 79.7 0.0 2e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 Bromodomain DUF1635 PF07795.11 KPI88549.1 - 0.33 10.8 8.4 0.54 10.1 8.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Secretin_N_2 PF07655.13 KPI88549.1 - 1.2 9.7 10.6 5.4 7.6 9.7 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain AF-4 PF05110.13 KPI88549.1 - 2.1 6.3 18.3 3.2 5.7 18.3 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BUD22 PF09073.10 KPI88549.1 - 3.2 7.0 21.1 3.8 6.7 21.1 1.2 1 0 0 1 1 1 0 BUD22 GTP1_OBG PF01018.22 KPI88550.1 - 1.5e-38 131.8 5.3 2.2e-38 131.3 5.3 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 KPI88550.1 - 1.7e-18 66.7 0.0 2.8e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI88550.1 - 3e-06 26.8 0.0 2.6e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 KPI88550.1 - 0.0085 15.6 0.0 0.094 12.2 0.0 2.2 2 1 0 2 2 2 1 ADP-ribosylation factor family DSHCT PF08148.12 KPI88551.1 - 1.3e-44 151.8 2.8 2.1e-44 151.1 0.3 2.6 3 0 0 3 3 3 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 KPI88551.1 - 1.3e-44 153.2 0.5 7e-44 150.8 0.2 2.0 2 0 0 2 2 2 1 rRNA-processing arch domain DEAD PF00270.29 KPI88551.1 - 4.2e-22 78.7 0.7 4.3e-21 75.5 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88551.1 - 3.9e-07 30.4 0.0 2e-06 28.1 0.0 2.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88551.1 - 6.1e-07 29.6 0.1 1.8e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 KPI88551.1 - 0.011 15.7 1.0 0.036 14.0 0.0 2.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 KPI88551.1 - 0.012 15.8 0.0 0.075 13.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain FlxA PF14282.6 KPI88551.1 - 0.013 15.5 7.6 0.03 14.3 7.6 1.5 1 0 0 1 1 1 0 FlxA-like protein Helicase_RecD PF05127.14 KPI88551.1 - 0.022 14.6 1.0 3.3 7.5 0.0 2.8 2 0 0 2 2 2 0 Helicase PhoH PF02562.16 KPI88551.1 - 0.03 13.8 0.0 0.065 12.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 KPI88551.1 - 0.045 12.8 0.0 0.11 11.5 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein MutS_III PF05192.18 KPI88551.1 - 0.053 13.7 0.5 5.2 7.2 0.0 3.1 2 2 0 3 3 3 0 MutS domain III Zot PF05707.12 KPI88551.1 - 0.16 11.6 0.0 0.44 10.2 0.0 1.7 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_16 PF13191.6 KPI88551.1 - 0.17 12.3 0.4 1.8 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain DUF3856 PF12968.7 KPI88551.1 - 0.32 11.1 1.8 12 6.0 0.1 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF3856) CobA_CobO_BtuR PF02572.15 KPI88551.1 - 0.68 10.2 3.7 0.84 9.9 0.0 2.9 4 0 0 4 4 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Syntaxin_2 PF14523.6 KPI88551.1 - 0.9 9.9 4.8 1.4 9.4 1.0 3.1 4 0 0 4 4 3 0 Syntaxin-like protein Cytochrom_B562 PF07361.11 KPI88551.1 - 6 7.6 7.5 23 5.7 0.2 3.2 2 0 0 2 2 2 0 Cytochrome b562 GSHPx PF00255.19 KPI88552.1 - 1.8e-26 91.8 0.0 2.3e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KPI88552.1 - 0.019 14.9 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 KPI88552.1 - 0.068 12.9 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Redoxin RNase_PH PF01138.21 KPI88553.1 - 1.5e-30 106.3 0.4 2.3e-30 105.8 0.4 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KPI88553.1 - 0.00035 20.5 0.0 0.0007 19.6 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF1623 PF07785.11 KPI88553.1 - 0.024 14.8 1.0 0.046 13.9 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) DUF2299 PF10061.9 KPI88553.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2299) Swi5 PF07061.11 KPI88554.1 - 4.8e-08 33.0 0.1 6.7e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 Swi5 HTH_DeoR PF08220.12 KPI88554.1 - 0.069 12.9 0.1 0.19 11.5 0.0 1.7 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain DNA_ligase_A_N PF04675.14 KPI88554.1 - 0.091 13.1 0.0 0.1 12.9 0.0 1.1 1 0 0 1 1 1 0 DNA ligase N terminus Adap_comp_sub PF00928.21 KPI88555.1 - 4.8e-54 183.5 0.0 5.8e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KPI88555.1 - 1.7e-06 28.0 1.0 2.6e-06 27.4 1.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RRM_1 PF00076.22 KPI88556.1 - 2e-07 30.7 0.0 3.1e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI88556.1 - 1e-05 25.1 0.0 1.1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cullin PF00888.22 KPI88558.1 - 5.7e-55 187.1 0.2 7.2e-55 186.7 0.2 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KPI88558.1 - 2e-13 50.2 0.0 5e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain Stork_head PF10264.9 KPI88558.1 - 0.044 14.0 0.0 0.19 11.9 0.0 2.1 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain Fibrillarin PF01269.17 KPI88559.1 - 1.5e-102 341.5 0.0 1.8e-102 341.3 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 KPI88559.1 - 0.001 18.8 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 KPI88559.1 - 0.053 13.3 0.1 0.096 12.4 0.1 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Thioredoxin PF00085.20 KPI88561.1 - 0.15 12.0 0.0 0.71 9.9 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin Collagen PF01391.18 KPI88561.1 - 3.7 7.4 7.7 7.2 6.5 7.7 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) vATP-synt_E PF01991.18 KPI88563.1 - 9.2e-40 136.2 8.4 1e-39 136.0 8.4 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit FliG_M PF14841.6 KPI88563.1 - 0.01 16.0 2.8 0.031 14.5 0.3 2.7 2 1 1 3 3 3 0 FliG middle domain Flot PF15975.5 KPI88563.1 - 1.4 9.1 10.2 3.4 7.9 10.2 1.7 1 1 0 1 1 1 0 Flotillin NAM-associated PF14303.6 KPI88563.1 - 2.4 8.9 11.6 3.6 8.3 11.6 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain WD40 PF00400.32 KPI88565.1 - 2.4e-06 28.1 7.7 0.2 12.6 0.3 5.9 6 0 0 6 6 6 2 WD domain, G-beta repeat ALG3 PF05208.13 KPI88566.1 - 2.3e-118 395.7 13.7 2.6e-118 395.5 13.7 1.0 1 0 0 1 1 1 1 ALG3 protein Metallophos PF00149.28 KPI88567.1 - 9e-13 49.2 0.0 3.7e-09 37.4 0.0 3.2 2 2 0 2 2 2 2 Calcineurin-like phosphoesterase DUF72 PF01904.18 KPI88568.1 - 5.1e-31 108.5 0.8 4.5e-28 98.8 0.5 2.1 2 0 0 2 2 2 2 Protein of unknown function DUF72 TPR_2 PF07719.17 KPI88569.1 - 1.5e-09 37.2 5.4 0.002 18.1 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI88569.1 - 1.2e-08 34.4 3.7 0.0045 16.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI88569.1 - 5.6e-06 25.9 0.1 0.07 12.8 0.0 3.2 2 1 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 KPI88569.1 - 0.00021 21.5 1.9 0.2 12.0 0.3 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI88569.1 - 0.0011 18.8 4.9 0.3 11.2 0.1 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI88569.1 - 0.011 16.5 1.5 0.31 12.0 0.6 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI88569.1 - 0.012 15.8 0.5 0.44 10.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Ctf8 PF09696.10 KPI88569.1 - 0.063 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Ctf8 RsdA_SigD_bd PF16751.5 KPI88569.1 - 0.93 9.8 3.9 0.48 10.7 1.2 1.9 2 0 0 2 2 2 0 Anti-sigma-D factor RsdA to sigma factor binding region Draxin PF15550.6 KPI88569.1 - 1.7 8.5 3.8 16 5.3 0.1 2.1 2 0 0 2 2 2 0 Draxin SPA PF08616.10 KPI88571.1 - 0.00078 19.4 0.0 0.0019 18.1 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 KPI88571.1 - 0.003 16.3 0.0 0.0054 15.5 0.0 1.4 1 0 0 1 1 1 1 Transport protein Avl9 Acetyltransf_10 PF13673.7 KPI88572.1 - 0.015 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI88572.1 - 0.032 14.5 0.0 0.091 13.0 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family DnaJ PF00226.31 KPI88573.1 - 1.1e-22 79.9 0.3 1.7e-22 79.3 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain DEAD PF00270.29 KPI88577.1 - 9.2e-49 165.6 0.0 2.3e-48 164.3 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88577.1 - 4.6e-32 110.7 0.0 2.8e-30 104.9 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88577.1 - 4.7e-06 26.7 0.0 0.00063 19.8 0.0 2.2 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KPI88577.1 - 0.00044 20.0 0.0 0.11 12.2 0.0 2.5 2 1 0 2 2 2 2 AAA domain ERCC3_RAD25_C PF16203.5 KPI88577.1 - 0.0008 18.7 0.1 0.0012 18.1 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase PRAI PF00697.22 KPI88577.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase EMP24_GP25L PF01105.24 KPI88579.1 - 2.9e-22 79.5 0.0 3.9e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CrgA PF06781.12 KPI88579.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Cell division protein CrgA Mucin PF01456.17 KPI88579.1 - 0.26 11.3 2.0 0.88 9.6 0.2 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein Dynein_light PF01221.18 KPI88580.1 - 4.9e-20 71.6 0.0 5.9e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF3646 PF12362.8 KPI88580.1 - 0.0024 18.2 0.0 0.0044 17.3 0.0 1.3 1 1 0 1 1 1 1 DNA polymerase III gamma and tau subunits C terminal Methyltr_RsmB-F PF01189.17 KPI88581.1 - 5e-29 101.4 0.0 1.1e-21 77.5 0.0 3.0 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KPI88581.1 - 0.012 15.7 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 FtsJ-like methyltransferase Y_phosphatase PF00102.27 KPI88582.1 - 2.3e-40 138.7 0.0 9.3e-40 136.7 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 KPI88582.1 - 2.2e-07 30.8 0.1 2.1e-06 27.6 0.1 2.6 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KPI88582.1 - 0.12 12.3 0.2 0.41 10.6 0.2 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family DUF4746 PF15928.5 KPI88583.1 - 9.3 5.6 6.8 1.2 8.5 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Choline_transpo PF04515.12 KPI88585.1 - 1e-65 222.1 28.0 1e-65 222.1 28.0 2.8 2 1 0 2 2 2 1 Plasma-membrane choline transporter DPM3 PF08285.11 KPI88585.1 - 0.36 11.0 0.0 0.36 11.0 0.0 5.1 5 2 1 6 6 6 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) BRCT_2 PF16589.5 KPI88586.1 - 5.8e-05 23.4 0.0 0.044 14.2 0.0 2.8 2 2 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 KPI88586.1 - 7.9e-05 22.7 0.0 0.079 13.0 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 KPI88586.1 - 9.3e-05 22.7 0.0 0.0049 17.2 0.0 3.1 3 1 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KPI88586.1 - 0.0047 16.8 0.1 1.2 9.2 0.0 2.5 2 0 0 2 2 2 2 twin BRCT domain Colicin_Ia PF11504.8 KPI88586.1 - 0.15 12.2 0.3 0.38 10.9 0.0 1.8 2 0 0 2 2 2 0 Colicin Ia Sec1 PF00995.23 KPI88587.1 - 6.7e-100 336.0 0.0 8e-100 335.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family GCP_N_terminal PF17681.1 KPI88588.1 - 2.3e-16 60.3 0.0 1.6e-14 54.2 0.0 2.6 1 1 0 2 2 2 2 Gamma tubulin complex component N-terminal MMR_HSR1_Xtn PF16897.5 KPI88589.1 - 9.9e-42 141.3 0.1 2.1e-41 140.2 0.0 1.6 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 KPI88589.1 - 2.3e-19 69.6 0.0 4.7e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 KPI88589.1 - 5e-17 61.7 0.0 9.8e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 KPI88589.1 - 3.1e-09 36.5 0.0 1e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 KPI88589.1 - 0.0046 16.0 0.2 0.011 14.8 0.1 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 KPI88589.1 - 0.14 12.2 0.1 2.4 8.2 0.0 2.2 1 1 1 2 2 2 0 Dynamin family Guanylate_kin PF00625.21 KPI88590.1 - 6.4e-38 130.2 0.1 6e-26 91.2 0.0 3.0 2 1 0 2 2 2 2 Guanylate kinase AAA_33 PF13671.6 KPI88590.1 - 6.6e-05 23.1 0.9 0.0022 18.2 0.9 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 KPI88590.1 - 0.00055 19.9 0.0 0.00087 19.3 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 KPI88590.1 - 0.00065 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KPI88590.1 - 0.00069 20.0 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KPI88590.1 - 0.0022 18.1 0.0 0.014 15.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KPI88590.1 - 0.0026 18.3 0.1 0.0071 16.9 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA PF00004.29 KPI88590.1 - 0.0039 17.6 0.0 0.0085 16.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KPI88590.1 - 0.0052 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region NB-ARC PF00931.22 KPI88590.1 - 0.0054 16.0 0.0 0.016 14.4 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain RNA_helicase PF00910.22 KPI88590.1 - 0.0068 16.8 0.0 0.075 13.4 0.0 2.5 3 0 0 3 3 2 1 RNA helicase AAA_29 PF13555.6 KPI88590.1 - 0.009 15.7 0.3 0.018 14.7 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 KPI88590.1 - 0.044 13.5 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 KPI88590.1 - 0.067 13.7 0.0 0.098 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KPI88590.1 - 0.074 13.0 0.0 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Glyco_hydro_63 PF03200.16 KPI88590.1 - 0.082 11.7 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain G-alpha PF00503.20 KPI88590.1 - 0.11 11.6 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit NACHT PF05729.12 KPI88590.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 KPI88590.1 - 0.15 11.8 0.0 0.15 11.8 0.0 1.9 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 KPI88590.1 - 0.16 12.6 0.1 5.2 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KPI88590.1 - 0.16 12.4 0.1 4.9 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 KPI88591.1 - 1.9e-39 131.9 0.1 5.1e-05 22.9 0.0 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 KPI88591.1 - 1.5e-35 118.4 1.9 0.00026 20.9 0.0 9.7 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 KPI88591.1 - 2.9e-32 108.1 0.3 0.00038 20.4 0.0 8.7 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_16 PF13432.6 KPI88591.1 - 4.9e-26 91.1 0.2 0.0028 18.2 0.0 6.7 4 2 2 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 KPI88591.1 - 1.4e-25 88.7 0.0 0.00083 19.0 0.0 8.5 3 2 5 8 8 8 6 TPR repeat TPR_12 PF13424.6 KPI88591.1 - 1.3e-22 79.9 14.5 1.6e-06 28.3 0.3 7.0 5 3 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 KPI88591.1 - 1.7e-22 78.2 1.3 0.0007 20.2 0.0 8.5 4 3 5 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 KPI88591.1 - 1.6e-21 75.0 5.2 0.0014 18.9 0.0 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI88591.1 - 7.8e-20 71.2 2.2 0.0015 19.0 0.1 6.4 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 KPI88591.1 - 5.4e-16 58.1 9.9 0.83 10.4 0.0 8.7 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI88591.1 - 7.8e-14 51.6 0.5 0.0024 18.0 0.0 5.9 3 3 3 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI88591.1 - 3.8e-10 39.1 7.3 1.8 8.8 0.1 7.9 7 1 1 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI88591.1 - 2.7e-09 37.1 9.6 0.0088 16.2 0.0 5.3 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KPI88591.1 - 3.3e-08 33.1 14.8 0.00047 19.9 0.1 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_20 PF14561.6 KPI88591.1 - 6.3e-07 29.6 0.2 1.7 9.0 0.0 4.1 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 KPI88591.1 - 1.7e-05 24.2 2.5 1.8 7.7 0.0 4.4 2 1 1 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 KPI88591.1 - 0.00022 20.3 0.0 1.8 7.4 0.0 3.2 2 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 KPI88591.1 - 0.00028 21.2 5.5 0.1 13.3 0.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat Paf67 PF10255.9 KPI88591.1 - 0.00065 18.8 1.1 0.0048 16.0 0.1 2.4 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 DUF3808 PF10300.9 KPI88591.1 - 0.0012 17.6 1.0 0.0017 17.1 0.1 1.7 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) ChAPs PF09295.10 KPI88591.1 - 0.0023 17.0 0.8 0.13 11.3 0.1 2.7 2 1 2 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) GM_CSF PF01109.17 KPI88591.1 - 0.01 16.0 0.0 3.5 7.8 0.0 2.4 2 0 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor PknG_TPR PF16918.5 KPI88591.1 - 0.013 14.3 1.1 0.08 11.7 0.2 2.7 3 1 0 3 3 3 0 Protein kinase G tetratricopeptide repeat ANAPC5 PF12862.7 KPI88591.1 - 0.79 9.8 5.0 16 5.7 0.2 3.8 3 2 0 4 4 3 0 Anaphase-promoting complex subunit 5 Ribosomal_S18 PF01084.20 KPI88593.1 - 0.00027 21.1 0.0 0.00059 20.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 Glucokinase PF02685.16 KPI88594.1 - 2.6e-16 59.5 0.0 1e-15 57.5 0.0 1.8 1 1 0 1 1 1 1 Glucokinase Endonuclease_5 PF04493.14 KPI88595.1 - 7.5e-52 175.9 0.0 1.1e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease V adh_short PF00106.25 KPI88596.1 - 8.3e-22 77.6 0.0 3.8e-20 72.2 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KPI88596.1 - 1.5e-10 41.1 0.0 4.7e-09 36.2 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI88596.1 - 1.4e-07 31.6 0.0 2.6e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI88596.1 - 0.073 12.5 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 KPI88596.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 KPI88596.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Aminotran_1_2 PF00155.21 KPI88597.1 - 2.8e-64 217.6 0.0 3.2e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KPI88597.1 - 1.2e-07 31.4 0.0 3e-07 30.1 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KPI88597.1 - 2.1e-05 23.2 0.0 3.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KPI88597.1 - 0.00014 21.0 0.0 0.00024 20.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_3 PF00202.21 KPI88597.1 - 0.00075 18.3 0.0 0.0013 17.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KPI88597.1 - 0.0023 17.3 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Gp_dh_C PF02800.20 KPI88598.1 - 6.4e-69 230.6 0.0 8.8e-69 230.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KPI88598.1 - 6.1e-41 138.9 0.2 1.3e-40 137.8 0.2 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 KPI88598.1 - 9.4e-05 22.5 2.0 0.00047 20.3 0.9 2.5 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 KPI88598.1 - 0.016 15.2 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Ribonuc_red_sm PF00268.21 KPI88599.1 - 0.0056 16.2 0.1 0.095 12.1 0.1 2.2 2 0 0 2 2 2 1 Ribonucleotide reductase, small chain NdhS PF11623.8 KPI88599.1 - 0.061 13.0 0.2 18 5.1 0.0 3.4 4 0 0 4 4 4 0 NAD(P)H dehydrogenase subunit S MT PF12777.7 KPI88600.1 - 0.00073 18.7 0.1 0.0012 17.9 0.1 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor LMBR1 PF04791.16 KPI88600.1 - 0.0027 16.7 0.1 0.0027 16.7 0.1 1.8 2 0 0 2 2 2 1 LMBR1-like membrane protein DUF812 PF05667.11 KPI88600.1 - 0.0093 14.9 5.1 0.019 13.9 5.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Mitoc_mL59 PF18126.1 KPI88600.1 - 0.1 12.9 2.9 5.7 7.3 0.1 3.3 4 0 0 4 4 4 0 Mitochondrial ribosomal protein mL59 Antimicrobial17 PF08129.11 KPI88600.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta enterocin family HAUS6_N PF14661.6 KPI88600.1 - 0.15 11.6 5.3 0.41 10.2 0.7 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus 23S_rRNA_IVP PF05635.11 KPI88600.1 - 0.27 11.6 4.7 0.34 11.2 0.2 2.9 3 0 0 3 3 2 0 23S rRNA-intervening sequence protein DUF1043 PF06295.12 KPI88600.1 - 0.28 11.2 4.2 1.9 8.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Spc7 PF08317.11 KPI88600.1 - 0.75 8.6 15.0 2.2 7.1 1.1 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein MscS_porin PF12795.7 KPI88600.1 - 1 8.9 13.4 3.1 7.3 4.0 2.5 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain SKA2 PF16740.5 KPI88600.1 - 2 8.3 8.8 0.35 10.7 0.6 2.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF3450 PF11932.8 KPI88600.1 - 4.1 6.6 18.5 6.8 5.9 6.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) 4HBT_2 PF13279.6 KPI88601.1 - 1e-08 35.7 0.0 2.2e-08 34.6 0.0 1.4 1 1 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 KPI88601.1 - 1.5e-07 31.7 0.0 7.5e-06 26.2 0.0 2.6 2 0 0 2 2 2 1 Thioesterase superfamily LRR_4 PF12799.7 KPI88603.1 - 7.4e-16 58.0 0.3 0.05 14.0 0.0 6.1 4 2 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88603.1 - 5.5e-12 45.3 0.0 0.034 13.9 0.0 5.3 5 0 0 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 KPI88603.1 - 1.1e-07 31.4 0.3 27 5.8 0.0 7.3 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 KPI88603.1 - 3.9e-05 23.4 2.6 5.5 7.3 0.0 5.9 5 0 0 5 5 5 1 Leucine Rich repeat DUF3079 PF11278.8 KPI88603.1 - 2.2 8.2 6.5 8.9 6.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) TRAM_LAG1_CLN8 PF03798.16 KPI88604.1 - 4.9e-17 62.3 17.9 8e-17 61.6 17.9 1.3 1 0 0 1 1 1 1 TLC domain HEAT_2 PF13646.6 KPI88605.1 - 7.1e-28 96.8 10.3 1.3e-15 57.5 0.1 3.5 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 KPI88605.1 - 1.9e-17 62.1 9.1 0.0012 19.3 0.1 6.3 7 0 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT PF02985.22 KPI88605.1 - 4.2e-09 35.9 2.6 0.0017 18.4 0.0 5.5 6 1 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 KPI88605.1 - 3.5e-05 24.2 3.3 0.034 14.6 0.5 4.7 5 1 0 5 5 5 1 HEAT-like repeat Vitellogenin_N PF01347.22 KPI88605.1 - 0.015 13.8 0.1 0.29 9.5 0.1 2.2 2 1 0 2 2 2 0 Lipoprotein amino terminal region Peptidase_S78 PF04586.17 KPI88605.1 - 0.066 13.4 0.0 0.95 9.6 0.0 2.4 3 0 0 3 3 3 0 Caudovirus prohead serine protease DUF5463 PF17551.2 KPI88605.1 - 0.16 11.9 0.2 0.32 10.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5463) Sedlin_N PF04628.13 KPI88607.1 - 0.0001 22.4 0.0 0.00045 20.3 0.0 1.9 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region DUF4460 PF14687.6 KPI88608.1 - 7.1e-07 29.3 0.0 1.6e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF4461 PF14688.6 KPI88608.1 - 0.0017 18.2 0.3 0.092 12.5 0.4 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF4461) DUF2959 PF11172.8 KPI88608.1 - 2.2 8.4 5.2 22 5.1 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2959) LRR_6 PF13516.6 KPI88609.1 - 3.4e-06 26.7 4.5 0.24 11.5 0.1 4.5 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KPI88609.1 - 3.2e-05 24.2 0.2 0.037 14.5 0.0 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI88609.1 - 0.031 14.8 1.6 18 6.4 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_8 PF13855.6 KPI88609.1 - 0.036 13.8 1.4 6.3 6.6 0.1 3.9 5 0 0 5 5 5 0 Leucine rich repeat ELMO_CED12 PF04727.13 KPI88611.1 - 3.9e-40 137.8 0.1 5.2e-40 137.4 0.1 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3038 PF11237.8 KPI88611.1 - 0.013 15.6 1.0 0.046 13.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3038) Methyltransf_31 PF13847.6 KPI88612.1 - 0.036 13.9 0.2 0.07 12.9 0.2 1.4 1 0 0 1 1 1 0 Methyltransferase domain DNA_pol_E_B PF04042.16 KPI88612.1 - 0.057 12.8 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B DUF789 PF05623.12 KPI88614.1 - 1.4e-09 38.1 0.0 5e-08 33.0 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF789) EB1 PF03271.17 KPI88615.1 - 2e-05 24.7 0.1 4.6e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif zf-C2H2_4 PF13894.6 KPI88616.1 - 4.2e-11 42.7 21.8 0.0006 20.4 0.1 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI88616.1 - 5.4e-10 39.2 24.6 0.006 17.0 0.1 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KPI88616.1 - 1.6e-08 34.6 0.7 1.6e-08 34.6 0.7 6.1 6 0 0 6 6 6 1 Zinc-finger double domain zf-Di19 PF05605.12 KPI88616.1 - 7.4e-07 29.4 7.9 0.008 16.4 0.2 4.0 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 KPI88616.1 - 0.019 15.2 6.0 7.1 7.0 0.1 4.9 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 KPI88616.1 - 0.031 14.9 2.5 13 6.5 0.0 3.6 3 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 KPI88616.1 - 0.054 13.8 8.4 1.8 8.9 0.4 3.9 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-HYPF PF07503.12 KPI88616.1 - 0.84 9.5 10.7 3.3 7.6 1.6 4.2 4 0 0 4 4 4 0 HypF finger Ima1_N PF09779.9 KPI88616.1 - 2 9.3 10.3 2 9.3 0.1 3.8 3 1 0 3 3 3 0 Ima1 N-terminal domain zf-BED PF02892.15 KPI88616.1 - 3.1 7.9 13.3 2.2 8.3 0.9 3.7 3 1 0 4 4 4 0 BED zinc finger zf-H2C2_5 PF13909.6 KPI88616.1 - 4.7 7.1 33.6 0.19 11.5 1.3 6.1 6 1 0 6 6 6 0 C2H2-type zinc-finger domain Ogr_Delta PF04606.12 KPI88616.1 - 8.3 6.5 8.0 3.2 7.8 0.1 3.2 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zf-C2H2_11 PF16622.5 KPI88616.1 - 9.9 6.0 11.7 8.4 6.2 0.0 4.0 4 0 0 4 4 4 0 zinc-finger C2H2-type DNA_binding_1 PF01035.20 KPI88617.1 - 7.4e-21 74.1 0.0 1.8e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain HEAT PF02985.22 KPI88618.1 - 0.021 15.0 0.7 8 7.0 0.0 4.6 3 0 0 3 3 3 0 HEAT repeat Adaptin_N PF01602.20 KPI88618.1 - 0.056 12.0 0.0 0.17 10.4 0.0 1.7 1 0 0 1 1 1 0 Adaptin N terminal region Cnd1 PF12717.7 KPI88618.1 - 0.08 13.0 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 NuA4 PF09340.10 KPI88619.1 - 2.6e-08 33.6 0.0 8.4e-07 28.8 0.0 2.5 1 1 0 1 1 1 1 Histone acetyltransferase subunit NuA4 ADP_ribosyl_GH PF03747.14 KPI88620.1 - 8e-57 193.2 1.1 9.5e-57 192.9 1.1 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Bacteriocin_IIc PF10439.9 KPI88620.1 - 0.011 15.8 5.7 0.013 15.6 0.8 2.4 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_YMGG PF13441.6 KPI88620.1 - 0.023 14.5 4.2 0.85 9.4 0.1 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 KPI88620.1 - 0.059 13.4 5.7 0.53 10.3 0.0 2.4 2 0 0 2 2 2 0 Glycine zipper Rick_17kDa_Anti PF05433.15 KPI88620.1 - 0.35 10.8 10.1 2.4 8.1 1.1 2.4 2 0 0 2 2 2 0 Glycine zipper 2TM domain Transgly_assoc PF04226.13 KPI88620.1 - 0.71 10.2 3.4 0.37 11.1 0.5 1.9 2 0 0 2 2 2 0 Transglycosylase associated protein CRF PF00473.17 KPI88621.1 - 0.17 12.0 0.1 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 Corticotropin-releasing factor family BRCA2 PF00634.18 KPI88622.1 - 0.084 12.6 0.0 0.86 9.3 0.0 2.4 2 0 0 2 2 2 0 BRCA2 repeat DUF5051 PF16473.5 KPI88625.1 - 0.022 14.7 0.0 0.054 13.5 0.0 1.6 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like DBD_Tnp_Hermes PF10683.9 KPI88625.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain Ank_2 PF12796.7 KPI88626.1 - 3e-08 34.2 0.0 0.00043 20.8 0.0 3.7 2 2 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI88626.1 - 0.0002 21.5 1.7 19 6.2 0.2 5.2 6 0 0 6 6 6 1 Ankyrin repeat Ank_4 PF13637.6 KPI88626.1 - 0.01 16.4 6.1 3.7 8.3 0.3 4.5 4 1 1 5 5 5 0 Ankyrin repeats (many copies) AAA_7 PF12775.7 KPI88626.1 - 0.048 13.2 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Flu_PB1 PF00602.17 KPI88626.1 - 0.11 10.6 0.0 0.14 10.2 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Ank_5 PF13857.6 KPI88626.1 - 0.12 12.7 0.1 2.2 8.7 0.1 2.9 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Pkinase PF00069.25 KPI88627.1 - 1.9e-57 194.6 0.0 3.1e-57 193.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88627.1 - 5.1e-35 121.0 0.0 8.9e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.25 KPI88627.1 - 2.6e-07 30.6 0.0 5.9e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold Kinase-like PF14531.6 KPI88627.1 - 2.4e-06 27.1 0.0 0.00013 21.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI88627.1 - 6.4e-06 25.2 0.0 1.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase PAS_9 PF13426.7 KPI88627.1 - 3.4e-05 24.0 0.0 9.9e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 PAS domain Kdo PF06293.14 KPI88627.1 - 4e-05 23.1 0.1 0.0004 19.8 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_4 PF08448.10 KPI88627.1 - 0.0011 19.2 0.0 0.0027 18.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold APH PF01636.23 KPI88627.1 - 0.02 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PAS_10 PF13596.6 KPI88627.1 - 0.032 14.8 0.0 0.07 13.7 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_8 PF13188.7 KPI88627.1 - 0.042 13.9 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain FTA2 PF13095.6 KPI88627.1 - 0.051 13.2 0.0 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SHNi-TPR PF10516.9 KPI88629.1 - 0.18 11.3 0.0 0.38 10.2 0.0 1.5 1 0 0 1 1 1 0 SHNi-TPR Ribosomal_L7Ae PF01248.26 KPI88630.1 - 7.1e-23 80.2 1.4 8.7e-23 79.9 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.12 KPI88630.1 - 0.068 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding SEEK1 PF15357.6 KPI88631.1 - 0.039 14.1 4.2 0.036 14.2 0.8 2.7 3 0 0 3 3 3 0 Psoriasis susceptibility 1 candidate 1 MCU PF04678.13 KPI88633.1 - 5e-13 49.5 0.2 6e-13 49.3 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF2935 PF11155.8 KPI88633.1 - 0.035 14.4 0.0 0.55 10.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DmpG_comm PF07836.11 KPI88633.1 - 0.09 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 DmpG-like communication domain Acetyltransf_10 PF13673.7 KPI88634.1 - 4.9e-06 26.5 0.0 8.7e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI88634.1 - 4.5e-05 23.8 0.0 0.00019 21.8 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 KPI88634.1 - 0.00091 19.9 0.7 0.043 14.5 0.1 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI88634.1 - 0.0024 18.1 0.0 0.0044 17.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family ALG11_N PF15924.5 KPI88634.1 - 0.087 12.9 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 ALG11 mannosyltransferase N-terminus DASH_Dam1 PF08653.10 KPI88636.1 - 0.035 13.9 0.0 0.085 12.7 0.0 1.6 1 0 0 1 1 1 0 DASH complex subunit Dam1 Pilosulin PF17499.2 KPI88636.1 - 0.043 14.0 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 Ant venom peptides Polysacc_deac_1 PF01522.21 KPI88637.1 - 1.6e-07 31.2 0.0 3.4e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Xpo1 PF08389.12 KPI88638.1 - 0.0023 18.0 0.1 0.11 12.5 0.0 3.0 3 0 0 3 3 3 1 Exportin 1-like protein HEAT_EZ PF13513.6 KPI88638.1 - 0.0057 17.1 0.2 0.0057 17.1 0.2 4.3 6 0 0 6 6 6 1 HEAT-like repeat Cse1 PF08506.10 KPI88638.1 - 0.012 14.4 0.0 0.026 13.3 0.0 1.5 1 0 0 1 1 1 0 Cse1 HEAT PF02985.22 KPI88638.1 - 0.019 15.2 4.5 0.13 12.6 0.1 4.5 4 0 0 4 4 4 0 HEAT repeat SDA1 PF05285.12 KPI88638.1 - 0.021 14.3 12.4 0.032 13.7 12.4 1.2 1 0 0 1 1 1 0 SDA1 Cnd1 PF12717.7 KPI88638.1 - 0.14 12.2 0.0 0.6 10.1 0.0 1.9 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 KPI88638.1 - 0.3 11.3 2.0 14 5.9 0.0 3.6 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DHHC PF01529.20 KPI88639.1 - 4.9e-19 68.8 13.5 4.9e-19 68.8 13.5 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Fer4 PF00037.27 KPI88639.1 - 2.6 8.0 8.8 13 5.8 1.0 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain U-box PF04564.15 KPI88640.1 - 1.5e-06 28.2 0.0 3.7e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 KPI88640.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Lectin_leg-like PF03388.13 KPI88641.1 - 2.4e-50 171.0 0.0 3e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 KPI88641.1 - 2.6e-12 47.2 0.1 4.6e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 KPI88641.1 - 0.00049 19.7 0.0 0.0024 17.5 0.0 1.9 1 1 0 1 1 1 1 Legume lectin domain Peptidase_M24 PF00557.24 KPI88642.1 - 1.7e-13 50.7 0.3 1.1e-12 48.1 0.3 2.1 1 1 0 1 1 1 1 Metallopeptidase family M24 KIP1 PF07765.12 KPI88642.1 - 0.21 11.7 0.5 1.3 9.2 0.1 2.2 2 0 0 2 2 2 0 KIP1-like protein End3 PF12761.7 KPI88642.1 - 0.49 10.5 7.6 0.98 9.6 7.6 1.5 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 PSP1 PF04468.12 KPI88643.1 - 2.3e-20 72.6 0.0 4.6e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region AsmA PF05170.14 KPI88643.1 - 0.59 8.9 4.2 0.93 8.2 4.2 1.2 1 0 0 1 1 1 0 AsmA family Kinesin PF00225.23 KPI88644.1 - 1.9e-36 125.7 0.0 1.1e-07 31.2 0.0 5.1 5 0 0 5 5 5 5 Kinesin motor domain Microtub_bd PF16796.5 KPI88644.1 - 6.3e-08 32.7 0.0 2.6e-06 27.5 0.0 2.8 2 1 0 2 2 2 1 Microtubule binding K-box PF01486.17 KPI88644.1 - 0.022 14.9 0.6 0.059 13.6 0.6 1.7 1 0 0 1 1 1 0 K-box region zf-RNPHF PF08080.12 KPI88644.1 - 0.37 10.8 2.1 3.6 7.6 0.5 2.6 2 0 0 2 2 2 0 RNPHF zinc finger SlyX PF04102.12 KPI88644.1 - 5 7.8 5.3 8.5 7.1 3.4 2.4 1 1 0 2 2 2 0 SlyX ArfGap PF01412.18 KPI88645.1 - 9.5e-30 103.1 0.1 1.8e-29 102.2 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ADH_N PF08240.12 KPI88646.1 - 3.1e-10 39.9 0.5 9.1e-10 38.4 0.0 2.0 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ubiquitin PF00240.23 KPI88647.1 - 1.2e-11 44.2 0.0 2.6e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 KPI88647.1 - 0.00062 19.9 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 KPI88647.1 - 0.0029 17.4 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KPI88647.1 - 0.0071 16.8 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 KPI88647.1 - 0.02 15.4 0.0 0.094 13.3 0.0 2.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Anoctamin PF04547.12 KPI88648.1 - 2.8e-84 283.5 3.7 3.6e-84 283.2 3.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Bact_transglu_N PF08379.10 KPI88648.1 - 0.08 13.9 0.0 0.29 12.0 0.0 1.9 1 0 0 1 1 1 0 Bacterial transglutaminase-like N-terminal region C2 PF00168.30 KPI88650.1 - 1.3e-21 76.8 0.0 2.7e-21 75.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain DSPc PF00782.20 KPI88651.1 - 1.3e-06 28.3 0.1 3.1e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF5047 PF16466.5 KPI88651.1 - 0.053 13.9 0.5 0.16 12.4 0.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5047) Pkinase PF00069.25 KPI88652.1 - 4e-41 141.1 0.0 1.8e-34 119.3 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88652.1 - 2.7e-17 62.9 0.0 1.9e-16 60.1 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI88652.1 - 2.3e-05 23.9 0.0 0.00022 20.7 0.0 2.3 2 1 1 3 3 3 1 Kinase-like Pox_F15 PF04596.12 KPI88652.1 - 0.082 12.7 0.0 6.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Poxvirus protein F15 MatE PF01554.18 KPI88653.1 - 4.5e-31 107.7 29.9 1.2e-15 57.6 10.2 2.3 2 0 0 2 2 2 2 MatE CbiG_C PF01890.16 KPI88654.1 - 0.0025 18.3 1.6 1.6 9.3 0.3 2.5 2 0 0 2 2 2 2 Cobalamin synthesis G C-terminus CTU2 PF10288.9 KPI88654.1 - 0.0056 16.9 9.2 0.0056 16.9 9.2 2.5 2 1 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.20 KPI88654.1 - 0.078 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 PP-loop family Complex1_LYR_2 PF13233.6 KPI88657.1 - 6.3e-06 26.9 0.0 1.3e-05 25.8 0.0 1.5 1 1 0 1 1 1 1 Complex1_LYR-like LTXXQ PF07813.12 KPI88657.1 - 0.24 12.1 4.1 1.4 9.7 0.1 2.9 3 0 0 3 3 3 0 LTXXQ motif family protein Peptidase_M16_C PF05193.21 KPI88662.1 - 1.8e-05 24.8 0.0 0.00019 21.5 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KPI88662.1 - 3.2e-05 23.9 0.0 0.00078 19.4 0.0 2.4 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) YfkD PF14167.6 KPI88662.1 - 0.084 12.1 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 YfkD-like protein ELO PF01151.18 KPI88663.1 - 4.8e-19 68.9 0.2 6.5e-19 68.4 0.2 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88664.1 - 1.2e-39 136.4 10.3 1.4e-39 136.1 10.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Atthog PF18800.1 KPI88664.1 - 0.26 11.2 5.3 0.32 10.9 5.3 1.1 1 0 0 1 1 1 0 Attenuator of Hedgehog ELO PF01151.18 KPI88665.1 - 2.4e-69 233.6 9.8 3.2e-69 233.2 9.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88666.1 - 9.9e-74 248.0 23.0 1.3e-73 247.6 23.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88667.1 - 3.3e-80 269.2 19.9 3.8e-80 269.0 19.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88668.1 - 1.2e-70 237.9 6.5 1.4e-70 237.7 6.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88669.1 - 3.7e-58 197.0 9.6 4.3e-58 196.8 9.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88670.1 - 5.8e-45 153.8 7.8 6.5e-45 153.6 7.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88671.1 - 6.1e-59 199.6 17.2 7.1e-59 199.3 17.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 KPI88672.1 - 1.8e-63 214.4 19.5 2e-63 214.2 19.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family UPF0172 PF03665.13 KPI88673.1 - 6.1e-48 163.4 0.0 7.2e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) LRR_4 PF12799.7 KPI88674.1 - 0.0006 20.2 2.2 0.0092 16.4 1.7 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88674.1 - 0.15 11.8 4.4 0.59 9.9 2.6 2.1 1 1 1 2 2 2 0 Leucine rich repeat Flagellar_rod PF05149.12 KPI88675.1 - 2.3e-12 47.0 23.9 2.3e-12 47.0 23.9 2.4 3 0 0 3 3 3 1 Paraflagellar rod protein DUF2935 PF11155.8 KPI88675.1 - 0.19 12.0 1.9 21 5.4 0.4 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Fungal_trans_2 PF11951.8 KPI88675.1 - 6.7 5.4 8.0 0.24 10.2 0.2 2.4 3 0 0 3 3 3 0 Fungal specific transcription factor domain ABA_GPCR PF12430.8 KPI88677.1 - 1.3e-26 93.5 0.4 1.3e-26 93.5 0.4 2.0 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 KPI88677.1 - 4.6e-07 29.8 0.0 1.7e-06 28.0 0.0 1.9 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal NUDIX PF00293.28 KPI88678.1 - 1.1e-07 32.0 0.0 2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DEAD PF00270.29 KPI88679.1 - 5.2e-46 156.6 0.0 1.1e-45 155.5 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88679.1 - 3.3e-24 85.4 0.0 2.2e-23 82.7 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88679.1 - 0.0012 18.9 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KPI88679.1 - 0.0056 16.0 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 KPI88679.1 - 0.11 12.8 1.0 0.67 10.2 0.4 2.5 1 1 1 2 2 2 0 AAA domain Helicase_C_2 PF13307.6 KPI88679.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain DUF1674 PF07896.12 KPI88681.1 - 1.3e-14 54.3 0.1 1.9e-14 53.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) Rav1p_C PF12234.8 KPI88682.1 - 3.5e-38 131.5 0.1 7e-37 127.1 0.1 2.5 1 1 0 1 1 1 1 RAVE protein 1 C terminal EamA PF00892.20 KPI88684.1 - 1.2e-14 54.6 28.1 1.9e-08 34.5 2.9 3.2 3 0 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 KPI88684.1 - 3.9e-10 39.7 3.8 3.9e-10 39.7 3.8 1.7 2 0 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 KPI88684.1 - 2.4e-06 27.0 0.3 2.4e-06 27.0 0.3 1.9 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport TPT PF03151.16 KPI88684.1 - 3.8e-05 23.2 1.3 6.5e-05 22.4 1.3 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KPI88684.1 - 0.00086 18.6 5.5 0.00086 18.6 5.5 1.6 2 0 0 2 2 2 1 UAA transporter family TMEM234 PF10639.9 KPI88684.1 - 0.065 13.3 2.0 0.46 10.5 0.1 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 SIN1_PH PF16979.5 KPI88685.1 - 1.2e-10 41.6 0.2 2.5e-10 40.6 0.2 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology N2227 PF07942.12 KPI88685.1 - 0.031 13.5 0.0 0.055 12.7 0.0 1.3 1 0 0 1 1 1 0 N2227-like protein MaoC_dehydratas PF01575.19 KPI88687.1 - 1.5e-20 73.0 0.0 2.6e-20 72.2 0.0 1.4 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 KPI88687.1 - 4.9e-13 49.4 0.0 6.6e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.22 KPI88687.1 - 0.021 15.2 0.0 0.058 13.7 0.0 1.8 2 0 0 2 2 2 0 Thioesterase superfamily MaoC_dehydratas PF01575.19 KPI88688.1 - 2.1e-21 75.8 0.0 2.8e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 KPI88688.1 - 8.2e-09 35.7 0.0 1.2e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT_2 PF13279.6 KPI88688.1 - 0.0038 17.7 0.0 0.0042 17.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 KPI88688.1 - 0.0054 17.1 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-CoA_dh_N PF02771.16 KPI88690.1 - 3.2e-10 40.7 0.0 8.8e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KPI88690.1 - 0.001 19.2 0.5 0.0034 17.5 0.2 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain RIBIOP_C PF04950.12 KPI88691.1 - 4e-94 315.3 0.0 6.3e-94 314.7 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KPI88691.1 - 2.6e-18 65.9 0.0 7.7e-18 64.4 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain MATalpha_HMGbox PF04769.12 KPI88691.1 - 0.017 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box GST_N PF02798.20 KPI88692.1 - 0.051 13.9 0.0 0.073 13.4 0.0 1.4 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DHC_N2 PF08393.13 KPI88693.1 - 2.4e-37 129.0 0.2 8e-37 127.3 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 KPI88693.1 - 2.1e-12 46.9 0.0 2.7e-10 40.0 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_6 PF12774.7 KPI88693.1 - 0.00019 20.5 0.0 0.00042 19.4 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 KPI88693.1 - 0.042 13.2 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 YtzH PF14165.6 KPI88693.1 - 0.44 11.0 1.6 1 9.8 0.7 2.1 2 0 0 2 2 2 0 YtzH-like protein HalX PF08663.10 KPI88693.1 - 2.1 8.7 5.3 0.53 10.6 0.2 2.8 2 0 0 2 2 2 0 HalX domain Amastin PF07344.11 KPI88694.1 - 5.9e-38 130.2 7.3 7.2e-38 129.9 7.3 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein MARVEL PF01284.23 KPI88694.1 - 0.0098 15.9 1.1 0.0098 15.9 1.1 2.6 1 1 0 2 2 2 1 Membrane-associating domain MMR_HSR1 PF01926.23 KPI88695.1 - 2.7e-07 30.7 0.0 0.00012 22.1 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 KPI88695.1 - 0.00019 21.3 0.0 0.0022 17.8 0.0 2.4 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 KPI88695.1 - 0.00034 20.2 0.1 0.18 11.4 0.0 2.7 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 KPI88695.1 - 0.0013 18.3 0.0 0.0029 17.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KPI88695.1 - 0.018 14.9 0.0 0.18 11.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 KPI88695.1 - 0.026 14.6 0.0 0.08 13.0 0.0 1.8 1 1 0 1 1 1 0 Dynamin family Prefoldin_2 PF01920.20 KPI88696.1 - 1.8e-07 31.1 4.1 1.8e-07 31.1 4.1 1.5 1 1 0 1 1 1 1 Prefoldin subunit UPF0242 PF06785.11 KPI88696.1 - 0.0015 18.6 2.5 0.002 18.2 2.5 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 KPI88696.1 - 0.018 14.4 1.0 0.018 14.4 1.0 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SCF PF02404.15 KPI88697.1 - 0.093 12.1 0.1 16 4.7 0.1 3.1 2 1 1 3 3 3 0 Stem cell factor MIT PF04212.18 KPI88697.1 - 0.81 9.8 7.0 0.47 10.6 3.4 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Seryl_tRNA_N PF02403.22 KPI88697.1 - 5 7.4 9.4 0.33 11.2 2.1 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Methyltransf_PK PF05891.12 KPI88698.1 - 3.5e-62 209.8 0.0 4.2e-62 209.5 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KPI88698.1 - 4.4e-11 43.3 0.0 7.1e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI88698.1 - 4.5e-10 40.1 0.0 6.8e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI88698.1 - 7.9e-07 29.0 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KPI88698.1 - 1.1e-05 25.1 0.0 1.8e-05 24.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 KPI88698.1 - 2.2e-05 25.1 0.0 3.6e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI88698.1 - 2.2e-05 24.3 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KPI88698.1 - 0.00077 18.8 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Bin3 PF06859.12 KPI88698.1 - 0.18 12.5 0.0 0.31 11.7 0.0 1.4 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) FA_desaturase PF00487.24 KPI88699.1 - 0.5 10.2 3.8 0.76 9.6 3.8 1.2 1 0 0 1 1 1 0 Fatty acid desaturase FBP_C PF16571.5 KPI88700.1 - 0.14 11.6 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger Pkinase PF00069.25 KPI88701.1 - 2.6e-69 233.6 0.0 3.4e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88701.1 - 1.1e-30 106.8 0.0 1.6e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KPI88701.1 - 1.3e-08 35.2 0.2 2.8e-08 34.2 0.2 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 KPI88701.1 - 1.4e-05 24.6 0.0 5.6e-05 22.6 0.0 2.0 2 1 0 2 2 2 1 Kinase-like PH_11 PF15413.6 KPI88701.1 - 0.012 16.0 1.6 0.38 11.2 1.6 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain Kdo PF06293.14 KPI88701.1 - 0.024 14.0 0.0 0.046 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI88701.1 - 0.078 11.7 0.1 0.22 10.3 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase Pkinase_C PF00433.24 KPI88701.1 - 0.11 13.3 0.1 0.44 11.3 0.0 2.1 2 1 0 2 2 2 0 Protein kinase C terminal domain APH PF01636.23 KPI88701.1 - 0.12 12.3 0.0 0.54 10.1 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family PET117 PF15786.5 KPI88703.1 - 0.082 13.2 0.1 0.32 11.3 0.0 2.1 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial Gasdermin PF04598.12 KPI88703.1 - 0.12 11.8 0.1 0.78 9.1 0.1 2.0 2 0 0 2 2 2 0 Gasdermin pore forming domain Choline_sulf_C PF12411.8 KPI88704.1 - 0.0026 17.5 0.1 0.33 10.8 0.1 2.4 2 0 0 2 2 2 2 Choline sulfatase enzyme C terminal Arm PF00514.23 KPI88705.1 - 2.7e-25 87.6 20.1 0.0063 16.5 0.0 13.3 13 0 0 13 13 13 9 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KPI88705.1 - 1.8e-17 63.1 14.5 0.0044 17.0 0.0 8.8 3 3 5 9 9 9 7 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.6 KPI88705.1 - 2.6e-06 27.7 9.2 0.032 14.6 0.4 5.9 4 1 1 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 KPI88705.1 - 4.6e-05 23.8 9.8 0.27 11.8 0.4 5.9 5 1 0 5 5 5 2 HEAT-like repeat SAWADEE PF16719.5 KPI88705.1 - 0.12 12.4 1.0 0.29 11.1 0.2 2.1 2 1 0 2 2 2 0 SAWADEE domain ESCRT-II PF05871.12 KPI88705.1 - 7.5 6.8 5.3 90 3.3 1.5 4.0 3 2 1 4 4 4 0 ESCRT-II complex subunit DJ-1_PfpI PF01965.24 KPI88707.1 - 2.7e-39 134.6 0.1 3.2e-39 134.4 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GrpE PF01025.19 KPI88710.1 - 1e-32 113.1 1.3 1.2e-32 112.9 1.3 1.0 1 0 0 1 1 1 1 GrpE PBECR5 PF18814.1 KPI88710.1 - 0.02 14.9 0.3 0.022 14.7 0.3 1.1 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 TSNAXIP1_N PF15739.5 KPI88710.1 - 0.025 14.9 4.6 0.048 14.1 4.6 1.4 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus DUF3967 PF13152.6 KPI88710.1 - 0.34 10.7 2.7 13 5.7 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3967) Ead_Ea22 PF13935.6 KPI88710.1 - 0.71 10.5 6.1 1.3 9.7 6.1 1.6 1 1 0 1 1 1 0 Ead/Ea22-like protein GrpE PF01025.19 KPI88711.1 - 2.5e-40 137.9 1.4 3e-40 137.6 1.4 1.1 1 0 0 1 1 1 1 GrpE TPR_2 PF07719.17 KPI88713.1 - 4.2e-23 79.6 14.1 0.0047 16.9 0.9 8.7 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 KPI88713.1 - 1.5e-21 75.2 9.3 0.0019 18.0 0.0 7.1 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 KPI88713.1 - 1.1e-15 56.4 12.6 0.0019 18.1 0.0 7.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 KPI88713.1 - 1.3e-15 56.2 7.7 0.013 15.7 0.0 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KPI88713.1 - 1.3e-13 51.1 12.2 2e-05 24.8 0.2 6.3 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KPI88713.1 - 1.4e-09 38.4 13.0 0.0013 19.3 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI88713.1 - 2.1e-09 37.4 7.2 2.3 9.2 0.1 7.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI88713.1 - 2.1e-08 34.6 2.3 0.025 15.1 0.0 5.3 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI88713.1 - 5e-08 32.8 2.4 0.84 10.2 0.0 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 KPI88713.1 - 1.2e-07 31.9 13.3 0.02 15.5 0.1 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI88713.1 - 2.3e-07 30.4 5.8 0.025 14.3 0.0 5.9 5 2 2 7 7 6 2 TPR repeat TPR_9 PF13371.6 KPI88713.1 - 2.9e-06 27.4 0.9 0.91 9.7 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat SNAP PF14938.6 KPI88713.1 - 1.2e-05 24.9 5.7 0.0017 17.9 2.6 3.2 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 KPI88713.1 - 0.0015 18.7 22.4 0.2 11.9 9.1 4.9 3 3 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 KPI88713.1 - 0.0019 17.5 1.0 0.3 10.3 0.0 3.7 1 1 2 4 4 4 1 Tetratricopeptide repeat DUF3808 PF10300.9 KPI88713.1 - 0.055 12.2 1.2 0.27 9.9 0.0 2.3 1 1 1 3 3 3 0 Protein of unknown function (DUF3808) Sel1 PF08238.12 KPI88713.1 - 0.15 12.8 11.0 4.8 8.0 0.4 5.2 5 1 0 5 5 4 0 Sel1 repeat UPF0061 PF02696.14 KPI88713.1 - 0.16 10.7 0.1 0.25 10.0 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family DUF3856 PF12968.7 KPI88713.1 - 0.21 11.7 0.7 1.9 8.6 0.2 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF3856) BTAD PF03704.17 KPI88713.1 - 0.67 10.4 11.1 1.3 9.4 0.0 3.9 4 0 0 4 4 4 0 Bacterial transcriptional activator domain MIT PF04212.18 KPI88713.1 - 8.2 6.6 11.7 58 3.9 0.1 5.7 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain PcfJ PF14284.6 KPI88714.1 - 0.15 11.9 1.2 0.41 10.5 0.0 2.1 2 1 1 3 3 3 0 PcfJ-like protein Peptidase_S32 PF05579.13 KPI88714.1 - 0.16 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Ribosomal_S30 PF04758.14 KPI88716.1 - 3.3e-25 88.0 8.4 3.8e-25 87.9 8.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 PDZ_2 PF13180.6 KPI88717.1 - 5.8e-09 36.2 0.0 1.7e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PI-PLC-X PF00388.19 KPI88717.1 - 4.8e-08 32.7 0.0 1.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PDZ_6 PF17820.1 KPI88717.1 - 1.8e-05 24.5 0.0 0.00012 21.8 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KPI88717.1 - 0.00035 20.9 0.0 0.00095 19.5 0.0 1.7 1 0 0 1 1 1 1 PDZ domain DUF444 PF04285.12 KPI88717.1 - 0.011 14.8 0.1 0.018 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF444) Ribo_biogen_C PF04034.13 KPI88717.1 - 0.02 14.6 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 Ribosome biogenesis protein, C-terminal EF-hand_like PF09279.11 KPI88717.1 - 0.3 11.6 1.0 0.62 10.6 0.1 2.0 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like DUF1965 PF09248.10 KPI88718.1 - 0.048 13.4 0.1 0.14 11.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) CedA PF10729.9 KPI88718.1 - 0.072 12.9 0.0 0.28 11.1 0.0 2.0 1 0 0 1 1 1 0 Cell division activator CedA Hist_rich_Ca-bd PF10529.9 KPI88719.1 - 0.72 10.2 4.4 1.8 8.9 4.4 1.7 1 0 0 1 1 1 0 Histidine-rich Calcium-binding repeat region Hexapep PF00132.24 KPI88720.1 - 1.2e-05 24.8 0.3 1.3 8.9 0.1 4.2 3 1 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) tRNA-synt_His PF13393.6 KPI88721.1 - 9.4e-34 117.1 0.0 1.5e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 KPI88721.1 - 2.6e-09 37.1 0.1 7.3e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KPI88721.1 - 1.9e-05 24.7 0.0 2.7e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) RRS1 PF04939.12 KPI88722.1 - 1.7e-40 138.6 7.2 1.7e-40 138.6 7.2 1.5 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) EMC3_TMCO1 PF01956.16 KPI88722.1 - 5 6.8 6.2 11 5.7 6.2 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Cyt-b5 PF00173.28 KPI88723.1 - 9.7e-22 76.9 0.0 9.1e-13 48.2 0.0 2.4 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.21 KPI88723.1 - 1.1e-06 29.2 0.0 4.8e-06 27.2 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KPI88723.1 - 0.0001 22.6 0.0 0.00021 21.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KPI88723.1 - 0.02 15.0 0.0 0.16 12.1 0.0 2.1 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Pkinase PF00069.25 KPI88724.1 - 5.8e-68 229.1 0.0 7.6e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88724.1 - 1e-40 139.7 0.0 1.4e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI88724.1 - 3.5e-06 26.6 0.0 7.3e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI88724.1 - 0.0047 15.8 0.4 0.012 14.4 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 KPI88724.1 - 0.018 14.6 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family BBS2_C PF14782.6 KPI88725.1 - 1.3e-114 383.3 0.0 2e-114 382.8 0.0 1.3 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid PF14783.6 KPI88725.1 - 4.7e-25 87.7 0.0 6.1e-24 84.1 0.0 2.9 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region BBS2_N PF14781.6 KPI88725.1 - 2.4e-21 75.6 0.0 7.6e-21 74.0 0.0 1.9 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, N-terminal VCBS PF13517.6 KPI88725.1 - 0.001 19.6 1.7 0.023 15.3 0.4 2.7 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KPI88725.1 - 0.0026 17.9 0.4 0.011 15.9 0.4 2.0 1 0 0 1 1 1 1 FG-GAP repeat APG6_N PF17675.1 KPI88725.1 - 0.27 11.8 4.3 0.15 12.6 0.4 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region FlgN PF05130.12 KPI88725.1 - 2.6 8.5 7.4 0.58 10.7 1.8 2.4 2 1 0 2 2 2 0 FlgN protein AMP-binding PF00501.28 KPI88726.1 - 7.5e-25 87.4 0.1 1.1e-11 44.1 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme PSP PF04046.16 KPI88727.1 - 3e-18 65.4 3.1 7.4e-18 64.2 3.1 1.7 1 0 0 1 1 1 1 PSP DUF382 PF04037.13 KPI88727.1 - 5.9e-11 42.6 3.1 2.8e-10 40.4 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF382) LUC7 PF03194.15 KPI88727.1 - 0.063 12.9 1.5 0.081 12.6 1.5 1.2 1 0 0 1 1 1 0 LUC7 N_terminus DUF4878 PF12870.7 KPI88728.1 - 0.11 12.8 3.9 0.25 11.7 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4878) LMBR1 PF04791.16 KPI88729.1 - 1.2e-55 189.4 25.5 1.5e-55 189.1 25.5 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF1700 PF08006.11 KPI88729.1 - 0.21 11.1 5.9 0.86 9.1 5.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) RRM_1 PF00076.22 KPI88730.1 - 3e-17 62.2 0.0 4.2e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI88730.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Alg14 PF08660.11 KPI88731.1 - 3e-52 177.1 0.0 4.3e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_tran_28_C PF04101.16 KPI88731.1 - 4.5e-19 69.0 0.0 7.8e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SKG6 PF08693.10 KPI88731.1 - 0.025 14.0 0.9 0.062 12.7 0.9 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain NatB_MDM20 PF09797.9 KPI88732.1 - 3.5e-26 92.0 0.0 1.1e-24 87.2 0.0 2.3 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit DUF997 PF06196.12 KPI88732.1 - 0.084 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF997) TPR_16 PF13432.6 KPI88732.1 - 0.11 13.1 1.6 0.27 11.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI88732.1 - 0.11 13.3 3.6 1.1 10.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KPI88732.1 - 0.14 12.6 3.7 0.15 12.5 0.6 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Mic1 PF07035.12 KPI88732.1 - 0.55 9.9 3.2 2 8.1 0.2 3.0 3 0 0 3 3 3 0 Colon cancer-associated protein Mic1-like LRR_4 PF12799.7 KPI88733.1 - 1.7e-05 25.1 0.0 0.0046 17.4 0.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI88733.1 - 0.18 11.9 0.2 12 6.3 0.0 3.6 3 0 0 3 3 3 0 Leucine Rich repeat YL1 PF05764.13 KPI88734.1 - 0.28 11.3 10.6 0.1 12.7 3.7 2.2 2 0 0 2 2 2 0 YL1 nuclear protein TFIIF_alpha PF05793.12 KPI88734.1 - 6.6 5.2 9.8 12 4.4 9.8 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 KPI88735.1 - 0.45 8.6 9.5 0.87 7.6 9.5 1.4 1 0 0 1 1 1 0 DNA polymerase phi FAM76 PF16046.5 KPI88735.1 - 3.1 7.1 8.9 8 5.7 8.9 1.7 1 0 0 1 1 1 0 FAM76 protein RRN3 PF05327.11 KPI88735.1 - 8.4 4.8 7.8 0.14 10.7 0.3 1.6 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Bystin PF05291.11 KPI88736.1 - 5e-111 370.7 0.4 6.9e-111 370.2 0.4 1.1 1 0 0 1 1 1 1 Bystin DUF3299 PF11736.8 KPI88736.1 - 0.14 12.1 0.0 0.41 10.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) tRNA-synt_2 PF00152.20 KPI88738.1 - 5.3e-75 252.4 0.2 7.1e-75 252.0 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KPI88738.1 - 1.6e-10 40.8 0.1 2.9e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KPI88738.1 - 0.0012 18.4 0.0 0.18 11.3 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) IF4E PF01652.18 KPI88739.1 - 2.9e-26 92.2 0.1 3.9e-26 91.8 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PAM2 PF07145.15 KPI88739.1 - 0.0047 16.5 0.3 0.014 15.0 0.3 1.9 1 0 0 1 1 1 1 Ataxin-2 C-terminal region RRF PF01765.19 KPI88740.1 - 1e-12 48.3 2.3 1e-12 48.3 2.3 1.8 1 1 1 2 2 2 1 Ribosome recycling factor PA28_alpha PF02251.18 KPI88740.1 - 0.036 14.1 0.1 0.12 12.4 0.1 1.9 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit FAD-oxidase_C PF02913.19 KPI88741.1 - 0.00079 19.1 0.2 0.00092 18.9 0.2 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain zf-C2HC_2 PF13913.6 KPI88742.1 - 4.5e-12 45.5 4.1 1.4e-10 40.8 1.6 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 KPI88742.1 - 0.049 14.5 0.5 0.12 13.2 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI88742.1 - 0.053 14.0 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-FPG_IleRS PF06827.14 KPI88742.1 - 0.35 10.8 2.0 0.73 9.8 2.0 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS FHA PF00498.26 KPI88743.1 - 1.9e-07 31.3 0.0 3.6e-06 27.2 0.0 2.5 2 1 0 2 2 2 1 FHA domain PARM PF17061.5 KPI88744.1 - 0.049 13.8 8.4 0.062 13.4 8.4 1.1 1 0 0 1 1 1 0 PARM MSA-2c PF12238.8 KPI88744.1 - 7.4 6.5 7.8 9.4 6.2 7.8 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c TPR_2 PF07719.17 KPI88745.1 - 1.9e-08 33.8 11.5 0.055 13.6 0.0 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI88745.1 - 3.4e-08 34.0 4.4 5.5e-06 26.9 1.2 3.5 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI88745.1 - 3.1e-07 29.9 0.5 0.12 12.2 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KPI88745.1 - 4e-07 30.1 1.5 3.1e-06 27.3 0.8 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KPI88745.1 - 6e-06 26.3 0.6 0.04 14.3 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI88745.1 - 1e-05 25.1 1.7 0.78 9.5 0.1 3.4 2 1 1 3 3 3 3 TPR repeat TPR_15 PF13429.6 KPI88745.1 - 4.1e-05 22.9 3.5 0.00015 21.1 0.1 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.8 KPI88745.1 - 0.00071 18.6 0.2 0.00071 18.6 0.2 3.0 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 KPI88745.1 - 0.0029 18.1 7.9 0.11 13.0 0.2 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI88745.1 - 0.029 15.2 13.8 1 10.3 0.1 5.0 3 1 2 5 5 5 0 Tetratricopeptide repeat ArfGap PF01412.18 KPI88746.1 - 2.3e-36 124.4 0.9 3.2e-36 123.9 0.0 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf T2SSF PF00482.23 KPI88746.1 - 0.26 11.3 0.5 0.83 9.6 0.0 1.9 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F UBA_4 PF14555.6 KPI88747.1 - 2.3e-08 33.7 0.0 3.6e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 KPI88747.1 - 0.009 16.2 0.1 0.024 14.8 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like zf-met PF12874.7 KPI88749.1 - 0.0035 17.7 0.5 0.0074 16.6 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type AKAP95 PF04988.12 KPI88749.1 - 0.043 14.0 0.1 0.057 13.6 0.1 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Pkinase PF00069.25 KPI88750.1 - 1.4e-42 145.9 0.0 2.8e-20 72.8 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88750.1 - 6e-22 78.2 0.0 9.8e-13 48.0 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI88750.1 - 0.0021 17.5 0.0 0.87 8.8 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 KPI88750.1 - 0.0022 18.0 0.2 0.0083 16.1 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 KPI88750.1 - 0.012 15.1 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.11 KPI88750.1 - 0.072 12.1 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 KPI88750.1 - 0.13 11.8 0.4 0.47 10.0 0.4 1.8 1 1 0 1 1 1 0 RIO1 family C2-C2_1 PF11618.8 KPI88751.1 - 1.4e-08 34.9 4.0 1.6e-07 31.5 0.0 3.9 4 1 0 4 4 4 1 First C2 domain of RPGR-interacting protein 1 HIP1_clath_bdg PF16515.5 KPI88751.1 - 2.3 8.9 65.0 0.082 13.5 7.7 5.9 5 1 0 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1978 PF09321.10 KPI88751.1 - 8.1 5.7 21.7 0.018 14.3 10.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1978) RRM_1 PF00076.22 KPI88752.1 - 5.7e-16 58.1 0.0 4.4e-07 29.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_pol_Rpb4 PF03874.16 KPI88753.1 - 0.00012 22.4 0.0 0.00017 21.9 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 Prolamin_like PF05617.11 KPI88753.1 - 0.061 13.5 0.1 0.087 13.0 0.1 1.3 1 0 0 1 1 1 0 Prolamin-like zf-CCCH PF00642.24 KPI88755.1 - 0.005 16.7 0.3 0.0079 16.1 0.3 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI88755.1 - 0.29 11.3 4.8 0.44 10.7 4.8 1.3 1 0 0 1 1 1 0 Zinc finger domain PPR_2 PF13041.6 KPI88756.1 - 0.0014 18.7 0.0 0.016 15.4 0.0 2.5 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 KPI88756.1 - 0.0052 16.9 0.0 9.5 6.7 0.0 3.8 4 0 0 4 4 4 1 PPR repeat PPR_3 PF13812.6 KPI88756.1 - 0.0054 16.8 0.0 0.018 15.1 0.0 1.9 1 1 0 1 1 1 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 KPI88756.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 PPR repeat TPR_4 PF07721.14 KPI88756.1 - 0.057 14.1 0.6 22 6.0 0.2 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Rad51 PF08423.11 KPI88757.1 - 3.8e-19 69.0 0.5 1.3e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 Rad51 RecA PF00154.21 KPI88757.1 - 8.7e-07 28.7 2.9 2.6e-05 23.8 0.1 2.2 2 0 0 2 2 2 2 recA bacterial DNA recombination protein ATPase PF06745.13 KPI88757.1 - 1.1e-05 24.9 0.1 3.5e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 KaiC DUF2075 PF09848.9 KPI88757.1 - 0.022 14.0 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 KPI88757.1 - 0.078 12.5 3.3 1.3 8.5 0.4 2.4 2 1 0 2 2 2 0 AAA domain HIP1_clath_bdg PF16515.5 KPI88758.1 - 0.0098 16.5 1.8 0.0098 16.5 1.8 5.2 5 1 1 6 6 6 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Filament PF00038.21 KPI88758.1 - 1.2 8.6 33.0 2.9 7.4 22.6 2.9 2 1 0 2 2 2 0 Intermediate filament protein Gly-zipper_OmpA PF13436.6 KPI88759.1 - 0.18 11.6 13.2 0.99 9.2 13.2 2.4 1 0 0 1 1 1 0 Glycine-zipper domain CaATP_NAI PF12515.8 KPI88762.1 - 0.019 14.6 0.0 0.048 13.3 0.0 1.7 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain F-box-like PF12937.7 KPI88762.1 - 0.02 14.8 0.6 0.065 13.1 0.6 1.9 1 0 0 1 1 1 0 F-box-like Cofilin_ADF PF00241.20 KPI88763.1 - 1e-30 106.0 0.1 1.1e-30 105.9 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein RNase_T PF00929.24 KPI88766.1 - 2.5e-27 96.5 0.0 3.2e-26 92.8 0.0 2.2 1 1 0 1 1 1 1 Exonuclease PRCC PF10253.9 KPI88766.1 - 0.65 10.7 7.3 1.2 9.8 7.3 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting RNase_T PF00929.24 KPI88767.1 - 6.3e-22 78.9 0.0 9.6e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 KPI88767.1 - 0.049 13.6 0.0 0.083 12.9 0.0 1.3 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like RNase_T PF00929.24 KPI88768.1 - 3.8e-28 99.1 0.1 5.3e-28 98.6 0.1 1.2 1 0 0 1 1 1 1 Exonuclease BatA PF07584.11 KPI88768.1 - 0.02 15.2 2.9 0.036 14.4 2.9 1.4 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal DUF5051 PF16473.5 KPI88768.1 - 0.026 14.5 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like DUF5345 PF17280.2 KPI88768.1 - 0.1 12.6 1.0 0.2 11.7 1.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Ank_4 PF13637.6 KPI88769.1 - 1.8e-11 44.3 0.1 6e-07 29.9 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI88769.1 - 1e-09 38.8 0.0 5.5e-06 26.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KPI88769.1 - 1.2e-07 31.8 1.1 0.026 14.9 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KPI88769.1 - 6.4e-07 29.2 0.5 0.067 13.8 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KPI88769.1 - 3.7e-05 23.9 0.5 0.48 10.8 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) tRNA_edit PF04073.15 KPI88769.1 - 0.15 12.1 0.2 0.41 10.7 0.1 1.7 2 0 0 2 2 2 0 Aminoacyl-tRNA editing domain IcmF-related PF06761.12 KPI88769.1 - 0.81 9.1 3.3 2.8 7.3 1.8 2.4 2 1 0 2 2 2 0 Intracellular multiplication and human macrophage-killing ERCC3_RAD25_C PF16203.5 KPI88771.1 - 7e-61 205.6 0.0 8.6e-55 185.6 0.0 2.3 2 0 0 2 2 2 2 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 KPI88771.1 - 7.3e-14 52.1 0.0 1.2e-13 51.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI88771.1 - 2e-09 37.8 0.0 5.8e-09 36.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_3 PF13625.6 KPI88771.1 - 1.6e-08 34.7 0.1 9.4e-08 32.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KPI88771.1 - 0.0013 17.5 0.0 0.0024 16.7 0.0 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain DEAD PF00270.29 KPI88771.1 - 0.0025 17.6 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-NF-X1 PF01422.17 KPI88772.1 - 4.2e-10 39.5 59.1 5e-06 26.5 14.6 13.7 13 0 0 13 13 13 5 NF-X1 type zinc finger zf-CCHC_2 PF13696.6 KPI88773.1 - 4.1e-09 36.1 3.7 9.1e-09 35.0 3.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-C2H2_jaz PF12171.8 KPI88773.1 - 0.007 16.6 0.1 0.007 16.6 0.1 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-CCHC_5 PF14787.6 KPI88773.1 - 0.016 14.9 2.9 0.047 13.4 2.9 1.8 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-C2H2 PF00096.26 KPI88773.1 - 0.016 15.6 0.3 0.016 15.6 0.3 3.6 3 1 0 3 3 3 0 Zinc finger, C2H2 type eIF3g PF12353.8 KPI88773.1 - 0.057 13.8 0.1 0.057 13.8 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-C2H2_4 PF13894.6 KPI88773.1 - 0.18 12.7 0.2 0.18 12.7 0.2 3.2 2 1 1 3 3 3 0 C2H2-type zinc finger zf-CCHC PF00098.23 KPI88773.1 - 0.23 11.6 2.3 0.59 10.3 2.3 1.8 1 0 0 1 1 1 0 Zinc knuckle zf_UBZ PF18439.1 KPI88773.1 - 2.9 7.5 9.5 14 5.4 0.1 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger ABC2_membrane_3 PF12698.7 KPI88774.1 - 2.4e-61 207.8 45.4 2.4e-42 145.3 17.8 3.3 3 0 0 3 3 3 3 ABC-2 family transporter protein ABC_tran PF00005.27 KPI88774.1 - 1.6e-53 180.9 0.0 2.3e-28 99.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KPI88774.1 - 6e-10 38.9 0.0 3.6e-05 23.3 0.0 3.0 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KPI88774.1 - 4.6e-09 36.5 5.6 0.0079 16.0 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI88774.1 - 0.00073 20.1 0.2 0.13 12.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI88774.1 - 0.00095 18.9 3.4 0.078 12.7 0.3 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KPI88774.1 - 0.0015 18.2 2.3 0.04 13.7 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 KPI88774.1 - 0.012 15.9 0.2 13 6.1 0.1 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 KPI88774.1 - 0.012 15.2 5.5 0.34 10.5 1.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KPI88774.1 - 0.024 14.2 1.6 3.6 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 KPI88774.1 - 0.025 14.5 0.0 3.9 7.4 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 KPI88774.1 - 0.6 10.5 3.4 14 6.1 0.1 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TTL PF03133.15 KPI88776.1 - 4.9e-45 153.9 0.0 6.8e-40 137.0 0.0 3.9 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KPI88776.1 - 0.22 10.7 0.0 1.6 7.9 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Tubulin_3 PF14881.6 KPI88777.1 - 3.4e-06 26.9 0.0 7.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 KPI88777.1 - 0.0014 19.0 1.8 0.0025 18.1 0.0 2.3 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 KPI88777.1 - 0.17 12.1 0.0 0.49 10.6 0.0 1.7 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain Pkinase PF00069.25 KPI88778.1 - 9.3e-56 189.1 0.0 2.2e-55 187.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88778.1 - 4.5e-36 124.5 0.0 7.1e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KPI88778.1 - 4.8e-15 55.4 0.2 3.8e-08 33.3 0.0 3.9 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain PAS PF00989.25 KPI88778.1 - 9.8e-07 28.8 0.0 2.7e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 KPI88778.1 - 6e-06 26.5 0.0 1.5e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 PAS domain Kinase-like PF14531.6 KPI88778.1 - 0.00013 21.4 0.0 0.00066 19.1 0.0 1.9 1 1 1 2 2 2 1 Kinase-like PAS_4 PF08448.10 KPI88778.1 - 0.00074 19.7 0.0 0.0035 17.6 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 KPI88778.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 PAS fold DUF816 PF05674.12 KPI88781.1 - 0.068 13.1 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF816) DUF775 PF05603.12 KPI88782.1 - 3.7e-24 85.4 0.0 5.8e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Tfb2 PF03849.14 KPI88783.1 - 0.12 11.3 0.2 0.17 10.8 0.2 1.2 1 0 0 1 1 1 0 Transcription factor Tfb2 HEAT PF02985.22 KPI88784.1 - 2.2e-28 95.8 40.4 0.0039 17.3 0.2 13.8 15 0 0 15 15 15 7 HEAT repeat HEAT_2 PF13646.6 KPI88784.1 - 4.6e-25 87.8 19.6 1e-06 29.0 0.4 8.1 2 2 4 7 7 7 7 HEAT repeats Cnd1 PF12717.7 KPI88784.1 - 2.1e-08 34.3 13.0 0.0033 17.5 0.2 5.8 3 1 4 7 7 7 5 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KPI88784.1 - 3.9e-06 27.2 22.9 0.0034 17.8 0.1 8.5 8 3 3 11 11 11 2 HEAT-like repeat CLASP_N PF12348.8 KPI88784.1 - 7.7e-05 22.4 1.3 0.015 14.8 0.3 3.7 2 2 1 3 3 3 1 CLASP N terminal Adaptin_N PF01602.20 KPI88784.1 - 0.00019 20.1 9.9 0.017 13.7 2.3 3.6 1 1 3 4 4 4 4 Adaptin N terminal region Arm PF00514.23 KPI88784.1 - 1.1 9.5 3.9 65 3.8 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Cohesin_HEAT PF12765.7 KPI88784.1 - 2.2 8.7 14.8 1.4 9.3 0.2 5.1 6 0 0 6 6 6 0 HEAT repeat associated with sister chromatid cohesion TPR_14 PF13428.6 KPI88785.1 - 9.9e-05 22.8 6.8 5.7 8.0 0.2 6.0 1 1 2 5 5 5 2 Tetratricopeptide repeat Suf PF05843.14 KPI88785.1 - 0.013 15.5 3.7 0.21 11.5 0.1 3.4 2 2 1 3 3 3 0 Suppressor of forked protein (Suf) TPR_2 PF07719.17 KPI88785.1 - 0.061 13.5 4.3 41 4.6 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Kinesin PF00225.23 KPI88786.1 - 1.6e-99 333.0 1.1 9.3e-74 248.3 0.5 2.4 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI88786.1 - 3.7e-24 85.4 1.9 3.1e-17 62.9 0.0 3.2 4 0 0 4 4 4 2 Microtubule binding ATG16 PF08614.11 KPI88786.1 - 0.0087 16.3 32.6 0.03 14.6 9.0 3.2 2 1 0 2 2 2 2 Autophagy protein 16 (ATG16) DUF812 PF05667.11 KPI88786.1 - 0.013 14.4 18.2 0.0043 16.0 4.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF812) APG6_N PF17675.1 KPI88786.1 - 0.15 12.6 32.1 0.019 15.5 8.8 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 KPI88786.1 - 0.48 9.3 25.5 0.081 11.8 5.3 3.1 3 0 0 3 3 3 0 Spc7 kinetochore protein MutS_III PF05192.18 KPI88786.1 - 0.78 9.9 9.4 0.27 11.5 2.5 2.5 2 0 0 2 2 2 0 MutS domain III Herpes_UL6 PF01763.16 KPI88786.1 - 0.87 8.0 8.9 0.21 10.1 1.1 2.2 2 0 0 2 2 2 0 Herpesvirus UL6 like CENP-B_dimeris PF09026.10 KPI88786.1 - 2.7 8.4 5.9 7.1 7.1 5.9 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4407 PF14362.6 KPI88786.1 - 3.6 6.9 23.5 0.66 9.3 9.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CLZ PF16526.5 KPI88786.1 - 4.2 7.8 16.6 3.8 7.9 3.7 3.6 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cep57_MT_bd PF06657.13 KPI88786.1 - 4.3 7.9 14.2 3.4 8.2 3.8 3.9 3 2 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 CENP-Q PF13094.6 KPI88787.1 - 0.095 12.9 5.0 0.15 12.2 3.3 2.3 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit OrfB_Zn_ribbon PF07282.11 KPI88788.1 - 3.1 7.8 6.1 26 4.8 2.3 2.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain NTP_transf_2 PF01909.23 KPI88789.1 - 0.00023 21.4 0.0 0.00041 20.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 KPI88789.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase MORN PF02493.20 KPI88791.1 - 3.4e-19 67.5 33.2 0.0019 17.9 0.3 6.5 6 0 0 6 6 6 6 MORN repeat Peptidase_S41_N PF11918.8 KPI88792.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP DUF4922 PF16269.5 KPI88792.1 - 0.32 10.7 0.7 0.52 10.0 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4922) CTP_synth_N PF06418.14 KPI88793.1 - 1.4e-105 352.4 0.0 1.8e-105 352.0 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 KPI88793.1 - 6.3e-42 143.5 0.0 2.6e-41 141.5 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KPI88793.1 - 1.4e-06 28.2 0.0 3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 DnaJ_C PF01556.18 KPI88794.1 - 3.7e-17 62.8 0.0 6.7e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KPI88794.1 - 1.3e-08 35.1 11.7 4.4e-08 33.4 11.7 2.0 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI88794.1 - 0.0011 18.9 10.5 0.15 12.1 1.8 2.8 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Rhv PF00073.20 KPI88794.1 - 0.029 14.0 0.2 0.068 12.8 0.0 1.6 2 0 0 2 2 2 0 picornavirus capsid protein DnaJ PF00226.31 KPI88794.1 - 0.15 12.2 0.2 0.56 10.4 0.2 2.1 1 1 0 1 1 1 0 DnaJ domain RWD PF05773.22 KPI88795.1 - 7e-10 39.2 0.6 1.1e-09 38.5 0.6 1.4 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 KPI88795.1 - 0.00058 20.3 1.0 0.001 19.5 1.0 1.4 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 phage_tail_N PF08400.10 KPI88795.1 - 0.093 12.7 1.0 0.55 10.2 0.1 2.3 1 1 0 2 2 2 0 Prophage tail fibre N-terminal MORN PF02493.20 KPI88797.1 - 4.3e-18 64.0 13.9 0.00019 21.1 0.0 6.7 7 0 0 7 7 7 4 MORN repeat Ribosomal_S15 PF00312.22 KPI88798.1 - 7.9e-07 29.2 1.5 1.9e-06 28.0 1.5 1.6 1 0 0 1 1 1 1 Ribosomal protein S15 CTP_transf_like PF01467.26 KPI88799.1 - 2.5e-05 24.5 0.0 0.00078 19.7 0.0 2.4 2 0 0 2 2 2 1 Cytidylyltransferase-like CinA PF02464.17 KPI88799.1 - 0.0067 16.0 0.1 0.012 15.2 0.1 1.4 1 0 0 1 1 1 1 Competence-damaged protein zinc_ribbon_10 PF10058.9 KPI88800.1 - 0.0061 16.3 0.4 0.0089 15.7 0.4 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_3 PF13878.6 KPI88800.1 - 0.68 9.8 6.1 2.6 8.0 0.4 2.3 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf_UBZ PF18439.1 KPI88800.1 - 2.6 7.7 5.5 14 5.4 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Nudix_N_2 PF14803.6 KPI88801.1 - 0.0017 18.2 0.6 0.66 9.9 0.1 2.4 2 0 0 2 2 2 2 Nudix N-terminal TF_Zn_Ribbon PF08271.12 KPI88801.1 - 0.0042 16.6 1.5 0.15 11.6 0.1 2.3 2 0 0 2 2 2 1 TFIIB zinc-binding A2L_zn_ribbon PF08792.10 KPI88801.1 - 0.006 16.3 0.2 0.013 15.2 0.2 1.5 1 0 0 1 1 1 1 A2L zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 KPI88801.1 - 0.0078 16.1 0.7 2.6 8.1 0.2 2.2 2 0 0 2 2 2 2 PhnA Zinc-Ribbon DNA_RNApol_7kD PF03604.13 KPI88801.1 - 0.011 15.4 1.4 0.023 14.3 1.4 1.6 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DUF2318 PF10080.9 KPI88801.1 - 0.055 13.6 0.1 0.064 13.4 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) PPR_2 PF13041.6 KPI88802.1 - 5.7e-10 39.2 0.0 0.025 14.8 0.0 4.8 3 1 2 5 5 5 3 PPR repeat family PPR PF01535.20 KPI88802.1 - 2.6e-07 30.4 0.0 0.17 12.2 0.0 3.8 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.6 KPI88802.1 - 0.00019 21.4 0.0 0.015 15.4 0.0 2.9 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_long PF17177.4 KPI88802.1 - 0.052 12.9 0.4 0.35 10.2 0.2 2.1 1 1 2 3 3 3 0 Pentacotripeptide-repeat region of PRORP Tubulin PF00091.25 KPI88803.1 - 9.8e-28 97.7 0.1 1.2e-14 55.0 0.0 3.0 2 1 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain TM231 PF10149.9 KPI88804.1 - 8.9e-24 84.4 4.1 4.7e-13 49.1 0.0 2.7 2 1 0 2 2 2 2 Transmembrane protein 231 Ribosomal_S6e PF01092.19 KPI88805.1 - 5.4e-40 136.3 0.0 1.1e-39 135.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e RmlD_sub_bind PF04321.17 KPI88806.1 - 0.0042 16.2 0.0 1.1 8.3 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain EF-hand_6 PF13405.6 KPI88807.1 - 2.2e-10 39.6 0.1 0.011 15.6 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KPI88807.1 - 3.3e-09 35.6 0.0 0.0086 15.6 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 KPI88807.1 - 8.3e-07 28.2 0.1 0.017 14.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KPI88807.1 - 1.3e-05 25.5 0.0 0.26 11.8 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair Ank_2 PF12796.7 KPI88808.1 - 2.4e-56 188.3 29.2 1e-11 45.3 0.6 16.0 11 3 6 17 17 17 12 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI88808.1 - 1e-35 121.3 37.7 2.4e-08 34.1 0.3 16.7 13 4 5 18 18 18 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI88808.1 - 6.7e-32 105.9 37.2 0.00042 20.5 0.1 19.9 21 0 0 21 21 21 8 Ankyrin repeat Ank_4 PF13637.6 KPI88808.1 - 2.2e-31 107.8 30.0 2.1e-06 28.2 0.0 16.9 13 5 4 17 17 17 9 Ankyrin repeats (many copies) Ank PF00023.30 KPI88808.1 - 5.5e-25 86.7 50.5 0.00025 21.4 0.2 18.9 18 3 1 19 19 19 7 Ankyrin repeat Filamin PF00630.19 KPI88808.1 - 0.01 16.7 0.0 0.066 14.0 0.0 2.2 2 0 0 2 2 2 1 Filamin/ABP280 repeat Clathrin_H_link PF13838.6 KPI88808.1 - 0.023 14.6 0.0 0.072 13.0 0.0 1.8 1 0 0 1 1 1 0 Clathrin-H-link DdrB PF12747.7 KPI88808.1 - 0.21 11.4 0.0 0.47 10.3 0.0 1.5 1 0 0 1 1 1 0 DdrB-like protein Ribosomal_L32e PF01655.18 KPI88809.1 - 4e-40 136.6 0.2 4.8e-40 136.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 CdiI PF07262.11 KPI88809.1 - 0.15 11.8 0.3 0.25 11.1 0.1 1.5 2 0 0 2 2 2 0 CDI immunity protein SH3_9 PF14604.6 KPI88810.1 - 4.2e-30 103.4 1.8 7.2e-11 41.8 0.0 4.5 5 0 0 5 5 5 3 Variant SH3 domain SH3_1 PF00018.28 KPI88810.1 - 1.9e-27 94.6 0.2 1.1e-10 40.9 0.0 3.8 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.17 KPI88810.1 - 3.6e-22 77.8 0.1 4.1e-09 36.0 0.2 4.1 3 1 0 3 3 3 3 Variant SH3 domain DUF4205 PF13898.6 KPI88811.1 - 1.9e-23 83.0 0.0 7.7e-23 81.0 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4205) DUF4710 PF15828.5 KPI88811.1 - 0.28 11.3 3.5 0.63 10.2 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) SRP-alpha_N PF04086.13 KPI88811.1 - 4.7 7.1 7.5 7.8 6.3 7.5 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal E1-E2_ATPase PF00122.20 KPI88812.1 - 7.5e-42 142.9 1.5 7.5e-42 142.9 1.5 2.0 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KPI88812.1 - 1.4e-27 96.6 4.4 1.4e-27 96.6 4.4 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KPI88812.1 - 6.8e-16 59.2 0.0 1e-14 55.3 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KPI88812.1 - 1.5e-14 53.8 0.0 3.1e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KPI88812.1 - 2.1e-10 40.1 0.0 5.3e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KPI88812.1 - 5.9e-06 26.2 0.2 1.3e-05 25.1 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PIG-F PF06699.11 KPI88812.1 - 0.035 14.3 2.8 0.18 12.0 0.3 2.4 2 0 0 2 2 2 0 GPI biosynthesis protein family Pig-F Kinesin PF00225.23 KPI88813.1 - 3e-71 240.1 2.3 5.6e-42 143.8 0.0 2.7 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 KPI88813.1 - 3.4e-21 75.7 0.0 1e-20 74.2 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding OrfB_IS605 PF01385.19 KPI88813.1 - 0.057 13.6 0.5 0.21 11.8 0.5 1.9 1 0 0 1 1 1 0 Probable transposase DUF1495 PF07381.11 KPI88813.1 - 0.06 13.2 1.3 0.84 9.5 0.1 3.0 3 1 0 3 3 3 0 Winged helix DNA-binding domain (DUF1495) DUF896 PF05979.12 KPI88813.1 - 7.5 6.5 8.1 1.1 9.2 0.2 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) FERM_M PF00373.18 KPI88813.1 - 8.4 6.8 10.6 4.4 7.7 5.2 2.6 1 1 1 2 2 2 0 FERM central domain Glyco_hydro_3_C PF01915.22 KPI88815.1 - 4.6e-54 183.5 0.0 7.4e-54 182.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KPI88815.1 - 4.7e-50 170.8 0.0 8.3e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KPI88815.1 - 1.6e-28 98.6 0.2 5.3e-28 96.9 0.2 2.0 1 0 0 1 1 1 1 Fibronectin type III-like domain zf-RING_2 PF13639.6 KPI88819.1 - 0.00047 20.4 4.3 0.0015 18.8 4.3 2.0 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.5 KPI88819.1 - 0.001 18.7 5.3 0.0027 17.3 5.3 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 KPI88819.1 - 0.006 16.4 3.3 0.02 14.7 3.3 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI88819.1 - 0.43 10.6 8.4 1.5 8.8 8.4 2.0 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KPI88819.1 - 1.8 8.5 7.3 0.28 11.1 2.3 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) LSM_int_assoc PF16605.5 KPI88819.1 - 2.7 8.2 8.0 0.24 11.5 1.9 2.6 2 0 0 2 2 2 0 LSM-interacting associated unstructured zf-ANAPC11 PF12861.7 KPI88819.1 - 4.2 7.5 6.4 11 6.1 6.4 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 KPI88819.1 - 8.7 6.6 8.2 7.5 6.8 4.7 2.5 1 1 1 2 2 2 0 Zinc-ribbon like family AAA PF00004.29 KPI88820.1 - 0.0062 17.0 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KPI88820.1 - 0.03 13.4 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 KPI88820.1 - 0.055 13.7 0.0 0.22 11.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KPI88820.1 - 0.4 11.0 2.9 0.87 10.0 0.1 3.1 3 0 0 3 3 3 0 AAA ATPase domain MORN PF02493.20 KPI88821.1 - 2.4e-11 42.8 10.5 0.01 15.7 0.1 4.6 4 0 0 4 4 4 4 MORN repeat PI3_PI4_kinase PF00454.27 KPI88823.1 - 1.9e-47 162.2 0.0 3.8e-47 161.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 KPI88823.1 - 3e-28 99.0 2.0 7.1e-28 97.8 2.0 1.7 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 KPI88823.1 - 1.2e-07 31.4 0.0 2.7e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 FATC domain TFCD_C PF12612.8 KPI88823.1 - 0.00089 19.1 3.8 0.0013 18.6 0.7 3.0 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal TIP120 PF08623.10 KPI88823.1 - 0.013 15.3 0.3 5.4 6.8 0.0 3.0 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Ku_PK_bind PF08785.11 KPI88823.1 - 0.033 14.3 0.1 6.3 7.0 0.0 3.4 2 0 0 2 2 2 0 Ku C terminal domain like HEAT PF02985.22 KPI88823.1 - 0.044 14.1 4.0 38 4.9 0.0 6.5 7 0 0 7 7 7 0 HEAT repeat Spt20 PF12090.8 KPI88823.1 - 0.46 10.1 10.5 1.4 8.5 10.5 1.8 1 0 0 1 1 1 0 Spt20 family DnaJ PF00226.31 KPI88824.1 - 7.6e-18 64.4 2.6 8.6e-18 64.2 0.3 2.3 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 KPI88824.1 - 3.3e-08 33.6 0.8 0.00039 20.6 0.2 4.1 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KPI88824.1 - 0.00015 22.0 1.6 0.034 14.4 0.5 3.4 3 0 0 3 3 3 1 Myb-like DNA-binding domain eIF-3_zeta PF05091.12 KPI88824.1 - 0.011 14.7 9.8 0.025 13.6 9.8 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) YIF1 PF03878.15 KPI88825.1 - 9.6e-45 153.0 0.0 1.6e-44 152.2 0.0 1.3 1 1 0 1 1 1 1 YIF1 PRP38 PF03371.15 KPI88826.1 - 3.1e-13 50.0 0.0 4.5e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 PRP38 family LapA_dom PF06305.11 KPI88827.1 - 0.1 12.4 0.0 0.1 12.4 0.0 3.3 5 0 0 5 5 5 0 Lipopolysaccharide assembly protein A domain Esterase PF00756.20 KPI88828.1 - 1.2e-19 71.0 0.0 4.3e-19 69.2 0.0 1.8 1 1 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 KPI88828.1 - 0.0025 17.3 0.2 0.0071 15.9 0.2 1.8 1 1 0 1 1 1 1 Esterase PHB depolymerase AMPK1_CBM PF16561.5 KPI88828.1 - 0.0028 17.8 0.0 0.0074 16.5 0.0 1.7 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Esterase PF00756.20 KPI88829.1 - 1.4e-08 34.7 0.0 2e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Abhydro_lipase PF04083.16 KPI88829.1 - 0.0077 15.8 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region AAA PF00004.29 KPI88830.1 - 3.7e-31 108.3 0.0 1.6e-28 99.7 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI88830.1 - 1.2e-12 48.5 4.1 3.3e-07 30.8 0.1 4.0 3 1 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 KPI88830.1 - 9e-12 45.4 0.1 0.00014 22.2 0.0 3.0 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KPI88830.1 - 2.6e-07 30.5 0.0 0.00024 20.9 0.0 2.6 2 1 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.6 KPI88830.1 - 8.2e-07 29.3 0.0 0.002 18.3 0.0 2.8 2 1 0 2 2 2 2 AAA domain TniB PF05621.11 KPI88830.1 - 3.3e-06 26.7 0.0 0.0037 16.7 0.0 2.9 3 0 0 3 3 3 1 Bacterial TniB protein AAA_5 PF07728.14 KPI88830.1 - 8.8e-06 25.8 0.0 5.3e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KPI88830.1 - 4.4e-05 23.8 0.0 0.0093 16.3 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 KPI88830.1 - 6.4e-05 23.0 0.0 0.00033 20.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KPI88830.1 - 7.3e-05 22.6 0.0 0.00021 21.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KPI88830.1 - 0.00012 21.5 0.1 0.0023 17.4 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KPI88830.1 - 0.00019 21.4 0.1 0.066 13.1 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_7 PF12775.7 KPI88830.1 - 0.00023 20.8 0.0 0.024 14.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 KPI88830.1 - 0.00043 19.5 0.0 0.023 13.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 KPI88830.1 - 0.00068 19.4 0.0 0.0068 16.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KPI88830.1 - 0.0015 18.2 0.0 1.3 8.8 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain TsaE PF02367.17 KPI88830.1 - 0.0017 18.4 0.0 0.14 12.1 0.1 2.6 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 KPI88830.1 - 0.0017 18.0 0.1 0.03 13.9 0.0 3.0 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.6 KPI88830.1 - 0.0024 18.2 0.5 0.25 11.6 0.0 3.2 4 0 0 4 4 3 1 AAA domain MCM PF00493.23 KPI88830.1 - 0.0025 17.0 0.0 0.043 12.9 0.0 2.1 2 0 0 2 2 2 1 MCM P-loop domain ATPase_2 PF01637.18 KPI88830.1 - 0.0025 17.7 0.0 1.1 9.1 0.0 3.1 2 1 0 3 3 3 1 ATPase domain predominantly from Archaea TIP49 PF06068.13 KPI88830.1 - 0.0033 16.7 0.0 0.006 15.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 KPI88830.1 - 0.0052 17.3 0.0 0.046 14.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KPI88830.1 - 0.006 15.7 0.0 0.98 8.4 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_2 PF07724.14 KPI88830.1 - 0.0081 16.3 0.0 0.044 13.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 KPI88830.1 - 0.01 15.5 0.0 0.18 11.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 KPI88830.1 - 0.015 15.8 0.0 0.1 13.1 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_11 PF13086.6 KPI88830.1 - 0.018 14.9 0.0 0.45 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KPI88830.1 - 0.025 14.4 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 KPI88830.1 - 0.037 13.1 0.0 0.1 11.7 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 KPI88830.1 - 0.059 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Roc PF08477.13 KPI88830.1 - 0.11 12.7 0.0 5.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 KPI88830.1 - 0.14 11.4 0.0 0.94 8.7 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin H_lectin PF09458.10 KPI88832.1 - 0.042 14.0 0.4 1.3 9.3 0.1 2.5 2 0 0 2 2 2 0 H-type lectin domain IMS PF00817.20 KPI88833.1 - 4.8e-37 127.3 0.0 9.1e-37 126.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.8 KPI88833.1 - 6.2e-07 29.4 0.0 1.2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 IMS family HHH motif DUF1179 PF06678.11 KPI88833.1 - 0.0042 17.1 0.1 0.01 15.8 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1179) Cdd1 PF11731.8 KPI88833.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Pathogenicity locus IMS PF00817.20 KPI88834.1 - 1.6e-38 132.0 0.0 3.2e-38 131.1 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KPI88834.1 - 5.7e-11 43.1 0.0 1.3e-10 42.0 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Mei5 PF10376.9 KPI88834.1 - 6.2e-05 22.9 4.7 0.00012 22.1 4.7 1.4 1 0 0 1 1 1 1 Double-strand recombination repair protein Caps_synth_GfcC PF06251.11 KPI88834.1 - 0.0026 17.4 0.4 0.0056 16.3 0.4 1.4 1 0 0 1 1 1 1 Capsule biosynthesis GfcC IMS_HHH PF11798.8 KPI88834.1 - 0.0047 17.2 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Pox_A_type_inc PF04508.12 KPI88834.1 - 0.0066 16.3 0.2 0.017 15.0 0.2 1.7 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat Exonuc_VII_L PF02601.15 KPI88834.1 - 1.2 8.6 9.3 2.1 7.9 9.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit IMS PF00817.20 KPI88836.1 - 3.8e-34 117.8 0.0 1.2e-33 116.2 0.0 1.9 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 KPI88836.1 - 2.6e-13 50.7 0.2 5.3e-13 49.7 0.2 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 KPI88836.1 - 0.00025 21.2 0.0 0.00057 20.1 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Phe_hydrox_dim PF07976.12 KPI88836.1 - 0.022 14.8 0.9 0.044 13.8 0.5 1.7 2 0 0 2 2 2 0 Phenol hydroxylase, C-terminal dimerisation domain zf-CCCH_4 PF18044.1 KPI88837.1 - 4.6e-06 26.3 6.6 1.3e-05 24.8 6.6 1.9 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI88837.1 - 0.00027 20.9 6.8 0.00027 20.9 6.8 2.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 KPI88837.1 - 0.00038 20.3 4.6 0.00038 20.3 4.6 2.3 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KPI88837.1 - 0.0011 19.7 0.5 0.0019 18.9 0.5 1.4 1 0 0 1 1 1 1 Torus domain zf-CCCH_2 PF14608.6 KPI88837.1 - 0.0094 16.4 8.9 0.01 16.3 7.0 2.1 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger Tachystatin_A PF11406.8 KPI88837.1 - 0.38 10.9 0.2 0.38 10.9 0.2 2.7 3 0 0 3 3 3 0 Antimicrobial peptide tachystatin A Amastin PF07344.11 KPI88838.1 - 7.8e-32 110.3 11.4 1.1e-31 109.7 11.4 1.2 1 0 0 1 1 1 1 Amastin surface glycoprotein PEN-2 PF10251.9 KPI88838.1 - 0.00039 20.8 0.6 0.0042 17.5 0.1 2.5 2 0 0 2 2 2 1 Presenilin enhancer-2 subunit of gamma secretase Amastin PF07344.11 KPI88839.1 - 4.9e-43 146.7 2.3 6.8e-43 146.2 2.3 1.2 1 0 0 1 1 1 1 Amastin surface glycoprotein Hydrolase_3 PF08282.12 KPI88840.1 - 3.2e-38 131.9 0.0 1.2e-20 74.3 0.0 3.4 3 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88840.1 - 4.3e-13 49.4 0.0 3e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88840.1 - 0.00015 22.1 0.1 0.44 10.8 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88840.1 - 0.0032 17.9 0.1 0.12 12.8 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KPI88841.1 - 6.7e-48 163.6 0.0 4.7e-32 111.7 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88841.1 - 4.2e-16 59.2 0.0 8.5e-10 38.6 0.0 2.4 3 0 0 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88841.1 - 7.6e-11 42.7 0.0 2.6e-05 24.6 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88841.1 - 0.00015 22.3 0.1 0.15 12.4 0.0 2.8 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KPI88841.1 - 0.0084 16.2 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KPI88841.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KPI88842.1 - 1.1e-54 185.9 0.0 1.2e-54 185.7 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88842.1 - 4.7e-16 59.1 0.0 3.6e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88842.1 - 2.2e-10 41.2 0.0 0.00031 21.1 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KPI88842.1 - 0.0071 16.4 0.1 4.4 7.3 0.0 3.1 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88842.1 - 0.0072 16.7 0.0 7.6 6.9 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KPI88842.1 - 0.018 15.1 0.0 0.088 12.9 0.0 2.2 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Bmp PF02608.14 KPI88842.1 - 0.086 11.8 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like Hydrolase_3 PF08282.12 KPI88843.1 - 1e-53 182.7 0.0 1.7e-53 182.0 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88843.1 - 5.6e-16 58.8 0.0 4.1e-08 33.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88843.1 - 1.6e-09 38.4 0.1 3.7e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88843.1 - 1.7e-05 25.3 0.3 0.0062 17.0 0.0 3.0 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KPI88843.1 - 0.00047 20.3 0.1 0.054 13.6 0.1 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KPI88843.1 - 0.04 14.0 0.0 0.09 12.9 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KPI88844.1 - 3.9e-48 164.4 0.0 5.1e-48 164.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88844.1 - 3.6e-19 69.3 0.0 1.6e-09 37.7 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88844.1 - 2.4e-09 37.8 0.0 4.3e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88844.1 - 4.8e-05 23.8 0.3 0.017 15.6 0.0 3.1 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KPI88844.1 - 0.005 16.9 0.0 0.15 12.1 0.0 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KPI88844.1 - 0.013 15.5 0.0 0.051 13.7 0.0 2.0 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KPI88845.1 - 5.8e-37 127.8 0.0 1.3e-35 123.4 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88845.1 - 8.9e-09 35.2 0.0 2.6e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88845.1 - 0.00076 19.8 0.1 0.5 10.6 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase CAAX_1 PF15895.5 KPI88845.1 - 0.091 12.7 0.1 0.53 10.2 0.2 1.9 2 0 0 2 2 2 0 CAAX box cerebral protein 1 HAD PF12710.7 KPI88845.1 - 0.22 11.9 0.2 86 3.4 0.0 3.2 3 1 1 4 4 4 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KPI88846.1 - 2.3e-43 148.8 0.0 3e-42 145.1 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88846.1 - 7.5e-12 45.3 0.1 1.5e-05 24.6 0.0 3.0 3 0 0 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88846.1 - 2.4e-05 24.8 0.0 0.007 16.7 0.0 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88846.1 - 0.049 14.0 0.3 10 6.4 0.0 2.9 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KPI88847.1 - 3.7e-45 154.7 0.0 5.6e-45 154.1 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KPI88847.1 - 2.6e-15 56.7 0.0 2.5e-07 30.5 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 KPI88847.1 - 1.1e-06 29.1 1.0 0.0004 20.7 1.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI88847.1 - 0.01 16.2 0.1 4.8 7.5 0.0 2.6 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KPI88847.1 - 0.051 13.7 0.0 0.7 10.0 0.0 2.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase SAMP PF05924.11 KPI88847.1 - 0.089 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 SAMP Motif UbiA PF01040.18 KPI88848.1 - 2.2e-38 132.0 22.0 2.2e-38 132.0 22.0 1.6 1 1 0 1 1 1 1 UbiA prenyltransferase family DEAD PF00270.29 KPI88849.1 - 1.5e-41 142.1 0.0 3e-41 141.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88849.1 - 6.2e-25 87.7 0.0 2.7e-24 85.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KPI88849.1 - 5.8e-12 45.7 0.1 1.6e-11 44.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KPI88849.1 - 2e-08 34.4 0.1 2.4e-07 30.9 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CCDC92 PF14916.6 KPI88849.1 - 0.0082 15.9 0.1 0.1 12.3 0.2 2.6 2 0 0 2 2 2 1 Coiled-coil domain of unknown function DUF2753 PF10952.8 KPI88849.1 - 0.017 15.3 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) HGD-D PF06050.13 KPI88849.1 - 0.078 12.7 0.3 0.13 12.0 0.3 1.3 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component zf-C3HC4_2 PF13923.6 KPI88850.1 - 2.4e-07 30.5 6.4 4.2e-07 29.7 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI88850.1 - 1.1e-06 28.5 4.0 1.7e-06 27.9 4.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KPI88850.1 - 6e-06 26.0 4.2 1e-05 25.3 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KPI88850.1 - 6.5e-06 25.9 2.7 1.1e-05 25.2 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI88850.1 - 4.5e-05 23.7 6.0 7.8e-05 22.9 6.0 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KPI88850.1 - 0.00012 21.9 4.6 0.0002 21.1 4.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KPI88850.1 - 0.0004 20.5 9.8 0.00071 19.7 9.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KPI88850.1 - 0.00064 19.7 8.6 0.0012 18.8 8.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Seryl_tRNA_N PF02403.22 KPI88850.1 - 0.0028 17.9 5.3 0.0028 17.9 5.3 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain zf-RING_4 PF14570.6 KPI88850.1 - 0.037 13.8 2.3 0.077 12.8 2.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DZR PF12773.7 KPI88850.1 - 0.048 13.7 5.3 0.18 11.8 5.3 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_6 PF14835.6 KPI88850.1 - 0.086 12.7 3.8 0.21 11.5 3.8 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein DUF2015 PF09435.10 KPI88850.1 - 0.092 12.6 0.5 18 5.3 0.4 2.5 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2015) HrpB7 PF09486.10 KPI88850.1 - 0.17 12.3 7.2 0.19 12.1 3.3 2.5 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Baculo_IE-1 PF05290.11 KPI88850.1 - 0.17 11.8 6.1 0.13 12.2 0.6 2.4 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) AAA_11 PF13086.6 KPI88850.1 - 0.37 10.6 3.3 0.65 9.7 3.3 1.4 1 0 0 1 1 1 0 AAA domain TF_Zn_Ribbon PF08271.12 KPI88850.1 - 0.44 10.1 4.5 1.9 8.1 0.5 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding FapA PF03961.13 KPI88850.1 - 0.51 8.9 7.3 0.13 10.9 4.3 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A zf-rbx1 PF12678.7 KPI88850.1 - 0.54 10.6 2.8 1.3 9.4 2.8 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Rubredoxin PF00301.20 KPI88850.1 - 0.76 9.8 3.0 11 6.1 3.0 2.2 1 1 0 1 1 1 0 Rubredoxin CENP-F_leu_zip PF10473.9 KPI88850.1 - 1 9.4 26.8 1.4 8.9 15.3 3.2 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 KPI88850.1 - 2 7.7 6.7 0.41 9.9 2.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 KPI88850.1 - 2.9 6.7 15.6 0.041 12.8 7.1 2.1 3 0 0 3 3 3 0 Spc7 kinetochore protein Cep57_MT_bd PF06657.13 KPI88850.1 - 4.6 7.8 15.3 1.9 9.0 9.7 2.9 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 zf-HIT PF04438.16 KPI88850.1 - 6.1 6.8 6.9 8.6 6.3 2.8 2.3 2 1 0 2 2 2 0 HIT zinc finger Perilipin PF03036.16 KPI88851.1 - 0.066 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Perilipin family Biopterin_H PF00351.21 KPI88852.1 - 2.1e-128 428.0 0.0 2.6e-128 427.7 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase WAC_Acf1_DNA_bd PF10537.9 KPI88852.1 - 0.0053 17.3 0.4 0.017 15.6 0.5 1.8 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal ACT PF01842.25 KPI88852.1 - 0.087 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 ACT domain DnaJ PF00226.31 KPI88853.1 - 9.2e-17 60.9 0.5 1.6e-16 60.1 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain BILBO1_N PF18281.1 KPI88856.1 - 1e-29 102.8 0.1 2.4e-29 101.6 0.1 1.6 1 0 0 1 1 1 1 BILBO1 N-terminal domain Occludin_ELL PF07303.13 KPI88856.1 - 0.082 13.6 3.2 0.22 12.3 3.2 1.7 1 0 0 1 1 1 0 Occludin homology domain Exonuc_VII_L PF02601.15 KPI88856.1 - 0.81 9.2 6.9 1.3 8.6 6.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAD_binding_1 PF00667.20 KPI88857.1 - 5.2e-39 134.1 0.0 8.6e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KPI88857.1 - 7.5e-33 113.7 0.7 1.6e-32 112.7 0.2 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 KPI88857.1 - 2.2e-14 54.0 0.0 1.1e-13 51.8 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain TetR_C_7 PF14246.6 KPI88857.1 - 0.06 13.4 0.0 0.83 9.7 0.0 2.4 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain FAD_binding_6 PF00970.24 KPI88857.1 - 0.066 13.6 0.0 0.6 10.5 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain SGL PF08450.12 KPI88858.1 - 4.6e-44 150.8 0.1 1.6e-43 149.1 0.1 1.9 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region WWE PF02825.20 KPI88859.1 - 0.00027 21.5 0.0 0.00064 20.3 0.0 1.7 1 0 0 1 1 1 1 WWE domain HSP70 PF00012.20 KPI88861.1 - 7.9e-252 836.8 15.7 9.1e-252 836.6 15.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KPI88861.1 - 1.3e-20 73.5 1.1 6.6e-18 64.6 0.1 2.3 1 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KPI88861.1 - 0.00022 21.0 0.0 0.00069 19.4 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 KPI88861.1 - 0.0058 15.9 1.7 0.043 13.1 0.1 2.9 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase DUF357 PF04010.13 KPI88861.1 - 0.057 13.5 0.4 7.6 6.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF357) DUF2706 PF10913.8 KPI88861.1 - 0.2 11.5 0.3 7.9 6.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2706) DUF1542 PF07564.11 KPI88861.1 - 0.6 10.3 9.7 0.06 13.5 1.8 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) DUF4795 PF16043.5 KPI88861.1 - 1.5 8.4 7.6 0.19 11.3 2.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Copine PF07002.16 KPI88862.1 - 1.1e-66 224.4 0.0 1.5e-66 224.0 0.0 1.1 1 0 0 1 1 1 1 Copine C2 PF00168.30 KPI88862.1 - 6.5e-29 100.3 0.0 1.5e-14 54.1 0.1 2.2 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 KPI88862.1 - 8.5e-05 22.8 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 KPI88862.1 - 0.0031 17.8 0.0 0.0051 17.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-AN1 PF01428.16 KPI88864.1 - 2.8e-08 33.8 4.2 4.6e-08 33.1 4.2 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger LRR_8 PF13855.6 KPI88865.1 - 0.0032 17.2 0.8 31 4.4 0.0 4.6 5 0 0 5 5 5 2 Leucine rich repeat LRR_6 PF13516.6 KPI88865.1 - 0.0076 16.2 3.3 20 5.6 0.0 5.9 6 0 0 6 6 6 1 Leucine Rich repeat ATP-synt_C PF00137.21 KPI88866.1 - 5.6e-25 87.5 41.1 7.1e-19 67.9 13.2 2.7 3 0 0 3 3 3 2 ATP synthase subunit C RasGEF_N PF00618.20 KPI88867.1 - 1.5e-06 28.4 0.0 0.00015 21.9 0.0 2.6 2 0 0 2 2 2 2 RasGEF N-terminal motif Mononeg_RNA_pol PF00946.19 KPI88867.1 - 0.071 10.7 0.2 0.1 10.2 0.2 1.1 1 0 0 1 1 1 0 Mononegavirales RNA dependent RNA polymerase Arginase PF00491.21 KPI88868.1 - 9.2e-14 51.6 0.0 1.7e-12 47.5 0.0 2.0 2 0 0 2 2 2 2 Arginase family QCR10 PF09796.9 KPI88870.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) ABC_membrane PF00664.23 KPI88871.1 - 2.8e-94 315.8 26.2 7.9e-52 176.6 11.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KPI88871.1 - 6.8e-68 227.4 0.1 5.6e-36 124.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KPI88871.1 - 8.7e-11 41.7 0.3 0.00027 20.5 0.0 3.6 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 KPI88871.1 - 4.7e-07 29.3 0.1 0.00044 19.6 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 KPI88871.1 - 1.8e-06 27.9 0.0 0.055 13.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KPI88871.1 - 1e-05 25.2 0.4 0.15 11.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 KPI88871.1 - 1.1e-05 24.4 0.1 0.00012 21.0 0.0 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.6 KPI88871.1 - 5.3e-05 23.7 0.1 0.37 11.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KPI88871.1 - 0.00019 21.7 0.8 0.75 10.1 0.0 3.5 2 2 0 2 2 2 2 AAA domain Rad17 PF03215.15 KPI88871.1 - 0.00025 21.0 0.1 0.2 11.6 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_23 PF13476.6 KPI88871.1 - 0.00027 21.5 1.4 0.35 11.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 KPI88871.1 - 0.00035 20.3 0.5 0.31 10.7 0.0 2.8 3 0 0 3 3 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.6 KPI88871.1 - 0.00042 20.1 0.0 0.41 10.3 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 KPI88871.1 - 0.0011 18.5 0.3 0.94 9.0 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 KPI88871.1 - 0.0025 18.2 1.0 5.5 7.4 0.0 4.0 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 KPI88871.1 - 0.0043 16.3 1.2 0.44 9.7 0.0 2.6 3 0 0 3 3 3 1 G-protein alpha subunit Viral_helicase1 PF01443.18 KPI88871.1 - 0.0045 16.7 0.1 2.5 7.8 0.0 3.0 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 KPI88871.1 - 0.0052 17.3 0.1 11 6.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 KPI88871.1 - 0.0097 16.2 0.3 1.2 9.4 0.0 3.2 3 0 0 3 3 2 1 AAA domain MeaB PF03308.16 KPI88871.1 - 0.012 14.6 0.0 3.5 6.5 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SbcCD_C PF13558.6 KPI88871.1 - 0.015 15.5 6.2 8 6.8 0.4 4.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 KPI88871.1 - 0.015 15.7 2.2 9.6 6.7 0.0 3.5 4 0 0 4 4 3 0 RNA helicase SRP54 PF00448.22 KPI88871.1 - 0.017 14.7 0.1 3.8 7.1 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 KPI88871.1 - 0.02 15.0 0.4 6.8 6.7 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_30 PF13604.6 KPI88871.1 - 0.033 13.9 0.1 14 5.4 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.6 KPI88871.1 - 0.035 13.7 0.0 17 5.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 KPI88871.1 - 0.035 14.1 0.1 3.7 7.5 0.0 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 KPI88871.1 - 0.042 13.6 0.5 1.7 8.4 0.1 3.0 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 KPI88871.1 - 0.079 13.0 0.4 23 5.1 0.1 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase Mg_chelatase PF01078.21 KPI88871.1 - 0.086 12.2 0.0 8.2 5.7 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI MoaE PF02391.17 KPI88871.1 - 0.12 12.6 1.3 1.1 9.6 0.0 2.9 4 0 0 4 4 2 0 MoaE protein Fumarate_red_D PF02313.17 KPI88871.1 - 0.18 12.0 3.2 1.4 9.0 3.2 2.6 1 0 0 1 1 1 0 Fumarate reductase subunit D DEAD PF00270.29 KPI88871.1 - 0.32 10.7 2.7 3.2 7.5 0.1 3.1 2 2 0 2 2 2 0 DEAD/DEAH box helicase TM_helix PF05552.12 KPI88871.1 - 2.8 8.0 6.1 0.82 9.7 0.0 2.6 2 0 0 2 2 2 0 Conserved TM helix RTT107_BRCT_5 PF16770.5 KPI88872.1 - 0.01 15.7 1.0 0.078 12.9 0.0 3.0 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain WbqC PF08889.11 KPI88872.1 - 0.2 11.5 5.4 0.26 11.1 0.9 2.7 2 0 0 2 2 2 0 WbqC-like protein family DUF3247 PF11607.8 KPI88872.1 - 2.7 8.3 5.2 1.1 9.6 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3247) DUF2625 PF10946.8 KPI88872.1 - 6.9 5.7 6.5 27 3.7 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function DUF2625 HECT PF00632.25 KPI88873.1 - 3.9e-09 36.4 0.0 0.00036 20.1 0.0 3.2 3 0 0 3 3 3 3 HECT-domain (ubiquitin-transferase) Uso1_p115_C PF04871.13 KPI88874.1 - 0.013 15.8 1.2 0.013 15.8 1.2 1.9 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CLZ PF16526.5 KPI88874.1 - 0.022 15.1 0.5 0.066 13.6 0.5 1.8 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ubiquitin PF00240.23 KPI88874.1 - 0.086 12.6 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin family Cep57_MT_bd PF06657.13 KPI88874.1 - 0.11 12.9 0.9 6.7 7.2 0.3 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 KELK PF15796.5 KPI88874.1 - 0.12 12.9 0.3 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Lebercilin PF15619.6 KPI88874.1 - 0.19 11.4 1.0 0.34 10.5 1.0 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease zf-C4H2 PF10146.9 KPI88874.1 - 0.35 11.2 4.2 0.47 10.7 2.7 1.9 2 0 0 2 2 2 0 Zinc finger-containing protein CDK2AP PF09806.9 KPI88874.1 - 1.9 8.5 6.6 0.73 9.9 0.2 2.5 3 0 0 3 3 3 0 Cyclin-dependent kinase 2-associated protein zf-CSL PF05207.13 KPI88875.1 - 5.8e-15 54.8 0.2 8.2e-15 54.3 0.2 1.2 1 0 0 1 1 1 1 CSL zinc finger FAD_binding_3 PF01494.19 KPI88877.1 - 1.5e-12 47.4 0.1 3.1e-11 43.1 0.0 2.6 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 KPI88877.1 - 3.1e-06 27.3 0.1 1.6e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KPI88877.1 - 3.3e-05 23.2 0.1 0.0002 20.6 0.0 2.2 2 1 0 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.14 KPI88877.1 - 9e-05 21.8 0.0 0.0015 17.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KPI88877.1 - 0.0002 21.0 0.1 0.0016 18.1 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KPI88877.1 - 0.00025 21.5 0.0 0.0007 20.1 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KPI88877.1 - 0.0081 15.2 0.0 0.031 13.3 0.0 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 KPI88877.1 - 0.071 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KPI88877.1 - 0.11 11.8 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Mod_r PF07200.13 KPI88878.1 - 0.1 12.7 14.6 1.1 9.4 1.8 2.7 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2982 PF11201.8 KPI88878.1 - 0.16 11.5 0.5 0.48 10.0 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2982) Spc7 PF08317.11 KPI88878.1 - 0.29 10.0 10.3 0.041 12.7 3.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 KPI88878.1 - 0.37 11.0 6.3 0.55 10.5 3.6 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.11 KPI88878.1 - 0.55 10.8 5.9 0.88 10.2 0.9 3.2 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Lebercilin PF15619.6 KPI88878.1 - 0.69 9.6 15.3 0.062 13.0 7.0 2.4 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Golgin_A5 PF09787.9 KPI88878.1 - 2.1 7.7 10.8 0.73 9.2 0.8 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 5 KASH_CCD PF14662.6 KPI88878.1 - 4 7.2 11.5 0.44 10.3 2.4 2.6 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH PqiA PF04403.13 KPI88879.1 - 1.6e-13 50.7 26.2 8.8e-12 45.1 7.6 2.6 2 1 0 2 2 2 2 Paraquat-inducible protein A Herpes_UL42 PF02282.16 KPI88880.1 - 0.0013 18.6 0.4 0.0017 18.3 0.4 1.1 1 0 0 1 1 1 1 DNA polymerase processivity factor (UL42) Pkinase PF00069.25 KPI88881.1 - 6.8e-46 156.8 0.0 1e-45 156.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88881.1 - 5.5e-29 101.2 0.0 8.1e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI88881.1 - 0.0042 15.9 0.0 0.0057 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI88881.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family SET PF00856.28 KPI88882.1 - 1.3e-13 51.7 0.1 9.5e-12 45.6 0.1 2.4 1 1 0 1 1 1 1 SET domain Dala_Dala_lig_C PF07478.13 KPI88882.1 - 4.8e-11 42.6 0.0 8e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KPI88882.1 - 0.00029 20.5 0.0 0.00045 19.8 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KPI88882.1 - 0.0075 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KPI88882.1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 KPI88882.1 - 0.14 11.8 0.5 0.62 9.6 0.2 2.2 2 1 0 2 2 2 0 ATP-grasp domain Cytochrom_C_asm PF01578.20 KPI88885.1 - 0.21 11.3 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C assembly protein PPR PF01535.20 KPI88886.1 - 0.027 14.7 0.0 2.1 8.8 0.0 3.3 3 0 0 3 3 3 0 PPR repeat Metallophos PF00149.28 KPI88887.1 - 2.9e-32 112.9 0.0 6.5e-32 111.7 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DnaJ PF00226.31 KPI88888.1 - 7.2e-06 26.0 0.0 1.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain ORC6 PF05460.13 KPI88888.1 - 0.28 10.4 23.3 0.36 10.1 3.8 2.2 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) VP_N-CPKC PF11475.8 KPI88888.1 - 7.3 6.6 8.5 24 5.0 0.4 3.4 3 0 0 3 3 3 0 Virion protein N terminal domain Pkinase PF00069.25 KPI88889.1 - 1.1e-46 159.4 0.0 1.3e-46 159.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88889.1 - 2.8e-25 89.1 0.0 4.1e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.21 KPI88889.1 - 3e-05 24.1 25.9 9.2e-05 22.5 25.9 2.0 1 1 0 1 1 1 1 FYVE zinc finger APH PF01636.23 KPI88889.1 - 0.00032 20.7 0.1 0.0029 17.6 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI88889.1 - 0.00075 18.9 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI88889.1 - 0.0027 16.6 0.3 0.0048 15.7 0.2 1.3 1 1 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 KPI88889.1 - 0.0027 17.3 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 RIO1 family zf-C2HC5 PF06221.13 KPI88889.1 - 0.99 9.4 7.4 3.2 7.8 7.4 1.9 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type CHCH PF06747.13 KPI88890.1 - 0.00015 21.8 6.9 0.017 15.2 3.1 2.6 2 1 0 2 2 2 2 CHCH domain MTCP1 PF08991.10 KPI88890.1 - 0.001 19.3 6.8 0.063 13.5 1.0 2.2 2 0 0 2 2 2 2 Mature-T-Cell Proliferation I type CX9C PF16860.5 KPI88890.1 - 0.0077 16.2 6.5 0.02 14.9 2.2 2.4 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UPF0203 PF05254.12 KPI88890.1 - 0.56 10.5 6.4 0.93 9.8 3.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) NDUF_B7 PF05676.13 KPI88890.1 - 1.3 8.8 9.7 0.36 10.6 1.5 2.5 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF3128 PF11326.8 KPI88890.1 - 1.8 9.0 7.9 1.6e+02 2.7 7.9 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) COX6B PF02297.17 KPI88890.1 - 4.1 7.7 10.3 2.8 8.2 4.5 2.3 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb MORN PF02493.20 KPI88891.1 - 1.2e-27 94.1 40.5 4.8e-09 35.6 0.6 9.5 10 0 0 10 10 10 8 MORN repeat PH PF00169.29 KPI88891.1 - 8.8e-06 26.2 0.0 2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 PH domain Jnk-SapK_ap_N PF09744.9 KPI88892.1 - 0.0061 16.8 9.2 0.0061 16.8 9.2 14.2 7 5 6 13 13 13 3 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 KPI88892.1 - 0.0082 16.3 8.2 0.0082 16.3 8.2 11.8 5 4 6 11 11 11 3 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 KPI88892.1 - 0.072 13.6 0.2 0.072 13.6 0.2 14.3 9 2 3 13 13 13 0 Apg6 coiled-coil region CDP-OH_P_transf PF01066.21 KPI88893.1 - 8.8e-12 45.6 3.3 8.8e-12 45.6 3.3 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase MREG PF15812.5 KPI88893.1 - 0.075 13.3 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Melanoregulin Stc1 PF12898.7 KPI88894.1 - 0.1 13.2 4.3 6.2 7.4 3.5 2.7 1 1 0 1 1 1 0 Stc1 domain DUF2630 PF10944.8 KPI88896.1 - 0.063 13.7 0.6 0.063 13.7 0.6 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2630) DUF1517 PF07466.11 KPI88896.1 - 0.089 12.9 1.7 0.14 12.3 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) Pkinase PF00069.25 KPI88897.1 - 4e-38 131.3 0.0 5.3e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88897.1 - 2.9e-25 89.0 0.0 4.3e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI88897.1 - 8.4e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI88897.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family JAB PF01398.21 KPI88898.1 - 6.1e-15 55.2 0.1 1.2e-07 31.8 0.1 2.2 2 0 0 2 2 2 2 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KPI88898.1 - 1.4e-07 31.3 1.1 2.7e-06 27.2 1.1 2.2 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain BTB PF00651.31 KPI88899.1 - 4.8e-11 42.9 0.1 0.00038 20.6 0.1 3.1 2 2 0 2 2 2 2 BTB/POZ domain MATH PF00917.26 KPI88899.1 - 0.00013 22.1 0.0 0.00024 21.2 0.0 1.4 1 0 0 1 1 1 1 MATH domain PARP_reg PF02877.14 KPI88900.1 - 0.0034 17.5 0.2 0.011 15.8 0.2 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Phage_lambda_P PF06992.11 KPI88900.1 - 0.049 13.4 0.5 6.2 6.5 0.0 3.3 2 1 2 4 4 4 0 Replication protein P Spectrin PF00435.21 KPI88900.1 - 1.2 9.6 15.2 0.48 10.9 1.5 3.7 3 1 1 4 4 4 0 Spectrin repeat Tim17 PF02466.19 KPI88901.1 - 1.4e-10 41.5 2.9 5.6e-09 36.4 2.6 2.2 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF1266 PF06889.11 KPI88901.1 - 0.1 12.6 0.9 0.13 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) Mcm10 PF09332.11 KPI88902.1 - 3.2e-08 33.4 3.8 3.2e-08 33.4 3.8 1.8 2 0 0 2 2 2 1 Mcm10 replication factor zf-primase PF09329.11 KPI88902.1 - 3.3e-08 33.2 0.7 7.1e-08 32.1 0.7 1.6 1 0 0 1 1 1 1 Primase zinc finger fn3 PF00041.21 KPI88903.1 - 4.3e-100 328.2 68.8 8.3e-08 32.5 0.2 37.7 41 1 0 41 41 41 26 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KPI88903.1 - 3.2e-33 114.1 59.0 0.048 14.2 0.6 26.6 30 1 0 30 30 30 10 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 KPI88903.1 - 5e-19 68.5 0.6 0.1 12.9 0.3 13.9 17 0 0 17 17 17 3 Interferon-alpha/beta receptor, fibronectin type III fn3_4 PF16794.5 KPI88903.1 - 0.021 14.7 0.0 19 5.2 0.0 5.2 7 0 0 7 7 7 0 Fibronectin-III type domain DUF2012 PF09430.10 KPI88903.1 - 0.17 12.0 0.0 2.9 8.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) HECT PF00632.25 KPI88904.1 - 1.9e-33 116.2 0.0 7.2e-26 91.4 0.0 2.3 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 KPI88904.1 - 1.6e-14 54.1 0.0 2e-10 40.8 0.0 3.1 3 0 0 3 3 3 2 SPRY domain zf-RanBP PF00641.18 KPI88904.1 - 4.2e-07 29.2 14.4 0.0002 20.6 1.8 3.2 1 1 1 2 2 2 2 Zn-finger in Ran binding protein and others Sec1 PF00995.23 KPI88905.1 - 3e-87 294.2 0.0 3.4e-87 294.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family TFIIS_M PF07500.14 KPI88907.1 - 3.4e-08 33.9 0.1 5.4e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Zn_Tnp_IS1595 PF12760.7 KPI88907.1 - 0.088 12.8 2.0 0.16 11.9 2.0 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain TFIIS_C PF01096.18 KPI88907.1 - 0.4 10.6 5.2 1.3 8.9 0.5 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) TFIIS_C PF01096.18 KPI88908.1 - 1e-15 57.3 6.0 1.9e-15 56.4 6.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.14 KPI88908.1 - 6.4e-14 52.4 0.8 1.1e-13 51.6 0.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Baculo_LEF5_C PF11792.8 KPI88908.1 - 0.0024 17.5 1.3 0.0051 16.5 1.3 1.6 1 1 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain zf-DNL PF05180.12 KPI88908.1 - 0.006 16.5 0.6 0.012 15.5 0.6 1.5 1 0 0 1 1 1 1 DNL zinc finger MoCF_biosynth PF00994.24 KPI88908.1 - 0.031 13.9 0.0 0.15 11.7 0.0 1.9 2 0 0 2 2 2 0 Probable molybdopterin binding domain Elf1 PF05129.13 KPI88908.1 - 0.1 12.6 0.5 0.21 11.7 0.5 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like YjeJ PF15922.5 KPI88908.1 - 0.18 11.0 0.9 4.5 6.4 0.0 2.1 1 1 0 2 2 2 0 YjeJ-like zinc_ribbon_4 PF13717.6 KPI88908.1 - 1.3 9.0 4.2 3.5 7.6 0.2 2.7 3 0 0 3 3 3 0 zinc-ribbon domain ubiquitin PF00240.23 KPI88909.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family Pkinase PF00069.25 KPI88910.1 - 1.1e-50 172.5 0.0 3.6e-49 167.5 0.0 2.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88910.1 - 9.3e-26 90.6 0.0 1.5e-21 76.9 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase FHA PF00498.26 KPI88910.1 - 2.9e-14 53.2 0.3 5.4e-14 52.3 0.3 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KPI88910.1 - 6e-08 32.9 0.0 1.5e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 KPI88910.1 - 0.0011 18.3 0.0 2.9 7.1 0.0 3.0 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 KPI88910.1 - 0.0016 18.4 0.1 2 8.3 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 KPI88910.1 - 0.02 14.5 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family CAF1C_H4-bd PF12265.8 KPI88911.1 - 3.6e-09 36.7 0.1 1.3e-08 34.9 0.1 2.1 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 KPI88911.1 - 2.4e-05 24.6 0.6 0.096 13.0 0.1 3.9 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI88911.1 - 0.00025 21.8 11.9 0.49 11.4 0.3 5.6 5 1 0 5 5 5 1 WD domain, G-beta repeat DEAD PF00270.29 KPI88912.1 - 2.2e-34 118.8 1.0 5.1e-34 117.6 0.6 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88912.1 - 6.3e-17 61.9 0.2 2.7e-16 59.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88912.1 - 1.1e-06 28.8 0.0 3.7e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 KPI88912.1 - 8.1e-05 21.5 0.2 0.00018 20.4 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain WD40 PF00400.32 KPI88915.1 - 4.9e-08 33.5 2.1 0.042 14.7 0.1 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat tify PF06200.14 KPI88915.1 - 0.0035 16.6 2.6 1.7 8.0 0.1 2.7 2 0 0 2 2 2 2 tify domain DUF5500 PF17604.2 KPI88915.1 - 0.05 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5500) NIF PF03031.18 KPI88916.1 - 9.6e-32 109.9 0.4 1.3e-31 109.5 0.4 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.26 KPI88916.1 - 0.19 12.0 0.0 1.3 9.2 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase zf-RING_2 PF13639.6 KPI88917.1 - 8.6e-05 22.8 8.0 0.00025 21.3 8.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KPI88917.1 - 0.015 15.6 6.8 0.041 14.2 6.8 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain FANCL_C PF11793.8 KPI88917.1 - 0.029 14.5 4.6 0.075 13.2 4.6 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain SPX PF03105.19 KPI88917.1 - 0.085 12.8 1.5 0.16 11.9 1.5 1.3 1 0 0 1 1 1 0 SPX domain zf-ANAPC11 PF12861.7 KPI88917.1 - 0.2 11.7 4.2 0.44 10.6 4.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 KPI88917.1 - 0.45 10.4 6.5 1.1 9.2 6.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peroxin-3 PF04882.12 KPI88917.1 - 0.63 9.0 10.0 0.99 8.3 0.3 2.4 2 0 0 2 2 2 0 Peroxin-3 zf-C3HC4_3 PF13920.6 KPI88917.1 - 2.2 8.2 4.0 5.4 7.0 4.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 KPI88917.1 - 5.4 7.2 6.3 12 6.1 6.3 1.6 1 0 0 1 1 1 0 RING-variant domain LRR_6 PF13516.6 KPI88919.1 - 1.3e-23 81.0 14.6 0.001 18.9 0.1 11.7 13 0 0 13 13 13 7 Leucine Rich repeat LRR_4 PF12799.7 KPI88919.1 - 2.6e-21 75.3 8.8 0.0053 17.1 0.0 8.3 6 2 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI88919.1 - 3.9e-09 35.8 14.7 10 7.1 0.1 10.8 10 2 1 11 11 11 3 Leucine Rich Repeat LRR_8 PF13855.6 KPI88919.1 - 2.9e-05 23.7 21.5 0.011 15.5 0.6 9.1 5 2 0 7 7 7 2 Leucine rich repeat Fumerase_C PF05683.12 KPI88920.1 - 2.2e-85 285.2 0.0 4e-85 284.3 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 KPI88920.1 - 2.3e-79 266.6 0.0 2.9e-79 266.3 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Rsm22 PF09243.10 KPI88921.1 - 3.7e-29 101.9 1.2 2.1e-16 60.0 0.1 2.8 3 0 0 3 3 3 2 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 KPI88921.1 - 0.0075 16.1 0.1 0.34 10.7 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Phosphodiest PF01663.22 KPI88922.1 - 1.8e-08 34.4 0.0 3.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase HTH_35 PF13693.6 KPI88922.1 - 0.085 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Sulfatase PF00884.23 KPI88922.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Sulfatase FSIP2 PF15783.5 KPI88924.1 - 0.026 12.5 0.2 0.027 12.4 0.2 1.0 1 0 0 1 1 1 0 Fibrous sheath-interacting protein 2 Nuc_sug_transp PF04142.15 KPI88926.1 - 2.6e-57 194.4 14.1 3.9e-53 180.6 11.8 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 KPI88926.1 - 6e-05 22.4 14.8 0.00011 21.5 14.8 1.4 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 KPI88926.1 - 0.022 14.0 11.8 0.036 13.3 11.8 1.4 1 0 0 1 1 1 0 Purine nucleobase transmembrane transport TMEM154 PF15102.6 KPI88926.1 - 0.025 14.5 0.2 5.6 6.9 0.1 2.4 2 0 0 2 2 2 0 TMEM154 protein family DUF3382 PF11862.8 KPI88926.1 - 6.9 7.0 13.1 0.68 10.2 0.8 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF3382) Aminotran_1_2 PF00155.21 KPI88927.1 - 7.7e-65 219.4 0.0 8.9e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Trimer_CC PF08954.11 KPI88928.1 - 0.74 9.4 3.9 19 4.9 0.1 4.1 3 0 0 3 3 3 0 Trimerisation motif MPS2 PF17060.5 KPI88928.1 - 2.4 7.3 5.4 13 5.0 1.3 2.3 2 0 0 2 2 2 0 Monopolar spindle protein 2 SET PF00856.28 KPI88930.1 - 0.047 14.1 0.0 0.099 13.0 0.0 1.6 1 0 0 1 1 1 0 SET domain TPR_14 PF13428.6 KPI88930.1 - 0.18 12.7 1.0 42 5.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RGS12_us1 PF16613.5 KPI88931.1 - 0.11 12.8 0.1 0.24 11.7 0.1 1.5 1 0 0 1 1 1 0 Unstructured region of RGS12 Peptidase_C12 PF01088.21 KPI88932.1 - 1.7e-58 197.8 0.0 2.7e-58 197.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 KPI88932.1 - 3.1e-15 55.8 0.4 7.2e-15 54.6 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases APG6_N PF17675.1 KPI88932.1 - 0.042 14.4 3.1 0.089 13.3 3.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF1505 PF07403.11 KPI88933.1 - 0.1 12.8 0.1 0.32 11.2 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1505) ThiF PF00899.21 KPI88934.1 - 8.8e-32 110.4 0.5 1.1e-31 110.1 0.5 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 KPI88934.1 - 0.018 15.1 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KPI88934.1 - 0.07 13.6 0.3 0.07 13.6 0.3 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Kelch_4 PF13418.6 KPI88936.1 - 1.1e-24 86.2 4.0 2.3e-05 24.3 0.0 6.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KPI88936.1 - 8.8e-21 73.5 3.6 9.3e-07 28.7 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KPI88936.1 - 3.9e-17 61.9 1.0 0.00044 20.4 0.0 6.3 6 1 1 7 7 7 3 Kelch motif Kelch_3 PF13415.6 KPI88936.1 - 9.1e-16 57.7 13.0 0.0071 16.6 0.0 9.3 10 0 0 10 10 10 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KPI88936.1 - 2e-06 27.3 1.4 0.66 9.6 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 KPI88936.1 - 3.9e-06 26.6 0.2 0.21 11.6 0.0 5.3 5 0 0 5 5 5 2 Kelch motif LRR_4 PF12799.7 KPI88937.1 - 1.3e-46 155.8 41.2 1.5e-06 28.5 0.1 14.2 11 3 4 15 15 15 14 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88937.1 - 1.1e-37 127.6 43.2 5.1e-07 29.4 0.6 10.8 7 3 3 11 11 11 10 Leucine rich repeat LRR_9 PF14580.6 KPI88937.1 - 1.4e-31 109.3 19.7 3.2e-07 30.0 0.0 9.0 5 4 3 8 8 8 7 Leucine-rich repeat LRR_6 PF13516.6 KPI88937.1 - 7.1e-06 25.7 26.1 0.19 11.8 0.0 13.6 17 0 0 17 17 17 1 Leucine Rich repeat ADIP PF11559.8 KPI88939.1 - 0.0019 18.3 17.9 0.0019 18.3 17.9 3.3 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding zf-CpG_bind_C PF12269.8 KPI88939.1 - 2.3 8.0 13.2 7.2 6.3 2.4 2.8 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain DnaJ PF00226.31 KPI88940.1 - 1.9e-15 56.7 0.8 3.7e-15 55.8 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain TFIID-31kDa PF02291.15 KPI88940.1 - 0.03 14.4 0.1 0.076 13.1 0.1 1.7 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit BioW PF03744.13 KPI88940.1 - 0.16 11.5 0.0 0.34 10.4 0.0 1.5 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase ENT PF03735.14 KPI88941.1 - 0.0033 17.5 0.0 0.0061 16.6 0.0 1.4 1 0 0 1 1 1 1 ENT domain NeA_P2 PF12312.8 KPI88941.1 - 0.085 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein tRNA-synt_2d PF01409.20 KPI88942.1 - 1.3e-80 270.4 0.5 1.8e-80 270.0 0.5 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 KPI88942.1 - 1.2e-12 47.4 0.4 2.6e-12 46.3 0.4 1.6 1 0 0 1 1 1 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 KPI88942.1 - 5.2e-05 23.4 0.2 0.00091 19.5 0.1 2.7 3 0 0 3 3 3 1 PheRS DNA binding domain 3 MarR_2 PF12802.7 KPI88942.1 - 0.00017 21.4 0.2 0.00088 19.1 0.0 2.3 2 0 0 2 2 2 1 MarR family tRNA_synthFbeta PF17759.1 KPI88942.1 - 0.0021 17.6 0.0 1.7 8.0 0.0 2.9 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 KPI88942.1 - 0.0027 16.8 0.3 0.0027 16.8 0.3 2.0 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 KPI88942.1 - 0.0029 17.6 0.1 0.0084 16.1 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Rrf2 PF02082.20 KPI88942.1 - 0.0088 16.4 0.1 0.02 15.2 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_6 PF01418.17 KPI88942.1 - 0.014 15.3 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HTH_11 PF08279.12 KPI88942.1 - 0.02 14.8 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 HTH domain MarR PF01047.22 KPI88942.1 - 0.038 13.9 0.0 0.087 12.8 0.0 1.6 1 0 0 1 1 1 0 MarR family PheRS_DBD2 PF18554.1 KPI88942.1 - 0.12 12.3 0.2 0.34 10.9 0.2 1.8 1 0 0 1 1 1 0 PheRS DNA binding domain 2 Nif11 PF07862.11 KPI88942.1 - 0.34 11.3 1.3 41 4.6 0.2 2.9 2 0 0 2 2 2 0 Nif11 domain Tmemb_55A PF09788.9 KPI88944.1 - 0.0028 16.8 1.2 0.0028 16.8 1.2 2.2 1 1 1 2 2 2 1 Transmembrane protein 55A RRM_1 PF00076.22 KPI88945.1 - 3.6e-12 45.9 0.0 0.00034 20.4 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KPI88945.1 - 0.00013 22.1 0.0 0.0014 18.8 0.0 2.4 2 0 0 2 2 2 1 RRM-like domain RRM_5 PF13893.6 KPI88945.1 - 0.00036 20.1 0.0 0.021 14.4 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KPI88946.1 - 1.4e-07 31.6 0.0 3.2e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 RRM-like domain RRM_1 PF00076.22 KPI88946.1 - 0.0013 18.5 0.0 0.11 12.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI88946.1 - 0.015 14.9 0.0 4.8 6.8 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3886 PF13025.6 KPI88947.1 - 3.8 7.8 5.6 2.4 8.4 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) Cyclin PF08613.11 KPI88948.1 - 3.6e-22 79.5 0.1 5.9e-22 78.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KPI88948.1 - 3.1e-09 36.7 0.1 4.4e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pkinase PF00069.25 KPI88949.1 - 5.8e-49 166.8 0.0 1e-48 166.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88949.1 - 3e-36 125.0 0.0 5.4e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1356 PF07092.12 KPI88949.1 - 0.07 12.4 0.3 9.9 5.4 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1356) DUF2398 PF09661.10 KPI88950.1 - 0.029 13.6 0.4 0.32 10.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2398) Pkinase PF00069.25 KPI88952.1 - 4.8e-45 154.0 0.0 8.6e-45 153.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI88952.1 - 2.2e-31 109.1 0.0 4e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI88952.1 - 0.0003 20.2 0.0 0.00064 19.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI88952.1 - 0.05 13.5 1.2 0.084 12.8 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI88952.1 - 0.058 12.2 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 KPI88952.1 - 0.21 10.6 0.2 0.54 9.3 0.2 1.6 1 0 0 1 1 1 0 Seadornavirus VP7 RIC1 PF07064.13 KPI88953.1 - 1.4e-40 139.4 0.0 3e-40 138.2 0.0 1.5 2 0 0 2 2 2 1 RIC1 Imm35 PF15567.6 KPI88953.1 - 0.0039 17.3 0.1 0.014 15.6 0.0 2.0 2 0 0 2 2 2 1 Immunity protein 35 ANAPC4_WD40 PF12894.7 KPI88953.1 - 0.0063 16.8 0.0 0.088 13.1 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 KPI88953.1 - 0.13 10.3 0.0 2.8 5.8 0.0 2.1 2 0 0 2 2 2 0 IKI3 family Cyclin_N PF00134.23 KPI88954.1 - 1.4e-08 34.6 1.9 1.2e-07 31.5 0.8 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain RRM_1 PF00076.22 KPI88955.1 - 1.1e-07 31.5 1.5 0.00046 20.0 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI88955.1 - 0.0023 17.5 0.1 0.12 12.0 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2967 PF11179.8 KPI88955.1 - 0.027 12.6 3.4 0.036 12.2 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF1180 PF06679.12 KPI88955.1 - 4.9 7.5 8.0 9.3 6.6 8.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) LRR_4 PF12799.7 KPI88957.1 - 1.1e-12 47.9 6.4 6.8e-05 23.2 0.8 3.9 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88957.1 - 1.6e-09 37.4 9.7 5.8e-07 29.2 3.8 4.4 4 1 0 4 4 4 2 Leucine rich repeat LRR_9 PF14580.6 KPI88957.1 - 0.00096 18.7 0.2 0.39 10.2 0.2 3.0 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 KPI88957.1 - 0.055 14.0 0.6 28 5.8 0.2 4.3 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 KPI88957.1 - 0.24 11.6 2.8 6.5 7.1 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich repeat Pan3_PK PF18101.1 KPI88958.1 - 3.2e-39 134.1 0.4 4.5e-39 133.6 0.4 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain LSM PF01423.22 KPI88959.1 - 2.1e-11 43.4 0.1 2.6e-11 43.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KPI88959.1 - 0.0018 18.3 0.1 0.0024 18.0 0.1 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain Mut7-C PF01927.16 KPI88960.1 - 2.2e-42 144.6 0.9 3.6e-42 143.9 0.9 1.3 1 0 0 1 1 1 1 Mut7-C RNAse domain E6 PF00518.17 KPI88960.1 - 0.082 13.4 2.2 0.37 11.2 2.4 2.2 1 1 0 1 1 1 0 Early Protein (E6) UQ_con PF00179.26 KPI88961.1 - 9.5e-35 119.3 0.0 1.3e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme S4 PF01479.25 KPI88963.1 - 0.00011 21.9 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 S4 domain Kinesin PF00225.23 KPI88964.1 - 1.8e-100 336.1 0.6 1.8e-100 336.1 0.6 3.1 2 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KPI88964.1 - 5.6e-26 91.3 0.0 5.6e-26 91.3 0.0 2.7 3 0 0 3 3 3 1 Microtubule binding DUF3450 PF11932.8 KPI88964.1 - 0.00017 21.0 10.4 0.00017 21.0 10.4 8.6 7 4 4 11 11 11 1 Protein of unknown function (DUF3450) DUF1269 PF06897.12 KPI88964.1 - 0.24 11.7 5.6 0.099 12.9 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1269) DUF2935 PF11155.8 KPI88964.1 - 0.66 10.3 18.2 13 6.1 0.6 6.2 3 2 1 4 4 4 0 Domain of unknown function (DUF2935) AAA_16 PF13191.6 KPI88964.1 - 3 8.2 0.0 3 8.2 0.0 4.6 4 2 1 5 5 5 0 AAA ATPase domain EF-hand_7 PF13499.6 KPI88966.1 - 5e-11 42.9 0.9 0.00073 19.9 0.3 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI88966.1 - 6.6e-10 38.1 0.9 0.0045 16.8 0.1 4.1 3 1 1 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KPI88966.1 - 6.5e-07 29.1 2.2 0.0004 20.2 0.2 3.6 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 KPI88966.1 - 4.1e-06 25.9 1.8 0.033 13.7 0.1 4.0 4 1 0 4 4 4 2 EF hand DUF4924 PF16271.5 KPI88966.1 - 0.063 13.3 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) EF-hand_5 PF13202.6 KPI88966.1 - 0.12 12.0 0.3 0.12 12.0 0.3 3.6 4 0 0 4 4 4 0 EF hand AKAP7_NLS PF10469.9 KPI88967.1 - 1.6e-35 122.9 0.0 2.6e-35 122.2 0.0 1.3 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 KPI88967.1 - 1.5e-06 28.2 0.0 2.9e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily DSPc PF00782.20 KPI88968.1 - 1.8e-12 47.3 0.0 3.4e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI88968.1 - 1.4e-09 37.9 0.0 2.2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KPI88968.1 - 4.4e-05 23.2 0.0 8.1e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 KPI88968.1 - 0.00023 21.3 0.0 0.00046 20.3 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KPI88968.1 - 0.011 15.7 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family AMMECR1 PF01871.17 KPI88969.1 - 1.8e-46 157.8 0.0 2e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 WD40 PF00400.32 KPI88971.1 - 7.9e-10 39.2 3.1 0.00051 20.8 0.2 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KPI88971.1 - 0.018 14.0 0.2 18 4.2 0.0 3.5 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 KPI88971.1 - 0.019 15.2 0.1 7.3 7.0 0.0 3.8 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain MMS1_N PF10433.9 KPI88971.1 - 0.1 11.2 0.0 2.9 6.4 0.0 2.1 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term KxDL PF10241.9 KPI88972.1 - 0.37 11.1 5.3 0.35 11.2 3.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein DnaJ PF00226.31 KPI88973.1 - 5.6e-09 36.0 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain YL1 PF05764.13 KPI88974.1 - 0.061 13.4 14.2 0.013 15.6 9.1 2.2 2 0 0 2 2 2 0 YL1 nuclear protein Afi1 PF07792.12 KPI88974.1 - 0.063 13.8 4.3 0.066 13.7 1.7 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Lin-8 PF03353.15 KPI88974.1 - 4.2 6.9 11.7 0.65 9.5 6.2 1.9 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist RXT2_N PF08595.11 KPI88974.1 - 9.9 6.2 10.8 3.6 7.6 6.7 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal DEAD PF00270.29 KPI88975.1 - 2.6e-34 118.5 0.0 5.7e-34 117.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI88975.1 - 6.9e-28 97.2 0.0 4.6e-27 94.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI88975.1 - 2.9e-06 27.4 0.1 8.1e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KPI88975.1 - 0.65 9.3 0.0 0.65 9.3 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit MTCP1 PF08991.10 KPI88976.1 - 0.00022 21.4 4.7 0.002 18.3 0.7 2.3 2 1 0 2 2 2 1 Mature-T-Cell Proliferation I type UPF0203 PF05254.12 KPI88976.1 - 0.0023 18.1 12.6 1.6 9.0 0.0 3.0 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0203) GCK PF07802.11 KPI88976.1 - 0.011 16.1 1.1 0.011 16.1 1.1 2.6 1 1 2 3 3 3 0 GCK domain Cmc1 PF08583.10 KPI88976.1 - 0.03 14.3 8.3 0.22 11.6 0.3 2.6 2 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 KPI88976.1 - 0.083 12.9 1.3 9.8 6.3 0.2 2.6 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 KPI88976.1 - 0.11 12.8 6.7 0.12 12.7 0.3 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Colipase-like PF15083.6 KPI88976.1 - 0.7 10.1 6.6 0.15 12.2 1.8 2.0 1 1 1 2 2 2 0 Colipase-like UCR_hinge PF02320.16 KPI88976.1 - 1.4 9.2 7.0 2.9 8.2 1.1 2.9 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein TauE PF01925.19 KPI88977.1 - 1.1e-25 90.7 34.9 1.1e-11 44.8 1.2 2.4 2 1 1 3 3 3 3 Sulfite exporter TauE/SafE BatD PF13584.6 KPI88977.1 - 0.075 11.8 0.1 0.14 10.9 0.1 1.4 1 1 0 1 1 1 0 Oxygen tolerance TraQ PF09679.10 KPI88977.1 - 0.14 12.1 2.5 0.47 10.4 1.3 2.4 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Ctr PF04145.15 KPI88977.1 - 2.6 8.7 6.6 3 8.5 4.3 2.4 1 1 1 2 2 2 0 Ctr copper transporter family Profilin PF00235.19 KPI88979.1 - 2e-42 144.5 0.3 2.5e-42 144.1 0.3 1.1 1 0 0 1 1 1 1 Profilin CDC50 PF03381.15 KPI88980.1 - 6.2e-49 167.0 0.0 7.3e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Ras PF00071.22 KPI88981.1 - 2.8e-56 189.6 0.1 3.7e-56 189.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI88981.1 - 1.2e-34 119.1 0.0 1.9e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI88981.1 - 1.3e-14 54.0 0.1 1.5e-14 53.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI88981.1 - 1.3e-06 28.0 0.0 1.5e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KPI88981.1 - 1.7e-05 24.5 0.3 0.00046 19.8 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI88981.1 - 0.00028 20.9 0.0 0.00056 20.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KPI88981.1 - 0.0035 17.1 0.1 0.016 15.0 0.0 1.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 KPI88981.1 - 0.0062 15.8 0.0 0.0095 15.2 0.0 1.2 1 0 0 1 1 1 1 Septin NACHT PF05729.12 KPI88981.1 - 0.0089 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain RsgA_GTPase PF03193.16 KPI88981.1 - 0.011 15.7 0.0 0.57 10.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase SRPRB PF09439.10 KPI88981.1 - 0.015 14.7 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 KPI88981.1 - 0.02 15.1 0.0 0.1 12.9 0.0 2.0 2 1 0 3 3 3 0 AAA domain AAA_29 PF13555.6 KPI88981.1 - 0.029 14.1 0.0 0.079 12.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 KPI88981.1 - 0.052 13.0 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DAP3 PF10236.9 KPI88981.1 - 0.061 12.5 0.1 0.36 10.0 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.27 KPI88981.1 - 0.099 13.2 0.1 0.13 12.8 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 KPI88981.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 KPI88981.1 - 0.14 12.5 0.0 0.23 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KPI88981.1 - 0.17 11.0 0.1 0.51 9.4 0.1 1.7 1 1 1 2 2 2 0 G-protein alpha subunit HSBP1 PF06825.12 KPI88982.1 - 0.026 14.4 3.7 0.049 13.5 2.5 2.0 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Rtf2 PF04641.12 KPI88983.1 - 3e-20 72.7 0.3 6.8e-20 71.5 0.3 1.6 1 1 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 KPI88983.1 - 0.002 18.0 1.2 0.0043 16.9 1.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KPI88983.1 - 0.045 14.1 5.1 0.085 13.2 5.1 1.5 1 0 0 1 1 1 0 Ring finger domain Pellino PF04710.14 KPI88983.1 - 0.15 10.7 1.0 0.23 10.1 1.0 1.3 1 0 0 1 1 1 0 Pellino zf-C3HC4_3 PF13920.6 KPI88983.1 - 0.16 11.9 3.5 0.65 9.9 3.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS1595 PF12760.7 KPI88983.1 - 0.25 11.3 3.0 7.6 6.6 0.0 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain LRR_6 PF13516.6 KPI88984.1 - 1.1e-11 43.8 25.9 0.048 13.7 0.0 10.7 12 0 0 12 12 12 4 Leucine Rich repeat LRR_1 PF00560.33 KPI88984.1 - 8.9e-08 31.7 7.5 16 6.6 0.0 8.7 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.7 KPI88984.1 - 0.008 16.6 15.1 68 4.1 0.0 8.4 8 3 1 10 10 10 0 Leucine Rich repeats (2 copies) Cwf_Cwc_15 PF04889.12 KPI88984.1 - 6.6 6.4 33.8 7.4 6.2 2.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Aldo_ket_red PF00248.21 KPI88985.1 - 2.2e-57 194.5 0.0 2.1e-55 188.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DHR10 PF18595.1 KPI88986.1 - 0.014 15.4 5.4 0.014 15.4 5.4 3.4 3 1 0 4 4 4 0 Designed helical repeat protein 10 domain DUF3073 PF11273.8 KPI88986.1 - 0.13 13.1 0.3 0.53 11.1 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) FTA4 PF13093.6 KPI88986.1 - 5.1 6.9 8.4 0.96 9.3 0.8 2.9 3 0 0 3 3 3 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 LRR_4 PF12799.7 KPI88987.1 - 8.8e-32 108.6 28.1 0.00024 21.4 0.3 13.7 9 4 6 15 15 15 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI88987.1 - 5.4e-12 45.3 26.7 0.0042 16.8 0.5 7.7 6 1 3 9 9 9 4 Leucine rich repeat LRR_9 PF14580.6 KPI88987.1 - 4e-05 23.2 11.5 0.55 9.7 0.2 5.4 2 1 2 6 6 6 3 Leucine-rich repeat LRR_6 PF13516.6 KPI88987.1 - 0.00075 19.4 22.4 0.035 14.2 0.0 10.4 12 0 0 12 12 12 1 Leucine Rich repeat Roc PF08477.13 KPI88988.1 - 6.7e-05 23.1 0.0 0.00051 20.2 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KPI88988.1 - 0.0048 17.3 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KPI88988.1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.22 KPI88988.1 - 0.029 14.0 0.0 0.089 12.4 0.0 1.7 2 0 0 2 2 2 0 Ras family AAA_7 PF12775.7 KPI88988.1 - 0.12 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KPI88988.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KPI88988.1 - 0.16 11.4 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein WD40 PF00400.32 KPI88989.1 - 3e-36 122.8 17.2 2.3e-06 28.2 0.1 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI88989.1 - 1.3e-06 28.6 0.0 0.095 13.0 0.0 4.5 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KPI88989.1 - 0.00059 19.3 0.0 0.0082 15.5 0.0 2.2 1 1 1 2 2 2 1 WD40-like domain PPR_2 PF13041.6 KPI88990.1 - 1.3e-39 134.1 1.4 3e-14 53.0 0.5 5.1 3 1 2 5 5 5 4 PPR repeat family PPR_3 PF13812.6 KPI88990.1 - 3.3e-34 116.8 0.4 1.6e-09 37.7 0.1 4.6 2 1 3 5 5 5 4 Pentatricopeptide repeat domain PPR PF01535.20 KPI88990.1 - 1.1e-30 103.6 0.2 3.5e-05 23.8 0.0 6.2 6 0 0 6 6 6 5 PPR repeat PPR_1 PF12854.7 KPI88990.1 - 1.2e-29 101.7 0.1 2.6e-08 33.4 0.0 5.9 6 0 0 6 6 6 5 PPR repeat PPR_long PF17177.4 KPI88990.1 - 1.2e-18 67.3 1.0 1.3e-14 54.0 0.1 2.2 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 KPI88990.1 - 0.00046 20.8 1.3 6 8.0 0.0 4.8 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI88990.1 - 0.0011 19.4 0.1 0.41 11.2 0.0 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat ATP13 PF12921.7 KPI88990.1 - 0.028 14.3 0.0 1.8 8.5 0.0 3.0 2 1 2 4 4 4 0 Mitochondrial ATPase expression TPR_7 PF13176.6 KPI88990.1 - 0.07 13.2 0.0 29 5.0 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Augurin PF15187.6 KPI88992.1 - 0.016 15.4 0.4 0.066 13.4 0.4 2.1 1 0 0 1 1 1 0 Oesophageal cancer-related gene 4 DUF1749 PF08538.10 KPI88993.1 - 1.3e-11 44.1 0.0 2e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) FAST_1 PF06743.15 KPI88995.1 - 0.064 13.2 0.1 21 5.1 0.0 3.0 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 PIG-P PF08510.12 KPI88996.1 - 6.2e-28 97.1 4.0 7e-28 97.0 4.0 1.0 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 KPI88996.1 - 0.29 11.5 10.9 0.67 10.3 10.9 1.6 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4923 PF16270.5 KPI88998.1 - 0.059 13.2 0.1 0.059 13.2 0.1 1.8 2 0 0 2 2 2 0 Lipocalin-like domain (DUF4923) Flavodoxin_1 PF00258.25 KPI88999.1 - 1.2e-58 197.4 0.0 3.7e-24 85.6 0.0 5.4 5 0 0 5 5 5 5 Flavodoxin FAD_binding_1 PF00667.20 KPI88999.1 - 1.8e-19 70.2 0.0 3.2e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KPI88999.1 - 3.6e-12 46.9 0.0 1.7e-11 44.7 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain WD40 PF00400.32 KPI89001.1 - 3e-09 37.3 6.6 0.48 11.4 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89001.1 - 2.1e-08 34.4 0.0 2.6 8.4 0.0 5.1 3 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain AF-4 PF05110.13 KPI89001.1 - 2.8 5.9 24.2 4.9 5.1 24.2 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Abhydrolase_6 PF12697.7 KPI89002.1 - 0.00019 22.1 3.6 0.59 10.7 0.0 3.6 4 0 0 4 4 4 2 Alpha/beta hydrolase family Cyt-b5 PF00173.28 KPI89004.1 - 2.8e-16 59.4 0.1 3.1e-16 59.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FlxA PF14282.6 KPI89005.1 - 0.0013 18.6 0.8 0.12 12.4 0.1 2.1 2 0 0 2 2 2 1 FlxA-like protein Baculo_PEP_C PF04513.12 KPI89005.1 - 0.0031 17.5 0.0 0.0037 17.3 0.0 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.18 KPI89005.1 - 0.0039 17.4 0.2 0.0039 17.4 0.2 2.7 3 1 0 3 3 2 1 Homeobox associated leucine zipper TMF_DNA_bd PF12329.8 KPI89005.1 - 0.004 17.1 8.0 0.12 12.4 1.6 2.3 2 1 0 2 2 2 2 TATA element modulatory factor 1 DNA binding ZapB PF06005.12 KPI89005.1 - 0.0045 17.4 12.8 1.3 9.5 12.8 2.4 1 1 0 1 1 1 1 Cell division protein ZapB Golgin_A5 PF09787.9 KPI89005.1 - 0.0051 16.3 3.3 0.016 14.7 3.3 1.7 1 1 0 1 1 1 1 Golgin subfamily A member 5 Phage_GP20 PF06810.11 KPI89005.1 - 0.012 15.4 3.8 0.066 13.0 0.8 1.9 1 1 1 2 2 2 0 Phage minor structural protein GP20 Spc7 PF08317.11 KPI89005.1 - 0.012 14.5 8.5 0.015 14.2 8.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Cortex-I_coil PF09304.10 KPI89005.1 - 0.015 15.5 3.1 0.015 15.5 3.1 2.0 1 1 1 2 2 2 0 Cortexillin I, coiled coil YabA PF06156.13 KPI89005.1 - 0.045 14.4 6.6 0.36 11.5 1.5 2.1 1 1 0 2 2 2 0 Initiation control protein YabA SKA2 PF16740.5 KPI89005.1 - 0.048 13.4 2.6 0.071 12.9 2.6 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF4201 PF13870.6 KPI89005.1 - 0.057 13.2 7.4 0.16 11.7 7.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF3450 PF11932.8 KPI89005.1 - 0.062 12.6 9.6 0.023 14.0 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.22 KPI89005.1 - 0.068 13.4 4.7 1.5 9.1 0.3 2.2 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Uso1_p115_C PF04871.13 KPI89005.1 - 0.069 13.5 9.3 0.18 12.1 9.3 1.7 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Dynactin_p22 PF07426.11 KPI89005.1 - 0.073 12.9 5.9 0.15 11.9 1.8 2.0 2 0 0 2 2 2 0 Dynactin subunit p22 UPF0242 PF06785.11 KPI89005.1 - 0.076 13.1 4.3 0.1 12.7 4.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sipho_Gp157 PF05565.11 KPI89005.1 - 0.092 12.8 0.5 0.092 12.8 0.5 2.6 2 1 1 3 3 3 0 Siphovirus Gp157 GAS PF13851.6 KPI89005.1 - 0.093 12.1 7.7 0.15 11.3 7.7 1.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Sugarporin_N PF11471.8 KPI89005.1 - 0.11 12.5 9.8 0.11 12.5 4.2 2.5 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Atg14 PF10186.9 KPI89005.1 - 0.12 11.5 6.8 0.18 10.9 6.8 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rootletin PF15035.6 KPI89005.1 - 0.15 12.1 7.0 0.19 11.8 7.0 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion TolA_bind_tri PF16331.5 KPI89005.1 - 0.22 11.6 10.1 1.6 8.8 3.7 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Syntaxin-6_N PF09177.11 KPI89005.1 - 0.25 11.9 3.6 2.2 8.9 3.6 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal AAA_13 PF13166.6 KPI89005.1 - 0.25 9.9 4.4 0.4 9.3 4.4 1.3 1 1 0 1 1 1 0 AAA domain DUF4094 PF13334.6 KPI89005.1 - 0.25 11.8 4.0 0.59 10.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) FlaC_arch PF05377.11 KPI89005.1 - 0.36 11.3 3.0 13 6.3 0.2 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) KASH_CCD PF14662.6 KPI89005.1 - 0.49 10.2 9.3 1.2 9.0 9.3 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH CCDC-167 PF15188.6 KPI89005.1 - 0.55 10.6 8.9 9.3 6.7 8.8 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 GIT_CC PF16559.5 KPI89005.1 - 0.81 9.6 7.1 3.8 7.5 0.7 2.7 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 KPI89005.1 - 0.84 9.4 13.7 0.2 11.4 2.9 2.6 2 1 1 3 3 3 0 Septum formation initiator Cnn_1N PF07989.11 KPI89005.1 - 0.91 9.7 8.4 0.47 10.7 2.3 2.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 ATG16 PF08614.11 KPI89005.1 - 0.92 9.7 13.0 3.2 7.9 13.0 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) PspA_IM30 PF04012.12 KPI89005.1 - 0.92 9.0 15.1 1.2 8.7 4.4 2.0 1 1 0 2 2 2 0 PspA/IM30 family Erythro_esteras PF05139.14 KPI89005.1 - 0.99 9.2 5.5 1.1 8.9 5.5 1.0 1 0 0 1 1 1 0 Erythromycin esterase DHR10 PF18595.1 KPI89005.1 - 1.3 9.1 16.6 2.1 8.5 5.9 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF4140 PF13600.6 KPI89005.1 - 1.4 9.4 12.9 5.2 7.6 2.7 2.3 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ADIP PF11559.8 KPI89005.1 - 1.5 8.9 12.2 0.58 10.2 3.0 2.0 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.20 KPI89005.1 - 1.5 8.8 8.5 2.1 8.3 0.4 2.7 2 1 1 3 3 3 0 Prefoldin subunit TMF_TATA_bd PF12325.8 KPI89005.1 - 1.8 8.8 11.5 3 8.1 4.8 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 KPI89005.1 - 2.1 7.6 9.9 2.9 7.2 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) bZIP_2 PF07716.15 KPI89005.1 - 2.1 8.5 14.1 0.9 9.7 1.4 3.3 2 1 1 3 3 3 0 Basic region leucine zipper DUF2968 PF11180.8 KPI89005.1 - 2.2 7.9 12.0 3.9 7.1 2.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) FUSC PF04632.12 KPI89005.1 - 3.4 6.1 6.4 3.6 6.0 6.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TSC22 PF01166.18 KPI89005.1 - 4.8 7.6 8.0 1.2 9.5 1.1 2.8 2 1 0 2 2 2 0 TSC-22/dip/bun family SlyX PF04102.12 KPI89005.1 - 5.6 7.7 11.0 12 6.6 1.2 2.7 1 1 1 2 2 2 0 SlyX VPS9 PF02204.18 KPI89006.1 - 7.9e-28 96.7 0.0 1.9e-27 95.5 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RL10P_insert PF17777.1 KPI89007.1 - 5.1e-25 87.3 0.0 8.3e-25 86.6 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 KPI89007.1 - 5e-20 71.5 0.0 7.5e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Esterase_phd PF10503.9 KPI89008.1 - 9.6e-08 31.8 0.4 2e-07 30.8 0.4 1.5 1 0 0 1 1 1 1 Esterase PHB depolymerase Esterase PF00756.20 KPI89008.1 - 2.3e-05 24.2 0.7 7.6e-05 22.5 0.0 2.1 2 1 0 2 2 2 1 Putative esterase Peptidase_S9 PF00326.21 KPI89008.1 - 6.8e-05 22.4 3.7 0.00048 19.7 0.1 3.3 2 1 2 4 4 4 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KPI89008.1 - 0.00047 20.0 0.1 0.006 16.4 0.0 2.6 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.18 KPI89008.1 - 0.071 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Med19 PF10278.9 KPI89008.1 - 0.11 12.5 8.9 0.17 11.8 8.9 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Ham1p_like PF01725.16 KPI89010.1 - 1e-46 159.2 0.0 1.2e-46 159.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family FliE PF02049.18 KPI89010.1 - 0.14 12.3 0.1 10 6.3 0.0 2.4 2 0 0 2 2 2 0 Flagellar hook-basal body complex protein FliE DUF4692 PF15763.5 KPI89011.1 - 0.21 12.1 6.2 0.19 12.2 0.6 2.8 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) RILP PF11461.8 KPI89012.1 - 0.042 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Rab interacting lysosomal protein FliJ PF02050.16 KPI89012.1 - 1.1 9.5 14.1 7.1 6.9 8.5 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein Dodecin PF07311.12 KPI89012.1 - 1.4 9.2 5.0 0.44 10.8 0.3 2.6 3 0 0 3 3 3 0 Dodecin YlqD PF11068.8 KPI89012.1 - 2.6 8.4 10.5 7.8 6.9 10.5 1.8 1 0 0 1 1 1 0 YlqD protein Syntaxin_2 PF14523.6 KPI89012.1 - 6.2 7.3 9.4 2.8 8.4 5.3 2.3 2 0 0 2 2 2 0 Syntaxin-like protein HTH_Crp_2 PF13545.6 KPI89012.1 - 6.3 6.9 8.2 4.1 7.4 0.1 3.4 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain Transmemb_17 PF09799.9 KPI89013.1 - 8.1e-14 52.1 8.5 1.1e-13 51.7 8.5 1.2 1 0 0 1 1 1 1 Predicted membrane protein CDC24_OB1 PF17246.2 KPI89013.1 - 0.021 14.9 0.1 0.087 12.9 0.0 1.8 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 1 PAP2 PF01569.21 KPI89013.1 - 0.041 13.7 2.8 0.066 13.0 2.8 1.4 1 0 0 1 1 1 0 PAP2 superfamily zf-HC5HC2H PF13771.6 KPI89014.1 - 2.5e-05 24.4 15.9 2.5e-05 24.4 15.9 4.3 3 2 1 4 4 4 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KPI89014.1 - 5.8e-05 23.2 14.8 5.8e-05 23.2 14.8 3.7 4 1 0 4 4 4 1 PHD-zinc-finger like domain MPS2 PF17060.5 KPI89016.1 - 0.098 11.9 0.3 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Monopolar spindle protein 2 PSP1 PF04468.12 KPI89017.1 - 4.3e-27 94.2 0.6 9.4e-27 93.1 0.6 1.6 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DASH_Spc34 PF08657.10 KPI89017.1 - 0.057 13.2 1.3 0.1 12.4 1.3 1.3 1 0 0 1 1 1 0 DASH complex subunit Spc34 RalF_SCD PF18248.1 KPI89017.1 - 0.16 11.9 0.1 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 RalF C-terminal Sec-7 capping domain HJURP_C PF12347.8 KPI89017.1 - 0.17 11.9 1.1 0.51 10.4 1.1 1.8 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat DUF1690 PF07956.11 KPI89017.1 - 0.18 12.2 1.5 0.33 11.4 1.5 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Alpha_kinase PF02816.18 KPI89018.1 - 1.4e-56 191.6 0.9 1.7e-56 191.3 0.9 1.1 1 0 0 1 1 1 1 Alpha-kinase family Alpha_kinase PF02816.18 KPI89019.1 - 4.9e-76 255.0 0.0 3.2e-37 128.4 0.0 3.8 3 1 0 3 3 3 3 Alpha-kinase family Alpha_kinase PF02816.18 KPI89020.1 - 7.9e-47 159.8 0.1 1.1e-46 159.3 0.1 1.2 1 0 0 1 1 1 1 Alpha-kinase family ABC1 PF03109.16 KPI89021.1 - 1.3e-28 99.5 0.0 2.1e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family HrpF PF06266.12 KPI89022.1 - 0.35 11.2 1.6 7.2 7.0 0.3 2.7 2 0 0 2 2 2 0 HrpF protein tRNA_edit PF04073.15 KPI89023.1 - 1.6e-08 34.7 0.0 4.3e-08 33.3 0.0 1.7 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain EP400_N PF15790.5 KPI89023.1 - 0.21 10.4 0.8 0.41 9.4 0.5 1.6 1 1 0 1 1 1 0 E1A-binding protein p400, N-terminal tRNA-synt_2 PF00152.20 KPI89026.1 - 1.9e-62 211.2 0.0 6e-62 209.5 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KPI89026.1 - 4.5e-08 33.0 0.0 7.4e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KPI89026.1 - 2.6e-06 27.1 0.1 0.008 15.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Phage_TAC_2 PF06894.11 KPI89026.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage lambda tail assembly chaperone, TAC, protein G CAP_C PF08603.11 KPI89027.1 - 1.2e-22 80.2 0.0 2e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.19 KPI89027.1 - 3.7e-09 36.5 18.9 2.5e-07 30.5 0.0 3.8 2 1 1 3 3 3 2 Adenylate cyclase associated (CAP) N terminal MutS_V PF00488.21 KPI89028.1 - 2e-32 112.8 0.0 9.5e-32 110.5 0.0 2.0 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 KPI89028.1 - 2.9e-18 66.8 0.0 1.6e-17 64.3 0.0 2.1 1 1 0 1 1 1 1 MutS domain III AAA_21 PF13304.6 KPI89028.1 - 0.0013 18.6 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI89028.1 - 0.027 15.0 0.3 0.027 15.0 0.3 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KPI89028.1 - 0.068 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 KPI89028.1 - 0.1 13.1 0.2 0.26 11.8 0.2 1.6 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 KPI89028.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KPI89028.1 - 0.11 12.7 0.1 0.66 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KPI89028.1 - 0.12 12.7 2.3 0.81 10.0 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain DUF4499 PF14934.6 KPI89029.1 - 3.8e-05 23.9 4.0 3.8e-05 23.9 4.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4499) ABC2_membrane PF01061.24 KPI89031.1 - 6.6e-06 25.7 17.4 1.3e-05 24.7 17.4 1.5 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KPI89031.1 - 0.00014 22.4 0.0 0.00026 21.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter PDR_CDR PF06422.12 KPI89031.1 - 0.082 12.8 0.0 0.47 10.4 0.0 2.2 2 0 0 2 2 2 0 CDR ABC transporter Rab5ip PF07019.12 KPI89031.1 - 0.81 10.3 9.0 0.05 14.2 2.6 2.4 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) DUF4042 PF13251.6 KPI89032.1 - 1.2e-12 47.9 0.2 5.1e-10 39.3 0.0 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.6 KPI89032.1 - 2.6e-08 34.1 5.2 0.012 16.0 0.2 4.7 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 KPI89032.1 - 2.7e-06 27.2 0.6 10 6.7 0.0 6.2 5 1 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 KPI89032.1 - 2.4e-05 24.7 12.0 0.092 13.3 0.4 6.2 5 0 0 5 5 5 2 HEAT-like repeat Adaptin_N PF01602.20 KPI89032.1 - 0.049 12.2 0.0 0.3 9.6 0.0 2.1 2 1 0 2 2 2 0 Adaptin N terminal region Cnd1 PF12717.7 KPI89032.1 - 0.066 13.2 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KPI89033.1 - 0.0028 17.8 0.5 0.97 9.9 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat zf-BED PF02892.15 KPI89035.1 - 0.02 14.9 0.0 0.02 14.9 0.0 4.4 6 0 0 6 6 6 0 BED zinc finger CpXC PF14353.6 KPI89035.1 - 0.13 12.3 0.0 0.13 12.3 0.0 4.7 5 2 0 6 6 6 0 CpXC protein zinc_ribbon_4 PF13717.6 KPI89035.1 - 0.58 10.1 0.0 0.58 10.1 0.0 6.2 7 0 0 7 7 7 0 zinc-ribbon domain BAG PF02179.16 KPI89037.1 - 3.9e-05 24.0 0.9 8.8e-05 22.9 0.9 1.6 1 1 0 1 1 1 1 BAG domain Pkinase PF00069.25 KPI89038.1 - 6.3e-46 156.9 0.0 3.5e-34 118.4 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89038.1 - 4.7e-26 91.6 0.0 7.2e-16 58.3 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI89038.1 - 3.1e-08 33.3 0.0 6.1e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like SCIMP PF15050.6 KPI89039.1 - 0.0075 16.7 0.8 0.96 9.9 0.0 2.8 2 0 0 2 2 2 2 SCIMP protein FUSC_2 PF13515.6 KPI89041.1 - 0.00014 22.0 9.2 0.00014 22.0 9.2 2.7 2 1 0 2 2 2 1 Fusaric acid resistance protein-like Lipase_GDSL_2 PF13472.6 KPI89041.1 - 0.0054 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CYYR1 PF10873.8 KPI89042.1 - 0.057 13.9 4.9 0.18 12.2 4.9 1.8 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Prenyltrans PF00432.21 KPI89043.1 - 2.1e-22 78.5 20.3 5.6e-05 22.8 0.0 6.4 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KPI89043.1 - 0.049 12.7 0.0 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain Molybdopterin PF00384.22 KPI89043.1 - 0.094 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase COG7 PF10191.9 KPI89044.1 - 6.9e-06 24.6 15.1 0.011 14.1 3.1 6.1 6 1 0 6 6 6 4 Golgi complex component 7 (COG7) PhoD PF09423.10 KPI89045.1 - 0.00013 21.1 0.2 0.012 14.6 0.0 2.6 2 1 0 2 2 2 2 PhoD-like phosphatase Methyltransf_16 PF10294.9 KPI89046.1 - 0.00013 21.8 0.0 0.1 12.4 0.0 2.4 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_25 PF13649.6 KPI89046.1 - 0.001 19.7 0.1 0.2 12.4 0.0 3.4 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI89046.1 - 0.12 13.1 0.0 0.66 10.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Abhydrolase_6 PF12697.7 KPI89050.1 - 1.7e-13 51.7 0.2 2.2e-13 51.3 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KPI89050.1 - 6.9e-05 22.2 0.4 0.21 10.9 0.0 3.9 4 0 0 4 4 4 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI89050.1 - 0.00016 21.4 0.5 0.0015 18.3 0.6 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF915 PF06028.11 KPI89050.1 - 0.00023 20.6 0.0 0.00089 18.7 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.13 KPI89050.1 - 0.025 14.3 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein DUF1749 PF08538.10 KPI89050.1 - 0.098 11.7 0.1 0.33 10.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Peptidase_S10 PF00450.22 KPI89050.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase LCAT PF02450.15 KPI89050.1 - 0.14 11.3 0.1 0.22 10.7 0.1 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DSBA PF01323.20 KPI89051.1 - 1.5e-20 73.8 0.0 5.5e-20 72.0 0.0 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 KPI89051.1 - 0.079 13.4 0.0 4.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like domain RRM_1 PF00076.22 KPI89052.1 - 7.8e-18 64.1 0.0 1.5e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI89052.1 - 2e-05 24.2 0.0 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI89052.1 - 0.0027 17.8 0.0 0.0062 16.6 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 KPI89052.1 - 0.0077 16.5 0.4 0.25 11.5 0.1 2.4 1 1 1 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter Glutaredoxin PF00462.24 KPI89053.1 - 1.9e-05 24.8 0.0 5e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 KPI89053.1 - 3.2e-05 24.3 0.0 0.00019 21.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KPI89053.1 - 0.00098 19.4 0.0 0.0026 18.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_4 PF14834.6 KPI89053.1 - 0.079 13.3 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain 3HCDH_N PF02737.18 KPI89054.1 - 8.1e-52 175.7 1.8 2.1e-51 174.4 1.8 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KPI89054.1 - 2.5e-37 127.4 0.2 4.8e-24 84.8 0.0 3.0 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_1 PF00378.20 KPI89054.1 - 3.4e-32 111.7 0.3 7.9e-32 110.5 0.2 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KPI89054.1 - 2.7e-23 83.0 0.1 6.9e-23 81.7 0.1 1.7 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase NAD_binding_2 PF03446.15 KPI89054.1 - 8.6e-05 22.8 2.4 0.00014 22.1 0.4 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KPI89054.1 - 0.012 15.7 3.6 1.9 8.6 0.2 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 KPI89054.1 - 0.11 12.0 1.0 0.26 10.9 0.2 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.17 KPI89054.1 - 0.63 10.7 6.1 0.75 10.4 2.6 2.9 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SNF2_N PF00176.23 KPI89056.1 - 1.9e-32 112.4 1.5 2.3e-20 72.6 0.0 3.1 3 0 0 3 3 3 3 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 KPI89056.1 - 4.5e-07 29.8 1.7 1.3e-06 28.3 1.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Helicase_C PF00271.31 KPI89056.1 - 1.7e-06 28.3 0.0 4.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 KPI89056.1 - 3e-05 23.8 4.6 3e-05 23.8 4.6 3.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI89056.1 - 3.7e-05 24.0 4.6 3.7e-05 24.0 4.6 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 KPI89056.1 - 6.8e-05 22.7 4.5 0.00022 21.1 4.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI89056.1 - 0.0001 22.2 4.8 0.0001 22.2 4.8 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KPI89056.1 - 0.00055 19.7 5.9 0.002 18.0 5.9 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KPI89056.1 - 0.0017 18.4 6.0 0.0072 16.5 6.0 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 KPI89056.1 - 0.089 12.9 2.5 0.37 11.0 2.5 2.1 1 0 0 1 1 1 0 zinc RING finger of MSL2 Steroid_dh PF02544.16 KPI89057.1 - 3.1e-21 75.9 9.1 1.3e-10 41.5 0.0 5.0 6 0 0 6 6 6 4 3-oxo-5-alpha-steroid 4-dehydrogenase Kinesin PF00225.23 KPI89058.1 - 3.3e-87 292.5 0.1 6.1e-87 291.7 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI89058.1 - 3.2e-24 85.6 0.0 1e-23 83.9 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding Calpain_III PF01067.22 KPI89058.1 - 8.5e-13 48.8 0.0 3.3e-10 40.4 0.0 3.0 2 0 0 2 2 2 1 Calpain large subunit, domain III Arm PF00514.23 KPI89058.1 - 1.1e-07 31.6 2.2 0.081 13.0 0.1 5.5 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KPI89058.1 - 0.0077 16.6 2.6 0.21 12.0 0.2 3.4 2 1 2 4 4 4 1 HEAT repeats Atx10homo_assoc PF09759.9 KPI89058.1 - 0.074 13.1 2.8 0.43 10.6 0.0 3.5 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain DUF1192 PF06698.11 KPI89058.1 - 0.11 12.5 1.9 0.43 10.7 1.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Med9 PF07544.13 KPI89058.1 - 3.9 7.6 9.1 11 6.2 0.3 2.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Methyltr_RsmB-F PF01189.17 KPI89060.1 - 1.2e-24 87.0 0.0 2.7e-15 56.6 0.0 3.9 3 1 0 3 3 3 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KPI89060.1 - 0.014 15.5 0.0 0.082 13.0 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase TetR_C_6 PF13977.6 KPI89060.1 - 2.4 8.4 9.6 0.24 11.6 3.5 2.6 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal WW PF00397.26 KPI89061.1 - 5.5e-08 32.8 0.1 1.2e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 WW domain GPW_gp25 PF04965.14 KPI89061.1 - 3.2 7.6 6.0 1.5 8.6 0.3 2.7 2 0 0 2 2 2 0 Gene 25-like lysozyme XRN_N PF03159.18 KPI89062.1 - 1e-72 244.5 0.0 1.5e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KPI89062.1 - 7.7e-36 124.0 0.0 4.8e-23 81.8 0.0 2.1 1 1 1 2 2 2 2 Xrn1 helical domain zf-RanBP PF00641.18 KPI89062.1 - 4.7e-06 25.8 3.1 1.2e-05 24.5 3.1 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others UDPGP PF01704.18 KPI89063.1 - 1.9e-11 43.3 0.0 3.6e-10 39.0 0.0 2.1 1 1 1 2 2 2 2 UTP--glucose-1-phosphate uridylyltransferase CdvA PF18822.1 KPI89065.1 - 0.15 11.9 0.9 0.3 10.9 0.9 1.4 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Fzo_mitofusin PF04799.13 KPI89065.1 - 0.16 11.5 1.1 0.37 10.3 1.1 1.5 1 0 0 1 1 1 0 fzo-like conserved region WD40_alt PF14077.6 KPI89065.1 - 0.2 11.6 0.9 0.53 10.2 0.7 1.8 1 1 1 2 2 2 0 Alternative WD40 repeat motif APG6_N PF17675.1 KPI89065.1 - 2.4 8.7 9.9 6.4 7.3 9.9 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region ATG16 PF08614.11 KPI89067.1 - 0.0001 22.6 2.2 0.0001 22.6 2.2 4.0 5 0 0 5 5 5 2 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 KPI89067.1 - 0.23 11.9 6.1 1.7 9.1 1.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) UPF0242 PF06785.11 KPI89067.1 - 0.66 10.1 4.1 1.1 9.4 4.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus BRE1 PF08647.11 KPI89067.1 - 1.3 9.1 10.7 0.91 9.6 3.7 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase ADIP PF11559.8 KPI89067.1 - 1.7 8.7 12.6 0.79 9.8 4.4 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Motile_Sperm PF00635.26 KPI89068.1 - 1.4e-13 50.6 0.0 2.1e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PapD-like PF14874.6 KPI89068.1 - 0.01 16.0 0.2 0.017 15.3 0.2 1.3 1 0 0 1 1 1 0 Flagellar-associated PapD-like WW PF00397.26 KPI89069.1 - 8.4e-05 22.6 0.1 0.00016 21.7 0.1 1.4 1 0 0 1 1 1 1 WW domain Phage_GP20 PF06810.11 KPI89069.1 - 0.00025 20.9 0.8 0.00025 20.9 0.8 2.5 3 0 0 3 3 3 1 Phage minor structural protein GP20 Baculo_PEP_C PF04513.12 KPI89069.1 - 5 7.2 9.0 27 4.8 0.0 2.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Histone PF00125.24 KPI89070.1 - 1.1e-12 48.4 1.9 1.5e-12 48.0 1.9 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KPI89070.1 - 0.00031 21.0 0.4 0.00067 19.9 0.4 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GMP_synt_C PF00958.22 KPI89070.1 - 0.12 12.5 1.4 0.16 12.1 0.9 1.4 1 1 0 1 1 1 0 GMP synthase C terminal domain Pex24p PF06398.11 KPI89071.1 - 0.11 11.4 0.2 0.27 10.2 0.2 1.6 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF898 PF05987.13 KPI89071.1 - 8.9 5.3 18.1 0.035 13.1 0.3 2.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF898) TPR_2 PF07719.17 KPI89072.1 - 1.2e-11 43.8 0.2 0.057 13.6 0.0 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KPI89072.1 - 5.7e-07 29.5 0.0 0.12 12.9 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI89072.1 - 1.2e-06 29.0 5.3 0.0088 16.7 0.0 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89072.1 - 3.7e-06 27.3 19.3 0.25 12.2 0.1 8.2 6 2 3 9 9 9 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89072.1 - 7.8e-06 25.7 0.0 0.78 10.1 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI89072.1 - 1.2e-05 24.9 0.0 1.5 8.8 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI89072.1 - 0.0021 17.7 0.0 0.49 10.1 0.0 3.0 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 KPI89072.1 - 0.063 13.6 2.2 10 6.5 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat GNAT_acetyltr_2 PF13718.6 KPI89073.1 - 2.2e-79 266.0 0.1 1.5e-78 263.3 0.0 2.5 3 0 0 3 3 3 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 KPI89073.1 - 9.8e-60 201.4 0.0 2.5e-59 200.1 0.0 1.8 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.11 KPI89073.1 - 1.1e-30 105.4 0.0 4.2e-30 103.5 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.6 KPI89073.1 - 9.9e-30 104.0 1.7 3.3e-29 102.2 1.7 1.8 1 1 0 1 1 1 1 Possible tRNA binding domain AAA_30 PF13604.6 KPI89073.1 - 6.5e-05 22.7 4.7 0.00026 20.7 0.1 3.3 4 1 1 5 5 5 1 AAA domain AAA_22 PF13401.6 KPI89073.1 - 0.012 15.9 0.1 0.71 10.1 0.0 3.0 2 1 0 2 2 2 0 AAA domain Oscp1 PF10188.9 KPI89074.1 - 3e-54 183.8 0.0 3.9e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Organic solute transport protein 1 eIF2A PF08662.11 KPI89077.1 - 1.5e-13 51.1 0.0 5e-13 49.4 0.0 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Hydantoinase_B PF02538.14 KPI89077.1 - 0.11 10.9 0.7 0.16 10.4 0.7 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase DUF4145 PF13643.6 KPI89077.1 - 0.11 12.6 0.5 25 5.1 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) Caleosin PF05042.13 KPI89077.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Caleosin related protein FCH PF00611.23 KPI89077.1 - 0.14 12.5 1.3 0.31 11.3 1.3 1.5 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain COX16 PF14138.6 KPI89078.1 - 0.16 12.5 0.7 0.86 10.2 0.7 2.0 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Methyltransf_32 PF13679.6 KPI89079.1 - 1.1e-14 54.7 1.1 8.2e-07 29.1 0.2 2.9 2 1 0 2 2 2 2 Methyltransferase domain ubiquitin PF00240.23 KPI89081.1 - 0.0044 16.7 0.0 0.0077 16.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family CTP_transf_like PF01467.26 KPI89083.1 - 6.5e-17 62.1 0.0 9e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Cyt-b5 PF00173.28 KPI89084.1 - 2.3e-14 53.3 0.0 3.5e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SSFA2_C PF14723.6 KPI89084.1 - 0.069 13.1 0.3 3.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus ALO PF04030.14 KPI89085.1 - 2.6e-62 211.0 2.3 1.1e-58 199.1 0.5 2.1 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 KPI89085.1 - 1.2e-23 83.4 0.1 2e-23 82.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain SDA1 PF05285.12 KPI89086.1 - 2e-70 237.9 60.6 9.4e-40 137.1 8.5 2.7 2 1 1 3 3 3 2 SDA1 NUC130_3NT PF08158.12 KPI89086.1 - 1.4e-13 50.9 0.1 5.2e-13 49.1 0.1 2.1 1 0 0 1 1 1 1 NUC130/3NT domain IQ PF00612.27 KPI89088.1 - 2.5e-16 57.8 44.6 0.00039 20.0 0.8 7.6 7 0 0 7 7 7 6 IQ calmodulin-binding motif Inositol_P PF00459.25 KPI89089.1 - 3e-63 213.9 0.4 3.8e-63 213.5 0.4 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Peptidase_C65 PF10275.9 KPI89090.1 - 1.5e-54 185.1 0.0 1.8e-54 184.8 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain Spc7 PF08317.11 KPI89091.1 - 0.001 18.0 8.2 0.001 18.0 8.2 4.5 3 1 1 4 4 4 2 Spc7 kinetochore protein NPV_P10 PF05531.12 KPI89091.1 - 0.25 11.8 4.8 27 5.3 0.2 4.4 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 KPI89091.1 - 0.32 11.0 23.0 0.21 11.6 0.4 5.7 3 2 2 7 7 7 0 Protein of unknown function (DUF1664) GvpK PF05121.12 KPI89091.1 - 1.4 9.0 0.0 1.4 9.0 0.0 4.1 3 1 0 4 4 4 0 Gas vesicle protein K WXG100 PF06013.12 KPI89091.1 - 4.2 7.7 14.0 4 7.7 1.9 4.4 3 1 0 3 3 3 0 Proteins of 100 residues with WXG SHE3 PF17078.5 KPI89091.1 - 7 6.3 8.1 0.73 9.5 1.4 2.6 2 2 0 2 2 2 0 SWI5-dependent HO expression protein 3 zf-ZPR1 PF03367.13 KPI89092.1 - 1.2e-110 366.4 0.2 1.9e-57 193.6 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 KPI89092.1 - 0.0089 16.0 4.7 0.49 10.4 0.1 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FapA PF03961.13 KPI89093.1 - 6.1 5.3 16.1 4.9 5.6 14.0 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A Cauli_AT PF03233.13 KPI89093.1 - 8.4 6.3 6.2 2.1 8.2 1.1 2.2 1 1 0 2 2 2 0 Aphid transmission protein MFS_1 PF07690.16 KPI89095.1 - 2.6e-18 66.1 41.8 3e-17 62.6 41.2 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Herpes_LMP1 PF05297.11 KPI89095.1 - 0.022 14.0 0.1 0.043 13.0 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Ion_trans PF00520.31 KPI89096.1 - 1.1e-82 276.9 67.3 1.3e-25 90.1 6.1 4.9 4 2 1 5 5 5 5 Ion transport protein Herpes_UL49_5 PF05702.11 KPI89096.1 - 2.8 8.1 20.5 0.26 11.4 0.2 5.1 4 0 0 4 4 4 0 Herpesvirus UL49.5 envelope/tegument protein RabGAP-TBC PF00566.18 KPI89097.1 - 4.7e-15 55.8 0.1 7.7e-15 55.1 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Amastin PF07344.11 KPI89098.1 - 9.7e-24 84.0 7.6 1.2e-23 83.7 7.6 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein DUF4491 PF14898.6 KPI89098.1 - 1.2 9.6 7.0 2.3 8.7 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4491) Claudin_2 PF13903.6 KPI89098.1 - 1.5 8.5 11.0 13 5.5 0.0 2.3 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Ferrochelatase PF00762.19 KPI89099.1 - 6e-73 245.7 0.6 1.3e-57 195.3 0.0 2.0 1 1 1 2 2 2 2 Ferrochelatase CbiX PF01903.17 KPI89099.1 - 0.043 14.2 0.2 3.6 7.9 0.0 2.9 3 0 0 3 3 3 0 CbiX UL17 PF17640.2 KPI89099.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized UL17 Rad51 PF08423.11 KPI89101.1 - 2.5e-128 426.7 0.3 4.2e-128 426.0 0.2 1.4 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.6 KPI89101.1 - 5.2e-10 39.2 0.1 8.7e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KPI89101.1 - 1.7e-09 37.6 0.1 3.4e-09 36.6 0.1 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 KPI89101.1 - 1.2e-06 29.0 0.0 3.4e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 KPI89101.1 - 0.00034 20.0 0.3 0.0013 18.2 0.3 1.9 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 KPI89101.1 - 0.0035 16.7 0.1 0.016 14.5 0.0 1.9 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 KPI89101.1 - 0.042 14.1 0.1 0.1 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain Nucleoside_tran PF01733.18 KPI89102.1 - 6.2e-30 104.6 4.9 6.2e-30 104.6 4.9 2.4 2 1 0 2 2 2 1 Nucleoside transporter STIMATE PF12400.8 KPI89102.1 - 4.3 7.9 9.5 1.7 9.2 3.1 2.8 2 0 0 2 2 2 0 STIMATE family Mod_r PF07200.13 KPI89103.1 - 1.1e-11 45.1 1.8 1.9e-11 44.3 1.8 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GAS PF13851.6 KPI89103.1 - 0.0002 20.8 4.0 0.00034 20.0 4.0 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Csm1_N PF18504.1 KPI89103.1 - 0.00058 20.2 2.4 0.00058 20.2 2.4 2.1 2 0 0 2 2 2 1 Csm1 N-terminal domain TSC22 PF01166.18 KPI89103.1 - 0.0053 17.1 1.6 0.018 15.3 0.4 2.5 1 1 1 2 2 2 1 TSC-22/dip/bun family bZIP_1 PF00170.21 KPI89103.1 - 0.019 15.1 0.5 0.062 13.4 0.2 2.1 2 0 0 2 2 2 0 bZIP transcription factor DUF713 PF05218.14 KPI89103.1 - 0.049 13.4 0.6 0.13 11.9 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF713) Cnn_1N PF07989.11 KPI89103.1 - 0.07 13.3 1.8 0.23 11.6 1.5 2.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 ZapB PF06005.12 KPI89103.1 - 0.095 13.2 3.6 0.23 11.9 3.6 1.6 1 0 0 1 1 1 0 Cell division protein ZapB FliD_N PF02465.18 KPI89103.1 - 0.11 13.3 6.1 3 8.6 4.8 3.1 3 1 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus NPV_P10 PF05531.12 KPI89103.1 - 0.12 12.8 2.1 0.42 11.1 0.7 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein NBP1 PF08537.10 KPI89103.1 - 0.13 11.7 1.3 0.24 10.8 1.3 1.4 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DUF948 PF06103.11 KPI89103.1 - 2.4 8.5 5.1 1.8 8.9 1.4 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 KPI89103.1 - 5 7.6 5.8 12 6.4 0.7 3.4 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Defensin_beta PF00711.19 KPI89104.1 - 0.023 14.7 3.8 0.023 14.7 3.8 1.6 2 0 0 2 2 2 0 Beta defensin Pkinase PF00069.25 KPI89105.1 - 1.4e-56 191.8 0.0 1e-38 133.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89105.1 - 1.3e-23 83.7 0.0 1.2e-21 77.2 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 KPI89105.1 - 0.0031 16.9 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI89105.1 - 0.0046 16.9 0.0 0.016 15.1 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KPI89105.1 - 0.025 13.5 0.0 0.085 11.8 0.0 1.7 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 KPI89105.1 - 0.17 11.5 0.1 14 5.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 KPI89105.1 - 0.2 10.6 0.0 0.31 10.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 KPI89105.1 - 0.28 9.9 1.0 0.49 9.1 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase PIN_2 PF10130.9 KPI89106.1 - 0.062 13.5 0.5 0.38 11.0 0.2 2.2 2 0 0 2 2 2 0 PIN domain SlyX PF04102.12 KPI89106.1 - 0.16 12.6 8.3 2 9.1 0.9 3.4 3 0 0 3 3 3 0 SlyX CCDC106 PF15794.5 KPI89106.1 - 0.29 10.8 1.4 0.42 10.3 0.3 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 AAA_6 PF12774.7 KPI89108.1 - 2.4e-148 493.5 0.0 7.9e-147 488.5 0.0 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI89108.1 - 2e-115 386.1 0.7 2e-115 386.1 0.7 2.7 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KPI89108.1 - 1.3e-101 339.9 0.0 3.9e-101 338.3 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KPI89108.1 - 2.2e-93 312.4 0.0 1.3e-91 306.6 0.0 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KPI89108.1 - 4.5e-83 277.7 3.1 1.7e-82 275.9 3.1 2.1 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 KPI89108.1 - 3.2e-63 212.5 0.0 3.2e-58 196.2 0.0 3.6 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI89108.1 - 1.1e-53 181.5 0.0 2.6e-53 180.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KPI89108.1 - 1.2e-46 159.4 4.9 2.8e-46 158.1 4.9 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KPI89108.1 - 7e-45 152.0 0.1 8e-43 145.3 0.1 3.1 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KPI89108.1 - 6.6e-19 68.3 0.0 8.6e-18 64.7 0.0 3.1 3 0 0 3 3 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KPI89108.1 - 4.6e-15 55.8 0.7 0.00012 22.1 0.0 6.4 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KPI89108.1 - 9.8e-15 54.6 0.3 3.7e-14 52.7 0.3 2.0 1 0 0 1 1 1 1 AAA+ lid domain RNA_helicase PF00910.22 KPI89108.1 - 1.8e-06 28.3 0.1 0.25 11.7 0.0 4.9 5 0 0 5 5 5 2 RNA helicase AAA_18 PF13238.6 KPI89108.1 - 1.2e-05 25.8 0.4 0.098 13.2 0.0 3.9 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 KPI89108.1 - 4.5e-05 23.3 3.6 1.2 8.8 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 KPI89108.1 - 0.00025 21.5 0.9 2 8.8 0.0 4.5 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI89108.1 - 0.00067 19.9 10.2 3.4 8.0 0.0 5.8 6 0 0 6 6 5 1 AAA domain AAA_24 PF13479.6 KPI89108.1 - 0.002 17.9 0.5 0.22 11.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 KPI89108.1 - 0.006 15.7 1.3 0.91 8.5 0.0 4.2 5 0 0 5 5 5 1 Type II/IV secretion system protein AAA_33 PF13671.6 KPI89108.1 - 0.012 15.8 1.1 7.8 6.7 0.0 4.0 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 KPI89108.1 - 0.019 14.9 0.8 21 5.0 0.0 4.0 3 0 0 3 3 3 0 NACHT domain Mg_chelatase PF01078.21 KPI89108.1 - 0.091 12.1 5.6 0.95 8.8 0.0 4.4 5 0 0 5 5 5 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KPI89108.1 - 0.13 11.7 2.8 6.8 6.1 0.0 3.4 3 0 0 3 3 3 0 PhoH-like protein AAA_25 PF13481.6 KPI89108.1 - 0.17 11.4 1.4 11 5.5 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 KPI89108.1 - 0.2 12.1 0.0 0.2 12.1 0.0 5.1 5 0 0 5 5 4 0 AAA domain AAA_29 PF13555.6 KPI89108.1 - 0.21 11.4 1.2 5.1 6.9 0.0 3.3 4 0 0 4 4 2 0 P-loop containing region of AAA domain FdsD PF11390.8 KPI89108.1 - 0.23 11.8 0.9 1.5 9.2 0.1 2.9 2 0 0 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD AAA_16 PF13191.6 KPI89108.1 - 0.35 11.2 15.3 1.5 9.2 0.0 6.0 8 0 0 8 8 5 0 AAA ATPase domain Baculo_PEP_C PF04513.12 KPI89108.1 - 0.38 10.8 6.2 32 4.5 0.0 5.4 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pkinase PF00069.25 KPI89109.1 - 4.2e-52 177.1 0.0 8.7e-52 176.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89109.1 - 1.2e-36 126.3 0.0 2.3e-36 125.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Zip PF02535.22 KPI89109.1 - 0.058 12.6 0.6 0.13 11.4 0.0 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter JAB PF01398.21 KPI89109.1 - 0.16 12.0 0.0 0.67 9.9 0.0 2.1 2 0 0 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TetR_C_16 PF17920.1 KPI89109.1 - 2.4 8.5 6.4 84 3.5 1.0 4.9 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain ER_lumen_recept PF00810.18 KPI89110.1 - 1.8e-49 168.4 11.2 1.8e-49 168.4 11.2 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor ATP_synt_H PF05493.13 KPI89111.1 - 6.5e-18 65.0 6.2 7.1e-18 64.8 6.2 1.0 1 0 0 1 1 1 1 ATP synthase subunit H WD40 PF00400.32 KPI89112.1 - 1.8e-14 53.9 8.6 0.00011 22.9 0.0 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89112.1 - 6.1e-11 42.5 0.1 0.0018 18.5 0.0 3.9 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI89112.1 - 0.0065 15.5 0.2 0.066 12.2 0.1 2.7 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2304 PF10066.9 KPI89113.1 - 0.21 11.8 2.9 0.28 11.4 2.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Ank_4 PF13637.6 KPI89115.1 - 4.4e-22 78.1 0.6 6.2e-14 52.2 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI89115.1 - 8.1e-18 64.8 0.9 6.7e-12 45.8 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI89115.1 - 6.2e-15 55.1 3.7 9.4e-08 32.2 0.3 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI89115.1 - 2e-11 43.0 0.3 0.00075 19.8 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KPI89115.1 - 8.2e-07 29.2 0.2 0.014 15.8 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Metallophos PF00149.28 KPI89116.1 - 7.2e-37 127.9 0.1 9.4e-37 127.5 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI89116.1 - 8.2e-18 64.6 0.8 1.5e-17 63.7 0.8 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain BTB_2 PF02214.22 KPI89117.1 - 2.9e-11 43.6 0.0 5.9e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF4539 PF15072.6 KPI89118.1 - 7.2e-14 51.6 0.0 1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) SNARE_assoc PF09335.11 KPI89119.1 - 1.3e-09 38.6 1.0 1.3e-09 38.6 1.0 3.4 4 0 0 4 4 4 1 SNARE associated Golgi protein GGDEF_2 PF17853.1 KPI89119.1 - 2.7e-05 24.4 0.8 0.037 14.3 0.0 2.9 3 0 0 3 3 3 2 GGDEF-like domain EF-hand_1 PF00036.32 KPI89119.1 - 0.0022 17.4 0.1 0.2 11.3 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KPI89119.1 - 0.0056 16.5 0.0 0.094 12.7 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KPI89119.1 - 0.042 13.4 0.1 0.13 11.8 0.1 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KPI89119.1 - 0.054 13.9 0.1 0.41 11.1 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain pair Dockerin_1 PF00404.18 KPI89119.1 - 0.16 12.2 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Dockerin type I domain Sas10_Utp3 PF04000.15 KPI89120.1 - 3.8e-18 65.9 1.4 1.6e-17 63.9 1.4 2.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Sas10 PF09368.10 KPI89120.1 - 2.3e-16 60.0 4.6 8.1e-16 58.3 4.6 2.0 1 0 0 1 1 1 1 Sas10 C-terminal domain SNF2_N PF00176.23 KPI89124.1 - 2.2e-43 148.4 0.0 3.2e-43 147.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI89124.1 - 3e-17 62.9 0.2 7.4e-17 61.7 0.1 1.7 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 KPI89124.1 - 4e-07 29.8 5.1 8e-07 28.8 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI89124.1 - 4.5e-07 29.8 2.5 1e-06 28.7 2.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KPI89124.1 - 9.6e-07 28.7 6.0 2.3e-06 27.4 6.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.15 KPI89124.1 - 1.1e-06 28.8 0.0 3.1e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 KPI89124.1 - 1.7e-06 27.8 5.1 3.5e-06 26.8 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI89124.1 - 2.4e-06 27.8 6.1 2.4e-06 27.8 6.1 1.9 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 KPI89124.1 - 0.0002 21.1 5.4 0.00059 19.6 5.4 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-4CXXC_R1 PF10497.9 KPI89124.1 - 0.00026 21.2 5.7 0.00071 19.8 5.7 1.7 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 ERCC3_RAD25_C PF16203.5 KPI89124.1 - 0.00029 20.1 0.3 0.00044 19.5 0.3 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-C3HC4_2 PF13923.6 KPI89124.1 - 0.0003 20.5 9.7 0.0012 18.7 9.7 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 KPI89124.1 - 0.0094 15.7 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_4 PF15227.6 KPI89124.1 - 0.026 14.7 5.5 0.054 13.7 5.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FYVE PF01363.21 KPI89124.1 - 0.8 9.9 6.6 2.2 8.5 6.6 1.8 1 1 0 1 1 1 0 FYVE zinc finger zf-rbx1 PF12678.7 KPI89124.1 - 0.91 9.9 7.2 0.47 10.8 4.2 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain Cas6 PF09559.10 KPI89125.1 - 0.12 12.3 0.1 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 Cas6 Crispr PAP_assoc PF03828.19 KPI89127.1 - 5.9e-11 42.4 0.0 1.2e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KPI89127.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain DSPc PF00782.20 KPI89128.1 - 3.6e-20 72.1 0.0 3.7e-19 68.9 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain IL7 PF01415.16 KPI89128.1 - 0.011 15.8 0.9 0.46 10.5 0.0 2.8 3 0 0 3 3 3 0 Interleukin 7/9 family Y_phosphatase PF00102.27 KPI89128.1 - 0.025 14.1 0.1 0.041 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase EF-hand_7 PF13499.6 KPI89129.1 - 1.4e-11 44.7 0.5 1.6e-05 25.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KPI89129.1 - 1e-09 38.6 0.0 5.8e-09 36.2 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_6 PF13405.6 KPI89129.1 - 9.4e-07 28.3 0.8 0.0023 17.7 0.0 3.5 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KPI89129.1 - 1.5e-06 27.3 0.1 0.014 14.9 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KPI89129.1 - 0.00044 20.0 0.5 1.4 8.8 0.0 3.1 1 1 2 3 3 3 3 EF-hand domain pair Glycos_trans_3N PF02885.17 KPI89129.1 - 0.032 14.1 0.6 7.5 6.5 0.1 2.5 1 1 1 2 2 2 0 Glycosyl transferase family, helical bundle domain RNA_pol_Rpb8 PF03870.15 KPI89130.1 - 3.1e-35 121.4 0.0 3.5e-35 121.2 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 PucR PF07905.11 KPI89131.1 - 0.067 13.5 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family Patatin PF01734.22 KPI89131.1 - 3.2 7.9 6.7 9.7 6.3 3.2 2.3 1 1 1 2 2 2 0 Patatin-like phospholipase CSD PF00313.22 KPI89133.1 - 4.3e-16 58.5 0.6 5.7e-16 58.1 0.6 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain FXMRP1_C_core PF12235.8 KPI89135.1 - 0.019 15.6 0.7 0.026 15.2 0.7 1.3 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Phage_tail_APC PF16778.5 KPI89135.1 - 0.038 13.9 0.3 0.12 12.2 0.2 1.9 2 0 0 2 2 2 0 Phage tail assembly chaperone protein SLATT_2 PF18183.1 KPI89135.1 - 0.096 12.5 2.4 0.082 12.7 0.8 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 2 FoP_duplication PF13865.6 KPI89135.1 - 0.57 10.8 5.0 0.99 10.0 5.0 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DUF1738 PF08401.11 KPI89136.1 - 0.0018 18.3 0.0 12 6.1 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function (DUF1738) MCM PF00493.23 KPI89137.1 - 1.4e-93 312.2 0.0 2.3e-93 311.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KPI89137.1 - 7.2e-36 122.8 0.2 1.2e-35 122.1 0.2 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KPI89137.1 - 3.3e-27 94.7 0.1 8.2e-27 93.5 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KPI89137.1 - 4.2e-09 36.9 0.7 4.2e-09 36.9 0.7 2.8 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 KPI89137.1 - 1.9e-07 30.7 0.0 1.1e-05 24.9 0.0 2.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM2_N PF12619.8 KPI89137.1 - 1.4e-06 28.7 28.6 1.4e-06 28.7 28.6 3.0 4 0 0 4 4 3 1 Mini-chromosome maintenance protein 2 AAA_5 PF07728.14 KPI89137.1 - 1.4e-05 25.1 0.0 4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KPI89137.1 - 0.0014 18.5 0.0 0.0063 16.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 KPI89137.1 - 0.0036 17.1 0.1 0.016 15.1 0.1 2.1 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 KPI89137.1 - 0.025 15.0 0.0 0.071 13.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KPI89137.1 - 0.11 12.3 0.0 0.37 10.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain TMIE PF16038.5 KPI89139.1 - 0.58 10.0 2.7 1.4 8.8 2.7 1.6 1 0 0 1 1 1 0 TMIE protein Ribonuc_red_lgC PF02867.15 KPI89141.1 - 1.5e-183 611.1 0.0 1.9e-183 610.8 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KPI89141.1 - 5.4e-21 74.4 0.0 1.2e-20 73.2 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KPI89141.1 - 4.8e-10 39.9 0.0 1.2e-09 38.6 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain TMF_DNA_bd PF12329.8 KPI89142.1 - 0.0021 18.0 21.5 0.06 13.3 5.0 4.6 4 1 0 4 4 4 2 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.6 KPI89142.1 - 0.05 13.3 28.6 5.6 6.6 22.2 4.2 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4446 PF14584.6 KPI89142.1 - 0.16 11.9 4.7 3.6 7.6 0.1 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF4446) XLF PF09302.11 KPI89142.1 - 0.28 11.3 4.5 7.5 6.7 3.1 2.9 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component FAM184 PF15665.5 KPI89142.1 - 0.67 9.7 21.9 9 6.0 18.4 2.3 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B SOGA PF11365.8 KPI89142.1 - 0.69 11.1 13.9 5.7 8.1 0.2 3.8 4 0 0 4 4 4 0 Protein SOGA YgaB PF14182.6 KPI89142.1 - 1.2 9.6 14.3 1.3 9.5 1.4 4.2 4 1 1 5 5 5 0 YgaB-like protein DUF737 PF05300.11 KPI89142.1 - 4 7.7 14.3 6.9 7.0 13.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF737) Swi5 PF07061.11 KPI89142.1 - 4.1 7.5 14.4 11 6.1 0.1 5.0 5 1 0 5 5 5 0 Swi5 DivIC PF04977.15 KPI89142.1 - 5.9 6.7 29.5 3.4 7.5 3.5 5.8 3 1 3 6 6 6 0 Septum formation initiator Ead_Ea22 PF13935.6 KPI89142.1 - 7.1 7.3 13.1 4.8 7.8 8.1 2.5 1 1 1 2 2 2 0 Ead/Ea22-like protein Exo_endo_phos PF03372.23 KPI89143.1 - 0.0015 18.1 0.2 1.2 8.6 0.0 3.9 2 1 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family EF-hand_6 PF13405.6 KPI89144.1 - 9.2e-07 28.3 1.0 0.016 15.1 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KPI89144.1 - 2.1e-06 26.8 2.3 0.014 14.9 0.1 3.5 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 KPI89144.1 - 7.7e-06 25.2 0.5 0.017 14.6 0.1 2.5 2 0 0 2 2 2 2 EF hand FUN14 PF04930.15 KPI89144.1 - 0.00023 21.5 0.4 0.00041 20.7 0.4 1.4 1 0 0 1 1 1 1 FUN14 family EF-hand_8 PF13833.6 KPI89144.1 - 0.0025 17.6 0.2 0.026 14.3 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 KPI89144.1 - 0.0039 17.6 0.5 0.69 10.4 0.3 3.1 2 1 1 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 KPI89144.1 - 0.035 14.3 0.4 0.39 11.0 0.1 2.3 2 0 0 2 2 2 0 Dockerin type I domain Nup35_RRM PF05172.13 KPI89145.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif adh_short PF00106.25 KPI89147.1 - 1.3e-14 54.1 0.0 1e-08 34.9 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KPI89147.1 - 2.3e-11 43.7 0.0 5.3e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Tctex-1 PF03645.13 KPI89148.1 - 4.9e-24 84.5 0.0 5.9e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family PG_binding_2 PF08823.11 KPI89148.1 - 0.0083 16.4 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 Putative peptidoglycan binding domain WD40 PF00400.32 KPI89149.1 - 4.8e-17 62.0 5.6 0.00031 21.5 0.8 8.0 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89149.1 - 0.00013 22.2 0.0 5.6 7.3 0.0 3.9 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI89149.1 - 0.017 13.8 0.1 1.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 eIF2A PF08662.11 KPI89149.1 - 0.093 12.6 0.0 0.48 10.3 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A EAGR_box PF16713.5 KPI89149.1 - 0.26 11.0 0.2 0.5 10.1 0.2 1.5 1 0 0 1 1 1 0 Enriched in aromatic and glycine Residues box PseudoU_synth_1 PF01416.20 KPI89150.1 - 7.1e-12 45.8 0.0 8.1e-11 42.3 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF3523 PF12037.8 KPI89150.1 - 7.8 5.8 9.9 15 4.8 9.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Cir_N PF10197.9 KPI89151.1 - 0.017 15.3 1.8 0.017 15.3 1.8 3.7 4 1 1 5 5 5 0 N-terminal domain of CBF1 interacting co-repressor CIR tRNA_synthFbeta PF17759.1 KPI89152.1 - 6.2e-39 133.6 0.0 1e-38 133.0 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 KPI89152.1 - 2.2e-30 104.7 0.1 4.6e-30 103.7 0.1 1.6 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 KPI89152.1 - 1.2e-17 64.1 0.0 2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 KPI89152.1 - 7e-17 61.5 0.0 7.2e-14 51.8 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF5321 PF17254.2 KPI89153.1 - 3.3 7.1 5.9 10 5.5 5.9 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5321) DAGK_cat PF00781.24 KPI89155.1 - 3e-10 39.8 0.0 4.7e-09 35.9 0.0 2.6 2 1 0 2 2 2 1 Diacylglycerol kinase catalytic domain TetR_C_11 PF16859.5 KPI89157.1 - 0.059 13.7 0.0 0.085 13.2 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF16 PF01519.16 KPI89158.1 - 0.17 12.4 2.8 21 5.7 0.4 3.0 2 0 0 2 2 2 0 Protein of unknown function DUF16 Polyoma_coat2 PF00761.20 KPI89158.1 - 0.17 11.6 6.5 0.022 14.5 1.0 2.1 2 0 0 2 2 2 0 Polyomavirus coat protein COG5 PF10392.9 KPI89158.1 - 0.27 11.4 7.8 0.48 10.6 2.0 3.5 3 0 0 3 3 3 0 Golgi transport complex subunit 5 MCC-bdg_PDZ PF10506.9 KPI89158.1 - 2.4 8.2 7.3 0.44 10.6 0.4 3.1 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF2205 PF10224.9 KPI89158.1 - 3.7 7.6 7.5 6.4 6.9 1.0 3.9 4 0 0 4 4 4 0 Short coiled-coil protein DUF1664 PF07889.12 KPI89158.1 - 3.9 7.5 8.4 13 5.8 1.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF5320 PF17253.2 KPI89158.1 - 9.2 7.4 6.4 10 7.3 0.1 3.5 4 0 0 4 4 4 0 Family of unknown function (DUF5320) Mito_carr PF00153.27 KPI89159.1 - 1.1e-54 182.3 1.3 1.1e-18 66.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CytB6-F_Fe-S PF08802.10 KPI89159.1 - 9 6.4 6.4 16 5.6 0.7 2.9 3 0 0 3 3 3 0 Cytochrome B6-F complex Fe-S subunit PCI PF01399.27 KPI89160.1 - 1.1e-10 42.0 0.0 5.5e-10 39.7 0.0 2.2 2 0 0 2 2 2 1 PCI domain Coilin_N PF15862.5 KPI89160.1 - 0.094 12.5 0.1 7 6.5 0.0 2.2 2 0 0 2 2 2 0 Coilin N-terminus Ank_2 PF12796.7 KPI89161.1 - 5.8e-24 84.5 17.5 2.6e-05 24.7 0.2 10.0 8 2 1 10 10 10 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI89161.1 - 5.1e-14 51.0 24.2 0.044 14.4 0.1 14.0 16 0 0 16 16 16 5 Ankyrin repeat Ank_5 PF13857.6 KPI89161.1 - 7.7e-12 45.2 17.1 0.12 12.7 0.0 11.1 12 1 1 13 13 13 5 Ankyrin repeats (many copies) Ank PF00023.30 KPI89161.1 - 3.9e-10 39.7 18.7 0.0057 17.0 0.2 10.3 11 0 0 11 11 11 3 Ankyrin repeat Ank_4 PF13637.6 KPI89161.1 - 1.1e-09 38.7 21.5 0.021 15.4 0.3 9.1 10 1 2 12 12 12 5 Ankyrin repeats (many copies) SprA-related PF12118.8 KPI89162.1 - 0.09 11.9 2.7 0.57 9.3 0.0 2.5 2 0 0 2 2 2 0 SprA-related family zf-B_box PF00643.24 KPI89163.1 - 0.0063 16.7 3.2 0.0063 16.7 3.2 2.8 2 1 0 2 2 2 1 B-box zinc finger DUF5401 PF17380.2 KPI89164.1 - 0.78 7.7 32.5 1.4 6.9 32.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5401) 2-Hacid_dh PF00389.30 KPI89164.1 - 7.5 6.2 7.0 19 4.9 7.0 1.7 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain CHCH PF06747.13 KPI89167.1 - 2.1e-06 27.7 1.9 3.4e-06 27.0 1.9 1.4 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 KPI89167.1 - 0.0082 16.1 0.8 0.017 15.1 0.8 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 KPI89167.1 - 0.027 14.2 2.1 0.046 13.5 2.1 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX17 PF05051.13 KPI89167.1 - 0.043 14.2 3.3 0.65 10.4 0.6 2.3 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) MTCP1 PF08991.10 KPI89167.1 - 0.095 12.9 1.1 0.16 12.2 1.1 1.4 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 KPI89167.1 - 0.11 12.8 2.7 0.31 11.4 2.7 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 KPI89167.1 - 0.17 11.9 4.1 8.9 6.4 4.2 2.2 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Actin PF00022.19 KPI89168.1 - 5.7e-81 272.2 0.0 9.6e-81 271.5 0.0 1.3 1 1 0 1 1 1 1 Actin Fcf1 PF04900.12 KPI89169.1 - 7.2e-31 106.5 2.6 7.2e-31 106.5 2.6 1.6 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 KPI89169.1 - 3.4e-13 49.9 0.2 6.7e-13 49.0 0.0 1.6 2 0 0 2 2 2 1 PIN like domain Thioredoxin PF00085.20 KPI89170.1 - 0.014 15.4 0.1 0.025 14.6 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin DUF2378 PF09536.10 KPI89171.1 - 0.029 14.2 0.5 3 7.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2378) RRM_1 PF00076.22 KPI89172.1 - 3.2e-12 46.1 0.0 1.2e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI89172.1 - 0.0024 17.4 0.0 0.0081 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SKA1 PF07160.12 KPI89172.1 - 0.0049 16.8 0.2 0.009 15.9 0.2 1.4 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 Nop10p PF04135.12 KPI89173.1 - 0.38 10.8 2.6 2 8.5 2.6 2.3 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family Pex2_Pex12 PF04757.14 KPI89174.1 - 3.5e-36 124.9 0.0 5.7e-36 124.2 0.0 1.3 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 KPI89174.1 - 0.0032 17.3 6.0 0.005 16.7 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI89174.1 - 0.14 12.0 6.0 0.23 11.3 6.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI89174.1 - 0.14 12.5 4.9 0.25 11.7 4.9 1.4 1 0 0 1 1 1 0 Ring finger domain Surp PF01805.20 KPI89175.1 - 1.3e-11 44.3 1.0 1.3e-11 44.3 1.0 1.8 2 0 0 2 2 2 1 Surp module Band_7 PF01145.25 KPI89176.1 - 6.6e-26 91.4 0.1 3.1e-25 89.2 0.0 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family RHH_4 PF13467.6 KPI89176.1 - 0.04 13.8 0.1 1 9.3 0.0 2.6 1 1 1 2 2 2 0 Ribbon-helix-helix domain Band_7_1 PF13421.6 KPI89176.1 - 0.12 12.0 0.8 0.24 11.1 0.0 1.8 2 1 0 2 2 2 0 SPFH domain-Band 7 family Band_7 PF01145.25 KPI89177.1 - 1e-22 81.0 0.0 1.7e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family 3HBOH PF10605.9 KPI89177.1 - 0.036 12.3 0.1 0.044 12.0 0.1 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) SET PF00856.28 KPI89181.1 - 1.9e-08 34.9 0.4 1.1e-07 32.4 0.0 2.4 2 1 1 3 3 3 1 SET domain GCV_T PF01571.21 KPI89182.1 - 1.6e-07 31.0 0.0 2.3e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Pkinase PF00069.25 KPI89183.1 - 4.9e-45 153.9 0.0 8.2e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89183.1 - 1.4e-27 96.6 0.0 3.3e-27 95.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.6 KPI89183.1 - 2.7e-08 33.4 0.4 1.3e-06 28.0 0.0 3.2 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 KPI89183.1 - 3.9e-08 33.5 2.1 0.00017 21.9 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) Kinase-like PF14531.6 KPI89183.1 - 0.00016 21.1 0.0 0.002 17.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like C1_2 PF03107.16 KPI89183.1 - 0.00023 21.4 3.8 0.00023 21.4 3.8 2.8 2 0 0 2 2 2 1 C1 domain LRR_1 PF00560.33 KPI89183.1 - 0.004 17.5 3.5 36 5.5 0.1 4.3 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 KPI89183.1 - 0.022 14.8 0.1 55 4.2 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LRR_9 PF14580.6 KPI89183.1 - 0.038 13.5 0.1 0.084 12.4 0.1 1.5 1 0 0 1 1 1 0 Leucine-rich repeat zf-B_box PF00643.24 KPI89183.1 - 0.055 13.6 17.9 0.56 10.4 5.0 2.5 2 0 0 2 2 2 0 B-box zinc finger ZZ PF00569.17 KPI89183.1 - 3.6 7.5 20.7 1.9 8.4 4.5 2.6 2 0 0 2 2 2 0 Zinc finger, ZZ type zf-CHY PF05495.12 KPI89183.1 - 4.5 7.8 13.5 27 5.3 12.8 2.6 1 1 0 1 1 1 0 CHY zinc finger zf-H2C2_5 PF13909.6 KPI89183.1 - 4.7 7.0 5.6 1.4 8.8 1.6 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain WD40 PF00400.32 KPI89184.1 - 5.9e-26 90.2 17.4 5.2e-07 30.3 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89184.1 - 3.5e-21 75.3 0.6 2.1e-06 27.9 0.0 6.1 3 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KPI89184.1 - 3.1e-07 30.5 0.0 0.072 13.0 0.0 3.5 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 KPI89184.1 - 0.00015 19.9 6.9 0.0019 16.3 0.1 2.8 3 0 0 3 3 3 2 IKI3 family Nbas_N PF15492.6 KPI89184.1 - 0.0066 15.8 0.0 0.19 11.0 0.0 2.6 3 0 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 KPI89184.1 - 0.08 11.9 0.0 2 7.3 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein UQ_con PF00179.26 KPI89185.1 - 4.3e-17 62.1 0.0 6.1e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KPI89185.1 - 0.00054 19.7 0.0 0.001 18.8 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B Clathrin-link PF09268.10 KPI89186.1 - 0.021 14.2 0.1 0.039 13.3 0.1 1.4 1 0 0 1 1 1 0 Clathrin, heavy-chain linker SET PF00856.28 KPI89187.1 - 1.9e-09 38.1 0.4 3.8e-09 37.1 0.4 1.5 1 1 0 1 1 1 1 SET domain TPR_1 PF00515.28 KPI89187.1 - 0.0012 18.6 0.6 0.0029 17.4 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-tcix PF14952.6 KPI89187.1 - 0.0013 18.3 0.3 0.0013 18.3 0.3 3.1 3 0 0 3 3 3 1 Putative treble-clef, zinc-finger, Zn-binding TPR_2 PF07719.17 KPI89187.1 - 0.089 12.9 0.1 0.36 11.0 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Ssl1 PF04056.14 KPI89188.1 - 4.4e-17 62.5 0.0 5e-08 33.0 0.0 2.2 1 1 1 2 2 2 2 Ssl1-like VWA_2 PF13519.6 KPI89188.1 - 5.6e-07 30.2 0.0 1.2e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Rubredoxin_2 PF18073.1 KPI89188.1 - 0.022 14.5 0.3 0.022 14.5 0.3 3.5 4 0 0 4 4 4 0 Rubredoxin metal binding domain zinc_ribbon_15 PF17032.5 KPI89188.1 - 1.6 9.5 8.3 2.8 8.7 2.5 2.5 2 0 0 2 2 2 0 zinc-ribbon family C1_4 PF07975.12 KPI89188.1 - 6.8 7.0 11.6 0.31 11.3 2.2 3.0 2 1 0 2 2 2 0 TFIIH C1-like domain Pterin_4a PF01329.19 KPI89189.1 - 0.06 13.5 0.2 1 9.6 0.0 2.9 2 2 1 3 3 3 0 Pterin 4 alpha carbinolamine dehydratase LMBR1 PF04791.16 KPI89189.1 - 0.68 8.8 2.0 0.82 8.5 2.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SpoU_methylase PF00588.19 KPI89190.1 - 3.3e-13 50.0 0.0 3e-11 43.7 0.0 2.5 2 1 0 2 2 2 1 SpoU rRNA Methylase family DUF4515 PF14988.6 KPI89191.1 - 3.7e-05 23.7 49.9 0.00027 20.9 28.1 3.6 1 1 1 3 3 3 3 Domain of unknown function (DUF4515) NAD_binding_4 PF07993.12 KPI89192.1 - 3.4e-66 223.1 0.0 4.8e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 KPI89192.1 - 3.5e-12 46.4 0.1 7.8e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 KPI89192.1 - 2.5e-07 30.4 0.2 3.5e-06 26.7 0.2 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KPI89192.1 - 4.4e-05 23.0 0.2 0.12 11.7 0.0 2.7 3 0 0 3 3 3 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KPI89192.1 - 0.0048 15.9 0.7 0.92 8.5 0.0 2.7 3 1 1 4 4 4 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KPI89192.1 - 0.052 12.6 2.8 0.51 9.4 0.0 3.0 4 0 0 4 4 4 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KPI89192.1 - 0.16 11.1 0.1 7.6 5.6 0.0 2.3 1 1 0 2 2 2 0 Polysaccharide biosynthesis protein FAD_binding_2 PF00890.24 KPI89193.1 - 3e-116 388.9 2.3 6.1e-116 387.9 1.1 1.8 2 0 0 2 2 2 1 FAD binding domain Succ_DH_flav_C PF02910.20 KPI89193.1 - 8.2e-41 139.0 0.4 1.2e-40 138.5 0.4 1.2 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 KPI89193.1 - 0.00054 19.3 0.1 0.0011 18.2 0.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KPI89193.1 - 0.0016 17.7 0.2 0.15 11.3 0.1 2.4 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 KPI89193.1 - 0.0073 15.9 0.4 0.043 13.4 0.4 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KPI89193.1 - 0.027 13.2 0.1 0.044 12.5 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 KPI89193.1 - 0.05 12.7 3.3 0.11 11.5 2.4 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 KPI89193.1 - 0.42 9.6 2.0 1.7 7.6 0.5 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 KPI89193.1 - 0.62 9.3 3.2 0.62 9.2 0.3 2.1 2 0 0 2 2 2 0 FAD binding domain GST_N_4 PF17172.4 KPI89194.1 - 0.0015 19.3 0.0 0.079 13.7 0.1 3.4 3 1 0 3 3 3 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 KPI89194.1 - 0.035 13.9 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain VirionAssem_T7 PF11653.8 KPI89194.1 - 4.5 7.9 7.5 1.3 9.6 1.9 2.6 2 0 0 2 2 2 0 Bacteriophage T7 virion assembly protein GST_N_4 PF17172.4 KPI89195.1 - 4.1e-16 59.5 0.0 1.1e-15 58.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 KPI89195.1 - 9.6e-10 38.8 0.0 2.1e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 KPI89195.1 - 4.3e-07 29.6 0.1 9e-07 28.6 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KPI89195.1 - 0.00015 21.7 0.2 0.00065 19.7 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain zf-rbx1 PF12678.7 KPI89196.1 - 1.8e-20 73.0 13.1 2.5e-20 72.5 13.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KPI89196.1 - 1.7e-12 47.2 7.6 2.2e-12 46.9 7.6 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KPI89196.1 - 1.3e-09 38.2 5.0 1.3e-09 38.2 5.0 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 KPI89196.1 - 1.7e-06 27.8 10.4 2.9e-05 23.9 10.4 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI89196.1 - 0.00011 21.9 7.3 0.00011 21.9 7.3 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KPI89196.1 - 0.00021 20.8 15.8 0.018 14.7 2.7 2.2 1 1 1 2 2 2 2 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 KPI89196.1 - 0.0011 18.8 3.8 0.0011 18.8 3.8 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KPI89196.1 - 0.014 15.2 16.9 6.4 6.6 16.9 2.4 1 1 0 1 1 1 0 RING-like zinc finger FANCL_C PF11793.8 KPI89196.1 - 0.02 15.1 9.8 0.041 14.1 9.8 1.5 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_5 PF14634.6 KPI89196.1 - 0.02 14.8 12.5 0.15 12.1 12.5 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KPI89196.1 - 0.027 14.5 12.4 0.15 12.1 12.4 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.8 KPI89196.1 - 0.17 11.7 4.3 0.43 10.4 4.3 1.7 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit GST_N_4 PF17172.4 KPI89197.1 - 1.2e-13 51.7 0.0 1.2e-12 48.4 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 KPI89197.1 - 5.1e-10 39.7 0.0 1.3e-08 35.2 0.0 2.4 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 KPI89197.1 - 1.6e-05 24.6 0.1 3.3e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Orthoreo_P17 PF07272.11 KPI89197.1 - 0.034 14.1 1.9 0.66 10.0 0.2 2.3 2 0 0 2 2 2 0 Orthoreovirus P17 protein GST_C_2 PF13410.6 KPI89197.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KPI89198.1 - 4.2e-21 75.6 0.0 8.3e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 KPI89198.1 - 7.5e-11 42.4 0.0 1.3e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 KPI89198.1 - 2.5e-09 36.8 0.0 6.4e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KPI89198.1 - 1.9e-06 27.8 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KPI89198.1 - 0.00022 21.6 0.0 0.0005 20.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KPI89198.1 - 0.085 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KPI89198.1 - 0.12 12.7 0.0 0.36 11.2 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain CUE PF02845.16 KPI89200.1 - 0.0032 17.1 0.0 0.0057 16.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF1751 PF08551.10 KPI89200.1 - 0.11 13.1 0.2 0.11 13.1 0.2 2.1 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 KPI89200.1 - 0.12 12.3 5.0 0.027 14.5 1.2 1.8 2 0 0 2 2 2 0 Rhomboid family RRM_1 PF00076.22 KPI89203.1 - 1.2e-28 98.7 0.0 8e-19 67.2 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI89203.1 - 0.0015 18.6 0.0 0.75 10.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 KPI89203.1 - 0.017 14.7 0.0 0.053 13.1 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI89203.1 - 0.024 14.6 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KPI89203.1 - 0.32 11.2 1.8 20 5.4 0.0 3.2 4 0 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter LRR_6 PF13516.6 KPI89204.1 - 7.8e-05 22.4 2.4 0.042 13.9 0.0 3.6 3 0 0 3 3 3 2 Leucine Rich repeat Clat_adaptor_s PF01217.20 KPI89206.1 - 1.3e-43 148.3 0.5 1.5e-43 148.1 0.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SPO22 PF08631.10 KPI89206.1 - 0.087 12.3 0.5 0.99 8.8 0.2 1.9 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like RecQ_Zn_bind PF16124.5 KPI89207.1 - 9.7e-16 58.3 1.2 2.9e-15 56.7 1.2 1.9 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.31 KPI89207.1 - 2.3e-14 53.7 0.0 6e-13 49.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI89207.1 - 8.6e-14 51.7 0.0 2.1e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase HRDC PF00570.23 KPI89207.1 - 0.0002 21.3 0.0 0.00049 20.0 0.0 1.7 1 0 0 1 1 1 1 HRDC domain ERCC4 PF02732.15 KPI89208.1 - 2.4e-14 53.8 0.0 5e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain SAP PF02037.27 KPI89208.1 - 9.1e-07 28.5 0.3 9.1e-07 28.5 0.3 1.9 2 0 0 2 2 2 1 SAP domain TCTP PF00838.17 KPI89209.1 - 1.1e-43 149.5 1.3 1.2e-43 149.3 1.3 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein UPF0262 PF06793.12 KPI89209.1 - 0.1 12.7 0.1 0.13 12.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) DUF273 PF03314.14 KPI89209.1 - 0.1 12.2 0.4 2.1 7.9 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF273 WD40 PF00400.32 KPI89210.1 - 3.3e-09 37.2 0.6 0.0024 18.7 0.0 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89210.1 - 0.0015 18.8 0.0 0.22 11.8 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain FYDLN_acid PF09538.10 KPI89210.1 - 0.42 11.3 6.5 0.74 10.5 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) START PF01852.19 KPI89211.1 - 0.001 18.6 0.0 0.86 9.0 0.0 2.9 3 0 0 3 3 3 2 START domain WD40 PF00400.32 KPI89212.1 - 0.00086 20.1 0.0 0.072 14.0 0.0 3.6 2 0 0 2 2 2 1 WD domain, G-beta repeat ABC_tran PF00005.27 KPI89214.1 - 1.5e-26 93.6 0.0 1.2e-10 42.0 0.0 5.1 5 0 0 5 5 5 4 ABC transporter ABC_membrane PF00664.23 KPI89214.1 - 8e-20 71.6 21.4 2.5e-13 50.3 10.0 2.9 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_16 PF13191.6 KPI89214.1 - 0.02 15.3 0.1 0.19 12.1 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 KPI89214.1 - 0.028 14.3 0.1 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase T2SSE PF00437.20 KPI89214.1 - 0.03 13.4 0.0 0.41 9.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 KPI89214.1 - 0.04 13.7 0.0 0.44 10.3 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KPI89214.1 - 0.094 12.8 0.3 15 5.7 0.0 2.8 3 0 0 3 3 3 0 50S ribosome-binding GTPase DUF2075 PF09848.9 KPI89214.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Ribonuclease_3 PF00636.26 KPI89216.1 - 0.033 14.8 0.0 1.2 9.8 0.0 2.7 1 1 0 1 1 1 0 Ribonuclease III domain Pkinase PF00069.25 KPI89217.1 - 1.2e-50 172.4 0.0 1.8e-50 171.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89217.1 - 3.8e-32 111.6 0.0 6.6e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase AA_permease_2 PF13520.6 KPI89217.1 - 0.0062 15.4 4.3 0.021 13.7 1.6 2.1 2 0 0 2 2 2 1 Amino acid permease APH PF01636.23 KPI89217.1 - 0.015 15.2 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI89217.1 - 0.095 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 KPI89217.1 - 0.11 11.2 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase AlbA_2 PF04326.14 KPI89218.1 - 0.002 18.4 0.0 0.0045 17.3 0.0 1.6 1 0 0 1 1 1 1 Putative DNA-binding domain Pkinase PF00069.25 KPI89219.1 - 4.2e-73 246.0 0.0 6.2e-73 245.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89219.1 - 7.3e-39 133.6 0.0 1.2e-38 132.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89219.1 - 2e-06 27.4 0.0 6.2e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KPI89219.1 - 0.0015 17.9 0.1 0.0049 16.3 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KPI89219.1 - 0.012 15.2 0.1 0.032 13.8 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.23 KPI89219.1 - 0.054 13.4 0.0 1.7 8.5 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family eIF-6 PF01912.18 KPI89220.1 - 1.9e-80 268.9 0.5 2.4e-80 268.6 0.2 1.3 2 0 0 2 2 2 1 eIF-6 family Glyco_trans_1_4 PF13692.6 KPI89220.1 - 0.054 13.9 0.1 1.1 9.6 0.0 2.7 2 1 1 3 3 3 0 Glycosyl transferases group 1 NifU PF01106.17 KPI89221.1 - 1.5e-24 85.9 0.1 2.4e-24 85.3 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 KPI89221.1 - 1.9e-08 34.2 0.0 4.2e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal DUF3764 PF12594.8 KPI89221.1 - 0.095 12.8 0.0 2.8 8.1 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3764) HA2 PF04408.23 KPI89222.1 - 6.6e-17 61.8 0.3 2e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI89222.1 - 2.7e-16 59.9 0.0 1.2e-15 57.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI89222.1 - 4.1e-08 33.2 0.1 1.1e-07 31.8 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 KPI89222.1 - 2.2e-07 31.1 0.0 6.9e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 KPI89222.1 - 0.00034 20.9 0.1 0.0017 18.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 KPI89222.1 - 0.0016 17.6 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 KPI89222.1 - 0.088 13.0 0.0 0.36 11.0 0.0 2.1 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KPI89222.1 - 0.098 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.6 KPI89222.1 - 0.1 12.3 0.0 5.3 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KPI89222.1 - 0.15 11.7 0.3 3.7 7.1 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 KPI89222.1 - 0.2 11.1 0.0 0.47 9.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase PF00069.25 KPI89223.1 - 1.4e-54 185.2 0.0 1.9e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89223.1 - 1.7e-30 106.2 0.0 2.5e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI89223.1 - 0.0066 15.3 0.0 0.01 14.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase C2 PF00168.30 KPI89224.1 - 0.13 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 C2 domain SlyX PF04102.12 KPI89224.1 - 1.2 9.8 16.8 3.7 8.2 6.5 3.2 2 1 1 3 3 3 0 SlyX Prominin PF05478.11 KPI89224.1 - 1.2 7.0 2.4 1.9 6.4 2.4 1.3 1 0 0 1 1 1 0 Prominin TMF_TATA_bd PF12325.8 KPI89224.1 - 3.8 7.8 10.1 2.4 8.4 0.6 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding PRKG1_interact PF15898.5 KPI89224.1 - 6.5 7.7 11.6 11 6.9 10.3 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain zf-CCCH PF00642.24 KPI89225.1 - 0.00012 21.9 1.1 0.6 10.1 0.1 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KPI89225.1 - 0.00012 22.7 6.7 0.0083 16.8 0.2 3.3 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 KPI89225.1 - 1.2 9.2 9.0 0.16 12.1 1.2 2.7 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_4 PF18044.1 KPI89225.1 - 9.8 6.1 11.7 1.4 8.8 0.4 3.3 3 0 0 3 3 3 0 CCCH-type zinc finger cNMP_binding PF00027.29 KPI89226.1 - 5.8e-18 64.8 0.0 9.2e-09 35.3 0.1 5.1 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain C2 PF00168.30 KPI89226.1 - 7e-11 42.3 0.0 0.00052 20.3 0.0 4.5 4 0 0 4 4 4 3 C2 domain Arf PF00025.21 KPI89227.1 - 3.4e-31 108.0 0.0 4.7e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KPI89227.1 - 1.2e-09 37.8 0.0 5.2e-09 35.7 0.0 1.8 1 1 1 2 2 2 1 G-protein alpha subunit Ras PF00071.22 KPI89227.1 - 3.3e-09 36.5 0.0 4.3e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI89227.1 - 1.3e-08 35.0 0.0 2.3e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KPI89227.1 - 3e-07 30.1 0.0 4.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KPI89227.1 - 0.0042 16.6 0.0 0.0069 15.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF5582 PF17819.1 KPI89227.1 - 0.11 13.0 0.1 0.26 11.7 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5582) Tfb2 PF03849.14 KPI89229.1 - 3.1e-23 82.3 0.0 4.6e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.6 KPI89229.1 - 3.6e-05 23.9 0.4 0.00019 21.6 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HECW1_helix PF18436.1 KPI89229.1 - 0.031 14.4 0.3 10 6.3 0.0 3.0 3 0 0 3 3 3 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 Cation_efflux PF01545.21 KPI89231.1 - 2.5e-43 148.2 3.1 3.3e-43 147.7 3.1 1.2 1 0 0 1 1 1 1 Cation efflux family Peptidase_C2 PF00648.21 KPI89232.1 - 1.4e-23 83.4 0.0 2.3e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Rrp15p PF07890.12 KPI89232.1 - 0.13 12.6 3.3 0.25 11.7 3.3 1.4 1 0 0 1 1 1 0 Rrp15p PEHE PF15275.6 KPI89233.1 - 0.083 13.5 0.1 0.083 13.5 0.1 2.4 2 1 0 2 2 2 0 PEHE domain TPR_1 PF00515.28 KPI89234.1 - 1.7e-14 52.9 2.4 0.0028 17.4 0.1 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI89234.1 - 2.6e-11 42.7 26.2 0.0019 18.2 0.1 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI89234.1 - 1.6e-09 37.3 10.8 0.0051 16.5 0.0 5.3 6 0 0 6 6 6 3 TPR repeat DnaJ PF00226.31 KPI89234.1 - 9.8e-09 35.2 0.0 3.2e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_12 PF13424.6 KPI89234.1 - 0.0017 18.6 3.1 0.0017 18.6 3.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 KPI89234.1 - 0.002 18.3 19.2 0.55 10.4 0.2 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89234.1 - 0.042 14.7 34.2 0.37 11.7 0.3 8.2 5 2 3 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89234.1 - 0.042 13.9 3.0 7.2 6.9 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89234.1 - 1.4 9.3 12.1 34 5.0 0.1 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat XPC-binding PF09280.11 KPI89235.1 - 0.0028 17.4 0.0 0.011 15.5 0.0 2.0 2 0 0 2 2 2 1 XPC-binding domain Torus PF16131.5 KPI89236.1 - 3.1e-05 24.6 0.1 3.1e-05 24.6 0.1 4.0 6 0 0 6 6 6 1 Torus domain zf-CCCH_4 PF18044.1 KPI89236.1 - 0.00095 18.9 1.8 0.0026 17.5 1.8 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI89236.1 - 0.0075 16.3 1.2 0.0075 16.3 1.2 2.8 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH PF00642.24 KPI89236.1 - 0.043 13.7 7.9 0.44 10.5 1.1 3.2 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KPI89237.1 - 6.8e-06 26.7 6.8 0.00035 21.2 0.1 2.9 3 0 0 3 3 3 2 Torus domain zf-CCCH PF00642.24 KPI89237.1 - 3.9e-05 23.4 16.6 0.00056 19.7 0.3 3.3 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KPI89237.1 - 0.00015 21.5 14.4 0.013 15.3 3.8 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI89237.1 - 0.0061 16.6 1.4 0.0061 16.6 1.4 3.8 4 0 0 4 4 4 2 Zinc finger domain Pkinase PF00069.25 KPI89238.1 - 1.1e-69 234.7 0.0 1.3e-69 234.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89238.1 - 2e-34 119.1 0.0 2.7e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89238.1 - 0.00012 21.5 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI89238.1 - 0.0008 18.8 1.9 0.0014 18.0 1.9 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI89238.1 - 0.011 14.7 2.3 0.033 13.1 2.3 1.7 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KPI89238.1 - 0.096 12.6 0.1 0.096 12.6 0.1 1.8 2 1 0 2 2 2 0 Phosphotransferase enzyme family LRR_9 PF14580.6 KPI89239.1 - 2.7e-13 49.8 3.4 5.4e-12 45.6 1.1 2.9 2 1 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 KPI89239.1 - 7.5e-12 45.3 0.6 0.00018 21.8 0.0 2.9 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI89239.1 - 2.5e-10 39.9 6.2 2.4e-06 27.2 0.7 2.9 2 1 1 3 3 3 2 Leucine rich repeat SSB PF00436.25 KPI89240.1 - 1.8e-05 24.7 0.0 2.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family tRNA_anti-codon PF01336.25 KPI89240.1 - 0.073 13.1 0.1 0.22 11.5 0.1 1.9 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain EamA PF00892.20 KPI89243.1 - 2e-06 28.0 33.8 0.0016 18.6 9.5 4.3 3 2 1 4 4 4 3 EamA-like transporter family CRT-like PF08627.10 KPI89243.1 - 0.0082 15.1 13.4 0.035 13.0 13.4 1.8 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like PIG-U PF06728.13 KPI89245.1 - 4.2e-05 22.8 20.1 0.0043 16.2 20.1 2.4 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U RNase_HII PF01351.18 KPI89246.1 - 3.2e-44 151.2 0.0 4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII DUF3592 PF12158.8 KPI89247.1 - 1.7e-16 60.6 0.3 1.9e-16 60.4 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3592) ATP-synt_Eps PF04627.13 KPI89248.1 - 2.9e-07 30.4 0.8 3.1e-07 30.3 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial ATP synthase epsilon chain DnaJ PF00226.31 KPI89249.1 - 2.2e-21 75.8 0.3 4e-21 74.9 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1522 PF07482.11 KPI89249.1 - 0.078 13.3 9.4 0.11 12.8 0.3 2.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1522) DALR_2 PF09190.11 KPI89249.1 - 0.12 12.8 2.5 15 6.1 0.3 3.4 2 1 0 2 2 2 0 DALR domain Kringle PF00051.18 KPI89251.1 - 9.8e-19 67.5 1.1 1.9e-18 66.6 1.1 1.5 1 0 0 1 1 1 1 Kringle domain CHB_HEX_C_1 PF13290.6 KPI89251.1 - 0.0026 17.7 0.3 0.058 13.4 0.0 3.1 2 0 0 2 2 2 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 KPI89251.1 - 0.0061 16.7 0.5 0.11 12.7 0.0 2.9 3 0 0 3 3 3 1 Fn3 associated NdhO PF11910.8 KPI89251.1 - 0.02 15.1 0.1 0.81 9.9 0.0 2.6 2 0 0 2 2 2 0 Cyanobacterial and plant NDH-1 subunit O SEC-C PF02810.15 KPI89253.1 - 0.00018 21.3 3.2 0.00032 20.6 3.2 1.3 1 0 0 1 1 1 1 SEC-C motif MMR_HSR1 PF01926.23 KPI89254.1 - 1.8e-12 47.3 0.0 2.9e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI89254.1 - 2e-07 30.7 0.0 7.6e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KPI89254.1 - 1.5e-05 25.0 0.1 5.2e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KPI89254.1 - 0.0024 18.0 0.5 0.4 10.7 0.1 2.4 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 KPI89254.1 - 0.0062 16.0 0.0 0.0099 15.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KPI89254.1 - 0.0078 15.8 0.0 0.35 10.4 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KPI89254.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_28 PF13521.6 KPI89254.1 - 0.23 11.7 1.1 2.5 8.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain TFIIB PF00382.19 KPI89255.1 - 4e-24 84.5 0.6 1.4e-12 47.5 0.0 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 KPI89255.1 - 0.00039 19.9 0.0 0.001 18.5 0.0 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_Tnp_ISL3 PF13542.6 KPI89255.1 - 0.15 11.5 0.2 0.89 9.0 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 WD40 PF00400.32 KPI89256.1 - 3.7e-35 119.4 25.8 6.2e-08 33.2 0.7 9.3 10 0 0 10 10 10 7 WD domain, G-beta repeat Utp13 PF08625.11 KPI89256.1 - 9.4e-35 119.6 0.7 1.7e-34 118.8 0.7 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 KPI89256.1 - 6.1e-16 58.5 6.6 3.4e-06 27.3 0.0 6.4 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI89256.1 - 5.3e-06 25.6 2.2 2.7 6.9 0.0 4.8 4 1 2 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KPI89256.1 - 0.00099 18.5 0.3 1.3 8.3 0.0 3.8 4 1 0 4 4 4 2 WD40-like domain PHTB1_N PF14727.6 KPI89256.1 - 0.026 13.9 0.9 1.2 8.4 0.1 2.6 3 0 0 3 3 3 0 PTHB1 N-terminus Nup160 PF11715.8 KPI89256.1 - 0.071 11.7 5.3 8.8 4.8 0.2 4.1 3 2 1 4 4 4 0 Nucleoporin Nup120/160 Apolipoprotein PF01442.18 KPI89257.1 - 0.002 18.0 25.4 0.002 18.0 25.4 5.8 3 2 2 5 5 5 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 KPI89257.1 - 0.0045 17.1 7.9 0.0045 17.1 7.9 5.1 3 2 3 6 6 6 1 Apolipophorin-III precursor (apoLp-III) HSBP1 PF06825.12 KPI89257.1 - 0.018 14.9 4.8 0.29 11.0 0.4 3.4 3 0 0 3 3 3 0 Heat shock factor binding protein 1 Pox_A_type_inc PF04508.12 KPI89257.1 - 0.4 10.6 2.4 1.4 8.8 2.4 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat ING PF12998.7 KPI89257.1 - 0.61 10.7 0.0 0.61 10.7 0.0 4.7 3 1 1 6 6 6 0 Inhibitor of growth proteins N-terminal histone-binding Sec20 PF03908.13 KPI89257.1 - 2.1 8.3 7.4 0.17 11.8 0.4 2.9 3 0 0 3 3 3 0 Sec20 SUI1 PF01253.22 KPI89258.1 - 2.5e-16 60.0 0.0 5.7e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 XkdW PF09636.10 KPI89261.1 - 0.63 10.1 3.6 1.1 9.4 0.3 3.1 2 0 0 2 2 2 0 XkdW protein BRI3BP PF14965.6 KPI89261.1 - 0.98 8.9 3.7 0.61 9.6 0.1 2.5 3 0 0 3 3 3 0 Negative regulator of p53/TP53 Fcf2 PF08698.11 KPI89262.1 - 1.6e-06 28.4 7.2 5.3e-06 26.7 6.8 2.2 1 1 0 1 1 1 1 Fcf2 pre-rRNA processing Hydrolase_2 PF07486.12 KPI89262.1 - 0.0069 17.2 4.9 0.54 11.1 2.1 2.1 2 0 0 2 2 2 2 Cell Wall Hydrolase SAPS PF04499.15 KPI89262.1 - 0.055 12.3 3.0 0.069 11.9 3.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Phage_tail_APC PF16778.5 KPI89262.1 - 0.15 12.0 0.7 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 Phage tail assembly chaperone protein DUF1308 PF07000.11 KPI89264.1 - 7.8e-19 68.2 0.1 7.1e-13 48.8 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1308) GLTSCR1 PF15249.6 KPI89264.1 - 0.0064 16.9 0.3 0.017 15.5 0.3 1.7 1 0 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein DUF89 PF01937.19 KPI89264.1 - 0.028 13.4 0.0 0.046 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 zf-RING_2 PF13639.6 KPI89265.1 - 5.8e-10 39.3 12.6 2.8e-09 37.1 12.6 2.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KPI89265.1 - 2.3e-06 27.8 7.5 1.1e-05 25.6 7.5 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KPI89265.1 - 4.4e-06 26.3 11.1 1.3e-05 24.8 11.1 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 KPI89265.1 - 5.8e-05 23.0 10.0 5.8e-05 23.0 10.0 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-Nse PF11789.8 KPI89265.1 - 0.00024 20.8 6.6 0.0023 17.7 5.7 2.6 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 KPI89265.1 - 0.00028 20.9 5.3 0.0013 18.8 5.3 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 KPI89265.1 - 0.00043 20.1 12.7 0.0028 17.5 12.7 2.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI89265.1 - 0.0027 17.5 11.9 0.015 15.1 11.9 2.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 KPI89265.1 - 0.84 9.9 6.9 2.8 8.2 6.9 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 KPI89265.1 - 1.2 9.0 13.7 0.52 10.2 9.7 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.28 KPI89266.1 - 0.00024 21.2 0.0 0.00061 19.9 0.0 1.6 1 0 0 1 1 1 1 SPRY domain B9-C2 PF07162.11 KPI89267.1 - 3.1e-44 151.1 0.2 3.5e-44 151.0 0.2 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein BRCT_2 PF16589.5 KPI89268.1 - 6.2e-07 29.7 0.0 0.016 15.6 0.0 2.5 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KPI89268.1 - 0.12 12.7 0.0 22 5.4 0.0 2.4 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain BRCT PF00533.26 KPI89268.1 - 0.13 12.7 0.0 1 9.8 0.0 2.2 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Diphthami_syn_2 PF01902.17 KPI89270.1 - 1.6e-26 93.2 0.0 4.8e-25 88.4 0.0 2.6 1 1 0 1 1 1 1 Diphthamide synthase RRM_1 PF00076.22 KPI89271.1 - 2.5e-05 24.0 0.0 0.014 15.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Seryl_tRNA_N PF02403.22 KPI89273.1 - 0.0016 18.7 0.2 0.0016 18.7 0.2 6.7 5 2 2 7 7 7 1 Seryl-tRNA synthetase N-terminal domain YabA PF06156.13 KPI89273.1 - 0.033 14.8 0.3 0.033 14.8 0.3 7.5 7 2 0 8 8 8 0 Initiation control protein YabA Dynein_light PF01221.18 KPI89274.1 - 3.3e-34 117.1 0.4 3.6e-34 116.9 0.4 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 N_NLPC_P60 PF12912.7 KPI89274.1 - 0.076 13.4 0.0 0.083 13.3 0.0 1.1 1 0 0 1 1 1 0 NLPC_P60 stabilising domain, N term ATXN-1_C PF12547.8 KPI89275.1 - 2.2 8.7 7.9 15 6.0 0.3 3.4 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator Tho2 PF11262.8 KPI89275.1 - 5.8 6.0 14.5 3 7.0 4.9 2.5 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 CTK3_C PF12350.8 KPI89275.1 - 7.4 6.8 9.6 0.19 11.9 2.5 2.1 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus Bud13 PF09736.9 KPI89276.1 - 3.2e-07 30.9 0.1 9.4e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex DSPc PF00782.20 KPI89277.1 - 5.2e-15 55.4 0.0 8.1e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 KPI89277.1 - 0.0026 17.4 0.1 0.0042 16.8 0.1 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 KPI89277.1 - 0.016 15.2 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 KPI89277.1 - 0.071 12.7 0.8 0.095 12.3 0.8 1.4 1 1 0 1 1 1 0 Protein-tyrosine phosphatase GRP PF07172.11 KPI89278.1 - 0.01 16.5 3.8 0.01 16.5 3.8 2.0 2 0 0 2 2 2 1 Glycine rich protein family GAGA PF09237.11 KPI89278.1 - 0.12 12.3 0.3 0.31 10.9 0.3 1.7 1 0 0 1 1 1 0 GAGA factor SyrA PF11089.8 KPI89278.1 - 0.12 12.4 2.3 0.23 11.6 2.3 1.3 1 0 0 1 1 1 0 Exopolysaccharide production repressor Spt5_N PF11942.8 KPI89278.1 - 1.9 9.5 9.6 0.83 10.7 1.1 2.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Mito_carr PF00153.27 KPI89279.1 - 9.1e-60 198.6 0.2 6.1e-21 74.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KPI89279.1 - 0.14 11.3 0.1 16 4.5 0.0 3.0 3 0 0 3 3 3 0 Gammaproteobacterial serine protease WD40_3 PF15911.5 KPI89280.1 - 3.2e-15 55.9 0.0 6.7e-14 51.6 0.0 2.7 1 1 1 2 2 2 1 WD domain, G-beta repeat Clathrin PF00637.20 KPI89280.1 - 2.5e-09 37.1 3.7 9.2e-06 25.6 0.2 4.3 3 1 1 4 4 4 1 Region in Clathrin and VPS ANAPC3 PF12895.7 KPI89280.1 - 0.00099 19.3 11.7 0.048 13.9 3.4 4.9 3 2 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 ANAPC4_WD40 PF12894.7 KPI89280.1 - 0.0023 18.2 0.3 0.87 9.9 0.0 4.1 1 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_19 PF14559.6 KPI89280.1 - 0.0027 18.2 10.1 0.18 12.4 0.0 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89280.1 - 0.21 11.7 9.4 0.33 11.1 0.2 5.5 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89280.1 - 0.22 12.5 9.7 47 5.2 0.3 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat MIT PF04212.18 KPI89280.1 - 0.6 10.2 10.7 1.9 8.6 1.0 4.0 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Coatomer_WDAD PF04053.14 KPI89280.1 - 2.1 7.3 7.2 14 4.6 1.0 4.3 4 1 1 5 5 5 0 Coatomer WD associated region DZR PF12773.7 KPI89280.1 - 2.2 8.4 6.4 11 6.1 6.4 2.2 1 1 0 1 1 1 0 Double zinc ribbon TPR_12 PF13424.6 KPI89280.1 - 6.3 7.2 14.2 39 4.6 0.0 6.2 7 0 0 7 7 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KPI89280.1 - 8 6.5 8.2 22 5.0 0.1 3.7 4 0 0 4 4 4 0 Mad3/BUB1 homology region 1 Peptidase_C12 PF01088.21 KPI89281.1 - 4.1e-54 183.5 0.0 4.7e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Enolase_N PF03952.16 KPI89281.1 - 0.0079 16.4 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain AAA_lid_7 PF17867.1 KPI89282.1 - 0.021 15.0 0.0 0.096 12.9 0.0 2.1 1 0 0 1 1 1 0 Midasin AAA lid domain Lactamase_B_6 PF16661.5 KPI89283.1 - 1.1e-18 67.4 0.0 1.7e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 KPI89283.1 - 1.6e-14 54.4 4.0 2.8e-14 53.7 0.1 2.9 2 1 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Lactamase_B_2 PF12706.7 KPI89283.1 - 4.1e-05 23.2 0.0 0.00011 21.8 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KPI89283.1 - 0.0086 16.1 0.1 0.02 14.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Beta-Casp PF10996.8 KPI89283.1 - 0.067 13.5 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Beta-Casp domain Sporozoite_P67 PF05642.11 KPI89283.1 - 0.11 10.6 0.0 0.16 10.1 0.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BBP1_C PF15272.6 KPI89284.1 - 0.019 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal KLRAQ PF10205.9 KPI89284.1 - 0.034 14.4 0.6 2.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein AcetDehyd-dimer PF09290.11 KPI89284.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.6 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation Cep57_MT_bd PF06657.13 KPI89284.1 - 0.13 12.7 1.6 0.56 10.7 0.1 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 ZapB PF06005.12 KPI89284.1 - 0.46 11.0 0.0 0.46 11.0 0.0 2.4 2 1 0 2 2 2 0 Cell division protein ZapB HALZ PF02183.18 KPI89284.1 - 3 8.1 4.9 33 4.8 0.1 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper RNA_pol_Rpb6 PF01192.22 KPI89286.1 - 4.3e-09 36.2 0.0 8.9e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb6 GTP_EFTU PF00009.27 KPI89287.1 - 3.3e-50 170.3 0.1 5.3e-50 169.7 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KPI89287.1 - 1.5e-15 57.0 0.0 4.4e-15 55.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus Septin PF00735.18 KPI89287.1 - 2e-05 24.0 0.1 3.3e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KPI89287.1 - 3.1e-05 24.0 0.1 7.8e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 KPI89287.1 - 0.001 19.4 0.1 0.0028 18.0 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KPI89287.1 - 0.0031 17.6 0.0 0.008 16.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II ETF PF01012.21 KPI89288.1 - 6e-45 153.3 4.0 8.1e-45 152.9 4.0 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain PIG-L PF02585.17 KPI89288.1 - 0.0061 17.2 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Y_Y_Y PF07495.13 KPI89288.1 - 0.17 11.9 0.2 0.78 9.7 0.1 1.9 2 0 0 2 2 2 0 Y_Y_Y domain CrgA PF06781.12 KPI89290.1 - 0.0054 16.8 0.1 0.0065 16.5 0.1 1.1 1 0 0 1 1 1 1 Cell division protein CrgA DotU PF09850.9 KPI89290.1 - 0.061 13.0 0.1 0.066 12.9 0.1 1.0 1 0 0 1 1 1 0 Type VI secretion system protein DotU RPAP1_N PF08621.10 KPI89292.1 - 0.0064 16.2 3.5 0.4 10.5 0.4 2.2 2 0 0 2 2 2 2 RPAP1-like, N-terminal DUF745 PF05335.13 KPI89292.1 - 0.042 13.6 0.9 0.054 13.2 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF2976 PF11190.8 KPI89292.1 - 0.078 12.8 0.5 0.14 11.9 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) DUF883 PF05957.13 KPI89292.1 - 0.089 13.4 0.2 0.18 12.4 0.2 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Sec20 PF03908.13 KPI89292.1 - 0.33 10.9 1.7 1.5 8.8 1.7 1.8 1 1 0 1 1 1 0 Sec20 HemY_N PF07219.13 KPI89292.1 - 4.1 7.7 6.0 0.73 10.1 0.8 2.0 2 0 0 2 2 2 0 HemY protein N-terminus RRM_1 PF00076.22 KPI89294.1 - 1.2e-67 223.6 0.4 2.9e-20 71.8 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KPI89294.1 - 4.3e-20 71.7 0.4 9.7e-20 70.5 0.4 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 KPI89294.1 - 1e-07 31.7 0.1 0.011 15.6 0.0 4.3 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_7 PF16367.5 KPI89294.1 - 1.8e-06 27.9 0.0 0.25 11.5 0.0 4.9 4 2 0 4 4 4 2 RNA recognition motif DUF4140 PF13600.6 KPI89294.1 - 0.12 12.9 0.2 2.3 8.7 0.0 2.7 2 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Got1 PF04178.12 KPI89297.1 - 2.6e-26 92.2 15.7 3.3e-26 91.9 15.7 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF4227 PF14004.6 KPI89297.1 - 1.7 8.7 6.6 1.4 9.0 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) DUF2070 PF09843.9 KPI89297.1 - 2.9 6.1 9.3 3.9 5.6 9.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CEP44 PF15007.6 KPI89298.1 - 1.3e-05 25.3 0.0 1.7e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 M PF02370.16 KPI89299.1 - 0.13 12.9 1.4 0.54 11.0 1.4 2.2 1 0 0 1 1 1 0 M protein repeat YabA PF06156.13 KPI89299.1 - 0.72 10.5 11.7 0.11 13.2 0.9 3.8 3 1 1 4 4 4 0 Initiation control protein YabA TSC22 PF01166.18 KPI89299.1 - 3.7 7.9 8.8 0.35 11.2 1.4 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF2431 PF10354.9 KPI89300.1 - 1.6e-17 64.3 0.0 2e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) COX_ARM PF06481.14 KPI89300.1 - 0.13 12.2 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 COX Aromatic Rich Motif zf-C2H2 PF00096.26 KPI89302.1 - 3.7e-06 27.1 12.8 0.21 12.1 2.0 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KPI89302.1 - 0.00026 21.2 14.5 0.0098 16.2 0.1 4.2 3 2 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KPI89302.1 - 0.00039 21.0 11.1 1 10.4 0.3 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KPI89302.1 - 0.0099 16.2 0.1 0.0099 16.2 0.1 4.6 4 1 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KPI89302.1 - 0.029 14.7 6.5 1.2 9.5 0.3 3.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) PNP_UDP_1 PF01048.20 KPI89302.1 - 0.12 11.6 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Phosphorylase superfamily DZR PF12773.7 KPI89302.1 - 0.21 11.7 5.8 0.19 11.8 2.9 2.0 2 0 0 2 2 2 0 Double zinc ribbon zf-C2H2_3 PF13878.6 KPI89302.1 - 0.51 10.2 6.9 2.7 7.9 0.3 3.1 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO FR47 PF08445.10 KPI89303.1 - 1.9e-06 27.8 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 KPI89303.1 - 4.8e-06 26.5 0.1 6.3e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KPI89303.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KPI89303.1 - 0.002 18.5 0.1 0.0041 17.5 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Glycos_transf_2 PF00535.26 KPI89304.1 - 0.00012 21.9 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF5410 PF17422.2 KPI89304.1 - 0.23 10.7 0.0 0.35 10.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5410) GlgX_C PF18390.1 KPI89305.1 - 0.013 15.2 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme C-terminal domain Fucokinase PF07959.12 KPI89306.1 - 3.6e-22 78.9 0.0 5e-20 71.8 0.0 2.7 1 1 0 1 1 1 1 L-fucokinase GHMP_kinases_N PF00288.26 KPI89306.1 - 0.00013 22.2 0.0 0.00047 20.3 0.0 2.1 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KPI89306.1 - 0.024 15.0 0.0 0.073 13.4 0.0 1.8 1 0 0 1 1 1 0 GHMP kinases C terminal Pyridoxal_deC PF00282.19 KPI89308.1 - 6.8e-17 61.2 0.0 8.6e-12 44.5 0.0 2.3 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain TetR_C_11 PF16859.5 KPI89308.1 - 0.02 15.2 2.4 0.047 14.0 1.7 2.1 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Aminotran_5 PF00266.19 KPI89308.1 - 0.055 12.4 0.0 0.088 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V CAML PF14963.6 KPI89309.1 - 3.6 7.6 5.5 0.42 10.7 0.5 1.9 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand fn3 PF00041.21 KPI89310.1 - 0.011 16.1 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type III domain XRN_N PF03159.18 KPI89311.1 - 1.4e-21 77.1 4.1 8.5e-19 67.9 0.0 3.8 3 1 0 3 3 3 2 XRN 5'-3' exonuclease N-terminus DUF3652 PF12372.8 KPI89311.1 - 0.27 11.2 0.9 0.54 10.2 0.1 1.9 2 0 0 2 2 2 0 Huntingtin protein region TTL PF03133.15 KPI89312.1 - 1.1e-75 254.6 0.0 8.8e-75 251.6 0.0 2.4 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KPI89312.1 - 1.2e-05 24.7 0.0 0.028 13.7 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 KPI89312.1 - 1.7e-05 24.2 0.0 0.061 12.6 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp Beta_helix PF13229.6 KPI89313.1 - 0.077 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Right handed beta helix region PikAIV_N PF18605.1 KPI89313.1 - 0.082 12.5 0.8 1.2 8.7 0.3 2.5 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Prefoldin_2 PF01920.20 KPI89313.1 - 0.091 12.7 0.4 0.15 12.0 0.4 1.3 1 0 0 1 1 1 0 Prefoldin subunit TSC22 PF01166.18 KPI89313.1 - 0.11 12.9 0.2 0.21 11.9 0.2 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Phage_lysis PF03245.13 KPI89313.1 - 3.3 7.8 8.6 0.062 13.4 1.2 1.8 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein 2OG-FeII_Oxy_2 PF13532.6 KPI89314.1 - 3.7e-57 193.7 0.1 5.4e-57 193.1 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EBP PF05241.12 KPI89315.1 - 9.5e-22 77.3 1.6 1.8e-21 76.4 1.6 1.4 1 0 0 1 1 1 1 Emopamil binding protein HEPN_SAV_6107 PF18726.1 KPI89316.1 - 0.041 14.4 0.1 0.12 12.9 0.1 1.7 1 0 0 1 1 1 0 SAV_6107-like HEPN Tuberin PF03542.16 KPI89316.1 - 0.16 11.0 0.3 4.8 6.2 0.0 2.1 2 0 0 2 2 2 0 Tuberin FHA PF00498.26 KPI89317.1 - 7.6e-14 51.8 0.0 1.5e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain Met_10 PF02475.16 KPI89318.1 - 4.7e-45 153.8 0.0 1.1e-32 113.4 0.0 2.3 2 0 0 2 2 2 2 Met-10+ like-protein PrmA PF06325.13 KPI89318.1 - 0.0047 16.4 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TRM PF02005.16 KPI89318.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase RIH_assoc PF08454.11 KPI89319.1 - 3.6e-20 71.7 1.1 3.6e-20 71.7 1.1 2.3 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.31 KPI89319.1 - 8.7e-12 44.8 9.6 1.5e-11 44.0 9.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ins145_P3_rec PF08709.11 KPI89319.1 - 2.9e-11 43.0 0.0 4.4e-10 39.1 0.0 2.4 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor Pkinase PF00069.25 KPI89320.1 - 1.3e-65 221.4 0.0 1.9e-65 220.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89320.1 - 1.3e-47 162.3 0.0 1.7e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI89320.1 - 1.1e-05 24.4 0.0 1.9e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI89320.1 - 0.007 16.3 0.1 0.085 12.8 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI89320.1 - 0.018 14.3 1.0 0.098 12.0 0.0 2.5 3 1 0 3 3 3 0 Kinase-like Trp_repressor PF01371.19 KPI89320.1 - 0.054 13.6 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Trp repressor protein Nas2_N PF18265.1 KPI89321.1 - 1e-19 70.2 0.0 1.6e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 KPI89321.1 - 0.0001 22.1 0.0 0.00029 20.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KPI89321.1 - 0.015 15.6 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain THOC7 PF05615.13 KPI89321.1 - 0.039 14.2 0.5 0.039 14.2 0.5 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 DUF4239 PF14023.6 KPI89321.1 - 0.069 12.9 1.0 0.092 12.5 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) KfrA_N PF11740.8 KPI89321.1 - 5.5 7.7 16.9 19 6.0 10.2 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Hydrolase_4 PF12146.8 KPI89323.1 - 1.8e-13 50.3 1.3 2.5e-07 30.2 0.8 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KPI89323.1 - 4.2e-09 36.2 0.7 8.5e-08 31.9 0.2 2.5 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KPI89323.1 - 1.9e-08 34.3 0.3 0.00015 21.5 0.2 2.6 1 1 1 2 2 2 2 alpha/beta hydrolase fold Ank_2 PF12796.7 KPI89323.1 - 2.4e-08 34.4 0.1 2.3e-07 31.3 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI89323.1 - 9.4e-07 29.0 0.1 4.5e-05 23.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Abhydrolase_6 PF12697.7 KPI89323.1 - 1.9e-06 28.6 0.1 4.1e-06 27.6 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 KPI89323.1 - 9e-06 24.6 0.8 0.087 11.5 0.1 2.3 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) Ank_3 PF13606.6 KPI89323.1 - 9.2e-06 25.6 0.4 0.00022 21.4 0.0 3.2 4 0 0 4 4 3 1 Ankyrin repeat Ank_4 PF13637.6 KPI89323.1 - 8.7e-05 23.0 0.4 0.0013 19.3 0.1 3.1 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Peptidase_S15 PF02129.18 KPI89323.1 - 0.00025 20.7 1.1 0.02 14.5 0.1 2.5 2 1 1 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) Ank PF00023.30 KPI89323.1 - 0.00056 20.2 0.0 0.0042 17.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Say1_Mug180 PF10340.9 KPI89323.1 - 0.061 12.2 0.0 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Steryl acetyl hydrolase 3HBOH PF10605.9 KPI89323.1 - 0.067 11.4 0.1 0.66 8.1 0.0 2.3 3 0 0 3 3 3 0 3HB-oligomer hydrolase (3HBOH) MscS_TM PF12794.7 KPI89323.1 - 0.1 11.5 1.1 0.11 11.4 0.0 1.5 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Abhydro_lipase PF04083.16 KPI89323.1 - 0.11 12.1 0.1 4.5 6.9 0.0 2.5 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region DSPc PF00782.20 KPI89324.1 - 1.2e-07 31.6 0.0 1.5e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI89324.1 - 1.3e-05 24.9 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase GDPD PF03009.17 KPI89324.1 - 0.054 13.2 0.0 0.07 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family CDKN3 PF05706.12 KPI89324.1 - 0.16 11.6 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Radical_SAM_C PF16199.5 KPI89325.1 - 5.8e-20 71.1 0.1 1.2e-19 70.1 0.1 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KPI89325.1 - 1.3e-14 55.0 0.1 9.7e-14 52.1 0.0 2.4 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KPI89325.1 - 1.2e-06 28.7 0.1 2.7e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KPI89325.1 - 3.1e-06 27.1 0.1 6.5e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI89325.1 - 0.0099 16.3 0.1 0.024 15.1 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DSPc PF00782.20 KPI89326.1 - 7e-07 29.1 0.0 7.8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI89326.1 - 5.7e-05 22.8 0.0 7.2e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KPI89326.1 - 0.036 13.7 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Mito_carr PF00153.27 KPI89328.1 - 2.5e-54 181.2 4.5 3e-20 71.9 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C3G PF12381.8 KPI89328.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Tungro spherical virus-type peptidase Mito_carr PF00153.27 KPI89329.1 - 4.9e-62 205.9 2.3 3.5e-20 71.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Las1 PF04031.13 KPI89330.1 - 8.1e-28 97.5 0.0 1.3e-27 96.8 0.0 1.3 1 0 0 1 1 1 1 Las1-like SVIP PF15811.5 KPI89330.1 - 5.5 7.5 7.9 4.7 7.7 4.0 2.5 2 0 0 2 2 2 0 Small VCP/p97-interacting protein SGL PF08450.12 KPI89331.1 - 4.3e-06 26.5 0.0 3e-05 23.7 0.0 2.3 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 KPI89331.1 - 1.4e-05 24.9 0.5 0.2 11.8 0.0 4.3 4 0 0 4 4 4 3 NHL repeat PGA2 PF07543.12 KPI89332.1 - 0.11 12.5 4.6 0.18 11.8 4.6 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 KPI89332.1 - 1.4 7.1 4.6 1.7 6.8 4.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF489 PF04356.12 KPI89333.1 - 0.42 10.6 4.3 0.39 10.7 2.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Ribosomal_L17 PF01196.19 KPI89334.1 - 4.7e-12 46.6 0.0 7.1e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 eIF-1a PF01176.19 KPI89336.1 - 1.4e-10 40.8 0.4 2.2e-10 40.2 0.4 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Cupin_4 PF08007.12 KPI89337.1 - 5.6e-06 26.0 0.5 7.5e-06 25.6 0.5 1.4 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KPI89337.1 - 7.5e-06 26.4 0.0 1.9e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KPI89337.1 - 0.001 18.8 0.8 0.0074 16.0 0.1 2.1 1 1 0 2 2 2 1 Cupin-like domain GPI PF06560.11 KPI89337.1 - 0.0043 16.4 0.1 0.0079 15.5 0.1 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate isomerase (GPI) Cupin_1 PF00190.22 KPI89337.1 - 0.012 15.3 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Cupin DUF2167 PF09935.9 KPI89337.1 - 0.06 12.5 2.5 0.06 12.5 0.5 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2167) Cupin_2 PF07883.11 KPI89337.1 - 0.11 12.2 0.0 0.11 12.2 0.0 2.0 3 0 0 3 3 3 0 Cupin domain CompInhib_SCIN PF11546.8 KPI89337.1 - 0.22 11.5 0.1 0.37 10.9 0.1 1.2 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN DUF5560 PF17715.1 KPI89339.1 - 1 8.8 7.6 0.34 10.3 2.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5560) APH PF01636.23 KPI89340.1 - 9.7e-13 48.6 0.0 4.3e-12 46.5 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family MORN PF02493.20 KPI89341.1 - 3.4e-12 45.5 8.7 2.3e-07 30.3 0.5 4.6 4 0 0 4 4 4 2 MORN repeat Kelch_4 PF13418.6 KPI89344.1 - 6.6e-32 109.3 0.5 7.7e-09 35.4 0.0 6.6 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KPI89344.1 - 1.6e-24 85.7 3.1 0.0011 19.2 0.0 6.8 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KPI89344.1 - 3.2e-22 78.0 1.2 0.0046 16.9 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KPI89344.1 - 3.7e-21 74.6 4.9 0.00018 21.6 0.0 6.5 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KPI89344.1 - 3.3e-19 68.2 0.1 3e-05 23.5 0.0 6.0 6 0 0 6 6 6 4 Kelch motif DUF4110 PF13422.6 KPI89344.1 - 1.4e-18 66.8 11.8 4.9e-18 65.0 11.8 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4110) Kelch_2 PF07646.15 KPI89344.1 - 5.2e-13 48.4 4.4 0.0045 16.9 0.0 6.3 6 0 0 6 6 6 3 Kelch motif MarR_2 PF12802.7 KPI89345.1 - 0.0045 16.8 0.0 0.017 15.0 0.0 2.0 1 0 0 1 1 1 1 MarR family AAA PF00004.29 KPI89346.1 - 2.4e-44 151.0 0.0 1.1e-43 148.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KPI89346.1 - 1.6e-06 28.0 0.0 3.5e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 KPI89346.1 - 3.3e-06 27.0 0.2 2.5e-05 24.2 0.1 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_16 PF13191.6 KPI89346.1 - 4.6e-05 23.9 1.8 0.0086 16.5 0.0 3.8 3 1 0 4 4 4 1 AAA ATPase domain AAA_2 PF07724.14 KPI89346.1 - 0.0012 19.0 0.0 0.0033 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KPI89346.1 - 0.003 17.6 0.0 0.012 15.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KPI89346.1 - 0.0043 17.2 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KPI89346.1 - 0.0043 17.4 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 KPI89346.1 - 0.0066 16.5 0.0 0.05 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 KPI89346.1 - 0.009 15.8 0.2 0.15 11.9 0.1 2.8 2 0 0 2 2 2 1 AAA+ lid domain AAA_7 PF12775.7 KPI89346.1 - 0.011 15.3 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 KPI89346.1 - 0.015 14.4 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 KPI89346.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 KPI89346.1 - 0.019 14.2 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 KPI89346.1 - 0.022 14.2 0.1 0.04 13.3 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KPI89346.1 - 0.023 14.5 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 KPI89346.1 - 0.026 14.8 0.0 0.12 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KPI89346.1 - 0.03 14.8 0.0 0.056 13.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 KPI89346.1 - 0.058 12.7 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 KPI89346.1 - 0.059 13.6 0.0 0.21 11.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KPI89346.1 - 0.069 13.6 0.0 0.32 11.4 0.0 2.2 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 KPI89346.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.6 KPI89346.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KPI89346.1 - 0.11 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain DUF815 PF05673.13 KPI89346.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Rad17 PF03215.15 KPI89346.1 - 0.18 11.7 0.0 0.45 10.4 0.0 1.6 2 0 0 2 2 1 0 Rad17 P-loop domain DEAD PF00270.29 KPI89347.1 - 3.6e-16 59.4 0.0 1.8e-13 50.7 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI89347.1 - 2.1e-12 47.4 0.0 5.6e-12 46.0 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI89347.1 - 0.034 14.2 0.0 0.15 12.1 0.0 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit 2OG-FeII_Oxy_3 PF13640.6 KPI89348.1 - 6.5e-12 46.2 0.1 1.4e-11 45.1 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 KPI89348.1 - 0.00032 21.0 0.0 0.00061 20.1 0.0 1.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Pox_C4_C10 PF03336.13 KPI89348.1 - 0.0051 16.0 0.0 1.7 7.7 0.0 2.3 2 1 0 2 2 2 2 Poxvirus C4/C10 protein 2OG-FeII_Oxy PF03171.20 KPI89348.1 - 0.024 15.1 0.0 0.048 14.2 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily TPR_6 PF13174.6 KPI89348.1 - 0.1 13.3 0.2 0.47 11.2 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat 2OG-FeII_Oxy_5 PF13759.6 KPI89348.1 - 0.14 12.6 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase PrmA PF06325.13 KPI89349.1 - 2.7e-05 23.7 1.9 4e-05 23.1 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KPI89349.1 - 0.0033 17.0 0.6 0.0056 16.2 0.2 1.5 2 0 0 2 2 2 1 Methyltransferase small domain MoeA_C PF03454.15 KPI89349.1 - 0.0053 16.9 0.0 0.016 15.4 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Methyltransf_11 PF08241.12 KPI89349.1 - 0.032 14.9 0.0 0.091 13.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KPI89349.1 - 0.035 14.8 0.2 0.12 13.1 0.0 2.1 3 0 0 3 3 3 0 Methyltransferase domain ADK PF00406.22 KPI89350.1 - 1.8e-13 50.8 0.1 1.1e-06 28.9 0.0 2.4 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 KPI89350.1 - 3.8e-11 43.6 0.0 4.2e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KPI89350.1 - 2.2e-07 31.1 0.3 3e-06 27.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI89350.1 - 1.1e-06 29.2 0.0 3.7e-05 24.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI89350.1 - 1.2e-06 28.8 0.6 0.00017 21.9 0.0 2.9 1 1 1 3 3 3 2 AAA domain AAA_5 PF07728.14 KPI89350.1 - 7.3e-06 26.0 0.0 2.6e-05 24.2 0.0 1.9 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 KPI89350.1 - 1.1e-05 24.9 0.0 0.00013 21.3 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 KPI89350.1 - 3.8e-05 24.1 0.0 8.5e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 KPI89350.1 - 9.2e-05 22.7 0.4 0.00025 21.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 KPI89350.1 - 0.00022 21.2 0.0 0.0011 19.0 0.1 2.0 1 1 1 2 2 2 1 P-loop Nucleotide Kinase3 Guanylate_kin PF00625.21 KPI89350.1 - 0.00028 20.6 0.2 0.94 9.1 0.0 2.7 3 0 0 3 3 3 2 Guanylate kinase AAA PF00004.29 KPI89350.1 - 0.00031 21.2 0.0 0.00067 20.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KPI89350.1 - 0.00031 20.5 0.0 0.00047 19.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KPI89350.1 - 0.00075 19.4 0.0 0.0015 18.5 0.0 1.5 2 0 0 2 2 1 1 RsgA GTPase AAA_25 PF13481.6 KPI89350.1 - 0.001 18.7 0.2 0.0097 15.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 KPI89350.1 - 0.0016 18.1 0.2 1 9.0 0.1 2.2 1 1 1 2 2 2 2 Thymidylate kinase NACHT PF05729.12 KPI89350.1 - 0.0019 18.2 0.0 0.0047 16.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain RuvB_N PF05496.12 KPI89350.1 - 0.0025 17.6 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 KPI89350.1 - 0.0028 18.2 0.0 0.0049 17.4 0.0 1.8 1 1 0 1 1 1 1 ABC transporter SRP54 PF00448.22 KPI89350.1 - 0.0028 17.3 0.0 0.0041 16.8 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Cytidylate_kin PF02224.18 KPI89350.1 - 0.0082 15.9 0.9 0.02 14.6 0.1 1.9 2 0 0 2 2 2 1 Cytidylate kinase Mg_chelatase PF01078.21 KPI89350.1 - 0.0096 15.3 0.0 0.021 14.2 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KPI89350.1 - 0.012 16.0 0.0 0.027 14.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.23 KPI89350.1 - 0.014 15.5 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase SKI PF01202.22 KPI89350.1 - 0.02 15.0 0.6 0.15 12.2 0.1 2.2 2 0 0 2 2 2 0 Shikimate kinase NTPase_1 PF03266.15 KPI89350.1 - 0.025 14.5 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 NTPase KTI12 PF08433.10 KPI89350.1 - 0.026 14.0 0.0 0.057 12.8 0.0 1.7 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NB-ARC PF00931.22 KPI89350.1 - 0.028 13.6 0.0 0.056 12.6 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 KPI89350.1 - 0.032 14.0 0.4 0.061 13.0 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KPI89350.1 - 0.037 13.8 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KPI89350.1 - 0.051 13.3 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DAP3 PF10236.9 KPI89350.1 - 0.056 12.6 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 CoaE PF01121.20 KPI89350.1 - 0.062 13.0 1.6 0.094 12.4 0.1 2.0 3 0 0 3 3 2 0 Dephospho-CoA kinase Cytidylate_kin2 PF13189.6 KPI89350.1 - 0.066 13.3 0.6 0.35 11.0 0.1 2.2 1 1 1 2 2 2 0 Cytidylate kinase-like family TniB PF05621.11 KPI89350.1 - 0.084 12.3 0.0 0.21 11.0 0.0 1.8 1 1 0 1 1 1 0 Bacterial TniB protein Hydin_ADK PF17213.3 KPI89350.1 - 0.091 13.0 0.7 0.16 12.3 0.1 1.7 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain TsaE PF02367.17 KPI89350.1 - 0.092 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 KPI89350.1 - 0.093 12.6 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ATP_bind_1 PF03029.17 KPI89350.1 - 0.1 12.4 0.0 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein dNK PF01712.19 KPI89350.1 - 0.13 12.1 0.3 0.59 9.9 0.0 2.1 2 1 0 2 2 2 0 Deoxynucleoside kinase AAA_14 PF13173.6 KPI89350.1 - 0.17 11.9 0.0 0.54 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 KPI89350.1 - 0.17 11.1 0.0 0.19 10.9 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain Ribosomal_L27A PF00828.19 KPI89351.1 - 7.8e-07 29.8 0.0 1.3e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A ASF1_hist_chap PF04729.13 KPI89352.1 - 7.4e-28 97.4 0.0 8.9e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone DUF5597 PF18120.1 KPI89352.1 - 0.076 13.1 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5597) Catalase PF00199.19 KPI89353.1 - 3.7e-184 612.2 0.0 4.5e-184 611.9 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 KPI89353.1 - 5.6e-17 61.7 0.0 1.2e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive PCMT PF01135.19 KPI89354.1 - 2.6e-48 164.6 0.0 3.7e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KPI89354.1 - 9.7e-06 25.5 0.0 1.8e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KPI89354.1 - 0.0018 19.3 0.0 0.0035 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI89354.1 - 0.0019 18.8 0.1 0.048 14.3 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI89354.1 - 0.013 16.2 0.1 0.039 14.7 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KPI89354.1 - 0.023 14.7 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KPI89354.1 - 0.071 12.9 0.0 0.1 12.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain DUF585 PF04522.12 KPI89354.1 - 0.087 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF585) Ubie_methyltran PF01209.18 KPI89354.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family ACBP PF00887.19 KPI89355.1 - 1.8e-14 53.7 0.2 3.5e-14 52.8 0.2 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein SRI PF08236.11 KPI89356.1 - 0.0047 17.1 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain Tli4_N PF18443.1 KPI89356.1 - 0.062 13.7 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain Glyco_transf_92 PF01697.27 KPI89356.1 - 0.17 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 92 NYD-SP28_assoc PF14775.6 KPI89358.1 - 3.5e-22 78.3 3.8 3.5e-22 78.3 3.8 4.0 3 1 1 4 4 4 1 Sperm tail C-terminal domain NYD-SP28 PF14772.6 KPI89358.1 - 4.6e-17 61.9 1.5 4.6e-17 61.9 1.5 5.9 5 1 1 6 6 6 1 Sperm tail DUF1623 PF07785.11 KPI89358.1 - 0.03 14.5 0.1 0.13 12.5 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) TACC_C PF05010.14 KPI89358.1 - 3.8 7.3 53.7 0.05 13.4 15.9 4.0 2 2 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Mito_carr PF00153.27 KPI89360.1 - 9.8e-32 108.8 4.9 4e-13 49.1 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF4271 PF14093.6 KPI89361.1 - 0.0034 17.3 11.9 0.0034 17.3 11.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4271) Pombe_5TM PF09437.10 KPI89361.1 - 0.15 11.7 9.4 1.9 8.1 0.1 2.3 2 0 0 2 2 2 0 Pombe specific 5TM protein SAS-6_N PF16531.5 KPI89363.1 - 8.2e-24 84.0 0.3 1.2e-23 83.5 0.3 1.2 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal Pneumo_matrix PF03393.16 KPI89363.1 - 0.041 13.1 0.0 0.095 11.9 0.0 1.6 1 1 1 2 2 2 0 Pneumovirus matrix protein CSD PF00313.22 KPI89363.1 - 0.1 12.4 0.1 0.26 11.2 0.0 1.6 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain Metalloenzyme PF01676.18 KPI89365.1 - 3e-80 269.2 0.0 3.4e-80 269.0 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 KPI89365.1 - 2.7e-60 203.5 0.0 3.7e-60 203.0 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 KPI89365.1 - 3.6e-05 23.5 0.0 0.00012 21.8 0.0 1.8 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 KPI89365.1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 PglZ domain PGM_PMM_II PF02879.16 KPI89365.1 - 0.17 12.5 1.8 9 7.0 0.0 4.0 5 0 0 5 5 5 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II FtsJ PF01728.19 KPI89366.1 - 1.1e-26 94.0 0.0 1.8e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Cyt-b5 PF00173.28 KPI89367.1 - 6.9e-11 42.1 0.0 9.8e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UPF0242 PF06785.11 KPI89368.1 - 0.013 15.6 10.1 0.03 14.5 10.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus BCAS2 PF05700.11 KPI89368.1 - 0.16 11.7 8.8 1.1 9.0 1.3 2.1 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) FAM76 PF16046.5 KPI89368.1 - 0.16 11.3 3.9 0.071 12.5 0.6 1.8 1 1 1 2 2 2 0 FAM76 protein IZUMO PF15005.6 KPI89368.1 - 0.54 10.8 4.0 0.72 10.4 3.3 1.4 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DUF1840 PF08895.11 KPI89368.1 - 0.77 10.1 7.1 0.26 11.6 3.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF465 PF04325.13 KPI89368.1 - 0.97 9.5 5.0 2.4 8.2 0.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF465) YabA PF06156.13 KPI89368.1 - 1.1 9.9 7.9 5 7.8 4.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Solute_trans_a PF03619.16 KPI89369.1 - 3e-78 263.0 18.3 4e-78 262.6 18.3 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha AAA_22 PF13401.6 KPI89370.1 - 1.3e-06 28.7 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI89370.1 - 0.00014 22.2 0.7 0.00045 20.6 0.2 2.2 3 1 0 3 3 3 1 AAA ATPase domain RNA12 PF10443.9 KPI89370.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein Roc PF08477.13 KPI89370.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DNA_pol3_delta2 PF13177.6 KPI89372.1 - 1.9e-14 53.7 0.0 3.2e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 KPI89372.1 - 3.8e-09 37.1 0.0 1.1e-08 35.6 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 KPI89372.1 - 0.00014 22.2 0.0 0.0003 21.1 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain Sigma54_activ_2 PF14532.6 KPI89372.1 - 0.00062 19.9 0.1 0.013 15.6 0.1 2.3 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 KPI89372.1 - 0.00089 19.7 0.1 0.038 14.4 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KPI89372.1 - 0.0035 17.1 0.1 0.47 10.2 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KPI89372.1 - 0.0036 17.3 0.0 0.012 15.6 0.0 1.9 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 KPI89372.1 - 0.011 15.7 0.1 0.12 12.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KPI89372.1 - 0.015 14.7 0.0 0.72 9.2 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KPI89372.1 - 0.02 14.6 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KPI89372.1 - 0.044 13.5 0.0 7.8 6.2 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_22 PF13401.6 KPI89372.1 - 0.13 12.5 0.1 1.1 9.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain Mito_carr PF00153.27 KPI89373.1 - 8.3e-44 147.4 2.6 9.6e-16 57.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_S9_N PF02897.15 KPI89376.1 - 5.3e-99 331.8 0.8 6.8e-99 331.5 0.8 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 KPI89376.1 - 4.6e-65 219.1 0.0 7.8e-65 218.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 KPI89376.1 - 0.00015 21.5 0.0 0.00034 20.3 0.0 1.5 2 0 0 2 2 2 1 Putative esterase Hydrolase_4 PF12146.8 KPI89376.1 - 0.075 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI89376.1 - 0.095 12.3 0.0 0.87 9.2 0.1 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 KPI89376.1 - 0.1 12.2 0.0 1.1 8.8 0.0 2.5 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 KPI89376.1 - 0.11 12.3 0.1 0.26 11.1 0.1 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Haem_degrading PF03928.14 KPI89376.1 - 0.15 12.1 0.0 0.78 9.8 0.0 2.1 2 0 0 2 2 2 0 Haem-degrading OSCP PF00213.18 KPI89377.1 - 6.4e-08 32.9 0.7 2.5e-07 31.0 0.7 1.9 1 1 0 1 1 1 1 ATP synthase delta (OSCP) subunit Adaptin_N PF01602.20 KPI89378.1 - 1.4e-100 337.3 2.1 1.8e-100 337.0 2.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KPI89378.1 - 5.6e-47 159.8 0.3 5e-45 153.4 0.0 2.8 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KPI89378.1 - 3.5e-12 46.5 2.3 6.2e-05 23.3 0.0 5.6 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.22 KPI89378.1 - 1.1e-05 25.3 4.2 0.3 11.5 0.0 6.2 6 0 0 6 6 6 1 HEAT repeat RIX1 PF08167.12 KPI89378.1 - 0.00066 19.5 0.2 0.075 12.8 0.1 3.1 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 KPI89378.1 - 0.0028 17.8 0.2 1.4 9.2 0.0 3.6 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.13 KPI89378.1 - 0.027 14.4 0.2 0.3 11.0 0.0 2.6 2 0 0 2 2 2 0 UME (NUC010) domain VHS PF00790.19 KPI89378.1 - 0.06 13.2 0.0 0.21 11.4 0.0 1.9 1 0 0 1 1 1 0 VHS domain HEAT_EZ PF13513.6 KPI89378.1 - 0.2 12.2 4.8 15 6.2 0.0 4.5 4 0 0 4 4 4 0 HEAT-like repeat NIF PF03031.18 KPI89379.1 - 1.5e-33 115.7 0.0 2.2e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SET PF00856.28 KPI89380.1 - 8.4e-14 52.3 0.0 3.1e-13 50.5 0.0 1.9 1 1 0 1 1 1 1 SET domain AFG1_ATPase PF03969.16 KPI89381.1 - 1.2e-53 182.4 0.2 2.7e-51 174.6 0.0 2.9 3 0 0 3 3 3 2 AFG1-like ATPase AAA_16 PF13191.6 KPI89381.1 - 0.0028 18.1 0.5 0.018 15.5 0.3 2.4 1 1 1 2 2 2 1 AAA ATPase domain Neuropep_like PF15161.6 KPI89381.1 - 0.0034 17.0 0.2 0.0091 15.6 0.2 1.7 1 0 0 1 1 1 1 Neuropeptide-like WHH PF14414.6 KPI89381.1 - 0.012 15.4 0.0 0.052 13.4 0.0 2.1 1 1 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH E3_UFM1_ligase PF09743.9 KPI89382.1 - 7.2e-68 229.1 0.0 1.4e-66 225.0 0.1 2.2 2 0 0 2 2 2 1 E3 UFM1-protein ligase 1 Gene66 PF02053.15 KPI89382.1 - 0.034 13.8 0.2 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 Gene 66 (IR5) protein 4HBT PF03061.22 KPI89383.1 - 1.1e-06 28.9 0.0 3.4e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Thioesterase superfamily DUF4442 PF14539.6 KPI89383.1 - 0.07 13.3 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) SET PF00856.28 KPI89384.1 - 5.6e-05 23.6 0.0 0.0085 16.5 0.0 2.5 1 1 1 2 2 2 2 SET domain zf_C2HC_14 PF18574.1 KPI89384.1 - 0.028 14.2 0.1 0.092 12.6 0.1 1.9 1 0 0 1 1 1 0 C2HC Zing finger domain HTH_51 PF18558.1 KPI89384.1 - 0.05 13.5 0.1 5 7.1 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain Aa_trans PF01490.18 KPI89385.1 - 1.3e-39 136.1 33.4 1.7e-39 135.7 33.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TMEM213 PF15192.6 KPI89385.1 - 4 7.5 5.8 0.53 10.3 0.2 2.2 2 0 0 2 2 2 0 TMEM213 family TMEM65 PF10507.9 KPI89386.1 - 1.2e-37 128.2 4.2 2e-37 127.4 4.2 1.4 1 0 0 1 1 1 1 Transmembrane protein 65 EF-hand_1 PF00036.32 KPI89386.1 - 3.4e-07 29.3 0.1 0.00036 19.9 0.0 3.3 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KPI89386.1 - 4.5e-06 26.2 0.0 0.0012 18.6 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KPI89386.1 - 4.2e-05 23.9 1.6 0.016 15.6 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_14 PF17959.1 KPI89386.1 - 0.003 17.9 0.2 0.012 15.9 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 KPI89386.1 - 0.0085 15.6 0.1 0.13 11.8 0.0 2.6 3 0 0 3 3 3 1 EF hand RNA_lig_T4_1 PF09511.10 KPI89388.1 - 2e-26 93.2 0.0 4.7e-26 92.0 0.0 1.6 1 0 0 1 1 1 1 RNA ligase AAA_33 PF13671.6 KPI89388.1 - 2.6e-11 43.9 0.0 5e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI89388.1 - 3.9e-09 37.1 0.0 8.8e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KPI89388.1 - 2.8e-05 24.1 0.0 7.9e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 NACHT domain 6PF2K PF01591.18 KPI89388.1 - 0.00018 20.9 0.0 0.00032 20.1 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_17 PF13207.6 KPI89388.1 - 0.001 19.5 0.0 0.0039 17.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain CPT PF07931.12 KPI89388.1 - 0.0055 16.6 0.1 0.017 14.9 0.1 1.8 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein KTI12 PF08433.10 KPI89388.1 - 0.0067 15.9 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 KPI89388.1 - 0.013 15.8 2.4 0.023 15.1 0.2 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KPI89388.1 - 0.12 12.7 0.5 0.65 10.3 0.3 2.3 1 1 1 2 2 2 0 AAA domain AAA_25 PF13481.6 KPI89388.1 - 0.12 11.9 1.7 4.5 6.8 1.2 2.6 1 1 0 1 1 1 0 AAA domain ATP-synt_J PF04911.12 KPI89388.1 - 0.18 11.4 0.0 0.42 10.2 0.0 1.6 1 0 0 1 1 1 0 ATP synthase j chain ABC_tran PF00005.27 KPI89388.1 - 0.19 12.3 0.0 0.45 11.0 0.0 1.7 1 0 0 1 1 1 0 ABC transporter EVE PF01878.18 KPI89390.1 - 2.9e-54 183.0 0.7 3.3e-54 182.8 0.7 1.0 1 0 0 1 1 1 1 EVE domain Bromodomain PF00439.25 KPI89391.1 - 5.7e-18 64.8 0.0 1.2e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Bromodomain TA0956 PF11513.8 KPI89391.1 - 0.066 13.4 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 Nucleoporin_N PF08801.11 KPI89393.1 - 6.9e-59 199.7 0.0 1.1e-58 199.0 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like LRR_9 PF14580.6 KPI89394.1 - 0.015 14.8 0.0 0.043 13.3 0.0 1.7 2 0 0 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.6 KPI89394.1 - 0.023 14.5 0.9 0.054 13.3 0.3 2.0 2 0 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 KPI89394.1 - 0.036 14.5 0.6 0.71 10.4 0.1 2.9 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Cpn60_TCP1 PF00118.24 KPI89395.1 - 1.1e-152 509.2 6.6 1.2e-152 509.0 6.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CDC48_N PF02359.18 KPI89395.1 - 0.066 13.4 0.5 1.8 8.8 0.2 2.6 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain TctC PF03401.14 KPI89395.1 - 0.083 11.9 0.0 0.2 10.7 0.0 1.6 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor DUF374 PF04028.13 KPI89395.1 - 0.098 12.2 0.3 0.46 10.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF374) Ribosomal_L1 PF00687.21 KPI89396.1 - 5.2e-18 65.5 0.0 6.6e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family zf-C2H2_6 PF13912.6 KPI89397.1 - 0.00069 19.6 11.5 0.0016 18.4 2.4 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 KPI89397.1 - 0.0035 18.0 10.9 0.015 16.1 2.6 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KPI89397.1 - 0.0039 17.5 1.2 0.15 12.4 0.0 2.2 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KPI89397.1 - 0.027 14.8 4.1 0.18 12.1 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KPI89397.1 - 0.028 14.8 6.2 1.7 9.1 0.5 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 KPI89397.1 - 0.11 12.2 1.5 0.39 10.4 0.1 2.2 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2 PF00096.26 KPI89397.1 - 0.43 11.1 14.6 0.11 13.0 2.8 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KPI89397.1 - 8.8 6.9 11.7 1.2 9.7 0.7 3.0 3 0 0 3 3 3 0 Zinc-finger double domain Thioredoxin PF00085.20 KPI89399.1 - 2.5e-59 197.6 0.1 7.3e-33 112.6 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 KPI89399.1 - 6.3e-30 104.5 0.0 1.6e-20 73.8 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KPI89399.1 - 6.6e-15 55.5 1.2 3.1e-06 27.6 0.0 3.6 2 2 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 KPI89399.1 - 5.5e-11 42.4 0.3 0.00026 20.9 0.0 3.1 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 KPI89399.1 - 6.8e-10 39.0 0.0 0.0015 18.6 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 KPI89399.1 - 1.4e-09 38.1 0.2 0.052 13.9 0.0 4.2 3 2 1 4 4 4 3 Thioredoxin-like Thioredoxin_3 PF13192.6 KPI89399.1 - 1.2e-06 28.5 0.1 0.024 14.7 0.0 3.5 3 0 0 3 3 3 2 Thioredoxin domain Thioredoxin_9 PF14595.6 KPI89399.1 - 1.3e-06 28.2 0.0 0.064 13.0 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 KPI89399.1 - 3e-06 27.0 2.6 0.0026 17.5 0.1 3.3 3 1 1 4 4 4 2 Redoxin TraF PF13728.6 KPI89399.1 - 8.8e-06 25.7 0.0 0.049 13.4 0.0 2.6 2 0 0 2 2 2 2 F plasmid transfer operon protein OST3_OST6 PF04756.13 KPI89399.1 - 1.4e-05 24.6 0.0 0.14 11.5 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_4 PF13462.6 KPI89399.1 - 0.0039 17.4 1.4 8.7 6.5 0.0 3.6 3 1 1 4 4 4 1 Thioredoxin HyaE PF07449.11 KPI89399.1 - 0.0062 16.5 0.0 0.031 14.2 0.0 2.1 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE DSBA PF01323.20 KPI89399.1 - 0.014 15.2 0.0 10 5.8 0.0 3.2 2 1 1 3 3 3 0 DSBA-like thioredoxin domain DUF953 PF06110.11 KPI89399.1 - 0.08 12.6 0.0 34 4.1 0.0 3.3 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_5 PF13743.6 KPI89399.1 - 0.14 11.8 0.1 20 4.8 0.0 2.8 2 1 1 3 3 3 0 Thioredoxin Glutaredoxin PF00462.24 KPI89399.1 - 0.15 12.3 1.5 11 6.3 0.0 3.1 2 1 0 2 2 2 0 Glutaredoxin FA_desaturase PF00487.24 KPI89400.1 - 2.7e-32 112.6 13.2 3.8e-32 112.1 13.2 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KPI89400.1 - 7.1e-10 38.9 0.0 1.4e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IL2 PF00715.17 KPI89401.1 - 2.9 7.8 11.5 2.5 8.0 0.6 3.3 3 1 0 3 3 3 0 Interleukin 2 APG6_N PF17675.1 KPI89401.1 - 7.9 7.0 53.9 0.33 11.5 3.3 5.0 1 1 1 4 4 4 0 Apg6 coiled-coil region Methyltransf_23 PF13489.6 KPI89402.1 - 0.00086 19.2 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF3285 PF11688.8 KPI89402.1 - 0.02 14.8 0.1 0.044 13.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) Baculo_8kDa PF06096.11 KPI89402.1 - 0.052 13.6 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein DUF669 PF05037.13 KPI89402.1 - 0.11 12.7 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF669) eIF-3c_N PF05470.12 KPI89403.1 - 7.2e-15 54.3 0.5 7.2e-13 47.7 0.0 2.0 1 1 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CtIP_N PF10482.9 KPI89403.1 - 0.0099 15.9 0.7 0.0099 15.9 0.7 1.8 2 0 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain DUF4062 PF13271.6 KPI89403.1 - 0.04 14.3 0.0 0.17 12.3 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) PCI PF01399.27 KPI89403.1 - 0.14 12.7 0.0 0.49 10.9 0.0 2.0 1 0 0 1 1 1 0 PCI domain DUF309 PF03745.14 KPI89403.1 - 0.14 11.8 0.5 0.91 9.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF309) MOZ_SAS PF01853.18 KPI89405.1 - 1.8e-20 73.3 0.0 2.1e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family Peptidase_C23 PF05379.11 KPI89405.1 - 0.035 14.2 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 Carlavirus endopeptidase PSP1 PF04468.12 KPI89407.1 - 3.2e-27 94.6 0.1 5.7e-27 93.8 0.1 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region HAS-barrel PF09378.10 KPI89407.1 - 0.081 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 HAS barrel domain Ribonuc_red_sm PF00268.21 KPI89408.1 - 1.2e-33 116.8 0.0 1.5e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain MORN PF02493.20 KPI89409.1 - 0.00053 19.7 11.8 0.24 11.3 1.4 3.6 3 0 0 3 3 3 3 MORN repeat WD40 PF00400.32 KPI89411.1 - 1.2e-10 41.8 18.6 0.032 15.1 0.4 7.1 7 1 0 7 7 7 5 WD domain, G-beta repeat GTP_EFTU PF00009.27 KPI89412.1 - 5.6e-33 114.1 1.9 1.8e-31 109.2 1.9 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KPI89412.1 - 2.9e-11 43.4 0.1 6.3e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI89412.1 - 9.9e-06 25.2 0.0 2.7e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 KPI89412.1 - 2.2e-05 24.0 0.0 5.8e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 KPI89412.1 - 0.001 18.8 0.1 0.0029 17.3 0.1 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation IF-2 PF11987.8 KPI89412.1 - 0.0034 17.5 0.0 0.016 15.4 0.0 2.2 2 0 0 2 2 2 1 Translation-initiation factor 2 MeaB PF03308.16 KPI89412.1 - 0.0057 15.7 0.4 0.014 14.4 0.4 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 KPI89412.1 - 0.0096 16.1 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 KPI89412.1 - 0.011 15.8 2.5 0.65 10.0 0.0 2.7 2 1 1 3 3 3 0 Dynamin family DUF4211 PF13926.6 KPI89413.1 - 0.07 13.2 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4211) HRDC PF00570.23 KPI89413.1 - 0.2 11.7 0.7 2.1 8.4 0.0 2.6 2 0 0 2 2 2 0 HRDC domain WD40 PF00400.32 KPI89415.1 - 9.1e-07 29.5 2.3 0.018 15.9 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89415.1 - 0.047 14.0 0.0 11 6.4 0.0 3.4 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain ChaC PF04752.12 KPI89416.1 - 1.3e-43 149.1 0.1 7.8e-43 146.6 0.1 1.9 1 1 0 1 1 1 1 ChaC-like protein Ada_Zn_binding PF02805.16 KPI89416.1 - 0.021 14.8 0.8 0.42 10.7 1.1 2.2 2 0 0 2 2 2 0 Metal binding domain of Ada Pkinase PF00069.25 KPI89418.1 - 3.4e-24 85.6 0.0 2.5e-19 69.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89418.1 - 4.5e-11 42.5 0.0 9.5e-11 41.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89418.1 - 0.0084 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RNA_pol_Rpc34 PF05158.12 KPI89418.1 - 0.12 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit IQ PF00612.27 KPI89418.1 - 2 8.5 3.8 4.7 7.3 3.8 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif Pkinase PF00069.25 KPI89420.1 - 4.2e-11 42.7 0.4 0.0001 21.8 0.1 3.6 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89420.1 - 0.0094 15.3 0.0 4.1 6.6 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase Adap_comp_sub PF00928.21 KPI89421.1 - 2.2e-82 276.4 0.0 2.8e-82 276.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KPI89421.1 - 0.023 14.6 1.5 0.038 13.9 1.5 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Lactamase_B_2 PF12706.7 KPI89422.1 - 1.4e-08 34.5 0.1 1.5e-05 24.6 0.1 2.4 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KPI89422.1 - 0.0052 16.8 0.1 0.0093 16.0 0.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KPI89423.1 - 7.4e-12 45.2 0.0 9.5e-09 35.0 0.0 2.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KPI89423.1 - 0.00037 20.6 0.8 0.00074 19.6 0.8 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily AAA_6 PF12774.7 KPI89424.1 - 1.2e-130 435.3 0.2 1.8e-128 428.1 0.0 3.6 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI89424.1 - 1.3e-83 281.3 0.1 1.3e-83 281.3 0.1 2.2 2 0 0 2 2 1 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KPI89424.1 - 1e-63 214.4 0.0 2.3e-62 210.0 0.0 2.6 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 KPI89424.1 - 1.2e-59 201.8 0.3 4.2e-38 131.2 0.0 2.9 3 0 0 3 3 2 2 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KPI89424.1 - 6.8e-46 156.1 0.1 5.3e-38 130.3 0.0 4.7 5 0 0 5 5 4 2 P-loop containing dynein motor region MT PF12777.7 KPI89424.1 - 3.1e-36 125.1 1.9 4.9e-36 124.4 1.9 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KPI89424.1 - 1.5e-28 99.5 0.0 3.6e-05 23.8 0.0 6.9 5 1 0 5 5 5 5 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 KPI89424.1 - 1.4e-22 80.0 0.0 1.4e-21 76.7 0.0 3.0 3 0 0 3 3 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 KPI89424.1 - 3.5e-22 79.0 0.0 6.9e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_C PF18199.1 KPI89424.1 - 6.7e-20 71.5 0.0 6.7e-20 71.5 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA PF00004.29 KPI89424.1 - 1.7e-19 70.6 0.0 8.2e-06 26.3 0.0 5.2 4 0 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KPI89424.1 - 1.4e-13 51.3 9.8 1.5e-05 25.3 0.0 6.8 7 0 0 7 7 5 3 AAA domain AAA_16 PF13191.6 KPI89424.1 - 6.2e-11 43.0 9.8 0.062 13.7 0.0 7.0 6 0 0 6 6 4 4 AAA ATPase domain AAA_33 PF13671.6 KPI89424.1 - 1e-08 35.4 0.1 0.097 12.8 0.0 5.3 4 0 0 4 4 4 2 AAA domain AAA_24 PF13479.6 KPI89424.1 - 2e-07 31.0 0.2 2.2 7.9 0.0 4.6 4 0 0 4 4 4 3 AAA domain AAA_18 PF13238.6 KPI89424.1 - 1.5e-06 28.8 0.0 2.6 8.6 0.0 5.4 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 KPI89424.1 - 1.6e-06 27.4 0.0 0.093 11.8 0.0 4.1 4 0 0 4 4 4 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 KPI89424.1 - 3.4e-06 26.9 0.6 0.18 11.5 0.0 4.5 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_30 PF13604.6 KPI89424.1 - 3.5e-06 26.9 3.5 0.77 9.4 0.1 4.6 4 0 0 4 4 4 2 AAA domain AAA_14 PF13173.6 KPI89424.1 - 1.7e-05 24.9 0.0 0.99 9.4 0.0 4.8 4 0 0 4 4 4 1 AAA domain FtsK_SpoIIIE PF01580.18 KPI89424.1 - 3.5e-05 23.3 0.5 0.49 9.7 0.0 3.8 4 0 0 4 4 3 2 FtsK/SpoIIIE family RNA_helicase PF00910.22 KPI89424.1 - 6.4e-05 23.3 0.3 3 8.3 0.0 4.7 4 0 0 4 4 4 1 RNA helicase Mg_chelatase PF01078.21 KPI89424.1 - 0.00012 21.6 4.9 0.35 10.2 0.0 4.0 4 0 0 4 4 3 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KPI89424.1 - 0.00015 21.6 0.0 0.42 10.3 0.0 3.4 3 0 0 3 3 3 1 Sigma-54 interaction domain Dynein_AAA_lid PF17852.1 KPI89424.1 - 0.00015 21.8 0.1 0.00057 20.0 0.1 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_25 PF13481.6 KPI89424.1 - 0.00032 20.3 1.8 0.71 9.4 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_lid_1 PF17857.1 KPI89424.1 - 0.00037 20.7 0.0 0.005 17.0 0.0 2.7 2 0 0 2 2 2 1 AAA+ lid domain RsgA_GTPase PF03193.16 KPI89424.1 - 0.00053 19.9 0.1 10 6.0 0.0 3.9 3 0 0 3 3 3 0 RsgA GTPase AAA_29 PF13555.6 KPI89424.1 - 0.0013 18.4 0.6 2.7 7.8 0.0 3.8 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_28 PF13521.6 KPI89424.1 - 0.0016 18.7 0.1 51 4.1 0.0 5.3 4 0 0 4 4 4 0 AAA domain RuvB_N PF05496.12 KPI89424.1 - 0.0016 18.2 0.3 1.3 8.8 0.0 3.7 4 0 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 KPI89424.1 - 0.0022 18.3 12.3 1.9 8.8 0.1 6.0 6 0 0 6 6 5 2 AAA domain Rad17 PF03215.15 KPI89424.1 - 0.0091 15.9 0.0 6.9 6.5 0.0 4.2 4 0 0 4 4 4 0 Rad17 P-loop domain ABC_tran PF00005.27 KPI89424.1 - 0.016 15.8 8.9 2.7 8.5 0.0 4.9 5 0 0 5 5 3 0 ABC transporter PhoH PF02562.16 KPI89424.1 - 0.02 14.4 3.4 0.51 9.8 0.0 3.7 4 0 0 4 4 4 0 PhoH-like protein SRP54 PF00448.22 KPI89424.1 - 0.063 12.9 3.7 2.9 7.5 0.1 4.0 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain POT1PC PF16686.5 KPI89424.1 - 0.11 12.3 0.1 0.42 10.5 0.0 1.9 2 0 0 2 2 1 0 ssDNA-binding domain of telomere protection protein DASH_Dam1 PF08653.10 KPI89424.1 - 0.14 12.0 0.4 5.4 6.9 0.0 3.7 3 0 0 3 3 3 0 DASH complex subunit Dam1 DegQ PF08181.11 KPI89424.1 - 0.17 12.0 1.4 0.5 10.5 1.4 1.8 1 0 0 1 1 1 0 DegQ (SacQ) family Roc PF08477.13 KPI89424.1 - 0.3 11.3 1.4 30 4.8 0.0 3.4 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Caps_synth_GfcC PF06251.11 KPI89424.1 - 2.3 7.8 5.2 13 5.3 5.5 2.2 2 0 0 2 2 1 0 Capsule biosynthesis GfcC Sec8_exocyst PF04048.14 KPI89424.1 - 6.5 6.6 8.6 70 3.3 2.1 4.7 5 0 0 5 5 4 0 Sec8 exocyst complex component specific domain zf-C3HC4_3 PF13920.6 KPI89425.1 - 7.3e-08 32.2 14.3 1.3e-07 31.4 14.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI89425.1 - 0.99 9.4 13.9 1.9 8.5 13.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KPI89425.1 - 4.4 7.2 13.5 8.8 6.3 13.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CRAL_TRIO PF00650.20 KPI89426.1 - 6.1e-13 48.8 0.0 1.1e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain HCMV_UL124 PF17609.2 KPI89427.1 - 0.11 12.7 1.0 0.17 12.0 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function FUSC PF04632.12 KPI89428.1 - 4 5.9 27.3 0.11 11.0 3.1 3.1 2 1 0 2 2 2 0 Fusaric acid resistance protein family LSM PF01423.22 KPI89429.1 - 4e-12 45.6 0.1 5.1e-12 45.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain SP2 PF03014.14 KPI89429.1 - 0.016 13.6 0.0 0.017 13.5 0.0 1.1 1 0 0 1 1 1 0 Structural protein 2 SM-ATX PF14438.6 KPI89429.1 - 0.057 13.6 0.1 0.071 13.3 0.1 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain Gemin7 PF11095.8 KPI89429.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) MFS_1 PF07690.16 KPI89430.1 - 7.6e-24 84.3 15.7 7.6e-24 84.3 15.7 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KPI89430.1 - 2.2e-18 66.4 0.4 2.2e-18 66.4 0.4 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 KPI89430.1 - 2.4e-18 65.7 6.2 4.6e-12 45.0 0.1 3.5 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 KPI89430.1 - 7.4e-11 41.9 8.2 1.3e-09 37.9 0.1 2.4 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB LPD23 PF18838.1 KPI89431.1 - 0.85 9.4 5.9 1.8 8.4 1.5 3.4 2 0 0 2 2 2 0 Large polyvalent protein associated domain 23 Kelch_5 PF13854.6 KPI89432.1 - 2.1e-20 72.3 9.5 2e-05 24.4 0.6 7.7 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.6 KPI89432.1 - 2.7e-15 56.1 16.1 2.8e-05 24.0 0.0 7.2 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KPI89432.1 - 2.2e-13 50.0 6.7 0.036 14.4 0.2 6.8 7 0 0 7 7 7 3 Kelch motif Kelch_3 PF13415.6 KPI89432.1 - 4.5e-12 45.9 23.1 0.00018 21.7 0.1 8.5 9 0 0 9 9 9 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KPI89432.1 - 9.3e-11 41.1 17.0 0.0011 18.5 0.8 7.0 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.15 KPI89432.1 - 5.8e-06 26.1 9.6 0.0042 17.0 0.3 5.6 6 0 0 6 6 6 2 Kelch motif BTB PF00651.31 KPI89432.1 - 0.0013 18.9 0.2 0.068 13.4 0.0 3.1 3 0 0 3 3 3 1 BTB/POZ domain UAA PF08449.11 KPI89434.1 - 2.8e-31 108.8 14.1 2.8e-30 105.6 14.1 2.4 1 1 0 1 1 1 1 UAA transporter family OATP PF03137.20 KPI89434.1 - 0.01 14.2 3.7 0.056 11.7 0.0 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family WD40 PF00400.32 KPI89437.1 - 1.3e-09 38.5 4.0 0.0026 18.6 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat NPR2 PF06218.11 KPI89438.1 - 0.0078 15.0 0.0 1 8.1 0.0 2.3 2 0 0 2 2 2 2 Nitrogen permease regulator 2 Kinesin PF00225.23 KPI89439.1 - 3e-89 299.2 0.0 1.9e-88 296.6 0.0 2.3 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KPI89439.1 - 6.2e-15 55.4 0.1 8.1e-08 32.3 0.1 4.0 2 1 1 3 3 3 2 Microtubule binding bZIP_2 PF07716.15 KPI89439.1 - 0.0099 15.9 1.5 0.0099 15.9 1.5 9.0 10 0 0 10 10 10 2 Basic region leucine zipper GPW_gp25 PF04965.14 KPI89439.1 - 0.13 12.0 4.3 0.14 12.0 0.4 2.9 2 0 0 2 2 2 0 Gene 25-like lysozyme Pkinase PF00069.25 KPI89440.1 - 6.1e-63 212.6 0.0 7.2e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89440.1 - 4.5e-43 147.4 0.0 5.7e-43 147.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89440.1 - 1e-09 38.2 0.0 2.4e-09 37.0 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KPI89440.1 - 0.0002 20.3 0.0 0.00032 19.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KPI89440.1 - 0.028 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4705 PF15788.5 KPI89443.1 - 0.0053 17.0 0.0 0.0087 16.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4705) DUF3306 PF11748.8 KPI89444.1 - 2.9 8.8 11.8 0.47 11.3 7.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) TPP_enzyme_N PF02776.18 KPI89445.1 - 9e-13 48.2 0.3 2.4e-12 46.8 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 KPI89445.1 - 1.2e-11 44.7 2.6 5.6e-11 42.4 0.5 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Kelch_3 PF13415.6 KPI89446.1 - 6.2e-15 55.1 8.4 1.3e-05 25.3 0.0 4.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KPI89446.1 - 2e-14 53.3 0.3 2e-06 27.7 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KPI89446.1 - 7e-14 51.4 0.9 1.4e-06 28.1 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KPI89446.1 - 1.3e-11 44.3 2.7 1e-05 25.6 0.0 4.4 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 KPI89446.1 - 4.8e-11 42.2 0.9 3e-05 23.8 0.0 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 KPI89446.1 - 1.8e-08 33.8 5.8 0.00017 21.1 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Helicase_C_2 PF13307.6 KPI89447.1 - 1.9e-43 148.6 0.0 5.6e-43 147.1 0.0 1.7 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 KPI89447.1 - 8.7e-36 123.2 0.0 1.6e-35 122.3 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 KPI89447.1 - 4.9e-05 23.4 0.0 0.029 14.4 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 KPI89447.1 - 0.00041 20.2 0.0 0.35 10.6 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Transglut_core3 PF13471.6 KPI89447.1 - 2.2 8.2 7.3 0.21 11.5 0.4 3.0 3 0 0 3 3 3 0 Transglutaminase-like superfamily KAR9 PF08580.10 KPI89447.1 - 7.5 5.0 7.3 11 4.4 7.3 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 TruD PF01142.18 KPI89449.1 - 1.1e-30 106.8 0.0 5.1e-27 94.8 0.0 3.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) DUF3342 PF11822.8 KPI89450.1 - 4.2e-28 97.4 0.0 6.7e-28 96.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Pkinase_Tyr PF07714.17 KPI89453.1 - 9.1e-08 31.7 0.0 5.3e-07 29.2 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 KPI89453.1 - 0.008 15.6 0.0 0.35 10.2 0.0 2.5 1 1 1 2 2 2 1 Protein kinase domain U79_P34 PF03064.16 KPI89453.1 - 0.12 11.7 1.6 0.3 10.4 1.6 1.6 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Pkinase PF00069.25 KPI89455.1 - 6.4e-65 219.1 0.0 9.1e-65 218.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89455.1 - 3.5e-37 128.1 0.0 5.2e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Lipocalin_5 PF13924.6 KPI89455.1 - 5.4e-29 100.8 0.0 9.6e-29 100.0 0.0 1.4 1 0 0 1 1 1 1 Lipocalin-like domain PX PF00787.24 KPI89455.1 - 1.9e-12 47.2 0.1 3.9e-12 46.1 0.1 1.4 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.6 KPI89455.1 - 1.6e-05 24.4 0.0 3.6e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 Kinase-like FYVE PF01363.21 KPI89455.1 - 0.00015 21.8 1.4 0.00015 21.8 1.4 2.0 2 0 0 2 2 1 1 FYVE zinc finger APH PF01636.23 KPI89455.1 - 0.0075 16.2 3.0 0.013 15.4 0.3 2.7 3 1 1 4 4 4 1 Phosphotransferase enzyme family FTA2 PF13095.6 KPI89455.1 - 0.015 14.9 0.0 3.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KPI89455.1 - 0.029 13.1 0.0 0.05 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase C1_2 PF03107.16 KPI89455.1 - 0.1 13.0 3.1 0.28 11.5 3.1 1.8 1 0 0 1 1 1 0 C1 domain Kdo PF06293.14 KPI89455.1 - 0.13 11.6 0.1 0.33 10.3 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sulfate_transp PF00916.20 KPI89456.1 - 5.2e-50 170.3 18.1 9.4e-50 169.4 18.1 1.4 1 0 0 1 1 1 1 Sulfate permease family His_Phos_2 PF00328.22 KPI89456.1 - 3e-13 49.9 0.0 3.1e-12 46.6 0.0 2.1 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) STAS PF01740.21 KPI89456.1 - 3.6e-07 29.8 0.0 6.9e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KPI89456.1 - 9.1 6.7 15.4 0.015 15.7 3.4 2.5 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily zf-HIT PF04438.16 KPI89457.1 - 0.0095 15.8 4.5 0.019 14.8 4.5 1.5 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.24 KPI89457.1 - 0.26 11.5 3.8 0.67 10.2 3.8 1.7 1 0 0 1 1 1 0 B-box zinc finger PRKG1_interact PF15898.5 KPI89458.1 - 9.5 7.2 9.0 1.1 10.2 2.0 3.0 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain RPN2_C PF18004.1 KPI89460.1 - 3.1e-28 98.7 0.0 4.7e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 KPI89460.1 - 7.4e-16 57.7 8.7 0.034 14.6 0.0 7.9 7 0 0 7 7 7 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KPI89460.1 - 4.1e-15 56.0 1.4 8.1e-11 42.2 0.0 4.3 4 0 0 4 4 4 2 HEAT repeats TPR_4 PF07721.14 KPI89460.1 - 0.03 14.9 5.6 4.5 8.2 0.1 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89460.1 - 0.12 13.3 0.1 14 6.8 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Cnd1 PF12717.7 KPI89460.1 - 0.19 11.7 1.6 21 5.1 0.1 3.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Methyltr_RsmB-F PF01189.17 KPI89461.1 - 6.8e-27 94.4 0.1 1.3e-14 54.3 0.1 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_30 PF05430.11 KPI89462.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Pkinase PF00069.25 KPI89463.1 - 5.8e-13 48.8 0.0 8.8e-12 44.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 KPI89463.1 - 0.0016 18.4 0.0 0.0052 16.7 0.0 1.9 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 KPI89463.1 - 0.005 16.2 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ArfGap PF01412.18 KPI89464.1 - 1.5e-37 128.3 0.0 2.5e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Topoisom_bac PF01131.20 KPI89465.1 - 3.2e-109 365.7 0.0 3.9e-109 365.4 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KPI89465.1 - 2.2e-17 63.1 0.0 4e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Toprim domain AAA PF00004.29 KPI89466.1 - 4.2e-31 108.1 0.0 6.5e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI89466.1 - 4.1e-07 30.5 0.0 1.1e-06 29.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KPI89466.1 - 1.6e-06 28.4 0.0 4.4e-06 27.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KPI89466.1 - 6e-06 26.1 0.0 3.5e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KPI89466.1 - 0.00019 22.0 0.0 0.00035 21.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI89466.1 - 0.00022 21.4 0.0 0.00043 20.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KPI89466.1 - 0.0018 18.3 0.0 0.0035 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 KPI89466.1 - 0.0019 18.4 0.0 0.0049 17.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KPI89466.1 - 0.0022 18.4 0.0 0.0047 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 KPI89466.1 - 0.0027 17.3 0.2 0.27 10.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KPI89466.1 - 0.0037 16.8 0.0 0.018 14.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region Cytidylate_kin PF02224.18 KPI89466.1 - 0.0057 16.4 0.1 0.011 15.5 0.1 1.6 1 1 0 1 1 1 1 Cytidylate kinase TsaE PF02367.17 KPI89466.1 - 0.0094 16.0 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 KPI89466.1 - 0.018 14.8 0.0 0.055 13.2 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_11 PF13086.6 KPI89466.1 - 0.019 14.8 0.0 0.037 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KPI89466.1 - 0.02 14.8 0.0 0.051 13.5 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 KPI89466.1 - 0.034 13.9 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KPI89466.1 - 0.037 13.2 0.1 0.41 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_17 PF13207.6 KPI89466.1 - 0.038 14.4 0.0 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KPI89466.1 - 0.04 13.6 0.0 0.21 11.3 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_13 PF13166.6 KPI89466.1 - 0.051 12.2 0.0 0.073 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KPI89466.1 - 0.087 12.2 0.0 0.23 10.8 0.0 1.7 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 KPI89466.1 - 0.11 12.4 0.0 0.46 10.4 0.0 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 KPI89466.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Parvo_NS1 PF01057.17 KPI89466.1 - 0.21 10.6 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PduV-EutP PF10662.9 KPI89466.1 - 0.22 11.3 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TIP49 PF06068.13 KPI89466.1 - 0.23 10.6 0.0 0.35 10.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain DUF932 PF06067.11 KPI89468.1 - 0.081 12.7 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF932) SYCP2_ARLD PF18581.1 KPI89468.1 - 0.22 11.5 0.0 0.3 11.1 0.0 1.2 1 0 0 1 1 1 0 Synaptonemal complex 2 armadillo-repeat-like domain Rep_fac-A_C PF08646.10 KPI89469.1 - 2.5e-40 137.6 0.4 6.1e-39 133.1 0.1 2.7 3 0 0 3 3 3 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KPI89469.1 - 3.7e-23 81.3 2.1 6e-21 74.2 0.7 3.0 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 KPI89469.1 - 3.8e-14 52.4 0.7 1.3e-08 34.7 0.0 3.3 3 1 0 3 3 3 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 KPI89469.1 - 6e-07 29.4 0.0 3.5e-05 23.6 0.0 2.7 2 1 0 2 2 2 1 Cell division control protein 24, OB domain 3 tRNA_anti_2 PF13742.6 KPI89469.1 - 0.026 14.7 0.0 0.18 12.0 0.0 2.2 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain DUF5088 PF17008.5 KPI89469.1 - 0.039 13.7 0.1 0.057 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5088) zinc-ribbons_6 PF07191.12 KPI89469.1 - 0.091 12.8 0.8 0.18 11.8 0.8 1.4 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.7 KPI89469.1 - 0.11 12.6 1.1 0.19 11.8 1.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf_UBZ PF18439.1 KPI89469.1 - 0.27 10.9 1.6 13 5.5 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger OrfB_Zn_ribbon PF07282.11 KPI89469.1 - 0.31 11.0 2.1 0.63 10.0 2.1 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain SNF2_N PF00176.23 KPI89470.1 - 2.1e-59 201.0 0.0 3.2e-59 200.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI89470.1 - 2.5e-11 43.9 0.0 1.3e-10 41.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 KPI89470.1 - 2.3e-09 36.9 9.4 2.3e-09 36.9 9.4 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KPI89470.1 - 3.2e-09 36.5 9.3 3.2e-09 36.5 9.3 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI89470.1 - 2.5e-08 34.1 9.8 2.5e-08 34.1 9.8 3.2 3 0 0 3 3 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KPI89470.1 - 2.4e-07 30.6 6.3 7.8e-07 29.0 6.3 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KPI89470.1 - 2.7e-07 30.3 10.4 2.7e-07 30.3 10.4 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI89470.1 - 4.5e-07 29.6 8.0 4.5e-07 29.6 8.0 3.0 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KPI89470.1 - 5.1e-06 26.4 8.3 5.1e-06 26.4 8.3 3.4 3 0 0 3 3 3 1 zinc-RING finger domain ResIII PF04851.15 KPI89470.1 - 7.8e-06 26.0 0.0 1.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KPI89470.1 - 0.002 18.0 0.0 0.073 12.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-rbx1 PF12678.7 KPI89470.1 - 0.003 17.8 5.6 0.003 17.8 5.6 2.6 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KPI89470.1 - 0.0031 17.6 9.4 0.0031 17.6 9.4 2.4 3 0 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-RanBP PF00641.18 KPI89470.1 - 0.014 14.7 0.7 0.014 14.7 0.7 3.5 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others zf-RING_6 PF14835.6 KPI89470.1 - 0.022 14.6 2.0 0.078 12.9 2.0 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 KPI89470.1 - 0.035 13.9 6.1 0.093 12.5 6.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.7 KPI89470.1 - 2.1 8.4 24.8 0.26 11.4 0.6 3.9 2 2 1 3 3 3 0 Double zinc ribbon Aldolase_II PF00596.21 KPI89471.1 - 7.3e-45 153.2 0.0 8.3e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Adeno_VII PF03228.14 KPI89471.1 - 0.1 13.2 0.0 0.2 12.3 0.0 1.4 1 0 0 1 1 1 0 Adenoviral core protein VII Kinesin PF00225.23 KPI89472.1 - 3.5e-91 305.6 0.2 6.8e-91 304.6 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI89472.1 - 1.7e-38 131.9 0.0 1.5e-31 109.4 0.0 2.5 2 0 0 2 2 2 2 Microtubule binding ZapB PF06005.12 KPI89472.1 - 1.2 9.6 16.7 1.2 9.6 1.8 3.3 2 1 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 KPI89472.1 - 1.9 8.6 9.6 0.93 9.6 0.4 3.4 3 0 0 3 3 3 0 bZIP transcription factor FAM53 PF15242.6 KPI89472.1 - 7.9 6.2 18.1 1.4 8.7 12.8 2.3 2 0 0 2 2 2 0 Family of FAM53 DUF4586 PF15239.6 KPI89473.1 - 1.5e-33 117.3 0.4 1.9e-33 117.0 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Methyltransf_16 PF10294.9 KPI89474.1 - 1.1e-14 54.6 0.1 3.3e-11 43.2 0.1 3.2 2 1 0 2 2 2 2 Lysine methyltransferase Methyltransf_12 PF08242.12 KPI89474.1 - 0.031 15.0 0.0 0.062 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RIBIOP_C PF04950.12 KPI89475.1 - 3.1e-79 266.5 0.0 3.1e-79 266.5 0.0 1.8 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KPI89475.1 - 1.9e-22 79.1 0.0 1.2e-21 76.6 0.0 2.4 3 0 0 3 3 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 KPI89475.1 - 3.8e-05 24.0 0.0 0.00031 21.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KPI89475.1 - 0.00033 20.4 0.2 0.0013 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KPI89475.1 - 0.0017 18.8 0.0 0.011 16.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI89475.1 - 0.0029 18.0 2.3 0.0032 17.9 0.0 2.2 3 0 0 3 3 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KPI89475.1 - 0.0035 17.4 0.1 0.013 15.5 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KPI89475.1 - 0.0039 17.7 0.8 0.05 14.1 0.0 2.9 3 0 0 3 3 3 1 ABC transporter GTP_EFTU PF00009.27 KPI89475.1 - 0.0055 16.3 0.0 0.18 11.3 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_5 PF07728.14 KPI89475.1 - 0.0059 16.6 0.2 0.1 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KPI89475.1 - 0.016 15.4 0.7 0.048 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KPI89475.1 - 0.018 15.4 0.0 0.049 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KPI89475.1 - 0.019 14.9 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 NTPase ATP_bind_1 PF03029.17 KPI89475.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 KPI89475.1 - 0.04 13.8 0.0 0.098 12.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 KPI89475.1 - 0.04 14.4 0.7 33 4.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 KPI89475.1 - 0.046 12.9 0.0 0.087 12.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 KPI89475.1 - 0.062 13.8 0.4 0.27 11.8 0.0 2.4 2 0 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 KPI89475.1 - 0.064 13.2 0.1 0.39 10.6 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 KPI89475.1 - 0.1 12.3 0.2 0.32 10.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain cobW PF02492.19 KPI89475.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RuvB_N PF05496.12 KPI89475.1 - 0.15 11.8 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 KPI89475.1 - 0.17 11.4 0.1 0.75 9.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 KPI89475.1 - 0.63 9.8 0.0 0.63 9.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 KPI89475.1 - 1.4 9.4 0.0 1.4 9.4 0.0 3.4 4 0 0 4 4 3 0 AAA domain DHHC PF01529.20 KPI89476.1 - 2.2e-22 79.6 10.9 2.2e-22 79.6 10.9 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Zn_peptidase PF04228.13 KPI89476.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase E1-E2_ATPase PF00122.20 KPI89476.1 - 1.7 8.1 6.4 4.2 6.8 5.8 1.9 2 0 0 2 2 2 0 E1-E2 ATPase zf-ribbon_3 PF13248.6 KPI89476.1 - 6.3 6.3 9.0 3.5 7.2 0.0 3.1 3 0 0 3 3 3 0 zinc-ribbon domain DnaJ PF00226.31 KPI89477.1 - 2.3e-06 27.6 0.0 5.5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain BCIP PF13862.6 KPI89478.1 - 2.9e-33 115.4 0.0 6e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Hamartin PF04388.12 KPI89478.1 - 5 5.7 6.3 7.7 5.0 6.3 1.3 1 0 0 1 1 1 0 Hamartin protein dsDNA_bind PF01984.20 KPI89479.1 - 1.2e-20 73.8 10.3 1.5e-20 73.6 10.3 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain HTH_40 PF14493.6 KPI89479.1 - 0.07 13.6 0.8 0.23 12.0 0.1 1.9 1 1 1 2 2 2 0 Helix-turn-helix domain UPF0154 PF03672.13 KPI89479.1 - 0.39 10.8 8.8 1.5 8.9 0.1 3.1 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0154) YlqD PF11068.8 KPI89479.1 - 2.5 8.5 12.3 2.5 8.5 11.7 1.3 1 1 0 1 1 1 0 YlqD protein DUF2870 PF11069.8 KPI89479.1 - 5.5 7.5 9.1 3.8 8.0 5.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2870) E1-E2_ATPase PF00122.20 KPI89480.1 - 1e-46 158.8 3.6 1.1e-46 158.6 1.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KPI89480.1 - 4.3e-34 118.6 0.6 9.2e-34 117.6 0.6 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 KPI89480.1 - 6.7e-27 93.7 9.3 5.3e-10 39.6 0.3 3.5 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 KPI89480.1 - 1.5e-05 24.9 0.0 7.1e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KPI89480.1 - 0.02 15.3 0.0 0.053 13.9 0.0 1.8 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ProQ_C PF17516.2 KPI89480.1 - 0.19 11.2 0.8 12 5.4 0.1 3.5 3 0 0 3 3 3 0 ProQ C-terminal domain Pkinase PF00069.25 KPI89482.1 - 3.4e-45 154.5 0.0 3.9e-34 118.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89482.1 - 2.3e-26 92.6 0.2 1.6e-17 63.7 0.1 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI89482.1 - 0.0042 16.4 0.0 0.013 14.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like HEAT PF02985.22 KPI89484.1 - 0.16 12.3 0.3 39 4.9 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat Nup84_Nup100 PF04121.13 KPI89485.1 - 2.8e-09 35.7 0.1 0.00023 19.4 0.1 2.4 2 0 0 2 2 2 2 Nuclear pore protein 84 / 107 Arm PF00514.23 KPI89487.1 - 0.00034 20.5 5.4 1 9.5 0.0 5.1 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 KPI89487.1 - 0.022 14.7 1.4 0.7 9.8 0.6 2.7 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central RICTOR_V PF14668.6 KPI89487.1 - 0.041 14.1 1.6 0.84 9.9 0.1 3.5 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 Peptidase_C2 PF00648.21 KPI89488.1 - 5.3e-32 111.0 0.0 9e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease MIT PF04212.18 KPI89488.1 - 2.5e-07 30.7 0.8 6.2e-07 29.4 0.6 1.7 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Calpain_III PF01067.22 KPI89488.1 - 3.4e-07 30.6 0.0 0.00019 21.7 0.0 3.3 3 0 0 3 3 3 1 Calpain large subunit, domain III TPR_2 PF07719.17 KPI89488.1 - 0.028 14.5 0.0 0.9 9.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI89488.1 - 0.038 13.8 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89488.1 - 0.12 12.4 0.1 10 6.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ATG16 PF08614.11 KPI89488.1 - 0.13 12.4 0.2 0.25 11.6 0.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Wzy_C_2 PF11846.8 KPI89488.1 - 0.2 11.6 1.2 11 5.9 0.1 2.4 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 KPI89488.1 - 0.23 11.8 0.5 9.5 6.6 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat PEN-2 PF10251.9 KPI89489.1 - 2.1e-07 31.2 6.8 6.1e-07 29.8 6.8 1.8 1 1 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase FA_desaturase PF00487.24 KPI89489.1 - 0.0029 17.5 4.1 0.0036 17.2 4.1 1.1 1 0 0 1 1 1 1 Fatty acid desaturase SR-25 PF10500.9 KPI89490.1 - 9 5.8 21.7 0.8 9.3 3.4 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 KPI89491.1 - 4.2e-60 203.3 0.0 5.6e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89491.1 - 5.5e-38 130.7 0.1 7.4e-38 130.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KPI89491.1 - 1.6e-09 38.2 0.0 3.4e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 KPI89491.1 - 1.8e-08 34.1 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PH_9 PF15410.6 KPI89491.1 - 0.0022 18.3 0.0 0.065 13.6 0.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Herpes_DNAp_acc PF04929.12 KPI89491.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor PH_11 PF15413.6 KPI89491.1 - 0.013 15.9 0.4 0.14 12.6 0.4 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain DUF1636 PF07845.11 KPI89491.1 - 0.041 14.3 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1636) Pkinase_fungal PF17667.1 KPI89491.1 - 0.082 11.7 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Jnk-SapK_ap_N PF09744.9 KPI89493.1 - 0.27 11.5 0.4 1 9.5 0.0 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Ribosomal_L37e PF01907.19 KPI89494.1 - 6.7e-25 87.0 8.5 1e-24 86.4 8.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e PPR_long PF17177.4 KPI89495.1 - 1.3e-14 54.1 1.8 6e-14 51.9 0.6 2.1 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PRORP PF16953.5 KPI89495.1 - 5.7e-12 45.7 0.1 1.2e-05 25.0 0.1 3.5 4 0 0 4 4 4 2 Protein-only RNase P Nckap1 PF09735.9 KPI89495.1 - 0.14 10.1 0.1 0.21 9.5 0.1 1.1 1 0 0 1 1 1 0 Membrane-associated apoptosis protein Pribosyltran_N PF13793.6 KPI89497.1 - 4.2e-41 139.5 0.3 2.1e-40 137.3 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KPI89497.1 - 4.7e-23 82.2 0.9 3.3e-22 79.4 0.3 2.2 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KPI89497.1 - 9.5e-19 67.5 0.2 2.1e-18 66.3 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KPI89497.1 - 0.02 14.3 0.1 0.035 13.5 0.1 1.5 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase HHH_3 PF12836.7 KPI89497.1 - 0.025 14.8 0.1 4.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif zn-ribbon_14 PF16503.5 KPI89497.1 - 0.3 10.6 2.6 0.31 10.6 0.4 2.1 2 0 0 2 2 2 0 Zinc-ribbon Pho88 PF10032.9 KPI89498.1 - 1e-29 103.1 0.0 1.2e-29 102.9 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Glucos_trans_II PF14264.6 KPI89498.1 - 0.03 13.7 0.2 0.038 13.4 0.2 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII DUF1673 PF07895.11 KPI89498.1 - 0.069 12.9 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Ribosomal_L14e PF01929.17 KPI89498.1 - 0.095 13.2 0.2 0.3 11.6 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L14 CAF1C_H4-bd PF12265.8 KPI89499.1 - 3e-12 46.6 0.0 6.2e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KPI89499.1 - 0.062 14.2 8.3 0.24 12.4 0.0 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF2992 PF11208.8 KPI89499.1 - 0.73 10.1 5.0 4.5 7.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) Snf7 PF03357.21 KPI89500.1 - 1.2e-13 51.0 11.8 1.2e-13 51.0 11.8 2.0 1 1 1 2 2 2 2 Snf7 DUF1810 PF08837.11 KPI89500.1 - 0.062 13.1 0.5 0.16 11.8 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1810) FOP_dimer PF09398.10 KPI89501.1 - 1.1e-10 41.7 0.0 1.7e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 KPI89501.1 - 0.00019 20.4 0.0 0.00031 19.7 0.0 1.4 1 0 0 1 1 1 1 LisH LisH PF08513.11 KPI89501.1 - 0.0088 16.0 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 1 LisH NOG1_N PF17835.1 KPI89504.1 - 4.9e-53 179.4 0.2 9.8e-53 178.4 0.2 1.5 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 KPI89504.1 - 3.9e-28 97.0 0.0 2.1e-27 94.7 0.0 2.2 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 KPI89504.1 - 1.9e-22 79.0 5.4 4.1e-22 77.9 5.4 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 KPI89504.1 - 2.4e-17 63.0 0.0 5e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI89504.1 - 6.5e-10 38.8 0.0 1.4e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KPI89504.1 - 0.00013 21.9 0.0 0.62 10.0 0.0 2.8 2 1 0 2 2 2 2 RsgA GTPase Na_trans_cytopl PF11933.8 KPI89504.1 - 0.0041 17.0 5.9 0.0063 16.4 5.9 1.2 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Ras PF00071.22 KPI89504.1 - 0.013 15.1 0.1 0.034 13.8 0.1 1.7 1 1 0 1 1 1 0 Ras family AIG1 PF04548.16 KPI89504.1 - 0.021 14.1 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 KPI89504.1 - 0.08 13.0 0.1 5.5 7.0 0.0 2.5 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.6 KPI89504.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 KPI89504.1 - 0.14 12.1 0.1 11 5.9 0.0 2.7 2 0 0 2 2 2 0 NTPase ABC_membrane_2 PF06472.15 KPI89505.1 - 1.9e-63 214.4 2.7 2.5e-63 214.0 2.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KPI89505.1 - 2e-19 70.5 0.0 4.3e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI89505.1 - 0.00013 21.5 0.1 0.044 13.2 0.1 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KPI89505.1 - 0.00034 20.3 0.1 0.00077 19.2 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KPI89505.1 - 0.00091 19.1 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KPI89505.1 - 0.0064 17.0 0.2 0.0064 17.0 0.2 1.5 2 0 0 2 2 2 1 AAA domain PgaD PF13994.6 KPI89505.1 - 0.0092 16.0 0.0 0.48 10.5 0.0 2.4 2 0 0 2 2 2 1 PgaD-like protein FtsK_SpoIIIE PF01580.18 KPI89505.1 - 0.013 14.9 0.1 0.033 13.5 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_16 PF13191.6 KPI89505.1 - 0.016 15.6 0.0 0.029 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 KPI89505.1 - 0.061 13.2 0.0 1.2 9.1 0.0 2.7 3 0 0 3 3 3 0 NACHT domain RsgA_GTPase PF03193.16 KPI89505.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 KPI89505.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 KPI89505.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF3584 PF12128.8 KPI89505.1 - 0.2 9.1 0.4 0.3 8.5 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) eIF-5a PF01287.20 KPI89506.1 - 0.069 13.3 0.2 0.13 12.4 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Ras PF00071.22 KPI89507.1 - 4e-48 163.1 0.0 4.8e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI89507.1 - 1.7e-33 115.4 0.1 3e-33 114.6 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI89507.1 - 3.2e-16 59.3 0.0 3.8e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI89507.1 - 1.8e-06 27.5 0.0 2.3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI89507.1 - 2.6e-05 24.3 0.0 4.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI89507.1 - 0.00047 20.1 0.4 0.16 11.8 0.4 3.0 2 1 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 KPI89507.1 - 0.0013 18.3 0.1 0.015 14.8 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 KPI89507.1 - 0.0016 19.0 0.1 0.0021 18.6 0.1 1.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI89507.1 - 0.0025 18.2 0.1 0.0042 17.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 KPI89507.1 - 0.0028 17.4 1.0 0.054 13.2 0.2 2.2 1 1 0 2 2 2 1 AAA domain G-alpha PF00503.20 KPI89507.1 - 0.0045 16.2 0.9 0.5 9.5 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit ABC_tran PF00005.27 KPI89507.1 - 0.012 16.1 0.3 0.013 16.0 0.3 1.5 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 KPI89507.1 - 0.013 15.2 1.5 0.03 14.1 0.9 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain MCM PF00493.23 KPI89507.1 - 0.031 13.4 0.0 0.11 11.5 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain ATP_bind_1 PF03029.17 KPI89507.1 - 0.034 13.9 0.3 0.12 12.1 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein SRPRB PF09439.10 KPI89507.1 - 0.037 13.5 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF815 PF05673.13 KPI89507.1 - 0.04 13.1 0.2 0.096 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Ploopntkinase3 PF18751.1 KPI89507.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 IIGP PF05049.13 KPI89507.1 - 0.083 11.9 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_7 PF12775.7 KPI89507.1 - 0.093 12.2 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase PF00069.25 KPI89509.1 - 1.1e-48 165.9 0.0 1.5e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89509.1 - 1.2e-21 77.2 0.0 2.3e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI89509.1 - 0.0053 16.7 0.0 0.05 13.5 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KPI89509.1 - 0.026 13.5 0.0 0.48 9.3 0.0 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase STAT2_C PF12188.8 KPI89510.1 - 0.084 12.8 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal DER1 PF04511.15 KPI89512.1 - 7e-31 107.6 14.0 8.8e-31 107.3 14.0 1.0 1 0 0 1 1 1 1 Der1-like family DUF5432 PF17497.2 KPI89512.1 - 0.74 10.0 6.1 0.21 11.7 1.3 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5432) DOT1 PF08123.13 KPI89513.1 - 3.1e-15 56.3 0.3 4.4e-15 55.8 0.3 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 KPI89513.1 - 0.0017 19.1 0.0 0.0037 18.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KPI89513.1 - 0.003 17.1 0.1 0.0056 16.2 0.1 1.5 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 KPI89513.1 - 0.0041 16.9 0.0 0.0057 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI89513.1 - 0.012 16.3 0.0 0.026 15.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KPI89513.1 - 0.039 13.8 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain LisH PF08513.11 KPI89514.1 - 0.033 14.1 0.0 0.077 13.0 0.0 1.7 1 0 0 1 1 1 0 LisH SF3b10 PF07189.11 KPI89514.1 - 0.05 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Splicing factor 3B subunit 10 (SF3b10) BUD22 PF09073.10 KPI89514.1 - 0.97 8.7 25.5 2.1 7.6 25.5 1.5 1 0 0 1 1 1 0 BUD22 ADH_zinc_N PF00107.26 KPI89515.1 - 1.1e-19 70.7 0.0 2.3e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KPI89515.1 - 1.5e-12 48.7 0.0 2.6e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI89515.1 - 3.1e-09 36.7 0.0 1.7e-08 34.3 0.0 2.1 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PALP PF00291.25 KPI89515.1 - 0.013 15.0 0.6 0.019 14.4 0.6 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Gly_rich_SFCGS PF14272.6 KPI89515.1 - 0.046 13.7 0.6 0.11 12.6 0.1 1.8 2 0 0 2 2 2 0 Glycine-rich SFCGS TrkA_N PF02254.18 KPI89515.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain OTT_1508_deam PF14441.6 KPI89516.1 - 0.093 12.7 0.0 0.35 10.9 0.0 2.1 1 1 0 1 1 1 0 OTT_1508-like deaminase Cys_Met_Meta_PP PF01053.20 KPI89517.1 - 2.9e-90 302.6 0.0 3.3e-90 302.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KPI89517.1 - 5.9e-05 22.4 0.0 9.6e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KPI89517.1 - 0.00039 19.8 0.0 0.0007 19.0 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase CCT_2 PF09425.10 KPI89517.1 - 0.037 13.9 0.4 0.083 12.8 0.4 1.5 1 0 0 1 1 1 0 Divergent CCT motif Aminotran_5 PF00266.19 KPI89517.1 - 0.065 12.2 0.0 0.098 11.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V HEAT PF02985.22 KPI89518.1 - 1.2e-08 34.4 16.6 3.8 8.0 0.0 9.5 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 KPI89518.1 - 1.3e-06 28.7 2.5 0.011 16.2 0.3 5.5 3 1 2 5 5 5 3 HEAT repeats Vac14_Fab1_bd PF12755.7 KPI89518.1 - 0.014 16.0 1.8 22 5.7 0.0 4.2 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 KPI89518.1 - 0.047 13.7 10.4 13 5.8 0.0 5.5 7 0 0 7 7 7 0 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 KPI89518.1 - 0.098 11.7 2.9 3.4 6.7 0.1 2.9 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 KPI89518.1 - 0.42 11.2 2.2 46 4.7 0.1 4.4 3 1 1 4 4 4 0 HEAT-like repeat Pro_isomerase PF00160.21 KPI89519.1 - 1.3e-46 158.7 0.1 1.5e-46 158.5 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD YfkB PF08756.10 KPI89520.1 - 0.0058 16.4 0.1 0.0072 16.1 0.1 1.2 1 0 0 1 1 1 1 YfkB-like domain PHM7_cyt PF14703.6 KPI89520.1 - 0.0062 16.8 0.2 0.0077 16.5 0.2 1.1 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF3618 PF12277.8 KPI89520.1 - 0.15 12.3 2.3 0.37 11.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) UPF0242 PF06785.11 KPI89520.1 - 1.8 8.7 6.0 16 5.5 6.0 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PIGA PF08288.12 KPI89523.1 - 4.1e-37 126.7 0.0 7.9e-37 125.7 0.0 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.20 KPI89523.1 - 2.7e-29 101.9 0.0 4.1e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KPI89523.1 - 2.2e-27 96.1 0.5 3.6e-27 95.4 0.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 KPI89523.1 - 5.2e-23 82.0 0.0 8.7e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KPI89523.1 - 9.9e-14 52.1 0.2 1.7e-13 51.3 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Abhydrolase_5 PF12695.7 KPI89523.1 - 0.16 11.7 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family ThiI PF02568.14 KPI89524.1 - 5.6e-45 153.4 0.0 1e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Aminotran_5 PF00266.19 KPI89524.1 - 5.7e-28 97.9 0.1 1.4e-13 50.5 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V tRNA_Me_trans PF03054.16 KPI89524.1 - 9.8e-05 21.3 0.0 0.00016 20.6 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 KPI89524.1 - 0.0026 17.3 0.1 0.047 13.2 0.0 2.3 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC BAGE PF08180.11 KPI89525.1 - 0.062 13.4 0.8 6.5 6.9 0.3 2.6 2 0 0 2 2 2 0 B melanoma antigen family DNA_pol_B PF00136.21 KPI89526.1 - 1.6e-137 458.9 0.0 2.2e-137 458.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KPI89526.1 - 6.1e-70 236.0 0.0 1.1e-69 235.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KPI89526.1 - 2.8e-17 62.9 9.4 6.9e-17 61.7 9.4 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.9 KPI89526.1 - 0.035 13.8 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB zinc-ribbons_6 PF07191.12 KPI89526.1 - 0.059 13.4 6.0 0.49 10.4 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbons DNA_pol_B_2 PF03175.13 KPI89526.1 - 0.079 11.8 0.1 0.81 8.5 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral zf-RING-like PF08746.11 KPI89526.1 - 0.38 11.1 8.4 1.6 9.1 1.8 2.9 2 0 0 2 2 2 0 RING-like domain SNF2_N PF00176.23 KPI89527.1 - 2.1e-71 240.5 0.1 2.1e-71 240.5 0.1 3.3 4 2 2 6 6 6 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI89527.1 - 2.4e-20 72.9 0.0 1.3e-19 70.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SLIDE PF09111.10 KPI89527.1 - 6.7e-11 42.2 1.6 1.6e-10 41.0 1.6 1.6 1 0 0 1 1 1 1 SLIDE ResIII PF04851.15 KPI89527.1 - 6.2e-09 36.1 0.0 1.8e-08 34.6 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HAND PF09110.11 KPI89527.1 - 3.3e-06 27.8 3.1 3.3e-06 27.8 3.1 2.4 2 0 0 2 2 2 1 HAND DEAD PF00270.29 KPI89527.1 - 1.4e-05 24.9 0.0 6.5e-05 22.8 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KPI89527.1 - 0.0028 16.9 0.0 0.0077 15.4 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Pkinase PF00069.25 KPI89528.1 - 1.6e-67 227.7 0.2 6e-67 225.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89528.1 - 3.6e-39 134.6 0.0 4.9e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 KPI89528.1 - 3.7e-15 56.1 2.4 1.4e-07 31.8 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI89528.1 - 1.8e-10 39.6 0.9 0.0082 15.6 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KPI89528.1 - 4.1e-10 38.8 2.1 0.0019 18.0 0.0 4.7 3 1 0 4 4 4 2 EF-hand domain Kinase-like PF14531.6 KPI89528.1 - 2.2e-09 37.1 0.0 1.3e-08 34.5 0.0 2.0 1 1 1 2 2 2 1 Kinase-like EF-hand_8 PF13833.6 KPI89528.1 - 1e-08 34.9 2.7 0.00011 22.0 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair RIO1 PF01163.22 KPI89528.1 - 0.00015 21.4 0.4 0.00042 20.0 0.4 1.7 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 KPI89528.1 - 0.00042 19.9 0.1 0.00087 18.9 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 KPI89528.1 - 0.0009 18.3 0.2 0.0015 17.6 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KPI89528.1 - 0.0046 16.3 0.1 0.0094 15.3 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_5 PF13202.6 KPI89528.1 - 0.0057 16.1 1.3 0.074 12.6 0.0 3.1 3 0 0 3 3 3 1 EF hand TPR_12 PF13424.6 KPI89529.1 - 1.3e-23 83.1 18.1 1.4e-09 38.1 1.1 3.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 KPI89529.1 - 2.9e-13 49.0 7.1 0.01 15.6 0.0 5.5 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 KPI89529.1 - 5.5e-13 48.0 9.3 0.044 13.9 0.1 6.4 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89529.1 - 1.3e-10 40.6 2.5 0.0082 16.3 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89529.1 - 3.1e-08 33.1 7.5 4 7.7 0.1 6.0 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KPI89529.1 - 6.4e-06 25.8 3.1 0.0008 18.9 2.2 2.1 1 1 1 2 2 2 2 MalT-like TPR region RPN7 PF10602.9 KPI89529.1 - 0.00035 20.3 1.2 0.62 9.7 0.1 3.2 1 1 1 2 2 2 2 26S proteasome subunit RPN7 ANAPC5 PF12862.7 KPI89529.1 - 0.014 15.4 3.0 2.1 8.5 0.1 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_9 PF13371.6 KPI89529.1 - 0.015 15.5 3.5 0.43 10.8 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 KPI89529.1 - 0.027 14.2 1.0 0.21 11.3 0.1 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 KPI89529.1 - 0.07 13.0 1.6 50 4.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 KPI89529.1 - 0.088 12.2 2.8 1.8 7.9 0.5 2.1 1 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 KPI89529.1 - 0.29 10.9 1.6 11 5.8 0.0 3.0 3 0 0 3 3 3 0 TPR repeat TPR_16 PF13432.6 KPI89529.1 - 1.5 9.5 7.0 36 5.1 0.3 4.0 3 2 0 4 4 3 0 Tetratricopeptide repeat MIF PF01187.18 KPI89531.1 - 3.2e-11 43.5 0.0 3.5e-11 43.4 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 KPI89531.1 - 0.00064 19.6 0.0 0.77 9.7 0.0 2.2 2 0 0 2 2 2 2 Tautomerase enzyme Tsc35 PF15079.6 KPI89531.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Testis-specific protein 35 PPR_2 PF13041.6 KPI89532.1 - 2e-10 40.7 0.1 0.0006 19.9 0.0 4.0 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.6 KPI89532.1 - 2.4e-05 24.3 0.0 3.8 7.7 0.0 4.7 4 1 1 5 5 5 2 Pentatricopeptide repeat domain PPR PF01535.20 KPI89532.1 - 0.0015 18.7 0.7 33 5.0 0.0 5.1 6 0 0 6 6 6 0 PPR repeat PPR_long PF17177.4 KPI89532.1 - 0.0086 15.5 0.4 0.3 10.4 0.0 3.3 4 1 0 4 4 4 1 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 KPI89532.1 - 0.082 13.4 0.0 2.6 8.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89532.1 - 0.19 12.7 2.1 64 4.8 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 KPI89533.1 - 3.2e-47 161.1 0.0 5.5e-27 94.8 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89533.1 - 1.1e-29 103.5 1.2 2.4e-21 76.2 0.2 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase RIO1 PF01163.22 KPI89533.1 - 0.00011 21.9 0.1 0.00018 21.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KPI89533.1 - 0.07 12.5 0.4 0.12 11.7 0.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FAM220 PF15487.6 KPI89534.1 - 3.9 7.0 6.2 1.1 8.8 2.2 1.9 2 0 0 2 2 2 0 FAM220 family DUF3197 PF11432.8 KPI89535.1 - 0.055 13.4 0.0 0.27 11.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3197) PAG PF15347.6 KPI89537.1 - 0.34 9.9 0.9 0.66 8.9 0.0 1.7 2 0 0 2 2 2 0 Phosphoprotein associated with glycosphingolipid-enriched zf-U1 PF06220.12 KPI89538.1 - 8.4e-07 28.7 1.6 2e-06 27.4 1.6 1.6 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.8 KPI89538.1 - 0.018 15.3 0.3 0.046 14.0 0.3 1.7 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KPI89538.1 - 0.069 13.6 0.9 1.4 9.5 0.5 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Vps51 PF08700.11 KPI89539.1 - 1.4e-24 86.0 1.0 6.2e-24 83.9 0.3 2.5 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.6 KPI89539.1 - 1.6e-05 24.8 0.0 2.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec5 COG2 PF06148.11 KPI89539.1 - 5.4e-05 23.3 1.5 5.4e-05 23.3 1.5 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Dor1 PF04124.12 KPI89539.1 - 9.5e-05 21.2 5.0 0.00012 20.9 3.4 1.9 2 0 0 2 2 2 1 Dor1-like family CENP-F_leu_zip PF10473.9 KPI89539.1 - 0.01 15.9 1.3 0.038 14.0 1.3 2.0 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG5 PF10392.9 KPI89539.1 - 0.013 15.6 2.1 0.013 15.6 2.1 2.5 3 0 0 3 3 3 0 Golgi transport complex subunit 5 CK2S PF15011.6 KPI89539.1 - 0.022 14.6 4.1 0.064 13.1 0.6 2.8 2 0 0 2 2 2 0 Casein Kinase 2 substrate Vps53_N PF04100.12 KPI89539.1 - 0.066 12.2 5.7 0.02 13.9 2.6 1.6 2 0 0 2 2 2 0 Vps53-like, N-terminal Vps54_N PF10475.9 KPI89539.1 - 0.079 12.2 2.5 0.2 10.9 2.5 1.6 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex BLOC1_2 PF10046.9 KPI89539.1 - 0.13 12.6 0.2 0.58 10.5 0.2 2.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 KPI89539.1 - 0.5 10.5 3.5 0.8 9.9 1.9 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4795 PF16043.5 KPI89539.1 - 1.2 8.6 4.3 0.59 9.7 1.3 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) Peptidase_M16 PF00675.20 KPI89540.1 - 1.8e-08 34.5 0.0 3.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KPI89540.1 - 0.0044 17.1 0.0 0.042 13.8 0.0 2.4 2 1 0 2 2 2 1 Peptidase M16 inactive domain MCU PF04678.13 KPI89541.1 - 7.1e-24 84.9 0.3 8.7e-24 84.6 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter CCDC92 PF14916.6 KPI89542.1 - 0.021 14.6 1.5 0.022 14.5 0.1 1.7 2 0 0 2 2 2 0 Coiled-coil domain of unknown function RPAP2_Rtr1 PF04181.13 KPI89543.1 - 8e-06 26.1 0.1 0.00011 22.5 0.1 2.3 1 1 0 1 1 1 1 Rtr1/RPAP2 family TNV_CP PF03898.13 KPI89543.1 - 0.096 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein DUF667 PF05018.13 KPI89544.1 - 2.5e-92 307.7 0.5 2.9e-92 307.5 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) UCH PF00443.29 KPI89546.1 - 3.2e-46 157.9 0.4 4.2e-46 157.5 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI89546.1 - 2.2e-18 66.9 6.0 4.9e-18 65.8 6.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3770 PF12603.8 KPI89546.1 - 1.8 8.0 6.1 2.1 7.8 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3770) Piwi PF02171.17 KPI89547.1 - 1.9e-12 47.1 0.0 3.4e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Piwi domain Pyr_redox_2 PF07992.14 KPI89548.1 - 2.5e-09 36.8 0.1 2e-06 27.3 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI89548.1 - 4.4e-05 23.6 0.0 0.00011 22.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KPI89548.1 - 5.7e-05 23.6 0.4 0.73 10.4 0.0 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KPI89548.1 - 0.00058 19.1 0.0 0.017 14.3 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 KPI89548.1 - 0.00083 19.4 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 KPI89548.1 - 0.0053 16.0 0.0 0.021 14.1 0.0 1.9 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 KPI89548.1 - 0.0062 16.2 0.0 0.044 13.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KPI89548.1 - 0.042 12.9 0.0 0.12 11.4 0.0 1.7 1 0 0 1 1 1 0 Lycopene cyclase protein MRP-S31 PF15433.6 KPI89549.1 - 0.038 13.7 2.3 0.053 13.2 2.3 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 ISG65-75 PF11727.8 KPI89549.1 - 2.7 7.1 6.5 4.1 6.6 6.5 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein TMEM189_B_dmain PF10520.9 KPI89550.1 - 7.2e-66 221.6 1.7 9.5e-66 221.2 1.7 1.1 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain IBV_3A PF03617.13 KPI89550.1 - 0.018 15.0 0.6 0.038 14.0 0.6 1.5 1 0 0 1 1 1 0 IBV 3A protein Vps35 PF03635.17 KPI89553.1 - 1.1e-195 652.3 0.0 2.7e-121 406.4 0.0 2.0 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 35 HMMR_N PF15905.5 KPI89554.1 - 0.0051 16.3 6.6 0.0051 16.3 6.6 2.9 2 1 1 3 3 3 1 Hyaluronan mediated motility receptor N-terminal NPV_P10 PF05531.12 KPI89554.1 - 0.034 14.6 0.1 0.034 14.6 0.1 3.2 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein GAS PF13851.6 KPI89554.1 - 0.047 13.0 28.1 0.14 11.5 8.3 4.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Peripla_BP_4 PF13407.6 KPI89554.1 - 0.063 12.8 0.3 0.14 11.7 0.3 1.6 1 0 0 1 1 1 0 Periplasmic binding protein domain Hs1pro-1_C PF07014.12 KPI89554.1 - 0.068 12.6 2.1 0.76 9.2 0.7 2.2 1 1 1 2 2 2 0 Hs1pro-1 protein C-terminus ATG16 PF08614.11 KPI89554.1 - 0.14 12.4 39.3 2.9 8.1 8.6 3.7 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 KPI89554.1 - 0.18 11.8 0.1 0.18 11.8 0.1 4.3 4 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding EzrA PF06160.12 KPI89554.1 - 0.57 8.3 6.2 0.051 11.7 1.0 1.9 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Fmp27_WPPW PF10359.9 KPI89554.1 - 0.6 8.9 5.4 1.3 7.8 0.3 2.4 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Spc7 PF08317.11 KPI89554.1 - 5.7 5.7 29.5 0.36 9.7 5.1 3.4 2 1 0 3 3 3 0 Spc7 kinetochore protein DnaJ_C PF01556.18 KPI89555.1 - 3.9e-30 104.9 0.0 5.6e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI89555.1 - 3.1e-27 94.5 1.7 5.3e-27 93.7 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KPI89555.1 - 8.1e-14 51.7 15.4 1.5e-13 50.9 15.4 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI89555.1 - 0.0027 17.6 8.0 0.28 11.2 1.1 2.6 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DZR PF12773.7 KPI89555.1 - 0.045 13.8 8.5 0.15 12.1 0.9 2.4 2 0 0 2 2 2 0 Double zinc ribbon TackOD1 PF18551.1 KPI89555.1 - 0.12 12.0 5.8 0.44 10.2 0.6 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 HypA PF01155.19 KPI89555.1 - 0.22 11.6 6.8 2.1 8.4 1.7 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2614 PF11023.8 KPI89555.1 - 0.22 11.6 0.2 0.22 11.6 0.2 2.3 3 0 0 3 3 3 0 Zinc-ribbon containing domain PQQ_3 PF13570.6 KPI89559.1 - 0.008 16.6 2.0 0.4 11.2 0.1 3.5 3 0 0 3 3 3 1 PQQ-like domain Shisa PF13908.6 KPI89560.1 - 0.0061 16.8 0.1 0.0086 16.3 0.0 1.3 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator TPR_19 PF14559.6 KPI89561.1 - 9.2e-15 54.9 19.6 0.0005 20.5 0.0 7.0 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89561.1 - 1.5e-11 44.1 43.9 0.025 15.4 0.0 10.1 8 3 3 11 11 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 KPI89561.1 - 1.5e-10 40.4 26.3 0.21 11.8 0.1 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 KPI89561.1 - 5.1e-07 29.2 16.0 0.096 12.6 0.2 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI89561.1 - 0.0012 19.1 27.7 1.5 9.2 2.8 6.6 5 2 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89561.1 - 0.0018 18.2 11.4 3.1 8.0 0.2 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 KPI89561.1 - 0.0019 18.7 1.7 12 6.7 0.0 4.9 4 0 0 4 4 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KPI89561.1 - 0.014 15.0 4.1 1.6 8.4 0.1 4.2 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.7 KPI89561.1 - 0.068 13.4 22.8 0.022 15.0 1.4 5.1 4 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Exonuc_VII_L PF02601.15 KPI89561.1 - 0.1 12.1 0.6 0.22 11.1 0.6 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPR_9 PF13371.6 KPI89561.1 - 0.14 12.3 0.1 0.14 12.3 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 KPI89561.1 - 0.2 11.7 0.1 6.6 6.8 0.0 2.9 3 0 0 3 3 3 0 Putative TPR-like repeat TPR_11 PF13414.6 KPI89561.1 - 0.3 10.8 16.1 1.1 9.0 0.1 5.3 6 0 0 6 6 6 0 TPR repeat TPR_10 PF13374.6 KPI89561.1 - 1 9.3 24.1 0.35 10.8 0.4 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89561.1 - 1.4 9.3 11.3 30 5.2 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat La PF05383.17 KPI89562.1 - 2e-22 79.0 0.0 3.4e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 La domain RRM_7 PF16367.5 KPI89562.1 - 3.6e-05 23.8 0.1 0.0015 18.7 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif RRM_1 PF00076.22 KPI89562.1 - 0.00042 20.1 0.4 0.042 13.7 0.0 3.2 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KPI89562.1 - 0.0021 18.1 1.9 0.0047 17.0 0.1 2.3 2 1 0 2 2 2 1 RNA binding motif Pallilysin PF18663.1 KPI89562.1 - 0.18 11.8 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Pallilysin beta barrel domain Biotin_lipoyl PF00364.22 KPI89563.1 - 1.6e-29 101.5 2.1 1.3e-13 50.6 0.2 2.4 2 0 0 2 2 2 2 Biotin-requiring enzyme HlyD_3 PF13437.6 KPI89563.1 - 0.00015 22.4 0.2 1.3 9.7 0.0 3.0 2 1 1 3 3 3 2 HlyD family secretion protein QRPTase_N PF02749.16 KPI89563.1 - 0.00087 19.3 1.2 6.2 7.0 0.1 3.8 2 2 2 4 4 4 3 Quinolinate phosphoribosyl transferase, N-terminal domain PYNP_C PF07831.13 KPI89563.1 - 0.0011 18.6 0.3 2.2 8.0 0.0 2.6 2 0 0 2 2 2 2 Pyrimidine nucleoside phosphorylase C-terminal domain Biotin_lipoyl_2 PF13533.6 KPI89563.1 - 0.0023 17.7 0.0 10 6.1 0.0 3.5 3 0 0 3 3 3 2 Biotin-lipoyl like DUF2118 PF09891.9 KPI89563.1 - 0.0031 17.5 0.2 3.5 7.6 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2118) TPR_17 PF13431.6 KPI89563.1 - 0.0082 16.4 0.1 8.8 7.0 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2779 PF11074.8 KPI89563.1 - 0.012 16.0 0.0 2.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function(DUF2779) DUF2604 PF10790.9 KPI89563.1 - 1.2 9.4 4.4 37 4.7 1.5 3.2 2 2 0 2 2 2 0 Protein of Unknown function (DUF2604) DUF3597 PF12200.8 KPI89563.1 - 5.3 7.6 18.4 0.13 12.8 0.6 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3597) ISPD_C PF18706.1 KPI89564.1 - 0.012 15.2 0.2 0.015 15.0 0.2 1.1 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain Mt_ATP-synt_B PF05405.14 KPI89564.1 - 0.2 11.3 2.0 10 5.7 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4574 PF15141.6 KPI89564.1 - 0.24 11.3 1.8 0.82 9.6 0.2 2.0 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 EBP50_C PF09007.11 KPI89565.1 - 6.3 7.8 9.1 11 7.0 5.0 2.4 2 0 0 2 2 2 0 EBP50, C-terminal DEAD PF00270.29 KPI89569.1 - 1.7e-16 60.5 0.0 3.7e-12 46.4 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI89569.1 - 1.4e-15 57.6 0.1 2.1e-14 53.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI89569.1 - 0.0013 18.8 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PPL5 PF18168.1 KPI89569.1 - 0.032 13.5 1.0 0.072 12.4 1.0 1.5 1 0 0 1 1 1 0 Prim-pol family 5 SecA_DEAD PF07517.14 KPI89569.1 - 0.14 11.4 0.6 0.24 10.7 0.1 1.6 2 0 0 2 2 2 0 SecA DEAD-like domain IMS PF00817.20 KPI89570.1 - 9.8e-37 126.3 0.0 2.2e-36 125.1 0.0 1.6 2 0 0 2 2 2 1 impB/mucB/samB family IMS_HHH PF11798.8 KPI89570.1 - 0.02 15.2 0.0 0.045 14.1 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif PGM_PMM_I PF02878.16 KPI89571.1 - 3.3e-30 104.6 0.1 5.1e-30 104.0 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KPI89571.1 - 2.2e-24 85.8 0.0 3.9e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KPI89571.1 - 3.1e-10 40.6 0.1 1.3e-09 38.6 0.1 2.1 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KPI89571.1 - 3.3e-08 33.6 0.0 7.8e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ParA PF10609.9 KPI89573.1 - 1.1e-86 290.3 0.0 1.3e-86 290.1 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KPI89573.1 - 2.4e-12 47.0 0.0 3.3e-11 43.4 0.0 2.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KPI89573.1 - 2.8e-07 30.6 0.3 2.4e-06 27.6 0.3 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 KPI89573.1 - 9.3e-07 28.4 0.0 1.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 KPI89573.1 - 0.00027 20.2 0.4 0.00059 19.1 0.1 1.7 2 0 0 2 2 2 1 Anion-transporting ATPase MeaB PF03308.16 KPI89573.1 - 0.0034 16.4 0.3 0.0052 15.8 0.3 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 KPI89573.1 - 0.0089 15.9 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 KPI89573.1 - 0.011 15.5 0.1 0.019 14.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KPI89573.1 - 0.019 15.4 0.1 0.035 14.5 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 KPI89573.1 - 0.022 14.0 0.2 0.041 13.1 0.2 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_26 PF13500.6 KPI89573.1 - 0.024 14.5 0.3 0.15 11.9 0.3 2.3 1 1 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 KPI89573.1 - 0.033 13.7 0.2 0.06 12.8 0.2 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_18 PF13238.6 KPI89573.1 - 0.051 14.1 0.0 0.074 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KPI89573.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 KPI89573.1 - 0.08 12.5 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KPI89573.1 - 0.085 12.6 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 KPI89573.1 - 0.14 12.2 0.2 0.24 11.4 0.2 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CLP1_P PF16575.5 KPI89573.1 - 0.14 11.9 0.0 0.52 10.1 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SMC_N PF02463.19 KPI89573.1 - 0.16 11.3 0.1 0.26 10.7 0.1 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain TsaE PF02367.17 KPI89573.1 - 0.2 11.7 0.2 0.33 10.9 0.2 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 KPI89573.1 - 0.2 11.5 0.4 0.36 10.7 0.4 1.4 1 0 0 1 1 1 0 NTPase SRP54 PF00448.22 KPI89573.1 - 0.21 11.2 0.6 0.43 10.2 0.2 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 KPI89573.1 - 0.21 12.0 0.2 0.37 11.2 0.2 1.3 1 0 0 1 1 1 0 RNA helicase CBP_BcsQ PF06564.12 KPI89573.1 - 0.22 10.9 0.1 0.59 9.6 0.1 1.6 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ NACHT PF05729.12 KPI89573.1 - 0.27 11.1 0.5 0.45 10.4 0.5 1.3 1 0 0 1 1 1 0 NACHT domain MSC PF09402.10 KPI89573.1 - 0.56 9.6 3.6 0.8 9.1 3.6 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Lactamase_B PF00753.27 KPI89574.1 - 4.4e-17 62.8 1.5 6.4e-17 62.2 0.8 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 KPI89574.1 - 1.7e-09 37.5 0.6 3.7e-09 36.4 0.1 1.8 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 KPI89574.1 - 2.4e-05 23.9 0.0 5.8e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KPI89574.1 - 0.012 15.5 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Hist_deacetyl PF00850.19 KPI89575.1 - 1.7e-67 228.1 0.3 8.2e-67 225.8 0.1 1.8 2 0 0 2 2 2 1 Histone deacetylase domain DSPc PF00782.20 KPI89577.1 - 3.2e-19 69.1 0.0 4.9e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ABC_tran PF00005.27 KPI89578.1 - 7.7e-36 123.6 0.0 8.7e-18 65.2 0.0 2.7 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 KPI89578.1 - 1.1e-12 48.5 3.3 0.0066 16.3 0.0 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI89578.1 - 3.7e-10 39.6 0.9 0.065 12.7 0.0 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain RLI PF04068.15 KPI89578.1 - 1.1e-09 37.9 6.1 3.2e-09 36.4 6.1 1.9 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.27 KPI89578.1 - 1.4e-07 31.0 3.0 1.4e-07 31.0 3.0 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_15 PF13175.6 KPI89578.1 - 2.2e-06 27.7 0.8 0.035 13.8 1.6 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 KPI89578.1 - 2.6e-06 27.9 0.0 0.0041 17.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 KPI89578.1 - 3.5e-05 23.4 0.2 0.18 11.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_6 PF12837.7 KPI89578.1 - 0.00011 22.1 3.0 0.00011 22.1 3.0 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_22 PF13401.6 KPI89578.1 - 0.00021 21.5 0.1 0.043 14.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KPI89578.1 - 0.00033 20.9 0.0 1.2 9.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 KPI89578.1 - 0.00034 20.5 0.0 0.15 12.0 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase Fer4_21 PF14697.6 KPI89578.1 - 0.00045 20.3 17.2 0.0011 19.0 17.2 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain AAA_23 PF13476.6 KPI89578.1 - 0.00051 20.6 5.7 0.019 15.5 0.2 2.7 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 KPI89578.1 - 0.00053 19.9 0.3 0.012 15.5 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 KPI89578.1 - 0.00063 20.2 0.1 0.047 14.1 0.0 2.9 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Fer4_7 PF12838.7 KPI89578.1 - 0.00094 19.7 0.2 0.00094 19.7 0.2 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 KPI89578.1 - 0.0018 18.3 1.5 0.0018 18.3 1.5 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_30 PF13604.6 KPI89578.1 - 0.002 17.9 0.0 2.3 7.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KPI89578.1 - 0.0022 18.3 0.0 0.5 10.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Rad17 PF03215.15 KPI89578.1 - 0.0028 17.6 0.0 0.79 9.6 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain SRP54 PF00448.22 KPI89578.1 - 0.0048 16.6 0.3 0.61 9.7 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_7 PF12775.7 KPI89578.1 - 0.0075 15.8 0.1 0.31 10.5 0.0 2.6 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 KPI89578.1 - 0.0078 16.0 0.1 0.98 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI89578.1 - 0.0078 16.2 0.3 0.74 9.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) TsaE PF02367.17 KPI89578.1 - 0.012 15.6 0.0 0.051 13.6 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 KPI89578.1 - 0.012 15.6 0.0 3.2 7.9 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 KPI89578.1 - 0.016 15.8 0.0 6.9 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KPI89578.1 - 0.018 14.6 0.1 3.3 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KPI89578.1 - 0.022 14.9 0.8 4.2 7.5 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.6 KPI89578.1 - 0.029 14.4 0.2 1.1 9.4 0.0 2.9 3 0 0 3 3 2 0 AAA domain Fer4_3 PF12798.7 KPI89578.1 - 0.031 15.2 4.0 0.031 15.2 4.0 2.7 2 0 0 2 2 1 0 4Fe-4S binding domain Fer4_2 PF12797.7 KPI89578.1 - 0.033 14.3 1.1 0.033 14.3 1.1 3.1 2 1 0 2 2 1 0 4Fe-4S binding domain Roc PF08477.13 KPI89578.1 - 0.036 14.3 0.0 0.26 11.5 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 KPI89578.1 - 0.08 13.3 0.2 2.6 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 KPI89578.1 - 0.082 12.5 0.1 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 KPI89578.1 - 0.14 12.3 14.9 0.41 10.9 14.9 1.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain NB-ARC PF00931.22 KPI89578.1 - 0.15 11.2 0.2 7.1 5.7 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain DUF3245 PF11595.8 KPI89578.1 - 0.17 12.4 10.8 0.27 11.7 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) TniB PF05621.11 KPI89578.1 - 0.2 11.1 0.4 11 5.3 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein PduV-EutP PF10662.9 KPI89578.1 - 0.37 10.5 1.5 1.2 8.9 0.0 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation VEFS-Box PF09733.9 KPI89578.1 - 1.3 8.8 8.5 11 5.9 0.1 2.6 2 0 0 2 2 2 0 VEFS-Box of polycomb protein EF-hand_6 PF13405.6 KPI89579.1 - 1e-06 28.2 0.0 0.0038 17.0 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KPI89579.1 - 0.00015 21.0 0.0 0.0065 15.9 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 KPI89579.1 - 0.00099 19.5 0.0 0.32 11.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair K-box PF01486.17 KPI89579.1 - 0.15 12.3 0.4 0.26 11.5 0.4 1.3 1 0 0 1 1 1 0 K-box region Stork_head PF10264.9 KPI89580.1 - 0.017 15.3 0.3 0.15 12.3 0.1 2.1 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain Tn7_Tnp_TnsA_C PF08721.11 KPI89580.1 - 0.13 13.0 0.1 0.41 11.3 0.0 1.9 2 0 0 2 2 2 0 TnsA endonuclease C terminal Leu_Phe_trans PF03588.14 KPI89581.1 - 0.00049 19.7 1.1 0.0015 18.1 0.1 2.3 3 0 0 3 3 3 1 Leucyl/phenylalanyl-tRNA protein transferase Ribosomal_L36e PF01158.18 KPI89582.1 - 8e-28 96.5 3.7 9.3e-28 96.3 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e ATP-synt_C PF00137.21 KPI89583.1 - 7.4e-09 35.8 13.5 1.4e-08 34.9 13.5 1.5 1 0 0 1 1 1 1 ATP synthase subunit C ATP_transf PF09830.9 KPI89583.1 - 0.072 13.2 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 ATP adenylyltransferase PCI PF01399.27 KPI89585.1 - 2.4e-13 50.5 0.5 1.1e-12 48.4 0.0 2.4 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 KPI89585.1 - 0.0054 16.8 0.3 0.0054 16.8 0.3 2.8 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN5 C-terminal domain Vps39_1 PF10366.9 KPI89585.1 - 0.12 12.7 5.6 4.1 7.7 0.1 3.8 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 1 Sec34 PF04136.15 KPI89585.1 - 6.3 6.7 10.4 6.7 6.6 0.3 4.1 3 2 1 4 4 4 0 Sec34-like family Ribosomal_S5_C PF03719.15 KPI89587.1 - 8.3e-25 86.0 0.0 1.3e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KPI89587.1 - 1.9e-22 79.0 0.5 2.8e-22 78.5 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF1279 PF06916.13 KPI89588.1 - 3.2e-05 24.4 0.1 4.9e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) WW PF00397.26 KPI89588.1 - 0.016 15.3 0.1 0.031 14.4 0.1 1.5 1 0 0 1 1 1 0 WW domain Ribosomal_L22 PF00237.19 KPI89589.1 - 4e-31 107.3 0.3 5e-31 107.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Kinesin PF00225.23 KPI89590.1 - 1.4e-28 99.8 0.0 2e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain MORN PF02493.20 KPI89590.1 - 9.6e-12 44.1 32.9 0.00022 20.9 0.1 7.3 7 0 0 7 7 7 4 MORN repeat Microtub_bd PF16796.5 KPI89590.1 - 5.9e-10 39.3 0.0 9.5e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding TPR_16 PF13432.6 KPI89591.1 - 0.06 14.0 0.5 0.06 14.0 0.5 6.6 5 3 1 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89591.1 - 0.075 13.9 13.0 1.2 10.2 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 KPI89591.1 - 0.1 12.8 17.8 1 9.7 0.0 7.9 9 0 0 9 9 9 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 KPI89591.1 - 0.16 12.4 2.4 2.4 8.6 0.3 3.1 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_1 PF00515.28 KPI89591.1 - 0.64 9.9 3.7 51 3.9 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 KPI89591.1 - 7.2 6.8 15.1 5.1 7.3 0.2 4.9 4 2 0 5 5 5 0 Tetratricopeptide repeat DEAD PF00270.29 KPI89592.1 - 5.9e-48 162.9 0.0 2.3e-47 161.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI89592.1 - 1.8e-31 108.8 0.0 3.6e-30 104.6 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KPI89592.1 - 0.0011 18.3 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 KPI89592.1 - 0.083 13.2 0.1 0.65 10.3 0.1 2.2 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 KPI89592.1 - 0.12 12.3 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ELO PF01151.18 KPI89593.1 - 6e-73 245.4 19.9 7e-73 245.2 19.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family JAB PF01398.21 KPI89594.1 - 6.9e-25 87.3 0.0 5.8e-24 84.3 0.0 2.1 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KPI89594.1 - 4e-17 62.6 0.3 8.7e-17 61.6 0.3 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function ASL_C PF08328.11 KPI89594.1 - 0.069 13.2 0.5 6.3 6.9 0.2 2.4 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal RHD3 PF05879.12 KPI89596.1 - 2.1e-104 350.2 0.7 2.9e-89 300.2 0.1 3.5 1 1 2 3 3 3 3 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 KPI89596.1 - 1.9e-05 24.8 0.0 4.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 KPI89596.1 - 0.0018 18.5 0.0 0.0067 16.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 KPI89596.1 - 0.018 15.1 0.0 0.047 13.8 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase FliH PF02108.16 KPI89596.1 - 0.078 13.0 0.3 0.19 11.8 0.3 1.6 1 0 0 1 1 1 0 Flagellar assembly protein FliH Ion_trans PF00520.31 KPI89596.1 - 0.99 8.6 4.4 1.9 7.6 4.4 1.4 1 0 0 1 1 1 0 Ion transport protein ARL2_Bind_BART PF11527.8 KPI89599.1 - 0.0031 17.6 0.0 0.0069 16.5 0.0 1.5 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART RWP-RK PF02042.15 KPI89600.1 - 0.25 11.4 1.9 0.56 10.2 0.1 2.5 2 0 0 2 2 2 0 RWP-RK domain TPR_19 PF14559.6 KPI89602.1 - 1.3e-07 32.0 8.3 0.36 11.4 0.0 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89602.1 - 1.3e-05 24.9 6.3 1.3 9.2 0.2 6.4 5 0 0 5 5 5 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 KPI89602.1 - 4.6e-05 22.6 0.3 0.024 13.7 0.0 3.0 2 1 0 2 2 2 2 Coatomer WD associated region Clathrin PF00637.20 KPI89602.1 - 0.00023 21.0 1.0 1.2 9.0 0.0 4.5 4 2 0 4 4 4 2 Region in Clathrin and VPS TPR_1 PF00515.28 KPI89602.1 - 0.0089 15.8 5.8 0.23 11.3 0.2 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89602.1 - 0.011 15.9 5.0 4.8 7.6 0.0 6.0 8 0 0 8 8 8 0 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 KPI89602.1 - 0.03 14.6 0.0 0.77 10.1 0.0 3.3 3 1 0 3 3 2 0 Anaphase-promoting complex subunit 4 WD40 domain FBPase PF00316.20 KPI89602.1 - 0.071 12.6 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain TPR_14 PF13428.6 KPI89602.1 - 0.087 13.7 25.9 11 7.2 0.1 9.8 9 2 1 10 10 10 0 Tetratricopeptide repeat PPR_2 PF13041.6 KPI89602.1 - 0.15 12.3 0.0 3.2 8.0 0.0 3.1 2 0 0 2 2 2 0 PPR repeat family Nucleoporin_N PF08801.11 KPI89602.1 - 0.18 10.5 0.0 0.32 9.7 0.0 1.3 1 0 0 1 1 1 0 Nup133 N terminal like PPR PF01535.20 KPI89602.1 - 0.22 11.9 1.7 43 4.7 0.0 5.4 6 0 0 6 6 6 0 PPR repeat TPR_2 PF07719.17 KPI89602.1 - 0.38 11.0 23.0 0.077 13.1 0.6 8.1 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI89602.1 - 2.8 8.3 17.8 1.7 9.0 0.2 6.6 7 1 1 8 8 8 0 Tetratricopeptide repeat LRR_8 PF13855.6 KPI89603.1 - 4e-11 42.5 14.1 3.7e-06 26.6 5.2 5.4 4 1 1 5 5 5 2 Leucine rich repeat LRR_4 PF12799.7 KPI89603.1 - 9.2e-10 38.6 14.9 5.2e-05 23.5 2.5 4.8 3 2 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI89603.1 - 3.8e-06 26.5 1.5 0.36 10.3 0.0 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KPI89603.1 - 0.0028 18.0 9.2 0.37 11.5 0.4 6.1 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.6 KPI89603.1 - 5.3 7.4 15.5 19 5.6 0.1 6.0 7 0 0 7 7 7 0 Leucine Rich repeat Wzz PF02706.15 KPI89604.1 - 0.1 12.9 0.5 0.2 12.0 0.5 1.4 1 0 0 1 1 1 0 Chain length determinant protein B9-C2 PF07162.11 KPI89605.1 - 1.2e-27 97.1 0.0 1.5e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Pkinase PF00069.25 KPI89607.1 - 2.5e-66 223.7 0.0 3.7e-66 223.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89607.1 - 1.5e-48 165.4 0.0 2.3e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89607.1 - 2.2e-05 23.9 0.0 5.3e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Kinase-like LRR_6 PF13516.6 KPI89609.1 - 0.0013 18.6 2.3 32 4.9 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat LRR_4 PF12799.7 KPI89609.1 - 0.0041 17.5 7.6 12 6.5 0.0 4.9 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) AAA_13 PF13166.6 KPI89609.1 - 0.37 9.4 4.2 0.57 8.8 4.2 1.2 1 0 0 1 1 1 0 AAA domain FAM76 PF16046.5 KPI89609.1 - 0.88 8.9 4.5 1.6 8.0 4.5 1.3 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 KPI89609.1 - 1.3 8.1 8.7 3 6.9 8.7 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LRR_8 PF13855.6 KPI89609.1 - 2.7 7.8 8.7 20 5.1 0.0 4.6 5 0 0 5 5 5 0 Leucine rich repeat Dynein_light PF01221.18 KPI89610.1 - 6.7e-41 138.5 0.9 7.5e-41 138.4 0.9 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Peptidase_C3 PF00548.20 KPI89610.1 - 0.018 15.0 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) Imm48 PF15574.6 KPI89610.1 - 0.065 13.0 0.1 0.087 12.6 0.1 1.1 1 0 0 1 1 1 0 Immunity protein 48 Ectatomin PF06457.11 KPI89610.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Ectatomin LIN37 PF15306.6 KPI89611.1 - 0.018 15.3 0.2 0.065 13.4 0.2 1.9 1 0 0 1 1 1 0 LIN37 Rtt106 PF08512.12 KPI89612.1 - 5.3e-12 46.0 0.0 5.7e-11 42.7 0.0 2.4 2 0 0 2 2 2 1 Histone chaperone Rttp106-like SSrecog PF03531.14 KPI89612.1 - 1.1e-05 25.3 0.0 6.2e-05 22.8 0.0 2.5 2 1 0 2 2 2 1 Structure-specific recognition protein (SSRP1) Cwf_Cwc_15 PF04889.12 KPI89612.1 - 0.0015 18.3 32.4 0.0027 17.5 32.4 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Nop53 PF07767.11 KPI89612.1 - 0.0018 17.8 28.1 0.0025 17.3 28.1 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Nop14 PF04147.12 KPI89612.1 - 0.011 13.9 39.1 0.015 13.6 39.1 1.1 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 KPI89612.1 - 0.028 14.5 41.2 0.042 14.0 41.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DNA_pol_phi PF04931.13 KPI89612.1 - 0.045 11.9 32.7 0.072 11.2 32.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 KPI89612.1 - 0.056 13.3 21.3 0.097 12.5 21.3 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.14 KPI89612.1 - 0.11 10.7 36.3 0.15 10.3 36.3 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 KPI89612.1 - 0.18 11.1 29.6 0.25 10.6 29.6 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 KPI89612.1 - 0.36 10.2 37.0 0.49 9.8 37.0 1.2 1 0 0 1 1 1 0 SDA1 Apt1 PF10351.9 KPI89612.1 - 4.2 6.1 16.6 6.1 5.6 16.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SURF2 PF05477.11 KPI89612.1 - 4.5 6.9 21.9 7.3 6.2 21.9 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RNA_polI_A34 PF08208.11 KPI89612.1 - 5.6 7.0 34.6 12 5.9 34.6 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Presenilin PF01080.17 KPI89612.1 - 6.9 5.3 15.4 10 4.7 15.4 1.2 1 0 0 1 1 1 0 Presenilin Herpes_UL6 PF01763.16 KPI89613.1 - 0.017 13.7 1.3 0.028 13.0 0.9 1.5 1 1 0 1 1 1 0 Herpesvirus UL6 like AAA_assoc_2 PF16193.5 KPI89613.1 - 0.049 14.0 1.1 2.1 8.7 0.1 3.0 3 0 0 3 3 3 0 AAA C-terminal domain AJAP1_PANP_C PF15298.6 KPI89613.1 - 0.085 13.1 3.9 0.15 12.3 0.1 2.3 2 0 0 2 2 2 0 AJAP1/PANP C-terminus GIT_CC PF16559.5 KPI89613.1 - 1.3 9.0 5.4 0.49 10.3 0.2 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF148 PF02520.17 KPI89613.1 - 3.9 7.6 7.8 0.35 11.0 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF148 NPV_P10 PF05531.12 KPI89613.1 - 6.8 7.2 8.7 19 5.8 0.1 4.0 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein GCM PF03615.15 KPI89614.1 - 0.2 11.6 0.0 0.8 9.6 0.0 2.0 2 0 0 2 2 2 0 GCM motif protein LRR_9 PF14580.6 KPI89616.1 - 6.7e-21 74.6 1.4 1.2e-20 73.7 1.4 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KPI89616.1 - 0.1 12.3 2.7 13 5.6 0.0 3.1 2 2 0 2 2 2 0 Leucine rich repeat Dynactin_p22 PF07426.11 KPI89616.1 - 0.11 12.3 0.9 0.26 11.1 0.9 1.6 1 0 0 1 1 1 0 Dynactin subunit p22 TipAS PF07739.13 KPI89616.1 - 0.15 12.6 1.0 11 6.6 0.8 2.3 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain CCDC-167 PF15188.6 KPI89616.1 - 0.54 10.6 4.2 0.67 10.3 1.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF1079 PF06435.11 KPI89617.1 - 0.092 13.0 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1079) Utp14 PF04615.13 KPI89619.1 - 2e-113 380.5 46.8 2e-113 380.5 46.8 2.2 1 1 1 2 2 2 1 Utp14 protein DUF2167 PF09935.9 KPI89619.1 - 5.2 6.2 7.6 3.2 6.9 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2167) Arm PF00514.23 KPI89620.1 - 1e-41 139.7 15.4 5.8e-08 32.5 0.0 16.1 16 1 0 16 16 16 8 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KPI89620.1 - 5.8e-08 32.5 0.0 0.036 13.5 0.0 5.3 6 1 1 7 7 7 2 Armadillo-like Bombinin PF05298.11 KPI89620.1 - 0.037 13.7 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 Bombinin HEAT PF02985.22 KPI89620.1 - 0.04 14.2 4.6 17 6.0 0.0 5.3 5 0 0 5 5 5 0 HEAT repeat Pkinase PF00069.25 KPI89622.1 - 6.8e-57 192.8 0.0 9.2e-57 192.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89622.1 - 3.9e-29 101.7 0.0 5.9e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KPI89622.1 - 2.1e-06 27.3 0.0 3.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI89622.1 - 4.4e-06 25.7 0.0 2.9e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KPI89622.1 - 0.00013 21.4 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KPI89622.1 - 0.0048 15.9 0.0 0.0079 15.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KPI89622.1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KPI89622.1 - 0.035 13.7 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Mito_carr PF00153.27 KPI89623.1 - 1.1e-40 137.5 2.0 2.8e-15 56.0 0.0 4.4 3 2 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 KPI89623.1 - 0.0034 16.6 0.0 1.5 7.9 0.0 2.2 2 0 0 2 2 2 2 Gammaproteobacterial serine protease NIF PF03031.18 KPI89624.1 - 6.4e-21 74.8 0.0 7.6e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Clat_adaptor_s PF01217.20 KPI89625.1 - 2e-31 108.9 2.5 1.9e-30 105.6 2.5 1.9 1 1 0 1 1 1 1 Clathrin adaptor complex small chain MRG PF05712.13 KPI89625.1 - 0.011 15.1 0.1 0.014 14.8 0.1 1.3 1 0 0 1 1 1 0 MRG DUF3939 PF13075.6 KPI89625.1 - 0.017 15.2 0.1 0.025 14.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) NMT PF01233.19 KPI89627.1 - 1.3e-66 223.4 0.0 2.3e-66 222.6 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 KPI89627.1 - 3.4e-62 209.7 0.0 5.9e-62 208.9 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain SNARE PF05739.19 KPI89628.1 - 2e-10 40.5 0.7 3.8e-09 36.4 0.0 2.7 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 KPI89628.1 - 3.7e-05 23.5 16.9 0.00011 22.0 16.9 1.8 1 1 0 1 1 1 1 Syntaxin DUF2935 PF11155.8 KPI89628.1 - 0.0091 16.3 1.7 2.9 8.2 1.7 2.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2935) DUF16 PF01519.16 KPI89628.1 - 0.26 11.8 11.8 2 8.9 4.1 2.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF883 PF05957.13 KPI89628.1 - 3.2 8.4 7.5 1.4 9.6 1.5 3.2 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 KPI89628.1 - 8.6 5.8 19.9 1.6e+02 1.6 19.9 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit WD40 PF00400.32 KPI89630.1 - 8.5e-18 64.4 5.2 0.03 15.2 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89630.1 - 1.5e-06 28.4 0.3 0.064 13.6 0.0 3.6 2 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Citrus_P18 PF05520.11 KPI89631.1 - 0.11 12.2 0.1 0.46 10.2 0.0 2.0 3 0 0 3 3 3 0 Citrus tristeza virus P18 protein zf-CCCH PF00642.24 KPI89632.1 - 0.0063 16.4 0.2 0.0063 16.4 0.2 2.3 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI89632.1 - 0.022 14.8 0.2 0.022 14.8 0.2 2.1 2 0 0 2 2 2 0 Zinc finger domain Torus PF16131.5 KPI89632.1 - 0.064 14.0 3.2 0.26 12.0 0.4 2.6 2 1 0 2 2 2 0 Torus domain TrbM PF07424.11 KPI89633.1 - 0.084 12.8 5.4 0.35 10.8 0.3 3.0 1 1 1 2 2 2 0 TrbM DUF515 PF04415.12 KPI89634.1 - 0.085 11.2 0.0 0.097 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Gtr1_RagA PF04670.12 KPI89635.1 - 9.3e-91 303.3 0.0 2.6e-90 301.8 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KPI89635.1 - 1.4e-06 28.5 0.0 8.7e-06 26.0 0.0 2.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI89635.1 - 1.9e-05 24.4 0.0 5.5e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Ras family Arf PF00025.21 KPI89635.1 - 0.00026 20.5 0.0 0.0012 18.4 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_7 PF12775.7 KPI89635.1 - 0.13 11.7 0.0 0.98 8.9 0.0 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region CbiG_N PF11760.8 KPI89636.1 - 0.99 9.5 5.7 0.39 10.8 2.0 2.3 2 0 0 2 2 2 0 Cobalamin synthesis G N-terminal CarboxypepD_reg PF13620.6 KPI89636.1 - 3.3 8.1 5.8 0.38 11.0 0.1 2.4 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain PhoLip_ATPase_C PF16212.5 KPI89638.1 - 1.9e-62 211.3 20.5 1.9e-62 211.3 20.5 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KPI89638.1 - 1.3e-24 85.6 4.2 1.5e-24 85.4 2.3 2.2 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KPI89638.1 - 5.4e-10 39.2 0.0 7.7e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KPI89638.1 - 1.5e-09 38.5 0.9 8e-06 26.3 0.2 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KPI89638.1 - 1.3e-08 34.6 0.0 1.3e-08 34.6 0.0 4.6 4 2 0 4 4 4 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KPI89638.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AAA PF00004.29 KPI89639.1 - 6.4e-16 59.0 0.0 1.4e-15 57.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KPI89639.1 - 0.027 14.2 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KPI89639.1 - 0.048 13.8 0.0 0.19 11.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Radical_SAM_N PF08497.10 KPI89639.1 - 0.062 12.5 1.2 0.11 11.7 1.2 1.3 1 0 0 1 1 1 0 Radical SAM N-terminal IQ PF00612.27 KPI89639.1 - 0.073 12.9 0.1 0.073 12.9 0.1 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_16 PF13191.6 KPI89639.1 - 0.092 13.1 4.9 0.41 11.0 0.0 3.4 2 1 0 3 3 3 0 AAA ATPase domain Metallophos PF00149.28 KPI89641.1 - 3.6e-25 89.7 0.0 6.4e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI89641.1 - 2.5e-05 24.6 0.0 5.1e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PIN_4 PF13638.6 KPI89642.1 - 1.1e-18 67.8 0.0 2.2e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 PIN domain Lactamase_B_2 PF12706.7 KPI89643.1 - 0.27 10.7 0.0 0.27 10.7 0.0 2.6 3 1 1 4 4 4 0 Beta-lactamase superfamily domain Ran_BP1 PF00638.18 KPI89644.1 - 1e-26 93.6 0.8 1.2e-26 93.3 0.8 1.1 1 0 0 1 1 1 1 RanBP1 domain HECT PF00632.25 KPI89645.1 - 1.5e-44 152.7 0.0 4.2e-44 151.3 0.0 1.7 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 KPI89645.1 - 5e-20 71.8 0.0 9.4e-10 38.7 0.0 2.7 2 0 0 2 2 2 2 SPRY domain EF-hand_1 PF00036.32 KPI89646.1 - 3.8e-23 79.2 0.2 3.7e-05 23.0 0.1 5.2 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KPI89646.1 - 7e-22 77.7 0.1 2.4e-09 37.5 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI89646.1 - 9.3e-21 71.9 2.2 0.00045 19.9 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KPI89646.1 - 2.3e-14 53.0 0.6 1.8e-06 27.7 0.1 4.8 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 KPI89646.1 - 1e-12 46.9 2.5 0.00021 20.6 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KPI89646.1 - 0.00015 22.0 0.2 4.1 7.8 0.0 3.4 2 2 1 3 3 3 1 EF-hand domain PAH PF02671.21 KPI89646.1 - 0.015 15.5 0.0 0.072 13.2 0.0 2.1 2 0 0 2 2 2 0 Paired amphipathic helix repeat EF-hand_10 PF14788.6 KPI89646.1 - 0.03 14.2 0.4 0.19 11.6 0.0 2.4 3 0 0 3 3 3 0 EF hand TerB PF05099.13 KPI89646.1 - 0.12 12.3 0.1 0.23 11.4 0.0 1.5 2 0 0 2 2 2 0 Tellurite resistance protein TerB Caleosin PF05042.13 KPI89646.1 - 0.18 11.7 1.2 28 4.6 0.2 3.0 2 1 1 3 3 3 0 Caleosin related protein EF-hand_7 PF13499.6 KPI89647.1 - 1.5e-14 54.1 2.8 8.6e-09 35.7 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI89647.1 - 6.4e-14 50.4 0.1 0.0029 17.0 0.0 5.2 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KPI89647.1 - 3.6e-12 45.2 3.2 0.016 15.1 0.0 5.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 KPI89647.1 - 3e-10 39.8 3.2 0.00026 20.8 0.0 3.9 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 KPI89647.1 - 5.3e-06 25.7 6.3 0.0065 15.9 0.0 4.1 5 0 0 5 5 5 2 EF hand Caleosin PF05042.13 KPI89647.1 - 0.21 11.5 0.5 2.3 8.1 0.2 2.4 1 1 2 3 3 3 0 Caleosin related protein LRR_4 PF12799.7 KPI89649.1 - 5.7e-11 42.5 3.8 6.2e-05 23.3 0.1 3.2 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI89649.1 - 1.9e-05 24.3 5.8 0.0048 16.6 1.4 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 KPI89649.1 - 0.0088 15.6 0.1 0.033 13.7 0.0 1.8 2 0 0 2 2 2 1 Leucine-rich repeat FAD-SLDH PF12318.8 KPI89649.1 - 3.6 7.7 8.0 0.23 11.5 0.9 2.4 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase RVT_N PF13655.6 KPI89650.1 - 0.049 13.9 0.2 0.087 13.1 0.2 1.3 1 0 0 1 1 1 0 N-terminal domain of reverse transcriptase Penicil_amidase PF01804.18 KPI89651.1 - 3.9e-117 393.0 0.2 1.1e-116 391.4 0.2 1.6 1 1 0 1 1 1 1 Penicillin amidase DUF3311 PF11755.8 KPI89651.1 - 1.9 8.5 7.5 0.94 9.5 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) WD40 PF00400.32 KPI89653.1 - 0.49 11.4 5.9 63 4.7 0.0 5.2 6 0 0 6 6 6 0 WD domain, G-beta repeat Lactamase_B_2 PF12706.7 KPI89654.1 - 1.4e-29 103.1 0.2 1.1e-25 90.4 0.2 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KPI89654.1 - 3.8e-08 33.4 0.0 1.1e-07 31.9 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KPI89654.1 - 0.016 15.2 0.4 0.33 10.9 0.4 2.2 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily EMP70 PF02990.16 KPI89655.1 - 1.1e-103 347.7 15.7 1.6e-103 347.2 15.7 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Sin_N PF04801.13 KPI89656.1 - 4.3e-69 233.8 0.0 9e-69 232.7 0.0 1.4 2 0 0 2 2 2 1 Sin-like protein conserved region DMPK_coil PF08826.10 KPI89657.1 - 0.028 14.5 4.0 0.044 13.9 0.3 2.8 2 1 1 3 3 3 0 DMPK coiled coil domain like SesA PF17107.5 KPI89657.1 - 0.11 12.7 0.9 0.27 11.4 0.3 2.0 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Dpy-30 PF05186.13 KPI89658.1 - 7.2e-13 48.0 0.2 1.3e-12 47.2 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif Hydin_ADK PF17213.3 KPI89658.1 - 2.5e-05 24.7 0.0 2.5e-05 24.7 0.0 3.2 3 0 0 3 3 3 1 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KPI89658.1 - 0.0065 17.0 0.0 1.9 9.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KPI89658.1 - 0.053 13.9 0.1 0.73 10.3 0.0 3.0 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 KPI89658.1 - 0.06 13.6 1.9 0.19 11.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain 6PF2K PF01591.18 KPI89658.1 - 0.13 11.5 0.0 0.28 10.4 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.6 KPI89658.1 - 0.97 9.8 5.2 0.63 10.4 0.2 2.6 2 0 0 2 2 2 0 AAA ATPase domain TPR_11 PF13414.6 KPI89659.1 - 0.082 12.6 2.3 0.16 11.7 2.3 1.5 1 0 0 1 1 1 0 TPR repeat NPV_P10 PF05531.12 KPI89659.1 - 0.21 12.1 2.0 1 9.9 0.7 2.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FadA PF09403.10 KPI89659.1 - 0.74 10.3 12.3 5.1 7.6 3.0 2.9 2 0 0 2 2 2 0 Adhesion protein FadA Occludin_ELL PF07303.13 KPI89659.1 - 1.6 9.5 9.7 1.1 10.0 3.7 2.5 2 0 0 2 2 2 0 Occludin homology domain DUF5075 PF16825.5 KPI89661.1 - 9.3e-16 58.0 0.3 1.9e-15 57.0 0.3 1.6 1 0 0 1 1 1 1 IGP family C-type lectin domain DUF4492 PF14899.6 KPI89661.1 - 0.0024 17.8 0.8 0.005 16.7 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4492) Shisa PF13908.6 KPI89661.1 - 0.017 15.4 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2553 PF10830.8 KPI89661.1 - 0.044 14.6 0.6 0.2 12.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) TMIE PF16038.5 KPI89661.1 - 0.065 13.1 2.8 0.14 12.0 2.8 1.5 1 0 0 1 1 1 0 TMIE protein Renin_r PF07850.14 KPI89661.1 - 0.16 12.5 0.4 0.43 11.2 0.4 1.7 1 0 0 1 1 1 0 Renin receptor-like protein TMEM154 PF15102.6 KPI89661.1 - 0.17 11.8 0.8 0.4 10.6 0.8 1.5 1 0 0 1 1 1 0 TMEM154 protein family TRP PF06011.12 KPI89661.1 - 0.23 10.1 2.8 0.36 9.5 2.8 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF4713 PF15831.5 KPI89661.1 - 0.26 11.8 6.3 0.58 10.7 6.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) GP41 PF00517.17 KPI89661.1 - 0.53 10.2 1.7 0.96 9.3 1.7 1.3 1 0 0 1 1 1 0 Retroviral envelope protein SUR7 PF06687.12 KPI89661.1 - 0.72 9.4 3.3 0.32 10.6 0.2 1.8 2 0 0 2 2 2 0 SUR7/PalI family Orf78 PF06024.12 KPI89661.1 - 2.4 8.5 3.7 0.91 9.9 0.2 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DUF5075 PF16825.5 KPI89662.1 - 5.9e-06 26.1 0.2 5.9e-06 26.1 0.2 1.7 2 0 0 2 2 2 1 IGP family C-type lectin domain Vps55 PF04133.14 KPI89662.1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 55 Spore_YhaL PF14147.6 KPI89662.1 - 0.12 12.1 0.6 0.23 11.2 0.6 1.4 1 0 0 1 1 1 0 Sporulation protein YhaL Pox_EPC_I2-L1 PF12575.8 KPI89662.1 - 0.26 11.5 1.1 0.63 10.3 1.1 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 SNARE PF05739.19 KPI89662.1 - 0.53 10.3 3.8 1.1 9.3 3.8 1.6 1 0 0 1 1 1 0 SNARE domain Herpes_LMP1 PF05297.11 KPI89662.1 - 1.1 8.4 4.0 0.27 10.4 0.9 1.5 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Complex1_LYR_1 PF13232.6 KPI89663.1 - 2.6e-39 133.7 2.8 4.3e-39 133.0 2.8 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 KPI89663.1 - 0.00053 20.0 0.5 0.0014 18.6 0.1 2.1 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DUF4771 PF15995.5 KPI89663.1 - 0.014 15.7 0.2 0.021 15.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) ATP_bind_1 PF03029.17 KPI89665.1 - 4.8e-61 206.6 0.1 8.2e-60 202.6 0.1 2.0 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 KPI89665.1 - 1.5e-05 25.4 0.0 3.2e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KPI89665.1 - 2.9e-05 24.1 0.0 5.6e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 KPI89665.1 - 3.2e-05 23.7 0.0 0.00081 19.1 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain GTP_EFTU PF00009.27 KPI89665.1 - 0.00012 21.7 0.2 0.0086 15.6 0.2 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KPI89665.1 - 0.00033 20.6 0.0 3.1 7.7 0.0 3.5 4 0 0 4 4 4 2 RsgA GTPase AAA_24 PF13479.6 KPI89665.1 - 0.00033 20.5 0.0 0.0006 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 KPI89665.1 - 0.00033 20.3 1.3 0.0081 15.8 1.3 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 KPI89665.1 - 0.00061 20.3 0.0 0.0045 17.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KPI89665.1 - 0.002 18.3 0.0 0.0045 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 KPI89665.1 - 0.0044 16.5 0.0 0.18 11.3 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_22 PF13401.6 KPI89665.1 - 0.0046 17.2 0.0 0.0091 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KPI89665.1 - 0.005 16.4 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 KPI89665.1 - 0.0052 16.5 1.0 0.0073 16.0 0.1 1.9 2 1 0 2 2 1 1 AAA domain NB-ARC PF00931.22 KPI89665.1 - 0.006 15.8 0.1 0.016 14.4 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain SRPRB PF09439.10 KPI89665.1 - 0.0074 15.7 0.1 1 8.8 0.0 2.2 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 KPI89665.1 - 0.0083 16.0 0.0 0.029 14.3 0.0 1.9 1 1 0 1 1 1 1 NTPase Zeta_toxin PF06414.12 KPI89665.1 - 0.0087 15.4 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin KAP_NTPase PF07693.14 KPI89665.1 - 0.0099 15.2 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain MeaB PF03308.16 KPI89665.1 - 0.012 14.6 0.4 0.25 10.3 0.0 2.7 2 2 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_19 PF13245.6 KPI89665.1 - 0.013 15.8 0.2 0.022 15.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KPI89665.1 - 0.015 15.2 0.0 0.042 13.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_31 PF13614.6 KPI89665.1 - 0.019 14.9 0.0 0.88 9.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain DLIC PF05783.11 KPI89665.1 - 0.019 13.8 0.7 0.42 9.4 0.0 2.4 2 1 0 3 3 3 0 Dynein light intermediate chain (DLIC) AAA_5 PF07728.14 KPI89665.1 - 0.028 14.4 0.0 0.084 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KPI89665.1 - 0.036 13.8 0.1 0.096 12.4 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain Roc PF08477.13 KPI89665.1 - 0.037 14.2 0.3 0.25 11.6 0.1 2.4 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI89665.1 - 0.047 13.3 0.0 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Ras family G-alpha PF00503.20 KPI89665.1 - 0.049 12.8 0.0 1 8.4 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit ATPase_2 PF01637.18 KPI89665.1 - 0.065 13.1 0.0 0.091 12.7 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.29 KPI89665.1 - 0.094 13.1 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 KPI89665.1 - 0.1 12.3 0.1 0.59 9.9 0.0 2.2 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 KPI89665.1 - 0.11 11.8 0.1 0.58 9.4 0.1 2.2 1 1 0 1 1 1 0 Septin MobB PF03205.14 KPI89665.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.6 KPI89665.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Endonuclease_NS PF01223.23 KPI89666.1 - 2.6e-15 56.9 0.0 1.4e-14 54.5 0.0 1.9 2 0 0 2 2 2 1 DNA/RNA non-specific endonuclease CoA_binding_3 PF13727.6 KPI89667.1 - 0.0024 17.9 1.3 0.003 17.6 1.3 1.1 1 0 0 1 1 1 1 CoA-binding domain SieB PF14163.6 KPI89667.1 - 0.02 14.4 0.2 0.023 14.2 0.2 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B Hanta_G1 PF01567.16 KPI89667.1 - 0.027 13.2 0.1 0.031 13.0 0.1 1.1 1 0 0 1 1 1 0 Hantavirus glycoprotein G1 HemY_N PF07219.13 KPI89667.1 - 0.062 13.5 0.4 0.083 13.1 0.4 1.2 1 0 0 1 1 1 0 HemY protein N-terminus UPF0370 PF13980.6 KPI89667.1 - 0.33 11.0 2.5 0.75 9.9 2.5 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0370) DUF3325 PF11804.8 KPI89668.1 - 0.012 15.8 1.3 0.018 15.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3325) TPPK_C PF12555.8 KPI89668.1 - 1.4 9.0 6.0 2.5 8.2 6.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal DUF872 PF05915.12 KPI89669.1 - 0.18 12.0 0.0 0.42 10.8 0.0 1.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) TPK_catalytic PF04263.16 KPI89670.1 - 3.5e-10 40.0 0.1 0.0013 18.7 0.0 2.9 2 1 1 3 3 3 2 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 KPI89670.1 - 2.3e-05 24.0 0.0 5.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain MHB PF16525.5 KPI89671.1 - 0.064 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Haemophore, haem-binding Adenylsucc_synt PF00709.21 KPI89672.1 - 4.6e-91 305.8 0.0 7.1e-91 305.2 0.0 1.3 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF3880 PF12996.7 KPI89672.1 - 0.1 12.7 0.0 0.51 10.4 0.0 2.2 2 0 0 2 2 2 0 DUF based on E. rectale Gene description (DUF3880) Tctex-1 PF03645.13 KPI89673.1 - 1.4e-21 76.6 0.1 3.6e-21 75.3 0.0 1.6 1 1 1 2 2 2 1 Tctex-1 family UPF0258 PF06789.12 KPI89673.1 - 0.019 15.1 0.1 0.022 14.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) SATase_N PF06426.14 KPI89673.1 - 0.15 12.5 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal MAM33 PF02330.16 KPI89674.1 - 7.1e-10 39.2 0.0 2.8e-09 37.3 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial glycoprotein EF-hand_1 PF00036.32 KPI89675.1 - 1.1e-14 52.7 1.6 1.8e-08 33.4 0.1 3.8 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.6 KPI89675.1 - 1.1e-13 51.4 0.1 1.8e-06 28.3 0.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KPI89675.1 - 3.6e-12 45.9 0.4 0.001 18.8 0.0 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KPI89675.1 - 5.7e-10 38.3 0.0 3e-06 26.7 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.6 KPI89675.1 - 3.3e-07 29.5 0.1 4.3e-06 26.0 0.0 2.9 2 1 1 3 3 3 1 EF hand EF-hand_9 PF14658.6 KPI89675.1 - 2.7e-06 27.6 0.0 0.079 13.3 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain Patatin PF01734.22 KPI89676.1 - 0.066 13.4 0.2 0.11 12.6 0.2 1.5 1 1 0 1 1 1 0 Patatin-like phospholipase Endonuc-BglII PF09195.11 KPI89676.1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease BglII Abhydrolase_6 PF12697.7 KPI89677.1 - 1.2e-13 52.2 4.9 2.8e-12 47.7 4.9 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KPI89677.1 - 1.2e-11 44.7 0.2 2.9e-10 40.2 0.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI89677.1 - 7e-05 22.2 0.0 0.0019 17.5 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF676 PF05057.14 KPI89677.1 - 0.02 14.4 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 KPI89677.1 - 0.025 13.8 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 KPI89677.1 - 0.046 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 PGAP1-like protein DUF155 PF02582.14 KPI89678.1 - 6.2e-39 133.9 0.0 1e-38 133.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RNA_pol_N PF01194.17 KPI89679.1 - 2.4e-25 88.6 1.5 3e-25 88.3 1.5 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit tRNA-synt_1 PF00133.22 KPI89681.1 - 9.9e-30 103.3 0.0 1.3e-12 46.8 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KPI89681.1 - 8.2e-19 67.6 0.7 3.3e-08 32.7 0.0 3.5 5 0 0 5 5 5 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KPI89681.1 - 3.3e-14 53.1 1.7 7e-14 52.0 1.7 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KPI89681.1 - 1.2e-07 31.4 0.0 3.5e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain AAA PF00004.29 KPI89682.1 - 1.2e-42 145.5 0.0 2e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI89682.1 - 6.3e-09 35.5 0.5 1.3e-08 34.5 0.5 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KPI89682.1 - 3e-06 27.1 0.1 6e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KPI89682.1 - 3.2e-06 27.4 0.0 6.2e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KPI89682.1 - 3.9e-06 26.9 0.1 1.3e-05 25.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_OB_N PF17758.1 KPI89682.1 - 2.6e-05 23.8 0.1 8.4e-05 22.1 0.0 1.9 2 0 0 2 2 1 1 Proteasomal ATPase OB N-terminal domain AAA_16 PF13191.6 KPI89682.1 - 3.3e-05 24.3 0.1 0.0032 17.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KPI89682.1 - 9e-05 22.8 0.5 0.028 14.7 0.5 2.4 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KPI89682.1 - 0.00047 19.4 0.0 0.00076 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KPI89682.1 - 0.0014 18.4 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KPI89682.1 - 0.0031 18.1 0.0 0.0064 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KPI89682.1 - 0.006 16.7 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 KPI89682.1 - 0.012 15.5 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 KPI89682.1 - 0.025 13.9 0.2 0.31 10.4 0.1 2.2 1 1 1 2 2 2 0 KaiC RNA_helicase PF00910.22 KPI89682.1 - 0.027 14.9 0.0 0.071 13.5 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_28 PF13521.6 KPI89682.1 - 0.034 14.4 0.1 0.084 13.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 KPI89682.1 - 0.035 14.1 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KPI89682.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 KPI89682.1 - 0.053 14.0 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KPI89682.1 - 0.061 13.0 0.5 0.26 11.0 0.3 2.3 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KPI89682.1 - 0.077 12.2 0.1 0.15 11.2 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 KPI89682.1 - 0.099 12.6 0.2 0.97 9.3 0.1 2.2 1 1 1 2 2 2 0 NACHT domain TIP49 PF06068.13 KPI89682.1 - 0.1 11.8 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 KPI89682.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 KPI89682.1 - 0.15 11.2 0.0 0.95 8.6 0.0 2.3 4 0 0 4 4 4 0 NB-ARC domain AAA_25 PF13481.6 KPI89682.1 - 0.21 11.2 0.8 5.2 6.6 0.3 2.5 1 1 0 2 2 2 0 AAA domain TetR_C_12 PF16914.5 KPI89684.1 - 0.056 13.6 0.1 0.82 9.8 0.1 2.6 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal FAD_binding_6 PF00970.24 KPI89685.1 - 1.2e-31 109.0 0.0 1.9e-31 108.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KPI89685.1 - 1.4e-27 96.5 0.0 6.2e-27 94.4 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KPI89685.1 - 0.0016 18.6 0.0 0.016 15.3 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 KPI89685.1 - 0.076 13.2 0.1 0.29 11.4 0.0 1.8 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain DUF870 PF05912.11 KPI89685.1 - 0.1 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) Dpy-30 PF05186.13 KPI89686.1 - 1.7e-06 27.6 0.1 3.1e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif Peptidase_S8 PF00082.22 KPI89688.1 - 1.5e-23 83.6 0.0 3e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Subtilase family Filament PF00038.21 KPI89689.1 - 0.025 14.2 0.4 0.034 13.7 0.4 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF4856 PF16148.5 KPI89689.1 - 0.14 11.1 0.2 0.21 10.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4856) SPX PF03105.19 KPI89689.1 - 0.16 11.9 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 SPX domain GrpE PF01025.19 KPI89689.1 - 0.19 11.4 1.0 0.3 10.7 1.0 1.2 1 0 0 1 1 1 0 GrpE DivIC PF04977.15 KPI89689.1 - 0.62 9.9 3.5 1.1 9.0 3.5 1.4 1 0 0 1 1 1 0 Septum formation initiator CAP59_mtransfer PF11735.8 KPI89690.1 - 6.3e-52 176.7 0.0 5.3e-51 173.6 0.0 2.1 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 DUF2567 PF10821.8 KPI89691.1 - 0.047 13.8 1.3 0.37 10.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2567) PGA2 PF07543.12 KPI89692.1 - 3.2 7.7 6.8 7.5 6.5 6.8 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Phage_C PF12025.8 KPI89693.1 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Phage protein C DUF3221 PF11518.8 KPI89693.1 - 0.11 12.9 0.1 0.33 11.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3221) A_deaminase PF00962.22 KPI89694.1 - 1.6e-82 277.5 0.0 8.9e-77 258.6 0.0 3.2 2 1 0 2 2 2 2 Adenosine/AMP deaminase AAA PF00004.29 KPI89696.1 - 6.1e-37 127.0 0.0 1.2e-36 126.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI89696.1 - 1.3e-07 31.3 0.9 2.6e-07 30.3 0.3 1.8 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 KPI89696.1 - 5.5e-06 26.7 2.2 0.026 14.8 0.1 3.4 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 KPI89696.1 - 1.2e-05 25.1 0.0 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 KPI89696.1 - 4.8e-05 23.3 0.0 0.00013 21.9 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_24 PF13479.6 KPI89696.1 - 0.00016 21.5 0.0 0.00028 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI89696.1 - 0.00055 20.4 0.1 0.0021 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 KPI89696.1 - 0.00074 18.8 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain LisH_TPL PF17814.1 KPI89696.1 - 0.001 18.6 1.2 0.0017 18.0 0.5 1.8 2 0 0 2 2 2 1 LisH-like dimerisation domain AAA_25 PF13481.6 KPI89696.1 - 0.0033 17.0 0.2 0.12 11.9 0.1 2.4 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KPI89696.1 - 0.0047 16.7 0.0 0.0095 15.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 KPI89696.1 - 0.0058 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KPI89696.1 - 0.0066 17.0 0.0 0.019 15.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KPI89696.1 - 0.0095 15.9 0.1 0.024 14.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KPI89696.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KPI89696.1 - 0.012 15.0 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 KPI89696.1 - 0.019 14.5 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 KPI89696.1 - 0.019 14.3 0.1 0.67 9.3 0.1 2.3 1 1 1 2 2 2 0 KaiC RNA_helicase PF00910.22 KPI89696.1 - 0.023 15.1 0.0 0.069 13.6 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_33 PF13671.6 KPI89696.1 - 0.048 13.8 0.0 0.098 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KPI89696.1 - 0.089 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 KPI89696.1 - 0.091 12.5 0.0 1.7 8.3 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 KPI89696.1 - 0.12 12.6 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Actin PF00022.19 KPI89697.1 - 2.5e-115 385.4 0.0 1.3e-114 383.0 0.0 1.8 1 1 0 1 1 1 1 Actin TRM PF02005.16 KPI89698.1 - 6e-97 325.2 0.0 1.9e-46 158.9 0.1 3.1 3 0 0 3 3 3 3 N2,N2-dimethylguanosine tRNA methyltransferase Glyco_transf_25 PF01755.17 KPI89699.1 - 1.9e-17 63.8 0.0 3e-16 59.9 0.0 2.0 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) Ax_dynein_light PF10211.9 KPI89700.1 - 1.5e-06 28.3 5.5 1.5e-06 28.3 5.5 2.5 2 0 0 2 2 2 1 Axonemal dynein light chain ADIP PF11559.8 KPI89700.1 - 0.00025 21.2 6.5 0.00025 21.2 6.5 3.1 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Tom5 PF10642.9 KPI89700.1 - 0.0015 18.6 1.8 1.5 8.9 1.1 3.3 2 0 0 2 2 2 2 Mitochondrial import receptor subunit or translocase Med30 PF11315.8 KPI89700.1 - 0.11 12.7 2.4 8.9 6.5 0.5 2.9 2 0 0 2 2 2 0 Mediator complex subunit 30 ZapB PF06005.12 KPI89700.1 - 0.93 10.0 12.7 0.75 10.3 4.2 3.2 2 0 0 2 2 2 0 Cell division protein ZapB Laminin_II PF06009.12 KPI89700.1 - 1.4 8.9 6.7 5.8 6.9 1.7 3.1 2 0 0 2 2 2 0 Laminin Domain II DUF948 PF06103.11 KPI89700.1 - 1.7 8.9 8.1 1.1 9.5 0.8 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KPI89700.1 - 2 8.5 10.0 1.2 9.2 1.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 KPI89700.1 - 3.4 6.4 16.9 0.97 8.2 7.7 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein GAS PF13851.6 KPI89700.1 - 5.4 6.3 18.1 0.67 9.3 4.9 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 KPI89700.1 - 5.5 7.4 17.6 14 6.1 9.1 2.7 2 1 0 2 2 2 0 Fez1 OmpH PF03938.14 KPI89700.1 - 5.7 7.3 20.0 9.9 6.5 2.1 3.5 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) CCDC-167 PF15188.6 KPI89700.1 - 8 6.9 7.5 32 5.0 0.8 3.5 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 LRR_6 PF13516.6 KPI89701.1 - 1.6e-07 30.8 1.6 0.85 9.8 0.0 3.5 3 0 0 3 3 3 3 Leucine Rich repeat LRR_4 PF12799.7 KPI89701.1 - 0.064 13.7 6.2 0.15 12.5 2.0 3.2 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI89701.1 - 0.25 12.0 2.0 11 7.0 1.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat TFIIA PF03153.13 KPI89704.1 - 0.11 12.5 46.7 0.34 10.9 28.0 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cyt-b5 PF00173.28 KPI89705.1 - 4.1e-19 68.5 1.3 5.3e-19 68.2 1.3 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ENOD93 PF03386.14 KPI89705.1 - 0.12 12.2 1.7 0.19 11.6 1.7 1.2 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein DB_JBP1 PF18526.1 KPI89706.1 - 2.7e-85 284.4 4.9 4.3e-85 283.7 4.9 1.3 1 0 0 1 1 1 1 Thymine dioxygenase JBP1 DNA-binding domain Tet_JBP PF12851.7 KPI89706.1 - 1.2e-20 74.1 0.0 1.5e-16 60.7 0.0 2.4 1 1 1 2 2 2 2 Oxygenase domain of the 2OGFeDO superfamily Methyltransf_11 PF08241.12 KPI89706.1 - 0.092 13.4 0.1 0.34 11.6 0.1 2.0 1 0 0 1 1 1 0 Methyltransferase domain Rhodanese PF00581.20 KPI89707.1 - 7.8e-16 58.5 0.0 9e-16 58.3 0.0 1.0 1 0 0 1 1 1 1 Rhodanese-like domain DUF4859 PF16151.5 KPI89707.1 - 0.072 13.0 0.0 0.097 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4859) Rhodanese PF00581.20 KPI89708.1 - 8.5e-11 42.3 0.0 1.1e-10 42.0 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Rhodanese PF00581.20 KPI89709.1 - 0.0039 17.7 0.0 0.0048 17.4 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain HTH_Tnp_IS1 PF12759.7 KPI89709.1 - 0.066 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 InsA C-terminal domain AbfS_sensor PF18225.1 KPI89709.1 - 0.13 12.2 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 Sensor histidine kinase (AbfS) sensor domain DnaJ PF00226.31 KPI89710.1 - 7e-10 38.9 0.0 1.6e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain GcrA PF07750.11 KPI89710.1 - 0.0044 17.5 0.1 0.015 15.7 0.0 2.0 2 0 0 2 2 2 1 GcrA cell cycle regulator DUF4521 PF15021.6 KPI89710.1 - 2 8.3 6.6 0.74 9.7 3.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4521) ABC_membrane PF00664.23 KPI89711.1 - 1.5e-41 142.9 12.4 2.8e-41 142.0 12.4 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KPI89711.1 - 1.4e-33 116.3 0.0 2.5e-33 115.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KPI89711.1 - 7.2e-06 25.6 1.4 0.00089 18.7 1.4 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_membrane_2 PF06472.15 KPI89711.1 - 7.3e-06 25.6 4.6 7.3e-06 25.6 4.6 1.9 3 0 0 3 3 3 1 ABC transporter transmembrane region 2 AAA_22 PF13401.6 KPI89711.1 - 0.0018 18.5 0.4 0.017 15.4 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KPI89711.1 - 0.0051 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 KPI89711.1 - 0.0089 16.4 0.5 0.032 14.6 0.5 1.9 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KPI89711.1 - 0.018 14.9 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 KPI89711.1 - 0.019 14.2 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 KPI89711.1 - 0.023 14.5 0.1 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system C1_2 PF03107.16 KPI89711.1 - 0.024 14.9 14.6 0.066 13.5 14.6 1.8 1 0 0 1 1 1 0 C1 domain AAA_23 PF13476.6 KPI89711.1 - 0.058 13.9 0.0 0.49 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KPI89711.1 - 0.06 13.1 0.4 0.42 10.3 0.4 2.3 1 1 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 KPI89711.1 - 0.069 11.9 0.4 4.2 6.0 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class ABC_membrane_3 PF13748.6 KPI89711.1 - 0.17 11.1 7.9 0.3 10.3 4.6 2.8 1 1 1 2 2 2 0 ABC transporter transmembrane region C1_1 PF00130.22 KPI89711.1 - 0.93 9.4 10.9 2.4 8.1 10.9 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Coq4 PF05019.13 KPI89712.1 - 2.5e-62 210.1 0.0 3.2e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 SinI PF08671.10 KPI89713.1 - 0.011 15.6 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 0 Anti-repressor SinI DUF572 PF04502.13 KPI89713.1 - 0.059 13.0 6.2 0.075 12.6 6.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Mnd1 PF03962.15 KPI89713.1 - 0.081 13.2 5.1 0.15 12.4 3.4 2.1 1 1 1 2 2 2 0 Mnd1 HTH domain ETC_C1_NDUFA5 PF04716.14 KPI89713.1 - 0.15 11.9 2.1 0.68 9.8 2.1 2.2 1 1 0 1 1 1 0 ETC complex I subunit conserved region DUF3813 PF12758.7 KPI89713.1 - 0.35 11.3 4.4 11 6.4 4.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3813) SET PF00856.28 KPI89714.1 - 7e-09 36.3 0.0 2.7e-07 31.2 0.0 2.9 2 2 0 2 2 2 1 SET domain DnaJ PF00226.31 KPI89715.1 - 0.00019 21.5 0.0 0.00031 20.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4006 PF13179.6 KPI89716.1 - 0.39 10.7 1.7 0.42 10.6 0.3 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF4006) F-box PF00646.33 KPI89717.1 - 0.033 14.1 0.0 0.091 12.7 0.0 1.7 1 0 0 1 1 1 0 F-box domain Caa3_CtaG PF09678.10 KPI89721.1 - 0.032 13.7 0.7 0.045 13.2 0.7 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) DUF883 PF05957.13 KPI89723.1 - 0.016 15.8 0.8 0.027 15.1 0.8 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Atg8 PF02991.16 KPI89724.1 - 2.5e-82 271.8 0.1 5e-21 74.8 0.0 4.1 4 0 0 4 4 4 4 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KPI89724.1 - 7.6e-21 74.3 0.0 5.2e-05 23.6 0.0 4.2 4 0 0 4 4 4 4 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 KPI89725.1 - 1.1e-39 134.7 0.0 1.3e-39 134.5 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KPI89725.1 - 1.9e-08 34.6 0.0 2.2e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 TAF8_C PF10406.9 KPI89725.1 - 0.25 11.9 0.7 0.53 10.9 0.3 1.7 2 0 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term BTB_2 PF02214.22 KPI89726.1 - 3.6e-13 49.7 0.0 1e-12 48.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Hairy_orange PF07527.13 KPI89726.1 - 0.065 13.4 1.1 0.38 11.0 0.1 2.5 2 0 0 2 2 2 0 Hairy Orange Pkinase PF00069.25 KPI89727.1 - 3e-20 72.7 0.0 3.6e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89727.1 - 4.9e-07 29.3 0.0 7.9e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI89727.1 - 0.0017 17.2 0.0 0.0026 16.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase SRP19 PF01922.17 KPI89728.1 - 5.8e-18 65.6 0.0 1.1e-17 64.8 0.0 1.4 1 0 0 1 1 1 1 SRP19 protein Peptidase_M41 PF01434.18 KPI89729.1 - 6.7e-41 140.2 0.1 9.8e-41 139.7 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KPI89729.1 - 3.3e-40 137.6 0.0 8.7e-40 136.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI89729.1 - 0.00011 22.6 3.6 0.041 14.3 0.1 3.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_3 PF17862.1 KPI89729.1 - 0.00015 21.5 0.0 0.00089 19.0 0.0 2.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KPI89729.1 - 0.0011 19.3 0.8 0.022 15.0 0.1 2.9 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 KPI89729.1 - 0.0059 16.4 0.0 0.022 14.5 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KPI89729.1 - 0.012 15.6 0.7 0.11 12.4 0.3 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Peptidase_M50B PF13398.6 KPI89729.1 - 0.033 13.8 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like TIP49 PF06068.13 KPI89729.1 - 0.034 13.3 0.0 0.074 12.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 KPI89729.1 - 0.037 13.8 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 KPI89729.1 - 0.056 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KPI89729.1 - 0.065 13.3 0.2 0.7 10.0 0.1 2.7 1 1 1 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 KPI89729.1 - 0.066 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KPI89729.1 - 0.069 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 KPI89729.1 - 0.11 13.0 0.1 0.31 11.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain ELMO_CED12 PF04727.13 KPI89731.1 - 4.7e-27 95.2 0.1 1e-26 94.1 0.1 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family IMPDH PF00478.25 KPI89732.1 - 1.5e-123 412.2 5.0 1.7e-123 412.0 5.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 KPI89732.1 - 5.5e-12 45.9 0.4 1.1e-05 25.8 0.1 2.8 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 KPI89732.1 - 4.7e-11 42.3 0.3 4.7e-11 42.3 0.3 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 KPI89732.1 - 4.5e-06 26.3 4.9 0.0081 15.6 2.2 2.5 2 1 0 2 2 2 2 Nitronate monooxygenase Glu_synthase PF01645.17 KPI89732.1 - 0.018 14.2 1.0 0.018 14.2 1.0 1.8 2 0 0 2 2 2 0 Conserved region in glutamate synthase NanE PF04131.14 KPI89732.1 - 0.022 14.0 0.1 0.058 12.6 0.1 1.8 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 KPI89732.1 - 0.047 13.1 0.3 2.3 7.6 0.0 2.4 1 1 1 2 2 2 0 Histidine biosynthesis protein Formyl_trans_C PF02911.18 KPI89732.1 - 0.11 12.8 0.0 4.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Formyl transferase, C-terminal domain WD40 PF00400.32 KPI89733.1 - 2.5e-10 40.8 1.6 0.0019 19.0 0.1 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89733.1 - 2.4e-08 34.1 0.0 0.00031 21.0 0.0 4.1 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KPI89733.1 - 0.027 14.4 0.0 59 3.5 0.0 3.9 4 1 0 5 5 5 0 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 KPI89733.1 - 0.096 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Carn_acyltransf PF00755.20 KPI89734.1 - 1e-144 483.4 0.0 1.4e-144 483.0 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase FKBP_C PF00254.28 KPI89735.1 - 6.8e-33 112.9 0.0 1e-31 109.1 0.0 2.4 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 KPI89735.1 - 2.2e-09 36.7 2.1 0.03 14.2 0.0 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI89735.1 - 4.4e-09 36.7 3.4 8.8e-09 35.8 1.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI89735.1 - 5.5e-09 35.5 3.3 0.042 14.0 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89735.1 - 1.2e-06 28.8 3.1 0.066 14.1 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI89735.1 - 1e-05 25.7 0.7 0.0026 18.0 0.1 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI89735.1 - 2.3e-05 24.4 0.9 0.17 12.3 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI89735.1 - 0.00018 21.5 0.0 0.023 14.8 0.0 2.6 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 KPI89735.1 - 0.00053 20.6 5.4 1.3 9.7 0.2 3.4 1 1 0 2 2 2 2 Tetratricopeptide repeat FKBP_N_2 PF18023.1 KPI89735.1 - 0.00084 19.4 0.0 0.2 11.8 0.0 2.7 2 0 0 2 2 2 1 BDBT FKBP like N-terminal TPR_9 PF13371.6 KPI89735.1 - 0.0012 19.0 0.5 0.002 18.3 0.5 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI89735.1 - 0.0017 18.2 0.1 9.6 6.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89735.1 - 0.0069 16.5 0.5 1.9 8.9 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat OSCP PF00213.18 KPI89735.1 - 0.0091 16.1 1.5 0.018 15.2 1.5 1.5 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit TPR_11 PF13414.6 KPI89735.1 - 0.01 15.5 0.9 1.1 9.0 0.0 2.9 2 1 1 3 3 3 0 TPR repeat TPR_6 PF13174.6 KPI89735.1 - 0.011 16.4 0.1 0.011 16.4 0.1 3.2 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI89735.1 - 0.13 12.5 0.1 0.56 10.5 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPT PF03151.16 KPI89737.1 - 2.1e-21 76.5 22.3 2.6e-21 76.2 22.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KPI89737.1 - 6.1e-06 26.5 14.1 6.1e-06 26.5 14.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family IF4E PF01652.18 KPI89739.1 - 9.3e-38 129.5 0.0 1.3e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Pkinase PF00069.25 KPI89740.1 - 2.1e-43 148.6 0.0 1.2e-28 100.2 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89740.1 - 6.1e-20 71.6 0.0 1.2e-15 57.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI89740.1 - 0.058 12.2 0.0 0.1 11.3 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase ACT_7 PF13840.6 KPI89742.1 - 1.4e-10 40.8 0.1 2.7e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_3 PF10000.9 KPI89742.1 - 3.8e-10 39.6 0.2 9.3e-10 38.3 0.2 1.7 1 1 0 1 1 1 1 ACT domain NAD_binding_1 PF00175.21 KPI89743.1 - 4.5e-09 36.9 0.0 7.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.20 KPI89743.1 - 1e-08 35.1 0.0 9.4e-05 22.1 0.0 2.7 2 1 1 3 3 3 2 FAD binding domain Pkinase PF00069.25 KPI89744.1 - 9.2e-66 221.9 0.0 1.1e-65 221.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89744.1 - 1e-33 116.8 0.0 1.2e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89744.1 - 4.7e-06 26.1 0.0 7.3e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI89744.1 - 0.00033 20.6 0.6 0.00086 19.3 0.6 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI89744.1 - 0.0065 15.8 0.9 0.011 15.1 0.9 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KPI89744.1 - 0.025 13.5 0.2 0.034 13.1 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain SpoIIIAC PF06686.11 KPI89744.1 - 0.04 14.1 0.3 0.088 13.0 0.3 1.6 1 0 0 1 1 1 0 Stage III sporulation protein AC/AD protein family PIH1 PF08190.12 KPI89745.1 - 1.1e-07 31.4 0.0 2.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 PIH1 N-terminal domain PIH1_CS PF18201.1 KPI89745.1 - 0.0038 17.6 0.0 0.0092 16.4 0.0 1.7 1 0 0 1 1 1 1 PIH1 CS-like domain Phage_TAC_3 PF06896.11 KPI89745.1 - 0.084 13.5 0.2 0.15 12.7 0.2 1.3 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC DUF1068 PF06364.12 KPI89745.1 - 0.14 12.0 1.8 0.35 10.7 1.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1068) LRR_4 PF12799.7 KPI89746.1 - 4.9e-62 204.8 46.1 0.00025 21.4 0.2 25.4 17 6 10 29 29 29 19 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KPI89746.1 - 1.7e-07 30.9 15.3 3.2e-05 23.5 0.3 8.1 6 4 5 12 12 12 3 Leucine-rich repeat LRR_5 PF13306.6 KPI89746.1 - 1.3e-05 25.1 2.4 1.4 8.9 0.0 5.7 6 0 0 6 6 6 1 BspA type Leucine rich repeat region (6 copies) zf-C3HC4_3 PF13920.6 KPI89746.1 - 0.0067 16.3 12.2 0.036 13.9 12.2 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI89746.1 - 4.7 7.6 20.9 0.6 10.5 14.0 3.2 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 KPI89746.1 - 5 7.2 14.0 24 5.0 14.0 2.4 1 0 0 1 1 1 0 zinc-RING finger domain LRR_4 PF12799.7 KPI89747.1 - 2.5e-27 94.5 0.0 5.8e-05 23.4 0.0 10.6 7 3 3 11 11 11 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KPI89747.1 - 0.44 11.3 6.3 2.7e+02 2.8 0.0 6.7 8 0 0 8 8 8 0 Leucine Rich Repeat BAR_3 PF16746.5 KPI89748.1 - 0.045 13.5 1.4 0.089 12.5 1.4 1.4 1 0 0 1 1 1 0 BAR domain of APPL family zf-XS PF03470.14 KPI89748.1 - 0.066 13.5 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 XS zinc finger domain Abhydrolase_1 PF00561.20 KPI89750.1 - 6.2e-10 39.1 0.0 1.4e-09 38.0 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KPI89750.1 - 5e-08 32.5 0.0 1.3e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI89750.1 - 3.3e-07 31.1 0.6 3.3e-07 31.1 0.6 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KPI89750.1 - 0.049 13.1 0.0 0.095 12.2 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Palm_thioest PF02089.15 KPI89750.1 - 0.14 12.0 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Pro_isomerase PF00160.21 KPI89751.1 - 4e-19 69.4 0.0 3.8e-18 66.2 0.0 2.1 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD UPF0220 PF05255.11 KPI89753.1 - 3.8e-18 65.6 0.5 5e-18 65.2 0.5 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) EamA PF00892.20 KPI89753.1 - 8.6e-05 22.7 3.3 0.00011 22.3 3.3 1.1 1 0 0 1 1 1 1 EamA-like transporter family DUF3267 PF11667.8 KPI89753.1 - 0.0026 18.0 0.5 0.0026 18.0 0.5 1.6 2 0 0 2 2 2 1 Putative zincin peptidase ABC2_membrane_5 PF13346.6 KPI89753.1 - 0.0046 16.5 2.4 0.006 16.2 2.4 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Cation_efflux PF01545.21 KPI89753.1 - 0.024 14.4 1.4 0.033 13.9 1.4 1.2 1 0 0 1 1 1 0 Cation efflux family DUF998 PF06197.13 KPI89753.1 - 0.12 12.0 8.5 0.22 11.1 8.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF998) Yip1 PF04893.17 KPI89753.1 - 0.32 10.7 10.0 0.11 12.2 6.4 1.8 1 1 1 2 2 2 0 Yip1 domain DUF4282 PF14110.6 KPI89753.1 - 2.7 8.8 7.9 0.78 10.5 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) MATH PF00917.26 KPI89754.1 - 3.8e-07 30.3 0.6 1.2e-06 28.7 0.6 1.9 1 0 0 1 1 1 1 MATH domain SPT6_acidic PF14632.6 KPI89754.1 - 0.012 16.2 16.2 0.012 16.2 16.2 5.2 3 1 0 4 4 4 0 Acidic N-terminal SPT6 CorA PF01544.18 KPI89754.1 - 2.6 7.3 14.3 6.6 5.9 14.3 1.7 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Cyclin_N PF00134.23 KPI89757.1 - 1.3e-24 86.3 0.6 4.2e-24 84.7 0.2 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain TERF2_RBM PF16772.5 KPI89757.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 Telomeric repeat-binding factor 2 Rap1-binding motif FoP_duplication PF13865.6 KPI89758.1 - 9.9e-06 26.0 10.1 9.9e-06 26.0 10.1 5.2 1 1 1 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 SAPS PF04499.15 KPI89758.1 - 0.26 10.0 7.0 0.31 9.8 7.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Menin PF05053.13 KPI89758.1 - 3 6.1 11.2 3.9 5.7 11.2 1.2 1 0 0 1 1 1 0 Menin DUF3622 PF12286.8 KPI89759.1 - 0.059 13.7 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3622) WD40_3 PF15911.5 KPI89760.1 - 0.054 13.5 0.0 0.48 10.5 0.0 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat LRR_1 PF00560.33 KPI89760.1 - 0.12 13.0 0.1 82 4.4 0.1 3.6 2 0 0 2 2 2 0 Leucine Rich Repeat WD40 PF00400.32 KPI89760.1 - 0.19 12.7 5.4 2.1 9.3 0.1 4.8 4 0 0 4 4 4 0 WD domain, G-beta repeat LRR_4 PF12799.7 KPI89761.1 - 3.7e-12 46.3 5.2 0.032 14.7 0.0 5.8 3 1 4 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI89761.1 - 3.4e-11 42.7 3.4 0.055 13.2 0.1 5.5 5 1 0 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 KPI89761.1 - 2.2 9.2 10.2 1.2e+02 3.9 0.0 5.8 5 1 0 5 5 5 0 Leucine Rich Repeat FAD-oxidase_C PF02913.19 KPI89762.1 - 3e-50 171.2 0.0 1e-49 169.5 0.0 1.8 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KPI89762.1 - 2.3e-36 124.6 0.0 3.9e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain tRNA-synt_2 PF00152.20 KPI89763.1 - 2.6e-79 266.6 0.0 3.7e-79 266.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KPI89763.1 - 6e-11 42.2 0.1 1.1e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KPI89763.1 - 9e-09 35.2 0.2 0.00026 20.5 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Yip1 PF04893.17 KPI89764.1 - 2.5e-11 43.6 9.3 3.9e-11 43.0 9.3 1.3 1 0 0 1 1 1 1 Yip1 domain LRR_6 PF13516.6 KPI89765.1 - 2.4e-38 126.9 12.3 5.7e-05 22.9 0.1 9.2 9 0 0 9 9 9 9 Leucine Rich repeat LRR_4 PF12799.7 KPI89765.1 - 5.1e-12 45.8 14.6 0.0015 18.9 0.2 5.3 3 3 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI89765.1 - 1.1e-06 28.3 13.1 0.12 12.1 1.7 6.2 4 2 1 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 KPI89765.1 - 9e-06 25.6 5.9 17 6.5 0.0 7.2 7 1 0 7 7 7 3 Leucine Rich Repeat Rubis-subs-bind PF09273.11 KPI89766.1 - 4.5e-12 46.8 0.0 1.7e-11 44.9 0.0 2.0 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 KPI89766.1 - 0.056 13.8 0.0 0.094 13.1 0.0 1.5 1 0 0 1 1 1 0 SET domain NAD_binding_2 PF03446.15 KPI89768.1 - 1.2e-51 175.0 0.5 2.1e-51 174.2 0.5 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KPI89768.1 - 3.5e-34 117.7 1.0 3.5e-34 117.7 1.0 1.6 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 KPI89768.1 - 1.2e-05 24.8 0.6 2.2e-05 23.9 0.0 1.8 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KPI89768.1 - 1.5e-05 25.5 0.4 6.4e-05 23.5 0.0 2.3 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 KPI89768.1 - 5.2e-05 23.3 0.1 0.00014 22.0 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 KPI89768.1 - 0.00039 20.4 0.3 0.0013 18.7 0.1 2.1 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 KPI89768.1 - 0.0086 15.7 0.1 0.66 9.5 0.0 2.3 1 1 1 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.12 KPI89768.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 KPI89768.1 - 0.021 14.5 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MGAT2 PF05060.14 KPI89768.1 - 0.049 12.7 0.1 0.07 12.2 0.1 1.1 1 0 0 1 1 1 0 N-acetylglucosaminyltransferase II (MGAT2) NAD_Gly3P_dh_N PF01210.23 KPI89768.1 - 0.054 13.5 0.8 0.54 10.2 0.0 2.7 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sacchrp_dh_NADP PF03435.18 KPI89768.1 - 0.089 13.1 0.2 0.28 11.4 0.0 2.1 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain PNK3P PF08645.11 KPI89769.1 - 2.2e-43 147.7 0.0 7.9e-43 146.0 0.0 1.9 2 1 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 KPI89769.1 - 5.8e-13 49.2 0.0 9.4e-11 42.0 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI89769.1 - 0.01 16.2 0.0 0.62 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Put_Phosphatase PF06888.12 KPI89769.1 - 0.039 13.3 0.2 0.66 9.3 0.0 2.7 3 0 0 3 3 3 0 Putative Phosphatase Lipoprotein_20 PF13942.6 KPI89769.1 - 0.13 12.2 0.4 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 YfhG lipoprotein Zeta_toxin PF06414.12 KPI89769.1 - 0.14 11.4 0.0 1 8.6 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin PDH_E1_M PF17831.1 KPI89769.1 - 0.17 11.4 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Pyruvate dehydrogenase E1 component middle domain RrnaAD PF00398.20 KPI89772.1 - 3.6e-61 206.6 0.0 5.1e-61 206.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KPI89772.1 - 8.6e-08 32.8 0.0 1.6e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI89772.1 - 2.9e-05 24.6 0.0 5.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI89772.1 - 0.002 18.8 0.0 0.0041 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI89772.1 - 0.0023 17.8 0.0 0.004 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KPI89772.1 - 0.017 14.9 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 KPI89772.1 - 0.024 13.9 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain DREV PF05219.12 KPI89772.1 - 0.037 13.1 0.0 0.07 12.2 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_28 PF02636.17 KPI89772.1 - 0.062 12.9 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 KPI89772.1 - 0.067 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 KPI89772.1 - 0.12 11.7 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 KPI89772.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KPI89772.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain zf-RanBP PF00641.18 KPI89774.1 - 5e-06 25.7 2.7 1.2e-05 24.5 2.7 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others VHS PF00790.19 KPI89774.1 - 0.0028 17.5 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 VHS domain Mito_carr PF00153.27 KPI89775.1 - 2.6e-12 46.5 0.1 5.4e-08 32.7 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein RNase_T PF00929.24 KPI89777.1 - 9.8e-17 62.0 0.0 1.9e-16 61.0 0.0 1.6 1 0 0 1 1 1 1 Exonuclease UCH_1 PF13423.6 KPI89777.1 - 2.6e-13 50.3 0.0 7.6e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 KPI89777.1 - 2.1e-05 24.2 0.0 4.7e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PCuAC PF04314.13 KPI89777.1 - 0.087 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Copper chaperone PCu(A)C zf-C2H2_4 PF13894.6 KPI89778.1 - 2.1e-15 56.1 50.2 0.0076 17.0 0.5 9.0 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KPI89778.1 - 1.5e-10 41.1 20.2 0.017 15.4 0.1 6.7 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KPI89778.1 - 1.8e-07 31.3 9.3 6.3e-05 23.2 0.1 5.7 6 0 0 6 6 6 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KPI89778.1 - 9.7e-07 29.0 42.1 0.028 14.7 4.2 7.4 7 1 0 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 KPI89778.1 - 0.00014 22.1 51.8 0.031 14.7 0.2 8.9 9 0 0 9 9 8 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KPI89778.1 - 0.013 15.9 0.7 0.013 15.9 0.7 7.4 7 2 0 7 7 6 0 Zinc-finger double domain Zf_RING PF16744.5 KPI89778.1 - 0.015 15.4 11.3 0.73 10.0 0.3 4.8 5 0 0 5 5 4 0 KIAA1045 RING finger zinc_ribbon_9 PF14369.6 KPI89778.1 - 0.026 14.8 0.1 0.026 14.8 0.1 5.1 5 0 0 5 5 4 0 zinc-ribbon dCMP_cyt_deam_1 PF00383.23 KPI89778.1 - 0.27 11.1 2.9 18 5.2 0.6 2.8 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region HNH PF01844.23 KPI89778.1 - 0.38 11.0 9.1 17 5.7 0.5 4.3 3 1 0 3 3 3 0 HNH endonuclease TRAF6_Z2 PF18048.1 KPI89778.1 - 0.96 9.6 6.5 24 5.1 0.1 4.3 4 0 0 4 4 4 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_9 PF16293.5 KPI89778.1 - 1.5 8.8 10.3 28 4.7 1.7 4.4 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) FOXP-CC PF16159.5 KPI89778.1 - 1.5 9.5 16.7 37 5.0 0.1 5.6 5 0 0 5 5 5 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 KPI89778.1 - 1.6 8.9 31.5 0.18 11.8 0.3 6.5 6 0 0 6 6 6 0 C2H2-type zinc finger OrfB_Zn_ribbon PF07282.11 KPI89778.1 - 1.8 8.5 4.5 11 6.0 0.0 3.9 4 0 0 4 4 4 0 Putative transposase DNA-binding domain Peptidase_C54 PF03416.19 KPI89779.1 - 9e-46 156.5 0.3 2.4e-45 155.1 0.3 1.6 1 1 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 KPI89779.1 - 0.0065 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C78 FlpD PF02662.16 KPI89779.1 - 0.08 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit COP23 PF14218.6 KPI89779.1 - 0.1 12.3 0.1 0.35 10.6 0.1 1.8 2 0 0 2 2 2 0 Circadian oscillating protein COP23 LIM PF00412.22 KPI89780.1 - 2.7e-05 24.3 9.0 2.7e-05 24.3 9.0 2.3 2 1 0 2 2 2 1 LIM domain NCD3G PF07562.14 KPI89780.1 - 0.5 10.4 6.2 9.4 6.3 0.2 2.4 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR TssO PF17561.2 KPI89783.1 - 0.048 13.8 0.8 0.12 12.5 0.8 1.7 1 0 0 1 1 1 0 Type VI secretion system, TssO Bacillus_HBL PF05791.11 KPI89783.1 - 1.7 8.5 7.6 0.16 11.8 0.9 2.3 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF2207 PF09972.9 KPI89784.1 - 0.057 12.2 0.0 0.064 12.0 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PET117 PF15786.5 KPI89784.1 - 0.11 12.8 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial DcpS_C PF11969.8 KPI89785.1 - 7.3e-21 74.8 0.1 1.3e-20 74.0 0.1 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 KPI89785.1 - 7.2e-12 45.9 0.0 1.9e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 HIT domain zf-C2HE PF16278.5 KPI89785.1 - 2e-06 28.1 0.0 5e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 KPI89785.1 - 0.085 13.2 0.4 0.18 12.2 0.4 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) PHO4 PF01384.20 KPI89786.1 - 4.7e-85 285.6 17.8 5.8e-85 285.3 17.8 1.1 1 0 0 1 1 1 1 Phosphate transporter family DUF436 PF04260.12 KPI89786.1 - 0.11 12.1 0.1 0.34 10.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF436) CAF1C_H4-bd PF12265.8 KPI89786.1 - 0.11 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex Radial_spoke PF04712.12 KPI89787.1 - 9e-121 404.2 0.0 1.2e-120 403.8 0.0 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein RCDG1 PF15725.5 KPI89787.1 - 0.012 16.0 3.0 0.012 16.0 3.0 3.8 5 1 0 5 5 5 0 Renal cancer differentiation gene 1 protein RRM_1 PF00076.22 KPI89789.1 - 4.1e-23 81.0 0.0 3.4e-14 52.4 0.0 3.9 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KPI89789.1 - 0.00055 19.8 0.0 1.4 8.9 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif SPT6_acidic PF14632.6 KPI89789.1 - 2.7 8.6 13.5 5.3 7.7 2.1 2.7 2 0 0 2 2 2 0 Acidic N-terminal SPT6 PBP1_TM PF14812.6 KPI89789.1 - 5.5 7.4 21.2 2.3 8.7 4.2 3.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RHD3 PF05879.12 KPI89790.1 - 0.12 10.6 0.0 0.14 10.3 0.0 1.1 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) Baseplate_J PF04865.14 KPI89791.1 - 0.0012 18.0 0.1 0.0024 17.1 0.1 1.4 1 0 0 1 1 1 1 Baseplate J-like protein CLAMP PF14769.6 KPI89791.1 - 0.13 12.7 0.0 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 Itfg2 PF15907.5 KPI89792.1 - 7.9e-05 21.9 0.1 0.00022 20.4 0.1 1.6 2 0 0 2 2 2 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 KPI89792.1 - 0.00091 19.2 0.0 0.23 11.5 0.0 2.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region YdfA_immunity PF12127.8 KPI89792.1 - 0.0012 18.0 1.4 0.0021 17.2 1.4 1.3 1 0 0 1 1 1 1 SigmaW regulon antibacterial BBS2_C PF14782.6 KPI89792.1 - 0.004 16.0 0.0 1.9 7.2 0.0 2.4 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, C-terminal SIMPL PF04402.14 KPI89792.1 - 0.024 15.1 0.7 0.061 13.8 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF541) LPD38 PF18857.1 KPI89792.1 - 0.054 13.6 0.0 0.099 12.8 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 38 VCBS PF13517.6 KPI89792.1 - 0.059 14.0 0.1 0.19 12.4 0.1 1.9 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KPI89792.1 - 0.61 10.3 2.3 1.5 9.0 2.3 1.7 1 0 0 1 1 1 0 FG-GAP repeat EF_TS PF00889.19 KPI89793.1 - 4.9e-15 55.7 0.0 1.9e-14 53.8 0.0 1.7 1 1 1 2 2 2 1 Elongation factor TS DUF5641 PF18701.1 KPI89794.1 - 0.098 12.8 0.2 0.19 11.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5641) Presenilin PF01080.17 KPI89794.1 - 1 8.0 2.7 1.4 7.6 2.7 1.1 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 KPI89795.1 - 7.8e-19 67.7 6.7 0.0062 17.4 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat DAGK_cat PF00781.24 KPI89795.1 - 0.12 12.0 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Ndc1_Nup PF09531.10 KPI89796.1 - 8.7 4.9 7.4 9.8 4.7 7.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mpp10 PF04006.12 KPI89797.1 - 1.7e-64 218.4 51.7 1.5e-62 211.9 51.7 2.6 1 1 0 1 1 1 1 Mpp10 protein HSP90 PF00183.18 KPI89798.1 - 2.7e-168 561.1 7.3 3.9e-168 560.6 7.3 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 KPI89798.1 - 2.8e-09 36.9 0.0 6e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KPI89798.1 - 8.3e-08 32.7 0.0 1.6e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MFS_1 PF07690.16 KPI89799.1 - 0.049 12.5 0.0 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily U-box PF04564.15 KPI89800.1 - 5e-13 49.0 0.0 4.3e-12 46.0 0.0 2.6 3 0 0 3 3 3 1 U-box domain zf-Nse PF11789.8 KPI89800.1 - 0.0001 22.0 0.0 0.00026 20.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 KPI89800.1 - 0.048 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Retinin_C PF04527.12 KPI89800.1 - 0.48 10.7 2.2 26 5.2 0.2 2.9 3 0 0 3 3 3 0 Drosophila Retinin like protein CAP_N PF01213.19 KPI89801.1 - 1 8.8 5.3 0.49 9.8 3.3 1.4 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) N terminal SPX PF03105.19 KPI89802.1 - 0.8 9.6 3.7 1.4 8.8 0.3 2.7 3 0 0 3 3 3 0 SPX domain Matrilin_ccoil PF10393.9 KPI89803.1 - 0.078 12.8 0.4 0.15 11.9 0.4 1.5 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF5549 PF17703.1 KPI89804.1 - 0.47 10.1 9.7 0.13 11.9 3.1 2.8 2 1 0 2 2 2 0 Family of unknown function (DUF5549) Peptidase_C1 PF00112.23 KPI89806.1 - 1.9e-59 201.4 8.1 2.3e-59 201.1 8.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 KPI89806.1 - 0.00014 21.6 0.0 0.00028 20.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 KPI89806.1 - 0.00036 19.4 2.3 0.0033 16.3 0.4 2.0 2 0 0 2 2 2 2 Peptidase C1-like family Nop14 PF04147.12 KPI89807.1 - 0.71 8.0 9.2 0.9 7.7 9.2 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KPI89807.1 - 5.1 6.4 12.8 7.5 5.9 12.8 1.2 1 0 0 1 1 1 0 SDA1 HMG_box PF00505.19 KPI89809.1 - 1.9e-31 108.2 8.4 4.6e-20 71.8 0.3 3.3 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KPI89809.1 - 2.6e-23 82.4 20.9 7e-14 52.2 0.5 3.3 3 1 1 4 4 4 2 HMG-box domain DEK_C PF08766.11 KPI89809.1 - 3e-05 23.8 0.1 6.8e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain Protamine_like PF06382.11 KPI89809.1 - 0.00023 21.4 12.6 0.0004 20.6 0.7 2.2 1 1 1 2 2 2 1 Protamine and protamine like HMG_box_5 PF14887.6 KPI89809.1 - 0.00056 19.8 1.5 0.00056 19.8 1.5 3.4 3 1 0 3 3 3 2 HMG (high mobility group) box 5 YABBY PF04690.13 KPI89809.1 - 0.002 18.7 6.2 0.002 18.7 6.2 2.2 1 1 1 2 2 2 1 YABBY protein DUF2582 PF10771.9 KPI89809.1 - 0.049 13.8 0.2 9.1 6.5 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix domain (DUF2582) TPR_MLP1_2 PF07926.12 KPI89809.1 - 6.3 6.9 15.1 0.22 11.6 8.0 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein RRM_1 PF00076.22 KPI89811.1 - 2.6e-06 27.2 0.0 3.8e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Amidohydro_1 PF01979.20 KPI89812.1 - 1.6e-54 185.5 0.0 2.7e-54 184.8 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KPI89812.1 - 9.3e-07 28.7 0.0 0.00086 18.9 0.0 2.5 1 1 0 2 2 2 2 Amidohydrolase family Far-17a_AIG1 PF04750.14 KPI89812.1 - 0.13 11.6 0.1 0.22 10.8 0.1 1.3 1 0 0 1 1 1 0 FAR-17a/AIG1-like protein Cyt-b5 PF00173.28 KPI89813.1 - 3.3e-09 36.8 0.0 5.8e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4082 PF13313.6 KPI89813.1 - 0.047 13.7 1.1 0.07 13.2 0.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4082) Cyt-b5 PF00173.28 KPI89814.1 - 1.1e-12 47.9 0.0 2e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Arf PF00025.21 KPI89816.1 - 5.3e-65 218.1 0.0 6e-65 218.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI89816.1 - 7.4e-15 55.2 0.0 1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI89816.1 - 1.3e-14 54.1 0.0 1.5e-14 53.9 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KPI89816.1 - 2.4e-14 53.2 0.0 2.8e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KPI89816.1 - 7.1e-12 45.2 0.2 1.1e-08 34.6 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KPI89816.1 - 6.1e-11 42.1 0.0 7.1e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI89816.1 - 2e-08 34.3 0.0 2.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI89816.1 - 0.00024 20.7 0.0 0.00069 19.2 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 KPI89816.1 - 0.0031 16.9 0.0 0.005 16.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein cobW PF02492.19 KPI89816.1 - 0.0035 16.9 0.0 0.048 13.3 0.0 2.0 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KPI89816.1 - 0.015 15.2 0.0 2.7 7.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 KPI89816.1 - 0.03 14.7 0.4 0.49 10.8 0.0 1.9 1 1 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 KPI89816.1 - 0.12 11.3 0.0 0.48 9.4 0.0 1.9 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PhyH PF05721.13 KPI89817.1 - 7.7e-05 23.0 0.0 0.00019 21.7 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) C1_1 PF00130.22 KPI89817.1 - 7.7e-05 22.5 8.5 7.7e-05 22.5 8.5 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 KPI89817.1 - 0.19 11.6 15.4 0.47 10.4 15.4 1.7 1 0 0 1 1 1 0 PHD-finger adh_short PF00106.25 KPI89818.1 - 1.2e-32 113.0 0.5 6.6e-27 94.2 0.4 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KPI89818.1 - 1e-25 90.7 0.1 7.6e-20 71.5 0.4 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KPI89818.1 - 1.5e-06 28.3 0.1 3.1e-06 27.2 0.1 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 KPI89818.1 - 1.4e-05 24.7 0.2 0.00011 21.7 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KPI89818.1 - 0.0036 16.7 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KPI89818.1 - 0.028 13.6 0.0 0.035 13.3 0.0 1.4 1 1 0 1 1 1 0 Male sterility protein TGT_C1 PF14809.6 KPI89818.1 - 0.16 12.3 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 C1 domain of tRNA-guanine transglycosylase dimerisation SLC35F PF06027.12 KPI89819.1 - 6.6e-61 206.4 26.0 1.4e-44 152.8 6.5 2.0 2 0 0 2 2 2 2 Solute carrier family 35 CRT-like PF08627.10 KPI89819.1 - 6e-11 41.9 5.2 6e-11 41.9 5.2 1.6 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 KPI89819.1 - 1.3e-07 31.8 38.5 5.2e-05 23.4 15.4 3.0 3 0 0 3 3 3 2 EamA-like transporter family Claudin_2 PF13903.6 KPI89819.1 - 0.0081 15.9 0.0 0.0081 15.9 0.0 2.6 1 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction IPPT PF01715.17 KPI89820.1 - 2.3e-18 66.8 0.5 3.1e-18 66.4 0.5 1.1 1 0 0 1 1 1 1 IPP transferase zf-met PF12874.7 KPI89820.1 - 0.0085 16.5 1.4 0.017 15.5 1.4 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF3449 PF11931.8 KPI89820.1 - 0.044 13.6 0.8 0.12 12.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Peptidase_A22B PF04258.13 KPI89821.1 - 8.5e-60 202.7 15.1 2.1e-55 188.3 9.4 2.1 1 1 1 2 2 2 2 Signal peptide peptidase SPP PF06550.11 KPI89821.1 - 0.015 14.8 15.3 0.085 12.3 15.2 2.1 1 1 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease DUF2768 PF10966.8 KPI89821.1 - 0.06 13.8 6.2 0.17 12.3 0.8 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2768) LETM1 PF07766.13 KPI89822.1 - 3.2e-62 210.3 0.0 3.9e-61 206.7 0.0 2.1 2 0 0 2 2 2 1 LETM1-like protein DUF3562 PF12085.8 KPI89822.1 - 0.013 15.1 0.4 0.31 10.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3562) ABC_tran PF00005.27 KPI89823.1 - 0.22 12.1 0.0 0.36 11.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter FGE-sulfatase PF03781.16 KPI89824.1 - 5.1e-24 85.2 1.0 1.4e-23 83.8 1.0 1.8 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_25 PF13649.6 KPI89824.1 - 8.9e-07 29.5 0.1 6.6e-05 23.5 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain DinB_2 PF12867.7 KPI89824.1 - 1.9e-06 28.4 0.0 4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 DinB superfamily Methyltransf_31 PF13847.6 KPI89824.1 - 5.8e-05 22.9 0.0 0.0079 16.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI89824.1 - 0.0028 18.3 0.0 0.019 15.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI89824.1 - 0.0085 15.9 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI89824.1 - 0.046 14.5 0.0 0.22 12.3 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain DUF4298 PF14131.6 KPI89825.1 - 0.018 15.0 0.1 0.062 13.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Kinesin PF00225.23 KPI89827.1 - 3.6e-83 279.3 0.0 3.6e-83 279.3 0.0 3.5 4 0 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 KPI89827.1 - 2.3e-15 56.8 0.0 3.3e-14 53.1 0.0 3.1 2 0 0 2 2 2 1 Microtubule binding bZIP_1 PF00170.21 KPI89830.1 - 0.00053 20.0 0.4 0.00053 20.0 0.4 4.9 6 0 0 6 6 5 1 bZIP transcription factor Spectrin PF00435.21 KPI89830.1 - 0.0014 19.1 16.7 0.017 15.6 5.2 3.4 3 0 0 3 3 3 2 Spectrin repeat HALZ PF02183.18 KPI89830.1 - 0.0048 17.1 0.9 0.0048 17.1 0.9 3.1 4 0 0 4 4 3 1 Homeobox associated leucine zipper TMF_TATA_bd PF12325.8 KPI89830.1 - 0.0049 17.1 1.7 0.0049 17.1 1.7 4.3 4 1 1 5 5 5 2 TATA element modulatory factor 1 TATA binding LcrV PF04792.12 KPI89830.1 - 0.034 13.4 0.6 0.073 12.3 0.1 1.7 2 0 0 2 2 2 0 V antigen (LcrV) protein Z1 PF10593.9 KPI89830.1 - 0.073 12.6 1.7 13 5.2 0.0 2.7 1 1 1 2 2 2 0 Z1 domain Mit_KHE1 PF10173.9 KPI89830.1 - 0.13 12.4 2.6 0.18 11.9 1.7 1.6 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF465 PF04325.13 KPI89830.1 - 0.33 11.0 4.7 6.1 7.0 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF465) Transcrip_reg PF01709.20 KPI89830.1 - 0.68 9.3 8.3 5.9 6.2 8.3 2.2 1 1 0 1 1 1 0 Transcriptional regulator ZapB PF06005.12 KPI89830.1 - 0.71 10.4 31.0 0.18 12.3 9.7 5.1 3 2 0 3 3 3 0 Cell division protein ZapB Fmp27_WPPW PF10359.9 KPI89830.1 - 0.82 8.5 5.3 1.2 7.9 2.7 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain BLOC1_2 PF10046.9 KPI89830.1 - 0.88 9.9 14.7 2.8 8.3 0.1 5.3 5 1 1 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cauli_DNA-bind PF03310.13 KPI89830.1 - 1.2 9.3 4.9 0.61 10.2 1.9 2.2 2 0 0 2 2 1 0 Caulimovirus DNA-binding protein Acetyltransf_11 PF13720.6 KPI89830.1 - 1.2 9.6 7.5 9.2 6.8 0.0 4.0 3 1 1 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF5082 PF16888.5 KPI89830.1 - 2.1 8.6 12.3 4.5 7.6 3.9 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) TSC22 PF01166.18 KPI89830.1 - 4.2 7.7 16.0 0.66 10.3 0.1 4.8 5 0 0 5 5 5 0 TSC-22/dip/bun family DUF4988 PF16378.5 KPI89830.1 - 4.6 6.9 5.4 10 5.8 0.3 3.5 3 1 1 4 4 4 0 Domain of unknown function Baculo_PEP_C PF04513.12 KPI89830.1 - 5.6 7.0 19.9 0.15 12.1 3.8 4.2 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 KPI89830.1 - 9.6 6.4 19.9 0.32 11.2 2.3 4.4 3 2 1 4 4 4 0 Fibrinogen alpha/beta chain family MbeB_N PF04837.12 KPI89830.1 - 9.8 6.6 10.0 50 4.3 0.1 3.7 4 0 0 4 4 4 0 MbeB-like, N-term conserved region ADH_zinc_N_2 PF13602.6 KPI89831.1 - 6.1e-16 59.7 0.1 1.5e-15 58.4 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI89831.1 - 3.2e-12 46.3 0.1 6.2e-11 42.2 0.0 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI89831.1 - 1.6e-11 44.3 0.1 5.6e-11 42.5 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KPI89833.1 - 1.6e-16 61.6 0.0 3.9e-16 60.3 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KPI89833.1 - 8.6e-12 44.9 0.5 1.1e-10 41.3 0.1 2.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KPI89833.1 - 1.4e-09 38.0 0.0 5e-09 36.2 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase SseB PF07179.12 KPI89834.1 - 0.0021 18.3 0.0 1.3 9.3 0.0 2.5 2 0 0 2 2 2 2 SseB protein N-terminal domain MAJIN PF15077.6 KPI89834.1 - 0.22 11.3 1.7 0.69 9.7 1.7 1.8 1 0 0 1 1 1 0 Membrane-anchored junction protein Presenilin PF01080.17 KPI89835.1 - 2.8 6.6 8.2 2.9 6.6 8.2 1.2 1 0 0 1 1 1 0 Presenilin cNMP_binding PF00027.29 KPI89836.1 - 6.1e-16 58.3 0.0 3.2e-06 27.1 0.0 5.1 5 0 0 5 5 5 3 Cyclic nucleotide-binding domain GAGE PF05831.11 KPI89836.1 - 0.49 11.0 14.9 2 9.0 2.2 3.0 2 0 0 2 2 2 0 GAGE protein Ku PF02735.16 KPI89837.1 - 9.9e-27 94.0 0.0 1.7e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 KPI89837.1 - 1.7e-13 50.8 0.0 9.6e-10 38.6 0.0 2.3 2 0 0 2 2 2 2 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 KPI89837.1 - 0.0098 16.6 0.0 0.064 14.0 0.0 2.2 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm HeH PF12949.7 KPI89837.1 - 0.12 12.1 0.2 0.24 11.1 0.2 1.5 1 0 0 1 1 1 0 HeH/LEM domain Diphthamide_syn PF01866.17 KPI89839.1 - 6.1e-45 154.0 1.1 2.6e-23 82.9 0.0 3.1 2 1 0 2 2 2 2 Putative diphthamide synthesis protein CobU PF02283.16 KPI89839.1 - 0.012 15.2 0.8 0.12 11.9 0.0 2.5 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase SecA_DEAD PF07517.14 KPI89839.1 - 0.089 12.1 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 SecA DEAD-like domain zf-MYND PF01753.18 KPI89840.1 - 2.5e-12 46.7 43.1 9.6e-07 28.8 14.8 3.9 4 0 0 4 4 4 2 MYND finger DUF3420 PF11900.8 KPI89842.1 - 0.024 14.8 2.3 2.1 8.5 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3420) SUZ-C PF12901.7 KPI89842.1 - 0.028 14.4 1.4 8.5 6.5 0.0 4.0 4 0 0 4 4 4 0 SUZ-C motif DUF2207 PF09972.9 KPI89842.1 - 0.044 12.6 5.5 0.073 11.8 5.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Glyco_hydro_25 PF01183.20 KPI89842.1 - 0.95 9.6 4.3 2.4 8.3 0.0 3.0 2 1 0 2 2 2 0 Glycosyl hydrolases family 25 RILP PF11461.8 KPI89844.1 - 0.013 15.7 0.1 0.048 13.9 0.1 2.0 1 0 0 1 1 1 0 Rab interacting lysosomal protein Oxidored_q2 PF00420.24 KPI89845.1 - 0.033 13.8 0.1 0.033 13.8 0.1 2.3 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Arc_PepC_II PF06847.11 KPI89845.1 - 0.18 12.4 0.0 0.32 11.5 0.0 1.5 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II Mucin PF01456.17 KPI89846.1 - 0.023 14.7 8.2 0.07 13.1 8.2 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein Glycoprotein PF03409.15 KPI89846.1 - 0.052 12.4 1.8 0.082 11.7 1.8 1.2 1 0 0 1 1 1 0 Transmembrane glycoprotein Rad51 PF08423.11 KPI89848.1 - 3.7e-29 101.8 0.0 6.7e-20 71.4 0.1 3.5 3 1 0 3 3 3 3 Rad51 AAA_25 PF13481.6 KPI89848.1 - 9.6e-11 41.6 0.2 3.7e-10 39.7 0.2 2.0 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 KPI89848.1 - 4.8e-05 22.8 0.0 7.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 KaiC RecA PF00154.21 KPI89848.1 - 0.00041 19.9 0.0 0.0007 19.1 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_16 PF13191.6 KPI89848.1 - 0.0026 18.1 0.2 0.0084 16.5 0.2 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KPI89848.1 - 0.089 13.0 0.5 0.3 11.2 0.5 2.0 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 KPI89848.1 - 0.13 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KPI89848.1 - 0.15 12.0 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 KPI89848.1 - 0.17 12.4 0.0 0.37 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Radial_spoke PF04712.12 KPI89849.1 - 4.9e-08 32.4 0.0 9.6e-08 31.4 0.0 1.4 2 0 0 2 2 2 1 Radial spokehead-like protein UDPGP PF01704.18 KPI89851.1 - 3.5e-25 88.5 0.0 1.2e-23 83.5 0.0 2.2 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 KPI89851.1 - 0.019 15.4 0.3 0.11 12.9 0.0 2.3 2 0 0 2 2 2 0 MobA-like NTP transferase domain NUC173 PF08161.12 KPI89852.1 - 2.4e-15 56.7 2.6 4.4e-14 52.6 0.4 3.3 2 1 0 2 2 2 1 NUC173 domain DUF4662 PF15578.6 KPI89852.1 - 0.1 12.3 1.2 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4662) DCB PF16213.5 KPI89852.1 - 0.41 10.3 6.7 0.15 11.7 0.1 3.1 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 Peptidase_M32 PF02074.15 KPI89853.1 - 1.3e-83 281.5 0.0 1.5e-83 281.2 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Iso_dh PF00180.20 KPI89854.1 - 2.7e-108 362.2 0.0 3.2e-108 362.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.12 KPI89854.1 - 0.011 15.1 0.1 0.024 14.1 0.1 1.5 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA Kinesin PF00225.23 KPI89855.1 - 1.6e-101 339.6 0.4 1.4e-57 195.2 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KPI89855.1 - 2.2e-21 76.4 0.0 1.3e-20 73.8 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding AAA_16 PF13191.6 KPI89855.1 - 0.00018 21.9 2.9 0.033 14.6 0.0 3.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KPI89855.1 - 0.00034 20.9 1.1 0.28 11.5 0.0 3.7 4 0 0 4 4 4 1 AAA domain RsgA_GTPase PF03193.16 KPI89855.1 - 0.0028 17.6 0.0 0.033 14.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase IstB_IS21 PF01695.17 KPI89855.1 - 0.0032 17.2 0.1 0.75 9.5 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein Kinesin_assoc PF16183.5 KPI89855.1 - 0.016 15.4 3.3 0.12 12.5 0.0 3.3 3 0 0 3 3 3 0 Kinesin-associated AAA_29 PF13555.6 KPI89855.1 - 0.022 14.5 0.0 0.7 9.7 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 KPI89855.1 - 0.026 13.9 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Roc PF08477.13 KPI89855.1 - 0.029 14.6 0.0 0.74 10.0 0.0 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 KPI89855.1 - 0.04 13.6 0.2 0.57 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KPI89855.1 - 0.049 14.1 0.2 0.31 11.6 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.6 KPI89855.1 - 0.076 13.3 0.0 0.076 13.3 0.0 2.8 3 0 0 3 3 2 0 AAA domain Ras PF00071.22 KPI89855.1 - 0.11 12.1 0.0 4.7 6.8 0.0 2.9 2 1 0 2 2 2 0 Ras family AAA_7 PF12775.7 KPI89855.1 - 0.16 11.4 0.1 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region SRPRB PF09439.10 KPI89855.1 - 0.17 11.3 0.0 0.62 9.5 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 KPI89855.1 - 0.19 11.6 0.1 2.4 8.0 0.0 2.8 3 0 0 3 3 3 0 NACHT domain RNA_helicase PF00910.22 KPI89855.1 - 0.2 12.0 0.1 7.8 6.9 0.0 2.7 3 0 0 3 3 2 0 RNA helicase MMR_HSR1 PF01926.23 KPI89855.1 - 0.24 11.5 0.4 15 5.7 0.1 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Pinin_SDK_memA PF04696.13 KPI89855.1 - 0.7 10.0 4.4 10 6.2 4.0 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region AAA_33 PF13671.6 KPI89855.1 - 2.4 8.3 6.0 1.9 8.6 0.0 3.3 3 0 0 3 3 2 0 AAA domain Peptidase_M17 PF00883.21 KPI89856.1 - 1.7e-94 316.6 0.2 2.4e-94 316.1 0.2 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 KPI89856.1 - 6.4e-32 110.4 0.4 1.5e-31 109.2 0.4 1.7 1 0 0 1 1 1 1 M17 aminopeptidase N-terminal domain 2 Frag1 PF10277.9 KPI89858.1 - 8.5e-30 103.9 17.6 8.5e-30 103.9 17.6 3.6 3 1 0 4 4 4 1 Frag1/DRAM/Sfk1 family DUF1639 PF07797.14 KPI89858.1 - 0.085 12.8 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) TBCC PF07986.12 KPI89859.1 - 5.2e-22 77.8 7.7 1.2e-20 73.5 7.7 2.3 1 1 0 1 1 1 1 Tubulin binding cofactor C LST1 PF05083.13 KPI89859.1 - 0.079 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 LST-1 protein AAA_6 PF12774.7 KPI89860.1 - 1.3e-124 415.4 0.0 5.5e-124 413.4 0.0 2.2 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI89860.1 - 7.1e-107 358.0 9.3 7.1e-107 358.0 9.3 5.0 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KPI89860.1 - 3.1e-65 219.4 3.7 3.1e-65 219.4 3.7 3.6 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 KPI89860.1 - 3.4e-50 170.8 0.1 5.9e-49 166.7 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 KPI89860.1 - 1.2e-31 109.5 0.0 1.6e-19 70.3 0.0 5.7 5 1 0 5 5 4 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KPI89860.1 - 2.1e-31 108.8 0.0 1.8e-26 92.8 0.0 4.2 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KPI89860.1 - 1.4e-28 99.7 0.0 3.5e-28 98.5 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI89860.1 - 1.5e-26 92.8 0.0 8.4e-26 90.4 0.0 2.5 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI89860.1 - 1.2e-25 90.3 7.2 2.5e-25 89.3 7.2 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 KPI89860.1 - 1.6e-23 83.4 0.0 1.6e-23 83.4 0.0 3.1 4 0 0 4 4 3 1 Dynein heavy chain C-terminal domain AAA_16 PF13191.6 KPI89860.1 - 2e-16 60.8 0.3 0.00061 20.2 0.0 6.4 4 1 0 4 4 4 3 AAA ATPase domain AAA_22 PF13401.6 KPI89860.1 - 3.2e-11 43.6 4.4 0.056 13.7 0.0 6.9 6 0 0 6 6 5 2 AAA domain AAA PF00004.29 KPI89860.1 - 2.6e-10 40.8 0.3 0.15 12.5 0.0 6.6 6 0 0 6 6 5 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KPI89860.1 - 1.3e-05 25.4 0.1 0.017 15.3 0.0 4.3 4 0 0 4 4 3 1 AAA domain ABC_tran PF00005.27 KPI89860.1 - 1.6e-05 25.5 3.2 0.0038 17.7 0.0 4.9 5 0 0 5 5 4 1 ABC transporter AAA_18 PF13238.6 KPI89860.1 - 3.1e-05 24.5 0.0 0.071 13.7 0.0 4.2 4 0 0 4 4 3 1 AAA domain AAA_28 PF13521.6 KPI89860.1 - 7e-05 23.1 0.0 0.034 14.4 0.0 4.1 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 KPI89860.1 - 9.9e-05 22.7 0.0 1.9 8.9 0.0 4.0 3 0 0 3 3 3 1 RNA helicase RsgA_GTPase PF03193.16 KPI89860.1 - 0.00017 21.5 6.9 0.0002 21.3 0.1 3.8 4 0 0 4 4 3 1 RsgA GTPase AAA_24 PF13479.6 KPI89860.1 - 0.00018 21.3 0.2 0.12 12.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 KPI89860.1 - 0.00053 19.8 0.3 0.31 10.7 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KPI89860.1 - 0.00099 18.8 0.0 0.027 14.2 0.0 3.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain Rad17 PF03215.15 KPI89860.1 - 0.016 15.1 0.5 0.68 9.8 0.0 3.4 3 0 0 3 3 3 0 Rad17 P-loop domain Zeta_toxin PF06414.12 KPI89860.1 - 0.028 13.7 0.0 1.5 8.0 0.0 3.3 3 0 0 3 3 3 0 Zeta toxin ATPase_2 PF01637.18 KPI89860.1 - 0.046 13.6 7.3 0.12 12.2 0.0 3.7 4 0 0 4 4 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KPI89860.1 - 0.046 13.7 0.2 1 9.4 0.0 3.0 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_lid_7 PF17867.1 KPI89860.1 - 0.068 13.4 0.0 0.41 10.9 0.0 2.5 1 0 0 1 1 1 0 Midasin AAA lid domain cobW PF02492.19 KPI89860.1 - 0.084 12.5 0.5 10 5.7 0.2 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 KPI89860.1 - 0.09 12.6 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 KPI89860.1 - 0.14 12.1 3.1 2.9 7.8 0.1 3.4 3 0 0 3 3 2 0 NACHT domain T2SSE PF00437.20 KPI89860.1 - 0.97 8.4 6.3 0.099 11.7 0.0 2.6 4 0 0 4 4 2 0 Type II/IV secretion system protein FAP206 PF12018.8 KPI89860.1 - 0.99 8.9 11.0 6.6 6.1 5.4 3.8 2 1 1 3 3 3 0 Domain of unknown function DUF4201 PF13870.6 KPI89860.1 - 2 8.1 33.8 0.065 13.0 5.3 5.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4201) AAA_23 PF13476.6 KPI89860.1 - 2.1 8.8 0.0 2.1 8.8 0.0 6.2 6 1 0 6 6 4 0 AAA domain Laminin_II PF06009.12 KPI89860.1 - 5.9 6.9 28.3 0.4 10.7 13.8 5.0 4 0 0 4 4 3 0 Laminin Domain II DUF778 PF05608.12 KPI89861.1 - 0.035 14.5 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF778) DUF2280 PF10045.9 KPI89862.1 - 0.33 11.2 2.4 1.3 9.3 0.2 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2280) SPACA9 PF15120.6 KPI89862.1 - 0.49 10.2 3.6 3.6 7.3 0.0 2.6 2 1 0 2 2 2 0 Sperm acrosome-associated protein 9 PGK PF00162.19 KPI89863.1 - 1e-83 281.4 0.0 1.4e-83 281.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoglycerate kinase cNMP_binding PF00027.29 KPI89863.1 - 2.8e-07 30.5 0.0 6.1e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain eRF1_2 PF03464.15 KPI89864.1 - 3e-40 137.6 0.0 5.7e-40 136.7 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KPI89864.1 - 3e-35 121.1 0.5 9.3e-35 119.5 0.5 1.9 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 KPI89864.1 - 3.5e-12 46.4 0.3 7.1e-12 45.5 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 1 baeRF_family10 PF18854.1 KPI89864.1 - 4.5e-09 36.7 0.0 8.9e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 KPI89864.1 - 6.1e-08 33.0 0.0 1e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor T3RM_EcoP15I_C PF18273.1 KPI89864.1 - 0.048 14.0 0.2 4.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Type III R-M EcoP15I C-terminal domain Phage_Nu1 PF07471.12 KPI89864.1 - 0.19 11.5 2.2 0.33 10.7 0.0 2.3 2 1 1 3 3 3 0 Phage DNA packaging protein Nu1 ABC_tran PF00005.27 KPI89865.1 - 0.0013 19.2 0.0 0.0024 18.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter LRR_4 PF12799.7 KPI89866.1 - 0.00053 20.3 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) zf_CCCH_4 PF18345.1 KPI89866.1 - 0.02 14.9 1.1 0.1 12.7 1.1 2.1 1 1 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 KPI89866.1 - 0.028 14.3 2.2 0.059 13.3 2.2 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KPI89866.1 - 0.046 14.2 3.1 0.1 13.1 3.1 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger LRR_9 PF14580.6 KPI89866.1 - 0.094 12.2 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat zf-CCCH_4 PF18044.1 KPI89866.1 - 0.14 12.0 1.8 0.43 10.5 1.8 1.9 1 0 0 1 1 1 0 CCCH-type zinc finger LRR_8 PF13855.6 KPI89866.1 - 0.19 11.5 0.2 0.45 10.3 0.2 1.6 1 0 0 1 1 1 0 Leucine rich repeat LRR_9 PF14580.6 KPI89867.1 - 0.00048 19.7 0.5 0.00094 18.7 0.5 1.4 1 0 0 1 1 1 1 Leucine-rich repeat RasGEF PF00617.19 KPI89868.1 - 2.2e-20 73.6 0.0 4e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 KPI89868.1 - 0.0007 19.8 0.3 0.0024 18.1 0.1 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif ThiF PF00899.21 KPI89869.1 - 1.3e-63 214.7 0.0 1.9e-63 214.1 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 KPI89869.1 - 0.00025 21.5 0.0 0.0006 20.3 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain UDPG_MGDP_dh_N PF03721.14 KPI89869.1 - 0.033 13.8 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 KPI89869.1 - 0.081 13.2 0.1 0.2 11.9 0.1 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 KPI89869.1 - 0.14 12.2 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Strumpellin PF10266.9 KPI89870.1 - 0 1248.6 0.0 0 1248.3 0.0 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Ank_2 PF12796.7 KPI89872.1 - 4.4e-14 52.8 3.6 4e-10 40.1 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI89872.1 - 3.1e-13 48.6 4.6 0.0005 20.3 0.0 5.1 3 1 1 4 4 4 3 Ankyrin repeat Ank PF00023.30 KPI89872.1 - 7.1e-12 45.2 5.9 2.2e-05 24.7 0.1 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KPI89872.1 - 8.7e-10 38.9 2.8 0.00059 20.4 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI89872.1 - 8.9e-09 35.5 8.1 6.4e-06 26.3 0.2 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) DUF2274 PF10038.9 KPI89872.1 - 0.13 12.7 0.6 35 5.0 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2274) BRO1 PF03097.18 KPI89874.1 - 4.8e-62 210.0 0.1 4.8e-62 210.0 0.1 2.6 2 1 1 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KPI89874.1 - 1.8e-24 86.6 8.9 1.8e-24 86.6 8.9 2.7 1 1 1 2 2 2 1 ALIX V-shaped domain binding to HIV DUF1282 PF06930.12 KPI89874.1 - 0.055 13.3 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) MIT PF04212.18 KPI89874.1 - 0.061 13.4 3.7 0.43 10.7 0.0 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Spc7 PF08317.11 KPI89874.1 - 0.4 9.5 33.6 0.89 8.4 12.0 3.5 2 1 1 3 3 3 0 Spc7 kinetochore protein TEX12 PF15219.6 KPI89874.1 - 0.42 11.0 4.3 0.37 11.2 0.4 2.8 2 1 1 3 3 3 0 Testis-expressed 12 Latarcin PF10279.9 KPI89874.1 - 1.2 9.6 10.9 29 5.2 1.1 4.3 2 1 1 3 3 3 0 Latarcin precursor Baculo_PEP_C PF04513.12 KPI89874.1 - 1.7 8.7 14.8 0.48 10.4 2.2 3.9 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus RICH PF05062.12 KPI89874.1 - 1.8 9.0 5.9 4.4 7.7 0.2 3.6 3 1 0 3 3 3 0 RICH domain UPF0242 PF06785.11 KPI89874.1 - 5.4 7.1 27.1 0.27 11.3 15.0 2.8 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus WD40 PF00400.32 KPI89875.1 - 1e-05 26.1 10.0 6.8 7.7 0.0 6.7 7 1 0 7 7 7 3 WD domain, G-beta repeat IF4E PF01652.18 KPI89876.1 - 5.3e-47 159.6 0.3 6.2e-47 159.4 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E HC2 PF07382.11 KPI89877.1 - 0.058 13.5 49.6 0.065 13.3 49.6 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 AAA_6 PF12774.7 KPI89879.1 - 4e-156 519.0 0.0 2e-153 510.2 0.0 3.2 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KPI89879.1 - 9.1e-115 383.9 5.1 9.1e-115 383.9 5.1 2.5 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KPI89879.1 - 1.1e-107 359.8 0.0 3.6e-107 358.1 0.0 1.9 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KPI89879.1 - 1.7e-92 309.5 0.0 1.3e-91 306.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KPI89879.1 - 1.7e-76 255.8 0.0 1e-73 246.7 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_9 PF12781.7 KPI89879.1 - 8.9e-76 253.9 4.6 2.5e-75 252.4 4.6 1.9 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 KPI89879.1 - 2e-59 200.1 0.0 6.8e-59 198.4 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KPI89879.1 - 5.4e-40 136.2 0.0 1.3e-36 125.3 0.0 3.0 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain MT PF12777.7 KPI89879.1 - 1.8e-25 89.7 10.4 1.8e-25 89.7 10.4 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KPI89879.1 - 2.9e-19 69.5 0.0 0.00034 20.6 0.0 6.9 6 1 0 6 6 6 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KPI89879.1 - 4.3e-19 68.9 2.0 8.9e-19 67.9 0.1 2.7 3 0 0 3 3 2 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KPI89879.1 - 1.5e-14 54.0 0.1 5.8e-14 52.1 0.1 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KPI89879.1 - 4.2e-08 33.5 3.3 0.089 13.1 0.0 6.1 5 1 1 6 6 5 2 AAA domain AAA PF00004.29 KPI89879.1 - 5.2e-08 33.4 2.0 0.0079 16.6 0.0 3.6 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KPI89879.1 - 6.8e-05 23.4 0.2 0.0054 17.3 0.0 4.0 3 0 0 3 3 3 1 AAA domain Cluap1 PF10234.9 KPI89879.1 - 0.0024 17.3 3.2 0.0024 17.3 3.2 3.9 3 0 0 3 3 1 1 Clusterin-associated protein-1 AAA_16 PF13191.6 KPI89879.1 - 0.0025 18.2 10.8 0.28 11.6 0.0 6.4 7 0 0 7 7 4 1 AAA ATPase domain AAA_33 PF13671.6 KPI89879.1 - 0.0031 17.7 0.2 6.6 6.9 0.0 4.0 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 KPI89879.1 - 0.0037 17.6 0.4 4.1 7.8 0.0 3.2 3 0 0 3 3 3 1 RNA helicase T2SSE PF00437.20 KPI89879.1 - 0.0044 16.1 0.6 0.026 13.6 0.0 2.7 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF815 PF05673.13 KPI89879.1 - 0.017 14.3 0.0 0.051 12.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.17 KPI89879.1 - 0.037 14.0 1.8 1.9 8.5 0.0 3.4 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 KPI89879.1 - 0.092 12.4 12.1 0.14 11.9 0.0 3.9 4 0 0 4 4 4 0 AAA domain MobB PF03205.14 KPI89879.1 - 0.12 12.2 0.0 0.42 10.5 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 KPI89879.1 - 0.18 12.3 0.9 6 7.4 0.0 3.4 2 0 0 2 2 2 0 ABC transporter FtsK_SpoIIIE PF01580.18 KPI89879.1 - 0.19 11.0 1.7 9.8 5.4 0.1 3.2 3 0 0 3 3 3 0 FtsK/SpoIIIE family 6PF2K PF01591.18 KPI89879.1 - 0.23 10.7 1.2 5.4 6.3 0.1 2.7 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA_2 PF07724.14 KPI89879.1 - 0.33 11.0 2.0 6.1 6.9 0.0 3.3 3 0 0 3 3 2 0 AAA domain (Cdc48 subfamily) dCache_1 PF02743.18 KPI89879.1 - 6.9 6.4 6.4 6 6.6 0.8 3.2 4 0 0 4 4 3 0 Cache domain Nop25 PF09805.9 KPI89880.1 - 0.28 11.7 8.5 0.39 11.2 8.5 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TTL PF03133.15 KPI89881.1 - 4e-52 177.2 0.0 5.5e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KPI89881.1 - 1.1e-05 24.8 0.0 1.3 8.2 0.0 3.2 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KPI89881.1 - 0.0035 16.6 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Prp19 PF08606.11 KPI89882.1 - 3e-22 78.4 0.3 6.9e-22 77.2 0.3 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 KPI89882.1 - 1e-10 42.0 7.2 0.0083 17.0 0.0 5.5 6 1 0 6 6 6 3 WD domain, G-beta repeat zf-Nse PF11789.8 KPI89882.1 - 1.5e-06 27.9 0.7 2.7e-06 27.1 0.7 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 KPI89882.1 - 4e-05 23.7 0.0 0.0001 22.4 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 KPI89882.1 - 0.00097 18.9 0.2 0.00097 18.9 0.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ANAPC4_WD40 PF12894.7 KPI89882.1 - 0.003 17.8 0.0 4.2 7.7 0.0 3.9 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KPI89882.1 - 0.053 12.5 0.8 5.4 5.9 0.0 3.0 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-RING_2 PF13639.6 KPI89882.1 - 0.069 13.5 3.5 0.076 13.4 0.5 2.3 2 0 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.7 KPI89882.1 - 0.085 13.2 0.2 0.19 12.0 0.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KPI89882.1 - 0.53 10.4 4.2 0.13 12.3 0.5 2.1 2 0 0 2 2 2 0 RING-type zinc-finger Pkinase PF00069.25 KPI89883.1 - 2.2e-69 233.8 0.0 3.5e-69 233.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89883.1 - 3.5e-32 111.7 0.0 5.1e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89883.1 - 1.5e-06 27.8 0.0 0.00075 18.9 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 KPI89883.1 - 0.00093 18.6 2.3 0.016 14.6 0.1 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI89883.1 - 0.0012 18.9 0.0 0.36 10.7 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 KPI89883.1 - 0.015 14.9 0.1 1.2 8.7 0.0 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KPI89883.1 - 0.06 12.1 0.0 0.1 11.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 KPI89884.1 - 1.6e-48 165.4 0.0 2e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89884.1 - 5e-23 81.7 0.0 6.7e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI89884.1 - 2.6e-05 24.3 0.2 0.0014 18.6 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI89884.1 - 5.1e-05 22.7 0.0 0.00013 21.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KPI89884.1 - 0.019 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KPI89884.1 - 0.093 11.5 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APG6_N PF17675.1 KPI89885.1 - 0.01 16.3 1.3 5.4 7.5 0.0 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region AIP3 PF03915.13 KPI89885.1 - 0.012 14.8 0.4 0.41 9.7 0.2 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 CENP-F_leu_zip PF10473.9 KPI89885.1 - 0.055 13.5 3.0 6.6 6.8 0.1 2.6 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4164 PF13747.6 KPI89885.1 - 0.2 11.9 9.0 1.1 9.6 0.8 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4164) BRE1 PF08647.11 KPI89885.1 - 0.66 10.1 3.1 0.92 9.6 1.1 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 KPI89885.1 - 1.8 8.6 6.6 2.7 8.1 2.2 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 KPI89885.1 - 8.3 5.7 6.9 1.3 8.4 1.1 2.4 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding adh_short_C2 PF13561.6 KPI89886.1 - 2.5e-41 141.8 0.2 3.8e-41 141.2 0.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KPI89886.1 - 6.7e-39 133.4 0.1 1e-38 132.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KPI89886.1 - 1.6e-15 57.4 0.3 6.6e-15 55.5 0.3 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KPI89886.1 - 2.1e-06 27.4 0.0 4.5e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KPI89886.1 - 0.0034 16.5 0.0 0.0055 15.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain CaATP_NAI PF12515.8 KPI89886.1 - 0.056 13.1 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain DKCLD PF08068.12 KPI89886.1 - 0.17 12.0 0.0 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 DKCLD (NUC011) domain TBPIP PF07106.13 KPI89888.1 - 1.7e-09 37.4 0.0 2.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain Aldo_ket_red PF00248.21 KPI89889.1 - 6.3e-38 130.6 0.0 1.2e-37 129.8 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family DnaJ_C PF01556.18 KPI89890.1 - 2.2e-33 115.5 0.0 2.8e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI89890.1 - 1.4e-28 98.7 1.8 2.6e-28 97.9 1.8 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KPI89890.1 - 5.3e-13 49.1 17.4 8.5e-13 48.5 17.4 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KPI89890.1 - 0.62 10.1 14.8 0.52 10.3 3.8 2.8 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KPI89890.1 - 1.8 8.6 10.1 1.3 9.1 1.4 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TPR_1 PF00515.28 KPI89891.1 - 3e-13 49.0 9.1 0.00052 19.7 1.7 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI89891.1 - 3.6e-12 45.4 12.4 0.00059 19.8 2.7 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat RPAP3_C PF13877.6 KPI89891.1 - 4.9e-12 46.2 0.1 1.2e-11 44.9 0.0 1.7 2 0 0 2 2 1 1 Potential Monad-binding region of RPAP3 TPR_8 PF13181.6 KPI89891.1 - 1.9e-09 37.0 3.8 0.012 15.8 0.9 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 KPI89891.1 - 1.1e-07 31.9 7.2 0.055 13.6 1.1 4.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 KPI89891.1 - 1e-05 25.6 2.1 0.077 13.4 0.0 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89891.1 - 0.00037 21.1 4.9 0.0047 17.6 3.0 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KPI89891.1 - 0.00038 20.1 6.6 0.0035 17.0 0.0 3.5 4 1 0 4 4 4 1 TPR repeat TPR_19 PF14559.6 KPI89891.1 - 0.00059 20.3 10.0 0.0083 16.6 0.1 3.2 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI89891.1 - 0.0073 16.9 0.1 0.0073 16.9 0.1 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI89891.1 - 0.11 12.7 3.1 0.33 11.2 3.1 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KPI89891.1 - 0.59 10.5 12.4 16 5.9 1.5 3.8 2 1 0 3 3 3 0 Tetratricopeptide repeat Menin PF05053.13 KPI89891.1 - 1.2 7.5 11.5 1.9 6.7 11.5 1.3 1 0 0 1 1 1 0 Menin HHV-5_US34A PF17087.5 KPI89893.1 - 0.18 12.0 1.3 0.52 10.5 0.7 2.0 2 1 0 2 2 2 0 Herpesvirus US34A protein family FliT PF05400.13 KPI89894.1 - 0.0021 18.8 0.7 0.01 16.6 0.4 2.3 2 0 0 2 2 2 1 Flagellar protein FliT DUF4141 PF13605.6 KPI89894.1 - 0.014 14.6 0.0 0.044 13.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) GerD PF17898.1 KPI89894.1 - 0.099 12.6 1.1 1.1 9.3 1.0 2.6 3 1 0 3 3 3 0 Spore germination GerD central core domain DUF1487 PF07368.11 KPI89894.1 - 0.13 11.7 0.1 0.26 10.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Synaptobrevin PF00957.21 KPI89895.1 - 1.7e-26 91.8 0.8 2.8e-26 91.1 0.2 1.6 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 KPI89895.1 - 5.1e-11 42.5 0.3 8.7e-11 41.7 0.3 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF2937 PF11157.8 KPI89895.1 - 0.05 13.3 1.0 2.3 7.9 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2937) Wzz PF02706.15 KPI89895.1 - 0.85 10.0 5.1 3.3 8.1 5.1 1.9 1 0 0 1 1 1 0 Chain length determinant protein Glyco_hydro_32N PF00251.20 KPI89896.1 - 1.5e-90 303.9 3.0 1.8e-90 303.6 3.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 KPI89896.1 - 6.5e-21 75.0 0.0 9.7e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal RcnB PF11776.8 KPI89896.1 - 0.15 12.2 1.3 12 6.1 0.3 3.2 3 0 0 3 3 3 0 Nickel/cobalt transporter regulator YchF-GTPase_C PF06071.13 KPI89898.1 - 3.9e-38 129.5 0.1 1e-37 128.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KPI89898.1 - 6.8e-22 77.7 0.0 1.8e-21 76.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI89898.1 - 0.0001 21.8 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 KPI89898.1 - 0.012 15.8 0.0 0.31 11.3 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TGS PF02824.21 KPI89898.1 - 0.023 14.7 0.1 0.068 13.2 0.0 1.8 2 0 0 2 2 2 0 TGS domain AAA_18 PF13238.6 KPI89898.1 - 0.026 15.1 0.0 0.17 12.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 KPI89898.1 - 0.036 13.1 0.0 0.058 12.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 KPI89898.1 - 0.062 13.4 0.4 5.7 7.0 0.1 2.8 2 1 1 3 3 3 0 Dynamin family ABC_tran PF00005.27 KPI89898.1 - 0.09 13.3 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 ABC transporter PP2C PF00481.21 KPI89899.1 - 2.8e-77 259.8 0.0 3.7e-77 259.5 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3839 PF12943.7 KPI89899.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3839) MORN PF02493.20 KPI89901.1 - 6.1e-19 66.7 27.2 1.1e-06 28.2 1.3 5.1 6 0 0 6 6 6 4 MORN repeat DUF2724 PF10893.8 KPI89901.1 - 0.1 12.5 0.3 15 5.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2724) DUF3048_C PF17479.2 KPI89901.1 - 0.11 12.9 4.3 0.78 10.2 1.7 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain Spt5-NGN PF03439.13 KPI89902.1 - 3.6e-21 74.9 0.1 1.1e-20 73.3 0.1 1.9 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 KPI89902.1 - 4.1e-06 26.6 2.1 0.041 13.8 0.0 4.0 3 0 0 3 3 3 2 KOW motif HAS-barrel PF09378.10 KPI89902.1 - 0.0068 16.5 0.1 0.27 11.4 0.0 2.6 2 0 0 2 2 2 1 HAS barrel domain ACOX PF01756.19 KPI89903.1 - 4.5e-07 29.6 0.0 1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Mcp5_PH PF12814.7 KPI89904.1 - 2.6e-14 53.4 0.4 4.6e-14 52.6 0.4 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 KPI89904.1 - 0.0026 18.3 0.4 0.005 17.3 0.4 1.5 1 0 0 1 1 1 1 PH domain EMG1 PF03587.14 KPI89907.1 - 1.3e-37 129.3 0.0 1.8e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Atg14 PF10186.9 KPI89908.1 - 0.0014 17.8 0.3 0.0024 17.0 0.3 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_S27e PF01667.17 KPI89910.1 - 1 9.1 5.9 0.44 10.3 1.1 3.0 2 0 0 2 2 2 0 Ribosomal protein S27 Ribosomal_L11_N PF03946.14 KPI89911.1 - 1.9e-15 56.4 0.0 3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 KPI89911.1 - 6.2e-15 55.5 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DSPc PF00782.20 KPI89912.1 - 1.8e-24 86.0 0.1 2.8e-24 85.4 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI89912.1 - 0.0011 18.6 0.1 0.0014 18.2 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Thioredoxin PF00085.20 KPI89913.1 - 6.7e-07 29.3 0.1 1.3e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 KPI89913.1 - 7.6e-07 28.3 0.5 8.6e-07 28.2 0.5 1.1 1 0 0 1 1 1 1 Phosducin CENP-Q PF13094.6 KPI89913.1 - 0.0055 16.9 4.1 0.0092 16.2 4.1 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF3394 PF11874.8 KPI89913.1 - 0.027 14.2 0.6 0.042 13.5 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) hNIFK_binding PF12196.8 KPI89913.1 - 0.74 9.4 4.2 1.1 8.9 2.4 2.1 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK VKOR PF07884.14 KPI89914.1 - 8.9e-18 64.7 18.0 1e-17 64.4 18.0 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family NIF PF03031.18 KPI89915.1 - 3.7e-26 91.7 0.0 6.1e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase WD40 PF00400.32 KPI89917.1 - 2.2e-06 28.3 0.0 0.039 14.8 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Fez1 PF06818.15 KPI89917.1 - 0.0016 19.0 24.2 0.0016 19.0 24.2 4.1 1 1 2 3 3 3 1 Fez1 DUF4201 PF13870.6 KPI89917.1 - 0.0067 16.2 16.7 0.0067 16.2 16.7 5.8 3 1 1 6 6 6 1 Domain of unknown function (DUF4201) Fzo_mitofusin PF04799.13 KPI89917.1 - 0.049 13.2 0.3 0.049 13.2 0.3 5.9 2 1 5 7 7 7 0 fzo-like conserved region Ge1_WD40 PF16529.5 KPI89917.1 - 0.06 12.3 0.3 0.12 11.3 0.0 1.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PKcGMP_CC PF16808.5 KPI89917.1 - 4.6 7.2 23.9 0.51 10.2 2.2 5.8 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase LMBR1 PF04791.16 KPI89919.1 - 7.6 5.3 9.5 2.4 6.9 7.0 1.4 2 0 0 2 2 2 0 LMBR1-like membrane protein PI3_PI4_kinase PF00454.27 KPI89920.1 - 8e-19 68.4 0.0 4.9e-18 65.8 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF1465 PF07323.12 KPI89920.1 - 0.036 13.9 0.1 0.077 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) DUF4614 PF15391.6 KPI89920.1 - 0.43 10.6 2.7 0.79 9.7 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CAP PF00188.26 KPI89921.1 - 2.5 9.0 5.0 13 6.6 0.2 2.9 3 0 0 3 3 3 0 Cysteine-rich secretory protein family Motile_Sperm PF00635.26 KPI89922.1 - 6.6e-06 25.9 0.0 1.6e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 MSP (Major sperm protein) domain PPI_Ypi1 PF07491.11 KPI89922.1 - 0.18 11.6 0.0 0.47 10.3 0.0 1.7 1 0 0 1 1 1 0 Protein phosphatase inhibitor Lipase_3 PF01764.25 KPI89923.1 - 1e-13 51.3 0.0 5.9e-13 48.9 0.0 2.2 2 1 0 2 2 2 1 Lipase (class 3) C1_1 PF00130.22 KPI89923.1 - 0.0064 16.4 2.0 0.044 13.7 0.9 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 KPI89923.1 - 0.008 16.5 1.2 0.1 12.9 0.1 2.7 2 0 0 2 2 2 1 C1 domain DUF3323 PF11796.8 KPI89923.1 - 0.016 15.1 8.2 0.025 14.5 5.7 2.3 1 1 1 2 2 2 0 Protein of unknown function N-terminus (DUF3323) Hydrolase_4 PF12146.8 KPI89923.1 - 0.03 13.6 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 KPI89923.1 - 0.039 13.5 0.0 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) RRM_1 PF00076.22 KPI89924.1 - 2.3e-31 107.4 0.1 5.3e-11 42.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KPI89924.1 - 7.2e-14 51.5 0.1 4.3e-05 23.4 0.0 3.3 3 0 0 3 3 3 3 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KPI89924.1 - 1.4e-11 44.1 0.0 3.1e-05 23.8 0.0 3.2 3 0 0 3 3 3 3 Occluded RNA-recognition motif zf-CCHC PF00098.23 KPI89924.1 - 0.0018 18.3 2.3 0.0018 18.3 2.3 3.0 3 0 0 3 3 3 1 Zinc knuckle PHM7_cyt PF14703.6 KPI89924.1 - 0.016 15.4 0.4 17 5.6 0.0 3.4 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 KPI89924.1 - 0.021 14.9 0.0 3.2 7.9 0.0 2.7 3 0 0 3 3 3 0 RNA recognition motif RRM_3 PF08777.11 KPI89924.1 - 0.067 13.2 0.0 3.6 7.7 0.0 2.6 3 0 0 3 3 3 0 RNA binding motif zf-CCHC_2 PF13696.6 KPI89924.1 - 0.076 12.9 9.4 1.7 8.6 2.9 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-B_box PF00643.24 KPI89924.1 - 0.2 11.8 4.5 1.1 9.5 1.1 2.4 2 0 0 2 2 2 0 B-box zinc finger zf-CCHC_4 PF14392.6 KPI89924.1 - 0.71 9.7 8.0 3.7 7.4 0.6 2.4 1 1 1 2 2 2 0 Zinc knuckle OCRE PF17780.1 KPI89927.1 - 0.00045 20.2 2.4 0.0012 18.8 2.4 1.7 1 0 0 1 1 1 1 OCRE domain Ribonuc_red_sm PF00268.21 KPI89929.1 - 1.1e-110 369.5 0.0 1.4e-110 369.2 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain NMT PF01233.19 KPI89929.1 - 0.013 15.3 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Erv26 PF04148.13 KPI89930.1 - 2.2e-19 70.1 6.1 6e-19 68.7 6.1 1.6 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 CaATP_NAI PF12515.8 KPI89930.1 - 0.041 13.5 0.2 0.073 12.7 0.2 1.5 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Aminotran_4 PF01063.19 KPI89931.1 - 9.8e-32 110.6 0.0 2.2e-31 109.5 0.0 1.6 1 0 0 1 1 1 1 Amino-transferase class IV Mito_carr PF00153.27 KPI89932.1 - 1.2e-29 102.1 3.8 9e-16 57.6 0.4 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein FAD-oxidase_C PF02913.19 KPI89933.1 - 3.6e-40 138.2 0.0 4.8e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KPI89933.1 - 2.8e-36 124.3 0.8 6.4e-36 123.1 0.8 1.7 1 0 0 1 1 1 1 FAD binding domain GMP_PDE_delta PF05351.11 KPI89935.1 - 2e-62 209.9 0.1 2.3e-62 209.7 0.1 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit Cadherin_3 PF16184.5 KPI89935.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Cadherin-like tRNA_edit PF04073.15 KPI89936.1 - 1.4e-17 63.9 0.2 1.9e-17 63.5 0.2 1.2 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Complex1_LYR PF05347.15 KPI89937.1 - 4.9e-15 55.3 0.7 4.9e-15 55.3 0.7 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KPI89937.1 - 7e-05 23.5 0.3 0.00016 22.4 0.3 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Cmc1 PF08583.10 KPI89940.1 - 0.0055 16.7 0.7 0.011 15.7 0.7 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like zf-C3HC4_3 PF13920.6 KPI89942.1 - 1.4e-15 56.9 11.0 2.2e-15 56.2 11.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI89942.1 - 4.4e-07 30.1 12.2 7.6e-07 29.4 12.2 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KPI89942.1 - 7.9e-07 28.8 12.2 1.4e-06 28.0 12.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KPI89942.1 - 0.00037 20.3 15.5 0.00061 19.6 15.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_2 PF13240.6 KPI89942.1 - 0.0034 17.0 0.8 0.0074 16.0 0.8 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-RING_5 PF14634.6 KPI89942.1 - 0.017 15.1 11.9 0.031 14.2 11.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-P11 PF03854.14 KPI89942.1 - 0.1 12.3 8.8 0.19 11.4 8.8 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-C4H2 PF10146.9 KPI89942.1 - 0.37 11.1 12.8 0.033 14.5 2.3 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein Spt20 PF12090.8 KPI89942.1 - 8.1 6.0 17.8 0.36 10.4 11.7 1.9 2 0 0 2 2 2 0 Spt20 family APG6_N PF17675.1 KPI89943.1 - 0.0022 18.5 1.4 0.0022 18.5 1.4 10.0 3 1 6 9 9 9 1 Apg6 coiled-coil region DUF3563 PF12086.8 KPI89943.1 - 0.19 11.5 4.1 22 4.9 0.0 4.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3563) Ras PF00071.22 KPI89944.1 - 9e-52 174.9 0.0 1.7e-51 174.0 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KPI89944.1 - 1.1e-31 109.6 0.0 1.3e-30 106.1 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI89944.1 - 1.6e-11 44.0 0.0 2e-10 40.4 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KPI89944.1 - 5.6e-05 22.6 0.0 7.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 KPI89944.1 - 0.0049 16.6 0.0 0.049 13.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KPI89944.1 - 0.0093 16.0 0.0 0.023 14.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI89944.1 - 0.014 15.3 0.2 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 KPI89944.1 - 0.02 15.4 0.1 0.045 14.3 0.1 1.5 1 1 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 KPI89944.1 - 0.037 13.5 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain zf-AN1 PF01428.16 KPI89945.1 - 3.6e-18 65.4 32.1 2.9e-11 43.4 5.6 3.1 2 1 1 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 KPI89945.1 - 0.00021 21.6 18.4 0.014 15.7 1.9 2.6 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain zf-H2C2_2 PF13465.6 KPI89945.1 - 1.9 9.1 10.3 19 5.9 0.1 4.0 3 1 0 3 3 3 0 Zinc-finger double domain IBR PF01485.21 KPI89945.1 - 3.1 8.1 27.4 0.071 13.3 3.8 2.9 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Methyltr_RsmB-F PF01189.17 KPI89946.1 - 4.1e-33 114.7 0.0 6.8e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KPI89946.1 - 0.00098 19.3 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ank_4 PF13637.6 KPI89947.1 - 9.6e-24 83.5 0.5 1.4e-16 60.6 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KPI89947.1 - 3e-22 79.0 0.2 8.2e-12 45.6 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KPI89947.1 - 1.2e-21 74.5 0.1 4.4e-06 26.6 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KPI89947.1 - 8.2e-20 70.6 2.5 3.8e-08 33.4 0.0 5.5 3 3 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KPI89947.1 - 3.6e-16 58.8 0.2 2.8e-05 24.3 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat FUSC-like PF12805.7 KPI89947.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS PDEase_I PF00233.19 KPI89948.1 - 6e-76 255.3 0.0 9.9e-76 254.6 0.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DegS PF05384.11 KPI89948.1 - 0.019 14.5 1.7 0.036 13.6 1.7 1.4 1 0 0 1 1 1 0 Sensor protein DegS CCDC-167 PF15188.6 KPI89948.1 - 1.4 9.3 4.6 14 6.1 4.7 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Pkinase PF00069.25 KPI89949.1 - 2.2e-73 246.9 0.0 2.6e-73 246.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89949.1 - 5.2e-36 124.3 0.0 6.5e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI89949.1 - 2.7e-07 30.2 0.0 3.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI89949.1 - 0.0064 15.3 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KPI89949.1 - 0.014 14.4 0.2 0.021 13.8 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KPI89949.1 - 0.086 12.7 0.0 0.18 11.7 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Vps16_N PF04841.13 KPI89950.1 - 3.7e-27 95.1 0.0 1.8e-26 92.9 0.0 2.0 2 0 0 2 2 2 1 Vps16, N-terminal region Vps16_C PF04840.12 KPI89950.1 - 1.8e-26 93.0 0.3 3.5e-15 55.9 0.0 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region Peptidase_C2 PF00648.21 KPI89951.1 - 1.9e-20 73.1 0.0 6.7e-20 71.3 0.0 1.8 1 1 0 1 1 1 1 Calpain family cysteine protease RNA_binding PF01877.17 KPI89952.1 - 0.099 12.9 0.1 0.3 11.4 0.1 1.8 1 0 0 1 1 1 0 RNA binding Hydantoinase_B PF02538.14 KPI89953.1 - 4.8e-197 655.5 1.3 7.4e-197 654.8 1.3 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 KPI89953.1 - 8e-92 307.6 1.4 8e-92 307.6 1.4 2.0 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 KPI89953.1 - 1.1e-51 175.0 0.3 1e-49 168.6 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region PhoD PF09423.10 KPI89954.1 - 2.4e-08 33.4 0.3 0.00025 20.2 0.2 2.7 2 1 0 2 2 2 2 PhoD-like phosphatase Trp_oprn_chp PF09534.10 KPI89955.1 - 0.012 15.5 1.6 0.015 15.1 1.6 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PAP_PilO PF06864.12 KPI89955.1 - 0.016 14.1 0.1 0.018 13.9 0.1 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) TMEM51 PF15345.6 KPI89955.1 - 0.064 13.1 0.1 0.074 12.9 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 HCMV_UL124 PF17609.2 KPI89955.1 - 0.099 12.8 0.6 0.12 12.6 0.6 1.2 1 0 0 1 1 1 0 Family of unknown function COX4 PF02936.14 KPI89955.1 - 0.12 12.4 0.2 10 6.1 0.0 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase subunit IV Robl_LC7 PF03259.17 KPI89957.1 - 4.1e-22 77.8 0.0 4.6e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 KPI89957.1 - 0.013 15.5 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Mito_carr PF00153.27 KPI89958.1 - 4.1e-22 77.9 5.1 5.1e-10 39.1 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein UDPGP PF01704.18 KPI89959.1 - 8.7e-117 390.2 0.0 1.7e-116 389.3 0.0 1.4 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase FUSC PF04632.12 KPI89960.1 - 1.1 7.7 15.8 1.2 7.5 15.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family USP8_interact PF08941.10 KPI89960.1 - 3.1 7.6 8.2 4.4 7.1 6.9 1.8 1 1 1 2 2 2 0 USP8 interacting DUF241 PF03087.14 KPI89960.1 - 3.7 7.3 17.0 0.45 10.3 4.0 2.3 1 1 1 2 2 2 0 Arabidopsis protein of unknown function CEP19 PF14933.6 KPI89960.1 - 7.2 6.9 13.6 23 5.3 13.6 1.9 1 1 0 1 1 1 0 CEP19-like protein IQ PF00612.27 KPI89961.1 - 0.0012 18.5 7.1 1.1 9.3 6.3 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif Mannosyl_trans2 PF04188.13 KPI89962.1 - 3.6e-33 115.5 24.6 3.3e-20 72.8 11.7 4.0 4 0 0 4 4 4 4 Mannosyltransferase (PIG-V) MCLC PF05934.11 KPI89963.1 - 0.1 11.3 2.5 0.14 10.9 2.5 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Nrap_D5 PF17406.2 KPI89964.1 - 3.9e-29 101.5 0.0 8.1e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 KPI89964.1 - 1.7e-16 60.7 0.0 4.8e-16 59.3 0.0 1.8 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D4 PF17405.2 KPI89964.1 - 1e-14 54.5 0.1 2.8e-14 53.0 0.0 1.7 2 0 0 2 2 2 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D2 PF17403.2 KPI89964.1 - 1.2e-07 31.6 0.0 1.2e-05 25.1 0.0 3.0 3 0 0 3 3 3 1 Nrap protein PAP/OAS-like domain Nrap PF03813.14 KPI89964.1 - 0.00069 19.7 0.0 0.7 9.9 0.0 2.4 2 0 0 2 2 2 2 Nrap protein domain 1 Myosin_TH1 PF06017.13 KPI89965.1 - 6.9e-05 22.6 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Halo_GVPC PF05465.13 KPI89965.1 - 0.19 12.0 0.8 0.52 10.6 0.8 1.7 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat FAM184 PF15665.5 KPI89965.1 - 1.1 9.0 14.5 2 8.2 14.5 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B DUF4407 PF14362.6 KPI89965.1 - 3 7.1 10.5 6.1 6.1 10.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 KPI89966.1 - 4.5e-06 27.3 11.5 0.17 12.8 0.6 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89966.1 - 0.0084 16.4 0.9 10 6.5 0.0 4.8 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Laminin_II PF06009.12 KPI89966.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Laminin Domain II Sin_N PF04801.13 KPI89966.1 - 0.19 10.9 0.1 0.28 10.3 0.1 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region PPR_2 PF13041.6 KPI89967.1 - 0.00019 21.6 0.0 0.18 12.0 0.0 3.3 2 1 1 3 3 3 2 PPR repeat family PPR_long PF17177.4 KPI89967.1 - 0.0049 16.2 0.8 0.0049 16.2 0.8 1.9 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 KPI89967.1 - 0.034 14.2 0.0 4.7 7.4 0.0 3.0 2 1 1 3 3 3 0 Pentatricopeptide repeat domain PPR PF01535.20 KPI89967.1 - 0.13 12.6 0.0 17 5.9 0.0 3.6 4 0 0 4 4 4 0 PPR repeat Glyco_trans_1_4 PF13692.6 KPI89968.1 - 9.7e-06 26.0 1.0 6.8e-05 23.3 0.0 2.8 3 1 0 3 3 3 1 Glycosyl transferases group 1 Ras PF00071.22 KPI89969.1 - 4.3e-54 182.5 1.9 3.8e-53 179.4 1.9 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KPI89969.1 - 7.7e-36 122.9 0.1 1.4e-35 122.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI89969.1 - 4.8e-13 48.9 0.0 7.2e-13 48.4 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI89969.1 - 3.4e-07 30.3 0.0 9.5e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KPI89969.1 - 1.3e-06 27.9 0.0 1.5e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KPI89969.1 - 2.9e-05 23.7 0.3 0.00084 18.9 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KPI89969.1 - 0.0039 17.1 0.1 0.079 12.9 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase cobW PF02492.19 KPI89969.1 - 0.0058 16.2 0.1 0.94 9.0 0.0 2.2 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 KPI89969.1 - 0.012 14.8 0.2 0.028 13.6 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain AAA_22 PF13401.6 KPI89969.1 - 0.025 14.9 0.0 0.042 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KPI89969.1 - 0.028 14.1 0.1 0.058 13.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KPI89969.1 - 0.028 14.8 0.2 0.038 14.4 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 KPI89969.1 - 0.038 13.7 0.1 0.078 12.7 0.1 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KPI89969.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 KPI89969.1 - 0.096 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain SRPRB PF09439.10 KPI89969.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 KPI89969.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA PF00004.29 KPI89969.1 - 0.14 12.6 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 KPI89969.1 - 0.16 11.3 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 KPI89969.1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Pro_isomerase PF00160.21 KPI89970.1 - 9e-35 120.3 0.0 1.4e-34 119.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Casc1_N PF15927.5 KPI89970.1 - 4.8 6.8 6.6 0.19 11.4 0.2 1.8 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus ACBP PF00887.19 KPI89972.1 - 0.023 14.9 0.0 0.062 13.5 0.0 1.7 1 0 0 1 1 1 0 Acyl CoA binding protein 14-3-3 PF00244.20 KPI89974.1 - 0.029 13.9 0.2 1.2 8.6 0.0 2.8 3 0 0 3 3 3 0 14-3-3 protein B2 PF11473.8 KPI89974.1 - 0.17 11.7 0.2 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 RNA binding protein B2 WD40 PF00400.32 KPI89975.1 - 8e-24 83.5 19.4 3.2e-07 30.9 0.1 11.2 11 1 1 12 12 12 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI89975.1 - 6.8e-12 45.5 0.0 0.014 15.6 0.0 6.9 6 1 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 KPI89975.1 - 9.8e-12 45.1 0.1 2.3e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF1513 PF07433.11 KPI89975.1 - 0.00068 18.8 1.6 0.11 11.6 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1513) Ge1_WD40 PF16529.5 KPI89975.1 - 0.015 14.3 1.2 0.75 8.7 0.0 3.6 4 1 1 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KPI89975.1 - 0.3 11.1 2.4 67 3.6 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat HEAT_EZ PF13513.6 KPI89976.1 - 3.7e-06 27.3 12.1 1.2 9.7 0.3 7.7 7 0 0 7 7 7 3 HEAT-like repeat HEAT PF02985.22 KPI89976.1 - 0.00059 19.9 10.0 5.2 7.6 0.1 9.0 9 0 0 9 9 9 1 HEAT repeat Vac14_Fab1_bd PF12755.7 KPI89976.1 - 0.14 12.7 0.2 73 4.1 0.0 4.9 6 0 0 6 6 6 0 Vacuolar 14 Fab1-binding region MIEAP PF16026.5 KPI89976.1 - 0.25 11.5 2.3 0.47 10.7 0.3 2.5 3 0 0 3 3 3 0 Mitochondria-eating protein CDP-OH_P_transf PF01066.21 KPI89977.1 - 1.1e-15 58.1 0.0 1.1e-15 58.1 0.0 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Ribosomal_S8 PF00410.19 KPI89978.1 - 1.1e-07 31.9 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 UPF0258 PF06789.12 KPI89978.1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) RNA_pol_Rpb5_C PF01191.19 KPI89979.1 - 2.9e-23 81.5 0.0 8e-23 80.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 KPI89979.1 - 1.1e-07 32.3 0.2 0.00082 19.9 0.0 2.8 2 1 0 2 2 2 2 RNA polymerase Rpb5, N-terminal domain Abhydrolase_4 PF08386.10 KPI89979.1 - 0.04 14.0 0.2 0.12 12.5 0.2 1.8 1 1 1 2 2 2 0 TAP-like protein RNA_pol_Rpb5_C PF01191.19 KPI89980.1 - 1.6e-28 98.3 0.1 3.1e-28 97.4 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 KPI89980.1 - 5.6e-21 74.9 0.0 1.1e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain PDZ_6 PF17820.1 KPI89981.1 - 3.9e-05 23.4 0.1 0.0001 22.1 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KPI89981.1 - 0.026 14.9 0.0 0.076 13.3 0.0 1.8 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 KPI89981.1 - 0.057 13.8 0.1 0.23 11.8 0.1 1.9 1 1 1 2 2 2 0 PDZ domain LysM PF01476.20 KPI89981.1 - 0.14 12.2 0.0 0.4 10.8 0.0 1.8 1 0 0 1 1 1 0 LysM domain eIF3_subunit PF08597.10 KPI89982.1 - 0.00028 20.9 15.8 0.00083 19.3 15.8 1.7 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit KBP_C PF12309.8 KPI89983.1 - 3e-43 148.7 1.2 5.1e-41 141.4 1.2 2.3 1 1 0 1 1 1 1 KIF-1 binding protein C terminal Use1 PF09753.9 KPI89984.1 - 0.0012 18.6 2.2 0.0016 18.2 0.4 1.8 2 0 0 2 2 2 1 Membrane fusion protein Use1 RIFIN PF02009.16 KPI89984.1 - 0.0017 18.3 1.9 0.0024 17.8 1.3 1.4 1 1 0 1 1 1 1 Rifin LMBR1 PF04791.16 KPI89984.1 - 0.017 14.1 0.1 0.021 13.8 0.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2207 PF09972.9 KPI89984.1 - 0.017 13.9 0.0 0.059 12.1 0.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 KPI89984.1 - 0.041 14.2 0.4 0.11 12.8 0.4 1.8 1 0 0 1 1 1 0 Orf78 (ac78) GP41 PF00517.17 KPI89984.1 - 0.049 13.5 1.5 0.075 12.9 0.3 1.8 2 0 0 2 2 2 0 Retroviral envelope protein GP38 PF05268.11 KPI89984.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 Prominin PF05478.11 KPI89984.1 - 0.14 10.1 3.8 0.032 12.2 0.7 1.5 2 0 0 2 2 2 0 Prominin Suppressor_APC PF11414.8 KPI89984.1 - 0.44 10.6 3.5 5.1 7.2 0.2 3.0 2 2 1 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein Uds1 PF15456.6 KPI89984.1 - 5.4 7.2 10.6 88 3.3 9.9 2.2 1 1 0 1 1 1 0 Up-regulated During Septation TPR_2 PF07719.17 KPI89985.1 - 9.6e-21 72.2 21.9 0.00011 22.1 0.8 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 KPI89985.1 - 5.1e-18 64.1 14.9 0.00014 21.5 0.0 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KPI89985.1 - 1.7e-13 49.6 15.6 0.00099 19.1 0.1 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI89985.1 - 3.1e-08 33.8 27.0 4.7e-05 23.6 5.5 5.6 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI89985.1 - 5.9e-08 33.2 28.6 0.0011 19.5 5.7 4.7 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KPI89985.1 - 3.1e-07 30.6 27.4 0.0077 17.0 0.2 6.9 4 2 3 7 7 6 3 Tetratricopeptide repeat zf-C2H2_10 PF16588.5 KPI89985.1 - 5.7e-07 29.1 1.5 1.2e-06 28.1 1.5 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger TPR_9 PF13371.6 KPI89985.1 - 1.2e-06 28.5 8.9 0.00025 21.1 1.6 3.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KPI89985.1 - 1.8e-06 27.9 6.8 0.49 10.9 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI89985.1 - 4e-05 24.0 16.7 0.28 11.7 0.1 4.8 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 KPI89985.1 - 0.00013 22.3 12.6 0.73 10.6 0.0 6.8 5 1 1 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KPI89985.1 - 0.00022 21.2 0.8 0.46 10.6 0.0 3.5 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 KPI89985.1 - 0.00054 19.8 4.5 12 6.2 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KPI89985.1 - 0.0021 17.7 13.0 4.4 7.1 0.1 6.8 4 2 2 6 6 6 1 TPR repeat zf-CCHC PF00098.23 KPI89985.1 - 0.0062 16.6 1.4 0.013 15.5 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle SHNi-TPR PF10516.9 KPI89985.1 - 0.069 12.6 0.2 6.2 6.4 0.0 3.1 3 0 0 3 3 3 0 SHNi-TPR ANAPC3 PF12895.7 KPI89985.1 - 0.088 13.0 18.1 3 8.1 1.0 4.4 3 2 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 V_ATPase_I PF01496.19 KPI89985.1 - 0.095 10.6 0.0 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SMC_ScpA PF02616.14 KPI89985.1 - 0.11 12.4 0.0 0.35 10.8 0.0 1.7 1 1 0 1 1 1 0 Segregation and condensation protein ScpA MAS20 PF02064.15 KPI89985.1 - 0.21 11.7 2.3 0.33 11.1 0.1 2.4 2 1 1 3 3 3 0 MAS20 protein import receptor Sel1 PF08238.12 KPI89985.1 - 0.53 11.1 5.7 5.1 7.9 0.2 4.2 4 1 0 4 4 4 0 Sel1 repeat MIT PF04212.18 KPI89985.1 - 1.9 8.6 15.4 5.9 7.0 0.6 5.0 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain NRBF2_MIT PF17169.4 KPI89985.1 - 5.4 7.3 9.3 1.2 9.4 0.2 3.2 3 1 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 mRNA_triPase PF02940.15 KPI89986.1 - 2.7e-13 50.2 0.0 8.6e-13 48.5 0.0 1.7 1 1 0 1 1 1 1 mRNA capping enzyme, beta chain GTP_EFTU PF00009.27 KPI89988.1 - 6.3e-50 169.4 0.0 9e-50 168.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KPI89988.1 - 2.1e-16 59.7 0.0 5.4e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KPI89988.1 - 1.4e-07 31.8 0.0 3e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 KPI89988.1 - 8.1e-07 28.8 0.0 3.6e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 KPI89988.1 - 0.0022 18.0 0.1 0.0065 16.5 0.0 1.8 2 0 0 2 2 2 1 Elongation Factor G, domain II cobW PF02492.19 KPI89988.1 - 0.17 11.5 0.2 0.4 10.2 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ras PF00071.22 KPI89988.1 - 0.18 11.4 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Ras family Rieske_2 PF13806.6 KPI89989.1 - 3.3e-08 33.4 0.0 5.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 KPI89989.1 - 7.3e-08 32.2 0.3 1.4e-07 31.3 0.3 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Ribonuclease_3 PF00636.26 KPI89989.1 - 0.067 13.8 0.0 0.12 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease III domain NAD_binding_1 PF00175.21 KPI89989.1 - 0.11 13.1 0.0 16 6.2 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain SpoIIE PF07228.12 KPI89990.1 - 2.2e-16 60.4 0.0 1.5e-14 54.3 0.0 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KPI89990.1 - 2.1e-06 27.5 0.1 3.6e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 KPI89990.1 - 0.0021 17.8 0.0 0.0086 15.7 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C SNF2_N PF00176.23 KPI89991.1 - 2.2e-41 141.8 0.4 3.5e-41 141.1 0.4 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI89991.1 - 9.7e-18 64.5 0.0 2.4e-17 63.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI89991.1 - 8.1e-08 32.4 0.0 1.3e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PHD PF00628.29 KPI89991.1 - 4.8e-07 29.6 13.9 0.0012 18.7 1.5 2.8 2 0 0 2 2 2 2 PHD-finger DEAD PF00270.29 KPI89991.1 - 2.7e-06 27.3 0.0 6e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-PHD-like PF15446.6 KPI89991.1 - 0.00066 19.3 7.1 0.2 11.3 0.5 2.7 2 0 0 2 2 2 2 PHD/FYVE-zinc-finger like domain SWI2_SNF2 PF18766.1 KPI89991.1 - 0.0016 18.2 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HDA2-3 PF11496.8 KPI89991.1 - 0.059 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 CDP-OH_P_tran_2 PF08009.11 KPI89992.1 - 0.17 11.8 6.9 0.33 10.9 6.9 1.4 1 0 0 1 1 1 0 CDP-alcohol phosphatidyltransferase 2 CRAL_TRIO PF00650.20 KPI89992.1 - 0.19 11.5 0.5 21 4.8 0.0 2.6 3 0 0 3 3 3 0 CRAL/TRIO domain NIF PF03031.18 KPI89993.1 - 1.3e-46 158.2 0.0 2e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Zeta_toxin PF06414.12 KPI89994.1 - 0.0087 15.4 0.0 2.5 7.4 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin Rad17 PF03215.15 KPI89994.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 KPI89994.1 - 0.013 15.9 0.0 0.023 15.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Cytidylate_kin PF02224.18 KPI89994.1 - 0.014 15.2 1.0 0.052 13.3 0.0 2.3 2 2 0 2 2 2 0 Cytidylate kinase AAA_17 PF13207.6 KPI89994.1 - 0.026 14.9 0.0 0.067 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SapB_1 PF05184.15 KPI89994.1 - 0.038 14.0 0.0 0.19 11.8 0.1 2.3 2 0 0 2 2 2 0 Saposin-like type B, region 1 SRP54 PF00448.22 KPI89994.1 - 0.044 13.4 0.6 0.16 11.6 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Ploopntkinase2 PF18747.1 KPI89994.1 - 0.057 12.7 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase2 AAA_30 PF13604.6 KPI89994.1 - 0.063 13.0 0.6 0.21 11.3 0.0 2.1 3 1 0 3 3 3 0 AAA domain AAA_18 PF13238.6 KPI89994.1 - 0.11 13.0 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KPI89994.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KPI89994.1 - 0.18 11.8 0.4 0.88 9.6 0.0 2.2 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) HpcH_HpaI PF03328.14 KPI89995.1 - 4e-54 183.1 0.0 4.8e-54 182.8 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family rRNA_methylase PF06962.12 KPI89995.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative rRNA methylase Pkinase PF00069.25 KPI89997.1 - 1.9e-59 201.2 0.0 2.6e-43 148.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI89997.1 - 2.8e-33 115.3 0.0 2.1e-24 86.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KPI89997.1 - 4.8e-06 25.6 0.0 1.5e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KPI89997.1 - 0.0022 17.4 0.0 0.26 10.6 0.0 2.6 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 KPI89997.1 - 0.0051 16.8 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KPI89997.1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KPI89997.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DOPA_dioxygen PF08883.11 KPI89998.1 - 0.11 12.7 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 Dopa 4,5-dioxygenase family Kinesin PF00225.23 KPI89999.1 - 1.6e-100 336.3 0.0 2.6e-100 335.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI89999.1 - 1.7e-25 89.7 0.0 3.9e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.6 KPI89999.1 - 0.0012 19.2 0.4 0.24 11.7 0.0 3.3 2 0 0 2 2 2 1 AAA domain DUF982 PF06169.12 KPI89999.1 - 0.078 13.0 0.1 0.28 11.2 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF982) AAA_7 PF12775.7 KPI89999.1 - 0.18 11.3 0.0 0.38 10.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region LUC7 PF03194.15 KPI89999.1 - 1.4 8.5 17.2 0.49 10.0 1.0 2.9 2 1 0 2 2 2 0 LUC7 N_terminus DUF812 PF05667.11 KPI89999.1 - 4.3 6.1 24.9 0.033 13.1 9.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF812) Acylphosphatase PF00708.18 KPI90000.1 - 1.5e-23 83.0 0.0 1.9e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Acylphosphatase Kinesin PF00225.23 KPI90001.1 - 2.5e-77 260.1 3.1 3e-77 259.8 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90001.1 - 3.2e-21 75.8 0.1 1.4e-20 73.8 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding FapA PF03961.13 KPI90001.1 - 0.0034 16.1 1.1 0.0054 15.4 1.1 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A AAA_16 PF13191.6 KPI90001.1 - 1.1 9.6 6.1 2.8 8.3 0.0 3.5 3 1 0 3 3 3 0 AAA ATPase domain DUF4404 PF14357.6 KPI90001.1 - 3 8.6 5.5 7.3 7.3 0.1 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) baeRF_family3 PF18845.1 KPI90002.1 - 0.06 13.6 0.0 33 4.7 0.0 3.4 3 1 1 4 4 4 0 Bacterial archaeo-eukaryotic release factor family 3 RRM_1 PF00076.22 KPI90003.1 - 0.0085 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_12 PF13424.6 KPI90004.1 - 1.6e-08 34.7 30.8 0.00028 21.1 4.1 5.0 1 1 6 7 7 7 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KPI90004.1 - 3.6e-08 33.2 5.6 3.6e-08 33.2 5.6 2.3 2 0 0 2 2 2 1 MalT-like TPR region SNAP PF14938.6 KPI90004.1 - 0.00039 19.9 17.4 0.00042 19.8 5.9 2.9 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KPI90004.1 - 0.0085 16.1 22.2 3.7 7.9 0.1 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat MIT PF04212.18 KPI90004.1 - 0.046 13.8 0.6 0.046 13.8 0.6 3.2 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 KPI90004.1 - 0.046 13.6 13.7 6.6 6.7 0.2 5.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI90004.1 - 0.054 13.6 23.4 0.93 9.7 0.1 6.5 7 1 1 8 8 7 0 Tetratricopeptide repeat DUF3357 PF11837.8 KPI90004.1 - 0.057 13.9 0.5 0.18 12.3 0.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) TPR_14 PF13428.6 KPI90004.1 - 0.065 14.1 29.3 0.49 11.4 3.3 7.2 6 2 0 6 6 6 0 Tetratricopeptide repeat GAS PF13851.6 KPI90004.1 - 0.12 11.7 2.5 1.4 8.2 0.5 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_1 PF00515.28 KPI90004.1 - 0.13 12.1 11.5 25 4.9 0.2 6.0 6 1 0 6 6 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KPI90004.1 - 0.25 11.3 2.6 0.92 9.5 2.6 1.9 1 1 0 1 1 1 0 Mad3/BUB1 homology region 1 ANAPC5 PF12862.7 KPI90004.1 - 0.87 9.7 12.0 1.3 9.2 0.2 3.7 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_4 PF07721.14 KPI90004.1 - 1.3 9.8 22.0 7.8 7.4 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_20 PF14561.6 KPI90004.1 - 3.6 8.0 7.1 1.3 9.4 0.1 3.2 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KPI90004.1 - 9.6 6.0 10.7 9.7 6.0 0.1 4.2 4 0 0 4 4 4 0 TPR repeat DNA_repr_REX1B PF14966.6 KPI90005.1 - 3.1e-05 24.6 0.0 0.012 16.3 0.0 2.4 2 0 0 2 2 2 2 DNA repair REX1-B DFP PF04127.15 KPI90006.1 - 1.6e-21 77.0 0.0 8.2e-11 42.1 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein PAC3 PF10178.9 KPI90007.1 - 0.0012 18.9 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 Vps55 PF04133.14 KPI90008.1 - 9.6e-27 93.3 1.4 1.1e-26 93.1 1.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF308 PF03729.13 KPI90008.1 - 0.062 13.6 8.0 1.8 8.9 1.9 2.3 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) TMEM100 PF16311.5 KPI90008.1 - 0.16 11.6 1.7 0.34 10.5 0.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 100 DUF4999 PF16390.5 KPI90008.1 - 0.16 12.2 0.2 0.7 10.2 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function DUF4576 PF15144.6 KPI90008.1 - 0.26 11.2 0.5 2.1 8.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) DUF4131 PF13567.6 KPI90008.1 - 3.9 7.1 9.5 13 5.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Fn3_assoc PF13287.6 KPI90009.1 - 6.1e-06 26.3 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Fn3 associated CHB_HEX_C_1 PF13290.6 KPI90009.1 - 2.1e-05 24.4 0.0 5.3e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Zwint PF15556.6 KPI90010.1 - 0.024 14.1 4.1 1 8.8 0.5 2.6 3 0 0 3 3 3 0 ZW10 interactor TPM_phosphatase PF04536.14 KPI90011.1 - 3.5e-19 69.2 0.0 5.7e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 TPM domain POTRA_3 PF17287.2 KPI90011.1 - 0.1 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 POTRA domain HMGL-like PF00682.19 KPI90011.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 HMGL-like zf-IS66 PF13005.7 KPI90011.1 - 0.82 10.1 8.6 0.99 9.9 0.0 3.5 3 0 0 3 3 3 0 zinc-finger binding domain of transposase IS66 FYVE_2 PF02318.16 KPI90011.1 - 5 7.4 11.1 16 5.7 11.1 1.9 1 1 0 1 1 1 0 FYVE-type zinc finger WD40 PF00400.32 KPI90012.1 - 1.3e-18 66.9 4.7 3.2e-05 24.6 0.0 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90012.1 - 1.5e-08 34.8 0.0 0.054 13.8 0.0 4.0 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2057 PF09829.9 KPI90012.1 - 0.064 13.4 1.0 0.13 12.5 0.4 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Not3 PF04065.15 KPI90013.1 - 6e-61 205.8 24.4 6e-61 205.8 24.4 1.9 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 KPI90013.1 - 3.9e-34 117.5 10.2 3.9e-34 117.5 10.2 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.6 KPI90013.1 - 0.00024 21.4 1.0 0.00024 21.4 1.0 2.9 3 1 1 4 4 4 1 Syntaxin-like protein SOG2 PF10428.9 KPI90013.1 - 0.0047 16.2 8.7 0.0047 16.2 8.7 2.5 2 1 0 2 2 2 1 RAM signalling pathway protein SLBP_RNA_bind PF15247.6 KPI90014.1 - 5.4e-25 87.3 3.9 1.4e-24 86.0 3.9 1.7 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain Thioredoxin PF00085.20 KPI90016.1 - 0.00093 19.1 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin X PF00739.19 KPI90016.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Trans-activation protein X Zn_ribbon_17 PF17120.5 KPI90017.1 - 0.0046 16.6 16.7 0.0046 16.6 16.7 2.6 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 KPI90017.1 - 0.0083 16.3 14.8 0.66 10.2 0.2 2.7 2 0 0 2 2 2 2 Zinc-ribbon like family CHAP PF05257.16 KPI90018.1 - 0.00013 22.5 0.0 0.00023 21.7 0.0 1.5 1 0 0 1 1 1 1 CHAP domain Dala_Dala_lig_C PF07478.13 KPI90019.1 - 1e-13 51.3 0.0 1.9e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus SET PF00856.28 KPI90019.1 - 2.2e-06 28.2 0.0 2.2e-06 28.2 0.0 2.8 2 1 0 2 2 2 1 SET domain ATP-grasp_3 PF02655.14 KPI90019.1 - 0.0011 19.1 0.0 0.0062 16.6 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 KPI90019.1 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 KPI90019.1 - 0.0041 16.7 0.0 0.0081 15.8 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 KPI90019.1 - 0.021 14.4 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 KPI90019.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Steroid_dh PF02544.16 KPI90020.1 - 1.4e-24 86.8 0.8 2.1e-24 86.2 0.8 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KPI90020.1 - 2.1e-05 24.1 0.7 3.2e-05 23.6 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 KPI90020.1 - 0.052 14.0 3.6 0.2 12.1 0.2 2.4 3 0 0 3 3 3 0 Phospholipid methyltransferase YukD PF08817.10 KPI90020.1 - 0.12 13.1 0.1 0.31 11.8 0.1 1.7 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD RMI1_N PF08585.12 KPI90021.1 - 2.8e-14 53.4 0.0 6.3e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 RecQ mediated genome instability protein Pex14_N PF04695.13 KPI90021.1 - 2.5 8.8 12.0 3.5 8.3 9.3 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1935 PF09149.10 KPI90022.1 - 2e-27 95.6 0.0 2.4e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) GBP_C PF02841.14 KPI90023.1 - 0.12 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Totivirus_coat PF05518.11 KPI90024.1 - 1.1 7.2 5.0 1.5 6.8 5.0 1.1 1 0 0 1 1 1 0 Totivirus coat protein OKR_DC_1_C PF03711.15 KPI90025.1 - 0.15 12.3 0.7 0.43 10.9 0.7 1.7 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain Transket_pyr PF02779.24 KPI90026.1 - 6.5e-47 159.5 0.0 9.6e-47 158.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KPI90026.1 - 2.5e-40 137.2 0.0 4.7e-40 136.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 KPI90026.1 - 0.074 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II LSM PF01423.22 KPI90027.1 - 1.2e-13 50.5 0.0 1.6e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KPI90027.1 - 0.052 13.7 0.3 0.25 11.5 0.3 1.9 1 1 0 1 1 1 0 Ataxin 2 SM domain LSM14 PF12701.7 KPI90027.1 - 0.13 12.4 0.0 2.3 8.4 0.0 2.1 1 1 0 1 1 1 0 Scd6-like Sm domain LRR_9 PF14580.6 KPI90028.1 - 1.9e-11 43.7 0.2 2e-10 40.4 0.1 2.1 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 KPI90028.1 - 3.9e-08 32.9 8.1 8.6e-05 22.2 2.3 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KPI90028.1 - 2.9e-06 27.5 3.4 0.00031 21.1 0.1 3.3 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KPI90028.1 - 0.044 13.9 7.4 0.56 10.4 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 KPI90028.1 - 3.3 8.6 7.1 6.1 7.8 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich Repeat HSCB_C PF07743.13 KPI90029.1 - 0.0049 17.3 4.4 0.024 15.1 0.0 2.9 3 0 0 3 3 3 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 KPI90029.1 - 0.0098 16.0 3.9 0.15 12.2 1.2 2.4 1 1 1 2 2 2 2 DnaJ domain TPR_12 PF13424.6 KPI90030.1 - 8.4e-15 54.8 23.5 1.3e-07 31.7 4.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90030.1 - 2.2e-05 24.2 4.0 0.45 10.7 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KPI90030.1 - 0.012 15.4 0.2 7 6.6 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KPI90030.1 - 0.036 14.7 1.5 24 5.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KPI90030.1 - 0.11 12.8 0.1 11 6.5 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI90030.1 - 2.4 8.4 10.5 1 9.6 0.9 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI90030.1 - 3.2 7.8 11.4 0.84 9.6 1.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat HORMA PF02301.18 KPI90031.1 - 1.3e-18 67.3 0.0 1.7e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 KPI90031.1 - 0.00063 19.6 0.3 0.007 16.2 0.0 2.3 2 1 0 2 2 2 1 Bacterial HORMA domain 2 ATG13 PF10033.9 KPI90031.1 - 0.0013 18.5 0.0 0.0018 18.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 13 ATG101 PF07855.12 KPI90031.1 - 0.035 14.1 0.2 0.42 10.6 0.2 2.0 1 1 0 1 1 1 0 Autophagy-related protein 101 Ala_racemase_N PF01168.20 KPI90031.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain EFP_N PF08207.12 KPI90033.1 - 3.1e-06 27.1 0.6 5.6e-06 26.3 0.6 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain DUF1016_N PF17761.1 KPI90034.1 - 0.0013 18.9 0.1 0.031 14.4 0.0 2.2 2 0 0 2 2 2 1 DUF1016 N-terminal domain ribosomal_L24 PF17136.4 KPI90034.1 - 0.02 15.3 0.1 0.04 14.3 0.1 1.5 1 0 0 1 1 1 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 DUF1697 PF08002.11 KPI90034.1 - 0.12 12.8 2.3 0.99 9.9 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1697) BUD22 PF09073.10 KPI90034.1 - 0.13 11.5 6.8 0.2 11.0 6.8 1.2 1 0 0 1 1 1 0 BUD22 DAGAT PF03982.13 KPI90035.1 - 9.9e-83 277.5 0.0 1.5e-82 276.9 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase JAB PF01398.21 KPI90037.1 - 0.00013 22.0 0.1 0.00053 19.9 0.0 2.0 2 1 1 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.13 KPI90037.1 - 0.017 15.1 0.0 0.066 13.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) WD40 PF00400.32 KPI90038.1 - 1.2e-16 60.8 15.1 0.18 12.7 0.0 9.8 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90038.1 - 1.3e-07 31.8 0.0 0.011 16.0 0.0 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 KPI90038.1 - 0.0036 17.1 0.0 0.0089 15.9 0.0 1.7 1 0 0 1 1 1 1 HELP motif BRCT PF00533.26 KPI90039.1 - 6.8e-06 26.4 0.0 0.0013 19.1 0.0 3.9 3 1 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KPI90039.1 - 0.00012 22.4 0.0 5.4 7.5 0.0 4.3 3 1 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain TRAPPC-Trs85 PF12739.7 KPI90041.1 - 1.5e-36 126.3 0.0 2.5e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Pkinase PF00069.25 KPI90042.1 - 2e-26 93.0 0.0 3.8e-15 56.0 0.0 3.5 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90042.1 - 2.8e-06 26.8 0.0 0.77 9.0 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase RIO1 PF01163.22 KPI90042.1 - 0.023 14.3 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 KPI90042.1 - 0.22 10.4 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase zf-Tim10_DDP PF02953.15 KPI90043.1 - 0.00077 19.1 0.3 0.0012 18.4 0.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Complex1_LYR PF05347.15 KPI90044.1 - 1.7e-05 24.8 0.1 1.7e-05 24.8 0.1 3.2 3 1 0 3 3 3 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KPI90044.1 - 0.076 13.8 0.3 0.076 13.8 0.3 3.3 3 1 1 4 4 4 0 Complex1_LYR-like GN3L_Grn1 PF08701.11 KPI90045.1 - 7.2e-06 26.0 13.6 7.2e-06 26.0 13.6 2.6 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase 6PF2K PF01591.18 KPI90045.1 - 0.11 11.7 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase UVR PF02151.19 KPI90046.1 - 2e-07 30.6 19.4 0.00012 21.7 4.7 2.6 2 0 0 2 2 2 2 UvrB/uvrC motif zf-Di19 PF05605.12 KPI90046.1 - 0.007 16.6 4.4 0.007 16.6 4.4 2.8 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding HEAT PF02985.22 KPI90046.1 - 0.025 14.8 3.1 0.16 12.3 0.1 3.0 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.6 KPI90046.1 - 0.047 14.2 3.2 1.6 9.3 0.1 2.8 2 0 0 2 2 2 0 HEAT-like repeat HEAT_2 PF13646.6 KPI90046.1 - 0.73 10.3 4.0 7.4 7.0 0.0 3.5 3 1 0 3 3 3 0 HEAT repeats zf-C2H2_4 PF13894.6 KPI90046.1 - 1.2 10.2 14.4 0.56 11.2 0.4 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 KPI90046.1 - 2.1 8.9 7.5 1.7 9.2 0.1 3.5 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Kinesin PF00225.23 KPI90047.1 - 8e-102 340.6 0.1 1.7e-101 339.5 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90047.1 - 9.3e-44 149.0 1.7 1.1e-43 148.7 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding VHS PF00790.19 KPI90047.1 - 2e-07 31.0 0.1 1.9e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 VHS domain Dor1 PF04124.12 KPI90047.1 - 0.0012 17.6 1.1 0.0036 16.1 1.1 1.7 1 0 0 1 1 1 1 Dor1-like family TPR_MLP1_2 PF07926.12 KPI90047.1 - 0.0055 16.8 14.9 0.48 10.5 7.3 2.7 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein RAP1 PF07218.11 KPI90047.1 - 0.15 10.3 1.1 0.2 9.9 0.0 1.6 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) HAP1_N PF04849.13 KPI90047.1 - 0.19 10.9 18.1 0.25 10.5 7.5 3.0 3 0 0 3 3 3 0 HAP1 N-terminal conserved region DUF4140 PF13600.6 KPI90047.1 - 0.7 10.4 5.3 3.4 8.2 1.6 2.7 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Gluconate_2-dh3 PF13618.6 KPI90047.1 - 0.93 9.7 7.3 2.2 8.5 0.2 3.9 3 1 0 3 3 3 0 Gluconate 2-dehydrogenase subunit 3 FliD_N PF02465.18 KPI90047.1 - 1.3 9.8 9.1 1.4 9.7 2.2 3.3 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Flu_NS2 PF00601.19 KPI90047.1 - 1.4 9.2 4.6 1.4 9.2 1.5 2.5 2 1 0 2 2 2 0 Influenza non-structural protein (NS2) dsRBD2 PF17842.1 KPI90047.1 - 8.6 6.6 6.8 5.1 7.3 0.0 2.8 3 0 0 3 3 3 0 Double-stranded RNA binding domain 2 DUF5600 PF18150.1 KPI90049.1 - 1.6e-16 60.8 0.5 3.2e-16 59.8 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) Dynamin_N PF00350.23 KPI90049.1 - 5.4e-16 59.1 0.0 1e-14 55.0 0.0 2.2 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KPI90049.1 - 2.1e-07 31.0 0.0 4.3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EHD_N PF16880.5 KPI90049.1 - 0.0056 16.6 0.1 0.014 15.3 0.1 1.6 1 0 0 1 1 1 1 N-terminal EH-domain containing protein RsgA_GTPase PF03193.16 KPI90049.1 - 0.15 11.9 0.0 25 4.8 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase cobW PF02492.19 KPI90049.1 - 0.19 11.3 0.0 7.2 6.2 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF697 PF05128.12 KPI90050.1 - 0.007 16.1 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF697) LEA_6 PF10714.9 KPI90050.1 - 0.018 15.1 2.2 0.1 12.6 0.8 3.0 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 FeoC PF09012.10 KPI90050.1 - 0.05 13.7 0.0 0.49 10.5 0.0 2.4 2 0 0 2 2 2 0 FeoC like transcriptional regulator U-box PF04564.15 KPI90051.1 - 0.0079 16.4 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 KPI90051.1 - 0.0097 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein APG17 PF04108.12 KPI90051.1 - 0.016 14.3 0.2 0.022 13.9 0.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 GAS PF13851.6 KPI90051.1 - 0.029 13.7 2.2 0.055 12.8 2.2 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding zf_CCCH_4 PF18345.1 KPI90051.1 - 6.9 6.9 9.3 0.52 10.4 2.0 2.3 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 KPI90052.1 - 0.0015 18.4 7.0 0.0092 15.9 1.0 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) U-box PF04564.15 KPI90052.1 - 0.0092 16.1 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf_CCCH_4 PF18345.1 KPI90052.1 - 0.017 15.2 10.6 0.11 12.6 2.7 2.5 2 0 0 2 2 2 0 Zinc finger domain zf-NOSIP PF15906.5 KPI90052.1 - 0.022 14.9 0.0 0.056 13.6 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Cep57_CLD_2 PF14197.6 KPI90052.1 - 0.075 13.1 2.0 0.15 12.2 2.0 1.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Med30 PF11315.8 KPI90052.1 - 0.54 10.5 3.1 14 5.8 0.4 2.4 1 1 0 2 2 2 0 Mediator complex subunit 30 UPF0016 PF01169.19 KPI90053.1 - 5.5e-43 145.2 21.5 4.5e-22 78.2 4.0 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 IncD PF17628.2 KPI90053.1 - 1.1 9.0 6.2 3.8 7.3 0.7 2.2 2 0 0 2 2 2 0 Inclusion membrane protein D DUF3796 PF12676.7 KPI90053.1 - 4 7.9 7.4 0.72 10.3 3.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3796) ABC_transp_aux PF09822.9 KPI90054.1 - 2e-06 27.5 0.0 3.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DUF4350 PF14258.6 KPI90054.1 - 0.00091 19.6 0.1 0.0059 17.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4350) HTH_21 PF13276.6 KPI90054.1 - 0.12 12.5 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 HTH-like domain WD40 PF00400.32 KPI90055.1 - 1.2e-14 54.4 12.9 4.7e-05 24.1 0.1 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90055.1 - 0.00012 22.3 0.4 6.7 7.1 0.0 5.6 5 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KPI90055.1 - 0.0063 15.6 0.0 0.018 14.1 0.0 1.7 1 0 0 1 1 1 1 Coatomer WD associated region Tachylectin PF14517.6 KPI90055.1 - 0.13 11.8 1.1 0.67 9.5 0.0 2.6 3 0 0 3 3 3 0 Tachylectin DUF1143 PF06608.11 KPI90056.1 - 0.019 15.0 0.5 2.4 8.2 0.0 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1143) LIAS_N PF16881.5 KPI90057.1 - 2.2e-10 40.9 0.2 6.2e-10 39.5 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 KPI90057.1 - 3.4e-10 40.5 0.0 6.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Pkinase PF00069.25 KPI90058.1 - 1.4e-27 96.7 0.1 6e-16 58.6 0.0 3.9 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90058.1 - 9.5e-05 21.8 0.1 0.57 9.4 0.1 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase WD40 PF00400.32 KPI90060.1 - 2.5e-06 28.1 1.2 0.1 13.5 0.0 5.0 5 0 0 5 5 5 1 WD domain, G-beta repeat PDZ_2 PF13180.6 KPI90060.1 - 0.0002 21.6 0.1 0.00042 20.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Involucrin_N PF10583.9 KPI90060.1 - 0.013 16.1 1.0 0.046 14.3 1.0 1.9 1 0 0 1 1 1 0 Involucrin of squamous epithelia N-terminus PDZ_6 PF17820.1 KPI90060.1 - 0.013 15.3 0.2 0.034 14.0 0.2 1.7 1 0 0 1 1 1 0 PDZ domain Synaptobrevin PF00957.21 KPI90061.1 - 5.6e-12 45.3 0.0 1.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KPI90061.1 - 0.032 14.3 0.0 0.08 13.0 0.0 1.6 2 0 0 2 2 2 0 Regulated-SNARE-like domain UMP1 PF05348.11 KPI90062.1 - 1.7e-06 28.2 0.0 2.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 TFIIS_C PF01096.18 KPI90063.1 - 4.4e-18 64.9 2.7 4.4e-18 64.9 2.7 2.3 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KPI90063.1 - 5.6e-06 26.1 3.0 0.00038 20.3 0.9 2.4 2 0 0 2 2 2 2 RNA polymerases M/15 Kd subunit Baculo_LEF5_C PF11792.8 KPI90063.1 - 0.0036 16.9 0.0 0.0081 15.8 0.0 1.6 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain DUF3560 PF12083.8 KPI90063.1 - 0.025 14.7 0.1 0.037 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3560) Pilosulin PF17499.2 KPI90063.1 - 0.05 13.8 2.5 0.09 13.0 2.5 1.4 1 0 0 1 1 1 0 Ant venom peptides zf-piccolo PF05715.13 KPI90063.1 - 0.057 13.6 2.0 0.26 11.5 0.3 2.4 3 0 0 3 3 3 0 Piccolo Zn-finger Zn_Tnp_IS1595 PF12760.7 KPI90063.1 - 0.075 13.0 3.7 3 7.9 0.1 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_10 PF10058.9 KPI90063.1 - 0.28 11.0 7.3 1.2 8.9 0.7 3.6 3 1 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Lar_restr_allev PF14354.6 KPI90063.1 - 2.8 8.4 10.3 1.5 9.2 0.2 3.0 2 1 0 2 2 2 0 Restriction alleviation protein Lar NAP PF00956.18 KPI90065.1 - 6.7e-63 212.4 1.8 6.7e-63 212.4 1.8 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) BSP_II PF05432.11 KPI90065.1 - 0.0052 16.5 8.9 0.011 15.5 8.9 1.6 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) FRQ PF09421.10 KPI90065.1 - 0.014 13.4 1.3 0.022 12.8 1.3 1.2 1 0 0 1 1 1 0 Frequency clock protein THUMP PF02926.17 KPI90065.1 - 0.066 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 THUMP domain DNA_pol_phi PF04931.13 KPI90065.1 - 2.9 5.9 15.7 1.5 6.8 12.9 1.9 2 0 0 2 2 2 0 DNA polymerase phi SURF2 PF05477.11 KPI90065.1 - 5.7 6.6 8.4 2.4 7.8 5.5 1.8 2 1 0 2 2 2 0 Surfeit locus protein 2 (SURF2) CCDC53 PF10152.9 KPI90067.1 - 2.1e-36 125.7 0.5 2.1e-36 125.7 0.5 2.3 2 1 0 2 2 2 1 Subunit CCDC53 of WASH complex CDC45 PF02724.14 KPI90067.1 - 0.21 9.8 5.5 0.25 9.6 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KPI90067.1 - 2.1 7.0 3.7 2.7 6.6 3.7 1.1 1 0 0 1 1 1 0 Presenilin UPF0193 PF05250.11 KPI90071.1 - 0.052 13.4 3.6 0.063 13.1 3.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0193) AATF-Che1 PF13339.6 KPI90071.1 - 0.064 13.9 0.1 0.13 13.0 0.1 1.5 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor GalP_UDP_transf PF01087.22 KPI90071.1 - 0.099 13.1 0.1 0.15 12.4 0.1 1.2 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, N-terminal domain zf-U11-48K PF05253.12 KPI90071.1 - 0.32 11.0 1.2 0.61 10.1 1.2 1.4 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger CCDC-167 PF15188.6 KPI90071.1 - 0.53 10.7 5.0 0.87 10.0 2.2 2.5 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF659 PF04937.15 KPI90073.1 - 0.12 12.2 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) LRR_4 PF12799.7 KPI90074.1 - 9.5e-09 35.4 1.0 8.6e-05 22.8 0.0 4.1 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI90074.1 - 0.00032 20.4 2.3 0.0052 16.5 0.3 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 KPI90074.1 - 0.032 14.3 2.5 7 7.0 0.1 3.7 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 KPI90074.1 - 0.28 11.9 2.3 80 4.4 0.3 4.3 2 2 0 2 2 2 0 Leucine Rich Repeat Peptidase_M24 PF00557.24 KPI90075.1 - 2.9e-48 164.4 0.0 4e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 KPI90075.1 - 1.6e-15 57.2 8.8 3e-15 56.2 8.8 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 KPI90075.1 - 7.1e-07 29.2 6.1 1.4e-06 28.3 6.1 1.5 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 KPI90075.1 - 0.031 14.2 3.9 0.066 13.1 3.9 1.6 1 0 0 1 1 1 0 HIT zinc finger PHF5 PF03660.14 KPI90075.1 - 0.19 12.0 2.3 0.65 10.2 0.7 2.2 2 0 0 2 2 2 0 PHF5-like protein CH_2 PF06294.11 KPI90076.1 - 9e-17 61.0 0.1 2.5e-16 59.5 0.1 1.9 1 0 0 1 1 1 1 CH-like domain in sperm protein Prominin PF05478.11 KPI90077.1 - 0.00038 18.6 7.5 0.00038 18.6 7.5 2.6 1 1 1 2 2 2 1 Prominin DUF883 PF05957.13 KPI90077.1 - 0.078 13.6 0.0 28 5.4 0.0 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF3094 PF11293.8 KPI90077.1 - 0.34 10.7 2.1 1.6 8.5 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF4179 PF13786.6 KPI90077.1 - 0.61 10.6 3.3 1.1 9.8 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) Neurensin PF14927.6 KPI90077.1 - 6.9 6.4 7.9 12 5.6 0.0 3.4 3 0 0 3 3 3 0 Neurensin Pox_EPC_I2-L1 PF12575.8 KPI90077.1 - 7.9 6.8 9.2 1.8 8.8 0.2 3.2 3 0 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 TBCC PF07986.12 KPI90078.1 - 1.1e-26 92.9 12.8 1e-08 34.9 3.5 3.5 3 0 0 3 3 3 3 Tubulin binding cofactor C Pkinase PF00069.25 KPI90079.1 - 5.7e-44 150.5 0.0 6.2e-34 117.5 0.1 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90079.1 - 1.3e-14 54.2 0.1 1e-12 47.9 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase UPF0242 PF06785.11 KPI90080.1 - 0.022 14.9 0.5 0.038 14.1 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RILP PF11461.8 KPI90080.1 - 0.37 11.1 2.0 0.54 10.5 0.3 2.1 2 0 0 2 2 2 0 Rab interacting lysosomal protein Golgin_A5 PF09787.9 KPI90080.1 - 1.9 7.9 6.2 0.37 10.2 2.1 1.7 2 0 0 2 2 2 0 Golgin subfamily A member 5 ERM PF00769.19 KPI90080.1 - 5.8 6.7 10.4 12 5.6 10.4 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family CYTH PF01928.21 KPI90082.1 - 6.6e-14 52.2 0.3 3.2e-05 23.9 0.0 4.2 4 0 0 4 4 4 4 CYTH domain Histone PF00125.24 KPI90083.1 - 1.2e-38 132.5 3.9 1.4e-38 132.2 3.9 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KPI90083.1 - 2.3e-06 27.8 0.0 2.3e-06 27.8 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 KPI90083.1 - 0.00013 22.0 0.7 0.00018 21.6 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 KPI90083.1 - 0.04 14.0 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 KPI90083.1 - 0.042 14.2 0.0 0.073 13.5 0.0 1.3 1 0 0 1 1 1 0 CENP-S protein SLH PF00395.20 KPI90083.1 - 0.15 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 S-layer homology domain ANF_receptor PF01094.28 KPI90084.1 - 4.2e-37 128.1 3.6 8.6e-29 100.7 0.7 3.3 3 0 0 3 3 3 3 Receptor family ligand binding region Surp PF01805.20 KPI90085.1 - 0.00033 20.6 0.1 0.00086 19.3 0.1 1.7 1 0 0 1 1 1 1 Surp module RNA_pol_A_bac PF01000.26 KPI90086.1 - 7.2e-21 74.7 0.0 1.3e-20 73.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KPI90086.1 - 1.2e-13 50.2 0.0 2e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 KPI90086.1 - 0.032 14.4 1.8 0.064 13.4 1.8 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 KPI90086.1 - 0.053 13.6 2.0 0.12 12.6 2.0 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 KPI90086.1 - 0.11 13.0 1.7 0.28 11.8 1.7 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 KPI90086.1 - 2.7 8.2 4.6 4 7.7 2.9 2.0 2 0 0 2 2 2 0 4Fe-4S binding domain Utp11 PF03998.13 KPI90087.1 - 2.4e-31 109.6 42.9 3.4e-29 102.5 42.9 2.1 1 1 0 1 1 1 1 Utp11 protein Kinesin PF00225.23 KPI90088.1 - 3.9e-31 108.2 0.0 4e-30 104.9 0.0 2.2 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90088.1 - 4.7e-18 65.5 0.0 4.6e-12 46.1 0.0 2.9 3 0 0 3 3 3 2 Microtubule binding PIF1 PF05970.14 KPI90088.1 - 0.14 11.2 0.0 0.35 10.0 0.0 1.5 2 0 0 2 2 2 0 PIF1-like helicase A_deaminase PF00962.22 KPI90089.1 - 2.8e-94 316.1 0.0 1.6e-68 231.4 0.0 2.6 2 1 0 2 2 2 2 Adenosine/AMP deaminase DUF4530 PF15039.6 KPI90089.1 - 0.089 12.9 0.4 0.24 11.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) DUF3301 PF11743.8 KPI90091.1 - 0.44 10.3 2.5 1.1 9.0 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) WD40 PF00400.32 KPI90092.1 - 0.0097 16.8 0.0 46 5.1 0.0 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat CHCH PF06747.13 KPI90093.1 - 0.0026 17.8 3.1 0.0045 17.1 3.1 1.4 1 0 0 1 1 1 1 CHCH domain RuBisCO_small PF00101.20 KPI90093.1 - 0.007 16.3 0.1 0.019 15.0 0.1 1.7 1 1 0 1 1 1 1 Ribulose bisphosphate carboxylase, small chain MTCP1 PF08991.10 KPI90093.1 - 0.013 15.7 1.5 0.019 15.2 1.5 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Complex1_LYR PF05347.15 KPI90096.1 - 0.00037 20.5 1.1 0.0013 18.8 1.1 1.9 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Sod_Fe_C PF02777.18 KPI90097.1 - 1.2e-31 108.9 1.6 1.6e-31 108.5 0.4 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KPI90097.1 - 5.4e-20 71.7 0.2 1.3e-19 70.5 0.2 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Cys_Met_Meta_PP PF01053.20 KPI90098.1 - 2.8e-85 286.2 0.0 3.2e-85 286.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KPI90098.1 - 6e-06 25.7 0.0 9.1e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KPI90098.1 - 0.0023 17.3 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 KPI90098.1 - 0.0072 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KPI90098.1 - 0.091 12.0 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase WW PF00397.26 KPI90099.1 - 1.7e-08 34.4 1.3 3.7e-08 33.3 1.3 1.5 1 0 0 1 1 1 1 WW domain Spc7 PF08317.11 KPI90099.1 - 9.9e-05 21.4 17.6 0.0061 15.5 4.7 2.4 1 1 1 2 2 2 2 Spc7 kinetochore protein DUF3670 PF12419.8 KPI90099.1 - 1.4 8.8 11.6 0.46 10.3 4.4 2.5 2 0 0 2 2 2 0 SNF2 Helicase protein Fmp27_WPPW PF10359.9 KPI90099.1 - 5.2 5.8 10.6 3.3 6.5 2.3 2.3 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain TSC22 PF01166.18 KPI90099.1 - 8.2 6.8 14.8 26 5.2 0.2 4.8 4 1 0 5 5 5 0 TSC-22/dip/bun family SpoU_methylase PF00588.19 KPI90100.1 - 1.2e-23 83.9 0.0 6e-23 81.6 0.0 2.3 2 0 0 2 2 2 1 SpoU rRNA Methylase family Aa_trans PF01490.18 KPI90102.1 - 5.4e-55 186.7 30.2 6.7e-55 186.4 30.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI90102.1 - 8.5e-11 41.5 10.8 8.5e-11 41.5 10.8 1.9 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family DUF4227 PF14004.6 KPI90102.1 - 1.3 9.0 0.0 1.3 9.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4227) DUF1657 PF07870.11 KPI90103.1 - 0.054 13.4 0.9 0.2 11.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1657) VASt PF16016.5 KPI90104.1 - 7e-10 39.5 0.0 1.5e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain Ribosomal_L27e PF01777.18 KPI90105.1 - 1.1e-25 89.7 1.9 1.7e-25 89.2 1.9 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 KPI90105.1 - 2.3e-05 24.2 1.3 3e-05 23.8 0.3 1.8 2 0 0 2 2 2 1 KOW motif Sybindin PF04099.12 KPI90106.1 - 2e-23 82.9 0.0 2.4e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 KPI90106.1 - 7.6e-06 26.1 0.0 8.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Rhodanese PF00581.20 KPI90108.1 - 3.9e-09 37.0 0.0 4.8e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Sec7 PF01369.20 KPI90109.1 - 1.3e-18 67.3 0.0 2.1e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KPI90109.1 - 5.7e-18 65.3 1.9 1.3e-17 64.1 1.9 1.6 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal KKLCAg1 PF15204.6 KPI90109.1 - 0.089 12.9 0.8 0.25 11.5 0.8 1.7 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 DUF4551 PF15087.6 KPI90109.1 - 2.1 7.1 8.1 2.7 6.7 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4551) Rnk_N PF14760.6 KPI90110.1 - 1.1 9.8 4.3 36 4.9 0.6 3.5 2 1 1 3 3 3 0 Rnk N-terminus Memo PF01875.17 KPI90111.1 - 1.9e-23 83.0 0.0 2.5e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein DUF1059 PF06348.11 KPI90111.1 - 1 9.6 5.3 0.2 11.9 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) RNase_T PF00929.24 KPI90114.1 - 1.2e-20 74.7 0.0 9.2e-13 49.1 0.0 2.9 2 1 0 2 2 2 2 Exonuclease DUF5051 PF16473.5 KPI90114.1 - 0.055 13.4 0.0 4.4 7.3 0.0 2.3 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like RRM_1 PF00076.22 KPI90116.1 - 4.1e-22 77.8 0.0 8.2e-09 35.2 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 KPI90116.1 - 0.041 13.7 0.1 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain RPN7 PF10602.9 KPI90117.1 - 3.9e-48 163.4 0.9 4.6e-48 163.2 0.1 1.5 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 KPI90117.1 - 5.9e-16 58.9 0.0 2.3e-15 57.0 0.0 2.0 2 0 0 2 2 2 1 PCI domain NPBW PF15180.6 KPI90118.1 - 0.18 11.7 1.4 0.94 9.3 0.2 2.8 2 0 0 2 2 2 0 Neuropeptides B and W Prefoldin PF02996.17 KPI90119.1 - 2.2e-09 37.3 0.0 2.2e-09 37.3 0.0 2.2 2 1 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.6 KPI90119.1 - 1.3e-05 25.2 3.7 0.019 15.0 0.1 2.6 2 0 0 2 2 2 2 Prefoldin subunit TPR_16 PF13432.6 KPI90120.1 - 3.9e-09 37.0 4.8 9.3e-08 32.6 0.5 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat CS PF04969.16 KPI90120.1 - 4.1e-07 30.9 0.2 1.4e-06 29.2 0.0 2.0 2 0 0 2 2 2 1 CS domain TPR_2 PF07719.17 KPI90120.1 - 3.9e-06 26.6 23.4 0.62 10.3 0.2 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 KPI90120.1 - 4e-06 26.4 18.5 0.12 12.3 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI90120.1 - 0.0025 18.0 10.7 0.21 11.8 0.2 3.9 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KPI90120.1 - 0.0032 17.9 0.1 0.0032 17.9 0.1 4.6 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KPI90120.1 - 0.015 15.2 6.3 0.47 10.4 0.0 4.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI90120.1 - 0.053 14.4 0.1 0.053 14.4 0.1 7.0 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 KPI90120.1 - 0.06 14.0 1.8 1.2 9.9 0.0 3.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KPI90120.1 - 0.26 11.0 5.0 0.17 11.6 0.3 2.9 3 0 0 3 3 3 0 TPR repeat Draxin PF15550.6 KPI90120.1 - 0.72 9.7 6.7 0.21 11.4 2.7 1.9 2 0 0 2 2 2 0 Draxin TPR_12 PF13424.6 KPI90120.1 - 0.97 9.8 0.0 0.97 9.8 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat FYVE PF01363.21 KPI90121.1 - 0.0026 17.9 12.4 0.0061 16.7 12.3 1.7 1 1 0 1 1 1 1 FYVE zinc finger IBR PF01485.21 KPI90121.1 - 0.8 10.0 8.4 2.6 8.4 8.4 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CTP_transf_1 PF01148.20 KPI90122.1 - 4e-31 108.7 19.2 1.5e-30 106.9 1.4 3.8 3 1 0 3 3 3 2 Cytidylyltransferase family Tmemb_161AB PF10268.9 KPI90122.1 - 0.057 12.1 0.1 0.097 11.3 0.1 1.3 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB DUF778 PF05608.12 KPI90123.1 - 4.7e-46 157.5 0.7 8.3e-46 156.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF778) SNAP PF14938.6 KPI90125.1 - 4.7e-55 187.0 21.4 5.4e-55 186.8 21.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 KPI90125.1 - 1.2e-07 31.9 15.5 0.13 13.2 0.1 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KPI90125.1 - 8.4e-06 25.4 11.6 3.7e-05 23.3 8.1 2.1 1 1 1 2 2 2 1 MalT-like TPR region TPR_12 PF13424.6 KPI90125.1 - 2e-05 24.8 13.6 0.0037 17.5 3.6 3.5 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KPI90125.1 - 0.00041 20.8 16.1 0.046 14.2 7.0 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KPI90125.1 - 0.00087 19.3 13.4 0.73 10.2 0.7 5.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90125.1 - 0.0017 18.3 19.9 0.088 13.0 0.8 6.1 6 1 2 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI90125.1 - 0.0056 16.6 11.3 1.6 8.9 0.1 5.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 KPI90125.1 - 0.0077 16.8 19.0 0.85 10.4 0.2 5.2 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 KPI90125.1 - 0.046 14.4 10.9 12 6.9 0.3 5.3 4 1 0 4 4 4 0 Tetratricopeptide repeat Foie-gras_1 PF11817.8 KPI90125.1 - 0.1 12.2 5.4 0.3 10.7 5.3 1.6 1 1 0 1 1 1 0 Foie gras liver health family 1 Pilt PF15453.6 KPI90125.1 - 0.22 10.9 2.4 0.31 10.4 2.4 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions CdiI_2 PF18593.1 KPI90125.1 - 0.23 12.1 2.3 6.8 7.4 0.1 3.1 2 2 2 4 4 3 0 CdiI immunity protein TRAPPC-Trs85 PF12739.7 KPI90125.1 - 0.25 10.3 13.2 0.056 12.4 1.7 3.1 2 1 1 3 3 3 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit RPN7 PF10602.9 KPI90125.1 - 0.28 10.9 11.1 3.3 7.4 2.8 3.4 1 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_11 PF13414.6 KPI90125.1 - 0.43 10.3 10.3 0.95 9.2 1.5 4.6 3 1 2 5 5 5 0 TPR repeat TPR_10 PF13374.6 KPI90125.1 - 0.5 10.3 13.2 14 5.7 0.0 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KPI90125.1 - 0.76 10.5 23.5 6.2 7.6 1.0 4.9 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF2225 PF09986.9 KPI90125.1 - 0.96 9.1 10.4 67 3.1 10.4 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) ANAPC3 PF12895.7 KPI90125.1 - 2 8.7 9.9 1.9 8.8 4.9 3.1 1 1 3 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 AvrM_N PF18247.1 KPI90125.1 - 6.3 6.8 11.6 26 4.9 0.3 4.2 1 1 3 4 4 4 0 Flax-rust effector AvrM N-terminal domain DUF3450 PF11932.8 KPI90126.1 - 0.0039 16.5 2.4 0.0039 16.5 2.4 4.5 3 1 1 5 5 5 2 Protein of unknown function (DUF3450) Atg14 PF10186.9 KPI90126.1 - 0.063 12.4 0.1 0.063 12.4 0.1 4.0 3 1 1 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF802 PF05650.11 KPI90126.1 - 2.1 8.9 10.2 4.8 7.7 1.6 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF802) UCH PF00443.29 KPI90127.1 - 3.8e-49 167.5 0.0 5.9e-49 166.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI90127.1 - 1.6e-10 41.1 10.5 1.2e-07 31.6 0.1 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KPI90127.1 - 0.0046 17.5 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 DUSP domain VCBS PF13517.6 KPI90128.1 - 0.039 14.5 1.0 0.68 10.6 0.5 3.0 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF4247 PF14042.6 KPI90128.1 - 0.055 14.1 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4247) FG-GAP PF01839.23 KPI90128.1 - 0.39 10.9 3.7 0.34 11.1 0.5 2.7 3 0 0 3 3 3 0 FG-GAP repeat TTL PF03133.15 KPI90129.1 - 7.4e-53 179.6 0.0 1.9e-39 135.6 0.0 2.2 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KPI90129.1 - 1.1e-08 34.7 0.0 0.00051 19.4 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp DUF1738 PF08401.11 KPI90130.1 - 5.3e-06 26.6 0.0 0.36 10.9 0.0 3.3 3 0 0 3 3 3 3 Domain of unknown function (DUF1738) NDK PF00334.19 KPI90131.1 - 5.8e-56 188.2 0.0 6.6e-56 188.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase MCM PF00493.23 KPI90132.1 - 6.7e-96 319.7 0.0 9.7e-96 319.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KPI90132.1 - 1.1e-25 90.0 1.5 2.1e-25 89.0 1.5 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KPI90132.1 - 2.5e-21 75.9 0.1 5.9e-21 74.7 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 KPI90132.1 - 5.6e-07 29.6 0.1 2.5e-06 27.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KPI90132.1 - 7.6e-07 28.7 0.0 0.00015 21.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_lid_2 PF17863.1 KPI90132.1 - 0.0014 18.4 1.3 0.0033 17.2 1.3 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 KPI90132.1 - 0.011 15.6 0.0 0.038 13.8 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 KPI90132.1 - 0.033 14.6 0.4 0.29 11.6 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KPI90132.1 - 0.051 13.3 0.0 0.47 10.1 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 KPI90132.1 - 0.12 12.8 0.5 4 7.8 0.0 2.9 1 1 0 2 2 2 0 AAA ATPase domain TBCA PF02970.16 KPI90133.1 - 2.1e-16 60.0 4.2 3.2e-16 59.4 4.2 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A TSC22 PF01166.18 KPI90133.1 - 0.0026 18.0 0.8 0.006 16.9 0.8 1.7 1 0 0 1 1 1 1 TSC-22/dip/bun family Fib_alpha PF08702.10 KPI90133.1 - 0.031 14.5 2.1 0.039 14.1 2.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DrrA_P4M PF14860.6 KPI90133.1 - 0.071 13.0 1.1 0.088 12.7 1.1 1.1 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain YabA PF06156.13 KPI90133.1 - 0.099 13.3 1.6 0.14 12.8 0.9 1.6 1 1 1 2 2 2 0 Initiation control protein YabA TMF_DNA_bd PF12329.8 KPI90133.1 - 2.6 8.1 9.5 0.49 10.4 3.1 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Thioredoxin PF00085.20 KPI90134.1 - 1.3e-06 28.4 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 KPI90134.1 - 2e-06 27.0 0.1 2.3e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 Phosducin TraF PF13728.6 KPI90134.1 - 0.0012 18.7 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 KPI90134.1 - 0.075 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_6 PF13848.6 KPI90134.1 - 0.1 12.5 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain KaiB PF07689.12 KPI90134.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 KaiB domain Nt_Gln_amidase PF09764.9 KPI90135.1 - 1.5e-29 102.9 0.3 3e-29 102.0 0.3 1.5 1 1 0 1 1 1 1 N-terminal glutamine amidase Gln_deamidase_2 PF18626.1 KPI90135.1 - 0.063 13.5 0.0 0.094 13.0 0.0 1.3 1 0 0 1 1 1 0 Glutaminase Rab5ip PF07019.12 KPI90137.1 - 1.5e-19 70.4 8.8 1.7e-19 70.1 8.8 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF21 PF01595.20 KPI90138.1 - 2.5e-32 112.0 2.0 4.1e-32 111.3 2.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain TAF4 PF05236.14 KPI90138.1 - 0.41 10.4 4.1 0.61 9.8 4.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF21 PF01595.20 KPI90139.1 - 2.8e-32 111.8 5.8 4.8e-32 111.1 5.8 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain LRR_4 PF12799.7 KPI90140.1 - 4.2e-15 55.6 11.3 3e-08 33.8 3.0 3.7 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) AMPK1_CBM PF16561.5 KPI90140.1 - 2.3e-14 53.4 0.0 1.3e-13 51.0 0.0 2.1 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase LRR_9 PF14580.6 KPI90140.1 - 8.2e-12 45.0 0.1 4.5e-06 26.3 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KPI90140.1 - 2.9e-08 33.3 9.3 0.0011 18.7 2.6 3.5 2 1 1 3 3 3 3 Leucine rich repeat SCAB-Ig PF16709.5 KPI90140.1 - 6.9e-08 32.5 0.2 1.2 9.2 0.0 4.7 3 1 1 4 4 4 3 Ig domain of plant-specific actin-binding protein LRR_6 PF13516.6 KPI90140.1 - 0.0015 18.5 8.9 3.1 8.1 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat CBM_48 PF02922.18 KPI90140.1 - 0.063 13.6 0.0 0.52 10.7 0.0 2.3 2 0 0 2 2 2 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) RicinB_lectin_2 PF14200.6 KPI90140.1 - 0.073 13.8 0.0 32 5.4 0.0 2.7 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like LRR_1 PF00560.33 KPI90140.1 - 0.16 12.6 8.4 70 4.6 0.3 5.3 5 1 0 5 5 5 0 Leucine Rich Repeat SOG2 PF10428.9 KPI90140.1 - 0.92 8.6 11.6 1.4 8.1 11.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MMR_HSR1 PF01926.23 KPI90141.1 - 6.1e-12 45.6 0.0 1.2e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KPI90141.1 - 2.7e-05 24.2 0.0 0.00081 19.3 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KPI90141.1 - 0.026 14.0 0.0 9.7 5.7 0.0 2.6 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KPI90141.1 - 0.051 13.1 0.0 0.097 12.2 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B DnaJ PF00226.31 KPI90142.1 - 4.1e-21 74.9 0.0 1.3e-20 73.2 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain Metallophos PF00149.28 KPI90143.1 - 3.1e-36 125.8 0.0 4.2e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KPI90143.1 - 0.0033 17.9 0.1 0.007 16.8 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Roc PF08477.13 KPI90144.1 - 7.8e-14 51.9 0.0 1.5e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KPI90144.1 - 9.4e-11 41.6 0.0 2.2e-10 40.4 0.0 1.5 1 1 0 1 1 1 1 Ras family COR PF16095.5 KPI90144.1 - 6.5e-09 35.9 0.0 2e-07 31.1 0.0 2.3 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Gtr1_RagA PF04670.12 KPI90144.1 - 0.00059 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region IBR PF01485.21 KPI90144.1 - 0.0018 18.4 0.4 0.0039 17.4 0.4 1.5 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zf-MIZ PF02891.20 KPI90147.1 - 5.3e-09 35.7 8.0 1.5e-08 34.2 8.0 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KPI90147.1 - 8.1e-06 25.6 2.9 1.9e-05 24.4 2.9 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS91 PF14319.6 KPI90147.1 - 0.14 12.3 0.2 0.14 12.3 0.2 2.1 2 0 0 2 2 2 0 Transposase zinc-binding domain ABC_tran PF00005.27 KPI90148.1 - 4.9e-34 117.8 0.0 9e-34 116.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KPI90148.1 - 5.4e-31 108.3 5.7 7.2e-31 107.8 5.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KPI90148.1 - 0.00018 21.0 0.2 0.013 15.0 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KPI90148.1 - 0.00069 20.0 0.1 0.0021 18.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KPI90148.1 - 0.0054 16.6 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KPI90148.1 - 0.062 13.1 0.6 0.19 11.5 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KPI90148.1 - 0.078 13.2 0.1 0.33 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KPI90148.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 KPI90148.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 KPI90148.1 - 0.14 12.7 0.0 0.22 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain DivIC PF04977.15 KPI90150.1 - 0.0074 16.0 8.9 0.026 14.3 1.0 2.7 1 1 1 2 2 2 2 Septum formation initiator THP2 PF09432.10 KPI90150.1 - 0.24 11.5 3.5 1.4 9.0 2.7 2.3 1 1 1 2 2 2 0 Tho complex subunit THP2 DUF4164 PF13747.6 KPI90150.1 - 1.2 9.5 15.1 1.5 9.1 5.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) FSH1 PF03959.13 KPI90151.1 - 2.3e-31 109.1 0.0 4.9e-31 108.0 0.0 1.6 2 0 0 2 2 2 1 Serine hydrolase (FSH1) MMR_HSR1_C PF08438.10 KPI90151.1 - 6.8e-23 81.4 0.0 1.8e-22 80.0 0.0 1.8 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 KPI90151.1 - 1.4e-15 57.4 0.0 3.1e-08 33.7 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI90151.1 - 0.00026 20.6 0.2 0.0049 16.4 0.0 2.6 3 0 0 3 3 3 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KPI90151.1 - 0.0066 16.3 0.0 0.31 10.8 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RWD PF05773.22 KPI90151.1 - 0.0091 16.3 0.0 0.051 13.9 0.0 2.1 2 0 0 2 2 2 1 RWD domain Hydrolase_4 PF12146.8 KPI90151.1 - 0.013 14.7 0.1 0.22 10.8 0.0 2.7 3 0 0 3 3 3 0 Serine aminopeptidase, S33 FliD_C PF07195.12 KPI90151.1 - 0.07 12.5 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus PseudoU_synth_2 PF00849.22 KPI90153.1 - 2.3e-19 70.0 0.0 2e-11 44.2 0.0 2.4 2 0 0 2 2 2 2 RNA pseudouridylate synthase mRNA_cap_enzyme PF01331.19 KPI90154.1 - 0.023 14.5 0.5 0.041 13.7 0.5 1.4 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain FlaC_arch PF05377.11 KPI90154.1 - 0.091 13.2 2.3 2.8 8.4 0.0 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DASH_Duo1 PF08651.10 KPI90154.1 - 0.13 12.0 0.2 0.13 12.0 0.2 2.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 Sec34 PF04136.15 KPI90154.1 - 0.16 11.8 11.0 3.3 7.6 0.1 3.4 3 0 0 3 3 3 0 Sec34-like family DUF1664 PF07889.12 KPI90154.1 - 1.4 9.0 8.1 3.9 7.5 0.1 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 KPI90154.1 - 5.2 7.2 29.9 3.3 7.8 6.1 3.6 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein TEX13 PF15186.6 KPI90154.1 - 6.9 6.3 18.6 0.19 11.4 10.1 2.7 2 1 1 3 3 3 0 Testis-expressed sequence 13 protein family MSG PF02349.15 KPI90154.1 - 7.1 6.9 8.1 3.6 7.9 3.4 2.5 2 0 0 2 2 2 0 Major surface glycoprotein BILBO1_N PF18281.1 KPI90155.1 - 1.3e-15 57.6 0.0 2.6e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 BILBO1 N-terminal domain zf-C2H2_2 PF12756.7 KPI90156.1 - 4.1e-16 59.2 8.2 9.1e-11 42.0 3.4 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Ribosomal_60s PF00428.19 KPI90156.1 - 0.028 15.0 2.0 0.065 13.8 2.0 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Actin_micro PF17003.5 KPI90156.1 - 0.64 9.1 2.5 2.4 7.2 2.4 2.0 1 1 0 1 1 1 0 Putative actin-like family Auto_anti-p27 PF06677.12 KPI90156.1 - 1.1 9.4 0.0 1.1 9.4 0.0 3.2 4 0 0 4 4 4 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) PC_rep PF01851.22 KPI90158.1 - 0.12 12.9 7.7 18 6.0 0.0 5.1 6 0 0 6 6 6 0 Proteasome/cyclosome repeat IFT20 PF14931.6 KPI90159.1 - 3.7e-34 117.4 5.8 4.2e-34 117.3 5.8 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 RE_AlwI PF09491.10 KPI90159.1 - 0.0067 15.3 0.8 0.0075 15.1 0.8 1.1 1 0 0 1 1 1 1 AlwI restriction endonuclease DUF459 PF04311.13 KPI90159.1 - 0.059 12.4 0.0 0.072 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF459) ISG65-75 PF11727.8 KPI90159.1 - 0.14 11.4 2.2 0.16 11.1 2.2 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Mannosyl_trans PF05007.13 KPI90161.1 - 3.6e-81 272.8 15.8 5.3e-81 272.3 15.8 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) GT87 PF09594.10 KPI90161.1 - 3.4e-09 36.8 15.9 3.4e-09 36.8 15.9 2.9 2 1 1 3 3 3 1 Glycosyltransferase family 87 PIG-U PF06728.13 KPI90161.1 - 1.3e-07 31.0 18.8 4.6e-07 29.2 18.6 1.8 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U ASC PF00858.24 KPI90162.1 - 1.6 7.6 11.3 5 6.0 1.2 3.0 2 1 1 3 3 3 0 Amiloride-sensitive sodium channel Peptidase_C2 PF00648.21 KPI90163.1 - 1.1e-27 96.9 1.0 2.9e-12 46.2 0.0 4.1 4 0 0 4 4 4 3 Calpain family cysteine protease LRR_6 PF13516.6 KPI90163.1 - 0.00081 19.3 0.0 0.3 11.3 0.1 2.9 2 0 0 2 2 2 1 Leucine Rich repeat LRR_1 PF00560.33 KPI90163.1 - 0.017 15.6 0.8 23 6.1 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 KPI90163.1 - 0.042 14.3 2.6 4.6 7.8 0.1 2.7 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) Calpain_III PF01067.22 KPI90163.1 - 0.052 13.8 0.0 4.2 7.6 0.0 3.1 3 0 0 3 3 3 0 Calpain large subunit, domain III LRR_8 PF13855.6 KPI90163.1 - 0.25 11.1 1.0 35 4.3 0.1 3.0 2 1 0 2 2 2 0 Leucine rich repeat Ebola_NP PF05505.12 KPI90164.1 - 0.0035 15.7 0.0 0.0038 15.6 0.0 1.1 1 0 0 1 1 1 1 Ebola nucleoprotein DAO PF01266.24 KPI90165.1 - 2.3e-36 126.1 0.0 3.5e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KPI90165.1 - 0.048 14.2 0.2 0.12 12.9 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NFACT-R_1 PF05670.13 KPI90168.1 - 5.8e-44 149.2 0.0 9.1e-44 148.6 0.0 1.3 1 0 0 1 1 1 1 NFACT protein RNA binding domain FTO_NTD PF12933.7 KPI90168.1 - 0.044 13.0 2.0 0.039 13.2 1.1 1.4 2 0 0 2 2 2 0 FTO catalytic domain NACHT PF05729.12 KPI90169.1 - 0.0036 17.3 0.1 0.0093 15.9 0.1 1.7 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 KPI90169.1 - 0.0067 16.7 0.0 0.028 14.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KPI90169.1 - 0.032 14.6 0.1 0.13 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain ATP-synt_ab PF00006.25 KPI90169.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.6 KPI90169.1 - 0.14 12.5 0.1 0.68 10.3 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 KPI90169.1 - 0.16 11.7 0.2 0.52 10.0 0.2 1.8 1 1 0 1 1 1 0 AAA domain Fe-ADH PF00465.19 KPI90171.1 - 1.3e-107 359.8 0.0 1.5e-107 359.6 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 KPI90171.1 - 5.9e-18 65.5 0.0 9.2e-11 41.9 0.0 2.1 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DUF1670 PF07900.11 KPI90171.1 - 0.21 10.9 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) DHQ_synthase PF01761.20 KPI90171.1 - 0.28 10.3 1.3 4.3 6.4 0.0 2.8 2 1 1 3 3 3 0 3-dehydroquinate synthase PMEI PF04043.15 KPI90172.1 - 0.0053 17.1 0.7 2.4 8.5 0.0 2.5 2 0 0 2 2 2 2 Plant invertase/pectin methylesterase inhibitor Apolipoprotein PF01442.18 KPI90172.1 - 0.011 15.6 2.3 0.021 14.7 2.3 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain COG5 PF10392.9 KPI90172.1 - 0.02 15.1 0.3 0.045 13.9 0.3 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF1664 PF07889.12 KPI90172.1 - 0.022 14.8 1.2 0.047 13.7 1.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 KPI90172.1 - 0.04 13.5 0.3 0.065 12.8 0.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 KPI90172.1 - 0.34 11.4 1.6 3.1 8.3 1.6 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein RsfS PF02410.15 KPI90174.1 - 2.6e-13 50.3 0.3 4.7e-13 49.4 0.3 1.5 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Pkinase PF00069.25 KPI90175.1 - 9.2e-51 172.7 0.1 5.8e-38 130.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90175.1 - 6.1e-35 120.8 0.0 2.6e-28 99.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Beta_helix PF13229.6 KPI90175.1 - 1.5e-29 102.9 7.3 6.9e-18 65.0 0.1 3.3 2 1 1 3 3 3 2 Right handed beta helix region NosD PF05048.13 KPI90175.1 - 1.5e-24 86.6 0.6 1.2e-13 50.9 0.4 2.6 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) Kinase-like PF14531.6 KPI90175.1 - 1.6e-05 24.4 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like zf-B_box PF00643.24 KPI90175.1 - 0.00049 20.2 8.0 0.0013 18.9 8.0 1.7 1 0 0 1 1 1 1 B-box zinc finger DUF1565 PF07602.11 KPI90175.1 - 0.003 16.9 5.0 0.71 9.2 2.3 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1565) Kdo PF06293.14 KPI90175.1 - 0.0098 15.3 0.5 0.95 8.8 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KPI90175.1 - 0.03 14.3 0.0 0.088 12.7 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family IBR PF01485.21 KPI90175.1 - 0.037 14.2 5.3 0.11 12.7 5.3 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CEBP_ZZ PF16366.5 KPI90175.1 - 0.058 13.6 8.4 0.2 11.9 8.4 1.9 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Zf_RING PF16744.5 KPI90175.1 - 0.14 12.3 3.1 0.47 10.6 3.1 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger Patatin PF01734.22 KPI90176.1 - 1.6e-21 77.4 0.0 3.5e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3336 PF11815.8 KPI90176.1 - 6e-08 32.5 0.0 1.1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) WD40 PF00400.32 KPI90177.1 - 2.1e-11 44.2 1.8 0.002 18.9 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90177.1 - 8.8e-09 35.6 0.1 0.0076 16.5 0.0 5.2 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI90177.1 - 0.14 10.8 1.5 2.8 6.5 0.0 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Frtz PF11768.8 KPI90177.1 - 0.24 9.7 0.0 23 3.2 0.1 2.8 2 1 2 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz DMRT-like PF15791.5 KPI90178.1 - 0.015 15.7 0.9 0.048 14.1 0.9 1.8 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 IBR PF01485.21 KPI90179.1 - 1.5e-14 53.9 25.6 1.2e-09 38.3 4.3 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 KPI90179.1 - 0.00025 20.9 11.4 0.00025 20.9 11.4 3.9 3 0 0 3 3 3 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KPI90179.1 - 0.013 15.3 7.3 0.013 15.3 7.3 4.8 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KPI90179.1 - 0.019 15.3 12.3 0.019 15.3 12.3 4.0 3 0 0 3 3 3 0 Ring finger domain RRM_1 PF00076.22 KPI90180.1 - 1.1e-24 86.0 0.0 1.1e-14 54.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KPI90180.1 - 0.01 15.9 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif RRM_1 PF00076.22 KPI90181.1 - 8e-22 76.8 0.9 5.8e-14 51.7 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI90181.1 - 0.074 13.2 0.0 1.4 9.0 0.0 2.9 3 2 0 3 3 3 0 RNA recognition motif RRM_Rrp7 PF17799.1 KPI90181.1 - 0.12 12.2 0.0 0.45 10.3 0.0 1.8 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain DUF2129 PF09902.9 KPI90181.1 - 0.17 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2129) zf-CCCH PF00642.24 KPI90182.1 - 0.017 15.1 5.2 0.029 14.3 5.2 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KPI90182.1 - 0.14 12.0 8.5 0.25 11.2 8.5 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI90182.1 - 3.9 7.7 8.9 8.3 6.6 8.9 1.6 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 KPI90183.1 - 4.1e-05 23.4 3.7 6e-05 22.8 3.7 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KPI90183.1 - 5.1e-05 23.0 4.5 7.5e-05 22.4 4.5 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 KPI90183.1 - 0.0021 18.5 2.4 0.0035 17.8 2.4 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Orthopox_F8 PF05886.11 KPI90183.1 - 0.024 14.7 1.1 0.054 13.6 1.1 1.6 1 0 0 1 1 1 0 Orthopoxvirus F8 protein zf-CCCH PF00642.24 KPI90184.1 - 6.8e-07 29.0 0.7 1e-06 28.5 0.7 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KPI90184.1 - 1.6e-05 24.6 0.9 2.4e-05 24.0 0.9 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI90184.1 - 0.00099 19.1 0.5 0.008 16.2 0.5 2.2 1 1 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 KPI90184.1 - 0.0088 16.5 0.8 0.016 15.7 0.8 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KPI90184.1 - 0.036 14.3 0.2 0.06 13.6 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger containing family GYF_2 PF14237.6 KPI90185.1 - 8.4e-18 63.9 0.2 2.4e-17 62.5 0.2 1.9 1 0 0 1 1 1 1 GYF domain 2 DnaJ PF00226.31 KPI90185.1 - 1.3e-10 41.2 0.1 4.5e-10 39.5 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain CDC14 PF08045.11 KPI90185.1 - 0.14 11.3 0.3 0.32 10.0 0.3 1.5 1 0 0 1 1 1 0 Cell division control protein 14, SIN component DUF155 PF02582.14 KPI90186.1 - 1.6e-17 64.2 0.1 3.7e-17 63.0 0.1 1.7 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Mito_carr PF00153.27 KPI90189.1 - 1.7e-09 37.4 9.3 0.22 11.4 0.0 5.3 4 1 0 4 4 4 4 Mitochondrial carrier protein PIR PF00399.19 KPI90189.1 - 0.19 11.4 1.0 0.36 10.4 1.0 1.5 1 0 0 1 1 1 0 Yeast PIR protein repeat CytB6-F_Fe-S PF08802.10 KPI90189.1 - 0.27 11.3 3.7 0.31 11.1 0.5 2.4 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit zf-C2H2_2 PF12756.7 KPI90190.1 - 4.1e-26 91.3 8.3 9.4e-20 70.8 1.1 3.2 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KPI90190.1 - 3.2e-10 40.0 5.1 1.2e-06 28.6 0.1 3.9 3 1 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KPI90190.1 - 1.6e-06 28.4 11.0 0.0018 18.9 0.8 4.3 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.7 KPI90190.1 - 2.6e-06 27.6 11.9 0.00018 21.8 1.1 3.7 3 1 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KPI90190.1 - 5e-06 26.4 6.2 0.0029 17.6 0.9 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KPI90190.1 - 0.00012 22.3 16.7 0.014 15.8 1.5 4.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_12 PF18658.1 KPI90190.1 - 0.011 15.3 12.7 0.026 14.1 0.1 4.3 4 1 1 5 5 5 0 Zinc-finger C2H2-type HalOD2 PF18547.1 KPI90190.1 - 0.083 12.8 2.8 0.12 12.3 0.1 2.5 3 0 0 3 3 3 0 Halobacterial output domain 2 zf-C2H2_9 PF16293.5 KPI90190.1 - 0.097 12.5 1.7 37 4.3 0.0 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) OTT_1508_deam PF14441.6 KPI90190.1 - 0.21 11.6 1.2 4 7.5 0.0 3.2 4 0 0 4 4 4 0 OTT_1508-like deaminase zf-LYAR PF08790.11 KPI90190.1 - 0.52 10.3 3.8 0.2 11.6 0.5 2.1 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-FCS PF06467.14 KPI90190.1 - 0.6 10.1 2.8 2.8 8.0 0.2 2.9 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif DUF4574 PF15141.6 KPI90190.1 - 0.67 9.9 3.6 1 9.3 1.7 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 zf-H2C2_2 PF13465.6 KPI90190.1 - 0.82 10.2 4.5 5.2 7.7 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger double domain DUF2509 PF10713.9 KPI90190.1 - 1.5 8.9 5.2 17 5.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2509) TF_Zn_Ribbon PF08271.12 KPI90190.1 - 2.5 7.7 6.9 0.28 10.7 0.2 2.6 3 0 0 3 3 2 0 TFIIB zinc-binding zf_C2H2_ZHX PF18387.1 KPI90190.1 - 4.8 6.9 15.3 4.2 7.1 0.0 4.7 6 0 0 6 6 5 0 Zinc-fingers and homeoboxes C2H2 finger domain PhoLip_ATPase_C PF16212.5 KPI90191.1 - 1.4e-40 139.7 16.3 1.4e-40 139.7 16.3 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KPI90191.1 - 1e-16 60.4 5.2 1e-16 60.4 5.2 1.9 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KPI90191.1 - 2.2e-10 41.2 0.6 0.00013 22.4 0.9 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KPI90191.1 - 5.8e-06 26.3 0.0 1.8e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KPI90191.1 - 0.0014 18.2 0.2 0.0085 15.6 0.2 2.2 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KPI90191.1 - 0.0036 17.1 0.1 0.0093 15.7 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4646 PF15496.6 KPI90191.1 - 0.055 14.1 0.0 0.2 12.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4646) LRR_4 PF12799.7 KPI90193.1 - 1.3e-16 60.4 18.3 0.00098 19.5 0.7 7.9 6 2 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI90193.1 - 2.7e-14 52.6 19.9 9.6e-06 25.3 0.4 5.6 6 0 0 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 KPI90193.1 - 2.1e-05 24.1 3.4 0.16 11.4 0.0 4.3 2 1 3 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.6 KPI90193.1 - 3.1 8.1 20.7 7.9 6.8 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich repeat TTL PF03133.15 KPI90194.1 - 1.7e-46 158.7 0.0 3.8e-27 95.2 0.0 3.1 2 1 1 3 3 3 3 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KPI90194.1 - 6.2e-07 28.9 0.0 0.025 13.9 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KPI90194.1 - 1.7e-06 27.5 0.0 0.046 13.0 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 KPI90194.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus DEAD PF00270.29 KPI90195.1 - 1.3e-12 47.9 0.0 3.2e-12 46.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI90195.1 - 6.4e-12 45.8 0.0 2.7e-11 43.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ground-like PF04155.18 KPI90196.1 - 0.02 15.5 0.3 0.056 14.1 0.3 1.7 1 0 0 1 1 1 0 Ground-like domain RF3_C PF16658.5 KPI90196.1 - 0.054 13.3 0.0 0.19 11.6 0.0 1.9 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain PUA_3 PF17785.1 KPI90197.1 - 0.03 14.1 0.0 0.085 12.7 0.0 1.7 1 0 0 1 1 1 0 PUA-like domain SET PF00856.28 KPI90198.1 - 2.6e-10 40.9 0.0 6e-10 39.8 0.0 1.5 1 1 0 1 1 1 1 SET domain F-protein PF00469.20 KPI90199.1 - 0.21 11.2 1.8 0.2 11.2 0.7 1.5 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef MRPL52 PF18699.1 KPI90199.1 - 1.7 8.9 7.6 4 7.7 7.6 1.6 1 0 0 1 1 1 0 Mitoribosomal protein mL52 DUF1682 PF07946.14 KPI90199.1 - 2.5 7.2 12.2 10 5.2 10.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) zf-C2H2_4 PF13894.6 KPI90200.1 - 0.36 11.8 1.7 1.1 10.3 1.7 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger Pyridoxal_deC PF00282.19 KPI90201.1 - 1.5e-12 47.0 0.0 2.9e-12 46.0 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KPI90201.1 - 3.7e-09 36.0 0.0 1.8e-08 33.8 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KPI90201.1 - 0.067 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family zf-C3HC4_4 PF15227.6 KPI90202.1 - 1e-10 41.6 7.3 1e-10 41.6 7.3 3.8 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KPI90202.1 - 6.7e-10 38.7 6.0 6.7e-10 38.7 6.0 3.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI90202.1 - 2.8e-09 36.7 6.8 2.8e-09 36.7 6.8 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI90202.1 - 1.6e-08 34.4 5.0 1.6e-08 34.4 5.0 2.7 3 0 0 3 3 3 1 RING-type zinc-finger zf-B_box PF00643.24 KPI90202.1 - 1.8e-07 31.2 39.1 6.6e-06 26.2 11.1 4.0 4 0 0 4 4 4 2 B-box zinc finger zf-RING_5 PF14634.6 KPI90202.1 - 5.7e-07 29.4 7.1 5.7e-07 29.4 7.1 3.5 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 KPI90202.1 - 6.1e-07 29.7 6.4 6.1e-07 29.7 6.4 3.5 3 0 0 3 3 3 1 Ring finger domain POTRA_3 PF17287.2 KPI90202.1 - 8.3 6.0 6.2 3 7.4 1.1 2.4 2 0 0 2 2 2 0 POTRA domain Arf PF00025.21 KPI90203.1 - 1.4e-49 167.9 0.0 1.6e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KPI90203.1 - 7.4e-19 67.9 0.0 9e-19 67.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KPI90203.1 - 4.6e-11 42.8 0.0 6e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 KPI90203.1 - 2.6e-10 40.1 0.0 3.4e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KPI90203.1 - 4.3e-10 39.3 0.0 5.5e-06 25.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KPI90203.1 - 4.5e-10 39.8 0.0 6.1e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KPI90203.1 - 4.5e-05 22.9 0.0 6.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KPI90203.1 - 9.3e-05 22.0 0.0 0.00019 21.0 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_25 PF13481.6 KPI90203.1 - 0.0045 16.6 0.0 0.0075 15.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain NOG1 PF06858.14 KPI90203.1 - 0.016 15.0 0.2 0.041 13.7 0.2 1.7 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) MeaB PF03308.16 KPI90203.1 - 0.019 14.0 0.0 0.17 10.9 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 KPI90203.1 - 0.02 14.3 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_18 PF13238.6 KPI90203.1 - 0.021 15.4 0.0 0.046 14.3 0.0 1.6 1 1 1 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 KPI90203.1 - 0.028 14.3 0.0 5.1 7.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase CdhD PF03599.16 KPI90203.1 - 0.054 12.2 0.0 0.071 11.8 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit MMR_HSR1_Xtn PF16897.5 KPI90203.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain cobW PF02492.19 KPI90203.1 - 0.13 11.8 0.2 6.2 6.4 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATG16 PF08614.11 KPI90204.1 - 0.0032 17.7 9.2 0.0032 17.7 9.2 2.7 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) WDCP PF15390.6 KPI90204.1 - 1.6 7.0 14.2 2.5 6.4 2.9 2.1 1 1 0 2 2 2 0 WD repeat and coiled-coil-containing protein family Fmp27_WPPW PF10359.9 KPI90204.1 - 2.3 7.0 14.1 1 8.1 5.9 2.2 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF3450 PF11932.8 KPI90204.1 - 3.9 6.7 31.8 0.016 14.5 5.4 3.6 2 1 0 3 3 3 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 KPI90204.1 - 9.7 5.0 32.0 0.12 11.3 2.2 3.0 2 1 1 3 3 3 0 Spc7 kinetochore protein Filament PF00038.21 KPI90206.1 - 5.7e-05 22.9 21.0 5.7e-05 22.9 21.0 4.0 2 1 2 4 4 4 2 Intermediate filament protein TMF_TATA_bd PF12325.8 KPI90206.1 - 0.00066 19.9 4.9 0.00066 19.9 4.9 6.5 4 1 2 6 6 6 3 TATA element modulatory factor 1 TATA binding Cnn_1N PF07989.11 KPI90206.1 - 0.0034 17.5 1.7 0.0034 17.5 1.7 6.5 4 3 1 5 5 5 1 Centrosomin N-terminal motif 1 KxDL PF10241.9 KPI90206.1 - 0.21 11.9 20.5 0.84 10.0 5.6 4.3 3 1 1 4 4 4 0 Uncharacterized conserved protein TPR_MLP1_2 PF07926.12 KPI90206.1 - 0.53 10.3 67.4 0.63 10.1 2.7 6.7 3 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein UCH_C PF18031.1 KPI90206.1 - 6.2 6.8 8.2 5.1 7.1 0.1 3.8 3 0 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolases IFP_35_N PF07334.13 KPI90206.1 - 8.5 6.5 10.2 13 5.9 0.5 4.6 4 1 0 4 4 4 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus His_Phos_1 PF00300.22 KPI90207.1 - 1e-08 35.1 0.7 4.8e-05 23.1 0.0 3.7 2 1 2 4 4 4 2 Histidine phosphatase superfamily (branch 1) Sec63 PF02889.16 KPI90208.1 - 3.4e-141 468.8 3.1 1e-79 267.4 0.7 2.6 3 0 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.29 KPI90208.1 - 6.2e-53 179.2 0.0 9.9e-28 97.1 0.1 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 KPI90208.1 - 2.4e-27 96.0 0.0 4.2e-16 59.4 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI90208.1 - 1.1e-15 58.0 0.0 2.7e-07 30.9 0.0 3.8 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 KPI90208.1 - 1.1e-09 38.3 0.0 0.00016 21.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KPI90208.1 - 2.1e-07 31.4 0.4 0.0012 19.2 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 KPI90208.1 - 1.4e-05 25.4 0.3 0.016 15.5 0.0 3.5 3 2 0 3 3 2 1 AAA domain T2SSE PF00437.20 KPI90208.1 - 0.00039 19.6 0.0 0.58 9.2 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein PhoH PF02562.16 KPI90208.1 - 0.00066 19.2 0.1 0.18 11.2 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein SWI2_SNF2 PF18766.1 KPI90208.1 - 0.00066 19.4 0.1 0.069 12.8 0.1 2.3 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 KPI90208.1 - 0.0013 18.0 0.1 0.0059 15.9 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.23 KPI90208.1 - 0.0021 16.9 0.3 0.011 14.4 0.2 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain IstB_IS21 PF01695.17 KPI90208.1 - 0.0052 16.5 0.2 11 5.6 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_7 PF12775.7 KPI90208.1 - 0.011 15.2 0.1 1.3 8.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 KPI90208.1 - 0.023 14.1 0.2 1.5 8.2 0.0 3.4 3 0 0 3 3 3 0 Bacterial TniB protein UvrD-helicase PF00580.21 KPI90208.1 - 0.091 12.3 0.0 2.8 7.4 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 KPI90208.1 - 0.092 13.2 0.8 7.9 6.9 0.1 3.7 3 2 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Ccdc124 PF06244.12 KPI90210.1 - 7.5e-20 71.8 15.3 1.1e-18 68.0 15.3 2.6 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 KPI90210.1 - 0.063 13.7 0.0 0.063 13.7 0.0 3.2 2 1 2 4 4 4 0 HMG (high mobility group) box DUF4407 PF14362.6 KPI90210.1 - 0.64 9.3 11.2 0.91 8.8 11.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3807 PF12720.7 KPI90210.1 - 0.92 9.7 18.7 1.7 8.9 18.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Dus PF01207.17 KPI90212.1 - 0.043 12.9 0.0 0.065 12.3 0.0 1.2 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) DUF179 PF02622.15 KPI90213.1 - 6.9e-20 71.6 0.0 1.4e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 dsrm PF00035.26 KPI90214.1 - 0.023 15.4 0.0 0.57 10.9 0.0 2.7 2 0 0 2 2 2 0 Double-stranded RNA binding motif Ribosomal_L4 PF00573.22 KPI90215.1 - 0.51 10.0 3.1 1.5 8.5 2.5 1.9 2 0 0 2 2 2 0 Ribosomal protein L4/L1 family DUF667 PF05018.13 KPI90216.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF667) PARG_cat PF05028.14 KPI90217.1 - 9.8e-86 288.1 0.0 1.3e-85 287.7 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Tctex-1 PF03645.13 KPI90218.1 - 4.2e-26 91.2 0.0 4.9e-26 91.0 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family SpoU_methylase PF00588.19 KPI90220.1 - 2e-07 31.3 0.0 4.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family Sybindin PF04099.12 KPI90221.1 - 1.8e-20 73.3 0.1 2.1e-20 73.1 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family CHU_C PF13585.6 KPI90221.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 C-terminal domain of CHU protein family Pkinase PF00069.25 KPI90222.1 - 6.4e-08 32.3 0.0 0.00047 19.6 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90222.1 - 4e-05 23.0 0.0 0.016 14.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Alb1 PF09135.11 KPI90223.1 - 4.5e-05 24.3 15.1 4.5e-05 24.3 15.1 2.1 1 1 1 2 2 2 1 Alb1 DIT1_PvcA PF05141.12 KPI90223.1 - 0.17 11.4 8.4 0.22 10.9 8.4 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Rx_N PF18052.1 KPI90223.1 - 3.2 8.1 9.3 7.7 6.9 1.6 2.5 1 1 1 2 2 2 0 Rx N-terminal domain Leo1 PF04004.13 KPI90224.1 - 3.1e-10 40.2 0.2 1.2e-09 38.2 0.0 1.8 1 1 0 1 1 1 1 Leo1-like protein Aminotran_5 PF00266.19 KPI90225.1 - 1.4e-45 155.8 0.1 3.8e-44 151.2 0.1 2.2 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KPI90225.1 - 0.00088 18.6 0.1 0.0015 17.9 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KPI90225.1 - 0.05 12.8 0.0 0.18 11.0 0.0 1.8 1 1 0 1 1 1 0 Aminotransferase class I and II MFS_1 PF07690.16 KPI90228.1 - 2.2e-23 82.8 40.9 5.8e-21 74.8 14.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Pam17 PF08566.10 KPI90228.1 - 5.9 6.7 6.0 0.53 10.1 0.2 2.3 3 1 0 3 3 3 0 Mitochondrial import protein Pam17 DUF818 PF05677.12 KPI90229.1 - 8.8e-12 44.6 0.0 1.2e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Hydrolase_4 PF12146.8 KPI90229.1 - 4.8e-08 32.6 0.0 7.7e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KPI90229.1 - 1.1e-06 29.4 0.0 2.6e-06 28.2 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KPI90229.1 - 9.4e-06 25.5 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KPI90229.1 - 0.00071 19.1 0.0 0.0016 18.0 0.0 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family LIDHydrolase PF10230.9 KPI90229.1 - 0.006 16.2 0.2 0.014 14.9 0.0 1.7 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 KPI90229.1 - 0.0072 16.2 0.0 0.035 14.0 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF1188 PF06690.11 KPI90229.1 - 0.01 15.4 0.2 0.089 12.3 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1188) Lipase_3 PF01764.25 KPI90229.1 - 0.019 14.9 0.1 0.044 13.7 0.0 1.6 2 0 0 2 2 1 0 Lipase (class 3) UPF0227 PF05728.12 KPI90229.1 - 0.022 14.7 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF2974 PF11187.8 KPI90229.1 - 0.027 14.0 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF1749 PF08538.10 KPI90229.1 - 0.035 13.2 0.1 0.21 10.6 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1749) Abhydrolase_5 PF12695.7 KPI90229.1 - 0.036 13.8 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family PAF-AH_p_II PF03403.13 KPI90229.1 - 0.12 10.9 0.0 0.23 9.9 0.0 1.5 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Thioesterase PF00975.20 KPI90229.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain Peptidase_S15 PF02129.18 KPI90229.1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) MFS_1 PF07690.16 KPI90230.1 - 3.6e-22 78.8 31.0 3.6e-22 78.8 31.0 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KPI90230.1 - 6.6e-08 31.8 11.6 3.8e-07 29.3 8.3 2.9 2 1 0 2 2 2 1 MFS_1 like family Ctr PF04145.15 KPI90230.1 - 0.12 13.0 1.2 0.46 11.1 0.0 2.5 4 0 0 4 4 4 0 Ctr copper transporter family Corona_S2 PF01601.16 KPI90231.1 - 1.3 7.4 5.6 2 6.8 5.6 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein HCMV_UL124 PF17609.2 KPI90232.1 - 0.0054 16.9 1.1 0.0095 16.1 0.9 1.5 1 1 0 1 1 1 1 Family of unknown function S1FA PF04689.13 KPI90232.1 - 0.21 11.8 0.1 0.39 10.9 0.1 1.4 1 0 0 1 1 1 0 DNA binding protein S1FA MFS_1 PF07690.16 KPI90233.1 - 6.9e-18 64.7 41.7 2.4e-17 62.9 38.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily IQ PF00612.27 KPI90234.1 - 0.00017 21.1 2.1 0.0005 19.6 2.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif MMR_HSR1 PF01926.23 KPI90235.1 - 1.3e-06 28.4 0.0 2.4e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI90235.1 - 0.004 16.7 0.0 0.02 14.4 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.6 KPI90235.1 - 0.015 15.7 0.2 0.065 13.6 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 KPI90235.1 - 0.016 14.7 0.0 0.11 12.0 0.0 2.2 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KPI90235.1 - 0.049 13.0 0.0 0.087 12.2 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KPI90235.1 - 0.19 11.1 0.0 0.51 9.8 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit GalKase_gal_bdg PF10509.9 KPI90238.1 - 2.3e-16 59.1 0.0 5.7e-16 57.8 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 KPI90238.1 - 2.2e-08 34.4 0.1 1.9e-07 31.4 0.0 2.4 2 0 0 2 2 2 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KPI90238.1 - 1e-06 28.9 0.1 2e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain MFS_1 PF07690.16 KPI90239.1 - 2e-09 36.9 38.1 2e-09 36.9 38.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Acyl-CoA_dh_1 PF00441.24 KPI90240.1 - 2.1e-41 141.6 2.2 3.1e-41 141.1 2.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KPI90240.1 - 6.7e-26 90.3 0.0 1.5e-25 89.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 KPI90240.1 - 2.7e-25 89.2 0.0 6.3e-25 88.0 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 KPI90240.1 - 1.1e-20 74.2 0.0 1.8e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SET PF00856.28 KPI90241.1 - 0.15 12.4 0.0 0.66 10.3 0.0 2.1 1 1 0 1 1 1 0 SET domain SNARE PF05739.19 KPI90242.1 - 2.5e-13 49.8 0.3 8.3e-13 48.1 0.3 2.0 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 KPI90242.1 - 7.4e-06 25.8 16.7 1.2e-05 25.1 16.7 1.3 1 0 0 1 1 1 1 Syntaxin MCU PF04678.13 KPI90242.1 - 0.022 14.8 1.3 0.022 14.8 1.3 2.3 2 1 0 2 2 2 0 Mitochondrial calcium uniporter Syntaxin-5_N PF11416.8 KPI90242.1 - 0.16 11.2 0.5 0.42 9.9 0.5 1.6 1 0 0 1 1 1 0 Syntaxin-5 N-terminal, Sly1p-binding domain CemA PF03040.14 KPI90242.1 - 1.5 8.7 9.2 0.37 10.7 3.2 2.1 2 0 0 2 2 2 0 CemA family NDUF_B7 PF05676.13 KPI90243.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) TRAPPC9-Trs120 PF08626.11 KPI90244.1 - 0.00025 18.6 0.0 0.0026 15.2 0.0 2.1 2 0 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit BTB_2 PF02214.22 KPI90245.1 - 6.5e-10 39.2 0.0 1.7e-09 37.9 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain GCIP PF13324.6 KPI90245.1 - 0.012 15.2 0.2 0.017 14.7 0.2 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting HSBP1 PF06825.12 KPI90246.1 - 2e-26 91.6 4.8 2.4e-26 91.3 4.8 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Erythro-docking PF09277.11 KPI90246.1 - 0.001 18.9 0.3 0.0049 16.7 0.3 1.9 1 1 1 2 2 2 1 Erythronolide synthase, docking EspB PF05802.11 KPI90246.1 - 0.0081 16.2 0.1 0.0091 16.0 0.1 1.1 1 0 0 1 1 1 1 Enterobacterial EspB protein RTX PF02382.15 KPI90246.1 - 0.026 14.2 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 N-terminal domain in RTX protein BLOC1_2 PF10046.9 KPI90246.1 - 0.029 14.6 0.1 0.043 14.1 0.1 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CLZ PF16526.5 KPI90246.1 - 0.056 13.8 0.0 0.086 13.2 0.0 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ank_2 PF12796.7 KPI90247.1 - 2.1e-20 73.1 0.3 5.3e-14 52.6 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KPI90247.1 - 5.6e-20 70.8 1.7 5.6e-10 39.2 0.0 4.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 KPI90247.1 - 4e-19 66.7 0.5 1.3e-05 25.2 0.0 4.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 KPI90247.1 - 2.2e-17 63.1 2.5 2.2e-10 40.8 0.2 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KPI90247.1 - 2.7e-13 49.9 0.9 5e-08 33.1 0.2 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) RhoGEF67_u1 PF16615.5 KPI90248.1 - 0.057 13.9 0.4 0.057 13.9 0.4 5.6 7 1 0 7 7 7 0 Unstructured region one on RhoGEF 6 and 7 Asp-B-Hydro_N PF05279.11 KPI90248.1 - 2.3 8.2 12.8 0.053 13.6 4.9 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Rotamase_2 PF13145.6 KPI90248.1 - 9.6 7.1 11.5 12 6.8 3.3 3.2 2 1 1 3 3 3 0 PPIC-type PPIASE domain zf-HC5HC2H PF13771.6 KPI90251.1 - 5.5e-05 23.3 9.6 5.5e-05 23.3 9.6 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KPI90251.1 - 0.0016 18.6 10.9 0.0016 18.6 10.9 2.5 2 1 0 2 2 2 1 PHD-zinc-finger like domain NIF PF03031.18 KPI90252.1 - 3.8e-29 101.5 0.4 6.4e-29 100.7 0.4 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 KPI90252.1 - 0.11 12.9 0.2 4.4 7.7 0.0 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DUF3583 PF12126.8 KPI90252.1 - 0.63 9.4 6.6 0.44 9.9 5.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3583) PRIMA1 PF16101.5 KPI90253.1 - 4 7.5 8.4 0.61 10.1 2.6 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF4106 PF13388.6 KPI90253.1 - 4 6.6 5.9 5 6.3 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Y_phosphatase3 PF13350.6 KPI90254.1 - 8.7e-56 189.5 0.0 9.8e-56 189.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 KPI90254.1 - 0.0096 15.5 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KPI90254.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI90254.1 - 0.27 10.8 0.0 0.37 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DHHC PF01529.20 KPI90255.1 - 7.3e-27 94.1 2.9 7.3e-27 94.1 2.9 2.2 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF3325 PF11804.8 KPI90256.1 - 0.088 13.0 0.9 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) Cortex-I_coil PF09304.10 KPI90257.1 - 0.051 13.8 0.6 0.12 12.7 0.6 1.6 1 0 0 1 1 1 0 Cortexillin I, coiled coil FAD_binding_1 PF00667.20 KPI90258.1 - 7.6e-31 107.4 0.0 1.6e-30 106.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KPI90258.1 - 1.6e-17 64.0 0.5 1.4e-12 48.0 0.0 2.8 3 0 0 3 3 3 2 Flavodoxin FAD_binding_6 PF00970.24 KPI90258.1 - 0.00053 20.3 0.0 0.0078 16.6 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain RRM_1 PF00076.22 KPI90259.1 - 1.4e-25 88.8 0.0 2.6e-14 52.8 0.0 3.6 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI90259.1 - 5.6e-08 32.8 0.1 0.0034 17.5 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif MRP-S31 PF15433.6 KPI90259.1 - 0.0032 17.2 4.2 0.0032 17.2 4.2 1.8 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S31 RRM_Rrp7 PF17799.1 KPI90259.1 - 0.023 14.5 0.0 3.5 7.4 0.0 2.3 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Spo7_2_N PF15407.6 KPI90259.1 - 0.094 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Sporulation protein family 7 DUF1360 PF07098.11 KPI90260.1 - 0.0049 16.8 0.3 0.086 12.8 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1360) DUF5310 PF17237.2 KPI90260.1 - 0.013 15.3 1.1 0.049 13.5 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5310) Claudin_2 PF13903.6 KPI90261.1 - 0.69 9.6 6.1 1.3 8.7 6.1 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF2207 PF09972.9 KPI90261.1 - 7.5 5.2 5.5 55 2.3 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3694 PF12473.8 KPI90262.1 - 0.087 13.5 0.3 0.4 11.3 0.0 2.0 2 0 0 2 2 2 0 Kinesin protein zf-RING_2 PF13639.6 KPI90263.1 - 5.9e-12 45.7 17.6 2.1e-06 27.9 3.5 3.9 3 1 0 3 3 3 2 Ring finger domain zf-RING_11 PF17123.5 KPI90263.1 - 5.5e-09 35.6 22.8 1.7e-05 24.4 4.6 3.8 4 0 0 4 4 3 2 RING-like zinc finger zf-RING_UBOX PF13445.6 KPI90263.1 - 2.9e-07 30.4 18.7 0.002 18.1 0.7 4.9 5 0 0 5 5 5 2 RING-type zinc-finger zf-RING_5 PF14634.6 KPI90263.1 - 8.4e-07 28.9 22.3 8.2e-05 22.5 4.5 4.1 3 2 0 3 3 3 2 zinc-RING finger domain IQ PF00612.27 KPI90263.1 - 1.6e-05 24.2 1.1 8.2e-05 22.1 1.1 2.3 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-C3HC4 PF00097.25 KPI90263.1 - 0.0058 16.5 17.6 0.35 10.8 0.4 4.5 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KPI90263.1 - 0.0084 15.9 20.1 5.5 6.9 7.5 5.6 4 1 0 4 4 4 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KPI90263.1 - 0.0096 15.8 21.3 0.89 9.4 0.2 5.1 5 0 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KPI90263.1 - 0.017 15.4 23.4 0.054 13.8 0.5 5.0 4 1 0 4 4 4 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 KPI90263.1 - 0.019 14.6 11.6 0.043 13.4 1.5 3.6 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type zf-C2H2_3 PF13878.6 KPI90263.1 - 0.14 12.0 1.3 1.8 8.5 0.0 3.1 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO Zf_RING PF16744.5 KPI90263.1 - 0.64 10.2 11.2 1.9 8.7 4.8 3.7 3 1 0 3 3 3 0 KIAA1045 RING finger zf-ANAPC11 PF12861.7 KPI90263.1 - 1.4 9.0 17.6 17 5.5 3.7 4.3 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 KPI90263.1 - 2.2 8.3 16.0 0.12 12.4 0.5 4.8 5 0 0 5 5 5 0 Prokaryotic RING finger family 1 zf-C3HC4_3 PF13920.6 KPI90263.1 - 7.7 6.5 23.9 31 4.5 0.5 5.2 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) DUF3584 PF12128.8 KPI90265.1 - 0.0042 14.7 15.1 0.0065 14.1 15.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF5343 PF17278.2 KPI90265.1 - 0.04 14.0 0.0 0.24 11.5 0.0 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5343) Fib_alpha PF08702.10 KPI90265.1 - 0.27 11.4 2.6 0.36 11.0 0.7 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FPP PF05911.11 KPI90265.1 - 1.5 6.9 15.6 3.4 5.7 9.4 2.2 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil Fez1 PF06818.15 KPI90265.1 - 4.4 7.7 13.1 11 6.5 13.1 1.6 1 0 0 1 1 1 0 Fez1 APG6_N PF17675.1 KPI90265.1 - 5.3 7.6 27.4 0.12 12.9 0.8 3.1 3 0 0 3 3 3 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 KPI90265.1 - 6 6.9 20.8 7.1 6.7 0.6 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nop53 PF07767.11 KPI90266.1 - 3.3e-18 66.3 22.1 4.3e-18 65.9 22.1 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) WTX PF09422.10 KPI90266.1 - 0.14 11.2 9.3 0.18 10.8 9.3 1.1 1 0 0 1 1 1 0 WTX protein PTPlike_phytase PF14566.6 KPI90266.1 - 0.43 10.7 2.9 0.82 9.8 2.9 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Ribosomal_L37 PF08561.10 KPI90266.1 - 0.96 10.0 21.7 15 6.1 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 RR_TM4-6 PF06459.12 KPI90266.1 - 2.9 7.6 16.3 4.1 7.2 16.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRP7 PF12923.7 KPI90267.1 - 6.4e-06 26.3 3.2 6.4e-06 26.3 3.2 2.8 2 1 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF3492 PF11997.8 KPI90267.1 - 0.28 10.9 0.1 0.28 10.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) HECT PF00632.25 KPI90268.1 - 1.4e-75 254.7 0.0 1.5e-74 251.3 0.0 2.1 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) C1_2 PF03107.16 KPI90268.1 - 0.0018 18.5 8.2 0.0018 18.5 8.2 2.5 2 0 0 2 2 2 1 C1 domain IBR PF01485.21 KPI90268.1 - 0.2 11.9 2.1 0.65 10.3 2.1 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-B_box PF00643.24 KPI90268.1 - 0.53 10.5 4.1 2.1 8.6 4.1 2.1 1 0 0 1 1 1 0 B-box zinc finger DUF2703 PF10865.8 KPI90268.1 - 0.6 10.3 2.7 1.8 8.7 2.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) ZZ PF00569.17 KPI90268.1 - 0.61 9.9 11.4 0.11 12.3 7.2 1.9 2 0 0 2 2 2 0 Zinc finger, ZZ type C1_1 PF00130.22 KPI90268.1 - 9.7 6.2 10.1 0.22 11.5 2.1 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FAA_hydrolase PF01557.18 KPI90269.1 - 2e-44 151.8 0.2 2.2e-42 145.2 0.2 2.0 1 1 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Rbx_binding PF18113.1 KPI90269.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain Peptidase_M8 PF01457.16 KPI90271.1 - 2.9e-48 164.9 1.3 4.5e-28 98.2 0.1 4.6 3 2 0 3 3 3 3 Leishmanolysin Vps5 PF09325.10 KPI90272.1 - 2.8e-17 63.1 3.3 3.8e-17 62.6 3.3 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 KPI90272.1 - 3.3e-17 62.5 0.1 1e-16 60.9 0.0 1.8 2 0 0 2 2 2 1 PX domain End3 PF12761.7 KPI90272.1 - 0.03 14.5 0.9 0.23 11.6 1.0 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF4164 PF13747.6 KPI90272.1 - 0.15 12.4 2.4 0.33 11.2 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) UCH PF00443.29 KPI90273.1 - 4.7e-36 124.6 0.0 7.9e-35 120.6 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI90273.1 - 5.7e-12 45.9 0.0 8.8e-10 38.7 0.0 3.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 KPI90274.1 - 1.6e-05 25.1 0.0 0.52 10.6 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI90274.1 - 0.00021 22.0 4.3 0.76 10.7 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Mcp5_PH PF12814.7 KPI90274.1 - 0.14 12.2 0.0 0.42 10.7 0.0 1.7 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Spt4 PF06093.13 KPI90275.1 - 1e-09 38.3 0.0 1.8e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger SET PF00856.28 KPI90277.1 - 0.00062 20.2 0.0 0.02 15.3 0.0 2.9 2 1 0 2 2 2 1 SET domain DUF1764 PF08576.10 KPI90278.1 - 3.2e-09 37.6 6.6 6.5e-08 33.4 0.5 2.5 3 0 0 3 3 3 2 Eukaryotic protein of unknown function (DUF1764) Peptidase_M24 PF00557.24 KPI90279.1 - 2.6e-52 177.6 0.7 4.2e-52 176.9 0.7 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KPI90279.1 - 9.7e-23 80.2 0.0 2.3e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain UDPG_MGDP_dh PF00984.19 KPI90279.1 - 0.016 15.4 0.0 0.054 13.7 0.0 1.9 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain EGF PF00008.27 KPI90279.1 - 0.16 12.3 2.9 0.35 11.2 2.9 1.6 1 0 0 1 1 1 0 EGF-like domain CAF1 PF04857.20 KPI90280.1 - 6.7e-49 166.8 0.0 1.5e-48 165.7 0.0 1.6 1 1 0 1 1 1 1 CAF1 family ribonuclease Peptidase_C10 PF01640.17 KPI90280.1 - 0.046 14.0 0.1 0.098 13.0 0.1 1.5 1 0 0 1 1 1 0 Peptidase C10 family HEAT_EZ PF13513.6 KPI90281.1 - 1.1e-09 38.6 8.6 0.00013 22.3 0.0 7.2 6 1 1 7 7 7 2 HEAT-like repeat HEAT PF02985.22 KPI90281.1 - 2.9e-09 36.4 7.8 0.00017 21.6 0.2 7.0 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 KPI90281.1 - 8.7e-05 22.8 0.1 0.033 14.6 0.0 3.8 3 0 0 3 3 3 1 HEAT repeats IBN_N PF03810.19 KPI90281.1 - 0.00085 19.2 0.7 0.0036 17.2 0.3 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Adaptin_N PF01602.20 KPI90281.1 - 0.0034 16.0 0.2 0.037 12.6 0.0 2.5 2 0 0 2 2 2 1 Adaptin N terminal region Arm PF00514.23 KPI90281.1 - 0.0051 16.8 1.1 11 6.2 0.1 4.7 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Tti2 PF10521.9 KPI90281.1 - 0.022 14.3 0.0 11 5.5 0.0 3.4 2 1 1 3 3 3 0 Tti2 family Cnd1 PF12717.7 KPI90281.1 - 0.029 14.4 0.0 9.7 6.2 0.0 3.2 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 KPI90281.1 - 0.036 13.8 0.6 1.2 8.9 0.0 3.5 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 KPI90281.1 - 0.063 12.8 0.6 0.38 10.3 0.0 2.6 3 0 0 3 3 3 0 CLASP N terminal Pkinase PF00069.25 KPI90282.1 - 5.4e-46 157.1 0.4 3.7e-26 92.1 0.1 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90282.1 - 5.5e-26 91.4 0.0 4.3e-21 75.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KPI90282.1 - 0.0003 20.2 0.1 0.013 14.9 0.1 2.2 2 0 0 2 2 2 1 Kinase-like FliT PF05400.13 KPI90282.1 - 0.92 10.4 4.8 0.56 11.0 0.4 2.4 2 0 0 2 2 2 0 Flagellar protein FliT AAA_lid_7 PF17867.1 KPI90285.1 - 0.041 14.1 0.6 0.24 11.6 0.2 2.5 2 0 0 2 2 2 0 Midasin AAA lid domain Pex14_N PF04695.13 KPI90286.1 - 2.6 8.7 6.5 5.4 7.7 0.0 2.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Helicase_C PF00271.31 KPI90287.1 - 3.4e-08 33.8 0.0 1e-07 32.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI90287.1 - 2.4e-05 24.2 0.0 7.8e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase TFIIA PF03153.13 KPI90287.1 - 1.1 9.1 23.7 2.9 7.8 23.7 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ceramidase PF05875.12 KPI90288.1 - 0.084 12.3 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Ceramidase JMY PF15871.5 KPI90289.1 - 0.017 14.4 11.6 0.2 10.9 0.9 2.8 2 1 1 3 3 3 0 Junction-mediating and -regulatory protein NODP PF07684.12 KPI90289.1 - 0.25 11.5 1.2 0.78 9.9 0.5 2.2 2 0 0 2 2 2 0 NOTCH protein DUF883 PF05957.13 KPI90289.1 - 0.57 10.8 6.0 2.3 8.9 2.0 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Peptidase_M41 PF01434.18 KPI90291.1 - 1.2e-44 152.5 0.0 3.4e-44 151.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 KPI90291.1 - 5.3e-34 117.5 0.0 1.4e-33 116.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KPI90291.1 - 2.2e-10 40.1 0.0 7.2e-10 38.5 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KPI90291.1 - 0.0014 18.9 0.4 0.62 10.3 0.1 2.9 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 KPI90291.1 - 0.0017 18.5 0.0 0.0065 16.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KPI90291.1 - 0.0019 18.2 0.6 0.052 13.5 0.6 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KPI90291.1 - 0.0061 17.1 0.1 0.034 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Podoplanin PF05808.11 KPI90291.1 - 0.011 15.8 0.6 6.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Podoplanin AAA_16 PF13191.6 KPI90291.1 - 0.016 15.6 1.4 0.042 14.2 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain RuvB_N PF05496.12 KPI90291.1 - 0.037 13.8 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PAD_porph PF04371.15 KPI90291.1 - 0.041 13.2 0.3 0.081 12.2 0.3 1.4 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase IstB_IS21 PF01695.17 KPI90291.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KPI90291.1 - 0.096 12.1 0.3 0.27 10.6 0.3 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KPI90291.1 - 0.16 12.1 0.6 0.32 11.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 KPI90291.1 - 0.4 10.9 0.0 0.4 10.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF2052 PF09747.9 KPI90291.1 - 1 9.5 13.3 0.09 12.9 3.2 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) C2 PF00168.30 KPI90293.1 - 5.3e-23 81.3 0.0 8e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain DOCK-C2 PF14429.6 KPI90293.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 C2 domain in Dock180 and Zizimin proteins FtsJ PF01728.19 KPI90296.1 - 1.4e-43 149.0 0.0 2.1e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Toxin_21 PF08091.11 KPI90296.1 - 0.0084 16.0 3.8 0.016 15.1 3.8 1.4 1 0 0 1 1 1 1 Spider insecticidal peptide Mrx7 PF10906.8 KPI90296.1 - 1.6 9.1 3.5 2.2 8.6 0.4 2.4 2 0 0 2 2 2 0 MIOREX complex component 7 Ribosomal_L7Ae PF01248.26 KPI90300.1 - 4.1e-06 26.4 0.1 9.4e-06 25.3 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Caprin-1_dimer PF18293.1 KPI90300.1 - 0.0085 16.6 0.4 0.019 15.4 0.4 1.6 1 0 0 1 1 1 1 Caprin-1 dimerization domain FA_hydroxylase PF04116.13 KPI90302.1 - 7.3e-16 58.7 14.2 7.3e-16 58.7 14.2 2.0 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Aa_trans PF01490.18 KPI90303.1 - 4e-47 160.8 32.8 5.1e-47 160.5 32.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KPI90304.1 - 3.2e-49 167.7 39.3 4.1e-49 167.4 39.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI90304.1 - 2.9e-06 26.6 20.3 2.9e-06 26.6 20.3 2.8 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family Alpha_E3_glycop PF01563.16 KPI90304.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Alphavirus E3 glycoprotein Aa_trans PF01490.18 KPI90305.1 - 3.9e-45 154.3 42.0 4.8e-45 154.0 42.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI90305.1 - 0.00056 19.0 33.0 0.00069 18.8 32.5 1.4 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family CHD5 PF04420.14 KPI90305.1 - 0.14 12.0 0.6 1.5 8.6 0.1 2.5 2 0 0 2 2 2 0 CHD5-like protein Aa_trans PF01490.18 KPI90307.1 - 1.2e-49 169.2 33.9 1.4e-49 168.9 33.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI90307.1 - 6.3e-11 41.9 11.3 6.3e-11 41.9 11.3 1.9 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family GHMP_kinases_C PF08544.13 KPI90308.1 - 1.8e-15 57.1 0.5 3.5e-15 56.1 0.5 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KPI90308.1 - 1.2e-12 47.8 1.2 2.8e-12 46.7 1.2 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain YcaO PF02624.16 KPI90308.1 - 0.16 11.3 0.0 0.26 10.5 0.0 1.4 1 1 0 1 1 1 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding ATG16 PF08614.11 KPI90309.1 - 0.023 14.9 62.2 0.035 14.3 0.2 5.9 4 1 2 6 6 6 0 Autophagy protein 16 (ATG16) Takusan PF04822.13 KPI90309.1 - 0.38 10.7 9.0 6 6.8 0.0 4.4 4 1 0 4 4 4 0 Takusan OmpH PF03938.14 KPI90309.1 - 0.39 11.0 49.1 0.4 11.0 4.3 4.8 4 1 1 5 5 5 0 Outer membrane protein (OmpH-like) ABC_membrane_2 PF06472.15 KPI90310.1 - 2.2e-58 197.8 3.9 3.2e-58 197.2 3.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KPI90310.1 - 7.1e-16 59.0 0.0 1.3e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 KPI90310.1 - 0.022 15.3 0.0 0.035 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KPI90310.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KPI90310.1 - 0.033 14.6 0.0 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain SMC_N PF02463.19 KPI90310.1 - 0.054 12.9 0.0 0.37 10.2 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KPI90310.1 - 0.078 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 KPI90310.1 - 0.087 12.7 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain TRM13 PF05206.14 KPI90313.1 - 4.4e-39 134.6 0.0 1.1e-26 93.9 0.0 3.2 1 1 1 2 2 2 2 Methyltransferase TRM13 zf-U11-48K PF05253.12 KPI90313.1 - 7.6e-10 38.5 2.2 1.7e-09 37.4 2.2 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger zf-TRM13_CCCH PF11722.8 KPI90313.1 - 7.5e-08 32.0 9.5 7.5e-08 32.0 9.5 2.2 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein DnaJ PF00226.31 KPI90314.1 - 1.8e-22 79.2 0.5 3.4e-22 78.3 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 KPI90314.1 - 1.4e-05 24.6 0.3 2.5e-05 23.8 0.3 1.4 1 0 0 1 1 1 1 X-domain of DnaJ-containing cNMP_binding PF00027.29 KPI90316.1 - 4e-20 71.7 0.2 1.8e-05 24.7 0.0 4.9 5 1 0 5 5 5 3 Cyclic nucleotide-binding domain Sulfotransfer_4 PF17784.1 KPI90317.1 - 1.2e-40 139.7 0.0 4.1e-40 137.9 0.0 1.8 1 1 0 1 1 1 1 Sulfotransferase domain CSN8_PSD8_EIF3K PF10075.9 KPI90317.1 - 0.11 12.5 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family AAA_16 PF13191.6 KPI90318.1 - 0.0016 18.8 0.0 0.0023 18.4 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KPI90318.1 - 0.024 15.0 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KPI90318.1 - 0.16 12.0 0.0 0.28 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain Peptidase_C2 PF00648.21 KPI90319.1 - 1.8e-70 237.3 0.0 2.7e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI90319.1 - 3.1e-14 53.2 0.0 7.1e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.21 KPI90320.1 - 9.4e-55 185.7 0.0 1.4e-54 185.2 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI90320.1 - 1.8e-21 76.4 0.0 4.6e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.21 KPI90321.1 - 1.8e-33 115.9 0.0 2.8e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI90321.1 - 3.8e-20 72.2 0.0 7.1e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.21 KPI90322.1 - 5.7e-15 55.1 0.0 1.1e-14 54.1 0.0 1.5 1 1 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI90322.1 - 7.4e-14 52.0 0.0 1.8e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.21 KPI90323.1 - 3.9e-27 95.1 0.0 7.3e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI90323.1 - 6.5e-13 49.0 0.1 1.9e-12 47.5 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Peptidase_C2 PF00648.21 KPI90324.1 - 4.1e-45 154.1 0.0 5.4e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DUF1935 PF09149.10 KPI90324.1 - 5.3e-25 87.8 0.0 9.5e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1935) Calpain_III PF01067.22 KPI90324.1 - 0.083 13.2 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Calpain large subunit, domain III DUF2972 PF11186.8 KPI90324.1 - 0.25 11.3 0.0 0.43 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) Peptidase_C47 PF05543.13 KPI90326.1 - 0.17 11.5 0.1 0.34 10.5 0.1 1.4 1 0 0 1 1 1 0 Staphopain peptidase C47 Capsid_VP7 PF17071.5 KPI90326.1 - 1.1 8.5 6.4 0.82 8.9 0.5 2.3 2 0 0 2 2 2 0 Outer capsid protein VP7 Codanin-1_C PF15296.6 KPI90326.1 - 2.2 8.4 5.4 1.1 9.3 0.0 2.9 3 0 0 3 3 3 0 Codanin-1 C-terminus CRAL_TRIO PF00650.20 KPI90327.1 - 3.3e-14 52.9 0.0 6.6e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain Aa_trans PF01490.18 KPI90328.1 - 9e-52 176.1 34.8 1.1e-51 175.9 34.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 KPI90328.1 - 2e-06 26.9 23.0 2e-06 26.9 23.0 2.0 2 0 0 2 2 2 1 Amino acid permease Trp_Tyr_perm PF03222.13 KPI90328.1 - 0.00015 20.9 17.2 0.00015 20.9 17.2 2.3 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 KPI90329.1 - 1.1e-59 202.2 34.1 1.3e-59 202.0 34.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 KPI90329.1 - 3.5e-08 32.7 17.9 3.5e-08 32.7 17.9 2.1 2 0 0 2 2 2 1 Amino acid permease Aa_trans PF01490.18 KPI90330.1 - 8.3e-17 61.0 9.2 9.9e-17 60.7 9.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI90330.1 - 1.3e-06 27.8 7.6 1.5e-06 27.5 7.6 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 KPI90331.1 - 3.2e-17 62.4 14.8 3.6e-17 62.2 14.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KPI90332.1 - 7.1e-44 150.1 37.2 8.7e-44 149.9 37.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KPI90332.1 - 5.2e-11 42.2 22.0 5.2e-11 42.2 22.0 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.6 KPI90332.1 - 6.7e-07 28.5 25.7 6.7e-07 28.5 25.7 2.1 1 1 1 2 2 2 1 Amino acid permease Goodbye PF17109.5 KPI90332.1 - 0.018 15.5 0.3 0.33 11.4 0.3 2.4 1 1 0 1 1 1 0 fungal STAND N-terminal Goodbye domain CRAL_TRIO PF00650.20 KPI90333.1 - 2.2e-12 47.0 0.0 4e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO PF00650.20 KPI90334.1 - 8.7e-17 61.3 0.1 1.4e-13 50.9 0.0 2.4 2 0 0 2 2 2 2 CRAL/TRIO domain Kinesin PF00225.23 KPI90335.1 - 6.1e-89 298.2 0.1 8.7e-89 297.7 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90335.1 - 1.3e-14 54.4 0.0 2.2e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding DUF3972 PF13118.6 KPI90335.1 - 0.031 14.7 0.1 0.071 13.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) TMF_DNA_bd PF12329.8 KPI90335.1 - 0.18 11.8 0.6 0.46 10.5 0.6 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding COPIIcoated_ERV PF07970.12 KPI90336.1 - 6.6e-18 65.4 0.0 9.2e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KPI90336.1 - 5e-09 36.4 0.0 9.7e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) 2OG-FeII_Oxy_3 PF13640.6 KPI90337.1 - 8.8e-15 55.4 0.0 1.6e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KPI90337.1 - 2.9e-10 40.7 0.0 4.9e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DnaJ PF00226.31 KPI90338.1 - 8.2e-06 25.9 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Suc_Fer-like PF06999.12 KPI90339.1 - 3e-27 95.8 0.0 3.9e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Ribosomal_S27e PF01667.17 KPI90339.1 - 0.066 12.9 1.4 0.14 11.9 1.4 1.5 1 0 0 1 1 1 0 Ribosomal protein S27 Zn_ribbon_SprT PF17283.2 KPI90339.1 - 0.19 11.6 3.5 0.49 10.3 3.5 1.7 1 0 0 1 1 1 0 SprT-like zinc ribbon domain Helicase_C PF00271.31 KPI90340.1 - 8.8e-10 38.9 0.0 2.2e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI90340.1 - 1.3e-05 25.1 0.0 3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase APG6_N PF17675.1 KPI90340.1 - 0.014 15.9 0.0 0.033 14.7 0.0 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Cupin_4 PF08007.12 KPI90341.1 - 1.4e-40 139.7 2.8 4.3e-40 138.1 2.8 1.8 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 KPI90341.1 - 8.1e-08 32.3 0.2 3.9e-07 30.0 0.1 2.1 2 1 0 2 2 2 1 Cupin-like domain Cupin_3 PF05899.12 KPI90341.1 - 0.0042 16.7 0.0 0.53 10.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 KPI90341.1 - 0.019 14.7 0.0 0.66 9.7 0.0 2.8 3 0 0 3 3 3 0 Cupin domain APOBEC_C PF05240.14 KPI90341.1 - 0.041 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 APOBEC-like C-terminal domain Fez1 PF06818.15 KPI90342.1 - 0.008 16.7 125.5 0.024 15.1 7.1 6.4 1 1 4 6 6 6 5 Fez1 Uteroglobin PF01099.17 KPI90342.1 - 1.9 8.9 4.9 27 5.2 0.5 3.6 2 0 0 2 2 2 0 Uteroglobin family DNA_pol_phi PF04931.13 KPI90343.1 - 0.024 12.8 16.8 0.03 12.4 16.8 1.4 1 0 0 1 1 1 0 DNA polymerase phi CSTF2_hinge PF14327.6 KPI90343.1 - 0.11 12.9 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 Nop14 PF04147.12 KPI90343.1 - 0.15 10.2 18.8 0.19 9.9 18.8 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 KPI90343.1 - 0.19 11.5 12.9 0.26 11.0 12.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 KPI90343.1 - 0.49 8.6 9.8 0.52 8.5 9.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 KPI90343.1 - 1.3 8.4 18.1 2.2 7.6 18.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop16 PF09420.10 KPI90343.1 - 1.5 8.8 5.9 2.2 8.3 5.9 1.2 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 SDA1 PF05285.12 KPI90343.1 - 2.8 7.3 27.5 4.2 6.7 27.5 1.2 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 KPI90343.1 - 6.1 5.5 5.3 6.2 5.5 5.3 1.1 1 0 0 1 1 1 0 Presenilin CLP1_P PF16575.5 KPI90344.1 - 7.2e-11 42.2 0.0 2.3e-10 40.6 0.0 1.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 KPI90344.1 - 1.3e-10 41.4 0.0 4e-10 39.8 0.0 1.8 2 0 0 2 2 2 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 KPI90344.1 - 5.4e-06 26.8 0.0 1.1e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 WD40 PF00400.32 KPI90346.1 - 2.3e-14 53.6 6.9 0.0042 17.9 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat NLE PF08154.12 KPI90346.1 - 1.6e-11 44.6 0.2 2.9e-11 43.7 0.2 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 KPI90346.1 - 8e-06 26.1 0.1 1 9.7 0.0 3.7 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 KPI90346.1 - 0.069 12.4 0.0 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Methyltr_RsmB-F PF01189.17 KPI90347.1 - 9e-69 231.1 0.0 2e-68 230.0 0.0 1.6 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 KPI90347.1 - 1.4e-07 31.9 0.0 5.9e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 KPI90347.1 - 0.00041 20.5 0.0 0.0011 19.1 0.0 1.6 1 1 1 2 2 2 1 FtsJ-like methyltransferase PCMT PF01135.19 KPI90347.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF2431 PF10354.9 KPI90347.1 - 0.096 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Kinesin_assoc PF16183.5 KPI90347.1 - 3.9 7.6 5.8 1.4 9.0 2.1 2.1 2 0 0 2 2 2 0 Kinesin-associated LRR_RI_capping PF18779.1 KPI90348.1 - 0.0085 15.7 0.7 0.02 14.5 0.2 1.8 2 0 0 2 2 2 1 Capping Ribonuclease inhibitor Leucine Rich Repeat Leu_zip PF15294.6 KPI90350.1 - 0.022 14.3 18.5 0.05 13.1 18.4 1.6 1 1 0 1 1 1 0 Leucine zipper DUF5319 PF17252.2 KPI90350.1 - 0.51 10.6 3.8 0.15 12.3 0.5 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5319) DUF3287 PF11690.8 KPI90350.1 - 0.51 10.1 7.8 0.2 11.4 2.1 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF3287) DUF724 PF05266.14 KPI90350.1 - 1.4 8.7 25.8 1.6 8.5 9.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Golgin_A5 PF09787.9 KPI90350.1 - 1.9 7.9 28.2 2.7 7.4 28.2 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Ax_dynein_light PF10211.9 KPI90350.1 - 2.3 8.1 22.6 0.051 13.5 11.4 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain TPR_MLP1_2 PF07926.12 KPI90350.1 - 2.5 8.2 32.7 0.43 10.6 21.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 KPI90350.1 - 3.4 6.9 28.1 2.8 7.2 7.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) GPHR_N PF12537.8 KPI90350.1 - 9 6.5 6.5 7.9 6.6 0.2 2.9 3 0 0 3 3 3 0 The Golgi pH Regulator (GPHR) Family N-terminal RNA_pol_Rpb2_6 PF00562.28 KPI90351.1 - 1.2e-120 403.2 0.0 1.5e-120 402.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KPI90351.1 - 5e-42 143.7 0.0 7.2e-42 143.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 KPI90351.1 - 4.9e-31 107.0 0.1 1.9e-30 105.1 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 KPI90351.1 - 5.5e-24 84.8 0.0 9e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 KPI90351.1 - 6.6e-23 80.8 1.7 1.4e-22 79.8 1.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KPI90351.1 - 2.6e-21 75.6 0.1 7.4e-21 74.1 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KPI90351.1 - 1.6e-09 38.2 0.9 4e-09 36.9 0.9 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 OrfB_Zn_ribbon PF07282.11 KPI90351.1 - 0.59 10.1 2.4 0.73 9.8 0.8 2.0 2 0 0 2 2 2 0 Putative transposase DNA-binding domain IncD PF17628.2 KPI90352.1 - 0.079 12.7 0.2 0.5 10.1 0.0 2.1 1 1 1 2 2 2 0 Inclusion membrane protein D UCH PF00443.29 KPI90353.1 - 5.5e-44 150.6 0.0 8.1e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI90353.1 - 1.1e-09 38.4 0.1 2.9e-08 33.7 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KPI90353.1 - 3.6e-09 36.3 0.0 8e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.6 KPI90353.1 - 0.0083 15.6 0.6 1.5 8.2 0.1 2.8 3 0 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Ubiquitin_2 PF14560.6 KPI90353.1 - 0.02 15.3 0.0 0.049 14.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain ZapB PF06005.12 KPI90354.1 - 0.023 15.1 0.3 0.023 15.1 0.3 9.0 2 1 4 6 6 6 0 Cell division protein ZapB Nup214_FG PF18617.1 KPI90354.1 - 0.078 13.5 1.4 0.15 12.6 1.4 1.4 1 0 0 1 1 1 0 Nucleoporin Nup214 phenylalanine-glycine (FG) domain Tht1 PF04163.12 KPI90354.1 - 1.6 7.4 7.5 2.7 6.7 7.5 1.2 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein VCBS PF13517.6 KPI90356.1 - 2.8e-15 56.6 14.8 0.0006 20.4 5.5 6.7 7 1 0 7 7 7 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KPI90356.1 - 9.7e-06 25.6 22.1 0.087 13.0 1.6 6.0 5 0 0 5 5 5 4 FG-GAP repeat PQQ_2 PF13360.6 KPI90356.1 - 0.0004 20.0 0.5 0.0087 15.7 0.1 2.5 2 1 1 3 3 3 2 PQQ-like domain DUF1533 PF07550.11 KPI90356.1 - 0.072 13.0 0.0 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) BBS2_C PF14782.6 KPI90356.1 - 0.19 10.5 0.1 15 4.2 0.0 2.9 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, C-terminal PQQ_3 PF13570.6 KPI90356.1 - 1.8 9.1 18.1 87 3.8 0.1 6.6 7 0 0 7 7 7 0 PQQ-like domain Peptidase_M22 PF00814.25 KPI90358.1 - 3.8e-87 292.4 0.0 4.9e-87 292.1 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 KPI90358.1 - 0.012 15.3 0.0 4.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus Mto2_bdg PF12808.7 KPI90358.1 - 0.12 12.7 0.5 0.2 12.0 0.5 1.3 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region zf-CCCH PF00642.24 KPI90360.1 - 9.8e-08 31.7 13.7 1.9e-06 27.7 5.9 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KPI90360.1 - 4e-07 29.7 12.7 3.4e-05 23.5 6.1 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KPI90360.1 - 3.2e-05 23.8 17.3 0.00016 21.6 8.6 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 KPI90360.1 - 0.11 13.2 7.4 0.14 12.9 5.9 2.0 1 1 0 1 1 1 0 Torus domain zf-CCCH_2 PF14608.6 KPI90360.1 - 4.6 7.9 10.6 34 5.1 0.2 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger ResIII PF04851.15 KPI90361.1 - 1.1e-16 61.3 0.0 2.7e-16 60.0 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI90361.1 - 4.5e-10 39.9 0.0 1.5e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI90361.1 - 6.3e-08 32.6 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase T5orf172 PF10544.9 KPI90361.1 - 4.9e-07 30.2 0.0 1.2e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 T5orf172 domain Jas PF16135.5 KPI90361.1 - 0.11 12.6 0.2 0.36 11.0 0.2 1.8 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling Pro_isomerase PF00160.21 KPI90363.1 - 2.3e-45 154.7 0.0 3e-45 154.3 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RINGv PF12906.7 KPI90364.1 - 1e-10 41.5 6.6 2.7e-10 40.2 6.6 1.8 1 0 0 1 1 1 1 RING-variant domain DUF1736 PF08409.11 KPI90364.1 - 0.16 12.0 2.4 0.18 11.8 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1736) MIP PF00230.20 KPI90365.1 - 9.7e-51 172.7 5.6 1.2e-50 172.4 5.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein ETF_alpha PF00766.19 KPI90365.1 - 0.2 11.7 0.8 0.61 10.2 0.8 1.8 1 1 0 1 1 1 0 Electron transfer flavoprotein FAD-binding domain Ferrochelatase PF00762.19 KPI90366.1 - 2.6e-12 46.5 0.2 2.6e-12 46.5 0.2 1.0 1 0 0 1 1 1 1 Ferrochelatase Lysis_col PF02402.16 KPI90367.1 - 0.038 13.7 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 Lysis protein LacI PF00356.21 KPI90368.1 - 1.3 8.9 4.8 0.96 9.3 2.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family PH PF00169.29 KPI90369.1 - 5.1e-10 39.8 1.3 0.0003 21.2 0.3 2.5 2 0 0 2 2 2 2 PH domain Kelch_3 PF13415.6 KPI90369.1 - 0.00021 21.5 2.8 0.07 13.5 0.0 5.0 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KPI90369.1 - 0.0018 17.8 1.9 0.42 10.2 0.7 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 KPI90369.1 - 0.014 15.4 2.8 11 6.2 0.0 4.4 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_5 PF13854.6 KPI90369.1 - 0.016 15.2 0.8 12 6.0 0.0 4.0 4 0 0 4 4 4 0 Kelch motif PH_8 PF15409.6 KPI90369.1 - 1.1 9.5 2.5 1.6 9.1 0.4 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain DUF1796 PF08795.10 KPI90370.1 - 0.024 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Sde2_N_Ubi PF13019.6 KPI90370.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain DUF1796 PF08795.10 KPI90371.1 - 1.8e-38 132.1 0.1 1.7e-37 129.0 0.1 1.9 1 1 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) Pkinase PF00069.25 KPI90372.1 - 1.2e-32 113.3 0.0 1.1e-10 41.3 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90372.1 - 1.2e-15 57.5 0.1 1.9e-05 24.1 0.2 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase PseudoU_synth_1 PF01416.20 KPI90373.1 - 5.1e-27 94.5 0.0 4.2e-26 91.5 0.0 2.3 2 0 0 2 2 2 1 tRNA pseudouridine synthase Adaptin_N PF01602.20 KPI90374.1 - 2.4e-57 194.7 0.0 1.7e-55 188.6 0.1 2.1 2 0 0 2 2 2 2 Adaptin N terminal region AP4E_app_platf PF14807.6 KPI90374.1 - 2.8e-14 53.3 0.1 6e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.7 KPI90374.1 - 2e-06 27.9 0.0 0.0018 18.3 0.0 2.5 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KPI90374.1 - 2.6e-06 27.7 7.8 0.075 13.4 0.1 5.2 5 1 1 6 6 6 3 HEAT repeats Cnd3 PF12719.7 KPI90374.1 - 0.0036 16.5 0.2 0.0073 15.5 0.2 1.4 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 KPI90374.1 - 0.02 15.4 0.1 0.02 15.4 0.1 5.8 7 0 0 7 7 7 0 HEAT-like repeat HEAT PF02985.22 KPI90374.1 - 0.027 14.7 7.6 7.9 7.0 0.2 5.6 6 0 0 6 6 6 0 HEAT repeat CLASP_N PF12348.8 KPI90374.1 - 0.052 13.1 0.2 0.3 10.6 0.0 2.2 2 0 0 2 2 2 0 CLASP N terminal Flavoprotein PF02441.19 KPI90375.1 - 1.9e-44 151.2 0.6 2e-41 141.4 0.5 2.2 1 1 1 2 2 2 2 Flavoprotein Rad17 PF03215.15 KPI90376.1 - 0.00047 20.1 0.0 0.00079 19.4 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 KPI90376.1 - 0.16 12.3 0.0 0.16 12.3 0.0 2.6 3 0 0 3 3 3 0 AAA C-terminal domain PseudoU_synth_2 PF00849.22 KPI90377.1 - 3.8e-35 121.4 0.1 4.5e-34 117.8 0.1 2.2 1 1 0 1 1 1 1 RNA pseudouridylate synthase Gasdermin PF04598.12 KPI90377.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Gasdermin pore forming domain S1-P1_nuclease PF02265.16 KPI90378.1 - 2.3e-60 204.5 0.0 3e-60 204.2 0.0 1.1 1 0 0 1 1 1 1 S1/P1 Nuclease Neuregulin PF02158.15 KPI90378.1 - 0.029 13.7 0.0 0.043 13.2 0.0 1.1 1 0 0 1 1 1 0 Neuregulin intracellular region Kinesin PF00225.23 KPI90379.1 - 6e-85 285.1 0.1 6e-85 285.1 0.1 2.0 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90379.1 - 3.4e-19 69.2 0.0 7.9e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Nop14 PF04147.12 KPI90379.1 - 0.00062 18.1 18.9 0.00062 18.1 18.9 2.1 2 0 0 2 2 2 1 Nop14-like family SR-25 PF10500.9 KPI90379.1 - 0.32 10.6 37.7 0.02 14.5 25.6 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PLAC8 PF04749.17 KPI90381.1 - 5.8e-10 40.1 23.7 8.6e-10 39.5 23.7 1.3 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KPI90382.1 - 3.1e-13 50.6 26.1 4.3e-13 50.1 26.1 1.2 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KPI90383.1 - 9.2e-14 52.2 28.8 1.2e-13 51.9 28.8 1.2 1 0 0 1 1 1 1 PLAC8 family WD40 PF00400.32 KPI90384.1 - 5.8e-15 55.4 9.7 0.0044 17.8 0.3 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90384.1 - 0.001 19.3 0.0 0.32 11.3 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KPI90384.1 - 0.0042 17.5 2.5 11 6.6 0.1 5.2 5 0 0 5 5 5 1 PQQ-like domain PLAC8 PF04749.17 KPI90385.1 - 2e-16 60.8 13.0 2.8e-16 60.3 13.0 1.2 1 0 0 1 1 1 1 PLAC8 family PSP1 PF04468.12 KPI90388.1 - 2.3e-11 43.8 0.3 3.7e-11 43.1 0.3 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region RIO1 PF01163.22 KPI90389.1 - 4.1e-46 156.9 0.0 9.4e-46 155.8 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 KPI90389.1 - 1.1e-32 112.1 0.2 2.4e-31 107.8 0.3 2.4 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 KPI90389.1 - 5.7e-10 39.5 0.1 7.7e-06 26.0 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KPI90389.1 - 0.0045 16.4 0.0 0.0045 16.4 0.0 3.0 4 1 0 4 4 4 1 Lipopolysaccharide kinase (Kdo/WaaP) family RabGAP-TBC PF00566.18 KPI90390.1 - 3.5e-37 128.2 0.3 1.3e-36 126.3 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain MASE1 PF05231.14 KPI90390.1 - 0.03 13.5 0.2 0.051 12.7 0.2 1.2 1 0 0 1 1 1 0 MASE1 ABC_tran PF00005.27 KPI90392.1 - 1.9e-33 115.9 0.4 5.7e-17 62.5 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KPI90392.1 - 1.6e-14 54.5 5.0 1.6e-05 24.8 0.1 4.1 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KPI90392.1 - 1.7e-10 41.6 0.7 2.9e-05 24.5 0.2 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 KPI90392.1 - 8.4e-10 38.2 0.3 0.00097 18.8 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 KPI90392.1 - 1.3e-09 37.8 3.6 0.045 13.2 0.1 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KPI90392.1 - 7.2e-08 32.5 0.1 0.017 15.0 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_23 PF13476.6 KPI90392.1 - 9.3e-07 29.5 0.2 0.03 14.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 KPI90392.1 - 2.8e-06 27.5 2.1 0.05 13.7 0.2 2.4 2 0 0 2 2 2 2 Dynamin family AAA_15 PF13175.6 KPI90392.1 - 1.1e-05 25.4 1.3 0.11 12.1 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 KPI90392.1 - 5.4e-05 23.3 0.5 0.18 11.9 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_24 PF13479.6 KPI90392.1 - 6.6e-05 22.7 0.0 0.17 11.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 KPI90392.1 - 7.5e-05 22.4 0.8 0.14 11.7 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_28 PF13521.6 KPI90392.1 - 0.00013 22.3 2.1 0.56 10.4 0.1 3.0 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 KPI90392.1 - 0.00013 21.3 0.1 0.23 10.7 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.17 KPI90392.1 - 0.00014 21.7 0.8 6.6 6.4 0.0 4.1 4 0 0 4 4 4 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 KPI90392.1 - 0.00021 20.7 0.2 0.53 9.6 0.0 2.7 3 0 0 3 3 2 2 FtsK/SpoIIIE family AAA_33 PF13671.6 KPI90392.1 - 0.00023 21.3 2.4 0.13 12.4 0.1 2.5 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 KPI90392.1 - 0.00038 19.6 0.0 0.46 9.5 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein G-alpha PF00503.20 KPI90392.1 - 0.0004 19.7 0.0 0.31 10.1 0.0 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 KPI90392.1 - 0.00078 18.9 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_18 PF13238.6 KPI90392.1 - 0.00081 19.9 0.1 1.1 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KPI90392.1 - 0.0012 18.3 0.1 1.8 8.0 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region SRP54 PF00448.22 KPI90392.1 - 0.0018 17.9 0.1 0.17 11.5 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain MeaB PF03308.16 KPI90392.1 - 0.0026 16.8 0.0 0.96 8.4 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_ab PF00006.25 KPI90392.1 - 0.0027 17.4 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.12 KPI90392.1 - 0.0028 17.6 3.2 0.67 9.9 0.0 2.9 3 0 0 3 3 2 1 NACHT domain AAA_22 PF13401.6 KPI90392.1 - 0.0028 17.9 5.2 0.82 9.9 0.1 3.5 3 1 0 3 3 3 1 AAA domain Roc PF08477.13 KPI90392.1 - 0.0032 17.7 0.1 2.5 8.3 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 KPI90392.1 - 0.004 16.9 0.2 2.1 8.1 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 KPI90392.1 - 0.0073 15.9 0.4 2.9 7.5 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DLIC PF05783.11 KPI90392.1 - 0.012 14.5 0.1 0.82 8.4 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) RNA_helicase PF00910.22 KPI90392.1 - 0.015 15.6 0.1 9 6.7 0.1 2.4 2 0 0 2 2 2 0 RNA helicase Septin PF00735.18 KPI90392.1 - 0.018 14.3 0.3 2.9 7.1 0.1 2.3 2 0 0 2 2 2 0 Septin AAA_30 PF13604.6 KPI90392.1 - 0.025 14.3 0.8 4.8 6.8 0.0 2.9 3 1 0 3 3 2 0 AAA domain VirE PF05272.11 KPI90392.1 - 0.029 14.1 0.0 0.54 10.0 0.0 2.1 2 0 0 2 2 2 0 Virulence-associated protein E AIG1 PF04548.16 KPI90392.1 - 0.031 13.6 0.7 1 8.7 0.1 2.4 2 0 0 2 2 2 0 AIG1 family Ploopntkinase1 PF18748.1 KPI90392.1 - 0.067 12.7 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 ATP_bind_1 PF03029.17 KPI90392.1 - 0.068 12.9 0.4 3.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DAP3 PF10236.9 KPI90392.1 - 0.069 12.3 1.6 5.6 6.0 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 KPI90392.1 - 0.083 12.9 0.2 22 5.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain Ploopntkinase3 PF18751.1 KPI90392.1 - 0.093 12.6 0.3 8.7 6.2 0.1 2.6 2 1 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA PF00004.29 KPI90392.1 - 0.099 13.1 0.1 28 5.2 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 KPI90392.1 - 0.1 12.5 0.1 11 5.8 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_13 PF13166.6 KPI90392.1 - 0.13 10.8 0.1 4.7 5.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 KPI90392.1 - 0.14 11.6 0.2 13 5.3 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B Rad17 PF03215.15 KPI90392.1 - 0.15 12.0 0.0 7.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain SRPRB PF09439.10 KPI90392.1 - 0.15 11.5 0.0 12 5.3 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF815 PF05673.13 KPI90392.1 - 0.17 11.0 1.0 11 5.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 KPI90392.1 - 0.2 11.3 0.1 28 4.4 0.0 2.7 3 0 0 3 3 2 0 Sigma-54 interaction domain CLP1_P PF16575.5 KPI90392.1 - 0.24 11.2 0.6 6.4 6.5 0.0 2.3 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SbcCD_C PF13558.6 KPI90392.1 - 0.28 11.5 0.8 7.2 6.9 0.1 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF3584 PF12128.8 KPI90392.1 - 0.33 8.4 3.2 4.1 4.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_5 PF07728.14 KPI90392.1 - 0.39 10.7 2.1 10 6.1 0.1 2.7 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 KPI90392.1 - 0.41 11.0 2.7 16 5.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain SNF2_N PF00176.23 KPI90394.1 - 7.6e-45 153.1 0.0 1.4e-44 152.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KPI90394.1 - 1.9e-09 37.8 0.0 4.2e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI90394.1 - 1.4e-05 25.1 0.0 3.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KPI90394.1 - 0.02 14.1 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Brix PF04427.18 KPI90395.1 - 1.8e-29 103.3 0.4 2.4e-29 102.8 0.4 1.2 1 0 0 1 1 1 1 Brix domain Sarcoglycan_2 PF05510.13 KPI90395.1 - 0.12 11.1 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Clathrin PF00637.20 KPI90396.1 - 4.8e-06 26.5 0.0 1.9e-05 24.5 0.2 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS LysM PF01476.20 KPI90396.1 - 0.00041 20.4 0.0 0.00096 19.2 0.0 1.6 1 0 0 1 1 1 1 LysM domain ANAPC4_WD40 PF12894.7 KPI90396.1 - 0.16 12.3 0.0 1.4 9.3 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_19 PF14559.6 KPI90396.1 - 0.16 12.5 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_5 PF14634.6 KPI90396.1 - 2.9 7.9 8.3 15 5.6 8.3 2.2 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 KPI90396.1 - 4.7 7.2 7.0 0.68 9.9 2.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Takusan PF04822.13 KPI90397.1 - 0.039 13.8 0.5 0.039 13.8 0.5 2.7 2 0 0 2 2 2 0 Takusan UPF0242 PF06785.11 KPI90397.1 - 0.045 13.8 0.5 0.045 13.8 0.5 3.8 2 1 1 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus Filament PF00038.21 KPI90397.1 - 1.1 8.8 34.2 0.75 9.3 11.1 4.1 4 0 0 4 4 4 0 Intermediate filament protein DUF4140 PF13600.6 KPI90397.1 - 1.1 9.7 24.3 9.3 6.8 0.1 4.8 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) LPP PF04728.13 KPI90397.1 - 2.7 8.4 12.1 35 4.9 0.1 4.7 4 0 0 4 4 4 0 Lipoprotein leucine-zipper DUF16 PF01519.16 KPI90397.1 - 3 8.4 10.6 2.2 8.8 0.4 3.6 1 1 2 3 3 3 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 KPI90397.1 - 3.5 8.2 9.5 21 5.7 0.6 4.2 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Phage_GP20 PF06810.11 KPI90397.1 - 3.9 7.3 16.1 0.75 9.6 0.4 3.8 3 2 1 4 4 4 0 Phage minor structural protein GP20 BRE1 PF08647.11 KPI90397.1 - 5.8 7.1 25.2 0.59 10.3 1.0 4.4 3 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase TMF_DNA_bd PF12329.8 KPI90397.1 - 9.8 6.3 19.4 0.13 12.3 1.0 4.5 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Acetyltransf_7 PF13508.7 KPI90399.1 - 7.1e-05 23.2 0.0 0.00096 19.5 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KPI90399.1 - 0.00086 19.2 0.1 0.062 13.3 0.0 2.4 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_1 PF00583.25 KPI90399.1 - 0.0014 18.9 0.0 0.004 17.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 KPI90399.1 - 0.0036 17.4 0.0 0.021 14.9 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 KPI90399.1 - 0.053 13.5 0.1 0.17 11.9 0.1 1.9 1 1 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_10 PF13673.7 KPI90399.1 - 0.13 12.2 0.0 0.56 10.2 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Phos_pyr_kin PF08543.12 KPI90400.1 - 2.6e-16 59.7 0.0 3.4e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 KPI90400.1 - 1.9e-10 40.6 0.5 2.9e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 pfkB family carbohydrate kinase EF-hand_7 PF13499.6 KPI90401.1 - 1.6e-06 28.5 0.6 0.0014 19.1 0.1 2.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI90401.1 - 0.0069 16.2 0.0 0.035 14.0 0.0 2.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 KPI90401.1 - 0.019 14.5 0.1 0.043 13.3 0.1 1.6 1 0 0 1 1 1 0 EF hand zf-C3HC4_3 PF13920.6 KPI90402.1 - 3.7e-06 26.7 16.5 3.7e-06 26.7 16.5 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KPI90402.1 - 0.0034 17.2 16.7 0.0034 17.2 16.7 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 KPI90402.1 - 3.3 7.0 16.2 1.7 7.9 4.4 2.6 2 1 0 2 2 2 0 Rtf2 RING-finger AAA_28 PF13521.6 KPI90403.1 - 2.2e-19 70.3 0.0 4.2e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 KPI90403.1 - 0.0066 15.5 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB LSM PF01423.22 KPI90404.1 - 7.6e-16 57.6 0.2 8.5e-16 57.4 0.2 1.0 1 0 0 1 1 1 1 LSM domain UCH PF00443.29 KPI90405.1 - 2.5e-35 122.2 0.0 4e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI90405.1 - 1.3e-07 31.5 5.2 2.9e-06 27.1 5.2 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf_UBZ PF18439.1 KPI90405.1 - 0.041 13.5 4.4 3.8 7.2 0.2 3.0 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TMEM107 PF14995.6 KPI90406.1 - 3e-22 79.3 4.8 3.3e-22 79.2 4.8 1.0 1 0 0 1 1 1 1 Transmembrane protein Papilloma_E5 PF03025.14 KPI90406.1 - 2.1 8.6 7.0 7.6 6.8 2.2 2.1 1 1 1 2 2 2 0 Papillomavirus E5 DHHC PF01529.20 KPI90407.1 - 2.2e-29 102.2 14.5 4.5e-29 101.3 14.5 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase DDE_Tnp_1 PF01609.21 KPI90407.1 - 0.066 12.9 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Transposase DDE domain TFIIF_alpha PF05793.12 KPI90408.1 - 0.0061 15.2 8.5 0.012 14.3 8.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MA3 PF02847.17 KPI90409.1 - 2.8e-09 37.0 0.1 1.3e-08 34.8 0.1 2.1 2 0 0 2 2 2 1 MA3 domain eIF-3_zeta PF05091.12 KPI90409.1 - 0.37 9.7 7.6 0.58 9.1 7.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4778 PF16008.5 KPI90409.1 - 2.9 7.9 10.6 7.5 6.5 10.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Oxidored_q2 PF00420.24 KPI90410.1 - 0.17 11.5 4.7 0.16 11.6 1.1 2.1 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Spo7 PF03907.13 KPI90410.1 - 2.7 7.4 5.1 0.89 9.0 2.0 1.6 2 0 0 2 2 2 0 Spo7-like protein Arm PF00514.23 KPI90412.1 - 4.9e-67 220.1 18.9 6.6e-11 41.9 0.1 8.8 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KPI90412.1 - 2e-15 56.1 0.1 4.3e-15 55.0 0.1 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 KPI90412.1 - 2e-13 50.5 1.2 0.009 16.4 0.0 5.4 3 1 3 6 6 6 4 HEAT repeats HEAT_EZ PF13513.6 KPI90412.1 - 2.9e-12 46.8 9.6 0.0023 18.4 0.3 6.8 4 3 4 8 8 8 3 HEAT-like repeat HEAT PF02985.22 KPI90412.1 - 3.6e-08 33.0 12.7 0.13 12.6 0.1 7.9 9 0 0 9 9 9 2 HEAT repeat Arm_2 PF04826.13 KPI90412.1 - 0.0092 15.5 0.0 5.3 6.4 0.0 3.4 3 1 0 3 3 3 1 Armadillo-like DCB PF16213.5 KPI90412.1 - 0.014 15.1 0.6 0.029 14.0 0.0 1.8 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Proteasom_PSMB PF10508.9 KPI90412.1 - 0.09 11.3 0.2 0.75 8.2 0.0 2.0 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit RRM_1 PF00076.22 KPI90413.1 - 1.3e-20 72.9 0.0 1.8e-08 34.1 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 KPI90413.1 - 0.0018 18.3 0.0 0.42 10.7 0.0 2.4 2 0 0 2 2 2 2 RNA binding domain Nup35_RRM_2 PF14605.6 KPI90413.1 - 0.028 14.4 0.0 3.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 KPI90413.1 - 0.15 11.9 0.0 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) DREV PF05219.12 KPI90414.1 - 2.2e-62 210.5 0.0 2.7e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_12 PF08242.12 KPI90414.1 - 4.8e-11 43.3 0.0 7.7e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI90414.1 - 8.2e-11 42.0 0.0 1.1e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI90414.1 - 8.7e-11 42.3 0.0 1.5e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KPI90414.1 - 1.7e-08 35.1 0.0 3e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KPI90414.1 - 0.00037 20.3 0.1 0.0016 18.3 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 KPI90414.1 - 0.0024 17.4 0.0 0.0037 16.8 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain WW PF00397.26 KPI90415.1 - 1.8e-10 40.7 3.9 3.3e-10 39.9 3.9 1.5 1 0 0 1 1 1 1 WW domain SelP_N PF04592.14 KPI90415.1 - 0.021 14.3 12.6 0.037 13.4 12.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region IQ PF00612.27 KPI90416.1 - 0.00018 21.0 25.0 0.31 10.9 0.6 5.5 6 0 0 6 6 6 4 IQ calmodulin-binding motif EIN3 PF04873.13 KPI90416.1 - 0.058 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Ethylene insensitive 3 Sdh5 PF03937.16 KPI90417.1 - 2e-20 72.5 0.7 3.9e-20 71.6 0.7 1.5 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase RF-1 PF00472.20 KPI90418.1 - 3.3e-15 56.0 0.0 5.1e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 KPI90418.1 - 0.0027 18.1 0.0 0.0036 17.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein TRF PF08558.10 KPI90418.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) Mito_carr PF00153.27 KPI90419.1 - 4.3e-47 158.0 4.6 3.9e-19 68.4 0.8 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KPI90419.1 - 0.00064 19.0 2.0 1.4 8.0 0.2 3.4 2 1 1 3 3 3 3 Gammaproteobacterial serine protease DUF4396 PF14342.6 KPI90419.1 - 0.052 13.9 4.2 0.11 12.8 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4396) zf-CCHC_2 PF13696.6 KPI90420.1 - 2 8.3 4.2 1.3 8.9 1.4 2.1 2 0 0 2 2 2 0 Zinc knuckle DnaJ PF00226.31 KPI90421.1 - 1.1e-20 73.5 0.2 2e-20 72.7 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain RseA_C PF03873.13 KPI90421.1 - 0.17 12.1 4.4 2.4 8.5 0.1 2.8 2 0 0 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain Ribosomal_60s PF00428.19 KPI90421.1 - 5.8 7.6 0.0 5.8 7.6 0.0 3.3 2 1 0 2 2 2 0 60s Acidic ribosomal protein Ufd2P_core PF10408.9 KPI90423.1 - 2.6e-91 307.2 0.0 3.1e-91 306.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core Thioredoxin PF00085.20 KPI90423.1 - 1.6e-23 82.6 0.0 3.4e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KPI90423.1 - 1.6e-07 31.0 0.0 3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KPI90423.1 - 1.8e-06 28.4 0.1 7.5e-06 26.4 0.1 2.1 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KPI90423.1 - 0.0003 21.0 0.0 0.043 14.1 0.0 2.8 1 1 1 2 2 2 2 Thioredoxin-like U-box PF04564.15 KPI90423.1 - 0.0022 18.2 0.2 0.014 15.5 0.2 2.5 1 1 0 1 1 1 1 U-box domain Thioredoxin_9 PF14595.6 KPI90423.1 - 0.004 16.9 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 KPI90423.1 - 0.0041 17.0 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KPI90423.1 - 0.036 13.8 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 Redoxin Pkinase PF00069.25 KPI90424.1 - 3.2e-34 118.5 0.0 1.4e-17 64.0 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90424.1 - 2.6e-23 82.6 0.1 1.4e-14 54.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KPI90424.1 - 5.7e-07 29.7 0.3 8.2e-05 22.6 0.3 2.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KPI90424.1 - 0.0003 20.2 0.0 0.019 14.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like UIM PF02809.20 KPI90425.1 - 0.91 9.6 4.1 2 8.5 4.1 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif APG5 PF04106.12 KPI90426.1 - 0.071 12.7 0.0 0.67 9.5 0.0 2.0 1 1 0 1 1 1 0 Autophagy protein Apg5 MAM33 PF02330.16 KPI90427.1 - 3.6e-29 102.2 0.3 2.8e-25 89.5 0.7 2.1 1 1 1 2 2 2 2 Mitochondrial glycoprotein WD40 PF00400.32 KPI90429.1 - 4e-17 62.3 13.7 1.5e-05 25.6 0.9 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 KPI90429.1 - 2.3e-07 31.0 0.0 6.2e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 KPI90429.1 - 1.5e-05 25.2 0.2 0.02 15.2 0.0 3.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain GCP_C_terminal PF04130.13 KPI90430.1 - 5.2e-22 78.7 0.0 1.2e-21 77.5 0.0 1.6 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KPI90430.1 - 4.3e-07 29.9 0.0 4.5e-06 26.5 0.0 2.2 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF4139 PF13598.6 KPI90431.1 - 1.1e-43 149.3 0.0 2.1e-43 148.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 KPI90431.1 - 0.00011 22.6 1.5 0.00024 21.5 0.7 2.0 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) CCB1 PF12046.8 KPI90431.1 - 0.034 13.5 0.2 0.075 12.4 0.2 1.5 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B APG6_N PF17675.1 KPI90431.1 - 0.41 11.2 4.4 5.6 7.5 0.6 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region NUDE_C PF04880.13 KPI90431.1 - 0.45 11.0 2.5 0.89 10.0 2.2 1.6 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region HECT PF00632.25 KPI90433.1 - 7.4e-74 249.0 0.0 1e-73 248.5 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PSK_trans_fac PF07704.11 KPI90433.1 - 0.22 12.3 4.6 0.8 10.5 4.6 1.9 1 0 0 1 1 1 0 Rv0623-like transcription factor PfkB PF00294.24 KPI90435.1 - 9e-32 110.6 0.2 1.3e-31 110.1 0.2 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase PfkB PF00294.24 KPI90436.1 - 9.1e-57 192.7 0.0 1.1e-56 192.4 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Amastin PF07344.11 KPI90437.1 - 4.7e-38 130.5 6.0 6.1e-38 130.1 6.0 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein DUF3808 PF10300.9 KPI90438.1 - 2e-40 139.0 3.7 3e-40 138.4 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) DUF4094 PF13334.6 KPI90439.1 - 0.018 15.4 1.2 0.048 14.1 1.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Sec5 PF15469.6 KPI90439.1 - 0.062 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec5 Fib_alpha PF08702.10 KPI90439.1 - 0.23 11.6 2.0 0.59 10.3 2.0 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family p25-alpha PF05517.12 KPI90440.1 - 3.6e-36 124.7 8.1 4e-36 124.5 8.1 1.0 1 0 0 1 1 1 1 p25-alpha EF-hand_7 PF13499.6 KPI90440.1 - 0.093 13.2 0.1 0.17 12.4 0.1 1.4 1 0 0 1 1 1 0 EF-hand domain pair IF2_N PF04760.15 KPI90440.1 - 0.16 11.8 1.3 0.19 11.6 0.2 1.7 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region p25-alpha PF05517.12 KPI90441.1 - 8.2e-36 123.5 5.4 9.1e-36 123.4 5.4 1.0 1 0 0 1 1 1 1 p25-alpha Kinesin PF00225.23 KPI90442.1 - 1.2e-87 293.9 0.0 1.7e-87 293.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90442.1 - 1.1e-21 77.4 0.0 4.3e-19 68.9 0.0 2.6 2 0 0 2 2 2 2 Microtubule binding DEAD PF00270.29 KPI90443.1 - 2.2e-07 30.8 0.0 4.3e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI90443.1 - 3.2e-05 24.2 0.0 0.00015 22.1 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_7 PF12775.7 KPI90443.1 - 0.0022 17.5 0.0 0.0046 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region UvrD-helicase PF00580.21 KPI90443.1 - 0.03 13.9 0.0 0.059 12.9 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 KPI90443.1 - 0.057 13.7 0.0 0.61 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 KPI90443.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UQ_con PF00179.26 KPI90444.1 - 3.9e-23 81.6 0.0 4.6e-23 81.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Zeta_toxin PF06414.12 KPI90445.1 - 8.2e-11 41.5 0.0 1.9e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 KPI90445.1 - 0.091 13.3 0.0 0.24 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Peptidase_C15 PF01470.17 KPI90446.1 - 1.2e-12 48.5 0.0 6e-05 23.3 0.0 2.6 2 1 0 2 2 2 2 Pyroglutamyl peptidase PTE PF02126.18 KPI90446.1 - 0.08 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotriesterase family RCC1 PF00415.18 KPI90448.1 - 1e-26 93.3 1.5 1.1e-08 35.5 0.2 4.9 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KPI90448.1 - 2.1e-15 56.1 15.4 7.4e-09 35.2 1.5 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat TPR_12 PF13424.6 KPI90449.1 - 5.9e-05 23.3 0.0 5.9e-05 23.3 0.0 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90449.1 - 0.006 16.6 0.1 12 6.3 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat IQ PF00612.27 KPI90449.1 - 0.0062 16.2 1.8 0.0062 16.2 1.8 6.4 6 0 0 6 6 6 4 IQ calmodulin-binding motif TPR_10 PF13374.6 KPI90449.1 - 0.0085 15.9 16.1 0.35 10.8 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat DEAD PF00270.29 KPI90451.1 - 3e-44 150.9 0.0 6.2e-44 149.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI90451.1 - 3.8e-23 82.0 0.0 1e-22 80.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 KPI90451.1 - 1.1e-10 41.6 4.6 3e-10 40.2 4.6 1.8 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 KPI90451.1 - 8.6e-06 25.8 0.0 2.7e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KPI90451.1 - 0.15 12.4 0.9 1.3 9.3 0.4 2.8 2 1 0 2 2 2 0 AAA domain DUF5089 PF17002.5 KPI90451.1 - 0.2 11.5 6.6 0.032 14.1 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) UvrD-helicase PF00580.21 KPI90451.1 - 0.8 9.2 9.2 2.3 7.6 0.0 2.7 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain FtsX PF02687.21 KPI90453.1 - 2.1e-13 50.6 22.8 4.8e-11 43.0 8.3 6.9 6 1 1 7 7 7 2 FtsX-like permease family DUF4191 PF13829.6 KPI90453.1 - 0.0074 15.6 1.2 0.0074 15.6 1.2 3.9 4 1 0 4 4 4 1 Domain of unknown function (DUF4191) Colicin_K PF17500.2 KPI90453.1 - 0.43 11.2 4.4 5.3 7.7 4.1 2.9 1 1 1 2 2 2 0 Colicin-K FtsX PF02687.21 KPI90454.1 - 2.5e-10 40.7 25.7 5.3e-09 36.4 7.4 6.3 6 1 0 6 6 6 2 FtsX-like permease family DUF724 PF05266.14 KPI90455.1 - 0.017 15.0 4.6 0.049 13.5 4.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Fez1 PF06818.15 KPI90455.1 - 0.14 12.6 18.9 0.19 12.1 15.0 2.6 1 1 1 2 2 2 0 Fez1 Exonuc_VII_L PF02601.15 KPI90455.1 - 0.92 9.0 8.9 13 5.2 10.1 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit Leu_zip PF15294.6 KPI90455.1 - 2.9 7.4 10.1 6.5 6.2 10.1 1.5 1 0 0 1 1 1 0 Leucine zipper Pkinase PF00069.25 KPI90456.1 - 4e-57 193.6 0.0 5.3e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90456.1 - 7e-31 107.5 0.0 9.4e-31 107.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KPI90456.1 - 0.00082 18.8 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KPI90456.1 - 0.13 11.0 0.0 0.24 10.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PLDc_2 PF13091.6 KPI90458.1 - 3.6e-30 104.6 0.0 2.9e-22 79.0 0.0 2.5 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KPI90458.1 - 3.1e-08 33.5 1.5 0.0059 16.7 0.0 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif Tim17 PF02466.19 KPI90459.1 - 0.19 12.1 7.3 0.17 12.3 5.3 1.9 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family ubiquitin PF00240.23 KPI90460.1 - 1.4e-16 60.0 0.0 1.6e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KPI90460.1 - 5.5e-07 29.3 0.0 5.9e-07 29.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 KPI90460.1 - 0.0008 19.5 0.1 0.0016 18.5 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 KPI90460.1 - 0.0028 18.0 0.0 0.0031 17.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_2 PF14560.6 KPI90460.1 - 0.018 15.5 0.0 0.037 14.5 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain DoxX PF07681.12 KPI90461.1 - 0.00047 20.7 8.3 0.00047 20.7 8.3 1.5 2 0 0 2 2 2 1 DoxX TMEM101 PF15111.6 KPI90461.1 - 0.012 15.1 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 TMEM101 protein family HR_lesion PF05514.11 KPI90461.1 - 0.017 15.3 4.2 0.032 14.4 4.2 1.6 1 1 0 1 1 1 0 HR-like lesion-inducing DUF4239 PF14023.6 KPI90461.1 - 0.033 13.9 1.2 0.043 13.5 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) SIR2 PF02146.17 KPI90462.1 - 3.6e-48 163.8 0.0 4.7e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TraU PF06834.11 KPI90462.1 - 0.032 13.5 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 TraU protein DUF35_N PF12172.8 KPI90462.1 - 0.059 13.3 0.1 3.1 7.8 0.0 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) POR_N PF01855.19 KPI90462.1 - 0.21 11.3 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Pkinase PF00069.25 KPI90463.1 - 1.1e-41 142.9 0.0 7.7e-41 140.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90463.1 - 8.8e-26 90.7 0.0 7.5e-23 81.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase PQQ PF01011.21 KPI90463.1 - 0.00034 20.4 0.0 0.00094 19.0 0.0 1.8 1 0 0 1 1 1 1 PQQ enzyme repeat PQQ_2 PF13360.6 KPI90463.1 - 0.076 12.6 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 PQQ-like domain OGG_N PF07934.12 KPI90465.1 - 3e-25 88.7 0.0 6.3e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 KPI90465.1 - 8e-11 42.4 0.0 1.1e-07 32.3 0.0 2.3 2 0 0 2 2 2 2 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KPI90465.1 - 0.00051 19.8 0.0 0.016 15.1 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_2 PF12826.7 KPI90465.1 - 0.065 13.3 0.0 6.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif PXA PF02194.15 KPI90466.1 - 0.044 13.8 0.7 0.19 11.7 0.3 2.3 2 0 0 2 2 2 0 PXA domain Pkinase PF00069.25 KPI90467.1 - 2.1e-50 171.6 0.0 3e-25 89.1 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90467.1 - 4.1e-29 101.7 0.0 7.2e-15 55.0 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase DSPc PF00782.20 KPI90467.1 - 2.3e-26 92.2 0.0 4.4e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 KPI90467.1 - 7.4e-08 32.0 9.0 7.9e-05 22.4 1.0 3.6 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 KPI90467.1 - 1.7e-07 31.4 6.5 0.00085 19.7 0.3 4.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) Y_phosphatase PF00102.27 KPI90467.1 - 0.0016 18.0 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_1 PF00560.33 KPI90467.1 - 4.4 8.2 4.5 1.6e+02 3.5 0.0 4.4 3 1 0 3 3 3 0 Leucine Rich Repeat Thioredoxin PF00085.20 KPI90469.1 - 3.5e-25 88.0 0.0 2e-24 85.6 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 KPI90469.1 - 2e-07 31.4 0.1 1.1e-05 25.8 0.1 2.9 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KPI90469.1 - 4.7e-05 23.6 0.0 0.0013 19.0 0.0 2.7 2 1 1 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 KPI90469.1 - 0.002 18.0 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KPI90469.1 - 0.0031 17.2 0.0 0.0089 15.8 0.0 1.8 1 0 0 1 1 1 1 Redoxin OST3_OST6 PF04756.13 KPI90469.1 - 0.0038 16.6 0.0 0.0066 15.8 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 KPI90469.1 - 0.0065 16.6 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KPI90469.1 - 0.021 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 KPI90469.1 - 0.058 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 KPI90469.1 - 0.09 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin CorA PF01544.18 KPI90470.1 - 9.1e-08 31.8 0.2 3.9e-07 29.7 0.1 1.9 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Staygreen PF12638.7 KPI90470.1 - 0.15 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Staygreen protein Exo_endo_phos PF03372.23 KPI90472.1 - 9.8e-16 58.0 0.0 1.2e-14 54.4 0.0 2.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4500 PF14937.6 KPI90473.1 - 0.42 10.6 1.5 0.46 10.5 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) Glyco_hydro_65m PF03632.15 KPI90474.1 - 2.7e-37 128.6 0.0 4.1e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 KPI90474.1 - 4.6e-11 42.5 0.1 9.3e-11 41.5 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain Hepatitis_core PF00906.20 KPI90474.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Hepatitis core antigen Kelch_3 PF13415.6 KPI90475.1 - 3e-12 46.5 14.9 2.8e-05 24.3 0.0 7.6 9 0 0 9 9 9 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KPI90475.1 - 4.7e-11 42.5 3.3 0.00025 21.0 0.0 5.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KPI90475.1 - 6.1e-09 35.3 12.8 2.2e-07 30.4 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 KPI90475.1 - 1.6e-06 28.0 4.8 0.0028 17.6 0.3 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 KPI90475.1 - 0.00017 21.8 0.1 0.9 9.9 0.0 4.6 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 KPI90475.1 - 0.00039 20.3 4.3 0.066 13.2 0.1 5.2 6 0 0 6 6 6 1 Kelch motif HA2 PF04408.23 KPI90476.1 - 1.5e-17 63.8 0.0 3.4e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI90476.1 - 1.4e-11 44.7 0.0 8.7e-11 42.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KPI90476.1 - 3.7e-07 30.1 0.5 7.9e-07 29.0 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 KPI90476.1 - 4.9e-07 30.0 0.0 9.8e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.6 KPI90476.1 - 1.3e-06 28.8 0.1 2.7e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KPI90476.1 - 7.3e-05 22.6 0.0 0.00019 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KPI90476.1 - 0.00011 22.5 0.7 0.0006 20.1 0.1 2.4 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 KPI90476.1 - 0.00033 20.3 0.4 0.0018 17.9 0.1 2.3 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain ResIII PF04851.15 KPI90476.1 - 0.0029 17.6 0.0 3.1 7.8 0.0 2.2 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_16 PF13191.6 KPI90476.1 - 0.0053 17.2 0.4 0.13 12.6 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 KPI90476.1 - 0.015 14.9 0.0 0.65 9.6 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 KPI90476.1 - 0.016 14.3 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 KPI90476.1 - 0.02 15.4 0.0 0.33 11.5 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Helicase_RecD PF05127.14 KPI90476.1 - 0.021 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_23 PF13476.6 KPI90476.1 - 0.027 15.0 0.0 0.046 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KPI90476.1 - 0.028 14.0 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 KPI90476.1 - 0.034 14.1 0.1 0.24 11.3 0.1 2.3 1 1 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 KPI90476.1 - 0.034 13.9 0.2 0.33 10.7 0.0 2.2 1 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KPI90476.1 - 0.081 12.7 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 KPI90476.1 - 0.14 11.5 0.4 0.95 8.8 0.0 2.2 3 0 0 3 3 3 0 Bacterial TniB protein DUF2075 PF09848.9 KPI90476.1 - 0.18 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Dynamin_N PF00350.23 KPI90477.1 - 8.4e-15 55.2 0.0 2.2e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 Dynamin family DUF5600 PF18150.1 KPI90477.1 - 5.2e-12 46.3 0.1 1.3e-11 45.1 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) MMR_HSR1 PF01926.23 KPI90477.1 - 7.7e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EHD_N PF16880.5 KPI90477.1 - 5.3e-05 23.0 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 N-terminal EH-domain containing protein RsgA_GTPase PF03193.16 KPI90477.1 - 0.13 12.2 0.0 3.1 7.7 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase CopG_antitoxin PF12441.8 KPI90477.1 - 0.23 12.0 0.0 0.23 12.0 0.0 2.0 2 0 0 2 2 2 0 CopG antitoxin of type II toxin-antitoxin system Cofilin_ADF PF00241.20 KPI90479.1 - 7.2e-19 67.8 0.1 1.8e-11 43.9 0.1 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein EccE PF11203.8 KPI90480.1 - 5.7 7.3 8.7 1 9.7 0.1 3.2 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE MMgT PF10270.9 KPI90482.1 - 0.0079 16.5 0.4 0.011 16.1 0.4 1.4 1 1 0 1 1 1 1 Membrane magnesium transporter K1 PF02960.14 KPI90482.1 - 0.049 13.8 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 K1 glycoprotein DUF2583 PF10762.9 KPI90482.1 - 0.093 13.2 0.5 0.2 12.1 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2583) Clat_adaptor_s PF01217.20 KPI90483.1 - 3.6e-46 156.6 3.1 3.9e-46 156.5 3.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain tRNA-synt_2 PF00152.20 KPI90484.1 - 4.5e-86 288.8 0.0 6.6e-86 288.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_synt_1c_R1 PF04558.15 KPI90484.1 - 2.1e-34 118.9 0.7 3.7e-34 118.1 0.7 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_anti-codon PF01336.25 KPI90484.1 - 4.5e-09 36.2 0.0 8.7e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2046 PF09755.9 KPI90486.1 - 9.5e-07 28.3 28.0 1.2e-05 24.7 15.9 3.0 2 1 1 3 3 3 3 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 KPI90486.1 - 0.00084 19.6 3.4 0.00084 19.6 3.4 3.0 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) TMPIT PF07851.13 KPI90486.1 - 0.0044 16.3 13.6 0.22 10.8 0.5 2.1 2 0 0 2 2 2 2 TMPIT-like protein APG6_N PF17675.1 KPI90486.1 - 0.02 15.4 0.6 0.02 15.4 0.6 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region Atg14 PF10186.9 KPI90486.1 - 0.049 12.7 17.0 0.011 14.8 6.6 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 NYD-SP28_assoc PF14775.6 KPI90486.1 - 0.61 10.2 11.1 5.4 7.2 0.1 3.9 3 1 0 3 3 3 0 Sperm tail C-terminal domain THOC7 PF05615.13 KPI90486.1 - 1 9.7 18.5 3.8 7.8 0.2 2.9 2 1 0 2 2 2 0 Tho complex subunit 7 DUF1664 PF07889.12 KPI90486.1 - 2.7 8.1 9.3 6 6.9 2.1 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 KPI90486.1 - 3.3 7.0 12.8 2.9 7.2 5.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ERM PF00769.19 KPI90486.1 - 3.3 7.5 32.6 0.21 11.4 4.6 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Exonuc_VII_L PF02601.15 KPI90486.1 - 4.8 6.7 18.9 2.8 7.4 9.9 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit CBFD_NFYB_HMF PF00808.23 KPI90487.1 - 0.00047 20.4 0.2 0.00093 19.4 0.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone EF-hand_7 PF13499.6 KPI90489.1 - 1.2e-23 83.4 5.7 1e-15 57.9 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KPI90489.1 - 4.8e-22 75.8 6.6 1.8e-07 30.2 1.4 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KPI90489.1 - 1.4e-18 65.2 3.6 3.5e-06 26.5 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KPI90489.1 - 1.9e-15 56.4 5.5 1.8e-11 43.7 0.8 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 KPI90489.1 - 1.2e-12 48.0 0.3 1.2e-06 28.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KPI90489.1 - 3.8e-12 45.1 4.9 0.00032 20.1 1.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 KPI90489.1 - 8.9e-07 28.8 0.6 0.0027 17.6 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KPI90489.1 - 0.00056 19.9 0.0 0.3 11.0 0.0 3.0 2 1 1 3 3 3 1 Caleosin related protein DUF3164 PF11363.8 KPI90489.1 - 0.0088 15.7 0.3 0.084 12.5 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3164) EF-hand_14 PF17959.1 KPI90489.1 - 0.012 15.9 1.6 0.36 11.2 0.3 2.3 2 0 0 2 2 2 0 EF-hand domain MgtE_N PF03448.17 KPI90489.1 - 0.02 15.5 2.7 0.042 14.5 0.6 2.2 2 0 0 2 2 2 0 MgtE intracellular N domain Dockerin_1 PF00404.18 KPI90489.1 - 0.083 13.1 0.2 0.23 11.7 0.2 1.7 1 1 0 1 1 1 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KPI90489.1 - 0.085 13.2 1.4 1 9.7 0.3 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KPI90489.1 - 0.2 12.6 0.7 0.51 11.2 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain SurA_N_2 PF13623.6 KPI90489.1 - 0.36 10.7 3.8 0.75 9.7 0.5 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Aminotran_4 PF01063.19 KPI90491.1 - 9.8e-30 104.1 0.0 1.3e-29 103.7 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Glycos_transf_1 PF00534.20 KPI90492.1 - 3.3e-29 101.6 0.0 7.2e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KPI90492.1 - 1.5e-14 54.6 0.1 9.3e-14 52.0 0.0 2.2 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KPI90492.1 - 1e-06 28.8 0.0 2.4e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 KPI90492.1 - 0.0057 17.0 0.0 0.023 15.1 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 DnaJ PF00226.31 KPI90493.1 - 6.9e-19 67.7 0.3 1.7e-18 66.5 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.28 KPI90493.1 - 5.9e-17 60.7 14.3 7e-05 22.5 0.1 6.9 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90493.1 - 2.7e-13 48.9 22.1 0.00023 21.1 0.5 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 KPI90493.1 - 3.9e-08 32.9 11.7 0.0095 16.1 0.1 6.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI90493.1 - 2.2e-05 24.6 1.7 2.2e-05 24.6 1.7 4.5 5 1 0 6 6 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 KPI90493.1 - 0.00018 21.7 0.1 6.6 7.4 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KPI90493.1 - 0.00038 20.9 11.2 7.3 7.2 0.0 6.0 3 2 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI90493.1 - 0.0019 18.1 11.0 0.83 9.8 0.4 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI90493.1 - 0.0021 18.7 21.5 0.05 14.3 1.0 5.9 6 0 0 6 6 5 1 Tetratricopeptide repeat Rapsyn_N PF10579.9 KPI90493.1 - 0.0053 16.8 0.4 0.064 13.4 0.0 2.8 2 1 1 3 3 3 1 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.6 KPI90493.1 - 0.0091 16.7 9.3 1.7 9.6 0.9 6.0 4 1 2 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KPI90493.1 - 0.013 15.2 10.8 1.3 8.8 0.0 4.3 4 1 0 4 4 4 0 TPR repeat SHNi-TPR PF10516.9 KPI90493.1 - 0.11 12.0 0.3 54 3.3 0.1 4.0 3 1 0 3 3 3 0 SHNi-TPR TPR_6 PF13174.6 KPI90493.1 - 0.17 12.6 10.3 4.3 8.2 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat eIF-5_eIF-2B PF01873.17 KPI90493.1 - 0.54 10.2 2.7 0.38 10.6 0.7 1.8 2 0 0 2 2 1 0 Domain found in IF2B/IF5 ANAPC3 PF12895.7 KPI90493.1 - 0.87 9.9 0.0 0.87 9.9 0.0 4.2 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KPI90493.1 - 0.91 9.7 8.0 9.5 6.5 3.8 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KPI90493.1 - 1.9 8.4 9.0 3.5 7.6 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat C1_1 PF00130.22 KPI90494.1 - 0.097 12.6 1.5 0.13 12.2 0.5 1.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Sec7 PF01369.20 KPI90495.1 - 3.7e-48 163.6 0.0 6.3e-48 162.9 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KPI90495.1 - 1.8e-07 31.2 0.0 9.7e-07 28.8 0.0 2.3 1 1 1 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal GTP_EFTU PF00009.27 KPI90496.1 - 2.2e-06 27.3 0.0 1e-05 25.2 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 KPI90496.1 - 0.0058 17.1 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 KPI90496.1 - 0.02 14.8 0.1 0.39 10.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase PipA PF07108.11 KPI90496.1 - 0.084 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 PipA protein Ribosomal_L35Ae PF01247.18 KPI90497.1 - 2.1e-33 114.3 0.8 3.4e-33 113.7 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 KPI90497.1 - 4.9e-06 26.7 0.5 0.052 13.8 0.0 2.4 2 1 0 2 2 2 2 RimM N-terminal domain DUF4115 PF13464.6 KPI90497.1 - 0.037 14.2 0.0 0.08 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) HemY_N PF07219.13 KPI90498.1 - 0.021 15.0 2.3 1.2 9.4 0.5 2.1 1 1 1 2 2 2 0 HemY protein N-terminus DUF2721 PF11026.8 KPI90498.1 - 0.033 14.1 0.1 0.059 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF4637 PF15470.6 KPI90500.1 - 0.12 12.1 0.1 0.7 9.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) ATG16 PF08614.11 KPI90501.1 - 0.00027 21.2 20.5 0.00027 21.2 20.5 8.2 2 2 4 7 7 7 3 Autophagy protein 16 (ATG16) DUF3502 PF12010.8 KPI90501.1 - 2.8 8.6 10.4 4.4 8.0 0.3 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3502) LRR_6 PF13516.6 KPI90502.1 - 1.6e-05 24.6 5.8 0.088 12.9 0.1 3.5 4 0 0 4 4 4 2 Leucine Rich repeat LRR_8 PF13855.6 KPI90502.1 - 0.18 11.6 2.7 17 5.3 0.0 3.0 3 0 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.33 KPI90502.1 - 0.34 11.6 2.6 8.4 7.4 0.2 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 KPI90502.1 - 3.3 8.3 5.0 35 5.0 0.3 3.2 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) ANAPC4_WD40 PF12894.7 KPI90503.1 - 1.4e-05 25.3 0.0 0.17 12.2 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KPI90503.1 - 1.6 9.7 7.4 11 7.1 0.1 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat PP2C PF00481.21 KPI90504.1 - 1.3e-53 182.3 0.0 1.6e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KPI90504.1 - 0.0042 16.8 1.0 0.0098 15.5 1.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 KPI90505.1 - 2.8e-59 200.9 0.0 3.5e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KPI90505.1 - 0.028 14.1 0.0 0.048 13.3 0.0 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C Sec7 PF01369.20 KPI90506.1 - 4e-48 163.5 0.0 3.4e-47 160.5 0.0 2.3 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 KPI90506.1 - 5.4e-20 71.9 3.3 5.8e-20 71.8 0.8 2.4 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 KPI90506.1 - 3.3e-17 62.1 0.0 8.5e-17 60.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1981) Fez1 PF06818.15 KPI90507.1 - 0.0059 17.1 2.2 0.0059 17.1 2.2 3.8 1 1 3 4 4 4 2 Fez1 Fib_alpha PF08702.10 KPI90507.1 - 0.0084 16.3 27.8 0.017 15.3 9.7 3.8 1 1 3 4 4 4 2 Fibrinogen alpha/beta chain family Sec63 PF02889.16 KPI90507.1 - 0.046 12.9 2.8 0.077 12.1 2.8 1.3 1 0 0 1 1 1 0 Sec63 Brl domain DUF948 PF06103.11 KPI90507.1 - 0.049 13.9 18.8 2.2 8.6 0.2 4.9 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.6 KPI90507.1 - 0.058 12.0 32.1 0.076 11.6 10.1 2.2 1 1 1 2 2 2 0 AAA domain EzrA PF06160.12 KPI90507.1 - 0.085 11.0 38.0 0.055 11.6 18.0 3.0 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Jnk-SapK_ap_N PF09744.9 KPI90507.1 - 0.11 12.8 51.6 0.092 13.0 5.4 3.8 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Strep_SA_rep PF06696.11 KPI90507.1 - 0.12 12.4 3.4 0.8 9.8 0.2 3.2 2 0 0 2 2 2 0 Streptococcal surface antigen repeat ATG16 PF08614.11 KPI90507.1 - 0.15 12.3 54.4 12 6.1 35.6 3.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FliD_N PF02465.18 KPI90507.1 - 0.37 11.5 19.5 0.31 11.8 0.4 4.4 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Mod_r PF07200.13 KPI90507.1 - 0.45 10.6 41.3 0.04 14.0 3.5 4.1 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein TMF_DNA_bd PF12329.8 KPI90507.1 - 0.5 10.4 48.1 0.99 9.5 0.7 6.0 3 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding TACC_C PF05010.14 KPI90507.1 - 0.5 10.1 39.1 0.081 12.7 25.2 2.6 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FlxA PF14282.6 KPI90507.1 - 1.2 9.1 36.6 1 9.4 1.8 4.3 1 1 3 4 4 4 0 FlxA-like protein Prefoldin PF02996.17 KPI90507.1 - 1.6 8.7 34.6 0.76 9.7 3.9 6.4 2 1 4 7 7 7 0 Prefoldin subunit Lebercilin PF15619.6 KPI90507.1 - 1.6 8.4 51.5 0.21 11.2 0.4 3.9 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Rab5-bind PF09311.11 KPI90507.1 - 1.9 7.8 42.4 0.078 12.4 14.6 3.4 1 1 1 3 3 3 0 Rabaptin-like protein APG6_N PF17675.1 KPI90507.1 - 2.7 8.5 60.0 8.8 6.9 24.5 3.3 1 1 2 3 3 3 0 Apg6 coiled-coil region Spc7 PF08317.11 KPI90507.1 - 3 6.6 48.5 0.21 10.4 22.1 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein TMPIT PF07851.13 KPI90507.1 - 3.6 6.7 28.8 0.29 10.3 7.4 3.7 1 1 3 4 4 4 0 TMPIT-like protein Rootletin PF15035.6 KPI90507.1 - 3.7 7.5 46.5 0.077 13.0 24.4 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF4201 PF13870.6 KPI90507.1 - 3.9 7.2 41.9 0.2 11.4 12.8 4.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) SH3BP5 PF05276.14 KPI90507.1 - 4 7.2 32.8 3.8 7.3 6.5 3.9 2 2 1 3 3 3 0 SH3 domain-binding protein 5 (SH3BP5) FAM76 PF16046.5 KPI90507.1 - 7.2 5.9 35.9 3.1 7.1 17.7 3.0 1 1 2 3 3 3 0 FAM76 protein DUF3037 PF11236.8 KPI90507.1 - 7.7 7.0 16.9 0.29 11.6 2.1 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) YvrJ PF12841.7 KPI90507.1 - 8.4 6.0 5.4 24 4.5 0.0 3.7 3 1 1 4 4 4 0 YvrJ protein family HemX PF04375.14 KPI90507.1 - 8.6 5.5 34.7 1.5 8.0 12.2 3.3 1 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase CorA PF01544.18 KPI90507.1 - 8.8 5.5 34.3 1.9 7.7 12.3 3.2 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein CEP209_CC5 PF16574.5 KPI90508.1 - 0.0072 16.5 0.7 0.0072 16.5 0.7 2.3 2 0 0 2 2 2 1 Coiled-coil region of centrosome protein CE290 TPR_MLP1_2 PF07926.12 KPI90508.1 - 0.023 14.8 3.0 0.023 14.8 3.0 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.5 KPI90508.1 - 0.025 15.5 1.6 0.025 15.5 1.6 2.2 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain CortBP2 PF09727.9 KPI90508.1 - 0.099 12.5 12.7 0.29 11.0 0.6 3.5 2 1 2 4 4 4 0 Cortactin-binding protein-2 Seadorna_VP6 PF07407.11 KPI90508.1 - 0.22 10.4 0.6 0.32 9.9 0.6 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein HIP1_clath_bdg PF16515.5 KPI90508.1 - 1.2 9.8 11.4 7.6 7.2 0.5 3.8 3 1 1 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BLOC1_2 PF10046.9 KPI90509.1 - 0.0098 16.2 0.5 0.0098 16.2 0.5 5.6 5 1 1 6 6 6 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 KPI90509.1 - 0.5 10.6 29.6 1.6 8.9 0.5 4.7 3 2 2 5 5 5 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 KPI90509.1 - 1.4 8.8 28.3 0.12 12.2 1.0 6.7 6 2 1 7 7 7 0 GIT coiled-coil Rho guanine nucleotide exchange factor CdvA PF18822.1 KPI90509.1 - 2.1 8.2 32.7 0.14 12.0 3.7 5.8 4 2 2 6 6 6 0 CdvA-like coiled-coil domain SAC3 PF12209.8 KPI90509.1 - 3.1 8.1 5.8 2.2 8.5 0.3 3.3 3 0 0 3 3 3 0 Leucine permease transcriptional regulator helical domain Sec8_exocyst PF04048.14 KPI90509.1 - 4.1 7.3 18.9 3.2 7.6 0.8 4.4 4 0 0 4 4 4 0 Sec8 exocyst complex component specific domain TPR_MLP1_2 PF07926.12 KPI90509.1 - 4.8 7.3 61.1 0.096 12.8 11.5 5.8 4 1 0 5 5 5 0 TPR/MLP1/MLP2-like protein C2 PF00168.30 KPI90510.1 - 1.5e-05 25.2 0.0 3.5e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain Lebercilin PF15619.6 KPI90510.1 - 0.0004 20.1 13.0 0.0004 20.1 13.0 6.7 4 1 2 6 6 6 2 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.12 KPI90510.1 - 0.00049 20.2 8.8 0.00049 20.2 8.8 7.8 6 2 1 7 7 5 3 TPR/MLP1/MLP2-like protein Shugoshin_N PF07558.11 KPI90510.1 - 0.0041 16.9 15.0 4.5 7.2 0.8 6.8 6 0 0 6 6 6 1 Shugoshin N-terminal coiled-coil region CENP-H PF05837.12 KPI90510.1 - 0.017 15.6 6.1 0.017 15.6 6.1 7.1 4 3 4 8 8 8 0 Centromere protein H (CENP-H) Surfac_D-trimer PF09006.11 KPI90510.1 - 0.029 14.2 3.7 0.059 13.3 0.3 3.2 4 0 0 4 4 3 0 Lung surfactant protein D coiled-coil trimerisation NPV_P10 PF05531.12 KPI90510.1 - 0.055 13.9 21.5 1.2 9.7 0.4 7.0 7 1 1 8 8 8 0 Nucleopolyhedrovirus P10 protein TSC22 PF01166.18 KPI90510.1 - 0.061 13.7 0.1 0.061 13.7 0.1 9.4 11 2 0 12 12 8 0 TSC-22/dip/bun family DASH_Dam1 PF08653.10 KPI90510.1 - 0.08 12.8 7.3 5.7 6.8 0.1 4.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 FlaC_arch PF05377.11 KPI90510.1 - 0.11 13.0 0.2 0.11 13.0 0.2 7.8 7 2 2 9 9 9 0 Flagella accessory protein C (FlaC) HEPN_AbiA_CTD PF18732.1 KPI90510.1 - 0.13 12.2 0.3 51 3.8 0.0 3.6 4 0 0 4 4 4 0 HEPN like, Abia C-terminal domain Fez1 PF06818.15 KPI90510.1 - 0.23 11.9 79.2 0.03 14.8 21.0 5.3 3 1 1 4 4 2 0 Fez1 Pox_A_type_inc PF04508.12 KPI90510.1 - 2.4 8.2 27.8 0.52 10.3 1.5 6.0 5 0 0 5 5 4 0 Viral A-type inclusion protein repeat DUF3573 PF12097.8 KPI90510.1 - 2.6 6.8 15.2 0.5 9.1 0.2 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3573) DUF5082 PF16888.5 KPI90510.1 - 3.6 7.9 45.2 0.1 12.9 0.5 7.0 4 2 3 7 7 7 0 Domain of unknown function (DUF5082) Laminin_II PF06009.12 KPI90510.1 - 3.9 7.5 50.3 0.072 13.1 3.8 7.8 2 2 4 8 8 8 0 Laminin Domain II Abi_C PF14355.6 KPI90510.1 - 4.1 7.6 7.8 0.95 9.6 0.5 3.6 3 0 0 3 3 3 0 Abortive infection C-terminus DUF3138 PF11336.8 KPI90510.1 - 4.6 5.8 19.6 2.3 6.7 7.3 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3138) Fib_alpha PF08702.10 KPI90510.1 - 8.6 6.5 44.1 0.043 14.0 1.1 7.1 5 3 1 6 6 6 0 Fibrinogen alpha/beta chain family Val_tRNA-synt_C PF10458.9 KPI90510.1 - 8.8 6.7 30.2 0.055 13.8 1.9 6.6 4 2 0 4 4 4 0 Valyl tRNA synthetase tRNA binding arm IFT57 PF10498.9 KPI90511.1 - 0.042 12.8 0.2 0.097 11.6 0.2 1.5 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 PMEI PF04043.15 KPI90511.1 - 0.1 12.9 0.1 0.1 12.9 0.1 2.1 2 1 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor DUF4094 PF13334.6 KPI90511.1 - 0.14 12.6 5.5 0.81 10.2 0.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) BRCC36_C PF18110.1 KPI90512.1 - 0.018 15.2 0.0 0.018 15.2 0.0 2.6 3 0 0 3 3 3 0 BRCC36 C-terminal helical domain DUF3584 PF12128.8 KPI90512.1 - 0.022 12.3 15.8 0.025 12.1 15.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PIN_9 PF18477.1 KPI90512.1 - 0.55 10.5 2.7 0.61 10.4 0.5 2.2 2 0 0 2 2 2 0 PIN like domain HIP1_clath_bdg PF16515.5 KPI90512.1 - 0.75 10.4 19.0 0.28 11.8 5.4 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YlqD PF11068.8 KPI90512.1 - 7 7.0 16.6 0.13 12.7 2.7 2.4 2 0 0 2 2 2 0 YlqD protein DUF4407 PF14362.6 KPI90512.1 - 9.6 5.5 10.4 14 4.9 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DnaJ_C PF01556.18 KPI90513.1 - 5.1e-38 130.5 0.0 7e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KPI90513.1 - 1.9e-26 91.9 6.4 3.3e-26 91.2 6.4 1.4 1 0 0 1 1 1 1 DnaJ domain Ras PF00071.22 KPI90514.1 - 7.5e-45 152.4 0.3 9.5e-45 152.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI90514.1 - 2e-29 102.2 0.1 3.2e-29 101.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI90514.1 - 1.7e-06 27.6 0.0 2.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KPI90514.1 - 0.0015 18.6 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI90514.1 - 0.034 13.7 0.0 7.4 6.1 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Gtr1_RagA PF04670.12 KPI90514.1 - 0.055 12.8 0.0 0.084 12.2 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 KPI90514.1 - 0.056 13.2 0.0 3.1 7.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 KPI90514.1 - 0.099 12.5 0.1 0.73 9.7 0.0 2.1 2 1 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 KPI90515.1 - 0.00044 20.5 0.1 0.00096 19.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain DAP3 PF10236.9 KPI90515.1 - 0.038 13.1 0.2 0.08 12.1 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.27 KPI90515.1 - 0.064 13.8 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KPI90515.1 - 0.1 12.9 0.2 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 KPI90515.1 - 0.1 12.8 0.0 0.74 10.0 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Sigma54_activat PF00158.26 KPI90515.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain MMR_HSR1 PF01926.23 KPI90515.1 - 0.17 12.0 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 KPI90515.1 - 0.19 11.5 0.4 0.39 10.5 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 KPI90516.1 - 2.6e-59 199.6 0.0 2.9e-59 199.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI90516.1 - 1.5e-12 47.8 0.0 2e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KPI90516.1 - 9.7e-12 44.7 0.2 3.3e-08 33.1 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KPI90516.1 - 2.4e-10 40.2 0.0 2.8e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KPI90516.1 - 2.9e-10 39.9 0.0 3.6e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KPI90516.1 - 4.4e-10 39.3 0.0 5.5e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KPI90516.1 - 7.9e-08 32.4 0.0 1.1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Thioredoxin_2 PF13098.6 KPI90516.1 - 0.0069 16.8 0.0 0.0096 16.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain AAA_16 PF13191.6 KPI90516.1 - 0.015 15.7 0.0 0.02 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KPI90516.1 - 0.018 14.9 0.0 6.2 6.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 KPI90516.1 - 0.029 13.9 0.0 0.085 12.4 0.0 1.7 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KPI90516.1 - 0.049 13.2 0.1 1.7 8.2 0.1 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 KPI90516.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 KPI90516.1 - 0.09 12.8 0.0 8.9 6.3 0.0 2.1 2 0 0 2 2 2 0 Dynamin family Vps54 PF07928.12 KPI90518.1 - 4.4e-22 78.9 0.4 8.7e-21 74.8 0.2 2.9 2 1 0 2 2 2 1 Vps54-like protein GCN5L1 PF06320.13 KPI90518.1 - 0.017 15.3 0.0 0.066 13.4 0.0 2.0 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) His_Phos_1 PF00300.22 KPI90518.1 - 0.035 13.8 0.1 0.079 12.6 0.1 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) Surface_antigen PF11054.8 KPI90519.1 - 0.014 15.1 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen Suc_Fer-like PF06999.12 KPI90521.1 - 2.7e-28 99.2 0.0 3.5e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like NUP50 PF08911.11 KPI90522.1 - 0.0016 19.1 31.8 0.01 16.5 27.6 3.9 2 1 0 2 2 2 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 KPI90522.1 - 0.0048 17.1 0.1 0.013 15.7 0.0 1.8 2 0 0 2 2 2 1 RanBP1 domain Fis1_TPR_C PF14853.6 KPI90523.1 - 4.4e-05 23.5 0.8 4.4e-05 23.5 0.8 1.9 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 KPI90523.1 - 0.044 13.6 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat zf_C2HC_14 PF18574.1 KPI90525.1 - 0.072 12.9 0.9 0.15 11.9 0.9 1.5 1 0 0 1 1 1 0 C2HC Zing finger domain DUF2570 PF10828.8 KPI90525.1 - 1.3 8.8 5.6 0.33 10.8 1.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) ATP_bind_3 PF01171.20 KPI90526.1 - 5.6e-17 62.1 0.0 1e-16 61.2 0.0 1.4 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 KPI90526.1 - 8.7e-14 50.7 1.6 8.7e-14 50.7 1.6 3.1 3 0 0 3 3 3 1 Zinc-ribbon PAPS_reduct PF01507.19 KPI90526.1 - 0.0074 16.3 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family TF_Zn_Ribbon PF08271.12 KPI90526.1 - 2.3 7.8 9.2 2.7 7.6 0.4 3.2 3 0 0 3 3 3 0 TFIIB zinc-binding SelK_SelG PF10961.8 KPI90527.1 - 0.036 14.7 10.9 0.6 10.8 10.9 2.1 1 1 0 1 1 1 0 Selenoprotein SelK_SelG PhoR PF11808.8 KPI90527.1 - 0.14 12.5 0.1 0.19 12.1 0.1 1.1 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR EF-hand_7 PF13499.6 KPI90528.1 - 7.5e-15 55.1 1.7 5.1e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KPI90528.1 - 9.9e-11 41.3 0.3 2.8e-05 23.9 0.4 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KPI90528.1 - 1e-10 40.7 3.1 0.00041 20.1 0.0 4.2 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KPI90528.1 - 6.3e-10 37.9 0.7 0.0021 17.5 0.0 4.3 4 1 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 KPI90528.1 - 7.3e-06 26.2 0.1 0.0066 16.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KPI90528.1 - 3.4e-05 23.1 0.2 0.013 15.0 0.1 3.0 3 0 0 3 3 3 2 EF hand TPR_14 PF13428.6 KPI90529.1 - 3.6e-06 27.3 10.9 0.6 11.1 0.1 5.6 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KPI90529.1 - 3.4e-05 24.4 21.9 0.14 12.8 0.4 5.6 5 1 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI90529.1 - 9.7e-05 22.5 2.6 13 6.1 0.2 5.2 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KPI90529.1 - 0.0013 19.2 12.7 0.59 10.7 0.0 6.1 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 KPI90529.1 - 0.009 16.3 12.9 1.4 9.2 0.2 5.5 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90529.1 - 0.011 15.8 14.4 12 6.3 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat PknG_TPR PF16918.5 KPI90529.1 - 0.012 14.4 1.1 4.1 6.0 0.1 3.0 3 0 0 3 3 3 0 Protein kinase G tetratricopeptide repeat PPR PF01535.20 KPI90529.1 - 0.015 15.5 0.0 32 5.1 0.0 3.7 3 0 0 3 3 3 0 PPR repeat TPR_6 PF13174.6 KPI90529.1 - 0.073 13.7 8.7 4.3 8.2 0.1 6.0 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KPI90529.1 - 0.088 12.7 1.1 10 6.1 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KPI90529.1 - 0.33 11.7 7.6 36 5.4 0.2 5.3 4 0 0 4 4 4 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KPI90529.1 - 1.8 8.3 5.1 3.3 7.4 0.1 3.7 5 1 0 5 5 5 0 Bacterial type III secretion protein (HrpB1_HrpK) ABC1 PF03109.16 KPI90530.1 - 1.2e-27 96.5 0.0 2.8e-27 95.3 0.0 1.7 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 KPI90530.1 - 2.8e-07 30.2 0.0 0.0023 17.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90530.1 - 1.6e-06 27.6 0.1 0.0021 17.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KPI90530.1 - 0.00016 21.7 0.1 0.00041 20.4 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KPI90530.1 - 0.00052 19.7 0.0 0.00086 19.0 0.0 1.3 1 0 0 1 1 1 1 RIO1 family NanE PF04131.14 KPI90530.1 - 0.021 14.0 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase UBM PF14377.6 KPI90530.1 - 0.13 11.7 1.4 0.26 10.8 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin binding region RabGAP-TBC PF00566.18 KPI90532.1 - 3.7e-59 200.0 0.0 4.8e-59 199.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RabGAP-TBC PF00566.18 KPI90533.1 - 4.2e-57 193.2 0.0 6e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MIF4G PF02854.19 KPI90535.1 - 4.3e-21 75.5 0.3 3e-20 72.8 0.0 2.3 2 1 0 2 2 2 1 MIF4G domain LMBR1 PF04791.16 KPI90535.1 - 0.068 12.1 0.3 0.13 11.2 0.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein COG2 PF06148.11 KPI90537.1 - 1.2e-37 128.9 0.0 3e-37 127.7 0.0 1.7 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 KPI90537.1 - 4.8e-29 101.3 0.1 1.4e-28 99.8 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) TLC PF03219.14 KPI90537.1 - 0.27 9.9 0.0 0.42 9.3 0.0 1.2 1 0 0 1 1 1 0 TLC ATP/ADP transporter FAP206 PF12018.8 KPI90538.1 - 5.6e-14 52.3 11.0 3e-05 23.7 0.0 6.3 7 0 0 7 7 7 4 Domain of unknown function YHS PF04945.13 KPI90538.1 - 1.8e-13 50.3 0.0 0.0014 18.7 0.2 5.4 5 0 0 5 5 5 4 YHS domain AAA_18 PF13238.6 KPI90538.1 - 0.003 18.1 0.3 0.2 12.2 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KPI90538.1 - 0.043 14.2 1.0 50 4.3 0.4 4.8 4 1 0 4 4 4 0 AAA domain AAA_33 PF13671.6 KPI90538.1 - 0.053 13.7 5.0 1.3 9.2 0.0 4.0 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KPI90538.1 - 0.067 13.6 0.0 0.067 13.6 0.0 6.0 7 1 1 8 8 8 0 AAA ATPase domain APS_kinase PF01583.20 KPI90538.1 - 0.11 12.3 0.0 6 6.7 0.0 2.8 2 0 0 2 2 2 0 Adenylylsulphate kinase OTU PF02338.19 KPI90539.1 - 0.00051 20.5 0.0 0.00092 19.7 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Matrilin_ccoil PF10393.9 KPI90541.1 - 0.68 9.8 3.6 8.2 6.4 0.4 3.1 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF2228 PF10228.9 KPI90541.1 - 2.3 7.9 4.5 0.85 9.3 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) RRM_1 PF00076.22 KPI90543.1 - 0.0007 19.4 0.4 0.0025 17.6 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.9 KPI90543.1 - 0.0079 15.1 3.0 0.013 14.4 3.0 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain Me-amine-dh_L PF02975.14 KPI90543.1 - 0.14 12.6 2.1 0.36 11.3 2.1 1.6 1 0 0 1 1 1 0 Methylamine dehydrogenase, L chain Tmemb_185A PF10269.9 KPI90544.1 - 0.00036 20.3 6.2 0.00036 20.3 6.2 2.3 1 1 2 3 3 3 3 Transmembrane Fragile-X-F protein 7TM_GPCR_Srz PF10325.9 KPI90544.1 - 0.052 12.9 8.5 0.11 11.8 1.8 2.3 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srz EphA2_TM PF14575.6 KPI90544.1 - 2.7 8.9 14.7 3.8 8.5 0.0 4.6 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Abhydrolase_9_N PF15420.6 KPI90544.1 - 3.5 7.6 6.7 26 4.7 0.0 3.0 2 1 1 3 3 3 0 Alpha/beta-hydrolase family N-terminus Pox_A14 PF05767.12 KPI90544.1 - 8.3 6.6 11.3 2.3 8.4 0.9 2.5 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF4996 PF16387.5 KPI90545.1 - 7.3e-29 100.3 0.1 2.7e-28 98.4 0.0 2.0 3 0 0 3 3 3 1 Domain of unknown function GDPD PF03009.17 KPI90545.1 - 3e-24 86.2 0.6 4.8e-24 85.5 0.3 1.4 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 KPI90545.1 - 0.012 15.2 0.1 0.022 14.3 0.1 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF5567 PF17722.1 KPI90546.1 - 2.7e-05 24.2 0.5 0.018 15.0 0.1 2.4 2 0 0 2 2 2 2 Family of unknown function (DUF5567) LmjF365940-deam PF14421.6 KPI90547.1 - 1.4e-38 132.4 0.2 5.5e-19 68.5 0.0 2.4 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Taxilin PF09728.9 KPI90548.1 - 0.11 11.7 51.5 0.16 11.1 51.5 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein KxDL PF10241.9 KPI90548.1 - 1.7 9.0 24.7 0.69 10.2 9.0 3.9 2 2 1 3 3 3 0 Uncharacterized conserved protein NPV_P10 PF05531.12 KPI90548.1 - 3.5 8.2 15.9 6.2 7.4 0.2 4.1 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3106 PF11304.8 KPI90550.1 - 0.0039 17.6 6.8 0.008 16.6 6.6 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3106) AAA_13 PF13166.6 KPI90550.1 - 1.6 7.3 12.0 2 7.0 12.0 1.0 1 0 0 1 1 1 0 AAA domain CDP-OH_P_transf PF01066.21 KPI90552.1 - 1.9e-17 63.7 0.0 1.9e-17 63.7 0.0 3.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PetG PF02529.15 KPI90552.1 - 0.01 15.6 0.3 2.1 8.3 0.0 3.2 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit 5 SIX1_SD PF16878.5 KPI90553.1 - 0.12 12.8 0.0 0.51 10.9 0.0 2.0 1 0 0 1 1 1 0 Transcriptional regulator, SIX1, N-terminal SD domain Gtr1_RagA PF04670.12 KPI90554.1 - 2.8e-66 223.2 0.0 3.7e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI90554.1 - 2.8e-06 27.4 0.0 5.8e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 KPI90554.1 - 2.7e-05 23.7 0.0 5.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KPI90554.1 - 0.00069 19.8 0.0 0.0014 18.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase YliH PF10799.8 KPI90554.1 - 0.028 14.3 0.4 0.077 12.9 0.1 2.0 2 0 0 2 2 2 0 Biofilm formation protein (YliH/bssR) SRPRB PF09439.10 KPI90554.1 - 0.034 13.6 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ras PF00071.22 KPI90554.1 - 0.073 12.7 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 Ras family Pro-rich_19 PF15455.6 KPI90554.1 - 0.085 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Proline-rich 19 DUF910 PF06014.11 KPI90554.1 - 0.11 12.5 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) AAA PF00004.29 KPI90556.1 - 3.6e-12 46.8 0.0 5e-05 23.7 0.0 2.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KPI90556.1 - 6.4e-05 23.0 0.0 0.00019 21.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI90556.1 - 0.0013 19.2 1.6 0.0085 16.5 0.1 3.0 3 1 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 KPI90556.1 - 0.0073 15.5 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Uroplakin_II PF07353.12 KPI90556.1 - 0.14 11.6 0.2 0.36 10.3 0.0 1.7 2 0 0 2 2 2 0 Uroplakin II HMG_box_2 PF09011.10 KPI90558.1 - 0.00068 20.2 1.6 0.02 15.5 0.0 2.7 2 2 0 2 2 2 1 HMG-box domain YABBY PF04690.13 KPI90558.1 - 0.034 14.7 0.3 0.042 14.4 0.3 1.2 1 0 0 1 1 1 0 YABBY protein S1FA PF04689.13 KPI90558.1 - 0.046 13.9 0.1 0.046 13.9 0.1 2.0 2 0 0 2 2 2 0 DNA binding protein S1FA HMG_box PF00505.19 KPI90558.1 - 0.048 14.1 3.1 0.058 13.8 0.2 2.5 2 1 0 2 2 2 0 HMG (high mobility group) box HMG_box PF00505.19 KPI90559.1 - 0.00027 21.3 3.9 0.0034 17.8 0.2 3.5 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KPI90559.1 - 0.0039 17.8 2.6 0.0099 16.5 0.2 2.8 2 2 0 2 2 2 1 HMG-box domain FAM176 PF14851.6 KPI90559.1 - 0.12 12.0 3.5 0.1 12.3 1.4 1.9 1 1 1 2 2 2 0 FAM176 family Nitroreductase PF00881.24 KPI90560.1 - 2.8e-14 53.5 0.1 3.5e-14 53.2 0.1 1.1 1 0 0 1 1 1 1 Nitroreductase family DUF5072 PF16807.5 KPI90560.1 - 0.13 12.4 0.1 0.28 11.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5072) LRR_8 PF13855.6 KPI90564.1 - 2.3e-07 30.4 2.4 0.00036 20.2 0.0 3.1 2 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 KPI90564.1 - 1.5e-06 28.4 3.8 0.033 14.6 0.0 3.4 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Gcd10p PF04189.13 KPI90565.1 - 4.8e-45 154.0 0.0 6.6e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family Wound_ind PF08186.11 KPI90566.1 - 2e-05 24.9 0.1 3.2e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Wound-inducible basic protein family COMMD1_N PF17221.3 KPI90566.1 - 0.12 12.7 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 COMMD1 N-terminal domain MS_channel PF00924.18 KPI90567.1 - 1.3e-17 64.0 0.8 1.6e-17 63.8 0.8 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel SpoIIIAC PF06686.11 KPI90567.1 - 0.59 10.4 2.9 8.1 6.7 0.1 2.5 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family RAB3GAP2_N PF14655.6 KPI90568.1 - 3.9e-12 46.1 0.0 6.2e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus TruD PF01142.18 KPI90569.1 - 2.9e-61 207.6 0.0 1.8e-59 201.7 0.0 2.8 2 1 0 2 2 2 1 tRNA pseudouridine synthase D (TruD) PhageMin_Tail PF10145.9 KPI90571.1 - 0.086 12.7 0.0 0.33 10.8 0.0 1.9 2 0 0 2 2 2 0 Phage-related minor tail protein Cullin_binding PF03556.15 KPI90572.1 - 1e-19 71.1 1.6 1.6e-19 70.5 1.6 1.3 1 0 0 1 1 1 1 Cullin binding MMR_HSR1 PF01926.23 KPI90573.1 - 0.011 15.8 0.0 0.04 14.0 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase FeoB_N PF02421.18 KPI90573.1 - 0.19 11.2 0.0 0.45 10.0 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Auxin_repressed PF05564.12 KPI90573.1 - 0.47 11.2 2.7 2.2 9.0 2.7 2.2 1 0 0 1 1 1 0 Dormancy/auxin associated protein CUE PF02845.16 KPI90574.1 - 0.028 14.1 0.0 0.065 12.9 0.0 1.6 1 0 0 1 1 1 0 CUE domain Phenol_monoox PF04663.12 KPI90576.1 - 0.051 13.7 0.9 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 Phenol hydroxylase conserved region HA2 PF04408.23 KPI90577.1 - 1.1e-16 61.0 0.5 2.6e-16 59.8 0.5 1.8 1 1 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KPI90577.1 - 1.7e-15 57.3 0.0 5.5e-15 55.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KPI90577.1 - 3.9e-15 56.0 0.0 9.3e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KPI90577.1 - 2.4e-09 37.2 0.0 4.5e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KPI90577.1 - 0.00039 20.7 0.3 0.0018 18.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 KPI90577.1 - 0.013 15.5 0.0 5.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KPI90577.1 - 0.014 15.7 0.5 0.056 13.8 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KPI90577.1 - 0.025 14.1 0.0 0.056 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 KPI90577.1 - 0.037 13.8 0.1 0.076 12.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KPI90577.1 - 0.047 13.1 0.0 0.13 11.7 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 KPI90577.1 - 0.051 12.6 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 KPI90577.1 - 0.088 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.27 KPI90577.1 - 0.093 13.2 0.0 0.37 11.3 0.0 2.0 1 0 0 1 1 1 0 ABC transporter DAO PF01266.24 KPI90578.1 - 2.8e-19 69.9 0.4 6.8e-12 45.6 0.1 3.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KPI90578.1 - 3.5e-07 30.4 0.3 1.2e-06 28.6 0.1 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KPI90578.1 - 5.1e-06 27.0 0.3 3.6e-05 24.2 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KPI90578.1 - 1.5e-05 24.4 0.1 0.00013 21.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KPI90578.1 - 0.00027 20.2 0.8 0.00099 18.3 0.4 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 KPI90578.1 - 0.0019 18.1 0.1 0.0036 17.2 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 KPI90578.1 - 0.0026 17.0 0.1 0.0026 17.0 0.1 1.9 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 KPI90578.1 - 0.0032 16.8 0.1 0.007 15.7 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 KPI90578.1 - 0.0045 16.1 0.3 0.0082 15.3 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KPI90578.1 - 0.0053 15.5 0.2 0.0083 14.9 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 KPI90578.1 - 0.0054 16.0 0.1 0.01 15.1 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KPI90578.1 - 0.016 14.5 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_2 PF03446.15 KPI90578.1 - 0.041 14.0 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Lycopene_cycl PF05834.12 KPI90578.1 - 0.079 12.0 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 KPI90578.1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF465 PF04325.13 KPI90579.1 - 0.058 13.4 1.0 0.058 13.4 1.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF465) Cyclin_N PF00134.23 KPI90580.1 - 0.0096 15.7 0.2 0.035 13.9 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain SWIM PF04434.17 KPI90581.1 - 0.31 10.8 3.8 0.64 9.7 3.8 1.5 1 0 0 1 1 1 0 SWIM zinc finger tRNA-synt_1 PF00133.22 KPI90582.1 - 8.5e-216 717.8 3.5 2e-215 716.6 0.1 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KPI90582.1 - 1.7e-22 80.0 0.0 4.1e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KPI90582.1 - 7.6e-12 44.7 3.2 0.00047 19.0 0.7 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) DHHW PF14286.6 KPI90582.1 - 0.03 13.7 0.1 0.073 12.4 0.0 1.6 2 0 0 2 2 2 0 DHHW protein tRNA-synt_1e PF01406.19 KPI90582.1 - 0.036 13.4 0.3 0.3 10.4 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain NERD PF08378.11 KPI90583.1 - 4.7e-16 59.2 0.3 2.9e-15 56.7 0.3 2.1 1 1 0 1 1 1 1 Nuclease-related domain BUD22 PF09073.10 KPI90584.1 - 0.26 10.6 1.5 2.4 7.4 0.0 2.2 2 0 0 2 2 2 0 BUD22 Adaptin_N PF01602.20 KPI90585.1 - 9.9e-74 248.8 0.4 1.4e-73 248.2 0.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KPI90585.1 - 3.9e-29 101.8 1.3 1.8e-28 99.6 0.3 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 KPI90585.1 - 7.3e-15 55.0 0.0 1.7e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 KPI90585.1 - 3.3e-09 37.0 2.7 0.00011 22.5 0.1 4.1 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 KPI90585.1 - 3.9e-08 32.9 3.3 0.33 11.3 0.1 6.3 7 0 0 7 7 7 2 HEAT repeat RasGEF_N_2 PF14663.6 KPI90585.1 - 0.001 19.4 1.2 0.24 11.8 0.3 3.2 1 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vitellogenin_N PF01347.22 KPI90585.1 - 0.019 13.4 0.0 0.032 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein amino terminal region HEAT_EZ PF13513.6 KPI90585.1 - 0.099 13.2 0.6 0.85 10.2 0.3 3.0 3 0 0 3 3 3 0 HEAT-like repeat CAP_C PF08603.11 KPI90586.1 - 1.7e-44 151.2 3.2 2.2e-44 150.9 3.2 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.19 KPI90586.1 - 1.5e-12 47.7 1.5 1.5e-12 47.7 1.5 1.4 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.12 KPI90586.1 - 3.4e-05 23.6 7.9 5.7e-05 22.8 7.9 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CpXC PF14353.6 KPI90586.1 - 0.0028 17.7 0.1 0.0066 16.5 0.1 1.7 1 0 0 1 1 1 1 CpXC protein DUF4988 PF16378.5 KPI90586.1 - 0.067 12.8 0.0 0.15 11.7 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function HrpB2 PF09487.10 KPI90587.1 - 0.027 14.9 0.0 0.077 13.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) Phage_int_SAM_1 PF02899.17 KPI90587.1 - 0.23 11.8 1.5 15 6.0 0.1 3.1 4 0 0 4 4 4 0 Phage integrase, N-terminal SAM-like domain EMP24_GP25L PF01105.24 KPI90588.1 - 4.2e-12 46.4 0.0 5e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_M24 PF00557.24 KPI90589.1 - 1.4e-28 100.1 0.1 1.7e-27 96.5 0.1 2.1 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.16 KPI90589.1 - 6.1e-08 32.4 0.0 1.5e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain KTI12 PF08433.10 KPI90591.1 - 0.03 13.8 0.4 0.27 10.7 0.0 2.1 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 KPI90591.1 - 0.1 13.0 3.8 0.2 12.0 0.2 2.4 2 1 0 2 2 2 0 AAA ATPase domain CBFB_NFYA PF02045.15 KPI90591.1 - 3.5 8.3 7.3 0.78 10.4 2.6 2.2 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B HlyIII PF03006.20 KPI90592.1 - 4.3e-56 190.1 25.9 5.4e-56 189.8 25.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related HlyIII PF03006.20 KPI90593.1 - 6.8e-48 163.3 29.8 8.6e-48 163.0 29.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related HlyIII PF03006.20 KPI90594.1 - 4.2e-52 177.1 31.8 5.6e-52 176.7 31.8 1.2 1 0 0 1 1 1 1 Haemolysin-III related HicB_lk_antitox PF15919.5 KPI90595.1 - 0.15 12.1 0.2 8.2 6.6 0.0 2.2 2 0 0 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system DUF1360 PF07098.11 KPI90596.1 - 0.04 13.8 0.0 1.7 8.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) DAO PF01266.24 KPI90598.1 - 2.6e-44 152.3 0.0 3.5e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KPI90598.1 - 0.0021 18.3 0.4 0.0089 16.2 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KPI90598.1 - 0.0045 16.3 0.1 0.39 9.9 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 KPI90598.1 - 0.0049 16.2 0.2 0.029 13.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 KPI90598.1 - 0.018 13.6 0.0 0.066 11.8 0.0 1.8 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) TrkA_N PF02254.18 KPI90598.1 - 0.048 13.9 0.2 0.11 12.8 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain Thi4 PF01946.17 KPI90598.1 - 0.056 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KPI90598.1 - 0.12 13.0 0.1 0.3 11.7 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SEP PF08059.13 KPI90600.1 - 2.6e-09 37.5 0.0 7.5e-09 36.0 0.0 1.8 1 0 0 1 1 1 1 SEP domain FPP PF05911.11 KPI90600.1 - 0.0011 17.2 7.3 0.0016 16.7 7.3 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil UBX PF00789.20 KPI90600.1 - 0.0019 18.4 0.0 0.0043 17.2 0.0 1.6 1 0 0 1 1 1 1 UBX domain tRNA-synt_1d PF00750.19 KPI90600.1 - 0.019 13.9 1.2 0.029 13.3 1.2 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (R) DUF2382 PF09557.10 KPI90600.1 - 0.096 12.9 0.6 0.26 11.6 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2382) Cep57_MT_bd PF06657.13 KPI90600.1 - 0.14 12.6 8.9 0.34 11.4 8.9 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Jnk-SapK_ap_N PF09744.9 KPI90600.1 - 0.17 12.1 8.2 0.36 11.1 8.2 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FapA PF03961.13 KPI90600.1 - 3.4 6.2 4.2 5.1 5.6 4.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TylF PF05711.11 KPI90601.1 - 6.2e-17 61.7 0.0 2e-13 50.2 0.0 2.3 2 0 0 2 2 2 2 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 KPI90601.1 - 4.1e-06 27.8 0.1 1.3e-05 26.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain CmcI PF04989.12 KPI90601.1 - 0.02 14.6 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase KH_1 PF00013.29 KPI90602.1 - 2.7e-07 30.3 0.0 5.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 KH domain SF1-HH PF16275.5 KPI90602.1 - 0.00016 22.0 0.0 0.00033 21.0 0.0 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain DUF520 PF04461.13 KPI90602.1 - 0.12 12.4 0.0 0.34 11.0 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF520) AIRS_C PF02769.22 KPI90603.1 - 5.9e-18 65.5 0.0 1.2e-17 64.5 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 KPI90603.1 - 5.8e-10 39.7 0.6 1.4e-09 38.5 0.1 1.9 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain BCS1_N PF08740.11 KPI90604.1 - 3.7e-30 105.3 4.8 5e-30 104.9 4.8 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 KPI90604.1 - 4.9e-10 39.9 0.1 0.00045 20.6 0.0 2.9 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KPI90604.1 - 0.0012 19.1 0.1 0.015 15.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KPI90604.1 - 0.0025 17.8 0.0 0.0089 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KPI90604.1 - 0.0033 17.8 0.3 0.073 13.4 0.2 2.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KPI90604.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KPI90604.1 - 0.013 14.6 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 KPI90604.1 - 0.039 13.7 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KPI90604.1 - 0.085 13.3 0.0 0.89 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 KPI90604.1 - 0.099 13.2 0.0 0.6 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 KPI90604.1 - 0.14 11.0 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TIP49 PF06068.13 KPI90604.1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 KPI90604.1 - 0.23 10.8 0.0 0.6 9.4 0.0 1.6 1 0 0 1 1 1 0 KaiC Pribosyltran_N PF13793.6 KPI90605.1 - 4.6e-39 132.9 0.1 1.3e-38 131.5 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KPI90605.1 - 6.6e-30 104.5 4.5 1.5e-29 103.3 1.8 2.2 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KPI90605.1 - 1.8e-15 56.8 0.8 3.4e-15 55.9 0.8 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KPI90605.1 - 0.00091 18.7 0.2 0.0019 17.7 0.2 1.6 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PreAtp-grasp PF18604.1 KPI90605.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Pre ATP-grasp domain Pyr_redox_2 PF07992.14 KPI90606.1 - 6.9e-55 186.3 0.0 8.7e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KPI90606.1 - 2.3e-12 47.3 0.0 6.8e-09 36.2 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KPI90606.1 - 8.3e-05 22.7 0.0 0.23 11.7 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KPI90606.1 - 0.0002 20.6 0.1 0.079 12.0 0.0 2.7 3 0 0 3 3 3 2 FAD binding domain GIDA PF01134.22 KPI90606.1 - 0.0049 16.0 0.1 1.7 7.6 0.0 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 KPI90606.1 - 0.0083 15.4 0.0 2.7 7.1 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KPI90606.1 - 0.04 13.5 0.5 31 4.0 0.0 3.2 2 1 1 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KPI90606.1 - 0.061 12.4 0.0 7 5.6 0.0 2.8 3 0 0 3 3 3 0 Lycopene cyclase protein Y_phosphatase PF00102.27 KPI90607.1 - 8.7e-66 221.8 0.1 1.1e-65 221.5 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KPI90607.1 - 6.9e-05 22.7 0.1 0.00014 21.6 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KPI90607.1 - 0.0002 21.4 0.0 0.00044 20.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Myotub-related PF06602.14 KPI90607.1 - 0.016 14.2 0.0 0.049 12.6 0.0 1.8 1 1 0 1 1 1 0 Myotubularin-like phosphatase domain PTPlike_phytase PF14566.6 KPI90607.1 - 0.018 15.1 0.0 0.048 13.8 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate DnaJ PF00226.31 KPI90609.1 - 1.1e-14 54.3 0.4 2.7e-14 53.0 0.4 1.7 1 1 0 1 1 1 1 DnaJ domain Amastin PF07344.11 KPI90610.1 - 1.5 8.6 16.2 0.14 12.0 9.0 2.5 1 1 1 2 2 2 0 Amastin surface glycoprotein OATP PF03137.20 KPI90614.1 - 0.0037 15.6 0.0 0.0037 15.6 0.0 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Phage_holin_3_6 PF07332.11 KPI90614.1 - 0.0056 16.7 0.2 0.0078 16.2 0.2 1.2 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Saf_2TM PF18303.1 KPI90614.1 - 0.02 14.5 0.0 0.022 14.4 0.0 1.1 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain TssO PF17561.2 KPI90614.1 - 0.026 14.6 0.0 0.034 14.3 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO LRR19-TM PF15176.6 KPI90614.1 - 0.052 13.5 0.0 0.067 13.2 0.0 1.1 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain FAM176 PF14851.6 KPI90614.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 FAM176 family YlaC PF10777.9 KPI90614.1 - 0.12 12.2 0.5 0.17 11.7 0.5 1.2 1 0 0 1 1 1 0 Inner membrane protein YlaC FeoB_associated PF12669.7 KPI90614.1 - 0.13 12.6 0.1 0.23 11.9 0.1 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein ATP-synt_S1 PF05827.12 KPI90614.1 - 0.17 11.7 0.1 0.3 10.9 0.1 1.4 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF3899 PF13038.6 KPI90615.1 - 0.089 13.3 0.0 0.25 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Neurensin PF14927.6 KPI90615.1 - 0.16 11.7 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Neurensin Tmemb_9 PF05434.11 KPI90615.1 - 0.23 11.3 0.7 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 TMEM9 Pox_T4_N PF04491.12 KPI90616.1 - 0.005 16.7 0.4 0.009 15.8 0.4 1.4 1 0 0 1 1 1 1 Poxvirus T4 protein, N terminus Img2 PF05046.14 KPI90617.1 - 1.1e-05 25.6 0.0 1.9e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) eIF-5_eIF-2B PF01873.17 KPI90618.1 - 5e-29 100.5 0.8 8.9e-29 99.7 0.8 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 CMAS PF02353.20 KPI90619.1 - 1.2e-76 257.6 0.2 2.1e-76 256.8 0.2 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 KPI90619.1 - 2.2e-17 63.6 0.0 4.8e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KPI90619.1 - 1.5e-14 54.4 0.0 3.5e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KPI90619.1 - 1e-12 48.2 0.0 1.9e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KPI90619.1 - 3.6e-11 43.7 0.0 1.9e-10 41.3 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 KPI90619.1 - 4.2e-07 29.7 0.0 2.4e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KPI90619.1 - 1.9e-06 27.7 0.0 5.7e-06 26.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 KPI90619.1 - 0.00015 21.8 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KPI90619.1 - 0.00024 20.8 0.0 0.00052 19.7 0.0 1.5 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.19 KPI90619.1 - 0.00027 21.1 0.0 0.00048 20.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase RrnaAD PF00398.20 KPI90619.1 - 0.00033 19.8 0.0 0.00053 19.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.19 KPI90619.1 - 0.00034 20.4 0.0 0.00055 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.11 KPI90619.1 - 0.00036 20.2 0.0 0.00065 19.4 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.14 KPI90619.1 - 0.0036 16.7 0.0 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.13 KPI90619.1 - 0.01 15.2 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 KPI90619.1 - 0.012 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TPMT PF05724.11 KPI90619.1 - 0.066 12.9 0.0 0.2 11.3 0.0 1.7 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Med25_NR-box PF11244.8 KPI90620.1 - 3.5 8.1 8.7 0.54 10.7 0.4 4.1 3 0 0 3 3 3 0 Mediator complex subunit 25 C-terminal NR box-containing Complex1_LYR PF05347.15 KPI90621.1 - 0.00063 19.8 0.7 0.0016 18.4 0.7 1.8 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Pkinase PF00069.25 KPI90622.1 - 2.4e-35 122.2 0.0 2.7e-13 49.9 0.0 4.1 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90622.1 - 1.7e-16 60.3 0.0 7.7e-07 28.7 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase EphA2_TM PF14575.6 KPI90622.1 - 0.12 13.3 0.1 1 10.3 0.0 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Pkinase PF00069.25 KPI90623.1 - 2.2e-44 151.8 0.0 6.5e-32 110.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90623.1 - 1.6e-22 80.0 0.0 1.3e-16 60.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kelch_5 PF13854.6 KPI90623.1 - 0.032 14.2 0.1 7.4 6.7 0.0 3.9 3 0 0 3 3 3 0 Kelch motif Pkinase_Tyr PF07714.17 KPI90624.1 - 2.6e-07 30.2 0.0 0.007 15.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KPI90624.1 - 2.3e-06 27.2 0.0 0.037 13.4 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Kelch_4 PF13418.6 KPI90624.1 - 0.00088 19.2 0.0 2.5 8.2 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 KPI90624.1 - 0.004 17.4 0.1 0.76 10.1 0.0 3.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Joubert PF15392.6 KPI90624.1 - 0.11 12.2 1.1 0.4 10.4 1.1 2.0 1 0 0 1 1 1 0 Joubert syndrome-associated Kelch_1 PF01344.25 KPI90624.1 - 0.63 9.7 6.1 0.78 9.4 0.0 3.6 3 1 0 3 3 3 0 Kelch motif Pribosyltran_N PF13793.6 KPI90625.1 - 7.7e-19 67.8 0.2 3e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KPI90625.1 - 2e-16 60.6 4.4 2.1e-16 60.5 0.3 2.7 3 0 0 3 3 3 1 Phosphoribosyl synthetase-associated domain SPX PF03105.19 KPI90625.1 - 7e-05 22.9 3.8 7e-05 22.9 3.8 3.4 2 1 1 3 3 3 2 SPX domain Pribosyltran PF00156.27 KPI90625.1 - 0.079 12.5 0.1 1 8.9 0.1 2.3 2 0 0 2 2 2 0 Phosphoribosyl transferase domain Rad60-SLD PF11976.8 KPI90629.1 - 7.3e-25 86.6 0.0 9.3e-25 86.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KPI90629.1 - 9.3e-12 44.5 0.0 1.2e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.8 KPI90629.1 - 0.13 12.5 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 TUG ubiquitin-like domain HTH_41 PF14502.6 KPI90629.1 - 0.15 11.7 0.1 0.44 10.3 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Peptidase_S24 PF00717.23 KPI90631.1 - 4.3e-08 33.0 0.1 7.5e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like Urb2 PF10441.9 KPI90632.1 - 3.3 7.6 12.2 0.078 12.9 0.2 3.4 3 0 0 3 3 3 0 Urb2/Npa2 family SOAR PF16533.5 KPI90633.1 - 0.41 10.7 7.7 1.2 9.1 7.0 2.2 1 1 0 1 1 1 0 STIM1 Orai1-activating region DUF4148 PF13663.6 KPI90634.1 - 0.29 11.3 4.5 1.9 8.8 4.5 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) BAF1_ABF1 PF04684.13 KPI90634.1 - 4.6 6.2 9.0 9.4 5.1 9.0 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor WD40 PF00400.32 KPI90635.1 - 2.6e-23 81.9 20.7 2.1e-06 28.3 0.0 9.6 9 1 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90635.1 - 6.2e-12 45.7 1.6 0.14 12.5 0.0 7.1 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KPI90635.1 - 5.6e-06 25.3 6.9 0.47 9.0 0.1 4.6 1 1 2 4 4 4 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 KPI90635.1 - 0.012 15.7 0.2 4.3 7.4 0.0 3.9 4 1 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region APG6 PF04111.12 KPI90636.1 - 2.2e-17 63.6 0.0 2.4e-13 50.4 0.0 3.5 2 1 0 2 2 2 2 Apg6 BARA domain FWWh PF14922.6 KPI90638.1 - 0.00098 19.1 0.1 0.0026 17.7 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function zf-Tim10_DDP PF02953.15 KPI90643.1 - 9.7e-15 54.0 2.3 1.4e-14 53.5 2.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2630 PF10944.8 KPI90643.1 - 0.044 14.2 0.8 0.21 12.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) DUF842 PF05811.13 KPI90643.1 - 0.063 13.0 3.1 0.12 12.1 3.1 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Isochorismatase PF00857.20 KPI90644.1 - 1.2e-09 38.6 0.0 2.2e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Isochorismatase family Isochorismatase PF00857.20 KPI90645.1 - 1.2e-08 35.3 0.9 1.2e-07 32.1 0.9 2.1 1 1 0 1 1 1 1 Isochorismatase family DUF4185 PF13810.6 KPI90645.1 - 0.0013 18.0 0.0 0.0017 17.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) zf-met2 PF12907.7 KPI90645.1 - 0.035 14.2 0.5 0.087 13.0 0.5 1.6 1 0 0 1 1 1 0 Zinc-binding Isochorismatase PF00857.20 KPI90646.1 - 4.9e-13 49.6 0.0 2.3e-12 47.5 0.0 1.9 1 1 0 1 1 1 1 Isochorismatase family Sod_Fe_C PF02777.18 KPI90647.1 - 4.9e-35 119.8 0.8 1e-34 118.7 0.0 1.8 3 0 0 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KPI90647.1 - 4.2e-18 65.6 1.3 1.7e-17 63.7 1.3 2.0 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Ribosomal_L2_C PF03947.18 KPI90648.1 - 1.4e-20 73.8 0.2 2.6e-20 72.9 0.2 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain YebO PF13974.6 KPI90650.1 - 4.2 7.5 7.9 2.9 8.0 2.6 2.8 2 0 0 2 2 2 0 YebO-like protein JHY PF15261.6 KPI90650.1 - 9.7 6.9 28.1 0.14 12.8 7.2 3.5 4 0 0 4 4 4 0 Jhy protein Ribosomal_L9_N PF01281.19 KPI90652.1 - 2.9e-06 26.7 0.0 6.4e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain ABC1 PF03109.16 KPI90653.1 - 1.7e-26 92.7 0.0 5.9e-26 91.0 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 KPI90653.1 - 0.00048 20.1 0.0 0.00095 19.1 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family ZZ PF00569.17 KPI90653.1 - 0.08 12.8 0.6 0.16 11.8 0.6 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type SUB1_ProdP9 PF18213.1 KPI90653.1 - 0.17 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 ThiF PF00899.21 KPI90654.1 - 9.9e-56 188.8 0.0 1e-54 185.5 0.0 2.3 1 1 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 KPI90654.1 - 9e-12 45.4 0.0 1.7e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 KPI90654.1 - 1.4e-05 25.2 0.2 0.01 15.8 0.0 2.5 3 0 0 3 3 3 2 Ubiquitin-activating enzyme active site Exo_endo_phos PF03372.23 KPI90656.1 - 1.5e-14 54.1 0.0 3e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KPI90656.1 - 0.11 12.4 0.0 0.4 10.5 0.0 1.9 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Hexapep PF00132.24 KPI90658.1 - 9.8e-14 50.5 8.5 3.1e-07 29.8 0.1 3.6 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KPI90658.1 - 0.00063 19.4 6.0 0.013 15.2 0.5 2.8 1 1 2 3 3 3 3 Hexapeptide repeat of succinyl-transferase AATase PF07247.12 KPI90658.1 - 0.091 11.3 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Alcohol acetyltransferase LIG3_BRCT PF16759.5 KPI90658.1 - 0.3 11.4 1.6 0.7 10.2 1.6 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain LRR_4 PF12799.7 KPI90659.1 - 2.5e-12 46.8 2.0 0.048 14.1 0.0 7.0 5 2 2 8 8 8 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KPI90659.1 - 0.00017 21.3 0.4 0.78 9.5 0.0 4.7 4 1 0 4 4 4 2 Leucine rich repeat MAGE_N PF12440.8 KPI90659.1 - 0.0073 17.0 1.4 0.12 13.0 1.3 2.4 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal PIG-H PF10181.9 KPI90661.1 - 3.5e-11 42.8 0.5 6.2e-11 42.0 0.5 1.4 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component ERCC4 PF02732.15 KPI90662.1 - 5.4e-14 52.7 0.0 1.2e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 ERCC4 domain EF-hand_6 PF13405.6 KPI90663.1 - 0.17 11.9 0.0 0.52 10.4 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain FYVE_2 PF02318.16 KPI90664.1 - 0.049 13.8 6.2 0.088 13.0 6.2 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger DUF5386 PF17360.2 KPI90666.1 - 0.0084 16.0 1.1 0.015 15.2 0.2 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5386) Cnn_1N PF07989.11 KPI90666.1 - 0.023 14.9 0.9 0.023 14.9 0.9 3.0 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 GAS PF13851.6 KPI90666.1 - 0.23 10.8 7.9 0.15 11.4 5.7 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4349 PF14257.6 KPI90666.1 - 0.62 9.5 16.4 1.5 8.3 16.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) CENP-F_leu_zip PF10473.9 KPI90666.1 - 1.8 8.5 15.1 0.8 9.7 3.1 2.7 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KPI90666.1 - 2.2 7.1 11.8 8.2 5.2 6.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 KPI90666.1 - 3.5 8.0 5.6 33 4.8 0.1 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CCDC-167 PF15188.6 KPI90666.1 - 5.4 7.4 10.8 4.2 7.8 0.1 2.9 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 CorA PF01544.18 KPI90666.1 - 5.6 6.2 8.9 70 2.6 8.1 2.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Fez1 PF06818.15 KPI90666.1 - 5.8 7.3 15.8 7.9 6.9 12.3 2.4 1 1 1 2 2 2 0 Fez1 DSPc PF00782.20 KPI90667.1 - 1.2e-27 96.3 0.0 2.3e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI90667.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KPI90667.1 - 0.062 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase2 PF03162.13 KPI90667.1 - 0.081 12.5 0.1 2 8.0 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KPI90667.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Adaptin_N PF01602.20 KPI90668.1 - 1.6e-75 254.7 0.0 2.1e-75 254.3 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KPI90668.1 - 6.4e-11 42.5 0.1 5.6e-06 26.5 0.0 2.8 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KPI90668.1 - 0.00026 21.3 0.2 0.92 9.9 0.0 3.8 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 KPI90668.1 - 0.0012 19.0 8.5 0.5 10.8 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.7 KPI90668.1 - 0.018 15.6 0.0 2.2 9.0 0.0 2.9 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region Terminase_6 PF03237.15 KPI90668.1 - 0.19 11.3 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 Terminase-like family HEAT_EZ PF13513.6 KPI90668.1 - 0.42 11.2 1.8 44 4.7 0.0 3.8 3 0 0 3 3 3 0 HEAT-like repeat DEAD PF00270.29 KPI90669.1 - 6.4e-39 133.5 0.0 1e-38 132.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KPI90669.1 - 8.5e-23 80.8 0.0 3.3e-22 78.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KPI90669.1 - 7.4e-05 22.8 0.0 0.00016 21.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 KPI90669.1 - 0.00095 18.5 0.0 0.0042 16.4 0.0 2.0 1 1 0 1 1 1 1 SecA DEAD-like domain AAA_22 PF13401.6 KPI90669.1 - 0.0018 18.6 0.3 0.024 14.9 0.3 2.6 1 1 0 1 1 1 1 AAA domain EccE PF11203.8 KPI90669.1 - 0.41 11.0 3.6 5.6 7.4 1.2 2.8 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE ASCH PF04266.14 KPI90670.1 - 1.6e-16 60.8 0.0 1.3e-15 57.9 0.0 2.3 2 0 0 2 2 2 1 ASCH domain zf-C2HC5 PF06221.13 KPI90670.1 - 0.00012 22.0 9.3 0.00025 21.0 9.3 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Siva PF05458.12 KPI90670.1 - 1.5 8.4 6.5 3 7.5 5.6 2.0 1 1 0 1 1 1 0 Cd27 binding protein (Siva) His_Phos_1 PF00300.22 KPI90671.1 - 1.4e-40 139.0 0.0 1.6e-40 138.9 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ECSIT PF06239.11 KPI90672.1 - 0.039 13.1 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway Synaptobrevin PF00957.21 KPI90674.1 - 1.1e-31 108.5 7.4 1.9e-31 107.7 7.4 1.4 1 0 0 1 1 1 1 Synaptobrevin EMP24_GP25L PF01105.24 KPI90674.1 - 0.0012 18.9 0.2 0.0017 18.3 0.2 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GET2 PF08690.10 KPI90674.1 - 0.003 17.3 0.2 0.004 16.9 0.2 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 LRRC37AB_C PF14914.6 KPI90674.1 - 0.012 15.5 1.2 0.016 15.2 0.5 1.6 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain FtsK_SpoIIIE PF01580.18 KPI90674.1 - 0.042 13.2 0.1 0.057 12.8 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family EVI2A PF05399.11 KPI90674.1 - 0.047 13.3 0.2 0.062 12.9 0.2 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF4844 PF16133.5 KPI90674.1 - 0.12 13.0 1.7 0.26 11.8 1.3 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4844) Longin PF13774.6 KPI90674.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Regulated-SNARE-like domain ODV-E18 PF10717.9 KPI90674.1 - 0.12 12.2 2.0 0.15 11.9 1.0 1.7 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF5345 PF17280.2 KPI90674.1 - 0.24 11.4 1.9 0.33 10.9 0.4 2.0 3 0 0 3 3 3 0 Family of unknown function (DUF5345) Orf78 PF06024.12 KPI90674.1 - 0.5 10.7 3.9 1 9.7 3.9 1.7 1 1 0 1 1 1 0 Orf78 (ac78) UPF0258 PF06789.12 KPI90674.1 - 1.6 8.9 4.4 3.1 7.9 4.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) TMEM154 PF15102.6 KPI90674.1 - 2.8 7.8 7.6 2.2 8.2 3.6 2.1 1 1 1 2 2 2 0 TMEM154 protein family Baculo_11_kDa PF06143.11 KPI90674.1 - 2.9 7.5 9.3 5.8 6.6 9.0 1.7 1 1 0 1 1 1 0 Baculovirus 11 kDa family Siva PF05458.12 KPI90675.1 - 5.7 6.6 25.0 11 5.6 25.0 1.5 1 0 0 1 1 1 0 Cd27 binding protein (Siva) SMC_N PF02463.19 KPI90676.1 - 2.8e-62 210.0 2.4 3.8e-62 209.6 2.4 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KPI90676.1 - 3.7e-27 94.9 0.0 1.8e-26 92.7 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 KPI90676.1 - 2.7e-16 60.7 7.3 2.7e-16 60.7 7.3 5.9 2 2 1 3 3 1 1 AAA domain AAA_21 PF13304.6 KPI90676.1 - 6.7e-16 59.0 0.3 3.8e-07 30.2 0.1 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KPI90676.1 - 6.9e-16 58.9 3.8 6.9e-16 58.9 3.8 4.0 2 2 2 5 5 4 2 AAA ATPase domain AAA_29 PF13555.6 KPI90676.1 - 0.0035 17.0 0.0 0.0082 15.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Shugoshin_N PF07558.11 KPI90676.1 - 0.012 15.4 8.7 1.6 8.6 0.6 4.3 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region ABC_tran PF00005.27 KPI90676.1 - 0.022 15.3 18.7 0.53 10.8 0.0 5.7 3 2 0 3 3 2 0 ABC transporter HTH_53 PF18606.1 KPI90676.1 - 0.032 13.9 0.1 0.13 11.9 0.1 2.1 1 0 0 1 1 1 0 Zap helix turn helix N-terminal domain DUF4250 PF14056.6 KPI90676.1 - 0.12 12.3 4.5 30 4.7 0.1 4.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4250) DUF2935 PF11155.8 KPI90676.1 - 3.5 8.0 10.4 16 5.9 0.5 4.6 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) Histone_H2A_C PF16211.5 KPI90677.1 - 5.9e-11 41.9 0.9 5.9e-11 41.9 0.9 1.6 2 0 0 2 2 2 1 C-terminus of histone H2A MutS_III PF05192.18 KPI90678.1 - 5e-19 69.3 0.1 9.3e-19 68.4 0.1 1.5 1 0 0 1 1 1 1 MutS domain III MutS_V PF00488.21 KPI90678.1 - 8.3e-16 58.6 0.2 1.7e-08 34.7 0.3 3.0 2 1 0 2 2 2 2 MutS domain V AAA_29 PF13555.6 KPI90678.1 - 0.076 12.8 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MORN PF02493.20 KPI90679.1 - 4.8e-51 167.7 87.8 1.2e-06 28.0 2.7 21.5 21 0 0 21 21 21 15 MORN repeat RebB PF11747.8 KPI90679.1 - 0.092 12.9 0.0 0.092 12.9 0.0 3.4 3 0 0 3 3 3 0 Killing trait DUF3048_C PF17479.2 KPI90679.1 - 2.6 8.5 10.0 12 6.3 0.1 4.9 4 1 1 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain Spt20 PF12090.8 KPI90679.1 - 3.1 7.3 9.1 6.7 6.3 9.1 1.5 1 0 0 1 1 1 0 Spt20 family 4HBT PF03061.22 KPI90680.1 - 1.6e-12 47.6 4.3 6.1e-09 36.1 0.7 3.2 2 1 0 2 2 2 2 Thioesterase superfamily Pepsin-I3 PF06394.13 KPI90680.1 - 0.088 13.0 1.1 17 5.7 0.2 2.5 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain 4HBT PF03061.22 KPI90681.1 - 4e-13 49.5 1.4 1.9e-05 24.9 0.1 2.5 2 0 0 2 2 2 2 Thioesterase superfamily MaoC_dehydratas PF01575.19 KPI90681.1 - 0.0068 16.0 0.5 3.7 7.2 0.1 2.5 2 0 0 2 2 2 2 MaoC like domain P4Ha_N PF08336.11 KPI90682.1 - 0.00083 19.4 0.1 0.0017 18.4 0.1 1.5 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region IF-2B PF01008.17 KPI90682.1 - 0.0088 15.3 0.4 0.011 15.0 0.4 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Med8 PF10232.9 KPI90682.1 - 0.011 15.3 2.2 0.38 10.3 0.3 2.2 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 DivIVA PF05103.13 KPI90682.1 - 0.027 14.6 1.3 0.027 14.6 1.3 2.0 2 0 0 2 2 2 0 DivIVA protein Fib_alpha PF08702.10 KPI90682.1 - 0.079 13.1 0.4 0.18 12.0 0.4 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Siah-Interact_N PF09032.11 KPI90682.1 - 0.092 13.1 0.4 0.092 13.1 0.4 2.0 2 1 0 2 2 2 0 Siah interacting protein, N terminal SHE3 PF17078.5 KPI90682.1 - 0.11 12.1 3.2 0.079 12.7 0.8 1.7 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 UPF0242 PF06785.11 KPI90682.1 - 0.28 11.3 4.8 0.1 12.7 1.8 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 KPI90682.1 - 0.44 9.4 6.9 0.071 12.0 2.8 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Rab5-bind PF09311.11 KPI90682.1 - 0.46 9.8 7.9 0.18 11.2 4.2 1.9 1 1 1 2 2 2 0 Rabaptin-like protein DUF2508 PF10704.9 KPI90682.1 - 1.3 9.2 4.5 0.44 10.7 1.5 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF2508) Spc24 PF08286.11 KPI90682.1 - 1.4 9.2 5.1 0.4 10.9 1.3 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 KPI90682.1 - 3.7 8.1 12.2 0.87 10.1 5.7 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region AATF-Che1 PF13339.6 KPI90682.1 - 7.1 7.3 9.1 29 5.3 9.1 2.1 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF4140 PF13600.6 KPI90682.1 - 8.3 6.9 11.6 0.56 10.7 4.4 2.3 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Thioredoxin PF00085.20 KPI90683.1 - 4.3e-07 29.9 0.0 0.0023 17.9 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Peptidase_S8 PF00082.22 KPI90684.1 - 6.3e-39 134.0 0.3 1.1e-38 133.2 0.3 1.3 1 0 0 1 1 1 1 Subtilase family CUB PF00431.20 KPI90684.1 - 4.5e-11 43.1 0.0 1e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 CUB domain ABC_tran PF00005.27 KPI90685.1 - 1.3e-27 97.0 0.1 2.1e-27 96.3 0.1 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KPI90685.1 - 7.8e-07 29.2 3.6 2.6e-05 24.2 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KPI90685.1 - 0.0012 18.3 0.1 0.022 14.2 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KPI90685.1 - 0.038 13.7 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KPI90685.1 - 0.044 13.5 0.2 5 6.8 0.1 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein SbcCD_C PF13558.6 KPI90685.1 - 0.047 13.9 0.3 0.93 9.8 0.3 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 KPI90685.1 - 0.06 13.7 0.1 0.13 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KPI90685.1 - 0.089 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 KPI90685.1 - 0.17 12.4 0.1 0.25 11.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain RINGv PF12906.7 KPI90686.1 - 4.7e-11 42.6 9.5 1.1e-10 41.4 9.5 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 KPI90686.1 - 0.052 13.9 7.8 0.11 12.9 7.8 1.6 1 0 0 1 1 1 0 Ring finger domain DUF4834 PF16118.5 KPI90686.1 - 0.31 12.0 5.7 13 6.8 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) dsrm PF00035.26 KPI90687.1 - 1.1e-06 29.2 0.0 0.11 13.2 0.0 3.9 4 0 0 4 4 4 2 Double-stranded RNA binding motif SYS1 PF09801.9 KPI90688.1 - 8e-17 61.7 2.2 4.4e-15 56.1 0.7 2.3 2 0 0 2 2 2 2 Integral membrane protein S linking to the trans Golgi network EMP70 PF02990.16 KPI90689.1 - 9.6e-141 470.0 11.2 1.2e-140 469.7 11.2 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 XPC-binding PF09280.11 KPI90692.1 - 2.6e-07 30.3 2.7 6.1e-07 29.1 2.5 1.8 1 1 0 1 1 1 1 XPC-binding domain UBA PF00627.31 KPI90692.1 - 0.0001 22.1 0.0 0.00027 20.8 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain ANAPC4_WD40 PF12894.7 KPI90693.1 - 0.032 14.5 0.0 0.5 10.7 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RabGAP-TBC PF00566.18 KPI90694.1 - 3.5e-40 137.9 0.0 4.9e-40 137.5 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SLAIN PF15301.6 KPI90697.1 - 0.18 11.0 0.0 0.18 11.0 0.0 2.6 3 0 0 3 3 3 0 SLAIN motif-containing family Nodulin-like PF06813.13 KPI90698.1 - 2.5e-08 33.7 15.2 2.5e-08 33.7 15.2 3.4 3 1 0 3 3 3 1 Nodulin-like SID-1_RNA_chan PF13965.6 KPI90698.1 - 0.00078 18.0 0.3 0.0024 16.4 0.0 2.0 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 Lin-8 PF03353.15 KPI90698.1 - 0.57 9.7 5.5 0.88 9.1 5.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Asn_synthase PF00733.21 KPI90699.1 - 3.4e-15 56.6 1.4 0.0013 18.5 0.0 3.8 3 1 1 4 4 4 3 Asparagine synthase Ank_2 PF12796.7 KPI90701.1 - 1.1e-06 29.1 0.1 2.5e-06 28.0 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI90701.1 - 0.00015 21.9 0.1 0.00049 20.4 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KPI90701.1 - 0.00042 20.8 0.1 0.0011 19.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI90701.1 - 0.00044 20.5 0.1 0.45 11.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KPI90701.1 - 0.061 13.8 1.0 5.4 7.6 0.1 3.0 2 0 0 2 2 2 0 Ankyrin repeat Acetyltransf_13 PF13880.6 KPI90701.1 - 0.076 13.0 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_10 PF13673.7 KPI90701.1 - 0.088 12.7 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KPI90701.1 - 0.18 12.2 0.0 0.38 11.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain P3A PF08727.11 KPI90703.1 - 0.052 12.9 0.0 0.15 11.5 0.0 1.7 1 0 0 1 1 1 0 Poliovirus 3A protein like PI3_PI4_kinase PF00454.27 KPI90704.1 - 2.5e-36 125.8 0.4 6.2e-24 85.2 0.1 2.6 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KPI90704.1 - 3.2e-14 52.8 0.2 6.4e-14 51.8 0.2 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 KPI90704.1 - 0.019 14.3 0.0 0.049 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) HTH_24 PF13412.6 KPI90704.1 - 0.16 11.5 0.0 9 5.9 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Clat_adaptor_s PF01217.20 KPI90705.1 - 2.8e-48 163.5 2.1 3.3e-48 163.2 2.1 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-LYAR PF08790.11 KPI90708.1 - 4.3e-12 45.7 2.2 4.3e-12 45.7 2.2 2.3 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zinc_ribbon_12 PF11331.8 KPI90708.1 - 0.14 12.0 1.7 0.26 11.1 1.7 1.4 1 0 0 1 1 1 0 Probable zinc-ribbon domain RRM_1 PF00076.22 KPI90709.1 - 2.4e-20 72.1 0.0 2.1e-12 46.7 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI90709.1 - 0.0063 16.6 0.0 2.1 8.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif DUF3562 PF12085.8 KPI90710.1 - 0.039 13.6 0.2 0.13 11.9 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3562) RRM_1 PF00076.22 KPI90711.1 - 1.9e-26 91.6 0.0 1.2e-13 50.7 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KPI90711.1 - 2.6e-05 24.2 0.0 0.028 14.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 KPI90711.1 - 0.18 12.0 0.2 34 4.6 0.0 3.7 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 KPI90712.1 - 1.2e-25 89.1 0.0 2.1e-14 53.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KPI90712.1 - 8.1e-05 22.2 0.0 0.051 13.2 0.0 2.6 1 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KPI90712.1 - 9.1e-05 22.6 0.0 0.13 12.5 0.0 2.4 2 0 0 2 2 2 2 RRM-like domain Nup35_RRM_2 PF14605.6 KPI90712.1 - 0.11 12.6 0.0 4.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif FliP PF00813.20 KPI90713.1 - 2.3 8.0 7.7 7.2 6.4 7.7 1.8 1 0 0 1 1 1 0 FliP family V_ATPase_I PF01496.19 KPI90713.1 - 3.3 5.5 9.5 6.4 4.6 9.5 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5336 PF17270.2 KPI90714.1 - 0.11 12.1 1.9 4.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5336) SCP1201-deam PF14428.6 KPI90714.1 - 0.56 10.1 4.3 0.32 10.9 2.3 1.6 2 0 0 2 2 2 0 SCP1.201-like deaminase Pneumo_att_G PF05539.11 KPI90714.1 - 2 7.9 9.5 2.2 7.8 9.5 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Ndc1_Nup PF09531.10 KPI90714.1 - 2.7 6.6 7.7 3.2 6.3 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CBP_BcsG PF11658.8 KPI90714.1 - 5.9 5.2 8.2 18 3.5 8.2 1.9 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsG TTL PF03133.15 KPI90715.1 - 1e-77 261.2 0.0 1.4e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KPI90715.1 - 0.0034 16.7 0.0 0.035 13.3 0.0 2.3 2 1 0 2 2 2 1 YheC/D like ATP-grasp DUF4303 PF14136.6 KPI90715.1 - 0.0085 15.8 0.1 0.019 14.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4303) Pkinase PF00069.25 KPI90716.1 - 7.9e-57 192.6 0.0 1.2e-56 192.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90716.1 - 4.4e-36 124.5 0.0 6.6e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KPI90716.1 - 5.2e-11 43.0 0.0 2.8e-10 40.7 0.0 2.1 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.6 KPI90716.1 - 1.1e-07 31.5 0.0 1.9e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 KPI90716.1 - 0.023 15.1 0.3 0.1 13.0 0.3 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Mcp5_PH PF12814.7 KPI90716.1 - 0.077 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology MCM PF00493.23 KPI90717.1 - 3.2e-59 199.8 0.0 4.9e-59 199.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 KPI90717.1 - 7e-15 55.2 0.0 2.1e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 KPI90717.1 - 1.9e-11 43.9 1.2 3.9e-11 42.9 1.2 1.5 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 KPI90717.1 - 4.2e-05 23.0 0.1 0.014 14.8 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KPI90717.1 - 6.6e-05 22.9 0.0 0.00016 21.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KPI90717.1 - 0.007 16.2 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad51 PF08423.11 KPI90719.1 - 2.3e-123 410.4 0.0 2.9e-123 410.1 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 KPI90719.1 - 2.4e-13 50.2 0.2 3.3e-13 49.7 0.2 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 KPI90719.1 - 3.1e-07 30.9 0.5 1.1e-06 29.2 0.5 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_25 PF13481.6 KPI90719.1 - 4.2e-07 29.7 0.0 8.7e-07 28.7 0.0 1.5 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 KPI90719.1 - 1.8e-06 27.5 0.0 3.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 KaiC DnaB_C PF03796.15 KPI90719.1 - 0.085 12.2 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_24 PF13479.6 KPI90719.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TPR_1 PF00515.28 KPI90720.1 - 3.9e-13 48.6 14.5 7.8e-05 22.3 0.4 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90720.1 - 6.2e-13 47.8 15.7 0.0007 19.5 1.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI90720.1 - 1.1e-09 37.8 8.3 4e-07 29.6 2.5 3.3 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 KPI90720.1 - 2e-07 30.7 13.4 0.0046 17.1 1.5 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 KPI90720.1 - 2.2e-06 27.4 8.2 0.045 13.6 0.5 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KPI90720.1 - 4e-06 27.0 7.0 0.0006 20.0 3.3 3.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KPI90720.1 - 4.4e-05 24.0 4.3 0.61 11.0 0.6 4.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KPI90720.1 - 9.7e-05 22.9 2.5 9.7e-05 22.9 2.5 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KPI90720.1 - 0.00026 20.8 2.0 2.5 8.3 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KPI90720.1 - 0.0003 20.9 2.3 0.0003 20.9 2.3 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI90720.1 - 0.0015 18.8 3.4 0.0015 18.8 3.4 3.3 4 0 0 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KPI90720.1 - 0.0017 18.8 5.9 0.064 13.8 0.2 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat DUF4810 PF16068.5 KPI90720.1 - 0.12 12.9 0.7 0.34 11.5 0.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4810) TPR_4 PF07721.14 KPI90720.1 - 0.23 12.2 0.1 0.23 12.2 0.1 3.1 4 0 0 4 4 2 0 Tetratricopeptide repeat PDR_assoc PF08370.11 KPI90720.1 - 0.28 11.0 2.6 0.35 10.7 0.1 2.2 2 0 0 2 2 2 0 Plant PDR ABC transporter associated TPR_6 PF13174.6 KPI90720.1 - 0.54 11.0 7.2 59 4.6 0.2 4.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 KPI90720.1 - 0.9 9.6 13.6 3.6 7.7 1.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Spc7 PF08317.11 KPI90721.1 - 9.2e-07 28.0 18.4 9.2e-07 28.0 18.4 8.1 1 1 9 10 10 10 2 Spc7 kinetochore protein FAM184 PF15665.5 KPI90721.1 - 0.00015 21.7 6.7 0.00015 21.7 6.7 8.0 1 1 7 8 8 8 4 Family with sequence similarity 184, A and B Proteasome PF00227.26 KPI90723.1 - 6.1e-38 130.2 0.1 9e-38 129.7 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KPI90723.1 - 1.5e-11 43.8 0.2 1.5e-11 43.8 0.2 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature PhetRS_B1 PF18262.1 KPI90725.1 - 0.035 14.3 0.0 0.099 12.9 0.0 1.7 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain UBA PF00627.31 KPI90725.1 - 0.041 13.8 0.6 0.085 12.8 0.1 1.8 2 0 0 2 2 2 0 UBA/TS-N domain His_Phos_1 PF00300.22 KPI90726.1 - 8.1e-11 42.0 0.1 0.002 17.9 0.0 3.2 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) BRCT_2 PF16589.5 KPI90727.1 - 1.1e-06 28.9 0.0 8.7e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-RanBP PF00641.18 KPI90727.1 - 0.024 14.0 0.2 0.063 12.6 0.2 1.8 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others BRCT PF00533.26 KPI90727.1 - 0.039 14.3 0.0 11 6.5 0.0 2.7 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain BRCT_3 PF18428.1 KPI90727.1 - 0.14 12.2 0.0 21 5.3 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain A_deaminase PF00962.22 KPI90728.1 - 1.6e-122 409.0 0.0 4.9e-90 302.2 0.0 2.3 2 0 0 2 2 2 2 Adenosine/AMP deaminase SOAR PF16533.5 KPI90728.1 - 0.26 11.3 1.9 0.86 9.6 1.9 1.8 1 0 0 1 1 1 0 STIM1 Orai1-activating region Spc7 PF08317.11 KPI90728.1 - 1.2 7.9 5.2 0.65 8.8 3.0 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein SCAMP PF04144.13 KPI90729.1 - 1.6e-34 119.7 19.3 1.9e-34 119.4 19.3 1.0 1 0 0 1 1 1 1 SCAMP family CPP1-like PF11833.8 KPI90729.1 - 0.045 13.4 0.5 0.31 10.7 0.0 2.1 2 1 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF1129 PF06570.11 KPI90729.1 - 0.46 9.9 6.2 0.66 9.4 6.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Pro_isomerase PF00160.21 KPI90731.1 - 2.3e-46 158.0 0.0 4.2e-46 157.1 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 KPI90731.1 - 2.5e-11 42.8 3.3 0.0033 17.4 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KPI90731.1 - 3.1e-08 33.1 3.8 0.12 12.3 0.4 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KPI90731.1 - 9.1e-06 25.3 1.3 0.43 10.3 0.1 3.5 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.6 KPI90731.1 - 4.2e-05 23.6 0.1 0.00012 22.1 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 KPI90731.1 - 0.00016 22.1 0.1 2 9.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KPI90731.1 - 0.00026 21.6 3.5 0.0011 19.5 1.3 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KPI90731.1 - 0.0042 17.4 1.6 0.13 12.7 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 KPI90731.1 - 0.0073 16.3 2.9 0.019 15.0 0.5 2.3 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain DUF1586 PF07625.11 KPI90731.1 - 0.025 14.6 0.3 0.064 13.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1586) TPR_8 PF13181.6 KPI90731.1 - 0.034 14.4 0.5 35 4.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KPI90731.1 - 0.048 14.5 0.4 8.4 7.5 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KPI90731.1 - 0.064 13.5 2.0 2.2 8.5 1.5 2.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Myco_19_kDa PF05481.12 KPI90731.1 - 0.065 13.5 0.2 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen TPR_19 PF14559.6 KPI90731.1 - 0.075 13.5 1.9 3.5 8.2 0.3 2.7 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KPI90731.1 - 0.087 13.1 1.6 3.1 8.2 0.5 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat PDZ PF00595.24 KPI90731.1 - 0.17 12.2 0.0 0.45 10.9 0.0 1.7 1 0 0 1 1 1 0 PDZ domain DUF1761 PF08570.10 KPI90732.1 - 0.1 12.9 6.4 0.18 12.1 6.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1761) PhnG PF06754.12 KPI90733.1 - 0.021 14.8 2.1 0.021 14.8 2.1 2.8 1 1 1 2 2 2 0 Phosphonate metabolism protein PhnG GCV_H PF01597.19 KPI90734.1 - 6e-39 132.7 1.8 7.1e-39 132.5 1.8 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 KPI90734.1 - 8.9e-07 28.7 1.5 1.2e-06 28.2 0.7 1.6 2 0 0 2 2 2 1 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 KPI90734.1 - 4.7e-05 23.1 0.1 6.4e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 RnfC_N PF13375.6 KPI90734.1 - 0.00019 21.3 0.1 0.00026 20.9 0.1 1.4 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Peptidase_M23 PF01551.22 KPI90734.1 - 0.071 13.3 0.8 6.4 7.1 0.1 2.3 1 1 1 2 2 2 0 Peptidase family M23 DUF4179 PF13786.6 KPI90734.1 - 0.079 13.4 0.1 0.16 12.4 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) HSP70 PF00012.20 KPI90735.1 - 5.7e-57 193.2 0.0 2.5e-56 191.1 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KPI90735.1 - 0.0026 16.6 0.0 0.022 13.6 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein Kinesin PF00225.23 KPI90736.1 - 3.9e-56 190.4 0.2 7.6e-56 189.4 0.2 1.5 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KPI90736.1 - 1.5e-08 34.8 0.0 3.1e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KPI90736.1 - 0.0025 18.2 0.1 0.0066 16.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 KPI90736.1 - 0.055 13.6 0.0 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain Myosin_head PF00063.21 KPI90736.1 - 0.12 10.6 0.0 0.22 9.7 0.0 1.3 1 0 0 1 1 1 0 Myosin head (motor domain) AAA_22 PF13401.6 KPI90736.1 - 0.15 12.3 0.0 0.43 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain ParcG PF10274.9 KPI90737.1 - 1.7e-74 249.9 0.0 2.1e-74 249.6 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein CENP-F_leu_zip PF10473.9 KPI90738.1 - 0.00064 19.8 3.2 0.00064 19.8 3.2 2.5 3 0 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAP1_N PF04849.13 KPI90738.1 - 0.018 14.3 1.2 0.018 14.3 1.2 2.4 2 1 0 2 2 2 0 HAP1 N-terminal conserved region APC_N_CC PF16689.5 KPI90738.1 - 0.02 14.9 0.2 0.02 14.9 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Med11 PF10280.9 KPI90738.1 - 0.12 12.8 9.5 2.6 8.5 1.4 2.5 1 1 1 2 2 2 0 Mediator complex protein XhlA PF10779.9 KPI90738.1 - 0.13 12.5 0.2 0.41 10.9 0.2 1.9 1 0 0 1 1 1 0 Haemolysin XhlA LMBR1 PF04791.16 KPI90738.1 - 1.1 8.1 3.9 1.6 7.6 3.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Ribosomal_L29 PF00831.23 KPI90738.1 - 1.2 9.1 5.1 2.3 8.3 0.1 3.2 3 1 0 3 3 3 0 Ribosomal L29 protein COG2 PF06148.11 KPI90738.1 - 1.3 9.1 12.6 1.3 9.1 2.2 3.1 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.12 KPI90738.1 - 1.6 8.7 7.8 1.7 8.7 1.3 2.6 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-ZPR1 PF03367.13 KPI90738.1 - 2.5 7.9 4.3 10 5.9 0.4 2.6 3 0 0 3 3 3 0 ZPR1 zinc-finger domain UPF0449 PF15136.6 KPI90738.1 - 5.1 7.6 8.0 1.5 9.4 0.5 3.1 3 1 0 3 3 3 0 Uncharacterised protein family UPF0449 YabA PF06156.13 KPI90738.1 - 5.8 7.6 16.1 0.25 12.0 3.2 2.8 3 0 0 3 3 3 0 Initiation control protein YabA WD40 PF00400.32 KPI90739.1 - 4.8e-25 87.3 5.5 2.1e-05 25.2 0.1 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat Katanin_con80 PF13925.6 KPI90739.1 - 4.3e-20 72.4 0.2 6.1e-20 71.9 0.2 1.2 1 0 0 1 1 1 1 con80 domain of Katanin ANAPC4_WD40 PF12894.7 KPI90739.1 - 2.1e-12 47.2 0.0 7.7e-06 26.1 0.0 3.5 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KPI90739.1 - 0.0031 16.9 0.0 0.81 9.0 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 KPI90739.1 - 0.018 14.0 0.0 0.2 10.6 0.0 2.4 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KPI90739.1 - 0.023 14.6 0.0 1.2 9.0 0.0 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A zf-SNAP50_C PF12251.8 KPI90740.1 - 9.8e-36 123.3 0.1 1.5e-35 122.7 0.1 1.2 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Histidinol_dh PF00815.20 KPI90740.1 - 0.14 11.1 0.1 0.2 10.6 0.1 1.1 1 0 0 1 1 1 0 Histidinol dehydrogenase DSPc PF00782.20 KPI90741.1 - 7.7e-21 74.3 0.0 1.3e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KPI90741.1 - 0.0094 15.5 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Cgr1 PF03879.14 KPI90742.1 - 1e-06 29.0 25.4 1.3e-06 28.7 25.4 1.2 1 0 0 1 1 1 1 Cgr1 family LPP20 PF02169.16 KPI90742.1 - 0.017 15.4 1.6 0.02 15.2 1.6 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein FAM178 PF14816.6 KPI90742.1 - 0.047 12.6 6.2 0.058 12.4 6.2 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 DUF572 PF04502.13 KPI90742.1 - 0.18 11.4 15.1 0.19 11.3 15.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) AAA_11 PF13086.6 KPI90742.1 - 0.27 11.0 12.2 0.29 10.9 12.2 1.0 1 0 0 1 1 1 0 AAA domain DnaJ PF00226.31 KPI90743.1 - 1.5e-14 53.9 0.1 2.9e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain DUF898 PF05987.13 KPI90743.1 - 0.089 11.8 0.0 3.5 6.6 0.0 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Pkinase PF00069.25 KPI90744.1 - 2.4e-15 56.6 0.0 1.2e-10 41.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90744.1 - 0.00014 21.2 0.0 0.00091 18.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PAM2 PF07145.15 KPI90744.1 - 0.12 12.1 0.3 0.27 11.0 0.3 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region BRE1 PF08647.11 KPI90746.1 - 0.018 15.1 4.4 0.018 15.1 4.4 5.3 5 1 1 6 6 6 0 BRE1 E3 ubiquitin ligase FeoC PF09012.10 KPI90746.1 - 0.023 14.7 0.3 0.78 9.9 0.0 3.1 3 0 0 3 3 3 0 FeoC like transcriptional regulator Fungal_TACC PF12709.7 KPI90746.1 - 1.1 9.7 0.0 1.1 9.7 0.0 4.3 3 2 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Takusan PF04822.13 KPI90746.1 - 3.6 7.5 13.7 0.45 10.4 1.7 3.4 3 0 0 3 3 3 0 Takusan PS_Dcarbxylase PF02666.15 KPI90747.1 - 1.9e-36 125.5 0.0 2.3e-36 125.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase 60KD_IMP PF02096.20 KPI90748.1 - 6.6e-07 29.4 0.0 9.8e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein DUF1029 PF06269.12 KPI90748.1 - 0.17 12.0 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1029) Robl_LC7 PF03259.17 KPI90749.1 - 0.00032 20.4 1.8 0.0026 17.5 1.8 2.0 1 1 0 1 1 1 1 Roadblock/LC7 domain UxaE PF16257.5 KPI90749.1 - 0.022 13.4 0.0 0.025 13.3 0.0 1.0 1 0 0 1 1 1 0 tagaturonate epimerase zf-HC5HC2H PF13771.6 KPI90750.1 - 8.2e-14 51.6 7.0 8.2e-14 51.6 7.0 1.7 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KPI90750.1 - 1.9e-10 40.9 8.3 4.3e-10 39.7 8.3 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-ANAPC11 PF12861.7 KPI90750.1 - 0.094 12.8 6.2 0.18 11.8 6.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger SET PF00856.28 KPI90751.1 - 4.5e-36 124.8 0.3 1.4e-08 35.3 0.0 7.9 7 2 0 8 8 8 5 SET domain SAF PF08666.12 KPI90751.1 - 0.00045 20.8 0.1 39 5.0 0.0 7.2 9 0 0 9 9 9 1 SAF domain FPL PF09758.9 KPI90752.1 - 2.2e-51 173.8 1.6 3.6e-51 173.0 1.6 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF962 PF06127.11 KPI90754.1 - 7.1e-20 70.9 5.9 1.1e-19 70.3 5.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) zf-ANAPC11 PF12861.7 KPI90756.1 - 4.1e-29 100.5 10.3 4.5e-29 100.4 10.3 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KPI90756.1 - 7.5e-19 67.8 12.6 1e-18 67.4 12.6 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KPI90756.1 - 7.1e-07 29.5 19.5 2.9e-05 24.3 19.5 2.6 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KPI90756.1 - 2e-06 27.5 18.3 7.5e-06 25.7 7.8 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KPI90756.1 - 4.2e-06 26.7 10.1 9e-06 25.6 10.1 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KPI90756.1 - 1.4e-05 24.9 13.8 1.4e-05 24.8 12.8 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KPI90756.1 - 8.9e-05 22.4 18.2 0.00039 20.3 17.1 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.6 KPI90756.1 - 0.0019 18.0 3.4 0.0019 18.0 3.4 2.9 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 KPI90756.1 - 0.0019 18.0 18.0 0.65 9.9 12.2 2.7 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KPI90756.1 - 0.0034 17.0 5.4 0.0034 17.0 5.4 1.7 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 KPI90756.1 - 0.014 15.5 4.9 0.014 15.5 4.9 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KPI90756.1 - 0.016 14.9 16.1 0.47 10.2 16.1 2.5 1 1 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 KPI90756.1 - 0.13 12.1 9.6 0.21 11.4 9.6 1.4 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-HIT PF04438.16 KPI90756.1 - 0.19 11.6 9.9 0.6 10.0 5.4 2.4 2 1 0 2 2 2 0 HIT zinc finger PHD PF00628.29 KPI90756.1 - 2.6 8.0 14.9 37 4.3 14.9 2.4 1 1 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 KPI90756.1 - 8.2 6.8 17.7 58 4.1 17.7 2.3 1 1 0 1 1 1 0 RING-like domain DUF2569 PF10754.9 KPI90757.1 - 0.11 12.9 2.1 0.22 12.0 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) ARL2_Bind_BART PF11527.8 KPI90758.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.4 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART CS PF04969.16 KPI90759.1 - 2.2e-08 35.0 0.1 3e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 CS domain Forkhead_N PF08430.12 KPI90759.1 - 0.0062 17.1 10.1 0.0092 16.6 10.1 1.2 1 0 0 1 1 1 1 Forkhead N-terminal region TraT PF05818.12 KPI90759.1 - 1.2 8.8 4.3 2 8.1 4.3 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein LSM PF01423.22 KPI90760.1 - 3.8e-19 68.1 0.0 4.3e-19 68.0 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KPI90760.1 - 0.00087 19.4 0.0 0.00094 19.3 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain zf-CCCH_3 PF15663.5 KPI90761.1 - 0.0025 18.0 0.1 0.028 14.6 0.1 2.4 2 1 0 2 2 2 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 KPI90761.1 - 0.051 13.4 6.9 0.25 11.2 6.9 2.1 1 1 0 1 1 1 0 CCCH-type zinc finger zf-CCCH PF00642.24 KPI90761.1 - 0.38 10.7 6.6 0.095 12.6 3.2 1.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI90761.1 - 0.92 9.7 8.2 0.91 9.7 1.8 2.6 2 0 0 2 2 2 0 Zinc finger domain zf-C3H1 PF10650.9 KPI90761.1 - 2 8.2 4.0 0.76 9.6 0.4 2.1 2 0 0 2 2 2 0 Putative zinc-finger domain zf-CCCH_2 PF14608.6 KPI90761.1 - 3.1 8.4 12.0 0.13 12.8 5.8 1.9 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Mito_carr PF00153.27 KPI90763.1 - 2.8e-30 104.1 8.8 4.1e-18 65.1 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein ArsB PF02040.15 KPI90763.1 - 0.14 11.5 0.3 0.19 11.0 0.3 1.1 1 0 0 1 1 1 0 Arsenical pump membrane protein DUF1746 PF08508.10 KPI90763.1 - 0.14 12.5 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) AA_permease_2 PF13520.6 KPI90764.1 - 1.3e-40 139.6 43.7 1.6e-40 139.2 43.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KPI90764.1 - 5e-11 41.9 37.1 9.2e-11 41.0 37.0 1.5 1 1 0 1 1 1 1 Amino acid permease Snf7 PF03357.21 KPI90765.1 - 7.9e-13 48.4 19.1 1e-12 48.0 18.6 1.4 1 1 1 2 2 2 1 Snf7 DUF445 PF04286.12 KPI90765.1 - 0.045 13.6 2.4 0.054 13.3 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) UCH PF00443.29 KPI90765.1 - 0.094 12.2 1.5 0.14 11.6 1.5 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase TPR_12 PF13424.6 KPI90766.1 - 7.9e-10 38.9 2.5 0.00083 19.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat PAP_fibrillin PF04755.12 KPI90767.1 - 0.097 12.6 1.4 0.13 12.2 1.4 1.1 1 0 0 1 1 1 0 PAP_fibrillin T7SS_ESX_EspC PF10824.8 KPI90770.1 - 0.52 10.8 6.5 9.5 6.8 0.5 4.5 4 0 0 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm DNA_pol_A_exo1 PF01612.20 KPI90771.1 - 1.3e-14 54.3 0.0 9.2e-14 51.5 0.0 2.0 1 1 0 1 1 1 1 3'-5' exonuclease CBFD_NFYB_HMF PF00808.23 KPI90772.1 - 0.00013 22.2 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Cation_efflux PF01545.21 KPI90773.1 - 0.002 17.9 13.3 0.0053 16.5 13.3 1.6 1 1 0 1 1 1 1 Cation efflux family Cpn60_TCP1 PF00118.24 KPI90775.1 - 5.2e-81 272.7 5.2 1.1e-80 271.6 5.2 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ras PF00071.22 KPI90776.1 - 8.8e-36 123.0 0.0 1e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KPI90776.1 - 5.2e-33 113.8 0.0 7.1e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KPI90776.1 - 3.2e-11 43.0 0.0 3.8e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KPI90776.1 - 3.9e-07 29.7 0.0 6.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KPI90776.1 - 1.5e-06 27.8 0.0 1.8e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KPI90776.1 - 7.7e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KPI90776.1 - 5e-05 22.9 0.0 0.0018 17.9 0.0 2.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KPI90776.1 - 0.0003 20.7 0.0 0.00053 19.9 0.0 1.4 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein TniB PF05621.11 KPI90776.1 - 0.00047 19.6 0.0 0.0028 17.1 0.0 2.1 3 0 0 3 3 3 1 Bacterial TniB protein RsgA_GTPase PF03193.16 KPI90776.1 - 0.0008 19.3 0.0 1 9.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 KPI90776.1 - 0.004 17.2 0.0 0.0068 16.4 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain AAA_16 PF13191.6 KPI90776.1 - 0.06 13.7 0.0 0.12 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Sod_Fe_C PF02777.18 KPI90777.1 - 2.4e-40 136.8 0.5 4e-40 136.1 0.5 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KPI90777.1 - 5.7e-22 78.0 0.1 4.3e-21 75.2 0.0 2.0 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Pkinase PF00069.25 KPI90778.1 - 2.3e-47 161.6 0.0 2e-39 135.6 0.0 3.0 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90778.1 - 4.7e-30 104.7 0.0 9.4e-30 103.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KPI90778.1 - 8.1e-07 29.5 0.0 1.5e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 KPI90778.1 - 0.00048 19.5 0.0 0.00085 18.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KPI90778.1 - 0.023 14.6 0.2 0.052 13.5 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF4687 PF15747.5 KPI90778.1 - 0.077 13.5 1.0 0.59 10.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4687) PH_9 PF15410.6 KPI90778.1 - 0.085 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain DUF515 PF04415.12 KPI90779.1 - 0.85 7.9 2.2 1 7.7 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Nop14 PF04147.12 KPI90780.1 - 0.079 11.2 17.2 0.092 11.0 17.2 1.0 1 0 0 1 1 1 0 Nop14-like family CNDH2_C PF16858.5 KPI90780.1 - 0.29 11.0 6.7 0.39 10.6 6.7 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Glyco_trans_1_2 PF13524.6 KPI90784.1 - 0.019 15.4 2.5 1.1 9.7 0.0 3.1 3 0 0 3 3 3 0 Glycosyl transferases group 1 PUF PF00806.19 KPI90785.1 - 6.6e-22 75.9 0.0 0.0053 16.4 0.0 9.6 11 0 0 11 11 11 6 Pumilio-family RNA binding repeat Cytomega_UL84 PF06284.11 KPI90785.1 - 0.0052 15.3 0.1 0.011 14.3 0.1 1.6 1 0 0 1 1 1 1 Cytomegalovirus UL84 protein DUF787 PF05619.11 KPI90785.1 - 0.015 14.5 0.4 0.21 10.7 0.0 2.1 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF787) Connexin PF00029.19 KPI90785.1 - 0.019 14.7 2.4 0.28 10.9 1.3 2.4 2 0 0 2 2 2 0 Connexin DUF3223 PF11523.8 KPI90785.1 - 0.83 10.5 3.3 68 4.4 0.2 4.4 3 2 0 3 3 3 0 Protein of unknown function (DUF3223) Peroxin-13_N PF04088.13 KPI90785.1 - 1.9 8.8 5.9 14 6.0 0.1 3.0 3 0 0 3 3 3 0 Peroxin 13, N-terminal region WW PF00397.26 KPI90786.1 - 1.7e-12 47.2 1.2 3.1e-12 46.4 1.2 1.5 1 0 0 1 1 1 1 WW domain zf-CCCH PF00642.24 KPI90786.1 - 7.5e-06 25.7 0.7 1.2e-05 25.1 0.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KPI90786.1 - 0.00013 21.9 1.3 0.00027 20.9 1.3 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KPI90786.1 - 0.0024 17.6 0.7 0.0038 17.0 0.7 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 KPI90786.1 - 0.012 16.3 0.3 0.015 16.0 0.3 1.2 1 0 0 1 1 1 0 Torus domain zf-CCCH_2 PF14608.6 KPI90786.1 - 0.056 13.9 0.5 0.12 12.8 0.5 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF3756 PF12581.8 KPI90786.1 - 0.082 12.8 0.6 0.36 10.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3756) Coatomer_E PF04733.14 KPI90787.1 - 9.9e-33 113.8 6.1 4.1e-32 111.8 6.1 1.7 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_14 PF13428.6 KPI90787.1 - 9.3e-05 22.9 13.9 1.3 10.1 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KPI90787.1 - 0.0007 20.1 8.1 0.37 11.3 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KPI90787.1 - 0.0014 18.7 2.7 0.85 10.0 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KPI90787.1 - 0.0034 17.1 1.7 1.8 8.5 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KPI90787.1 - 0.0078 16.3 5.6 1.6 9.0 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 KPI90787.1 - 0.031 14.9 8.9 0.73 10.6 0.6 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat OstA_2 PF13100.6 KPI90787.1 - 0.033 13.8 0.2 2.8 7.5 0.0 2.4 2 0 0 2 2 2 0 OstA-like protein CD225 PF04505.12 KPI90787.1 - 0.086 13.0 0.0 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 Interferon-induced transmembrane protein ANAPC3 PF12895.7 KPI90787.1 - 0.28 11.5 2.8 5.4 7.3 0.2 3.4 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 KPI90787.1 - 3.8 8.2 21.7 1.3 9.7 3.4 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KPI90787.1 - 4.3 7.6 5.5 4.3 7.6 0.6 3.6 5 0 0 5 5 4 0 Tetratricopeptide repeat DNA_pol_E_B PF04042.16 KPI90788.1 - 5e-13 48.9 0.1 1.9e-10 40.5 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase alpha/epsilon subunit B SpoU_methylase PF00588.19 KPI90789.1 - 1.2e-08 35.2 0.2 0.0075 16.4 0.1 4.0 3 1 0 3 3 3 2 SpoU rRNA Methylase family PP2C PF00481.21 KPI90791.1 - 8.5e-68 228.8 0.0 1.3e-67 228.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3270 PF11674.8 KPI90791.1 - 0.051 13.8 0.4 0.097 12.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) SpoIIE PF07228.12 KPI90791.1 - 0.11 12.4 0.0 0.6 10.0 0.0 2.0 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) DUF2198 PF09964.9 KPI90791.1 - 3.4 7.8 6.0 7.3 6.7 6.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2198) NAD_synthase PF02540.17 KPI90793.1 - 3e-31 108.4 0.0 3.8e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 KPI90793.1 - 0.014 15.1 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase DUF3720 PF12517.8 KPI90794.1 - 0.63 11.0 5.0 0.26 12.2 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3720) Imm64 PF15600.6 KPI90796.1 - 0.0061 16.2 0.0 0.0086 15.8 0.0 1.2 1 0 0 1 1 1 1 Immunity protein 64 Aminotran_4 PF01063.19 KPI90796.1 - 0.066 13.1 0.1 0.087 12.7 0.1 1.1 1 0 0 1 1 1 0 Amino-transferase class IV FUSC_2 PF13515.6 KPI90798.1 - 3e-06 27.4 8.5 3e-06 27.4 8.5 2.3 2 1 0 2 2 2 1 Fusaric acid resistance protein-like Mannosyl_trans4 PF15971.5 KPI90798.1 - 7.7 6.3 9.0 2.4 8.0 4.3 2.1 2 0 0 2 2 2 0 DolP-mannose mannosyltransferase PIN_11 PF18479.1 KPI90800.1 - 0.0026 17.9 0.3 0.68 10.1 0.3 2.4 1 1 0 1 1 1 1 PIN like domain PIF1 PF05970.14 KPI90802.1 - 1.6e-36 126.2 0.8 3e-15 56.3 0.3 4.1 4 0 0 4 4 4 4 PIF1-like helicase AAA_30 PF13604.6 KPI90802.1 - 2.1e-13 50.4 0.0 1.4e-12 47.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KPI90802.1 - 3.3e-07 30.8 0.0 1e-06 29.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 KPI90802.1 - 1.7e-05 25.2 0.0 8.2e-05 23.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KPI90802.1 - 0.00038 20.2 0.1 0.0008 19.2 0.1 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 KPI90802.1 - 0.0006 20.1 0.1 0.0059 16.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain SH3_13 PF18335.1 KPI90802.1 - 0.0014 18.5 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain CbiA PF01656.23 KPI90802.1 - 0.0017 18.4 1.5 0.0043 17.1 1.5 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 KPI90802.1 - 0.003 17.5 0.2 0.62 10.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 KPI90802.1 - 0.0098 15.7 0.3 5 6.8 0.0 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 KPI90802.1 - 0.018 14.8 0.9 0.047 13.4 0.4 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 KPI90802.1 - 0.019 14.9 1.8 0.04 13.8 0.2 2.1 2 0 0 2 2 2 0 NACHT domain Helicase_RecD PF05127.14 KPI90802.1 - 0.019 14.8 1.0 1.4 8.8 0.4 2.5 2 0 0 2 2 2 0 Helicase Herpes_Helicase PF02689.14 KPI90802.1 - 0.025 12.5 1.0 5 4.9 0.0 2.8 3 0 0 3 3 3 0 Helicase MeaB PF03308.16 KPI90802.1 - 0.071 12.1 0.4 0.12 11.3 0.4 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 KPI90802.1 - 0.072 13.0 0.1 1.2 9.0 0.1 2.2 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 KPI90802.1 - 0.36 10.4 2.7 0.52 9.9 1.6 1.8 2 0 0 2 2 2 0 AAA domain PMI_typeI PF01238.21 KPI90803.1 - 3.6e-86 289.7 0.0 4.4e-86 289.4 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I DUF3136 PF11334.8 KPI90803.1 - 0.028 14.2 0.1 0.072 12.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) ArfGap PF01412.18 KPI90804.1 - 7.7e-40 135.6 0.0 1.5e-39 134.7 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CLU PF13236.6 KPI90805.1 - 1.5e-13 51.1 0.0 2.4e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 KPI90805.1 - 3e-08 33.9 0.0 5.6e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TFIIF_alpha PF05793.12 KPI90805.1 - 0.95 8.0 1.8 1.3 7.6 1.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PSP1 PF04468.12 KPI90806.1 - 4e-22 78.3 1.6 8.4e-22 77.3 1.2 1.8 2 0 0 2 2 2 1 PSP1 C-terminal conserved region NUDIX PF00293.28 KPI90807.1 - 1.4e-08 34.8 0.0 5.2e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain DUF4815 PF16075.5 KPI90808.1 - 0.076 11.3 0.1 0.1 10.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) YqaJ PF09588.10 KPI90809.1 - 2e-43 148.1 0.0 2.9e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain Phosphonate-bd PF12974.7 KPI90810.1 - 0.0036 16.9 0.2 0.014 15.0 0.1 1.8 1 1 1 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein Peptidase_M41 PF01434.18 KPI90811.1 - 2.6e-47 161.1 0.5 4e-47 160.5 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KPI90811.1 - 1.3e-40 138.9 0.0 2.7e-40 137.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KPI90811.1 - 8.4e-05 23.0 0.1 0.001 19.5 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_lid_3 PF17862.1 KPI90811.1 - 0.0036 17.1 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KPI90811.1 - 0.004 17.4 0.2 0.037 14.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 KPI90811.1 - 0.011 15.0 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activat PF00158.26 KPI90811.1 - 0.012 15.3 0.0 0.079 12.7 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 KPI90811.1 - 0.027 14.5 0.2 0.16 12.0 0.2 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KPI90811.1 - 0.028 14.1 0.0 0.086 12.6 0.0 1.9 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Zeta_toxin PF06414.12 KPI90811.1 - 0.038 13.3 0.1 0.097 11.9 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 KPI90811.1 - 0.066 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2075 PF09848.9 KPI90811.1 - 0.09 12.0 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.14 KPI90811.1 - 0.15 12.2 0.3 1.5 8.9 0.2 2.5 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 KPI90811.1 - 0.18 11.7 0.0 0.66 9.9 0.0 1.9 2 0 0 2 2 2 0 NACHT domain DpnD-PcfM PF14207.6 KPI90811.1 - 1 9.3 3.0 2.2 8.2 0.4 2.3 2 0 0 2 2 2 0 DpnD/PcfM-like protein rRNA_processing PF08524.11 KPI90813.1 - 9.2e-10 38.7 29.8 9.8e-09 35.4 29.8 2.0 1 1 0 1 1 1 1 rRNA processing Polyoma_coat2 PF00761.20 KPI90813.1 - 1.5 8.5 4.1 0.66 9.6 1.8 1.6 1 1 1 2 2 2 0 Polyomavirus coat protein MIP-T3 PF10243.9 KPI90815.1 - 6.7e-26 90.5 0.0 1.1e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 CH-like domain F_actin_bund_C PF18060.1 KPI90815.1 - 0.15 12.2 5.9 0.27 11.4 5.9 1.4 1 0 0 1 1 1 0 F actin bundling C terminal Histone_HNS PF00816.21 KPI90815.1 - 0.68 10.8 3.4 2.2 9.2 3.4 1.9 1 0 0 1 1 1 0 H-NS histone family PI3_PI4_kinase PF00454.27 KPI90816.1 - 1.1e-45 156.5 0.1 2.1e-45 155.5 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KPI90816.1 - 2e-10 40.3 0.7 2e-10 40.3 0.7 2.2 2 0 0 2 2 2 1 FATC domain FAT PF02259.23 KPI90816.1 - 1.8e-06 27.5 0.1 0.00052 19.3 0.0 3.1 2 1 0 2 2 2 2 FAT domain CART PF06373.11 KPI90819.1 - 0.0037 17.4 0.0 0.0079 16.4 0.0 1.4 1 0 0 1 1 1 1 Cocaine and amphetamine regulated transcript protein (CART) TF_Zn_Ribbon PF08271.12 KPI90819.1 - 0.034 13.7 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding DUF4411 PF14367.6 KPI90819.1 - 0.084 12.8 1.1 0.15 12.0 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Cyclase PF04199.13 KPI90821.1 - 1.3e-07 31.9 0.0 3.5e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Putative cyclase DEAD PF00270.29 KPI90822.1 - 8.1e-20 71.3 0.0 1.9e-19 70.1 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase Sec63 PF02889.16 KPI90822.1 - 1e-16 60.9 0.0 9.1e-15 54.5 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain ResIII PF04851.15 KPI90822.1 - 3.4e-07 30.4 0.0 1.3e-06 28.5 0.0 2.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KPI90822.1 - 1.7e-06 28.3 0.0 8.5e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain T2SSE PF00437.20 KPI90822.1 - 0.0084 15.2 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein WH1 PF00568.23 KPI90822.1 - 0.2 11.6 0.1 0.49 10.4 0.1 1.6 1 0 0 1 1 1 0 WH1 domain AAA PF00004.29 KPI90826.1 - 0.0014 19.1 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KPI90826.1 - 0.017 15.7 0.0 0.035 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KPI90826.1 - 0.032 14.4 0.0 0.065 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KPI90826.1 - 0.036 14.1 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain GPHH PF16905.5 KPI90826.1 - 0.23 11.3 0.9 20 5.0 0.1 2.4 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated PAM2 PF07145.15 KPI90826.1 - 0.24 11.2 1.5 0.8 9.5 1.5 1.9 1 0 0 1 1 1 0 Ataxin-2 C-terminal region mRNA_cap_enzyme PF01331.19 KPI90827.1 - 2.2e-08 34.2 0.0 3.4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain ADK PF00406.22 KPI90827.1 - 4.1e-05 23.7 0.0 7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.6 KPI90827.1 - 5.5e-05 23.7 0.0 0.00011 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KPI90827.1 - 7.7e-05 23.1 0.0 0.00022 21.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain mRNA_cap_C PF03919.15 KPI90827.1 - 0.00015 22.3 0.0 0.00036 21.1 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain AAA_22 PF13401.6 KPI90827.1 - 0.014 15.7 0.0 0.033 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KPI90827.1 - 0.019 15.1 0.0 0.054 13.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KPI90827.1 - 0.02 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KPI90827.1 - 0.021 14.5 0.0 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase Cytidylate_kin PF02224.18 KPI90827.1 - 0.021 14.5 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA_14 PF13173.6 KPI90827.1 - 0.028 14.4 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KPI90827.1 - 0.1 11.8 0.0 0.39 10.0 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.22 KPI90827.1 - 0.17 11.5 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Hydin_ADK PF17213.3 KPI90827.1 - 0.88 9.8 4.2 15 5.8 0.0 2.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF2397 PF09660.10 KPI90827.1 - 2.2 7.1 4.9 3.9 6.3 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) LicD PF04991.13 KPI90828.1 - 2.7e-07 30.9 0.0 4.4e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 LicD family CPSF_A PF03178.15 KPI90829.1 - 6.1e-61 206.5 0.0 1e-60 205.8 0.0 1.4 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 KPI90829.1 - 3.2e-22 78.9 0.1 7.3e-17 61.2 0.0 3.5 2 1 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Peptidase_C97 PF05903.14 KPI90830.1 - 2.6e-18 66.3 0.1 4e-18 65.7 0.1 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 KPI90830.1 - 0.018 14.3 0.2 0.028 13.7 0.2 1.3 1 0 0 1 1 1 0 PUL domain WHIM1 PF15612.6 KPI90830.1 - 0.15 11.6 0.0 0.4 10.3 0.0 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 DUF4202 PF13875.6 KPI90830.1 - 0.24 11.3 0.0 0.76 9.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4202) WLM PF08325.10 KPI90831.1 - 3.8e-34 118.4 0.0 1.9e-33 116.1 0.0 2.0 1 1 0 1 1 1 1 WLM domain DUF45 PF01863.17 KPI90831.1 - 0.17 11.9 1.3 0.27 11.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF45 OrfB_Zn_ribbon PF07282.11 KPI90831.1 - 0.2 11.6 1.5 0.49 10.4 1.5 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-RanBP PF00641.18 KPI90831.1 - 0.92 8.9 7.3 1.9 7.9 7.3 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF3439 PF11921.8 KPI90831.1 - 2.8 7.9 8.5 6.2 6.8 8.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pep_deformylase PF01327.21 KPI90832.1 - 7.2e-29 100.4 0.0 9.7e-29 100.0 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase ArAE_2 PF10334.9 KPI90832.1 - 0.05 13.4 0.6 0.12 12.2 0.0 1.8 3 0 0 3 3 3 0 Aromatic acid exporter family member 2 Pkinase PF00069.25 KPI90833.1 - 3.9e-08 33.0 0.0 6.3e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90833.1 - 1e-07 31.5 0.0 1.5e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KPI90833.1 - 0.0015 18.5 0.0 0.0034 17.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KPI90833.1 - 0.0029 17.2 0.0 0.037 13.6 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 KPI90833.1 - 0.024 13.6 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain UPF0731 PF14982.6 KPI90834.1 - 0.02 15.1 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 UPF0731 family SHS2_Rpb7-N PF03876.17 KPI90835.1 - 1.6e-13 50.8 0.0 2.7e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CRAL_TRIO PF00650.20 KPI90836.1 - 1.2e-29 103.0 0.0 2.3e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KPI90836.1 - 1.6e-05 25.1 0.1 3.4e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KPI90837.1 - 1.1e-32 112.9 0.0 1.7e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KPI90837.1 - 2.2e-05 24.6 0.0 5.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KPI90837.1 - 0.00044 20.4 0.2 0.00097 19.3 0.2 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO PF00650.20 KPI90838.1 - 1.8e-36 125.3 0.0 3.3e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KPI90838.1 - 0.00035 20.7 0.0 0.00069 19.7 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KPI90838.1 - 0.014 15.6 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KPI90839.1 - 1.1e-32 112.9 0.0 1.6e-32 112.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 KPI90839.1 - 0.0013 19.2 0.1 0.5 10.9 0.0 2.2 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.6 KPI90839.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain UCH PF00443.29 KPI90840.1 - 3.8e-30 105.3 0.0 5.6e-29 101.4 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KPI90840.1 - 1.6e-11 44.4 0.7 3.5e-06 26.8 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF4176 PF13780.6 KPI90840.1 - 0.045 13.8 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) SFTA2 PF15210.6 KPI90840.1 - 0.048 13.6 0.6 1.3 9.1 0.0 2.8 3 0 0 3 3 3 0 Surfactant-associated protein 2 Ipi1_N PF12333.8 KPI90840.1 - 0.76 10.4 0.0 0.76 10.4 0.0 2.5 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation PHTB1_C PF14728.6 KPI90841.1 - 4.4e-93 312.4 0.2 6.5e-93 311.8 0.2 1.2 1 0 0 1 1 1 1 PTHB1 C-terminus PHTB1_N PF14727.6 KPI90841.1 - 9.6e-92 308.5 0.0 1.1e-68 232.6 0.0 2.2 2 0 0 2 2 2 2 PTHB1 N-terminus ArfGap PF01412.18 KPI90842.1 - 1.3e-27 96.2 0.1 2.5e-27 95.3 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.12 KPI90842.1 - 0.018 14.6 2.2 0.032 13.8 2.2 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding NBP1 PF08537.10 KPI90843.1 - 0.0075 15.7 3.9 0.084 12.3 0.1 2.6 2 0 0 2 2 2 1 Fungal Nap binding protein NBP1 KI67R PF08065.12 KPI90843.1 - 0.032 14.8 0.4 0.032 14.8 0.4 2.4 2 0 0 2 2 2 0 KI67R (NUC007) repeat DUF4407 PF14362.6 KPI90843.1 - 0.41 10.0 9.4 1.2 8.4 1.4 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4140 PF13600.6 KPI90843.1 - 0.43 11.0 6.5 1.7 9.1 0.1 4.0 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) CC2-LZ PF16516.5 KPI90843.1 - 0.53 10.7 8.6 1.2 9.6 1.9 3.3 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Pox_A_type_inc PF04508.12 KPI90843.1 - 0.84 9.6 6.0 0.66 9.9 3.4 2.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Sipho_Gp157 PF05565.11 KPI90843.1 - 1.5 8.9 6.4 0.49 10.4 2.1 2.4 2 0 0 2 2 2 0 Siphovirus Gp157 Flagellin_N PF00669.20 KPI90843.1 - 3.5 7.7 8.5 11 6.1 0.1 3.8 4 0 0 4 4 4 0 Bacterial flagellin N-terminal helical region Sec8_exocyst PF04048.14 KPI90843.1 - 6 6.7 7.9 1.7 8.5 0.9 3.4 3 1 0 3 3 3 0 Sec8 exocyst complex component specific domain CtIP_N PF10482.9 KPI90843.1 - 8.3 6.5 16.2 0.06 13.4 3.6 3.4 3 2 0 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain PPR_2 PF13041.6 KPI90844.1 - 1.6e-38 130.6 32.1 7.9e-13 48.4 0.1 13.2 8 3 5 14 14 14 9 PPR repeat family PPR_3 PF13812.6 KPI90844.1 - 2.3e-36 123.7 7.4 9.9e-13 48.0 0.0 8.9 5 2 7 12 12 12 9 Pentatricopeptide repeat domain PPR_long PF17177.4 KPI90844.1 - 1e-15 57.7 12.4 3.4e-09 36.4 0.2 6.0 3 2 1 6 6 6 4 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KPI90844.1 - 2.9e-13 49.1 25.8 6.5e-06 26.1 0.0 10.6 13 0 0 13 13 13 4 PPR repeat PPR_1 PF12854.7 KPI90844.1 - 5.1e-13 48.5 20.3 5.4e-08 32.4 0.0 8.1 10 0 0 10 10 10 3 PPR repeat RPM2 PF08579.11 KPI90844.1 - 4.7e-05 23.8 2.5 3.1 8.2 0.0 5.4 4 1 1 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) COX5A PF02284.16 KPI90844.1 - 0.00028 20.8 1.4 4.2 7.4 0.0 4.4 3 1 1 4 4 4 1 Cytochrome c oxidase subunit Va Ssu72 PF04722.13 KPI90844.1 - 0.0013 18.3 0.1 0.13 11.8 0.0 2.5 2 1 0 2 2 2 1 Ssu72-like protein FERM_M PF00373.18 KPI90844.1 - 0.058 13.8 1.3 6.8 7.1 0.0 2.9 3 0 0 3 3 2 0 FERM central domain ECSIT PF06239.11 KPI90844.1 - 0.08 12.1 1.8 5.4 6.1 0.2 4.2 3 2 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway SPOR PF05036.13 KPI90844.1 - 0.16 12.4 0.3 91 3.5 0.0 4.1 4 1 0 5 5 5 0 Sporulation related domain CSN8_PSD8_EIF3K PF10075.9 KPI90845.1 - 5.1e-26 91.4 0.0 8.4e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 KPI90845.1 - 0.018 14.4 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 SAC3/GANP family Ank_4 PF13637.6 KPI90847.1 - 5.1e-11 42.9 3.0 2.8e-07 30.9 0.1 3.2 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KPI90847.1 - 1.7e-06 27.9 0.2 0.00085 19.6 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KPI90847.1 - 8.6e-06 26.0 0.7 0.075 13.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 KPI90847.1 - 1.6e-05 25.4 0.1 3.9e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KPI90847.1 - 1.7e-05 25.0 0.2 4.9e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF1489 PF07370.11 KPI90848.1 - 0.057 13.1 0.0 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1489) ELO PF01151.18 KPI90849.1 - 3.3e-47 161.1 19.4 4.2e-47 160.8 19.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Mito_carr PF00153.27 KPI90853.1 - 2.2e-52 175.0 4.8 2.9e-17 62.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 KPI90854.1 - 2.6e-45 152.3 4.4 3.7e-17 62.0 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein 60KD_IMP PF02096.20 KPI90854.1 - 0.0004 20.3 0.1 0.0094 15.9 0.1 2.2 1 1 0 1 1 1 1 60Kd inner membrane protein DUF4199 PF13858.6 KPI90854.1 - 0.049 14.0 1.1 0.081 13.3 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Dapper PF15268.6 KPI90854.1 - 7.6 5.2 5.6 12 4.7 5.6 1.2 1 0 0 1 1 1 0 Dapper CRM1_C PF08767.11 KPI90855.1 - 1e-62 212.2 0.2 1e-62 212.2 0.2 3.0 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 KPI90855.1 - 4.6e-27 94.9 3.1 1.4e-26 93.4 0.3 3.3 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 KPI90855.1 - 1.1e-24 85.8 1.5 3.3e-24 84.3 1.5 1.9 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 KPI90855.1 - 9e-23 80.1 2.1 9e-23 80.1 2.1 2.3 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 IBN_N PF03810.19 KPI90855.1 - 6.5e-12 45.2 4.1 7.1e-12 45.1 0.5 3.0 4 0 0 4 4 4 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 KPI90855.1 - 3.8e-08 32.7 2.9 1.2e-07 31.1 2.9 1.9 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat DASH_Dad2 PF08654.10 KPI90855.1 - 0.078 13.4 0.1 0.31 11.5 0.1 2.0 1 0 0 1 1 1 0 DASH complex subunit Dad2 MMS19_N PF14500.6 KPI90855.1 - 0.88 9.1 5.1 1.4 8.4 0.0 3.2 4 1 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II HECT PF00632.25 KPI90856.1 - 1.3e-67 228.5 0.0 1.9e-67 228.0 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Nsp2a_N PF17896.1 KPI90856.1 - 0.00043 19.6 0.1 0.0056 15.9 0.0 2.1 2 0 0 2 2 2 1 Replicase polyprotein 1a N-terminal domain HEAT_2 PF13646.6 KPI90856.1 - 0.0011 19.3 0.6 3.9 7.9 0.3 3.2 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.22 KPI90856.1 - 0.0027 17.8 2.9 5.5 7.5 0.0 4.6 4 0 0 4 4 4 2 HEAT repeat ZZ PF00569.17 KPI90856.1 - 0.046 13.5 8.1 0.019 14.8 4.7 2.0 2 0 0 2 2 2 0 Zinc finger, ZZ type C1_2 PF03107.16 KPI90856.1 - 0.19 12.0 4.4 0.46 10.8 4.4 1.6 1 0 0 1 1 1 0 C1 domain LSM PF01423.22 KPI90858.1 - 1.9e-15 56.3 0.1 2.1e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KPI90858.1 - 0.00013 22.0 0.0 0.00015 21.9 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain WD40 PF00400.32 KPI90859.1 - 2.2e-06 28.3 11.0 0.15 13.0 0.1 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KPI90859.1 - 4.5e-05 23.7 0.1 0.068 13.5 0.0 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Metallophos_2 PF12850.7 KPI90860.1 - 3.2e-12 47.0 0.0 3.9e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain UPF0242 PF06785.11 KPI90861.1 - 0.00076 19.6 8.7 0.00076 19.6 8.7 2.9 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Sin3_corepress PF08295.12 KPI90861.1 - 0.048 13.7 2.3 0.091 12.8 1.3 2.0 1 1 0 1 1 1 0 Sin3 family co-repressor DUF763 PF05559.11 KPI90861.1 - 0.18 11.0 5.6 0.62 9.2 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF763) CdvA PF18822.1 KPI90861.1 - 0.9 9.4 21.1 6.9 6.5 2.5 4.3 3 1 1 4 4 4 0 CdvA-like coiled-coil domain DUF3584 PF12128.8 KPI90861.1 - 2 5.8 38.0 0.14 9.7 14.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) FPP PF05911.11 KPI90861.1 - 9.9 4.2 35.1 0.019 13.2 11.7 2.7 1 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil Maf PF02545.14 KPI90862.1 - 1.7e-16 60.5 0.0 2e-16 60.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein DUF3801 PF12687.7 KPI90862.1 - 0.19 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Pkinase PF00069.25 KPI90863.1 - 4.2e-32 111.5 0.4 3e-25 89.1 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KPI90863.1 - 9.6e-18 64.4 0.2 1.9e-17 63.4 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KPI90863.1 - 0.00079 19.1 0.0 0.0042 16.8 0.0 2.1 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KPI90863.1 - 0.027 14.4 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KPI90863.1 - 0.056 12.2 0.1 0.099 11.4 0.1 1.4 1 1 0 1 1 1 0 Fungal protein kinase Y_phosphatase2 PF03162.13 KPI90864.1 - 2.2e-23 82.6 0.0 2e-22 79.5 0.0 2.2 1 1 0 1 1 1 1 Tyrosine phosphatase family GPCR_chapero_1 PF11904.8 KPI90864.1 - 0.058 12.8 0.1 0.084 12.3 0.1 1.2 1 0 0 1 1 1 0 GPCR-chaperone Cpn60_TCP1 PF00118.24 KPI90865.1 - 1.6e-150 502.0 1.6 1.8e-150 501.8 1.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 KPI90866.1 - 2.3e-05 25.1 2.2 0.0012 19.6 0.1 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat GREB1 PF15782.5 KPI90866.1 - 9 3.3 9.6 13 2.7 9.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Vps23_core PF09454.10 KPI90867.1 - 2.9e-16 59.1 0.0 7.7e-16 57.8 0.0 1.8 1 0 0 1 1 1 1 Vps23 core domain Vps5 PF09325.10 KPI90867.1 - 0.012 15.2 0.6 0.017 14.7 0.6 1.2 1 0 0 1 1 1 0 Vps5 C terminal like CheZ PF04344.13 KPI90867.1 - 0.026 14.5 0.6 0.043 13.7 0.6 1.4 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ CUE PF02845.16 KPI90867.1 - 0.033 13.9 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 CUE domain Exonuc_VII_L PF02601.15 KPI90867.1 - 0.033 13.8 0.8 0.049 13.2 0.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PCRF PF03462.18 KPI90867.1 - 0.091 12.6 2.4 0.13 12.1 2.4 1.2 1 0 0 1 1 1 0 PCRF domain DUF2203 PF09969.9 KPI90867.1 - 0.2 12.4 0.9 0.44 11.3 0.9 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) UPF0449 PF15136.6 KPI90867.1 - 0.28 11.7 1.9 0.73 10.3 1.9 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 KxDL PF10241.9 KPI90867.1 - 0.3 11.4 3.4 0.16 12.2 0.9 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein RRM_1 PF00076.22 KPI90868.1 - 0.00028 20.7 0.0 0.00057 19.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TackOD1 PF18551.1 KPI90868.1 - 0.018 14.7 3.4 0.038 13.7 3.4 1.5 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Peptidase_C2 PF00648.21 KPI90869.1 - 2.2e-07 30.2 0.0 9.8e-07 28.1 0.0 1.9 2 0 0 2 2 2 1 Calpain family cysteine protease UQ_con PF00179.26 KPI90870.1 - 1.9e-42 144.3 0.0 2.4e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SNase PF00565.17 KPI90871.1 - 2.5e-50 169.5 2.9 7.4e-15 55.4 0.0 5.3 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 KPI90871.1 - 2e-16 60.1 0.0 5.5e-16 58.7 0.0 1.7 2 0 0 2 2 2 1 Tudor domain DUF4537 PF15057.6 KPI90871.1 - 0.018 15.1 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) CLASP_N PF12348.8 KPI90872.1 - 3.5e-16 59.5 2.0 5.6e-16 58.8 0.4 2.0 2 0 0 2 2 2 1 CLASP N terminal DAO PF01266.24 KPI90873.1 - 1.2e-05 25.1 0.3 0.0035 17.0 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase GMC_oxred_N PF00732.19 KPI90873.1 - 3.9e-05 23.2 1.0 0.0087 15.5 0.1 2.9 3 0 0 3 3 3 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 KPI90873.1 - 0.0041 16.4 0.0 0.0098 15.2 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KPI90873.1 - 0.0065 15.6 0.3 0.18 10.9 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 KPI90873.1 - 0.0085 15.2 0.0 0.02 13.9 0.0 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KPI90873.1 - 0.011 16.0 1.0 0.025 14.8 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KPI90873.1 - 0.028 14.4 0.1 0.067 13.2 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 KPI90873.1 - 0.043 13.1 0.0 0.093 12.0 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KPI90873.1 - 0.056 12.1 0.0 0.094 11.4 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 KPI90873.1 - 0.13 11.5 0.1 0.3 10.3 0.0 1.5 2 0 0 2 2 2 0 Thi4 family V_ATPase_I PF01496.19 KPI90875.1 - 3.7e-247 822.3 0.0 5.6e-247 821.7 0.0 1.3 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family Dynamitin PF04912.14 KPI90875.1 - 0.013 14.9 1.0 0.013 14.9 1.0 1.5 2 0 0 2 2 2 0 Dynamitin Abhydrolase_6 PF12697.7 KPI90876.1 - 1.4e-14 55.2 0.3 6.3e-14 53.1 0.3 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KPI90876.1 - 1.1e-08 34.6 0.6 2.6e-07 30.1 0.1 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KPI90876.1 - 0.0011 18.7 0.1 0.075 12.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 KPI90876.1 - 0.006 15.5 0.0 1.1 8.1 0.0 2.4 2 0 0 2 2 2 2 Chlorophyllase enzyme Mannitol_dh_C PF08125.13 KPI90878.1 - 3e-55 187.4 0.0 4.1e-55 186.9 0.0 1.1 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 KPI90878.1 - 5.3e-33 114.3 0.0 8.1e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain CTP_transf_like PF01467.26 KPI90879.1 - 3e-46 157.2 0.0 4.7e-24 85.2 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 KPI90879.1 - 2.1e-06 27.7 2.7 0.099 12.5 0.2 3.7 2 2 0 2 2 2 2 FAD synthetase CHAP PF05257.16 KPI90879.1 - 0.13 12.9 0.0 1.5 9.4 0.0 2.3 2 0 0 2 2 2 0 CHAP domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Leptomonas_seymouri_ATCC_30220-ASM129953v1/GCA_001299535.1_ASM129953v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Leptomonas_seymouri_ATCC_30220-ASM129953v1/GCA_001299535.1_ASM129953v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Leptomonas_seymouri_ATCC_30220-ASM129953v1/GCA_001299535.1_ASM129953v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Leptomonas_seymouri_ATCC_30220-ASM129953v1/GCA_001299535.1_ASM129953v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 08:51:44 2019 # [ok]